rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1	CMBL(2)	386575	2	2	2	0	0	0	0	0	2	0	0.660	0.290	1.000
2	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	7	CCNE1(5), CDC34(4), CUL1(11), RB1(18), TFDP1(2)	4986845	40	35	40	7	3	12	5	3	17	0	0.0419	0.297	1.000
3	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(2), PAPSS1(6), PAPSS2(6), SULT1A2(1), SULT1E1(5), SULT2A1(2), SUOX(2)	4644911	24	22	24	2	5	7	5	5	2	0	0.0310	0.455	1.000
4	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(2)	549130	2	2	2	1	1	0	0	1	0	0	0.796	0.558	1.000
5	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(3), PGLYRP2(6)	1383171	9	9	9	2	1	3	2	2	1	0	0.347	0.598	1.000
6	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(4), RAB11A(1), RAB1A(2), RAB27A(1), RAB3A(2), RAB4A(1), RAB5A(3)	3208378	14	14	14	1	5	4	2	2	1	0	0.0336	0.654	1.000
7	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(6), CYP2C9(7)	1537915	13	13	13	3	0	4	5	3	1	0	0.369	0.655	1.000
8	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALT(2), TGDS(3), UGDH(4), UXS1(2)	2921501	11	11	11	0	0	1	5	4	1	0	0.104	0.662	1.000
9	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(2), TPI1(4)	1256585	6	6	6	2	1	3	2	0	0	0	0.649	0.695	1.000
10	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(2), CDO1(2), CSAD(5), GAD1(4), GAD2(7), GGT1(4)	4376205	24	24	24	4	4	7	6	2	5	0	0.0654	0.725	1.000
11	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALT(2), TGDS(3), UGDH(4), UGP2(2), UXS1(2)	3720453	13	13	13	0	0	1	7	4	1	0	0.0736	0.763	1.000
12	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYC(2), RB1(18), SP1(3), SP3(3)	5049097	26	26	26	9	0	2	5	4	15	0	0.839	0.784	1.000
13	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD28(3), CD4(1), HLA-DRA(1), HLA-DRB1(2)	1800404	7	7	6	2	0	1	0	3	3	0	0.747	0.792	1.000
14	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	LPL(4), NR3C1(6), PPARG(1), RXRA(5)	4399391	16	16	16	1	2	4	6	2	2	0	0.0307	0.809	1.000
15	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(1), ALDH1A2(10), RDH5(1)	2966657	12	12	12	2	1	1	5	2	3	0	0.404	0.826	1.000
16	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(2), GSTZ1(1), HGD(4)	1694316	7	7	7	2	1	3	2	0	1	0	0.481	0.830	1.000
17	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(2), CDC25B(4), CHEK1(1), NEK1(9), WEE1(1)	5221484	17	17	17	1	4	3	6	1	3	0	0.124	0.841	1.000
18	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	CDK5(3), FOSB(1), GRIA2(16), JUND(1), PPP1R1B(2)	2839623	23	22	23	6	4	6	11	2	0	0	0.219	0.874	1.000
19	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(10), PARK2(4), SNCA(1), SNCAIP(3), UBE2L3(2), UBE2L6(2)	4889898	22	20	22	4	4	5	4	7	2	0	0.155	0.926	1.000
20	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCR3(6), HLA-DRA(1), HLA-DRB1(2), IL3(1), IL5(2)	2305423	12	12	11	4	0	4	4	0	4	0	0.598	0.946	1.000
21	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIPT1(1)	1160551	1	1	1	0	0	0	0	1	0	0	0.757	0.951	1.000
22	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(2), IFNG(2), IL12A(1), IL12B(4), IL18(1), IL2(2)	2267286	12	12	12	4	1	2	2	4	3	0	0.769	0.956	1.000
23	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(3), PLCD1(4), PRKCA(7), TGM2(4)	3760452	18	18	18	4	2	6	5	3	2	0	0.114	0.957	1.000
24	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	B3GNT1(3), FUT2(2), FUT9(11), GCNT2(5), ST8SIA1(3)	4694960	24	23	23	5	3	6	13	2	0	0	0.154	0.957	1.000
25	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	AOC2(5), AOC3(5), CES1(7), ESD(3)	4600242	20	19	20	3	2	9	7	0	2	0	0.0470	0.965	1.000
26	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3D(1)	860420	1	1	1	1	0	0	1	0	0	0	0.944	0.972	1.000
27	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	5	C3(16), C5(11), C7(12), C8A(8), C9(15)	8096275	62	53	61	12	10	19	20	9	4	0	0.0301	0.976	1.000
28	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	11	ATM(16), CDC25A(2), CDC25B(4), CDC25C(4), CDK4(5), CHEK1(1), MYT1(12), RB1(18), WEE1(1), YWHAH(2)	12721311	65	59	65	9	7	14	14	8	22	0	0.0329	0.980	1.000
29	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	FABP6(3), LDLR(5), NR0B2(1), NR1H3(1), NR1H4(6), RXRA(5)	4142702	21	20	20	4	4	6	6	1	4	0	0.117	0.981	1.000
30	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	FUT2(2), FUT3(3), FUT5(4), FUT6(2), ST3GAL3(4)	3898124	15	14	15	3	3	3	6	2	1	0	0.191	0.983	1.000
31	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	BPNT1(2), CHST11(4), CHST12(5), CHST13(5), PAPSS1(6), PAPSS2(6), SULT1A1(2), SULT1A2(1), SULT1E1(5), SULT2A1(2), SUOX(2)	7044363	40	37	40	7	10	7	11	8	4	0	0.0562	0.989	1.000
32	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(1), ECHS1(2), EHHADH(5), HADHA(3), SDS(1)	3683426	12	10	12	2	0	4	3	3	2	0	0.269	0.989	1.000
33	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(4)	1300338	4	4	4	3	0	1	2	0	1	0	0.872	0.989	1.000
34	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(4), PSMA2(1), PSMA3(2), PSMA5(1), PSMA6(2), PSMB1(1), PSMB10(3), PSMB2(1), PSMB3(1), PSMB4(2), PSMB5(3), PSMB6(1), PSMB7(1), PSMB8(1), PSMB9(1)	6634572	25	23	25	4	1	5	8	7	4	0	0.159	0.991	1.000
35	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(4), ACADM(3), ACADS(2), ECHS1(2), HADHA(3)	4111521	14	14	14	3	2	3	4	4	1	0	0.357	0.992	1.000
36	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(5), CYP2E1(6), NR1I3(1), PTGS1(7), PTGS2(4)	4058542	23	21	23	6	2	1	11	1	8	0	0.437	0.992	1.000
37	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT2(2), HMGCL(1), OXCT1(2)	2569006	5	5	5	2	1	0	1	1	2	0	0.781	0.993	1.000
38	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(3), B4GALT1(1), B4GALT2(5), B4GALT3(1), B4GALT5(3), FUT8(2), ST3GAL1(2), ST3GAL2(1), ST3GAL3(4), ST3GAL4(1)	6032901	23	21	23	4	6	3	7	2	5	0	0.180	0.994	1.000
39	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(6), FOSL1(3), FOSL2(10), IFNAR1(3), IFNAR2(2), MAPK8(4), NFKB1(5), RELA(2), TNFRSF11A(3), TNFSF11(1), TRAF6(3)	8440356	42	39	42	8	6	9	10	8	9	0	0.204	0.994	1.000
40	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(1), GOT2(3), TAT(1)	1997140	5	5	5	2	0	0	3	1	1	0	0.768	0.995	1.000
41	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(3), AASDHPPT(3), AASS(3), KARS(3)	3583040	12	12	12	3	1	1	2	3	5	0	0.515	0.996	1.000
42	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	13	AKT1(2), BAD(1), CASP9(1), CHUK(6), GH1(4), GHR(8), NFKB1(5), NFKBIA(1), PDPK1(4), PIK3R1(10), RELA(2), YWHAH(2)	9069885	46	41	45	9	5	12	11	7	11	0	0.114	0.996	1.000
43	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(2), ADH1B(2), ADH4(3), ADH6(1), ADH7(2), ADHFE1(4)	4282569	14	13	14	4	1	4	2	2	5	0	0.561	0.996	1.000
44	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(2), HLCS(1), SPCS1(2), SPCS3(1)	2321334	6	6	6	4	0	2	1	0	3	0	0.848	0.998	1.000
45	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCR3(6), CD4(1), HLA-DRA(1), HLA-DRB1(2), IL1B(1), IL4(1), IL5(2), IL5RA(3), IL6(2)	4052954	19	19	18	5	1	5	8	2	3	0	0.407	0.998	1.000
46	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(21), GNAS(12), GNB1(3), PRKACA(4), PRKAR1A(3)	5046187	43	36	42	9	15	6	13	6	3	0	0.0882	0.998	1.000
47	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(7), CCNE1(5), CDC34(4), CUL1(11), RB1(18), SKP2(4), TFDP1(2)	6468191	51	45	51	12	4	12	12	5	18	0	0.160	0.998	1.000
48	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(1), F13B(13), HSD17B1(2), HSD17B2(2), HSD17B3(2), HSD17B4(5), HSD17B7(1), HSD3B1(4), HSD3B2(4)	6158075	34	32	34	9	5	7	12	6	4	0	0.286	0.999	1.000
49	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(1), DCN(4), FMOD(7), KERA(4), LUM(2)	2757273	18	14	18	6	1	8	5	2	2	0	0.389	0.999	1.000
50	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD28(3), CD4(1), CD80(5), HLA-DRA(1), HLA-DRB1(2), IL2(2), IL4(1)	3017930	15	15	14	5	0	4	4	4	3	0	0.664	0.999	1.000
51	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ3(2), COQ5(7), COQ6(2), COQ7(2), NDUFA12(1), NDUFA13(3)	3047233	17	16	17	5	2	3	7	2	3	0	0.532	0.999	1.000
52	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	11	APAF1(12), ARHGAP5(10), ARHGDIB(1), CASP1(2), CASP10(2), CASP3(2), CASP9(1), GZMB(2), JUN(1), PRF1(4)	8920640	37	34	37	7	6	8	4	11	8	0	0.163	0.999	1.000
53	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	16	CD28(3), CD3D(1), CD80(5), CD86(2), CTLA4(2), HLA-DRA(1), HLA-DRB1(2), ICOS(1), IL2(2), ITK(3), LCK(5), PIK3R1(10), PTPN11(2)	8051580	39	33	38	7	0	8	8	9	14	0	0.133	0.999	1.000
54	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(4), FDPS(2), GGPS1(1), IDI1(1), IDI2(1)	3251066	9	9	9	3	2	5	1	1	0	0	0.406	0.999	1.000
55	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	10	CREB1(1), FOS(6), JUN(1), MAPK14(2), MAPK8(4), PRKCA(7)	4449572	21	19	21	6	1	6	6	3	5	0	0.364	0.999	1.000
56	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT2(2), ACYP1(1), ECHS1(2), EHHADH(5), GCDH(2), HADHA(3), SDHB(1), SDS(1)	5938441	17	16	17	3	2	4	5	4	2	0	0.219	0.999	1.000
57	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	SNAP25(3), STX1A(5)	2472973	8	8	8	3	4	0	3	1	0	0	0.726	0.999	1.000
58	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(1), CD34(6), CD3D(1), CD4(1), CD58(2), CD8A(2), IL3(1), IL6(2), KITLG(1)	4699278	17	16	17	5	2	2	3	4	6	0	0.578	1.000	1.000
59	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(1), GLS2(2), GLUD1(4), GLUD2(10)	3468502	17	17	17	6	4	2	4	3	4	0	0.686	1.000	1.000
60	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(4), BCKDK(6), CTH(3), MUT(5)	3728828	18	17	18	5	2	6	4	3	3	0	0.473	1.000	1.000
61	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(7), GOT1(1), GOT2(3), TAT(1), TYR(8)	3576674	20	18	20	6	2	3	10	1	4	0	0.520	1.000	1.000
62	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(4), FDPS(2), IDI1(1)	2430488	7	7	7	3	2	4	1	0	0	0	0.550	1.000	1.000
63	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(2), IFNGR1(4), IFNGR2(5), JAK1(11), JAK2(5), STAT1(7)	6222329	34	30	33	9	2	9	9	5	9	0	0.242	1.000	1.000
64	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(1), GPD2(5), NDUFA1(1), SDHA(7), SDHB(1), SDHC(1), UQCRC1(1)	5030336	17	17	16	4	1	5	6	4	1	0	0.336	1.000	1.000
65	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	18	CSNK2A1(7), ELK1(2), FOS(6), INSR(3), IRS1(4), JUN(1), MAP2K1(5), MAPK8(4), PIK3R1(10), PTPN11(2), RAF1(3), SHC1(3), SLC2A4(3), SOS1(9), SRF(1)	15828483	63	56	63	9	8	11	20	10	14	0	0.00693	1.000	1.000
66	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(3), SEC61A2(4), SRP54(2), SRP68(4), SRP72(1), SRPR(2)	5730942	16	15	16	3	2	8	5	1	0	0	0.202	1.000	1.000
67	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CD28(3), CD3D(1), CD4(1)	2438429	5	5	5	3	0	0	1	3	1	0	0.904	1.000	1.000
68	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	GNB1(3), HTR2C(3), PLCB1(21), TUB(3)	5432569	30	30	29	8	7	5	12	5	1	0	0.293	1.000	1.000
69	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA2(1), ACAT2(2), ECHS1(2), EHHADH(5), HADHA(3), HADHB(4), SDS(1)	6350763	18	16	18	4	1	3	8	4	2	0	0.416	1.000	1.000
70	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CASP3(2), CD36(2), FOS(6), FYN(5), JUN(1), MAPK14(2), THBS1(8)	5637356	26	24	26	7	3	7	5	7	4	0	0.239	1.000	1.000
71	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(3), AASDH(5), AASDHPPT(3), AASS(3), KARS(3)	5282395	17	17	17	5	1	1	3	6	6	0	0.603	1.000	1.000
72	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	ANP32A(1), APEX1(1), CREBBP(39), GZMA(2), GZMB(2), HMGB2(2), PRF1(4), SET(1)	8072642	52	44	51	12	10	8	13	10	10	1	0.114	1.000	1.000
73	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	11	CCNE1(5), CDKN1B(2), CKS1B(3), CUL1(11), RB1(18), RBX1(3), SKP2(4), TFDP1(2), UBE2M(2)	6380828	50	46	50	13	3	13	9	6	19	0	0.220	1.000	1.000
74	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(4), HK1(4), HK2(5), HK3(8), IMPA1(2), PGM1(5), PGM3(1), TGDS(3)	7766709	32	31	32	7	7	9	8	3	5	0	0.0943	1.000	1.000
75	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	16	CSNK2A1(7), ELK1(2), FOS(6), JUN(1), KLK2(2), MAP2K1(5), MAPK8(4), NGFR(1), PIK3R1(10), PLCG1(8), RAF1(3), SHC1(3), SOS1(9)	12509890	61	55	61	10	11	9	22	6	13	0	0.0327	1.000	1.000
76	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA1(1), NDUFA5(3), NDUFB2(2), NDUFB4(1), NDUFB6(1), NDUFS1(1), NDUFS2(3), NDUFV1(3)	5283313	15	14	15	3	3	5	5	1	1	0	0.283	1.000	1.000
77	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(1), ECHS1(2), HADH(4), HADHA(3), HADHB(4), HSD17B10(1), HSD17B4(5), MECR(3), PPT1(1), PPT2(2)	6441487	26	23	26	6	2	3	10	7	4	0	0.309	1.000	1.000
78	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(16), CDC25A(2), CDC25B(4), CDC25C(4), CHEK1(1), MYT1(12), WEE1(1), YWHAH(2)	10453443	42	37	42	7	7	9	11	8	7	0	0.120	1.000	1.000
79	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	11	AKT1(2), CAT(4), GH1(4), GHR(8), IGF1(1), IGF1R(13), PIK3R1(10), SHC1(3), SOD1(1), SOD2(1), SOD3(3)	8126349	50	43	50	11	10	11	14	9	6	0	0.0867	1.000	1.000
80	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(8), GAD1(4), HDC(4), PNMT(1), TH(3), TPH1(2)	4604224	22	22	22	8	3	2	11	1	5	0	0.649	1.000	1.000
81	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	CCL2(2), CSF1(2), IL6(2), LDLR(5), LPL(4)	4042609	15	15	14	5	2	5	6	1	1	0	0.487	1.000	1.000
82	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(5), CHPT1(2), HEMK1(1), LCMT1(2), LCMT2(7), METTL2B(4), METTL6(3), PCYT1A(2), PCYT1B(2), PRMT2(1), PRMT3(6), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(4)	10663831	47	41	47	9	11	11	12	6	7	0	0.0430	1.000	1.000
83	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(3), CDC25A(2), CDC25B(4), CDC25C(4), MNAT1(1), SHH(2), XPO1(6)	6560593	22	22	22	5	6	5	3	5	3	0	0.322	1.000	1.000
84	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ARG1(1), GLS(1), GLUD1(4), OAT(1), PRODH(1)	4210897	8	8	8	3	0	2	1	3	2	0	0.659	1.000	1.000
85	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(5), B4GALT7(2), HS3ST2(2), HS3ST3A1(3), HS3ST3B1(1), XYLT1(10), XYLT2(3)	5041172	26	25	26	8	4	3	7	7	5	0	0.440	1.000	1.000
86	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(5), B4GALT7(2), HS3ST2(2), HS3ST3A1(3), HS3ST3B1(1), XYLT1(10), XYLT2(3)	5041172	26	25	26	8	4	3	7	7	5	0	0.440	1.000	1.000
87	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(4), ST3GAL1(2), ST3GAL2(1), ST3GAL4(1), ST3GAL5(6), ST6GALNAC2(3), ST8SIA1(3)	4298913	20	19	20	7	4	4	6	2	4	0	0.426	1.000	1.000
88	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	20	CEBPB(1), CSNK2A1(7), ELK1(2), FOS(6), IL6(2), IL6R(5), IL6ST(4), JAK1(11), JAK2(5), JAK3(6), JUN(1), MAP2K1(5), PTPN11(2), RAF1(3), SHC1(3), SOS1(9), SRF(1), STAT3(6)	17770774	79	70	79	12	13	12	26	16	12	0	0.00304	1.000	1.000
89	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(12), BAD(1), BAK1(1), BAX(1), BCL10(1), BCL2(1), BCL2L1(2), BCL2L11(1), BID(3), CASP9(1), CES1(7)	8316255	31	30	31	7	6	8	5	5	7	0	0.305	1.000	1.000
90	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	8	CHUK(6), DNAJC3(2), EIF2S1(2), EIF2S2(6), NFKB1(5), NFKBIA(1), RELA(2)	6848557	24	23	24	9	4	5	5	3	7	0	0.753	1.000	1.000
91	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(10), PDXK(1), PSAT1(1)	3686452	12	10	12	6	1	2	1	6	2	0	0.874	1.000	1.000
92	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(7), ACO2(3), FH(3), IDH1(4), IDH2(1), MDH1(1), MDH2(1), SDHB(1), SUCLA2(1)	6763942	22	19	22	5	2	8	9	1	2	0	0.223	1.000	1.000
93	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	16	IL18(1), ITGB1(16), KLRC1(1), KLRC2(1), KLRC3(3), KLRC4(1), LAT(3), MAP2K1(5), PAK1(3), PIK3R1(10), PTK2B(4), PTPN6(2), SYK(8), VAV1(8)	11388222	66	54	65	12	14	8	14	9	21	0	0.0565	1.000	1.000
94	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	17	APAF1(12), BAK1(1), BAX(1), BCL2(1), BCL2L1(2), BID(3), BIK(1), BIRC2(2), BIRC3(2), CASP3(2), CASP6(5), CASP7(3), CASP9(1), DIABLO(2)	9317945	38	34	38	8	6	12	5	6	9	0	0.136	1.000	1.000
95	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	17	CSNK2A1(7), ELK1(2), FOS(6), IGF1(1), IGF1R(13), IRS1(4), JUN(1), MAP2K1(5), MAPK8(4), PIK3R1(10), PTPN11(2), RAF1(3), SHC1(3), SOS1(9), SRF(1)	15296528	71	62	71	11	12	13	22	11	13	0	0.00672	1.000	1.000
96	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	10	C1QA(3), C1R(4), C1S(6), C2(6), C3(16), C5(11), C7(12), C8A(8), C9(15)	11866188	81	67	80	18	12	28	25	11	5	0	0.0208	1.000	1.000
97	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	6	AKT1(2), PIK3R1(10), PLCB1(21), PLCG1(8), PRKCA(7), VAV1(8)	8080811	56	50	55	13	7	9	22	8	10	0	0.228	1.000	1.000
98	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	6	ATM(16), ATR(25), CDC25C(4), CHEK1(1), CHEK2(5), YWHAH(2)	11536354	53	48	53	9	4	16	10	14	9	0	0.120	1.000	1.000
99	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(5), ERBB4(21), NRG2(5), NRG3(17), PRKCA(7)	6834830	55	50	55	15	4	9	20	12	10	0	0.406	1.000	1.000
100	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	ATP6V0C(1), GGT1(4), SHMT1(1), SHMT2(2)	3159906	8	8	8	5	3	0	3	1	1	0	0.886	1.000	1.000
101	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	6	CREBBP(39), LPL(4), NCOA1(7), NCOA2(8), PPARG(1), RXRA(5)	10308805	64	51	63	14	7	13	19	14	10	1	0.105	1.000	1.000
102	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(1), DAG1(5), ITPKB(5)	4610024	11	9	11	4	1	3	4	1	2	0	0.609	1.000	1.000
103	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(4), CTH(3), GOT1(1), GOT2(3), LDHA(1), LDHB(1), LDHC(4), MPST(2)	5208192	19	17	19	6	4	1	11	2	1	0	0.604	1.000	1.000
104	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(1), CD8A(2), CSF1(2), EPO(2), IL2(2), IL3(1), IL4(1), IL5(2), IL6(2), IL7(1), IL9(2)	4619492	18	18	18	9	4	3	6	3	2	0	0.833	1.000	1.000
105	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(21), CREM(1), FHL5(5), FSHB(2), FSHR(12), GNAS(12), XPO1(6)	7305896	59	50	58	13	14	11	18	13	3	0	0.135	1.000	1.000
106	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(4), ADORA2A(2), ADORA2B(1), ADORA3(3), LTB4R(3), P2RY1(5), P2RY2(3), P2RY6(2)	4542113	23	21	22	9	4	7	8	2	2	0	0.333	1.000	1.000
107	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(4), PSMA2(1), PSMA3(2), PSMA5(1), PSMA6(2), PSMB1(1), PSMB2(1), PSMB3(1), PSMB4(2), PSMB5(3), PSMB6(1), PSMB7(1), PSMC3(2), PSMD14(1), RPN1(2), RPN2(6), UBE3A(6)	9796477	37	32	37	8	1	8	14	10	4	0	0.229	1.000	1.000
108	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	4	ADAM17(5), DLL1(5), FURIN(1)	3958653	11	11	11	5	3	3	2	1	2	0	0.738	1.000	1.000
109	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(4), CS(2), MDH1(1), ME1(2), PC(14), PDHA1(4)	7057566	27	27	27	8	4	7	6	5	5	0	0.331	1.000	1.000
110	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	6	HDAC1(1), MAX(1), MYC(6), SP1(3), SP3(3), WT1(3)	4746761	17	17	15	7	0	4	8	3	2	0	0.770	1.000	1.000
111	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(4), BMPR1B(4), BMPR2(6)	4760347	14	14	14	5	3	4	4	1	2	0	0.655	1.000	1.000
112	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	13	CUZD1(2), FOS(6), JUN(1), MAP2K1(5), MYC(6), NFKB1(5), NFKBIA(1), PLCB1(21), PRKCA(7), RAF1(3), RELA(2)	11000650	59	55	56	15	8	13	24	8	6	0	0.0898	1.000	1.000
113	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(1), MTMR1(1), MTMR2(5), MTMR6(4), NFS1(1), PHPT1(1), TPK1(3)	4868352	16	14	16	5	4	2	5	3	2	0	0.699	1.000	1.000
114	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(1), IFNG(2), IFNGR1(4), JAK1(11), JAK2(5), PLA2G2A(2), PTPRU(9), REG1A(13), STAT1(7)	8690684	54	48	53	14	8	16	13	7	10	0	0.108	1.000	1.000
115	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(4), EPHA4(11), EPHB1(16), FYN(5), ITGA1(4), ITGB1(16), L1CAM(10), LYN(8), RAP1B(3), SELP(15)	12007305	92	65	90	20	13	17	24	18	20	0	0.0719	1.000	1.000
116	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(2), RANBP2(14), RANGAP1(1)	6414010	17	17	17	9	3	4	5	1	4	0	0.941	1.000	1.000
117	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	13	AKT1(2), CREB1(1), MAPK7(6), MEF2A(3), MEF2B(5), MEF2D(1), NTRK1(3), PIK3R1(10), PLCG1(8), RPS6KA1(10), SHC1(3)	11207042	52	46	52	10	11	9	13	11	8	0	0.0766	1.000	1.000
118	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	13	C1QA(3), C1R(4), C1S(6), C2(6), C3(16), C5(11), C7(12), C8A(8), C9(15), MASP1(7), MASP2(5), MBL2(2)	14759177	95	74	93	21	14	30	26	17	8	0	0.0146	1.000	1.000
119	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD28(3), CD86(2), HLA-DRA(1), HLA-DRB1(2), IFNG(2), IFNGR1(4), IFNGR2(5), IL12A(1), IL12B(4), IL12RB1(4), IL12RB2(11), IL18(1), IL18R1(3), IL2(2), IL2RA(2), IL4(1), IL4R(8)	9615390	56	49	54	14	4	10	18	8	16	0	0.215	1.000	1.000
120	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	12	ABL1(8), MDM2(2), MYC(6), PIK3R1(10), POLR1A(10), POLR1B(4), POLR1C(2), RB1(18), TBX2(4), TWIST1(1)	12367648	65	58	62	14	6	10	13	11	25	0	0.149	1.000	1.000
121	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(1), FUT2(2), FUT9(11), GBGT1(4), GLA(3), HEXA(4), NAGA(5), ST3GAL1(2), ST3GAL2(1), ST3GAL4(1), ST8SIA1(3)	7710747	37	34	37	10	7	7	14	4	5	0	0.179	1.000	1.000
122	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	ASRGL1(1), GBA(3), GGT1(4), SHMT1(1), SHMT2(2)	4189992	11	11	11	5	5	2	2	1	1	0	0.639	1.000	1.000
123	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT2(2), BDH1(1), BDH2(1), HMGCL(1), HMGCS1(3), HMGCS2(2), OXCT1(2), OXCT2(1)	5469959	13	12	13	8	3	2	2	4	2	0	0.925	1.000	1.000
124	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM1(1), CALM2(2), CALM3(2), CCL2(2), CXCL12(3), CXCR4(2), FOS(6), JUN(1), MAPK14(2), MAPK8(4), PLCG1(8), PRKCA(7), PTK2B(4), SYT1(8)	10487659	52	46	52	13	7	9	19	13	4	0	0.142	1.000	1.000
125	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(7), DYRK1B(8), GLI2(15), GLI3(12), GSK3B(3), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), SHH(2), SMO(3), SUFU(3)	12661824	69	61	68	17	13	17	23	8	8	0	0.0737	1.000	1.000
126	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	18	CSNK2A1(7), ELK1(2), EPO(2), EPOR(2), FOS(6), JAK2(5), JUN(1), MAP2K1(5), MAPK8(4), PLCG1(8), PTPN6(2), RAF1(3), SHC1(3), SOS1(9), STAT5A(3), STAT5B(5)	15986399	67	60	67	12	13	17	24	4	9	0	0.00820	1.000	1.000
127	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	B3GALT1(2), B3GALT2(2), B3GALT5(1), B3GNT5(2), FUT2(2), FUT3(3), ST3GAL3(4), ST3GAL4(1)	5501975	17	16	17	7	4	2	7	2	2	0	0.746	1.000	1.000
128	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	16	B3GAT1(2), B3GAT2(1), B3GAT3(5), B4GALT7(2), CHPF(7), CHST11(4), CHST12(5), CHST13(5), CHST14(2), CHST7(2), CHSY1(3), DSE(2), UST(3), XYLT1(10), XYLT2(3)	10680334	56	51	56	12	14	5	19	11	7	0	0.0687	1.000	1.000
129	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	15	APAF1(12), ATM(16), BAX(1), BCL2(1), CCND1(4), CCNE1(5), CDK4(5), GADD45A(1), MDM2(2), PCNA(1), RB1(18)	13151754	66	59	66	14	4	16	10	13	23	0	0.168	1.000	1.000
130	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	9	CASP3(2), CASP7(3), GZMB(2), HMGB1(1), HMGB2(2), TOP2A(5), TOP2B(4)	6712693	19	16	19	9	3	6	5	2	3	0	0.928	1.000	1.000
131	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	22	CDC34(4), TAX1BP3(1), UBE2D2(1), UBE2D3(1), UBE2E1(1), UBE2J1(1), UBE2J2(1), UBE2L3(2), UBE2L6(2), UBE2M(2), UBE2S(1), UBE3A(6)	7230778	23	21	23	8	3	10	6	0	4	0	0.525	1.000	1.000
132	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNG(2), IL12A(1), IL12B(4), IL13(1), IL16(12), IL18(1), IL1A(1), IL2(2), IL3(1), IL4(1), IL5(2), IL6(2), IL9(2), LTA(4)	7559330	36	34	36	11	7	9	10	6	4	0	0.372	1.000	1.000
133	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	5	CREBBP(39), ESR1(6), PELP1(2)	6952436	47	40	46	14	5	7	14	9	11	1	0.346	1.000	1.000
134	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(2), GNAS(12), GNB1(3), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PRKCA(7)	7309401	40	35	40	10	14	9	9	4	4	0	0.184	1.000	1.000
135	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	11	APC(27), CDH1(5), CREBBP(39), MAP2K1(5), MAP3K7(8), SKIL(3), TGFB1(1), TGFB2(3), TGFB3(1), TGFBR1(2)	14883936	94	72	91	20	11	15	28	20	19	1	0.157	1.000	1.000
136	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(16), GNA12(1), PRKACB(3), PRKACG(3), PRKAR2B(3)	7645574	26	24	26	8	4	10	6	3	3	0	0.441	1.000	1.000
137	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(3), CDC25A(2), CDC25B(4), CDC25C(4), CSK(1), PRKCA(7), PTPRA(4)	6989177	25	24	25	8	6	7	6	2	4	0	0.397	1.000	1.000
138	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(4), HK1(4), HK2(5), HK3(8), IMPA1(2), IMPA2(4), ISYNA1(4), PGM1(5), PGM3(1), TGDS(3)	8868988	40	38	40	10	9	10	10	3	8	0	0.0806	1.000	1.000
139	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(6), APOBEC1(1), APOBEC2(1), APOBEC3B(5), APOBEC3C(1), APOBEC3G(1)	5573878	15	15	15	7	2	2	6	4	1	0	0.881	1.000	1.000
140	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(1), B3GALNT1(1), B3GALT5(1), FUT2(2), FUT9(11), GBGT1(4), GLA(3), HEXA(4), NAGA(5), ST3GAL1(2), ST3GAL2(1), ST8SIA1(3)	8183514	38	35	38	11	7	7	15	4	5	0	0.223	1.000	1.000
141	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	12	AKT1(2), BAD(1), IGF1R(13), IRS1(4), MAP2K1(5), PIK3R1(10), RAF1(3), SHC1(3), SOS1(9), YWHAH(2)	11923445	52	45	52	11	10	12	15	8	7	0	0.0759	1.000	1.000
142	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CCL2(2), CSF1(2), IL1B(1), MST1R(8)	4955041	13	13	13	9	1	4	7	0	1	0	0.919	1.000	1.000
143	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	11	ASAH1(1), BRAF(10), CREB1(1), CREB5(8), RAF1(3), SNX13(2)	7952573	25	19	25	8	2	4	8	6	5	0	0.629	1.000	1.000
144	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	17	AKT1(2), BAD(1), BCL2L1(2), CASP9(1), CDC42(3), CHUK(6), ELK1(2), H2AFX(1), MAP2K1(5), NFKB1(5), PIK3R1(10), RAF1(3), RALBP1(5), RALGDS(6), RELA(2)	11885461	54	46	54	12	10	9	17	4	14	0	0.154	1.000	1.000
145	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	18	ADCY1(21), ARHGEF1(9), F2(3), F2R(4), F2RL3(3), GNA12(1), GNA13(2), GNAI1(2), GNB1(3), MAP3K7(8), PIK3R1(10), PLCB1(21), PPP1R12B(4), PRKCA(7), PTK2B(4), ROCK1(19)	18014302	121	97	118	27	20	23	40	22	16	0	0.0205	1.000	1.000
146	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	16	AKT1(2), ANXA1(2), CALM1(1), CALM2(2), CALM3(2), GNAS(12), GNB1(3), NFKB1(5), NOS3(4), NPPA(3), NR3C1(6), PIK3R1(10), RELA(2), SYT1(8)	11981750	62	50	62	13	13	12	14	12	11	0	0.111	1.000	1.000
147	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA1(2), ANXA3(2), ANXA4(2), ANXA6(7), CYP11A1(3), EDN1(1), EDNRA(2), EDNRB(7), HPGD(1), HSD11B2(3), PLA2G4A(3), PRL(4), PTGDR(3), PTGDS(2), PTGER2(5), PTGER4(6), PTGFR(2), PTGIR(2), PTGIS(7), PTGS1(7), PTGS2(4), TBXAS1(5)	15681651	80	68	79	20	18	13	16	12	20	1	0.0720	1.000	1.000
148	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	12	CCNA1(7), CCNA2(4), CCND1(4), CCNE1(5), CCNE2(4), CDK4(5), CDKN1B(2), E2F2(3), E2F4(2), PRB1(8)	6397211	44	42	44	14	1	12	12	12	7	0	0.593	1.000	1.000
149	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	19	F2(3), F2R(4), F2RL3(3), GNAI1(2), GNB1(3), ITGA1(4), ITGB1(16), MAP2K1(5), PLA2G4A(3), PLCB1(21), PRKCA(7), PTGS1(7), PTK2(8), RAF1(3), SYK(8), TBXAS1(5)	17698435	102	83	100	23	15	17	32	19	19	0	0.0426	1.000	1.000
150	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	12	C1QA(3), C1R(4), C1S(6), C2(6), C3(16), C5(11), C7(12), C8A(8), C8B(9), C9(15), MASP1(7)	14372980	97	76	95	24	14	29	30	16	8	0	0.0456	1.000	1.000
151	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(2), ALAS2(5), CPOX(1), FECH(1), PPOX(1), UROD(1), UROS(4)	5738999	15	15	15	7	1	3	5	5	1	0	0.846	1.000	1.000
152	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM1(1), CALM2(2), CALM3(2), CAMK1(2), CAMK1G(2), CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), CAMKK1(1), CAMKK2(6), CREB1(1), SYT1(8)	8786689	36	36	36	10	4	7	13	8	4	0	0.410	1.000	1.000
153	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	CISH(1), IL6(2), IL6R(5), JAK1(11), JAK2(5), JAK3(6), PIAS3(4), PTPRU(9), REG1A(13), STAT3(6)	11553078	62	58	62	16	11	11	20	12	8	0	0.125	1.000	1.000
154	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(3), LDLR(5), MBTPS1(10), MBTPS2(4), SCAP(9), SREBF1(5), SREBF2(5)	9048536	41	39	40	12	6	8	13	9	5	0	0.362	1.000	1.000
155	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	12	CARM1(5), CREB1(1), CREBBP(39), NCOA3(8), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), RARA(4), RXRA(5)	11954119	78	65	77	22	15	19	16	12	15	1	0.189	1.000	1.000
156	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	19	CSNK2A1(7), FOS(6), JAK2(5), JUN(1), MAP2K1(5), MPL(4), PIK3R1(10), PLCG1(8), PRKCA(7), RAF1(3), SHC1(3), SOS1(9), STAT1(7), STAT3(6), STAT5A(3), STAT5B(5), THPO(1)	19237986	90	75	90	19	14	22	27	10	17	0	0.0217	1.000	1.000
157	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	CARM1(5), DHRS1(2), DHRS2(4), DHRS3(1), DHRS7(1), HEMK1(1), LCMT1(2), LCMT2(7), METTL2B(4), METTL6(3), PRMT2(1), PRMT3(6), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(4)	11404505	49	45	49	13	10	13	11	8	7	0	0.143	1.000	1.000
158	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	7	CREB1(1), PTK2B(4), SHC1(3), SOS1(9)	6371114	17	16	17	7	7	2	4	3	1	0	0.710	1.000	1.000
159	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	14	APAF1(12), BIRC2(2), BIRC3(2), CASP10(2), CASP3(2), CASP7(3), CASP9(1), GZMB(2), PRF1(4), SCAP(9), SREBF1(5), SREBF2(5)	12953721	49	44	49	11	10	11	10	9	9	0	0.113	1.000	1.000
160	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	13	AKT1(2), BCAR1(3), CDKN1B(2), ILK(4), ITGB1(16), PDK2(1), PDPK1(4), PIK3R1(10), PTK2(8), SHC1(3), SOS1(9)	11921381	62	52	60	16	9	12	15	8	18	0	0.296	1.000	1.000
161	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5(3), CDK5R1(1), DAB1(8), FYN(5), LRP8(4), RELN(53), VLDLR(5)	10640095	79	65	79	23	14	16	19	16	14	0	0.233	1.000	1.000
162	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(4), F2(3), F2R(4), F3(2), F5(20), F7(3), FGA(10), FGB(4), FGG(6), PROC(2), PROS1(9), SERPINC1(4), TFPI(2)	12450168	73	58	73	19	6	23	21	13	10	0	0.158	1.000	1.000
163	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(5), ANKRD1(1), CYR61(2), DUSP14(4), EIF4E(1), EIF4EBP1(1), IFNG(2), IFRD1(5), IL18(1), IL1A(1), IL1R1(4), JUND(1), MYOG(3), NR4A3(3), WDR1(4)	8140743	38	34	38	11	5	7	9	12	5	0	0.513	1.000	1.000
164	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(4), POLR2A(11), POLR2B(10), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(3), POLR2G(4), POLR2H(1), POLR2I(1), POLR2J(2), POLR2L(2), POLRMT(6)	10251772	47	40	47	11	3	9	18	6	11	0	0.193	1.000	1.000
165	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(5), ENO1(2), GPI(3), HK1(4), PFKL(6), PGAM1(2), PGK1(2), PKLR(3), TPI1(4)	7051136	31	30	31	10	7	8	5	4	7	0	0.355	1.000	1.000
166	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(4), FARSA(1), FARSB(7), GOT1(1), GOT2(3), PAH(7), TAT(1), YARS(7), YARS2(4)	6612485	35	32	35	10	2	11	12	5	5	0	0.260	1.000	1.000
167	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	11	ADAM17(5), APC(27), AXIN1(11), BTRC(1), CTNNB1(6), DLL1(5), DVL1(7), FZD1(6), GSK3B(3), WNT1(2)	13236379	73	53	72	19	13	18	16	13	12	1	0.154	1.000	1.000
168	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(1), JAK1(11), JAK2(5), JAK3(6), PIAS1(1), PIAS3(4), PTPRU(9), REG1A(13), SOAT1(5)	10403694	55	51	55	15	10	10	17	9	9	0	0.246	1.000	1.000
169	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(9), EGFR(19), MAP2K1(5), MAP3K1(6), MAPK14(2), NCOR2(24), RARA(4), RXRA(5), THRA(6), THRB(1)	13131412	81	68	81	22	13	13	24	16	14	1	0.179	1.000	1.000
170	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	14	BCL2(1), CREBBP(39), FYN(5), IL7(1), IL7R(6), JAK1(11), JAK3(6), LCK(5), NMI(6), PIK3R1(10), PTK2B(4), STAT5A(3), STAT5B(5)	15834955	102	78	101	27	10	22	24	21	24	1	0.0570	1.000	1.000
171	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	21	CSNK2A1(7), ELK1(2), FOS(6), IL2(2), IL2RA(2), IL2RB(3), JAK1(11), JAK3(6), JUN(1), LCK(5), MAP2K1(5), MAPK8(4), RAF1(3), SHC1(3), SOS1(9), STAT5A(3), STAT5B(5), SYK(8)	17382445	85	72	85	21	11	18	28	11	17	0	0.0443	1.000	1.000
172	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	14	CSF2RB(8), FOS(6), IL3(1), IL3RA(6), JAK2(5), MAP2K1(5), PTPN6(2), RAF1(3), SHC1(3), SOS1(9), STAT5A(3), STAT5B(5)	13118426	56	49	56	15	9	16	17	8	6	0	0.113	1.000	1.000
173	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	10	AKT1(2), KLK2(2), NTRK1(3), PIK3R1(10), PLCG1(8), PRKCA(7), SHC1(3), SOS1(9)	9840505	44	40	44	12	7	10	14	7	6	0	0.350	1.000	1.000
174	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	23	ABL1(8), ATM(16), ATR(25), CCNA1(7), CCND1(4), CCNE1(5), CDC25A(2), CDK4(5), CDK6(2), CDKN1B(2), DHFR(3), GSK3B(3), HDAC1(1), RB1(18), SKP2(4), TFDP1(2), TGFB1(1), TGFB2(3), TGFB3(1)	21884065	112	97	111	26	9	22	27	24	30	0	0.142	1.000	1.000
175	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	14	CHUK(6), CREBBP(39), FADD(4), HDAC3(3), IKBKB(12), NFKB1(5), NFKBIA(1), RELA(2), RIPK1(2), TNFRSF1A(1), TNFRSF1B(2), TRADD(1), TRAF6(3)	13310411	81	72	80	22	12	15	24	15	14	1	0.169	1.000	1.000
176	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	22	CALM1(1), CALM2(2), CALM3(2), CAMK1(2), CAMK1G(2), CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), ESRRA(5), HDAC5(3), MEF2A(3), MEF2B(5), MEF2D(1), PPARA(2), PPP3CA(2), PPP3CB(1), SLC2A4(3), SYT1(8), YWHAH(2)	14716358	55	49	54	14	5	15	18	14	3	0	0.121	1.000	1.000
177	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	20	ACTA1(4), ADCY1(21), CAP1(3), CCNB1(3), CDC25C(4), GNAI1(2), GNAS(12), GNB1(3), MYT1(12), PIN1(1), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), RPS6KA1(10)	14810434	91	72	90	22	27	18	24	12	10	0	0.0325	1.000	1.000
178	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	21	CCNA1(7), CCNB1(3), CCND1(4), CCND2(2), CCNE1(5), CDC25A(2), CDK4(5), CDK6(2), CDKN1B(2), CDKN2C(1), RB1(18), RBL1(11), TFDP1(2)	11744055	64	58	64	18	4	14	12	11	23	0	0.312	1.000	1.000
179	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(3), ALOX15B(5), ALOX5(5), DPEP1(4), GGT1(4), LTA4H(1), PLA2G2A(2), PLA2G6(3), PTGDS(2), PTGIS(7), PTGS1(7), PTGS2(4), TBXAS1(5)	11454795	52	49	52	15	10	10	15	4	13	0	0.0998	1.000	1.000
180	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	24	APC(27), ASAH1(1), CASP3(2), CERK(3), CREB1(1), CREB5(8), CXCL2(1), DAG1(5), EPHB2(3), FOS(6), ITPKB(5), JUN(1), MAP2K4(2), MAP2K7(2), MAPK10(4), MAPK8(4), MAPK8IP1(3), MAPK8IP2(3), MAPK8IP3(8), MAPK9(4)	21252265	93	77	92	21	13	24	24	15	17	0	0.0458	1.000	1.000
181	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	23	CSNK2A1(7), ELK1(2), FOS(6), JAK1(11), JUN(1), MAP2K1(5), MAP2K4(2), MAP3K1(6), MAPK8(4), PDGFRA(14), PIK3R1(10), PLCG1(8), PRKCA(7), RAF1(3), SHC1(3), SOS1(9), SRF(1), STAT1(7), STAT3(6), STAT5A(3)	22979223	115	95	115	27	17	26	35	14	23	0	0.0409	1.000	1.000
182	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(4), APAF1(12), BCL2(1), CASP3(2), CASP9(1), DAXX(5), FAS(5), FASLG(1), HSPB2(2), IL1A(1), MAPKAPK3(4)	8603698	38	35	38	12	6	11	10	6	5	0	0.430	1.000	1.000
183	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	185	ACTB(5), ACTG1(3), ACTN1(4), ACTN2(11), ACTN4(6), AKT1(2), AKT2(3), AKT3(6), ARHGAP5(10), BAD(1), BCAR1(3), BCL2(1), BIRC2(2), BIRC3(2), BRAF(10), CAPN2(6), CAV1(1), CCND1(4), CCND2(2), CDC42(3), CHAD(5), COL11A1(65), COL11A2(11), COL1A1(10), COL1A2(21), COL2A1(6), COL3A1(18), COL4A1(10), COL4A2(9), COL4A4(14), COL4A6(4), COL5A1(18), COL5A2(15), COL5A3(11), COL6A1(10), COL6A2(12), COL6A3(27), COL6A6(30), CRK(2), CRKL(3), CTNNB1(6), DIAPH1(7), DOCK1(15), EGF(9), EGFR(19), ELK1(2), ERBB2(11), FARP2(3), FIGF(1), FLNA(23), FLNB(10), FLNC(15), FLT1(17), FN1(19), FYN(5), GSK3B(3), HGF(12), IBSP(3), IGF1(1), IGF1R(13), ILK(4), ITGA1(4), ITGA10(9), ITGA11(10), ITGA2(7), ITGA2B(6), ITGA3(5), ITGA4(13), ITGA5(4), ITGA6(4), ITGA7(8), ITGA9(3), ITGAV(6), ITGB1(16), ITGB3(6), ITGB4(8), ITGB5(1), ITGB6(6), ITGB7(1), ITGB8(5), JUN(1), KDR(13), LAMA1(33), LAMA2(46), LAMA3(19), LAMA4(25), LAMA5(17), LAMB1(9), LAMB2(6), LAMB3(5), LAMB4(18), LAMC1(13), LAMC2(5), LAMC3(9), MAP2K1(5), MAPK10(4), MAPK8(4), MAPK9(4), MET(4), MYL7(2), MYL9(4), MYLK(8), MYLK2(5), PAK1(3), PAK2(8), PAK3(4), PAK4(1), PAK6(5), PAK7(9), PARVB(1), PARVG(2), PDGFB(1), PDGFC(3), PDGFD(6), PDGFRA(14), PDGFRB(8), PDPK1(4), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PIP5K1C(2), PPP1CA(1), PPP1R12A(5), PRKCA(7), PRKCG(12), PTK2(8), PXN(2), RAC2(2), RAC3(3), RAF1(3), RAP1B(3), RAPGEF1(5), RELN(53), ROCK1(19), ROCK2(10), SHC1(3), SHC2(5), SHC3(6), SHC4(4), SOS1(9), SOS2(11), SPP1(2), THBS1(8), THBS2(11), THBS3(4), THBS4(7), TLN1(24), TLN2(13), TNC(12), TNN(23), TNR(19), TNXB(23), VASP(1), VAV1(8), VAV2(4), VAV3(4), VCL(6), VEGFB(1), VEGFC(6), VTN(2), VWF(19), ZYX(2)	277078767	1472	415	1459	477	232	319	465	223	227	6	0.0790	1.000	1.000
184	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	167	ADCY1(21), ADCY2(29), ADCY3(8), ADCY4(8), ADCY7(5), ADCY8(28), ADCY9(9), ADORA2A(2), ADORA2B(1), ADRA1A(5), ADRA1B(3), ADRA1D(3), ADRB1(3), ADRB3(2), ATP2A1(8), ATP2A2(7), ATP2A3(6), ATP2B1(7), ATP2B2(6), ATP2B3(15), ATP2B4(6), AVPR1A(9), AVPR1B(7), BDKRB1(3), BDKRB2(3), BST1(2), CACNA1A(14), CACNA1B(13), CACNA1C(23), CACNA1D(21), CACNA1E(24), CACNA1F(11), CACNA1G(19), CACNA1H(13), CACNA1I(12), CACNA1S(16), CALM1(1), CALM2(2), CALM3(2), CALML3(1), CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), CCKAR(5), CCKBR(5), CD38(5), CHRM2(5), CHRM3(9), CHRM5(3), CHRNA7(2), CYSLTR1(2), CYSLTR2(5), DRD1(2), EDNRA(2), EDNRB(7), EGFR(19), ERBB2(11), ERBB3(14), ERBB4(21), F2R(4), GNA11(4), GNA14(3), GNA15(4), GNAL(4), GNAS(12), GRIN1(4), GRIN2A(21), GRIN2C(7), GRIN2D(6), GRM1(29), GRM5(12), GRPR(1), HRH1(1), HRH2(3), HTR2A(5), HTR2B(2), HTR2C(3), HTR4(2), HTR5A(8), HTR6(6), HTR7(7), ITPKB(5), ITPR1(16), ITPR2(25), ITPR3(10), LHCGR(9), LTB4R2(3), MYLK(8), MYLK2(5), NOS1(9), NOS3(4), NTSR1(3), OXTR(2), P2RX1(4), P2RX2(3), P2RX3(4), P2RX4(3), P2RX5(2), P2RX7(1), PDE1A(6), PDE1B(4), PDE1C(14), PDGFRA(14), PDGFRB(8), PHKA1(4), PHKA2(9), PHKB(3), PHKG1(3), PHKG2(2), PLCB1(21), PLCB2(7), PLCB3(8), PLCB4(17), PLCD1(4), PLCD3(2), PLCD4(2), PLCE1(21), PLCG1(8), PLCG2(9), PLCZ1(7), PPP3CA(2), PPP3CB(1), PRKACA(4), PRKACB(3), PRKACG(3), PRKCA(7), PRKCG(12), PRKX(1), PTGER3(6), PTGFR(2), PTK2B(4), RYR1(34), RYR2(79), RYR3(37), SLC25A6(4), SLC8A1(14), SLC8A2(6), SLC8A3(16), SPHK2(3), TACR1(3), TACR2(4), TACR3(6), TBXA2R(1), TNNC2(1), TRHR(7), TRPC1(10)	204129430	1213	394	1206	427	255	255	350	199	153	1	0.0132	1.000	1.000
185	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	240	ACVR1B(5), ACVR1C(8), AKT1(2), AKT2(3), AKT3(6), ARRB1(2), ARRB2(1), ATF2(1), ATF4(5), BDNF(2), BRAF(10), CACNA1A(14), CACNA1B(13), CACNA1C(23), CACNA1D(21), CACNA1E(24), CACNA1F(11), CACNA1G(19), CACNA1H(13), CACNA1I(12), CACNA1S(16), CACNA2D1(21), CACNA2D2(3), CACNA2D3(2), CACNA2D4(7), CACNB1(5), CACNB2(6), CACNB3(3), CACNB4(2), CACNG1(1), CACNG2(3), CACNG3(3), CACNG4(7), CACNG5(4), CACNG6(5), CACNG7(4), CACNG8(8), CASP3(2), CD14(1), CDC25B(4), CDC42(3), CHUK(6), CRK(2), CRKL(3), DAXX(5), DUSP1(2), DUSP10(3), DUSP14(4), DUSP16(6), DUSP2(1), DUSP3(1), DUSP4(1), DUSP5(4), DUSP6(5), DUSP7(3), DUSP8(1), DUSP9(1), ECSIT(4), EGF(9), EGFR(19), ELK1(2), ELK4(4), FAS(5), FASLG(1), FGF1(2), FGF10(2), FGF11(1), FGF12(5), FGF13(3), FGF14(1), FGF17(2), FGF19(3), FGF2(1), FGF20(1), FGF21(1), FGF23(8), FGF3(1), FGF5(3), FGF6(1), FGF7(1), FGF8(2), FGF9(1), FGFR1(2), FGFR2(3), FGFR3(15), FGFR4(5), FLNA(23), FLNB(10), FLNC(15), FOS(6), GADD45A(1), GADD45G(1), GNA12(1), GNG12(1), IKBKB(12), IL1A(1), IL1B(1), IL1R1(4), IL1R2(1), JUN(1), JUND(1), KRAS(1), MAP2K1(5), MAP2K2(6), MAP2K3(4), MAP2K4(2), MAP2K5(3), MAP2K6(1), MAP2K7(2), MAP3K1(6), MAP3K10(6), MAP3K12(8), MAP3K13(15), MAP3K2(1), MAP3K3(3), MAP3K4(14), MAP3K5(6), MAP3K6(6), MAP3K7(8), MAP3K8(4), MAP4K1(4), MAP4K2(2), MAP4K3(7), MAP4K4(4), MAPK10(4), MAPK11(3), MAPK12(3), MAPK13(3), MAPK14(2), MAPK7(6), MAPK8(4), MAPK8IP1(3), MAPK8IP2(3), MAPK8IP3(8), MAPK9(4), MAPKAPK3(4), MAPKAPK5(2), MAPT(8), MAX(1), MKNK1(1), MKNK2(2), MOS(7), MYC(6), NF1(16), NFATC2(15), NFATC4(3), NFKB1(5), NFKB2(5), NLK(1), NR4A1(2), NRAS(1), NTF3(1), NTRK1(3), NTRK2(3), PAK1(3), PAK2(8), PDGFB(1), PDGFRA(14), PDGFRB(8), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PPM1A(4), PPM1B(2), PPP3CA(2), PPP3CB(1), PPP5C(4), PRKACA(4), PRKACB(3), PRKACG(3), PRKCA(7), PRKCG(12), PRKX(1), PTPN5(1), PTPN7(4), PTPRR(5), RAC2(2), RAC3(3), RAF1(3), RAP1B(3), RAPGEF2(4), RASA2(8), RASGRF1(16), RASGRF2(12), RASGRP1(8), RASGRP2(6), RASGRP3(8), RASGRP4(3), RPS6KA1(10), RPS6KA2(6), RPS6KA3(4), RPS6KA4(3), RPS6KA5(5), RPS6KA6(8), RRAS(2), RRAS2(1), SOS1(9), SOS2(11), SRF(1), STK3(3), STK4(1), TAOK1(6), TAOK2(13), TAOK3(5), TGFB1(1), TGFB2(3), TGFB3(1), TGFBR1(2), TNFRSF1A(1), TRAF2(2), TRAF6(3), ZAK(5)	212444297	1073	389	1062	363	210	227	317	157	160	2	0.0595	1.000	1.000
186	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	234	ADCYAP1R1(7), ADORA1(4), ADORA2A(2), ADORA2B(1), ADORA3(3), ADRA1A(5), ADRA1B(3), ADRA2B(4), ADRA2C(3), ADRB1(3), ADRB3(2), AGTR2(2), AVPR1A(9), AVPR1B(7), AVPR2(2), BDKRB1(3), BDKRB2(3), BRS3(3), C3AR1(5), C5AR1(2), CALCR(4), CALCRL(5), CCKAR(5), CCKBR(5), CGA(1), CHRM2(5), CHRM3(9), CHRM4(2), CHRM5(3), CNR1(4), CRHR1(3), CRHR2(4), CTSG(1), CYSLTR1(2), CYSLTR2(5), DRD1(2), DRD2(4), DRD3(6), DRD4(1), DRD5(8), EDNRA(2), EDNRB(7), F2(3), F2R(4), F2RL1(1), F2RL2(2), F2RL3(3), FPR1(7), FSHB(2), FSHR(12), GABBR1(3), GABBR2(6), GABRA1(11), GABRA2(13), GABRA3(7), GABRA4(5), GABRA5(6), GABRA6(6), GABRB1(8), GABRB2(8), GABRB3(14), GABRD(2), GABRE(8), GABRG1(10), GABRG2(8), GABRG3(7), GABRP(6), GABRQ(10), GABRR1(4), GABRR2(3), GALR1(4), GALR2(4), GALR3(2), GH1(4), GH2(4), GHR(8), GHRHR(4), GHSR(3), GIPR(2), GLP1R(2), GLP2R(3), GLRA1(3), GLRA2(5), GLRA3(4), GLRB(4), GNRHR(2), GPR156(5), GPR35(2), GPR50(6), GPR63(6), GPR83(1), GRIA1(17), GRIA2(16), GRIA3(8), GRIA4(11), GRID1(20), GRID2(21), GRIK1(8), GRIK2(15), GRIK3(8), GRIK4(6), GRIK5(9), GRIN1(4), GRIN2A(21), GRIN2B(23), GRIN2C(7), GRIN2D(6), GRIN3A(17), GRIN3B(5), GRM1(29), GRM2(10), GRM3(29), GRM4(2), GRM5(12), GRM6(4), GRM7(19), GRM8(23), GRPR(1), GZMA(2), HCRTR1(3), HCRTR2(7), HRH1(1), HRH2(3), HRH3(3), HRH4(3), HTR1A(9), HTR1B(7), HTR1D(2), HTR1E(8), HTR1F(4), HTR2A(5), HTR2B(2), HTR2C(3), HTR4(2), HTR5A(8), HTR6(6), HTR7(7), LEP(1), LEPR(20), LHB(2), LHCGR(9), LTB4R(3), LTB4R2(3), MAS1(2), MC1R(2), MC2R(7), MC3R(4), MC4R(4), MC5R(9), MCHR1(3), MCHR2(5), MLNR(4), MTNR1A(3), MTNR1B(3), NMBR(3), NMUR1(5), NMUR2(1), NPBWR1(1), NPBWR2(4), NPY1R(6), NPY2R(5), NPY5R(8), NR3C1(6), NTSR1(3), NTSR2(6), OPRD1(2), OPRK1(7), OPRL1(6), OPRM1(4), OXTR(2), P2RX1(4), P2RX2(3), P2RX3(4), P2RX4(3), P2RX5(2), P2RX7(1), P2RY1(5), P2RY10(5), P2RY11(3), P2RY13(3), P2RY14(1), P2RY2(3), P2RY6(2), P2RY8(3), PARD3(15), PRL(4), PRLHR(5), PRLR(8), PRSS1(10), PRSS3(1), PTGDR(3), PTGER2(5), PTGER3(6), PTGER4(6), PTGFR(2), PTGIR(2), PTH2R(12), RXFP1(5), RXFP2(9), SCTR(2), SSTR1(8), SSTR2(3), SSTR3(6), SSTR4(7), SSTR5(2), TAAR1(5), TAAR2(2), TAAR5(1), TAAR6(1), TAAR8(1), TACR1(3), TACR2(4), TACR3(6), TBXA2R(1), THRA(6), THRB(1), TRHR(7), TRPV1(7), TSHB(2), TSHR(4), UTS2R(3), VIPR1(1), VIPR2(6)	167401304	1231	388	1224	441	220	229	419	203	159	1	0.0367	1.000	1.000
187	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	197	ABI2(3), ACTN1(4), ACTN2(11), ACTN4(6), APC(27), APC2(6), ARAF(2), ARHGEF1(9), ARHGEF12(12), ARHGEF4(5), ARHGEF6(7), ARHGEF7(2), ARPC1B(3), ARPC2(2), ARPC3(1), ARPC4(1), BAIAP2(2), BCAR1(3), BDKRB1(3), BDKRB2(3), BRAF(10), CD14(1), CDC42(3), CFL1(2), CHRM2(5), CHRM3(9), CHRM4(2), CHRM5(3), CRK(2), CRKL(3), CSK(1), CYFIP1(9), CYFIP2(9), DIAPH1(7), DIAPH2(10), DIAPH3(12), DOCK1(15), EGF(9), EGFR(19), F2(3), F2R(4), FGD1(12), FGD3(5), FGF1(2), FGF10(2), FGF11(1), FGF12(5), FGF13(3), FGF14(1), FGF17(2), FGF19(3), FGF2(1), FGF20(1), FGF21(1), FGF23(8), FGF3(1), FGF5(3), FGF6(1), FGF7(1), FGF8(2), FGF9(1), FGFR1(2), FGFR2(3), FGFR3(15), FGFR4(5), FN1(19), GIT1(5), GNA12(1), GNA13(2), GNG12(1), GSN(5), IQGAP1(11), IQGAP2(6), IQGAP3(10), ITGA1(4), ITGA10(9), ITGA11(10), ITGA2(7), ITGA2B(6), ITGA3(5), ITGA4(13), ITGA5(4), ITGA6(4), ITGA7(8), ITGA9(3), ITGAD(7), ITGAE(4), ITGAL(7), ITGAM(8), ITGAV(6), ITGAX(7), ITGB1(16), ITGB2(4), ITGB3(6), ITGB4(8), ITGB5(1), ITGB6(6), ITGB7(1), ITGB8(5), KRAS(1), LIMK1(5), LIMK2(6), MAP2K1(5), MAP2K2(6), MOS(7), MSN(3), MYH10(24), MYH14(7), MYH9(24), MYL7(2), MYL9(4), MYLK(8), MYLK2(5), NCKAP1(8), NCKAP1L(8), NRAS(1), PAK1(3), PAK2(8), PAK3(4), PAK4(1), PAK6(5), PAK7(9), PDGFB(1), PDGFRA(14), PDGFRB(8), PFN1(1), PFN4(1), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PIP4K2B(3), PIP4K2C(3), PIP5K1A(4), PIP5K1B(8), PIP5K1C(2), PPP1CA(1), PPP1R12A(5), PPP1R12B(4), PTK2(8), PXN(2), RAC2(2), RAC3(3), RAF1(3), RDX(1), ROCK1(19), ROCK2(10), RRAS(2), RRAS2(1), SCIN(5), SLC9A1(4), SOS1(9), SOS2(11), SSH1(7), SSH2(7), SSH3(5), TIAM1(15), TIAM2(13), TMSB4Y(1), VAV1(8), VAV2(4), VAV3(4), VCL(6), WAS(2), WASF1(3), WASF2(5), WASL(2)	205275484	987	368	975	347	184	201	285	159	156	2	0.473	1.000	1.000
188	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	136	ACTB(5), ACTG1(3), CHAD(5), COL11A1(65), COL11A2(11), COL17A1(11), COL1A1(10), COL1A2(21), COL2A1(6), COL3A1(18), COL4A1(10), COL4A2(9), COL4A4(14), COL4A6(4), COL5A1(18), COL5A2(15), COL5A3(11), COL6A1(10), COL6A2(12), COL6A3(27), COL6A6(30), DES(3), DSC1(4), DSC2(8), DSC3(1), DSG1(9), DSG2(3), DSG3(2), DSG4(5), FN1(19), GJA1(2), GJA10(7), GJA3(2), GJA4(1), GJA5(6), GJA8(8), GJA9(2), GJB3(1), GJB4(2), GJB7(1), GJC1(4), GJC3(2), GJD2(2), IBSP(3), ITGA6(4), ITGB4(8), KRT1(2), KRT10(5), KRT12(8), KRT13(4), KRT14(11), KRT15(2), KRT16(2), KRT18(1), KRT19(1), KRT2(3), KRT20(1), KRT23(4), KRT24(6), KRT25(6), KRT27(3), KRT28(6), KRT3(5), KRT31(3), KRT32(2), KRT33A(4), KRT33B(4), KRT34(4), KRT35(4), KRT36(6), KRT37(2), KRT38(5), KRT39(5), KRT4(6), KRT40(5), KRT5(11), KRT6A(4), KRT6B(2), KRT6C(3), KRT7(2), KRT71(3), KRT72(4), KRT73(4), KRT74(7), KRT75(5), KRT76(3), KRT77(3), KRT78(8), KRT79(4), KRT8(1), KRT82(7), KRT83(6), KRT84(1), KRT85(5), KRT86(4), KRT9(3), LAMA1(33), LAMA2(46), LAMA3(19), LAMA4(25), LAMA5(17), LAMB1(9), LAMB2(6), LAMB3(5), LAMB4(18), LAMC1(13), LAMC2(5), LAMC3(9), LMNA(1), LMNB1(1), LMNB2(8), NES(13), RELN(53), SPP1(2), THBS1(8), THBS2(11), THBS3(4), THBS4(7), TNC(12), TNN(23), TNR(19), TNXB(23), VIM(4), VTN(2), VWF(19)	189768350	1049	361	1043	361	175	214	353	148	154	5	0.356	1.000	1.000
189	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	121	ABL1(8), ABLIM1(7), ABLIM2(5), ABLIM3(5), ARHGEF12(12), CDC42(3), CDK5(3), CFL1(2), CXCL12(3), CXCR4(2), DCC(31), DPYSL2(5), DPYSL5(5), EFNA1(2), EFNA3(1), EFNA5(3), EFNB1(4), EFNB2(1), EFNB3(3), EPHA1(8), EPHA3(19), EPHA4(11), EPHA5(25), EPHA6(18), EPHA7(24), EPHA8(5), EPHB1(16), EPHB2(3), EPHB3(9), EPHB4(8), EPHB6(7), FES(6), FYN(5), GNAI1(2), GNAI2(1), GNAI3(1), GSK3B(3), ITGB1(16), KRAS(1), L1CAM(10), LIMK1(5), LIMK2(6), LRRC4C(29), MET(4), NCK1(5), NCK2(7), NFAT5(13), NFATC1(9), NFATC2(15), NFATC3(6), NFATC4(3), NGEF(3), NRAS(1), NRP1(6), NTN1(3), NTN4(2), NTNG1(3), PAK1(3), PAK2(8), PAK3(4), PAK4(1), PAK6(5), PAK7(9), PLXNA1(24), PLXNA2(17), PLXNA3(15), PLXNB1(7), PLXNB2(17), PLXNB3(9), PLXNC1(9), PPP3CA(2), PPP3CB(1), PTK2(8), RAC2(2), RAC3(3), RGS3(10), RHOD(1), ROBO1(12), ROBO2(16), ROBO3(6), ROCK1(19), ROCK2(10), SEMA3A(14), SEMA3C(8), SEMA3D(5), SEMA3E(12), SEMA3F(4), SEMA3G(4), SEMA4A(5), SEMA4B(1), SEMA4C(3), SEMA4D(8), SEMA4F(5), SEMA4G(8), SEMA5A(28), SEMA5B(13), SEMA6A(3), SEMA6B(6), SEMA6C(1), SEMA6D(11), SEMA7A(4), SLIT1(10), SLIT2(25), SLIT3(9), SRGAP1(11), SRGAP2(2), SRGAP3(7), UNC5A(5), UNC5B(8), UNC5C(20), UNC5D(20)	145350891	901	356	894	279	138	181	284	152	144	2	0.0133	1.000	1.000
190	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	84	AGRN(9), CD36(2), CD44(3), CD47(1), CHAD(5), COL11A1(65), COL11A2(11), COL1A1(10), COL1A2(21), COL2A1(6), COL3A1(18), COL4A1(10), COL4A2(9), COL4A4(14), COL4A6(4), COL5A1(18), COL5A2(15), COL5A3(11), COL6A1(10), COL6A2(12), COL6A3(27), COL6A6(30), DAG1(5), FN1(19), FNDC1(13), FNDC3A(11), FNDC4(3), FNDC5(1), GP5(4), GP6(1), GP9(2), HMMR(2), HSPG2(23), IBSP(3), ITGA1(4), ITGA10(9), ITGA11(10), ITGA2(7), ITGA2B(6), ITGA3(5), ITGA4(13), ITGA5(4), ITGA6(4), ITGA7(8), ITGA9(3), ITGAV(6), ITGB1(16), ITGB3(6), ITGB4(8), ITGB5(1), ITGB6(6), ITGB7(1), ITGB8(5), LAMA1(33), LAMA2(46), LAMA3(19), LAMA4(25), LAMA5(17), LAMB1(9), LAMB2(6), LAMB3(5), LAMB4(18), LAMC1(13), LAMC2(5), LAMC3(9), RELN(53), SDC1(2), SDC2(2), SDC3(2), SDC4(1), SPP1(2), SV2A(5), SV2B(3), SV2C(4), THBS1(8), THBS2(11), THBS3(4), THBS4(7), TNC(12), TNN(23), TNR(19), TNXB(23), VTN(2), VWF(19)	169148130	927	347	921	316	150	201	292	139	141	4	0.383	1.000	1.000
191	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(21), ADCY2(29), ADCY3(8), ADCY4(8), ADCY5(10), ADCY6(6), ADCY7(5), ADCY8(28), ADCY9(9), ADRA1A(5), ADRA1B(3), ADRA1D(3), ADRB1(3), ADRB3(2), ANXA6(7), ARRB1(2), ARRB2(1), ATP1A4(5), ATP1B1(2), ATP1B2(2), ATP1B3(4), ATP2A2(7), ATP2A3(6), ATP2B1(7), ATP2B2(6), ATP2B3(15), CACNA1A(14), CACNA1B(13), CACNA1C(23), CACNA1D(21), CACNA1E(24), CACNA1S(16), CACNB1(5), CACNB3(3), CALM1(1), CALM2(2), CALM3(2), CALR(2), CAMK1(2), CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), CASQ1(3), CASQ2(4), CHRM2(5), CHRM3(9), CHRM4(2), CHRM5(3), GJA1(2), GJA4(1), GJA5(6), GJB3(1), GJB4(2), GNA11(4), GNAI2(1), GNAI3(1), GNAO1(1), GNAZ(7), GNB1(3), GNB2(4), GNB3(6), GNB4(2), GNB5(2), GNG12(1), GNG13(2), GNG2(1), GRK4(1), GRK5(6), ITPR1(16), ITPR2(25), ITPR3(10), KCNB1(3), KCNJ3(11), KCNJ5(3), MIB1(5), NME7(4), PEA15(1), PKIG(1), PLCB3(8), PRKACA(4), PRKACB(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PRKCA(7), PRKCD(4), PRKCE(3), PRKCG(12), PRKCH(4), PRKCQ(8), PRKCZ(3), PRKD1(15), RGS1(3), RGS11(2), RGS14(2), RGS16(1), RGS17(5), RGS18(4), RGS19(2), RGS2(1), RGS20(4), RGS3(10), RGS4(2), RGS5(3), RGS6(5), RGS7(17), RGS9(7), RYR1(34), RYR2(79), RYR3(37), SFN(7), SLC8A1(14), SLC8A3(16), USP5(5), YWHAB(2), YWHAH(2), YWHAQ(3)	142455442	850	345	845	305	179	190	233	136	110	2	0.0560	1.000	1.000
192	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	128	ACTB(5), ACTG1(3), ACTN1(4), ACTN2(11), ACTN4(6), AKT1(2), AKT2(3), AKT3(6), AMOTL1(5), ASH1L(20), CASK(4), CDC42(3), CDK4(5), CGN(5), CLDN10(4), CLDN11(1), CLDN15(3), CLDN16(6), CLDN17(3), CLDN18(3), CLDN2(2), CLDN22(2), CLDN23(1), CLDN4(1), CLDN6(2), CLDN7(1), CLDN8(1), CLDN9(1), CRB3(2), CSNK2A1(7), CSNK2A2(3), CSNK2B(2), CTNNA1(8), CTNNA2(29), CTNNA3(13), CTNNB1(6), CTTN(10), EPB41(4), EPB41L1(7), EPB41L2(12), EPB41L3(23), EXOC3(3), EXOC4(15), F11R(3), GNAI1(2), GNAI2(1), GNAI3(1), HCLS1(2), IGSF5(4), INADL(11), JAM2(2), KRAS(1), LLGL1(2), LLGL2(6), MAGI1(14), MAGI2(20), MAGI3(14), MLLT4(13), MPDZ(15), MPP5(7), MYH1(22), MYH10(24), MYH11(11), MYH13(28), MYH14(7), MYH15(14), MYH2(28), MYH3(14), MYH4(19), MYH6(20), MYH7(16), MYH7B(6), MYH8(26), MYH9(24), MYL7(2), MYL9(4), NRAS(1), OCLN(1), PARD3(15), PARD6A(1), PARD6B(1), PARD6G(6), PPP2CB(3), PPP2R1A(3), PPP2R1B(4), PPP2R2A(2), PPP2R2B(4), PPP2R2C(1), PPP2R3A(13), PPP2R3B(5), PPP2R4(2), PRKCA(7), PRKCD(4), PRKCE(3), PRKCG(12), PRKCH(4), PRKCI(3), PRKCQ(8), PRKCZ(3), RAB13(2), RRAS(2), RRAS2(1), SPTAN1(24), SYMPK(7), TJAP1(4), TJP1(12), TJP2(5), TJP3(6), VAPA(1), YES1(2), ZAK(5)	146368196	817	329	805	258	139	184	248	130	114	2	0.0358	1.000	1.000
193	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ACTA1(4), ACTA2(3), ADCY1(21), ADCY2(29), ADCY3(8), ADCY4(8), ADCY5(10), ADCY6(6), ADCY7(5), ADCY8(28), ADCY9(9), ADM(1), ARRB1(2), ARRB2(1), ATF1(3), ATF2(1), ATF4(5), ATF5(2), ATP2A2(7), ATP2A3(6), CACNB3(3), CALCA(1), CALM1(1), CALM2(2), CALM3(2), CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), CNN1(1), CNN2(1), CORIN(6), CRH(1), CRHR1(3), DGKZ(7), ETS2(7), FOS(6), GABPA(3), GABPB2(1), GBA2(6), GJA1(2), GNB1(3), GNB2(4), GNB3(6), GNB4(2), GNB5(2), GNG12(1), GNG13(2), GNG2(1), GRK4(1), GRK5(6), GSTO1(2), GUCA2A(1), GUCY1A3(9), IGFBP1(3), IGFBP2(1), IGFBP3(1), IGFBP4(1), IL1B(1), IL6(2), ITPR1(16), ITPR2(25), ITPR3(10), JUN(1), MIB1(5), MYL4(2), MYLK2(5), NFKB1(5), NOS1(9), NOS3(4), OXTR(2), PDE4B(7), PDE4D(7), PKIG(1), PLCB3(8), PLCD1(4), PLCG1(8), PLCG2(9), PRKACA(4), PRKACB(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PRKCA(7), PRKCD(4), PRKCE(3), PRKCH(4), PRKCQ(8), PRKCZ(3), PRKD1(15), RAMP1(1), RGS1(3), RGS11(2), RGS14(2), RGS16(1), RGS17(5), RGS18(4), RGS19(2), RGS2(1), RGS20(4), RGS3(10), RGS4(2), RGS5(3), RGS6(5), RGS7(17), RGS9(7), RYR1(34), RYR2(79), RYR3(37), SFN(7), SLC8A1(14), SP1(3), TNXB(23), USP5(5), YWHAB(2), YWHAH(2), YWHAQ(3)	131546288	739	329	736	261	141	176	207	118	95	2	0.101	1.000	1.000
194	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	249	ACVR1(5), ACVR1B(5), ACVR2A(1), ACVR2B(1), AMHR2(1), BMP2(5), BMP7(3), BMPR1B(4), BMPR2(6), CCL1(4), CCL15(1), CCL16(1), CCL2(2), CCL20(1), CCL23(3), CCL24(1), CCL25(3), CCL28(1), CCL3(1), CCL8(3), CCR1(1), CCR2(4), CCR3(6), CCR4(4), CCR6(2), CCR7(2), CCR9(2), CD27(3), CD40(7), CD40LG(5), CNTFR(1), CRLF2(4), CSF1(2), CSF1R(2), CSF2RA(1), CSF2RB(8), CSF3R(3), CX3CL1(3), CX3CR1(1), CXCL1(3), CXCL10(2), CXCL12(3), CXCL13(1), CXCL14(1), CXCL2(1), CXCL3(1), CXCL5(1), CXCL9(3), CXCR3(1), CXCR4(2), EDA(4), EDA2R(1), EDAR(2), EGF(9), EGFR(19), EPO(2), EPOR(2), FAS(5), FASLG(1), FLT1(17), FLT3(6), FLT3LG(1), FLT4(13), GDF5(4), GH1(4), GH2(4), GHR(8), HGF(12), IFNA10(1), IFNA14(1), IFNA16(4), IFNA17(3), IFNA2(1), IFNA21(2), IFNA4(4), IFNA6(1), IFNA8(3), IFNAR1(3), IFNAR2(2), IFNG(2), IFNGR1(4), IFNGR2(5), IFNK(1), IFNW1(2), IL10RA(5), IL10RB(2), IL11RA(2), IL12A(1), IL12B(4), IL12RB1(4), IL12RB2(11), IL13(1), IL13RA1(2), IL17A(3), IL17B(1), IL17RA(6), IL17RB(4), IL18(1), IL18R1(3), IL18RAP(6), IL19(4), IL1A(1), IL1B(1), IL1R1(4), IL1R2(1), IL1RAP(6), IL2(2), IL20RA(3), IL21(3), IL21R(5), IL22(2), IL22RA1(4), IL22RA2(1), IL23R(2), IL24(2), IL25(1), IL26(2), IL2RA(2), IL2RB(3), IL3(1), IL3RA(6), IL4(1), IL4R(8), IL5(2), IL5RA(3), IL6(2), IL6R(5), IL6ST(4), IL7(1), IL7R(6), IL9(2), IL9R(6), INHBA(4), INHBB(4), INHBC(3), INHBE(1), KDR(13), KIT(11), KITLG(1), LEP(1), LEPR(20), LIF(2), LIFR(13), LTA(4), LTBR(6), MET(4), MPL(4), NGFR(1), OSMR(4), PDGFB(1), PDGFC(3), PDGFRA(14), PDGFRB(8), PF4V1(1), PLEKHO2(2), PPBP(1), PRL(4), PRLR(8), RELT(5), TGFB1(1), TGFB2(3), TGFB3(1), TGFBR1(2), TNFRSF10A(3), TNFRSF10B(1), TNFRSF10D(1), TNFRSF11A(3), TNFRSF11B(2), TNFRSF13B(1), TNFRSF13C(2), TNFRSF14(1), TNFRSF19(4), TNFRSF1A(1), TNFRSF1B(2), TNFRSF21(6), TNFRSF25(2), TNFRSF4(2), TNFRSF6B(4), TNFRSF8(2), TNFRSF9(4), TNFSF10(1), TNFSF11(1), TNFSF13(1), TNFSF13B(2), TNFSF14(2), TNFSF15(1), TNFSF18(1), TNFSF4(3), TNFSF8(2), TNFSF9(1), TPO(11), TSLP(1), VEGFB(1), VEGFC(6), XCL1(1), XCL2(1), XCR1(3)	133839974	667	303	663	230	102	131	215	120	98	1	0.404	1.000	1.000
195	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADA(2), ADCY1(21), ADCY2(29), ADCY3(8), ADCY4(8), ADCY5(10), ADCY6(6), ADCY7(5), ADCY8(28), ADCY9(9), ADK(2), ADSL(5), ADSS(4), ADSSL1(6), AK1(1), AK2(1), AK5(12), AK7(2), ALLC(4), AMPD1(7), AMPD2(3), AMPD3(2), ATIC(5), CANT1(3), DCK(4), ENPP1(10), ENPP3(8), ENTPD1(4), ENTPD2(1), ENTPD3(2), ENTPD4(5), ENTPD5(3), ENTPD6(2), ENTPD8(2), FHIT(1), GART(4), GDA(7), GMPR(1), GMPR2(3), GMPS(7), GUCY1A2(10), GUCY1A3(9), GUCY1B3(7), GUCY2C(10), GUCY2D(9), GUCY2F(9), GUK1(1), HPRT1(2), IMPDH1(3), IMPDH2(1), ITPA(4), NME2(1), NME4(2), NME7(4), NPR1(4), NPR2(8), NT5C1A(2), NT5C1B(7), NT5C2(2), NT5E(1), NUDT2(1), NUDT5(2), NUDT9(1), PAPSS1(6), PAPSS2(6), PDE10A(20), PDE11A(3), PDE1A(6), PDE1C(14), PDE2A(4), PDE3B(4), PDE4A(5), PDE4B(7), PDE4C(4), PDE4D(7), PDE5A(9), PDE7A(4), PDE7B(1), PDE8A(3), PDE8B(12), PDE9A(3), PFAS(13), PKLR(3), PNPT1(6), POLA1(4), POLA2(2), POLD1(11), POLD2(1), POLD3(4), POLE(11), POLE2(1), POLR1A(10), POLR1B(4), POLR1C(2), POLR2A(11), POLR2B(10), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(3), POLR2G(4), POLR2H(1), POLR2I(1), POLR2J(2), POLR2L(2), POLR3A(9), POLR3B(4), POLR3G(1), POLR3GL(2), POLR3H(1), PPAT(3), PRIM1(3), PRIM2(1), PRPS1(3), PRPS1L1(5), PRPS2(2), PRUNE(2), RFC5(2), RRM1(1), RRM2(1), RRM2B(1), XDH(6)	124133963	621	300	618	204	111	131	188	102	89	0	0.170	1.000	1.000
196	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	139	APC(27), APC2(6), AXIN1(11), AXIN2(7), BTRC(1), CACYBP(5), CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), CCND1(4), CCND2(2), CER1(1), CHD8(16), CREBBP(39), CSNK1A1(1), CSNK1A1L(4), CSNK1E(6), CSNK2A1(7), CSNK2A2(3), CSNK2B(2), CTBP1(2), CTBP2(3), CTNNB1(6), CUL1(11), CXXC4(3), DAAM1(8), DAAM2(16), DKK1(2), DKK2(5), DVL1(7), DVL2(1), DVL3(9), FBXW11(3), FOSL1(3), FZD1(6), FZD10(5), FZD2(4), FZD3(2), FZD4(2), FZD5(1), FZD6(5), FZD7(1), FZD8(2), FZD9(2), GSK3B(3), JUN(1), LEF1(5), LRP5(9), LRP6(17), MAP3K7(8), MAPK10(4), MAPK8(4), MAPK9(4), MMP7(1), MYC(6), NFAT5(13), NFATC1(9), NFATC2(15), NFATC3(6), NFATC4(3), NKD1(8), NKD2(3), NLK(1), PLCB1(21), PLCB2(7), PLCB3(8), PLCB4(17), PORCN(2), PPARD(1), PPP2CB(3), PPP2R1A(3), PPP2R1B(4), PPP2R2A(2), PPP2R2B(4), PPP2R2C(1), PPP3CA(2), PPP3CB(1), PRICKLE1(8), PRICKLE2(7), PRKACA(4), PRKACB(3), PRKACG(3), PRKCA(7), PRKCG(12), PRKX(1), RAC2(2), RAC3(3), RBX1(3), ROCK1(19), ROCK2(10), SENP2(3), SFRP1(2), SFRP4(12), SFRP5(1), SIAH1(3), SKP1(1), SMAD2(4), SMAD3(4), SOX17(3), TBL1X(6), TBL1XR1(5), TBL1Y(3), TCF7(2), TCF7L1(2), TCF7L2(1), VANGL1(2), VANGL2(5), WIF1(1), WNT1(2), WNT10A(2), WNT10B(1), WNT11(2), WNT16(2), WNT2(3), WNT3(4), WNT3A(1), WNT4(2), WNT5A(3), WNT5B(1), WNT6(2), WNT7A(3), WNT7B(1), WNT8A(2), WNT8B(3), WNT9A(5), WNT9B(3)	117179899	642	294	636	201	107	136	194	106	97	2	0.0288	1.000	1.000
197	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(4), ACTA2(3), ACTN2(11), ACTN4(6), DES(3), DMD(53), MYBPC1(12), MYBPC2(8), MYBPC3(5), MYH3(14), MYH6(20), MYH7(16), MYH8(26), MYL1(1), MYL4(2), MYL9(4), MYOM1(15), NEB(41), TMOD1(2), TNNC2(1), TNNI2(4), TNNI3(1), TNNT1(2), TNNT2(4), TNNT3(2), TPM1(2), TPM2(2), TPM4(1), TTN(387), VIM(4)	103717356	656	288	651	187	90	159	237	98	67	5	0.180	1.000	1.000
198	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	127	ALCAM(7), CADM1(4), CADM3(5), CD2(1), CD22(3), CD226(5), CD274(1), CD276(1), CD28(3), CD34(6), CD4(1), CD40(7), CD40LG(5), CD58(2), CD6(1), CD80(5), CD86(2), CD8A(2), CD8B(2), CDH1(5), CDH15(3), CDH2(6), CDH3(8), CDH4(8), CDH5(7), CLDN10(4), CLDN11(1), CLDN15(3), CLDN16(6), CLDN17(3), CLDN18(3), CLDN2(2), CLDN22(2), CLDN23(1), CLDN4(1), CLDN6(2), CLDN7(1), CLDN8(1), CLDN9(1), CNTN1(10), CNTN2(8), CNTNAP1(9), CNTNAP2(27), CTLA4(2), ESAM(4), F11R(3), GLG1(4), HLA-C(5), HLA-DMB(1), HLA-DOA(3), HLA-DOB(3), HLA-DQA2(3), HLA-DQB1(2), HLA-DRA(1), HLA-DRB1(2), HLA-E(1), HLA-F(4), HLA-G(2), ICAM1(6), ICAM2(3), ICAM3(3), ICOS(1), ICOSLG(1), ITGA4(13), ITGA6(4), ITGA9(3), ITGAL(7), ITGAM(8), ITGAV(6), ITGB1(16), ITGB2(4), ITGB7(1), ITGB8(5), JAM2(2), L1CAM(10), MAG(5), MPZ(2), MPZL1(3), NCAM1(4), NCAM2(13), NEGR1(7), NEO1(4), NFASC(6), NLGN1(19), NLGN2(6), NLGN3(3), NRCAM(14), NRXN1(30), NRXN2(10), NRXN3(20), OCLN(1), PDCD1(2), PTPRC(19), PTPRF(17), PTPRM(24), PVR(3), PVRL1(1), PVRL2(3), PVRL3(9), SDC1(2), SDC2(2), SDC3(2), SDC4(1), SELE(7), SELL(2), SELP(15), SELPLG(1), SIGLEC1(13), SPN(3), VCAM1(10), VCAN(32)	109550739	633	286	628	236	100	133	180	114	106	0	0.571	1.000	1.000
199	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	90	ADCY1(21), ADCY2(29), ADCY3(8), ADCY4(8), ADCY5(10), ADCY6(6), ADCY7(5), ADCY8(28), ADCY9(9), ADRB1(3), CSNK1D(1), DRD1(2), DRD2(4), EGF(9), EGFR(19), GJA1(2), GJD2(2), GNA11(4), GNAI1(2), GNAI2(1), GNAI3(1), GNAS(12), GRM1(29), GRM5(12), GUCY1A2(10), GUCY1A3(9), GUCY1B3(7), GUCY2C(10), GUCY2D(9), GUCY2F(9), HTR2A(5), HTR2B(2), HTR2C(3), ITPR1(16), ITPR2(25), ITPR3(10), KRAS(1), MAP2K1(5), MAP2K2(6), MAP2K5(3), MAP3K2(1), MAPK7(6), NPR1(4), NPR2(8), NRAS(1), PDGFB(1), PDGFC(3), PDGFD(6), PDGFRA(14), PDGFRB(8), PLCB1(21), PLCB2(7), PLCB3(8), PLCB4(17), PRKACA(4), PRKACB(3), PRKACG(3), PRKCA(7), PRKCG(12), PRKG1(8), PRKG2(2), PRKX(1), RAF1(3), SOS1(9), SOS2(11), TJP1(12), TUBA1B(5), TUBA3C(10), TUBA3D(3), TUBA3E(7), TUBA4A(1), TUBA8(2), TUBAL3(4), TUBB(3), TUBB1(3), TUBB2A(1), TUBB3(1), TUBB6(4), TUBB8(2)	99622820	583	285	577	179	107	131	172	106	66	1	0.00390	1.000	1.000
200	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	161	ADORA1(4), ADORA2A(2), ADORA2B(1), ADORA3(3), ADRA1A(5), ADRA1B(3), ADRA1D(3), ADRA2C(3), ADRB1(3), ADRB3(2), AGTR2(2), AVPR1A(9), AVPR1B(7), AVPR2(2), BDKRB1(3), BDKRB2(3), BRS3(3), C3AR1(5), CCKAR(5), CCKBR(5), CCR1(1), CCR10(2), CCR2(4), CCR3(6), CCR4(4), CCR6(2), CCR7(2), CCR9(2), CCRL2(3), CHML(8), CHRM2(5), CHRM3(9), CHRM4(2), CHRM5(3), CMKLR1(3), CNR1(4), CX3CR1(1), CXCR3(1), CXCR4(2), DRD1(2), DRD2(4), DRD3(6), DRD4(1), DRD5(8), EDNRA(2), EDNRB(7), F2R(4), F2RL1(1), F2RL2(2), F2RL3(3), FPR1(7), FSHR(12), GALR1(4), GALR2(4), GALR3(2), GALT(2), GHSR(3), GNB2L1(1), GPR17(3), GPR173(1), GPR174(4), GPR27(2), GPR3(2), GPR35(2), GPR37(10), GPR37L1(5), GPR4(1), GPR50(6), GPR6(5), GPR63(6), GPR83(1), GRPR(1), HCRTR1(3), HCRTR2(7), HRH1(1), HRH2(3), HRH3(3), HTR1A(9), HTR1B(7), HTR1D(2), HTR1E(8), HTR1F(4), HTR2A(5), HTR2B(2), HTR2C(3), HTR4(2), HTR5A(8), HTR6(6), HTR7(7), LHCGR(9), LTB4R(3), MAS1(2), MC1R(2), MC3R(4), MC4R(4), MC5R(9), MLNR(4), MTNR1A(3), MTNR1B(3), NMBR(3), NMUR1(5), NMUR2(1), NPY1R(6), NPY2R(5), NPY5R(8), NTSR1(3), NTSR2(6), OPN1SW(1), OPN3(3), OPRD1(2), OPRK1(7), OPRL1(6), OPRM1(4), OR10A5(4), OR11A1(3), OR12D3(3), OR1C1(8), OR1F1(2), OR1Q1(2), OR2H1(4), OR5V1(6), OR7A5(7), OR8B8(1), OXTR(2), P2RY1(5), P2RY10(5), P2RY11(3), P2RY13(3), P2RY14(1), P2RY2(3), P2RY6(2), PTGDR(3), PTGER2(5), PTGER4(6), PTGFR(2), PTGIR(2), RGR(4), RHO(3), RRH(3), SSTR1(8), SSTR2(3), SSTR3(6), SSTR4(7), SUCNR1(1), TBXA2R(1), TRHR(7)	92000845	569	284	567	228	113	119	187	91	59	0	0.115	1.000	1.000
201	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	93	ADCY1(21), ADCY2(29), ADCY3(8), ADCY4(8), ADCY5(10), ADCY6(6), ADCY7(5), ADCY8(28), ADCY9(9), ATF4(5), CACNA1C(23), CACNA1D(21), CACNA1F(11), CACNA1S(16), CALM1(1), CALM2(2), CALM3(2), CALML3(1), CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), CDC42(3), CGA(1), EGFR(19), ELK1(2), FSHB(2), GNA11(4), GNAS(12), GNRHR(2), ITPR1(16), ITPR2(25), ITPR3(10), JUN(1), KRAS(1), LHB(2), MAP2K1(5), MAP2K2(6), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAP2K7(2), MAP3K1(6), MAP3K2(1), MAP3K3(3), MAP3K4(14), MAPK10(4), MAPK11(3), MAPK12(3), MAPK13(3), MAPK14(2), MAPK7(6), MAPK8(4), MAPK9(4), MMP14(4), MMP2(5), NRAS(1), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PLCB1(21), PLCB2(7), PLCB3(8), PLCB4(17), PLD1(15), PLD2(1), PRKACA(4), PRKACB(3), PRKACG(3), PRKCA(7), PRKCD(4), PRKX(1), PTK2B(4), RAF1(3), SOS1(9), SOS2(11)	95661740	535	283	529	181	106	123	152	90	64	0	0.0512	1.000	1.000
202	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	149	AKT1(2), AKT2(3), AKT3(6), BCL2L1(2), CBL(3), CBLB(7), CBLC(1), CCND1(4), CCND2(2), CISH(1), CNTFR(1), CREBBP(39), CRLF2(4), CSF2RA(1), CSF2RB(8), CSF3R(3), EPO(2), EPOR(2), GH1(4), GH2(4), GHR(8), IFNA10(1), IFNA14(1), IFNA16(4), IFNA17(3), IFNA2(1), IFNA21(2), IFNA4(4), IFNA6(1), IFNA8(3), IFNAR1(3), IFNAR2(2), IFNG(2), IFNGR1(4), IFNGR2(5), IFNK(1), IFNW1(2), IL10RA(5), IL10RB(2), IL11RA(2), IL12A(1), IL12B(4), IL12RB1(4), IL12RB2(11), IL13(1), IL13RA1(2), IL13RA2(4), IL19(4), IL2(2), IL20RA(3), IL21(3), IL21R(5), IL22(2), IL22RA1(4), IL22RA2(1), IL23R(2), IL24(2), IL26(2), IL2RA(2), IL2RB(3), IL3(1), IL3RA(6), IL4(1), IL4R(8), IL5(2), IL5RA(3), IL6(2), IL6R(5), IL6ST(4), IL7(1), IL7R(6), IL9(2), IL9R(6), IRF9(2), JAK1(11), JAK2(5), JAK3(6), LEP(1), LEPR(20), LIF(2), LIFR(13), MPL(4), MYC(6), OSMR(4), PIAS1(1), PIAS2(3), PIAS3(4), PIAS4(3), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PIM1(3), PRL(4), PRLR(8), PTPN11(2), PTPN6(2), SOCS1(1), SOCS2(1), SOCS3(1), SOCS4(2), SOCS5(7), SOCS7(2), SOS1(9), SOS2(11), SPRED1(3), SPRED2(5), SPRY1(3), SPRY2(2), SPRY3(3), SPRY4(2), STAM(2), STAM2(3), STAT1(7), STAT2(5), STAT3(6), STAT4(6), STAT5A(3), STAT5B(5), STAT6(5), TPO(11), TSLP(1), TYK2(8)	105156382	548	281	540	170	70	118	169	107	83	1	0.0906	1.000	1.000
203	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	128	ACACA(15), ACACB(20), AKT1(2), AKT2(3), AKT3(6), ARAF(2), BAD(1), BRAF(10), CALM1(1), CALM2(2), CALM3(2), CALML3(1), CBL(3), CBLB(7), CBLC(1), CRK(2), CRKL(3), EIF4EBP1(1), ELK1(2), FASN(10), FBP2(1), FLOT1(2), FLOT2(4), FOXO1(3), G6PC(2), G6PC2(7), GCK(4), GSK3B(3), GYS1(6), GYS2(7), IKBKB(12), INPP5D(9), INSR(3), IRS1(4), IRS2(6), IRS4(16), KRAS(1), LIPE(8), MAP2K1(5), MAP2K2(6), MAPK10(4), MAPK8(4), MAPK9(4), MKNK1(1), MKNK2(2), NRAS(1), PCK1(1), PCK2(4), PDE3A(18), PDE3B(4), PDPK1(4), PFKL(6), PFKM(6), PFKP(6), PHKA1(4), PHKA2(9), PHKB(3), PHKG1(3), PHKG2(2), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PKLR(3), PPARGC1A(6), PPP1CA(1), PPP1R3A(13), PPP1R3B(3), PPP1R3C(2), PPP1R3D(3), PRKAA1(4), PRKAA2(4), PRKAB1(4), PRKAB2(2), PRKACA(4), PRKACB(3), PRKACG(3), PRKAG2(2), PRKAG3(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PRKCI(3), PRKCZ(3), PRKX(1), PTPN1(3), PTPRF(17), PYGB(5), PYGL(9), PYGM(8), RAF1(3), RAPGEF1(5), RHEB(1), RHOQ(1), RPS6KB1(5), RPS6KB2(2), SH2B2(1), SHC1(3), SHC2(5), SHC3(6), SHC4(4), SLC2A4(3), SOCS1(1), SOCS2(1), SOCS3(1), SOCS4(2), SORBS1(7), SOS1(9), SOS2(11), SREBF1(5), TRIP10(6), TSC1(4), TSC2(8)	119336369	568	280	563	189	116	115	157	95	85	0	0.139	1.000	1.000
204	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	90	ADCY1(21), ADCY2(29), ADCY3(8), ADCY4(8), ADCY5(10), ADCY6(6), ADCY7(5), ADCY8(28), ADCY9(9), AKAP1(8), AKAP10(5), AKAP11(8), AKAP12(13), AKAP2(13), AKAP3(8), AKAP4(11), AKAP5(3), AKAP6(27), AKAP7(4), AKAP8(4), AKAP9(30), ARHGEF1(9), CALM1(1), CALM2(2), CALM3(2), CHMP1B(2), GNA11(4), GNA12(1), GNA13(2), GNA14(3), GNA15(4), GNAI2(1), GNAI3(1), GNAL(4), GNAO1(1), GNAZ(7), GNB1(3), GNB2(4), GNB3(6), GNB5(2), GNG10(1), GNG12(1), GNG13(2), ITPR1(16), KCNJ3(11), KRAS(1), NRAS(1), PALM2(2), PDE1A(6), PDE1B(4), PDE1C(14), PDE4A(5), PDE4B(7), PDE4C(4), PDE4D(7), PDE7A(4), PDE7B(1), PDE8A(3), PDE8B(12), PLCB3(8), PPP3CA(2), PRKACA(4), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PRKCA(7), PRKCD(4), PRKCE(3), PRKCG(12), PRKCH(4), PRKCI(3), PRKCQ(8), PRKCZ(3), PRKD1(15), PRKD3(9), RRAS(2), SLC9A1(4), USP5(5)	88186925	528	278	524	152	107	124	138	88	71	0	0.00315	1.000	1.000
205	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADA(2), ADCY1(21), ADCY2(29), ADCY3(8), ADCY4(8), ADCY5(10), ADCY6(6), ADCY7(5), ADCY8(28), ADK(2), ADSL(5), ADSS(4), AK1(1), AK2(1), AK5(12), ALLC(4), AMPD1(7), AMPD2(3), AMPD3(2), ATIC(5), ATP1B1(2), ATP5A1(1), ATP5B(2), ATP5C1(1), ATP5F1(1), ATP5G1(1), ATP5G2(2), ATP5G3(1), ATP5H(1), CANT1(3), DCK(4), ENPP1(10), ENPP3(8), ENTPD1(4), ENTPD2(1), FHIT(1), GART(4), GDA(7), GMPS(7), GUCY1A2(10), GUCY1A3(9), GUCY1B3(7), GUCY2C(10), GUCY2D(9), GUCY2F(9), GUK1(1), HPRT1(2), IMPDH1(3), IMPDH2(1), ITPA(4), NME2(1), NPR1(4), NPR2(8), NT5E(1), NUDT2(1), PAPSS1(6), PAPSS2(6), PDE1A(6), PDE4A(5), PDE4B(7), PDE4C(4), PDE4D(7), PDE5A(9), PDE6B(2), PDE6C(3), PDE7B(1), PDE8A(3), PDE9A(3), PFAS(13), PKLR(3), POLB(1), POLD1(11), POLD2(1), POLE(11), POLG(8), POLL(6), POLQ(22), POLR1B(4), POLR2A(11), POLR2B(10), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(3), POLR2G(4), POLR2H(1), POLR2I(1), POLR2J(2), POLR2L(2), POLRMT(6), PPAT(3), PRPS1(3), PRPS1L1(5), PRPS2(2), PRUNE(2), RRM1(1), RRM2(1)	97524512	506	272	503	159	87	107	162	74	76	0	0.0711	1.000	1.000
206	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	107	ACTN1(4), ACTN2(11), ACTN4(6), ARHGAP5(10), BCAR1(3), CDC42(3), CDH5(7), CLDN10(4), CLDN11(1), CLDN15(3), CLDN16(6), CLDN17(3), CLDN18(3), CLDN2(2), CLDN22(2), CLDN23(1), CLDN4(1), CLDN6(2), CLDN7(1), CLDN8(1), CLDN9(1), CTNNA1(8), CTNNA2(29), CTNNA3(13), CTNNB1(6), CTNND1(8), CXCL12(3), CXCR4(2), CYBB(3), ESAM(4), F11R(3), GNAI1(2), GNAI2(1), GNAI3(1), ICAM1(6), ITGA4(13), ITGAL(7), ITGAM(8), ITGB1(16), ITGB2(4), ITK(3), JAM2(2), MAPK11(3), MAPK12(3), MAPK13(3), MAPK14(2), MLLT4(13), MMP2(5), MMP9(1), MSN(3), MYL7(2), MYL9(4), NCF1(2), NCF2(6), NCF4(2), NOX1(6), NOX3(8), OCLN(1), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PLCG1(8), PLCG2(9), PRKCA(7), PRKCG(12), PTK2(8), PTK2B(4), PTPN11(2), PXN(2), RAC2(2), RAP1B(3), RAPGEF3(6), RAPGEF4(1), RASSF5(2), RHOH(1), ROCK1(19), ROCK2(10), SIPA1(3), THY1(2), TXK(5), VASP(1), VAV1(8), VAV2(4), VAV3(4), VCAM1(10), VCL(6)	92316933	486	259	479	170	82	92	132	88	91	1	0.525	1.000	1.000
207	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	96	ADCY1(21), ADCY2(29), ADCY3(8), ADCY4(8), ADCY5(10), ADCY6(6), ADCY7(5), ADCY8(28), ADCY9(9), CALM1(1), CALM2(2), CALM3(2), CALML3(1), CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), CREB1(1), CREB3L1(4), CREB3L2(3), CREB3L3(9), CREB3L4(2), CREBBP(39), CTNNB1(6), DCT(4), DVL1(7), DVL2(1), DVL3(9), EDN1(1), EDNRB(7), FZD1(6), FZD10(5), FZD2(4), FZD3(2), FZD4(2), FZD5(1), FZD6(5), FZD7(1), FZD8(2), FZD9(2), GNAI1(2), GNAI2(1), GNAI3(1), GNAO1(1), GNAS(12), GSK3B(3), KIT(11), KITLG(1), KRAS(1), LEF1(5), MAP2K1(5), MAP2K2(6), MC1R(2), MITF(6), NRAS(1), PLCB1(21), PLCB2(7), PLCB3(8), PLCB4(17), POMC(1), PRKACA(4), PRKACB(3), PRKACG(3), PRKCA(7), PRKCG(12), PRKX(1), RAF1(3), TCF7(2), TCF7L1(2), TCF7L2(1), TYR(8), TYRP1(4), WNT1(2), WNT10A(2), WNT10B(1), WNT11(2), WNT16(2), WNT2(3), WNT3(4), WNT3A(1), WNT4(2), WNT5A(3), WNT5B(1), WNT6(2), WNT7A(3), WNT7B(1), WNT8A(2), WNT8B(3), WNT9A(5), WNT9B(3)	78415402	468	259	463	150	103	86	134	83	60	2	0.0136	1.000	1.000
208	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	69	ACP1(1), ACTB(5), ACTG1(3), ACTN1(4), ACTN2(11), ACTN4(6), ACVR1B(5), ACVR1C(8), BAIAP2(2), CDC42(3), CDH1(5), CREBBP(39), CSNK2A1(7), CSNK2A2(3), CSNK2B(2), CTNNA1(8), CTNNA2(29), CTNNA3(13), CTNNB1(6), CTNND1(8), EGFR(19), ERBB2(11), FARP2(3), FER(6), FGFR1(2), FYN(5), IGF1R(13), INSR(3), IQGAP1(11), LEF1(5), LMO7(8), MAP3K7(8), MET(4), MLLT4(13), NLK(1), PARD3(15), PTPN1(3), PTPN6(2), PTPRB(22), PTPRF(17), PTPRJ(7), PTPRM(24), PVRL1(1), PVRL2(3), PVRL3(9), PVRL4(3), RAC2(2), RAC3(3), SMAD2(4), SMAD3(4), SNAI2(1), SORBS1(7), SSX2IP(6), TCF7(2), TCF7L1(2), TCF7L2(1), TGFBR1(2), TJP1(12), VCL(6), WAS(2), WASF1(3), WASF2(5), WASF3(5), WASL(2), YES1(2)	84358819	457	256	451	147	72	95	130	87	71	2	0.326	1.000	1.000
209	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	64	ADCY1(21), ADCY8(28), ARAF(2), ATF4(5), BRAF(10), CACNA1C(23), CALM1(1), CALM2(2), CALM3(2), CALML3(1), CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), CREBBP(39), GRIA1(17), GRIA2(16), GRIN1(4), GRIN2A(21), GRIN2B(23), GRIN2C(7), GRIN2D(6), GRM1(29), GRM5(12), ITPR1(16), ITPR2(25), ITPR3(10), KRAS(1), MAP2K1(5), MAP2K2(6), NRAS(1), PLCB1(21), PLCB2(7), PLCB3(8), PLCB4(17), PPP1CA(1), PPP1R12A(5), PPP1R1A(1), PPP3CA(2), PPP3CB(1), PRKACA(4), PRKACB(3), PRKACG(3), PRKCA(7), PRKCG(12), PRKX(1), RAF1(3), RAP1B(3), RAPGEF3(6), RPS6KA1(10), RPS6KA2(6), RPS6KA3(4), RPS6KA6(8)	70906136	477	255	472	164	80	109	134	93	60	1	0.103	1.000	1.000
210	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	82	ABL1(8), ABL2(10), AKT1(2), AKT2(3), AKT3(6), ARAF(2), BAD(1), BRAF(10), BTC(3), CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), CBL(3), CBLB(7), CBLC(1), CDKN1B(2), CRK(2), CRKL(3), EGF(9), EGFR(19), EIF4EBP1(1), ELK1(2), ERBB2(11), ERBB3(14), ERBB4(21), EREG(1), GAB1(5), GSK3B(3), JUN(1), KRAS(1), MAP2K1(5), MAP2K2(6), MAP2K4(2), MAP2K7(2), MAPK10(4), MAPK8(4), MAPK9(4), MYC(6), NCK1(5), NCK2(7), NRAS(1), NRG1(1), NRG2(5), NRG3(17), NRG4(3), PAK1(3), PAK2(8), PAK3(4), PAK4(1), PAK6(5), PAK7(9), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PLCG1(8), PLCG2(9), PRKCA(7), PRKCG(12), PTK2(8), RAF1(3), RPS6KB1(5), RPS6KB2(2), SHC1(3), SHC2(5), SHC3(6), SHC4(4), SOS1(9), SOS2(11), STAT5A(3), STAT5B(5)	75815462	430	251	424	139	60	88	140	83	58	1	0.342	1.000	1.000
211	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	71	CALM1(1), CALM2(2), CALM3(2), CALML3(1), CDIPT(1), CDS1(3), CDS2(3), DGKA(4), DGKB(12), DGKD(7), DGKE(5), DGKG(6), DGKH(4), DGKI(11), DGKQ(7), DGKZ(7), FN3K(3), IMPA1(2), IMPA2(4), INPP1(2), INPP4A(8), INPP4B(11), INPP5A(3), INPP5B(5), INPP5D(9), INPP5E(1), INPPL1(9), ITPK1(3), ITPKB(5), ITPR1(16), ITPR2(25), ITPR3(10), OCRL(4), PI4KA(7), PI4KB(2), PIK3C2A(6), PIK3C2B(10), PIK3C2G(13), PIK3C3(5), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PIP4K2B(3), PIP4K2C(3), PIP5K1A(4), PIP5K1B(8), PIP5K1C(2), PLCB1(21), PLCB2(7), PLCB3(8), PLCB4(17), PLCD1(4), PLCD3(2), PLCD4(2), PLCE1(21), PLCG1(8), PLCG2(9), PLCZ1(7), PRKCA(7), PRKCG(12), PTPMT1(2), SYNJ1(9), SYNJ2(9)	92234964	470	249	463	148	73	100	127	90	80	0	0.0642	1.000	1.000
212	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	72	ARAF(2), BRAF(10), CACNA1A(14), CRH(1), CRHR1(3), GNA11(4), GNA12(1), GNA13(2), GNAI1(2), GNAI2(1), GNAI3(1), GNAO1(1), GNAS(12), GNAZ(7), GRIA1(17), GRIA2(16), GRIA3(8), GRID2(21), GRM1(29), GRM5(12), GUCY1A2(10), GUCY1A3(9), GUCY1B3(7), GUCY2C(10), GUCY2D(9), GUCY2F(9), IGF1(1), IGF1R(13), ITPR1(16), ITPR2(25), ITPR3(10), KRAS(1), LYN(8), MAP2K1(5), MAP2K2(6), NOS1(9), NOS3(4), NPR1(4), NPR2(8), NRAS(1), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PLCB1(21), PLCB2(7), PLCB3(8), PLCB4(17), PPP2CB(3), PPP2R1A(3), PPP2R1B(4), PPP2R2A(2), PPP2R2B(4), PPP2R2C(1), PRKCA(7), PRKCG(12), PRKG1(8), PRKG2(2), RAF1(3), RYR1(34)	82750691	482	248	480	153	87	100	145	90	60	0	0.0723	1.000	1.000
213	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	81	ACVR1(5), ACVR1B(5), ACVRL1(4), AKT1(2), AURKB(3), BMPR2(6), BUB1(6), CDIPT(1), CDKL1(1), CDKL2(1), CDS1(3), CDS2(3), CLK1(3), CLK2(11), CLK4(2), COL4A3BP(7), CSNK2A1(7), CSNK2A2(3), CSNK2B(2), DGKA(4), DGKB(12), DGKD(7), DGKE(5), DGKG(6), DGKH(4), DGKQ(7), DGKZ(7), IMPA1(2), INPP1(2), INPP4A(8), INPP4B(11), INPP5A(3), INPPL1(9), ITPKB(5), MAP3K10(6), MOS(7), NEK1(9), NEK3(1), OCRL(4), PAK4(1), PIK3C2A(6), PIK3C2B(10), PIK3C2G(13), PIK3CB(7), PIK3CG(20), PLCB1(21), PLCB2(7), PLCB3(8), PLCB4(17), PLCD1(4), PLCG1(8), PLCG2(9), PLK3(6), PRKACA(4), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PRKCA(7), PRKCD(4), PRKCE(3), PRKCG(12), PRKCH(4), PRKCQ(8), PRKCZ(3), PRKD1(15), PRKG1(8), RAF1(3), RPS6KA1(10), RPS6KA2(6), RPS6KA3(4), RPS6KA4(3), RPS6KB1(5), STK11(7), TGFBR1(2), VRK1(1)	84052961	456	248	449	141	82	86	138	73	77	0	0.0824	1.000	1.000
214	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(16), ABCA10(13), ABCA12(19), ABCA13(39), ABCA2(17), ABCA3(10), ABCA4(15), ABCA5(6), ABCA6(11), ABCA7(9), ABCA8(10), ABCA9(14), ABCB1(20), ABCB11(9), ABCB4(13), ABCB5(11), ABCB6(6), ABCB7(5), ABCB8(6), ABCB9(3), ABCC1(5), ABCC10(9), ABCC11(9), ABCC12(10), ABCC2(9), ABCC3(4), ABCC4(5), ABCC5(8), ABCC6(3), ABCC8(20), ABCC9(29), ABCD1(4), ABCD2(5), ABCD3(4), ABCD4(6), ABCG1(3), ABCG2(4), ABCG4(9), ABCG8(13), CFTR(14), TAP1(6), TAP2(3)	89789433	434	246	432	141	65	90	131	70	78	0	0.0767	1.000	1.000
215	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(5), AMY2A(3), AMY2B(9), ASCC3(12), ATP13A2(2), DDX18(3), DDX19A(2), DDX23(3), DDX4(4), DDX41(5), DDX47(2), DDX50(1), DDX51(3), DDX52(6), DDX54(5), DDX55(3), DDX56(4), DHX58(2), ENPP1(10), ENPP3(8), ENTPD7(4), EP400(19), ERCC2(5), ERCC3(5), G6PC(2), G6PC2(7), GAA(3), GANC(6), GBA(3), GCK(4), GPI(3), GUSB(5), GYS1(6), GYS2(7), HK1(4), HK2(5), HK3(8), IFIH1(6), MGAM(32), MOV10L1(5), NUDT5(2), NUDT8(1), PGM1(5), PGM3(1), PYGB(5), PYGL(9), PYGM(8), RAD54B(6), RAD54L(5), RUVBL2(2), SETX(12), SI(61), SKIV2L2(4), SMARCA2(13), SMARCA5(2), UGDH(4), UGP2(2), UGT1A1(4), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A9(1), UGT2A1(6), UGT2A3(7), UGT2B10(11), UGT2B11(9), UGT2B15(4), UGT2B17(5), UGT2B28(6), UGT2B4(13), UGT2B7(7), UXS1(2)	94008768	461	244	459	145	55	90	152	94	69	1	0.421	1.000	1.000
216	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	105	ABL1(8), ANAPC1(8), ANAPC2(1), ANAPC4(2), ANAPC5(1), ANAPC7(1), ATM(16), ATR(25), BUB1(6), BUB1B(7), CCNA1(7), CCNA2(4), CCNB1(3), CCNB3(11), CCND1(4), CCND2(2), CCNE1(5), CCNE2(4), CDC14A(3), CDC14B(1), CDC16(2), CDC20(2), CDC23(4), CDC25A(2), CDC25B(4), CDC25C(4), CDC26(1), CDC27(8), CDC6(2), CDC7(1), CDK4(5), CDK6(2), CDKN1B(2), CDKN2C(1), CHEK1(1), CHEK2(5), CREBBP(39), CUL1(11), DBF4(3), E2F2(3), E2F3(3), ESPL1(10), FZR1(4), GADD45A(1), GADD45G(1), GSK3B(3), HDAC1(1), HDAC2(3), MAD1L1(4), MAD2L1(1), MAD2L2(2), MCM2(4), MCM3(4), MCM4(7), MCM5(2), MCM6(4), MCM7(9), MDM2(2), PCNA(1), PKMYT1(1), PLK1(3), PRKDC(28), RB1(18), RBL1(11), RBL2(6), RBX1(3), SFN(7), SKP1(1), SKP2(4), SMAD2(4), SMAD3(4), SMC1A(3), SMC1B(7), TFDP1(2), TGFB1(1), TGFB2(3), TGFB3(1), WEE1(1), YWHAB(2), YWHAE(2), YWHAG(1), YWHAH(2), YWHAQ(3), YWHAZ(2)	97716577	407	238	405	130	40	100	100	86	80	1	0.459	1.000	1.000
217	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	89	AKT1(2), AKT2(3), AKT3(6), BCL10(1), CARD11(12), CBL(3), CBLB(7), CBLC(1), CD247(2), CD28(3), CD3D(1), CD4(1), CD40LG(5), CD8A(2), CD8B(2), CDC42(3), CDK4(5), CHUK(6), CTLA4(2), FOS(6), FYN(5), GRAP2(2), ICOS(1), IFNG(2), IKBKB(12), IL2(2), IL4(1), IL5(2), ITK(3), JUN(1), KRAS(1), LAT(3), LCK(5), LCP2(2), MALT1(3), MAP3K8(4), NCK1(5), NCK2(7), NFAT5(13), NFATC1(9), NFATC2(15), NFATC3(6), NFATC4(3), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(1), NFKBIE(1), NRAS(1), PAK1(3), PAK2(8), PAK3(4), PAK4(1), PAK6(5), PAK7(9), PDCD1(2), PDK1(3), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PLCG1(8), PPP3CA(2), PPP3CB(1), PRKCQ(8), PTPN6(2), PTPRC(19), RASGRP1(8), SOS1(9), SOS2(11), TEC(2), VAV1(8), VAV2(4), VAV3(4), ZAP70(2)	74997338	383	237	381	126	63	73	111	68	68	0	0.412	1.000	1.000
218	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	88	AKT1(2), AKT3(6), BCAR1(3), CAPN1(3), CAPN10(4), CAPN11(2), CAPN2(6), CAPN3(5), CAPN5(2), CAPN6(10), CAPN7(2), CAPN9(4), CAPNS1(2), CAV1(1), CDC42(3), CRK(2), CSK(1), DOCK1(15), FYN(5), GIT2(3), ILK(4), ITGA10(9), ITGA11(10), ITGA2(7), ITGA2B(6), ITGA3(5), ITGA4(13), ITGA5(4), ITGA6(4), ITGA7(8), ITGA9(3), ITGAD(7), ITGAE(4), ITGAL(7), ITGAM(8), ITGAV(6), ITGAX(7), ITGB1(16), ITGB2(4), ITGB3(6), ITGB4(8), ITGB5(1), ITGB6(6), ITGB7(1), ITGB8(5), MAP2K1(5), MAP2K2(6), MAP2K3(4), MAP2K6(1), MAPK10(4), MAPK12(3), MAPK4(8), MAPK6(3), MAPK7(6), MYLK2(5), PAK1(3), PAK2(8), PAK3(4), PAK4(1), PAK6(5), PDPK1(4), PIK3R2(5), PTK2(8), PXN(2), RAC2(2), RAC3(3), RAP1B(3), RAPGEF1(5), RHO(3), ROCK1(19), ROCK2(10), SDCCAG8(7), SEPP1(1), SHC1(3), SHC3(6), SORBS1(7), SOS1(9), TLN1(24), TNS1(8), VASP(1), VAV2(4), VAV3(4), VCL(6), ZYX(2)	99922567	452	231	447	153	76	98	135	69	74	0	0.200	1.000	1.000
219	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	119	ARAF(2), BID(3), BRAF(10), CASP3(2), CD244(3), CD247(2), CD48(1), FAS(5), FASLG(1), FCGR3A(7), FYN(5), GZMB(2), HLA-C(5), HLA-E(1), HLA-G(2), ICAM1(6), ICAM2(3), IFNA10(1), IFNA14(1), IFNA16(4), IFNA17(3), IFNA2(1), IFNA21(2), IFNA4(4), IFNA6(1), IFNA8(3), IFNAR1(3), IFNAR2(2), IFNG(2), IFNGR1(4), IFNGR2(5), ITGAL(7), ITGB2(4), KIR2DL3(1), KIR3DL1(4), KLRC1(1), KLRC2(1), KLRC3(3), KLRK1(1), KRAS(1), LAT(3), LCK(5), LCP2(2), MAP2K1(5), MAP2K2(6), MICB(3), NCR1(6), NCR2(3), NFAT5(13), NFATC1(9), NFATC2(15), NFATC3(6), NFATC4(3), NRAS(1), PAK1(3), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PLCG1(8), PLCG2(9), PPP3CA(2), PPP3CB(1), PRF1(4), PRKCA(7), PRKCG(12), PTK2B(4), PTPN11(2), PTPN6(2), RAC2(2), RAC3(3), RAF1(3), SH2D1A(6), SH2D1B(2), SH3BP2(4), SHC1(3), SHC2(5), SHC3(6), SHC4(4), SOS1(9), SOS2(11), SYK(8), TNFRSF10A(3), TNFRSF10B(1), TNFRSF10D(1), TNFSF10(1), ULBP1(1), ULBP2(1), VAV1(8), VAV2(4), VAV3(4), ZAP70(2)	81994245	411	230	407	137	77	80	115	67	72	0	0.213	1.000	1.000
220	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	83	ACVR1(5), ACVR1B(5), ACVR1C(8), ACVR2A(1), ACVR2B(1), ACVRL1(4), AMHR2(1), BMP2(5), BMP4(4), BMP5(6), BMP6(7), BMP7(3), BMP8A(1), BMP8B(4), BMPR1B(4), BMPR2(6), CHRD(12), CREBBP(39), CUL1(11), DCN(4), E2F4(2), E2F5(6), GDF5(4), GDF6(6), ID1(1), ID2(1), ID3(1), IFNG(2), INHBA(4), INHBB(4), INHBC(3), INHBE(1), LEFTY1(2), LEFTY2(1), LTBP1(22), MYC(6), NOG(2), PITX2(2), PPP2CB(3), PPP2R1A(3), PPP2R1B(4), PPP2R2A(2), PPP2R2B(4), PPP2R2C(1), RBL1(11), RBL2(6), RBX1(3), ROCK1(19), ROCK2(10), RPS6KB1(5), RPS6KB2(2), SKP1(1), SMAD1(3), SMAD2(4), SMAD3(4), SMAD5(1), SMAD6(1), SMAD9(4), SMURF1(3), SMURF2(6), SP1(3), TFDP1(2), TGFB1(1), TGFB2(3), TGFB3(1), TGFBR1(2), THBS1(8), THBS2(11), THBS3(4), THBS4(7), ZFYVE16(10), ZFYVE9(8)	69028546	361	216	358	95	36	80	106	70	68	1	0.0109	1.000	1.000
221	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	94	AKT1(2), AKT2(3), AKT3(6), CCL3(1), CD14(1), CD40(7), CD80(5), CD86(2), CHUK(6), CXCL10(2), CXCL9(3), FADD(4), FOS(6), IFNA10(1), IFNA14(1), IFNA16(4), IFNA17(3), IFNA2(1), IFNA21(2), IFNA4(4), IFNA6(1), IFNA8(3), IFNAR1(3), IFNAR2(2), IKBKB(12), IKBKE(5), IL12A(1), IL12B(4), IL1B(1), IL6(2), IRAK1(3), IRAK4(3), IRF3(2), IRF5(3), IRF7(3), JUN(1), LBP(8), LY96(2), MAP2K1(5), MAP2K2(6), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAP2K7(2), MAP3K7(8), MAP3K8(4), MAPK10(4), MAPK11(3), MAPK12(3), MAPK13(3), MAPK14(2), MAPK8(4), MAPK9(4), NFKB1(5), NFKB2(5), NFKBIA(1), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), RELA(2), RIPK1(2), SPP1(2), STAT1(7), TBK1(3), TICAM1(5), TIRAP(1), TLR1(3), TLR2(3), TLR3(2), TLR4(16), TLR5(4), TLR6(4), TLR7(8), TLR8(7), TLR9(3), TOLLIP(2), TRAF3(6), TRAF6(3)	64937456	338	215	335	116	54	75	103	53	53	0	0.282	1.000	1.000
222	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	108	A4GNT(6), ALG1(4), ALG10(7), ALG10B(3), ALG11(3), ALG12(5), ALG13(4), ALG2(2), ALG3(1), ALG6(4), ALG8(1), B3GNT1(3), B3GNT2(1), B3GNT6(2), B3GNT7(3), B4GALT1(1), B4GALT2(5), B4GALT3(1), B4GALT4(2), B4GALT5(3), B4GALT7(2), C1GALT1(4), C1GALT1C1(3), CHPF(7), CHST1(4), CHST11(4), CHST12(5), CHST13(5), CHST14(2), CHST2(5), CHST4(4), CHST6(8), CHST7(2), CHSY1(3), DDOST(1), DPAGT1(1), EXT1(3), EXT2(5), EXTL1(3), EXTL2(3), EXTL3(2), FUT8(2), GALNT1(2), GALNT10(5), GALNT11(4), GALNT12(4), GALNT13(10), GALNT14(6), GALNT2(7), GALNT3(6), GALNT4(3), GALNT5(5), GALNT6(4), GALNT7(3), GALNT8(6), GALNTL5(5), GANAB(3), GCNT1(1), GCNT3(1), GCNT4(3), HS2ST1(5), HS3ST2(2), HS3ST3A1(3), HS3ST3B1(1), HS3ST5(6), HS6ST1(3), HS6ST2(1), HS6ST3(1), MAN1A1(2), MAN1A2(1), MAN1B1(4), MAN1C1(3), MAN2A1(4), MGAT1(4), MGAT2(2), MGAT3(5), MGAT4A(1), MGAT4B(3), MGAT5(4), MGAT5B(5), NDST1(1), NDST2(2), NDST3(7), NDST4(15), OGT(4), RPN1(2), RPN2(6), ST3GAL1(2), ST3GAL2(1), ST3GAL3(4), ST3GAL4(1), ST6GAL1(3), ST6GALNAC1(4), STT3B(2), UST(3), WBSCR17(9), XYLT1(10), XYLT2(3)	84055408	356	214	356	140	72	71	115	50	47	1	0.799	1.000	1.000
223	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	66	A2M(7), BDKRB1(3), BDKRB2(3), C1QA(3), C1QC(1), C1R(4), C1S(6), C2(6), C3(16), C3AR1(5), C4BPA(5), C4BPB(2), C5(11), C5AR1(2), C7(12), C8A(8), C8B(9), C8G(1), C9(15), CD46(2), CD59(1), CFB(4), CFH(19), CFI(5), CPB2(4), CR1(10), CR2(8), F10(4), F11(2), F12(2), F13A1(8), F13B(13), F2(3), F2R(4), F3(2), F5(20), F7(3), F8(8), F9(9), FGA(10), FGB(4), FGG(6), KLKB1(7), KNG1(4), MASP1(7), MASP2(5), MBL2(2), PLAT(3), PLG(13), PROC(2), PROS1(9), SERPINA1(5), SERPINA5(9), SERPINC1(4), SERPIND1(4), SERPINE1(8), SERPING1(5), TFPI(2), THBD(2), VWF(19)	67386746	380	210	377	133	47	98	110	68	56	1	0.529	1.000	1.000
224	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	73	ABL1(8), ACTN1(4), ACTR2(1), AKT1(2), AKT2(3), AKT3(6), ANGPTL2(3), ARHGEF6(7), ARHGEF7(2), BCAR1(3), BRAF(10), CAV1(1), CDC42(3), CRK(2), CSE1L(2), DOCK1(15), EPHB2(3), FYN(5), GRB7(1), ILK(4), ITGA1(4), ITGA10(9), ITGA11(10), ITGA2(7), ITGA3(5), ITGA4(13), ITGA5(4), ITGA6(4), ITGA7(8), ITGA9(3), ITGB3BP(1), MAP2K4(2), MAP2K7(2), MAP3K11(2), MAPK10(4), MAPK8(4), MAPK8IP1(3), MAPK8IP2(3), MAPK8IP3(8), MAPK9(4), MYLK(8), MYLK2(5), P4HB(1), PAK1(3), PAK2(8), PAK3(4), PAK4(1), PAK6(5), PAK7(9), PIK3CB(7), PKLR(3), PLCG1(8), PLCG2(9), PTK2(8), RAF1(3), RHO(3), ROCK1(19), ROCK2(10), SHC1(3), SOS1(9), SOS2(11), TLN1(24), TLN2(13), VASP(1), WAS(2), ZYX(2)	88152167	364	210	362	136	59	64	115	72	54	0	0.809	1.000	1.000
225	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	90	ACTB(5), BAD(1), BCL2(1), CABIN1(15), CALM1(1), CALM2(2), CALM3(2), CAMK2B(3), CD69(1), CEBPB(1), CNR1(4), CREBBP(39), CSNK2A1(7), CSNK2B(2), CTLA4(2), EGR2(5), FCER1A(4), FCGR3A(7), FKBP1B(1), FOS(6), FOSL1(3), GATA3(9), GSK3A(2), GSK3B(3), ICOS(1), IFNG(2), IL13(1), IL1B(1), IL2(2), IL2RA(2), IL3(1), IL4(1), IL6(2), ITK(3), JUNB(2), KPNA5(2), MAP2K7(2), MAPK14(2), MAPK8(4), MAPK9(4), MEF2A(3), MEF2B(5), MEF2D(1), MYF5(6), NCK2(7), NFAT5(13), NFATC1(9), NFATC2(15), NFATC3(6), NFATC4(3), NFKB2(5), NFKBIB(1), NFKBIE(1), NPPB(2), NUP214(12), OPRD1(2), P2RX7(1), PAK1(3), PIN1(1), PPP3CB(1), PTPRC(19), RELA(2), RPL13A(2), SFN(7), SLA(1), SP1(3), SP3(3), TGFB1(1), TRAF2(2), TRPV6(7), VAV1(8), VAV2(4), VAV3(4), XPO5(4)	65282583	322	205	321	113	45	62	96	65	53	1	0.499	1.000	1.000
226	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	78	ABL1(8), ATM(16), BUB1(6), BUB1B(7), CCNA1(7), CCNA2(4), CCNB1(3), CCNB3(11), CCND2(2), CCNE1(5), CCNE2(4), CDAN1(7), CDC14A(3), CDC14B(1), CDC20(2), CDC25A(2), CDC25B(4), CDC25C(4), CDC6(2), CDC7(1), CDH1(5), CDK4(5), CHEK1(1), CHEK2(5), DTX4(5), E2F2(3), E2F3(3), E2F4(2), E2F5(6), E2F6(1), ESPL1(10), GADD45A(1), GSK3B(3), HDAC1(1), HDAC2(3), HDAC3(3), HDAC4(10), HDAC5(3), HDAC6(8), HDAC8(1), MAD1L1(4), MAD2L1(1), MAD2L2(2), MCM2(4), MCM3(4), MCM4(7), MCM5(2), MCM6(4), MCM7(9), MDM2(2), MPEG1(7), MPL(4), PCNA(1), PLK1(3), PRKDC(28), PTPRA(4), RB1(18), RBL1(11), SKP2(4), TBC1D8(4), TFDP1(2), TGFB1(1), WEE1(1)	77872752	305	201	304	103	35	71	76	58	65	0	0.632	1.000	1.000
227	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	81	ATF2(1), BRAF(10), CHUK(6), CREB1(1), DAXX(5), ELK1(2), FOS(6), IKBKB(12), JUN(1), MAP2K1(5), MAP2K2(6), MAP2K3(4), MAP2K4(2), MAP2K5(3), MAP2K6(1), MAP2K7(2), MAP3K1(6), MAP3K10(6), MAP3K11(2), MAP3K12(8), MAP3K13(15), MAP3K2(1), MAP3K3(3), MAP3K4(14), MAP3K5(6), MAP3K6(6), MAP3K7(8), MAP3K8(4), MAP3K9(9), MAP4K1(4), MAP4K2(2), MAP4K3(7), MAP4K4(4), MAP4K5(2), MAPK10(4), MAPK11(3), MAPK12(3), MAPK13(3), MAPK14(2), MAPK4(8), MAPK6(3), MAPK7(6), MAPK8(4), MAPK9(4), MAPKAPK3(4), MAPKAPK5(2), MAX(1), MEF2A(3), MEF2B(5), MEF2D(1), MKNK1(1), MKNK2(2), MYC(6), NFKB1(5), NFKBIA(1), PAK1(3), PAK2(8), RAF1(3), RELA(2), RIPK1(2), RPS6KA1(10), RPS6KA2(6), RPS6KA3(4), RPS6KA4(3), RPS6KA5(5), RPS6KB1(5), RPS6KB2(2), SHC1(3), SP1(3), STAT1(7), TGFB1(1), TGFB2(3), TGFB3(1), TGFBR1(2), TRADD(1), TRAF2(2)	70775698	321	198	316	106	57	66	104	49	45	0	0.409	1.000	1.000
228	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	59	AKT1(2), AKT2(3), AKT3(6), BCL10(1), BLNK(5), BTK(8), CARD11(12), CD19(4), CD22(3), CD72(1), CD79A(1), CHUK(6), CR2(8), FCGR2B(1), FOS(6), GSK3B(3), IKBKB(12), INPP5D(9), JUN(1), KRAS(1), LILRB3(5), LYN(8), MALT1(3), NFAT5(13), NFATC1(9), NFATC2(15), NFATC3(6), NFATC4(3), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(1), NFKBIE(1), NRAS(1), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PLCG2(9), PPP3CA(2), PPP3CB(1), PTPN6(2), RAC2(2), RAC3(3), RASGRP3(8), SYK(8), VAV1(8), VAV2(4), VAV3(4)	54401076	286	193	284	95	55	58	75	49	48	1	0.245	1.000	1.000
229	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	60	AKT1(2), AKT2(3), AKT3(6), BAD(1), BCL2L1(2), CDC42(3), CDKN1B(2), CREB1(1), CREB5(8), EBP(1), ERBB4(21), F2RL2(2), GAB1(5), GADD45A(1), GSK3A(2), GSK3B(3), IGF1(1), IGFBP1(3), INPPL1(9), IRS1(4), IRS2(6), IRS4(16), MET(4), MYC(6), NOLC1(6), PAK1(3), PAK2(8), PAK3(4), PAK4(1), PAK6(5), PAK7(9), PARD3(15), PARD6A(1), PDK1(3), PIK3CD(8), PPP1R13B(2), PREX1(15), PTK2(8), PTPN1(3), RPS6KA1(10), RPS6KA2(6), RPS6KA3(4), RPS6KB1(5), SFN(7), SHC1(3), SLC2A4(3), SOS1(9), SOS2(11), TSC1(4), TSC2(8), YWHAB(2), YWHAE(2), YWHAG(1), YWHAH(2), YWHAQ(3), YWHAZ(2)	56091953	285	191	283	88	41	64	80	51	49	0	0.134	1.000	1.000
230	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	70	ACACB(20), ACSL1(3), ACSL3(3), ACSL4(6), ACSL5(5), ACSL6(3), ADIPOQ(3), ADIPOR1(3), ADIPOR2(3), AGRP(1), AKT1(2), AKT2(3), AKT3(6), CAMKK1(1), CAMKK2(6), CD36(2), CHUK(6), CPT1A(6), CPT1B(4), CPT1C(8), CPT2(7), G6PC(2), G6PC2(7), IKBKB(12), IRS1(4), IRS2(6), IRS4(16), JAK1(11), JAK2(5), JAK3(6), LEP(1), LEPR(20), MAPK10(4), MAPK8(4), MAPK9(4), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(1), NFKBIE(1), NPY(5), PCK1(1), PCK2(4), POMC(1), PPARA(2), PPARGC1A(6), PRKAA1(4), PRKAA2(4), PRKAB1(4), PRKAB2(2), PRKAG2(2), PRKAG3(3), PRKCQ(8), PTPN11(2), RELA(2), RXRA(5), RXRB(3), RXRG(7), SLC2A1(4), SLC2A4(3), SOCS3(1), STAT3(6), STK11(7), TNFRSF1A(1), TNFRSF1B(2), TRADD(1), TRAF2(2), TYK2(8)	63166369	316	190	316	101	54	62	93	55	51	1	0.120	1.000	1.000
231	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	77	AIFM1(1), AKT1(2), AKT2(3), AKT3(6), APAF1(12), ATM(16), BAD(1), BAX(1), BCL2(1), BCL2L1(2), BID(3), BIRC2(2), BIRC3(2), CAPN1(3), CAPN2(6), CASP10(2), CASP3(2), CASP6(5), CASP7(3), CASP9(1), CFLAR(2), CHUK(6), CSF2RB(8), FADD(4), FAS(5), FASLG(1), IKBKB(12), IL1A(1), IL1B(1), IL1R1(4), IL1RAP(6), IL3(1), IL3RA(6), IRAK1(3), IRAK2(2), IRAK3(9), IRAK4(3), NFKB1(5), NFKB2(5), NFKBIA(1), NTRK1(3), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PPP3CA(2), PPP3CB(1), PRKACA(4), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), RELA(2), RIPK1(2), TNFRSF10A(3), TNFRSF10B(1), TNFRSF10D(1), TNFRSF1A(1), TNFSF10(1), TRADD(1), TRAF2(2)	60402234	265	186	262	82	46	60	62	48	49	0	0.170	1.000	1.000
232	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	70	AKT1(2), AKT2(3), AKT3(6), BTK(8), FCER1A(4), FYN(5), GAB2(4), IL13(1), IL3(1), IL4(1), IL5(2), INPP5D(9), KRAS(1), LAT(3), LCP2(2), LYN(8), MAP2K1(5), MAP2K2(6), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAP2K7(2), MAPK10(4), MAPK11(3), MAPK12(3), MAPK13(3), MAPK14(2), MAPK8(4), MAPK9(4), MS4A2(5), NRAS(1), PDK1(3), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PLCG1(8), PLCG2(9), PRKCA(7), PRKCD(4), PRKCE(3), RAC2(2), RAC3(3), RAF1(3), SOS1(9), SOS2(11), SYK(8), VAV1(8), VAV2(4), VAV3(4)	52007868	278	184	276	96	49	49	85	46	48	1	0.546	1.000	1.000
233	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	54	ASH1L(20), ASH2L(3), CARM1(5), CTCFL(4), DOT1L(9), EED(3), EHMT1(7), EHMT2(11), EZH1(5), EZH2(5), FBXO11(7), HCFC1(8), HSF4(1), JMJD4(2), JMJD6(2), KDM6A(17), MEN1(3), OGT(4), PAXIP1(5), PPP1CA(1), PRDM2(14), PRDM7(3), PRDM9(37), PRMT1(2), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(4), RBBP5(2), SATB1(6), SETD1A(11), SETD2(12), SETD7(4), SETD8(1), SETDB1(10), SETDB2(2), SETMAR(2), SMYD3(2), STK38(3), SUV39H1(4), SUV39H2(2), SUV420H1(8), SUV420H2(4), SUZ12(2), WHSC1(9), WHSC1L1(6)	86174587	280	181	275	80	43	51	84	50	52	0	0.173	1.000	1.000
234	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	45	FN3K(3), IMPA1(2), IMPA2(4), INPP1(2), INPP4A(8), INPP4B(11), INPP5A(3), INPP5B(5), INPP5E(1), INPPL1(9), IPMK(2), ISYNA1(4), ITPK1(3), ITPKB(5), MINPP1(4), MIOX(4), OCRL(4), PI4KA(7), PI4KB(2), PIK3C3(5), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIP4K2B(3), PIP4K2C(3), PIP5K1A(4), PIP5K1B(8), PIP5K1C(2), PLCB1(21), PLCB2(7), PLCB3(8), PLCB4(17), PLCD1(4), PLCD3(2), PLCD4(2), PLCE1(21), PLCG1(8), PLCG2(9), PLCZ1(7), PTPMT1(2), SYNJ1(9), SYNJ2(9)	54225122	269	181	264	93	53	50	79	48	39	0	0.242	1.000	1.000
235	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CD2BP2(6), CDC40(3), CLK2(11), CLK3(4), CLK4(2), COL2A1(6), CPSF1(6), CPSF2(5), CPSF3(2), CSTF1(2), CSTF2(2), CSTF2T(2), CSTF3(2), DDX1(5), DDX20(4), DHX15(4), DHX16(9), DHX38(3), DHX8(5), DHX9(7), DICER1(15), DNAJC8(2), FUS(4), GIPC1(3), LSM2(1), METTL3(5), NCBP1(6), NCBP2(3), NONO(5), NUDT21(3), NXF1(4), PABPN1(4), PAPOLA(3), PHF5A(2), POLR2A(11), PRPF18(1), PRPF3(7), PRPF4(2), PRPF4B(7), PRPF8(13), PTBP1(3), PTBP2(4), RBM17(1), RBM5(9), RNGTT(2), RNMT(5), RNPS1(5), SF3A1(2), SF3A2(3), SF3A3(2), SF3B1(6), SF3B2(4), SF3B5(1), SNRPA(3), SNRPA1(1), SNRPB(1), SNRPB2(1), SNRPD2(2), SNRPE(1), SNRPN(8), SNURF(1), SPOP(5), SRPK1(1), SRPK2(8), SRRM1(4), SUPT5H(4), U2AF1(2), U2AF2(2), XRN2(8)	80511676	290	178	288	102	33	71	81	49	56	0	0.804	1.000	1.000
236	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	65	AGTR2(2), ATP8A1(17), AVPR1A(9), AVPR1B(7), AVPR2(2), BDKRB1(3), BDKRB2(3), BRS3(3), C3AR1(5), CCKAR(5), CCKBR(5), CCR1(1), CCR10(2), CCR2(4), CCR3(6), CCR4(4), CCR6(2), CCR7(2), CX3CR1(1), CXCR3(1), CXCR4(2), EDNRA(2), EDNRB(7), FPR1(7), FSHR(12), GALR1(4), GALR2(4), GALR3(2), GALT(2), GHSR(3), GNB2L1(1), GNRHR(2), GRPR(1), LHCGR(9), MC1R(2), MC2R(7), MC3R(4), MC4R(4), MC5R(9), NMBR(3), NPY1R(6), NPY2R(5), NPY5R(8), NTSR1(3), NTSR2(6), OPRD1(2), OPRK1(7), OPRL1(6), OPRM1(4), OXTR(2), SSTR1(8), SSTR2(3), SSTR3(6), SSTR4(7), TACR1(3), TACR2(4), TACR3(6), TRHR(7), TSHR(4)	39301078	268	178	268	97	50	62	83	38	35	0	0.0556	1.000	1.000
237	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	26	BRAF(10), CPEB1(6), EGFR(19), ERBB2(11), ERBB4(21), ETS1(4), ETS2(7), ETV6(6), ETV7(4), FMN2(41), KRAS(1), MAP2K1(5), NOTCH2(21), NOTCH3(23), NOTCH4(8), PIWIL1(11), PIWIL2(9), PIWIL3(7), PIWIL4(3), RAF1(3), SOS1(9), SOS2(11), SPIRE1(5), SPIRE2(1)	36177175	246	174	242	77	34	47	81	41	43	0	0.635	1.000	1.000
238	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	65	AKT1(2), AKT2(3), AKT3(6), BAD(1), CASP9(1), CDC42(3), KDR(13), KRAS(1), MAP2K1(5), MAP2K2(6), MAPK11(3), MAPK12(3), MAPK13(3), MAPK14(2), MAPKAPK3(4), NFAT5(13), NFATC1(9), NFATC2(15), NFATC3(6), NFATC4(3), NOS3(4), NRAS(1), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PLCG1(8), PLCG2(9), PPP3CA(2), PPP3CB(1), PRKCA(7), PRKCG(12), PTGS2(4), PTK2(8), PXN(2), RAC2(2), RAC3(3), RAF1(3), SHC2(5), SPHK2(3)	52040639	259	172	257	97	55	50	72	41	41	0	0.569	1.000	1.000
239	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	53	ADORA3(3), ALG6(4), CCKBR(5), CCR2(4), CCR3(6), CELSR1(23), CELSR2(25), CELSR3(17), CHRM2(5), CHRM3(9), CXCR3(1), DRD4(1), EDNRA(2), EMR2(2), EMR3(3), F2R(4), FSHR(12), GHRHR(4), GNRHR(2), GPR116(8), GPR132(4), GPR133(9), GPR135(1), GPR143(1), GPR17(3), GPR18(1), GPR55(1), GPR56(2), GPR61(3), GPR84(3), GRM1(29), GRPR(1), HRH4(3), LGR6(10), LPHN2(11), LPHN3(24), LTB4R2(3), NTSR1(3), OR2M4(6), P2RY11(3), P2RY13(3), PTGFR(2), SMO(3), SSTR2(3), TAAR5(1), TSHR(4), VN1R1(2)	50653530	279	171	278	112	51	62	85	47	34	0	0.460	1.000	1.000
240	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	42	ACTR2(1), AKT1(2), AKT2(3), AKT3(6), ANGPTL2(3), ARHGAP1(4), ARHGAP4(9), ARHGEF11(4), BTK(8), CDC42(3), CFL1(2), GDI1(4), GDI2(5), INPPL1(9), ITPR1(16), ITPR2(25), ITPR3(10), LIMK1(5), MYLK(8), MYLK2(5), PAK1(3), PAK2(8), PAK3(4), PAK4(1), PAK6(5), PAK7(9), PDK1(3), PIK3CD(8), PIK3CG(20), PIK3R1(10), PITX2(2), PPP1R13B(2), RACGAP1(5), RHO(3), ROCK1(19), ROCK2(10), SAG(1), WASF1(3), WASL(2)	50927844	250	166	248	101	41	65	64	44	35	1	0.768	1.000	1.000
241	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(5), AMY2A(3), AMY2B(9), ENPP1(10), ENPP3(8), G6PC(2), GAA(3), GANAB(3), GCK(4), GPI(3), GUSB(5), GYS1(6), GYS2(7), HK1(4), HK2(5), HK3(8), MGAM(32), PGM1(5), PGM3(1), PYGB(5), PYGL(9), PYGM(8), SI(61), UCHL3(1), UGDH(4), UGT1A1(4), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A9(1), UGT2B15(4), UGT2B4(13), UXS1(2)	43197822	248	165	246	84	30	45	81	51	40	1	0.626	1.000	1.000
242	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	62	ATM(16), CCNA1(7), CCNB1(3), CCND1(4), CCND2(2), CCNE1(5), CCNE2(4), CCNG2(4), CDC25A(2), CDK4(5), CDKN1B(2), CDKN2C(1), CREB3L1(4), CREB3L3(9), CREB3L4(2), E2F2(3), E2F3(3), E2F4(2), E2F5(6), E2F6(1), GADD45A(1), GBA2(6), MCM2(4), MCM3(4), MCM4(7), MCM5(2), MCM6(4), MCM7(9), MDM2(2), MNAT1(1), MYC(6), MYT1(12), NACA(25), PCNA(1), POLA2(2), POLE(11), POLE2(1), PRIM1(3), RB1(18), RBL1(11), RPA1(5), RPA2(1), TFDP1(2), TFDP2(1), TNXB(23), WEE1(1)	57694492	248	164	245	71	28	65	70	38	46	1	0.114	1.000	1.000
243	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	64	ADAM10(5), ADAM17(5), ATP6AP1(2), ATP6V0A1(4), ATP6V0A2(3), ATP6V0A4(6), ATP6V0B(1), ATP6V0C(1), ATP6V0D1(2), ATP6V0D2(3), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(3), ATP6V1C1(4), ATP6V1C2(3), ATP6V1D(2), ATP6V1E1(2), ATP6V1E2(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(3), ATP6V1H(3), CASP3(2), CDC42(3), CHUK(6), CSK(1), CXCL1(3), EGFR(19), F11R(3), GIT1(5), IGSF5(4), IKBKB(12), JAM2(2), JUN(1), LYN(8), MAP2K4(2), MAPK10(4), MAPK11(3), MAPK12(3), MAPK13(3), MAPK14(2), MAPK8(4), MAPK9(4), MET(4), NFKB1(5), NFKB2(5), NFKBIA(1), NOD1(7), PAK1(3), PLCG1(8), PLCG2(9), PTPN11(2), PTPRZ1(16), RELA(2), TCIRG1(8), TJP1(12)	53097613	236	164	235	77	26	52	74	46	38	0	0.460	1.000	1.000
244	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	44	AKT1(2), AKT2(3), AKT3(6), BAD(1), BCL2(1), BCR(2), BLNK(5), BTK(8), CD19(4), CD22(3), CR2(8), CSK(1), DAG1(5), FLOT1(2), FLOT2(4), GSK3A(2), GSK3B(3), INPP5D(9), ITPR1(16), ITPR2(25), ITPR3(10), LYN(8), MAP4K1(4), NFATC1(9), NFATC2(15), NR0B2(1), PDK1(3), PIK3CD(8), PIK3R1(10), PLCG2(9), PPP1R13B(2), PPP3CA(2), PPP3CB(1), PTPRC(19), RAF1(3), SHC1(3), SOS1(9), SOS2(11), SYK(8), VAV1(8)	54031389	253	164	252	94	43	58	56	55	40	1	0.528	1.000	1.000
245	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	82	CD14(1), CD19(4), CD1A(7), CD1B(3), CD1C(5), CD1D(5), CD2(1), CD22(3), CD33(2), CD34(6), CD36(2), CD38(5), CD3D(1), CD4(1), CD44(3), CD5(1), CD59(1), CD7(2), CD8A(2), CD8B(2), CD9(1), CR1(10), CR2(8), CSF1(2), CSF1R(2), CSF2RA(1), CSF3R(3), DNTT(3), EPO(2), EPOR(2), FCER2(1), FCGR1A(1), FLT3(6), FLT3LG(1), GP5(4), GP9(2), HLA-DRA(1), HLA-DRB1(2), IL11RA(2), IL1A(1), IL1B(1), IL1R1(4), IL1R2(1), IL2RA(2), IL3(1), IL3RA(6), IL4(1), IL4R(8), IL5(2), IL5RA(3), IL6(2), IL6R(5), IL7(1), IL7R(6), IL9R(6), ITGA1(4), ITGA2(7), ITGA2B(6), ITGA3(5), ITGA4(13), ITGA5(4), ITGA6(4), ITGAM(8), ITGB3(6), KIT(11), KITLG(1), MME(16), MS4A1(3), TFRC(7), THPO(1), TPO(11)	61431156	268	162	265	113	40	55	75	54	44	0	0.958	1.000	1.000
246	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACADL(4), ACADM(3), ACOX1(1), ACOX2(2), ACOX3(2), ACSL1(3), ACSL3(3), ACSL4(6), ACSL5(5), ACSL6(3), ADIPOQ(3), ANGPTL4(3), APOA2(1), APOA5(2), AQP7(3), CD36(2), CPT1A(6), CPT1B(4), CPT1C(8), CPT2(7), CYP27A1(3), CYP4A11(13), CYP4A22(9), CYP7A1(6), CYP8B1(6), DBI(4), EHHADH(5), FABP1(4), FABP2(2), FABP3(1), FABP4(4), FABP5(1), FABP6(3), FABP7(1), FADS2(4), GK(5), GK2(8), HMGCS2(2), ILK(4), LPL(4), ME1(2), MMP1(7), NR1H3(1), OLR1(1), PCK1(1), PCK2(4), PDPK1(4), PLTP(2), PPARA(2), PPARD(1), PPARG(1), RXRA(5), RXRB(3), RXRG(7), SCD(1), SCP2(2), SLC27A1(3), SLC27A2(2), SLC27A4(3), SLC27A5(4), SLC27A6(6), SORBS1(7), UBC(5), UCP1(1)	49785711	235	161	234	82	39	55	65	35	40	1	0.347	1.000	1.000
247	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	33	AKT1(2), AKT2(3), AKT3(6), ASAH1(1), BRAF(10), DAG1(5), DRD2(4), EGFR(19), EPHB2(3), ITPKB(5), ITPR1(16), ITPR2(25), ITPR3(10), KCNJ3(11), KCNJ5(3), KCNJ9(1), PI3(2), PIK3CB(7), PITX2(2), PLCB1(21), PLCB2(7), PLCB3(8), PLCB4(17), RAF1(3), RGS20(4), SHC1(3), SOS1(9), SOS2(11), STAT3(6)	43856905	224	159	223	76	33	50	63	55	23	0	0.310	1.000	1.000
248	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	56	BMP2(5), BMP4(4), BMP5(6), BMP6(7), BMP7(3), BMP8A(1), BMP8B(4), BTRC(1), CSNK1A1(1), CSNK1A1L(4), CSNK1D(1), CSNK1E(6), CSNK1G1(1), CSNK1G2(1), CSNK1G3(1), DHH(1), FBXW11(3), GLI1(7), GLI2(15), GLI3(12), GSK3B(3), HHIP(6), IHH(2), LRP2(42), PRKACA(4), PRKACB(3), PRKACG(3), PRKX(1), PTCH1(14), PTCH2(11), RAB23(2), SHH(2), SMO(3), STK36(6), SUFU(3), WNT1(2), WNT10A(2), WNT10B(1), WNT11(2), WNT16(2), WNT2(3), WNT3(4), WNT3A(1), WNT4(2), WNT5A(3), WNT5B(1), WNT6(2), WNT7A(3), WNT7B(1), WNT8A(2), WNT8B(3), WNT9A(5), WNT9B(3), ZIC2(6)	46317598	237	158	236	89	51	45	83	33	25	0	0.579	1.000	1.000
249	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	AICDA(3), CAD(5), CANT1(3), CTPS2(1), DCK(4), DHODH(6), DPYD(16), DPYS(7), ENTPD1(4), ENTPD3(2), ENTPD4(5), ENTPD5(3), ENTPD6(2), ENTPD8(2), ITPA(4), NME2(1), NME4(2), NME7(4), NT5C1A(2), NT5C1B(7), NT5C2(2), NT5E(1), NUDT2(1), PNPT1(6), POLA1(4), POLA2(2), POLD1(11), POLD2(1), POLD3(4), POLE(11), POLE2(1), POLR1A(10), POLR1B(4), POLR1C(2), POLR2A(11), POLR2B(10), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(3), POLR2G(4), POLR2H(1), POLR2I(1), POLR2J(2), POLR2L(2), POLR3A(9), POLR3B(4), POLR3G(1), POLR3GL(2), POLR3H(1), PRIM1(3), PRIM2(1), RFC5(2), RRM1(1), RRM2(1), RRM2B(1), TXNRD1(6), TXNRD2(2), TYMS(2), UCK1(3), UCK2(4), UMPS(2), UPB1(2), UPP1(3), UPP2(4), UPRT(2)	61520900	236	156	236	94	40	40	67	50	39	0	0.927	1.000	1.000
250	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	41	ADAM17(5), APH1A(4), CREBBP(39), CTBP1(2), CTBP2(3), DLL1(5), DLL3(2), DLL4(2), DTX1(4), DTX2(1), DTX3(5), DTX3L(2), DTX4(5), DVL1(7), DVL2(1), DVL3(9), HDAC1(1), HDAC2(3), JAG1(7), JAG2(8), LFNG(2), MAML1(6), MAML2(6), MAML3(2), MFNG(2), NCOR2(24), NCSTN(2), NOTCH2(21), NOTCH3(23), NOTCH4(8), NUMB(3), NUMBL(3), PSEN2(1), PTCRA(3), RBPJ(8), RBPJL(4), RFNG(3), SNW1(3)	45988128	239	155	238	96	47	51	59	33	48	1	0.794	1.000	1.000
251	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	47	ACOX1(1), APOA2(1), CD36(2), CPT1B(4), CREBBP(39), DUSP1(2), EHHADH(5), FABP1(4), HSD17B4(5), JUN(1), LPL(4), ME1(2), MYC(6), NCOA1(7), NCOR1(21), NCOR2(24), NFKBIA(1), NR0B2(1), NR1H3(1), NR2F1(3), NRIP1(9), PIK3R1(10), PPARA(2), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PRKCA(7), PTGS2(4), RB1(18), RELA(2), RXRA(5), SP1(3), STAT5A(3), STAT5B(5)	42216979	218	154	211	61	24	53	59	29	52	1	0.0579	1.000	1.000
252	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	56	APC(27), AXIN1(11), CCND1(4), CCND2(2), CSNK1E(6), CTNNB1(6), DVL1(7), DVL2(1), DVL3(9), FBXW2(2), FOSL1(3), FZD1(6), FZD10(5), FZD2(4), FZD3(2), FZD5(1), FZD6(5), FZD7(1), FZD8(2), FZD9(2), GSK3B(3), JUN(1), LDLR(5), MAPK10(4), MAPK9(4), MYC(6), PAFAH1B1(1), PPP2R5C(3), PPP2R5E(3), PRKCA(7), PRKCD(4), PRKCE(3), PRKCG(12), PRKCH(4), PRKCI(3), PRKCQ(8), PRKCZ(3), PRKD1(15), SFRP4(12), TCF7(2), WNT1(2), WNT10A(2), WNT10B(1), WNT11(2), WNT16(2), WNT2(3), WNT3(4), WNT4(2), WNT5A(3), WNT5B(1), WNT6(2), WNT7A(3), WNT7B(1)	45136374	237	150	233	87	38	51	75	48	24	1	0.465	1.000	1.000
253	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	61	APAF1(12), ATM(16), ATR(25), BAI1(8), BAX(1), BID(3), CASP3(2), CASP9(1), CCNB1(3), CCNB3(11), CCND1(4), CCND2(2), CCNE1(5), CCNE2(4), CCNG1(1), CCNG2(4), CDK4(5), CDK6(2), CHEK1(1), CHEK2(5), DDB2(4), EI24(2), FAS(5), GADD45A(1), GADD45G(1), GTSE1(8), IGF1(1), IGFBP3(1), MDM2(2), MDM4(1), PERP(1), PMAIP1(2), PPM1D(6), RCHY1(1), RFWD2(2), RRM2(1), RRM2B(1), SERPINE1(8), SESN1(2), SESN2(3), SESN3(3), SFN(7), SIAH1(3), STEAP3(4), THBS1(8), TNFRSF10B(1), TSC2(8), ZMAT3(2)	47227163	204	149	204	59	22	52	42	46	42	0	0.187	1.000	1.000
254	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(4), AKT1(2), BDKRB2(3), CALM1(1), CALM2(2), CALM3(2), CAV1(1), FLT1(17), FLT4(13), KDR(13), NOS3(4), PDE2A(4), PDE3A(18), PDE3B(4), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PRKG1(8), PRKG2(2), RYR2(79), SLC7A1(4), SYT1(8)	30730065	205	149	205	74	34	52	58	36	24	1	0.516	1.000	1.000
255	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	45	AKT1(2), AKT2(3), AKT3(6), BRD4(9), CAP1(3), CBL(3), CDC42(3), F2RL2(2), FLOT1(2), FLOT2(4), GSK3A(2), GSK3B(3), IGFBP1(3), INPPL1(9), IRS1(4), IRS2(6), IRS4(16), LNPEP(5), PARD3(15), PARD6A(1), PDK1(3), PIK3CD(8), PIK3R1(10), PTPN1(3), RAF1(3), RPS6KA1(10), RPS6KA2(6), RPS6KA3(4), RPS6KB1(5), SERPINB6(4), SFN(7), SHC1(3), SLC2A4(3), SORBS1(7), SOS1(9), SOS2(11), YWHAB(2), YWHAE(2), YWHAG(1), YWHAH(2), YWHAQ(3), YWHAZ(2)	42074484	209	148	208	61	36	49	55	36	33	0	0.128	1.000	1.000
256	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ADCY4(8), ADCY6(6), ADCY8(28), CACNA1A(14), CACNA1B(13), GNAS(12), GNAT3(6), GNB1(3), GNB3(6), GNG13(2), GRM4(2), ITPR3(10), KCNB1(3), PDE1A(6), PLCB2(7), PRKACA(4), PRKACB(3), PRKACG(3), PRKX(1), SCNN1A(4), SCNN1B(6), SCNN1G(6), TAS1R1(8), TAS1R2(3), TAS1R3(3), TAS2R1(3), TAS2R10(2), TAS2R13(1), TAS2R14(5), TAS2R16(4), TAS2R3(2), TAS2R38(3), TAS2R39(1), TAS2R40(6), TAS2R41(3), TAS2R42(2), TAS2R43(1), TAS2R46(5), TAS2R50(1), TAS2R60(3), TAS2R7(2), TAS2R8(7), TAS2R9(2), TRPM5(5)	43345617	225	147	223	110	49	40	54	46	36	0	0.967	1.000	1.000
257	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	50	ACTG1(3), APAF1(12), ARHGDIB(1), BAG4(6), BCL2(1), BID(3), BIRC2(2), BIRC3(2), CASP2(3), CASP3(2), CASP6(5), CASP7(3), CASP9(1), CFLAR(2), CHUK(6), CRADD(1), DAXX(5), FADD(4), GSN(5), LMNA(1), LMNB1(1), LMNB2(8), MAP2K7(2), MAP3K1(6), MAP3K5(6), MAPK8(4), MDM2(2), NFKB1(5), NFKBIA(1), NUMA1(17), PAK2(8), PRKCD(4), PRKDC(28), PSEN2(1), PTK2(8), RB1(18), RELA(2), RIPK1(2), SPTAN1(24), TNFRSF1A(1), TNFRSF1B(2), TRADD(1), TRAF2(2)	50295853	221	145	221	72	29	47	62	35	48	0	0.447	1.000	1.000
258	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AADAT(3), AANAT(1), ACAT2(2), ACMSD(4), AFMID(6), ALDH1A3(1), ALDH1B1(4), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), ALDH9A1(3), AOC2(5), AOC3(5), AOX1(10), ASMT(4), CARM1(5), CAT(4), CYP1A1(2), CYP1A2(5), CYP1B1(5), DDC(7), ECHS1(2), EHHADH(5), GCDH(2), HAAO(1), HADH(4), HADHA(3), HEMK1(1), HSD17B10(1), HSD17B4(5), KMO(1), KYNU(9), LCMT1(2), LCMT2(7), MAOA(1), MAOB(1), METTL2B(4), METTL6(3), NFX1(2), OGDH(10), OGDHL(12), PRMT2(1), PRMT3(6), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(4), TDO2(4), TPH1(2), TPH2(6), WARS(2), WARS2(8)	45967534	199	145	199	66	28	44	62	32	33	0	0.387	1.000	1.000
259	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(2), ADH1B(2), ADH4(3), ADH5(3), ADH6(1), ADH7(2), ADHFE1(4), AGK(3), AGPAT1(2), AGPAT2(3), AGPAT3(3), AGPAT4(2), AGPAT6(2), AKR1A1(1), AKR1B1(2), ALDH1A3(1), ALDH1B1(4), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), ALDH9A1(3), CEL(2), DAK(4), DGAT1(1), DGAT2(2), DGKA(4), DGKB(12), DGKD(7), DGKE(5), DGKG(6), DGKH(4), DGKI(11), DGKQ(7), DGKZ(7), GK(5), GK2(8), GLA(3), GLB1(5), GPAM(8), LCT(17), LIPA(3), LIPC(5), LIPF(1), LIPG(4), LPL(4), PNLIP(4), PNLIPRP1(7), PPAP2A(1), PPAP2B(1)	44508420	197	141	196	63	26	43	50	40	38	0	0.201	1.000	1.000
260	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	47	ACTA1(4), AGT(4), AKT1(2), CALM1(1), CALM2(2), CALM3(2), CALR(2), CAMK1(2), CAMK1G(2), CREBBP(39), CSNK1A1(1), EDN1(1), ELSPBP1(2), F2(3), FGF2(1), GSK3B(3), HAND1(2), HAND2(2), IGF1(1), LIF(2), MAP2K1(5), MAPK14(2), MAPK8(4), MYH2(28), NFATC1(9), NFATC2(15), NFATC3(6), NFATC4(3), NKX2-5(1), NPPA(3), PIK3R1(10), PPP3CA(2), PPP3CB(1), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), RAF1(3), RPS6KB1(5), SYT1(8)	35440055	199	141	198	64	34	43	59	30	32	1	0.185	1.000	1.000
261	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	40	AKT1(2), ASAH1(1), ATF1(3), BRAF(10), CREB1(1), CREB5(8), CREBBP(39), CRKL(3), DAG1(5), EGR1(4), EGR2(5), EGR4(1), ELK1(2), FRS2(2), JUN(1), MAP1B(18), MAP2K4(2), MAP2K7(2), MAPK10(4), MAPK8(4), MAPK8IP1(3), MAPK8IP2(3), MAPK8IP3(8), MAPK9(4), NTRK1(3), OPN1LW(3), PIK3C2G(13), PIK3CD(8), PIK3R1(10), PTPN11(2), RPS6KA3(4), SHC1(3), TH(3)	36969164	184	141	182	49	28	34	50	33	38	1	0.0851	1.000	1.000
262	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	41	AKT1(2), AKT2(3), AKT3(6), BRAF(10), DDIT4(1), EIF4B(7), EIF4EBP1(1), FIGF(1), HIF1A(3), IGF1(1), PDPK1(4), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PRKAA1(4), PRKAA2(4), RHEB(1), RICTOR(9), RPS6KA1(10), RPS6KA2(6), RPS6KA3(4), RPS6KA6(8), RPS6KB1(5), RPS6KB2(2), STK11(7), TSC1(4), TSC2(8), ULK1(8), VEGFB(1), VEGFC(6)	36698593	192	139	189	52	34	42	49	31	36	0	0.0772	1.000	1.000
263	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	CAD(5), CANT1(3), CTPS2(1), DCK(4), DHODH(6), DPYD(16), DPYS(7), ENTPD1(4), ITPA(4), NME2(1), NT5E(1), NUDT2(1), POLB(1), POLD1(11), POLD2(1), POLE(11), POLG(8), POLL(6), POLQ(22), POLR1B(4), POLR2A(11), POLR2B(10), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(3), POLR2G(4), POLR2H(1), POLR2I(1), POLR2J(2), POLR2L(2), POLRMT(6), RRM1(1), RRM2(1), TXNRD1(6), TYMS(2), UCK1(3), UCK2(4), UMPS(2), UNG(2), UPB1(2), UPP1(3)	43605398	186	138	186	61	27	33	59	32	35	0	0.432	1.000	1.000
264	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	32	AKT1(2), APC(27), AR(6), ASAH1(1), BRAF(10), CCL15(1), CCL16(1), DAG1(5), EGFR(19), GNA11(4), GNA15(4), GNAI1(2), ITPKB(5), ITPR1(16), ITPR2(25), ITPR3(10), KCNJ3(11), KCNJ5(3), KCNJ9(1), MAPK10(4), MAPK14(2), PHKA2(9), PIK3CD(8), PIK3R1(10), PITX2(2), PTX3(4), RAF1(3)	38267398	195	137	193	63	30	44	52	39	30	0	0.246	1.000	1.000
265	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	AANAT(1), ACAT2(2), ACMSD(4), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), AOC2(5), AOC3(5), AOX1(10), ASMT(4), CAT(4), CYP19A1(3), CYP1A1(2), CYP1A2(5), CYP2A13(4), CYP2A6(2), CYP2A7(4), CYP2B6(5), CYP2C18(3), CYP2C19(6), CYP2C8(6), CYP2C9(7), CYP2D6(5), CYP2E1(6), CYP2F1(2), CYP2J2(7), CYP3A4(6), CYP3A5(1), CYP3A7(1), CYP4B1(3), CYP51A1(1), DDC(7), ECHS1(2), EHHADH(5), GCDH(2), HAAO(1), HADHA(3), KMO(1), KYNU(9), MAOA(1), MAOB(1), SDS(1), TDO2(4), TPH1(2), WARS(2), WARS2(8)	41837003	186	137	186	66	25	40	60	33	27	1	0.552	1.000	1.000
266	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	64	APAF1(12), BAD(1), BAK1(1), BAX(1), BCL2(1), BCL2L1(2), BCL2L11(1), BID(3), BIRC2(2), BIRC3(2), BIRC5(1), CASP1(2), CASP10(2), CASP2(3), CASP3(2), CASP4(2), CASP6(5), CASP7(3), CASP9(1), CHUK(6), FADD(4), FAS(5), FASLG(1), GZMB(2), HELLS(6), IKBKB(12), IRF1(8), IRF2(8), IRF3(2), IRF4(5), IRF5(3), IRF6(6), IRF7(3), JUN(1), LTA(4), MAP2K4(2), MAP3K1(6), MAPK10(4), MDM2(2), MYC(6), NFKB1(5), NFKBIA(1), NFKBIB(1), NFKBIE(1), PLEKHG5(6), PRF1(4), RELA(2), RIPK1(2), TNFRSF10B(1), TNFRSF1A(1), TNFRSF1B(2), TNFRSF21(6), TNFRSF25(2), TNFSF10(1), TRADD(1), TRAF2(2), TRAF3(6)	42241605	187	136	184	54	35	49	42	22	39	0	0.0676	1.000	1.000
267	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(5), ACSS2(2), ACYP1(1), ADH1A(2), ADH1B(2), ADH4(3), ADH5(3), ADH6(1), ADH7(2), ADHFE1(4), AKR1A1(1), ALDH1A3(1), ALDH1B1(4), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH3B1(3), ALDH3B2(4), ALDH7A1(2), ALDH9A1(3), ALDOA(1), ALDOB(5), ALDOC(4), DLAT(4), DLD(1), ENO1(2), ENO2(1), ENO3(3), FBP2(1), G6PC(2), G6PC2(7), GAPDH(2), GAPDHS(1), GCK(4), GPI(3), HK1(4), HK2(5), HK3(8), LDHA(1), LDHAL6A(2), LDHAL6B(6), LDHB(1), LDHC(4), PDHA1(4), PDHA2(14), PDHB(1), PFKL(6), PFKM(6), PFKP(6), PGAM1(2), PGAM2(4), PGAM4(1), PGK1(2), PGK2(5), PGM1(5), PGM3(1), PKLR(3), TPI1(4)	44194172	183	136	183	76	29	48	45	29	32	0	0.768	1.000	1.000
268	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	69	ADH1A(2), ADH1B(2), ADH4(3), ADH5(3), ADH6(1), ADH7(2), ADHFE1(4), AKR1C1(1), AKR1C4(3), ALDH1A3(1), ALDH3A1(1), ALDH3B1(3), ALDH3B2(4), CYP1A1(2), CYP1A2(5), CYP1B1(5), CYP2B6(5), CYP2C18(3), CYP2C19(6), CYP2C8(6), CYP2C9(7), CYP2E1(6), CYP2F1(2), CYP2S1(1), CYP3A4(6), CYP3A43(2), CYP3A5(1), CYP3A7(1), EPHX1(2), GSTA1(3), GSTA2(1), GSTA3(2), GSTA5(2), GSTK1(2), GSTM1(1), GSTM2(3), GSTM3(1), GSTM4(5), GSTM5(1), GSTP1(1), GSTT1(1), GSTZ1(1), MGST1(1), MGST2(1), MGST3(2), UGT1A1(4), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A9(1), UGT2A1(6), UGT2A3(7), UGT2B10(11), UGT2B11(9), UGT2B15(4), UGT2B17(5), UGT2B28(6), UGT2B4(13), UGT2B7(7)	43717129	204	136	204	82	28	40	68	39	28	1	0.864	1.000	1.000
269	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	56	ALG2(2), BAK1(1), BAX(1), BTK(8), CAD(5), CASP10(2), CASP3(2), CD7(2), CSNK1A1(1), DAXX(5), DEDD(1), DEDD2(5), DIABLO(2), EGFR(19), EPHB2(3), FADD(4), FAF1(2), IL1A(1), MAP2K4(2), MAP2K7(2), MAP3K1(6), MAP3K5(6), MAPK10(4), MAPK8(4), MAPK8IP1(3), MAPK8IP2(3), MAPK8IP3(8), MAPK9(4), MET(4), NFAT5(13), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(1), NFKBIE(1), NFKBIL1(1), NR0B2(1), PFN1(1), PTPN13(13), RALBP1(5), RIPK1(2), ROCK1(19), TNFRSF6B(4), TPX2(5), TRAF2(2)	53450829	191	136	191	61	27	43	59	25	36	1	0.356	1.000	1.000
270	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	30	AKT1(2), AKT2(3), AKT3(6), BCR(2), BTK(8), CD19(4), FLOT1(2), FLOT2(4), GAB1(5), ITPR1(16), ITPR2(25), ITPR3(10), LYN(8), NR0B2(1), PDK1(3), PITX2(2), PLCG2(9), PPP1R13B(2), PREX1(15), PTPRC(19), RPS6KA1(10), RPS6KA2(6), RPS6KA3(4), RPS6KB1(5), SAG(1), SYK(8), TEC(2), VAV1(8)	39121694	190	135	189	69	28	48	44	38	31	1	0.476	1.000	1.000
271	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(3), AKR1D1(3), ARSD(4), ARSE(2), CARM1(5), CYP11B1(6), CYP11B2(4), CYP19A1(3), HEMK1(1), HSD11B2(3), HSD17B1(2), HSD17B2(2), HSD17B3(2), HSD17B7(1), HSD17B8(3), HSD3B1(4), HSD3B2(4), LCMT1(2), LCMT2(7), METTL2B(4), METTL6(3), PRMT2(1), PRMT3(6), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(4), STS(3), SULT1E1(5), SULT2A1(2), UGT1A1(4), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A9(1), UGT2A1(6), UGT2A3(7), UGT2B10(11), UGT2B11(9), UGT2B15(4), UGT2B17(5), UGT2B28(6), UGT2B4(13), UGT2B7(7)	38193915	183	134	183	61	34	33	60	36	20	0	0.433	1.000	1.000
272	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ABL1(8), ACTB(5), ACTG1(3), ARHGEF2(3), CD14(1), CDC42(3), CDH1(5), CTNNB1(6), CTTN(10), FYN(5), HCLS1(2), ITGB1(16), KRT18(1), LY96(2), NCK1(5), NCK2(7), NCL(4), OCLN(1), PRKCA(7), ROCK1(19), ROCK2(10), TLR4(16), TLR5(4), TUBA1B(5), TUBA3C(10), TUBA3D(3), TUBA3E(7), TUBA4A(1), TUBA8(2), TUBAL3(4), TUBB(3), TUBB1(3), TUBB2A(1), TUBB3(1), TUBB6(4), TUBB8(2), WAS(2), WASL(2), YWHAQ(3), YWHAZ(2)	39643784	198	134	195	73	30	47	58	25	37	1	0.513	1.000	1.000
273	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ABL1(8), ACTB(5), ACTG1(3), ARHGEF2(3), CD14(1), CDC42(3), CDH1(5), CTNNB1(6), CTTN(10), FYN(5), HCLS1(2), ITGB1(16), KRT18(1), LY96(2), NCK1(5), NCK2(7), NCL(4), OCLN(1), PRKCA(7), ROCK1(19), ROCK2(10), TLR4(16), TLR5(4), TUBA1B(5), TUBA3C(10), TUBA3D(3), TUBA3E(7), TUBA4A(1), TUBA8(2), TUBAL3(4), TUBB(3), TUBB1(3), TUBB2A(1), TUBB3(1), TUBB6(4), TUBB8(2), WAS(2), WASL(2), YWHAQ(3), YWHAZ(2)	39643784	198	134	195	73	30	47	58	25	37	1	0.513	1.000	1.000
274	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	22	IMPA1(2), INPP1(2), INPP4A(8), INPP4B(11), INPP5A(3), INPPL1(9), ITPKB(5), MIOX(4), OCRL(4), PIK3C2A(6), PIK3C2B(10), PIK3C2G(13), PIK3CB(7), PIK3CG(20), PLCB1(21), PLCB2(7), PLCB3(8), PLCB4(17), PLCD1(4), PLCG1(8), PLCG2(9)	32377525	178	134	173	48	33	31	55	31	28	0	0.0607	1.000	1.000
275	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	42	CBL(3), CD28(3), CD3D(1), CSK(1), CTLA4(2), DAG1(5), EPHB2(3), GRAP2(2), ITK(3), ITPKB(5), LAT(3), LCK(5), LCP2(2), NCK1(5), NFAT5(13), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(1), NFKBIE(1), NFKBIL1(1), PAK1(3), PAK2(8), PAK3(4), PAK4(1), PAK6(5), PAK7(9), PLCG1(8), PTPRC(19), RAF1(3), RASGRP1(8), RASGRP2(6), RASGRP3(8), RASGRP4(3), SOS1(9), SOS2(11), VAV1(8), ZAP70(2)	40747494	185	134	185	65	23	36	58	27	41	0	0.670	1.000	1.000
276	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(3), ALPL(4), ALPP(3), ALPPL2(7), ASCC3(12), ATP13A2(2), DDX18(3), DDX19A(2), DDX23(3), DDX4(4), DDX41(5), DDX47(2), DDX50(1), DDX51(3), DDX52(6), DDX54(5), DDX55(3), DDX56(4), DHFR(3), DHX58(2), ENTPD7(4), EP400(19), ERCC2(5), ERCC3(5), FPGS(2), GGH(3), IFIH1(6), MOV10L1(5), NUDT5(2), NUDT8(1), QDPR(3), RAD54B(6), RAD54L(5), RUVBL2(2), SETX(12), SKIV2L2(4), SMARCA2(13), SMARCA5(2)	47813003	176	131	176	54	22	34	58	35	27	0	0.388	1.000	1.000
277	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG1(3), ACTG2(5), ACTR2(1), AKT1(2), ANGPTL2(3), CDC42(3), CFL1(2), FLNA(23), FLNC(15), FSCN1(2), FSCN2(1), FSCN3(6), GDI1(4), GDI2(5), LIMK1(5), MYH2(28), MYLK(8), MYLK2(5), PAK1(3), PAK2(8), PAK3(4), PAK4(1), PAK6(5), PAK7(9), PFN1(1), RHO(3), ROCK1(19), ROCK2(10), VASP(1), WASF1(3), WASL(2)	36437833	190	131	190	75	31	45	53	28	33	0	0.677	1.000	1.000
278	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	23	BRCA1(12), CARM1(5), CCND1(4), CREBBP(39), ERCC3(5), ESR1(6), GRIP1(11), GTF2A1(3), GTF2E1(7), GTF2F1(4), HDAC1(1), HDAC2(3), HDAC3(3), HDAC4(10), HDAC5(3), HDAC6(8), NCOR2(24), NR0B1(5), NRIP1(9), PELP1(2), POLR2A(11), TBP(2)	30546205	177	130	176	62	19	33	53	37	34	1	0.575	1.000	1.000
279	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	37	AKT1(2), AKT2(3), AKT3(6), BAD(1), BCR(2), BLNK(5), BTK(8), CD19(4), CSK(1), DAG1(5), EPHB2(3), ITPKB(5), LYN(8), MAP2K1(5), MAP2K2(6), NFAT5(13), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(1), NFKBIE(1), NFKBIL1(1), PI3(2), PIK3CD(8), PIK3R1(10), PLCG2(9), PPP1R13B(2), RAF1(3), SERPINA4(7), SHC1(3), SOS1(9), SOS2(11), SYK(8), VAV1(8)	38028694	171	129	171	56	34	31	45	28	32	1	0.335	1.000	1.000
280	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	46	AADAT(3), AASDHPPT(3), AASS(3), ACAT2(2), AKR1B10(4), ALDH1A3(1), ALDH1B1(4), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), ALDH9A1(3), BBOX1(1), DLST(6), DOT1L(9), ECHS1(2), EHHADH(5), EHMT1(7), EHMT2(11), GCDH(2), HADH(4), HADHA(3), HSD17B10(1), HSD17B4(5), HSD3B7(2), OGDH(10), OGDHL(12), PIPOX(2), PLOD1(3), PLOD2(7), PLOD3(4), RDH11(2), RDH12(4), SETD1A(11), SETD7(4), SETDB1(10), SHMT1(1), SHMT2(2), SPCS1(2), SPCS3(1), SUV39H1(4), SUV39H2(2), TMLHE(2)	39947494	170	127	170	65	33	30	47	33	27	0	0.653	1.000	1.000
281	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(9), ATP4A(6), ATP4B(2), ATP5A1(1), ATP5B(2), ATP5C1(1), ATP5F1(1), ATP5G1(1), ATP5G2(2), ATP5G3(1), ATP5H(1), ATP5L(1), ATP5O(1), ATP6AP1(2), ATP6V0A1(4), ATP6V0A2(3), ATP6V0A4(6), ATP6V0B(1), ATP6V0C(1), ATP6V0D1(2), ATP6V0D2(3), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(3), ATP6V1C1(4), ATP6V1C2(3), ATP6V1D(2), ATP6V1E1(2), ATP6V1E2(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(3), ATP6V1H(3), COX10(3), COX15(4), COX17(2), COX4I2(1), COX5A(2), COX5B(1), COX7B2(2), COX8A(1), CYC1(3), LHPP(1), NDUFA1(1), NDUFA12(1), NDUFA13(3), NDUFA2(1), NDUFA3(1), NDUFA5(3), NDUFA7(2), NDUFA9(2), NDUFB10(1), NDUFB2(2), NDUFB3(2), NDUFB4(1), NDUFB6(1), NDUFB8(2), NDUFB9(2), NDUFS1(1), NDUFS2(3), NDUFS3(2), NDUFS4(1), NDUFS5(3), NDUFS7(2), NDUFS8(2), NDUFV1(3), NDUFV3(1), PPA1(1), SDHA(7), SDHB(1), SDHC(1), TCIRG1(8), UQCRC1(1), UQCRC2(1), UQCRFS1(4)	42404427	166	125	165	46	17	36	56	31	26	0	0.138	1.000	1.000
282	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(35), B3GALT4(4), CDR1(7), DGKI(11), IL6ST(4), MRPL19(3), PIGK(6), RPL10(3), RPL12(1), RPL13A(2), RPL15(1), RPL17(1), RPL18A(1), RPL22(1), RPL23(1), RPL26(1), RPL27(1), RPL28(1), RPL3(5), RPL31(2), RPL32(1), RPL36(2), RPL37(2), RPL39(1), RPL3L(1), RPL4(1), RPL5(2), RPL6(3), RPL7A(1), RPL8(1), RPLP0(4), RPLP2(2), RPS10(2), RPS13(2), RPS15(1), RPS19(1), RPS20(1), RPS21(1), RPS23(1), RPS25(2), RPS26(1), RPS27A(1), RPS28(1), RPS3(1), RPS5(1), RPS6KA1(10), RPS6KA2(6), RPS6KA3(4), RPS6KA6(8), RPS6KB1(5), RPS6KB2(2), SLC36A2(3), TBC1D10C(3), TSPAN9(1), UBA52(3), UBB(1), UBC(5)	39813299	179	125	179	74	21	38	68	24	28	0	0.945	1.000	1.000
283	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ADH1A(2), ADH1B(2), ADH4(3), ADH5(3), ADH6(1), ADH7(2), ADHFE1(4), ALDH1A3(1), ALDH3A1(1), ALDH3B1(3), ALDH3B2(4), AOC2(5), AOC3(5), AOX1(10), CARM1(5), COMT(1), DBH(8), DCT(4), DDC(7), ECH1(2), ESCO1(4), ESCO2(4), FAH(2), GOT1(1), GOT2(3), GSTZ1(1), HEMK1(1), HGD(4), HPD(3), LCMT1(2), LCMT2(7), MAOA(1), MAOB(1), METTL2B(4), METTL6(3), PNMT(1), PRMT2(1), PRMT3(6), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(4), SH3GLB1(2), TAT(1), TH(3), TPO(11), TYR(8), TYRP1(4)	45187717	163	124	162	53	27	40	48	21	27	0	0.247	1.000	1.000
284	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(10), COL4A2(9), COL4A3(19), COL4A4(14), COL4A5(14), COL4A6(4), F10(4), F11(2), F12(2), F2(3), F2R(4), F5(20), F8(8), F9(9), FGA(10), FGB(4), FGG(6), KLKB1(7), PROC(2), PROS1(9), SERPINC1(4), SERPING1(5)	33727835	169	124	168	55	16	52	46	29	26	0	0.611	1.000	1.000
285	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(2), ADH1B(2), ADH4(3), ADH6(1), ADH7(2), ADHFE1(4), AGPAT1(2), AGPAT2(3), AGPAT3(3), AGPAT4(2), AKR1A1(1), AKR1B1(2), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), CEL(2), DGAT1(1), DGKA(4), DGKB(12), DGKD(7), DGKE(5), DGKG(6), DGKH(4), DGKQ(7), DGKZ(7), GK(5), GLA(3), GLB1(5), LCT(17), LIPC(5), LIPF(1), LIPG(4), LPL(4), PNLIP(4), PNLIPRP1(7), PPAP2A(1), PPAP2B(1)	36570399	162	123	161	54	21	32	42	30	37	0	0.323	1.000	1.000
286	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	41	BCL2(1), CHUK(6), DAXX(5), EGF(9), EGFR(19), ETS1(4), ETS2(7), FOS(6), HOXA7(4), IKBKB(12), JUN(1), MAP2K1(5), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAP2K7(2), MAP3K1(6), MAP3K5(6), MAPK13(3), MAPK14(2), MAPK8(4), NFKB1(5), NFKBIA(1), PRKCA(7), PRKCD(4), PRKCE(3), PRKCG(12), PRKCH(4), PRKCQ(8), RAF1(3), RELA(2), RIPK1(2), SP1(3), TNFRSF1A(1), TNFRSF1B(2), TRAF2(2)	36684011	168	123	168	67	28	34	53	26	26	1	0.786	1.000	1.000
287	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BTK(8), CALM1(1), CALM2(2), CALM3(2), ELK1(2), FCER1A(4), FOS(6), JUN(1), LYN(8), MAP2K1(5), MAP2K4(2), MAP2K7(2), MAP3K1(6), MAPK8(4), NFATC1(9), NFATC2(15), NFATC3(6), NFATC4(3), PAK2(8), PIK3R1(10), PLA2G4A(3), PLCG1(8), PPP3CA(2), PPP3CB(1), RAF1(3), SHC1(3), SOS1(9), SYK(8), SYT1(8), VAV1(8)	30228030	157	122	157	40	29	25	46	29	27	1	0.111	1.000	1.000
288	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	37	AKT1(2), ATF2(1), CDC42(3), DLD(1), DUSP10(3), DUSP4(1), DUSP8(1), GAB1(5), GADD45A(1), GCK(4), IL1R1(4), JUN(1), MAP2K4(2), MAP2K5(3), MAP2K7(2), MAP3K1(6), MAP3K10(6), MAP3K11(2), MAP3K12(8), MAP3K13(15), MAP3K2(1), MAP3K3(3), MAP3K4(14), MAP3K5(6), MAP3K7(8), MAP3K9(9), MAPK10(4), MAPK7(6), MAPK8(4), MAPK9(4), MYEF2(7), NFATC3(6), NR2C2(1), PAPPA(13), SHC1(3), TRAF6(3), ZAK(5)	37764870	168	122	165	44	26	38	57	25	22	0	0.124	1.000	1.000
289	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	34	CALM1(1), CALM2(2), CALM3(2), CAMK1(2), CAMK1G(2), ELK1(2), FPR1(7), GNA15(4), GNB1(3), MAP2K1(5), MAP2K2(6), MAP2K3(4), MAP2K6(1), MAP3K1(6), MAPK14(2), NCF1(2), NCF2(6), NFATC1(9), NFATC2(15), NFATC3(6), NFATC4(3), NFKB1(5), NFKBIA(1), PAK1(3), PIK3C2G(13), PLCB1(21), PPP3CA(2), PPP3CB(1), RAF1(3), RELA(2), SYT1(8)	27927977	149	121	147	49	32	23	51	23	20	0	0.454	1.000	1.000
290	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	ALOX12(3), ALOX12B(4), ALOX15B(5), ALOX5(5), CBR3(1), CYP2B6(5), CYP2C18(3), CYP2C19(6), CYP2C8(6), CYP2C9(7), CYP2E1(6), CYP2J2(7), CYP2U1(1), CYP4A11(13), CYP4A22(9), CYP4F2(7), CYP4F3(3), DHRS4(2), EPHX2(4), GGT1(4), GPX2(1), GPX5(2), GPX6(4), GPX7(1), LTA4H(1), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PTGDS(2), PTGES2(1), PTGIS(7), PTGS1(7), PTGS2(4), TBXAS1(5)	29595932	153	121	153	52	20	32	47	25	28	1	0.274	1.000	1.000
291	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT1(2), AKT2(3), AKT3(6), ANKRD6(3), APC(27), AXIN1(11), AXIN2(7), CER1(1), CSNK1A1(1), CTNNB1(6), DACT1(6), DKK1(2), DKK2(5), DKK3(2), DVL1(7), FSTL1(3), GSK3A(2), GSK3B(3), LRP1(34), MVP(5), NKD1(8), NKD2(3), PIN1(1), PTPRA(4), SENP2(3), SFRP1(2), TSHB(2), WIF1(1)	30754359	160	121	159	55	22	38	42	32	25	1	0.449	1.000	1.000
292	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	ACHE(2), AGPAT1(2), AGPAT2(3), AGPAT3(3), AGPAT4(2), AGPAT6(2), CDIPT(1), CDS1(3), CDS2(3), CHAT(9), CHKB(1), CHPT1(2), CRLS1(1), DGKA(4), DGKB(12), DGKD(7), DGKE(5), DGKG(6), DGKH(4), DGKI(11), DGKQ(7), DGKZ(7), ESCO1(4), ESCO2(4), ETNK1(1), ETNK2(3), GNPAT(3), GPAM(8), GPD1(1), GPD2(5), LCAT(2), LYPLA1(1), LYPLA2(1), PCYT1A(2), PCYT1B(2), PHOSPHO1(1), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PLD1(15), PLD2(1), PPAP2A(1), PPAP2B(1), PTDSS1(7), PTDSS2(2), SH3GLB1(2)	49774432	181	120	180	55	19	37	53	29	43	0	0.248	1.000	1.000
293	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	21	ADRB1(3), AKT1(2), APC(27), ASAH1(1), DAG1(5), DLG4(3), EPHB2(3), GNAI1(2), ITPR1(16), ITPR2(25), ITPR3(10), KCNJ3(11), KCNJ5(3), KCNJ9(1), PITX2(2), PTX3(4), RHO(3), RYR1(34)	33910438	155	120	154	60	30	35	38	25	27	0	0.469	1.000	1.000
294	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	38	CALM1(1), CALM2(2), CALM3(2), CD3D(1), ELK1(2), FOS(6), FYN(5), JUN(1), LAT(3), LCK(5), MAP2K1(5), MAP2K4(2), MAP3K1(6), MAPK8(4), NFATC1(9), NFATC2(15), NFATC3(6), NFATC4(3), NFKB1(5), NFKBIA(1), PIK3R1(10), PLCG1(8), PPP3CA(2), PPP3CB(1), PRKCA(7), PTPN7(4), RAF1(3), RELA(2), SHC1(3), SOS1(9), SYT1(8), VAV1(8), ZAP70(2)	32524611	151	118	151	40	30	26	44	22	29	0	0.0956	1.000	1.000
295	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	26	ARHGDIB(1), CASP10(2), CASP3(2), CASP6(5), CASP7(3), CFLAR(2), DAXX(5), FADD(4), FAF1(2), JUN(1), LMNA(1), LMNB1(1), LMNB2(8), MAP2K4(2), MAP3K1(6), MAP3K7(8), MAPK8(4), PAK1(3), PAK2(8), PRKDC(28), PTPN13(13), RB1(18), RIPK2(6), SPTAN1(24)	30163874	157	116	156	37	18	34	45	23	37	0	0.0920	1.000	1.000
296	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ADH1A(2), ADH1B(2), ADH4(3), ADH6(1), ADH7(2), ADHFE1(4), AKR1A1(1), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH3B1(3), ALDH3B2(4), ALDH9A1(3), ALDOA(1), ALDOB(5), ALDOC(4), DLAT(4), DLD(1), ENO1(2), ENO2(1), ENO3(3), FBP2(1), G6PC(2), GAPDH(2), GCK(4), GPI(3), HK1(4), HK2(5), HK3(8), LDHA(1), LDHB(1), LDHC(4), PDHA1(4), PDHA2(14), PDHB(1), PFKM(6), PFKP(6), PGAM1(2), PGK1(2), PGM1(5), PGM3(1), PKLR(3), TPI1(4)	37124672	150	116	150	57	22	39	37	25	27	0	0.610	1.000	1.000
297	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ADH1A(2), ADH1B(2), ADH4(3), ADH6(1), ADH7(2), ADHFE1(4), AKR1A1(1), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH3B1(3), ALDH3B2(4), ALDH9A1(3), ALDOA(1), ALDOB(5), ALDOC(4), DLAT(4), DLD(1), ENO1(2), ENO2(1), ENO3(3), FBP2(1), G6PC(2), GAPDH(2), GCK(4), GPI(3), HK1(4), HK2(5), HK3(8), LDHA(1), LDHB(1), LDHC(4), PDHA1(4), PDHA2(14), PDHB(1), PFKM(6), PFKP(6), PGAM1(2), PGK1(2), PGM1(5), PGM3(1), PKLR(3), TPI1(4)	37124672	150	116	150	57	22	39	37	25	27	0	0.610	1.000	1.000
298	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	A4GALT(1), B3GALNT1(1), B3GALT1(2), B3GALT2(2), B3GALT4(4), B3GALT5(1), B3GNT1(3), B3GNT2(1), B3GNT3(5), B3GNT5(2), B4GALNT1(3), B4GALT1(1), B4GALT2(5), B4GALT3(1), B4GALT4(2), B4GALT6(2), FUT2(2), FUT3(3), FUT5(4), FUT6(2), FUT7(1), FUT9(11), GBGT1(4), GCNT2(5), PIGA(2), PIGB(3), PIGC(2), PIGG(6), PIGK(6), PIGN(3), PIGO(4), PIGP(1), PIGQ(4), PIGS(2), PIGT(2), PIGU(1), PIGV(1), PIGX(2), PIGZ(2), ST3GAL1(2), ST3GAL2(1), ST3GAL3(4), ST3GAL4(1), ST3GAL5(6), ST3GAL6(4), ST6GALNAC3(8), ST6GALNAC5(5), ST6GALNAC6(4), ST8SIA1(3), ST8SIA5(7), UGCG(1)	36951387	155	116	153	60	29	37	52	18	19	0	0.471	1.000	1.000
299	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(17), AR(6), ESR1(6), ESR2(1), ESRRA(5), HNF4A(7), NPM1(2), NR0B1(5), NR1D1(1), NR1D2(3), NR1H2(2), NR1H3(1), NR1I2(4), NR1I3(1), NR2C2(1), NR2E1(8), NR2F1(3), NR2F2(9), NR2F6(1), NR3C1(6), NR4A1(2), NR4A2(4), NR5A2(5), PGR(5), PPARA(2), PPARD(1), PPARG(1), RARA(4), RARB(6), RARG(11), ROR1(9), RORA(3), RORC(3), RXRA(5), RXRB(3), RXRG(7), THRA(6), THRB(1), VDR(2)	31972831	169	116	167	48	30	29	59	24	26	1	0.102	1.000	1.000
300	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(2), AGPAT1(2), AGPAT2(3), AGPAT3(3), AGPAT4(2), AGPS(5), CDIPT(1), CDS1(3), CDS2(3), CHAT(9), CHKB(1), CLC(3), CPT1B(4), DGKA(4), DGKB(12), DGKD(7), DGKE(5), DGKG(6), DGKH(4), DGKQ(7), DGKZ(7), ETNK1(1), GNPAT(3), GPD1(1), GPD2(5), LCAT(2), LGALS13(1), LYPLA1(1), LYPLA2(1), PAFAH1B1(1), PAFAH2(1), PCYT1A(2), PCYT1B(2), PLA2G1B(2), PLA2G2A(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PLCB2(7), PLCG1(8), PLCG2(9), PPAP2A(1), PPAP2B(1)	37943344	153	115	152	51	20	25	45	26	37	0	0.365	1.000	1.000
301	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(15), ACACB(20), ACAT2(2), ACOT12(3), ACSS1(5), ACSS2(2), ACYP1(1), AKR1B1(2), ALDH1A3(1), ALDH1B1(4), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), ALDH9A1(3), DLAT(4), DLD(1), GLO1(2), GRHPR(1), HAGH(1), LDHA(1), LDHAL6A(2), LDHAL6B(6), LDHB(1), LDHC(4), LDHD(1), MDH1(1), MDH2(1), ME1(2), ME2(3), ME3(7), PC(14), PCK1(1), PCK2(4), PDHA1(4), PDHA2(14), PDHB(1), PKLR(3)	35530493	143	114	143	55	30	26	40	27	20	0	0.785	1.000	1.000
302	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	32	BLNK(5), BTK(8), CALM1(1), CALM2(2), CALM3(2), CD79A(1), ELK1(2), FOS(6), JUN(1), LYN(8), MAP2K1(5), MAP3K1(6), MAPK14(2), MAPK8(4), NFATC1(9), NFATC2(15), NFATC3(6), NFATC4(3), PLCG1(8), PPP3CA(2), PPP3CB(1), PRKCA(7), RAF1(3), SHC1(3), SOS1(9), SYK(8), SYT1(8), VAV1(8)	28435577	143	113	143	35	29	24	41	25	23	1	0.0402	1.000	1.000
303	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(2), AKR1B10(4), B4GALT1(1), B4GALT2(5), G6PC(2), G6PC2(7), GAA(3), GALK1(1), GALK2(2), GALT(2), GANC(6), GCK(4), GLA(3), GLB1(5), HK1(4), HK2(5), HK3(8), HSD3B7(2), LALBA(1), LCT(17), MGAM(32), PFKL(6), PFKM(6), PFKP(6), PGM1(5), PGM3(1), RDH11(2), RDH12(4), UGP2(2)	29300594	148	113	147	38	26	32	45	21	23	1	0.0230	1.000	1.000
304	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA2(1), ACADL(4), ACADM(3), ACADS(2), ACADSB(3), ACADVL(4), ACAT2(2), ACOX1(1), ACOX3(2), ACSL1(3), ACSL3(3), ACSL4(6), ACSL5(5), ACSL6(3), ADH1A(2), ADH1B(2), ADH4(3), ADH5(3), ADH6(1), ADH7(2), ADHFE1(4), ALDH1A3(1), ALDH1B1(4), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), ALDH9A1(3), CPT1A(6), CPT1B(4), CPT1C(8), CPT2(7), CYP4A11(13), CYP4A22(9), ECHS1(2), EHHADH(5), GCDH(2), HADH(4), HADHA(3), HADHB(4), HSD17B10(1), HSD17B4(5)	37199236	146	113	146	50	14	36	39	32	25	0	0.485	1.000	1.000
305	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(2), AKT2(3), AKT3(6), ARHGEF11(4), BCL2(1), CDC42(3), DLG4(3), GNA13(2), LPA(16), MAP2K4(2), MAP3K1(6), MAP3K5(6), MAPK8(4), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(1), NFKBIE(1), NFKBIL1(1), PDK1(3), PHKA2(9), PI3(2), PIK3CB(7), PLD1(15), PLD2(1), PLD3(2), PTK2(8), RDX(1), ROCK1(19), ROCK2(10), SERPINA4(7), SRF(1), TBXA2R(1)	37381120	158	113	158	58	12	41	50	27	28	0	0.724	1.000	1.000
306	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(8), AKT1(2), AKT2(3), AKT3(6), DAG1(5), ITPKB(5), ITPR1(16), ITPR2(25), ITPR3(10), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(1), NFKBIE(1), NFKBIL1(1), PDK1(3), PHKA2(9), PIK3CB(7), PITX2(2), PLD1(15), PLD2(1), PLD3(2), VN1R1(2)	34047169	135	112	135	52	15	43	31	25	21	0	0.510	1.000	1.000
307	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOA(1), ALDOB(5), ALDOC(4), DLAT(4), DLD(1), ENO1(2), ENO2(1), ENO3(3), FBP2(1), G6PC(2), GAPDH(2), GAPDHS(1), GCK(4), GOT1(1), GOT2(3), GPI(3), HK1(4), HK2(5), HK3(8), LDHA(1), LDHAL6B(6), LDHB(1), LDHC(4), MDH1(1), MDH2(1), PC(14), PCK1(1), PDHA1(4), PDHA2(14), PDHB(1), PDHX(4), PFKL(6), PFKM(6), PFKP(6), PGAM1(2), PGAM2(4), PGK1(2), PGK2(5), PKLR(3), TNFAIP1(4), TPI1(4)	32250973	149	110	149	56	25	39	39	24	22	0	0.450	1.000	1.000
308	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	33	ADCY1(21), CALM1(1), CALM2(2), CALM3(2), CREB1(1), ELK1(2), FOS(6), GNAI1(2), GNAS(12), GNB1(3), JUN(1), MAP2K1(5), NFATC1(9), NFATC2(15), NFATC3(6), NFATC4(3), PLCG1(8), PPP3CA(2), PPP3CB(1), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PRKCA(7), RAF1(3), RPS6KA3(4), SYT1(8)	26244007	140	110	139	36	35	26	40	22	17	0	0.0277	1.000	1.000
309	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	ANKHD1(17), EEF1A2(3), EEF1B2(1), EEF1D(1), EEF1G(2), EEF2(5), EEF2K(6), EIF1AX(1), EIF2AK1(8), EIF2AK2(1), EIF2AK3(7), EIF2B1(1), EIF2B2(3), EIF2B3(4), EIF2B4(4), EIF2B5(4), EIF2S1(2), EIF2S2(6), EIF2S3(1), EIF4A1(3), EIF4A2(2), EIF4E(1), EIF4EBP1(1), EIF4G1(19), EIF4G3(9), EIF5(3), EIF5A(5), EIF5B(6), ETF1(3), GSPT2(6), PABPC1(1), PABPC3(7), PAIP1(5), SLC35A4(1)	33334084	149	110	148	41	16	32	49	28	24	0	0.286	1.000	1.000
310	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	30	ACTA1(4), CRK(2), CRKL(3), DOCK1(15), ELK1(2), FOS(6), GAB1(5), HGF(12), ITGA1(4), ITGB1(16), JUN(1), MAP2K1(5), MAP2K2(6), MAP4K1(4), MAPK8(4), MET(4), PAK1(3), PIK3R1(10), PTK2(8), PTK2B(4), PTPN11(2), PXN(2), RAF1(3), RAP1B(3), SOS1(9), STAT3(6)	28841107	143	109	140	35	23	21	45	31	23	0	0.0943	1.000	1.000
311	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	27	EGFR(19), ELK1(2), GNAS(12), GNB1(3), IGF1R(13), ITGB1(16), KLK2(2), MAP2K1(5), MAP2K2(6), MKNK1(1), MKNK2(2), MYC(6), NGFR(1), PDGFRA(14), PTPRR(5), RAF1(3), RPS6KA1(10), RPS6KA5(5), SHC1(3), SOS1(9), STAT3(6)	24297470	143	108	140	33	36	27	46	18	16	0	0.0155	1.000	1.000
312	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(3), AARS2(5), CARS(4), CARS2(1), DARS(5), DARS2(3), EARS2(4), EPRS(4), FARS2(4), FARSA(1), FARSB(7), GARS(1), HARS(1), HARS2(3), IARS(11), IARS2(3), KARS(3), LARS(5), LARS2(2), MARS(2), MARS2(5), MTFMT(4), NARS(2), NARS2(2), PARS2(5), QARS(5), RARS(1), RARS2(3), SARS(1), TARS(6), TARS2(4), VARS(6), VARS2(4), WARS(2), WARS2(8), YARS(7), YARS2(4)	41248531	141	108	141	38	16	29	47	28	21	0	0.154	1.000	1.000
313	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	30	ACTR2(1), AKT1(2), ANGPTL2(3), DAG1(5), DGKA(4), ETFA(3), GCA(2), ITGA9(3), ITPKB(5), ITPR1(16), ITPR2(25), ITPR3(10), MAP2K1(5), NR1I3(1), PAK1(3), PDE3A(18), PDE3B(4), PI3(2), PIK3C2G(13), PIK3CD(8), PIK3R1(10), PSME1(1), RIPK3(1), SGCB(3), VASP(1)	34730959	149	108	148	57	18	35	39	26	31	0	0.808	1.000	1.000
314	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	27	ARHGDIB(1), BAG4(6), CASP2(3), CASP3(2), CRADD(1), FADD(4), JUN(1), LMNA(1), LMNB1(1), LMNB2(8), MADD(10), MAP2K4(2), MAP3K1(6), MAP3K7(8), MAPK8(4), PAK1(3), PAK2(8), PRKDC(28), RB1(18), RIPK1(2), SPTAN1(24), TNFRSF1A(1), TRADD(1), TRAF2(2)	28714380	145	108	144	41	19	26	47	23	30	0	0.312	1.000	1.000
315	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	35	AGT(4), AGTR2(2), CALM1(1), CALM2(2), CALM3(2), CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), CDK5(3), F2(3), FYN(5), GNA11(4), GNAI1(2), GNB1(3), JAK2(5), MAP2K1(5), MAP2K2(6), MAPK14(2), MAPK8(4), MAPT(8), MYLK(8), PLCG1(8), PRKCA(7), PTK2B(4), RAF1(3), SHC1(3), SOS1(9), STAT1(7), STAT3(6), STAT5A(3), SYT1(8)	30749051	138	107	138	49	31	32	42	20	13	0	0.345	1.000	1.000
316	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(3), AARS2(5), ABAT(6), ACY3(3), ADSL(5), ADSS(4), ADSSL1(6), AGXT(2), AGXT2(5), ASL(2), ASNS(5), ASPA(4), ASRGL1(1), ASS1(2), CAD(5), CRAT(6), DARS(5), DARS2(3), DDO(1), DLAT(4), DLD(1), GAD1(4), GAD2(7), GOT1(1), GOT2(3), GPT(1), GPT2(3), NARS(2), NARS2(2), PC(14), PDHA1(4), PDHA2(14), PDHB(1)	28751414	134	107	134	44	19	34	42	20	19	0	0.294	1.000	1.000
317	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAD(2), ALAS2(5), BLVRA(3), COX10(3), COX15(4), CP(8), CPOX(1), EARS2(4), EPRS(4), FECH(1), FTMT(6), GUSB(5), HCCS(2), HMOX1(1), HMOX2(1), MMAB(2), PPOX(1), UGT1A1(4), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A9(1), UGT2A1(6), UGT2A3(7), UGT2B10(11), UGT2B11(9), UGT2B15(4), UGT2B17(5), UGT2B28(6), UGT2B4(13), UGT2B7(7), UROD(1), UROS(4)	32129286	144	107	144	59	17	22	57	35	13	0	0.961	1.000	1.000
318	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	23	CSNK2A1(7), EGF(9), EGFR(19), ELK1(2), FOS(6), JAK1(11), JUN(1), MAP2K1(5), MAP2K4(2), MAP3K1(6), MAPK8(4), PIK3R1(10), PLCG1(8), PRKCA(7), RAF1(3), SHC1(3), SOS1(9), SRF(1), STAT1(7), STAT3(6), STAT5A(3)	24928734	129	106	129	32	17	28	38	21	24	1	0.0604	1.000	1.000
319	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2A1(3), GTF2A1L(8), GTF2A2(1), GTF2B(1), GTF2E1(7), GTF2F1(4), GTF2F2(3), GTF2H1(3), GTF2H3(2), GTF2H4(3), GTF2I(4), GTF2IRD1(5), STON1(6), TAF1(13), TAF10(4), TAF13(1), TAF1L(25), TAF2(8), TAF4(5), TAF4B(5), TAF5(7), TAF5L(4), TAF6(5), TAF6L(2), TAF7(2), TAF7L(4), TAF9(3), TBPL1(2), TBPL2(1)	27383127	141	106	140	51	18	32	38	28	25	0	0.791	1.000	1.000
320	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(1), ARHGAP1(4), ARHGAP4(9), ARHGAP5(10), ARHGAP6(8), ARHGEF1(9), ARHGEF11(4), ARHGEF5(4), ARPC1B(3), ARPC2(2), ARPC3(1), ARPC4(1), BAIAP2(2), CFL1(2), DIAPH1(7), GSN(5), LIMK1(5), MYLK(8), OPHN1(6), PFN1(1), PIP5K1A(4), PIP5K1B(8), PPP1R12B(4), ROCK1(19), TLN1(24), VCL(6)	34447041	157	106	157	64	24	35	47	32	19	0	0.918	1.000	1.000
321	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	ARNTL(2), AZIN1(3), BTG1(1), CBX3(2), CEBPB(1), CLOCK(6), CRY1(6), CRY2(3), DAZAP2(2), DNAJA1(3), EIF4G2(9), ETV6(6), G0S2(1), GFRA1(8), GSTM3(1), GSTP1(1), HERPUD1(5), HSPA8(10), IDI1(1), KLF9(1), MYF6(2), NCKAP1(8), NCOA4(7), NR1D2(3), PER1(7), PER2(2), PPP1R3C(2), PPP2CB(3), SF3A3(2), SUMO3(1), TUBB3(1), UCP3(5), UGP2(2), VAPA(1), ZFR(5)	27841024	123	105	123	43	16	23	45	23	16	0	0.804	1.000	1.000
322	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(9), GABBR1(3), GPRC5A(2), GPRC5B(2), GPRC5C(3), GPRC5D(1), GRM1(29), GRM2(10), GRM3(29), GRM4(2), GRM5(12), GRM7(19), GRM8(23)	15909035	144	105	142	45	31	28	43	29	13	0	0.0832	1.000	1.000
323	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	33	ACTA1(4), ACTN1(4), ACTN2(11), BCAR1(3), BCR(2), CAPN1(3), CAPNS1(2), CAPNS2(2), CAV1(1), CRKL(3), CSK(1), FYN(5), ITGA1(4), ITGB1(16), JUN(1), MAP2K1(5), MAP2K2(6), MAPK8(4), PPP1R12B(4), PTK2(8), PXN(2), RAF1(3), ROCK1(19), SHC1(3), SOS1(9), TLN1(24), VCL(6), ZYX(2)	35055940	157	105	156	44	28	26	57	26	20	0	0.178	1.000	1.000
324	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	69	CALR(2), CANX(3), CD4(1), CD74(3), CD8A(2), CD8B(2), CIITA(12), CREB1(1), CTSS(4), HLA-C(5), HLA-DMB(1), HLA-DOA(3), HLA-DOB(3), HLA-DQA2(3), HLA-DQB1(2), HLA-DRA(1), HLA-DRB1(2), HLA-E(1), HLA-F(4), HLA-G(2), HSP90AA1(9), HSP90AB1(8), HSPA5(4), IFI30(1), IFNA10(1), IFNA14(1), IFNA16(4), IFNA17(3), IFNA2(1), IFNA21(2), IFNA4(4), IFNA6(1), IFNA8(3), KIR2DL3(1), KIR3DL1(4), KIR3DL3(3), KLRC1(1), KLRC2(1), KLRC3(3), KLRC4(1), LGMN(5), LTA(4), NFYC(2), PSME1(1), PSME2(2), RFX5(4), RFXAP(2), TAP1(6), TAP2(3), TAPBP(4)	33631810	146	104	145	53	16	40	42	21	27	0	0.491	1.000	1.000
325	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	23	ARNT(8), EIF1(2), EIF2B1(1), EIF2B2(3), EIF2B3(4), EIF2B4(4), EIF2B5(4), EIF2S1(2), EIF2S2(6), EIF2S3(1), ELAVL1(5), FLT1(17), FLT4(13), HIF1A(3), KDR(13), NOS3(4), PIK3R1(10), PLCG1(8), PRKCA(7), PTK2(8), PXN(2), SHC1(3)	23822343	128	104	128	31	26	30	33	19	20	0	0.0541	1.000	1.000
326	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	46	APAF1(12), BAD(1), BAX(1), BCL2(1), BCL2A1(2), BCL2L1(2), BCL2L2(1), CASP1(2), CASP10(2), CASP2(3), CASP3(2), CASP4(2), CASP6(5), CASP7(3), CASP9(1), CD40(7), CD40LG(5), CRADD(1), DAXX(5), FADD(4), FAS(5), FASLG(1), IKBKE(5), LTA(4), MCL1(3), NFKB1(5), NFKBIA(1), NGFR(1), NR3C1(6), NTRK1(3), PTPN13(13), RIPK1(2), TFG(1), TNFRSF1A(1), TNFRSF1B(2), TRADD(1), TRAF2(2), TRAF3(6), TRAF6(3)	32204174	127	103	127	35	20	34	30	21	22	0	0.115	1.000	1.000
327	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	20	ATM(16), ATR(25), BRCA1(12), BRCA2(16), CHEK1(1), CHEK2(5), FANCA(7), FANCC(3), FANCD2(9), FANCF(2), FANCG(2), HUS1(2), MRE11A(3), RAD17(7), RAD50(9), RAD51(1), RAD9A(2), TREX1(4)	32865448	126	102	126	27	8	39	31	27	21	0	0.0577	1.000	1.000
328	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(4), F11(2), F12(2), F13B(13), F2(3), F5(20), F7(3), F8(8), F9(9), FGA(10), FGB(4), FGG(6), LPA(16), PLAT(3), PLG(13), SERPINB2(2), SERPINE1(8), VWF(19)	26846529	145	102	144	40	14	39	44	26	22	0	0.137	1.000	1.000
329	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(4), POLA2(2), POLB(1), POLD1(11), POLD2(1), POLD3(4), POLE(11), POLE2(1), POLG(8), POLG2(2), POLH(3), POLI(4), POLK(9), POLL(6), POLM(2), POLQ(22), PRIM1(3), PRIM2(1), REV1(3), REV3L(25), RFC5(2)	30787268	125	102	124	32	20	28	31	20	26	0	0.131	1.000	1.000
330	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(2), AKR1B10(4), ALDOA(1), ALDOB(5), ALDOC(4), FBP2(1), FPGT(5), FUK(3), GMDS(5), GMPPA(1), HK1(4), HK2(5), HK3(8), HSD3B7(2), KHK(3), LHPP(1), MPI(5), MTMR1(1), MTMR2(5), MTMR6(4), PFKFB1(3), PFKFB2(5), PFKFB3(2), PFKFB4(1), PFKL(6), PFKM(6), PFKP(6), PGM2(3), PHPT1(1), PMM2(2), RDH11(2), RDH12(4), SORD(2), TPI1(4), TSTA3(2)	28192307	118	101	118	35	24	26	32	22	14	0	0.0928	1.000	1.000
331	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(27), AXIN1(11), BTRC(1), CCND1(4), CREBBP(39), CSNK1A1(1), CSNK1D(1), CSNK2A1(7), CTBP1(2), CTNNB1(6), DVL1(7), FZD1(6), GSK3B(3), HDAC1(1), MAP3K7(8), MYC(6), NLK(1), PPARD(1), TLE1(8), WIF1(1), WNT1(2)	22357252	143	100	138	36	18	34	36	24	29	2	0.0564	1.000	1.000
332	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	20	ATM(16), ATR(25), BRCA1(12), CCNB1(3), CDC25A(2), CDC25B(4), CDC25C(4), CDC34(4), CHEK1(1), CHEK2(5), GADD45A(1), MDM2(2), MYT1(12), PRKDC(28), RPS6KA1(10), WEE1(1), YWHAH(2), YWHAQ(3)	27511188	135	99	135	28	17	30	39	28	21	0	0.0540	1.000	1.000
333	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ACY3(3), ALDH1A3(1), ALDH1B1(4), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH3B1(3), ALDH3B2(4), ALDH7A1(2), ALDH9A1(3), AMDHD1(3), AOC2(5), AOC3(5), ASPA(4), CARM1(5), CNDP1(9), DDC(7), FTCD(2), HAL(6), HARS(1), HARS2(3), HDC(4), HEMK1(1), HNMT(1), LCMT1(2), LCMT2(7), MAOA(1), MAOB(1), METTL2B(4), METTL6(3), PRMT2(1), PRMT3(6), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(4), PRPS1(3), PRPS2(2), UROC1(4)	30069281	126	99	126	37	22	34	39	17	14	0	0.0628	1.000	1.000
334	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(4), AADAC(5), ABAT(6), ACADS(2), ACAT2(2), ACSM1(6), AKR1B10(4), ALDH1A3(1), ALDH1B1(4), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH5A1(1), ALDH7A1(2), ALDH9A1(3), BDH1(1), BDH2(1), DDHD1(5), ECHS1(2), EHHADH(5), GAD1(4), GAD2(7), HADH(4), HADHA(3), HMGCL(1), HMGCS1(3), HMGCS2(2), HSD17B10(1), HSD17B4(5), HSD3B7(2), ILVBL(6), L2HGDH(4), OXCT1(2), OXCT2(1), PDHA1(4), PDHA2(14), PDHB(1), PLA1A(8), PRDX6(1), RDH11(2), RDH12(4)	30830480	137	99	137	55	17	38	42	25	15	0	0.754	1.000	1.000
335	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1A(5), ADRA1B(3), ADRA1D(3), ADRA2C(3), ADRB1(3), ADRB3(2), CHRM2(5), CHRM3(9), CHRM4(2), CHRM5(3), DRD1(2), DRD2(4), DRD3(6), DRD4(1), DRD5(8), HRH1(1), HRH2(3), HTR1A(9), HTR1B(7), HTR1D(2), HTR1E(8), HTR1F(4), HTR2A(5), HTR2B(2), HTR2C(3), HTR4(2), HTR5A(8), HTR6(6), HTR7(7)	19574300	126	99	126	61	34	17	39	21	15	0	0.747	1.000	1.000
336	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	30	ACVR1(5), APC(27), ATF2(1), AXIN1(11), BMP10(2), BMP2(5), BMP4(4), BMP5(6), BMP7(3), BMPR2(6), CHRD(12), CTNNB1(6), DVL1(7), FZD1(6), GSK3B(3), MAP3K7(8), NKX2-5(1), NOG(2), NPPA(3), NPPB(2), RFC1(3), TGFB1(1), TGFB2(3), TGFB3(1), TGFBR1(2), TGFBR3(5), WNT1(2)	26210907	137	98	135	36	20	30	34	29	23	1	0.110	1.000	1.000
337	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(2), B4GALT1(1), B4GALT2(5), FBP2(1), G6PC(2), GAA(3), GALK1(1), GALK2(2), GALT(2), GANAB(3), GCK(4), GLA(3), GLB1(5), HK1(4), HK2(5), HK3(8), LALBA(1), LCT(17), MGAM(32), PFKM(6), PFKP(6), PGM1(5), PGM3(1)	24702425	119	98	118	28	20	28	33	16	21	1	0.0153	1.000	1.000
338	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(6), ACAA2(1), ACADM(3), ACADS(2), ACAT2(2), ALDH1A3(1), ALDH1B1(4), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH6A1(2), ALDH7A1(2), ALDH9A1(3), AOX1(10), AUH(1), BCAT1(4), BCAT2(4), BCKDHA(3), BCKDHB(4), DBT(7), DLD(1), ECHS1(2), EHHADH(5), HADH(4), HADHA(3), HADHB(4), HIBADH(1), HIBCH(2), HMGCL(1), HMGCS1(3), HMGCS2(2), HSD17B10(1), HSD17B4(5), IVD(5), MCCC1(2), MCCC2(4), MUT(5), OXCT1(2), OXCT2(1), PCCA(9), PCCB(1)	32713574	126	98	125	44	16	33	32	27	18	0	0.608	1.000	1.000
339	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	22	ACTA1(4), CAPN1(3), CAPN2(6), CAPNS1(2), CAPNS2(2), CXCR3(1), EGF(9), EGFR(19), ITGA1(4), ITGB1(16), MYLK(8), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PTK2(8), PXN(2), TLN1(24)	24025925	124	98	122	44	24	20	39	23	17	1	0.610	1.000	1.000
340	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	30	A1BG(7), AKT1(2), AKT2(3), AKT3(6), BAD(1), BTK(8), GSK3A(2), GSK3B(3), IARS(11), IGFBP1(3), INPP5D(9), PDK1(3), PPP1R13B(2), RPS6KA1(10), RPS6KA2(6), RPS6KA3(4), RPS6KB1(5), SFN(7), SHC1(3), SOS1(9), SOS2(11), TEC(2), YWHAB(2), YWHAE(2), YWHAG(1), YWHAH(2), YWHAQ(3), YWHAZ(2)	24676050	129	98	129	45	16	30	39	26	17	1	0.631	1.000	1.000
341	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	14	AKT1(2), BCL2(1), EGFR(19), IGF1R(13), MYC(6), POLR2A(11), PRKCA(7), RB1(18), TEP1(16), TERF1(5), TERT(3), TNKS(7), XRCC5(4)	20871413	112	98	110	40	13	29	29	17	23	1	0.384	1.000	1.000
342	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	AGT(4), ATF2(1), CALM1(1), CALM2(2), CALM3(2), EGFR(19), ELK1(2), JUN(1), MAP2K1(5), MAP2K2(6), MAP2K4(2), MAP3K1(6), MAPK8(4), MEF2A(3), MEF2B(5), MEF2D(1), PAK1(3), PRKCA(7), PTK2(8), PTK2B(4), RAF1(3), SHC1(3), SOS1(9), SYT1(8)	23034129	109	97	109	35	18	17	40	23	11	0	0.470	1.000	1.000
343	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(2), CDC7(1), CDT1(1), DIAPH2(10), GMNN(3), MCM10(6), MCM2(4), MCM3(4), MCM4(7), MCM5(2), MCM6(4), MCM7(9), NACA(25), PCNA(1), POLA2(2), POLD1(11), POLD2(1), POLD3(4), POLE(11), POLE2(1), PRIM1(3), RFC1(3), RFC2(3), RFC3(2), RFC4(4), RFC5(2), RPA1(5), RPA2(1), RPA4(1), RPS27A(1), UBA52(3), UBB(1), UBC(5)	38518834	143	97	142	50	15	38	48	18	23	1	0.774	1.000	1.000
344	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(8), ADRBK2(5), ARRB2(1), CALM1(1), CALM2(2), CALM3(2), CALML3(1), CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), CLCA1(5), CLCA2(6), CLCA4(6), CNGA3(10), CNGA4(5), CNGB1(13), GNAL(4), GUCA1C(1), PDC(2), PDE1C(14), PRKACA(4), PRKACB(3), PRKACG(3), PRKG1(8), PRKG2(2), PRKX(1)	23203428	118	97	118	46	18	26	35	23	16	0	0.630	1.000	1.000
345	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(3), ACTG2(5), ADCY3(8), ADCY9(9), AK1(1), ARF4(1), ARF6(2), ARL4D(1), ATP6V0A1(4), ATP6V0A2(3), ATP6V0A4(6), ATP6V0B(1), ATP6V0C(1), ATP6V0D1(2), ATP6V0D2(3), ATP6V1A(2), ATP6V1C1(4), ATP6V1C2(3), ATP6V1D(2), ATP6V1E1(2), ATP6V1E2(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(3), ATP6V1H(3), ERO1L(3), GNAS(12), PDIA4(1), PLCG1(8), PLCG2(9), PRKCA(7), SEC61A1(4), SEC61A2(4), SEC61B(1), TRIM23(6)	28098922	127	97	127	36	24	28	36	21	18	0	0.0799	1.000	1.000
346	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	ATM(16), BMPR1B(4), CCND2(2), CDK4(5), CDKN1B(2), CEBPB(1), DAZL(3), DMC1(2), EGR1(4), ESR2(1), FSHR(12), GJA4(1), INHA(2), LHCGR(9), MLH1(5), MSH5(3), NCOR1(21), NRIP1(9), PGR(5), PRLR(8), PTGER2(5), VDR(2), ZP2(6)	26643751	128	96	124	37	14	32	39	22	21	0	0.232	1.000	1.000
347	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	20	CDK5(3), CDK5R1(1), CFL1(2), CHN1(7), LIMK1(5), MAP3K1(6), MYLK(8), NCF2(6), PAK1(3), PDGFRA(14), PIK3R1(10), PLD1(15), PPP1R12B(4), RALBP1(5), RPS6KB1(5), TRIO(22), VAV1(8), WASF1(3)	24567635	127	96	127	54	20	29	43	13	22	0	0.949	1.000	1.000
348	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	25	AKT1(2), APC(27), AXIN1(11), CCND1(4), CD14(1), CTNNB1(6), DVL1(7), FZD1(6), GJA1(2), GNAI1(2), GSK3B(3), IRAK1(3), LBP(8), LEF1(5), LY96(2), NFKB1(5), PDPK1(4), PIK3R1(10), RELA(2), TIRAP(1), TLR4(16), TOLLIP(2), WNT1(2)	21801708	131	93	129	39	18	34	32	19	27	1	0.164	1.000	1.000
349	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(6), ACACA(15), ACACB(20), ACADM(3), ACAT2(2), ACSS1(5), ACSS2(2), ALDH1A3(1), ALDH1B1(4), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH6A1(2), ALDH7A1(2), ALDH9A1(3), ECHS1(2), EHHADH(5), HADHA(3), HIBCH(2), LDHA(1), LDHAL6A(2), LDHAL6B(6), LDHB(1), LDHC(4), MLYCD(3), MUT(5), PCCA(9), PCCB(1), SUCLA2(1), SUCLG1(1), SUCLG2(4)	30167579	119	93	119	45	23	22	34	23	17	0	0.777	1.000	1.000
350	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	25	AKT1(2), AKT2(3), AKT3(6), CISH(1), IARS(11), IL13RA1(2), IL4(1), IL4R(8), INPP5D(9), JAK1(11), JAK2(5), JAK3(6), NR0B2(1), PI3(2), PPP1R13B(2), RPS6KB1(5), SERPINA4(7), SHC1(3), SOS1(9), SOS2(11), STAT6(5), TYK2(8)	26383894	118	93	118	45	18	24	38	24	14	0	0.705	1.000	1.000
351	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(21), CD3D(1), CD4(1), CREBBP(39), CSK(1), GNAS(12), GNB1(3), HLA-DRA(1), HLA-DRB1(2), LCK(5), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PTPRC(19), ZAP70(2)	17491281	123	92	120	39	23	25	31	20	23	1	0.269	1.000	1.000
352	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(21), CD3D(1), CD4(1), CREBBP(39), CSK(1), GNAS(12), GNB1(3), HLA-DRA(1), HLA-DRB1(2), LCK(5), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PTPRC(19), ZAP70(2)	17491281	123	92	120	39	23	25	31	20	23	1	0.269	1.000	1.000
353	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	19	ARHGAP5(10), DIAPH1(7), FYN(5), GSN(5), ITGA1(4), ITGB1(16), MAP2K1(5), MYLK(8), PFN1(1), PIK3R1(10), PTK2(8), PXN(2), RAF1(3), ROCK1(19), SHC1(3), TLN1(24)	25884604	130	92	129	37	21	21	35	28	25	0	0.349	1.000	1.000
354	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(7), CALCR(4), CALCRL(5), CD97(5), CRHR1(3), CRHR2(4), ELTD1(11), EMR1(7), EMR2(2), GHRHR(4), GIPR(2), GLP1R(2), GLP2R(3), GPR64(6), LPHN1(11), LPHN2(11), LPHN3(24), SCTR(2), VIPR1(1), VIPR2(6)	20246798	120	92	120	43	15	15	36	38	16	0	0.584	1.000	1.000
355	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	28	AKT1(2), AVP(1), CABIN1(15), CALM1(1), CALM2(2), CALM3(2), CAMK1(2), CAMK1G(2), HDAC5(3), IGF1(1), IGF1R(13), INSR(3), MAP2K6(1), MAPK14(2), MAPK7(6), MEF2A(3), MEF2B(5), MEF2D(1), MYOD1(2), NFATC1(9), NFATC2(15), PIK3R1(10), PPP3CA(2), PPP3CB(1), SYT1(8), YWHAH(2)	24165674	114	92	114	42	20	23	28	28	15	0	0.415	1.000	1.000
356	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM1(1), CALM2(2), CALM3(2), DLG4(3), GRIN1(4), GRIN2A(21), GRIN2B(23), GRIN2C(7), GRIN2D(6), NOS1(9), PPP3CA(2), PPP3CB(1), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PRKCA(7), SYT1(8)	19451476	112	92	112	41	22	27	30	20	13	0	0.255	1.000	1.000
357	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	13	APC(27), AXIN1(11), CREBBP(39), CTNNB1(6), DVL1(7), FZD1(6), GSK3B(3), HDAC1(1), LDB1(2), LEF1(5), PITX2(2), TRRAP(22), WNT1(2)	21511275	133	92	131	31	23	29	31	26	22	2	0.0119	1.000	1.000
358	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	31	AKT1(2), BAD(1), BCL2(1), BCL2L1(2), CBL(3), CFLAR(2), CRKL(3), FOS(6), IL2RA(2), IL2RB(3), IRS1(4), JAK1(11), JAK3(6), MYC(6), NMI(6), PIK3R1(10), PTPN6(2), RAF1(3), RPS6KB1(5), SHC1(3), SOCS1(1), SOCS3(1), SOS1(9), STAT5A(3), STAT5B(5), SYK(8)	24980870	108	91	106	29	14	31	28	16	19	0	0.0402	1.000	1.000
359	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	34	AKT1(2), ATF1(3), CDC42(3), CREB1(1), CREB5(8), DUSP1(2), DUSP10(3), EEF2K(6), EIF4E(1), ELK1(2), GADD45A(1), IL1R1(4), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAP3K10(6), MAP3K4(14), MAP3K5(6), MAP3K7(8), MAPK11(3), MAPK12(3), MAPK13(3), MAPK14(2), MAPKAPK5(2), MKNK1(1), MKNK2(2), MYEF2(7), NFKB1(5), NR2C2(1), SRF(1), TRAF6(3)	24848235	110	91	108	34	16	24	32	22	16	0	0.333	1.000	1.000
360	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CD14(1), CHUK(6), ELK1(2), FOS(6), IKBKB(12), IRAK1(3), JUN(1), LY96(2), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAP3K1(6), MAP3K7(8), MAPK14(2), MAPK8(4), NFKB1(5), NFKBIA(1), PPARA(2), RELA(2), TIRAP(1), TLR10(4), TLR2(3), TLR3(2), TLR4(16), TLR6(4), TLR7(8), TLR9(3), TOLLIP(2), TRAF6(3)	27776437	116	91	115	47	18	25	38	14	21	0	0.819	1.000	1.000
361	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(1), ACP2(2), ACP5(2), ACPP(2), ACPT(2), ALPI(3), ALPL(4), ALPP(3), ALPPL2(7), CYP19A1(3), CYP1A1(2), CYP1A2(5), CYP2A13(4), CYP2A6(2), CYP2A7(4), CYP2B6(5), CYP2C18(3), CYP2C19(6), CYP2C8(6), CYP2C9(7), CYP2D6(5), CYP2E1(6), CYP2F1(2), CYP2J2(7), CYP3A4(6), CYP3A5(1), CYP3A7(1), CYP4B1(3), CYP51A1(1), PON1(7)	22321126	112	90	112	44	15	18	42	21	15	1	0.782	1.000	1.000
362	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	AGXT(2), AGXT2(5), ALAS2(5), AMT(2), AOC2(5), AOC3(5), ATP6V0C(1), BHMT(1), CHDH(3), CHKB(1), CPT1B(4), CTH(3), DAO(2), DLD(1), DMGDH(6), GAMT(2), GARS(1), GATM(4), GCAT(5), GLDC(11), MAOA(1), MAOB(1), PLCB2(7), PLCG1(8), PLCG2(9), PSPH(2), SARDH(9), SARS(1), SHMT1(1), SHMT2(2), TARS(6)	31847778	116	90	116	47	28	20	39	19	10	0	0.702	1.000	1.000
363	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(9), ATP4B(2), ATP5O(1), ATP6AP1(2), ATP6V0A1(4), ATP6V0A4(6), ATP6V0B(1), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(3), ATP6V1C1(4), ATP6V1C2(3), ATP6V1D(2), ATP6V1E1(2), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(3), ATP6V1H(3), ATP7A(12), ATP7B(8), COX10(3), COX5A(2), COX5B(1), COX8A(1), NDUFA1(1), NDUFA5(3), NDUFB2(2), NDUFB4(1), NDUFB6(1), NDUFS1(1), NDUFS2(3), NDUFV1(3), SDHA(7), SDHB(1), SHMT1(1), UQCRC1(1), UQCRFS1(4)	28976279	111	90	109	30	16	28	33	24	10	0	0.0962	1.000	1.000
364	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	21	ATF2(1), BCR(2), BLNK(5), ELK1(2), FOS(6), JUN(1), LYN(8), MAP2K1(5), MAP3K1(6), MAPK8IP3(8), PAPPA(13), RPS6KA1(10), RPS6KA3(4), SHC1(3), SOS1(9), SYK(8), VAV1(8), VAV2(4), VAV3(4)	23230646	107	90	107	27	25	14	30	15	23	0	0.123	1.000	1.000
365	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	19	CCR3(6), CFL1(2), GNAS(12), GNB1(3), LIMK1(5), MAP2K1(5), NOX1(6), PIK3C2G(13), PLCB1(21), PPP1R12B(4), PRKCA(7), PTK2(8), RAF1(3), ROCK2(10)	18294635	105	89	103	33	18	20	39	12	16	0	0.557	1.000	1.000
366	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(15), ACAT2(2), ACYP1(1), ADH5(3), AKR1B1(2), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), DLAT(4), DLD(1), GLO1(2), GRHPR(1), HAGH(1), LDHA(1), LDHB(1), LDHC(4), LDHD(1), MDH1(1), MDH2(1), ME1(2), ME2(3), ME3(7), PC(14), PCK1(1), PDHA1(4), PDHA2(14), PDHB(1), PKLR(3)	28074114	113	89	113	40	21	23	32	22	15	0	0.637	1.000	1.000
367	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	25	AKT1(2), AKT2(3), AKT3(6), BAD(1), BCL2(1), GSK3A(2), GSK3B(3), IL4R(8), IRS1(4), IRS2(6), JAK1(11), JAK3(6), MAP4K1(4), PDK1(3), PIK3CD(8), PIK3R1(10), PPP1R13B(2), RAF1(3), SHC1(3), SOCS1(1), SOS1(9), SOS2(11), STAT6(5)	25670668	112	89	112	34	19	24	30	24	15	0	0.206	1.000	1.000
368	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	AGMAT(1), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), AMD1(4), AOC2(5), AOC3(5), ARG1(1), ARG2(1), ASL(2), CKB(4), CKM(3), CKMT1B(2), CPS1(13), DAO(2), GAMT(2), GATM(4), GLUD1(4), GOT1(1), GOT2(3), MAOA(1), MAOB(1), NOS1(9), NOS3(4), OAT(1), ODC1(3), OTC(2), P4HA1(3), P4HA2(3), P4HA3(1), P4HB(1), PYCR1(1), RARS(1), SMS(3)	33577243	114	88	114	40	22	25	30	21	16	0	0.467	1.000	1.000
369	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	15	C3(16), C5(11), C7(12), ICAM1(6), IL1A(1), IL6(2), ITGA4(13), ITGAL(7), ITGB1(16), ITGB2(4), SELP(15), SELPLG(1), VCAM1(10)	17391670	114	88	113	34	12	32	34	17	19	0	0.133	1.000	1.000
370	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	36	ATF2(1), CDC42(3), CREB1(1), DAXX(5), ELK1(2), HSPB2(2), MAP2K4(2), MAP2K6(1), MAP3K1(6), MAP3K5(6), MAP3K7(8), MAP3K9(9), MAPK14(2), MAPKAPK5(2), MAX(1), MEF2A(3), MEF2B(5), MEF2D(1), MKNK1(1), MYC(6), PLA2G4A(3), RIPK1(2), RPS6KA5(5), SHC1(3), STAT1(7), TGFB1(1), TGFB2(3), TGFB3(1), TGFBR1(2), TRADD(1), TRAF2(2)	26494513	97	88	94	37	17	22	28	14	16	0	0.765	1.000	1.000
371	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA2(1), ACADL(4), ACADM(3), ACADS(2), ACADSB(3), ACAT2(2), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH6A1(2), ALDH9A1(3), AOX1(10), BCAT1(4), BCKDHA(3), BCKDHB(4), ECHS1(2), EHHADH(5), HADHA(3), HADHB(4), HIBADH(1), HMGCL(1), IVD(5), MCCC1(2), MCCC2(4), MUT(5), OXCT1(2), PCCA(9), PCCB(1), SDS(1)	27373833	106	88	105	35	11	22	30	25	18	0	0.640	1.000	1.000
372	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(6), ACADL(4), ACADM(3), ACADSB(3), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), AOC2(5), AOC3(5), CNDP1(9), DPYD(16), DPYS(7), ECHS1(2), EHHADH(5), GAD1(4), GAD2(7), HADHA(3), MLYCD(3), SDS(1), SMS(3), UPB1(2)	22098133	111	87	111	32	12	30	36	22	11	0	0.198	1.000	1.000
373	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	22	ADCY1(21), AKT1(2), CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), CREB1(1), GNAS(12), MAPK14(2), PIK3R1(10), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PRKCA(7), RPS6KA1(10), RPS6KA5(5), SOS1(9)	19336048	106	87	105	26	22	24	29	14	17	0	0.0620	1.000	1.000
374	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	19	ADCY1(21), AKT1(2), ASAH1(1), GNAI1(2), GNB1(3), ITGAV(6), ITGB3(6), PDGFRA(14), PIK3R1(10), PLCB1(21), PRKCA(7), PTK2(8)	18363045	101	87	99	32	13	21	34	16	17	0	0.309	1.000	1.000
375	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(6), ALDH5A1(1), CAD(5), CPS1(13), EARS2(4), EPRS(4), GAD1(4), GAD2(7), GCLC(4), GCLM(1), GFPT1(3), GFPT2(5), GLS(1), GLS2(2), GLUD1(4), GLUD2(10), GLUL(3), GMPS(7), GNPNAT1(1), GOT1(1), GOT2(3), GPT(1), GPT2(3), GSS(3), NADSYN1(2), PPAT(3), QARS(5)	30042916	106	87	106	51	18	24	26	20	18	0	0.954	1.000	1.000
376	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	15	ACTA1(4), ACTN1(4), ACTN2(11), CAPN1(3), CAPNS1(2), CAPNS2(2), ITGA1(4), ITGB1(16), ITGB3(6), PTK2(8), PXN(2), SPTAN1(24), TLN1(24)	21398474	110	87	109	25	18	17	41	19	15	0	0.0441	1.000	1.000
377	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(3), CS(2), DLAT(4), DLD(1), DLST(6), FH(3), IDH2(1), IDH3A(1), IDH3B(1), IDH3G(1), MDH1(1), MDH2(1), OGDH(10), PC(14), PDHA1(4), PDHA2(14), PDHB(1), PDHX(4), PDK1(3), PDK2(1), PDK3(3), PDK4(8), SDHA(7), SDHB(1), SDHC(1), SUCLA2(1), SUCLG1(1), SUCLG2(4)	21552481	102	86	101	29	12	24	35	17	14	0	0.202	1.000	1.000
378	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(3), AASDH(5), AASDHPPT(3), AASS(3), ACAT2(2), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), ATP6V0C(1), BBOX1(1), DLST(6), DOT1L(9), ECHS1(2), EHHADH(5), EHMT1(7), EHMT2(11), GCDH(2), HADHA(3), PLOD1(3), PLOD2(7), PLOD3(4), SDS(1), SHMT1(1), SHMT2(2), TMLHE(2)	28166869	106	85	106	47	19	18	25	23	21	0	0.887	1.000	1.000
379	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(6), ACACA(15), ACADL(4), ACADM(3), ACADSB(3), ACAT2(2), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH6A1(2), ALDH9A1(3), ECHS1(2), EHHADH(5), HADHA(3), LDHA(1), LDHB(1), LDHC(4), MLYCD(3), MUT(5), PCCA(9), PCCB(1), SDS(1), SUCLA2(1), SUCLG1(1), SUCLG2(4)	25172960	99	85	99	32	17	17	31	19	15	0	0.585	1.000	1.000
380	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	ERCC3(5), GTF2A2(1), GTF2B(1), GTF2E1(7), GTF2F2(3), GTF2H1(3), GTF2H4(3), ILK(4), MNAT1(1), POLR1A(10), POLR1B(4), POLR2A(11), POLR2B(10), POLR2C(1), POLR2E(1), POLR2F(3), POLR2G(4), POLR2H(1), POLR2I(1), POLR2J(2), POLR3B(4), POLR3D(3), POLR3E(5), POLR3H(1), TAF13(1), TAF5(7), TAF6(5), TAF7(2), TAF9(3), TBP(2)	26651829	109	85	109	39	8	25	27	22	27	0	0.681	1.000	1.000
381	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	30	DUSP1(2), MAP2K4(2), MAP2K7(2), MAPK10(4), MAPK11(3), MAPK12(3), MAPK13(3), MAPK14(2), MAPK8(4), MAPK8IP1(3), MAPK8IP2(3), MAPK8IP3(8), MAPK9(4), MAPKAPK5(2), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(1), NFKBIE(1), NFKBIL1(1), PIK3CD(8), PIK3R1(10), SYT1(8), TRAF2(2), TRAF3(6), TRAF5(1), TRAF6(3)	23475983	97	85	97	28	20	17	26	11	23	0	0.124	1.000	1.000
382	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ADH1A(2), ADH1B(2), ADH4(3), ADH6(1), ADH7(2), ADHFE1(4), ALDH1A3(1), ALDH3A1(1), ALDH3B1(3), ALDH3B2(4), AOC2(5), AOC3(5), AOX1(10), COMT(1), DBH(8), DCT(4), DDC(7), FAH(2), GOT1(1), GOT2(3), GSTZ1(1), HGD(4), HPD(3), MAOA(1), MAOB(1), PNMT(1), TAT(1), TH(3), TPO(11), TYR(8)	24089511	103	85	102	39	17	25	31	11	19	0	0.494	1.000	1.000
383	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(2), GUSB(5), RPE(1), UGDH(4), UGP2(2), UGT1A1(4), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A9(1), UGT2A1(6), UGT2A3(7), UGT2B10(11), UGT2B11(9), UGT2B15(4), UGT2B17(5), UGT2B28(6), UGT2B4(13), UGT2B7(7), XYLB(3)	20775690	103	84	103	41	14	15	39	25	10	0	0.911	1.000	1.000
384	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	AGXT(2), AGXT2(5), AKR1B10(4), ALAS2(5), AMT(2), AOC2(5), AOC3(5), BHMT(1), CHDH(3), CHKB(1), CTH(3), DAO(2), DLD(1), DMGDH(6), GAMT(2), GARS(1), GATM(4), GCAT(5), GLDC(11), HSD3B7(2), MAOA(1), MAOB(1), PHGDH(1), PIPOX(2), PSAT1(1), PSPH(2), RDH11(2), RDH12(4), SARDH(9), SARS(1), SDS(1), SHMT1(1), SHMT2(2), TARS(6), TARS2(4)	32368566	108	84	108	44	27	20	38	15	7	1	0.682	1.000	1.000
385	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	ARSB(2), FUCA1(1), FUCA2(1), GALNS(1), GBA(3), GLB1(5), GNS(3), GUSB(5), HEXA(4), HGSNAT(3), HPSE(4), HPSE2(4), HYAL1(2), HYAL2(2), IDS(7), IDUA(6), LCT(17), MAN2B1(4), MAN2B2(3), MAN2C1(4), MANBA(4), NAGLU(4), NEU1(2), NEU2(2), NEU3(1), NEU4(2), SPAM1(3)	26180325	99	84	99	44	23	20	20	17	19	0	0.801	1.000	1.000
386	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	20	CHUK(6), CREBBP(39), DUSP1(2), IKBKB(12), IL1B(1), MAP2K3(4), MAP2K6(1), MAP3K7(8), MAPK11(3), MAPK14(2), NFKB1(5), NFKBIA(1), NR3C1(6), RELA(2), TGFBR1(2), TLR2(3)	17962099	97	84	95	27	14	16	29	16	21	1	0.277	1.000	1.000
387	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	28	ATF1(3), BAD(1), BRAF(10), CREB1(1), CREB5(8), DUSP4(1), DUSP6(5), DUSP9(1), EEF2K(6), EIF4E(1), MAP2K1(5), MAP2K2(6), MAP3K8(4), MKNK1(1), MKNK2(2), MOS(7), NFKB1(5), RPS6KA1(10), RPS6KA2(6), RPS6KA3(4), SHC1(3), SOS1(9), SOS2(11), TRAF3(6)	21917671	116	84	115	29	26	22	35	20	13	0	0.0669	1.000	1.000
388	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM1(1), CALM2(2), CALM3(2), CHUK(6), EGR2(5), MAP3K1(6), MYC(6), NFATC1(9), NFATC2(15), NFKB1(5), NFKBIA(1), PLCG1(8), PPP3CA(2), PPP3CB(1), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), RELA(2), SYT1(8), VIP(1), VIPR2(6)	21280054	102	83	100	37	23	20	31	16	12	0	0.444	1.000	1.000
389	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), DAG1(5), ITPKB(5), ITPR1(16), ITPR2(25), ITPR3(10), NFAT5(13), PDE6A(3), PDE6B(2), PDE6C(3), SLC6A13(4), TF(5)	27079943	102	81	102	40	10	36	27	16	13	0	0.533	1.000	1.000
390	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(16), APOA4(4), APOC1(1), CETP(2), CYP7A1(6), DGAT1(1), HMGCR(4), LCAT(2), LDLR(5), LIPC(5), LPL(4), LRP1(34), SCARB1(1), SOAT1(5)	20853162	90	81	89	27	12	21	26	18	13	0	0.252	1.000	1.000
391	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(6), ACADM(3), ALDH1A3(1), ALDH1B1(4), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), ALDH9A1(3), AOC2(5), AOC3(5), CNDP1(9), DPYD(16), DPYS(7), ECHS1(2), EHHADH(5), GAD1(4), GAD2(7), HADHA(3), HIBCH(2), MLYCD(3), SMS(3), UPB1(2)	20536304	96	80	96	30	11	30	29	19	7	0	0.258	1.000	1.000
392	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(4), ALG10(7), ALG10B(3), ALG11(3), ALG12(5), ALG13(4), ALG2(2), ALG3(1), ALG5(2), ALG6(4), ALG8(1), B4GALT1(1), B4GALT2(5), B4GALT3(1), DDOST(1), DHDDS(3), DOLPP1(2), DPAGT1(1), DPM1(2), FUT8(2), GANAB(3), MAN1A1(2), MAN1A2(1), MAN1B1(4), MAN1C1(3), MAN2A1(4), MGAT1(4), MGAT2(2), MGAT3(5), MGAT4A(1), MGAT4B(3), MGAT5(4), MGAT5B(5), RFT1(1), RPN1(2), RPN2(6), ST6GAL1(3), STT3B(2)	32231042	109	80	109	42	14	22	36	17	20	0	0.775	1.000	1.000
393	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B3GNT6(2), B4GALT5(3), C1GALT1(4), C1GALT1C1(3), GALNT1(2), GALNT10(5), GALNT11(4), GALNT12(4), GALNT13(10), GALNT14(6), GALNT2(7), GALNT3(6), GALNT4(3), GALNT5(5), GALNT6(4), GALNT7(3), GALNT8(6), GALNTL5(5), GCNT1(1), GCNT3(1), GCNT4(3), OGT(4), ST3GAL1(2), ST3GAL2(1), ST6GALNAC1(4), WBSCR17(9)	24558538	107	80	107	37	17	28	30	15	16	1	0.537	1.000	1.000
394	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	15	ADAM12(6), AGT(4), AGTR2(2), EDN1(1), EDNRA(2), EDNRB(7), EGF(9), EGFR(19), FOS(6), JUN(1), MYC(6), NFKB1(5), PLCG1(8), PRKCA(7), RELA(2)	15307125	85	79	83	26	12	21	31	13	7	1	0.252	1.000	1.000
395	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	22	GH1(4), GHR(8), INSR(3), IRS1(4), JAK2(5), MAP2K1(5), PIK3R1(10), PLCG1(8), PRKCA(7), PTPN6(2), RAF1(3), RPS6KA1(10), SHC1(3), SLC2A4(3), SOCS1(1), SOS1(9), SRF(1), STAT5A(3), STAT5B(5)	22651414	94	79	94	22	15	25	32	11	11	0	0.0252	1.000	1.000
396	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	39	APAF1(12), BAK1(1), BAX(1), BCL2(1), BCL2L1(2), BID(3), BIRC2(2), BIRC3(2), CASP2(3), CASP3(2), CASP6(5), CASP7(3), CASP9(1), FADD(4), FAS(5), FASLG(1), GZMB(2), JUN(1), MAP2K4(2), MAP3K1(6), MAPK10(4), MCL1(3), MDM2(2), MYC(6), NFKB1(5), NFKBIA(1), PARP1(5), PRF1(4), RELA(2), RIPK1(2), TNFRSF1A(1), TNFRSF1B(2), TNFSF10(1), TRADD(1), TRAF2(2)	27021042	100	78	98	27	18	25	26	14	17	0	0.114	1.000	1.000
397	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	19	AKT1(2), APAF1(12), ATM(16), BAD(1), BAX(1), BCL2(1), BCL2L1(2), BID(3), CASP3(2), CASP6(5), CASP7(3), CASP9(1), EIF2S1(2), PRKCA(7), PTK2(8), PXN(2), STAT1(7), TLN1(24)	20207506	99	78	99	28	12	27	24	19	17	0	0.260	1.000	1.000
398	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	31	APAF1(12), BCL2(1), BID(3), BIRC2(2), BIRC3(2), CASP10(2), CASP3(2), CASP6(5), CASP7(3), CASP9(1), CFLAR(2), CHUK(6), FADD(4), GAS2(3), LMNA(1), NFKB1(5), NFKBIA(1), RELA(2), RIPK1(2), SPTAN1(24), TNFRSF10A(3), TNFRSF10B(1), TNFRSF25(2), TNFSF10(1), TRADD(1), TRAF2(2)	24567054	93	78	93	24	18	23	22	11	19	0	0.0653	1.000	1.000
399	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	ALOX12(3), ALOX5(5), CBR3(1), CYP4F2(7), CYP4F3(3), EPX(10), GGT1(4), LTA4H(1), MPO(8), PLA2G1B(2), PLA2G2A(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PRDX2(2), PRDX6(1), PTGDS(2), PTGES2(1), PTGIS(7), PTGS1(7), PTGS2(4), TBXAS1(5), TPO(11)	21251910	95	78	94	47	22	17	27	10	19	0	0.898	1.000	1.000
400	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	21	ADCY1(21), AKT1(2), BAD(1), BAX(1), BCL2(1), BCL2L1(2), CSF2RB(8), IGF1(1), IGF1R(13), IL3(1), IL3RA(6), KIT(11), KITLG(1), PIK3R1(10), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), YWHAH(2)	15019889	97	77	96	30	15	24	24	17	17	0	0.162	1.000	1.000
401	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	37	ANAPC1(8), ANAPC2(1), ANAPC4(2), ANAPC5(1), ANAPC7(1), BTRC(1), CDC16(2), CDC20(2), CDC23(4), CDC26(1), CDC27(8), CUL1(11), CUL2(3), FBXW11(3), FZR1(4), ITCH(7), RBX1(3), SKP1(1), SKP2(4), SMURF1(3), SMURF2(6), TCEB1(2), UBA1(1), UBE2D2(1), UBE2D3(1), UBE2D4(1), UBE2E1(1), WWP1(7), WWP2(5)	28013249	95	77	95	35	9	29	21	21	15	0	0.733	1.000	1.000
402	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(6), IKBKB(12), IL1A(1), IL1B(1), IL1R1(4), IL1RAP(6), IL6(2), IRAK1(3), IRAK2(2), IRAK3(9), JUN(1), MAP2K3(4), MAP2K6(1), MAP3K1(6), MAP3K7(8), MAPK14(2), MAPK8(4), NFKB1(5), NFKBIA(1), RELA(2), TGFB1(1), TGFB2(3), TGFB3(1), TOLLIP(2), TRAF6(3)	22629746	90	77	89	32	18	17	25	12	18	0	0.640	1.000	1.000
403	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(4), ACO1(7), ACO2(3), CLYBL(1), CS(2), DLD(1), DLST(6), FH(3), IDH1(4), IDH2(1), IDH3A(1), IDH3B(1), IDH3G(1), MDH1(1), MDH2(1), OGDH(10), OGDHL(12), PC(14), PCK1(1), PCK2(4), SDHA(7), SDHB(1), SDHC(1), SUCLA2(1), SUCLG1(1), SUCLG2(4)	22686178	93	76	92	36	18	18	29	15	13	0	0.618	1.000	1.000
404	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSA(1), ARSD(4), ARSE(2), ASAH1(1), B4GALT6(2), CERK(3), DEGS1(1), DEGS2(1), ENPP7(5), GAL3ST1(3), GALC(2), GBA(3), GLA(3), GLB1(5), LCT(17), NEU1(2), NEU2(2), NEU3(1), NEU4(2), PPAP2A(1), PPAP2B(1), SGMS1(2), SGMS2(1), SGPP1(5), SGPP2(2), SMPD3(2), SMPD4(5), SPHK2(3), SPTLC1(5), SPTLC2(3), UGCG(1)	27239418	91	76	91	43	19	22	25	12	13	0	0.764	1.000	1.000
405	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(3), ABAT(6), ADSL(5), ADSS(4), AGXT(2), AGXT2(5), ASL(2), ASNS(5), ASPA(4), CAD(5), CRAT(6), DARS(5), DDO(1), GAD1(4), GAD2(7), GOT1(1), GOT2(3), GPT(1), GPT2(3), NARS(2), PC(14)	19803813	88	75	88	28	15	17	30	14	12	0	0.322	1.000	1.000
406	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOA(1), ALDOB(5), ALDOC(4), FBP2(1), G6PD(4), GPI(3), H6PD(2), PFKL(6), PFKM(6), PFKP(6), PGD(2), PGM1(5), PGM3(1), PRPS1(3), PRPS1L1(5), PRPS2(2), RBKS(3), RPE(1), RPIA(3), TALDO1(5), TKT(3), TKTL1(6), TKTL2(8)	18450820	85	75	85	31	14	16	25	19	11	0	0.491	1.000	1.000
407	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ARG1(1), ARG2(1), ASL(2), ASS1(2), CKB(4), CKM(3), CKMT1B(2), CPS1(13), DAO(2), EPRS(4), GAMT(2), GATM(4), GLUD1(4), GLUD2(10), GOT1(1), GOT2(3), LAP3(2), NOS1(9), NOS3(4), OAT(1), OTC(2), P4HA1(3), P4HA2(3), P4HA3(1), PARS2(5), PRODH(1), PYCR1(1), RARS(1), RARS2(3)	27312081	94	75	94	33	20	17	22	22	13	0	0.544	1.000	1.000
408	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	15	CBL(3), EGF(9), EGFR(19), MAP2K1(5), PTPRB(22), RAF1(3), SHC1(3), SOS1(9), SPRY1(3), SPRY2(2), SPRY3(3), SPRY4(2)	16585991	83	75	83	26	13	13	28	18	10	1	0.482	1.000	1.000
409	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(6), ALDH5A1(1), CAD(5), CPS1(13), EPRS(4), GAD1(4), GAD2(7), GCLC(4), GCLM(1), GFPT1(3), GLS(1), GLS2(2), GLUD1(4), GLUL(3), GMPS(7), GOT1(1), GOT2(3), GPT(1), GPT2(3), GSS(3), NADSYN1(2), PPAT(3), QARS(5)	25243521	86	74	86	41	13	21	21	17	14	0	0.941	1.000	1.000
410	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	21	AKT1(2), AP2A1(3), AP2M1(3), BAD(1), BTK(8), EEA1(11), GRASP(1), GSK3A(2), GSK3B(3), LYN(8), PDPK1(4), PFKL(6), PFKM(6), PFKP(6), PLCG1(8), PRKCE(3), PRKCZ(3), RAB5A(3), RPS6KB1(5), VAV2(4)	18709470	90	74	89	29	12	17	29	13	18	1	0.411	1.000	1.000
411	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(5), GTF2A1(3), GTF2B(1), GTF2E1(7), GTF2F1(4), HDAC3(3), NCOA1(7), NCOA2(8), NCOA3(8), NCOR2(24), POLR2A(11), RARA(4), RXRA(5), TBP(2)	18982669	92	74	92	26	12	21	25	23	11	0	0.158	1.000	1.000
412	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	21	BTK(8), DLG4(3), EPHB2(3), F2(3), F2RL1(1), F2RL2(2), F2RL3(3), JUN(1), MAP2K5(3), MAPK7(6), MAPK8(4), MYEF2(7), PLD1(15), PLD2(1), PLD3(2), PTK2(8), RAF1(3), RASAL1(5), TEC(2), VAV1(8)	20396850	88	73	88	26	6	19	26	16	20	1	0.296	1.000	1.000
413	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(3), AKR1D1(3), ARSB(2), ARSD(4), ARSE(2), CYP11B1(6), CYP11B2(4), HSD11B2(3), HSD17B2(2), HSD17B3(2), HSD17B8(3), HSD3B1(4), HSD3B2(4), STS(3), SULT1E1(5), SULT2A1(2), UGT1A1(4), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A9(1), UGT2B15(4), UGT2B4(13)	20760596	87	72	87	35	18	14	27	19	9	0	0.767	1.000	1.000
414	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA2(1), ACAD8(4), ACAD9(2), ADH1A(2), ADH1B(2), ADH4(3), ADH5(3), ADH6(1), ADH7(2), ADHFE1(4), AKR1B10(4), AKR1C4(3), AKR1D1(3), ALDH1A3(1), ALDH1B1(4), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), ALDH9A1(3), BAAT(2), CEL(2), CYP27A1(3), CYP7A1(6), HADHB(4), HSD3B7(2), LIPA(3), RDH11(2), RDH12(4), SLC27A5(4), SOAT1(5), SOAT2(2)	24044556	87	72	87	38	17	20	26	16	8	0	0.839	1.000	1.000
415	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	11	CREBBP(39), DAXX(5), PAX3(6), PML(1), RARA(4), RB1(18), SIRT1(2), SP100(8), TNFRSF1A(1), TNFRSF1B(2)	13524169	86	72	85	26	8	17	24	10	26	1	0.392	1.000	1.000
416	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(4), ABAT(6), ACADS(2), ACAT2(2), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH5A1(1), ALDH9A1(3), ECHS1(2), EHHADH(5), GAD1(4), GAD2(7), HADHA(3), HMGCL(1), L2HGDH(4), OXCT1(2), PDHA1(4), PDHA2(14), PDHB(1), SDHB(1), SDS(1)	19612415	87	71	87	33	10	26	25	12	14	0	0.676	1.000	1.000
417	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	17	CSF1(2), CSF1R(2), DDX20(4), E2F4(2), ETS1(4), ETS2(7), FOS(6), HDAC2(3), HDAC5(3), JUN(1), NCOR2(24), RBL1(11), RBL2(6), SIN3A(6), SIN3B(11)	19454627	92	71	92	29	16	27	23	14	12	0	0.157	1.000	1.000
418	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(2), ALDOA(1), ALDOB(5), ALDOC(4), FBP2(1), FPGT(5), GCK(4), GMDS(5), GMPPA(1), HK1(4), HK2(5), HK3(8), KHK(3), MPI(5), PFKFB1(3), PFKFB3(2), PFKFB4(1), PFKM(6), PFKP(6), PMM2(2), SORD(2), TPI1(4)	18131556	79	71	79	22	14	22	18	14	11	0	0.0594	1.000	1.000
419	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	CHUK(6), FADD(4), IKBKB(12), IL1A(1), IL1R1(4), IRAK1(3), MAP3K1(6), MAP3K7(8), NFKB1(5), NFKBIA(1), RELA(2), RIPK1(2), TLR4(16), TNFAIP3(6), TNFRSF1A(1), TNFRSF1B(2), TRADD(1), TRAF6(3)	18588574	83	71	82	29	15	17	26	13	12	0	0.506	1.000	1.000
420	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	25	BCAR1(3), CALM1(1), CALM2(2), CALM3(2), CRKL(3), JUN(1), MAP2K1(5), MAP2K2(6), MAP2K3(4), MAP2K4(2), MAP3K1(6), MAPK14(2), MAPK8(4), PAK1(3), PLCG1(8), PRKCA(7), PTK2B(4), RAF1(3), SHC1(3), SOS1(9), SYT1(8)	20509374	86	71	86	30	21	12	31	12	10	0	0.599	1.000	1.000
421	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	11	ACE2(3), AGT(4), AGTR2(2), CMA1(5), COL4A1(10), COL4A2(9), COL4A3(19), COL4A4(14), COL4A5(14), COL4A6(4), REN(3)	18588701	87	70	86	39	10	26	27	13	11	0	0.968	1.000	1.000
422	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	20	BCAR1(3), CRK(2), CXCL12(3), CXCR4(2), GNAI1(2), GNB1(3), MAP2K1(5), NFKB1(5), PIK3C2G(13), PIK3R1(10), PLCG1(8), PRKCA(7), PTK2(8), PTK2B(4), PXN(2), RAF1(3), RELA(2)	18542196	82	70	81	30	14	12	24	14	18	0	0.800	1.000	1.000
423	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	19	AKT1(2), EIF4A1(3), EIF4A2(2), EIF4E(1), EIF4EBP1(1), EIF4G1(19), EIF4G2(9), EIF4G3(9), GHR(8), IRS1(4), MAPK14(2), MKNK1(1), PABPC1(1), PDK2(1), PDPK1(4), PIK3R1(10), PRKCA(7), RPS6KB1(5)	18642654	89	70	88	26	3	25	23	14	24	0	0.449	1.000	1.000
424	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(4), ALOX5(5), CYP1A2(5), CYP2C18(3), CYP2C19(6), CYP2C8(6), CYP2C9(7), CYP2E1(6), CYP2J2(7), CYP3A4(6), CYP3A43(2), CYP3A5(1), CYP3A7(1), HSD3B7(2), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), RDH11(2), RDH12(4)	18172097	84	70	84	31	11	15	36	12	9	1	0.584	1.000	1.000
425	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(2), ASNS(5), ASRGL1(1), CA1(1), CA12(2), CA14(3), CA2(1), CA3(5), CA4(5), CA5A(1), CA5B(1), CA6(3), CA7(1), CA8(5), CA9(1), CPS1(13), CTH(3), GLS(1), GLS2(2), GLUD1(4), GLUD2(10), GLUL(3), HAL(6)	16146378	79	70	79	33	16	17	21	16	9	0	0.834	1.000	1.000
426	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	16	ACE(8), ACE2(3), AGT(4), AGTR2(2), CMA1(5), CPA3(7), CTSA(1), CTSG(1), ENPEP(14), LNPEP(5), MAS1(2), MME(16), NLN(10), REN(3), THOP1(1)	15535590	82	70	82	32	11	13	31	15	12	0	0.711	1.000	1.000
427	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	14	ATN1(14), BAIAP2(2), CASP1(2), CASP3(2), CASP7(3), GAPDH(2), INSR(3), ITCH(7), MAGI1(14), MAGI2(20), RERE(7), WWP1(7), WWP2(5)	17353403	88	70	88	36	13	26	21	16	12	0	0.843	1.000	1.000
428	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(17), AP2A1(3), AP2M1(3), BIN1(4), CALM1(1), CALM2(2), CALM3(2), DNM1(2), EPN1(5), EPS15(7), NME2(1), PICALM(4), PPP3CA(2), PPP3CB(1), SYNJ1(9), SYNJ2(9), SYT1(8)	16499519	80	70	80	34	10	15	27	15	13	0	0.909	1.000	1.000
429	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(3), CHIA(6), CHIT1(4), CTBS(3), CYB5R1(1), CYB5R3(6), GFPT1(3), GFPT2(5), GNE(2), GNPDA1(2), GNPNAT1(1), HEXA(4), HK1(4), HK2(5), HK3(8), LHPP(1), MTMR1(1), MTMR2(5), MTMR6(4), NANS(2), PGM3(1), PHPT1(1), RENBP(5), UAP1(4)	21800018	81	69	81	27	20	16	21	8	16	0	0.357	1.000	1.000
430	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	19	AKT1(2), EIF4A1(3), EIF4A2(2), EIF4B(7), EIF4E(1), EIF4EBP1(1), EIF4G1(19), EIF4G2(9), EIF4G3(9), MKNK1(1), PDK2(1), PDPK1(4), PIK3R1(10), RPS6KB1(5), TSC1(4), TSC2(8)	18753629	86	69	85	22	6	22	23	10	25	0	0.275	1.000	1.000
431	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(10), ARHGEF1(9), GNA12(1), GNA13(2), GNB1(3), MYLK(8), PLCB1(21), PPP1R12B(4), PRKCA(7), ROCK1(19)	15718096	84	69	83	30	14	16	28	15	11	0	0.695	1.000	1.000
432	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(10), COL4A2(9), COL4A3(19), COL4A4(14), COL4A5(14), COL4A6(4), P4HB(1), SLC23A1(3), SLC23A2(7), SLC2A1(4), SLC2A3(2)	18991315	87	69	86	40	10	27	23	15	12	0	0.959	1.000	1.000
433	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	20	AKT1(2), BCL2(1), BCR(2), CRKL(3), FOS(6), JAK2(5), JUN(1), MAP2K1(5), MAP2K4(2), MAP3K1(6), MAPK8(4), MYC(6), PIK3R1(10), RAF1(3), SOS1(9), STAT1(7), STAT5A(3), STAT5B(5)	19413464	80	68	78	25	9	24	25	8	14	0	0.293	1.000	1.000
434	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(3), CARS(4), DARS(5), EPRS(4), FARS2(4), GARS(1), HARS(1), IARS(11), KARS(3), LARS(5), LARS2(2), MARS(2), MARS2(5), NARS(2), QARS(5), RARS(1), SARS(1), TARS(6), WARS(2), WARS2(8), YARS(7)	24299185	82	67	82	21	6	14	33	20	9	0	0.266	1.000	1.000
435	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(3), CSF1R(2), EGF(9), EGFR(19), MET(4), PDGFRA(14), PRKCA(7), SH3GLB1(2), SH3GLB2(3), SH3KBP1(8)	14746309	71	67	71	21	9	15	23	12	11	1	0.248	1.000	1.000
436	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5(3), CDK5R1(1), CSNK1D(1), DRD1(2), DRD2(4), GRM1(29), PLCB1(21), PPP1CA(1), PPP1R1B(2), PPP3CA(2), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3)	12136445	82	67	80	30	15	21	24	18	4	0	0.364	1.000	1.000
437	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH3B1(3), ALDH3B2(4), ALDH9A1(3), AOC2(5), AOC3(5), ASPA(4), CNDP1(9), DDC(7), HAL(6), HARS(1), HDC(4), HNMT(1), MAOA(1), MAOB(1), PRPS1(3), PRPS2(2)	18542350	79	67	79	25	11	18	28	12	10	0	0.278	1.000	1.000
438	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	18	ABL1(8), ATM(16), BRCA1(12), CHEK1(1), CHEK2(5), GADD45A(1), JUN(1), MAPK8(4), MDM2(2), MRE11A(3), NFKB1(5), NFKBIA(1), RAD50(9), RAD51(1), RBBP8(7), RELA(2)	22063335	78	66	77	24	6	20	24	14	14	0	0.656	1.000	1.000
439	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ACY1(3), AGMAT(1), ALDH18A1(2), ALDH1A3(1), ALDH1B1(4), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), ALDH9A1(3), AMD1(4), AOC2(5), AOC3(5), ARG1(1), ARG2(1), ASL(2), ASS1(2), CPS1(13), GATM(4), MAOA(1), MAOB(1), NAGS(3), ODC1(3), OTC(2), SAT1(4), SAT2(2), SMS(3)	22360443	76	66	76	26	17	21	19	11	8	0	0.349	1.000	1.000
440	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	17	CABIN1(15), CALM1(1), CALM2(2), CALM3(2), CAPN2(6), CAPNS1(2), CAPNS2(2), HDAC1(1), HDAC2(3), MEF2D(1), NFATC1(9), NFATC2(15), PPP3CA(2), PPP3CB(1), PRKCA(7), SYT1(8)	14816740	77	66	76	27	12	17	21	19	8	0	0.392	1.000	1.000
441	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCL3(1), CCR1(1), CCR2(4), CCR3(6), CCR4(4), CCR7(2), CD28(3), CD4(1), CXCR3(1), CXCR4(2), IFNG(2), IFNGR1(4), IFNGR2(5), IL12A(1), IL12B(4), IL12RB1(4), IL12RB2(11), IL18R1(3), IL2(2), IL4(1), IL4R(8), IL5(2), TGFB1(1), TGFB2(3), TGFB3(1)	15203829	77	64	76	26	10	13	24	14	16	0	0.387	1.000	1.000
442	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	17	DNAJA3(3), IFNG(2), IFNGR1(4), IFNGR2(5), IKBKB(12), JAK2(5), LIN7A(5), NFKB1(5), NFKBIA(1), RB1(18), RELA(2), TNFRSF1A(1), TNFRSF1B(2), USH1C(3), WT1(3)	13216630	71	64	70	22	6	12	23	8	22	0	0.409	1.000	1.000
443	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	CALM1(1), CALM2(2), CALM3(2), MARCKS(1), NFATC1(9), NFATC2(15), NFATC3(6), NFATC4(3), PLCG1(8), PPP3CA(2), PPP3CB(1), PRKCA(7), SP1(3), SP3(3), SYT1(8)	15979389	71	62	71	26	14	13	22	15	7	0	0.535	1.000	1.000
444	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(4), ACTN2(11), BCAR1(3), CSK(1), CTNNA1(8), CTNNA2(29), CTNNB1(6), PTK2(8), PXN(2), VCL(6)	14613213	78	62	76	37	10	16	28	12	11	1	0.968	1.000	1.000
445	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(2), GALNS(1), GLB1(5), GNS(3), GUSB(5), HEXA(4), HGSNAT(3), HPSE(4), HPSE2(4), HYAL1(2), HYAL2(2), IDS(7), IDUA(6), LCT(17), NAGLU(4), SPAM1(3)	15532358	72	62	72	31	13	15	14	16	14	0	0.802	1.000	1.000
446	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(4), B4GALNT1(3), GLB1(5), HEXA(4), LCT(17), SLC33A1(2), ST3GAL1(2), ST3GAL2(1), ST3GAL5(6), ST6GALNAC3(8), ST6GALNAC5(5), ST6GALNAC6(4), ST8SIA1(3), ST8SIA5(7)	12508670	71	62	71	23	15	14	20	11	11	0	0.269	1.000	1.000
447	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(3), ICAM1(6), ITGA4(13), ITGAL(7), ITGAM(8), ITGB1(16), ITGB2(4), SELE(7), SELL(2), SELP(15)	12108439	81	62	80	29	9	18	21	12	21	0	0.540	1.000	1.000
448	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(2), ASNS(5), CA1(1), CA12(2), CA14(3), CA2(1), CA3(5), CA4(5), CA5A(1), CA5B(1), CA6(3), CA7(1), CA8(5), CA9(1), CPS1(13), CTH(3), GLS(1), GLS2(2), GLUD1(4), GLUL(3), HAL(6)	14444489	68	62	68	28	12	16	18	15	7	0	0.804	1.000	1.000
449	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(1), ALDOB(5), ALDOC(4), FBP2(1), G6PD(4), GPI(3), H6PD(2), PFKM(6), PFKP(6), PGD(2), PGM1(5), PGM3(1), PRPS1(3), PRPS1L1(5), PRPS2(2), RBKS(3), RPE(1), RPIA(3), TAL1(3), TALDO1(5), TKT(3)	15543179	68	62	68	25	11	13	19	16	9	0	0.458	1.000	1.000
450	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ALDH1A3(1), ALDH3A1(1), ALDH3B1(3), ALDH3B2(4), AOC2(5), AOC3(5), DDC(7), EPX(10), ESCO1(4), ESCO2(4), GOT1(1), GOT2(3), HPD(3), MAOA(1), MAOB(1), MPO(8), PRDX6(1), SH3GLB1(2), TAT(1), TPO(11)	26016506	76	61	75	37	15	16	27	6	12	0	0.924	1.000	1.000
451	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(2), BLVRA(3), CP(8), CPOX(1), EPRS(4), FECH(1), GUSB(5), HCCS(2), HMOX1(1), HMOX2(1), PPOX(1), UGT1A1(4), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A9(1), UGT2B15(4), UGT2B4(13), UROD(1), UROS(4)	20864118	69	61	69	36	8	11	25	17	8	0	0.993	1.000	1.000
452	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	ATF1(3), CASP2(3), CHUK(6), CRADD(1), IKBKB(12), JUN(1), LTA(4), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAP3K1(6), MAP4K2(2), MAPK14(2), MAPK8(4), NFKB1(5), NFKBIA(1), RELA(2), RIPK1(2), TANK(2), TNFRSF1A(1), TRADD(1), TRAF2(2)	18415390	67	61	67	25	13	12	21	9	12	0	0.665	1.000	1.000
453	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(9), IL13(1), IL4(1), IL5(2), JUNB(2), MAF(1), MAP2K3(4), MAPK14(2), NFATC1(9), NFATC2(15), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3)	9250727	62	60	62	26	18	13	13	9	9	0	0.414	1.000	1.000
454	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	14	AKT1(2), CREB1(1), MAP2K1(5), MAP2K2(6), MAP2K3(4), MAP2K6(1), MAP3K1(6), MAPK14(2), NFKB1(5), PIK3R1(10), RB1(18), RELA(2), SP1(3)	12579283	65	60	65	22	10	7	17	5	26	0	0.821	1.000	1.000
455	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	18	AKT1(2), CCND1(4), CCNE1(5), CDK4(5), CDK6(2), CDKN1B(2), NFKB1(5), NFKBIA(1), PAK1(3), PIK3R1(10), RAF1(3), RB1(18), RELA(2), TFDP1(2)	12559647	64	60	64	18	4	12	12	8	28	0	0.321	1.000	1.000
456	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP1(1), ACP2(2), ACP5(2), ACP6(5), ACPP(2), ACPT(2), ALPI(3), ALPL(4), ALPP(3), ALPPL2(7), CMBL(2), CYP3A4(6), CYP3A43(2), CYP3A5(1), CYP3A7(1), DHRS1(2), DHRS2(4), DHRS3(1), DHRS7(1), PON1(7), PON2(1), PON3(9)	13706360	68	59	67	28	10	9	23	12	14	0	0.849	1.000	1.000
457	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(1), CARM1(5), CTH(3), GGT1(4), HEMK1(1), LCMT1(2), LCMT2(7), MARS(2), MARS2(5), MAT1A(1), METTL2B(4), METTL6(3), PAPSS1(6), PAPSS2(6), PRMT2(1), PRMT3(6), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(4), SCLY(1), SEPHS1(1), SEPHS2(3)	18938494	74	59	74	23	17	20	19	11	7	0	0.179	1.000	1.000
458	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(3), EXT2(5), EXTL1(3), EXTL2(3), EXTL3(2), GLCE(1), HS2ST1(5), HS3ST2(2), HS3ST3A1(3), HS3ST3B1(1), HS3ST5(6), HS6ST1(3), HS6ST2(1), HS6ST3(1), NDST1(1), NDST2(2), NDST3(7), NDST4(15)	15808855	64	59	64	31	14	11	23	9	7	0	0.929	1.000	1.000
459	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(6), DUSP1(2), IKBKAP(6), IKBKB(12), LTA(4), MAP3K1(6), NFKB1(5), NFKBIA(1), RELA(2), RIPK1(2), TANK(2), TNFAIP3(6), TNFRSF1B(2), TRAF2(2), TRAF3(6)	17108010	64	59	64	22	12	14	17	7	14	0	0.448	1.000	1.000
460	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(10), BST1(2), CD38(5), ENPP1(10), ENPP3(8), NADK(2), NADSYN1(2), NMNAT1(4), NMNAT2(1), NNMT(3), NNT(6), NT5C1A(2), NT5C1B(7), NT5C2(2), NT5E(1), NUDT12(4), QPRT(1)	16385816	70	58	70	36	9	9	23	18	11	0	0.984	1.000	1.000
461	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ALDH1A3(1), ALDH3A1(1), ALDH3B1(3), ALDH3B2(4), AOC2(5), AOC3(5), DDC(7), EPX(10), GOT1(1), GOT2(3), HPD(3), MAOA(1), MAOB(1), MPO(8), PRDX2(2), PRDX6(1), TAT(1), TPO(11)	16695952	68	58	67	32	15	15	23	6	9	0	0.769	1.000	1.000
462	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	AANAT(1), ACHE(2), CHAT(9), COMT(1), DBH(8), DDC(7), GAD1(4), GAD2(7), HDC(4), MAOA(1), PAH(7), PNMT(1), SLC18A3(6), TH(3), TPH1(2)	10979411	63	57	63	28	9	13	23	5	13	0	0.766	1.000	1.000
463	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(21), CFTR(14), GNAS(12), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), SLC9A3R1(1)	9965823	64	57	63	20	18	13	18	9	6	0	0.322	1.000	1.000
464	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(21), GNAS(12), GNB1(3), PRKAA1(4), PRKAA2(4), PRKAB1(4), PRKAB2(2), PRKACB(3), PRKACG(3), PRKAG2(2), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3)	11662340	68	57	67	23	20	10	20	10	8	0	0.578	1.000	1.000
465	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(1), POLD1(11), POLD2(1), POLE(11), POLG(8), POLL(6), POLQ(22)	12728592	60	57	60	17	11	12	14	7	16	0	0.229	1.000	1.000
466	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOA(1), ALDOB(5), ALDOC(4), FBP2(1), GOT1(1), GOT2(3), GPT(1), GPT2(3), MDH1(1), MDH2(1), ME1(2), ME3(7), PGK1(2), PGK2(5), PKLR(3), RPE(1), RPIA(3), TKT(3), TKTL1(6), TKTL2(8), TPI1(4)	15364646	65	57	65	23	10	14	23	11	7	0	0.519	1.000	1.000
467	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	18	ABCB1(20), AKT1(2), ATM(16), BAX(1), CPB2(4), CSNK1A1(1), CSNK1D(1), FHL2(1), GADD45A(1), HIC1(1), HIF1A(3), IGFBP3(1), MAPK8(4), MDM2(2), NFKBIB(1), NQO1(3)	15197591	62	57	62	24	9	12	18	10	13	0	0.854	1.000	1.000
468	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(21), GNAS(12), PLCE1(21), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), RAP2B(2)	11244945	72	57	71	23	20	14	21	8	9	0	0.328	1.000	1.000
469	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(4), BCAT2(4), COASY(2), DPYD(16), DPYS(7), ENPP1(10), ENPP3(8), ILVBL(6), PANK1(2), PANK2(2), PANK3(2), PANK4(1), PPCS(2), UPB1(2), VNN1(3)	13169729	71	56	71	29	8	15	23	16	9	0	0.823	1.000	1.000
470	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(30), MAP2(20), PPP1CA(1), PRKACB(3), PRKACG(3), PRKAR2B(3), PRKCE(3)	13782702	63	55	62	20	4	7	24	11	17	0	0.836	1.000	1.000
471	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(5), CR1(10), CR2(8), FCGR2B(1), HLA-DRA(1), HLA-DRB1(2), ICAM1(6), ITGAL(7), ITGB2(4), PTPRC(19)	11557965	63	55	62	29	4	17	17	9	16	0	0.919	1.000	1.000
472	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(2), AGPAT2(3), AGPAT3(3), AGPAT4(2), AGPAT6(2), AGPS(5), CHPT1(2), ENPP2(10), ENPP6(5), PAFAH1B1(1), PAFAH1B3(1), PAFAH2(1), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PLD1(15), PLD2(1), PPAP2A(1), PPAP2B(1)	17648206	72	55	72	23	5	20	23	12	12	0	0.350	1.000	1.000
473	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSA(1), ARSB(2), ARSD(4), ARSE(2), ASAH1(1), GAL3ST1(3), GALC(2), GBA(3), GLA(3), GLB1(5), LCT(17), NEU1(2), NEU2(2), NEU3(1), NEU4(2), PPAP2A(1), PPAP2B(1), SPTLC1(5), SPTLC2(3), UGCG(1)	18358974	61	54	61	32	13	16	16	6	10	0	0.894	1.000	1.000
474	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	36	G6PD(4), GCLC(4), GCLM(1), GGT1(4), GPX2(1), GPX5(2), GPX6(4), GPX7(1), GSS(3), GSTA1(3), GSTA2(1), GSTA3(2), GSTA5(2), GSTK1(2), GSTM1(1), GSTM2(3), GSTM3(1), GSTM4(5), GSTM5(1), GSTP1(1), GSTT1(1), GSTZ1(1), IDH1(4), IDH2(1), MGST1(1), MGST2(1), MGST3(2), OPLAH(6)	16828021	63	54	63	29	11	17	17	12	6	0	0.662	1.000	1.000
475	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(5), IL22(2), IL22RA1(4), IL22RA2(1), JAK1(11), JAK2(5), JAK3(6), SOCS3(1), STAT1(7), STAT3(6), STAT5A(3), STAT5B(5), TYK2(8)	13969727	64	54	64	26	8	19	18	10	9	0	0.527	1.000	1.000
476	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(15), CPT1A(6), LEP(1), LEPR(20), PRKAA1(4), PRKAA2(4), PRKAB1(4), PRKAB2(2), PRKAG2(2)	10992549	58	54	58	30	9	8	21	8	12	0	0.990	1.000	1.000
477	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(4), F13A1(8), F2(3), F2R(4), FGA(10), FGB(4), FGG(6), PLAT(3), PLG(13), SERPINB2(2), SERPINE1(8)	10177414	65	53	65	22	5	16	18	9	17	0	0.595	1.000	1.000
478	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(1), AMD1(4), BHMT(1), CTH(3), DNMT1(11), DNMT3A(13), DNMT3B(9), MARS(2), MARS2(5), MAT1A(1), MTAP(4), MTFMT(4), MTR(8), TAT(1)	15762418	67	53	67	25	9	14	15	13	16	0	0.489	1.000	1.000
479	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(4), BCAT2(4), IARS(11), IARS2(3), ILVBL(6), LARS(5), LARS2(2), PDHA1(4), PDHA2(14), PDHB(1), VARS(6), VARS2(4)	14172257	64	53	64	23	3	24	20	7	10	0	0.571	1.000	1.000
480	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(10), POLR1B(4), POLR1C(2), POLR2A(11), POLR2B(10), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(3), POLR2G(4), POLR2H(1), POLR2I(1), POLR2J(2), POLR2L(2), POLR3A(9), POLR3B(4), POLR3G(1), POLR3GL(2), POLR3H(1)	17836859	70	53	70	21	6	16	20	13	15	0	0.351	1.000	1.000
481	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(1), CHUK(6), IFNG(2), IKBKB(12), IL2(2), IL4(1), JUN(1), MAP3K1(6), MAP3K5(6), MAP4K5(2), MAPK14(2), MAPK8(4), NFKB1(5), NFKBIA(1), RELA(2), TNFRSF9(4), TNFSF9(1), TRAF2(2)	14780390	60	52	60	20	9	9	21	7	14	0	0.624	1.000	1.000
482	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA2(1), ADH1A(2), ADH1B(2), ADH4(3), ADH6(1), ADH7(2), ADHFE1(4), AKR1C4(3), AKR1D1(3), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), BAAT(2), CEL(2), CYP27A1(3), CYP7A1(6), HADHB(4), SOAT2(2)	17667332	63	52	63	28	10	11	18	14	10	0	0.901	1.000	1.000
483	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(7), ACO2(3), CS(2), DLD(1), DLST(6), FH(3), IDH1(4), IDH2(1), IDH3A(1), IDH3B(1), IDH3G(1), MDH1(1), MDH2(1), PC(14), PCK1(1), SDHA(7), SDHB(1), SUCLA2(1), SUCLG1(1), SUCLG2(4)	15649727	61	52	60	21	10	16	18	10	7	0	0.351	1.000	1.000
484	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(11), EGF(9), EGFR(19), HGS(2), RAB5A(3), TF(5), TFRC(7)	9752921	56	52	56	21	5	12	17	11	10	1	0.810	1.000	1.000
485	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(4), ALDH1A3(1), ALDH1B1(4), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), ALDH9A1(3), CYP2C19(6), CYP2C9(7), DHRS1(2), DHRS2(4), DHRS3(1), DHRS7(1), ECHS1(2), EHHADH(5), ESCO1(4), ESCO2(4), HADHA(3), SH3GLB1(2), YOD1(4)	23523236	63	52	63	28	3	14	20	16	10	0	0.924	1.000	1.000
486	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(5), ABCC2(9), ABCG2(4), BCHE(5), CES1(7), CES2(8), CYP3A4(6), CYP3A5(1), UGT1A1(4), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A9(1)	17365735	63	52	63	35	13	10	24	8	8	0	0.964	1.000	1.000
487	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(3), ALDH18A1(2), ARG1(1), ARG2(1), ASL(2), CKB(4), CKM(3), CKMT1B(2), CPS1(13), GAMT(2), GATM(4), GLUD1(4), NAGS(3), OAT(1), ODC1(3), OTC(2), PYCR1(1), SMS(3)	13320479	54	52	54	16	15	15	13	7	4	0	0.162	1.000	1.000
488	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(6), DUSP1(2), IKBKAP(6), IKBKB(12), MAP3K1(6), NFKB1(5), NFKBIA(1), RELA(2), TNFAIP3(6), TRAF3(6), TRAF6(3)	13818226	55	51	55	18	10	12	15	5	13	0	0.472	1.000	1.000
489	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	B3GNT1(3), B3GNT2(1), B3GNT3(5), B3GNT5(2), B4GALT1(1), B4GALT2(5), B4GALT3(1), B4GALT4(2), FUT2(2), FUT3(3), FUT5(4), FUT6(2), FUT7(1), FUT9(11), GCNT2(5), ST3GAL6(4), ST8SIA1(3)	12353169	55	51	53	16	8	15	23	5	4	0	0.165	1.000	1.000
490	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(9), AMT(2), ATIC(5), DHFR(3), FTCD(2), GART(4), MTFMT(4), MTHFD1(7), MTHFD1L(6), MTHFD2(3), MTHFR(2), MTHFS(2), MTR(8), SHMT1(1), SHMT2(2), TYMS(2)	14376024	62	51	62	25	9	6	25	9	12	1	0.845	1.000	1.000
491	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(1), ACP2(2), ACP5(2), ACP6(5), ACPP(2), ACPT(2), ENPP1(10), ENPP3(8), FLAD1(5), LHPP(1), MTMR1(1), MTMR2(5), MTMR6(4), PHPT1(1), TYR(8)	11427331	57	51	57	18	11	5	24	6	11	0	0.700	1.000	1.000
492	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	BET1(1), BNIP1(1), GOSR1(4), GOSR2(1), SNAP25(3), STX11(6), STX12(1), STX17(4), STX18(4), STX19(3), STX4(7), STX5(4), STX7(3), STX8(2), TSNARE1(5), USE1(1), VAMP1(3), VAMP5(1), VAMP7(1), VTI1A(1), YKT6(1)	12701549	57	51	56	17	11	13	16	4	13	0	0.291	1.000	1.000
493	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CD3D(1), CXCR3(1), ETV5(5), IFNG(2), IL12A(1), IL12B(4), IL12RB1(4), IL12RB2(11), IL18(1), IL18R1(3), JAK2(5), JUN(1), MAP2K6(1), MAPK14(2), MAPK8(4), STAT4(6), TYK2(8)	14191291	60	51	60	23	5	13	18	8	16	0	0.772	1.000	1.000
494	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	26	BAG4(6), BIRC2(2), BIRC3(2), CASP3(2), CFLAR(2), FADD(4), JUN(1), MAP2K4(2), MAP3K3(3), MAP3K7(8), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(1), NFKBIE(1), NFKBIL1(1), NR2C2(1), RALBP1(5), RIPK1(2), TNFAIP3(6), TNFRSF1A(1), TNFRSF1B(2), TRADD(1), TRAF2(2)	19926143	66	51	65	23	15	20	16	7	8	0	0.346	1.000	1.000
495	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	17	AKT1(2), EIF2B5(4), EIF2S1(2), EIF2S2(6), EIF2S3(1), EIF4E(1), EIF4EBP1(1), GSK3B(3), IGF1(1), IGF1R(13), INPPL1(9), PDK2(1), PDPK1(4), PIK3R1(10), RPS6KB1(5)	12712212	63	50	62	18	9	18	13	7	16	0	0.301	1.000	1.000
496	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(3), JAK1(11), PTPRU(9), REG1A(13), STAT1(7), STAT2(5), TYK2(8)	9506297	56	50	56	22	9	14	15	7	11	0	0.593	1.000	1.000
497	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	28	BECN1(2), GABARAPL1(1), IFNA10(1), IFNA14(1), IFNA16(4), IFNA17(3), IFNA2(1), IFNA21(2), IFNA4(4), IFNA6(1), IFNA8(3), IFNG(2), PIK3C3(5), PIK3R4(11), PRKAA1(4), PRKAA2(4), ULK1(8)	14523233	57	49	57	25	8	8	26	11	4	0	0.931	1.000	1.000
498	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(20), ABCB11(9), ABCB4(13), ABCC1(5), ABCC3(4), GSTP1(1)	10885488	52	49	52	24	7	10	18	3	14	0	0.806	1.000	1.000
499	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(2), GALNS(1), GLB1(5), GNS(3), GUSB(5), HEXA(4), IDS(7), IDUA(6), LCT(17), NAGLU(4)	10912235	54	48	54	23	11	14	12	10	7	0	0.644	1.000	1.000
500	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(15), ACACB(20), FASN(10), MCAT(3), OLAH(3), OXSM(3)	12070202	54	48	54	23	13	12	14	10	5	0	0.676	1.000	1.000
501	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(3), ICAM1(6), ITGA4(13), ITGAL(7), ITGB1(16), ITGB2(4), SELE(7), SELL(2)	9205718	58	48	57	23	7	14	13	8	16	0	0.651	1.000	1.000
502	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(9), AMT(2), ATIC(5), ATP6V0C(1), DHFR(3), GART(4), MTHFD1(7), MTHFD1L(6), MTHFD2(3), MTHFR(2), MTHFS(2), MTR(8), SHMT1(1), SHMT2(2), TYMS(2)	13581168	57	48	57	26	9	5	25	8	9	1	0.940	1.000	1.000
503	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(4), COASY(2), DPYD(16), DPYS(7), ENPP1(10), ENPP3(8), PANK1(2), PANK2(2), PANK3(2), PANK4(1), PPCS(2), UPB1(2)	10610737	58	48	58	22	7	10	19	14	8	0	0.775	1.000	1.000
504	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(6), ESR2(1), PDE1A(6), PDE1B(4), PLCB1(21), PLCB2(7), PRL(4), TRH(2), VIP(1)	8460897	52	48	51	23	6	7	24	10	5	0	0.844	1.000	1.000
505	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	13	AKT1(2), AKT2(3), AKT3(6), BPNT1(2), ILK(4), PDK1(3), PIK3CD(8), PTK2B(4), RBL2(6), SHC1(3), SOS1(9)	12749744	50	48	50	17	12	9	14	11	4	0	0.489	1.000	1.000
506	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(2), GABRA1(11), GABRA2(13), GABRA3(7), GABRA4(5), GABRA5(6), GABRA6(6), GPHN(4), NSF(1), UBQLN1(2)	9111054	57	47	56	25	5	10	21	9	12	0	0.943	1.000	1.000
507	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CYB5R3(6), GCK(4), GFPT1(3), GNE(2), GNPDA1(2), HEXA(4), HK1(4), HK2(5), HK3(8), PGM3(1), RENBP(5), UAP1(4)	12878816	48	46	48	16	13	13	9	6	7	0	0.352	1.000	1.000
508	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	CD2(1), CD33(2), CD5(1), CD7(2), IFNG(2), IL12A(1), IL12B(4), IL13(1), IL3(1), IL4(1), IL5(2), ITGAX(7), TLR2(3), TLR4(16), TLR7(8), TLR9(3)	14151845	55	46	55	28	8	12	17	9	9	0	0.897	1.000	1.000
509	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(2), GUSB(5), RPE(1), UCHL3(1), UGDH(4), UGT1A1(4), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A9(1), UGT2B15(4), UGT2B4(13)	13372374	48	46	48	26	9	4	15	15	5	0	0.980	1.000	1.000
510	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	20	APAF1(12), ARHGDIB(1), BIRC2(2), BIRC3(2), CASP1(2), CASP10(2), CASP2(3), CASP3(2), CASP4(2), CASP6(5), CASP7(3), CASP9(1), GZMB(2), LMNA(1), LMNB1(1), LMNB2(8), PRF1(4)	13797785	53	45	53	13	10	13	9	12	9	0	0.172	1.000	1.000
511	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	FUCA1(1), FUCA2(1), GLB1(5), HEXA(4), LCT(17), MAN2B1(4), MAN2B2(3), MAN2C1(4), MANBA(4), NEU1(2), NEU2(2), NEU3(1), NEU4(2)	15482055	50	45	50	25	15	8	12	6	9	0	0.825	1.000	1.000
512	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(7), ACO2(3), AFMID(6), CS(2), GRHPR(1), HAO1(12), HAO2(1), HYI(1), MDH1(1), MDH2(1), MTHFD1(7), MTHFD1L(6), MTHFD2(3)	10171935	51	45	51	16	6	13	17	8	6	1	0.483	1.000	1.000
513	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(4), ACADM(3), ACADS(2), ACADVL(4), ACSL1(3), ACSL3(3), ACSL4(6), CPT1A(6), CPT2(7), EHHADH(5), HADHA(3), SCP2(2), SLC25A20(3)	12775859	51	45	51	20	5	13	11	12	10	0	0.762	1.000	1.000
514	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(2), GALNT10(5), GALNT2(7), GALNT3(6), GALNT4(3), GALNT6(4), GALNT7(3), GALNT8(6), GCNT1(1), ST3GAL1(2), ST3GAL2(1), ST3GAL4(1), WBSCR17(9)	10976813	50	45	50	19	8	14	14	5	8	1	0.591	1.000	1.000
515	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(4), KHK(3), LCT(17), MPI(5), PGM1(5), PYGL(9), PYGM(8), TPI1(4)	10134954	55	44	55	18	10	14	15	8	8	0	0.227	1.000	1.000
516	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(11), GABRA2(13), GABRA3(7), GABRA4(5), GABRA5(6), GABRA6(6), PRKCE(3), SOD1(1)	5981221	52	44	51	19	4	7	21	8	12	0	0.805	1.000	1.000
517	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	30	G6PD(4), GCLC(4), GCLM(1), GGT1(4), GPX2(1), GPX5(2), GSS(3), GSTA1(3), GSTA2(1), GSTA3(2), GSTM1(1), GSTM2(3), GSTM3(1), GSTM4(5), GSTM5(1), GSTP1(1), GSTT1(1), GSTZ1(1), IDH1(4), IDH2(1), MGST1(1), MGST2(1), MGST3(2), PGD(2)	13740469	50	44	50	20	11	13	11	9	6	0	0.489	1.000	1.000
518	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(1), GPLD1(3), PGAP1(4), PIGA(2), PIGB(3), PIGC(2), PIGG(6), PIGK(6), PIGN(3), PIGO(4), PIGP(1), PIGQ(4), PIGS(2), PIGT(2), PIGU(1), PIGV(1), PIGW(2), PIGX(2), PIGZ(2)	18076612	51	44	51	33	8	13	15	6	9	0	0.995	1.000	1.000
519	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	13	AKT1(2), AKT2(3), AKT3(6), ELK1(2), MAP2K1(5), MAP2K2(6), NGFR(1), NTRK1(3), PIK3CD(8), SHC1(3), SOS1(9)	10293649	48	44	48	18	15	6	13	11	3	0	0.615	1.000	1.000
520	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOA(1), ALDOB(5), ALDOC(4), FBP2(1), GOT1(1), GOT2(3), GPT(1), GPT2(3), MDH1(1), MDH2(1), ME1(2), ME2(3), ME3(7), PGK1(2), PKLR(3), RPE(1), RPIA(3), TKT(3), TPI1(4)	13746524	49	43	49	18	9	10	16	9	5	0	0.565	1.000	1.000
521	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(5), AOC2(5), AOC3(5), CES1(7), DDHD1(5), ESCO1(4), ESCO2(4), LIPA(3), PLA1A(8), PRDX6(1), SH3GLB1(2)	19292782	49	43	49	12	4	12	19	8	6	0	0.268	1.000	1.000
522	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(1), BHMT(1), CTH(3), DNMT1(11), DNMT3A(13), DNMT3B(9), MARS(2), MARS2(5), MAT1A(1), MTR(8)	13211457	54	43	54	23	8	12	13	11	10	0	0.679	1.000	1.000
523	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(10), CD38(5), ENPP1(10), ENPP3(8), NADSYN1(2), NMNAT1(4), NMNAT2(1), NNMT(3), NNT(6), NT5E(1), QPRT(1)	11070058	51	43	51	27	4	7	19	13	8	0	0.981	1.000	1.000
524	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	12	AKT1(2), BAD(1), CHRNB1(1), CHRNG(9), MUSK(7), PIK3R1(10), PTK2(8), PTK2B(4), TERT(3), YWHAH(2)	10798624	47	42	47	23	7	9	12	8	11	0	0.873	1.000	1.000
525	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(2), IL4(1), IL4R(8), IRS1(4), JAK1(11), JAK3(6), RPS6KB1(5), SHC1(3), STAT6(5)	11221458	45	42	45	13	7	11	12	8	7	0	0.220	1.000	1.000
526	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(1), ALG5(2), B4GALT1(1), B4GALT2(5), B4GALT3(1), B4GALT5(3), DDOST(1), DPAGT1(1), DPM1(2), FUT8(2), MAN1A1(2), MAN1B1(4), MGAT1(4), MGAT2(2), MGAT3(5), MGAT4A(1), MGAT4B(3), MGAT5(4), RPN1(2), RPN2(6), ST6GAL1(3)	15241478	55	42	55	18	9	9	15	9	13	0	0.448	1.000	1.000
527	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(5), ADSS(4), DHFR(3), HPRT1(2), IMPDH1(3), MTHFD2(3), NME2(1), OAZ1(2), POLB(1), POLD1(11), POLG(8), PRPS2(2), RRM1(1)	9527178	46	42	46	16	12	5	18	2	9	0	0.554	1.000	1.000
528	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(1), CD28(3), CD3D(1), CD8A(2), ICAM1(6), ITGAL(7), ITGB2(4), PTPRC(19), THY1(2)	8175122	45	42	45	22	4	8	10	9	14	0	0.872	1.000	1.000
529	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	19	BAD(1), BAX(1), BCL2(1), FADD(4), MAP2K1(5), MAP2K4(2), MAP3K1(6), MAPK8(4), NFKB1(5), NSMAF(6), RAF1(3), RELA(2), RIPK1(2), TNFRSF1A(1), TRADD(1), TRAF2(2)	14253683	46	41	46	21	11	5	17	6	7	0	0.911	1.000	1.000
530	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(7), ACO2(3), CS(2), GRHPR(1), HAO1(12), HAO2(1), HYI(1), MDH1(1), MDH2(1), MTHFD1(7), MTHFD1L(6), MTHFD2(3)	9711714	45	41	45	16	6	10	16	7	5	1	0.666	1.000	1.000
531	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(1), CD28(3), CD3D(1), CD4(1), ICAM1(6), ITGAL(7), ITGB2(4), PTPRC(19), THY1(2)	8577979	44	41	44	22	3	8	10	10	13	0	0.885	1.000	1.000
532	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARFGAP1(3), ARFGAP3(5), ARFGEF2(14), CLTA(1), CLTB(1), COPA(7), GBF1(12), GPLD1(3)	12328265	46	40	46	14	5	16	12	4	9	0	0.253	1.000	1.000
533	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREB1(1), CREM(1), FOS(6), JUN(1), OPRK1(7), POLR2A(11), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3)	9805793	43	40	43	17	9	12	11	6	5	0	0.541	1.000	1.000
534	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(9), EGFR(19), ERBB3(14), NRG1(1)	7831161	43	40	43	16	5	9	11	12	5	1	0.759	1.000	1.000
535	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(3), B3GNT2(1), B3GNT7(3), B4GALT1(1), B4GALT2(5), B4GALT3(1), B4GALT4(2), CHST1(4), CHST2(5), CHST4(4), CHST6(8), FUT8(2), ST3GAL1(2), ST3GAL2(1), ST3GAL3(4), ST3GAL4(1)	9584644	47	40	47	22	19	8	14	2	4	0	0.756	1.000	1.000
536	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT2(2), ACOT11(4), ACYP1(1), DHRS1(2), DHRS2(4), DHRS3(1), DHRS7(1), ECHS1(2), EHHADH(5), ESCO1(4), ESCO2(4), FN3K(3), GCDH(2), HADHA(3), SH3GLB1(2), YOD1(4)	19773448	44	40	44	16	2	11	12	11	8	0	0.675	1.000	1.000
537	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	ALDOA(1), CTSD(5), ESR1(6), GREB1(18), HSPB2(2), MTA1(8), MTA3(2), PDZK1(1), TUBA8(2)	8345615	45	40	45	21	12	3	16	8	6	0	0.832	1.000	1.000
538	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	17	ACTA1(4), ACTR2(1), ARPC1B(3), ARPC2(2), ARPC3(1), ARPC4(1), NCK1(5), NCKAP1(8), NTRK1(3), PIR(1), WASF1(3), WASF2(5), WASF3(5), WASL(2)	11260187	44	39	44	22	10	10	11	9	4	0	0.958	1.000	1.000
539	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	FUCA1(1), FUCA2(1), GLB1(5), HEXA(4), LCT(17), MAN2C1(4), MANBA(4), NEU1(2), NEU2(2), NEU3(1), NEU4(2)	12562163	43	39	43	21	12	6	12	6	7	0	0.829	1.000	1.000
540	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	12	ACTR2(1), ARPC1B(3), ARPC2(2), ARPC3(1), ARPC4(1), CDC42(3), PAK1(3), PDGFRA(14), PIK3R1(10), WASL(2)	8177237	40	38	40	16	4	8	13	6	9	0	0.917	1.000	1.000
541	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(3), CYP51A1(1), DHCR24(1), DHCR7(1), EBP(1), FDFT1(4), FDPS(2), GGCX(5), GGPS1(1), HMGCR(4), HSD17B7(1), IDI1(1), IDI2(1), LSS(4), MVD(2), NQO1(3), NSDHL(2), PMVK(4), TM7SF2(2)	14668829	43	38	43	18	11	10	9	5	8	0	0.643	1.000	1.000
542	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(3), CAT(4), EPX(10), MPO(8), MTHFR(2), PRDX6(1), SHMT1(1), SHMT2(2), TPO(11)	8827971	42	38	41	22	15	6	15	3	3	0	0.892	1.000	1.000
543	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(4), PSMA2(1), PSMA3(2), PSMA5(1), PSMA6(2), PSMB1(1), PSMB2(1), PSMB3(1), PSMB4(2), PSMB5(3), PSMB6(1), PSMB7(1), PSMC2(6), PSMC3(2), PSMD1(6), PSMD11(1), PSMD12(1), PSMD13(1), PSMD2(6)	12149192	43	38	43	15	3	8	16	11	5	0	0.710	1.000	1.000
544	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(3), ATP6V0C(1), CAT(4), EPX(10), MPO(8), PRDX2(2), PRDX6(1), SHMT1(1), SHMT2(2), TPO(11)	8975989	43	38	42	22	14	6	15	5	3	0	0.890	1.000	1.000
545	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	MRPS7(1), RPL10A(1), RPL10L(6), RPL12(1), RPL13A(2), RPL18A(1), RPL26(1), RPL27(1), RPL28(1), RPL3(5), RPL31(2), RPL32(1), RPL37(2), RPL37A(1), RPL39(1), RPL3L(1), RPL6(3), RPL8(1), RPS10(2), RPS13(2), RPS15A(1), RPS20(1), RPS21(1), RPS23(1), RPS25(2), RPS26(1), RPS28(1), RPS3(1), RPS5(1)	17258755	46	37	46	23	5	10	18	4	9	0	0.921	1.000	1.000
546	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(2), CLOCK(6), CRY1(6), CRY2(3), CSNK1D(1), CSNK1E(6), NPAS2(2), NR1D1(1), PER1(7), PER2(2), PER3(7)	12977866	43	37	43	18	11	10	10	9	3	0	0.681	1.000	1.000
547	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(3), HMOX1(1), IL10RA(5), IL10RB(2), IL1A(1), IL6(2), JAK1(11), STAT1(7), STAT3(6), STAT5A(3)	9254119	41	37	41	19	3	15	11	6	6	0	0.579	1.000	1.000
548	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CD2(1), CD3D(1), CD4(1), CXCR3(1), IFNG(2), IL12A(1), IL12B(4), IL12RB1(4), IL12RB2(11), JAK2(5), STAT4(6), TYK2(8)	11170748	45	37	45	19	4	10	14	7	10	0	0.789	1.000	1.000
549	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP5O(1), ATP6AP1(2), ATP6V0A1(4), ATP6V0A4(6), ATP6V0B(1), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(3), ATP6V1C1(4), ATP6V1C2(3), ATP6V1D(2), ATP6V1E1(2), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(3), ATP6V1H(3), FDXR(3), SHMT1(1)	12146771	48	37	48	16	6	9	17	9	7	0	0.590	1.000	1.000
550	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(1), ACP2(2), ACP5(2), ACPP(2), ACPT(2), ENPP1(10), ENPP3(8), FLAD1(5), TYR(8)	7388664	40	37	40	14	5	5	19	4	7	0	0.741	1.000	1.000
551	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(8), CD44(3), CSF1(2), FCGR3A(7), IL1B(1), IL6R(5), SELL(2), SPN(3), TGFB1(1), TGFB2(3), TNFRSF1A(1), TNFRSF1B(2), TNFRSF8(2), TNFSF8(2)	10031334	42	37	42	19	6	12	10	10	4	0	0.679	1.000	1.000
552	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(6), MAPK14(2), MAPK8(4), NFKB1(5), RELA(2), TNFRSF13B(1), TNFRSF13C(2), TNFSF13(1), TNFSF13B(2), TRAF2(2), TRAF3(6), TRAF5(1), TRAF6(3)	11090459	37	37	36	13	4	9	12	1	11	0	0.598	1.000	1.000
553	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	C9orf47(1), CNR1(4), DNMT1(11), MTNR1A(3), MTNR1B(3), PTGDR(3), PTGER2(5), PTGER4(6), PTGFR(2), PTGIR(2), TBXA2R(1)	8514322	41	36	41	22	8	8	16	5	4	0	0.770	1.000	1.000
554	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(1), ATP6AP1(2), ATP6V0A1(4), ATP6V0A4(6), ATP6V0B(1), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(3), ATP6V1C1(4), ATP6V1C2(3), ATP6V1D(2), ATP6V1E1(2), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(3), ATP6V1H(3), SHMT1(1)	11410965	45	35	45	14	5	9	15	9	7	0	0.486	1.000	1.000
555	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(1), ATP6AP1(2), ATP6V0A1(4), ATP6V0A4(6), ATP6V0B(1), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(3), ATP6V1C1(4), ATP6V1C2(3), ATP6V1D(2), ATP6V1E1(2), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(3), ATP6V1H(3), SHMT1(1)	11410965	45	35	45	14	5	9	15	9	7	0	0.486	1.000	1.000
556	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(4), CARS2(1), CDO1(2), CTH(3), GOT1(1), GOT2(3), LDHA(1), LDHAL6A(2), LDHAL6B(6), LDHB(1), LDHC(4), MPST(2), SDS(1), SULT1B1(3), SULT1C2(3), SULT1C4(2), SULT4A1(1)	9523891	40	35	40	15	8	5	15	7	5	0	0.688	1.000	1.000
557	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(4), ACAD9(2), ADH1A(2), ADH1B(2), ADH4(3), ADH5(3), ADH6(1), ADH7(2), ADHFE1(4), DHRS1(2), DHRS2(4), DHRS3(1), DHRS7(1), ESCO1(4), ESCO2(4), SH3GLB1(2)	18987938	41	35	41	16	3	12	8	8	10	0	0.754	1.000	1.000
558	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(10), MPO(8), PRDX2(2), PRDX6(1), TPO(11), TYR(8)	7343191	40	35	39	18	11	4	17	4	4	0	0.818	1.000	1.000
559	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(1), ATP6AP1(2), ATP6V0A1(4), ATP6V0A4(6), ATP6V0B(1), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(3), ATP6V1C1(4), ATP6V1C2(3), ATP6V1D(2), ATP6V1E1(2), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(3), ATP6V1H(3), SHMT1(1)	11410965	45	35	45	14	5	9	15	9	7	0	0.486	1.000	1.000
560	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(4), IARS(11), LARS(5), LARS2(2), PDHA1(4), PDHA2(14), PDHB(1)	7603533	41	35	41	13	0	16	13	6	6	0	0.622	1.000	1.000
561	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(2), CYSLTR2(5), GPR161(4), GPR171(3), GPR18(1), GPR34(1), GPR39(7), GPR45(5), GPR65(2), GPR68(2), GPR75(5)	7484334	37	34	37	19	11	6	7	7	6	0	0.887	1.000	1.000
562	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	NFKB1(5), NFKBIA(1), PLCB1(21), PRKCA(7), RELA(2)	6273776	36	34	35	12	5	6	15	6	4	0	0.519	1.000	1.000
563	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(1), IL13RA1(2), IL13RA2(4), IL4R(8), JAK1(11), JAK2(5), TYK2(8)	7970737	39	34	39	14	8	8	9	7	7	0	0.578	1.000	1.000
564	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(1), IL13RA1(2), IL13RA2(4), IL4R(8), JAK1(11), JAK2(5), TYK2(8)	7970737	39	34	39	14	8	8	9	7	7	0	0.578	1.000	1.000
565	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(2), CHAT(9), PCYT1A(2), PDHA1(4), PDHA2(14), SLC18A3(6)	5331209	37	33	37	19	4	10	14	4	5	0	0.874	1.000	1.000
566	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(7), EIF2AK4(7), EIF2B5(4), EIF2S1(2), EIF2S2(6), EIF2S3(1), EIF5(3), GSK3B(3), PPP1CA(1)	8797320	34	33	34	14	3	9	10	4	8	0	0.895	1.000	1.000
567	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(8), EPO(2), EPOR(2), GRIN1(4), HIF1A(3), JAK2(5), NFKB1(5), NFKBIA(1), RELA(2), SOD2(1)	9657990	33	33	33	10	4	11	6	7	5	0	0.276	1.000	1.000
568	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	12	ARNT(8), ASPH(10), COPS5(2), CREB1(1), EDN1(1), EPO(2), HIF1A(3), JUN(1), LDHA(1), NOS3(4), P4HB(1)	9165972	34	33	34	13	6	10	7	8	3	0	0.604	1.000	1.000
569	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(3), ICAM1(6), ITGAL(7), ITGAM(8), ITGB2(4), SELE(7), SELL(2)	7886915	37	33	37	21	4	9	7	5	12	0	0.895	1.000	1.000
570	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	AKR1B10(4), DHRS1(2), DHRS2(4), DHRS3(1), DHRS7(1), HSD3B7(2), PON1(7), PON2(1), PON3(9), RDH11(2), RDH12(4)	6840643	37	32	36	17	3	7	11	11	5	0	0.830	1.000	1.000
571	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNAR1(3), IFNAR2(2), JAK1(11), STAT1(7), STAT2(5), TYK2(8)	8257040	36	32	36	16	5	10	7	5	9	0	0.739	1.000	1.000
572	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3D(1), CD4(1), FYN(5), HLA-DRA(1), HLA-DRB1(2), LCK(5), PTPRC(19), ZAP70(2)	6869407	36	32	35	18	3	8	8	7	10	0	0.907	1.000	1.000
573	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CD4(1), CSF1(2), HLA-DRA(1), HLA-DRB1(2), IFNG(2), IL12A(1), IL12B(4), IL13(1), IL1A(1), IL2(2), IL3(1), IL4(1), IL5(2), IL6(2), IL7(1), LTA(4), TGFB1(1), TGFB2(3), TGFB3(1)	10113759	33	31	32	17	5	8	6	8	6	0	0.913	1.000	1.000
574	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), ECHS1(2), EHHADH(5), HADHA(3), SDS(1)	9244748	34	31	34	14	4	5	10	9	6	0	0.825	1.000	1.000
575	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	8	CAMK1(2), CAMK1G(2), HDAC9(16), MEF2A(3), MEF2B(5), MEF2D(1), MYOD1(2), YWHAH(2)	5163667	33	31	33	11	7	5	9	9	3	0	0.516	1.000	1.000
576	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	6	JAK1(11), JAK2(5), JAK3(6), STAT3(6), TYK2(8)	8386337	36	31	36	13	5	6	10	9	6	0	0.572	1.000	1.000
577	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(3), AKR1D1(3), CYP11A1(3), CYP11B1(6), CYP11B2(4), CYP17A1(1), HSD11B2(3), HSD3B1(4), HSD3B2(4)	7004272	31	29	31	15	10	3	8	5	4	1	0.837	1.000	1.000
578	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(3), AKR1D1(3), CYP11A1(3), CYP11B1(6), CYP11B2(4), CYP17A1(1), HSD11B2(3), HSD3B1(4), HSD3B2(4)	7004272	31	29	31	15	10	3	8	5	4	1	0.837	1.000	1.000
579	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(2), ADH1B(2), ADH4(3), ADH5(3), ADH6(1), ADH7(2), ADHFE1(4), ALDH1A3(1), ALDH1B1(4), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), ALDH9A1(3)	10054416	31	29	31	15	4	8	6	7	6	0	0.876	1.000	1.000
580	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(10), GBA(3), MPO(8), PRDX6(1), TPO(11)	6371299	33	29	32	16	11	5	12	2	3	0	0.804	1.000	1.000
581	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(2), CLOCK(6), CRY1(6), CRY2(3), CSNK1E(6), PER1(7)	6487339	30	28	30	11	6	6	8	9	1	0	0.632	1.000	1.000
582	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(4), ACO1(7), ACO2(3), ACSS1(5), ACSS2(2), FH(3), IDH1(4), IDH2(1), MDH1(1), MDH2(1), SUCLA2(1)	10104755	32	28	32	14	3	10	11	2	6	0	0.723	1.000	1.000
583	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(7), CAPN1(3), CAPNS1(2), CAPNS2(2), CDK5(3), CDK5R1(1), CSNK1A1(1), CSNK1D(1), GSK3B(3), MAPT(8)	7011957	31	28	31	10	6	8	10	5	2	0	0.367	1.000	1.000
584	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(1), CTH(3), GGT1(4), MARS(2), MARS2(5), MAT1A(1), PAPSS1(6), PAPSS2(6), SCLY(1), SEPHS1(1)	9404841	30	28	30	12	7	9	7	5	2	0	0.567	1.000	1.000
585	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	7	ACE(8), AGT(4), AGTR2(2), BDKRB2(3), KNG1(4), NOS3(4), REN(3)	6950425	28	27	28	16	5	7	8	3	5	0	0.857	1.000	1.000
586	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(3), CS(2), FH(3), IDH2(1), MDH1(1), OGDH(10), SDHA(7), SUCLA2(1)	7148129	28	27	27	10	4	4	11	5	4	0	0.705	1.000	1.000
587	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	CYP51A1(1), DHCR7(1), FDFT1(4), FDPS(2), HMGCR(4), HMGCS1(3), IDI1(1), LSS(4), MVD(2), NSDHL(2), PMVK(4)	10028443	28	25	28	12	9	8	3	4	4	0	0.564	1.000	1.000
588	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	15	CD28(3), CD3D(1), IFNG(2), IL2(2), IL2RA(2), IL4(1), TGFB1(1), TGFB2(3), TGFB3(1), TGFBR1(2), TGFBR3(5), TOB2(3)	7155105	26	25	26	11	2	5	7	8	4	0	0.867	1.000	1.000
589	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	AKR1A1(1), ECHS1(2), EHHADH(5), HADH(4), HADHA(3), HSD17B10(1), HSD17B4(5), NTAN1(1), SIRT1(2), SIRT2(1), SIRT5(2), SIRT7(1), VNN2(2)	9007518	30	24	30	11	0	10	10	5	5	0	0.716	1.000	1.000
590	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(2), ENO2(1), ENO3(3), FARS2(4), GOT1(1), GOT2(3), PAH(7), TAT(1), YARS(7)	6306436	29	24	29	11	0	9	11	3	6	0	0.603	1.000	1.000
591	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	13	CCND1(4), CDK4(5), CDKN1B(2), CFL1(2), E2F2(3), MDM2(2), PRB1(8)	5364510	26	24	26	11	1	7	9	5	4	0	0.825	1.000	1.000
592	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	8	CD3D(1), GZMB(2), ICAM1(6), ITGAL(7), ITGB2(4), PRF1(4)	5900376	24	23	24	12	5	5	4	2	8	0	0.649	1.000	1.000
593	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(3), ALPL(4), ALPP(3), ALPPL2(7), DHFR(3), FPGS(2), GGH(3)	4978860	25	23	25	11	3	2	13	3	4	0	0.769	1.000	1.000
594	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACOX1(1), ACOX3(2), ELOVL2(1), ELOVL5(1), ELOVL6(1), FADS1(1), FADS2(4), FASN(10), HADHA(3), SCD(1)	10918791	25	23	25	16	5	8	5	2	5	0	0.916	1.000	1.000
595	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3)	6074660	23	22	23	12	4	2	7	6	4	0	0.935	1.000	1.000
596	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3)	6074660	23	22	23	12	4	2	7	6	4	0	0.935	1.000	1.000
597	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(1), FDFT1(4), FDPS(2), HMGCR(4), IDI1(1), LSS(4), MVD(2), NQO1(3), PMVK(4)	8415959	25	22	25	10	10	7	2	2	4	0	0.440	1.000	1.000
598	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	10	CDK5(3), CDK5R1(1), EGR1(4), KLK2(2), MAP2K1(5), MAP2K2(6), NGFR(1), RAF1(3)	5378267	25	22	25	13	8	4	7	2	4	0	0.726	1.000	1.000
599	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GSS(3), NFKB1(5), NOX1(6), RELA(2), SOD1(1), XDH(6)	7528437	23	22	23	13	4	5	6	4	4	0	0.883	1.000	1.000
600	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(1), ALDH1B1(4), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), ALDH9A1(3), MIOX(4), UGDH(4)	6469482	22	22	22	10	4	3	4	8	3	0	0.785	1.000	1.000
601	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(3), PLCG1(8), PRKCA(7), PTK2B(4)	5101404	22	22	22	10	5	4	9	3	1	0	0.655	1.000	1.000
602	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	8	MMP14(4), MMP2(5), MMP9(1), RECK(10), TIMP1(1), TIMP2(1), TIMP4(1)	5385256	23	22	23	19	2	8	5	6	2	0	0.994	1.000	1.000
603	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(1), ASL(2), CPS1(13), GLS(1), GLUD1(4), GOT1(1)	5928982	22	22	22	10	4	5	5	5	3	0	0.801	1.000	1.000
604	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(5), CYP11A1(3), CYP11B2(4), CYP17A1(1), HSD11B2(3), HSD3B1(4), HSD3B2(4)	5250461	24	21	24	17	7	3	7	2	4	1	0.960	1.000	1.000
605	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(1), ACOX3(2), FADS2(4), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3)	7706334	24	21	24	14	3	6	8	1	6	0	0.916	1.000	1.000
606	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(5), CYP2A13(4), CYP2A6(2), CYP2A7(4), NAT1(2), XDH(6)	6066385	23	20	23	13	3	5	9	4	2	0	0.906	1.000	1.000
607	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	11	ACTA1(4), ACTR2(1), ARPC1B(3), ARPC2(2), ARPC3(1), ARPC4(1), CDC42(3), WASF1(3), WASL(2)	5844308	20	20	20	15	4	5	5	4	2	0	0.993	1.000	1.000
608	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAD(2), ALAS2(5), CPO(4), FECH(1), HBA2(2), UROD(1), UROS(4)	5939473	19	19	19	10	2	3	7	6	1	0	0.906	1.000	1.000
609	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CCL3(1), EPO(2), FLT3(6), IGF1(1), IL1A(1), IL3(1), IL6(2), IL9(2), KITLG(1), TGFB1(1), TGFB2(3), TGFB3(1)	6285319	22	19	22	11	6	2	7	5	2	0	0.850	1.000	1.000
610	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS1(2), DHRS2(4), DHRS3(1), DHRS7(1), ESCO1(4), ESCO2(4), SH3GLB1(2)	12617181	18	17	18	10	0	4	5	4	5	0	0.957	1.000	1.000
611	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	9	BAG4(6), BIRC3(2), FADD(4), RIPK1(2), TNFRSF1A(1), TNFRSF1B(2), TRADD(1), TRAF2(2)	5518937	20	17	20	10	5	5	6	3	1	0	0.735	1.000	1.000
612	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(2), ALDOA(1), ALDOB(5), ALDOC(4), TPI1(4)	2979765	16	16	16	7	1	6	4	5	0	0	0.692	1.000	1.000
613	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	CKM(3), EIF4E(1), GPT(1), LDHA(1), LDHB(1), LDHC(4), MAPK14(2), NCL(4)	6833447	17	16	17	10	3	2	4	4	4	0	0.949	1.000	1.000
614	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(4), EPHX2(4), HSD3B7(2), RDH11(2), RDH12(4)	3644574	16	15	16	7	3	3	7	3	0	0	0.695	1.000	1.000
615	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(6), SUCLA2(1)	1601806	7	7	7	4	0	2	4	1	0	0	0.831	1.000	1.000
616	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	5	BCL2(1), CASP3(2), CFL1(2), CFLAR(2)	2059462	7	7	7	5	2	5	0	0	0	0	0.743	1.000	1.000
