rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(2)	51556	2	2	2	0	1	0	0	1	0	0	0.590	0.0885	1.000
2	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	GNGT1(1), HTR2C(1), PLCB1(8), TUB(2)	517190	12	9	10	7	2	1	0	3	6	0	0.904	0.216	1.000
3	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3D(1), CD3G(2)	84242	3	3	3	3	0	1	0	1	1	0	0.943	0.586	1.000
4	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	AOC2(2), AOC3(4), CES1(12), ESD(2)	444881	20	8	13	5	6	9	0	2	3	0	0.210	0.618	1.000
5	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(1), GLS2(2)	330026	3	3	2	1	0	0	2	1	0	0	0.645	0.659	1.000
6	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	9	CHUK(1), EIF2S2(1), NFKB1(3), NFKBIA(3), TP53(6)	751321	14	13	13	6	4	4	0	1	5	0	0.735	0.742	1.000
7	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDOB(1), ALDOC(1)	284076	2	2	2	0	1	1	0	0	0	0	0.470	0.754	1.000
8	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(1)	120022	1	1	1	1	1	0	0	0	0	0	0.881	0.758	1.000
9	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPL(2), ALPP(13), ALPPL2(5), FPGS(2), GCH1(1), GGH(3)	518717	26	12	18	8	6	9	3	7	1	0	0.204	0.768	1.000
10	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AASDHPPT(2), AASS(2)	342070	4	4	4	2	0	2	0	1	1	0	0.861	0.787	1.000
11	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(2), CS(5), PC(1)	672578	8	7	5	3	0	0	0	5	3	0	0.681	0.828	1.000
12	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(1), IL12B(2)	222942	3	3	2	9	2	0	0	0	1	0	1.000	0.858	1.000
13	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	9	BPNT1(1), PAPSS1(5), PAPSS2(1), SULT1A2(3), SUOX(1)	613543	11	7	9	2	4	2	0	4	1	0	0.359	0.872	1.000
14	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	SPCS1(1)	225000	1	1	1	3	0	0	0	0	1	0	1.000	0.885	1.000
15	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(4), ITPKA(1), ITPKB(10)	444148	15	10	10	9	3	7	0	3	2	0	0.854	0.890	1.000
16	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(1), GSTZ1(3), HGD(1)	161661	5	4	3	3	1	3	0	1	0	0	0.780	0.942	1.000
17	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	7	MYC(7), SP1(1), SP3(2), TP53(6)	516244	16	10	16	9	2	7	1	4	2	0	0.810	0.945	1.000
18	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(2), GLS(1), PRODH(4)	430702	7	5	6	3	3	1	1	2	0	0	0.649	0.947	1.000
19	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	GRIA2(3)	278637	3	3	3	5	0	0	0	2	1	0	0.999	0.960	1.000
20	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CD3D(1), CD3G(2)	235227	3	3	3	7	0	1	0	1	1	0	0.998	0.961	1.000
21	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(2), SQLE(1)	243414	3	3	3	9	0	0	2	0	1	0	1.000	0.968	1.000
22	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AASDH(8), AASDHPPT(2), AASS(2)	502133	12	8	9	7	2	4	0	4	2	0	0.904	0.969	1.000
23	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRNA1(1), SNAP25(1)	230341	2	2	2	7	0	0	0	1	1	0	0.999	0.975	1.000
24	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(1), CHAT(4), CHKA(1), PDHA2(2), PEMT(4)	503543	12	10	10	5	5	5	1	1	0	0	0.476	0.976	1.000
25	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(4), PNPO(1)	351159	5	5	5	9	1	3	0	0	1	0	0.999	0.981	1.000
26	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	GBA(2), GGT1(6), SHMT1(3), SHMT2(1)	423071	12	12	8	5	3	3	1	4	1	0	0.676	0.987	1.000
27	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	FUT1(1), FUT2(1), FUT3(6), FUT5(6), FUT6(7)	370970	21	9	12	9	8	5	0	7	1	0	0.639	0.987	1.000
28	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYA(1), NFYC(2), RB1(1), SP1(1), SP3(2)	488712	7	6	7	5	1	4	0	0	2	0	0.873	0.987	1.000
29	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CUL1(2), E2F1(2), RB1(1)	618831	5	5	5	6	2	1	0	0	2	0	0.987	0.988	1.000
30	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CDKN1B(1), CUL1(2), E2F1(2), NEDD8(1), RB1(1), SKP2(1)	626122	8	7	8	6	3	1	0	1	3	0	0.934	0.989	1.000
31	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(1), CUL1(2), E2F1(2), RB1(1), SKP2(1)	635036	7	6	7	7	3	1	0	0	3	0	0.972	0.990	1.000
32	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CCL2(1), CSF1(2), MST1R(6), TNF(3)	468866	12	8	10	7	1	5	3	2	1	0	0.838	0.994	1.000
33	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	MTMR1(3), MTMR2(4), PHPT1(1), THTPA(2)	464267	10	8	9	8	2	2	0	5	1	0	0.975	0.996	1.000
34	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(3), ACADM(1), ACADS(1), ACAT1(2), ECHS1(1)	400262	8	8	6	5	0	3	0	4	1	0	0.927	0.997	1.000
35	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	CPS1(5), GLS(1)	565382	6	5	3	6	0	0	0	5	1	0	0.994	0.998	1.000
36	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(3), ECHS1(1), HADHB(1), HSD17B4(4), PPT1(1), PPT2(3)	629310	13	7	8	6	0	8	1	3	1	0	0.724	0.999	1.000
37	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	CLOCK(2), CSNK1E(1), PER1(4)	633431	7	5	6	9	1	2	0	3	1	0	0.999	1.000	1.000
38	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(2), ACAT2(1), BDH1(1), BDH2(2), HMGCS2(1), OXCT1(2), OXCT2(2)	555702	11	8	9	9	3	3	1	3	1	0	0.970	1.000	1.000
39	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(5), EIF2AK4(1), EIF2B5(4), EIF2S2(1), EIF2S3(2), PPP1CA(1)	840952	14	10	11	6	2	3	1	7	1	0	0.801	1.000	1.000
40	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(1), MAPK8(1), NFKB1(3), TNFRSF13B(4), TNFSF13(3), TNFSF13B(1), TRAF3(4), TRAF6(1)	1058732	18	9	14	9	3	11	1	1	2	0	0.815	1.000	1.000
41	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	248	ACVR1C(2), AKT2(1), ATF4(4), BDNF(3), BRAF(3), CACNA1A(3), CACNA1B(7), CACNA1C(8), CACNA1E(5), CACNA1F(6), CACNA1G(2), CACNA1H(15), CACNA1I(1), CACNA1S(8), CACNA2D1(3), CACNA2D2(2), CACNA2D3(1), CACNA2D4(3), CACNB2(2), CACNB4(1), CACNG1(1), CACNG3(1), CACNG6(2), CACNG7(1), CHUK(1), DUSP16(2), DUSP2(7), DUSP4(2), DUSP8(1), ECSIT(3), EGF(4), EGFR(4), ELK1(1), FAS(5), FGF12(1), FGF14(1), FGF16(1), FGF21(2), FGF5(1), FGF6(3), FGFR2(2), FGFR4(6), FLNA(4), FLNB(9), FLNC(7), GRB2(1), IKBKB(2), IL1A(2), IL1R1(1), IL1R2(1), KRAS(3), MAP2K1(2), MAP2K3(4), MAP2K4(1), MAP3K1(7), MAP3K10(1), MAP3K13(1), MAP3K4(1), MAP3K5(1), MAP3K6(5), MAP4K1(1), MAP4K3(2), MAP4K4(1), MAPK11(1), MAPK7(1), MAPK8(1), MAPK8IP1(2), MAPK8IP3(2), MAPKAPK2(1), MAPKAPK5(2), MAPT(16), MEF2C(1), MKNK1(1), MKNK2(3), MOS(2), MYC(7), NF1(2), NFATC2(2), NFATC4(1), NFKB1(3), NFKB2(3), NTRK1(3), PAK2(11), PDGFRB(2), PLA2G2D(1), PLA2G3(4), PLA2G4A(1), PLA2G5(1), PPM1A(1), PPP3CA(1), PPP3CC(1), PRKACA(1), PRKACG(2), PRKCG(2), PRKX(1), PTPN5(3), PTPN7(1), PTPRR(3), RAC1(1), RAC3(1), RAF1(4), RAPGEF2(1), RASA1(2), RASA2(2), RASGRF1(2), RASGRF2(1), RASGRP4(1), RPS6KA1(2), RPS6KA2(1), RPS6KA5(1), RPS6KA6(1), RRAS2(1), SOS1(1), SOS2(1), STK3(2), STK4(1), TAOK1(1), TAOK2(2), TGFB2(1), TNF(3), TP53(6), TRAF6(1), ZAK(3)	22091521	322	43	266	421	103	101	13	71	34	0	1.000	1.000	1.000
42	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	137	ACTB(5), ACTG1(6), CHAD(1), COL11A1(7), COL11A2(5), COL17A1(3), COL1A2(1), COL2A1(3), COL3A1(7), COL4A1(3), COL4A2(5), COL4A4(11), COL5A1(5), COL5A2(5), COL5A3(12), COL6A1(5), COL6A2(6), COL6A3(15), COL6A6(4), COMP(2), DES(2), DSC1(3), DSC2(1), DSC3(8), DSG1(20), DSG2(2), DSG3(6), DSG4(2), FN1(2), GJA1(1), GJA4(5), GJA9(5), GJB3(1), GJB4(3), GJB7(3), GJD2(1), GJD4(1), IBSP(5), ITGA6(4), ITGB4(2), KRT1(4), KRT10(2), KRT12(2), KRT14(4), KRT15(3), KRT16(2), KRT17(1), KRT19(2), KRT2(5), KRT20(2), KRT23(4), KRT24(2), KRT25(3), KRT27(6), KRT28(5), KRT3(6), KRT31(3), KRT32(16), KRT33A(5), KRT33B(5), KRT34(2), KRT35(4), KRT36(3), KRT37(16), KRT38(2), KRT39(4), KRT4(7), KRT40(23), KRT5(7), KRT6A(4), KRT6B(5), KRT6C(7), KRT7(3), KRT71(7), KRT72(10), KRT73(4), KRT74(4), KRT75(5), KRT76(6), KRT77(7), KRT78(4), KRT79(3), KRT81(3), KRT82(5), KRT83(4), KRT84(9), KRT85(1), KRT86(3), KRT9(1), LAMA1(26), LAMA2(8), LAMA3(6), LAMA4(5), LAMA5(27), LAMB1(2), LAMB2(5), LAMB3(4), LAMB4(5), LAMC1(4), LAMC2(3), LAMC3(6), LMNA(3), NES(7), PRPH(2), RELN(9), SPP1(1), THBS1(5), THBS2(1), THBS3(2), THBS4(3), TNC(10), TNN(10), TNR(4), TNXB(14), VTN(2), VWF(11)	18620755	618	42	445	629	203	188	30	145	50	2	1.000	1.000	1.000
43	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	192	ACTB(5), ACTG1(6), ACTN1(3), ACTN2(1), ACTN4(1), AKT2(1), ARHGAP5(2), BCAR1(2), BCL2(1), BIRC2(1), BRAF(3), CAPN2(4), CAV1(1), CAV2(2), CCND1(1), CCND2(2), CCND3(3), CHAD(1), COL11A1(7), COL11A2(5), COL1A2(1), COL2A1(3), COL3A1(7), COL4A1(3), COL4A2(5), COL4A4(11), COL5A1(5), COL5A2(5), COL5A3(12), COL6A1(5), COL6A2(6), COL6A3(15), COL6A6(4), COMP(2), DOCK1(7), EGF(4), EGFR(4), ELK1(1), ERBB2(3), FARP2(10), FLNA(4), FLNB(9), FLNC(7), FLT1(2), FN1(2), GRB2(1), IBSP(5), ILK(1), ITGA1(3), ITGA10(5), ITGA11(7), ITGA2(1), ITGA2B(2), ITGA3(1), ITGA4(5), ITGA5(2), ITGA6(4), ITGA7(1), ITGA8(1), ITGA9(2), ITGB3(3), ITGB4(2), KDR(8), LAMA1(26), LAMA2(8), LAMA3(6), LAMA4(5), LAMA5(27), LAMB1(2), LAMB2(5), LAMB3(4), LAMB4(5), LAMC1(4), LAMC2(3), LAMC3(6), MAP2K1(2), MAPK8(1), MET(2), MYLK(8), PAK2(11), PAK4(2), PAK6(3), PAK7(7), PARVA(1), PARVB(7), PARVG(1), PDGFC(1), PDGFRB(2), PDPK1(1), PIK3CA(2), PIK3CD(1), PIK3CG(3), PIK3R2(1), PIK3R3(1), PIP5K1C(2), PPP1CA(1), PPP1R12A(1), PRKCG(2), PTEN(2), PTK2(2), RAC1(1), RAC3(1), RAF1(4), RAPGEF1(1), RELN(9), RHOA(2), ROCK2(2), SHC2(1), SHC3(1), SOS1(1), SOS2(1), SPP1(1), THBS1(5), THBS2(1), THBS3(2), THBS4(3), TLN1(6), TLN2(6), TNC(10), TNN(10), TNR(4), TNXB(14), VAV1(3), VAV2(3), VAV3(4), VEGFB(1), VEGFC(2), VTN(2), VWF(11)	27771025	523	42	410	718	150	164	28	133	45	3	1.000	1.000	1.000
44	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	237	ADCYAP1R1(4), ADORA1(1), ADORA3(4), ADRA1A(3), ADRA2B(2), ADRA2C(1), ADRB1(1), ADRB2(3), AGTR1(2), AGTR2(3), AVPR1B(3), CALCR(5), CALCRL(2), CCKBR(1), CHRM3(5), CNR2(4), CRHR1(1), CTSG(1), CYSLTR1(1), CYSLTR2(2), DRD2(1), DRD3(1), DRD5(5), EDNRA(1), F2(1), F2R(1), F2RL2(1), F2RL3(1), FPR1(8), FSHR(5), GABBR1(1), GABBR2(3), GABRA1(2), GABRA2(2), GABRA3(1), GABRA4(4), GABRA5(1), GABRA6(3), GABRB1(1), GABRD(2), GABRE(1), GABRG3(6), GABRP(2), GABRQ(4), GABRR1(5), GABRR2(2), GALR1(3), GALR2(1), GALR3(1), GH1(2), GH2(1), GHR(2), GHRHR(2), GHSR(1), GIPR(1), GLP1R(3), GLP2R(3), GLRB(1), GPR156(1), GPR35(1), GPR50(7), GPR63(1), GRIA2(3), GRID1(7), GRID2(5), GRIK1(3), GRIK2(1), GRIK3(1), GRIK4(3), GRIK5(1), GRIN2A(2), GRIN2B(2), GRIN2C(3), GRIN2D(1), GRIN3A(13), GRIN3B(10), GRM1(2), GRM2(1), GRM4(1), GRM5(1), GRM6(5), GRM7(1), GRM8(6), HCRTR1(2), HCRTR2(2), HRH1(1), HRH2(1), HRH4(3), HTR1B(2), HTR1F(3), HTR2A(2), HTR2C(1), HTR4(1), HTR5A(1), HTR7(1), LEPR(10), LHB(3), LHCGR(3), MAS1(1), MC1R(4), MC3R(2), MC5R(1), MCHR1(2), MTNR1A(2), MTNR1B(2), NMUR1(2), NMUR2(2), NPBWR1(3), NPBWR2(2), NPFFR2(2), NPY2R(1), NTSR2(1), OPRK1(1), OPRM1(2), OXTR(1), P2RX3(5), P2RX4(2), P2RX5(4), P2RX7(15), P2RY1(1), P2RY10(1), P2RY11(3), P2RY13(1), P2RY2(5), P2RY4(1), P2RY6(1), P2RY8(10), PARD3(2), PRLHR(1), PRLR(2), PRSS1(4), PRSS3(8), PTAFR(2), PTGFR(1), PTGIR(2), PTH2R(2), RXFP2(4), SCTR(1), SSTR1(1), SSTR2(1), SSTR3(1), SSTR4(6), SSTR5(3), TAAR2(1), TAAR6(2), TAAR8(1), TACR2(4), TACR3(1), THRA(1), THRB(2), TRPV1(5), TSHR(3), VIPR2(1)	16350895	395	41	313	460	85	141	26	119	24	0	1.000	1.000	1.000
45	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	145	APC(4), AXIN2(4), BTRC(1), CAMK2G(1), CCND1(1), CCND2(2), CCND3(3), CER1(4), CHD8(4), CREBBP(7), CSNK1A1(2), CSNK1A1L(5), CSNK1E(1), CSNK2A1(4), CSNK2B(1), CUL1(2), DAAM2(4), DKK2(2), DVL1(1), EP300(5), FZD1(1), FZD10(1), FZD2(1), FZD3(1), FZD5(2), FZD6(3), FZD7(1), LRP5(2), LRP6(1), MAPK8(1), MMP7(2), MYC(7), NFAT5(1), NFATC1(6), NFATC2(2), NFATC3(1), NFATC4(1), NKD2(2), PLCB1(8), PLCB3(2), PLCB4(2), PPP2CA(1), PPP2R1B(1), PPP2R2B(3), PPP2R2C(1), PPP3CA(1), PPP3CC(1), PRICKLE2(2), PRKACA(1), PRKACG(2), PRKCG(2), PRKX(1), PSEN1(1), RAC1(1), RAC3(1), RHOA(2), ROCK2(2), SENP2(1), SFRP2(3), SFRP4(2), SKP1(1), SMAD3(1), SOX17(1), TBL1XR1(2), TCF7(2), TCF7L1(2), TP53(6), VANGL1(4), VANGL2(1), WNT10A(1), WNT16(4), WNT3A(1), WNT5A(1), WNT7B(1), WNT8B(2), WNT9B(2)	11996207	167	41	148	199	44	48	5	44	26	0	1.000	1.000	1.000
46	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	130	ALCAM(3), CADM1(1), CADM3(1), CD2(1), CD22(2), CD226(4), CD274(1), CD276(7), CD58(1), CD6(8), CD80(2), CD86(1), CD8B(5), CD99(3), CDH1(1), CDH15(2), CDH2(4), CDH3(6), CDH4(2), CDH5(5), CLDN16(6), CLDN18(1), CLDN22(2), CLDN5(2), CLDN6(3), CLDN8(4), CNTN1(2), CNTN2(5), CNTNAP1(2), CTLA4(1), HLA-A(93), HLA-B(42), HLA-C(60), HLA-DMA(4), HLA-DMB(1), HLA-DOB(1), HLA-DPA1(29), HLA-DPB1(23), HLA-DQA1(19), HLA-DQA2(8), HLA-DQB1(30), HLA-DRA(2), HLA-DRB1(46), HLA-DRB5(31), HLA-E(1), HLA-G(5), ICAM1(6), ICAM3(9), ICOSLG(4), ITGA4(5), ITGA6(4), ITGA8(1), ITGA9(2), ITGAL(1), ITGAM(6), L1CAM(1), MADCAM1(14), MPZL1(1), NCAM1(1), NCAM2(5), NEGR1(3), NFASC(5), NLGN1(1), NRCAM(2), NRXN1(2), NRXN2(2), NRXN3(3), PDCD1LG2(2), PTPRC(1), PTPRF(1), PTPRM(1), PVR(3), PVRL1(3), PVRL2(1), SDC3(5), SDC4(5), SELE(3), SELL(3), SELP(6), SELPLG(9), SIGLEC1(4), VCAM1(1), VCAN(21)	10914862	630	41	426	469	101	227	28	226	40	8	1.000	1.000	1.000
47	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	252	ACVR1(1), BMP2(2), BMP7(1), BMPR1A(3), CCL11(1), CCL14(5), CCL15(1), CCL18(1), CCL2(1), CCL23(2), CCL24(3), CCL25(2), CCL27(3), CCL4(3), CCL8(3), CCR1(1), CCR2(3), CCR3(1), CCR6(1), CCR8(5), CD27(3), CLCF1(1), CRLF2(1), CSF1(2), CSF2(1), CSF2RA(2), CSF2RB(3), CSF3R(2), CX3CL1(2), CX3CR1(5), CXCL14(1), CXCL2(1), CXCL3(1), CXCR4(4), CXCR6(1), EDA(1), EDA2R(4), EGF(4), EGFR(4), EPOR(1), FAS(5), FLT1(2), FLT3(1), FLT3LG(1), FLT4(5), GDF5(3), GH1(2), GH2(1), GHR(2), IFNA1(2), IFNA10(4), IFNA13(1), IFNA14(2), IFNA16(4), IFNA17(1), IFNA4(4), IFNA5(1), IFNAR1(4), IFNAR2(3), IFNGR2(2), IL10RA(4), IL10RB(2), IL11(1), IL12B(2), IL12RB1(8), IL12RB2(2), IL13RA1(1), IL15RA(1), IL17B(1), IL17RA(2), IL17RB(1), IL18R1(1), IL19(1), IL1A(2), IL1R1(1), IL1R2(1), IL20RA(4), IL21R(1), IL22RA1(2), IL22RA2(2), IL23R(2), IL24(3), IL25(1), IL2RA(1), IL2RB(2), IL3(3), IL3RA(4), IL4R(15), IL5RA(2), IL6(2), IL6R(2), IL6ST(4), IL7R(7), IL9(1), IL9R(2), INHBB(1), INHBC(1), INHBE(1), KDR(8), KITLG(1), LEPR(10), LIFR(3), LTA(5), LTB(5), MET(2), NGFR(2), OSMR(2), PDGFC(1), PDGFRB(2), PLEKHO2(5), PRLR(2), TGFB2(1), TNF(3), TNFRSF10A(7), TNFRSF10B(4), TNFRSF10C(7), TNFRSF10D(1), TNFRSF11A(3), TNFRSF11B(2), TNFRSF13B(4), TNFRSF14(6), TNFRSF18(3), TNFRSF19(4), TNFRSF1B(3), TNFRSF21(1), TNFRSF6B(1), TNFRSF8(6), TNFSF13(3), TNFSF13B(1), TNFSF15(1), TNFSF4(1), TNFSF9(1), TPO(10), VEGFB(1), VEGFC(2), XCL1(2)	13120864	357	40	270	288	57	138	28	110	24	0	1.000	1.000	1.000
48	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	127	ABL1(3), ABLIM1(2), ABLIM2(1), ABLIM3(4), ARHGEF12(2), CXCR4(4), DCC(4), EFNA1(1), EFNA3(3), EFNB1(1), EPHA1(3), EPHA2(2), EPHA3(7), EPHA5(3), EPHA6(3), EPHA7(2), EPHA8(1), EPHB1(3), EPHB2(1), EPHB4(2), EPHB6(2), GNAI2(2), KRAS(3), L1CAM(1), LIMK1(1), LIMK2(1), LRRC4C(1), MET(2), NCK1(2), NFAT5(1), NFATC1(6), NFATC2(2), NFATC3(1), NFATC4(1), NGEF(1), NRP1(5), NTN4(4), PAK2(11), PAK4(2), PAK6(3), PAK7(7), PLXNA1(1), PLXNA2(10), PLXNA3(4), PLXNB1(1), PLXNB2(5), PLXNB3(10), PLXNC1(1), PPP3CA(1), PPP3CC(1), PTK2(2), RAC1(1), RAC3(1), RASA1(2), RGS3(4), RHOA(2), ROBO1(2), ROBO2(3), ROBO3(2), ROCK2(2), SEMA3A(1), SEMA3C(3), SEMA3D(4), SEMA3E(4), SEMA3F(1), SEMA3G(1), SEMA4B(2), SEMA4D(5), SEMA4F(1), SEMA4G(1), SEMA5A(2), SEMA5B(6), SEMA6A(2), SEMA6B(2), SEMA6C(2), SEMA6D(7), SEMA7A(1), SLIT1(2), SLIT2(3), SLIT3(4), SRGAP1(2), SRGAP2(2), SRGAP3(1), UNC5B(7), UNC5C(6), UNC5D(1)	14771076	239	39	198	368	74	75	11	69	10	0	1.000	1.000	1.000
49	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	152	AKT2(1), CBL(1), CBLB(1), CBLC(5), CCND1(1), CCND2(2), CCND3(3), CISH(1), CLCF1(1), CREBBP(7), CRLF2(1), CSF2(1), CSF2RA(2), CSF2RB(3), CSF3R(2), EP300(5), EPOR(1), GH1(2), GH2(1), GHR(2), GRB2(1), IFNA1(2), IFNA10(4), IFNA13(1), IFNA14(2), IFNA16(4), IFNA17(1), IFNA4(4), IFNA5(1), IFNAR1(4), IFNAR2(3), IFNGR2(2), IL10RA(4), IL10RB(2), IL11(1), IL12B(2), IL12RB1(8), IL12RB2(2), IL13RA1(1), IL15RA(1), IL19(1), IL20RA(4), IL21R(1), IL22RA1(2), IL22RA2(2), IL23R(2), IL24(3), IL2RA(1), IL2RB(2), IL3(3), IL3RA(4), IL4R(15), IL5RA(2), IL6(2), IL6R(2), IL6ST(4), IL7R(7), IL9(1), IL9R(2), JAK1(2), JAK2(2), JAK3(2), LEPR(10), LIFR(3), MYC(7), OSMR(2), PIAS1(1), PIK3CA(2), PIK3CD(1), PIK3CG(3), PIK3R2(1), PIK3R3(1), PIM1(38), PRLR(2), PTPN6(4), SOCS1(9), SOCS3(1), SOCS7(2), SOS1(1), SOS2(1), SPRED1(1), SPRED2(1), SPRY2(3), SPRY3(1), STAT1(1), STAT2(3), STAT3(8), STAT6(4), TPO(10), TYK2(3)	10729832	283	39	230	218	32	109	23	94	22	3	1.000	1.000	1.000
50	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	126	BRAF(3), CD247(1), CD48(2), CSF2(1), FAS(5), FCGR3A(15), GRB2(1), GZMB(5), HLA-A(93), HLA-B(42), HLA-C(60), HLA-E(1), HLA-G(5), ICAM1(6), IFNA1(2), IFNA10(4), IFNA13(1), IFNA14(2), IFNA16(4), IFNA17(1), IFNA4(4), IFNA5(1), IFNAR1(4), IFNAR2(3), IFNGR2(2), ITGAL(1), KIR2DL3(2), KIR3DL1(16), KIR3DL2(3), KLRC3(8), KLRK1(1), KRAS(3), LCP2(1), MAP2K1(2), MICA(31), MICB(8), NCR1(1), NCR2(3), NCR3(1), NFAT5(1), NFATC1(6), NFATC2(2), NFATC3(1), NFATC4(1), PIK3CA(2), PIK3CD(1), PIK3CG(3), PIK3R2(1), PIK3R3(1), PLCG1(3), PLCG2(5), PPP3CA(1), PPP3CC(1), PRF1(2), PRKCG(2), PTK2B(4), PTPN6(4), RAC1(1), RAC3(1), RAF1(4), SHC2(1), SHC3(1), SOS1(1), SOS2(1), TNF(3), TNFRSF10A(7), TNFRSF10B(4), TNFRSF10C(7), TNFRSF10D(1), ULBP3(2), VAV1(3), VAV2(3), VAV3(4), ZAP70(1)	8385448	435	38	310	334	63	151	18	168	31	4	1.000	1.000	1.000
51	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	63	AKT2(1), BCL10(2), BTK(2), CARD11(12), CD19(2), CD22(2), CD72(2), CD79A(2), CD79B(6), CHUK(1), CR2(7), FCGR2B(1), IKBKB(2), KRAS(3), LILRB3(34), LYN(2), MALT1(1), NFAT5(1), NFATC1(6), NFATC2(2), NFATC3(1), NFATC4(1), NFKB1(3), NFKB2(3), NFKBIA(3), NFKBIB(1), NFKBIE(6), PIK3CA(2), PIK3CD(1), PIK3CG(3), PIK3R2(1), PIK3R3(1), PLCG2(5), PPP3CA(1), PPP3CC(1), PTPN6(4), RAC1(1), RAC3(1), VAV1(3), VAV2(3), VAV3(4)	5567713	140	37	111	135	23	46	5	47	19	0	1.000	1.000	1.000
52	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	203	ACTN1(3), ACTN2(1), ACTN4(1), APC(4), ARHGEF1(1), ARHGEF12(2), ARHGEF4(2), ARPC1B(3), BAIAP2(4), BCAR1(2), BRAF(3), CHRM3(5), CSK(3), DIAPH3(2), DOCK1(7), EGF(4), EGFR(4), EZR(1), F2(1), F2R(1), FGF12(1), FGF14(1), FGF16(1), FGF21(2), FGF5(1), FGF6(3), FGFR2(2), FGFR4(6), FN1(2), GNA13(2), GSN(4), IQGAP2(4), IQGAP3(8), ITGA1(3), ITGA10(5), ITGA11(7), ITGA2(1), ITGA2B(2), ITGA3(1), ITGA4(5), ITGA5(2), ITGA6(4), ITGA7(1), ITGA8(1), ITGA9(2), ITGAD(2), ITGAE(8), ITGAL(1), ITGAM(6), ITGAX(6), ITGB3(3), ITGB4(2), KRAS(3), LIMK1(1), LIMK2(1), MAP2K1(2), MOS(2), MSN(2), MYH10(3), MYH14(4), MYH9(6), MYLK(8), NCKAP1(2), NCKAP1L(1), PAK2(11), PAK4(2), PAK6(3), PAK7(7), PDGFRB(2), PFN1(3), PIK3CA(2), PIK3CD(1), PIK3CG(3), PIK3R2(1), PIK3R3(1), PIP4K2A(3), PIP5K1A(1), PIP5K1B(1), PIP5K1C(2), PPP1CA(1), PPP1R12A(1), PPP1R12B(1), PTK2(2), RAC1(1), RAC3(1), RAF1(4), RHOA(2), ROCK2(2), RRAS2(1), SCIN(5), SOS1(1), SOS2(1), SSH1(2), SSH2(3), SSH3(1), TIAM1(8), TIAM2(9), TMSB4X(7), VAV1(3), VAV2(3), VAV3(4), WAS(1), WASF1(1), WASL(1)	20834515	297	37	237	417	86	90	17	83	20	1	1.000	1.000	1.000
53	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	81	ACVR1(1), ACVRL1(1), AURKB(3), BMPR1A(3), BUB1(1), CDKL1(2), CDKL2(1), CDS1(1), CDS2(1), CLK2(2), CSNK2A1(4), CSNK2B(1), DGKA(1), DGKB(2), DGKD(1), DGKE(1), DGKG(2), DGKH(2), DGKQ(1), DGKZ(4), INPP4A(3), INPP4B(5), INPP5A(2), INPPL1(1), ITPKA(1), ITPKB(10), MAP3K10(1), MOS(2), NEK1(8), NEK3(3), OCRL(1), PAK4(2), PIK3C2A(3), PIK3C2B(1), PIK3C2G(10), PIK3CA(2), PIK3CG(3), PIM2(1), PLCB1(8), PLCB3(2), PLCB4(2), PLCD1(2), PLCG1(3), PLCG2(5), PRKACA(1), PRKACG(2), PRKCD(1), PRKCG(2), PRKCQ(2), PRKD1(3), PRKG1(3), RAF1(4), RPS6KA1(2), RPS6KA2(1), STK11(1)	8511200	138	37	120	214	34	38	7	42	17	0	1.000	1.000	1.000
54	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	169	ADCY2(7), ADCY3(2), ADCY4(2), ADCY8(1), ADCY9(4), ADRA1A(3), ADRA1D(2), ADRB1(1), ADRB2(3), AGTR1(2), ATP2A3(2), ATP2B4(1), AVPR1B(3), BST1(4), CACNA1A(3), CACNA1B(7), CACNA1C(8), CACNA1E(5), CACNA1F(6), CACNA1G(2), CACNA1H(15), CACNA1I(1), CACNA1S(8), CAMK2G(1), CAMK4(1), CCKBR(1), CHRM3(5), CHRNA7(1), CYSLTR1(1), CYSLTR2(2), EDNRA(1), EGFR(4), ERBB2(3), ERBB3(1), ERBB4(4), F2R(1), GNA14(1), GNAS(1), GRIN2A(2), GRIN2C(3), GRIN2D(1), GRM1(2), GRM5(1), HRH1(1), HRH2(1), HTR2A(2), HTR2C(1), HTR4(1), HTR5A(1), HTR7(1), ITPKA(1), ITPKB(10), ITPR1(4), ITPR2(3), ITPR3(2), LHCGR(3), MYLK(8), NOS1(3), OXTR(1), P2RX3(5), P2RX4(2), P2RX5(4), P2RX7(15), PDE1B(1), PDE1C(5), PDGFRB(2), PHKA1(1), PHKB(2), PLCB1(8), PLCB3(2), PLCB4(2), PLCD1(2), PLCD4(2), PLCE1(8), PLCG1(3), PLCG2(5), PPID(2), PPP3CA(1), PPP3CC(1), PRKACA(1), PRKACG(2), PRKCG(2), PRKX(1), PTAFR(2), PTGFR(1), PTK2B(4), RYR1(4), RYR2(9), RYR3(6), SLC25A5(2), SLC25A6(2), SLC8A1(1), SLC8A3(1), SPHK1(1), SPHK2(1), TACR2(4), TACR3(1), TRPC1(1), VDAC3(2)	20645101	293	36	238	523	86	82	17	72	35	1	1.000	1.000	1.000
55	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	130	ACTB(5), ACTG1(6), ACTN1(3), ACTN2(1), ACTN4(1), AKT2(1), AMOTL1(5), ASH1L(2), CGN(5), CLDN16(6), CLDN18(1), CLDN22(2), CLDN5(2), CLDN6(3), CLDN8(4), CSNK2A1(4), CSNK2B(1), CTNNA2(3), CTNNA3(6), CTTN(1), EPB41(2), EPB41L1(1), EPB41L2(1), EPB41L3(6), EXOC4(3), GNAI2(2), HCLS1(7), IGSF5(4), INADL(11), KRAS(3), LLGL1(2), LLGL2(9), MAGI1(3), MAGI2(4), MLLT4(1), MPDZ(6), MYH1(4), MYH10(3), MYH11(5), MYH13(5), MYH14(4), MYH15(6), MYH2(2), MYH3(1), MYH4(14), MYH6(6), MYH7(1), MYH7B(4), MYH8(5), MYH9(6), PARD3(2), PARD6G(1), PPP2CA(1), PPP2R1B(1), PPP2R2B(3), PPP2R2C(1), PPP2R3A(13), PPP2R3B(3), PPP2R4(1), PRKCD(1), PRKCG(2), PRKCQ(2), PTEN(2), RHOA(2), RRAS2(1), SPTAN1(1), SYMPK(2), TJP1(3), TJP2(5), TJP3(5), YES1(1), ZAK(3)	14265675	249	36	196	329	70	77	21	57	21	3	1.000	1.000	1.000
56	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	B2M(15), CALR(1), CANX(1), CD8B(5), CIITA(10), CTSB(4), CTSS(2), HLA-A(93), HLA-B(42), HLA-C(60), HLA-DMA(4), HLA-DMB(1), HLA-DOB(1), HLA-DPA1(29), HLA-DPB1(23), HLA-DQA1(19), HLA-DQA2(8), HLA-DQB1(30), HLA-DRA(2), HLA-DRB1(46), HLA-DRB5(31), HLA-E(1), HLA-G(5), HSP90AA1(2), HSP90AB1(4), IFI30(2), IFNA1(2), IFNA10(4), IFNA13(1), IFNA14(2), IFNA16(4), IFNA17(1), IFNA4(4), IFNA5(1), KIR2DL3(2), KIR3DL1(16), KIR3DL2(3), KIR3DL3(3), KLRC3(8), KLRC4(4), LGMN(1), LTA(5), NFYA(1), NFYC(2), PDIA3(1), RFX5(4), RFXANK(2), RFXAP(1), TAP1(5), TAP2(5)	3444235	523	36	358	292	67	182	24	213	34	3	1.000	1.000	1.000
57	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	73	CDS1(1), CDS2(1), DGKA(1), DGKB(2), DGKD(1), DGKE(1), DGKG(2), DGKH(2), DGKI(5), DGKQ(1), DGKZ(4), IMPA2(1), INPP4A(3), INPP4B(5), INPP5A(2), INPP5B(4), INPPL1(1), ITPKA(1), ITPKB(10), ITPR1(4), ITPR2(3), ITPR3(2), OCRL(1), PI4KA(4), PIK3C2A(3), PIK3C2B(1), PIK3C2G(10), PIK3C3(1), PIK3CA(2), PIK3CD(1), PIK3CG(3), PIK3R2(1), PIK3R3(1), PIP4K2A(3), PIP5K1A(1), PIP5K1B(1), PIP5K1C(2), PLCB1(8), PLCB3(2), PLCB4(2), PLCD1(2), PLCD4(2), PLCE1(8), PLCG1(3), PLCG2(5), PRKCG(2), PTEN(2), SYNJ1(2), SYNJ2(3)	9394739	133	35	116	252	29	38	8	37	21	0	1.000	1.000	1.000
58	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(4), CD36(1), CD44(3), CHAD(1), COL11A1(7), COL11A2(5), COL1A2(1), COL2A1(3), COL3A1(7), COL4A1(3), COL4A2(5), COL4A4(11), COL5A1(5), COL5A2(5), COL5A3(12), COL6A1(5), COL6A2(6), COL6A3(15), COL6A6(4), FN1(2), FNDC1(8), FNDC3A(2), FNDC4(1), GP6(2), GP9(1), HMMR(10), HSPG2(15), IBSP(5), ITGA1(3), ITGA10(5), ITGA11(7), ITGA2(1), ITGA2B(2), ITGA3(1), ITGA4(5), ITGA5(2), ITGA6(4), ITGA7(1), ITGA8(1), ITGA9(2), ITGB3(3), ITGB4(2), LAMA1(26), LAMA2(8), LAMA3(6), LAMA4(5), LAMA5(27), LAMB1(2), LAMB2(5), LAMB3(4), LAMB4(5), LAMC1(4), LAMC2(3), LAMC3(6), RELN(9), SDC3(5), SDC4(5), SPP1(1), SV2B(2), SV2C(3), THBS1(5), THBS2(1), THBS3(2), THBS4(3), TNC(10), TNN(10), TNR(4), TNXB(14), VTN(2), VWF(11)	16915114	376	35	290	520	129	117	21	79	27	3	1.000	1.000	1.000
59	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	93	AKT2(1), BCL10(2), CARD11(12), CBL(1), CBLB(1), CBLC(5), CD247(1), CD3D(1), CD3G(2), CD8B(5), CHUK(1), CSF2(1), CTLA4(1), GRAP2(1), GRB2(1), IKBKB(2), KRAS(3), LCP2(1), MALT1(1), NCK1(2), NFAT5(1), NFATC1(6), NFATC2(2), NFATC3(1), NFATC4(1), NFKB1(3), NFKB2(3), NFKBIA(3), NFKBIB(1), NFKBIE(6), PAK2(11), PAK4(2), PAK6(3), PAK7(7), PIK3CA(2), PIK3CD(1), PIK3CG(3), PIK3R2(1), PIK3R3(1), PLCG1(3), PPP3CA(1), PPP3CC(1), PRKCQ(2), PTPN6(4), PTPRC(1), RHOA(2), SOS1(1), SOS2(1), TEC(2), TNF(3), VAV1(3), VAV2(3), VAV3(4), ZAP70(1)	7551386	135	35	113	156	30	39	6	41	19	0	1.000	1.000	1.000
60	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	92	ACTB(5), BCL2(1), CABIN1(4), CAMK4(1), CD3G(2), CDKN1A(4), CREBBP(7), CSF2(1), CSNK2A1(4), CSNK2B(1), CTLA4(1), EGR2(1), EP300(5), FCGR3A(15), GATA3(2), GATA4(2), IFNA1(2), IL2RA(1), IL3(3), IL6(2), JUNB(1), MAPK8(1), MEF2B(3), NFAT5(1), NFATC1(6), NFATC2(2), NFATC3(1), NFATC4(1), NFKB2(3), NFKBIB(1), NFKBIE(6), NUP214(3), P2RX7(15), PPP3CC(1), PTPRC(1), SFN(2), SLA(1), SP1(1), SP3(2), TNF(3), VAV1(3), VAV2(3), VAV3(4), XPO5(2)	6765186	131	34	107	134	28	42	5	39	17	0	1.000	1.000	1.000
61	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	164	ADORA1(1), ADORA3(4), ADRA1A(3), ADRA1D(2), ADRA2C(1), ADRB1(1), ADRB2(3), AGTR1(2), AGTR2(3), AVPR1B(3), CCKBR(1), CCR1(1), CCR2(3), CCR3(1), CCR6(1), CCR8(5), CCRL2(4), CHML(2), CHRM3(5), CMKLR1(1), CNR2(4), CX3CR1(5), CXCR4(4), DRD2(1), DRD3(1), DRD5(5), EDNRA(1), F2R(1), F2RL2(1), F2RL3(1), FPR1(8), FSHR(5), GALR1(3), GALR2(1), GALR3(1), GALT(2), GHSR(1), GPR35(1), GPR37L1(1), GPR50(7), GPR63(1), GPR87(2), HCRTR1(2), HCRTR2(2), HRH1(1), HRH2(1), HTR1B(2), HTR1F(3), HTR2A(2), HTR2C(1), HTR4(1), HTR5A(1), HTR7(1), LHCGR(3), MAS1(1), MC1R(4), MC3R(2), MC5R(1), MTNR1A(2), MTNR1B(2), NMUR1(2), NMUR2(2), NPY2R(1), NTSR2(1), OPRK1(1), OPRM1(2), OR10A5(1), OR11A1(3), OR12D3(5), OR1F1(4), OR1Q1(3), OR2H1(4), OR5V1(4), OR7A5(1), OR7C1(7), OXTR(1), P2RY1(1), P2RY10(1), P2RY11(3), P2RY13(1), P2RY2(5), P2RY6(1), PTAFR(2), PTGFR(1), PTGIR(2), SSTR1(1), SSTR2(1), SSTR3(1), SSTR4(6)	8860857	204	34	162	251	37	77	12	71	7	0	1.000	1.000	1.000
62	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	85	ABL1(3), AKT2(1), BRAF(3), BTC(5), CAMK2G(1), CBL(1), CBLB(1), CBLC(5), CDKN1A(4), CDKN1B(1), EGF(4), EGFR(4), ELK1(1), ERBB2(3), ERBB3(1), ERBB4(4), GAB1(1), GRB2(1), KRAS(3), MAP2K1(2), MAP2K4(1), MAPK8(1), MYC(7), NCK1(2), NRG1(4), NRG2(1), NRG3(2), PAK2(11), PAK4(2), PAK6(3), PAK7(7), PIK3CA(2), PIK3CD(1), PIK3CG(3), PIK3R2(1), PIK3R3(1), PLCG1(3), PLCG2(5), PRKCG(2), PTK2(2), RAF1(4), RPS6KB2(5), SHC2(1), SHC3(1), SOS1(1), SOS2(1)	7685624	123	34	100	169	22	43	10	40	8	0	1.000	1.000	1.000
63	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	110	ABL1(3), ANAPC1(3), ANAPC4(3), ATM(8), ATR(6), BUB1(1), BUB1B(1), CCNA1(1), CCNB2(2), CCNB3(1), CCND1(1), CCND2(2), CCND3(3), CDC14A(1), CDC16(3), CDC25C(4), CDC27(16), CDC6(5), CDKN1A(4), CDKN1B(1), CDKN2A(1), CDKN2B(1), CHEK2(2), CREBBP(7), CUL1(2), DBF4(2), E2F1(2), E2F2(3), E2F3(1), EP300(5), ESPL1(12), FZR1(1), HDAC2(2), MAD1L1(3), MAD2L1(1), MCM3(2), MCM4(2), MCM5(3), MCM7(2), PKMYT1(2), PLK1(1), RB1(1), RBL2(3), SFN(2), SKP1(1), SKP2(1), SMAD3(1), SMC1B(8), TGFB2(1), TP53(6), YWHAE(1)	10111915	151	34	116	130	34	49	2	46	18	2	1.000	1.000	1.000
64	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	82	AKT2(1), ATM(8), BCL2(1), BIRC2(1), CAPN2(4), CASP10(2), CASP7(3), CASP8(3), CASP9(4), CHUK(1), CSF2RB(3), DFFA(1), ENDOG(2), FAS(5), IKBKB(2), IL1A(2), IL1R1(1), IL3(3), IL3RA(4), IRAK1(3), IRAK2(5), IRAK3(1), IRAK4(4), MYD88(7), NFKB1(3), NFKB2(3), NFKBIA(3), NTRK1(3), PIK3CA(2), PIK3CD(1), PIK3CG(3), PIK3R2(1), PIK3R3(1), PPP3CA(1), PPP3CC(1), PRKACA(1), PRKACG(2), TNF(3), TNFRSF10A(7), TNFRSF10B(4), TNFRSF10C(7), TNFRSF10D(1), TP53(6)	6258653	124	34	94	114	21	47	1	37	18	0	1.000	1.000	1.000
65	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	75	ACP1(4), ACTB(5), ACTG1(6), ACTN1(3), ACTN2(1), ACTN4(1), ACVR1C(2), BAIAP2(4), CDH1(1), CREBBP(7), CSNK2A1(4), CSNK2B(1), CTNNA2(3), CTNNA3(6), CTNND1(1), EGFR(4), EP300(5), ERBB2(3), FARP2(10), FER(3), INSR(2), LMO7(10), MET(2), MLLT4(1), PARD3(2), PTPN1(1), PTPN6(4), PTPRB(8), PTPRF(1), PTPRJ(6), PTPRM(1), PVRL1(3), PVRL2(1), PVRL4(1), RAC1(1), RAC3(1), RHOA(2), SMAD3(1), SNAI1(2), SORBS1(4), SSX2IP(3), TCF7(2), TCF7L1(2), TJP1(3), WAS(1), WASF1(1), WASF3(3), WASL(1), YES1(1)	8839792	145	33	125	172	29	54	8	40	14	0	1.000	1.000	1.000
66	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	67	ADCY8(1), ATF4(4), BRAF(3), CACNA1C(8), CAMK2G(1), CAMK4(1), CREBBP(7), EP300(5), GRIA2(3), GRIN2A(2), GRIN2B(2), GRIN2C(3), GRIN2D(1), GRM1(2), GRM5(1), ITPR1(4), ITPR2(3), ITPR3(2), KRAS(3), MAP2K1(2), PLCB1(8), PLCB3(2), PLCB4(2), PPP1CA(1), PPP1R12A(1), PPP3CA(1), PPP3CC(1), PRKACA(1), PRKACG(2), PRKCG(2), PRKX(1), RAF1(4), RAPGEF3(8), RPS6KA1(2), RPS6KA2(1), RPS6KA6(1)	7567297	96	33	85	187	23	22	4	32	15	0	1.000	1.000	1.000
67	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	99	ADCY2(7), ADCY3(2), ADCY4(2), ADCY6(1), ADCY8(1), ADCY9(4), CAMK2G(1), CREB3L1(2), CREB3L2(1), CREB3L4(2), CREBBP(7), DCT(1), DVL1(1), EDN1(3), EP300(5), FZD1(1), FZD10(1), FZD2(1), FZD3(1), FZD5(2), FZD6(3), FZD7(1), GNAI2(2), GNAS(1), KITLG(1), KRAS(3), MAP2K1(2), MC1R(4), MITF(1), PLCB1(8), PLCB3(2), PLCB4(2), POMC(2), PRKACA(1), PRKACG(2), PRKCG(2), PRKX(1), RAF1(4), TCF7(2), TCF7L1(2), TYR(9), TYRP1(1), WNT10A(1), WNT16(4), WNT3A(1), WNT5A(1), WNT7B(1), WNT8B(2), WNT9B(2)	8132148	114	33	95	167	25	35	6	34	14	0	1.000	1.000	1.000
68	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	89	ACVR1(1), ACVR1C(2), ACVRL1(1), BMP2(2), BMP4(2), BMP5(1), BMP6(1), BMP7(1), BMP8A(1), BMPR1A(3), CDKN2B(1), CHRD(4), COMP(2), CREBBP(7), CUL1(2), EP300(5), GDF5(3), ID3(2), INHBB(1), INHBC(1), INHBE(1), LEFTY1(6), LTBP1(4), MYC(7), NODAL(1), PITX2(1), PPP2CA(1), PPP2R1B(1), PPP2R2B(3), PPP2R2C(1), RBL2(3), RHOA(2), ROCK2(2), RPS6KB2(5), SKP1(1), SMAD3(1), SMAD7(1), SMAD9(3), SMURF1(1), SMURF2(1), SP1(1), TGFB2(1), THBS1(5), THBS2(1), THBS3(2), THBS4(3), TNF(3), ZFYVE9(2)	7290751	107	32	91	118	23	40	3	29	12	0	1.000	1.000	1.000
69	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	99	AKT2(1), CASP8(3), CCL4(3), CD80(2), CD86(1), CHUK(1), IFNA1(2), IFNA10(4), IFNA13(1), IFNA14(2), IFNA16(4), IFNA17(1), IFNA4(4), IFNA5(1), IFNAR1(4), IFNAR2(3), IKBKB(2), IKBKE(4), IL12B(2), IL6(2), IRAK1(3), IRAK4(4), IRF3(3), IRF5(1), IRF7(2), LBP(8), MAP2K1(2), MAP2K3(4), MAP2K4(1), MAPK11(1), MAPK8(1), MYD88(7), NFKB1(3), NFKB2(3), NFKBIA(3), PIK3CA(2), PIK3CD(1), PIK3CG(3), PIK3R2(1), PIK3R3(1), RAC1(1), SPP1(1), STAT1(1), TIRAP(5), TLR1(5), TLR2(2), TLR3(2), TLR4(2), TLR5(4), TLR6(1), TLR7(1), TLR8(2), TNF(3), TRAF3(4), TRAF6(1)	6636559	136	32	110	138	28	50	8	35	15	0	1.000	1.000	1.000
70	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	84	ANPEP(4), CD19(2), CD1A(2), CD1B(1), CD1C(2), CD1D(1), CD1E(3), CD2(1), CD22(2), CD33(10), CD36(1), CD3D(1), CD3G(2), CD44(3), CD5(3), CD8B(5), CR1(18), CR2(7), CSF1(2), CSF2(1), CSF2RA(2), CSF3R(2), EPOR(1), FCER2(3), FLT3(1), FLT3LG(1), GP9(1), HLA-DRA(2), HLA-DRB1(46), HLA-DRB5(31), IL11(1), IL1A(2), IL1R1(1), IL1R2(1), IL2RA(1), IL3(3), IL3RA(4), IL4R(15), IL5RA(2), IL6(2), IL6R(2), IL7R(7), IL9R(2), ITGA1(3), ITGA2(1), ITGA2B(2), ITGA3(1), ITGA4(5), ITGA5(2), ITGA6(4), ITGAM(6), ITGB3(3), KITLG(1), MME(4), TFRC(2), TNF(3), TPO(10)	6159478	251	32	179	179	38	101	20	73	18	1	1.000	1.000	1.000
71	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ADCY2(7), ADCY3(2), ADCY4(2), ADCY6(1), ADCY8(1), ADCY9(4), ADRA1A(3), ADRA1D(2), ADRB1(1), ADRB2(3), ATP1A4(1), ATP2A3(2), CACNA1A(3), CACNA1B(7), CACNA1C(8), CACNA1E(5), CACNA1S(8), CALR(1), CAMK2G(1), CAMK4(1), CASQ1(1), CASQ2(4), CHRM3(5), GJA1(1), GJA4(5), GJB3(1), GJB4(3), GNAI2(2), GNB3(1), GNGT1(1), GRK4(6), GRK5(2), GRK6(1), ITPR1(4), ITPR2(3), ITPR3(2), KCNB1(1), KCNJ3(1), KCNJ5(1), PLCB3(2), PRKACA(1), PRKCD(1), PRKCG(2), PRKCQ(2), PRKD1(3), RGS1(1), RGS11(3), RGS14(2), RGS18(2), RGS3(4), RGS6(1), RGS7(1), RGS9(1), RYR1(4), RYR2(9), RYR3(6), SFN(2), SLC8A1(1), SLC8A3(1)	14188441	157	31	128	361	42	55	7	34	18	1	1.000	1.000	1.000
72	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	59	BFAR(4), BTK(2), CAD(1), CASP10(2), CASP8(3), CSNK1A1(2), DFFA(1), EGFR(4), EPHB2(1), FAF1(1), IL1A(2), MAP2K4(1), MAP3K1(7), MAP3K5(1), MAPK8(1), MAPK8IP1(2), MAPK8IP3(2), MET(2), NFAT5(1), NFKB1(3), NFKB2(3), NFKBIA(3), NFKBIB(1), NFKBIE(6), PFN1(3), PTPN13(8), RALBP1(1), TNFRSF6B(1), TP53(6), TPX2(1), TUFM(1)	5537992	77	31	69	95	16	25	4	19	13	0	1.000	1.000	1.000
73	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	57	ASH1L(2), ASH2L(1), CTCFL(5), DOT1L(2), EHMT1(1), EHMT2(2), EZH2(7), JMJD4(3), KDM6A(1), MEN1(1), NSD1(6), PAXIP1(2), PPP1CA(1), PRDM2(7), PRDM6(3), PRDM7(7), PRDM9(18), PRMT6(2), PRMT8(1), SETD1A(1), SETD1B(9), SETD2(3), SETDB2(2), SETMAR(5), SMYD3(3), SUV39H1(1), SUV39H2(1), SUV420H1(1), SUV420H2(1), WHSC1(2), WHSC1L1(1)	9378899	102	30	77	86	19	30	6	37	9	1	1.000	1.000	1.000
74	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	67	BCL2(1), BIRC2(1), CASP1(1), CASP10(2), CASP2(1), CASP4(2), CASP7(3), CASP8(3), CASP9(4), CHUK(1), DFFA(1), FAS(5), GZMB(5), IKBKB(2), IRF1(3), IRF2(1), IRF3(3), IRF4(9), IRF5(1), IRF7(2), LTA(5), MAP2K4(1), MAP3K1(7), MYC(7), NFKB1(3), NFKBIA(3), NFKBIB(1), NFKBIE(6), PLEKHG5(2), PRF1(2), TNF(3), TNFRSF10B(4), TNFRSF1B(3), TNFRSF21(1), TP53(6), TP73(1), TRAF1(2), TRAF3(4)	4332475	112	30	96	94	21	36	7	31	17	0	1.000	1.000	1.000
75	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	83	AGL(6), AMY2A(1), AMY2B(2), ASCC3(5), ATP13A2(1), DDX18(2), DDX23(1), DDX41(2), DDX47(2), DDX51(6), DDX52(4), DDX54(2), DDX55(3), DHX58(5), ENPP1(3), ENPP3(3), ENTPD7(3), EP400(7), ERCC2(4), G6PC2(6), GAA(1), GANC(5), GBA(2), GBE1(3), GUSB(1), GYS2(2), HK1(1), HK2(4), HK3(1), IFIH1(7), LYZL1(1), MGAM(12), MOV10L1(17), NUDT5(1), PGM1(4), PGM3(1), PYGB(6), PYGL(4), RAD54B(2), SETX(8), SI(5), SKIV2L2(2), SMARCA2(8), SMARCA5(1), UGT1A1(2), UGT1A10(1), UGT1A3(4), UGT1A4(1), UGT1A6(7), UGT1A7(6), UGT1A9(3), UGT2A1(9), UGT2B11(9), UGT2B15(3), UGT2B17(2), UGT2B28(8), UGT2B4(2), UGT2B7(4), UXS1(1)	9719884	229	30	165	228	37	79	13	77	23	0	1.000	1.000	1.000
76	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	ADAM17(1), CREBBP(7), DLL3(1), DTX1(4), DTX2(2), DTX3L(3), DTX4(2), DVL1(1), EP300(5), HDAC2(2), JAG1(3), JAG2(4), LFNG(1), MAML1(4), MAML2(3), MAML3(10), NCOR2(9), NOTCH1(2), NOTCH2(10), NOTCH3(5), NOTCH4(10), NUMB(2), NUMBL(1), PSEN1(1), PTCRA(6), RBPJL(6)	5412659	105	30	83	112	22	30	3	35	15	0	1.000	1.000	1.000
77	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	85	BRAF(3), CHUK(1), ELK1(1), GRB2(1), IKBKB(2), MAP2K1(2), MAP2K3(4), MAP2K4(1), MAP3K1(7), MAP3K10(1), MAP3K11(1), MAP3K13(1), MAP3K4(1), MAP3K5(1), MAP3K6(5), MAP4K1(1), MAP4K3(2), MAP4K4(1), MAP4K5(3), MAPK11(1), MAPK4(1), MAPK6(3), MAPK7(1), MAPK8(1), MAPKAPK2(1), MAPKAPK5(2), MEF2B(3), MEF2C(1), MKNK1(1), MKNK2(3), MYC(7), NFKB1(3), NFKBIA(3), PAK2(11), RAC1(1), RAF1(4), RPS6KA1(2), RPS6KA2(1), RPS6KA5(1), RPS6KB2(5), SP1(1), STAT1(1), TGFB2(1)	7345625	98	30	81	133	16	29	9	32	12	0	1.000	1.000	1.000
78	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	137	ADCY2(7), ADCY3(2), ADCY4(2), ADCY6(1), ADCY8(1), ADCY9(4), ATF1(1), ATF4(4), ATF5(2), ATP2A3(2), CALCA(1), CAMK2G(1), CNN1(1), CRHR1(1), DGKZ(4), ETS2(2), GABPB2(1), GBA2(1), GJA1(1), GNB3(1), GNGT1(1), GRK4(6), GRK5(2), GRK6(1), GSTO1(3), GUCA2A(2), GUCA2B(1), GUCY1A3(1), IGFBP1(2), IGFBP3(1), IGFBP4(1), IL6(2), ITPR1(4), ITPR2(3), ITPR3(2), NFKB1(3), NOS1(3), OXTR(1), PLCB3(2), PLCD1(2), PLCG1(3), PLCG2(5), PRKACA(1), PRKCD(1), PRKCQ(2), PRKD1(3), RAMP3(1), RGS1(1), RGS11(3), RGS14(2), RGS18(2), RGS3(4), RGS6(1), RGS7(1), RGS9(1), RYR1(4), RYR2(9), RYR3(6), SFN(2), SLC8A1(1), SP1(1), TNXB(14)	13051165	151	30	126	337	38	60	7	33	12	1	1.000	1.000	1.000
79	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT2(1), ASAH1(4), BRAF(3), DRD2(1), EGFR(4), EPHB2(1), GRB2(1), ITPKA(1), ITPKB(10), ITPR1(4), ITPR2(3), ITPR3(2), KCNJ3(1), KCNJ5(1), KCNJ9(2), PI3(6), PITX2(1), PLCB1(8), PLCB3(2), PLCB4(2), RAF1(4), SOS1(1), SOS2(1), STAT3(8), TERF2IP(1)	4316247	73	30	61	104	18	24	2	17	12	0	1.000	1.000	1.000
80	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	78	ABL1(3), ACTN1(3), AKT2(1), ANGPTL2(1), BCAR1(2), BRAF(3), CAV1(1), CDKN2A(1), DOCK1(7), EPHB2(1), GRB2(1), ILK(1), ITGA1(3), ITGA10(5), ITGA11(7), ITGA2(1), ITGA3(1), ITGA4(5), ITGA5(2), ITGA6(4), ITGA7(1), ITGA8(1), ITGA9(2), MAP2K4(1), MAP3K11(1), MAPK8(1), MAPK8IP1(2), MAPK8IP3(2), MYLK(8), PAK2(11), PAK4(2), PAK6(3), PAK7(7), PIK3CA(2), PLCG1(3), PLCG2(5), PTEN(2), PTK2(2), RAF1(4), ROCK2(2), SOS1(1), SOS2(1), TERF2IP(1), TLN1(6), TLN2(6), WAS(1)	9117849	131	30	104	182	34	43	12	32	9	1	1.000	1.000	1.000
81	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(1), CD3D(1), CSK(3), CTLA4(1), EPHB2(1), GRAP2(1), GRB2(1), ITPKA(1), ITPKB(10), LCP2(1), NCK1(2), NFAT5(1), NFKB1(3), NFKB2(3), NFKBIA(3), NFKBIB(1), NFKBIE(6), PAK2(11), PAK4(2), PAK6(3), PAK7(7), PLCG1(3), PTPRC(1), RAF1(4), RASGRP4(1), SOS1(1), SOS2(1), VAV1(3), ZAP70(1)	4245133	78	30	61	66	16	27	7	17	11	0	1.000	1.000	1.000
82	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(8), ABCA10(3), ABCA12(3), ABCA13(31), ABCA2(3), ABCA3(4), ABCA4(8), ABCA5(3), ABCA7(14), ABCA8(9), ABCA9(1), ABCB1(6), ABCB10(1), ABCB11(2), ABCB5(15), ABCB6(1), ABCB8(6), ABCB9(1), ABCC1(3), ABCC10(2), ABCC11(4), ABCC12(7), ABCC2(4), ABCC3(5), ABCC4(2), ABCC5(3), ABCC6(12), ABCC8(1), ABCD2(1), ABCD4(6), ABCG2(3), ABCG4(3), ABCG5(3), ABCG8(5), CFTR(5), TAP1(5), TAP2(5)	8858326	198	29	150	183	51	63	7	53	24	0	1.000	1.000	1.000
83	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	92	ADCY2(7), ADCY3(2), ADCY4(2), ADCY6(1), ADCY8(1), ADCY9(4), ADRB1(1), DRD2(1), EGF(4), EGFR(4), GJA1(1), GJD2(1), GNAI2(2), GNAS(1), GRB2(1), GRM1(2), GRM5(1), GUCY1A2(2), GUCY1A3(1), GUCY2D(5), GUCY2F(3), HTR2A(2), HTR2C(1), ITPR1(4), ITPR2(3), ITPR3(2), KRAS(3), MAP2K1(2), MAPK7(1), NPR1(2), NPR2(1), PDGFC(1), PDGFRB(2), PLCB1(8), PLCB3(2), PLCB4(2), PRKACA(1), PRKACG(2), PRKCG(2), PRKG1(3), PRKG2(1), PRKX(1), RAF1(4), SOS1(1), SOS2(1), TJP1(3), TUBA1B(1), TUBA1C(1), TUBA3C(3), TUBA3D(4), TUBA3E(8), TUBA8(3), TUBAL3(1), TUBB1(4), TUBB2A(1), TUBB6(2), TUBB8(5)	9863280	135	29	113	244	35	41	6	36	17	0	1.000	1.000	1.000
84	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	131	ACACA(2), ACACB(12), AKT2(1), BRAF(3), CBL(1), CBLB(1), CBLC(5), ELK1(1), EXOC7(2), FASN(3), FBP2(2), FOXO1(2), G6PC2(6), GRB2(1), GYS2(2), IKBKB(2), INSR(2), IRS1(2), IRS2(2), IRS4(6), KRAS(3), LIPE(2), MAP2K1(2), MAPK8(1), MKNK1(1), MKNK2(3), PCK1(3), PCK2(1), PDE3A(9), PDPK1(1), PFKM(1), PHKA1(1), PHKB(2), PIK3CA(2), PIK3CD(1), PIK3CG(3), PIK3R2(1), PIK3R3(1), PPARGC1A(2), PPP1CA(1), PPP1R3A(8), PRKAA1(1), PRKACA(1), PRKACG(2), PRKAG3(4), PRKX(1), PTPN1(1), PTPRF(1), PYGB(6), PYGL(4), RAF1(4), RAPGEF1(1), RPS6KB2(5), SHC2(1), SHC3(1), SLC2A4(1), SOCS1(9), SOCS3(1), SORBS1(4), SOS1(1), SOS2(1), SREBF1(1), TRIP10(1), TSC1(4)	12082132	163	29	137	274	41	61	7	37	17	0	1.000	1.000	1.000
85	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	BCAR1(2), CAPN10(1), CAPN11(5), CAPN2(4), CAPN3(1), CAPN6(1), CAPN7(1), CAPN9(7), CAV1(1), CAV2(2), CSK(3), DOCK1(7), GIT2(2), GRB2(1), ILK(1), ITGA10(5), ITGA11(7), ITGA2(1), ITGA2B(2), ITGA3(1), ITGA4(5), ITGA5(2), ITGA6(4), ITGA7(1), ITGA8(1), ITGA9(2), ITGAD(2), ITGAE(8), ITGAL(1), ITGAM(6), ITGAX(6), ITGB3(3), ITGB4(2), MAP2K1(2), MAP2K3(4), MAPK4(1), MAPK6(3), MAPK7(1), PAK2(11), PAK4(2), PAK6(3), PDPK1(1), PIK3R2(1), PTK2(2), RAC1(1), RAC3(1), RAPGEF1(1), ROCK2(2), SDCCAG8(2), SHC3(1), SORBS1(4), SOS1(1), TLN1(6), TNS1(15), VAV2(3), VAV3(4)	10157057	170	29	126	249	50	49	11	47	12	1	1.000	1.000	1.000
86	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	110	ACTN1(3), ACTN2(1), ACTN4(1), ARHGAP5(2), BCAR1(2), CD99(3), CDH5(5), CLDN16(6), CLDN18(1), CLDN22(2), CLDN5(2), CLDN6(3), CLDN8(4), CTNNA2(3), CTNNA3(6), CTNND1(1), CXCR4(4), CYBA(1), CYBB(1), EZR(1), GNAI2(2), ICAM1(6), ITGA4(5), ITGAL(1), ITGAM(6), MAPK11(1), MLLT4(1), MMP2(1), MMP9(3), MSN(2), NCF1(1), NCF2(2), NOX3(2), PIK3CA(2), PIK3CD(1), PIK3CG(3), PIK3R2(1), PIK3R3(1), PLCG1(3), PLCG2(5), PRKCG(2), PTK2(2), PTK2B(4), RAC1(1), RAPGEF3(8), RHOA(2), ROCK2(2), SIPA1(3), TXK(4), VAV1(3), VAV2(3), VAV3(4), VCAM1(1)	9309365	140	28	105	189	32	40	11	36	17	4	1.000	1.000	1.000
87	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	BRAF(3), CACNA1A(3), CRHR1(1), GNA13(2), GNAI2(2), GNAS(1), GRIA2(3), GRID2(5), GRM1(2), GRM5(1), GUCY1A2(2), GUCY1A3(1), GUCY2D(5), GUCY2F(3), ITPR1(4), ITPR2(3), ITPR3(2), KRAS(3), LYN(2), MAP2K1(2), NOS1(3), NPR1(2), NPR2(1), PLA2G2D(1), PLA2G3(4), PLA2G4A(1), PLA2G5(1), PLCB1(8), PLCB3(2), PLCB4(2), PPP2CA(1), PPP2R1B(1), PPP2R2B(3), PPP2R2C(1), PRKCG(2), PRKG1(3), PRKG2(1), RAF1(4), RYR1(4)	8299633	95	28	85	204	25	26	7	24	13	0	1.000	1.000	1.000
88	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	95	ADCY2(7), ADCY3(2), ADCY4(2), ADCY6(1), ADCY8(1), ADCY9(4), ATF4(4), CACNA1C(8), CACNA1F(6), CACNA1S(8), CAMK2G(1), EGFR(4), ELK1(1), GNAS(1), GNRH1(3), GNRH2(2), GRB2(1), ITPR1(4), ITPR2(3), ITPR3(2), KRAS(3), LHB(3), MAP2K1(2), MAP2K3(4), MAP2K4(1), MAP3K1(7), MAP3K4(1), MAPK11(1), MAPK7(1), MAPK8(1), MMP14(4), MMP2(1), PLA2G2D(1), PLA2G3(4), PLA2G4A(1), PLA2G5(1), PLCB1(8), PLCB3(2), PLCB4(2), PLD1(4), PLD2(13), PRKACA(1), PRKACG(2), PRKCD(1), PRKX(1), PTK2B(4), RAF1(4), SOS1(1), SOS2(1)	9679478	145	28	118	240	35	44	9	35	22	0	1.000	1.000	1.000
89	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	71	ACACB(12), ACSL3(2), ACSL5(2), ADIPOQ(2), ADIPOR2(1), AKT2(1), CAMKK1(1), CAMKK2(5), CD36(1), CHUK(1), CPT1B(4), CPT1C(1), CPT2(5), G6PC2(6), IKBKB(2), IRS1(2), IRS2(2), IRS4(6), JAK1(2), JAK2(2), JAK3(2), LEPR(10), MAPK8(1), NFKB1(3), NFKB2(3), NFKBIA(3), NFKBIB(1), NFKBIE(6), NPY(1), PCK1(3), PCK2(1), POMC(2), PPARA(1), PPARGC1A(2), PRKAA1(1), PRKAG3(4), PRKCQ(2), SLC2A4(1), SOCS3(1), STAT3(8), STK11(1), TNF(3), TNFRSF1B(3), TYK2(3)	6213649	126	28	98	149	32	35	12	34	13	0	1.000	1.000	1.000
90	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	66	ADAM10(1), ADAM17(1), ATP6V0A1(2), ATP6V0A2(2), ATP6V0A4(1), ATP6V0B(1), ATP6V0D2(1), ATP6V1A(1), ATP6V1B1(2), ATP6V1C2(2), ATP6V1G3(1), ATP6V1H(1), CHUK(1), CSK(3), EGFR(4), IGSF5(4), IKBKB(2), LYN(2), MAP2K4(1), MAPK11(1), MAPK8(1), MET(2), NFKB1(3), NFKB2(3), NFKBIA(3), NOD1(3), PLCG1(3), PLCG2(5), PTPRZ1(13), RAC1(1), TCIRG1(2), TJP1(3)	5259254	76	28	64	95	23	18	7	17	11	0	1.000	1.000	1.000
91	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(1), CREBBP(7), EP300(5), IKBKB(2), MAP2K3(4), MAPK11(1), MYD88(7), NFKB1(3), NFKBIA(3), TLR2(2), TNF(3)	2183744	38	28	33	23	6	9	1	8	14	0	0.980	1.000	1.000
92	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	63	AKT2(1), CDKN1B(1), CDKN2A(1), ERBB4(4), F2RL2(1), GAB1(1), GRB2(1), IGFBP1(2), INPPL1(1), IRS1(2), IRS2(2), IRS4(6), MET(2), MYC(7), NOLC1(2), PAK2(11), PAK4(2), PAK6(3), PAK7(7), PARD3(2), PIK3CA(2), PIK3CD(1), PREX1(8), PTEN(2), PTK2(2), PTPN1(1), RPS6KA1(2), RPS6KA2(1), SFN(2), SLC2A4(1), SOS1(1), SOS2(1), TSC1(4), YWHAE(1)	5630802	88	28	68	130	15	29	6	29	9	0	1.000	1.000	1.000
93	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	AKT2(1), BCR(1), BTK(2), CD19(2), CSK(3), EPHB2(1), GRB2(1), ITPKA(1), ITPKB(10), LYN(2), MAP2K1(2), NFAT5(1), NFKB1(3), NFKB2(3), NFKBIA(3), NFKBIB(1), NFKBIE(6), PI3(6), PIK3CA(2), PIK3CD(1), PLCG2(5), RAF1(4), SOS1(1), SOS2(1), VAV1(3)	3924619	66	28	58	87	20	16	3	14	13	0	1.000	1.000	1.000
94	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	91	ADCY2(7), ADCY3(2), ADCY4(2), ADCY6(1), ADCY8(1), ADCY9(4), AKAP1(4), AKAP10(3), AKAP11(5), AKAP12(10), AKAP2(5), AKAP3(4), AKAP4(3), AKAP5(2), AKAP6(8), AKAP7(3), AKAP9(8), ARHGEF1(1), GNA13(2), GNA14(1), GNAI2(2), GNB3(1), GNGT1(1), IL18BP(1), ITPR1(4), KCNJ3(1), KRAS(3), PALM2(1), PDE1B(1), PDE1C(5), PDE4A(3), PDE4C(2), PLCB3(2), PPP3CA(1), PPP3CC(1), PRKACA(1), PRKACG(2), PRKCD(1), PRKCG(2), PRKCQ(2), PRKD1(3), PRKD3(2), RHOA(2)	8578753	120	27	105	182	27	48	5	32	7	1	1.000	1.000	1.000
95	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	53	ADORA3(4), ALG6(4), CCKBR(1), CCR2(3), CCR3(1), CELSR1(21), CELSR2(1), CELSR3(3), CHRM3(5), CIDEB(1), EDNRA(1), EMR2(4), EMR3(4), F2R(1), FSHR(5), GHRHR(2), GPR116(5), GPR133(4), GPR18(1), GPR55(3), GPR56(4), GRM1(2), HRH4(3), LGR6(3), LPHN2(3), LPHN3(1), P2RY11(3), P2RY13(1), PTGFR(1), SMO(2), SSTR2(1), TSHR(3), VN1R1(9)	4908410	110	27	84	109	21	39	7	42	1	0	1.000	1.000	1.000
96	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	28	BRAF(3), CPEB1(1), EGFR(4), ERBB2(3), ERBB4(4), ETS1(1), ETS2(2), ETV6(1), ETV7(2), FMN2(14), GRB2(1), KRAS(3), MAP2K1(2), NOTCH1(2), NOTCH2(10), NOTCH3(5), NOTCH4(10), PIWIL1(4), PIWIL3(2), PIWIL4(6), RAF1(4), SOS1(1), SOS2(1), SPIRE2(1)	3918907	87	27	66	97	15	32	2	30	7	1	1.000	1.000	1.000
97	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	69	A2M(4), C1S(4), C3(5), C4A(6), C4B(2), C4BPA(4), C5(6), C6(3), C7(7), C8A(9), C8B(3), C9(2), CFB(2), CFH(4), CFI(2), CPB2(2), CR1(18), CR2(7), F10(1), F11(1), F12(1), F13A1(8), F13B(1), F2(1), F2R(1), F5(18), F7(3), F8(3), F9(1), FGA(2), FGB(1), FGG(1), KLKB1(4), KNG1(6), MASP1(1), MASP2(4), MBL2(4), PLAT(1), PLAUR(4), PLG(4), PROC(2), PROS1(1), SERPINA1(3), SERPINA5(6), SERPINC1(1), SERPIND1(2), SERPINE1(1), SERPINF2(8), SERPING1(1), THBD(1), VWF(11)	7751213	198	27	140	168	43	89	6	48	12	0	1.000	1.000	1.000
98	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG1(6), ANGPTL2(1), FLNA(4), FLNC(7), GDI1(1), LIMK1(1), MYH2(2), MYLK(8), PAK2(11), PAK4(2), PAK6(3), PAK7(7), PFN1(3), ROCK2(2), WASF1(1), WASL(1)	3571649	60	27	45	67	13	13	6	25	3	0	1.000	1.000	1.000
99	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	82	ABL1(3), ATM(8), BUB1(1), BUB1B(1), CCNA1(1), CCNB2(2), CCNB3(1), CCND2(2), CCND3(3), CDAN1(7), CDC14A(1), CDC25C(4), CDC6(5), CDH1(1), CDKN1A(4), CDKN2A(1), CHEK2(2), DTX4(2), E2F1(2), E2F2(3), E2F3(1), EP300(5), ESPL1(12), HDAC2(2), HDAC6(2), HDAC8(1), MAD1L1(3), MAD2L1(1), MCM3(2), MCM4(2), MCM5(3), MCM7(2), MPEG1(6), PLK1(1), PTPRA(2), RB1(1), SKP2(1), TBC1D8(3), TP53(6)	8212512	110	26	87	106	29	39	5	23	13	1	1.000	1.000	1.000
100	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	65	ATM(8), CCNA1(1), CCND1(1), CCND2(2), CCND3(3), CCNG2(1), CDKN1A(4), CDKN1B(1), CDKN2A(1), CDKN2B(1), CREB3L1(2), CREB3L4(2), E2F1(2), E2F2(3), E2F3(1), GBA2(1), MCM3(2), MCM4(2), MCM5(3), MCM7(2), MYC(7), MYT1(1), NACA(7), POLA2(1), POLE(4), PRIM1(1), RB1(1), TFDP2(1), TNXB(14), TP53(6)	5741376	86	26	71	95	18	29	4	27	8	0	1.000	1.000	1.000
101	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADCY2(7), ADCY3(2), ADCY4(2), ADCY6(1), ADCY8(1), ADCY9(4), ADSS(1), ADSSL1(3), AK1(1), AK2(2), AK5(1), AK7(3), ALLC(6), AMPD1(7), AMPD3(3), ATIC(1), DCK(1), ENPP1(3), ENPP3(3), ENTPD2(1), ENTPD3(3), ENTPD4(2), ENTPD5(2), ENTPD6(4), GART(3), GDA(2), GMPR(1), GMPS(1), GUCY1A2(2), GUCY1A3(1), GUCY2D(5), GUCY2F(3), NPR1(2), NPR2(1), NT5C(1), NT5C1B(2), NT5C2(1), NT5E(2), NT5M(1), NUDT5(1), NUDT9(1), PAICS(2), PAPSS1(5), PAPSS2(1), PDE10A(1), PDE11A(3), PDE1C(5), PDE2A(1), PDE4A(3), PDE4C(2), PDE5A(2), PDE6H(1), PDE9A(4), PFAS(6), POLA2(1), POLD1(2), POLD3(1), POLD4(1), POLE(4), POLE4(2), POLR1A(3), POLR1B(2), POLR2B(1), POLR2E(1), POLR3A(4), PRIM1(1), PRPS1L1(2), PRUNE(1), RFC5(1), RRM1(1), XDH(6)	12165105	164	26	127	255	44	50	9	47	14	0	1.000	1.000	1.000
102	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	47	IMPA2(1), INPP4A(3), INPP4B(5), INPP5A(2), INPP5B(4), INPPL1(1), ITPKA(1), ITPKB(10), OCRL(1), PI4KA(4), PIK3C3(1), PIK3CA(2), PIK3CD(1), PIK3CG(3), PIP4K2A(3), PIP5K1A(1), PIP5K1B(1), PIP5K1C(2), PLCB1(8), PLCB3(2), PLCB4(2), PLCD1(2), PLCD4(2), PLCE1(8), PLCG1(3), PLCG2(5), PTEN(2), SYNJ1(2), SYNJ2(3)	5547705	85	26	71	137	17	29	6	18	15	0	1.000	1.000	1.000
103	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	108	A4GNT(2), ALG1(6), ALG10(1), ALG11(1), ALG12(1), ALG14(2), ALG3(1), ALG6(4), ALG8(3), ALG9(1), B3GNT1(1), B3GNT6(1), B3GNT7(2), B4GALT2(1), B4GALT3(2), B4GALT4(1), B4GALT5(1), C1GALT1C1(1), CHST11(1), CHST12(4), CHST13(2), CHST2(1), CHST4(2), CHST6(1), CHSY1(3), DPAGT1(2), EXT1(1), EXT2(1), EXTL1(2), EXTL3(1), FUT8(4), GALNT1(1), GALNT10(1), GALNT12(1), GALNT2(2), GALNT4(5), GALNT5(1), GALNT6(1), GALNT8(8), GALNT9(1), GALNTL5(5), GANAB(3), GCNT1(4), GCNT4(2), HS3ST1(1), HS3ST3B1(1), HS3ST5(1), HS6ST1(3), HS6ST2(1), HS6ST3(2), MAN1A2(1), MAN1B1(1), MAN1C1(1), MAN2A1(1), MGAT1(6), MGAT4A(2), MGAT5(1), MGAT5B(2), NDST1(1), NDST3(1), RPN2(1), ST3GAL4(3), ST6GAL1(3), ST6GALNAC1(3), STT3B(1), UST(1), WBSCR17(1), XYLT1(4), XYLT2(5)	8188685	140	26	114	177	29	51	5	46	9	0	1.000	1.000	1.000
104	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	65	ATM(8), ATR(6), CASP8(3), CASP9(4), CCNB2(2), CCNB3(1), CCND1(1), CCND2(2), CCND3(3), CCNG1(1), CCNG2(1), CD82(1), CDKN1A(4), CDKN2A(1), CHEK2(2), DDB2(1), EI24(4), FAS(5), GTSE1(6), IGFBP3(1), PERP(2), PTEN(2), SERPINB5(2), SERPINE1(1), SESN1(2), SFN(2), THBS1(5), TNFRSF10B(4), TP53(6), TP73(1)	4868807	84	26	65	77	12	40	2	20	9	1	1.000	1.000	1.000
105	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(1), IFNA1(2), IKBKB(2), IL1A(2), IL1R1(1), IL6(2), IRAK1(3), IRAK2(5), IRAK3(1), MAP2K3(4), MAP3K1(7), MAPK8(1), MYD88(7), NFKB1(3), NFKBIA(3), TGFB2(1), TNF(3), TRAF6(1)	2181499	49	26	42	38	12	14	2	8	13	0	0.999	1.000	1.000
106	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	22	CHUK(1), IKBKB(2), IL1A(2), IL1R1(1), IRAK1(3), MAP3K1(7), MYD88(7), NFKB1(3), NFKBIA(3), TLR4(2), TNF(3), TNFAIP3(8), TNFRSF1B(3), TRAF6(1)	1847818	46	26	40	27	7	14	0	8	17	0	0.987	1.000	1.000
107	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	42	BCL2(1), BIRC2(1), CASP2(1), CASP7(3), CASP8(3), CASP9(4), FAS(5), GZMB(5), MAP2K4(1), MAP3K1(7), MCL1(1), MYC(7), NFKB1(3), NFKBIA(3), PARP1(2), PRF1(2), TNF(3), TNFRSF1B(3), TP53(6), TRAF1(2)	2779701	63	25	53	66	12	18	5	18	10	0	1.000	1.000	1.000
108	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	ACTG1(6), BCL2(1), BIRC2(1), CASP2(1), CASP7(3), CASP8(3), CASP9(4), CHUK(1), DFFA(1), GSN(4), LMNA(3), MAP3K1(7), MAP3K5(1), MAPK8(1), NFKB1(3), NFKBIA(3), NUMA1(2), PAK2(11), PRKCD(1), PSEN1(1), PTK2(2), RASA1(2), RB1(1), SPTAN1(1), TNF(3), TNFRSF1B(3), TRAF1(2)	5181088	72	25	55	99	12	18	5	27	10	0	1.000	1.000	1.000
109	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	73	AKT2(1), BTK(2), CSF2(1), GRB2(1), IL3(3), KRAS(3), LCP2(1), LYN(2), MAP2K1(2), MAP2K3(4), MAP2K4(1), MAPK11(1), MAPK8(1), PIK3CA(2), PIK3CD(1), PIK3CG(3), PIK3R2(1), PIK3R3(1), PLA2G2D(1), PLA2G3(4), PLA2G4A(1), PLA2G5(1), PLCG1(3), PLCG2(5), PRKCD(1), RAC1(1), RAC3(1), RAF1(4), SOS1(1), SOS2(1), TNF(3), VAV1(3), VAV2(3), VAV3(4)	5257182	68	25	62	129	14	24	7	16	7	0	1.000	1.000	1.000
110	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	INPP4A(3), INPP4B(5), INPP5A(2), INPPL1(1), ITPKA(1), ITPKB(10), OCRL(1), PIK3C2A(3), PIK3C2B(1), PIK3C2G(10), PIK3CA(2), PIK3CG(3), PLCB1(8), PLCB3(2), PLCB4(2), PLCD1(2), PLCG1(3), PLCG2(5)	3347357	64	25	53	98	15	14	4	18	13	0	1.000	1.000	1.000
111	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	B2M(15), HLA-A(93), KLRC3(8), KLRC4(4), MAP2K1(2), PIK3CA(2), PTK2B(4), PTPN6(4), RAC1(1), VAV1(3)	1386527	136	25	94	83	12	39	6	61	17	1	1.000	1.000	1.000
112	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	AKT2(1), BCL2(1), BCR(1), BTK(2), CD19(2), CD22(2), CR2(7), CSK(3), GRB2(1), ITPR1(4), ITPR2(3), ITPR3(2), LYN(2), MAP4K1(1), NFATC1(6), NFATC2(2), PIK3CA(2), PIK3CD(1), PLCG2(5), PPP3CA(1), PPP3CC(1), PTPRC(1), RAF1(4), SOS1(1), SOS2(1), VAV1(3)	5419191	60	25	54	132	13	22	1	15	9	0	1.000	1.000	1.000
113	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	32	CHUK(1), ELK1(1), IKBKB(2), IRAK1(3), MAP2K3(4), MAP2K4(1), MAP3K1(7), MAPK8(1), MYD88(7), NFKB1(3), NFKBIA(3), PPARA(1), TIRAP(5), TLR10(5), TLR2(2), TLR3(2), TLR4(2), TLR6(1), TLR7(1), TRAF6(1)	2740455	53	25	45	42	10	20	3	9	11	0	1.000	1.000	1.000
114	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	BTK(2), ELK1(1), GRB2(1), LYN(2), MAP2K1(2), MAP2K4(1), MAP3K1(7), MAPK8(1), NFATC1(6), NFATC2(2), NFATC3(1), NFATC4(1), PAK2(11), PIK3CA(2), PLA2G4A(1), PLCG1(3), PPP3CA(1), PPP3CC(1), RAF1(4), SOS1(1), VAV1(3)	3140558	54	24	42	63	8	17	8	16	5	0	1.000	1.000	1.000
115	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(4), ARSD(19), ARSE(1), CYP11B1(3), CYP11B2(5), HEMK1(1), HSD17B1(2), HSD17B12(2), HSD17B7(4), HSD3B1(2), HSD3B2(2), LCMT1(1), LCMT2(1), METTL2B(3), PRMT2(1), PRMT6(2), PRMT8(1), SULT2B1(3), UGT1A1(2), UGT1A10(1), UGT1A3(4), UGT1A4(1), UGT1A6(7), UGT1A7(6), UGT1A9(3), UGT2A1(9), UGT2B11(9), UGT2B15(3), UGT2B17(2), UGT2B28(8), UGT2B4(2), UGT2B7(4)	3537887	118	24	82	102	17	45	4	43	9	0	1.000	1.000	1.000
116	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(3), ANAPC4(3), BTRC(1), CDC16(3), CDC27(16), CUL1(2), FZR1(1), ITCH(1), SKP1(1), SKP2(1), SMURF1(1), SMURF2(1), UBA1(2), UBE2D3(1), UBE2E3(1), WWP2(1)	3026471	39	24	28	52	7	9	0	14	8	1	1.000	1.000	1.000
117	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	52	AGT(4), CALR(1), CAMK1G(1), CAMK4(1), CREBBP(7), CSNK1A1(2), EDN1(3), ELSPBP1(11), F2(1), GATA4(2), MAP2K1(2), MAPK8(1), MEF2C(1), MYH2(2), NFATC1(6), NFATC2(2), NFATC3(1), NFATC4(1), NKX2-5(1), NPPA(1), PIK3CA(2), PPP3CA(1), PPP3CC(1), PRKACG(2), RAF1(4)	3721089	61	24	47	65	24	12	4	16	5	0	1.000	1.000	1.000
118	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR1(2), AGTR2(3), ATP8A1(2), AVPR1B(3), CCKBR(1), CCR1(1), CCR2(3), CCR3(1), CCR6(1), CCR8(5), CX3CR1(5), CXCR4(4), CXCR6(1), EDNRA(1), FPR1(8), FSHR(5), GALR1(3), GALR2(1), GALR3(1), GALT(2), GHSR(1), LHCGR(3), MC1R(4), MC3R(2), MC5R(1), NPY2R(1), NTSR2(1), OPRK1(1), OPRM1(2), OXTR(1), SSTR1(1), SSTR2(1), SSTR3(1), SSTR4(6), TACR2(4), TACR3(1), TSHR(3)	3777692	87	24	69	98	18	31	4	30	4	0	1.000	1.000	1.000
119	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	50	ACOX1(7), APOA1(1), CD36(1), CPT1B(4), CREBBP(7), EHHADH(3), EP300(5), FABP1(2), HSD17B4(4), LPL(1), MYC(7), NCOA1(2), NCOR1(5), NCOR2(9), NFKBIA(3), NRIP1(3), PIK3CA(2), PPARA(1), PRKACG(2), PTGS2(1), RB1(1), SP1(1), TNF(3)	4739156	75	24	68	75	12	28	3	24	8	0	1.000	1.000	1.000
120	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	AKT2(1), ANGPTL2(1), ARHGAP4(2), ARHGEF11(4), BTK(2), GDI1(1), INPPL1(1), ITPR1(4), ITPR2(3), ITPR3(2), LIMK1(1), MYLK(8), PAK2(11), PAK4(2), PAK6(3), PAK7(7), PIK3CA(2), PIK3CD(1), PIK3CG(3), PITX2(1), PTEN(2), RACGAP1(1), ROCK2(2), SAG(5), WASF1(1), WASL(1)	5210714	72	24	56	103	20	18	7	23	4	0	1.000	1.000	1.000
121	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	42	ASAH1(4), ATF1(1), BRAF(3), CREBBP(7), EGR1(1), EGR2(1), EGR4(1), ELK1(1), MAP1B(4), MAP2K4(1), MAPK8(1), MAPK8IP1(2), MAPK8IP3(2), NTRK1(3), OPN1LW(7), PIK3C2G(10), PIK3CA(2), PIK3CD(1), TERF2IP(1), TH(3)	3905858	56	24	48	62	13	22	2	14	5	0	1.000	1.000	1.000
122	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTN2(1), ACTN4(1), DES(2), DMD(8), MYBPC1(3), MYBPC2(10), MYBPC3(4), MYH3(1), MYH6(6), MYH7(1), MYH8(5), MYOM1(13), NEB(16), TMOD1(1), TNNT1(1), TPM1(1), TPM2(1), TTN(121)	10289363	196	24	137	172	64	76	8	34	14	0	1.000	1.000	1.000
123	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	ANKHD1(3), EEF1B2(1), EEF2K(3), EIF2AK1(2), EIF2AK2(1), EIF2AK3(5), EIF2B3(2), EIF2B4(2), EIF2B5(4), EIF2S2(1), EIF2S3(2), EIF4A2(1), EIF4G1(2), EIF4G3(2), EIF5B(2), PABPC1(23), PABPC3(8)	3271411	64	24	51	54	16	16	5	20	7	0	1.000	1.000	1.000
124	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	BCL2(1), BCL2A1(7), BOK(1), CASP1(1), CASP10(2), CASP2(1), CASP4(2), CASP7(3), CASP8(3), CASP9(4), DFFA(1), FAS(5), IKBKE(4), LTA(5), MCL1(1), NFKB1(3), NFKBIA(3), NGFR(2), NTRK1(3), PTPN13(8), TFG(1), TNF(3), TNFRSF1B(3), TRAF1(2), TRAF3(4), TRAF6(1)	3223263	74	23	60	70	16	27	2	20	9	0	1.000	1.000	1.000
125	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	21	ATM(8), ATR(6), BRCA1(12), BRCA2(7), CHEK2(2), FANCA(20), FANCD2(2), FANCE(2), FANCF(1), FANCG(1), HUS1(1), RAD1(3), RAD17(1), RAD50(1), TP53(6)	3182119	73	23	51	50	16	34	5	13	4	1	0.999	1.000	1.000
126	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BTK(2), CD79A(2), CD79B(6), ELK1(1), GRB2(1), LYN(2), MAP2K1(2), MAP3K1(7), MAPK8(1), NFATC1(6), NFATC2(2), NFATC3(1), NFATC4(1), PLCG1(3), PPP3CA(1), PPP3CC(1), RAC1(1), RAF1(4), SOS1(1), VAV1(3)	2789973	48	23	40	55	9	15	5	12	7	0	1.000	1.000	1.000
127	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(4), AGTR2(3), CAMK2G(1), F2(1), GNGT1(1), GRB2(1), JAK2(2), MAP2K1(2), MAPK8(1), MAPT(16), MYLK(8), PLCG1(3), PTK2B(4), RAF1(4), SOS1(1), STAT1(1), STAT3(8)	3109441	61	23	46	76	16	20	7	13	5	0	1.000	1.000	1.000
128	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	DPM2(1), EGFR(4), ELK1(1), GNAS(1), GNGT1(1), GRB2(1), KLK2(1), MAP2K1(2), MKNK1(1), MKNK2(3), MYC(7), NGFR(2), PPP2CA(1), PTPRR(3), RAF1(4), RPS6KA1(2), RPS6KA5(1), SOS1(1), STAT3(8)	2474866	45	23	43	54	8	17	4	13	3	0	1.000	1.000	1.000
129	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CAMK1G(1), ELK1(1), FPR1(8), GNGT1(1), MAP2K1(2), MAP2K3(4), MAP3K1(7), NCF1(1), NCF2(2), NFATC1(6), NFATC2(2), NFATC3(1), NFATC4(1), NFKB1(3), NFKBIA(3), PIK3C2G(10), PLCB1(8), PPP3CA(1), PPP3CC(1), RAC1(1), RAF1(4)	2892818	68	23	55	62	16	15	4	20	13	0	1.000	1.000	1.000
130	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	70	ADH4(4), ADH7(2), ADHFE1(1), AKR1C1(2), AKR1C2(2), AKR1C3(3), AKR1C4(4), ALDH1A3(3), ALDH3A1(1), ALDH3B2(3), CYP1A1(2), CYP1A2(2), CYP1B1(2), CYP2B6(6), CYP2C18(2), CYP2C19(2), CYP2C8(7), CYP2C9(5), CYP2E1(1), CYP2F1(9), CYP2S1(1), CYP3A4(1), CYP3A43(6), CYP3A5(3), CYP3A7(1), DHDH(8), EPHX1(6), GSTA2(7), GSTA3(2), GSTA4(1), GSTM3(3), GSTM5(1), GSTO2(2), GSTP1(1), GSTT2(2), GSTZ1(3), UGT1A1(2), UGT1A10(1), UGT1A3(4), UGT1A4(1), UGT1A6(7), UGT1A7(6), UGT1A9(3), UGT2A1(9), UGT2B11(9), UGT2B15(3), UGT2B17(2), UGT2B28(8), UGT2B4(2), UGT2B7(4)	4158619	172	23	123	115	23	62	5	61	20	1	1.000	1.000	1.000
131	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	CSNK2A1(4), ELK1(1), GRB2(1), IL6(2), IL6R(2), IL6ST(4), JAK1(2), JAK2(2), JAK3(2), MAP2K1(2), RAF1(4), SOS1(1), STAT3(8)	1777262	35	23	34	28	6	14	2	9	4	0	0.998	1.000	1.000
132	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADCY2(7), ADCY3(2), ADCY4(2), ADCY6(1), ADCY8(1), ADSS(1), AK1(1), AK2(2), AK5(1), ALLC(6), AMPD1(7), AMPD3(3), ATIC(1), ATP5F1(1), DCK(1), ENPP1(3), ENPP3(3), ENTPD2(1), GART(3), GDA(2), GMPS(1), GUCY1A2(2), GUCY1A3(1), GUCY2D(5), GUCY2F(3), NPR1(2), NPR2(1), NT5C(1), NT5E(2), NT5M(1), PAICS(2), PAPSS1(5), PAPSS2(1), PDE4A(3), PDE4C(2), PDE5A(2), PDE6C(1), PDE9A(4), PFAS(6), POLD1(2), POLE(4), POLG(2), POLL(1), POLQ(15), POLR1B(2), POLR2B(1), POLR2E(1), POLRMT(4), PRPS1L1(2), PRUNE(1), RRM1(1)	9553111	130	23	103	192	29	41	9	38	13	0	1.000	1.000	1.000
133	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(4), CDR1(2), DGKI(5), IL6ST(4), MRPL19(3), PIGK(1), RPL13(1), RPL14(1), RPL3(1), RPL37(1), RPL3L(2), RPL4(1), RPL5(1), RPL6(1), RPLP2(1), RPS14(2), RPS15(4), RPS6KA1(2), RPS6KA2(1), RPS6KA6(1), RPS6KB2(5), SLC36A2(1), TBC1D10C(1), UBB(1)	3795127	47	23	40	94	6	18	1	14	8	0	1.000	1.000	1.000
134	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	33	AKT2(1), BCR(1), BTK(2), CD19(2), CDKN2A(1), GAB1(1), ITPR1(4), ITPR2(3), ITPR3(2), LYN(2), PIK3CA(2), PITX2(1), PLCG2(5), PREX1(8), PTEN(2), PTPRC(1), RPS6KA1(2), RPS6KA2(1), SAG(5), TEC(2), VAV1(3)	4072491	51	23	43	120	13	13	2	13	10	0	1.000	1.000	1.000
135	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	34	APC(4), AR(6), ASAH1(4), BRAF(3), CCL15(1), EGFR(4), ITPKA(1), ITPKB(10), ITPR1(4), ITPR2(3), ITPR3(2), KCNJ3(1), KCNJ5(1), KCNJ9(2), PIK3CA(2), PIK3CD(1), PITX2(1), PTX3(3), RAF1(4)	3963767	57	23	48	92	12	22	2	14	7	0	1.000	1.000	1.000
136	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(4), EGF(4), EGFR(4), ELK1(1), GRB2(1), JAK1(2), MAP2K1(2), MAP2K4(1), MAP3K1(7), MAPK8(1), PIK3CA(2), PLCG1(3), RAF1(4), RASA1(2), SOS1(1), STAT1(1), STAT3(8)	2745230	48	22	43	46	4	25	6	8	5	0	1.000	1.000	1.000
137	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	ACHE(1), AGPAT1(1), AGPAT2(1), CDS1(1), CDS2(1), CHAT(4), CHKA(1), CHPT1(2), CRLS1(1), DGKA(1), DGKB(2), DGKD(1), DGKE(1), DGKG(2), DGKH(2), DGKI(5), DGKQ(1), DGKZ(4), ESCO1(1), ETNK2(1), GNPAT(2), GPAM(5), GPD1(1), GPD1L(1), GPD2(3), LCAT(1), LYPLA1(1), LYPLA2(1), PCYT1B(1), PEMT(4), PLA2G2D(1), PLA2G3(4), PLA2G4A(1), PLA2G5(1), PLD1(4), PLD2(13), PNPLA3(5), PPAP2B(1), PTDSS2(2)	4960637	86	22	68	88	17	30	5	27	7	0	1.000	1.000	1.000
138	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(3), ALOX12(3), ALOX12B(1), ALOX15(2), ALOX15B(6), CBR3(4), CYP2B6(6), CYP2C18(2), CYP2C19(2), CYP2C8(7), CYP2C9(5), CYP2E1(1), CYP2J2(1), CYP4A11(4), CYP4A22(19), CYP4F2(4), CYP4F3(1), DHRS4(12), EPHX2(6), GGT1(6), GPX5(1), LTA4H(2), PLA2G2D(1), PLA2G3(4), PLA2G4A(1), PLA2G5(1), PTGES2(2), PTGIS(1), PTGS1(3), PTGS2(1), TBXAS1(5)	2960201	117	22	79	78	28	32	10	37	10	0	1.000	1.000	1.000
139	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPL(2), ALPP(13), ALPPL2(5), ASCC3(5), ATP13A2(1), DDX18(2), DDX23(1), DDX41(2), DDX47(2), DDX51(6), DDX52(4), DDX54(2), DDX55(3), DHX58(5), ENTPD7(3), EP400(7), ERCC2(4), FPGS(2), GCH1(1), GGH(3), IFIH1(7), MOV10L1(17), NUDT5(1), RAD54B(2), SETX(8), SKIV2L2(2), SMARCA2(8), SMARCA5(1)	4657327	119	22	84	115	30	41	7	31	10	0	1.000	1.000	1.000
140	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACAA1(3), ACADL(3), ACADM(1), ACOX1(7), ACOX2(1), ACOX3(1), ACSL3(2), ACSL5(2), ADIPOQ(2), ANGPTL4(4), APOA1(1), APOA5(2), AQP7(3), CD36(1), CPT1B(4), CPT1C(1), CPT2(5), CYP27A1(1), CYP4A11(4), CYP4A22(19), CYP8B1(2), EHHADH(3), FABP1(2), FABP3(1), FABP6(2), FABP7(1), HMGCS2(1), ILK(1), LPL(1), OLR1(2), PCK1(3), PCK2(1), PDPK1(1), PLTP(1), PPARA(1), PPARG(3), SCD(2), SLC27A1(1), SLC27A2(2), SLC27A5(8), SLC27A6(2), SORBS1(4), UCP1(2)	4804945	114	22	85	98	29	34	7	39	5	0	1.000	1.000	1.000
141	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	56	BMP2(2), BMP4(2), BMP5(1), BMP6(1), BMP7(1), BMP8A(1), BTRC(1), CSNK1A1(2), CSNK1A1L(5), CSNK1E(1), CSNK1G3(1), GLI1(2), GLI2(6), GLI3(3), LRP2(16), PRKACA(1), PRKACG(2), PRKX(1), PTCH1(4), PTCH2(3), RAB23(1), SHH(1), SMO(2), STK36(11), WNT10A(1), WNT16(4), WNT3A(1), WNT5A(1), WNT7B(1), WNT8B(2), WNT9B(2)	4469825	83	22	68	100	25	23	4	25	6	0	1.000	1.000	1.000
142	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	42	BCL2(1), CHUK(1), EGF(4), EGFR(4), ETS1(1), ETS2(2), HOXA7(3), IKBKB(2), MAP2K1(2), MAP2K3(4), MAP2K4(1), MAP3K1(7), MAP3K5(1), MAPK8(1), NFKB1(3), NFKBIA(3), PPP2CA(1), PRKCD(1), PRKCG(2), PRKCQ(2), RAF1(4), SP1(1), TNF(3), TNFRSF1B(3)	3488884	57	22	50	80	12	24	5	9	7	0	1.000	1.000	1.000
143	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	35	DOCK1(7), ELK1(1), GAB1(1), GRB2(1), ITGA1(3), MAP2K1(2), MAP4K1(1), MAPK8(1), MET(2), PIK3CA(2), PTEN(2), PTK2(2), PTK2B(4), RAF1(4), RASA1(2), SOS1(1), STAT3(8)	3340908	44	22	39	73	3	20	3	10	8	0	1.000	1.000	1.000
144	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	CAV1(1), CHRNA1(1), FLT1(2), FLT4(5), KDR(8), PDE2A(1), PDE3A(9), PRKACG(2), PRKG1(3), PRKG2(1), RYR2(9), SLC7A1(1)	3104373	43	22	35	53	4	17	3	17	2	0	1.000	1.000	1.000
145	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(7), AR(6), ESR2(1), NR0B1(2), NR1H2(2), NR2F2(1), PGR(7), PPARA(1), PPARG(3), RARB(1), RARG(1), ROR1(1), THRA(1), THRB(2), VDR(2)	3152858	38	22	29	77	6	9	3	12	8	0	1.000	1.000	1.000
146	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	27	AKT2(1), ITPKA(1), ITPKB(10), ITPR1(4), ITPR2(3), ITPR3(2), NFKB1(3), NFKB2(3), NFKBIA(3), NFKBIB(1), NFKBIE(6), PITX2(1), PLD1(4), PLD2(13), VN1R1(9)	3441112	64	22	46	75	13	16	4	17	14	0	1.000	1.000	1.000
147	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	38	DUSP4(2), DUSP8(1), GAB1(1), IL1R1(1), MAP2K4(1), MAP3K1(7), MAP3K10(1), MAP3K11(1), MAP3K13(1), MAP3K4(1), MAP3K5(1), MAPK7(1), MAPK8(1), NFATC3(1), PAPPA(4), TP53(6), TRAF6(1), ZAK(3)	3701842	35	22	32	54	13	9	2	8	3	0	1.000	1.000	1.000
148	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	28	BIRC2(1), CASP8(3), MAP2K4(1), NFKB1(3), NFKB2(3), NFKBIA(3), NFKBIB(1), NFKBIE(6), RALBP1(1), TNF(3), TNFAIP3(8), TNFRSF1B(3)	2107986	36	22	34	27	5	6	2	9	14	0	1.000	1.000	1.000
149	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(4), CCND1(1), CCND2(2), CCND3(3), CSNK1E(1), DVL1(1), FZD1(1), FZD10(1), FZD2(1), FZD3(1), FZD5(2), FZD6(3), FZD7(1), LDLR(3), MYC(7), PPP2R5E(1), PRKCD(1), PRKCG(2), PRKCQ(2), PRKD1(3), RAC1(1), RHOA(2), SFRP4(2), TCF7(2), WNT10A(1), WNT16(4), WNT5A(1), WNT7B(1)	4287548	55	22	48	99	14	21	3	11	6	0	1.000	1.000	1.000
150	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	26	BRCA1(12), CCND1(1), CREBBP(7), EP300(5), GRIP1(1), GTF2A1(1), GTF2E1(1), GTF2F1(3), HDAC2(2), HDAC6(2), MEF2C(1), NCOR2(9), NR0B1(2), NRIP1(3), PELP1(6), TBP(2)	3571992	58	21	48	66	14	18	5	13	8	0	1.000	1.000	1.000
151	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(15), CD3D(1), CD3G(2), GZMB(5), HLA-A(93), ICAM1(6), ITGAL(1), PRF1(2)	627337	125	21	86	62	12	38	7	55	12	1	0.979	1.000	1.000
152	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(1), AGPAT1(1), AGPAT2(1), CDS1(1), CDS2(1), CHAT(4), CHKA(1), CLC(1), CPT1B(4), DGKA(1), DGKB(2), DGKD(1), DGKE(1), DGKG(2), DGKH(2), DGKQ(1), DGKZ(4), GNPAT(2), GPD1(1), GPD2(3), LCAT(1), LGALS13(1), LYPLA1(1), LYPLA2(1), PCYT1B(1), PEMT(4), PLA2G3(4), PLA2G4A(1), PLA2G5(1), PLCG1(3), PLCG2(5), PPAP2B(1)	3794789	59	21	52	77	15	17	3	21	3	0	1.000	1.000	1.000
153	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	26	APC(4), CCND1(1), DVL1(1), FZD1(1), GJA1(1), IRAK1(3), LBP(8), MYD88(7), NFKB1(3), PDPK1(1), PIK3CA(2), PPP2CA(1), TIRAP(5), TLR4(2)	2302812	40	21	30	46	7	15	4	5	9	0	1.000	1.000	1.000
154	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ADH4(4), ADH7(2), ADHFE1(1), ALDH1A3(3), ALDH3A1(1), ALDH3B2(3), AOC2(2), AOC3(4), AOX1(4), DBH(7), DCT(1), DDC(3), ECH1(2), ESCO1(1), FAH(1), GOT2(4), GSTZ1(3), HEMK1(1), HGD(1), LCMT1(1), LCMT2(1), METTL2B(3), PNPLA3(5), PRMT2(1), PRMT6(2), PRMT8(1), TAT(2), TH(3), TPO(10), TYR(9), TYRP1(1)	4353652	87	21	66	85	28	31	1	22	5	0	1.000	1.000	1.000
155	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	69	AKT2(1), CASP9(4), KDR(8), KRAS(3), MAP2K1(2), MAPK11(1), MAPKAPK2(1), NFAT5(1), NFATC1(6), NFATC2(2), NFATC3(1), NFATC4(1), PIK3CA(2), PIK3CD(1), PIK3CG(3), PIK3R2(1), PIK3R3(1), PLA2G2D(1), PLA2G3(4), PLA2G4A(1), PLA2G5(1), PLCG1(3), PLCG2(5), PPP3CA(1), PPP3CC(1), PRKCG(2), PTGS2(1), PTK2(2), RAC1(1), RAC3(1), RAF1(4), SH2D2A(2), SHC2(1), SPHK1(1), SPHK2(1)	5424380	72	21	63	113	20	21	6	22	3	0	1.000	1.000	1.000
156	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ADCY4(2), ADCY6(1), ADCY8(1), CACNA1A(3), CACNA1B(7), GNAS(1), GNAT3(1), GNB3(1), GRM4(1), ITPR3(2), KCNB1(1), PRKACA(1), PRKACG(2), PRKX(1), SCNN1A(3), SCNN1B(3), SCNN1G(2), TAS1R1(3), TAS1R2(10), TAS1R3(1), TAS2R1(3), TAS2R14(2), TAS2R16(3), TAS2R38(2), TAS2R39(1), TAS2R4(5), TAS2R40(1), TAS2R41(2), TAS2R42(6), TAS2R43(4), TAS2R46(3), TAS2R5(3), TAS2R50(3), TAS2R7(2), TAS2R8(1), TAS2R9(2), TRPM5(12)	4332525	102	21	75	100	28	35	0	26	13	0	1.000	1.000	1.000
157	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CD2BP2(1), CLK2(2), COL2A1(3), CPSF1(3), DDX20(9), DHX38(1), DHX9(1), DICER1(1), GIPC1(3), METTL3(1), NXF1(3), PRPF18(1), PRPF4(1), PRPF4B(3), PTBP1(1), PTBP2(1), RBM17(1), RBM5(1), RNGTT(1), SF3A2(1), SF3B1(5), SNRPD2(1), SNRPE(1), SPOP(1), SRPK1(1), SRRM1(2), SUPT5H(1)	7805498	51	21	44	144	9	24	1	7	10	0	1.000	1.000	1.000
158	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	49	AKT2(1), BRD4(2), CBL(1), CDKN2A(1), F2RL2(1), GRB2(1), IGFBP1(2), INPPL1(1), IRS1(2), IRS2(2), IRS4(6), LNPEP(3), PARD3(2), PIK3CA(2), PIK3CD(1), PTEN(2), PTPN1(1), RAF1(4), RPS6KA1(2), RPS6KA2(1), SERPINB6(1), SFN(2), SLC2A4(1), SORBS1(4), SOS1(1), SOS2(1), YWHAE(1)	4329199	49	21	43	77	6	24	2	11	6	0	1.000	1.000	1.000
159	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	ANGPTL2(1), DGKA(1), GCA(1), ITGA9(2), ITPKA(1), ITPKB(10), ITPR1(4), ITPR2(3), ITPR3(2), MAP2K1(2), PDE3A(9), PI3(6), PIK3C2G(10), PIK3CA(2), PIK3CD(1), RIPK3(4)	3650365	59	21	47	83	18	12	4	17	8	0	1.000	1.000	1.000
160	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	CD3D(1), CD3G(2), ELK1(1), GRB2(1), MAP2K1(2), MAP2K4(1), MAP3K1(7), MAPK8(1), NFATC1(6), NFATC2(2), NFATC3(1), NFATC4(1), NFKB1(3), NFKBIA(3), PIK3CA(2), PLCG1(3), PPP3CA(1), PPP3CC(1), PTPN7(1), RAC1(1), RAF1(4), RASA1(2), SOS1(1), VAV1(3), ZAP70(1)	3519620	52	21	46	50	10	18	5	11	8	0	1.000	1.000	1.000
161	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	23	APC(4), BTRC(1), CCND1(1), CREBBP(7), CSNK1A1(2), CSNK2A1(4), DVL1(1), FZD1(1), MYC(7), PPP2CA(1)	2234633	29	21	29	34	2	8	2	10	7	0	1.000	1.000	1.000
162	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	CD3D(1), CD3G(2), CREBBP(7), CSK(3), GNAS(1), GNGT1(1), HLA-DRA(2), HLA-DRB1(46), PRKACG(2), PTPRC(1), ZAP70(1)	1715091	67	20	52	46	9	22	2	27	7	0	1.000	1.000	1.000
163	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	19	ABL1(3), ATM(8), BRCA1(12), CDKN1A(4), CHEK2(2), MAPK8(1), NFKB1(3), NFKBIA(3), RAD50(1), TP53(6), TP73(1)	2158141	44	20	36	29	7	21	5	4	6	1	0.983	1.000	1.000
164	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	CD3D(1), CD3G(2), CREBBP(7), CSK(3), GNAS(1), GNGT1(1), HLA-DRA(2), HLA-DRB1(46), PRKACG(2), PTPRC(1), ZAP70(1)	1715091	67	20	52	46	9	22	2	27	7	0	1.000	1.000	1.000
165	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	22	ATM(8), ATR(6), BRCA1(12), CDC25C(4), CDKN1A(4), CHEK2(2), EP300(5), MYT1(1), RPS6KA1(2), TP53(6)	3146291	50	20	38	39	10	22	4	11	2	1	0.999	1.000	1.000
166	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(4), ACP2(3), ACP5(1), ACPT(8), ALPL(2), ALPP(13), ALPPL2(5), CYP1A1(2), CYP1A2(2), CYP2A13(5), CYP2A6(6), CYP2A7(8), CYP2B6(6), CYP2C18(2), CYP2C19(2), CYP2C8(7), CYP2C9(5), CYP2D6(11), CYP2E1(1), CYP2F1(9), CYP2J2(1), CYP3A4(1), CYP3A5(3), CYP3A7(1), CYP4B1(4), PON1(6)	2173728	118	20	81	53	32	33	3	36	14	0	0.786	1.000	1.000
167	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	CAD(1), CDA(2), CTPS2(1), DCK(1), DHODH(1), DPYD(9), DPYS(1), ENTPD3(3), ENTPD4(2), ENTPD5(2), ENTPD6(4), NT5C(1), NT5C1B(2), NT5C2(1), NT5E(2), NT5M(1), POLA2(1), POLD1(2), POLD3(1), POLD4(1), POLE(4), POLE4(2), POLR1A(3), POLR1B(2), POLR2B(1), POLR2E(1), POLR3A(4), PRIM1(1), RFC5(1), RRM1(1), UMPS(2), UPP1(1), UPP2(4)	6027791	66	20	54	137	20	22	2	21	1	0	1.000	1.000	1.000
168	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(1), CHIA(12), CHIT1(11), CTBS(4), CYB5R1(1), CYB5R3(1), GFPT1(1), GFPT2(2), HEXB(5), HK1(1), HK2(4), HK3(1), MTMR1(3), MTMR2(4), NANS(3), NPL(1), PGM3(1), PHPT1(1), UAP1(1)	2117481	58	20	39	63	10	22	0	18	8	0	1.000	1.000	1.000
169	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(3), ACTB(5), ACTG1(6), ARHGEF2(2), CDH1(1), CTTN(1), EZR(1), HCLS1(7), NCK1(2), NCL(4), RHOA(2), ROCK2(2), TLR4(2), TLR5(4), TUBA1B(1), TUBA1C(1), TUBA3C(3), TUBA3D(4), TUBA3E(8), TUBA8(3), TUBAL3(1), TUBB1(4), TUBB2A(1), TUBB6(2), TUBB8(5), WAS(1), WASL(1)	3841125	77	20	61	97	27	16	0	17	17	0	1.000	1.000	1.000
170	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(3), ACTB(5), ACTG1(6), ARHGEF2(2), CDH1(1), CTTN(1), EZR(1), HCLS1(7), NCK1(2), NCL(4), RHOA(2), ROCK2(2), TLR4(2), TLR5(4), TUBA1B(1), TUBA1C(1), TUBA3C(3), TUBA3D(4), TUBA3E(8), TUBA8(3), TUBAL3(1), TUBB1(4), TUBB2A(1), TUBB6(2), TUBB8(5), WAS(1), WASL(1)	3841125	77	20	61	97	27	16	0	17	17	0	1.000	1.000	1.000
171	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	34	BCL2(1), CBL(1), E2F1(2), GRB2(1), IL2RA(1), IL2RB(2), IRS1(2), JAK1(2), JAK3(2), MYC(7), NMI(1), PIK3CA(2), PTPN6(4), RAF1(4), SOCS1(9), SOCS3(1), SOS1(1)	2671180	43	20	42	72	8	18	1	9	7	0	1.000	1.000	1.000
172	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTN1(3), ACTN2(1), BCAR1(2), BCR(1), CAV1(1), CSK(3), GRB2(1), ITGA1(3), MAP2K1(2), MAPK8(1), PPP1R12B(1), PTK2(2), RAF1(4), SOS1(1), TLN1(6)	3511825	32	20	28	55	5	11	3	8	5	0	1.000	1.000	1.000
173	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(4), ELK1(1), GRB2(1), JAK1(2), MAP2K1(2), MAP2K4(1), MAP3K1(7), MAPK8(1), PIK3CA(2), PLCG1(3), RAF1(4), RASA1(2), SOS1(1), STAT1(1), STAT3(8)	2568059	40	20	37	44	3	20	6	6	5	0	1.000	1.000	1.000
174	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	13	CREBBP(7), PML(2), RB1(1), SIRT1(2), SP100(5), TNF(3), TNFRSF1B(3), TP53(6)	1401040	29	20	26	21	5	8	2	6	8	0	0.989	1.000	1.000
175	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	44	AGL(6), AMY2A(1), AMY2B(2), ENPP1(3), ENPP3(3), GAA(1), GANAB(3), GBE1(3), GUSB(1), GYS2(2), HK1(1), HK2(4), HK3(1), MGAM(12), PGM1(4), PGM3(1), PYGB(6), PYGL(4), SI(5), UCHL1(3), UGT1A1(2), UGT1A10(1), UGT1A3(4), UGT1A4(1), UGT1A6(7), UGT1A7(6), UGT1A9(3), UGT2B15(3), UGT2B4(2), UXS1(1)	4897742	96	20	69	99	13	32	4	39	8	0	1.000	1.000	1.000
176	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	15	BCL2(1), EGFR(4), MYC(7), PPP2CA(1), RB1(1), TEP1(24), TERT(1), TNKS(2), TP53(6), XRCC5(2)	2032822	49	20	39	59	13	17	3	12	4	0	1.000	1.000	1.000
177	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	CASP2(1), CASP8(3), DFFA(1), LMNA(3), MADD(6), MAP2K4(1), MAP3K1(7), MAPK8(1), PAK2(11), RB1(1), SPTAN1(1), TNF(3)	2935882	39	20	27	52	8	8	5	11	7	0	1.000	1.000	1.000
178	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	18	CHUK(1), IKBKAP(11), IKBKB(2), LTA(5), MAP3K1(7), NFKB1(3), NFKBIA(3), TANK(2), TNFAIP3(8), TNFRSF1B(3), TRAF1(2), TRAF3(4)	1700324	51	20	39	30	10	18	0	11	12	0	0.993	1.000	1.000
179	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	20	ATM(8), BCL2(1), CASP7(3), CASP9(4), PTK2(2), STAT1(1), TLN1(6), TP53(6)	1997731	31	19	24	31	5	15	1	5	5	0	1.000	1.000	1.000
180	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	BTG1(9), CLDN5(2), CLOCK(2), EIF4G2(1), ETV6(1), GFRA1(1), GSTM3(3), GSTP1(1), HERPUD1(2), MYF6(1), NCKAP1(2), PER1(4), PER2(4), PIGF(1), UCP3(1), ZFR(2)	2694357	37	19	30	53	6	16	0	6	8	1	1.000	1.000	1.000
181	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	16	C1S(4), C3(5), C4A(6), C4B(2), C5(6), C6(3), C7(7), C8A(9), C9(2), MASP1(1), MASP2(4), MBL2(4)	2551455	53	19	42	35	12	21	0	18	2	0	0.994	1.000	1.000
182	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	CASP10(2), CASP7(3), CASP8(3), DFFA(1), FAF1(1), LMNA(3), MAP2K4(1), MAP3K1(7), MAPK8(1), PAK2(11), PTPN13(8), RB1(1), RIPK2(1), SPTAN1(1)	3154006	44	19	32	55	5	13	5	16	5	0	1.000	1.000	1.000
183	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	25	ABL1(3), ATM(8), ATR(6), CCNA1(1), CCND1(1), CDKN1A(4), CDKN1B(1), CDKN2A(1), CDKN2B(1), E2F1(2), RB1(1), SKP2(1), TGFB2(1), TP53(6)	2204101	37	19	32	30	11	13	1	6	6	0	0.999	1.000	1.000
184	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	25	GH1(2), GHR(2), GRB2(1), INSR(2), IRS1(2), JAK2(2), MAP2K1(2), PIK3CA(2), PLCG1(3), PTPN6(4), RAF1(4), RPS6KA1(2), SLC2A4(1), SOCS1(9), SOS1(1)	2443030	39	19	37	53	4	17	3	8	7	0	1.000	1.000	1.000
185	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(3), ATP4A(1), ATP5F1(1), ATP6V0A1(2), ATP6V0A2(2), ATP6V0A4(1), ATP6V0B(1), ATP6V0D2(1), ATP6V1A(1), ATP6V1B1(2), ATP6V1C2(2), ATP6V1G3(1), ATP6V1H(1), COX10(3), COX4I2(2), COX7B(1), NDUFA2(1), NDUFA6(4), NDUFA9(1), NDUFS1(1), NDUFS2(3), NDUFS4(1), NDUFS7(1), NDUFV2(4), PPA2(4), SDHA(6), SDHC(1), TCIRG1(2), UQCRC1(1), UQCRH(2)	4188997	57	19	43	81	18	16	1	19	3	0	1.000	1.000	1.000
186	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CSF1(2), CSF2(1), HLA-DRA(2), HLA-DRB1(46), IFNA1(2), IL11(1), IL12B(2), IL1A(2), IL3(3), IL6(2), LTA(5), TGFB2(1), TNF(3)	1000891	72	19	52	43	12	28	3	26	3	0	0.979	1.000	1.000
187	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1A(3), ADRA1D(2), ADRA2C(1), ADRB1(1), ADRB2(3), CHRM3(5), DRD2(1), DRD3(1), DRD5(5), HRH1(1), HRH2(1), HTR1B(2), HTR1F(3), HTR2A(2), HTR2C(1), HTR4(1), HTR5A(1), HTR7(1)	1909000	35	19	32	47	5	8	4	17	1	0	1.000	1.000	1.000
188	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	16	CHUK(1), CREBBP(7), EP300(5), IKBKB(2), NFKB1(3), NFKBIA(3), TNF(3), TNFRSF1B(3), TRAF6(1)	1696262	28	19	25	19	4	8	0	8	8	0	0.992	1.000	1.000
189	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	15	CCND1(1), CDKN1A(4), CDKN1B(1), CDKN2A(1), E2F1(2), E2F2(3), PRB1(9), TP53(6)	608381	27	19	20	15	5	11	1	5	5	0	0.854	1.000	1.000
190	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	33	GORASP1(1), MAP2K4(1), MAPK11(1), MAPK8(1), MAPK8IP1(2), MAPK8IP3(2), MAPKAPK5(2), NFKB1(3), NFKB2(3), NFKBIA(3), NFKBIB(1), NFKBIE(6), PIK3CA(2), PIK3CD(1), TRAF3(4), TRAF6(1)	2674923	34	19	31	29	7	11	3	5	8	0	1.000	1.000	1.000
191	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(2), DLG4(1), EPHB2(1), F2(1), F2RL2(1), F2RL3(1), MAPK7(1), MAPK8(1), PLD1(4), PLD2(13), PTK2(2), RAF1(4), RASAL1(4), TEC(2), VAV1(3)	2044240	41	19	30	30	8	12	4	9	8	0	0.993	1.000	1.000
192	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	35	AKT2(1), ARHGEF11(4), BCL2(1), DLG4(1), GNA13(2), LPA(10), MAP2K4(1), MAP3K1(7), MAP3K5(1), MAPK8(1), NFKB1(3), NFKB2(3), NFKBIA(3), NFKBIB(1), NFKBIE(6), PI3(6), PLD1(4), PLD2(13), PTK2(2), ROCK2(2)	3770778	72	19	54	51	17	13	7	22	13	0	1.000	1.000	1.000
193	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	18	IFNGR2(2), IKBKB(2), JAK2(2), NFKB1(3), NFKBIA(3), RB1(1), TNF(3), TNFRSF1B(3), TP53(6), USH1C(1)	1412787	26	19	23	27	4	7	0	7	8	0	1.000	1.000	1.000
194	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	CSNK2A1(4), GRB2(1), JAK2(2), MAP2K1(2), PIK3CA(2), PLCG1(3), RAF1(4), RASA1(2), SOS1(1), STAT1(1), STAT3(8)	2194838	30	19	28	28	1	14	4	7	4	0	1.000	1.000	1.000
195	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(4), ARSB(5), ARSD(19), ARSE(1), CYP11B1(3), CYP11B2(5), HSD3B1(2), HSD3B2(2), UGT1A1(2), UGT1A10(1), UGT1A3(4), UGT1A4(1), UGT1A6(7), UGT1A7(6), UGT1A9(3), UGT2B15(3), UGT2B4(2)	1966703	70	18	46	66	14	20	3	31	2	0	1.000	1.000	1.000
196	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	13	CHUK(1), IKBKAP(11), IKBKB(2), MAP3K1(7), NFKB1(3), NFKBIA(3), TNFAIP3(8), TRAF3(4), TRAF6(1)	1392952	40	18	32	24	7	15	0	7	11	0	0.995	1.000	1.000
197	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	BCAR1(2), CXCR4(4), GNGT1(1), MAP2K1(2), NFKB1(3), PIK3C2G(10), PIK3CA(2), PLCG1(3), PTK2(2), PTK2B(4), RAF1(4)	2083046	37	18	31	47	9	11	3	8	6	0	1.000	1.000	1.000
198	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	ALDOB(1), ALDOC(1), FBP2(2), FPGT(1), FUK(3), GMPPB(2), HK1(1), HK2(4), HK3(1), HSD3B7(2), KHK(3), MTMR1(3), MTMR2(4), PFKM(1), PHPT1(1), PMM2(1), RDH12(3), SORD(5)	2779768	39	18	30	76	15	9	0	13	2	0	1.000	1.000	1.000
199	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH4(4), ADH7(2), ADHFE1(1), AGPAT1(1), AGPAT2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), CEL(4), DAK(2), DGAT1(1), DGKA(1), DGKB(2), DGKD(1), DGKE(1), DGKG(2), DGKH(2), DGKI(5), DGKQ(1), DGKZ(4), GLB1(1), GPAM(5), LCT(3), LIPA(3), LIPC(3), LIPF(2), LIPG(4), LPL(1), PNLIPRP1(4), PNPLA3(5), PPAP2B(1)	4395822	81	18	64	107	9	32	4	28	8	0	1.000	1.000	1.000
200	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(2), ACACB(12), ACAT1(2), ACAT2(1), ACOT12(3), ACSS1(2), ACSS2(1), ACYP1(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), DLAT(1), GLO1(2), GRHPR(4), LDHA(1), LDHAL6A(2), LDHAL6B(7), MDH2(5), ME2(2), ME3(2), PC(1), PCK1(3), PCK2(1), PDHA2(2)	3395782	71	18	57	91	21	27	3	17	3	0	1.000	1.000	1.000
201	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAD(2), ALAS2(1), BLVRA(1), COX10(3), CP(1), CPOX(1), EPRS(2), GUSB(1), HMOX1(3), MMAB(5), PPOX(2), UGT1A1(2), UGT1A10(1), UGT1A3(4), UGT1A4(1), UGT1A6(7), UGT1A7(6), UGT1A9(3), UGT2A1(9), UGT2B11(9), UGT2B15(3), UGT2B17(2), UGT2B28(8), UGT2B4(2), UGT2B7(4), UROS(1)	2938763	84	18	58	79	12	26	2	39	5	0	1.000	1.000	1.000
202	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(4), IL22RA1(2), IL22RA2(2), JAK1(2), JAK2(2), JAK3(2), SOCS3(1), STAT1(1), STAT3(8), TYK2(3)	1400196	27	18	26	30	5	5	4	11	2	0	1.000	1.000	1.000
203	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	BCL2(1), CREBBP(7), EP300(5), IL7R(7), JAK1(2), JAK3(2), NMI(1), PIK3CA(2), PTK2B(4)	2069090	31	18	25	38	7	12	0	6	6	0	1.000	1.000	1.000
204	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	ATM(8), CCND2(2), CDKN1B(1), EGR1(1), ESR2(1), FSHR(5), GJA4(5), INHA(4), LHCGR(3), MLH1(5), MSH5(4), NCOR1(5), NRIP1(3), PGR(7), PRLR(2), VDR(2), ZP2(3)	2543618	61	18	46	46	4	38	1	17	1	0	0.998	1.000	1.000
205	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(3), ALOX12(3), ALOX15(2), CBR3(4), CYP4F2(4), CYP4F3(1), EPX(3), GGT1(6), LPO(2), LTA4H(2), PLA2G3(4), PLA2G4A(1), PLA2G5(1), PTGES2(2), PTGIS(1), PTGS1(3), PTGS2(1), TBXAS1(5), TPO(10)	2096266	58	18	46	61	15	16	4	22	1	0	1.000	1.000	1.000
206	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ARHGAP4(2), ARHGAP5(2), ARHGAP6(2), ARHGEF1(1), ARHGEF11(4), ARHGEF5(8), ARPC1B(3), BAIAP2(4), GSN(4), LIMK1(1), MYLK(8), PFN1(3), PIP5K1A(1), PIP5K1B(1), PPP1R12B(1), TLN1(6)	3532824	51	18	37	27	9	12	7	14	9	0	0.894	1.000	1.000
207	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(4), ASAH1(4), CERK(2), CXCL2(1), EPHB2(1), ITPKA(1), ITPKB(10), MAP2K4(1), MAPK8(1), MAPK8IP1(2), MAPK8IP3(2)	2114383	29	18	23	32	5	13	2	6	3	0	1.000	1.000	1.000
208	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	25	ATF1(1), CASP2(1), CHUK(1), IKBKB(2), LTA(5), MAP2K3(4), MAP2K4(1), MAP3K1(7), MAPK8(1), NFKB1(3), NFKBIA(3), TANK(2), TNF(3)	1841230	34	18	30	24	7	9	3	6	9	0	0.992	1.000	1.000
209	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	ACAT1(2), ACAT2(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), AOC2(2), AOC3(4), AOX1(4), CYP1A1(2), CYP1A2(2), CYP2A13(5), CYP2A6(6), CYP2A7(8), CYP2B6(6), CYP2C18(2), CYP2C19(2), CYP2C8(7), CYP2C9(5), CYP2D6(11), CYP2E1(1), CYP2F1(9), CYP2J2(1), CYP3A4(1), CYP3A5(3), CYP3A7(1), CYP4B1(4), DDC(3), ECHS1(1), EHHADH(3), HAAO(1), KYNU(1), TDO2(1), WARS2(1)	4022322	114	18	91	78	31	37	2	31	13	0	1.000	1.000	1.000
210	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	ARNT(1), EIF2B3(2), EIF2B4(2), EIF2B5(4), EIF2S2(1), EIF2S3(2), ELAVL1(1), FLT1(2), FLT4(5), KDR(8), PIK3CA(2), PLCG1(3), PTK2(2)	2546146	35	18	30	40	5	13	3	14	0	0	1.000	1.000	1.000
211	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	16	ABL1(3), CDKN2A(1), E2F1(2), MYC(7), PIK3CA(2), POLR1A(3), POLR1B(2), RAC1(1), RB1(1), TP53(6)	1470999	28	17	28	36	8	8	2	6	4	0	1.000	1.000	1.000
212	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(4), AGTR1(2), EGFR(4), ELK1(1), GRB2(1), MAP2K1(2), MAP2K4(1), MAP3K1(7), MAPK8(1), MEF2B(3), MEF2C(1), PTK2(2), PTK2B(4), RAC1(1), RAF1(4), SOS1(1)	2511670	39	17	33	58	9	13	3	8	6	0	1.000	1.000	1.000
213	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCL11(1), CCR3(1), GNAS(1), GNGT1(1), LIMK1(1), MAP2K1(2), PIK3C2G(10), PLCB1(8), PPP1R12B(1), PTK2(2), RAF1(4), ROCK2(2)	1878938	34	17	29	28	9	7	1	10	7	0	1.000	1.000	1.000
214	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	MAP2K1(2), MYC(7), NFKB1(3), NFKBIA(3), PLCB1(8), RAF1(4), TNF(3)	1124288	30	17	27	28	2	8	2	8	10	0	1.000	1.000	1.000
215	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	13	C1S(4), C3(5), C4A(6), C4B(2), C5(6), C6(3), C7(7), C8A(9), C9(2)	2264301	44	17	34	32	8	18	0	17	1	0	0.997	1.000	1.000
216	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	15	C1S(4), C3(5), C4A(6), C4B(2), C5(6), C6(3), C7(7), C8A(9), C8B(3), C9(2), MASP1(1)	2500893	48	17	37	32	8	21	0	18	1	0	0.993	1.000	1.000
217	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(2), GSN(4), ITGA1(3), MAP2K1(2), MYLK(8), PFN1(3), PIK3CA(2), PTK2(2), RAF1(4), TLN1(6)	2752225	36	17	31	32	7	10	3	11	5	0	1.000	1.000	1.000
218	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOB(1), ALDOC(1), DLAT(1), ENO1(1), ENO3(2), FBP2(2), GOT2(4), HK1(1), HK2(4), HK3(1), LDHA(1), LDHAL6B(7), MDH2(5), PC(1), PCK1(3), PDHA2(2), PDHX(3), PFKM(1), PGAM2(1), PGK2(1)	3067490	43	17	32	82	10	19	2	9	3	0	1.000	1.000	1.000
219	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(4), CALCR(5), CALCRL(2), CD97(2), CRHR1(1), ELTD1(7), EMR1(17), EMR2(4), GHRHR(2), GIPR(1), GLP1R(3), GLP2R(3), LPHN1(1), LPHN2(3), LPHN3(1), SCTR(1), VIPR2(1)	2053320	58	17	42	35	13	20	5	18	2	0	0.970	1.000	1.000
220	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(2), ACSS2(1), ACYP1(1), ADH4(4), ADH7(2), ADHFE1(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH3B2(3), ALDH7A1(1), ALDH9A1(3), ALDOB(1), ALDOC(1), DLAT(1), ENO1(1), ENO3(2), FBP2(2), G6PC2(6), GALM(2), HK1(1), HK2(4), HK3(1), LDHA(1), LDHAL6A(2), LDHAL6B(7), PDHA2(2), PFKM(1), PGAM2(1), PGAM4(1), PGK2(1), PGM1(4), PGM3(1)	4254169	71	17	54	106	15	26	2	22	6	0	1.000	1.000	1.000
221	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	GUSB(1), UGT1A1(2), UGT1A10(1), UGT1A3(4), UGT1A4(1), UGT1A6(7), UGT1A7(6), UGT1A9(3), UGT2A1(9), UGT2B11(9), UGT2B15(3), UGT2B17(2), UGT2B28(8), UGT2B4(2), UGT2B7(4), XYLB(3)	1851875	65	17	45	53	5	22	2	31	5	0	1.000	1.000	1.000
222	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(3), ACAA2(3), ACADL(3), ACADM(1), ACADS(1), ACADSB(2), ACADVL(1), ACAT1(2), ACAT2(1), ACOX1(7), ACOX3(1), ACSL3(2), ACSL5(2), ADH4(4), ADH7(2), ADHFE1(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), CPT1B(4), CPT1C(1), CPT2(5), CYP4A11(4), CYP4A22(19), ECHS1(1), EHHADH(3), HADHB(1), HSD17B4(4)	3583464	92	17	66	62	16	34	7	29	6	0	1.000	1.000	1.000
223	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(6), ALG10(1), ALG11(1), ALG12(1), ALG14(2), ALG3(1), ALG6(4), ALG8(3), ALG9(1), B4GALT2(1), B4GALT3(2), DHDDS(3), DOLPP1(1), DPAGT1(2), FUT8(4), GANAB(3), MAN1A2(1), MAN1B1(1), MAN1C1(1), MAN2A1(1), MGAT1(6), MGAT4A(2), MGAT5(1), MGAT5B(2), RFT1(1), RPN2(1), ST6GAL1(3), STT3B(1)	3152563	57	17	48	58	15	22	3	14	3	0	1.000	1.000	1.000
224	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	44	AKT2(1), BRAF(3), PDPK1(1), PIK3CA(2), PIK3CD(1), PIK3CG(3), PIK3R2(1), PIK3R3(1), PRKAA1(1), RICTOR(4), RPS6KA1(2), RPS6KA2(1), RPS6KA6(1), RPS6KB2(5), STK11(1), TSC1(4), ULK1(3), ULK2(1), ULK3(3), VEGFB(1), VEGFC(2)	4010905	42	17	36	76	11	15	1	8	7	0	1.000	1.000	1.000
225	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(2), ACE2(2), AGT(4), AGTR1(2), AGTR2(3), ANPEP(4), CMA1(1), CTSG(1), ENPEP(2), LNPEP(3), MAS1(1), MME(4), NLN(4), THOP1(1)	1540715	34	17	32	17	8	11	1	10	4	0	0.811	1.000	1.000
226	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(3), ABCC2(4), ABCG2(3), BCHE(3), CES1(12), CYP3A4(1), CYP3A5(3), UGT1A1(2), UGT1A10(1), UGT1A3(4), UGT1A4(1), UGT1A6(7), UGT1A7(6), UGT1A9(3)	1661311	53	17	36	42	10	18	1	17	7	0	1.000	1.000	1.000
227	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(5), C5(6), C6(3), C7(7), ICAM1(6), IL1A(2), IL6(2), ITGA4(5), ITGAL(1), SELP(6), SELPLG(9), TNF(3), VCAM1(1)	1800032	56	17	41	57	12	13	0	25	5	1	1.000	1.000	1.000
228	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCL4(3), CCR1(1), CCR2(3), CCR3(1), CSF2(1), CXCR4(4), IFNGR2(2), IL12B(2), IL12RB1(8), IL12RB2(2), IL18R1(1), IL4R(15), TGFB2(1)	1470755	44	17	30	43	8	14	8	13	1	0	1.000	1.000	1.000
229	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(3), ATP6V0A1(2), ATP6V0A4(1), ATP6V0B(1), ATP6V1A(1), ATP6V1B1(2), ATP6V1C2(2), ATP6V1G3(1), ATP6V1H(1), ATP7A(1), ATP7B(1), COX10(3), COX7B(1), NDUFS1(1), NDUFS2(3), NDUFV2(4), PPA2(4), SDHA(6), SHMT1(3), UQCRC1(1), UQCRH(2)	2813214	44	17	34	64	11	12	1	19	1	0	1.000	1.000	1.000
230	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	19	ABCB1(6), ATM(8), CDKN1A(4), CPB2(2), CSNK1A1(2), IGFBP3(1), MAPK8(1), NFKBIB(1), NQO1(4), TP53(6)	1594294	35	17	28	21	5	19	1	6	4	0	0.920	1.000	1.000
231	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	16	ATM(8), BCL2(1), CCND1(1), CDKN1A(4), E2F1(2), RB1(1), TP53(6)	1324334	23	17	20	22	5	10	0	3	5	0	0.998	1.000	1.000
232	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(2), ACAT1(2), ACAT2(1), ACYP1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), DLAT(1), GLO1(2), GRHPR(4), LDHA(1), MDH2(5), ME2(2), ME3(2), PC(1), PCK1(3), PDHA2(2)	2693336	43	17	38	65	8	17	2	14	2	0	1.000	1.000	1.000
233	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	27	AKT2(1), BCL2(1), GRB2(1), IL4R(15), IRS1(2), IRS2(2), JAK1(2), JAK3(2), MAP4K1(1), PIK3CA(2), PIK3CD(1), RAF1(4), SOCS1(9), SOS1(1), SOS2(1), STAT6(4)	2709873	49	17	41	60	8	24	6	6	5	0	1.000	1.000	1.000
234	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	ADRB1(1), APC(4), ASAH1(4), DLG4(1), EPHB2(1), ITPR1(4), ITPR2(3), ITPR3(2), KCNJ3(1), KCNJ5(1), KCNJ9(2), PITX2(1), PTX3(3), RAC1(1), RYR1(4)	3412968	33	17	29	108	8	10	3	10	2	0	1.000	1.000	1.000
235	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ADH4(4), ADH7(2), ADHFE1(1), ALDH1A3(3), ALDH3A1(1), ALDH3B2(3), AOC2(2), AOC3(4), AOX1(4), DBH(7), DCT(1), DDC(3), FAH(1), GOT2(4), GSTZ1(3), HGD(1), TAT(2), TH(3), TPO(10), TYR(9)	2336738	68	17	50	65	25	22	1	16	4	0	1.000	1.000	1.000
236	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(2), AGT(4), AGTR1(2), AGTR2(3), CMA1(1), COL4A1(3), COL4A2(5), COL4A3(12), COL4A4(11), COL4A5(1)	1880144	44	16	35	38	11	12	1	15	5	0	0.999	1.000	1.000
237	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(4), ELK1(1), EPOR(1), GRB2(1), JAK2(2), MAP2K1(2), MAPK8(1), PLCG1(3), PTPN6(4), RAF1(4), SOS1(1)	1616140	24	16	23	17	2	10	4	4	4	0	0.971	1.000	1.000
238	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH4(4), ADH7(2), ADHFE1(1), AGPAT1(1), AGPAT2(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), CEL(4), DGAT1(1), DGKA(1), DGKB(2), DGKD(1), DGKE(1), DGKG(2), DGKH(2), DGKQ(1), DGKZ(4), GLB1(1), LCT(3), LIPC(3), LIPF(2), LIPG(4), LPL(1), PNLIPRP1(4), PPAP2B(1)	3629870	61	16	49	91	10	24	4	16	7	0	1.000	1.000	1.000
239	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS2(3), ACY3(1), ADSS(1), ADSSL1(3), AGXT(1), AGXT2(4), ASS1(1), CAD(1), DARS2(1), DDO(1), DLAT(1), GAD1(2), GAD2(1), GOT2(4), GPT(1), NARS2(1), PC(1), PDHA2(2)	2795367	30	16	26	49	10	6	2	12	0	0	1.000	1.000	1.000
240	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AASDHPPT(2), AASS(2), ACAT1(2), ACAT2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), DOT1L(2), ECHS1(1), EHHADH(3), EHMT1(1), EHMT2(2), HSD17B4(4), HSD3B7(2), NSD1(6), OGDH(2), OGDHL(3), PIPOX(1), PLOD1(2), PLOD2(2), RDH12(3), SETD1A(1), SHMT1(3), SHMT2(1), SPCS1(1), SUV39H1(1), SUV39H2(1)	4262125	63	16	56	79	15	26	2	17	3	0	1.000	1.000	1.000
241	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT2(3), COASY(4), DPYD(9), DPYS(1), ENPP1(3), ENPP3(3), PANK1(1), PANK2(1), PANK4(5), VNN1(9)	1282087	39	16	28	19	4	15	5	13	2	0	0.805	1.000	1.000
242	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(2), ARSB(5), FUCA1(2), FUCA2(8), GALNS(2), GBA(2), GLB1(1), GUSB(1), HEXB(5), HGSNAT(1), HPSE(2), HPSE2(6), IDS(1), IDUA(5), LCT(3), MAN2B1(10), MAN2B2(10), MANBA(7), NAGLU(3), NEU2(3), NEU4(4)	2626601	83	16	51	66	30	28	5	18	2	0	1.000	1.000	1.000
243	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(2), CAMK2G(1), CLCA1(2), CLCA2(10), CLCA4(6), CNGA4(3), CNGB1(4), GUCA1C(8), PDE1C(5), PRKACA(1), PRKACG(2), PRKG1(3), PRKG2(1), PRKX(1)	2276287	49	16	37	73	5	26	1	11	6	0	1.000	1.000	1.000
244	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(2), BAIAP2(4), CASP1(1), CASP7(3), CASP8(3), INSR(2), ITCH(1), MAGI1(3), MAGI2(4), RERE(2), WWP2(1)	1743666	26	16	21	58	1	7	4	11	3	0	1.000	1.000	1.000
245	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(6), ADCY3(2), ADCY9(4), AK1(1), ATP6V0A1(2), ATP6V0A2(2), ATP6V0A4(1), ATP6V0B(1), ATP6V0D2(1), ATP6V1A(1), ATP6V1C2(2), ATP6V1G3(1), ATP6V1H(1), GNAS(1), PDIA4(2), PLCG1(3), PLCG2(5), SEC61A1(1), SEC61A2(1), TRIM23(1)	2726736	39	16	35	57	11	12	4	7	5	0	1.000	1.000	1.000
246	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(1), HMOX1(3), IL10RA(4), IL10RB(2), IL1A(2), IL6(2), JAK1(2), STAT1(1), STAT3(8), TNF(3)	895076	28	16	25	26	4	9	3	10	2	0	0.999	1.000	1.000
247	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	CS(5), DLAT(1), IDH3A(1), IDH3B(1), MDH2(5), OGDH(2), PC(1), PDHA2(2), PDHX(3), SDHA(6), SDHC(1), SUCLG2(1)	2087926	29	16	22	43	8	9	2	6	4	0	1.000	1.000	1.000
248	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	ELK1(1), GRB2(1), MAP2K4(1), MAP3K1(7), MAP3K5(1), MAPKAPK2(1), MAPKAPK5(2), MEF2B(3), MEF2C(1), MKNK1(1), MYC(7), PLA2G4A(1), RAC1(1), RPS6KA5(1), STAT1(1), TGFB2(1)	2755235	31	16	29	53	5	11	2	8	5	0	1.000	1.000	1.000
249	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	COASY(4), DPYD(9), DPYS(1), ENPP1(3), ENPP3(3), PANK1(1), PANK2(1), PANK4(5)	1032407	27	16	20	16	4	9	5	8	1	0	0.916	1.000	1.000
250	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	7	ATM(8), ATR(6), CDC25C(4), CHEK2(2), TP53(6)	1143073	26	16	21	10	8	11	0	4	2	1	0.696	1.000	1.000
251	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	CAD(1), CDA(2), CTPS2(1), DCK(1), DHODH(1), DPYD(9), DPYS(1), NT5C(1), NT5E(2), NT5M(1), POLD1(2), POLE(4), POLG(2), POLL(1), POLQ(15), POLR1B(2), POLR2B(1), POLR2E(1), POLRMT(4), RRM1(1), UMPS(2), UPP1(1)	4277682	56	16	47	109	10	25	3	17	1	0	1.000	1.000	1.000
252	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	CDK5R1(1), LIMK1(1), MAP3K1(7), MYLK(8), NCF2(2), PIK3CA(2), PLD1(4), PPP1R12B(1), RAC1(1), RALBP1(1), TRIO(3), VAV1(3), WASF1(1)	2554515	35	16	29	32	9	8	4	11	3	0	1.000	1.000	1.000
253	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	BCR(1), ELK1(1), GRB2(1), LYN(2), MAP2K1(2), MAP3K1(7), MAPK8IP3(2), PAPPA(4), RAC1(1), RPS6KA1(2), SOS1(1), VAV1(3), VAV2(3), VAV3(4)	2369020	34	16	29	63	8	13	1	9	3	0	1.000	1.000	1.000
254	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT2(1), CISH(1), GRB2(1), IARS(2), IL13RA1(1), IL4R(15), JAK1(2), JAK2(2), JAK3(2), PI3(6), PIK3CA(2), SOS1(1), SOS2(1), STAT6(4), TYK2(3)	2707386	44	16	33	41	10	14	6	13	1	0	1.000	1.000	1.000
255	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	CISH(1), IL6(2), IL6R(2), JAK1(2), JAK2(2), JAK3(2), PTPRU(4), STAT3(8)	1138001	23	16	21	17	5	6	1	10	1	0	0.989	1.000	1.000
256	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	31	AKT2(1), ANKRD6(3), APC(4), AXIN2(4), CER1(4), CSNK1A1(2), DACT1(7), DKK2(2), DVL1(1), LRP1(6), MVP(2), NKD2(2), PSEN1(1), PTPRA(2), SENP2(1)	3007405	42	16	33	55	14	18	0	8	2	0	1.000	1.000	1.000
257	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD86(1), HLA-DRA(2), HLA-DRB1(46), IFNGR2(2), IL12B(2), IL12RB1(8), IL12RB2(2), IL18R1(1), IL2RA(1), IL4R(15)	915108	80	16	54	48	10	31	8	27	4	0	0.995	1.000	1.000
258	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ACADL(3), ACADM(1), ACADSB(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), AOC2(2), AOC3(4), CNDP1(8), DPYD(9), DPYS(1), ECHS1(1), EHHADH(3), GAD1(2), GAD2(1)	2109652	51	15	42	40	10	22	1	14	4	0	1.000	1.000	1.000
259	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	21	F10(1), F11(1), F12(1), F13B(1), F2(1), F5(18), F7(3), F8(3), F9(1), FGA(2), FGB(1), FGG(1), LPA(10), PLAT(1), PLG(4), SERPINB2(4), SERPINE1(1), SERPINF2(8), VWF(11)	2649739	73	15	51	85	21	31	0	18	3	0	1.000	1.000	1.000
260	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(1), AGT(4), AGTR2(3), EDN1(3), EDNRA(1), EGF(4), EGFR(4), MYC(7), NFKB1(3), PLCG1(3)	1485033	33	15	26	40	5	10	3	13	2	0	1.000	1.000	1.000
261	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	EIF4A2(1), EIF4G1(2), EIF4G2(1), EIF4G3(2), GHR(2), IRS1(2), MKNK1(1), PABPC1(23), PDPK1(1), PIK3CA(2), PTEN(2)	2077640	39	15	33	35	10	9	1	12	7	0	1.000	1.000	1.000
262	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	BCL2(1), BCR(1), GRB2(1), JAK2(2), MAP2K1(2), MAP2K4(1), MAP3K1(7), MAPK8(1), MYC(7), PIK3CA(2), RAF1(4), SOS1(1), STAT1(1)	2025614	31	15	30	46	3	14	4	8	2	0	1.000	1.000	1.000
263	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ADH4(4), ADH7(2), ADHFE1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH3B2(3), ALDH9A1(3), ALDOB(1), ALDOC(1), DLAT(1), ENO1(1), ENO3(2), FBP2(2), HK1(1), HK2(4), HK3(1), LDHA(1), PDHA2(2), PFKM(1), PGM1(4), PGM3(1)	3563180	48	15	41	89	10	21	2	11	4	0	1.000	1.000	1.000
264	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	31	ANPEP(4), G6PD(1), GGT1(6), GPX5(1), GSTA2(7), GSTA3(2), GSTA4(1), GSTM3(3), GSTM5(1), GSTO2(2), GSTP1(1), GSTT2(2), GSTZ1(3), IDH1(1), PGD(1)	1402190	36	15	23	28	6	17	2	9	1	1	0.993	1.000	1.000
265	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	AGXT(1), AGXT2(4), ALAS2(1), AMT(1), AOC2(2), AOC3(4), BHMT(1), CBS(2), CHKA(1), CPT1B(4), CTH(2), DAO(2), DMGDH(4), GAMT(1), GARS(1), GCAT(3), PEMT(4), PLCG1(3), PLCG2(5), PSPH(13), SARDH(2), SARS(1), SHMT1(3), SHMT2(1)	3139026	66	15	49	86	22	24	3	15	2	0	1.000	1.000	1.000
266	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ADH4(4), ADH7(2), ADHFE1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH3B2(3), ALDH9A1(3), ALDOB(1), ALDOC(1), DLAT(1), ENO1(1), ENO3(2), FBP2(2), HK1(1), HK2(4), HK3(1), LDHA(1), PDHA2(2), PFKM(1), PGM1(4), PGM3(1)	3563180	48	15	41	89	10	21	2	11	4	0	1.000	1.000	1.000
267	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	30	CABIN1(4), CAMK1G(1), INSR(2), MAPK7(1), MEF2B(3), MEF2C(1), NFATC1(6), NFATC2(2), PIK3CA(2), PPP3CA(1), PPP3CC(1)	2582756	24	15	21	54	7	6	0	8	3	0	1.000	1.000	1.000
268	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(2), CLYBL(4), CS(5), IDH1(1), IDH3A(1), IDH3B(1), MDH2(5), OGDH(2), OGDHL(3), PC(1), PCK1(3), PCK2(1), SDHA(6), SDHC(1), SUCLG2(1)	2163943	37	15	28	51	8	12	1	11	5	0	1.000	1.000	1.000
269	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOB(1), ALDOC(1), DERA(1), FBP2(2), G6PD(1), H6PD(3), PFKM(1), PGD(1), PGM1(4), PGM3(1), PRPS1L1(2), TKT(1), TKTL2(2)	1789884	21	15	18	51	6	10	1	4	0	0	1.000	1.000	1.000
270	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(2), CYP2A13(5), CYP2A6(6), CYP2A7(8), NAT1(1), NAT2(7), XDH(6)	583688	35	15	23	25	5	16	2	7	5	0	0.968	1.000	1.000
271	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	AGXT(1), AGXT2(4), ALAS2(1), AMT(1), AOC2(2), AOC3(4), BHMT(1), CBS(2), CHKA(1), CTH(2), DAO(2), DMGDH(4), GAMT(1), GARS(1), GCAT(3), HSD3B7(2), PEMT(4), PIPOX(1), PSPH(13), RDH12(3), SARDH(2), SARS(1), SHMT1(3), SHMT2(1)	3194363	60	15	43	80	24	23	1	11	1	0	1.000	1.000	1.000
272	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ACAA1(3), ACAA2(3), ACADM(1), ACADS(1), ACAT1(2), ACAT2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), AOX1(4), BCAT2(3), BCKDHA(1), BCKDHB(1), DBT(1), ECHS1(1), EHHADH(3), HADHB(1), HIBCH(2), HMGCS2(1), HSD17B4(4), MCCC1(6), MCCC2(1), MCEE(5), MUT(5), OXCT1(2), OXCT2(2), PCCA(1), PCCB(1)	3223373	70	15	58	51	17	24	3	19	7	0	1.000	1.000	1.000
273	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(2), ASS1(1), CKM(1), CPS1(5), DAO(2), EPRS(2), GAMT(1), GOT2(4), LAP3(1), NOS1(3), OTC(4), P4HA3(2), PARS2(2), PRODH(4), PYCRL(5), RARS(2), RARS2(5)	2729647	46	15	35	53	10	19	2	13	2	0	1.000	1.000	1.000
274	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ALDH1A3(3), ALDH3A1(1), ALDH3B2(3), AOC2(2), AOC3(4), DDC(3), EPX(3), ESCO1(1), GOT2(4), LPO(2), PNPLA3(5), TAT(2), TPO(10)	2500214	43	15	37	45	14	13	2	13	1	0	1.000	1.000	1.000
275	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	ACAT1(2), ACAT2(1), AFMID(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), AOC2(2), AOC3(4), AOX1(4), CYP1A1(2), CYP1A2(2), CYP1B1(2), DDC(3), ECHS1(1), EHHADH(3), HAAO(1), HEMK1(1), HSD17B4(4), INMT(9), KYNU(1), LCMT1(1), LCMT2(1), LNX1(1), METTL2B(3), OGDH(2), OGDHL(3), PRMT2(1), PRMT6(2), PRMT8(1), TDO2(1), WARS2(1)	4422017	74	15	65	76	19	29	3	20	3	0	1.000	1.000	1.000
276	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	CBS(2), CTH(2), GGT1(6), HEMK1(1), LCMT1(1), LCMT2(1), MAT2B(1), METTL2B(3), PAPSS1(5), PAPSS2(1), PRMT2(1), PRMT6(2), PRMT8(1), SCLY(3)	1834106	30	15	21	25	7	12	0	8	3	0	0.994	1.000	1.000
277	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(1), AADAC(2), ACADS(1), ACAT1(2), ACAT2(1), ACSM1(3), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH5A1(3), ALDH7A1(1), ALDH9A1(3), BDH1(1), BDH2(2), DDHD1(1), ECHS1(1), EHHADH(3), GAD1(2), GAD2(1), HMGCS2(1), HSD17B4(4), HSD3B7(2), L2HGDH(1), OXCT1(2), OXCT2(2), PDHA2(2), PLA1A(2), RDH12(3)	3021343	57	15	49	62	11	23	3	14	6	0	1.000	1.000	1.000
278	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	A4GALT(3), B3GALNT1(3), B3GALT5(1), B3GNT1(1), B3GNT3(1), B3GNT4(2), B3GNT5(2), B4GALNT1(3), B4GALT2(1), B4GALT3(2), B4GALT4(1), FUT1(1), FUT2(1), FUT3(6), FUT4(1), FUT5(6), FUT6(7), GBGT1(4), PIGB(4), PIGC(3), PIGF(1), PIGG(7), PIGK(1), PIGL(1), PIGM(2), PIGN(3), PIGP(2), PIGQ(4), PIGS(1), PIGZ(3), ST3GAL4(3), ST3GAL5(3), ST3GAL6(1), ST6GALNAC3(1)	3632832	86	15	61	103	16	38	3	22	7	0	1.000	1.000	1.000
279	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(3), GRB2(1), IL3(3), IL3RA(4), JAK2(2), MAP2K1(2), PTPN6(4), RAF1(4), SOS1(1)	1314470	24	15	19	18	3	9	1	9	2	0	0.987	1.000	1.000
280	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(3), COL4A2(5), COL4A3(12), COL4A4(11), COL4A5(1), F10(1), F11(1), F12(1), F2(1), F2R(1), F5(18), F8(3), F9(1), FGA(2), FGB(1), FGG(1), KLKB1(4), PROC(2), PROS1(1), SERPINC1(1), SERPING1(1)	3290647	72	15	54	84	18	31	1	19	3	0	1.000	1.000	1.000
281	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	CSNK2A1(4), DPM2(1), ELK1(1), GRB2(1), KLK2(1), MAP2K1(2), MAPK8(1), NGFR(2), PIK3CA(2), PLCG1(3), RAF1(4), SOS1(1)	1403096	23	15	22	19	2	10	5	2	4	0	0.989	1.000	1.000
282	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(2), GRB2(1), MAP2K1(2), MAP2K3(4), MAP2K4(1), MAP3K1(7), MAPK8(1), PLCG1(3), PTK2B(4), RAC1(1), RAF1(4), SOS1(1)	2100377	31	15	27	48	6	11	6	2	6	0	1.000	1.000	1.000
283	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	ATF1(1), EEF2K(3), ELK1(1), IL1R1(1), MAP2K3(4), MAP2K4(1), MAP3K10(1), MAP3K4(1), MAP3K5(1), MAPK11(1), MAPKAPK2(1), MAPKAPK5(2), MKNK1(1), MKNK2(3), NFKB1(3), TRAF6(1)	2532189	26	15	25	34	8	5	2	4	7	0	1.000	1.000	1.000
284	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	AKT2(1), BTK(2), CDKN2A(1), GRB2(1), IARS(2), IGFBP1(2), PIK3CA(2), PTEN(2), RPS6KA1(2), RPS6KA2(1), SFN(2), SOS1(1), SOS2(1), TEC(2), YWHAE(1)	2627883	23	15	19	45	1	9	2	5	6	0	1.000	1.000	1.000
285	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2G(1), ITPKA(1), ITPKB(10), ITPR1(4), ITPR2(3), ITPR3(2), NFAT5(1), PDE6A(1), PDE6C(1), PDE6H(1), SLC6A13(2), TF(2)	2666040	29	15	26	102	9	9	0	6	5	0	1.000	1.000	1.000
286	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(3), ACAA2(3), ACADL(3), ACADM(1), ACADS(1), ACADSB(2), ACAT1(2), ACAT2(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), AOX1(4), BCKDHA(1), BCKDHB(1), ECHS1(1), EHHADH(3), HADHB(1), MCCC1(6), MCCC2(1), MCEE(5), MUT(5), OXCT1(2), PCCA(1), PCCB(1)	2666035	62	15	51	46	16	22	1	16	7	0	1.000	1.000	1.000
287	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CHUK(1), EGR2(1), MAP3K1(7), MYC(7), NFATC1(6), NFATC2(2), NFKB1(3), NFKBIA(3), PLCG1(3), PPP3CA(1), PPP3CC(1), PRKACG(2), VIPR2(1)	2047935	38	15	32	48	6	11	3	13	5	0	1.000	1.000	1.000
288	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	CHUK(1), IKBKB(2), MAP3K1(7), MAP3K5(1), MAP4K5(3), MAPK8(1), NFKB1(3), NFKBIA(3), TNFSF9(1)	1462264	22	14	20	22	4	7	1	5	5	0	1.000	1.000	1.000
289	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	ACVR1(1), APC(4), BMP10(3), BMP2(2), BMP4(2), BMP5(1), BMP7(1), BMPR1A(3), CHRD(4), DVL1(1), FZD1(1), GATA4(2), MEF2C(1), NKX2-5(1), NPPA(1), TGFB2(1), TGFBR3(2)	2695065	31	14	27	53	9	10	3	9	0	0	1.000	1.000	1.000
290	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(2), CR1(18), CR2(7), FCGR2B(1), HLA-DRA(2), HLA-DRB1(46), ICAM1(6), ITGAL(1), PTPRC(1)	1233667	84	14	54	39	7	37	3	31	6	0	0.888	1.000	1.000
291	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(1), ACADS(1), ACAT1(2), ACAT2(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH5A1(3), ALDH9A1(3), ECHS1(1), EHHADH(3), GAD1(2), GAD2(1), L2HGDH(1), OXCT1(2), PDHA2(2)	1892140	34	14	31	41	6	14	2	9	3	0	1.000	1.000	1.000
292	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD3D(1), CD3G(2), CD80(2), CD86(1), CTLA4(1), GRB2(1), HLA-DRA(2), HLA-DRB1(46), PIK3CA(2)	923199	58	14	44	30	5	25	1	23	4	0	0.965	1.000	1.000
293	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNA1(2), IL12B(2), IL16(4), IL1A(2), IL3(3), IL6(2), IL9(1), LTA(5), TNF(3)	716613	24	14	18	20	8	10	0	5	1	0	0.991	1.000	1.000
294	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	BCL2(1), BIRC2(1), CASP10(2), CASP7(3), CASP8(3), CASP9(4), CHUK(1), DFFA(1), LMNA(3), NFKB1(3), NFKBIA(3), SPTAN1(1), TNFRSF10A(7), TNFRSF10B(4)	2478464	37	14	27	48	6	15	1	9	6	0	1.000	1.000	1.000
295	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(5), CDT1(2), GMNN(1), MCM10(7), MCM3(2), MCM4(2), MCM5(3), MCM7(2), NACA(7), POLA2(1), POLD1(2), POLD3(1), POLD4(1), POLE(4), PRIM1(1), RFC4(2), RFC5(1), RPA4(2), UBB(1)	3749026	47	14	32	86	8	20	1	16	2	0	1.000	1.000	1.000
296	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(3), ALOX15(2), ALOX15B(6), GGT1(6), LTA4H(2), PTGIS(1), PTGS1(3), PTGS2(1), TBXAS1(5)	1168123	29	14	23	35	7	5	3	11	3	0	1.000	1.000	1.000
297	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ALDH4A1(2), ALDH5A1(3), CAD(1), CPS1(5), EPRS(2), GAD1(2), GAD2(1), GFPT1(1), GLS(1), GLS2(2), GMPS(1), GOT2(4), GPT(1), NADSYN1(1), QARS(1)	2439238	28	14	21	47	5	7	2	11	3	0	1.000	1.000	1.000
298	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	DHCR7(1), FDFT1(2), GGCX(2), GGPS1(1), HMGCR(1), HSD17B7(4), IDI2(2), LSS(3), MVK(2), NQO1(4), NSDHL(1), SQLE(1), TM7SF2(3)	1442027	27	14	21	46	7	12	2	3	3	0	1.000	1.000	1.000
299	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(3), ACAA2(3), ACAD8(1), ADH4(4), ADH7(2), ADHFE1(1), AKR1C4(4), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), BAAT(4), CEL(4), CYP27A1(1), HADHB(1), HSD3B7(2), LIPA(3), RDH12(3), SLC27A5(8), SOAT1(1), SOAT2(3)	2344992	62	14	47	60	15	23	2	17	5	0	1.000	1.000	1.000
300	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ALDH4A1(2), ALDH5A1(3), CAD(1), CPS1(5), EPRS(2), GAD1(2), GAD2(1), GFPT1(1), GFPT2(2), GLS(1), GLS2(2), GMPS(1), GOT2(4), GPT(1), NADSYN1(1), QARS(1)	2892271	30	14	22	57	5	9	2	11	3	0	1.000	1.000	1.000
301	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ACADM(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), AOC2(2), AOC3(4), CNDP1(8), DPYD(9), DPYS(1), ECHS1(1), EHHADH(3), GAD1(2), GAD2(1), HIBCH(2), SRM(1)	1960112	49	14	41	36	9	21	1	14	4	0	0.999	1.000	1.000
302	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	37	ANPEP(4), G6PD(1), GGT1(6), GPX5(1), GSTA2(7), GSTA3(2), GSTA4(1), GSTM3(3), GSTM5(1), GSTO2(2), GSTP1(1), GSTT2(2), GSTZ1(3), IDH1(1), OPLAH(8)	1726611	43	14	27	31	11	16	3	11	1	1	0.993	1.000	1.000
303	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	ALOX15(2), CYP1A2(2), CYP2C18(2), CYP2C19(2), CYP2C8(7), CYP2C9(5), CYP2E1(1), CYP2J2(1), CYP3A4(1), CYP3A43(6), CYP3A5(3), CYP3A7(1), HSD3B7(2), PLA2G2D(1), PLA2G3(4), PLA2G4A(1), PLA2G5(1), RDH12(3)	1787057	45	14	36	37	16	10	1	12	6	0	1.000	1.000	1.000
304	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOB(1), ALDOC(1), FBP2(2), GOT2(4), GPT(1), MDH2(5), ME3(2), PGK2(1), TKT(1), TKTL2(2)	1482453	20	14	17	30	4	7	1	8	0	0	1.000	1.000	1.000
305	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(4), ACP2(3), ACP5(1), ACP6(1), ACPT(8), ENPP1(3), ENPP3(3), FLAD1(1), MTMR1(3), MTMR2(4), PHPT1(1), TYR(9)	1116158	41	14	25	24	12	10	2	14	3	0	0.962	1.000	1.000
306	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(5), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), CYP2C19(2), CYP2C9(5), DHRS1(2), DHRS2(2), DHRSX(1), ECHS1(1), EHHADH(3), ESCO1(1), PNPLA3(5), YOD1(1)	2253090	42	14	36	37	13	15	0	13	1	0	1.000	1.000	1.000
307	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS2(3), CARS2(5), DARS2(1), EPRS(2), FARS2(1), FARSA(2), FARSB(1), GARS(1), IARS(2), LARS(4), NARS2(1), PARS2(2), QARS(1), RARS(2), RARS2(5), SARS(1), VARS(3), VARS2(10), WARS2(1), YARS2(2)	3934887	50	14	41	79	9	26	1	10	4	0	1.000	1.000	1.000
308	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	CLOCK(2), CSNK1E(1), NPAS2(4), PER1(4), PER2(4), PER3(20)	1266817	35	14	22	27	5	13	0	16	1	0	0.999	1.000	1.000
309	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	BCL2(1), CASP9(4), FAS(5), IL1A(2), MAPKAPK2(1), TNF(3)	815402	16	14	14	26	3	7	1	2	3	0	1.000	1.000	1.000
310	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(4), ELK1(1), GRB2(1), IL2RA(1), IL2RB(2), JAK1(2), JAK3(2), MAP2K1(2), MAPK8(1), RAF1(4), SOS1(1)	1768450	21	14	20	40	4	9	2	2	4	0	1.000	1.000	1.000
311	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(4), CAPN2(4), EP300(5), HDAC2(2), NFATC1(6), NFATC2(2), PPP3CA(1), PPP3CC(1)	1783310	25	14	20	26	6	5	0	12	2	0	1.000	1.000	1.000
312	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(2), ARHGEF1(1), GNA13(2), GNGT1(1), MYLK(8), PLCB1(8), PPP1R12B(1)	1504290	23	14	19	19	3	4	2	5	9	0	0.993	1.000	1.000
313	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	ARHGEF1(1), F2(1), F2R(1), F2RL3(1), GNA13(2), GNGT1(1), PIK3CA(2), PLCB1(8), PPP1R12B(1), PTK2B(4)	1892787	22	14	18	35	2	5	0	4	11	0	1.000	1.000	1.000
314	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(7), EP300(5), PELP1(6)	1122315	18	14	14	20	1	5	0	8	4	0	1.000	1.000	1.000
315	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOB(1), ALDOC(1), FBP2(2), G6PD(1), H6PD(3), PFKM(1), PGD(1), PGM1(4), PGM3(1), PRPS1L1(2), TKT(1)	1479934	18	14	15	49	6	9	0	3	0	0	1.000	1.000	1.000
316	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ALDH1A3(3), ALDH3A1(1), ALDH3B2(3), AOC2(2), AOC3(4), DDC(3), EPX(3), GOT2(4), LPO(2), TAT(2), TPO(10)	1626548	37	14	32	39	14	11	2	9	1	0	1.000	1.000	1.000
317	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(4), CREBBP(7), DVL1(1), EP300(5), FZD1(1), PITX2(1), TRRAP(2)	2430669	21	14	20	26	5	6	1	6	3	0	1.000	1.000	1.000
318	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(7), EP300(5), LPL(1), NCOA1(2), NCOA2(1), PPARG(3)	1337157	19	14	17	12	1	7	0	7	4	0	0.984	1.000	1.000
319	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	12	ATM(8), CDC25C(4), MYT1(1), RB1(1), TP53(6)	1297749	20	14	17	19	5	9	0	3	3	0	0.996	1.000	1.000
320	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(2), CD44(3), CSF1(2), FCGR3A(15), IL6R(2), SELL(3), TGFB2(1), TNF(3), TNFRSF1B(3), TNFRSF8(6)	1024926	40	14	27	28	6	14	3	13	4	0	0.981	1.000	1.000
321	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(3), DYRK1B(1), GLI2(6), GLI3(3), PRKACG(2), SHH(1), SMO(2)	1223834	18	14	15	29	6	3	1	6	2	0	1.000	1.000	1.000
322	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(1), F2R(1), F2RL3(1), GNGT1(1), ITGA1(3), MAP2K1(2), PLA2G4A(1), PLCB1(8), PTGS1(3), PTK2(2), RAF1(4), TBXAS1(5)	1779098	32	14	29	45	7	9	1	9	6	0	1.000	1.000	1.000
323	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	CBL(1), EGF(4), EGFR(4), GRB2(1), MAP2K1(2), PTPRB(8), RAF1(4), RASA1(2), SOS1(1), SPRY2(3), SPRY3(1)	1828397	31	14	24	33	3	18	4	5	1	0	1.000	1.000	1.000
324	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(8), APOA1(1), APOA4(4), APOC2(1), CETP(5), DGAT1(1), HMGCR(1), LCAT(1), LDLR(3), LIPC(3), LPL(1), LRP1(6), SOAT1(1)	1991949	36	14	28	46	9	16	2	8	1	0	1.000	1.000	1.000
325	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(4), CDH1(1), CREBBP(7), EP300(5), MAP2K1(2), TGFB2(1)	1878924	20	14	19	15	4	6	1	6	3	0	0.993	1.000	1.000
326	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTN1(3), ACTN2(1), ITGA1(3), ITGB3(3), PTK2(2), RAC1(1), SPTAN1(1), TLN1(6)	2124621	20	14	15	31	5	4	2	6	3	0	1.000	1.000	1.000
327	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	CASP9(4), CHUK(1), GH1(2), GHR(2), NFKB1(3), NFKBIA(3), PDPK1(1), PIK3CA(2), PPP2CA(1)	1081965	19	13	16	20	1	8	1	3	6	0	0.999	1.000	1.000
328	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	AGMAT(5), ALDH1A2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH4A1(2), ALDH9A1(3), AOC2(2), AOC3(4), CKM(1), CPS1(5), DAO(2), GAMT(1), GOT2(4), NOS1(3), OTC(4), P4HA3(2), RARS(2)	3328985	51	13	40	68	16	16	0	17	2	0	1.000	1.000	1.000
329	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(3), ACAA2(3), ADH4(4), ADH7(2), ADHFE1(1), AKR1C4(4), ALDH1A2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), BAAT(4), CEL(4), CYP27A1(1), HADHB(1), SOAT2(3)	1704298	44	13	34	47	8	19	1	11	5	0	1.000	1.000	1.000
330	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOB(1), ALDOC(1), FBP2(2), GOT2(4), GPT(1), MDH2(5), ME2(2), ME3(2), TKT(1)	1330472	19	13	16	29	4	7	1	7	0	0	1.000	1.000	1.000
331	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CREBBP(7), EP300(5), NCOA3(3), PRKACG(2)	1523791	17	13	15	30	1	5	0	7	4	0	1.000	1.000	1.000
332	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCNA1(1), CCND1(1), CCND2(2), CCND3(3), CDKN1A(4), CDKN1B(1), CDKN2A(1), CDKN2B(1), E2F1(2), RB1(1)	1174635	17	13	16	21	4	4	1	4	4	0	1.000	1.000	1.000
333	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	CS(5), IDH1(1), IDH3A(1), IDH3B(1), MDH2(5), PC(1), PCK1(3), SDHA(6), SUCLG2(1)	1500331	24	13	17	40	5	9	1	5	4	0	1.000	1.000	1.000
334	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	ASAH1(4), GNGT1(1), ITGB3(3), PIK3CA(2), PLCB1(8), PTK2(2), RAC1(1), SMPD2(7), SPHK1(1)	1985882	29	13	20	46	5	7	2	8	7	0	1.000	1.000	1.000
335	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(4), EGFR(4), MAP2K1(2), MAP3K1(7), NCOR2(9), THRA(1), THRB(2)	1301855	29	13	25	26	8	14	1	4	2	0	0.999	1.000	1.000
336	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCL11(1), CCR3(1), CSF2(1), HLA-DRA(2), HLA-DRB1(46), IL3(3)	208541	54	13	38	20	6	23	1	22	2	0	0.447	1.000	1.000
337	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	ALDOB(1), ALDOC(1), FBP2(2), FPGT(1), GMPPB(2), HK1(1), HK2(4), HK3(1), KHK(3), PFKM(1), PMM2(1), SORD(5)	1774868	23	13	17	48	7	6	0	9	1	0	1.000	1.000	1.000
338	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	B4GALT2(1), FBP2(2), GAA(1), GALK2(1), GALT(2), GANAB(3), GLB1(1), HK1(1), HK2(4), HK3(1), LALBA(1), LCT(3), MGAM(12), PFKM(1), PGM1(4), PGM3(1)	2384083	39	13	33	69	6	17	1	9	6	0	1.000	1.000	1.000
339	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(2), JUNB(1), MAP2K3(4), NFATC1(6), NFATC2(2), PRKACG(2)	921502	17	13	14	25	5	3	1	7	1	0	1.000	1.000	1.000
340	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ELK1(1), GNAS(1), GNGT1(1), MAP2K1(2), NFATC1(6), NFATC2(2), NFATC3(1), NFATC4(1), PLCG1(3), PPP3CA(1), PPP3CC(1), PRKACG(2), RAF1(4)	2587317	26	13	22	49	6	8	3	8	1	0	1.000	1.000	1.000
341	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	AGMAT(5), ALDH18A1(2), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), AOC2(2), AOC3(4), ASS1(1), CPS1(5), OTC(4), SRM(1)	2171687	38	13	29	39	9	14	0	13	2	0	1.000	1.000	1.000
342	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP1(4), ACP2(3), ACP5(1), ACP6(1), ACPT(8), ALPL(2), ALPP(13), ALPPL2(5), CYP3A4(1), CYP3A43(6), CYP3A5(3), CYP3A7(1), DHRS1(2), DHRS2(2), DHRSX(1), PON1(6), PON2(3)	1357289	62	13	42	44	12	17	1	23	9	0	0.999	1.000	1.000
343	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(2), FUCA1(2), FUCA2(8), GLB1(1), HEXB(5), LCT(3), MAN2B1(10), MAN2B2(10), MANBA(7), NEU2(3), NEU4(4)	1540625	55	13	30	36	17	25	3	9	1	0	0.977	1.000	1.000
344	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B3GNT6(1), B4GALT5(1), C1GALT1C1(1), GALNT1(1), GALNT10(1), GALNT12(1), GALNT2(2), GALNT4(5), GALNT5(1), GALNT6(1), GALNT8(8), GALNT9(1), GALNTL5(5), GCNT1(4), GCNT4(2), ST6GALNAC1(3), WBSCR17(1)	2371249	39	13	29	43	6	20	1	12	0	0	1.000	1.000	1.000
345	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPLD1(5), PGAP1(2), PIGB(4), PIGC(3), PIGF(1), PIGG(7), PIGK(1), PIGL(1), PIGM(2), PIGN(3), PIGP(2), PIGQ(4), PIGS(1), PIGW(2), PIGZ(3)	1820298	41	13	32	61	4	22	2	12	1	0	1.000	1.000	1.000
346	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	B3GNT1(1), B3GNT3(1), B3GNT4(2), B3GNT5(2), B4GALT2(1), B4GALT3(2), B4GALT4(1), FUT1(1), FUT2(1), FUT3(6), FUT4(1), FUT5(6), FUT6(7), ST3GAL6(1)	1175531	33	13	24	22	13	8	1	10	1	0	0.976	1.000	1.000
347	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ACACA(2), ACACB(12), ACADM(1), ACAT1(2), ACAT2(1), ACSS1(2), ACSS2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), ECHS1(1), EHHADH(3), HIBCH(2), LDHA(1), LDHAL6A(2), LDHAL6B(7), MCEE(5), MUT(5), PCCA(1), PCCB(1), SUCLG2(1)	2888515	64	13	50	62	24	24	1	12	3	0	1.000	1.000	1.000
348	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(4), BST1(4), ENPP1(3), ENPP3(3), NADK(3), NADSYN1(1), NMNAT1(1), NMNAT2(1), NNT(2), NT5C(1), NT5C1B(2), NT5C2(1), NT5E(2), NT5M(1), NUDT12(2), QPRT(1)	1583122	32	13	24	30	7	15	2	3	5	0	1.000	1.000	1.000
349	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA2(1), POLD1(2), POLD3(1), POLD4(1), POLE(4), POLE4(2), POLG(2), POLG2(1), POLH(2), POLL(1), POLM(1), POLQ(15), PRIM1(1), REV1(8), REV3L(4), RFC5(1)	3042921	47	13	37	44	7	21	2	15	2	0	1.000	1.000	1.000
350	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	CSNK2A1(4), ELK1(1), GRB2(1), IRS1(2), MAP2K1(2), MAPK8(1), PIK3CA(2), RAF1(4), RASA1(2), SOS1(1)	1814064	20	13	19	22	2	11	2	1	4	0	1.000	1.000	1.000
351	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCL11(1), CCR3(1), HLA-DRA(2), HLA-DRB1(46), IL5RA(2), IL6(2)	380519	54	13	40	27	7	22	1	22	2	0	0.860	1.000	1.000
352	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	CSNK2A1(4), ELK1(1), GRB2(1), INSR(2), IRS1(2), MAP2K1(2), MAPK8(1), PIK3CA(2), RAF1(4), RASA1(2), SLC2A4(1), SOS1(1)	1871350	23	13	22	34	3	13	2	1	4	0	1.000	1.000	1.000
353	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AASDH(8), AASDHPPT(2), AASS(2), ACAT1(2), ACAT2(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), DOT1L(2), ECHS1(1), EHHADH(3), EHMT1(1), EHMT2(2), PLOD1(2), PLOD2(2), SHMT1(3), SHMT2(1)	2719521	46	13	39	58	11	18	0	14	3	0	1.000	1.000	1.000
354	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(4), ENPP1(3), ENPP3(3), NADSYN1(1), NMNAT1(1), NMNAT2(1), NNT(2), NT5C(1), NT5E(2), NT5M(1), QPRT(1)	1071560	20	13	15	11	3	12	1	3	1	0	0.786	1.000	1.000
355	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	GUSB(1), UCHL1(3), UGT1A1(2), UGT1A10(1), UGT1A3(4), UGT1A4(1), UGT1A6(7), UGT1A7(6), UGT1A9(3), UGT2B15(3), UGT2B4(2)	1249774	33	13	20	33	3	8	1	21	0	0	1.000	1.000	1.000
356	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	PIK3CA(2), PLCB1(8), PLCG1(3), VAV1(3)	939047	16	13	13	16	1	2	2	4	7	0	0.999	1.000	1.000
357	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(2), BLVRA(1), CP(1), CPOX(1), EPRS(2), GUSB(1), HMOX1(3), PPOX(2), UGT1A1(2), UGT1A10(1), UGT1A3(4), UGT1A4(1), UGT1A6(7), UGT1A7(6), UGT1A9(3), UGT2B15(3), UGT2B4(2), UROS(1)	1959904	43	13	29	44	6	12	1	24	0	0	1.000	1.000	1.000
358	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ACACA(2), ACADL(3), ACADM(1), ACADSB(2), ACAT1(2), ACAT2(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), ECHS1(1), EHHADH(3), LDHA(1), MCEE(5), MUT(5), PCCA(1), PCCB(1), SUCLG2(1)	2418125	43	13	36	41	12	17	0	12	2	0	1.000	1.000	1.000
359	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	CREBBP(7), DFFA(1), GZMB(5), HMGB2(1), PRF1(2)	788678	16	13	14	12	4	2	2	5	3	0	0.982	1.000	1.000
360	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	ATF1(1), BRAF(3), DUSP4(2), EEF2K(3), GRB2(1), MAP2K1(2), MKNK1(1), MKNK2(3), MOS(2), NFKB1(3), RPS6KA1(2), RPS6KA2(1), SOS1(1), SOS2(1), TRAF3(4)	2214013	30	13	27	50	6	11	2	6	5	0	1.000	1.000	1.000
361	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(2), JAK2(2), JAK3(2), STAT3(8), TYK2(3)	894433	17	13	17	19	4	3	1	8	1	0	1.000	1.000	1.000
362	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(3), LPO(2), TPO(10), TYR(9)	716695	24	13	17	15	9	5	2	8	0	0	0.960	1.000	1.000
363	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3D(1), CD3G(2), HLA-DRA(2), HLA-DRB1(46), PTPRC(1), ZAP70(1)	665273	53	13	39	28	6	21	1	22	3	0	0.932	1.000	1.000
364	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(3), COL4A2(5), COL4A3(12), COL4A4(11), COL4A5(1), SLC23A1(1), SLC2A3(1)	1889149	34	13	26	50	8	10	1	10	5	0	1.000	1.000	1.000
365	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(5), C5(6), C6(3), C7(7), C8A(9), C9(2)	926345	32	12	25	26	6	11	0	14	1	0	0.999	1.000	1.000
366	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BCL2(1), CASP8(3), MAP2K1(2), MAP2K4(1), MAP3K1(7), MAPK8(1), NFKB1(3), RAF1(4)	1497609	22	12	20	29	4	9	3	2	4	0	1.000	1.000	1.000
367	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	FHL5(5), FSHR(5), GNAS(1), XPO1(3)	704071	14	12	10	11	5	4	2	3	0	0	0.980	1.000	1.000
368	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(4), CD2(1), CD33(10), CD5(3), CSF2(1), IFNA1(2), IL12B(2), IL3(3), ITGAX(6), TLR2(2), TLR4(2), TLR7(1)	1349278	37	12	27	16	8	16	3	7	3	0	0.579	1.000	1.000
369	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(2), DDX20(9), E2F1(2), ETS1(1), ETS2(2), HDAC2(2), NCOR2(9), RBL2(3)	2019780	30	12	22	43	7	12	2	7	2	0	1.000	1.000	1.000
370	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	CS(5), GRHPR(4), HAO1(1), HYI(1), MDH2(5), MTHFD1(4)	922493	20	12	14	22	3	6	1	7	3	0	1.000	1.000	1.000
371	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(7), GABBR1(1), GPRC5C(2), GRM1(2), GRM2(1), GRM4(1), GRM5(1), GRM7(1), GRM8(6)	1515042	22	12	17	36	4	5	2	11	0	0	1.000	1.000	1.000
372	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	MAP2K1(2), MAP2K3(4), MAP3K1(7), NFKB1(3), PIK3CA(2), RB1(1), SP1(1)	1441506	20	12	18	28	4	7	2	2	5	0	1.000	1.000	1.000
373	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	B4GALT2(1), G6PC2(6), GAA(1), GALK2(1), GALT(2), GANC(5), GLB1(1), HK1(1), HK2(4), HK3(1), HSD3B7(2), LALBA(1), LCT(3), MGAM(12), PFKM(1), PGM1(4), PGM3(1), RDH12(3)	2828641	50	12	38	78	9	18	3	14	6	0	1.000	1.000	1.000
374	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ACY3(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH3B2(3), ALDH7A1(1), ALDH9A1(3), AOC2(2), AOC3(4), CNDP1(8), DDC(3), FTCD(1), HDC(4), HEMK1(1), HNMT(1), LCMT1(1), LCMT2(1), METTL2B(3), PRMT2(1), PRMT6(2), PRMT8(1)	2933698	51	12	42	56	16	19	1	10	5	0	1.000	1.000	1.000
375	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(1), B3GNT7(2), B4GALT2(1), B4GALT3(2), B4GALT4(1), CHST2(1), CHST4(2), CHST6(1), FUT8(4), ST3GAL4(3)	890903	18	12	14	21	5	3	0	6	4	0	1.000	1.000	1.000
376	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(1), EXT2(1), EXTL1(2), EXTL3(1), HS3ST1(1), HS3ST3B1(1), HS3ST5(1), HS6ST1(3), HS6ST2(1), HS6ST3(2), NDST1(1), NDST3(1)	1549052	16	12	15	44	2	4	1	7	2	0	1.000	1.000	1.000
377	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSA(4), ARSD(19), ARSE(1), ASAH1(4), CERK(2), DEGS1(1), DEGS2(4), ENPP7(4), GAL3ST1(4), GALC(3), GBA(2), GLB1(1), LCT(3), NEU2(3), NEU4(4), PPAP2B(1), SGPP1(1), SMPD2(7), SMPD4(2), SPHK1(1), SPHK2(1), UGT8(1)	2650200	73	12	49	72	12	28	3	25	5	0	1.000	1.000	1.000
378	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	AFMID(1), CS(5), GRHPR(4), HAO1(1), HYI(1), MDH2(5), MTHFD1(4)	968063	21	12	15	24	4	6	1	7	3	0	1.000	1.000	1.000
379	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT1(2), ACAT2(1), ACOT11(5), ACYP1(1), DHRS1(2), DHRS2(2), DHRSX(1), ECHS1(1), EHHADH(3), ESCO1(1), PNPLA3(5), YOD1(1)	1885055	25	12	21	27	5	10	0	10	0	0	1.000	1.000	1.000
380	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	14	BPNT1(1), CHST11(1), CHST12(4), CHST13(2), PAPSS1(5), PAPSS2(1), SULT1A1(3), SULT1A2(3), SULT2B1(3), SUOX(1)	850793	24	12	20	17	7	5	0	10	2	0	0.993	1.000	1.000
381	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	33	GTF2A1(1), GTF2A1L(2), GTF2E1(1), GTF2F1(3), GTF2I(2), GTF2IRD1(1), STON1(3), TAF1(3), TAF1L(2), TAF2(2), TAF4(1), TAF4B(2), TAF5L(2), TAF6(1), TAF6L(1), TAF7L(5), TBPL2(4)	2721143	36	12	33	51	4	10	2	15	5	0	1.000	1.000	1.000
382	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	EIF2B5(4), EIF2S2(1), EIF2S3(2), INPPL1(1), PDPK1(1), PIK3CA(2), PPP2CA(1), PTEN(2)	1483847	14	12	13	24	2	5	0	5	2	0	1.000	1.000	1.000
383	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CD3D(1), CD3G(2), ETV5(1), IL12B(2), IL12RB1(8), IL12RB2(2), IL18R1(1), JAK2(2), MAPK8(1), TYK2(3)	1381689	23	12	19	25	5	5	2	8	3	0	1.000	1.000	1.000
384	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	GRB2(1), IL4R(15), IRS1(2), JAK1(2), JAK3(2), STAT6(4)	1084453	26	12	19	26	5	9	6	4	2	0	1.000	1.000	1.000
385	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	CAPN2(4), EGF(4), EGFR(4), ITGA1(3), MYLK(8), PRKACG(2), PTK2(2), TLN1(6)	2464145	33	12	24	50	7	9	2	12	3	0	1.000	1.000	1.000
386	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(1), GALNT10(1), GALNT2(2), GALNT4(5), GALNT6(1), GALNT8(8), GALNT9(1), GCNT1(4), ST3GAL4(3), WBSCR17(1)	1076400	27	12	19	36	2	12	1	9	3	0	1.000	1.000	1.000
387	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	CCND1(1), CDKN1A(4), CDKN1B(1), E2F1(2), NFKB1(3), NFKBIA(3), PIK3CA(2), RAC1(1), RAF1(4), RB1(1)	1489831	22	12	20	25	4	7	0	5	6	0	1.000	1.000	1.000
388	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(4), ACP2(3), ACP5(1), ACPT(8), ENPP1(3), ENPP3(3), FLAD1(1), TYR(9)	720331	32	12	17	13	10	8	2	10	2	0	0.646	1.000	1.000
389	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	AKT2(1), BPNT1(1), GRB2(1), ILK(1), PIK3CA(2), PIK3CD(1), PTEN(2), PTK2B(4), RBL2(3), SOS1(1)	1478442	17	12	14	37	3	4	0	5	5	0	1.000	1.000	1.000
390	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(1), CCND1(1), CDKN1B(1), CDKN2A(1), E2F1(2), E2F2(3), PRB1(9)	659154	18	12	12	10	3	8	1	3	3	0	0.810	1.000	1.000
391	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	CBS(2), CTH(2), GGT1(6), MAT2B(1), PAPSS1(5), PAPSS2(1), SCLY(3)	916094	20	12	13	15	5	5	0	8	2	0	0.976	1.000	1.000
392	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	14	C9orf47(1), CNR2(4), DNMT1(2), MTNR1A(2), MTNR1B(2), PTAFR(2), PTGFR(1), PTGIR(2)	848418	16	12	14	36	2	9	1	4	0	0	1.000	1.000	1.000
393	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	ASAH1(4), BFAR(4), BRAF(3), RAF1(4), SNX13(1), TERF2IP(1)	848206	17	12	13	11	0	11	1	4	1	0	0.915	1.000	1.000
394	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	9	AKAP9(8), MAP2(2), PPP1CA(1), PPP2CA(1), PRKACG(2)	1224276	14	11	10	21	0	7	0	7	0	0	1.000	1.000	1.000
395	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD80(2), HLA-DRA(2), HLA-DRB1(46)	284773	50	11	36	27	5	21	1	21	2	0	0.937	1.000	1.000
396	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	HLA-DRA(2), HLA-DRB1(46)	169872	48	11	34	22	5	19	1	21	2	0	0.766	1.000	1.000
397	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	ACHE(1), CHAT(4), DBH(7), DDC(3), GAD1(2), GAD2(1), HDC(4), PAH(1), TH(3)	1060398	26	11	18	33	14	5	1	6	0	0	1.000	1.000	1.000
398	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(4), CYP11B1(3), CYP11B2(5), HSD3B1(2), HSD3B2(2)	662195	16	11	13	25	6	5	3	1	1	0	1.000	1.000	1.000
399	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	BIRC2(1), CASP1(1), CASP10(2), CASP2(1), CASP4(2), CASP7(3), CASP8(3), CASP9(4), DFFA(1), GZMB(5), LMNA(3), PRF1(2)	1424390	28	11	22	36	7	5	3	9	4	0	1.000	1.000	1.000
400	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CCL2(1), CCL4(3), CXCR4(4), MAPK8(1), PLCG1(3), PTK2B(4)	987940	16	11	11	25	1	3	3	6	3	0	1.000	1.000	1.000
401	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5R1(1), DRD2(1), GRM1(2), PLCB1(8), PPP1CA(1), PPP2CA(1), PPP3CA(1), PRKACG(2)	1180726	17	11	14	29	0	2	0	7	8	0	1.000	1.000	1.000
402	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CSF2(1), FLT3(1), IL11(1), IL1A(2), IL3(3), IL6(2), IL9(1), KITLG(1), TGFB2(1)	631490	13	11	11	12	5	5	0	3	0	0	0.970	1.000	1.000
403	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(1), F2(1), F2R(1), F5(18), F7(3), FGA(2), FGB(1), FGG(1), PROC(2), PROS1(1), SERPINC1(1)	1207552	32	11	23	39	8	20	0	4	0	0	1.000	1.000	1.000
404	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(2), F13A1(8), F2(1), F2R(1), FGA(2), FGB(1), FGG(1), PLAT(1), PLG(4), SERPINB2(4), SERPINE1(1)	974522	26	11	18	31	4	13	0	9	0	0	1.000	1.000	1.000
405	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSA(4), ARSB(5), ARSD(19), ARSE(1), ASAH1(4), GAL3ST1(4), GALC(3), GBA(2), GLB1(1), LCT(3), NEU2(3), NEU4(4), PPAP2B(1), SMPD2(7)	1799739	61	11	37	52	10	23	2	22	4	0	1.000	1.000	1.000
406	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(2), ACACB(12), FASN(3), MCAT(1)	1217851	18	11	15	23	11	4	1	2	0	0	1.000	1.000	1.000
407	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(4), CYP11B1(3), CYP11B2(5), HSD3B1(2), HSD3B2(2)	662195	16	11	13	25	6	5	3	1	1	0	1.000	1.000	1.000
408	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT2(3), IARS(2), LARS(4), PDHA2(2), VARS(3), VARS2(10)	1352774	24	11	17	40	5	14	1	3	1	0	1.000	1.000	1.000
409	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	DHRS1(2), DHRS2(2), DHRSX(1), HSD3B7(2), PON1(6), PON2(3), RDH12(3)	649246	19	11	14	20	5	5	0	9	0	0	0.999	1.000	1.000
410	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(5), GALNS(2), GLB1(1), GUSB(1), HEXB(5), HGSNAT(1), HPSE(2), HPSE2(6), IDS(1), IDUA(5), LCT(3), NAGLU(3)	1543835	35	11	24	43	13	11	2	9	0	0	1.000	1.000	1.000
411	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(1), AGPAT2(1), CHPT1(2), ENPP2(3), PLA2G2D(1), PLA2G3(4), PLA2G4A(1), PLA2G5(1), PLD1(4), PLD2(13), PPAP2B(1)	1736404	32	11	22	36	8	8	4	7	5	0	1.000	1.000	1.000
412	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(6), AMT(1), ATIC(1), FTCD(1), GART(3), MTHFD1(4), MTHFR(4), MTR(4), SHMT1(3), SHMT2(1)	1405984	28	11	20	22	5	17	1	5	0	0	0.989	1.000	1.000
413	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	EPX(3), LPO(2), MTHFR(4), SHMT1(3), SHMT2(1), TPO(10)	846904	23	11	18	24	6	8	2	7	0	0	1.000	1.000	1.000
414	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(2), AOC2(2), AOC3(4), CES1(12), DDHD1(1), ESCO1(1), LIPA(3), PLA1A(2), PNPLA3(5)	1854740	32	11	24	15	6	13	0	10	3	0	0.830	1.000	1.000
415	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACAA1(3), ACOX1(7), ACOX3(1), ELOVL6(1), FASN(3), HSD17B12(2), PECR(4), SCD(2)	1132589	23	11	17	18	7	6	0	10	0	0	0.985	1.000	1.000
416	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG12(1), ATG3(1), ATG7(1), IFNA1(2), IFNA10(4), IFNA13(1), IFNA14(2), IFNA16(4), IFNA17(1), IFNA4(4), IFNA5(1), PIK3C3(1), PIK3R4(1), PRKAA1(1), ULK1(3), ULK2(1), ULK3(3)	1574589	32	11	29	20	5	12	1	10	4	0	0.945	1.000	1.000
417	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	EPX(3), LPO(2), SHMT1(3), SHMT2(1), TPO(10)	872150	19	11	15	19	6	6	2	5	0	0	0.999	1.000	1.000
418	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(2), FUCA1(2), FUCA2(8), GLB1(1), HEXB(5), LCT(3), MANBA(7), NEU2(3), NEU4(4)	1250472	35	11	18	33	10	16	3	5	1	0	1.000	1.000	1.000
419	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	DLG4(1), GRIN2A(2), GRIN2B(2), GRIN2C(3), GRIN2D(1), NOS1(3), PPP3CA(1), PPP3CC(1), PRKACG(2)	1912188	16	11	13	55	5	5	0	5	1	0	1.000	1.000	1.000
420	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(6), AMT(1), ATIC(1), GART(3), MTHFD1(4), MTHFR(4), MTR(4), SHMT1(3), SHMT2(1)	1303963	27	11	19	19	4	17	1	5	0	0	0.970	1.000	1.000
421	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	NFKB1(3), NFKBIA(3), PLCB1(8)	608492	14	11	11	14	1	1	0	3	9	0	0.999	1.000	1.000
422	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	GTF2A1(1), GTF2E1(1), GTF2F1(3), NCOA1(2), NCOA2(1), NCOA3(3), NCOR2(9), TBP(2)	1867153	22	11	21	34	6	8	1	3	4	0	1.000	1.000	1.000
423	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	37	GTF2E1(1), ILK(1), POLR1A(3), POLR1B(2), POLR2B(1), POLR2E(1), POLR3E(1), TAF6(1), TBP(2)	2586925	13	11	13	54	4	3	0	4	2	0	1.000	1.000	1.000
424	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	BIRC2(1), CASP10(2), CASP7(3), CASP8(3), CASP9(4), DFFA(1), GZMB(5), PRF1(2), SCAP(3), SREBF1(1), SREBF2(5)	1391676	30	11	22	21	9	6	3	11	1	0	0.987	1.000	1.000
425	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR2(1), ITPKA(1), PDE1B(1), PLCB1(8), TRH(2)	818032	13	11	10	21	0	3	0	4	6	0	1.000	1.000	1.000
426	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL4R(15), JAK1(2), JAK2(2), TYK2(3)	764587	23	11	16	26	3	6	6	8	0	0	1.000	1.000	1.000
427	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL4R(15), JAK1(2), JAK2(2), TYK2(3)	764587	23	11	16	26	3	6	6	8	0	0	1.000	1.000	1.000
428	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ARPC1B(3), NCK1(2), NCKAP1(2), NTRK1(3), RAC1(1), WASF1(1), WASF3(3), WASL(1)	1125112	16	10	14	19	6	4	1	5	0	0	0.999	1.000	1.000
429	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	ADSS(1), AGXT(1), AGXT2(4), CAD(1), DDO(1), GAD1(2), GAD2(1), GOT2(4), GPT(1), PC(1)	1913999	17	10	14	35	5	2	1	9	0	0	1.000	1.000	1.000
430	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CYB5R3(1), GFPT1(1), HEXB(5), HK1(1), HK2(4), HK3(1), PGM3(1), UAP1(1)	1258083	15	10	11	31	2	8	0	4	1	0	1.000	1.000	1.000
431	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(2), ATP6V0A4(1), ATP6V0B(1), ATP6V1A(1), ATP6V1B1(2), ATP6V1C2(2), ATP6V1G3(1), ATP6V1H(1), SHMT1(3)	1106699	14	10	12	15	3	9	1	1	0	0	0.991	1.000	1.000
432	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	22	BCL2(1), CSF2RB(3), IL3(3), IL3RA(4), KITLG(1), PIK3CA(2), PRKACG(2)	1610040	16	10	10	40	2	4	0	10	0	0	1.000	1.000	1.000
433	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	17	CDKN1A(4), NFATC1(6), NFATC2(2), NFATC3(1), NFATC4(1), PLCG1(3), PPP3CA(1), PPP3CC(1), SP1(1), SP3(2)	1502460	22	10	18	24	4	7	2	8	1	0	1.000	1.000	1.000
434	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(1), EGF(4), EGFR(4), GRB2(1), MET(2), SH3GLB2(2)	1409572	14	10	12	39	1	9	0	2	2	0	1.000	1.000	1.000
435	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(3), ACTN2(1), BCAR1(2), CSK(3), CTNNA2(3), PTK2(2)	1433513	14	10	12	24	4	2	1	6	1	0	1.000	1.000	1.000
436	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	CAMK2G(1), GNAS(1), GRB2(1), PIK3CA(2), PRKACG(2), RAC1(1), RPS6KA1(2), RPS6KA5(1), SOS1(1)	2173768	12	10	10	51	2	4	0	5	1	0	1.000	1.000	1.000
437	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GGT1(6), SHMT1(3), SHMT2(1)	319924	10	10	6	5	3	3	0	4	0	0	0.789	1.000	1.000
438	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	GRB2(1), MAPK7(1), MEF2B(3), MEF2C(1), NTRK1(3), PIK3CA(2), PLCG1(3), RPS6KA1(2)	1459328	16	10	13	33	2	4	2	6	2	0	1.000	1.000	1.000
439	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(2), ATP6V0A4(1), ATP6V0B(1), ATP6V1A(1), ATP6V1B1(2), ATP6V1C2(2), ATP6V1G3(1), ATP6V1H(1), SHMT1(3)	1106699	14	10	12	15	3	9	1	1	0	0	0.991	1.000	1.000
440	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	8	GABRA1(2), GABRA2(2), GABRA3(1), GABRA4(4), GABRA5(1), GABRA6(3)	476131	13	10	10	8	1	7	0	5	0	0	0.923	1.000	1.000
441	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	GABRA1(2), GABRA2(2), GABRA3(1), GABRA4(4), GABRA5(1), GABRA6(3), GPHN(2), UBQLN1(1)	932848	16	10	13	15	1	7	0	8	0	0	0.999	1.000	1.000
442	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ALDH1A2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH3B2(3), ALDH9A1(3), AOC2(2), AOC3(4), CNDP1(8), DDC(3), HDC(4), HNMT(1)	1797143	39	10	32	37	13	12	1	9	4	0	1.000	1.000	1.000
443	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS2(5), CTH(2), GOT2(4), LDHA(1), LDHAL6A(2), LDHAL6B(7), SULT1C2(2), SULT1C4(3), SULT4A1(1)	922822	27	10	19	23	4	8	0	12	3	0	1.000	1.000	1.000
444	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(4), GAD1(2), GAD2(1), GGT1(6)	428172	13	10	9	9	4	2	0	7	0	0	0.943	1.000	1.000
445	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(1), ADH4(4), ADH7(2), ADHFE1(1), DHRS1(2), DHRS2(2), DHRSX(1), ESCO1(1), PNPLA3(5)	1804083	19	10	14	27	1	6	1	9	2	0	1.000	1.000	1.000
446	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	DHRS1(2), DHRS2(2), DHRSX(1), HEMK1(1), LCMT1(1), LCMT2(1), METTL2B(3), PRMT2(1), PRMT6(2), PRMT8(1)	1089110	15	10	12	18	3	9	0	2	1	0	0.998	1.000	1.000
447	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(3), APOBEC1(3), APOBEC2(2), APOBEC3B(3), APOBEC3C(1), APOBEC3F(3), APOBEC3G(1), APOBEC4(8)	527269	24	10	18	29	2	18	0	3	1	0	1.000	1.000	1.000
448	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(1), CA13(1), CA3(2), CA5A(1), CA6(5), CA9(5), CPS1(5), CTH(2), GLS(1), GLS2(2)	1540055	25	10	16	29	3	7	3	9	3	0	1.000	1.000	1.000
449	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(3), GBA(2), LPO(2), TPO(10)	618695	17	10	14	15	5	3	3	5	1	0	0.996	1.000	1.000
450	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(3), GOT2(4), TAT(2), TYR(9)	339632	18	10	13	11	8	4	0	6	0	0	0.928	1.000	1.000
451	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNA1(2), IFNAR1(4), IFNAR2(3), JAK1(2), STAT1(1), STAT2(3), TYK2(3)	795943	18	10	15	19	4	4	1	8	1	0	0.999	1.000	1.000
452	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(3), ICAM1(6), ITGA4(5), ITGAL(1), SELE(3), SELL(3)	892169	21	10	16	30	4	10	0	6	0	1	1.000	1.000	1.000
453	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(3), ACADM(1), ACADS(1), ACADVL(1), ACSL3(2), CPT2(5), EHHADH(3), PECR(4)	1226141	20	10	15	17	2	12	0	4	2	0	0.993	1.000	1.000
454	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(3), ICAM1(6), ITGA4(5), ITGAL(1), ITGAM(6), SELE(3), SELL(3), SELP(6)	1185802	33	10	25	39	7	17	0	8	0	1	1.000	1.000	1.000
455	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(6), ABCB11(2), ABCC1(3), ABCC3(5), GSTP1(1)	1054274	17	10	15	36	5	8	1	1	2	0	1.000	1.000	1.000
456	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	EIF4A2(1), EIF4G1(2), EIF4G2(1), EIF4G3(2), MKNK1(1), PDPK1(1), PIK3CA(2), PPP2CA(1), PTEN(2), TSC1(4)	2061261	17	10	17	34	3	4	1	6	3	0	1.000	1.000	1.000
457	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(1), B4GALT2(1), B4GALT3(2), B4GALT5(1), DPAGT1(2), FUT8(4), MAN1B1(1), MGAT1(6), MGAT4A(2), MGAT5(1), RPN2(1), ST6GAL1(3)	1490312	25	10	21	20	6	8	3	8	0	0	0.993	1.000	1.000
458	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(1), CA3(2), CA5A(1), CA6(5), CA9(5), CPS1(5), CTH(2), GLS(1), GLS2(2)	1378211	24	10	15	28	3	6	3	9	3	0	1.000	1.000	1.000
459	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CD2(1), CD3D(1), CD3G(2), IL12B(2), IL12RB1(8), IL12RB2(2), JAK2(2), TYK2(3)	1100637	21	10	17	24	5	4	1	9	2	0	1.000	1.000	1.000
460	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6V0A1(2), ATP6V0A4(1), ATP6V0B(1), ATP6V1A(1), ATP6V1B1(2), ATP6V1C2(2), ATP6V1G3(1), ATP6V1H(1), FDXR(2), SHMT1(3)	1175640	16	10	13	16	5	9	1	1	0	0	0.989	1.000	1.000
461	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	29	ANXA2(1), ANXA4(2), EDN1(3), EDNRA(1), HPGD(1), PLA2G4A(1), PTGFR(1), PTGIR(2), PTGIS(1), PTGS1(3), PTGS2(1), TBXAS1(5)	1618270	22	10	18	34	6	3	0	13	0	0	1.000	1.000	1.000
462	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	21	BTK(2), EEA1(4), LYN(2), PDPK1(1), PFKM(1), PLCG1(3), RAC1(1), VAV2(3)	1820945	17	10	14	42	4	5	2	4	2	0	1.000	1.000	1.000
463	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	CASP9(4), CHUK(1), ELK1(1), MAP2K1(2), NFKB1(3), PIK3CA(2), RAC1(1), RAF1(4), RALBP1(1), RALGDS(1), RHOA(2)	1448425	22	10	19	27	5	12	2	1	2	0	1.000	1.000	1.000
464	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5R1(1), DAB1(2), LRP8(3), RELN(9), VLDLR(2)	1008604	17	10	16	11	2	3	1	8	3	0	0.961	1.000	1.000
465	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	BCL10(2), BCL2(1), CASP9(4), CES1(12)	861646	19	10	12	20	4	8	1	3	3	0	0.999	1.000	1.000
466	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(4), JAK1(2), PTPRU(4), STAT1(1), STAT2(3), TYK2(3)	918688	17	10	14	20	4	4	1	7	1	0	1.000	1.000	1.000
467	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(2), ATP6V0A4(1), ATP6V0B(1), ATP6V1A(1), ATP6V1B1(2), ATP6V1C2(2), ATP6V1G3(1), ATP6V1H(1), SHMT1(3)	1106699	14	10	12	15	3	9	1	1	0	0	0.991	1.000	1.000
468	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(1), FDFT1(2), HMGCR(1), LSS(3), MVK(2), NQO1(4), NQO2(3), SQLE(1)	823173	17	9	14	29	3	8	3	1	2	0	1.000	1.000	1.000
469	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	CDK5R1(1), DPM2(1), EGR1(1), KLK2(1), MAP2K1(2), NGFR(2), RAF1(4)	621918	12	9	12	19	2	4	2	2	2	0	1.000	1.000	1.000
470	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	ARHGAP5(2), CASP1(1), CASP10(2), CASP8(3), CASP9(4), GZMB(5), PRF1(2)	925166	19	9	15	22	5	5	3	3	3	0	1.000	1.000	1.000
471	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(4), EGF(4), EGFR(4), HGS(1), TF(2), TFRC(2)	929705	17	9	14	30	3	9	0	5	0	0	1.000	1.000	1.000
472	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	EPHB1(3), ITGA1(3), L1CAM(1), LYN(2), SELP(6)	1140399	15	9	13	25	4	6	2	3	0	0	1.000	1.000	1.000
473	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(1), KHK(3), LCT(3), PGM1(4), PYGL(4)	1013251	15	9	10	25	4	8	0	1	2	0	1.000	1.000	1.000
474	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(1), ASPH(1), EDN1(3), EP300(5), LDHA(1)	1247726	11	9	8	17	1	5	0	5	0	0	1.000	1.000	1.000
475	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(1), FARSA(2), FARSB(1), GOT2(4), PAH(1), TAT(2), YARS2(2)	632714	13	9	11	18	2	3	1	6	1	0	1.000	1.000	1.000
476	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CHPT1(2), HEMK1(1), LCMT1(1), LCMT2(1), METTL2B(3), PCYT1B(1), PRMT2(1), PRMT6(2), PRMT8(1)	1023131	13	9	10	15	2	9	0	1	1	0	0.995	1.000	1.000
477	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	16	CHST11(1), CHST12(4), CHST13(2), CHSY1(3), DSE(8), UST(1), XYLT1(4), XYLT2(5)	1072776	28	9	20	24	6	10	0	12	0	0	0.997	1.000	1.000
478	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	EPHX2(6), HSD3B7(2), RDH12(3)	344273	11	9	7	11	4	4	0	0	3	0	0.987	1.000	1.000
479	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS1(2), DHRS2(2), DHRSX(1), ESCO1(1), PNPLA3(5)	1190333	11	9	9	14	1	4	0	6	0	0	0.999	1.000	1.000
480	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	66	MRPS7(1), RPL10L(2), RPL13(1), RPL14(1), RPL3(1), RPL37(1), RPL3L(2), RPL6(1)	1559020	10	9	10	31	5	3	1	0	1	0	1.000	1.000	1.000
481	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	GOSR2(2), SNAP25(1), STX16(2), STX17(3), STX18(1), STX2(2), TSNARE1(9), VTI1A(1)	1245829	21	9	16	25	5	7	1	5	3	0	1.000	1.000	1.000
482	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(1), CD3D(1), CD3G(2), CD58(1), IL3(3), IL6(2), KITLG(1)	460709	11	9	9	17	1	5	0	3	2	0	1.000	1.000	1.000
483	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(1), B4GALT2(1), B4GALT3(2), B4GALT5(1), FUT8(4), ST3GAL4(3)	568409	12	9	9	17	4	0	0	5	3	0	1.000	1.000	1.000
484	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(2), LEPR(10), PRKAA1(1)	1041897	13	9	7	14	1	3	6	3	0	0	0.996	1.000	1.000
485	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), ECHS1(1), EHHADH(3)	896625	18	9	17	19	4	8	0	5	1	0	0.999	1.000	1.000
486	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	19	BCL2(1), BIRC2(1), CASP7(3), CASP8(3), CASP9(4), DFFA(1), ENDOG(2)	991943	15	9	12	19	2	5	1	6	1	0	1.000	1.000	1.000
487	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(2), BIN1(1), EPS15(3), PPP3CA(1), PPP3CC(1), SYNJ1(2), SYNJ2(3)	1686103	13	9	10	32	1	7	0	3	2	0	1.000	1.000	1.000
488	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(1), ADORA3(4), P2RY1(1), P2RY2(5), P2RY6(1)	424295	12	9	8	7	5	1	0	6	0	0	0.822	1.000	1.000
489	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(1), ENO3(2), FARS2(1), GOT2(4), PAH(1), TAT(2)	595778	11	9	9	14	2	4	0	5	0	0	0.999	1.000	1.000
490	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMB1(3), PSMB2(1), PSMB4(1), PSMB5(2), PSMB7(1), RPN2(1), UBE2A(4)	968825	13	9	10	14	2	3	0	3	5	0	0.999	1.000	1.000
491	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	ADAM17(1), APC(4), BTRC(1), DVL1(1), FZD1(1), NOTCH1(2), PSEN1(1)	1638098	11	9	11	29	3	3	1	3	1	0	1.000	1.000	1.000
492	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	BCAR1(2), CDKN1B(1), GRB2(1), ILK(1), PDPK1(1), PIK3CA(2), PTEN(2), PTK2(2), SOS1(1)	1450523	13	9	13	36	3	3	0	4	3	0	1.000	1.000	1.000
493	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	AKT2(1), CDKN1A(4), ELK1(1), GRB2(1), MAP2K1(2), NGFR(2), NTRK1(3), PIK3CA(2), PIK3CD(1), SOS1(1)	1236506	18	9	17	25	5	5	2	4	2	0	1.000	1.000	1.000
494	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(4), CKM(1), GPT(1), LDHA(1), NCL(4)	663110	11	9	10	18	3	4	0	1	3	0	1.000	1.000	1.000
495	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CDC25C(4), CSK(3), GRB2(1), PTPRA(2)	678402	10	9	9	13	3	1	1	2	3	0	0.999	1.000	1.000
496	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	F13B(1), HSD17B1(2), HSD17B4(4), HSD17B7(4), HSD3B1(2), HSD3B2(2)	589135	15	9	12	17	3	9	2	1	0	0	0.996	1.000	1.000
497	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(1), CD3D(1), CD3G(2), ICAM1(6), ITGAL(1), PTPRC(1)	767381	12	9	9	20	1	4	0	6	1	0	1.000	1.000	1.000
498	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(1), CD3D(1), CD3G(2), ICAM1(6), ITGAL(1), PTPRC(1)	809519	12	9	9	18	1	4	0	6	1	0	1.000	1.000	1.000
499	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	DPM2(1), GRB2(1), KLK2(1), NTRK1(3), PIK3CA(2), PLCG1(3), SOS1(1)	1141683	12	9	11	22	2	4	2	3	1	0	1.000	1.000	1.000
500	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3)	588587	14	8	13	16	4	5	0	4	1	0	0.999	1.000	1.000
501	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(2), AGT(4), AGTR1(2), AGTR2(3), KNG1(6)	741110	17	8	14	17	4	3	0	10	0	0	0.998	1.000	1.000
502	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	CHRNG(1), MUSK(5), PIK3CA(2), PTK2(2), PTK2B(4), RAPSN(1), TERT(1)	1234919	16	8	13	34	5	3	0	4	4	0	1.000	1.000	1.000
503	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARFGAP3(2), CLTB(1), COPA(1), GBF1(2), GPLD1(5), KDELR3(3)	1176426	14	8	9	17	5	4	0	4	1	0	0.999	1.000	1.000
504	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3)	588587	14	8	13	16	4	5	0	4	1	0	0.999	1.000	1.000
505	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CAMK1G(1), CAMK2G(1), CAMK4(1), CAMKK1(1), CAMKK2(5)	875442	9	8	7	26	2	2	0	4	1	0	1.000	1.000	1.000
506	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(8), CDC25C(4), MYT1(1)	1014844	13	8	10	14	3	7	0	3	0	0	0.995	1.000	1.000
507	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLD1(2), POLE(4), POLG(2), POLL(1), POLQ(15)	1233070	24	8	20	24	4	10	2	7	1	0	0.999	1.000	1.000
508	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	CASP7(3), DFFA(1), ENDOG(2), GZMB(5), HMGB2(1), TOP2A(3), TOP2B(2)	775933	17	8	13	17	1	3	2	10	1	0	1.000	1.000	1.000
509	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(1), CDKN1A(4), EPOR(1), JAK2(2), NFKB1(3), NFKBIA(3)	967345	14	8	12	18	2	3	0	6	3	0	1.000	1.000	1.000
510	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(4), EGFR(4), ERBB3(1), NRG1(4)	739620	13	8	10	14	2	6	0	5	0	0	0.998	1.000	1.000
511	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(1), ERBB4(4), NRG2(1), NRG3(2), PSEN1(1)	663032	9	8	8	15	2	1	0	4	2	0	1.000	1.000	1.000
512	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	GPD2(3), SDHA(6), SDHC(1), UQCRC1(1)	473181	11	8	9	18	6	1	0	3	1	0	1.000	1.000	1.000
513	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(5), GALNS(2), GLB1(1), GUSB(1), HEXB(5), IDS(1), IDUA(5), LCT(3), NAGLU(3)	1077485	26	8	17	38	12	9	2	3	0	0	1.000	1.000	1.000
514	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(1), CYSLTR2(2), GPR171(1), GPR18(1), GPR34(1), GPR39(3), GPR45(1), GPR68(1), GPR75(1)	715879	12	8	11	12	1	9	0	1	1	0	0.986	1.000	1.000
515	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3)	631532	14	8	13	28	3	5	0	5	1	0	1.000	1.000	1.000
516	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	BHMT(1), CBS(2), CTH(2), DNMT1(2), DNMT3B(1), MAT2B(1), MTAP(2), MTR(4), SRM(1), TAT(2)	1528170	18	8	14	23	4	8	0	4	2	0	1.000	1.000	1.000
517	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	HK1(1), HK2(4), HK3(1), IMPA2(1), PGM1(4), PGM3(1)	877141	12	8	10	29	2	7	0	2	1	0	1.000	1.000	1.000
518	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(7), ACOX3(1), PLA2G2D(1), PLA2G3(4), PLA2G4A(1), PLA2G5(1)	790092	15	8	13	12	5	3	1	6	0	0	0.980	1.000	1.000
519	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B4GALNT1(3), GLB1(1), HEXB(5), LCT(3), SLC33A1(1), ST3GAL5(3), ST6GALNAC3(1)	1198130	17	8	11	23	1	12	1	3	0	0	1.000	1.000	1.000
520	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH4(4), ADH7(2), ADHFE1(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3)	978665	21	8	17	26	3	7	1	7	3	0	1.000	1.000	1.000
521	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(2), ACSS1(2), ACSS2(1), IDH1(1), MDH2(5)	964320	11	8	7	15	3	4	1	3	0	0	0.999	1.000	1.000
522	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	ECHS1(1), EHHADH(3), HSD17B4(4), NTAN1(4), SIRT1(2), SIRT5(1)	867807	15	8	12	18	0	8	1	5	1	0	1.000	1.000	1.000
523	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(3), POLR1B(2), POLR2B(1), POLR2E(1), POLR3A(4)	1688473	11	8	10	41	2	4	0	5	0	0	1.000	1.000	1.000
524	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	CS(5), OGDH(2), SDHA(6)	684984	13	8	9	24	5	0	0	5	3	0	1.000	1.000	1.000
525	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(2), CCL2(1), CSF1(2), IL6(2), LDLR(3), LPL(1)	385027	11	8	7	15	1	4	2	3	1	0	1.000	1.000	1.000
526	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	CDC25C(4), GNAS(1), GNGT1(1), MYT1(1), PRKACG(2), RPS6KA1(2)	1534712	11	8	8	37	5	0	0	6	0	0	1.000	1.000	1.000
527	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(3), ICAM1(6), ITGAL(1), ITGAM(6), SELE(3), SELL(3)	785544	22	8	16	23	3	14	0	5	0	0	0.999	1.000	1.000
528	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	CDK5R1(1), CSNK1A1(2), MAPT(16), PPP2CA(1)	721733	20	8	11	13	8	9	0	1	2	0	0.883	1.000	1.000
529	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	IFNAR1(4), IFNAR2(3), MAPK8(1), NFKB1(3), TNFRSF11A(3), TRAF6(1)	800175	15	8	10	10	3	4	1	5	2	0	0.950	1.000	1.000
530	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	MMP14(4), MMP2(1), MMP9(3), RECK(2), TIMP2(1), TIMP4(1)	567106	12	8	9	24	4	1	2	4	1	0	1.000	1.000	1.000
531	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDKN1A(4), NEK1(8)	565779	12	8	9	11	3	6	0	3	0	0	0.983	1.000	1.000
532	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(1), JAK1(2), JAK2(2), JAK3(2), PIAS1(1), PTPRU(4), SOAT1(1)	1038087	13	8	12	21	4	4	1	4	0	0	1.000	1.000	1.000
533	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	HK1(1), HK2(4), HK3(1), PGM1(4), PGM3(1)	766618	11	8	9	22	2	6	0	2	1	0	1.000	1.000	1.000
534	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	NRF1(1), UBE2A(4), UBE2D3(1), UBE2E3(1), UBE2J1(1)	771387	8	8	8	18	1	1	0	1	5	0	1.000	1.000	1.000
535	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ALDH18A1(2), CKM(1), CPS1(5), GAMT(1), OTC(4)	1372499	13	8	8	20	3	5	0	4	1	0	1.000	1.000	1.000
536	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(2), CYP2E1(1), PTGS1(3), PTGS2(1)	381456	7	7	6	8	1	1	0	5	0	0	0.998	1.000	1.000
537	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(15), PRKACG(2)	742959	17	7	13	15	6	4	0	7	0	0	0.995	1.000	1.000
538	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	EPRS(2), FARS2(1), GARS(1), IARS(2), LARS(4), QARS(1), RARS(2), SARS(1), WARS2(1)	2301515	15	7	10	48	1	10	0	4	0	0	1.000	1.000	1.000
539	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADRB2(3), CFTR(5), GNAS(1), PRKACG(2)	971932	11	7	7	30	1	5	0	3	2	0	1.000	1.000	1.000
540	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	DHCR7(1), FDFT1(2), HMGCR(1), LSS(3), MVK(2), NSDHL(1), SQLE(1)	977112	11	7	10	31	3	4	2	1	1	0	1.000	1.000	1.000
541	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(3), ACAA2(3), ACAT1(2), ACAT2(1), ECHS1(1), EHHADH(3), HADHB(1)	617928	14	7	10	11	0	8	0	5	1	0	0.983	1.000	1.000
542	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	NFKB1(3), TNF(3), XDH(6)	738471	12	7	9	11	1	7	0	1	3	0	0.989	1.000	1.000
543	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(3), FUT1(1), FUT2(1), GBGT1(4), HEXB(5), NAGA(1), ST3GAL4(3)	731897	18	7	10	23	1	10	0	2	5	0	1.000	1.000	1.000
544	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	B3GALT5(1), B3GNT5(2), FUT1(1), FUT2(1), FUT3(6), ST3GAL4(3)	522310	14	7	9	14	2	3	0	6	3	0	0.996	1.000	1.000
545	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(3), B3GALNT1(3), B3GALT5(1), FUT1(1), FUT2(1), GBGT1(4), HEXB(5), NAGA(1)	775409	19	7	11	19	1	14	0	2	2	0	0.996	1.000	1.000
546	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	GRB2(1), IRS1(2), MAP2K1(2), PIK3CA(2), RAF1(4), SOS1(1)	1373965	12	7	12	25	2	6	1	1	2	0	1.000	1.000	1.000
547	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	BHMT(1), CBS(2), CTH(2), DNMT1(2), DNMT3B(1), MAT2B(1), MTR(4)	1280246	13	7	10	20	1	7	0	3	2	0	1.000	1.000	1.000
548	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	CTSD(1), GREB1(6), MTA1(4), TUBA8(3)	848385	14	7	10	14	10	2	0	2	0	0	0.983	1.000	1.000
549	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(7), GAD1(2), HDC(4), TH(3)	442339	16	7	9	16	11	0	1	4	0	0	0.993	1.000	1.000
550	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CAMK1G(1), CAMK2G(1), CAMK4(1), MEF2B(3), MEF2C(1), PPARA(1), PPP3CA(1), PPP3CC(1), SLC2A4(1)	1563287	11	7	10	42	3	3	0	3	2	0	1.000	1.000	1.000
551	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	12	ADRB2(3), GNAS(1), PLCE1(8), PRKACG(2)	1114755	14	7	12	32	2	6	1	5	0	0	1.000	1.000	1.000
552	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMB1(3), PSMB2(1), PSMB4(1), PSMB5(2), PSMB7(1), PSMB8(1), PSMB9(2)	639812	11	7	7	14	4	2	0	4	1	0	0.999	1.000	1.000
553	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CDC25C(4), SHH(1), XPO1(3)	639780	8	7	6	11	6	0	0	2	0	0	0.998	1.000	1.000
554	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RANBP2(10)	586001	10	7	6	8	1	6	1	2	0	0	0.910	1.000	1.000
555	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	CASP8(3), TNF(3), TNFRSF1B(3)	611399	9	7	8	15	1	2	0	4	2	0	1.000	1.000	1.000
556	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(1), JAK1(2), JAK2(2), PTPRU(4), STAT1(1)	836344	10	7	9	25	2	4	0	4	0	0	1.000	1.000	1.000
557	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CSF1(2), CSF2(1), IL11(1), IL3(3), IL6(2), IL9(1)	460993	10	7	7	21	2	5	2	1	0	0	1.000	1.000	1.000
558	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD3D(1), CD3G(2), IL2RA(1), TGFB2(1), TGFBR3(2)	785579	7	7	7	15	1	2	0	2	2	0	1.000	1.000	1.000
559	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFS1(1), NDUFS2(3), NDUFV2(4)	520163	8	7	5	8	1	1	0	6	0	0	0.994	1.000	1.000
560	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	LPL(1), PPARG(3), TNF(3)	416737	7	7	6	11	0	1	0	4	2	0	1.000	1.000	1.000
561	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAD(2), ALAS2(1), CPO(5), UROS(1)	621764	9	6	7	16	2	5	0	2	0	0	1.000	1.000	1.000
562	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(2), ACAT2(1), ACYP1(1), ECHS1(1), EHHADH(3)	570606	8	6	7	10	0	4	0	4	0	0	0.999	1.000	1.000
563	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ARPC1B(3), PIK3CA(2), RAC1(1), WASL(1)	981086	7	6	6	10	2	1	0	4	0	0	0.999	1.000	1.000
564	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	HS3ST1(1), HS3ST3B1(1), XYLT1(4), XYLT2(5)	514100	11	6	9	24	2	3	0	5	1	0	1.000	1.000	1.000
565	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(4), CYP11B2(5), HSD3B1(2), HSD3B2(2)	502862	13	6	10	16	6	3	3	0	1	0	0.998	1.000	1.000
566	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	GRB2(1), PTK2B(4), SOS1(1)	636551	6	6	4	17	0	1	0	1	4	0	1.000	1.000	1.000
567	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(2), ALAS2(1), CPOX(1), PPOX(2), UROS(1)	568954	7	6	7	10	3	1	0	3	0	0	1.000	1.000	1.000
568	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	HS3ST1(1), HS3ST3B1(1), XYLT1(4), XYLT2(5)	514100	11	6	9	24	2	3	0	5	1	0	1.000	1.000	1.000
569	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ3(5), COQ5(2), COQ6(2), COQ7(2)	315346	11	6	5	6	4	6	1	0	0	0	0.733	1.000	1.000
570	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMB1(3), PSMB2(1), PSMB4(1), PSMB5(2), PSMB7(1), PSMD13(1), PSMD2(1)	1168763	10	6	7	17	2	3	0	4	1	0	1.000	1.000	1.000
571	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(1), SEC61A2(1), SRP68(1), SRP72(2), SRPR(1)	542736	6	6	6	13	3	1	0	1	1	0	1.000	1.000	1.000
572	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(1), ANKRD1(1), IL1A(2), IL1R1(1), MYOG(1), NR4A3(1), WDR1(1)	810356	8	6	8	21	3	1	0	3	1	0	1.000	1.000	1.000
573	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	13	GH1(2), GHR(2), PIK3CA(2)	960523	6	6	6	19	0	2	0	2	2	0	1.000	1.000	1.000
574	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(1), CBS(2), CTH(2), MUT(5)	364148	10	6	7	6	6	1	0	3	0	0	0.834	1.000	1.000
575	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ARPC1B(3), RAC1(1), WASF1(1), WASL(1)	602723	6	6	5	6	3	0	0	3	0	0	0.979	1.000	1.000
576	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CTH(2), GOT2(4), LDHA(1)	493188	7	5	5	12	1	1	0	5	0	0	1.000	1.000	1.000
577	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	ST3GAL4(3), ST3GAL5(3), ST6GALNAC2(1)	409943	7	5	3	11	1	3	0	0	3	0	0.995	1.000	1.000
578	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	ADRB2(3), GNAS(1), GNGT1(1), NFKB1(3), NPPA(1), PIK3CA(2)	1339315	11	5	9	23	3	4	0	2	2	0	1.000	1.000	1.000
579	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT2(4), TAT(2)	191112	6	5	5	9	2	1	0	3	0	0	0.999	1.000	1.000
580	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(2), GGPS1(1), IDI2(2), SQLE(1)	320695	6	5	6	12	0	0	2	1	3	0	1.000	1.000	1.000
581	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(2), CYP2C9(5)	144812	7	5	5	4	5	1	0	1	0	0	0.924	1.000	1.000
582	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNGR2(2), JAK1(2), JAK2(2), STAT1(1)	592569	7	5	6	21	1	4	0	2	0	0	1.000	1.000	1.000
583	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(5), PLCG1(3), PTK2B(4)	490665	12	5	6	17	3	1	2	3	3	0	1.000	1.000	1.000
584	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	ADAM17(1), FURIN(2), NOTCH1(2), PSEN1(1)	740733	6	5	6	12	4	1	0	0	1	0	0.999	1.000	1.000
585	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSS(1), POLD1(2), POLG(2), RRM1(1), SRM(1)	957892	7	5	6	15	2	2	1	2	0	0	1.000	1.000	1.000
586	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	IDH1(1), MDH2(5)	647342	6	5	4	9	1	4	1	0	0	0	0.996	1.000	1.000
587	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(2), POLR2B(1), POLR2E(1), POLRMT(4)	997709	8	5	8	39	1	4	0	3	0	0	1.000	1.000	1.000
588	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	LDLR(3), MBTPS1(1), SCAP(3), SREBF1(1), SREBF2(5)	931385	13	5	8	13	4	4	0	5	0	0	0.991	1.000	1.000
589	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	IARS(2), LARS(4), PDHA2(2)	724252	8	5	5	24	0	7	1	0	0	0	1.000	1.000	1.000
590	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH4(4), ADH7(2), ADHFE1(1)	405117	7	4	4	11	0	2	1	2	2	0	0.999	1.000	1.000
591	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	GNAS(1), GNGT1(1), PPP2CA(1), PRKAA1(1), PRKACG(2)	1146405	6	4	5	21	2	2	0	2	0	0	1.000	1.000	1.000
592	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	FABP6(2), LDLR(3)	388880	5	4	3	7	1	4	0	0	0	0	0.983	1.000	1.000
593	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	PGLYRP2(7)	132232	7	4	5	4	4	3	0	0	0	0	0.794	1.000	1.000
594	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1G(1), HDAC9(1), MEF2B(3), MEF2C(1)	634155	6	4	5	23	2	1	0	2	1	0	1.000	1.000	1.000
595	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	PARK2(3), SNCAIP(1)	451128	4	4	4	5	0	0	0	4	0	0	0.996	1.000	1.000
596	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(1), BMPR1A(3)	452082	4	4	3	9	2	0	0	2	0	0	1.000	1.000	1.000
597	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(2), ACAT2(1), OXCT1(2)	248068	5	4	4	5	1	1	1	2	0	0	0.975	1.000	1.000
598	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	GNAS(1), GNGT1(1), PRKACG(2)	732388	4	3	3	19	2	0	0	2	0	0	1.000	1.000	1.000
599	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	B3GNT1(1), FUT1(1), FUT2(1)	455083	3	3	3	6	2	0	0	1	0	0	0.996	1.000	1.000
600	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	ECHS1(1), EHHADH(3)	356381	4	3	4	4	0	3	0	1	0	0	0.933	1.000	1.000
601	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	OPRK1(1), PRKACG(2)	943548	3	3	2	27	1	0	0	2	0	0	1.000	1.000	1.000
602	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(1), ENO1(1), HK1(1)	674641	3	3	3	9	0	2	0	1	0	0	1.000	1.000	1.000
603	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	GNAS(1), GNGT1(1), PRKACA(1)	489989	3	3	3	6	3	0	0	0	0	0	0.998	1.000	1.000
604	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALT(2), UXS1(1)	371833	3	3	2	8	0	3	0	0	0	0	0.999	1.000	1.000
605	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALT(2), UXS1(1)	296956	3	3	2	8	0	3	0	0	0	0	0.999	1.000	1.000
606	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	BCL2(1), CASP8(3)	276675	4	3	4	11	2	0	0	1	1	0	1.000	1.000	1.000
607	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CD36(1), THBS1(5)	517679	6	3	4	15	0	4	0	1	1	0	1.000	1.000	1.000
608	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	KEAP1(1), MAPK8(1)	680914	2	2	2	13	0	1	1	0	0	0	1.000	1.000	1.000
609	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	PLCD1(2)	372890	2	2	1	13	2	0	0	0	0	0	1.000	1.000	1.000
610	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A2(1)	273918	1	1	1	7	1	0	0	0	0	0	1.000	1.000	1.000
611	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	RAB9A(1)	312573	1	1	1	6	0	1	0	0	0	0	1.000	1.000	1.000
612	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	FMOD(1)	260296	1	1	1	5	0	0	1	0	0	0	0.999	1.000	1.000
613	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2		121917	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
614	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		36378	0	0	0	3	0	0	0	0	0	0	1.000	1.000	1.000
615	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2		156741	0	0	0	3	0	0	0	0	0	0	1.000	1.000	1.000
616	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2		109350	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
