		Clinical Features	CN_CNMF		METHLYATION_CNMF		RPPA_CNMF		RPPA_CHIERARCHICAL		MRNASEQ_CNMF		MRNASEQ_CHIERARCHICAL		MIRSEQ_CNMF		MIRSEQ_CHIERARCHICAL		MIRSEQ_MATURE_CNMF		MIRSEQ_MATURE_CHIERARCHICAL	
	nMutated (%)	nWild-Type	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q
ZFPM1	24 (39%)	38	0.80381	1	0.81514	1	0.71768	1	0.87102	1	0.37295	1	0.74647	1	0.8242	1	0.92224	1	0.38344	1	0.74273	1
LACTB	19 (31%)	43	0.43775	1	0.6886	1	0.68599	1	0.56724	1	1	1	0.3179	1	0.37681	1	0.75138	1	0.32192	1	0.17937	1
CCDC102A	17 (27%)	45	0.01856	1	0.93383	1	0.67029	1	0.50639	1	0.97478	1	0.82333	1	0.49802	1	0.46861	1	0.80597	1	0.51089	1
ZNF517	13 (21%)	49	0.1667	1	0.98056	1	1	1	NA	NA	0.82071	1	0.95127	1	0.17324	1	0.69637	1	0.72417	1	0.77494	1
MAL2	11 (18%)	51	0.49862	1	0.31185	1	1	1	1	1	0.25504	1	0.50605	1	0.22258	1	0.26807	1	1	1	0.86938	1
TOR3A	12 (19%)	50	0.61185	1	0.01352	1	0.15278	1	0.31329	1	0.67401	1	0.0053999	1	1	1	0.84258	1	0.91131	1	0.80754	1
TP53	13 (21%)	49	0.11434	1	0.81756	1	0.22126	1	0.60282	1	0.02077	1	0.32087	1	0.0052299	1	0.59779	1	0.04934	1	0.18472	1
CLDN23	10 (16%)	52	0.56671	1	0.25	1	1	1	0.34954	1	0.02952	1	0.21102	1	0.097499	1	0.18209	1	0.41683	1	0.5435	1
GDF1	5 (8%)	57	0.85854	1	0.28633	1	1	1	NA	NA	0.43645	1	0.35354	1	0.055329	1	0.51141	1	0.1722	1	0.17346	1
LZTR1	6 (10%)	56	0.052529	1	0.85229	1	1	1	NA	NA	0.088329	1	0.11713	1	0.40118	1	0.01539	1	1	1	0.45476	1
ANKRD43	19 (31%)	43	0.1613	1	0.56448	1	0.68599	1	0.60275	1	0.28003	1	0.22782	1	0.36663	1	0.10183	1	0.60564	1	0.4629	1
KCNK17	9 (15%)	53	0.20364	1	0.04031	1	0.01784	1	0.44172	1	0.10388	1	0.0089199	1	0.88936	1	0.54606	1	0.71842	1	0.44458	1
RINL	8 (13%)	54	0.34136	1	0.67635	1	1	1	0.57941	1	0.4689	1	0.27711	1	0.76128	1	0.17031	1	0.34776	1	0.74937	1
ZAR1	11 (18%)	51	0.64474	1	0.6698	1	1	1	0.79216	1	0.62182	1	0.86924	1	0.71414	1	0.97092	1	1	1	0.60203	1
CTNNB1	8 (13%)	54	0.39632	1	0.060869	1	0.63889	1	0.31372	1	0.0054499	1	0.0062499	1	7.9999e-05	0.0928	0.16993	1	0.04576	1	0.54748	1
APOE	7 (11%)	55	1	1	0.59467	1	1	1	0.38191	1	0.059159	1	0.39881	1	0.19304	1	0.7906	1	0.42018	1	1	1
GPRIN2	8 (13%)	54	0.86707	1	0.38308	1	1	1	0.69381	1	0.68142	1	0.4003	1	0.58117	1	0.75457	1	0.59395	1	0.18039	1
ASPDH	8 (13%)	54	0.29532	1	0.69096	1	1	1	0.31488	1	0.02341	1	0.39558	1	0.47551	1	0.03231	1	0.21137	1	0.081229	1
ERCC2	10 (16%)	52	1	1	0.23279	1	0.037681	1	0.23146	1	0.48225	1	0.17421	1	0.59935	1	0.27032	1	0.33576	1	0.20663	1
IDUA	8 (13%)	54	0.38427	1	0.85243	1	1	1	0.79248	1	0.50857	1	0.54893	1	0.1995	1	0.4296	1	0.45845	1	0.64699	1
C1ORF106	9 (15%)	53	0.84103	1	0.46956	1	0.63889	1	0.04693	1	0.34041	1	0.75939	1	0.47394	1	0.6892	1	0.052989	1	1	1
C10ORF95	6 (10%)	56	0.19863	1	0.37888	1	1	1	NA	NA	0.51367	1	1	1	0.48818	1	0.35917	1	1	1	1	1
RGS9BP	8 (13%)	54	0.72406	1	0.62879	1	1	1	0.12871	1	1	1	0.93361	1	0.21837	1	0.96245	1	0.34213	1	0.74982	1
THEM4	5 (8%)	57	0.27894	1	0.76647	1	1	1	NA	NA	0.43785	1	0.87673	1	0.17895	1	0.10879	1	0.231	1	0.26177	1
TSC22D2	8 (13%)	54	0.94596	1	0.54065	1	1	1	0.95412	1	0.77929	1	0.81671	1	0.76016	1	0.43179	1	0.34676	1	1	1
SYT8	8 (13%)	54	0.44094	1	0.43995	1	1	1	1	1	0.04174	1	0.17565	1	1	1	0.18438	1	0.74893	1	0.49708	1
PLIN5	5 (8%)	57	0.50237	1	0.69546	1	1	1	0.38292	1	0.80037	1	0.66807	1	0.26634	1	0.26827	1	0.51096	1	0.04764	1
LRIG1	16 (26%)	46	0.54228	1	0.95907	1	1	1	1	1	0.86425	1	0.61003	1	0.36396	1	0.43044	1	0.57654	1	0.90342	1
HHIPL1	6 (10%)	56	0.27665	1	0.43589	1	0.48413	1	NA	NA	0.63213	1	0.51265	1	0.20435	1	0.42478	1	0.20184	1	0.33358	1
CCDC105	6 (10%)	56	1	1	0.0114	1	0.22619	1	0.67644	1	0.93926	1	0.79407	1	1	1	0.053839	1	0.21573	1	0.20751	1
C19ORF10	7 (11%)	55	0.7825	1	0.42332	1	0.6	1	0.39441	1	0.24037	1	0.12371	1	0.55149	1	0.8628	1	0.63939	1	0.71448	1
OPRD1	12 (19%)	50	0.96668	1	0.43542	1	0.65459	1	0.47957	1	0.7982	1	0.95988	1	0.2977	1	0.61132	1	1	1	0.51295	1
ATXN1	10 (16%)	52	0.556	1	0.13911	1	0.6	1	0.91568	1	0.24049	1	0.65391	1	0.28609	1	0.8711	1	0.23611	1	0.31614	1
AATK	6 (10%)	56	0.13889	1	0.33308	1	1	1	NA	NA	0.43781	1	0.35569	1	1	1	0.54472	1	1	1	0.6201	1
ZNF628	7 (11%)	55	0.2087	1	0.92578	1	1	1	0.6724	1	0.30699	1	0.11382	1	0.091289	1	0.50187	1	0.28325	1	0.54447	1
KRTAP4-5	5 (8%)	57	0.63211	1	0.28539	1	0.48413	1	NA	NA	0.90897	1	0.87516	1	1	1	0.84003	1	0.4344	1	1	1
NOXA1	5 (8%)	57	0.14233	1	0.51514	1	1	1	NA	NA	0.22267	1	0.44454	1	0.29404	1	0.34935	1	0.25516	1	0.71915	1
TRIOBP	10 (16%)	52	0.62219	1	0.22872	1	0.58333	1	0.12846	1	1	1	0.11118	1	0.71335	1	0.87182	1	1	1	0.77405	1
ZNF598	12 (19%)	50	0.10837	1	0.31492	1	1	1	0.74756	1	0.49001	1	0.95179	1	1	1	0.22444	1	0.9015	1	1	1
IRX3	5 (8%)	57	0.14405	1	0.70396	1	0.48413	1	NA	NA	0.52393	1	0.12038	1	0.17567	1	0.77822	1	0.23041	1	0.45171	1
WDR34	5 (8%)	57	0.62928	1	0.8293	1	0.48413	1	NA	NA	0.86511	1	0.81314	1	0.84333	1	0.5467	1	0.84391	1	0.3321	1
BHLHE22	5 (8%)	57	0.42625	1	0.073499	1	1	1	0.91571	1	0.1183	1	0.81408	1	0.58317	1	0.83652	1	0.72615	1	0.83474	1
PANK2	5 (8%)	57	0.63079	1	0.4344	1	0.22619	1	0.35258	1	0.11407	1	0.050429	1	0.42714	1	0.34894	1	1	1	0.25493	1
FPGS	5 (8%)	57	1	1	1	1	1	1	0.35075	1	0.66681	1	0.60103	1	0.055589	1	0.62297	1	0.82316	1	0.61688	1
GLTPD2	6 (10%)	56	0.87918	1	0.84144	1	0.48413	1	NA	NA	0.82887	1	0.39678	1	0.54932	1	0.52855	1	0.87274	1	0.1319	1
TNIP2	5 (8%)	57	0.63076	1	0.70538	1	1	1	NA	NA	0.73847	1	0.87682	1	1	1	0.41376	1	1	1	0.45313	1
AKAP2	6 (10%)	56	0.11424	1	0.84115	1	1	1	0.75284	1	0.83001	1	0.59351	1	0.74717	1	0.28186	1	0.74926	1	0.40984	1
RREB1	5 (8%)	57	0.72844	1	0.85007	1	0.20635	1	NA	NA	0.61917	1	1	1	0.52615	1	0.54794	1	0.17174	1	0.35242	1
TPO	12 (19%)	50	0.26195	1	0.29967	1	0.10159	1	0.69331	1	0.17561	1	0.12485	1	0.098029	1	0.34267	1	1	1	0.1699	1
OBSCN	18 (29%)	44	0.3107	1	0.51891	1	1	1	0.54429	1	0.67219	1	0.80651	1	0.15011	1	0.49779	1	1	1	0.38491	1
SNED1	5 (8%)	57	0.62807	1	0.31106	1	0.46429	1	NA	NA	0.39733	1	0.66667	1	0.093569	1	0.66327	1	1	1	0.5426	1
MEN1	5 (8%)	57	0.41682	1	0.0491	1	0.48413	1	NA	NA	0.01293	1	0.0062099	1	0.20579	1	0.04276	1	0.13961	1	0.204	1
BTBD11	6 (10%)	56	1	1	0.31264	1	1	1	NA	NA	0.48523	1	1	1	0.48642	1	0.18469	1	0.72639	1	0.33269	1
RNF149	4 (6%)	58	0.33854	1	0.03677	1	0.58333	1	0.95476	1	0.43939	1	0.59989	1	0.31663	1	0.26083	1	0.66441	1	0.17336	1
KIAA1984	4 (6%)	58	0.41853	1	0.70911	1	0.22619	1	0.50594	1	0.12669	1	0.04939	1	0.0318	1	0.5845	1	0.6654	1	0.79606	1
CCDC150	4 (6%)	58	0.17722	1	0.84981	1	0.22619	1	0.60116	1	0.24069	1	0.11868	1	0.40015	1	0.21432	1	1	1	0.45262	1
FAM18B2	4 (6%)	58	0.74905	1	0.33349	1	1	1	NA	NA	0.16605	1	0.48344	1	0.31416	1	0.50952	1	0.82376	1	0.1724	1
MUC5B	22 (35%)	40	1	1	0.62737	1	1	1	0.81151	1	0.73424	1	0.67253	1	0.7151	1	0.61547	1	1	1	0.52949	1
PTPLA	4 (6%)	58	0.42075	1	0.32343	1	1	1	NA	NA	0.33775	1	0.44264	1	0.77657	1	1	1	0.77434	1	1	1
SRPX	3 (5%)	59	0.75417	1	0.11345	1	1	1	NA	NA	0.61689	1	1	1	0.77737	1	0.71738	1	1	1	0.40205	1
GARS	19 (31%)	43	0.072989	1	0.090999	1	0.22754	1	0.33424	1	0.33822	1	0.1024	1	0.12069	1	0.40252	1	0.2133	1	0.39428	1
PRSS27	3 (5%)	59	1	1	0.91023	1	1	1	NA	NA	0.62037	1	0.052289	1	0.12864	1	1	1	0.6143	1	0.55741	1
SEMA5B	8 (13%)	54	0.33687	1	0.26934	1	0.31111	1	0.17272	1	0.39789	1	0.21217	1	0.64868	1	0.30267	1	0.36169	1	0.41229	1
CD320	4 (6%)	58	1	1	0.85088	1	1	1	NA	NA	0.73838	1	0.6577	1	0.3994	1	0.22792	1	0.22988	1	0.25977	1
TAF5	4 (6%)	58	1	1	0.7695	1	0.58333	1	0.95487	1	1	1	0.87615	1	0.0094899	1	0.11735	1	0.055719	1	0.01458	1
NEFH	6 (10%)	56	0.051649	1	0.17232	1	0.48413	1	NA	NA	0.11344	1	0.051859	1	0.39926	1	0.21207	1	0.6676	1	0.45267	1
DMKN	3 (5%)	59	1	1	0.32838	1	0.46429	1	NA	NA	0.61838	1	0.44356	1	0.0060099	1	0.56652	1	0.25446	1	1	1
NPTX1	3 (5%)	59	0.64091	1	1	1	0.46429	1	NA	NA	1	1	0.81336	1	0.58281	1	0.79367	1	0.35057	1	0.55478	1
NOTCH2	5 (8%)	57	0.2792	1	0.89565	1	1	1	NA	NA	0.52226	1	0.11475	1	0.03068	1	0.319	1	0.66652	1	0.79521	1
RNF39	5 (8%)	57	0.72587	1	0.37844	1	0.6	1	0.79381	1	0.17535	1	0.26513	1	0.15873	1	0.69967	1	0.23889	1	0.68459	1
KBTBD13	9 (15%)	53	0.45772	1	0.11382	1	0.31111	1	0.79133	1	0.68465	1	0.11779	1	1	1	0.32843	1	1	1	0.60294	1
IER5	3 (5%)	59	0.19919	1	NA	NA	0.46429	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
SCRT1	3 (5%)	59	1	1	0.42912	1	0.46429	1	NA	NA	0.47546	1	0.61709	1	0.43239	1	0.79451	1	0.46656	1	1	1
KNDC1	9 (15%)	53	0.35313	1	0.065239	1	1	1	0.55222	1	0.02711	1	0.32449	1	0.42031	1	0.36634	1	0.19081	1	0.38152	1
MAP1S	5 (8%)	57	0.15515	1	0.27558	1	1	1	0.41774	1	0.39713	1	1	1	1	1	0.83413	1	0.42091	1	0.83574	1
RGMB	6 (10%)	56	0.65211	1	NA	NA	1	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
LRP11	6 (10%)	56	1	1	0.081979	1	1	1	NA	NA	0.79759	1	0.66485	1	0.58072	1	0.93575	1	0.83968	1	0.83689	1
AR	4 (6%)	58	0.41851	1	0.51642	1	1	1	0.95466	1	0.47642	1	0.44302	1	0.42909	1	1	1	0.2531	1	1	1
VARS	6 (10%)	56	1	1	0.42421	1	0.22619	1	0.38297	1	0.21818	1	0.066529	1	0.64628	1	0.86398	1	0.75069	1	1	1
SEZ6L2	8 (13%)	54	0.37954	1	0.66544	1	1	1	0.78824	1	0.82684	1	1	1	0.46035	1	0.63065	1	1	1	0.84872	1
PABPC1	4 (6%)	58	0.41962	1	NA	NA	0.46429	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
FANK1	3 (5%)	59	1	1	0.32537	1	1	1	NA	NA	0.8568	1	0.28538	1	0.77693	1	0.23473	1	0.77495	1	0.25778	1
NMU	5 (8%)	57	0.9136	1	1	1	0.46429	1	NA	NA	0.070259	1	0.61397	1	1	1	0.54458	1	0.82564	1	0.621	1
ADAD2	4 (6%)	58	0.41807	1	0.57351	1	1	1	NA	NA	0.74016	1	0.17133	1	0.0093099	1	0.51142	1	0.057209	1	0.35293	1
CLIC6	5 (8%)	57	0.63174	1	1	1	0.20635	1	NA	NA	0.66575	1	0.11783	1	0.17719	1	0.58393	1	0.29269	1	1	1
PCDHB13	5 (8%)	57	0.3941	1	0.14073	1	0.48413	1	NA	NA	0.12747	1	0.35538	1	0.66573	1	0.060759	1	0.43826	1	0.45349	1
PLEC	13 (21%)	49	0.4262	1	0.67297	1	0.33333	1	0.04608	1	0.20654	1	0.71697	1	0.5979	1	0.63372	1	0.14188	1	0.62518	1
AMDHD1	10 (16%)	52	0.65785	1	0.75964	1	0.22619	1	0.35159	1	0.5895	1	0.13697	1	0.17572	1	0.85145	1	0.90169	1	0.68306	1
DSPP	9 (15%)	53	0.60928	1	0.060649	1	1	1	0.69238	1	1	1	0.48207	1	0.44401	1	0.53841	1	0.89969	1	1	1
TMEM189	3 (5%)	59	0.19462	1	NA	NA	0.46429	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
CRIPAK	10 (16%)	52	0.38538	1	0.92732	1	0.6	1	0.93373	1	0.48677	1	0.68882	1	0.89369	1	0.32894	1	0.47689	1	0.36506	1
PDCD6	3 (5%)	59	0.2993	1	0.649	1	0.46429	1	NA	NA	NA	NA	NA	NA	1	1	0.63979	1	1	1	1	1
MAP7	3 (5%)	59	1	1	0.64993	1	0.46429	1	NA	NA	1	1	0.81394	1	0.5819	1	0.79245	1	1	1	0.55745	1
NOM1	6 (10%)	56	1	1	0.31275	1	1	1	NA	NA	0.86386	1	1	1	1	1	0.78839	1	0.42009	1	1	1
SHOX2	3 (5%)	59	0.408	1	NA	NA	0.46429	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
HSD17B1	4 (6%)	58	0.91433	1	0.04992	1	0.58333	1	0.50629	1	0.90857	1	0.0080099	1	1	1	0.84232	1	0.54743	1	0.79564	1
PRKAR1A	6 (10%)	56	0.61523	1	1	1	0.6	1	0.79289	1	0.27711	1	0.40195	1	0.10311	1	0.5908	1	0.04766	1	0.58681	1
KRTAP5-5	3 (5%)	59	1	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
DLEU7	3 (5%)	59	0.52836	1	NA	NA	1	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
FEZ2	3 (5%)	59	0.46303	1	0.35466	1	1	1	NA	NA	0.21927	1	0.81486	1	0.1926	1	0.79358	1	0.77441	1	0.55739	1
RASIP1	6 (10%)	56	0.36004	1	0.34874	1	1	1	NA	NA	0.04116	1	0.18757	1	0.055059	1	0.70013	1	0.41821	1	0.71314	1
JMJD4	3 (5%)	59	1	1	NA	NA	0.48413	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
COQ2	5 (8%)	57	0.35998	1	0.76619	1	1	1	NA	NA	0.43801	1	0.60127	1	1	1	0.67143	1	0.54897	1	0.61914	1
UQCRFS1	5 (8%)	57	0.75311	1	0.58723	1	0.48413	1	NA	NA	1	1	0.87677	1	0.4876	1	0.20265	1	0.84162	1	0.33317	1
C9ORF66	5 (8%)	57	1	1	0.92754	1	1	1	NA	NA	1	1	0.51246	1	0.57585	1	0.93572	1	0.3482	1	0.54158	1
POLRMT	4 (6%)	58	0.30461	1	0.02993	1	0.087302	1	0.3479	1	0.36329	1	0.059619	1	0.24187	1	0.25832	1	0.35608	1	0.17479	1
ADAMTS7	4 (6%)	58	0.20014	1	0.47859	1	0.087302	1	0.34825	1	0.089399	1	0.43514	1	0.082039	1	0.25666	1	0.12161	1	0.03757	1
BTNL9	4 (6%)	58	1	1	0.112	1	1	1	NA	NA	0.14382	1	0.097499	1	0.13034	1	1	1	0.25453	1	1	1
NF1	7 (11%)	55	0.25145	1	0.90288	1	0.10159	1	0.39389	1	0.36149	1	0.19212	1	0.28098	1	0.88613	1	1	1	0.099559	1
ZNF814	3 (5%)	59	1	1	NA	NA	1	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
RNF135	3 (5%)	59	0.75233	1	NA	NA	0.46429	1	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA
CSGALNACT2	3 (5%)	59	0.16114	1	0.03634	1	0.46429	1	NA	NA	0.77264	1	0.81319	1	0.5814	1	0.8751	1	0.34999	1	0.40398	1
SPIRE2	3 (5%)	59	0.30008	1	0.03822	1	1	1	NA	NA	1	1	0.81536	1	1	1	0.7919	1	1	1	1	1
CYP4A22	4 (6%)	58	0.17723	1	0.70581	1	1	1	NA	NA	0.16755	1	0.48317	1	0.17926	1	0.1967	1	0.082549	1	0.61727	1
HLA-A	3 (5%)	59	1	1	1	1	1	1	NA	NA	0.85561	1	0.19279	1	1	1	0.50562	1	0.77737	1	0.25435	1
GLI3	5 (8%)	57	0.8587	1	0.43257	1	NA	NA	NA	NA	0.91082	1	0.87686	1	0.12456	1	0.41457	1	0.29022	1	0.25799	1
