rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(3), ACADM(1), ACADS(3), ACAT1(1), ECHS1(3), HADHA(4)	5419468	15	15	14	0	3	2	4	5	0	1	0.00868	0.0247	1.000
2	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(3), GOT1(3), GOT2(2), TAT(2), TYR(5)	4732052	15	15	15	1	2	1	3	4	5	0	0.149	0.0371	1.000
3	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(2), ECHS1(3), EHHADH(6), HADHA(4)	4888973	15	15	14	1	1	3	4	4	3	0	0.0385	0.0443	1.000
4	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	3	CD28(1), HLA-DRA(1), HLA-DRB1(6)	1241979	8	7	8	2	1	2	1	2	2	0	0.579	0.0600	1.000
5	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(8), PDXK(2), PDXP(2), PSAT1(2)	4789589	14	14	14	1	3	1	1	6	3	0	0.147	0.0666	1.000
6	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(2), AASDH(5), AASDHPPT(3), AASS(8)	7059407	18	18	18	0	0	4	4	6	4	0	0.0127	0.0750	1.000
7	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(3), CD3E(1), CD3G(2), HLA-A(6), ICAM1(3), ITGAL(7), ITGB2(2), PRF1(1)	8328704	25	24	25	2	1	5	3	10	5	1	0.0302	0.0762	1.000
8	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(2), RANBP2(27), RANGAP1(1)	8187800	30	27	24	3	1	7	4	8	10	0	0.0388	0.0762	1.000
9	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(2), AASDHPPT(3), AASS(8)	4802785	13	13	13	0	0	3	3	4	3	0	0.0402	0.0792	1.000
10	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(3), ACAT1(1), ECHS1(3), EHHADH(6), HADHA(4), HADHB(4)	8443021	21	21	20	1	1	4	5	8	3	0	0.0143	0.105	1.000
11	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(1), ASL(4), CPS1(5), GLS(6), GOT1(3)	7769460	19	19	19	1	0	4	2	7	6	0	0.0803	0.135	1.000
12	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(2), ARG1(1), GLS(6), OAT(2), PRODH(3)	5565788	14	14	14	0	1	2	5	3	3	0	0.0256	0.137	1.000
13	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(3), ICAM1(3), ITGAL(7), ITGAM(9), ITGB2(2), SELE(5), SELL(2)	10626766	31	31	31	4	2	9	5	8	7	0	0.0287	0.144	1.000
14	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(3), GOT2(2), TAT(2)	2651351	7	7	7	1	1	1	2	0	3	0	0.424	0.211	1.000
15	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCR3(2), HLA-DRA(1), HLA-DRB1(6), IL3(1)	2792284	10	9	10	2	0	2	2	2	4	0	0.527	0.231	1.000
16	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(7), EGF(5), EGFR(9), HGS(3), RAB5A(1), TFRC(3)	12803255	28	27	26	0	5	1	5	9	8	0	0.00225	0.237	1.000
17	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(1), RAB11A(1), RAB1A(3), RAB3A(2), RAB4A(1), RAB5A(1), RAB6A(1)	4248633	10	10	10	1	1	1	2	3	3	0	0.261	0.265	1.000
18	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	9	ACAT1(1), ECHS1(3), EHHADH(6), HADHA(4), SDHB(1)	6937189	15	15	14	1	1	3	4	5	2	0	0.0494	0.284	1.000
19	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	9	ACACA(9), CPT1A(2), LEP(1), LEPR(5), PRKAA1(1), PRKAB1(1), PRKAG1(5), PRKAG2(6)	13517197	30	29	30	2	2	6	8	6	8	0	0.00390	0.290	1.000
20	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1	CMBL(1)	513607	1	1	1	0	0	0	0	0	1	0	1.000	0.332	1.000
21	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	12	ARF1(1), ARF3(3), CDK2(2), CDK4(6), CDKN1A(3), CDKN1B(1), CFL1(1), E2F1(1), E2F2(1)	6289236	19	19	16	3	0	0	3	5	10	1	0.638	0.334	1.000
22	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3E(1), CD3G(2)	1171958	3	3	3	0	0	0	1	1	1	0	0.585	0.344	1.000
23	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ECHS1(3), HADH(1), HADHA(4), HADHB(4), HSD17B4(1), MECR(4), PPT1(1)	8470284	18	17	18	1	2	3	5	7	1	0	0.0259	0.345	1.000
24	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	14	AKT1(2), AKT2(5), AKT3(3), GRB2(2), ILK(4), MAPK3(3), PDK1(1), PIK3CD(2), PTK2B(3), RBL2(5), SHC1(4), SOS1(8)	17214478	42	38	40	3	6	8	5	11	12	0	0.00360	0.358	1.000
25	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	17	ABCB1(4), AKT1(2), ATM(19), CDKN1A(3), CPB2(6), CSNK1A1(2), FHL2(1), HIF1A(4), IGFBP3(1), NFKBIB(2)	19418629	44	39	40	3	3	4	4	14	17	2	0.0123	0.360	1.000
26	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GGT1(4), SHMT1(2), SHMT2(5)	4094910	11	11	11	2	1	1	2	4	3	0	0.404	0.366	1.000
27	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	6	HDAC1(2), MAX(5), MYC(1), SP1(2), SP3(2), WT1(3)	6102798	15	15	15	2	0	1	0	7	7	0	0.523	0.372	1.000
28	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	10	CD2(2), CD28(1), CD3E(1), CD3G(2), ICAM1(3), ITGAL(7), ITGB2(2), PTPRC(8)	10274303	26	25	26	3	2	3	3	11	7	0	0.103	0.374	1.000
29	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	12	CD2(2), CD34(2), CD3E(1), CD3G(2), CD58(1), CD8A(1), IL3(1), KITLG(2)	5333673	12	11	12	1	1	1	2	4	4	0	0.282	0.402	1.000
30	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	5	CCR5(1), CD28(1), CD3E(1), CD3G(2)	2342928	5	5	5	1	1	0	1	2	1	0	0.608	0.407	1.000
31	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(2), LIPT1(1)	1538815	3	3	3	1	0	0	0	2	1	0	0.815	0.420	1.000
32	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(2), CD28(1), CD3E(1), CD3G(2), CD8A(1), ICAM1(3), ITGAL(7), ITGB2(2), PTPRC(8)	10584486	27	25	27	3	2	4	3	11	7	0	0.0747	0.434	1.000
33	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(3), GPD2(1), NDUFA1(1), SDHA(9), SDHB(1), SDHD(2), UQCRC1(1)	6536667	18	16	18	3	3	7	3	5	0	0	0.101	0.435	1.000
34	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	9	CD3E(1), CD3G(2), FYN(2), HLA-DRA(1), HLA-DRB1(6), LCK(1), PTPRC(8), ZAP70(1)	7855602	22	20	22	3	1	3	2	10	6	0	0.245	0.440	1.000
35	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	14	AKT1(2), AKT2(5), AKT3(3), CDKN1A(3), ELK1(1), GRB2(2), HRAS(1), MAP2K2(1), NGFR(1), NTRK1(7), PIK3CD(2), SHC1(4), SOS1(8)	13672505	40	37	39	5	3	7	3	18	8	1	0.0281	0.450	1.000
36	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(6), GLS2(4), GLUD2(7)	4425638	17	17	15	4	1	2	3	9	2	0	0.507	0.454	1.000
37	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(2), CDK2(2), CDKN1B(1), CUL1(5), E2F1(1), NEDD8(2), RB1(4), RBX1(1), SKP2(1)	8675384	19	19	18	2	1	1	4	2	9	2	0.202	0.488	1.000
38	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	7	CD28(1), CD80(1), HLA-DRA(1), HLA-DRB1(6), IL4(1)	2846625	10	9	10	3	2	2	2	2	2	0	0.574	0.490	1.000
39	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(1)	726871	1	1	1	1	0	0	1	0	0	0	0.957	0.493	1.000
40	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(2), PGLYRP2(3)	1715205	5	5	5	2	1	1	1	2	0	0	0.717	0.495	1.000
41	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(7), CCNE1(2), CDK2(2), CUL1(5), E2F1(1), RB1(4), SKP2(1)	8733824	22	22	19	3	1	2	4	2	11	2	0.196	0.536	1.000
42	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ5(2), COQ6(1), COQ7(1), NDUFA13(2), NDUFB11(1)	4130964	7	7	7	1	3	1	0	1	2	0	0.379	0.541	1.000
43	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CCNE1(2), CDK2(2), CUL1(5), E2F1(1), FBXW7(6), RB1(4)	8487807	20	20	20	3	1	2	5	2	8	2	0.257	0.554	1.000
44	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(5), BMPR1A(1), BMPR1B(2), BMPR2(5)	6194918	13	11	13	0	0	2	3	5	3	0	0.0167	0.605	1.000
45	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	11	CCNA1(7), CCNE1(2), CCNE2(4), CDK2(2), CDK4(6), CDKN1B(1), E2F1(1), E2F2(1)	7808941	24	20	17	3	0	3	4	3	14	0	0.260	0.624	1.000
46	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(3), ICAM1(3), ITGA4(3), ITGAL(7), ITGB1(7), ITGB2(2), SELE(5), SELL(2)	12218157	32	31	32	5	1	9	6	8	8	0	0.0811	0.635	1.000
47	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM2(1), CAMK1(3), CAMK1G(3), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(3), CAMKK1(4), CAMKK2(3), SYT1(1)	11606698	23	23	22	2	2	3	4	7	7	0	0.0708	0.636	1.000
48	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	AKR1A1(2), ECHS1(3), EHHADH(6), HADH(1), HADHA(4), HSD17B4(1), NTAN1(1), SIRT1(5), SIRT5(1), SIRT7(2), VNN2(1)	11898675	27	26	26	4	3	5	5	6	8	0	0.0814	0.641	1.000
49	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(6), CTH(2), GOT1(3), GOT2(2), LDHB(2), LDHC(3), MPST(2)	6773580	20	20	18	4	1	0	3	6	10	0	0.644	0.641	1.000
50	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	CASP7(1), DFFA(1), DFFB(1), HMGB1(3), HMGB2(3), TOP2A(5), TOP2B(6)	10113287	20	19	20	2	3	3	2	5	6	1	0.201	0.643	1.000
51	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(5), EGFR(9), ERBB3(6), NRG1(3), UBE2D1(2)	10301766	25	25	23	4	4	2	2	8	9	0	0.260	0.644	1.000
52	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(1), HMGCL(2), OXCT1(2)	3424685	5	5	5	1	0	1	0	2	2	0	0.588	0.645	1.000
53	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	GRB2(2), HRAS(1), PTK2B(3), SHC1(4), SOS1(8), SRC(3)	8688524	21	19	21	3	1	7	1	7	5	0	0.149	0.649	1.000
54	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	11	CBL(3), CSF1R(6), EGF(5), EGFR(9), GRB2(2), PDGFRA(6), PRKCA(2), SH3GLB1(3), SH3GLB2(1), SH3KBP1(3), SRC(3)	16619090	43	39	41	5	4	7	5	14	13	0	0.0507	0.657	1.000
55	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(1), HGD(3)	2260400	4	4	4	1	0	0	1	0	3	0	0.830	0.663	1.000
56	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(5), ENO2(1), ENO3(2), GOT1(3), GOT2(2), PAH(5), TAT(2), YARS(1)	8346172	21	19	21	3	2	2	5	5	7	0	0.165	0.664	1.000
57	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(2), CAMP(1), DAG1(3), ITPKA(1), ITPKB(3)	5726775	10	9	10	1	2	1	2	0	5	0	0.328	0.703	1.000
58	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(3), ICAM1(3), ITGA4(3), ITGAL(7), ITGAM(9), ITGB1(7), ITGB2(2), SELE(5), SELL(2), SELP(2)	16189587	43	41	43	7	2	11	8	12	10	0	0.0531	0.711	1.000
59	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	17	CBL(3), EGF(5), EGFR(9), GRB2(2), HRAS(1), MAPK3(3), PTPRB(5), RAF1(4), RASA1(7), SHC1(4), SOS1(8), SPRY1(1), SPRY2(3), SRC(3)	24503919	58	52	56	6	4	14	8	18	14	0	0.00569	0.723	1.000
60	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(3), HPRT1(1), IMPDH1(1), MTHFD2(2), POLB(2), POLD1(7), POLG(6), PRPS2(4), RRM1(2)	12380440	28	27	26	3	2	5	2	10	9	0	0.0999	0.727	1.000
61	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(1), IARS(4), LARS(7), LARS2(2), PDHA1(1), PDHA2(3), PDHB(1)	10131170	19	17	19	2	2	3	3	5	6	0	0.134	0.727	1.000
62	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(2), FDPS(1), IDI1(1), IDI2(2), SQLE(1)	4384154	7	7	7	1	1	1	0	2	3	0	0.552	0.732	1.000
63	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(2), GNAS(6), GNB1(3), PRKACA(2), PRKAR1A(2)	6330917	15	15	15	3	2	1	1	10	1	0	0.512	0.735	1.000
64	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(3), ALPL(4), ALPP(5), ALPPL2(5), FPGS(3), GGH(2)	6105520	22	20	22	6	4	5	4	7	2	0	0.233	0.738	1.000
65	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	9	CCR3(2), HLA-DRA(1), HLA-DRB1(6), IL1B(1), IL4(1), IL5RA(2)	4231158	13	12	13	4	1	3	3	2	4	0	0.702	0.743	1.000
66	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(1), CR1(8), CR2(4), HLA-DRA(1), HLA-DRB1(6), ICAM1(3), ITGAL(7), ITGB2(2), PTPRC(8)	15076622	40	38	40	7	4	5	3	17	11	0	0.202	0.756	1.000
67	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	FOSB(2), GRIA2(4), PPP1R1B(1)	3691951	7	7	7	2	1	1	1	3	1	0	0.649	0.760	1.000
68	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	5	GBA(3), GGT1(4), SHMT1(2), SHMT2(5)	4912337	14	14	14	4	1	1	2	6	4	0	0.628	0.773	1.000
69	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(2), FDPS(1), IDI1(1), SQLE(1)	3294606	5	5	5	1	0	1	0	2	2	0	0.743	0.777	1.000
70	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(3), F13B(4), HSD17B1(1), HSD17B2(1), HSD17B4(1), HSD17B7(1), HSD3B1(1)	8078703	12	11	12	1	2	3	2	4	1	0	0.103	0.783	1.000
71	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDOA(2), ALDOB(3), ALDOC(1), TPI1(2)	3865278	8	8	8	4	0	0	3	0	5	0	0.973	0.802	1.000
72	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	10	ACLY(8), ACO1(5), ACSS1(3), ACSS2(7), FH(2), IDH1(2), MDH1(2), MDH2(1), SUCLA2(2)	12531428	32	27	31	5	1	5	3	11	11	1	0.156	0.803	1.000
73	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALT(3), UGDH(1), UXS1(1)	3998272	5	5	5	1	0	1	3	1	0	0	0.500	0.806	1.000
74	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(1), CDC25B(1), CDKN1A(3), CHEK1(1), NEK1(3), WEE1(2)	7392778	11	10	11	1	0	2	0	5	3	1	0.314	0.810	1.000
75	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	5	ABCB1(4), ABCB11(4), ABCB4(8), ABCC3(8), GSTP1(2)	11495894	26	25	23	4	1	4	7	7	7	0	0.138	0.814	1.000
76	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(1), CD3E(1), CD3G(2), IL2RA(2), IL4(1), TGFB2(2), TGFBR1(1), TGFBR2(2), TGFBR3(3), TOB1(5), TOB2(3)	10680453	23	23	23	4	1	3	6	7	6	0	0.232	0.815	1.000
77	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	HLCS(2), SPCS1(2)	3085202	4	4	4	1	0	0	1	2	1	0	0.669	0.819	1.000
78	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(8), AGT(4), AGTR1(2), AGTR2(1), BDKRB2(1), KNG1(4), NOS3(3), REN(1)	9667579	24	23	22	4	2	4	2	9	7	0	0.197	0.823	1.000
79	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	8	ACO1(5), FH(2), IDH1(2), MDH1(2), MDH2(1), SDHB(1), SUCLA2(2)	8155773	15	15	15	3	1	2	1	7	4	0	0.325	0.843	1.000
80	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(1), CYP2C9(1)	2032463	2	2	2	1	0	0	0	1	1	0	0.774	0.843	1.000
81	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	8	ALDH1B1(4), ALDH2(4), ALDH3A2(2), ALDH7A1(1), MIOX(2), UGDH(1)	7499731	14	14	14	3	1	3	4	3	3	0	0.363	0.845	1.000
82	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(5), FOS(1), GRB2(2), HRAS(1), IL3(1), JAK2(7), MAPK3(3), PTPN6(3), RAF1(4), SHC1(4), SOS1(8), STAT5A(3), STAT5B(3)	17543882	45	42	44	6	6	4	7	16	12	0	0.0570	0.851	1.000
83	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNGR1(3), IFNGR2(2), JAK1(6), JAK2(7), STAT1(5)	8316258	23	23	23	5	3	0	3	10	7	0	0.552	0.852	1.000
84	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALT(3), UGDH(1), UGP2(1), UXS1(1)	5057310	6	6	6	1	0	1	4	1	0	0	0.382	0.856	1.000
85	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA1(1), NDUFA10(1), NDUFA11(2), NDUFB2(2), NDUFB4(1), NDUFB5(3), NDUFB6(1), NDUFB7(1), NDUFS1(8), NDUFS2(1), NDUFV1(2), NDUFV2(1)	7042130	24	24	23	5	0	1	3	10	10	0	0.541	0.858	1.000
86	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(5), ATIC(2), GART(4), MTHFD1(7), MTHFD1L(4), MTHFD2(2), MTHFR(1), SHMT1(2), SHMT2(5), TYMS(1)	17963465	33	32	33	4	3	6	3	15	6	0	0.0580	0.867	1.000
87	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(2), EPHX2(1), RDH11(4), RDH13(1)	4715015	8	8	8	2	1	0	1	6	0	0	0.595	0.874	1.000
88	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BAG4(1), BIRC3(5), CASP8(1), RIPK1(1), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TRADD(2), TRAF2(1)	8049816	14	14	14	3	0	4	4	4	2	0	0.386	0.877	1.000
89	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	14	APAF1(3), ATM(19), CCNE1(2), CDK2(2), CDK4(6), CDKN1A(3), E2F1(1), PCNA(3), RB1(4)	17036308	43	37	39	6	2	3	5	9	21	3	0.190	0.885	1.000
90	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GSR(1), GSS(1), NFKB1(2), NOX1(7), RELA(6), TNF(1), XDH(6)	9878723	24	21	19	3	1	2	5	5	10	1	0.331	0.887	1.000
91	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(6), CYP51A1(2), DHCR24(1), DHCR7(3), FDFT1(2), FDPS(1), GGCX(2), HSD17B7(1), IDI1(1), IDI2(2), LSS(4), MVK(1), NSDHL(3), PMVK(1), SQLE(1), TM7SF2(3), VKORC1(1)	19285921	35	32	33	2	2	5	2	14	12	0	0.0165	0.889	1.000
92	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(1)	1643608	1	1	1	0	0	0	0	1	0	0	0.838	0.889	1.000
93	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	MTMR1(2), MTMR2(3), MTMR6(1), NFS1(1), PHPT1(1), THTPA(1), TPK1(1)	6441584	10	10	10	2	1	2	2	5	0	0	0.387	0.898	1.000
94	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	10	ARSB(1), GALNS(6), GLB1(5), GNS(4), GUSB(5), HEXA(4), IDS(2), LCT(7), NAGLU(2)	13652659	36	32	36	7	5	5	4	11	11	0	0.180	0.906	1.000
95	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	NRF1(1), UBE2A(2), UBE2D1(2), UBE2D2(1), UBE2D3(2), UBE2H(2), UBE2I(1), UBE2J1(1), UBE2J2(1), UBE2L3(1), UBE2N(2), UBE3A(2)	10471665	18	18	18	3	1	2	2	9	4	0	0.296	0.906	1.000
96	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(3), FDFT1(2), FDPS(1), IDI1(1), LSS(4), MVK(1), NQO2(1), PMVK(1), SQLE(1), VKORC1(1)	11094202	16	16	16	1	0	2	2	7	5	0	0.115	0.909	1.000
97	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(4), CYP2E1(1), NR1I3(1), PTGS1(2), PTGS2(5)	5259683	13	13	13	4	2	1	2	4	3	1	0.702	0.913	1.000
98	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	B3GNT1(2), FUT2(2), GCNT2(3), ST8SIA1(2)	5908503	9	9	9	2	2	1	1	5	0	0	0.393	0.919	1.000
99	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(1), CCNH(1), CDC25A(1), CDC25B(1), CDC25C(3), MNAT1(1), SHH(3), XPO1(7)	8685207	18	18	18	4	1	2	7	6	2	0	0.298	0.922	1.000
100	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(6), F13A1(3), F2(3), F2R(2), FGA(4), FGB(3), FGG(6), PLAT(4), PLG(8), SERPINB2(1)	13504810	40	37	35	8	6	3	5	15	11	0	0.219	0.923	1.000
101	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	10	C1QA(1), C1R(4), C2(4), C3(8), C5(6), C6(3), C7(4), C8A(1)	16103490	31	29	29	4	4	4	2	14	6	1	0.110	0.928	1.000
102	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	AOC2(4), AOC3(2), CES1(8), ESD(1)	5734455	15	15	13	4	0	2	3	5	5	0	0.535	0.932	1.000
103	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(1), GPR161(2), GPR171(1), GPR18(2), GPR39(2), GPR45(3), GPR65(5), GPR75(1)	9703900	17	17	17	4	3	4	0	7	2	1	0.212	0.933	1.000
104	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(2), CSAD(3), GAD1(2), GAD2(2), GGT1(4)	5683713	13	13	13	4	2	1	5	2	3	0	0.505	0.934	1.000
105	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	8	ALDOB(3), ENO1(5), HK1(6), PFKL(3), PGK1(3), PKLR(1), TPI1(2)	7884201	23	22	23	6	4	3	3	6	7	0	0.331	0.935	1.000
106	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	ANP32A(4), APEX1(2), CREBBP(9), DFFA(1), DFFB(1), HMGB2(3), PRF1(1)	10462724	21	20	21	4	4	3	5	2	7	0	0.122	0.938	1.000
107	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(2), CHRNA1(3), STX1A(1), VAMP2(1)	3211172	7	6	7	4	0	1	0	3	3	0	0.937	0.939	1.000
108	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	CYP51A1(2), DHCR7(3), FDFT1(2), FDPS(1), HMGCS1(2), IDI1(1), LSS(4), MVK(1), NSDHL(3), PMVK(1), SQLE(1)	13226697	21	18	21	1	0	4	2	8	7	0	0.0474	0.948	1.000
109	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(2), CYP11A1(2), CYP11B2(2), CYP17A1(3), HSD11B2(1), HSD3B1(1)	6759353	11	9	11	2	1	0	1	9	0	0	0.380	0.949	1.000
110	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(5), GABBR1(5), GPRC5A(2), GPRC5B(2), GPRC5C(1), GPRC5D(1), GRM1(4), GRM2(5), GRM3(5), GRM4(6), GRM5(8), GRM7(5), GRM8(3)	19738245	52	45	49	9	8	8	5	19	12	0	0.0934	0.949	1.000
111	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	11	ALDH1A1(1), ALDH1A2(1), ALDH1B1(4), ALDH2(4), ALDH3A2(2), ECHS1(3), EHHADH(6), HADHA(4)	11162719	25	25	24	5	2	5	7	8	3	0	0.153	0.950	1.000
112	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	8	HRAS(1), MMP14(1), MMP2(6), MMP9(1), RECK(1), TIMP2(1)	7118269	11	11	11	3	2	2	1	3	3	0	0.558	0.952	1.000
113	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(2), POLD1(7), POLE(5), POLG(6), POLL(2), POLQ(14)	16460708	36	33	34	4	3	1	2	14	16	0	0.183	0.955	1.000
114	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNA1(1), IFNAR1(3), IFNB1(2), JAK1(6), STAT1(5), STAT2(7), TYK2(7)	10778339	31	26	30	7	4	5	4	7	11	0	0.242	0.955	1.000
115	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(21), MAP2(4), PPP1CA(1), PPP2CA(1), PRKACB(2), PRKACG(2), PRKAG1(5), PRKAR2A(1), PRKAR2B(3), PRKCE(4)	18075505	44	41	41	7	5	3	3	17	15	1	0.147	0.960	1.000
116	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	28	ATG12(1), ATG3(1), ATG7(6), BECN1(2), IFNA1(1), IFNA14(1), IFNA16(2), IFNA2(1), IFNA21(3), IFNA5(1), IFNA7(3), IFNA8(2), INS(1), PIK3C3(4), PIK3R4(5), PRKAA1(1), ULK1(2), ULK2(3), ULK3(3)	20079890	43	41	43	7	4	3	3	24	9	0	0.210	0.960	1.000
117	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	DCN(3), FMOD(3), KERA(1), LUM(1)	3580606	8	8	8	3	0	1	0	5	2	0	0.790	0.962	1.000
118	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(3), DCXR(1), GUSB(5), RPE(2), UCHL1(1), UCHL3(1), UGDH(1), UGT1A1(5), UGT1A3(1), UGT1A4(2), UGT1A5(2), UGT1A6(3), UGT1A7(3), UGT1A9(5), UGT2B15(1), UGT2B4(4)	17550099	40	36	40	7	3	6	10	9	12	0	0.147	0.964	1.000
119	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	16	ADCY1(2), GNAS(6), GNB1(3), PPP2CA(1), PRKAA1(1), PRKAB1(1), PRKACB(2), PRKACG(2), PRKAG1(5), PRKAG2(6), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3)	14024223	35	35	35	6	5	3	2	15	10	0	0.168	0.965	1.000
120	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	19	B2M(3), HLA-A(6), ITGB1(7), KLRC1(3), KLRC2(3), KLRC3(2), MAPK3(3), PAK1(3), PIK3R1(5), PTK2B(3), PTPN6(3), SYK(2), VAV1(4)	16512172	47	40	46	9	3	7	5	14	16	2	0.353	0.968	1.000
121	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYA(1), NFYC(2), RB1(4), SP1(2), SP3(2)	6742291	11	11	11	3	0	2	0	2	5	2	0.835	0.972	1.000
122	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	12	ACAA1(3), ACOX1(2), ACOX3(5), ELOVL2(1), ELOVL6(1), FADS1(1), FADS2(2), FASN(9), HADHA(4), PECR(4)	13539916	32	26	32	5	4	8	2	16	2	0	0.0445	0.974	1.000
123	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(1), EPHA4(2), EPHB1(4), FYN(2), ITGA1(8), ITGB1(7), L1CAM(5), LYN(1), SELP(2)	15696413	32	31	30	5	4	4	2	13	9	0	0.173	0.975	1.000
124	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	8	CHUK(2), DNAJC3(2), EIF2S2(2), NFKB1(2), NFKBIA(2), RELA(6)	9173529	16	16	13	3	1	4	0	4	6	1	0.483	0.975	1.000
125	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(1), ACP2(1), ACP5(2), ENPP1(4), ENPP3(2), FLAD1(4), TYR(5)	9661735	19	18	19	4	0	4	0	11	4	0	0.506	0.978	1.000
126	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(1), FOSL2(1), IFNAR1(3), IFNB1(2), NFKB1(2), RELA(6), TRAF6(2)	10827165	17	17	14	3	2	5	0	2	7	1	0.421	0.979	1.000
127	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	7	ALDH1A1(1), ALDH1A2(1), ALDH1B1(4), ALDH2(4), ALDH3A2(2)	6952456	12	12	12	4	1	2	4	4	1	0	0.604	0.979	1.000
128	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	7	ALDH1A1(1), ALDH1A2(1), ALDH1B1(4), ALDH2(4), ALDH3A2(2)	6952456	12	12	12	4	1	2	4	4	1	0	0.604	0.979	1.000
129	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(2), ERBB4(10), NRG2(3), NRG3(5), PRKCA(2)	9122312	22	22	22	5	3	4	3	9	3	0	0.356	0.980	1.000
130	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	13	C1QA(1), C1R(4), C2(4), C3(8), C5(6), C6(3), C7(4), C8A(1), MASP1(4), MASP2(1), MBL2(2)	19971730	38	36	36	5	6	5	3	16	7	1	0.0610	0.981	1.000
131	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(1), CCL2(1), LDLR(3), LPL(3)	5223024	8	8	8	3	0	2	0	4	2	0	0.679	0.983	1.000
132	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(8), C5(6), C6(3), C7(4), C8A(1)	12856880	22	21	22	4	2	2	2	12	4	0	0.327	0.983	1.000
133	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(1), F2(3), F2R(2), F5(11), F7(1), FGA(4), FGB(3), FGG(6), PROC(3), PROS1(5), TFPI(2)	16338029	41	39	39	8	5	3	3	14	15	1	0.284	0.983	1.000
134	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(4), POLR2A(13), POLR2B(7), POLR2F(4), POLR2I(1), POLR2J(1), POLRMT(5)	13160936	35	34	32	7	4	5	6	9	11	0	0.227	0.984	1.000
135	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	7	CS(2), FH(2), MDH1(2), OGDH(8), SDHA(9), SUCLA2(2)	8631859	25	23	25	7	1	8	0	11	5	0	0.440	0.984	1.000
136	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(5), CS(2), GRHPR(2), HAO1(1), MDH1(2), MDH2(1), MTHFD1(7), MTHFD1L(4), MTHFD2(2)	13478748	26	26	26	5	3	3	3	13	4	0	0.238	0.984	1.000
137	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(2), CDKN1A(3), EPOR(3), GRIN1(2), HIF1A(4), JAK2(7), NFKB1(2), NFKBIA(2), RELA(6)	12667776	31	29	28	6	1	4	4	10	9	3	0.360	0.985	1.000
138	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CCL3(1), FLT3(6), IL3(1), IL9(1), KITLG(2), TGFB2(2)	8353125	13	13	13	3	0	1	3	4	5	0	0.665	0.985	1.000
139	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(5), CS(2), GRHPR(2), HAO1(1), MDH1(2), MDH2(1), MTHFD1(7), MTHFD1L(4), MTHFD2(2)	12849668	26	26	26	5	3	3	3	13	4	0	0.238	0.985	1.000
140	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(1), ALDH1A2(1), RDH5(4)	3854221	6	6	6	3	0	0	4	1	1	0	0.857	0.987	1.000
141	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	6	CD36(1), FOS(1), FYN(2), JUN(2), MAPK14(1)	4844162	7	7	7	3	1	1	0	4	1	0	0.887	0.987	1.000
142	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	16	CD28(1), CD3E(1), CD3G(2), CD80(1), CD86(3), CTLA4(3), GRB2(2), HLA-DRA(1), HLA-DRB1(6), ICOS(3), ITK(1), LCK(1), PIK3R1(5), PTPN11(2)	10445296	32	31	31	7	4	6	3	10	9	0	0.505	0.990	1.000
143	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(2), IFNGR1(3), JAK1(6), JAK2(7), PTPRU(4), STAT1(5)	11401408	27	25	27	6	4	0	3	14	6	0	0.498	0.990	1.000
144	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(3)	3068084	3	3	3	2	0	1	0	2	0	0	0.956	0.991	1.000
145	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(2), GNB1(3), HTR2C(1), PLCB1(3), TUB(3)	7113832	12	11	12	3	1	2	0	7	2	0	0.565	0.991	1.000
146	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(1), CHAT(5), PCYT1A(1), PDHA1(1), PDHA2(3), SLC18A3(2)	6617312	13	13	11	4	1	2	1	3	6	0	0.801	0.991	1.000
147	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	12	C1QA(1), C1R(4), C2(4), C3(8), C5(6), C6(3), C7(4), C8A(1), C8B(1), MASP1(4)	19418108	36	34	34	5	7	4	2	15	7	1	0.0888	0.992	1.000
148	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	13	AKR1B10(2), DHRS2(1), PON2(2), PON3(5), RDH11(4), RDH13(1)	8273385	15	15	14	4	2	0	3	7	3	0	0.683	0.992	1.000
149	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDK(1), CTH(2), MUT(2)	4850611	5	5	5	2	1	0	1	1	2	0	0.890	0.992	1.000
150	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	B3GALNT1(1), B3GALT5(3), FUT2(2), GBGT1(2), GLA(1), HEXA(4), ST3GAL1(2), ST8SIA1(2)	10462880	17	16	17	4	3	3	2	7	2	0	0.280	0.992	1.000
151	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	22	ACP1(1), ACP2(1), ACP5(2), ACP6(3), ALPI(3), ALPL(4), ALPP(5), ALPPL2(5), CMBL(1), CYP3A43(2), CYP3A5(1), CYP3A7(2), DHRS2(1), PON2(2), PON3(5)	17063096	38	36	36	8	4	7	4	14	9	0	0.227	0.993	1.000
152	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	FUT2(2), FUT3(2), FUT6(4), ST3GAL3(3)	4672695	11	10	9	4	4	1	0	3	3	0	0.766	0.993	1.000
153	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(2), ADH1B(2), ADH4(2), ADH6(2), ADHFE1(3)	5684384	11	11	10	5	1	0	0	7	3	0	0.932	0.993	1.000
154	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(3), LPO(1), MPO(6), PRDX1(1), PRDX5(1), PRDX6(2), TPO(4), TYR(5)	9594681	23	22	23	5	1	2	6	8	6	0	0.391	0.993	1.000
155	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(1), HMOX1(3), IL10RA(4), JAK1(6), STAT1(5), STAT3(3), STAT5A(3), TNF(1)	12086486	26	26	25	5	4	0	1	11	10	0	0.649	0.993	1.000
156	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOA(2), ALDOB(3), ALDOC(1), GOT1(3), GOT2(2), GPT(4), GPT2(2), MDH1(2), MDH2(1), ME1(1), ME3(2), PGK1(3), PGK2(1), PKLR(1), RPE(2), RPIA(2), TKT(2), TKTL1(2), TKTL2(5), TPI1(2)	19919703	43	42	43	8	2	5	8	11	17	0	0.261	0.994	1.000
157	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(4), ANKRD1(1), ATF3(1), EIF4E(2), EIF4EBP1(1), IFRD1(1), IL1R1(3), NR4A3(2), WDR1(2)	10856714	17	17	17	4	1	4	4	5	3	0	0.393	0.994	1.000
158	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	8	ALAS1(5), ALAS2(5), FECH(2), PPOX(2), UROD(2)	6985769	16	16	15	8	1	1	3	6	5	0	0.900	0.994	1.000
159	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOA(2), ALDOB(3), ALDOC(1), GOT1(3), GOT2(2), GPT(4), GPT2(2), MDH1(2), MDH2(1), ME1(1), ME2(3), ME3(2), PGK1(3), PKLR(1), RPE(2), RPIA(2), TKT(2), TPI1(2)	17800341	38	36	38	7	2	5	8	7	16	0	0.256	0.994	1.000
160	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(6), POLR1B(4), POLR1C(2), POLR1D(1), POLR2A(13), POLR2B(7), POLR2F(4), POLR2I(1), POLR2J(1), POLR3A(5), POLR3B(5), POLR3G(1), POLR3H(1), POLR3K(1)	23473829	52	48	49	8	5	7	4	22	14	0	0.0876	0.994	1.000
161	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(2), GAD1(2), HDC(1), TH(4), TPH1(2)	5828899	11	11	11	4	2	2	3	2	2	0	0.692	0.995	1.000
162	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(1), ACP2(1), ACP5(2), ACP6(3), ENPP1(4), ENPP3(2), FLAD1(4), MTMR1(2), MTMR2(3), MTMR6(1), PHPT1(1), TYR(5)	15026149	29	28	28	5	0	6	1	18	4	0	0.275	0.995	1.000
163	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(2), IL4R(4), JAK1(6), JAK2(7), TYK2(7)	10359495	26	25	25	8	3	0	5	8	10	0	0.738	0.995	1.000
164	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(2), IL4R(4), JAK1(6), JAK2(7), TYK2(7)	10359495	26	25	25	8	3	0	5	8	10	0	0.738	0.995	1.000
165	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	CASP8(1), CFL1(1), CFLAR(1)	3849704	3	3	3	2	0	0	2	0	1	0	0.942	0.996	1.000
166	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(2), LDLR(3), MBTPS1(3), MBTPS2(1), SCAP(4), SREBF1(4), SREBF2(8)	11734006	25	25	25	6	2	4	5	6	8	0	0.453	0.996	1.000
167	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	PAPSS1(2), PAPSS2(4), SULT1E1(2), SULT2A1(1), SUOX(4)	6145351	13	13	13	5	1	2	4	2	4	0	0.708	0.996	1.000
168	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(3), IFNB1(2), JAK1(6), PTPRU(4), STAT1(5), STAT2(7), TYK2(7)	12301259	34	29	33	8	5	4	4	10	11	0	0.276	0.996	1.000
169	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(1), BDH1(1), BDH2(1), HMGCL(2), HMGCS1(2), HMGCS2(1), OXCT1(2)	7281201	10	10	10	3	0	2	1	5	2	0	0.674	0.996	1.000
170	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(8), CS(2), MDH1(2), ME1(1), PC(8), PDHA1(1), SLC25A1(1), SLC25A11(1)	9156149	24	23	24	6	1	3	1	10	9	0	0.530	0.996	1.000
171	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	11	ATM(19), CDC25A(1), CDC25B(1), CDC25C(3), CDK2(2), CDK4(6), CHEK1(1), MYT1(5), RB1(4), WEE1(2)	16965061	44	39	40	9	2	4	6	14	16	2	0.392	0.996	1.000
172	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	ALDOA(2), CTSD(3), GREB1(16), HSPB2(2), MTA1(4), MTA3(3), PDZK1(1)	10599857	31	28	29	8	1	2	7	14	7	0	0.688	0.996	1.000
173	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	36	ANPEP(8), G6PD(2), GCLC(4), GGT1(4), GPX6(1), GSR(1), GSS(1), GSTA1(1), GSTA2(1), GSTA3(1), GSTA4(1), GSTA5(1), GSTK1(1), GSTM1(2), GSTM2(1), GSTM4(1), GSTM5(1), GSTP1(2), GSTT1(2), IDH1(2), OPLAH(7), TXNDC12(1)	21083850	46	40	46	8	4	4	12	16	10	0	0.103	0.997	1.000
174	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	NFKB1(2), NFKBIA(2), PLCB1(3), PRKCA(2), RELA(6)	8271451	15	15	12	7	2	3	0	2	7	1	0.954	0.997	1.000
175	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARSA(2), GOT1(3), GOT2(2), PAH(5), TAT(2), YARS(1), YARS2(1)	8708104	16	16	16	4	1	1	3	5	6	0	0.672	0.997	1.000
176	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	PLCD1(3), PRKCA(2)	4863301	5	5	5	2	0	1	0	2	2	0	0.866	0.997	1.000
177	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREM(1), FOS(1), JUN(2), MAPK3(3), OPRK1(2), POLR2A(13), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3)	12685957	32	31	31	8	10	2	4	10	6	0	0.264	0.997	1.000
178	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(8), CD38(1), ENPP1(4), ENPP3(2), NADSYN1(1), NMNAT2(2), NNMT(1), NNT(7), NT5M(2), QPRT(1)	14586679	29	28	29	6	2	2	3	17	5	0	0.355	0.997	1.000
179	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(19), CDC25A(1), CDC25B(1), CDC25C(3), CHEK1(1), MYT1(5), WEE1(2)	13884133	32	29	31	7	2	4	4	13	9	0	0.372	0.997	1.000
180	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(8), EIF4E(2), FBL(1), GPT(4), LDHB(2), LDHC(3), MAPK14(1), NCL(5)	8935488	26	24	25	8	0	1	10	7	8	0	0.733	0.998	1.000
181	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	21	AKT1(2), CCNE1(2), CDK2(2), CDK4(6), CDK6(1), CDKN1A(3), CDKN1B(1), E2F1(1), HRAS(1), MAPK3(3), NFKB1(2), NFKBIA(2), PAK1(3), PIK3R1(5), RAF1(4), RB1(4), RELA(6)	18039064	48	40	42	9	4	4	5	12	19	4	0.498	0.998	1.000
182	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	16	ADRB2(2), AKT1(2), ANXA1(1), CALM2(1), GNAS(6), GNB1(3), NFKB1(2), NOS3(3), NPPA(1), NR3C1(4), PIK3R1(5), RELA(6), SYT1(1)	15525528	37	35	34	7	5	7	2	13	9	1	0.330	0.998	1.000
183	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	14	CD8A(1), IL3(1), IL4(1), IL9(1)	5091265	4	4	4	2	0	1	2	0	1	0	0.817	0.998	1.000
184	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(5), ATIC(2), FTCD(2), GART(4), MTFMT(1), MTHFD1(7), MTHFD1L(4), MTHFD2(2), MTHFR(1), SHMT1(2), SHMT2(5), TYMS(1)	19046794	36	35	36	7	3	6	3	18	6	0	0.261	0.998	1.000
185	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	12	AKT1(2), BAD(1), CHRNB1(4), MUSK(4), PIK3R1(5), PTK2(3), PTK2B(3), RAPSN(1), SRC(3), TERT(10)	14173411	36	33	36	9	4	10	2	13	7	0	0.337	0.998	1.000
186	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	14	ACADL(3), ACADM(1), ACADS(3), ACSL1(4), ACSL4(1), CPT1A(2), CPT2(2), EHHADH(6), HADHA(4), PECR(4), SCP2(3)	15357545	33	32	31	8	2	8	7	11	4	1	0.175	0.998	1.000
187	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	LPL(3), NR3C1(4), PPARG(2), RETN(1), TNF(1)	5591626	11	11	11	5	1	2	2	3	3	0	0.812	0.998	1.000
188	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	6	ATM(19), ATR(12), CDC25C(3), CHEK1(1), CHEK2(2)	15303497	37	31	36	9	3	4	4	13	13	0	0.572	0.998	1.000
189	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	28	AADAT(2), AASDH(5), AASDHPPT(3), AASS(8), ACAT1(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(4), ALDH2(4), ALDH3A2(2), BBOX1(1), DOT1L(9), ECHS1(3), EHHADH(6), EHMT1(4), EHMT2(8), HADHA(4), PLOD1(2), PLOD2(5), SHMT1(2), SHMT2(5), TMLHE(1)	32683051	81	74	79	13	8	14	14	28	17	0	0.00925	0.998	1.000
190	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	21	CCNA1(7), CCNB1(1), CCND2(1), CCNE1(2), CCNH(1), CDC25A(1), CDK2(2), CDK4(6), CDK6(1), CDKN1A(3), CDKN1B(1), CDKN2C(1), E2F1(1), RB1(4)	15496110	32	28	26	7	1	2	4	6	16	3	0.547	0.999	1.000
191	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(8), C5(6), C6(3), C7(4), ICAM1(3), ITGA4(3), ITGAL(7), ITGB1(7), ITGB2(2), SELP(2), SELPLG(3), TNF(1), VCAM1(6)	24821920	55	51	55	10	5	7	8	25	10	0	0.103	0.999	1.000
192	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(1), CAT(2), EPX(3), LPO(1), MPO(6), MTHFR(1), PRDX6(2), SHMT1(2), SHMT2(5), TPO(4)	11498705	27	26	27	6	1	3	6	10	7	0	0.379	0.999	1.000
193	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	23	ALDH1A1(1), ALDH1A2(1), ALDH1B1(4), ALDH2(4), ALDH3A2(2), ALDH3B1(4), ALDH3B2(3), AOC2(4), AOC3(2), ASPA(1), CNDP1(4), DDC(3), HAL(1), HARS(1), HDC(1), HNMT(2), MAOA(2), MAOB(2), PRPS1(1), PRPS2(4)	23222751	47	45	46	9	5	9	9	16	8	0	0.0656	0.999	1.000
194	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	ADAM17(2), DLL1(1), FURIN(3), NOTCH1(12)	8454303	18	18	16	5	3	4	0	5	5	1	0.573	0.999	1.000
195	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(2), JAK1(6), JAK2(7), JAK3(4), PIAS1(5), PIAS3(3), PTPRU(4), SOAT1(4)	13744220	35	30	33	8	2	2	8	12	11	0	0.373	0.999	1.000
196	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(3), CAMK1G(3), HDAC9(4), MEF2A(2), MEF2D(1)	8146447	13	13	12	4	2	1	2	3	5	0	0.590	0.999	1.000
197	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	B3GALT1(1), B3GALT2(2), B3GALT5(3), B3GNT5(1), FUT2(2), FUT3(2), ST3GAL3(3), ST3GAL4(2)	6991590	16	15	14	6	5	0	2	3	6	0	0.820	0.999	1.000
198	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	CHST11(1), CHST12(2), PAPSS1(2), PAPSS2(4), SULT1A1(2), SULT1E1(2), SULT2A1(1), SUOX(4)	8895794	18	18	17	6	3	3	4	2	6	0	0.664	0.999	1.000
199	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	10	AHCY(5), BHMT(7), CTH(2), DNMT3B(4), MARS(3), MARS2(4), MAT1A(1), MAT2B(1)	12279257	27	26	27	7	1	5	4	10	7	0	0.505	0.999	1.000
200	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(2), B4GALT1(1), B4GALT3(2), B4GALT5(2), ST3GAL1(2), ST3GAL3(3), ST3GAL4(2)	7686861	14	14	13	7	2	0	2	4	6	0	0.955	0.999	1.000
201	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5E(1), ATP6AP1(4), ATP6V0A1(3), ATP6V0A4(4), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(4), ATP6V1B2(4), ATP6V1D(1), ATP6V1G1(1), SHMT1(2)	15207527	31	29	31	7	2	3	7	12	6	1	0.393	1.000	1.000
202	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5E(1), ATP6AP1(4), ATP6V0A1(3), ATP6V0A4(4), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(4), ATP6V1B2(4), ATP6V1D(1), ATP6V1G1(1), SHMT1(2)	15207527	31	29	31	7	2	3	7	12	6	1	0.393	1.000	1.000
203	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5E(1), ATP6AP1(4), ATP6V0A1(3), ATP6V0A4(4), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(4), ATP6V1B2(4), ATP6V1D(1), ATP6V1G1(1), SHMT1(2)	15207527	31	29	31	7	2	3	7	12	6	1	0.393	1.000	1.000
204	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	35	ACAA1(3), ACADL(3), ACADM(1), ACADS(3), ACADSB(1), ACAT1(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(4), ALDH2(4), ALDH3A2(2), AOX1(8), BCAT1(1), BCKDHA(2), ECHS1(3), EHHADH(6), HADHA(4), HADHB(4), HIBADH(1), HMGCL(2), IVD(2), MCCC1(3), MCCC2(3), MCEE(1), MUT(2), OXCT1(2), PCCA(2), PCCB(3)	35223809	73	71	71	12	5	10	16	27	14	1	0.0233	1.000	1.000
205	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(1), COASY(2), DPYD(5), DPYS(4), ENPP1(4), ENPP3(2), PANK1(2), PANK2(5), PANK3(3), PANK4(1), PPCS(1), UPB1(1)	13783530	31	29	31	8	3	2	3	13	10	0	0.545	1.000	1.000
206	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(1), CYP11A1(2), CYP11B1(4), CYP11B2(2), CYP17A1(3), CYP21A2(2), HSD11B2(1), HSD3B1(1)	9088362	16	15	16	6	1	0	2	8	5	0	0.691	1.000	1.000
207	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(1), CYP11A1(2), CYP11B1(4), CYP11B2(2), CYP17A1(3), CYP21A2(2), HSD11B2(1), HSD3B1(1)	9088362	16	15	16	6	1	0	2	8	5	0	0.691	1.000	1.000
208	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(1), CAPN1(2), CSNK1A1(2), GSK3B(3), MAPT(4), PPP2CA(1)	9382975	13	13	11	8	0	1	2	2	8	0	0.987	1.000	1.000
209	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	19	AKT1(2), EIF4A1(1), EIF4A2(4), EIF4B(5), EIF4E(2), EIF4EBP1(1), EIF4G1(7), EIF4G2(4), EIF4G3(7), MKNK1(2), PDK2(3), PIK3R1(5), PPP2CA(1), RPS6KB1(2), TSC1(5), TSC2(12)	24719664	63	57	61	11	6	10	7	20	17	3	0.0863	1.000	1.000
210	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(2), CREM(1), FHL5(3), FSHR(2), GNAS(6), XPO1(7)	9349842	21	21	21	5	5	1	4	7	4	0	0.518	1.000	1.000
211	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	14	ADH1A(2), ADH1B(2), ADH4(2), ADH5(1), ADH6(2), ADHFE1(3), ALDH1B1(4), ALDH2(4), ALDH3A2(2), ALDH7A1(1)	12371978	23	23	22	7	2	2	3	11	5	0	0.659	1.000	1.000
212	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(5), CTH(2), GGT1(4), MARS(3), MARS2(4), MAT1A(1), MAT2B(1), PAPSS1(2), PAPSS2(4), SCLY(3), SEPHS1(1)	12160401	30	29	30	9	3	5	7	7	8	0	0.501	1.000	1.000
213	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(1), CDC25A(1), CDC25B(1), CDC25C(3), CSK(4), GRB2(2), PRKCA(2), PTPRA(5), SRC(3)	9194770	22	20	22	6	0	7	4	8	3	0	0.420	1.000	1.000
214	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(3), GBA(3), LPO(1), MPO(6), PRDX6(2), TPO(4)	8274972	19	18	19	5	1	2	5	6	5	0	0.459	1.000	1.000
215	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	LDLR(3), NR1H3(2), NR1H4(2)	5216943	7	7	7	4	0	2	0	3	2	0	0.851	1.000	1.000
216	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA2A(5), ADORA2B(1), ADORA3(2), P2RY1(3), P2RY2(2), P2RY6(2)	5565472	15	14	15	6	3	2	2	7	1	0	0.580	1.000	1.000
217	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(1), SRP68(2), SRP72(3), SRP9(1), SRPR(1)	7594500	8	7	8	3	1	2	1	3	1	0	0.673	1.000	1.000
218	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CCL2(1), IL1B(1), MST1R(1), TNF(1)	6032580	4	4	4	2	0	1	0	1	2	0	0.944	1.000	1.000
219	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(6), CARS2(3), CTH(2), GOT1(3), GOT2(2), LDHAL6B(1), LDHB(2), LDHC(3), MPST(2), SULT1B1(2), SULT1C2(1), SULT1C4(3), SULT4A1(1)	12512961	31	31	29	8	2	1	5	11	12	0	0.760	1.000	1.000
220	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(1), AOC2(4), AOC3(2), CES1(8), DDHD1(2), ESCO1(2), ESCO2(1), LIPA(1), PLA1A(3), PNPLA3(3), PRDX6(2), SH3GLB1(3)	25070993	32	30	30	3	1	4	4	9	14	0	0.0818	1.000	1.000
221	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	28	ATF1(2), BAD(1), BRAF(4), CREB5(3), DUSP4(1), DUSP6(2), DUSP9(2), EEF2K(4), EIF4E(2), GRB2(2), MAP2K2(1), MAP3K8(1), MAPK3(3), MKNK1(2), MKNK2(1), MOS(1), NFKB1(2), RAP1A(1), RPS6KA3(3), SHC1(4), SOS1(8), SOS2(7), TRAF3(1)	28001669	58	55	58	10	5	11	12	19	10	1	0.0416	1.000	1.000
222	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(1), CAT(2), EPX(3), LPO(1), MPO(6), PRDX1(1), PRDX5(1), PRDX6(2), SHMT1(2), SHMT2(5), TPO(4)	11705473	28	27	28	7	1	3	7	10	7	0	0.462	1.000	1.000
223	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	19	ACO1(5), CS(2), DLD(4), FH(2), IDH1(2), IDH3B(2), IDH3G(2), MDH1(2), MDH2(1), PC(8), PCK1(5), SDHA(9), SDHB(1), SUCLA2(2), SUCLG1(6), SUCLG2(2)	19750415	55	51	55	13	3	8	7	21	14	2	0.276	1.000	1.000
224	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	12	CNR1(1), CNR2(3), MTNR1B(1), PTAFR(1), PTGDR(1), PTGER2(1), PTGER4(1), PTGFR(5), PTGIR(2), TBXA2R(4)	7363229	20	19	20	9	3	3	2	8	4	0	0.790	1.000	1.000
225	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(3), GABRA2(1), GABRA3(1), GABRA4(1), GABRA5(1), GABRA6(1), PRKCE(4)	7712784	12	12	12	8	0	0	3	6	3	0	0.983	1.000	1.000
226	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(3), ALOX15B(3), ALOX5(4), DPEP1(1), GGT1(4), LTA4H(4), PLA2G6(4), PTGDS(1), PTGS1(2), PTGS2(5), TBXAS1(4)	15047940	35	32	33	9	4	5	8	8	9	1	0.357	1.000	1.000
227	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(2), PLCG1(4), PRKCA(2), PTK2B(3)	6689394	11	11	10	6	1	3	1	2	4	0	0.932	1.000	1.000
228	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP5E(1), ATP6AP1(4), ATP6V0A1(3), ATP6V0A4(4), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(4), ATP6V1B2(4), ATP6V1D(1), ATP6V1G1(1), FDXR(2), SHMT1(2)	16061007	33	31	33	8	2	3	7	14	6	1	0.438	1.000	1.000
229	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(3), CLOCK(4), CRY1(1), CSNK1E(3), PER1(5)	8447097	16	16	15	5	2	1	4	4	5	0	0.693	1.000	1.000
230	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(1), PSMA3(2), PSMA4(2), PSMA6(3), PSMA7(1), PSMB1(2), PSMB10(1), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(1)	8538360	16	16	16	5	1	1	1	8	5	0	0.834	1.000	1.000
231	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	13	AKT1(2), BAD(1), CASP9(2), CHUK(2), GHR(1), NFKB1(2), NFKBIA(2), PIK3R1(5), PPP2CA(1), RELA(6)	12011022	24	24	21	6	2	5	1	7	8	1	0.575	1.000	1.000
232	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), HS3ST2(2), HS3ST3A1(1), XYLT1(5), XYLT2(2)	6037936	11	11	11	7	3	3	0	3	2	0	0.806	1.000	1.000
233	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), HS3ST2(2), HS3ST3A1(1), XYLT1(5), XYLT2(2)	6037936	11	11	11	7	3	3	0	3	2	0	0.806	1.000	1.000
234	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(2), GRB2(2), IL4(1), IL4R(4), IRS1(5), JAK1(6), JAK3(4), RPS6KB1(2), SHC1(4), STAT6(5)	14280336	35	33	35	9	6	3	5	12	9	0	0.428	1.000	1.000
235	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	15	AHCY(5), AMD1(2), BHMT(7), CTH(2), DNMT3B(4), MARS(3), MARS2(4), MAT1A(1), MAT2B(1), MTAP(2), MTFMT(1), TAT(2)	15637296	34	33	34	9	3	6	6	12	7	0	0.449	1.000	1.000
236	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	11	ACTR2(2), ARPC1B(1), CDC42(1), PAK1(3), PDGFRA(6), PIK3R1(5)	9708445	18	18	18	7	2	3	1	7	5	0	0.925	1.000	1.000
237	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(8), CD44(3), IL1B(1), IL6R(2), SELL(2), SPN(1), TGFB2(2), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TNFSF8(1)	13133143	23	22	21	5	2	7	3	3	8	0	0.316	1.000	1.000
238	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	B3GNT1(2), B3GNT2(3), B3GNT3(1), B3GNT5(1), B4GALT1(1), B4GALT3(2), B4GALT4(2), FUT2(2), FUT3(2), FUT4(2), FUT6(4), FUT7(1), GCNT2(3), ST8SIA1(2)	15127214	28	26	27	6	6	4	4	9	5	0	0.249	1.000	1.000
239	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	ADAM17(2), APC(9), AXIN1(4), BTRC(2), CTNNB1(2), DLL1(1), DVL1(1), FZD1(3), GSK3B(3), NOTCH1(12), WNT1(2)	20334446	41	39	38	9	5	6	3	16	10	1	0.342	1.000	1.000
240	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	43	ABAT(1), ACAA1(3), ACADM(1), ACADS(3), ACAT1(1), ALDH1B1(4), ALDH2(4), ALDH3A2(2), ALDH7A1(1), AOX1(8), BCAT1(1), BCKDHA(2), DBT(2), DLD(4), ECHS1(3), EHHADH(6), HADH(1), HADHA(4), HADHB(4), HIBADH(1), HIBCH(1), HMGCL(2), HMGCS1(2), HMGCS2(1), HSD17B4(1), IVD(2), MCCC1(3), MCCC2(3), MCEE(1), MUT(2), OXCT1(2), PCCA(2), PCCB(3)	42410540	81	78	79	12	6	9	21	29	15	1	0.00664	1.000	1.000
241	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(3), ELK1(1), EPOR(3), FOS(1), GRB2(2), HRAS(1), JAK2(7), JUN(2), MAPK3(3), PLCG1(4), PTPN6(3), RAF1(4), SHC1(4), SOS1(8), STAT5A(3), STAT5B(3)	21357045	52	49	50	10	4	6	10	18	14	0	0.208	1.000	1.000
242	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(3), BIRC2(2), BIRC3(5), CASP10(3), CASP7(1), CASP8(1), CASP9(2), DFFA(1), DFFB(1), PRF1(1), SCAP(4), SREBF1(4), SREBF2(8)	17987606	36	35	36	8	1	7	6	11	11	0	0.317	1.000	1.000
243	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(4), AGT(4), AGTR2(1), EDNRB(3), EGF(5), EGFR(9), FOS(1), HRAS(1), JUN(2), MYC(1), NFKB1(2), PLCG1(4), PRKCA(2), RELA(6)	20353047	45	39	39	9	5	5	4	17	13	1	0.383	1.000	1.000
244	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(2), ADRB2(2), GNAS(6), PLCE1(6), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), RAP2B(2)	14475925	28	28	28	7	4	3	3	10	8	0	0.496	1.000	1.000
245	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(2), IFNA1(1), IFNB1(2), IKBKB(3), IL1B(1), IL1R1(3), IL1RAP(4), IL1RN(1), IRAK1(3), IRAK3(4), JUN(2), MAP2K3(3), MAP3K1(7), MAP3K7(3), MAPK14(1), NFKB1(2), NFKBIA(2), RELA(6), TGFB2(2), TNF(1), TRAF6(2)	29600469	55	49	51	9	7	12	1	17	16	2	0.112	1.000	1.000
246	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(3), PARK2(2), SNCAIP(4), UBE2E2(1), UBE2L3(1)	6336035	11	11	11	5	1	4	1	3	2	0	0.749	1.000	1.000
247	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM2(1), CAMK1(3), CAMK1G(3), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(3), ESRRA(1), HDAC5(3), MEF2A(2), MEF2D(1), PPP3CA(3), PPP3CC(3), SLC2A4(2), SYT1(1)	20534709	31	31	30	5	4	2	4	11	10	0	0.181	1.000	1.000
248	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(3), ARHGAP5(6), ARHGDIB(1), CASP1(3), CASP10(3), CASP8(1), CASP9(2), JUN(2), PRF1(1)	12699345	22	21	22	6	0	4	2	8	8	0	0.737	1.000	1.000
249	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(9), CDH1(2), CREBBP(9), EP300(16), MAP3K7(3), MAPK3(3), SKIL(2), TGFB2(2), TGFBR1(1), TGFBR2(2)	25692930	49	45	46	9	3	5	10	16	14	1	0.109	1.000	1.000
250	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(2), ADRB2(2), CFTR(8), GNAS(6), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), SLC9A3R1(1)	12776536	29	29	29	8	4	2	1	14	8	0	0.655	1.000	1.000
251	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(4), CYP2A13(5), CYP2A6(4), CYP2A7(2), NAT1(1), NAT2(1), XDH(6)	7901121	23	22	23	8	4	3	3	9	4	0	0.713	1.000	1.000
252	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	24	ABAT(1), ACADM(1), ALDH1B1(4), ALDH2(4), ALDH3A2(2), ALDH7A1(1), AOC2(4), AOC3(2), CNDP1(4), DPYD(5), DPYS(4), ECHS1(3), EHHADH(6), GAD1(2), GAD2(2), HADHA(4), HIBCH(1), MLYCD(3), SMS(2), UPB1(1)	25685376	56	54	55	12	3	7	15	15	15	1	0.113	1.000	1.000
253	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(1), FUCA1(2), FUCA2(1), GLB1(5), HEXA(4), LCT(7), MAN2C1(5), MANBA(2), NEU1(1)	16037207	28	27	28	7	3	4	3	13	5	0	0.432	1.000	1.000
254	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	28	DPM2(1), EGFR(9), ELK1(1), GNAS(6), GNB1(3), GRB2(2), HRAS(1), IGF1R(3), ITGB1(7), MAP2K2(1), MAPK3(3), MKNK1(2), MKNK2(1), MYC(1), NGFR(1), PDGFRA(6), PPP2CA(1), PTPRR(4), RAF1(4), RPS6KA5(2), SHC1(4), SOS1(8), SRC(3), STAT3(3)	31290010	77	66	75	15	8	13	7	31	18	0	0.139	1.000	1.000
255	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	18	EXT1(3), EXT2(1), EXTL1(1), EXTL3(3), GLCE(4), HS2ST1(2), HS3ST2(2), HS3ST3A1(1), HS3ST5(1), HS6ST1(3), HS6ST2(3), HS6ST3(1), NDST1(2), NDST2(4), NDST3(1), NDST4(7)	19663279	39	36	38	8	5	4	4	14	12	0	0.288	1.000	1.000
256	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	19	CSNK2A1(3), ELK1(1), FOS(1), GRB2(2), HRAS(1), INS(1), IRS1(5), JUN(2), MAPK3(3), PIK3R1(5), PTPN11(2), RAF1(4), RASA1(7), SHC1(4), SLC2A4(2), SOS1(8)	20023235	51	49	51	11	8	11	4	18	10	0	0.199	1.000	1.000
257	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(1), ST3GAL1(2), ST3GAL4(2), ST3GAL5(1), ST6GALNAC2(3), ST8SIA1(2)	5420228	11	11	11	5	1	2	1	6	1	0	0.712	1.000	1.000
258	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(1), ALDH4A1(2), CAD(12), CPS1(5), EPRS(4), GAD1(2), GAD2(2), GCLC(4), GFPT1(2), GLS(6), GLS2(4), GLUL(2), GMPS(1), GOT1(3), GOT2(2), GPT(4), GPT2(2), GSS(1), NADSYN1(1), PPAT(3), QARS(1)	33229940	64	57	60	10	5	8	12	21	17	1	0.0729	1.000	1.000
259	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	13	CHUK(2), IKBKAP(2), IKBKB(3), MAP3K1(7), NFKB1(2), NFKBIA(2), RELA(6), TNFAIP3(2), TRAF3(1), TRAF6(2)	18573647	29	27	26	5	2	7	0	7	12	1	0.317	1.000	1.000
260	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(4), POLB(2), POLD1(7), POLD3(1), POLE(5), POLE2(1), POLG(6), POLG2(5), POLH(4), POLI(3), POLK(5), POLL(2), POLM(4), POLQ(14), PRIM1(3), PRIM2(4), REV1(5), REV3L(15), RFC5(3)	41235141	93	79	87	15	5	8	6	44	30	0	0.143	1.000	1.000
261	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(2), MAPK14(1), NFKB1(2), RELA(6), TNFRSF13B(1), TNFSF13(1), TRAF2(1), TRAF3(1), TRAF5(5), TRAF6(2)	14523652	22	21	19	5	0	5	0	7	9	1	0.656	1.000	1.000
262	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(2), EIF2AK4(6), EIF2B5(2), EIF2S2(2), EIF2S3(2), EIF5(3), GSK3B(3), PPP1CA(1)	11555478	21	20	19	8	1	1	5	6	8	0	0.851	1.000	1.000
263	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(3), GNAS(6), GNB1(3), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PRKCA(2)	9484817	24	23	24	7	4	3	0	12	5	0	0.643	1.000	1.000
264	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(1), APAF1(3), CASP9(2), DAXX(6), FAS(2), FASLG(2), HSPB2(2), MAPKAPK2(1), TNF(1)	10996543	20	18	20	5	2	5	1	7	5	0	0.496	1.000	1.000
265	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	ASAH1(2), BFAR(1), BRAF(4), CAMP(1), CREB5(3), RAF1(4), SNX13(3), SRC(3)	11545453	21	17	21	6	1	4	4	8	3	1	0.563	1.000	1.000
266	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(3), ABAT(1), ADSL(3), AGXT(2), AGXT2(1), ASL(4), ASNS(2), ASPA(1), CAD(12), CRAT(3), DARS(3), DDO(1), GAD1(2), GAD2(2), GOT1(3), GOT2(2), GPT(4), GPT2(2), PC(8)	25927610	59	52	55	11	2	7	11	13	25	1	0.265	1.000	1.000
267	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(1), B4GALNT1(2), GLB1(5), HEXA(4), LCT(7), SLC33A1(2), ST3GAL1(2), ST3GAL5(1), ST6GALNAC3(3), ST6GALNAC5(4), ST6GALNAC6(1), ST8SIA1(2), ST8SIA5(1)	16040691	35	32	35	9	4	6	2	14	9	0	0.361	1.000	1.000
268	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	30	ABAT(1), ACACA(9), ACADL(3), ACADM(1), ACADSB(1), ACAT1(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(4), ALDH2(4), ALDH3A2(2), ECHS1(3), EHHADH(6), HADHA(4), LDHB(2), LDHC(3), MCEE(1), MLYCD(3), MUT(2), PCCA(2), PCCB(3), SUCLA2(2), SUCLG1(6), SUCLG2(2)	32273349	67	64	65	13	4	9	17	21	14	2	0.0565	1.000	1.000
269	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	29	CS(2), DLAT(2), DLD(4), FH(2), IDH3B(2), IDH3G(2), MDH1(2), MDH2(1), OGDH(8), PC(8), PDHA1(1), PDHA2(3), PDHB(1), PDHX(2), PDK1(1), PDK2(3), PDK3(2), PDK4(1), PDP2(2), SDHA(9), SDHB(1), SDHD(2), SUCLA2(2), SUCLG1(6), SUCLG2(2)	27593149	71	63	71	16	3	13	9	25	19	2	0.174	1.000	1.000
270	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(2), B3GNT2(3), B3GNT7(1), B4GALT1(1), B4GALT3(2), B4GALT4(2), CHST1(2), CHST2(2), CHST4(1), CHST6(2), ST3GAL1(2), ST3GAL3(3), ST3GAL4(2)	11591238	25	24	24	8	4	4	2	6	9	0	0.672	1.000	1.000
271	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CHPT1(3), LCMT1(1), LCMT2(4), METTL2B(1), PCYT1A(1), PRMT2(2), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(2), PRMT8(3)	13882855	24	22	24	6	1	2	4	8	9	0	0.611	1.000	1.000
272	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(1), PSMA3(2), PSMA4(2), PSMA6(3), PSMA7(1), PSMB1(2), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(1), RPN1(3), RPN2(1), UBE2A(2), UBE3A(2)	13232474	23	23	23	7	1	2	2	11	7	0	0.782	1.000	1.000
273	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	14	AKT1(2), BCAR1(6), CDKN1B(1), GRB2(2), ILK(4), ITGB1(7), MAPK3(3), PDK2(3), PIK3R1(5), PTK2(3), SHC1(4), SOS1(8)	16160917	48	41	46	12	4	7	4	15	17	1	0.615	1.000	1.000
274	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(3), BAD(1), BAK1(1), BCL10(1), BCL2L11(1), BID(2), CASP9(2), CES1(8)	11444024	19	19	17	5	1	2	3	6	7	0	0.613	1.000	1.000
275	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(1), FUCA1(2), FUCA2(1), GLB1(5), HEXA(4), LCT(7), MAN2B1(1), MAN2B2(2), MAN2C1(5), MANBA(2), NEU1(1)	19751506	31	29	31	7	4	4	4	14	5	0	0.299	1.000	1.000
276	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	12	FOS(1), JUN(2), KEAP1(3), MAPK14(1), PRKCA(2)	7538032	9	9	9	8	1	1	2	3	2	0	0.989	1.000	1.000
277	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(10), APOBEC1(2), APOBEC3B(1), APOBEC3G(1), APOBEC4(1)	7316523	15	14	15	8	3	0	5	6	1	0	0.913	1.000	1.000
278	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	11	DPM2(1), HRAS(1), MAP2K2(1), MAPK3(3), NGFR(1), RAF1(4)	7021019	11	11	11	5	1	1	2	6	1	0	0.878	1.000	1.000
279	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	32	AARS(3), AARS2(3), ABAT(1), ACY3(2), ADSL(3), ADSSL1(2), AGXT(2), AGXT2(1), ASL(4), ASNS(2), ASPA(1), ASS1(3), CAD(12), CRAT(3), DARS(3), DARS2(1), DDO(1), DLAT(2), DLD(4), GAD1(2), GAD2(2), GOT1(3), GOT2(2), GPT(4), GPT2(2), NARS2(6), PC(8), PDHA1(1), PDHA2(3), PDHB(1)	37075490	87	72	83	15	5	10	15	24	31	2	0.0759	1.000	1.000
280	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	30	ANPEP(8), G6PD(2), GCLC(4), GGT1(4), GSS(1), GSTA1(1), GSTA2(1), GSTA3(1), GSTA4(1), GSTM1(2), GSTM2(1), GSTM4(1), GSTM5(1), GSTP1(2), GSTT1(2), IDH1(2)	17455311	34	30	34	9	3	3	10	11	7	0	0.426	1.000	1.000
281	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(6), KHK(6), LCT(7), MPI(1), PGM1(1), PYGL(2), PYGM(4), TPI1(2)	13537100	29	28	29	9	8	1	5	11	4	0	0.470	1.000	1.000
282	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	DAB1(5), FYN(2), LRP8(4), RELN(7), VLDLR(4)	14040613	22	21	17	6	2	4	0	5	11	0	0.891	1.000	1.000
283	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(2), FOS(1), HRAS(1), JUN(2), MAPK3(3), MYC(1), NFKB1(2), NFKBIA(2), PLCB1(3), PRKCA(2), RAF1(4), RELA(6), TNF(1)	15171285	30	29	27	9	6	3	2	8	10	1	0.737	1.000	1.000
284	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	11	DHRS2(1), ESCO1(2), ESCO2(1), PNPLA3(3), SH3GLB1(3)	15818456	10	10	10	2	0	2	2	3	3	0	0.544	1.000	1.000
285	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	14	CCR5(1), CD2(2), CD3E(1), CD3G(2), IL12RB1(4), IL12RB2(2), JAK2(7), STAT4(2), TYK2(7)	13853267	28	28	27	8	3	0	6	11	8	0	0.755	1.000	1.000
286	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	14	AKT1(2), EGFR(9), IGF1R(3), MYC(1), POLR2A(13), PPP2CA(1), PRKCA(2), RB1(4), TEP1(9), TERF1(2), TERT(10), TNKS(6), XRCC5(4)	27088863	66	55	63	15	11	12	5	20	16	2	0.138	1.000	1.000
287	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(5), GNA12(1), PRKACB(2), PRKACG(2), PRKAG1(5), PRKAR2A(1), PRKAR2B(3)	10017406	19	19	19	6	3	2	3	7	4	0	0.616	1.000	1.000
288	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(2), CALCR(3), CALCRL(2), CD97(6), CRHR1(2), CRHR2(3), ELTD1(4), EMR1(2), EMR2(4), GIPR(2), GLP1R(3), GLP2R(3), GPR64(2), LPHN1(5), LPHN2(4), LPHN3(9), SCTR(1), VIPR1(1), VIPR2(2)	27394928	60	52	59	13	11	7	10	21	11	0	0.133	1.000	1.000
289	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	FUT2(2), GBGT1(2), GLA(1), HEXA(4), ST3GAL1(2), ST3GAL4(2), ST8SIA1(2)	9864830	15	15	15	6	1	2	1	8	3	0	0.704	1.000	1.000
290	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(2), HK1(6), IMPA1(1), PGM1(1)	10177273	10	9	10	6	3	0	0	4	3	0	0.895	1.000	1.000
291	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	15	B3GAT1(2), B3GAT2(1), B3GAT3(1), CHPF(1), CHST11(1), CHST12(2), CHST14(1), CHST3(2), CHST7(2), DSE(1), UST(1), XYLT1(5), XYLT2(2)	11335976	22	22	22	9	5	6	0	6	5	0	0.637	1.000	1.000
292	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	20	AKT1(2), BAD(1), CASP9(2), CDC42(1), CHUK(2), ELK1(1), HRAS(1), MAPK3(3), NFKB1(2), PIK3R1(5), RAF1(4), RALA(2), RALBP1(2), RELA(6)	16990469	34	33	30	8	2	6	3	11	11	1	0.596	1.000	1.000
293	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	20	ADCY1(2), CD3E(1), CD3G(2), CREBBP(9), CSK(4), GNAS(6), GNB1(3), HLA-DRA(1), HLA-DRB1(6), LCK(1), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PTPRC(8), ZAP70(1)	21399940	54	49	54	12	6	6	5	24	13	0	0.275	1.000	1.000
294	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	20	ADCY1(2), CD3E(1), CD3G(2), CREBBP(9), CSK(4), GNAS(6), GNB1(3), HLA-DRA(1), HLA-DRB1(6), LCK(1), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PTPRC(8), ZAP70(1)	21399940	54	49	54	12	6	6	5	24	13	0	0.275	1.000	1.000
295	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	17	AKT1(2), EIF2B5(2), EIF2S2(2), EIF2S3(2), EIF4E(2), EIF4EBP1(1), GSK3B(3), IGF1R(3), INPPL1(4), PDK2(3), PIK3R1(5), PPP2CA(1), RPS6KB1(2)	16706000	32	30	30	9	4	4	2	10	12	0	0.594	1.000	1.000
296	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	26	ACLY(8), ACO1(5), CLYBL(3), CS(2), DLD(4), FH(2), IDH1(2), IDH3B(2), IDH3G(2), MDH1(2), MDH2(1), OGDH(8), OGDHL(2), PC(8), PCK1(5), PCK2(2), SDHA(9), SDHB(1), SDHD(2), SUCLA2(2), SUCLG1(6), SUCLG2(2)	28986201	80	70	80	19	5	13	8	31	21	2	0.241	1.000	1.000
297	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	15	ARSB(1), GALNS(6), GLB1(5), GNS(4), GUSB(5), HEXA(4), HGSNAT(3), HPSE(2), HPSE2(4), HYAL1(2), HYAL2(1), IDS(2), LCT(7), NAGLU(2)	18761677	48	41	48	12	6	7	6	17	12	0	0.272	1.000	1.000
298	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	17	DHRS2(1), LCMT1(1), LCMT2(4), METTL2B(1), PRMT2(2), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(2), PRMT8(3)	14109858	21	19	21	5	1	2	5	6	7	0	0.481	1.000	1.000
299	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	25	AKT1(2), AKT2(5), AKT3(3), BAD(1), GRB2(2), GSK3A(2), GSK3B(3), IL4R(4), IRS1(5), JAK1(6), JAK3(4), MAP4K1(4), MAPK3(3), PDK1(1), PIK3CD(2), PIK3R1(5), PPP1R13B(4), RAF1(4), SHC1(4), SOS1(8), SOS2(7), STAT6(5)	32874411	84	72	82	17	12	11	17	26	18	0	0.0625	1.000	1.000
300	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(9), ACACB(5), FASN(9), MCAT(2), OLAH(2), OXSM(3)	15626713	30	30	30	9	3	7	5	10	5	0	0.394	1.000	1.000
301	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNA1(1), IFNB1(2), IL15(1), IL16(5), IL3(1), IL4(1), IL9(1), LTA(1), TNF(1)	9777111	14	14	14	7	0	5	2	5	2	0	0.871	1.000	1.000
302	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACOT11(1), ALDH1B1(4), ALDH2(4), ALDH3A2(2), ALDH7A1(1), CYP2C19(1), CYP2C9(1), DHRS2(1), ECHS1(3), EHHADH(6), ESCO1(2), ESCO2(1), HADHA(4), PNPLA3(3), SH3GLB1(3), YOD1(2)	29167374	39	38	38	7	2	7	8	11	11	0	0.128	1.000	1.000
303	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(9), AXIN1(4), BTRC(2), CREBBP(9), CSNK1A1(2), CSNK2A1(3), CTBP1(2), CTNNB1(2), DVL1(1), FZD1(3), GSK3B(3), HDAC1(2), MAP3K7(3), MYC(1), NLK(1), PPARD(1), PPP2CA(1), TLE1(6), WIF1(5), WNT1(2)	29096292	62	54	56	13	6	5	7	20	23	1	0.239	1.000	1.000
304	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	11	AKT1(2), CAT(2), GHR(1), HRAS(1), IGF1R(3), PIK3R1(5), SHC1(4)	10825227	18	16	18	9	3	2	1	8	4	0	0.957	1.000	1.000
305	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	31	ADH1A(2), ADH1B(2), ADH4(2), ADH6(2), ADHFE1(3), ALDH3B1(4), ALDH3B2(3), AOC2(4), AOC3(2), AOX1(8), DBH(2), DCT(4), DDC(3), FAH(1), GOT1(3), GOT2(2), HGD(3), HPD(2), MAOA(2), MAOB(2), TAT(2), TH(4), TPO(4), TYR(5)	30366538	71	65	69	17	11	6	8	26	20	0	0.311	1.000	1.000
306	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	22	ACAT1(1), ACOT11(1), DHRS2(1), ECHS1(3), EHHADH(6), ESCO1(2), ESCO2(1), FN3K(1), HADHA(4), PNPLA3(3), SH3GLB1(3), YOD1(2)	24267951	28	28	27	5	1	5	5	8	9	0	0.274	1.000	1.000
307	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(8), ATP5E(1), ATP6AP1(4), ATP6V0A1(3), ATP6V0A4(4), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(4), ATP6V1B2(4), ATP6V1D(1), ATP6V1G1(1), ATP7A(5), ATP7B(7), COX10(5), COX5A(1), COX7A1(2), COX8A(1), NDUFA1(1), NDUFA10(1), NDUFA11(2), NDUFB2(2), NDUFB4(1), NDUFB5(3), NDUFB6(1), NDUFB7(1), NDUFS1(8), NDUFS2(1), NDUFV1(2), NDUFV2(1), PPA2(2), SDHA(9), SDHB(1), SHMT1(2), UQCRC1(1), UQCRFS1(2)	38390393	99	89	97	21	7	15	18	38	20	1	0.0948	1.000	1.000
308	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	28	HLA-DRA(1), HLA-DRB1(6), IFNA1(1), IFNB1(2), IL15(1), IL3(1), IL4(1), LTA(1), TGFB2(2), TNF(1)	12046466	17	16	17	6	0	5	3	5	4	0	0.739	1.000	1.000
309	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(2), HK1(6), IMPA1(1), IMPA2(3), PGM1(1)	11508127	13	12	13	7	4	0	0	5	4	0	0.901	1.000	1.000
310	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(9), AXIN1(4), CREBBP(9), CTNNB1(2), DVL1(1), EP300(16), FZD1(3), GSK3B(3), HDAC1(2), LDB1(2), LEF1(3), PITX2(2), TRRAP(12), WNT1(2)	32696619	70	61	61	14	5	4	10	27	24	0	0.252	1.000	1.000
311	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	CAD(12), CANT1(1), DCK(1), DCTD(1), DPYD(5), DPYS(4), DTYMK(1), ENTPD1(1), NT5M(2), POLB(2), POLD1(7), POLE(5), POLG(6), POLL(2), POLQ(14), POLR1B(4), POLR2A(13), POLR2B(7), POLR2F(4), POLR2I(1), POLR2J(1), POLRMT(5), RRM1(2), RRM2(1), TK1(1), TK2(2), TXNRD1(2), TYMS(1), UCK1(1), UCK2(1), UMPS(1), UNG(1), UPB1(1), UPP1(2)	57025029	115	93	106	19	9	14	16	32	42	2	0.0311	1.000	1.000
312	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	21	ALDH3B1(4), ALDH3B2(3), AOC2(4), AOC3(2), DDC(3), EPX(3), GOT1(3), GOT2(2), HPD(2), LPO(1), MAOA(2), MAOB(2), MPO(6), PRDX1(1), PRDX5(1), PRDX6(2), TAT(2), TPO(4)	20698523	47	43	46	11	7	5	11	12	12	0	0.224	1.000	1.000
313	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	20	ALG3(3), ALG5(2), B4GALT1(1), B4GALT3(2), B4GALT5(2), DPM1(1), MAN1A1(2), MAN1B1(1), MGAT2(1), MGAT3(1), MGAT4A(3), MGAT4B(1), MGAT5(4), RPN1(3), RPN2(1), ST6GAL1(1)	18566422	29	28	29	8	2	6	1	10	10	0	0.534	1.000	1.000
314	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	25	CSNK2A1(3), EGF(5), EGFR(9), ELK1(1), FOS(1), GRB2(2), HRAS(1), JAK1(6), JUN(2), MAP3K1(7), MAPK3(3), PIK3R1(5), PLCG1(4), PRKCA(2), RAF1(4), RASA1(7), SHC1(4), SOS1(8), STAT1(5), STAT3(3), STAT5A(3)	35212701	85	75	81	17	10	13	7	26	29	0	0.264	1.000	1.000
315	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(1), CYB5R3(2), GCK(2), GFPT1(2), GNE(1), GNPDA1(1), HEXA(4), HK1(6), RENBP(4)	16947245	23	22	23	6	3	0	2	10	8	0	0.597	1.000	1.000
316	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(3), ALDH18A1(2), ARG1(1), ARG2(1), ASL(4), CKB(1), CKMT1B(1), CPS1(5), GATM(1), NAGS(1), OAT(2), ODC1(2), OTC(1), PYCR1(1), SMS(2)	17506301	28	28	28	8	0	2	5	12	9	0	0.784	1.000	1.000
317	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(3), DCXR(1), GUSB(5), RPE(2), UGDH(1), UGP2(1), UGT1A1(5), UGT1A3(1), UGT1A4(2), UGT1A5(2), UGT1A6(3), UGT1A7(3), UGT1A9(5), UGT2A1(3), UGT2A3(3), UGT2B11(2), UGT2B15(1), UGT2B17(1), UGT2B28(5), UGT2B4(4), UGT2B7(6), XYLB(2)	27074632	61	56	61	14	5	7	14	18	17	0	0.309	1.000	1.000
318	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	27	CCL3(1), CCR2(2), CCR3(2), CCR5(1), CCR7(1), CD28(1), CXCR4(1), IFNGR1(3), IFNGR2(2), IL12RB1(4), IL12RB2(2), IL18R1(1), IL4(1), IL4R(4), TGFB2(2)	19119987	28	26	28	8	5	1	4	10	8	0	0.532	1.000	1.000
319	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	16	ACTA1(1), ACTR2(2), ARPC1B(1), NCK1(1), NCKAP1(2), NTRK1(7), PIR(1), PSMA7(1), WASF1(1), WASF2(2), WASF3(2)	13577222	21	21	20	9	0	4	1	11	5	0	0.907	1.000	1.000
320	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	19	APAF1(3), BAK1(1), BID(2), BIK(1), BIRC2(2), BIRC3(5), CASP7(1), CASP8(1), CASP9(2), DFFA(1), DFFB(1), DIABLO(1)	13557694	21	21	21	7	1	4	4	7	5	0	0.628	1.000	1.000
321	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(2), ACOX3(5), FADS2(2), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(4)	10376815	18	18	18	8	3	4	2	7	2	0	0.704	1.000	1.000
322	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	16	CHUK(2), CREBBP(9), EP300(16), IKBKB(3), NFKB1(2), NFKBIA(2), RELA(6), RIPK1(1), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TRADD(2), TRAF6(2)	22330282	48	43	42	11	3	7	7	10	20	1	0.422	1.000	1.000
323	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	32	ABAT(1), ACACA(9), ACACB(5), ACADM(1), ACAT1(1), ACSS1(3), ACSS2(7), ALDH1B1(4), ALDH2(4), ALDH3A2(2), ALDH7A1(1), ECHS1(3), EHHADH(6), HADHA(4), HIBCH(1), LDHAL6B(1), LDHB(2), LDHC(3), MCEE(1), MLYCD(3), MUT(2), PCCA(2), PCCB(3), SUCLA2(2), SUCLG1(6), SUCLG2(2)	38855188	79	70	76	16	4	10	22	21	20	2	0.0747	1.000	1.000
324	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	26	ABAT(1), ACADS(3), ACAT1(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(4), ALDH2(4), ALDH3A2(2), ECHS1(3), EHHADH(6), GAD1(2), GAD2(2), HADHA(4), HMGCL(2), L2HGDH(1), OXCT1(2), PDHA1(1), PDHA2(3), PDHB(1), SDHB(1)	24801031	45	44	43	10	6	8	10	13	8	0	0.122	1.000	1.000
325	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(2), IL4(1), JUNB(2), MAF(2), MAP2K3(3), MAPK14(1), NFATC1(4), NFATC2(8), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3)	11365863	33	31	31	11	7	0	2	14	10	0	0.732	1.000	1.000
326	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	40	AKT1(2), AKT2(5), AKT3(3), BRAF(4), DDIT4(1), EIF4B(5), EIF4EBP1(1), FIGF(1), HIF1A(4), INS(1), MAPK3(3), PGF(2), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PRKAA1(1), RICTOR(7), RPS6KA3(3), RPS6KA6(1), RPS6KB1(2), RPS6KB2(2), STK11(2), TSC1(5), TSC2(12), ULK1(2), ULK2(3), ULK3(3), VEGFA(1), VEGFC(2)	47733502	101	95	98	19	11	17	13	33	22	5	0.0259	1.000	1.000
327	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	33	AKT1(2), APC(9), AR(5), ASAH1(2), BRAF(4), CAMP(1), DAG1(3), EGFR(9), GNA11(1), GNA15(1), GNAI1(2), ITPKA(1), ITPKB(3), ITPR1(7), ITPR2(12), ITPR3(5), KCNJ3(4), MAPK10(2), MAPK14(1), PHKA2(5), PIK3CD(2), PIK3R1(5), PITX2(2), RAF1(4), SRC(3)	51066769	95	79	92	16	10	17	15	32	20	1	0.0145	1.000	1.000
328	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	26	ALDH3B1(4), ALDH3B2(3), AOC2(4), AOC3(2), DDC(3), EPX(3), ESCO1(2), ESCO2(1), GOT1(3), GOT2(2), HPD(2), LPO(1), MAOA(2), MAOB(2), MPO(6), PNPLA3(3), PRDX6(2), SH3GLB1(3), TAT(2), TPO(4)	32788441	54	50	53	10	7	7	11	14	15	0	0.0828	1.000	1.000
329	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	18	CHUK(2), IKBKAP(2), IKBKB(3), LTA(1), MAP3K1(7), NFKB1(2), NFKBIA(2), RELA(6), RIPK1(1), TANK(1), TNFAIP3(2), TNFRSF1B(1), TRAF2(1), TRAF3(1)	22639343	32	29	29	7	3	7	0	9	12	1	0.431	1.000	1.000
330	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	28	AMDHD2(3), CHIA(5), CHIT1(5), CMAS(1), CYB5R1(2), CYB5R3(2), GFPT1(2), GFPT2(1), GNE(1), GNPDA1(1), GNPNAT1(1), HEXA(4), HK1(6), MTMR1(2), MTMR2(3), MTMR6(1), NAGK(3), NANS(3), PHPT1(1), RENBP(4)	28022287	51	48	51	10	7	6	8	17	12	1	0.0831	1.000	1.000
331	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(6), ARHGEF1(2), GNA12(1), GNA13(4), GNB1(3), MYL2(1), MYLK(4), PLCB1(3), PPP1R12B(2), PRKCA(2), ROCK1(5)	20532945	33	33	33	9	3	2	2	17	9	0	0.665	1.000	1.000
332	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(3), CD28(1), CSK(4), CTLA4(3), DAG1(3), DTYMK(1), EPHB2(2), FBXW7(6), GRAP2(1), GRB2(2), ITK(1), ITPKA(1), ITPKB(3), LCK(1), LCP2(3), NCK1(1), NFAT5(8), NFKB1(2), NFKB2(3), NFKBIA(2), NFKBIB(2), NFKBIL1(2), PAK1(3), PAK2(4), PAK3(1), PAK4(3), PAK6(5), PAK7(3), PLCG1(4), PTPRC(8), RAF1(4), RASGRP1(3), RASGRP2(2), RASGRP3(2), RASGRP4(3), SOS1(8), SOS2(7), VAV1(4), ZAP70(1)	55484143	120	99	119	20	13	16	20	40	31	0	0.0101	1.000	1.000
333	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), DAG1(3), ITPKA(1), ITPKB(3), ITPR1(7), ITPR2(12), ITPR3(5), NFAT5(8), PDE6A(1), PDE6B(6), PDE6C(3), SLC6A13(7)	35983094	61	56	61	11	6	7	14	22	12	0	0.0561	1.000	1.000
334	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	26	ABAT(1), ACADL(3), ACADM(1), ACADSB(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(4), ALDH2(4), ALDH3A2(2), AOC2(4), AOC3(2), CNDP1(4), DPYD(5), DPYS(4), ECHS1(3), EHHADH(6), GAD1(2), GAD2(2), HADHA(4), MLYCD(3), SMS(2), UPB1(1)	27746796	60	58	59	15	3	9	15	17	14	2	0.199	1.000	1.000
335	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	40	ACY3(2), ALDH1B1(4), ALDH2(4), ALDH3A2(2), ALDH3B1(4), ALDH3B2(3), ALDH7A1(1), AMDHD1(2), AOC2(4), AOC3(2), ASPA(1), CNDP1(4), DDC(3), FTCD(2), HAL(1), HARS(1), HARS2(1), HDC(1), HNMT(2), LCMT1(1), LCMT2(4), MAOA(2), MAOB(2), METTL2B(1), PRMT2(2), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(2), PRMT8(3), PRPS1(1), PRPS2(4), UROC1(2)	38177979	75	66	74	14	7	14	13	24	17	0	0.0289	1.000	1.000
336	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	37	ACAA1(3), ACAD8(2), ACAD9(2), ADH1A(2), ADH1B(2), ADH4(2), ADH5(1), ADH6(2), ADHFE1(3), AKR1B10(2), AKR1C4(1), ALDH1B1(4), ALDH2(4), ALDH3A2(2), ALDH7A1(1), BAAT(2), CEL(3), CYP27A1(1), HADHB(4), LIPA(1), RDH11(4), RDH13(1), SLC27A5(3), SOAT1(4), SOAT2(3), SRD5A1(1)	30705319	60	56	57	13	6	4	7	26	17	0	0.301	1.000	1.000
337	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(3), ELK1(1), FOS(1), GRB2(2), HRAS(1), IL2RA(2), IL2RB(2), JAK1(6), JAK3(4), JUN(2), LCK(1), MAPK3(3), RAF1(4), SHC1(4), SOS1(8), STAT5A(3), STAT5B(3), SYK(2)	23192421	52	50	51	13	7	7	9	15	14	0	0.358	1.000	1.000
338	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD28(1), CD86(3), HLA-DRA(1), HLA-DRB1(6), IFNGR1(3), IFNGR2(2), IL12RB1(4), IL12RB2(2), IL18R1(1), IL2RA(2), IL4(1), IL4R(4)	12513657	30	28	30	10	5	3	2	9	11	0	0.734	1.000	1.000
339	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	21	CSNK2A1(3), FOS(1), GRB2(2), HRAS(1), JAK2(7), JUN(2), MAPK3(3), PIK3R1(5), PLCG1(4), PRKCA(2), RAF1(4), RASA1(7), SHC1(4), SOS1(8), STAT1(5), STAT3(3), STAT5A(3), STAT5B(3), THPO(1)	27670915	68	61	66	15	7	9	8	25	19	0	0.397	1.000	1.000
340	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	20	CSNK2A1(3), ELK1(1), FOS(1), GRB2(2), HRAS(1), IL6R(2), IL6ST(6), JAK1(6), JAK2(7), JAK3(4), JUN(2), MAPK3(3), PTPN11(2), RAF1(4), SHC1(4), SOS1(8), STAT3(3)	23498579	59	55	59	15	5	7	10	23	14	0	0.449	1.000	1.000
341	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	16	ABCC2(4), ABCG2(2), BCHE(3), CES1(8), CES2(2), CYP3A5(1), UGT1A1(5), UGT1A3(1), UGT1A4(2), UGT1A5(2), UGT1A6(3), UGT1A7(3), UGT1A9(5)	19863911	41	36	39	11	2	3	9	14	13	0	0.616	1.000	1.000
342	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(2), CREBBP(9), EP300(16), IKBKB(3), IL1B(1), MAP2K3(3), MAP3K7(3), MAPK11(1), MAPK14(1), NFKB1(2), NFKBIA(2), NR3C1(4), RELA(6), TGFBR1(1), TGFBR2(2), TLR2(2), TNF(1)	29534966	59	50	53	12	4	7	7	18	21	2	0.282	1.000	1.000
343	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(2), CHUK(2), IKBKB(3), IL4(1), JUN(2), MAP3K1(7), MAP3K5(5), MAP4K5(4), MAPK14(1), NFKB1(2), NFKBIA(2), RELA(6), TNFRSF9(1), TNFSF9(1), TRAF2(1)	19715506	40	36	37	10	2	5	1	14	17	1	0.777	1.000	1.000
344	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(3), DYRK1B(1), GLI2(4), GLI3(7), GSK3B(3), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), SHH(3), SMO(4), SUFU(3)	15784321	38	35	36	11	5	5	3	13	12	0	0.569	1.000	1.000
345	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	17	CSNK2A1(3), DPM2(1), ELK1(1), FOS(1), GRB2(2), HRAS(1), JUN(2), MAPK3(3), NGFR(1), PIK3R1(5), PLCG1(4), RAF1(4), SHC1(4), SOS1(8)	16551872	40	38	39	11	5	7	4	15	9	0	0.597	1.000	1.000
346	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	23	ATM(19), BMPR1B(2), CCND2(1), CDK4(6), CDKN1B(1), DAZL(2), ESR2(4), FSHR(2), MLH1(3), NCOR1(7), NR5A1(1), NRIP1(5), PGR(5), PRLR(3), PTGER2(1), SMPD1(4), VDR(2), ZP2(6)	33163002	74	63	69	16	9	11	8	23	22	1	0.189	1.000	1.000
347	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	33	GTF2A1(2), GTF2B(2), GTF2E1(1), GTF2E2(3), GTF2F1(1), GTF2F2(1), GTF2H1(2), GTF2H2(1), GTF2H4(1), GTF2I(4), GTF2IRD1(2), STON1(3), TAF1(7), TAF10(1), TAF1L(9), TAF2(6), TAF4(7), TAF4B(8), TAF5(2), TAF5L(3), TAF6(2), TAF7(2), TAF7L(7), TAF9B(2), TBPL2(1)	36296949	80	72	76	17	5	13	13	27	22	0	0.0911	1.000	1.000
348	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(4), IL22RA1(3), IL22RA2(1), JAK1(6), JAK2(7), JAK3(4), SOCS3(1), STAT1(5), STAT3(3), STAT5A(3), STAT5B(3), TYK2(7)	18363912	47	45	45	13	4	0	9	20	14	0	0.801	1.000	1.000
349	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(5), CTH(2), GGT1(4), LCMT1(1), LCMT2(4), MARS(3), MARS2(4), MAT1A(1), MAT2B(1), METTL2B(1), PAPSS1(2), PAPSS2(4), PRMT2(2), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(2), PRMT8(3), SCLY(3), SEPHS1(1), SEPHS2(4)	24467737	54	50	54	14	4	7	14	14	15	0	0.350	1.000	1.000
350	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	ACVR1(1), APC(9), ATF2(2), AXIN1(4), BMP10(1), BMP2(1), BMP4(1), BMP5(1), BMP7(5), BMPR1A(1), BMPR2(5), CHRD(5), CTNNB1(2), DVL1(1), FZD1(3), GATA4(2), GSK3B(3), MAP3K7(3), MYL2(1), NKX2-5(3), NOG(2), NPPA(1), NPPB(1), RFC1(5), TGFB2(2), TGFBR1(1), TGFBR2(2), TGFBR3(3), WNT1(2)	35696562	73	62	71	16	11	6	5	29	21	1	0.221	1.000	1.000
351	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	38	AKT1(2), AKT2(5), AKT3(3), BAD(1), BCR(1), BLNK(1), CD19(1), CSK(4), DAG1(3), EPHB2(2), GRB2(2), ITPKA(1), ITPKB(3), LYN(1), MAP2K2(1), NFAT5(8), NFKB1(2), NFKB2(3), NFKBIA(2), NFKBIB(2), NFKBIL1(2), PI3(1), PIK3CD(2), PIK3R1(5), PLCG2(4), PPP1R13B(4), RAF1(4), SHC1(4), SOS1(8), SOS2(7), SYK(2), VAV1(4)	49441181	95	83	95	17	12	13	16	33	21	0	0.0211	1.000	1.000
352	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	ACHE(1), CHAT(5), DBH(2), DDC(3), GAD1(2), GAD2(2), HDC(1), MAOA(2), PAH(5), SLC18A3(2), TH(4), TPH1(2)	13885177	31	30	29	10	3	5	7	8	8	0	0.669	1.000	1.000
353	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	25	CSNK2A1(3), ELK1(1), FOS(1), GRB2(2), HRAS(1), JAK1(6), JUN(2), MAP3K1(7), MAPK3(3), PDGFRA(6), PIK3R1(5), PLCG1(4), PRKCA(2), RAF1(4), RASA1(7), SHC1(4), SOS1(8), STAT1(5), STAT3(3), STAT5A(3)	32676953	77	69	75	17	9	12	6	25	25	0	0.362	1.000	1.000
354	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BAD(1), CASP8(1), MAP3K1(7), MAPK3(3), NFKB1(2), NSMAF(6), RAF1(4), RELA(6), RIPK1(1), SMPD1(4), TNFRSF1A(1), TRADD(2), TRAF2(1)	20354567	39	35	35	10	4	6	6	10	12	1	0.455	1.000	1.000
355	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(8), BST1(2), CD38(1), ENPP1(4), ENPP3(2), NADK(1), NADSYN1(1), NMNAT2(2), NMNAT3(2), NNMT(1), NNT(7), NT5C1A(2), NT5C1B(2), NT5C2(1), NT5M(2), NUDT12(2), QPRT(1)	21512856	41	39	40	11	3	3	4	23	8	0	0.597	1.000	1.000
356	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(8), ACE2(2), AGT(4), AGTR1(2), AGTR2(1), ANPEP(8), CMA1(1), CTSA(1), ENPEP(5), LNPEP(3), MAS1(1), MME(5), REN(1), THOP1(1)	21043556	43	38	39	12	2	6	12	13	10	0	0.583	1.000	1.000
357	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(2), AGT(4), AGTR1(2), AGTR2(1), CMA1(1), COL4A1(3), COL4A2(2), COL4A3(7), COL4A4(4), COL4A5(8), COL4A6(7), REN(1)	25559695	42	39	42	12	4	12	5	16	5	0	0.300	1.000	1.000
358	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	CISH(2), IL6R(2), JAK1(6), JAK2(7), JAK3(4), PIAS3(3), PTPRU(4), SRC(3), STAT3(3)	15110643	34	30	34	10	2	4	5	13	10	0	0.732	1.000	1.000
359	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	61	APAF1(3), ATM(19), ATR(12), BAI1(5), BID(2), CASP8(1), CASP9(2), CCNB1(1), CCNB2(6), CCNB3(4), CCND2(1), CCNE1(2), CCNE2(4), CCNG1(1), CCNG2(2), CD82(3), CDK2(2), CDK4(6), CDK6(1), CDKN1A(3), CHEK1(1), CHEK2(2), FAS(2), GADD45B(1), GTSE1(4), IGFBP3(1), PERP(1), PPM1D(2), RCHY1(3), RFWD2(3), RRM2(1), SERPINB5(5), SESN1(2), SFN(1), STEAP3(2), TNFRSF10B(1), TP53I3(4), TP73(4), TSC2(12), ZMAT3(1)	60299984	133	109	127	25	16	22	18	33	42	2	0.0157	1.000	1.000
360	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	21	AKT1(2), BCR(1), CRKL(1), FOS(1), GRB2(2), HRAS(1), JAK2(7), JUN(2), MAP3K1(7), MAPK3(3), MYC(1), PIK3R1(5), RAF1(4), SOS1(8), STAT1(5), STAT5A(3), STAT5B(3)	25443827	56	53	55	14	5	7	7	23	14	0	0.499	1.000	1.000
361	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(4), AGTR2(1), CALM2(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), F2(3), FYN(2), GNA11(1), GNAI1(2), GNB1(3), GRB2(2), HRAS(1), JAK2(7), MAP2K2(1), MAPK14(1), MAPK3(3), MAPT(4), MYLK(4), PLCG1(4), PRKCA(2), PTK2B(3), RAF1(4), SHC1(4), SOS1(8), STAT1(5), STAT3(3), STAT5A(3), SYT1(1)	41878239	82	72	80	17	6	11	11	33	21	0	0.216	1.000	1.000
362	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	19	CSNK2A1(3), ELK1(1), FOS(1), GRB2(2), HRAS(1), IGF1R(3), IRS1(5), JUN(2), MAPK3(3), PIK3R1(5), PTPN11(2), RAF1(4), RASA1(7), SHC1(4), SOS1(8)	22005737	51	47	51	14	9	11	3	17	11	0	0.403	1.000	1.000
363	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	44	ACAA1(3), ACADL(3), ACADM(1), ACADS(3), ACADSB(1), ACAT1(1), ACOX1(2), ACOX3(5), ACSL1(4), ACSL4(1), ACSL5(1), ACSL6(5), ADH1A(2), ADH1B(2), ADH4(2), ADH5(1), ADH6(2), ADHFE1(3), ALDH1B1(4), ALDH2(4), ALDH3A2(2), ALDH7A1(1), CPT1A(2), CPT1C(4), CPT2(2), CYP4A11(5), CYP4A22(1), ECHS1(3), EHHADH(6), HADH(1), HADHA(4), HADHB(4), HSD17B4(1)	45701714	86	81	81	19	7	13	17	31	17	1	0.0907	1.000	1.000
364	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	22	CHUK(2), IKBKB(3), IL1R1(3), IRAK1(3), MAP3K1(7), MAP3K7(3), NFKB1(2), NFKBIA(2), RELA(6), RIPK1(1), TLR4(3), TNF(1), TNFAIP3(2), TNFRSF1A(1), TNFRSF1B(1), TRADD(2), TRAF6(2)	24297343	44	38	41	11	5	10	3	9	15	2	0.427	1.000	1.000
365	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(1), ACP2(1), ACP5(2), ALPI(3), ALPL(4), ALPP(5), ALPPL2(5), CYP19A1(2), CYP1A1(1), CYP1A2(4), CYP2A13(5), CYP2A6(4), CYP2A7(2), CYP2B6(1), CYP2C18(1), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP2D6(4), CYP2E1(1), CYP2F1(4), CYP2J2(3), CYP3A5(1), CYP3A7(2), CYP4B1(3), CYP51A1(2)	28654943	64	54	64	16	13	12	3	25	11	0	0.156	1.000	1.000
366	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	29	ACY1(3), AGMAT(2), ALDH18A1(2), ALDH1B1(4), ALDH2(4), ALDH3A2(2), ALDH7A1(1), AMD1(2), AOC2(4), AOC3(2), ARG1(1), ARG2(1), ASL(4), ASS1(3), CPS1(5), GATM(1), MAOA(2), MAOB(2), NAGS(1), ODC1(2), OTC(1), SAT1(1), SAT2(1), SMS(2)	28273900	53	51	53	13	3	7	11	18	14	0	0.317	1.000	1.000
367	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	27	ADRBK1(2), AKT1(2), AKT2(5), AKT3(3), DAG1(3), ITPKA(1), ITPKB(3), ITPR1(7), ITPR2(12), ITPR3(5), NFKB1(2), NFKB2(3), NFKBIA(2), NFKBIB(2), NFKBIL1(2), PDK1(1), PHKA2(5), PIK3CB(5), PITX2(2), PLD1(2), PLD2(5), PLD3(3)	44709441	77	66	75	15	11	12	13	24	17	0	0.0308	1.000	1.000
368	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	15	AKT1(2), MAP2K2(1), MAP2K3(3), MAP3K1(7), MAPK14(1), MAPK3(3), NFKB1(2), PIK3R1(5), RB1(4), RELA(6), SP1(2)	17485075	36	34	33	10	2	6	1	13	11	3	0.808	1.000	1.000
369	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(1), ALDH4A1(2), CAD(12), CPS1(5), EPRS(4), GAD1(2), GAD2(2), GCLC(4), GFPT1(2), GFPT2(1), GLS(6), GLS2(4), GLUD2(7), GLUL(2), GMPS(1), GNPNAT1(1), GOT1(3), GOT2(2), GPT(4), GPT2(2), GSR(1), GSS(1), NADSYN1(1), NAGK(3), PPAT(3), QARS(1)	39509883	77	67	71	17	7	8	17	26	18	1	0.227	1.000	1.000
370	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	17	DNAJA3(1), IFNGR1(3), IFNGR2(2), IKBKB(3), JAK2(7), NFKB1(2), NFKBIA(2), RB1(4), RELA(6), TNF(1), TNFRSF1A(1), TNFRSF1B(1), USH1C(4), WT1(3)	17377959	40	37	37	12	2	4	3	12	16	3	0.903	1.000	1.000
371	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	26	ACAA1(3), ADH1A(2), ADH1B(2), ADH4(2), ADH6(2), ADHFE1(3), AKR1C4(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(4), ALDH2(4), ALDH3A2(2), BAAT(2), CEL(3), CYP27A1(1), HADHB(4), SOAT2(3), SRD5A1(1)	22244139	41	39	40	12	4	3	6	18	10	0	0.675	1.000	1.000
372	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	25	AKT1(2), AKT2(5), AKT3(3), CISH(2), GRB2(2), IARS(4), IL13RA1(2), IL4(1), IL4R(4), INPP5D(2), JAK1(6), JAK2(7), JAK3(4), PI3(1), PPP1R13B(4), RPS6KB1(2), SHC1(4), SOS1(8), SOS2(7), SRC(3), STAT6(5), TYK2(7)	34349153	85	71	84	20	7	12	16	29	21	0	0.211	1.000	1.000
373	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	79	AIFM1(6), AKT1(2), AKT2(5), AKT3(3), APAF1(3), ATM(19), BAD(1), BID(2), BIRC2(2), BIRC3(5), CAPN1(2), CAPN2(4), CASP10(3), CASP7(1), CASP8(1), CASP9(2), CFLAR(1), CHUK(2), CSF2RB(5), DFFA(1), DFFB(1), FAS(2), FASLG(2), IKBKB(3), IL1B(1), IL1R1(3), IL1RAP(4), IL3(1), IRAK1(3), IRAK3(4), IRAK4(1), NFKB1(2), NFKB2(3), NFKBIA(2), NTRK1(7), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PPP3CA(3), PPP3CC(3), PRKACA(2), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), RELA(6), RIPK1(1), TNF(1), TNFRSF10B(1), TNFRSF10C(2), TNFRSF1A(1), TRADD(2), TRAF2(1)	80167084	165	134	158	29	18	22	20	62	42	1	0.00803	1.000	1.000
374	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	21	ACAD8(2), ACAD9(2), ADH1A(2), ADH1B(2), ADH4(2), ADH5(1), ADH6(2), ADHFE1(3), DHRS2(1), ESCO1(2), ESCO2(1), PNPLA3(3), SH3GLB1(3)	24325921	26	25	25	8	1	3	2	13	7	0	0.793	1.000	1.000
375	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	29	A1BG(1), AKT1(2), AKT2(5), AKT3(3), BAD(1), DAPP1(2), GRB2(2), GSK3A(2), GSK3B(3), IARS(4), IGFBP1(1), INPP5D(2), PDK1(1), PPP1R13B(4), RPS6KA3(3), RPS6KB1(2), SFN(1), SHC1(4), SOS1(8), SOS2(7), TEC(5), YWHAB(1)	30929354	64	60	62	16	4	12	12	18	18	0	0.287	1.000	1.000
376	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	AGXT(2), AGXT2(1), AKR1B10(2), ALAS1(5), ALAS2(5), AOC2(4), AOC3(2), BHMT(7), CHDH(4), CHKB(2), CTH(2), DAO(1), DLD(4), DMGDH(4), GATM(1), GLDC(4), GNMT(1), MAOA(2), MAOB(2), PHGDH(3), PIPOX(2), PISD(1), PSAT1(2), RDH11(4), RDH13(1), SARDH(4), SARS(2), SHMT1(2), SHMT2(5), TARS(5), TARS2(7)	42587499	93	85	89	22	11	14	14	27	26	1	0.169	1.000	1.000
377	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(1), IARS(4), IARS2(3), ILVBL(3), LARS(7), LARS2(2), PDHA1(1), PDHA2(3), PDHB(1), VARS(4), VARS2(6)	17577080	35	31	35	10	2	7	6	11	9	0	0.457	1.000	1.000
378	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	23	ABL1(8), ATM(19), ATR(12), CCNA1(7), CCNE1(2), CDC25A(1), CDK2(2), CDK4(6), CDK6(1), CDKN1A(3), CDKN1B(1), E2F1(1), GSK3B(3), HDAC1(2), RB1(4), SKP2(1), TGFB2(2)	28773590	75	62	66	19	4	8	9	19	32	3	0.536	1.000	1.000
379	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	20	CFL1(1), CHN1(2), MAP3K1(7), MYL2(1), MYLK(4), NCF2(1), PAK1(3), PDGFRA(6), PIK3R1(5), PLD1(2), PPP1R12B(2), RALBP1(2), RPS6KB1(2), TRIO(9), VAV1(4), WASF1(1)	31689250	52	50	52	12	3	5	5	22	17	0	0.555	1.000	1.000
380	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	20	ATM(19), ATR(12), BRCA1(7), CCNB1(1), CDC25A(1), CDC25B(1), CDC25C(3), CDKN1A(3), CHEK1(1), CHEK2(2), EP300(16), MYT1(5), PRKDC(12), WEE1(2)	40678957	85	72	81	18	3	11	10	34	26	1	0.214	1.000	1.000
381	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	17	CALM2(1), CDKN1A(3), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), PLCG1(4), PPP3CA(3), PPP3CC(3), PRKCA(2), SP1(2), SP3(2), SYT1(1)	20011083	43	38	40	13	5	5	3	10	19	1	0.831	1.000	1.000
382	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(1), ARSB(1), ARSD(2), ARSE(2), CYP11B1(4), CYP11B2(2), HSD11B2(1), HSD17B2(1), HSD17B8(1), HSD3B1(1), SRD5A1(1), SULT1E1(2), SULT2A1(1), UGT1A1(5), UGT1A3(1), UGT1A4(2), UGT1A5(2), UGT1A6(3), UGT1A7(3), UGT1A9(5), UGT2B15(1), UGT2B4(4)	27033091	46	42	46	13	3	3	11	12	17	0	0.451	1.000	1.000
383	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	44	AADAC(1), ABAT(1), ACADS(3), ACAT1(1), ACSM1(3), AKR1B10(2), ALDH1B1(4), ALDH2(4), ALDH3A2(2), ALDH7A1(1), BDH1(1), BDH2(1), DDHD1(2), ECHS1(3), EHHADH(6), GAD1(2), GAD2(2), HADH(1), HADHA(4), HMGCL(2), HMGCS1(2), HMGCS2(1), HSD17B4(1), ILVBL(3), L2HGDH(1), OXCT1(2), PDHA1(1), PDHA2(3), PDHB(1), PLA1A(3), PRDX6(2), RDH11(4), RDH13(1)	39693909	71	66	69	17	8	11	13	24	15	0	0.180	1.000	1.000
384	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(2), GPLD1(2), PGAP1(6), PIGB(2), PIGC(1), PIGG(1), PIGK(1), PIGL(2), PIGM(2), PIGN(3), PIGO(5), PIGP(1), PIGQ(4), PIGS(1), PIGT(6), PIGU(1), PIGV(1), PIGZ(3)	24309100	44	41	40	13	3	8	4	16	12	1	0.638	1.000	1.000
385	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(4), AGTR1(2), ATF2(2), CALM2(1), EGFR(9), ELK1(1), GRB2(2), HRAS(1), JUN(2), MAP2K2(1), MAP3K1(7), MAPK3(3), MEF2A(2), MEF2D(1), PAK1(3), PRKCA(2), PTK2(3), PTK2B(3), RAF1(4), SHC1(4), SOS1(8), SRC(3), SYT1(1)	33840107	69	61	67	17	6	15	8	23	17	0	0.325	1.000	1.000
386	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(2), ALOX12(3), ALOX5(4), CBR1(4), CYP4F2(4), CYP4F3(2), EPX(3), GGT1(4), LPO(1), LTA4H(4), MPO(6), PLA2G4A(2), PLA2G6(4), PRDX1(1), PRDX5(1), PRDX6(2), PTGDS(1), PTGS1(2), PTGS2(5), TBXAS1(4), TPO(4)	27591028	63	58	61	17	7	6	16	18	15	1	0.420	1.000	1.000
387	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	21	ARHGAP5(6), DIAPH1(7), FYN(2), GSN(5), HRAS(1), ITGA1(8), ITGB1(7), MAPK3(3), MYL2(1), MYLK(4), PIK3R1(5), PTK2(3), PXN(3), RAF1(4), ROCK1(5), SHC1(4), SRC(3), TLN1(13)	35169158	84	74	83	20	6	10	9	30	29	0	0.459	1.000	1.000
388	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(1), AKT1(2), BDKRB2(1), CALM2(1), CHRM1(2), CHRNA1(3), FLT1(8), FLT4(14), KDR(6), NOS3(3), PDE2A(3), PDE3A(3), PDE3B(3), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PRKG1(4), PRKG2(3), RYR2(17), SLC7A1(3), SYT1(1), TNNI1(2)	41123979	90	81	90	22	16	15	8	33	18	0	0.126	1.000	1.000
389	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	13	ABL1(8), E2F1(1), MYC(1), PIK3R1(5), POLR1A(6), POLR1B(4), POLR1C(2), POLR1D(1), RB1(4)	16343092	32	29	32	10	2	6	1	12	9	2	0.758	1.000	1.000
390	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	55	ADH1A(2), ADH1B(2), ADH4(2), ADH5(1), ADH6(2), ADHFE1(3), ALDH3B1(4), ALDH3B2(3), AOC2(4), AOC3(2), AOX1(8), DBH(2), DCT(4), DDC(3), ECH1(2), ESCO1(2), ESCO2(1), FAH(1), GOT1(3), GOT2(2), HGD(3), HPD(2), LCMT1(1), LCMT2(4), MAOA(2), MAOB(2), METTL2B(1), PNPLA3(3), PRMT2(2), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(2), PRMT8(3), SH3GLB1(3), TAT(2), TH(4), TPO(4), TYR(5), TYRP1(4)	57842860	107	91	105	23	12	11	15	38	31	0	0.139	1.000	1.000
391	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(4), AP2A1(3), AP2M1(1), BIN1(3), CALM2(1), DNM1(4), EPN1(1), EPS15(2), PICALM(3), PPP3CA(3), PPP3CC(3), SYNJ1(6), SYNJ2(5), SYT1(1)	22148223	40	39	40	12	2	6	7	14	11	0	0.569	1.000	1.000
392	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	40	ALG1(1), ALG10(3), ALG10B(8), ALG11(4), ALG12(2), ALG13(5), ALG14(1), ALG3(3), ALG5(2), ALG6(3), ALG8(1), ALG9(2), B4GALT1(1), B4GALT3(2), DOLPP1(3), DPM1(1), MAN1A1(2), MAN1A2(1), MAN1B1(1), MAN2A1(3), MGAT2(1), MGAT3(1), MGAT4A(3), MGAT4B(1), MGAT5(4), MGAT5B(4), RFT1(1), RPN1(3), RPN2(1), ST6GAL1(1), STT3B(4)	41266086	73	60	72	16	4	14	4	24	27	0	0.255	1.000	1.000
393	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	25	ALDOA(2), ALDOB(3), ALDOC(1), G6PD(2), H6PD(3), PFKL(3), PFKM(3), PFKP(3), PGM1(1), PRPS1(1), PRPS1L1(2), PRPS2(4), RBKS(1), RPE(2), RPIA(2), TALDO1(1), TKT(2), TKTL1(2), TKTL2(5)	22799459	43	43	43	13	6	8	6	12	11	0	0.549	1.000	1.000
394	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(9), ASAH1(2), CAMP(1), CERK(6), CREB5(3), DAG1(3), EPHB2(2), FOS(1), ITPKA(1), ITPKB(3), JUN(2), MAP2K7(1), MAPK10(2), MAPK8IP1(4), MAPK8IP2(1), MAPK8IP3(2), MAPK9(2)	27735983	45	41	42	12	7	4	7	13	14	0	0.569	1.000	1.000
395	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	21	ACTA1(1), ADCY1(2), CCNB1(1), CDC25C(3), GNAI1(2), GNAS(6), GNB1(3), HRAS(1), MAPK3(3), MYT1(5), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), SRC(3)	18578089	40	38	40	12	5	6	3	20	6	0	0.545	1.000	1.000
396	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(8), CD2(2), CD33(3), CD5(1), IFNA1(1), IFNB1(2), IL3(1), IL4(1), ITGAX(8), TLR2(2), TLR4(3), TLR7(5), TLR9(1)	18230793	38	36	37	12	5	4	9	11	9	0	0.541	1.000	1.000
397	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	44	AADAT(2), AASDHPPT(3), AASS(8), ACAT1(1), AKR1B10(2), ALDH1B1(4), ALDH2(4), ALDH3A2(2), ALDH7A1(1), BBOX1(1), DOT1L(9), ECHS1(3), EHHADH(6), EHMT1(4), EHMT2(8), HADH(1), HADHA(4), HSD17B4(1), NSD1(13), OGDH(8), OGDHL(2), PIPOX(2), PLOD1(2), PLOD2(5), RDH11(4), RDH13(1), SETD1A(8), SETD7(1), SETDB1(6), SHMT1(2), SHMT2(5), SPCS1(2), SUV39H2(5), TMLHE(1)	53636779	131	111	128	29	10	22	20	47	32	0	0.0883	1.000	1.000
398	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(6), ADRBK2(2), ARRB2(1), CALM2(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CLCA1(3), CLCA4(2), CNGA3(4), CNGA4(3), CNGB1(6), GUCA1B(1), PDC(1), PDE1C(2), PRKACA(2), PRKACB(2), PRKACG(2), PRKG1(4), PRKG2(3), PRKX(2)	30876627	52	50	49	14	8	6	4	22	12	0	0.463	1.000	1.000
399	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	12	CREBBP(9), DAXX(6), HRAS(1), PAX3(2), PML(2), RARA(4), RB1(4), SIRT1(5), SP100(2), TNF(1), TNFRSF1A(1), TNFRSF1B(1)	17648356	38	37	38	12	5	4	5	10	12	2	0.727	1.000	1.000
400	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(9), EP300(16), LPL(3), NCOA1(3), NCOA2(11), PPARG(2)	18385145	44	36	35	14	3	4	5	11	21	0	0.712	1.000	1.000
401	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	50	ACTA1(1), AGT(4), AKT1(2), CALM2(1), CALR(2), CAMK1(3), CAMK1G(3), CAMK4(3), CREBBP(9), CSNK1A1(2), ELSPBP1(2), F2(3), GATA4(2), GSK3B(3), HAND2(1), HRAS(1), MAPK14(1), MAPK3(3), MYH2(9), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), NKX2-5(3), NPPA(1), PIK3R1(5), PPP3CA(3), PPP3CC(3), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), RAF1(4), RPS6KB1(2), SYT1(1)	47536759	109	92	104	27	14	11	9	35	40	0	0.363	1.000	1.000
402	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	36	ACACA(9), ACAT1(1), ADH5(1), AKR1B1(3), ALDH1A1(1), ALDH1A2(1), ALDH1B1(4), ALDH2(4), ALDH3A2(2), DLAT(2), DLD(4), GLO1(1), GRHPR(2), HAGH(1), LDHB(2), LDHC(3), MDH1(2), MDH2(1), ME1(1), ME2(3), ME3(2), PC(8), PCK1(5), PDHA1(1), PDHA2(3), PDHB(1), PKLR(1)	35734439	69	61	68	18	4	9	14	18	23	1	0.414	1.000	1.000
403	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(3), COL4A2(2), COL4A3(7), COL4A4(4), COL4A5(8), COL4A6(7), P4HB(3), SLC23A1(6), SLC23A2(2), SLC2A1(2), SLC2A3(2)	25533935	46	42	46	16	4	12	4	17	9	0	0.671	1.000	1.000
404	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM2(1), CHUK(2), EGR2(1), EGR3(2), MAP3K1(7), MYC(1), NFATC1(4), NFATC2(8), NFKB1(2), NFKBIA(2), PLCG1(4), PPP3CA(3), PPP3CC(3), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), RELA(6), SYT1(1), VIPR2(2)	27229521	59	54	53	17	8	6	1	17	26	1	0.778	1.000	1.000
405	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	54	ADH1A(2), ADH1B(2), ADH4(2), ADH5(1), ADH6(2), ADHFE1(3), AGK(6), AGPAT1(1), AKR1A1(2), AKR1B1(3), ALDH1B1(4), ALDH2(4), ALDH3A2(2), ALDH7A1(1), CEL(3), DAK(3), DGAT1(2), DGAT2(1), DGKA(4), DGKB(3), DGKD(3), DGKE(5), DGKG(5), DGKH(6), DGKI(1), DGKQ(3), DGKZ(5), GK(1), GK2(3), GLA(1), GLB1(5), GPAM(5), LCT(7), LIPA(1), LIPC(1), LIPF(1), LPL(3), PNLIP(4), PNPLA3(3), PPAP2B(1), PPAP2C(3)	57846106	118	101	117	28	14	16	16	42	30	0	0.106	1.000	1.000
406	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(1), CAPN1(2), CAPN2(4), EGF(5), EGFR(9), HRAS(1), ITGA1(8), ITGB1(7), MAPK3(3), MYL2(1), MYLK(4), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PTK2(3), PXN(3), TLN1(13)	32783740	74	66	71	20	8	7	6	30	23	0	0.582	1.000	1.000
407	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	27	AGA(1), ARSB(1), FUCA1(2), FUCA2(1), GALNS(6), GBA(3), GLB1(5), GNS(4), GUSB(5), HEXA(4), HGSNAT(3), HPSE(2), HPSE2(4), HYAL1(2), HYAL2(1), IDS(2), LCT(7), MAN2B1(1), MAN2B2(2), MAN2C1(5), MANBA(2), NAGLU(2), NEU1(1)	32184866	66	56	66	18	8	9	9	26	14	0	0.320	1.000	1.000
408	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	22	ALDOA(2), ALDOB(3), ALDOC(1), G6PD(2), H6PD(3), PFKM(3), PFKP(3), PGM1(1), PRPS1(1), PRPS1L1(2), PRPS2(4), RBKS(1), RPE(2), RPIA(2), TAL1(3), TALDO1(1), TKT(2)	18740246	36	35	36	12	5	5	6	10	10	0	0.723	1.000	1.000
409	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT1(2), AKT2(5), AKT3(3), ANKRD6(2), APC(9), AXIN1(4), AXIN2(1), CSNK1A1(2), CTNNB1(2), DACT1(2), DVL1(1), FSTL1(2), GSK3A(2), GSK3B(3), LRP1(12), MVP(5), NKD1(4), NKD2(4), PTPRA(5), SENP2(1), WIF1(5)	40007373	76	68	71	19	6	12	11	25	22	0	0.284	1.000	1.000
410	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	15	CREBBP(9), EP300(16), FYN(2), IL7R(1), JAK1(6), JAK3(4), LCK(1), PIK3R1(5), PTK2B(3), STAT5A(3), STAT5B(3)	25759416	53	49	49	15	4	6	10	15	18	0	0.624	1.000	1.000
411	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	41	CALM2(1), CD3E(1), CD3G(2), ELK1(1), FOS(1), FYN(2), GRB2(2), HRAS(1), JUN(2), LCK(1), MAP3K1(7), MAPK3(3), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), NFKB1(2), NFKBIA(2), PIK3R1(5), PLCG1(4), PPP3CA(3), PPP3CC(3), PRKCA(2), PTPN7(1), RAF1(4), RASA1(7), RELA(6), SHC1(4), SOS1(8), SYT1(1), VAV1(4), ZAP70(1)	44851586	103	90	97	25	12	17	8	31	34	1	0.454	1.000	1.000
412	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	35	ANAPC1(4), ANAPC10(1), ANAPC2(2), ANAPC4(6), ANAPC5(3), ANAPC7(2), BTRC(2), CDC16(4), CDC20(3), CDC23(2), CUL1(5), CUL2(4), FBXW11(2), FBXW7(6), FZR1(3), ITCH(1), RBX1(1), SKP2(1), SMURF1(1), SMURF2(3), TCEB2(1), UBA1(4), UBE2D1(2), UBE2D2(1), UBE2D3(2), UBE2E2(1), WWP1(8), WWP2(4)	36973769	79	74	75	19	7	7	16	24	24	1	0.327	1.000	1.000
413	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	28	ACTR2(2), ARHGAP1(1), ARHGAP5(6), ARHGAP6(2), ARHGEF1(2), ARHGEF11(5), ARHGEF5(3), ARPC1B(1), BAIAP2(2), CFL1(1), DIAPH1(7), GSN(5), MYL2(1), MYLK(4), OPHN1(2), PIP5K1A(2), PIP5K1B(1), PPP1R12B(2), ROCK1(5), SRC(3), TLN1(13), VCL(2)	43752436	72	65	71	15	3	8	9	25	27	0	0.323	1.000	1.000
414	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	187	ACTG1(4), ACTN1(1), ACTN2(3), ACTN4(3), AKT1(2), AKT2(5), AKT3(3), ARHGAP5(6), BAD(1), BCAR1(6), BIRC2(2), BIRC3(5), BRAF(4), CAPN2(4), CAV2(2), CAV3(1), CCND2(1), CDC42(1), CHAD(3), COL11A1(9), COL11A2(5), COL1A1(6), COL1A2(10), COL2A1(6), COL3A1(3), COL4A1(3), COL4A2(2), COL4A4(4), COL4A6(7), COL5A1(8), COL5A2(6), COL5A3(12), COL6A1(3), COL6A2(7), COL6A3(20), COL6A6(17), CRKL(1), CTNNB1(2), DIAPH1(7), DOCK1(3), EGF(5), EGFR(9), ELK1(1), ERBB2(8), FARP2(3), FIGF(1), FLNA(6), FLNB(7), FLNC(10), FLT1(8), FN1(8), FYN(2), GRB2(2), GSK3B(3), HGF(1), HRAS(1), IBSP(1), IGF1R(3), ILK(4), ITGA1(8), ITGA10(4), ITGA11(6), ITGA2(4), ITGA2B(1), ITGA3(6), ITGA4(3), ITGA5(5), ITGA6(6), ITGA7(6), ITGA8(3), ITGA9(3), ITGAV(1), ITGB1(7), ITGB3(3), ITGB4(7), ITGB5(6), ITGB6(2), ITGB7(4), ITGB8(1), JUN(2), KDR(6), LAMA1(11), LAMA2(9), LAMA3(10), LAMA4(9), LAMA5(9), LAMB1(16), LAMB2(7), LAMB3(4), LAMB4(5), LAMC1(5), LAMC2(6), LAMC3(8), MAPK10(2), MAPK3(3), MAPK9(2), MYL2(1), MYL7(2), MYL9(1), MYLK(4), MYLK2(1), PAK1(3), PAK2(4), PAK3(1), PAK4(3), PAK6(5), PAK7(3), PARVA(1), PARVB(1), PARVG(2), PDGFC(1), PDGFD(4), PDGFRA(6), PDGFRB(3), PGF(2), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PIP5K1C(4), PPP1CA(1), PPP1CC(2), PPP1R12A(3), PRKCA(2), PRKCG(6), PTK2(3), PXN(3), RAC2(1), RAC3(1), RAF1(4), RAP1A(1), RAPGEF1(5), RELN(7), ROCK1(5), ROCK2(3), SHC1(4), SHC2(4), SHC3(1), SHC4(1), SOS1(8), SOS2(7), SPP1(3), SRC(3), THBS2(3), THBS3(5), THBS4(2), TLN1(13), TLN2(11), TNC(13), TNN(2), TNR(9), TNXB(11), VAV1(4), VAV2(4), VAV3(1), VCL(2), VEGFA(1), VEGFC(2), VTN(1), VWF(15), ZYX(1)	358915253	734	391	717	206	77	95	91	260	206	5	0.262	1.000	1.000
415	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	167	ADCY1(2), ADCY2(7), ADCY3(6), ADCY4(3), ADCY7(1), ADCY8(12), ADCY9(7), ADORA2A(5), ADORA2B(1), ADRA1A(4), ADRB2(2), AGTR1(2), ATP2A1(7), ATP2A2(7), ATP2A3(5), ATP2B1(4), ATP2B3(2), ATP2B4(4), AVPR1A(1), BDKRB1(1), BDKRB2(1), BST1(2), CACNA1A(14), CACNA1B(5), CACNA1C(17), CACNA1D(9), CACNA1E(3), CACNA1F(4), CACNA1G(10), CACNA1H(7), CACNA1I(6), CACNA1S(14), CALM2(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(3), CCKAR(4), CCKBR(3), CD38(1), CHRM1(2), CHRM2(6), CHRM3(3), CHRM5(2), CHRNA7(2), CYSLTR1(1), DRD1(1), EDNRB(3), EGFR(9), ERBB2(8), ERBB3(6), ERBB4(10), F2R(2), GNA11(1), GNA15(1), GNAS(6), GRIN1(2), GRIN2A(8), GRIN2D(2), GRM1(4), GRM5(8), GRPR(2), HRH2(1), HTR2A(1), HTR2B(1), HTR2C(1), HTR4(2), HTR6(2), HTR7(2), ITPKA(1), ITPKB(3), ITPR1(7), ITPR2(12), ITPR3(5), LTB4R2(1), MYLK(4), MYLK2(1), NOS1(10), NOS3(3), NTSR1(3), OXTR(1), P2RX1(3), P2RX2(4), P2RX3(3), P2RX5(1), P2RX7(2), PDE1A(1), PDE1B(5), PDE1C(2), PDGFRA(6), PDGFRB(3), PHKA1(10), PHKA2(5), PHKB(4), PHKG1(3), PHKG2(1), PLCB1(3), PLCB2(4), PLCB3(3), PLCB4(5), PLCD1(3), PLCD3(1), PLCD4(3), PLCE1(6), PLCG1(4), PLCG2(4), PLCZ1(3), PPID(1), PPP3CA(3), PPP3CC(3), PRKACA(2), PRKACB(2), PRKACG(2), PRKCA(2), PRKCG(6), PRKX(2), PTAFR(1), PTGFR(5), PTK2B(3), RYR1(23), RYR2(17), RYR3(18), SLC25A4(2), SLC25A5(3), SLC25A6(2), SLC8A1(3), SLC8A2(3), SLC8A3(4), SPHK1(1), SPHK2(1), TACR1(1), TACR2(1), TACR3(2), TBXA2R(4), TRHR(2), TRPC1(3), VDAC2(1), VDAC3(2)	269778931	559	349	543	164	99	74	59	198	129	0	0.179	1.000	1.000
416	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	245	ACVR1B(3), ACVR1C(3), AKT1(2), AKT2(5), AKT3(3), ARRB1(3), ARRB2(1), ATF2(2), ATF4(2), BDNF(2), BRAF(4), CACNA1A(14), CACNA1B(5), CACNA1C(17), CACNA1D(9), CACNA1E(3), CACNA1F(4), CACNA1G(10), CACNA1H(7), CACNA1I(6), CACNA1S(14), CACNA2D1(6), CACNA2D4(4), CACNB1(4), CACNB2(1), CACNB4(2), CACNG2(2), CACNG3(2), CACNG4(1), CACNG5(1), CACNG6(1), CACNG7(1), CACNG8(1), CDC25B(1), CDC42(1), CHUK(2), CRKL(1), DAXX(6), DUSP10(1), DUSP16(1), DUSP3(2), DUSP4(1), DUSP5(1), DUSP6(2), DUSP8(1), DUSP9(2), ECSIT(5), EGF(5), EGFR(9), ELK1(1), ELK4(2), FAS(2), FASLG(2), FGF1(2), FGF10(2), FGF11(1), FGF12(1), FGF13(1), FGF14(1), FGF19(2), FGF20(1), FGF21(1), FGF3(4), FGF6(4), FGF7(2), FGFR1(6), FGFR2(4), FGFR3(7), FGFR4(3), FLNA(6), FLNB(7), FLNC(10), FOS(1), GADD45B(1), GNA12(1), GNG12(1), GRB2(2), HRAS(1), IKBKB(3), IL1B(1), IL1R1(3), IL1R2(8), JUN(2), KRAS(3), MAP2K2(1), MAP2K3(3), MAP2K5(3), MAP2K7(1), MAP3K1(7), MAP3K10(4), MAP3K12(4), MAP3K13(2), MAP3K2(2), MAP3K3(2), MAP3K4(7), MAP3K5(5), MAP3K6(3), MAP3K7(3), MAP3K8(1), MAP4K1(4), MAP4K3(6), MAP4K4(2), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(3), MAPK7(4), MAPK8IP1(4), MAPK8IP2(1), MAPK8IP3(2), MAPK9(2), MAPKAPK2(1), MAPT(4), MAX(5), MKNK1(2), MKNK2(1), MOS(1), MRAS(1), MYC(1), NF1(12), NFATC2(8), NFATC4(3), NFKB1(2), NFKB2(3), NLK(1), NR4A1(1), NRAS(2), NTRK1(7), NTRK2(2), PAK1(3), PAK2(4), PDGFRA(6), PDGFRB(3), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(4), PPM1A(2), PPM1B(3), PPP3CA(3), PPP3CC(3), PPP5C(2), PRKACA(2), PRKACB(2), PRKACG(2), PRKCA(2), PRKCG(6), PRKX(2), PTPN5(4), PTPN7(1), PTPRR(4), RAC2(1), RAC3(1), RAF1(4), RAP1A(1), RAPGEF2(8), RASA1(7), RASA2(2), RASGRF1(8), RASGRF2(4), RASGRP1(3), RASGRP2(2), RASGRP3(2), RASGRP4(3), RPS6KA3(3), RPS6KA4(2), RPS6KA5(2), RPS6KA6(1), SOS1(8), SOS2(7), STK3(1), TAOK2(3), TAOK3(2), TGFB2(2), TGFBR1(1), TGFBR2(2), TNF(1), TNFRSF1A(1), TRAF2(1), TRAF6(2), ZAK(4)	284905674	576	346	564	157	73	78	72	207	143	3	0.171	1.000	1.000
417	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	198	ABI2(2), ACTN1(1), ACTN2(3), ACTN4(3), APC(9), APC2(5), ARAF(1), ARHGEF1(2), ARHGEF12(5), ARHGEF4(2), ARHGEF6(4), ARHGEF7(5), ARPC1B(1), ARPC5L(1), BAIAP2(2), BCAR1(6), BDKRB1(1), BDKRB2(1), BRAF(4), CDC42(1), CFL1(1), CFL2(1), CHRM1(2), CHRM2(6), CHRM3(3), CHRM5(2), CRKL(1), CSK(4), CYFIP1(7), CYFIP2(6), DIAPH1(7), DIAPH2(2), DIAPH3(7), DOCK1(3), EGF(5), EGFR(9), EZR(2), F2(3), F2R(2), FGD1(2), FGD3(1), FGF1(2), FGF10(2), FGF11(1), FGF12(1), FGF13(1), FGF14(1), FGF19(2), FGF20(1), FGF21(1), FGF3(4), FGF6(4), FGF7(2), FGFR1(6), FGFR2(4), FGFR3(7), FGFR4(3), FN1(8), GIT1(3), GNA12(1), GNA13(4), GNG12(1), GSN(5), HRAS(1), INS(1), IQGAP1(5), IQGAP2(7), IQGAP3(6), ITGA1(8), ITGA10(4), ITGA11(6), ITGA2(4), ITGA2B(1), ITGA3(6), ITGA4(3), ITGA5(5), ITGA6(6), ITGA7(6), ITGA8(3), ITGA9(3), ITGAD(12), ITGAE(6), ITGAL(7), ITGAM(9), ITGAV(1), ITGAX(8), ITGB1(7), ITGB2(2), ITGB3(3), ITGB4(7), ITGB5(6), ITGB6(2), ITGB7(4), ITGB8(1), KRAS(3), LIMK2(4), MAP2K2(1), MAPK3(3), MOS(1), MRAS(1), MSN(3), MYH10(3), MYH14(8), MYH9(3), MYL2(1), MYL7(2), MYL9(1), MYLK(4), MYLK2(1), NCKAP1(2), NCKAP1L(5), NRAS(2), PAK1(3), PAK2(4), PAK3(1), PAK4(3), PAK6(5), PAK7(3), PDGFRA(6), PDGFRB(3), PFN3(1), PFN4(1), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PIP4K2A(4), PIP4K2B(2), PIP4K2C(3), PIP5K1A(2), PIP5K1B(1), PIP5K1C(4), PPP1CA(1), PPP1CC(2), PPP1R12A(3), PPP1R12B(2), PTK2(3), PXN(3), RAC2(1), RAC3(1), RAF1(4), RDX(2), ROCK1(5), ROCK2(3), SCIN(3), SLC9A1(3), SOS1(8), SOS2(7), SSH1(2), SSH2(12), SSH3(2), TIAM1(9), TIAM2(1), VAV1(4), VAV2(4), VAV3(1), VCL(2), WAS(1), WASF1(1), WASF2(2)	272707918	558	337	542	141	57	68	78	208	143	4	0.0986	1.000	1.000
418	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	134	ACTG1(4), CHAD(3), COL11A1(9), COL11A2(5), COL17A1(5), COL1A1(6), COL1A2(10), COL2A1(6), COL3A1(3), COL4A1(3), COL4A2(2), COL4A4(4), COL4A6(7), COL5A1(8), COL5A2(6), COL5A3(12), COL6A1(3), COL6A2(7), COL6A3(20), COL6A6(17), DES(1), DSC2(4), DSC3(3), DSG1(4), DSG2(3), DSG3(3), DSG4(5), FN1(8), GJA10(3), GJA3(2), GJA5(5), GJA8(1), GJA9(1), GJB1(2), GJB3(2), GJB5(1), GJB6(2), GJC1(3), GJC2(1), GJD2(1), IBSP(1), ITGA6(6), ITGB4(7), KRT1(3), KRT10(2), KRT12(2), KRT13(6), KRT15(2), KRT16(1), KRT17(4), KRT18(1), KRT19(2), KRT2(5), KRT20(1), KRT23(3), KRT24(1), KRT25(1), KRT27(4), KRT28(2), KRT3(2), KRT31(1), KRT32(1), KRT33A(1), KRT33B(2), KRT34(1), KRT35(2), KRT36(2), KRT37(1), KRT38(2), KRT39(1), KRT4(6), KRT40(2), KRT5(3), KRT6A(3), KRT6B(3), KRT6C(1), KRT7(1), KRT71(2), KRT72(2), KRT73(2), KRT74(2), KRT75(4), KRT76(4), KRT77(4), KRT78(3), KRT79(4), KRT81(1), KRT82(2), KRT83(2), KRT84(4), KRT85(6), KRT86(2), KRT9(2), LAMA1(11), LAMA2(9), LAMA3(10), LAMA4(9), LAMA5(9), LAMB1(16), LAMB2(7), LAMB3(4), LAMB4(5), LAMC1(5), LAMC2(6), LAMC3(8), LMNB1(3), LMNB2(1), NES(6), PRPH(3), RELN(7), SPP1(3), THBS2(3), THBS3(5), THBS4(2), TNC(13), TNN(2), TNR(9), TNXB(11), VIM(2), VTN(1), VWF(15)	240606104	515	315	506	174	62	70	52	179	150	2	0.884	1.000	1.000
419	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	234	ADCYAP1R1(2), ADORA2A(5), ADORA2B(1), ADORA3(2), ADRA1A(4), ADRA2B(1), ADRB2(2), AGTR1(2), AGTR2(1), AVPR1A(1), AVPR2(3), BDKRB1(1), BDKRB2(1), BRS3(2), C3AR1(3), C5AR1(3), CALCR(3), CALCRL(2), CCKAR(4), CCKBR(3), CGA(1), CHRM1(2), CHRM2(6), CHRM3(3), CHRM5(2), CNR1(1), CNR2(3), CRHR1(2), CRHR2(3), CYSLTR1(1), DRD1(1), DRD2(1), DRD3(3), DRD5(4), EDNRB(3), F2(3), F2R(2), F2RL1(1), F2RL2(2), F2RL3(1), FPR1(2), FSHR(2), GABBR1(5), GABRA1(3), GABRA2(1), GABRA3(1), GABRA4(1), GABRA5(1), GABRA6(1), GABRB1(2), GABRB2(3), GABRB3(2), GABRD(2), GABRE(4), GABRG1(3), GABRG2(5), GABRG3(3), GABRQ(8), GABRR1(2), GALR1(1), GH2(1), GHR(1), GIPR(2), GLP1R(3), GLP2R(3), GLRA1(3), GLRA2(2), GLRB(1), GPR156(1), GPR35(3), GPR50(3), GPR63(1), GPR83(2), GRIA1(8), GRIA2(4), GRIA3(2), GRIA4(4), GRID1(4), GRID2(9), GRIK1(3), GRIK2(4), GRIK3(6), GRIK5(5), GRIN1(2), GRIN2A(8), GRIN2B(8), GRIN2D(2), GRIN3A(2), GRIN3B(5), GRM1(4), GRM2(5), GRM3(5), GRM4(6), GRM5(8), GRM6(2), GRM7(5), GRM8(3), GRPR(2), HCRTR1(2), HCRTR2(4), HRH2(1), HRH3(2), HRH4(1), HTR1A(2), HTR1B(1), HTR1D(2), HTR1E(3), HTR1F(2), HTR2A(1), HTR2B(1), HTR2C(1), HTR4(2), HTR6(2), HTR7(2), LEP(1), LEPR(5), LTB4R2(1), MAS1(1), MC1R(2), MC2R(2), MC3R(2), MC4R(1), MC5R(1), MCHR1(1), MCHR2(2), MLNR(1), MTNR1B(1), NMUR2(6), NPBWR1(2), NPBWR2(1), NPFFR2(3), NPY1R(1), NPY2R(2), NR3C1(4), NTSR1(3), OPRD1(3), OPRK1(2), OPRL1(1), OPRM1(3), OXTR(1), P2RX1(3), P2RX2(4), P2RX3(3), P2RX5(1), P2RX7(2), P2RY1(3), P2RY10(1), P2RY11(1), P2RY13(1), P2RY14(1), P2RY2(2), P2RY4(1), P2RY6(2), P2RY8(2), PARD3(6), PRLR(3), PRSS1(6), PRSS3(9), PTAFR(1), PTGDR(1), PTGER2(1), PTGER4(1), PTGFR(5), PTGIR(2), RXFP1(1), RXFP2(3), SCTR(1), SSTR1(3), SSTR2(2), SSTR3(2), SSTR4(3), TAAR2(2), TACR1(1), TACR2(1), TACR3(2), TBXA2R(4), THRA(1), TRHR(2), TRPV1(2), TSHR(2), TSPO(1), UTS2R(2), VIPR1(1), VIPR2(2)	214927195	467	298	455	148	73	62	70	172	90	0	0.360	1.000	1.000
420	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	84	AGRN(10), CD36(1), CD44(3), CHAD(3), COL11A1(9), COL11A2(5), COL1A1(6), COL1A2(10), COL2A1(6), COL3A1(3), COL4A1(3), COL4A2(2), COL4A4(4), COL4A6(7), COL5A1(8), COL5A2(6), COL5A3(12), COL6A1(3), COL6A2(7), COL6A3(20), COL6A6(17), DAG1(3), FN1(8), FNDC1(3), FNDC3A(3), FNDC5(1), GP9(1), HMMR(1), HSPG2(13), IBSP(1), ITGA1(8), ITGA10(4), ITGA11(6), ITGA2(4), ITGA2B(1), ITGA3(6), ITGA4(3), ITGA5(5), ITGA6(6), ITGA7(6), ITGA8(3), ITGA9(3), ITGAV(1), ITGB1(7), ITGB3(3), ITGB4(7), ITGB5(6), ITGB6(2), ITGB7(4), ITGB8(1), LAMA1(11), LAMA2(9), LAMA3(10), LAMA4(9), LAMA5(9), LAMB1(16), LAMB2(7), LAMB3(4), LAMB4(5), LAMC1(5), LAMC2(6), LAMC3(8), RELN(7), SDC1(1), SDC2(1), SDC3(1), SDC4(1), SPP1(3), SV2A(1), SV2B(3), SV2C(2), THBS2(3), THBS3(5), THBS4(2), TNC(13), TNN(2), TNR(9), TNXB(11), VTN(1), VWF(15)	218343637	445	292	435	131	48	58	51	149	136	3	0.481	1.000	1.000
421	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(2), ADCY2(7), ADCY3(6), ADCY4(3), ADCY5(7), ADCY6(2), ADCY7(1), ADCY8(12), ADCY9(7), ADRA1A(4), ADRB2(2), ANXA6(3), ARRB1(3), ARRB2(1), ATP1A4(4), ATP1B1(5), ATP2A2(7), ATP2A3(5), ATP2B1(4), ATP2B3(2), CACNA1A(14), CACNA1B(5), CACNA1C(17), CACNA1D(9), CACNA1E(3), CACNA1S(14), CACNB1(4), CALM2(1), CALR(2), CAMK1(3), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(3), CASQ1(4), CASQ2(2), CHRM1(2), CHRM2(6), CHRM3(3), CHRM5(2), GJA5(5), GJB1(2), GJB3(2), GJB5(1), GJB6(2), GNA11(1), GNAI2(2), GNAI3(1), GNAO1(1), GNAZ(3), GNB1(3), GNB3(2), GNB5(2), GNG12(1), GNG3(1), GNG7(1), GRK4(2), GRK5(2), GRK6(5), ITPR1(7), ITPR2(12), ITPR3(5), KCNB1(2), KCNJ3(4), MIB1(1), MYCBP(1), NME7(2), PKIA(1), PLCB3(3), PRKACA(2), PRKACB(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PRKCA(2), PRKCD(5), PRKCE(4), PRKCG(6), PRKCH(4), PRKCQ(5), PRKCZ(1), PRKD1(4), RGS1(1), RGS11(1), RGS14(1), RGS16(2), RGS17(2), RGS18(2), RGS2(2), RGS20(1), RGS3(5), RGS6(3), RGS7(1), RGS9(5), RYR1(23), RYR2(17), RYR3(18), SFN(1), SLC8A1(3), SLC8A3(4), USP5(4), YWHAB(1)	189765843	401	272	390	123	73	49	37	135	107	0	0.380	1.000	1.000
422	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	124	ABL1(8), ABLIM1(5), ABLIM2(2), ABLIM3(3), ARHGEF12(5), CDC42(1), CFL1(1), CFL2(1), CXCR4(1), DCC(7), DPYSL2(3), EFNA1(2), EFNA3(1), EFNB1(1), EFNB2(1), EPHA1(4), EPHA2(1), EPHA3(5), EPHA4(2), EPHA5(5), EPHA6(4), EPHA7(2), EPHA8(5), EPHB1(4), EPHB2(2), EPHB4(6), EPHB6(7), FES(4), FYN(2), GNAI1(2), GNAI2(2), GNAI3(1), GSK3B(3), HRAS(1), ITGB1(7), KRAS(3), L1CAM(5), LIMK2(4), LRRC4C(2), MAPK3(3), NCK1(1), NCK2(2), NFAT5(8), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), NGEF(1), NRAS(2), NRP1(2), NTN4(2), NTNG1(3), PAK1(3), PAK2(4), PAK3(1), PAK4(3), PAK6(5), PAK7(3), PLXNA1(4), PLXNA2(10), PLXNA3(5), PLXNB1(9), PLXNB2(6), PLXNB3(4), PLXNC1(4), PPP3CA(3), PPP3CC(3), PTK2(3), RAC2(1), RAC3(1), RASA1(7), RGS3(5), RND1(2), ROBO1(5), ROBO2(9), ROBO3(4), ROCK1(5), ROCK2(3), SEMA3A(4), SEMA3C(2), SEMA3D(3), SEMA3E(3), SEMA3F(2), SEMA3G(1), SEMA4A(1), SEMA4B(1), SEMA4C(1), SEMA4D(2), SEMA4F(7), SEMA4G(5), SEMA5A(7), SEMA5B(2), SEMA6A(3), SEMA6B(2), SEMA6C(4), SEMA6D(3), SEMA7A(1), SLIT1(3), SLIT2(9), SLIT3(7), SRGAP1(10), SRGAP2(1), SRGAP3(4), UNC5A(4), UNC5B(5), UNC5C(3), UNC5D(2)	188813216	385	255	366	104	41	44	45	140	113	2	0.363	1.000	1.000
423	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	127	ACTG1(4), ACTN1(1), ACTN2(3), ACTN4(3), AKT1(2), AKT2(5), AKT3(3), AMOTL1(4), ASH1L(7), CASK(2), CDC42(1), CDK4(6), CGN(4), CLDN10(2), CLDN11(1), CLDN15(1), CLDN16(2), CLDN18(2), CLDN2(1), CLDN23(1), CLDN4(2), CLDN6(1), CLDN7(1), CSNK2A1(3), CSNK2A2(2), CSNK2B(1), CTNNA1(7), CTNNA2(7), CTNNA3(3), CTNNB1(2), EPB41(2), EPB41L1(4), EPB41L2(1), EPB41L3(7), EXOC4(3), F11R(1), GNAI1(2), GNAI2(2), GNAI3(1), HCLS1(1), HRAS(1), IGSF5(5), INADL(10), JAM3(2), KRAS(3), LLGL1(5), LLGL2(2), MAGI1(4), MAGI2(6), MAGI3(4), MLLT4(11), MPDZ(4), MPP5(1), MRAS(1), MYH1(5), MYH10(3), MYH11(10), MYH13(6), MYH14(8), MYH15(5), MYH2(9), MYH3(6), MYH4(15), MYH6(7), MYH7(13), MYH7B(6), MYH8(6), MYH9(3), MYL2(1), MYL7(2), MYL9(1), NRAS(2), OCLN(3), PARD3(6), PPM1J(3), PPP2CA(1), PPP2CB(2), PPP2R1A(2), PPP2R1B(2), PPP2R2A(6), PPP2R2B(3), PPP2R2C(3), PPP2R3A(1), PPP2R3B(1), PPP2R4(1), PRKCA(2), PRKCD(5), PRKCE(4), PRKCG(6), PRKCH(4), PRKCI(5), PRKCQ(5), PRKCZ(1), RAB13(1), RAB3B(1), SPTAN1(12), SRC(3), SYMPK(1), TJAP1(4), TJP1(6), TJP2(4), TJP3(1), YES1(2), ZAK(4)	191203220	380	253	364	122	37	46	41	122	132	2	0.927	1.000	1.000
424	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	129	ALCAM(3), CADM1(3), CADM3(3), CD2(2), CD22(4), CD276(2), CD28(1), CD34(2), CD40(1), CD58(1), CD6(3), CD80(1), CD86(3), CD8A(1), CD99(1), CDH1(2), CDH15(1), CDH2(7), CDH3(3), CDH4(5), CDH5(4), CLDN10(2), CLDN11(1), CLDN15(1), CLDN16(2), CLDN18(2), CLDN2(1), CLDN23(1), CLDN4(2), CLDN6(1), CLDN7(1), CNTN1(7), CNTN2(3), CNTNAP1(9), CNTNAP2(5), CTLA4(3), ESAM(3), F11R(1), GLG1(5), HLA-A(6), HLA-B(10), HLA-C(11), HLA-DOA(1), HLA-DPA1(1), HLA-DPB1(3), HLA-DQA1(3), HLA-DQA2(3), HLA-DQB1(3), HLA-DRA(1), HLA-DRB1(6), HLA-DRB5(8), HLA-E(2), HLA-F(1), ICAM1(3), ICOS(3), ICOSLG(1), ITGA4(3), ITGA6(6), ITGA8(3), ITGA9(3), ITGAL(7), ITGAM(9), ITGAV(1), ITGB1(7), ITGB2(2), ITGB7(4), ITGB8(1), JAM3(2), L1CAM(5), MADCAM1(3), MAG(1), MPZL1(2), NCAM1(2), NCAM2(5), NEGR1(2), NEO1(5), NFASC(8), NRCAM(4), NRXN1(10), NRXN2(5), NRXN3(4), OCLN(3), PDCD1(1), PTPRC(8), PTPRF(8), PTPRM(9), PVRL1(1), PVRL2(6), PVRL3(4), SDC1(1), SDC2(1), SDC3(1), SDC4(1), SELE(5), SELL(2), SELP(2), SELPLG(3), SIGLEC1(4), SPN(1), VCAM1(6), VCAN(15)	143069901	355	247	349	115	34	43	48	144	86	0	0.741	1.000	1.000
425	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	247	ACVR1(1), ACVR1B(3), ACVR2A(4), ACVR2B(1), BMP2(1), BMP7(5), BMPR1A(1), BMPR1B(2), BMPR2(5), CCL2(1), CCL27(2), CCL3(1), CCR2(2), CCR3(2), CCR5(1), CCR6(1), CCR7(1), CCR9(1), CD27(3), CD40(1), CLCF1(1), CNTF(1), CSF1R(6), CSF2RA(3), CSF2RB(5), CSF3R(3), CX3CL1(2), CX3CR1(1), CXCL1(1), CXCL11(1), CXCL13(1), CXCL5(1), CXCL9(1), CXCR4(1), CXCR6(1), EDA(2), EDA2R(1), EGF(5), EGFR(9), EPOR(3), FAS(2), FASLG(2), FLT1(8), FLT3(6), FLT4(14), GDF5(5), GH2(1), GHR(1), HGF(1), IFNA1(1), IFNA14(1), IFNA16(2), IFNA2(1), IFNA21(3), IFNA5(1), IFNA7(3), IFNA8(2), IFNAR1(3), IFNB1(2), IFNGR1(3), IFNGR2(2), IFNK(1), IL10RA(4), IL11RA(2), IL12RB1(4), IL12RB2(2), IL13RA1(2), IL15(1), IL15RA(2), IL17RA(1), IL17RB(4), IL18R1(1), IL18RAP(4), IL19(2), IL1B(1), IL1R1(3), IL1R2(8), IL1RAP(4), IL20RA(1), IL21(1), IL21R(5), IL22RA1(3), IL22RA2(1), IL23A(1), IL23R(4), IL25(2), IL26(1), IL2RA(2), IL2RB(2), IL3(1), IL4(1), IL4R(4), IL5RA(2), IL6R(2), IL6ST(6), IL7R(1), IL9(1), IL9R(6), INHBA(2), INHBB(2), INHBC(1), INHBE(1), KDR(6), KITLG(2), LEP(1), LEPR(5), LIFR(5), LTA(1), LTB(1), LTBR(2), NGFR(1), OSM(2), OSMR(1), PDGFC(1), PDGFRA(6), PDGFRB(3), PF4(1), PLEKHO2(1), PRLR(3), RELT(1), TGFB2(2), TGFBR1(1), TGFBR2(2), TNF(1), TNFRSF10B(1), TNFRSF10C(2), TNFRSF11B(1), TNFRSF13B(1), TNFRSF19(2), TNFRSF1A(1), TNFRSF1B(1), TNFRSF21(4), TNFRSF25(1), TNFRSF4(1), TNFRSF9(1), TNFSF13(1), TNFSF14(1), TNFSF15(2), TNFSF8(1), TNFSF9(1), TPO(4), VEGFA(1), VEGFC(2), XCL1(2), XCR1(1)	171207094	332	246	325	63	35	46	42	126	83	0	0.000793	1.000	1.000
426	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ACTA1(1), ACTA2(1), ADCY1(2), ADCY2(7), ADCY3(6), ADCY4(3), ADCY5(7), ADCY6(2), ADCY7(1), ADCY8(12), ADCY9(7), ARRB1(3), ARRB2(1), ATF1(2), ATF2(2), ATF3(1), ATF4(2), ATF5(1), ATP2A2(7), ATP2A3(5), CALCA(1), CALM2(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CNN2(3), CORIN(2), CRHR1(2), DGKZ(5), ETS2(1), FOS(1), GABPA(2), GABPB2(1), GBA2(4), GNB1(3), GNB3(2), GNB5(2), GNG12(1), GNG3(1), GNG7(1), GRK4(2), GRK5(2), GRK6(5), GSTO1(1), GUCA2A(1), GUCA2B(1), GUCY1A3(3), IGFBP1(1), IGFBP2(2), IGFBP3(1), IGFBP4(2), IGFBP6(3), IL1B(1), ITPR1(7), ITPR2(12), ITPR3(5), JUN(2), MIB1(1), MYL2(1), MYLK2(1), NFKB1(2), NOS1(10), NOS3(3), OXTR(1), PDE4B(1), PDE4D(1), PKIA(1), PLCB3(3), PLCD1(3), PLCG1(4), PLCG2(4), PRKACA(2), PRKACB(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PRKCA(2), PRKCD(5), PRKCE(4), PRKCH(4), PRKCQ(5), PRKCZ(1), PRKD1(4), RAMP1(1), RAMP2(1), RAMP3(1), RGS1(1), RGS11(1), RGS14(1), RGS16(2), RGS17(2), RGS18(2), RGS2(2), RGS20(1), RGS3(5), RGS6(3), RGS7(1), RGS9(5), RLN1(1), RYR1(23), RYR2(17), RYR3(18), SFN(1), SLC8A1(3), SP1(2), TNXB(11), USP5(4), YWHAB(1)	172236472	343	245	336	93	54	48	32	117	92	0	0.216	1.000	1.000
427	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	126	ACACA(9), ACACB(5), AKT1(2), AKT2(5), AKT3(3), ARAF(1), BAD(1), BRAF(4), CALM2(1), CBL(3), CBLB(4), CBLC(2), CRKL(1), EIF4EBP1(1), ELK1(1), EXOC7(6), FASN(9), FLOT2(1), FOXO1(4), G6PC(3), GCK(2), GRB2(2), GSK3B(3), GYS1(3), GYS2(3), HRAS(1), IKBKB(3), INPP5D(2), INS(1), IRS1(5), IRS4(1), KRAS(3), LIPE(6), MAP2K2(1), MAPK10(2), MAPK3(3), MAPK9(2), MKNK1(2), MKNK2(1), NRAS(2), PCK1(5), PCK2(2), PDE3A(3), PDE3B(3), PFKL(3), PFKM(3), PFKP(3), PHKA1(10), PHKA2(5), PHKB(4), PHKG1(3), PHKG2(1), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PKLR(1), PPARGC1A(4), PPP1CA(1), PPP1CC(2), PPP1R3A(4), PPP1R3B(1), PPP1R3C(1), PPP1R3D(1), PRKAA1(1), PRKAB1(1), PRKACA(2), PRKACB(2), PRKACG(2), PRKAG1(5), PRKAG2(6), PRKAG3(1), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PRKCI(5), PRKCZ(1), PRKX(2), PTPN1(2), PTPRF(8), PYGB(3), PYGL(2), PYGM(4), RAF1(4), RAPGEF1(5), RHOQ(1), RPS6KB1(2), RPS6KB2(2), SH2B2(2), SHC1(4), SHC2(4), SHC3(1), SHC4(1), SLC2A4(2), SOCS3(1), SOCS4(1), SORBS1(3), SOS1(8), SOS2(7), SREBF1(4), TRIP10(2), TSC1(5), TSC2(12)	151448136	321	241	314	71	34	51	43	116	73	4	0.00636	1.000	1.000
428	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	143	APC(9), APC2(5), AXIN1(4), AXIN2(1), BTRC(2), CACYBP(4), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CCND2(1), CHD8(6), CREBBP(9), CSNK1A1(2), CSNK1E(3), CSNK2A1(3), CSNK2A2(2), CSNK2B(1), CTBP1(2), CTBP2(1), CTNNB1(2), CUL1(5), CXXC4(2), DAAM1(5), DAAM2(1), DVL1(1), DVL2(1), EP300(16), FBXW11(2), FZD1(3), FZD10(4), FZD2(2), FZD3(1), FZD4(4), FZD5(2), FZD7(1), GSK3B(3), JUN(2), LEF1(3), LRP5(6), LRP6(8), MAP3K7(3), MAPK10(2), MAPK9(2), MYC(1), NFAT5(8), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), NKD1(4), NKD2(4), NLK(1), PLCB1(3), PLCB2(4), PLCB3(3), PLCB4(5), PORCN(2), PPARD(1), PPP2CA(1), PPP2CB(2), PPP2R1A(2), PPP2R1B(2), PPP2R2A(6), PPP2R2B(3), PPP2R2C(3), PPP3CA(3), PPP3CC(3), PRICKLE1(4), PRICKLE2(2), PRKACA(2), PRKACB(2), PRKACG(2), PRKCA(2), PRKCG(6), PRKX(2), RAC2(1), RAC3(1), RBX1(1), ROCK1(5), ROCK2(3), SENP2(1), SFRP2(1), SFRP4(2), SFRP5(3), SMAD2(2), SMAD3(2), SMAD4(3), TBL1X(3), TBL1XR1(5), TCF7L1(2), TCF7L2(1), VANGL1(5), VANGL2(3), WIF1(5), WNT1(2), WNT10A(3), WNT10B(1), WNT11(1), WNT2(2), WNT2B(2), WNT3(3), WNT3A(1), WNT5B(2), WNT7B(1), WNT8A(3), WNT8B(1), WNT9B(1)	157230717	318	231	306	80	32	33	46	108	98	1	0.182	1.000	1.000
429	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	149	AKT1(2), AKT2(5), AKT3(3), CBL(3), CBLB(4), CBLC(2), CCND2(1), CISH(2), CLCF1(1), CNTF(1), CREBBP(9), CSF2RA(3), CSF2RB(5), CSF3R(3), EP300(16), EPOR(3), GH2(1), GHR(1), GRB2(2), IFNA1(1), IFNA14(1), IFNA16(2), IFNA2(1), IFNA21(3), IFNA5(1), IFNA7(3), IFNA8(2), IFNAR1(3), IFNB1(2), IFNGR1(3), IFNGR2(2), IFNK(1), IL10RA(4), IL11RA(2), IL12RB1(4), IL12RB2(2), IL13RA1(2), IL15(1), IL15RA(2), IL19(2), IL20RA(1), IL21(1), IL21R(5), IL22RA1(3), IL22RA2(1), IL23A(1), IL23R(4), IL26(1), IL2RA(2), IL2RB(2), IL3(1), IL4(1), IL4R(4), IL5RA(2), IL6R(2), IL6ST(6), IL7R(1), IL9(1), IL9R(6), IRF9(2), JAK1(6), JAK2(7), JAK3(4), LEP(1), LEPR(5), LIFR(5), MYC(1), OSM(2), OSMR(1), PIAS1(5), PIAS2(3), PIAS3(3), PIAS4(1), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PRLR(3), PTPN11(2), PTPN6(3), SOCS3(1), SOCS4(1), SOCS5(2), SOCS7(2), SOS1(8), SOS2(7), SPRED1(6), SPRED2(2), SPRY1(1), SPRY2(3), STAM(6), STAT1(5), STAT2(7), STAT3(3), STAT4(2), STAT5A(3), STAT5B(3), STAT6(5), TPO(4), TYK2(7)	141745004	311	221	302	72	26	39	54	108	84	0	0.0626	1.000	1.000
430	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(2), AKT3(3), BCAR1(6), CAPN1(2), CAPN10(2), CAPN11(5), CAPN2(4), CAPN3(8), CAPN5(2), CAPN6(2), CAPN7(4), CAPN9(3), CAV2(2), CAV3(1), CDC42(1), CSK(4), DOCK1(3), FYN(2), GIT2(4), GRB2(2), ILK(4), ITGA10(4), ITGA11(6), ITGA2(4), ITGA2B(1), ITGA3(6), ITGA4(3), ITGA5(5), ITGA6(6), ITGA7(6), ITGA8(3), ITGA9(3), ITGAD(12), ITGAE(6), ITGAL(7), ITGAM(9), ITGAV(1), ITGAX(8), ITGB1(7), ITGB2(2), ITGB3(3), ITGB4(7), ITGB5(6), ITGB6(2), ITGB7(4), ITGB8(1), MAP2K2(1), MAP2K3(3), MAPK10(2), MAPK12(1), MAPK4(2), MAPK6(1), MAPK7(4), MYLK2(1), PAK1(3), PAK2(4), PAK3(1), PAK4(3), PAK6(5), PIK3R2(3), PTK2(3), PXN(3), RAC2(1), RAC3(1), RAPGEF1(5), RHO(1), ROCK1(5), ROCK2(3), SDCCAG8(1), SEPP1(2), SHC1(4), SHC3(1), SORBS1(3), SOS1(8), SRC(3), TLN1(13), TNS1(9), VAV2(4), VAV3(1), VCL(2), ZYX(1)	134851201	296	220	285	86	22	44	40	106	82	2	0.457	1.000	1.000
431	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	141	ADA(2), ADCY1(2), ADCY2(7), ADCY3(6), ADCY4(3), ADCY5(7), ADCY6(2), ADCY7(1), ADCY8(12), ADCY9(7), ADK(1), ADSL(3), ADSSL1(2), AK2(3), AK5(2), AK7(3), ALLC(3), AMPD1(2), AMPD2(5), AMPD3(4), ATIC(2), CANT1(1), DCK(1), ENPP1(4), ENPP3(2), ENTPD1(1), ENTPD2(1), ENTPD5(3), ENTPD6(2), GART(4), GDA(3), GMPR(2), GMPS(1), GUCY1A2(1), GUCY1A3(3), GUCY1B3(3), GUCY2C(5), GUCY2D(4), GUCY2F(6), HPRT1(1), IMPDH1(1), NME7(2), NPR1(4), NPR2(5), NT5C1A(2), NT5C1B(2), NT5C2(1), NT5M(2), NUDT5(4), NUDT9(1), PAPSS1(2), PAPSS2(4), PDE10A(1), PDE11A(7), PDE1A(1), PDE1C(2), PDE2A(3), PDE3B(3), PDE4A(2), PDE4B(1), PDE4C(7), PDE4D(1), PDE5A(5), PDE7A(1), PDE7B(1), PDE8A(2), PDE8B(2), PFAS(3), PKLR(1), PNPT1(2), POLA1(4), POLD1(7), POLD3(1), POLE(5), POLE2(1), POLR1A(6), POLR1B(4), POLR1C(2), POLR1D(1), POLR2A(13), POLR2B(7), POLR2F(4), POLR2I(1), POLR2J(1), POLR3A(5), POLR3B(5), POLR3G(1), POLR3H(1), POLR3K(1), PPAT(3), PRIM1(3), PRIM2(4), PRPS1(1), PRPS1L1(2), PRPS2(4), PRUNE(3), RFC5(3), RRM1(2), RRM2(1), XDH(6)	162727812	304	217	297	69	30	44	34	116	80	0	0.0506	1.000	1.000
432	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	92	ADCY1(2), ADCY2(7), ADCY3(6), ADCY4(3), ADCY5(7), ADCY6(2), ADCY7(1), ADCY8(12), ADCY9(7), DRD1(1), DRD2(1), EGF(5), EGFR(9), GJD2(1), GNA11(1), GNAI1(2), GNAI2(2), GNAI3(1), GNAS(6), GRB2(2), GRM1(4), GRM5(8), GUCY1A2(1), GUCY1A3(3), GUCY1B3(3), GUCY2C(5), GUCY2D(4), GUCY2F(6), HRAS(1), HTR2A(1), HTR2B(1), HTR2C(1), ITPR1(7), ITPR2(12), ITPR3(5), KRAS(3), MAP2K2(1), MAP2K5(3), MAP3K2(2), MAPK3(3), MAPK7(4), NPR1(4), NPR2(5), NRAS(2), PDGFC(1), PDGFD(4), PDGFRA(6), PDGFRB(3), PLCB1(3), PLCB2(4), PLCB3(3), PLCB4(5), PRKACA(2), PRKACB(2), PRKACG(2), PRKCA(2), PRKCG(6), PRKG1(4), PRKG2(3), PRKX(2), RAF1(4), SOS1(8), SOS2(7), SRC(3), TJP1(6), TUBA1A(2), TUBA3C(1), TUBA3D(2), TUBA4A(6), TUBAL3(3), TUBB(3), TUBB1(3), TUBB2B(2), TUBB8(4)	131344298	273	200	267	85	34	44	27	105	63	0	0.674	1.000	1.000
433	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	95	ADCY1(2), ADCY2(7), ADCY3(6), ADCY4(3), ADCY5(7), ADCY6(2), ADCY7(1), ADCY8(12), ADCY9(7), ATF4(2), CACNA1C(17), CACNA1D(9), CACNA1F(4), CACNA1S(14), CALM2(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CDC42(1), CGA(1), EGFR(9), ELK1(1), GNA11(1), GNAS(6), GRB2(2), HRAS(1), ITPR1(7), ITPR2(12), ITPR3(5), JUN(2), KRAS(3), MAP2K2(1), MAP2K3(3), MAP2K7(1), MAP3K1(7), MAP3K2(2), MAP3K3(2), MAP3K4(7), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(3), MAPK7(4), MAPK9(2), MMP14(1), MMP2(6), NRAS(2), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(4), PLCB1(3), PLCB2(4), PLCB3(3), PLCB4(5), PLD1(2), PLD2(5), PRKACA(2), PRKACB(2), PRKACG(2), PRKCA(2), PRKCD(5), PRKX(2), PTK2B(3), RAF1(4), SOS1(8), SOS2(7), SRC(3)	128842288	268	197	260	88	37	45	29	98	59	0	0.621	1.000	1.000
434	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	109	ADA(2), ADCY1(2), ADCY2(7), ADCY3(6), ADCY4(3), ADCY5(7), ADCY6(2), ADCY7(1), ADCY8(12), ADK(1), ADSL(3), AK2(3), AK5(2), ALLC(3), AMPD1(2), AMPD2(5), AMPD3(4), ATIC(2), ATP1B1(5), ATP5A1(3), ATP5B(3), ATP5C1(1), ATP5F1(1), ATP5G2(1), CANT1(1), DCK(1), ENPP1(4), ENPP3(2), ENTPD1(1), ENTPD2(1), GART(4), GDA(3), GMPS(1), GUCY1A2(1), GUCY1A3(3), GUCY1B3(3), GUCY2C(5), GUCY2D(4), GUCY2F(6), HPRT1(1), IMPDH1(1), NPR1(4), NPR2(5), NT5M(2), PAPSS1(2), PAPSS2(4), PDE1A(1), PDE4A(2), PDE4B(1), PDE4C(7), PDE4D(1), PDE5A(5), PDE6B(6), PDE6C(3), PDE7B(1), PDE8A(2), PFAS(3), PKLR(1), POLB(2), POLD1(7), POLE(5), POLG(6), POLL(2), POLQ(14), POLR1B(4), POLR2A(13), POLR2B(7), POLR2F(4), POLR2I(1), POLR2J(1), POLRMT(5), PPAT(3), PRPS1(1), PRPS1L1(2), PRPS2(4), PRUNE(3), RRM1(2), RRM2(1)	126537800	260	197	255	52	30	34	30	94	72	0	0.0134	1.000	1.000
435	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	124	ARAF(1), BID(2), BRAF(4), CD48(1), FAS(2), FASLG(2), FCER1G(1), FYN(2), GRB2(2), HCST(1), HLA-A(6), HLA-B(10), HLA-C(11), HLA-E(2), HRAS(1), ICAM1(3), IFNA1(1), IFNA14(1), IFNA16(2), IFNA2(1), IFNA21(3), IFNA5(1), IFNA7(3), IFNA8(2), IFNAR1(3), IFNB1(2), IFNGR1(3), IFNGR2(2), ITGAL(7), ITGB2(2), KIR2DL3(1), KIR3DL1(3), KIR3DL2(1), KLRC1(3), KLRC2(3), KLRC3(2), KLRK1(3), KRAS(3), LCK(1), LCP2(3), MAP2K2(1), MAPK3(3), MICA(1), MICB(4), NCR1(1), NCR2(1), NFAT5(8), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), NRAS(2), PAK1(3), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PLCG1(4), PLCG2(4), PPP3CA(3), PPP3CC(3), PRF1(1), PRKCA(2), PRKCG(6), PTK2B(3), PTPN11(2), PTPN6(3), RAC2(1), RAC3(1), RAF1(4), SH2D1B(1), SH3BP2(6), SHC1(4), SHC2(4), SHC3(1), SHC4(1), SOS1(8), SOS2(7), SYK(2), TNF(1), TNFRSF10B(1), TNFRSF10C(2), ULBP1(2), ULBP2(1), VAV1(4), VAV2(4), VAV3(1), ZAP70(1)	108727093	264	192	258	62	23	40	33	100	66	2	0.123	1.000	1.000
436	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	ARAF(1), BRAF(4), CACNA1A(14), CRHR1(2), GNA11(1), GNA12(1), GNA13(4), GNAI1(2), GNAI2(2), GNAI3(1), GNAO1(1), GNAS(6), GNAZ(3), GRIA1(8), GRIA2(4), GRIA3(2), GRID2(9), GRM1(4), GRM5(8), GUCY1A2(1), GUCY1A3(3), GUCY1B3(3), GUCY2C(5), GUCY2D(4), GUCY2F(6), HRAS(1), IGF1R(3), ITPR1(7), ITPR2(12), ITPR3(5), KRAS(3), LYN(1), MAP2K2(1), MAPK3(3), NOS1(10), NOS3(3), NPR1(4), NPR2(5), NRAS(2), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(4), PLCB1(3), PLCB2(4), PLCB3(3), PLCB4(5), PPP2CA(1), PPP2CB(2), PPP2R1A(2), PPP2R1B(2), PPP2R2A(6), PPP2R2B(3), PPP2R2C(3), PRKCA(2), PRKCG(6), PRKG1(4), PRKG2(3), RAF1(4), RYR1(23)	110431542	244	187	241	67	42	26	24	91	60	1	0.296	1.000	1.000
437	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	71	ACP1(1), ACTG1(4), ACTN1(1), ACTN2(3), ACTN4(3), ACVR1B(3), ACVR1C(3), BAIAP2(2), CDC42(1), CDH1(2), CREBBP(9), CSNK2A1(3), CSNK2A2(2), CSNK2B(1), CTNNA1(7), CTNNA2(7), CTNNA3(3), CTNNB1(2), CTNND1(5), EGFR(9), EP300(16), ERBB2(8), FARP2(3), FER(2), FGFR1(6), FYN(2), IGF1R(3), IQGAP1(5), LEF1(3), LMO7(11), MAP3K7(3), MAPK3(3), MLLT4(11), NLK(1), PARD3(6), PTPN1(2), PTPN6(3), PTPRB(5), PTPRF(8), PTPRJ(12), PTPRM(9), PVRL1(1), PVRL2(6), PVRL3(4), RAC2(1), RAC3(1), SMAD2(2), SMAD3(2), SMAD4(3), SNAI1(1), SNAI2(3), SORBS1(3), SRC(3), SSX2IP(3), TCF7L1(2), TCF7L2(1), TGFBR1(1), TGFBR2(2), TJP1(6), VCL(2), WAS(1), WASF1(1), WASF2(2), WASF3(2), YES1(2)	112608926	248	185	233	67	27	26	36	83	74	2	0.386	1.000	1.000
438	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	161	ADORA2A(5), ADORA2B(1), ADORA3(2), ADRA1A(4), ADRB2(2), AGTR1(2), AGTR2(1), AVPR1A(1), AVPR2(3), BDKRB1(1), BDKRB2(1), BRS3(2), C3AR1(3), CCKAR(4), CCKBR(3), CCR2(2), CCR3(2), CCR5(1), CCR6(1), CCR7(1), CCR9(1), CCRL2(1), CHML(1), CHRM1(2), CHRM2(6), CHRM3(3), CHRM5(2), CMKLR1(1), CNR1(1), CNR2(3), CX3CR1(1), CXCR4(1), DRD1(1), DRD2(1), DRD3(3), DRD5(4), EDNRB(3), F2R(2), F2RL1(1), F2RL2(2), F2RL3(1), FPR1(2), FSHR(2), GALR1(1), GALT(3), GPR17(2), GPR173(2), GPR174(4), GPR27(1), GPR3(1), GPR35(3), GPR37(3), GPR37L1(2), GPR4(1), GPR50(3), GPR63(1), GPR83(2), GPR85(3), GPR87(3), GRPR(2), HCRTR1(2), HCRTR2(4), HRH2(1), HRH3(2), HTR1A(2), HTR1B(1), HTR1D(2), HTR1E(3), HTR1F(2), HTR2A(1), HTR2B(1), HTR2C(1), HTR4(2), HTR6(2), HTR7(2), MAS1(1), MC1R(2), MC3R(2), MC4R(1), MC5R(1), MLNR(1), MTNR1B(1), NMUR2(6), NPY1R(1), NPY2R(2), NTSR1(3), OPN1SW(2), OPRD1(3), OPRK1(2), OPRL1(1), OPRM1(3), OR11A1(1), OR12D3(1), OR1C1(1), OR1F1(2), OR1Q1(1), OR7A5(2), OR7C1(2), OR8B8(2), OXTR(1), P2RY1(3), P2RY10(1), P2RY11(1), P2RY12(1), P2RY13(1), P2RY14(1), P2RY2(2), P2RY6(2), PTAFR(1), PTGDR(1), PTGER2(1), PTGER4(1), PTGFR(5), PTGIR(2), RHO(1), SSTR1(3), SSTR2(2), SSTR3(2), SSTR4(3), SUCNR1(1), TBXA2R(4), TRHR(2)	115278121	238	184	236	81	40	30	31	97	40	0	0.492	1.000	1.000
439	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	79	AGL(7), AMY2A(1), AMY2B(2), ASCC3(6), ATP13A2(7), DDX18(3), DDX23(3), DDX4(5), DDX41(3), DDX47(2), DDX50(9), DDX51(1), DDX52(2), DDX54(3), DDX55(3), DDX56(2), DHX58(3), ENPP1(4), ENPP3(2), ENTPD7(3), EP400(14), ERCC2(1), ERCC3(4), G6PC(3), GAA(3), GANC(3), GBA(3), GBE1(1), GCK(2), GUSB(5), GYS1(3), GYS2(3), HK1(6), IFIH1(3), MGAM(8), MOV10L1(6), NUDT5(4), PGM1(1), PYGB(3), PYGL(2), PYGM(4), RAD54B(1), RAD54L(2), RUVBL2(3), SETX(10), SI(9), SKIV2L2(2), SMARCA2(5), SMARCA5(4), UGDH(1), UGP2(1), UGT1A1(5), UGT1A3(1), UGT1A4(2), UGT1A5(2), UGT1A6(3), UGT1A7(3), UGT1A9(5), UGT2A1(3), UGT2A3(3), UGT2B11(2), UGT2B15(1), UGT2B17(1), UGT2B28(5), UGT2B4(4), UGT2B7(6), UXS1(1)	122997694	238	181	234	76	18	28	42	85	64	1	0.780	1.000	1.000
440	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(1), ACTA2(1), ACTN2(3), ACTN4(3), DES(1), DMD(14), MYBPC1(5), MYBPC2(3), MYBPC3(2), MYH3(6), MYH6(7), MYH7(13), MYH8(6), MYL1(4), MYL2(1), MYL9(1), MYOM1(6), NEB(22), TCAP(1), TMOD1(6), TNNI1(2), TNNT1(2), TNNT2(1), TNNT3(1), TPM2(1), TPM3(1), TPM4(1), TTN(111), VIM(2)	140734031	228	180	222	69	20	37	27	90	50	4	0.555	1.000	1.000
441	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	106	ABL1(8), ANAPC1(4), ANAPC10(1), ANAPC2(2), ANAPC4(6), ANAPC5(3), ANAPC7(2), ATM(19), ATR(12), BUB1(2), BUB1B(1), BUB3(1), CCNA1(7), CCNB1(1), CCNB2(6), CCNB3(4), CCND2(1), CCNE1(2), CCNE2(4), CCNH(1), CDC14A(5), CDC14B(1), CDC16(4), CDC20(3), CDC23(2), CDC25A(1), CDC25B(1), CDC25C(3), CDC6(2), CDC7(2), CDK2(2), CDK4(6), CDK6(1), CDKN1A(3), CDKN1B(1), CDKN2C(1), CHEK1(1), CHEK2(2), CREBBP(9), CUL1(5), E2F1(1), E2F2(1), E2F3(1), EP300(16), ESPL1(12), FZR1(3), GADD45B(1), GSK3B(3), HDAC1(2), MAD1L1(1), MAD2L1(1), MCM2(10), MCM3(1), MCM4(1), MCM5(3), MCM6(5), MCM7(6), PCNA(3), PKMYT1(1), PLK1(1), PRKDC(12), RB1(4), RBL2(5), RBX1(1), SFN(1), SKP2(1), SMAD2(2), SMAD3(2), SMAD4(3), SMC1A(4), SMC1B(4), TGFB2(2), WEE1(2), YWHAB(1)	133986462	259	178	244	66	21	29	38	82	85	4	0.219	1.000	1.000
442	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	109	ACTN1(1), ACTN2(3), ACTN4(3), ARHGAP5(6), BCAR1(6), CD99(1), CDC42(1), CDH5(4), CLDN10(2), CLDN11(1), CLDN15(1), CLDN16(2), CLDN18(2), CLDN2(1), CLDN23(1), CLDN4(2), CLDN6(1), CLDN7(1), CTNNA1(7), CTNNA2(7), CTNNA3(3), CTNNB1(2), CTNND1(5), CXCR4(1), ESAM(3), EZR(2), F11R(1), GNAI1(2), GNAI2(2), GNAI3(1), ICAM1(3), ITGA4(3), ITGAL(7), ITGAM(9), ITGB1(7), ITGB2(2), ITK(1), JAM3(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(1), MLLT4(11), MMP2(6), MMP9(1), MSN(3), MYL2(1), MYL7(2), MYL9(1), NCF1(1), NCF2(1), NOX1(7), NOX3(6), OCLN(3), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PLCG1(4), PLCG2(4), PRKCA(2), PRKCG(6), PTK2(3), PTK2B(3), PTPN11(2), PXN(3), RAC2(1), RAP1A(1), RAPGEF3(2), RAPGEF4(2), ROCK1(5), ROCK2(3), SIPA1(4), TXK(1), VAV1(4), VAV2(4), VAV3(1), VCAM1(6), VCL(2)	121982234	242	177	234	71	30	29	30	88	64	1	0.616	1.000	1.000
443	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY1(2), ADCY2(7), ADCY3(6), ADCY4(3), ADCY5(7), ADCY6(2), ADCY7(1), ADCY8(12), ADCY9(7), AKAP1(3), AKAP10(2), AKAP11(3), AKAP12(7), AKAP2(2), AKAP3(3), AKAP4(2), AKAP5(1), AKAP6(5), AKAP7(1), AKAP8(2), AKAP9(21), ARHGEF1(2), CALM2(1), CHMP1B(2), GNA11(1), GNA12(1), GNA13(4), GNA15(1), GNAI2(2), GNAI3(1), GNAO1(1), GNAZ(3), GNB1(3), GNB3(2), GNB5(2), GNG10(1), GNG12(1), GNG3(1), GNG7(1), HRAS(1), IL18BP(1), ITPR1(7), KCNJ3(4), KRAS(3), NRAS(2), PALM2(1), PDE1A(1), PDE1B(5), PDE1C(2), PDE4A(2), PDE4B(1), PDE4C(7), PDE4D(1), PDE7A(1), PDE7B(1), PDE8A(2), PDE8B(2), PLCB3(3), PPP3CA(3), PPP3CC(3), PRKACA(2), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PRKCA(2), PRKCD(5), PRKCE(4), PRKCG(6), PRKCH(4), PRKCI(5), PRKCQ(5), PRKCZ(1), PRKD1(4), PRKD3(4), SLC9A1(3), USP5(4)	117000085	241	175	234	69	24	36	14	91	75	1	0.550	1.000	1.000
444	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	80	ACVR1(1), ACVR1B(3), ACVRL1(1), AKT1(2), AURKB(1), BMPR1A(1), BMPR2(5), BUB1(2), CDKL1(1), CDKL2(4), CDS2(2), CLK1(5), CLK2(2), CLK4(5), COL4A3BP(3), CSNK2A1(3), CSNK2A2(2), CSNK2B(1), DGKA(4), DGKB(3), DGKD(3), DGKE(5), DGKG(5), DGKH(6), DGKQ(3), DGKZ(5), IMPA1(1), INPP4A(2), INPP4B(4), INPP5A(1), INPPL1(4), ITPKA(1), ITPKB(3), MAP3K10(4), MOS(1), NEK1(3), NEK3(3), OCRL(3), PAK4(3), PIK3C2A(6), PIK3C2B(5), PIK3C2G(4), PIK3CB(5), PIK3CG(4), PLCB1(3), PLCB2(4), PLCB3(3), PLCB4(5), PLCD1(3), PLCG1(4), PLCG2(4), PLK3(2), PRKACA(2), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PRKCA(2), PRKCD(5), PRKCE(4), PRKCG(6), PRKCH(4), PRKCQ(5), PRKCZ(1), PRKD1(4), PRKG1(4), RAF1(4), RPS6KA3(3), RPS6KA4(2), RPS6KB1(2), STK11(2), TGFBR1(1), VRK1(1)	110028100	225	171	223	51	22	32	20	76	75	0	0.0876	1.000	1.000
445	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	84	ABL1(8), ABL2(5), AKT1(2), AKT2(5), AKT3(3), ARAF(1), AREG(1), BAD(1), BRAF(4), BTC(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CBL(3), CBLB(4), CBLC(2), CDKN1A(3), CDKN1B(1), CRKL(1), EGF(5), EGFR(9), EIF4EBP1(1), ELK1(1), ERBB2(8), ERBB3(6), ERBB4(10), GAB1(2), GRB2(2), GSK3B(3), HRAS(1), JUN(2), KRAS(3), MAP2K2(1), MAP2K7(1), MAPK10(2), MAPK3(3), MAPK9(2), MYC(1), NCK1(1), NCK2(2), NRAS(2), NRG1(3), NRG2(3), NRG3(5), PAK1(3), PAK2(4), PAK3(1), PAK4(3), PAK6(5), PAK7(3), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PLCG1(4), PLCG2(4), PRKCA(2), PRKCG(6), PTK2(3), RAF1(4), RPS6KB1(2), RPS6KB2(2), SHC1(4), SHC2(4), SHC3(1), SHC4(1), SOS1(8), SOS2(7), SRC(3), STAT5A(3), STAT5B(3), TGFA(1)	100063974	233	170	224	50	22	32	38	85	54	2	0.0341	1.000	1.000
446	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	71	CALM2(1), CDS2(2), DGKA(4), DGKB(3), DGKD(3), DGKE(5), DGKG(5), DGKH(6), DGKI(1), DGKQ(3), DGKZ(5), FN3K(1), IMPA1(1), IMPA2(3), INPP4A(2), INPP4B(4), INPP5A(1), INPP5B(5), INPP5D(2), INPP5E(2), INPPL1(4), ITPK1(2), ITPKA(1), ITPKB(3), ITPR1(7), ITPR2(12), ITPR3(5), OCRL(3), PI4KA(10), PI4KB(3), PIK3C2A(6), PIK3C2B(5), PIK3C2G(4), PIK3C3(4), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PIP4K2A(4), PIP4K2B(2), PIP4K2C(3), PIP5K1A(2), PIP5K1B(1), PIP5K1C(4), PLCB1(3), PLCB2(4), PLCB3(3), PLCB4(5), PLCD1(3), PLCD3(1), PLCD4(3), PLCE1(6), PLCG1(4), PLCG2(4), PLCZ1(3), PRKCA(2), PRKCG(6), PTPMT1(1), SYNJ1(6), SYNJ2(5)	122610042	226	168	220	69	25	36	23	78	63	1	0.614	1.000	1.000
447	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	43	ABCA1(9), ABCA10(6), ABCA12(14), ABCA13(22), ABCA2(3), ABCA3(4), ABCA4(11), ABCA5(8), ABCA6(5), ABCA7(11), ABCA8(6), ABCA9(3), ABCB1(4), ABCB10(1), ABCB11(4), ABCB4(8), ABCB5(5), ABCB6(3), ABCB7(1), ABCB8(1), ABCB9(2), ABCC10(7), ABCC11(7), ABCC12(3), ABCC2(4), ABCC3(8), ABCC4(7), ABCC5(5), ABCC6(7), ABCC8(5), ABCC9(4), ABCD1(3), ABCD2(2), ABCD3(2), ABCD4(4), ABCG1(1), ABCG2(2), ABCG4(7), ABCG5(3), ABCG8(5), CFTR(8), TAP1(1), TAP2(1)	115209665	227	167	219	70	15	34	33	92	52	1	0.516	1.000	1.000
448	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	91	AKT1(2), AKT2(5), AKT3(3), BCL10(1), CARD11(10), CBL(3), CBLB(4), CBLC(2), CD28(1), CD3E(1), CD3G(2), CD8A(1), CDC42(1), CDK4(6), CHUK(2), CTLA4(3), FOS(1), FYN(2), GRAP2(1), GRB2(2), HRAS(1), ICOS(3), IKBKB(3), IL4(1), ITK(1), JUN(2), KRAS(3), LCK(1), LCP2(3), MALT1(2), MAP3K8(1), NCK1(1), NCK2(2), NFAT5(8), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), NFKB1(2), NFKB2(3), NFKBIA(2), NFKBIB(2), NRAS(2), PAK1(3), PAK2(4), PAK3(1), PAK4(3), PAK6(5), PAK7(3), PDCD1(1), PDK1(1), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PLCG1(4), PPP3CA(3), PPP3CC(3), PRKCQ(5), PTPN6(3), PTPRC(8), RASGRP1(3), SOS1(8), SOS2(7), TEC(5), TNF(1), VAV1(4), VAV2(4), VAV3(1), ZAP70(1)	97655632	222	166	212	38	20	27	31	87	57	0	0.00461	1.000	1.000
449	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	99	ADCY1(2), ADCY2(7), ADCY3(6), ADCY4(3), ADCY5(7), ADCY6(2), ADCY7(1), ADCY8(12), ADCY9(7), ASIP(1), CALM2(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CREB3L1(1), CREB3L2(1), CREB3L3(1), CREB3L4(3), CREBBP(9), CTNNB1(2), DCT(4), DVL1(1), DVL2(1), EDNRB(3), EP300(16), FZD1(3), FZD10(4), FZD2(2), FZD3(1), FZD4(4), FZD5(2), FZD7(1), GNAI1(2), GNAI2(2), GNAI3(1), GNAO1(1), GNAS(6), GSK3B(3), HRAS(1), KITLG(2), KRAS(3), LEF1(3), MAP2K2(1), MAPK3(3), MC1R(2), MITF(5), NRAS(2), PLCB1(3), PLCB2(4), PLCB3(3), PLCB4(5), POMC(2), PRKACA(2), PRKACB(2), PRKACG(2), PRKCA(2), PRKCG(6), PRKX(2), RAF1(4), TCF7L1(2), TCF7L2(1), TYR(5), TYRP1(4), WNT1(2), WNT10A(3), WNT10B(1), WNT11(1), WNT2(2), WNT2B(2), WNT3(3), WNT3A(1), WNT5B(2), WNT7B(1), WNT8A(3), WNT8B(1), WNT9B(1)	106042160	222	166	214	58	28	27	25	87	55	0	0.185	1.000	1.000
450	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	75	ABL1(8), ACTN1(1), ACTR2(2), AKT1(2), AKT2(5), AKT3(3), ARHGEF6(4), ARHGEF7(5), BCAR1(6), BRAF(4), CDC42(1), CSE1L(4), DOCK1(3), EPHB2(2), FYN(2), GRB2(2), GRB7(5), ILK(4), ITGA1(8), ITGA10(4), ITGA11(6), ITGA2(4), ITGA3(6), ITGA4(3), ITGA5(5), ITGA6(6), ITGA7(6), ITGA8(3), ITGA9(3), ITGB3BP(1), MAP2K7(1), MAP3K11(1), MAPK10(2), MAPK8IP1(4), MAPK8IP2(1), MAPK8IP3(2), MAPK9(2), MRAS(1), MYLK(4), MYLK2(1), P4HB(3), PAK1(3), PAK2(4), PAK3(1), PAK4(3), PAK6(5), PAK7(3), PIK3CB(5), PKLR(1), PLCG1(4), PLCG2(4), PTK2(3), RAF1(4), RALA(2), RHO(1), ROCK1(5), ROCK2(3), SHC1(4), SOS1(8), SOS2(7), SRC(3), TLN1(13), TLN2(11), WAS(1), ZYX(1)	118716011	239	165	232	68	16	34	33	88	65	3	0.526	1.000	1.000
451	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CD2BP2(1), CDC40(3), CLK2(2), CLK3(2), CLK4(5), COL2A1(6), CPSF1(4), CPSF2(2), CPSF3(5), CPSF4(2), CSTF2T(2), CSTF3(4), DDX1(1), DDX20(7), DHX15(2), DHX16(3), DHX38(3), DHX8(3), DHX9(6), DICER1(5), FUS(5), GIPC1(3), METTL3(4), NONO(2), NUDT21(1), NXF1(1), PAPOLA(3), PHF5A(1), POLR2A(13), PPM1G(2), PRPF18(2), PRPF3(2), PRPF4B(7), PRPF8(14), PSKH1(1), PTBP1(1), PTBP2(1), RBM17(3), RBM5(2), RNMT(4), RNPS1(1), SF3A1(2), SF3A3(1), SF3B1(16), SF3B2(5), SF3B4(1), SNRPA(1), SNRPB(2), SNRPB2(1), SNRPE(1), SNRPN(2), SPOP(1), SRPK2(2), SRRM1(5), SUPT5H(7), TXNL4A(1), U2AF2(3), XRN2(3)	105751759	195	162	190	43	19	39	19	69	48	1	0.0766	1.000	1.000
452	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	65	A2M(8), BDKRB1(1), BDKRB2(1), C1QA(1), C1QC(1), C1R(4), C2(4), C3(8), C3AR1(3), C4BPA(3), C4BPB(3), C5(6), C5AR1(3), C6(3), C7(4), C8A(1), C8B(1), C8G(2), CD46(1), CD55(2), CD59(1), CFB(3), CFH(5), CFI(2), CPB2(6), CR1(8), CR2(4), F10(1), F11(2), F12(7), F13A1(3), F13B(4), F2(3), F2R(2), F5(11), F7(1), F8(8), F9(2), FGA(4), FGB(3), FGG(6), KLKB1(2), KNG1(4), MASP1(4), MASP2(1), MBL2(2), PLAT(4), PLAUR(2), PLG(8), PROC(3), PROS1(5), SERPINA1(3), SERPIND1(3), SERPINF2(2), SERPING1(2), TFPI(2), THBD(1), VWF(15)	88615845	209	161	201	42	24	25	23	87	47	3	0.0153	1.000	1.000
453	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	105	A4GNT(3), ALG1(1), ALG10(3), ALG10B(8), ALG11(4), ALG12(2), ALG13(5), ALG14(1), ALG3(3), ALG6(3), ALG8(1), ALG9(2), B3GNT1(2), B3GNT2(3), B3GNT6(4), B3GNT7(1), B4GALT1(1), B4GALT3(2), B4GALT4(2), B4GALT5(2), CHPF(1), CHST1(2), CHST11(1), CHST12(2), CHST14(1), CHST2(2), CHST3(2), CHST4(1), CHST6(2), CHST7(2), EXT1(3), EXT2(1), EXTL1(1), EXTL3(3), FUT11(4), GALNT1(1), GALNT10(7), GALNT11(3), GALNT13(3), GALNT14(3), GALNT2(2), GALNT4(3), GALNT5(6), GALNT6(5), GALNT7(7), GALNT8(1), GALNT9(1), GALNTL5(3), GCNT1(2), GCNT3(2), GCNT4(3), HS2ST1(2), HS3ST2(2), HS3ST3A1(1), HS3ST5(1), HS6ST1(3), HS6ST2(3), HS6ST3(1), MAN1A1(2), MAN1A2(1), MAN1B1(1), MAN2A1(3), MGAT2(1), MGAT3(1), MGAT4A(3), MGAT4B(1), MGAT5(4), MGAT5B(4), NDST1(2), NDST2(4), NDST3(1), NDST4(7), OGT(5), RPN1(3), RPN2(1), ST3GAL1(2), ST3GAL3(3), ST3GAL4(2), ST6GAL1(1), ST6GALNAC1(2), STT3B(4), UST(1), WBSCR17(5), XYLT1(5), XYLT2(2)	104876799	217	159	210	66	21	32	26	69	69	0	0.667	1.000	1.000
454	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	66	ADCY1(2), ADCY8(12), ARAF(1), ATF4(2), BRAF(4), CACNA1C(17), CALM2(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(3), CREBBP(9), EP300(16), GRIA1(8), GRIA2(4), GRIN1(2), GRIN2A(8), GRIN2B(8), GRIN2D(2), GRM1(4), GRM5(8), HRAS(1), ITPR1(7), ITPR2(12), ITPR3(5), KRAS(3), MAP2K2(1), MAPK3(3), NRAS(2), PLCB1(3), PLCB2(4), PLCB3(3), PLCB4(5), PPP1CA(1), PPP1CC(2), PPP1R12A(3), PPP1R1A(1), PPP3CA(3), PPP3CC(3), PRKACA(2), PRKACB(2), PRKACG(2), PRKCA(2), PRKCG(6), PRKX(2), RAF1(4), RAP1A(1), RAPGEF3(2), RPS6KA3(3), RPS6KA6(1)	99425787	205	156	196	56	26	30	23	74	51	1	0.247	1.000	1.000
455	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	85	ACVR1(1), ACVR1B(3), ACVR1C(3), ACVR2A(4), ACVR2B(1), ACVRL1(1), BMP2(1), BMP4(1), BMP5(1), BMP6(1), BMP7(5), BMP8B(1), BMPR1A(1), BMPR1B(2), BMPR2(5), CHRD(5), CREBBP(9), CUL1(5), DCN(3), E2F5(1), EP300(16), GDF5(5), GDF6(2), GDF7(1), INHBA(2), INHBB(2), INHBC(1), INHBE(1), LEFTY1(1), LEFTY2(1), LTBP1(8), MAPK3(3), MYC(1), NODAL(2), NOG(2), PITX2(2), PPP2CA(1), PPP2CB(2), PPP2R1A(2), PPP2R1B(2), PPP2R2A(6), PPP2R2B(3), PPP2R2C(3), RBL2(5), RBX1(1), ROCK1(5), ROCK2(3), RPS6KB1(2), RPS6KB2(2), SMAD1(1), SMAD2(2), SMAD3(2), SMAD4(3), SMAD5(1), SMAD6(1), SMAD7(1), SMAD9(1), SMURF1(1), SMURF2(3), SP1(2), TGFB2(2), TGFBR1(1), TGFBR2(2), THBS2(3), THBS3(5), THBS4(2), TNF(1), ZFYVE16(1), ZFYVE9(6)	93514179	182	146	178	43	21	17	31	60	53	0	0.108	1.000	1.000
456	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	83	ANPEP(8), CD19(1), CD1A(1), CD1B(1), CD1C(2), CD1D(2), CD1E(2), CD2(2), CD22(4), CD33(3), CD34(2), CD36(1), CD38(1), CD3E(1), CD3G(2), CD44(3), CD5(1), CD55(2), CD59(1), CD8A(1), CR1(8), CR2(4), CSF1R(6), CSF2RA(3), CSF3R(3), DNTT(4), EPOR(3), FCER2(1), FCGR1A(2), FLT3(6), GP9(1), HLA-DRA(1), HLA-DRB1(6), HLA-DRB5(8), IL11RA(2), IL1B(1), IL1R1(3), IL1R2(8), IL2RA(2), IL3(1), IL4(1), IL4R(4), IL5RA(2), IL6R(2), IL7R(1), IL9R(6), ITGA1(8), ITGA2(4), ITGA2B(1), ITGA3(6), ITGA4(3), ITGA5(5), ITGA6(6), ITGAM(9), ITGB3(3), KITLG(2), MME(5), MS4A1(1), TFRC(3), THPO(1), TNF(1), TPO(4)	80607770	192	146	182	40	15	17	27	68	64	1	0.138	1.000	1.000
457	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	90	BAD(1), CABIN1(11), CALM2(1), CAMK2B(1), CAMK4(3), CD3E(1), CD3G(2), CDKN1A(3), CNR1(1), CREBBP(9), CSNK2A1(3), CSNK2B(1), CTLA4(3), EGR2(1), EGR3(2), EP300(16), FOS(1), GATA3(2), GATA4(2), GSK3A(2), GSK3B(3), HRAS(1), ICOS(3), IFNA1(1), IFNB1(2), IL1B(1), IL2RA(2), IL3(1), IL4(1), ITK(1), JUNB(2), MAP2K7(1), MAPK14(1), MAPK9(2), MEF2A(2), MEF2D(1), NCK2(2), NFAT5(8), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), NFKB2(3), NFKBIB(2), NPPB(1), NUP214(8), OPRD1(3), P2RX7(2), PAK1(3), PPIA(1), PPP3CC(3), PTPRC(8), RELA(6), SFN(1), SLA(1), SP1(2), SP3(2), TNF(1), TRAF2(1), TRPV6(5), VAV1(4), VAV2(4), VAV3(1), XPO5(3)	88775783	188	143	177	47	19	20	28	60	59	2	0.327	1.000	1.000
458	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	80	ABL1(8), ATM(19), BUB1(2), BUB1B(1), BUB3(1), CCNA1(7), CCNB1(1), CCNB2(6), CCNB3(4), CCND2(1), CCNE1(2), CCNE2(4), CCNH(1), CDAN1(6), CDC14A(5), CDC14B(1), CDC20(3), CDC25A(1), CDC25B(1), CDC25C(3), CDC6(2), CDC7(2), CDH1(2), CDK2(2), CDK4(6), CDKN1A(3), CHEK1(1), CHEK2(2), DTX4(5), E2F1(1), E2F2(1), E2F3(1), E2F5(1), EP300(16), ESPL1(12), GSK3B(3), HDAC1(2), HDAC4(1), HDAC5(3), HDAC6(3), HDAC8(1), MAD1L1(1), MAD2L1(1), MCM2(10), MCM3(1), MCM4(1), MCM5(3), MCM6(5), MCM7(6), MPEG1(1), PCNA(3), PLK1(1), PRKDC(12), PTPRA(5), RB1(4), SKP2(1), SMAD4(3), TBC1D8(1), WEE1(2)	109835501	208	142	195	55	18	25	33	67	61	4	0.251	1.000	1.000
459	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	56	ASH1L(7), ASH2L(3), CTCFL(5), DOT1L(9), EED(1), EHMT1(4), EHMT2(8), EZH1(2), EZH2(4), FBXO11(5), HCFC1(8), HSF4(3), JMJD4(1), JMJD6(4), KDM6A(10), MEN1(1), NSD1(13), OGT(5), PAXIP1(4), PPP1CA(1), PPP1CC(2), PRDM2(4), PRDM6(1), PRDM7(3), PRDM9(8), PRMT5(3), PRMT6(2), PRMT7(2), PRMT8(3), RBBP5(5), SATB1(4), SETD1A(8), SETD1B(1), SETD7(1), SETDB1(6), SETMAR(2), SMYD3(2), SUV39H2(5), SUV420H1(3), SUZ12(6), WHSC1(5), WHSC1L1(5)	116505608	179	139	178	48	15	27	22	59	55	1	0.352	1.000	1.000
460	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	98	AKT1(2), AKT2(5), AKT3(3), CASP8(1), CCL3(1), CD40(1), CD80(1), CD86(3), CHUK(2), CXCL11(1), CXCL9(1), FOS(1), IFNA1(1), IFNA14(1), IFNA16(2), IFNA2(1), IFNA21(3), IFNA5(1), IFNA7(3), IFNA8(2), IFNAR1(3), IFNB1(2), IKBKB(3), IKBKE(3), IL1B(1), IRAK1(3), IRAK4(1), IRF5(3), IRF7(1), JUN(2), LBP(1), LY96(1), MAP2K2(1), MAP2K3(3), MAP2K7(1), MAP3K7(3), MAP3K8(1), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(3), MAPK9(2), NFKB1(2), NFKB2(3), NFKBIA(2), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), RELA(6), RIPK1(1), SPP1(3), STAT1(5), TBK1(3), TICAM1(3), TLR1(3), TLR2(2), TLR3(1), TLR4(3), TLR5(4), TLR6(2), TLR7(5), TLR8(5), TLR9(1), TNF(1), TRAF3(1), TRAF6(2)	86343029	161	133	156	37	17	19	21	73	29	2	0.153	1.000	1.000
461	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	68	ACACB(5), ACSL1(4), ACSL4(1), ACSL5(1), ACSL6(5), AKT1(2), AKT2(5), AKT3(3), CAMKK1(4), CAMKK2(3), CD36(1), CHUK(2), CPT1A(2), CPT1C(4), CPT2(2), G6PC(3), IKBKB(3), IRS1(5), IRS4(1), JAK1(6), JAK2(7), JAK3(4), LEP(1), LEPR(5), MAPK10(2), MAPK9(2), NFKB1(2), NFKB2(3), NFKBIA(2), NFKBIB(2), NPY(1), PCK1(5), PCK2(2), POMC(2), PPARGC1A(4), PRKAA1(1), PRKAB1(1), PRKAG1(5), PRKAG2(6), PRKAG3(1), PRKCQ(5), PTPN11(2), RELA(6), RXRB(4), RXRG(2), SLC2A1(2), SLC2A4(2), SOCS3(1), STAT3(3), STK11(2), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TRADD(2), TRAF2(1), TYK2(7)	78519789	162	132	156	42	14	22	29	49	47	1	0.354	1.000	1.000
462	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	83	ATF2(2), BRAF(4), CHUK(2), DAXX(6), ELK1(1), FOS(1), GRB2(2), HRAS(1), IKBKB(3), JUN(2), MAP2K2(1), MAP2K3(3), MAP2K5(3), MAP2K7(1), MAP3K1(7), MAP3K10(4), MAP3K11(1), MAP3K12(4), MAP3K13(2), MAP3K2(2), MAP3K3(2), MAP3K4(7), MAP3K5(5), MAP3K6(3), MAP3K7(3), MAP3K8(1), MAP3K9(5), MAP4K1(4), MAP4K3(6), MAP4K4(2), MAP4K5(4), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(3), MAPK4(2), MAPK6(1), MAPK7(4), MAPK9(2), MAPKAPK2(1), MAX(5), MEF2A(2), MEF2D(1), MKNK1(2), MKNK2(1), MYC(1), NFKB1(2), NFKBIA(2), PAK1(3), PAK2(4), RAF1(4), RELA(6), RIPK1(1), RPS6KA3(3), RPS6KA4(2), RPS6KA5(2), RPS6KB1(2), RPS6KB2(2), SHC1(4), SP1(2), STAT1(5), TGFB2(2), TGFBR1(1), TRADD(2), TRAF2(1)	94445350	175	130	169	42	18	18	19	64	53	3	0.326	1.000	1.000
463	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	62	AKT1(2), AKT2(5), AKT3(3), BCL10(1), BLNK(1), CARD11(10), CD19(1), CD22(4), CD72(1), CD81(1), CHUK(2), CR2(4), FOS(1), GSK3B(3), HRAS(1), IFITM1(1), IKBKB(3), INPP5D(2), JUN(2), KRAS(3), LILRB3(4), LYN(1), MALT1(2), NFAT5(8), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), NFKB1(2), NFKB2(3), NFKBIA(2), NFKBIB(2), NRAS(2), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PLCG2(4), PPP3CA(3), PPP3CC(3), PTPN6(3), RAC2(1), RAC3(1), RASGRP3(2), SYK(2), VAV1(4), VAV2(4), VAV3(1)	71797497	150	125	141	36	17	18	15	58	42	0	0.252	1.000	1.000
464	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	57	AKT1(2), AKT2(5), AKT3(3), BAD(1), CDC42(1), CDK2(2), CDKN1B(1), CREB5(3), ERBB4(10), F2RL2(2), GAB1(2), GRB2(2), GSK3A(2), GSK3B(3), IGFBP1(1), INPPL1(4), IRS1(5), IRS4(1), MYC(1), NOLC1(2), PAK1(3), PAK2(4), PAK3(1), PAK4(3), PAK6(5), PAK7(3), PARD3(6), PDK1(1), PIK3CD(2), PPP1R13B(4), PREX1(8), PTK2(3), PTPN1(2), RPS6KA3(3), RPS6KB1(2), SFN(1), SHC1(4), SLC2A4(2), SOS1(8), SOS2(7), TSC1(5), TSC2(12), YWHAB(1)	67270759	143	122	139	33	16	20	24	41	39	3	0.0868	1.000	1.000
465	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	68	AKT1(2), AKT2(5), AKT3(3), BAD(1), CASP9(2), CDC42(1), HRAS(1), KDR(6), KRAS(3), MAP2K2(1), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(3), MAPKAPK2(1), NFAT5(8), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), NOS3(3), NRAS(2), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(4), PLCG1(4), PLCG2(4), PPP3CA(3), PPP3CC(3), PRKCA(2), PRKCG(6), PTGS2(5), PTK2(3), PXN(3), RAC2(1), RAC3(1), RAF1(4), SH2D2A(3), SHC2(4), SPHK1(1), SPHK2(1), SRC(3), VEGFA(1)	68975748	152	121	147	43	14	20	20	60	38	0	0.516	1.000	1.000
466	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	42	ADAM17(2), APH1A(1), CREBBP(9), CTBP1(2), CTBP2(1), DLL1(1), DLL3(1), DLL4(2), DTX1(5), DTX3(1), DTX3L(2), DTX4(5), DVL1(1), DVL2(1), EP300(16), HDAC1(2), JAG1(9), JAG2(4), MAML1(9), MAML2(6), MAML3(8), NCOR2(6), NCSTN(2), NOTCH1(12), NOTCH2(14), NOTCH3(11), NOTCH4(6), NUMB(3), NUMBL(1), PSEN2(2), PSENEN(1), PTCRA(2), RBPJ(4), SNW1(3)	65175755	155	119	149	74	17	18	18	45	53	4	1.000	1.000	1.000
467	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	73	AKT1(2), AKT2(5), AKT3(3), FCER1G(1), FYN(2), GAB2(2), GRB2(2), HRAS(1), IL3(1), IL4(1), INPP5D(2), KRAS(3), LCP2(3), LYN(1), MAP2K2(1), MAP2K3(3), MAP2K7(1), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(3), MAPK9(2), MS4A2(1), NRAS(2), PDK1(1), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(4), PLCG1(4), PLCG2(4), PRKCA(2), PRKCD(5), PRKCE(4), RAC2(1), RAC3(1), RAF1(4), SOS1(8), SOS2(7), SYK(2), TNF(1), VAV1(4), VAV2(4), VAV3(1)	69832961	133	118	130	41	13	22	21	53	24	0	0.506	1.000	1.000
468	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	AICDA(3), CAD(12), CANT1(1), DCK(1), DCTD(1), DPYD(5), DPYS(4), DTYMK(1), ENTPD1(1), ENTPD5(3), ENTPD6(2), NME7(2), NT5C1A(2), NT5C1B(2), NT5C2(1), NT5M(2), PNPT1(2), POLA1(4), POLD1(7), POLD3(1), POLE(5), POLE2(1), POLR1A(6), POLR1B(4), POLR1C(2), POLR1D(1), POLR2A(13), POLR2B(7), POLR2F(4), POLR2I(1), POLR2J(1), POLR3A(5), POLR3B(5), POLR3G(1), POLR3H(1), POLR3K(1), PRIM1(3), PRIM2(4), RFC5(3), RRM1(2), RRM2(1), TK1(1), TK2(2), TXNRD1(2), TXNRD2(1), TYMS(1), UCK1(1), UCK2(1), UMPS(1), UPB1(1), UPP1(2), UPP2(2), UPRT(3)	81728932	146	116	137	34	12	23	17	48	44	2	0.159	1.000	1.000
469	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(3), ALPL(4), ALPP(5), ALPPL2(5), ASCC3(6), ATP13A2(7), DDX18(3), DDX23(3), DDX4(5), DDX41(3), DDX47(2), DDX50(9), DDX51(1), DDX52(2), DDX54(3), DDX55(3), DDX56(2), DHX58(3), ENTPD7(3), EP400(14), ERCC2(1), ERCC3(4), FPGS(3), GGH(2), IFIH1(3), MOV10L1(6), NUDT5(4), PTS(1), QDPR(1), RAD54B(1), RAD54L(2), RUVBL2(3), SETX(10), SKIV2L2(2), SMARCA2(5), SMARCA5(4)	62195910	138	116	135	41	10	23	26	46	32	1	0.372	1.000	1.000
470	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	45	AKT1(2), AKT2(5), AKT3(3), BAD(1), BCR(1), BLNK(1), CD19(1), CD22(4), CD81(1), CR2(4), CSK(4), DAG1(3), FLOT2(1), GRB2(2), GSK3A(2), GSK3B(3), INPP5D(2), ITPR1(7), ITPR2(12), ITPR3(5), LYN(1), MAP4K1(4), MAPK3(3), NFATC1(4), NFATC2(8), PDK1(1), PIK3CD(2), PIK3R1(5), PLCG2(4), PPP1R13B(4), PPP3CA(3), PPP3CC(3), PTPRC(8), RAF1(4), SHC1(4), SOS1(8), SOS2(7), SYK(2), VAV1(4)	70970293	143	115	137	32	16	19	23	44	41	0	0.109	1.000	1.000
471	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(8), ATP4A(6), ATP5A1(3), ATP5B(3), ATP5C1(1), ATP5E(1), ATP5F1(1), ATP5G2(1), ATP5L(1), ATP6AP1(4), ATP6V0A1(3), ATP6V0A2(2), ATP6V0A4(4), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(4), ATP6V1B2(4), ATP6V1D(1), ATP6V1G1(1), COX10(5), COX15(3), COX17(1), COX5A(1), COX6B2(1), COX7A1(2), COX8A(1), CYC1(1), NDUFA1(1), NDUFA10(1), NDUFA11(2), NDUFA13(2), NDUFA3(1), NDUFA6(1), NDUFB10(1), NDUFB11(1), NDUFB2(2), NDUFB4(1), NDUFB5(3), NDUFB6(1), NDUFB7(1), NDUFC1(2), NDUFS1(8), NDUFS2(1), NDUFS3(3), NDUFS5(1), NDUFS6(2), NDUFS7(1), NDUFS8(1), NDUFV1(2), NDUFV2(1), PPA2(2), SDHA(9), SDHB(1), SDHD(2), TCIRG1(2), UQCRC1(1), UQCRC2(2), UQCRFS1(2)	55948858	131	114	129	33	13	17	21	49	30	1	0.236	1.000	1.000
472	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	51	ADORA3(2), ALG6(3), CCKBR(3), CCR2(2), CCR3(2), CCR5(1), CELSR1(17), CELSR2(9), CELSR3(10), CHRM2(6), CHRM3(3), CIDEB(2), EMR2(4), EMR3(9), F2R(2), FSHR(2), GPR116(5), GPR133(7), GPR135(2), GPR143(1), GPR17(2), GPR18(2), GPR55(1), GPR56(1), GPR61(1), GPR84(3), GRM1(4), GRPR(2), HRH4(1), LGR6(2), LPHN2(4), LPHN3(9), LTB4R2(1), NTSR1(3), P2RY11(1), P2RY13(1), PTGFR(5), SMO(4), SSTR2(2), TSHR(2)	64070642	143	111	137	45	22	18	18	51	34	0	0.592	1.000	1.000
473	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	28	BRAF(4), CPEB1(3), EGFR(9), ERBB2(8), ERBB4(10), ETS1(2), ETS2(1), ETV6(2), FMN2(8), GRB2(2), KRAS(3), MAPK3(3), NOTCH1(12), NOTCH2(14), NOTCH3(11), NOTCH4(6), PIWIL1(2), PIWIL2(2), PIWIL3(4), PIWIL4(3), RAF1(4), SOS1(8), SOS2(7), SPIRE1(1), SPIRE2(2)	50297264	131	111	127	35	22	14	18	44	30	3	0.389	1.000	1.000
474	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	45	FN3K(1), IMPA1(1), IMPA2(3), INPP4A(2), INPP4B(4), INPP5A(1), INPP5B(5), INPP5E(2), INPPL1(4), IPMK(1), ITPK1(2), ITPKA(1), ITPKB(3), MINPP1(2), MIOX(2), OCRL(3), PI4KA(10), PI4KB(3), PIK3C3(4), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIP4K2A(4), PIP4K2B(2), PIP4K2C(3), PIP5K1A(2), PIP5K1B(1), PIP5K1C(4), PLCB1(3), PLCB2(4), PLCB3(3), PLCB4(5), PLCD1(3), PLCD3(1), PLCD4(3), PLCE1(6), PLCG1(4), PLCG2(4), PLCZ1(3), PTPMT1(1), SYNJ1(6), SYNJ2(5)	70947574	132	107	127	44	12	17	14	45	43	1	0.895	1.000	1.000
475	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	54	BMP2(1), BMP4(1), BMP5(1), BMP6(1), BMP7(5), BMP8B(1), BTRC(2), CSNK1A1(2), CSNK1E(3), CSNK1G2(1), CSNK1G3(1), FBXW11(2), GLI1(7), GLI2(4), GLI3(7), GSK3B(3), HHIP(3), IHH(1), LRP2(24), PRKACA(2), PRKACB(2), PRKACG(2), PRKX(2), PTCH1(10), PTCH2(2), SHH(3), SMO(4), STK36(2), SUFU(3), WNT1(2), WNT10A(3), WNT10B(1), WNT11(1), WNT2(2), WNT2B(2), WNT3(3), WNT3A(1), WNT5B(2), WNT7B(1), WNT8A(3), WNT8B(1), WNT9B(1), ZIC2(1)	57495139	126	107	118	38	18	17	13	45	33	0	0.650	1.000	1.000
476	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	46	ADCY4(3), ADCY6(2), ADCY8(12), CACNA1A(14), CACNA1B(5), GNAS(6), GNB1(3), GNB3(2), GNG3(1), GRM4(6), ITPR3(5), KCNB1(2), PDE1A(1), PLCB2(4), PRKACA(2), PRKACB(2), PRKACG(2), PRKX(2), SCNN1A(4), SCNN1B(4), SCNN1G(2), TAS1R1(2), TAS1R2(8), TAS1R3(3), TAS2R10(1), TAS2R13(2), TAS2R14(1), TAS2R38(3), TAS2R39(2), TAS2R4(2), TAS2R41(1), TAS2R42(1), TAS2R46(2), TAS2R50(2), TAS2R60(1), TAS2R8(1), TAS2R9(2), TRPM5(3)	55407578	121	107	120	34	32	15	13	37	24	0	0.197	1.000	1.000
477	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	65	ADAM10(4), ADAM17(2), ATP6AP1(4), ATP6V0A1(3), ATP6V0A2(2), ATP6V0A4(4), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(4), ATP6V1B2(4), ATP6V1D(1), ATP6V1G1(1), CDC42(1), CHUK(2), CSK(4), CXCL1(1), EGFR(9), F11R(1), GIT1(3), IGSF5(5), IKBKB(3), JAM3(2), JUN(2), LYN(1), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK9(2), NFKB1(2), NFKB2(3), NFKBIA(2), NOD1(3), PAK1(3), PLCG1(4), PLCG2(4), PTPN11(2), PTPRZ1(14), RELA(6), SRC(3), TCIRG1(2), TJP1(6)	67961641	132	106	123	35	14	16	15	53	32	2	0.513	1.000	1.000
478	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	65	ACAA1(3), ACADL(3), ACADM(1), ACOX1(2), ACOX2(2), ACOX3(5), ACSL1(4), ACSL4(1), ACSL5(1), ACSL6(5), ANGPTL4(3), APOA1(1), APOA5(2), CD36(1), CPT1A(2), CPT1C(4), CPT2(2), CYP27A1(1), CYP4A11(5), CYP4A22(1), CYP8B1(3), DBI(1), EHHADH(6), FABP1(3), FABP3(1), FADS2(2), GK(1), GK2(3), HMGCS2(1), ILK(4), LPL(3), ME1(1), MMP1(1), NR1H3(2), PCK1(5), PCK2(2), PLTP(2), PPARD(1), PPARG(2), RXRB(4), RXRG(2), SCP2(3), SLC27A1(4), SLC27A2(1), SLC27A5(3), SLC27A6(7), SORBS1(3), UBC(4), UCP1(1)	62411596	125	105	119	40	11	16	17	42	38	1	0.808	1.000	1.000
479	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	72	B2M(3), CALR(2), CANX(2), CD74(1), CD8A(1), CIITA(5), CTSB(4), CTSS(1), HLA-A(6), HLA-B(10), HLA-C(11), HLA-DOA(1), HLA-DPA1(1), HLA-DPB1(3), HLA-DQA1(3), HLA-DQA2(3), HLA-DQB1(3), HLA-DRA(1), HLA-DRB1(6), HLA-DRB5(8), HLA-E(2), HLA-F(1), HSP90AA1(6), HSP90AB1(7), HSPA5(2), IFI30(1), IFNA1(1), IFNA14(1), IFNA16(2), IFNA2(1), IFNA21(3), IFNA5(1), IFNA7(3), IFNA8(2), KIR2DL3(1), KIR3DL1(3), KIR3DL2(1), KIR3DL3(3), KLRC1(3), KLRC2(3), KLRC3(2), LTA(1), NFYA(1), NFYC(2), PSME2(3), RFX5(3), RFXAP(1), TAP1(1), TAP2(1)	42078792	137	105	135	43	7	20	17	60	31	2	0.795	1.000	1.000
480	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	91	ANK2(16), B3GALT4(1), CDR1(4), DGKI(1), IL6ST(6), PIGK(1), RPL10(1), RPL11(3), RPL13(1), RPL14(1), RPL18(3), RPL18A(2), RPL19(2), RPL21(1), RPL23(1), RPL24(1), RPL26(1), RPL27(1), RPL28(1), RPL3(3), RPL30(3), RPL31(1), RPL32(1), RPL34(1), RPL38(1), RPL3L(3), RPL4(2), RPL5(3), RPL6(1), RPL7(1), RPL7A(3), RPL8(1), RPLP0(1), RPS11(1), RPS13(1), RPS14(2), RPS19(1), RPS2(2), RPS21(2), RPS24(2), RPS26(1), RPS27(1), RPS27A(1), RPS29(1), RPS3(2), RPS3A(1), RPS4Y1(1), RPS6KA3(3), RPS6KA6(1), RPS6KB1(2), RPS6KB2(2), RPS7(1), RPS8(1), RPS9(1), RPSA(1), SLC36A2(1), TBC1D10C(2), TSPAN9(1), UBA52(1), UBB(1), UBC(4)	50008845	114	104	112	33	7	13	20	43	30	1	0.630	1.000	1.000
481	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	61	ATM(19), CCNA1(7), CCNB1(1), CCND2(1), CCNE1(2), CCNE2(4), CCNG2(2), CCNH(1), CDC25A(1), CDK2(2), CDK4(6), CDKN1A(3), CDKN1B(1), CDKN2C(1), CREB3L1(1), CREB3L3(1), CREB3L4(3), E2F1(1), E2F2(1), E2F3(1), E2F5(1), GBA2(4), MCM2(10), MCM3(1), MCM4(1), MCM5(3), MCM6(5), MCM7(6), MNAT1(1), MYC(1), MYT1(5), PCNA(3), POLE(5), POLE2(1), PRIM1(3), RB1(4), RPA1(2), RPA2(1), RPA3(1), TFDP2(5), TNXB(11), WEE1(2)	70391464	135	101	126	28	14	13	15	45	45	3	0.117	1.000	1.000
482	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	62	ACSS1(3), ACSS2(7), ADH1A(2), ADH1B(2), ADH4(2), ADH5(1), ADH6(2), ADHFE1(3), AKR1A1(2), ALDH1B1(4), ALDH2(4), ALDH3A2(2), ALDH3B1(4), ALDH3B2(3), ALDH7A1(1), ALDOA(2), ALDOB(3), ALDOC(1), DLAT(2), DLD(4), ENO1(5), ENO2(1), ENO3(2), G6PC(3), GALM(3), GAPDH(4), GAPDHS(5), GCK(2), HK1(6), LDHAL6B(1), LDHB(2), LDHC(3), PDHA1(1), PDHA2(3), PDHB(1), PFKL(3), PFKM(3), PFKP(3), PGAM2(2), PGK1(3), PGK2(1), PGM1(1), PKLR(1), TPI1(2)	55703935	115	100	109	29	11	9	19	35	39	2	0.335	1.000	1.000
483	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	ACTG1(4), APAF1(3), ARHGDIB(1), BAG4(1), BID(2), BIRC2(2), BIRC3(5), CASP2(1), CASP7(1), CASP8(1), CASP9(2), CFLAR(1), CHUK(2), DAXX(6), DFFA(1), DFFB(1), GSN(5), LMNB1(3), LMNB2(1), MAP2K7(1), MAP3K1(7), MAP3K5(5), NFKB1(2), NFKBIA(2), NUMA1(6), PAK2(4), PRKCD(5), PRKDC(12), PSEN2(2), PTK2(3), RASA1(7), RB1(4), RELA(6), RIPK1(1), SPTAN1(12), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TRADD(2), TRAF2(1)	69400667	128	98	125	36	5	23	18	37	42	3	0.465	1.000	1.000
484	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT1(2), AKT2(5), AKT3(3), ASAH1(2), BRAF(4), DAG1(3), DRD2(1), EGFR(9), EPHB2(2), GRB2(2), ITPKA(1), ITPKB(3), ITPR1(7), ITPR2(12), ITPR3(5), KCNJ3(4), PI3(1), PIK3CB(5), PITX2(2), PLCB1(3), PLCB2(4), PLCB3(3), PLCB4(5), RAF1(4), RGS20(1), SHC1(4), SOS1(8), SOS2(7), SRC(3), STAT3(3)	58297991	118	95	116	28	12	18	20	38	29	1	0.129	1.000	1.000
485	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(9), AXIN1(4), CCND2(1), CSNK1E(3), CTNNB1(2), DVL1(1), DVL2(1), FZD1(3), FZD10(4), FZD2(2), FZD3(1), FZD5(2), FZD7(1), GSK3B(3), JUN(2), LDLR(3), MAPK10(2), MAPK9(2), MYC(1), PAFAH1B1(1), PPP2R5C(3), PPP2R5E(1), PRKCA(2), PRKCD(5), PRKCE(4), PRKCG(6), PRKCH(4), PRKCI(5), PRKCQ(5), PRKCZ(1), PRKD1(4), SFRP4(2), WNT1(2), WNT10A(3), WNT10B(1), WNT11(1), WNT2(2), WNT2B(2), WNT3(3), WNT5B(2), WNT7B(1)	57268066	107	94	103	29	14	17	10	34	32	0	0.346	1.000	1.000
486	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	56	AADAT(2), ACAT1(1), ACMSD(2), ALDH1B1(4), ALDH2(4), ALDH3A2(2), ALDH7A1(1), AOC2(4), AOC3(2), AOX1(8), CAT(2), CYP1A1(1), CYP1A2(4), CYP1B1(2), DDC(3), ECHS1(3), EHHADH(6), HAAO(2), HADH(1), HADHA(4), HSD17B4(1), KYNU(3), LCMT1(1), LCMT2(4), LNX1(1), MAOA(2), MAOB(2), METTL2B(1), NFX1(3), OGDH(8), OGDHL(2), PRMT2(2), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(2), PRMT8(3), TPH1(2), TPH2(2), WARS(1), WARS2(1)	58383011	106	93	105	26	10	19	21	35	21	0	0.120	1.000	1.000
487	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	49	ACOX1(2), APOA1(1), CD36(1), CITED2(1), CREBBP(9), EHHADH(6), EP300(16), FABP1(3), HSD17B4(1), INS(1), JUN(2), LPL(3), MAPK3(3), ME1(1), MRPL11(1), MYC(1), NCOA1(3), NCOR1(7), NCOR2(6), NFKBIA(2), NR1H3(2), NR2F1(1), NRIP1(5), PIK3R1(5), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PRKCA(2), PTGS2(5), RB1(4), RELA(6), SP1(2), STAT5A(3), STAT5B(3), TNF(1)	60371809	119	93	110	47	7	14	13	40	42	3	0.984	1.000	1.000
488	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	68	ADH1A(2), ADH1B(2), ADH4(2), ADH5(1), ADH6(2), ADHFE1(3), AKR1C1(1), AKR1C2(1), AKR1C3(2), AKR1C4(1), ALDH3B1(4), ALDH3B2(3), CYP1A1(1), CYP1A2(4), CYP1B1(2), CYP2B6(1), CYP2C18(1), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP2E1(1), CYP2F1(4), CYP3A43(2), CYP3A5(1), CYP3A7(2), DHDH(5), GSTA1(1), GSTA2(1), GSTA3(1), GSTA4(1), GSTA5(1), GSTK1(1), GSTM1(2), GSTM2(1), GSTM4(1), GSTM5(1), GSTP1(2), GSTT1(2), UGT1A1(5), UGT1A3(1), UGT1A4(2), UGT1A5(2), UGT1A6(3), UGT1A7(3), UGT1A9(5), UGT2A1(3), UGT2A3(3), UGT2B11(2), UGT2B15(1), UGT2B17(1), UGT2B28(5), UGT2B4(4), UGT2B7(6)	55816845	112	92	110	30	15	10	15	43	29	0	0.426	1.000	1.000
489	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	57	BAK1(1), BFAR(1), CAD(12), CASP10(3), CASP8(1), CSNK1A1(2), DAXX(6), DEDD(2), DFFA(1), DIABLO(1), EGFR(9), EPHB2(2), FAF1(1), FAIM2(1), MAP2K7(1), MAP3K1(7), MAP3K5(5), MAPK10(2), MAPK8IP1(4), MAPK8IP2(1), MAPK8IP3(2), MAPK9(2), NFAT5(8), NFKB1(2), NFKB2(3), NFKBIA(2), NFKBIB(2), NFKBIL1(2), PTPN13(8), RALBP1(2), RIPK1(1), ROCK1(5), SMPD1(4), TPX2(2), TRAF2(1)	69095136	109	92	102	29	17	11	10	43	27	1	0.450	1.000	1.000
490	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	40	ACTR2(2), AKT1(2), AKT2(5), AKT3(3), ARHGAP1(1), ARHGEF11(5), CDC42(1), CFL1(1), CFL2(1), GDI2(2), INPPL1(4), ITPR1(7), ITPR2(12), ITPR3(5), MYLK(4), MYLK2(1), PAK1(3), PAK2(4), PAK3(1), PAK4(3), PAK6(5), PAK7(3), PDK1(1), PIK3CD(2), PIK3CG(4), PIK3R1(5), PITX2(2), PPP1R13B(4), RACGAP1(1), RHO(1), ROCK1(5), ROCK2(3), SAG(5), WASF1(1)	64986210	109	91	108	28	11	21	13	36	28	0	0.232	1.000	1.000
491	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	37	AKT1(2), ATF2(2), CDC42(1), DLD(4), DUSP10(1), DUSP4(1), DUSP8(1), GAB1(2), GCK(2), IL1R1(3), JUN(2), MAP2K5(3), MAP2K7(1), MAP3K1(7), MAP3K10(4), MAP3K11(1), MAP3K12(4), MAP3K13(2), MAP3K2(2), MAP3K3(2), MAP3K4(7), MAP3K5(5), MAP3K7(3), MAP3K9(5), MAPK10(2), MAPK7(4), MAPK9(2), MYEF2(1), NFATC3(7), NR2C2(1), PAPPA(4), SHC1(4), TRAF6(2), ZAK(4)	48939164	98	89	94	27	7	13	12	41	23	2	0.537	1.000	1.000
492	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	36	ANKHD1(13), EEF1A2(3), EEF1B2(3), EEF1D(1), EEF1G(2), EEF2(2), EEF2K(4), EIF1AX(1), EIF2AK1(4), EIF2AK2(4), EIF2AK3(2), EIF2B1(1), EIF2B2(1), EIF2B3(1), EIF2B4(1), EIF2B5(2), EIF2S2(2), EIF2S3(2), EIF4A1(1), EIF4A2(4), EIF4E(2), EIF4EBP1(1), EIF4G1(7), EIF4G3(7), EIF5(3), EIF5A(2), EIF5B(2), ETF1(2), GSPT2(1), PABPC3(17), PAIP1(3), SLC35A4(2)	42628211	103	88	99	33	11	19	16	35	21	1	0.551	1.000	1.000
493	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	44	AKT1(2), AKT2(5), AKT3(3), BRD4(4), CBL(3), CDC42(1), F2RL2(2), FLOT2(1), GRB2(2), GSK3A(2), GSK3B(3), IGFBP1(1), INPPL1(4), IRS1(5), IRS4(1), LNPEP(3), MAPK3(3), PARD3(6), PDK1(1), PIK3CD(2), PIK3R1(5), PTPN1(2), RAF1(4), RPS6KA3(3), RPS6KB1(2), SFN(1), SHC1(4), SLC2A4(2), SORBS1(3), SOS1(8), SOS2(7), YWHAB(1)	52288483	96	86	92	26	10	13	20	29	24	0	0.396	1.000	1.000
494	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	65	APAF1(3), BAD(1), BAK1(1), BCL2L11(1), BID(2), BIRC2(2), BIRC3(5), BIRC5(1), CASP1(3), CASP10(3), CASP2(1), CASP4(3), CASP7(1), CASP8(1), CASP9(2), CHUK(2), DFFA(1), DFFB(1), FAS(2), FASLG(2), HELLS(4), IKBKB(3), IRF2(2), IRF5(3), IRF6(6), IRF7(1), JUN(2), LTA(1), MAP3K1(7), MAPK10(2), MYC(1), NFKB1(2), NFKBIA(2), NFKBIB(2), PLEKHG5(1), PRF1(1), RELA(6), RIPK1(1), TNF(1), TNFRSF10B(1), TNFRSF1A(1), TNFRSF1B(1), TNFRSF21(4), TNFRSF25(1), TP73(4), TRADD(2), TRAF2(1), TRAF3(1)	55175807	102	85	95	29	8	18	16	29	30	1	0.544	1.000	1.000
495	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	ACHE(1), AGPAT1(1), CDS2(2), CHAT(5), CHKB(2), CHPT1(3), DGKA(4), DGKB(3), DGKD(3), DGKE(5), DGKG(5), DGKH(6), DGKI(1), DGKQ(3), DGKZ(5), ESCO1(2), ESCO2(1), ETNK1(3), ETNK2(1), GPAM(5), GPD1(1), GPD1L(3), GPD2(1), LCAT(5), LYPLA1(1), PCYT1A(1), PISD(1), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(4), PLD1(2), PLD2(5), PNPLA3(3), PPAP2B(1), PPAP2C(3), PTDSS1(2), SH3GLB1(3)	65536580	102	85	98	30	15	13	9	32	33	0	0.542	1.000	1.000
496	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	40	AGL(7), AMY2A(1), AMY2B(2), ENPP1(4), ENPP3(2), G6PC(3), GAA(3), GBE1(1), GCK(2), GUSB(5), GYS1(3), GYS2(3), HK1(6), MGAM(8), PGM1(1), PYGB(3), PYGL(2), PYGM(4), RNPC3(1), SI(9), UCHL1(1), UCHL3(1), UGDH(1), UGT1A1(5), UGT1A3(1), UGT1A4(2), UGT1A5(2), UGT1A6(3), UGT1A7(3), UGT1A9(5), UGT2B15(1), UGT2B4(4), UXS1(1)	56341088	100	85	99	31	11	10	16	36	27	0	0.692	1.000	1.000
497	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	40	ALAS1(5), ALAS2(5), BLVRA(1), COX10(5), COX15(3), CP(4), EPRS(4), FECH(2), FTMT(5), GUSB(5), HCCS(1), HMOX1(3), MMAB(1), PPOX(2), UGT1A1(5), UGT1A3(1), UGT1A4(2), UGT1A5(2), UGT1A6(3), UGT1A7(3), UGT1A9(5), UGT2A1(3), UGT2A3(3), UGT2B11(2), UGT2B15(1), UGT2B17(1), UGT2B28(5), UGT2B4(4), UGT2B7(6), UROD(2)	41298038	94	84	92	28	10	9	16	38	21	0	0.632	1.000	1.000
498	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	42	CHUK(2), DAXX(6), EGF(5), EGFR(9), ETS1(2), ETS2(1), FOS(1), HOXA7(1), HRAS(1), IKBKB(3), JUN(2), MAP2K3(3), MAP2K7(1), MAP3K1(7), MAP3K5(5), MAPK13(1), MAPK14(1), MAPK3(3), NFKB1(2), NFKBIA(2), PPP2CA(1), PRKCA(2), PRKCD(5), PRKCE(4), PRKCG(6), PRKCH(4), PRKCQ(5), RAF1(4), RELA(6), RIPK1(1), SP1(2), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TRAF2(1)	48453273	102	84	96	25	13	10	4	39	35	1	0.574	1.000	1.000
499	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	29	AKT1(2), AKT2(5), AKT3(3), BCR(1), CD19(1), DAPP1(2), FLOT2(1), GAB1(2), ITPR1(7), ITPR2(12), ITPR3(5), LYN(1), PDK1(1), PHF11(1), PITX2(2), PLCG2(4), PPP1R13B(4), PREX1(8), PTPRC(8), RPS6KA3(3), RPS6KB1(2), SAG(5), SYK(2), TEC(5), VAV1(4)	50477315	91	83	91	25	7	16	14	30	24	0	0.265	1.000	1.000
500	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(1), ACTN1(1), ACTN2(3), BCAR1(6), BCR(1), CAPN1(2), CRKL(1), CSK(4), FYN(2), GRB2(2), HRAS(1), ITGA1(8), ITGB1(7), JUN(2), MAP2K2(1), MAPK3(3), PPP1R12B(2), PTK2(3), PXN(3), RAF1(4), RAP1A(1), ROCK1(5), SHC1(4), SOS1(8), SRC(3), TLN1(13), VCL(2), ZYX(1)	46700891	94	82	93	26	6	13	8	41	25	1	0.600	1.000	1.000
501	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	52	ACAT1(1), ACMSD(2), ALDH1A1(1), ALDH1A2(1), ALDH1B1(4), ALDH2(4), ALDH3A2(2), AOC2(4), AOC3(2), AOX1(8), CAT(2), CYP19A1(2), CYP1A1(1), CYP1A2(4), CYP2A13(5), CYP2A6(4), CYP2A7(2), CYP2B6(1), CYP2C18(1), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP2D6(4), CYP2E1(1), CYP2F1(4), CYP2J2(3), CYP3A5(1), CYP3A7(2), CYP4B1(3), CYP51A1(2), DDC(3), ECHS1(3), EHHADH(6), HAAO(2), HADHA(4), KYNU(3), MAOA(2), MAOB(2), TPH1(2), WARS(1), WARS2(1)	52830338	103	82	102	27	16	14	15	40	18	0	0.198	1.000	1.000
502	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(3), COL4A2(2), COL4A3(7), COL4A4(4), COL4A5(8), COL4A6(7), F10(1), F11(2), F12(7), F2(3), F2R(2), F5(11), F8(8), F9(2), FGA(4), FGB(3), FGG(6), KLKB1(2), PROC(3), PROS1(5), SERPING1(2)	44687494	92	81	90	27	12	15	9	32	23	1	0.382	1.000	1.000
503	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	40	AKT1(2), ASAH1(2), ATF1(2), BRAF(4), CAMP(1), CREB5(3), CREBBP(9), CRKL(1), DAG1(3), EGR2(1), EGR3(2), EGR4(1), ELK1(1), FRS2(2), JUN(2), MAP1B(11), MAP2K7(1), MAPK10(2), MAPK3(3), MAPK8IP1(4), MAPK8IP2(1), MAPK8IP3(2), MAPK9(2), NTRK1(7), PIK3C2G(4), PIK3CD(2), PIK3R1(5), PTPN11(2), RPS6KA3(3), SHC1(4), SRC(3), TH(4)	47522751	96	81	94	29	12	20	10	32	21	1	0.417	1.000	1.000
504	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	35	AKT1(2), AKT2(5), AKT3(3), ARHGEF11(5), CDC42(1), DLG4(2), GNA13(4), LPA(9), MAP3K1(7), MAP3K5(5), NFKB1(2), NFKB2(3), NFKBIA(2), NFKBIB(2), NFKBIL1(2), PDK1(1), PHKA2(5), PI3(1), PIK3CB(5), PLD1(2), PLD2(5), PLD3(3), PTK2(3), RDX(2), ROCK1(5), ROCK2(3), TBXA2R(4)	48951973	93	81	89	29	12	11	11	36	23	0	0.660	1.000	1.000
505	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	44	ADH1A(2), ADH1B(2), ADH4(2), ADH6(2), ADHFE1(3), AGPAT1(1), AKR1A1(2), AKR1B1(3), ALDH1A1(1), ALDH1A2(1), ALDH1B1(4), ALDH2(4), ALDH3A2(2), CEL(3), DGAT1(2), DGKA(4), DGKB(3), DGKD(3), DGKE(5), DGKG(5), DGKH(6), DGKQ(3), DGKZ(5), GK(1), GLA(1), GLB1(5), LCT(7), LIPC(1), LIPF(1), LPL(3), PNLIP(4), PPAP2B(1), PPAP2C(3)	47288821	95	80	94	26	14	13	12	31	25	0	0.278	1.000	1.000
506	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(1), ARSD(2), ARSE(2), CYP11B1(4), CYP11B2(2), CYP19A1(2), HSD11B2(1), HSD17B1(1), HSD17B2(1), HSD17B7(1), HSD17B8(1), HSD3B1(1), LCMT1(1), LCMT2(4), METTL2B(1), PRMT2(2), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(2), PRMT8(3), SRD5A1(1), SULT1E1(2), SULT2A1(1), UGT1A1(5), UGT1A3(1), UGT1A4(2), UGT1A5(2), UGT1A6(3), UGT1A7(3), UGT1A9(5), UGT2A1(3), UGT2A3(3), UGT2B11(2), UGT2B15(1), UGT2B17(1), UGT2B28(5), UGT2B4(4), UGT2B7(6)	49477840	89	80	89	25	6	7	19	29	28	0	0.498	1.000	1.000
507	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	51	ADH1A(2), ADH1B(2), ADH4(2), ADH6(2), ADHFE1(3), AKR1A1(2), ALDH1A1(1), ALDH1A2(1), ALDH1B1(4), ALDH2(4), ALDH3A2(2), ALDH3B1(4), ALDH3B2(3), ALDOA(2), ALDOB(3), ALDOC(1), DLAT(2), DLD(4), ENO1(5), ENO2(1), ENO3(2), G6PC(3), GAPDH(4), GCK(2), HK1(6), LDHB(2), LDHC(3), PDHA1(1), PDHA2(3), PDHB(1), PFKM(3), PFKP(3), PGK1(3), PGM1(1), PKLR(1), TPI1(2)	46395404	90	78	86	27	10	5	15	29	30	1	0.657	1.000	1.000
508	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(1), AGPAT1(1), AGPS(5), CDS2(2), CHAT(5), CHKB(2), CLC(2), DGKA(4), DGKB(3), DGKD(3), DGKE(5), DGKG(5), DGKH(6), DGKQ(3), DGKZ(5), ETNK1(3), GPD1(1), GPD2(1), LCAT(5), LGALS13(1), LYPLA1(1), PAFAH1B1(1), PAFAH2(2), PCYT1A(1), PISD(1), PLA2G4A(2), PLA2G6(4), PLCB2(4), PLCG1(4), PLCG2(4), PPAP2B(1), PPAP2C(3)	49908150	91	78	88	26	15	14	8	27	27	0	0.368	1.000	1.000
509	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	AGXT(2), AGXT2(1), ALAS1(5), ALAS2(5), AOC2(4), AOC3(2), BHMT(7), CHDH(4), CHKB(2), CTH(2), DAO(1), DLD(4), DMGDH(4), GATM(1), GLDC(4), MAOA(2), MAOB(2), PISD(1), PLCB2(4), PLCG1(4), PLCG2(4), SARDH(4), SARS(2), SHMT1(2), SHMT2(5), TARS(5)	41967764	83	78	79	24	9	11	14	23	25	1	0.514	1.000	1.000
510	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	51	ADH1A(2), ADH1B(2), ADH4(2), ADH6(2), ADHFE1(3), AKR1A1(2), ALDH1A1(1), ALDH1A2(1), ALDH1B1(4), ALDH2(4), ALDH3A2(2), ALDH3B1(4), ALDH3B2(3), ALDOA(2), ALDOB(3), ALDOC(1), DLAT(2), DLD(4), ENO1(5), ENO2(1), ENO3(2), G6PC(3), GAPDH(4), GCK(2), HK1(6), LDHB(2), LDHC(3), PDHA1(1), PDHA2(3), PDHB(1), PFKM(3), PFKP(3), PGK1(3), PGM1(1), PKLR(1), TPI1(2)	46395404	90	78	86	27	10	5	15	29	30	1	0.657	1.000	1.000
511	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	42	ALDOA(2), ALDOB(3), ALDOC(1), DLAT(2), DLD(4), ENO1(5), ENO2(1), ENO3(2), G6PC(3), GAPDH(4), GAPDHS(5), GCK(2), GOT1(3), GOT2(2), HK1(6), LDHAL6B(1), LDHB(2), LDHC(3), MDH1(2), MDH2(1), PC(8), PCK1(5), PDHA1(1), PDHA2(3), PDHB(1), PDHX(2), PFKL(3), PFKM(3), PFKP(3), PGAM2(2), PGK1(3), PGK2(1), PKLR(1), TNFAIP1(1), TPI1(2)	40784007	93	78	90	27	6	8	14	23	41	1	0.654	1.000	1.000
512	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	B3GALNT1(1), B3GALT1(1), B3GALT2(2), B3GALT4(1), B3GALT5(3), B3GNT1(2), B3GNT2(3), B3GNT3(1), B3GNT5(1), B4GALNT1(2), B4GALT1(1), B4GALT3(2), B4GALT4(2), B4GALT6(1), FUT2(2), FUT3(2), FUT4(2), FUT6(4), FUT7(1), GBGT1(2), GCNT2(3), PIGB(2), PIGC(1), PIGG(1), PIGK(1), PIGL(2), PIGM(2), PIGN(3), PIGO(5), PIGP(1), PIGQ(4), PIGS(1), PIGT(6), PIGU(1), PIGV(1), PIGZ(3), ST3GAL1(2), ST3GAL3(3), ST3GAL4(2), ST3GAL5(1), ST6GALNAC3(3), ST6GALNAC5(4), ST6GALNAC6(1), ST8SIA1(2), ST8SIA5(1)	47664340	92	77	86	28	12	14	10	29	26	1	0.616	1.000	1.000
513	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	36	CALM2(1), ELK1(1), FCER1G(1), FOS(1), GRB2(2), HRAS(1), JUN(2), LYN(1), MAP2K7(1), MAP3K1(7), MAPK3(3), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), PAK2(4), PIK3R1(5), PLA2G4A(2), PLCG1(4), PPP3CA(3), PPP3CC(3), RAF1(4), SHC1(4), SOS1(8), SYK(2), SYT1(1), VAV1(4)	40063381	87	76	84	29	10	10	9	30	28	0	0.858	1.000	1.000
514	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(3), AARS2(3), CARS(6), CARS2(3), DARS(3), DARS2(1), EPRS(4), FARSA(2), HARS(1), HARS2(1), IARS(4), IARS2(3), LARS(7), LARS2(2), MARS(3), MARS2(4), MTFMT(1), NARS2(6), PARS2(3), QARS(1), RARS(3), RARS2(2), SARS(2), TARS(5), TARS2(7), VARS(4), VARS2(6), WARS(1), WARS2(1), YARS(1), YARS2(1)	53298830	94	76	90	25	3	15	10	40	26	0	0.519	1.000	1.000
515	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	49	ABL1(8), ACTG1(4), ARHGEF2(3), ARPC5L(1), CDC42(1), CDH1(2), CTNNB1(2), EZR(2), FYN(2), HCLS1(1), ITGB1(7), KRT18(1), LY96(1), NCK1(1), NCK2(2), NCL(5), OCLN(3), PRKCA(2), ROCK1(5), ROCK2(3), TLR4(3), TLR5(4), TUBA1A(2), TUBA3C(1), TUBA3D(2), TUBA4A(6), TUBAL3(3), TUBB(3), TUBB1(3), TUBB2B(2), TUBB8(4), WAS(1)	49217257	90	76	89	41	10	19	18	23	20	0	0.970	1.000	1.000
516	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	49	ABL1(8), ACTG1(4), ARHGEF2(3), ARPC5L(1), CDC42(1), CDH1(2), CTNNB1(2), EZR(2), FYN(2), HCLS1(1), ITGB1(7), KRT18(1), LY96(1), NCK1(1), NCK2(2), NCL(5), OCLN(3), PRKCA(2), ROCK1(5), ROCK2(3), TLR4(3), TLR5(4), TUBA1A(2), TUBA3C(1), TUBA3D(2), TUBA4A(6), TUBAL3(3), TUBB(3), TUBB1(3), TUBB2B(2), TUBB8(4), WAS(1)	49217257	90	76	89	41	10	19	18	23	20	0	0.970	1.000	1.000
517	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(1), F11(2), F12(7), F13B(4), F2(3), F5(11), F7(1), F8(8), F9(2), FGA(4), FGB(3), FGG(6), LPA(9), PLAT(4), PLG(8), SERPINB2(1), SERPINF2(2), VWF(15)	34880438	91	75	87	31	9	8	15	30	27	2	0.739	1.000	1.000
518	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	42	AGMAT(2), ALDH1A1(1), ALDH1A2(1), ALDH1B1(4), ALDH2(4), ALDH3A2(2), ALDH4A1(2), AMD1(2), AOC2(4), AOC3(2), ARG1(1), ARG2(1), ASL(4), CKB(1), CKMT1B(1), CPS1(5), DAO(1), GATM(1), GOT1(3), GOT2(2), MAOA(2), MAOB(2), NOS1(10), NOS3(3), OAT(2), ODC1(2), OTC(1), P4HA1(4), P4HA2(1), P4HA3(1), P4HB(3), PYCR1(1), RARS(3), SMS(2)	42884256	81	74	81	23	8	7	17	26	23	0	0.532	1.000	1.000
519	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	41	ACACA(9), ACACB(5), ACAT1(1), ACOT12(1), ACSS1(3), ACSS2(7), AKR1B1(3), ALDH1B1(4), ALDH2(4), ALDH3A2(2), ALDH7A1(1), DLAT(2), DLD(4), GLO1(1), GRHPR(2), HAGH(1), LDHAL6B(1), LDHB(2), LDHC(3), MDH1(2), MDH2(1), ME1(1), ME2(3), ME3(2), PC(8), PCK1(5), PCK2(2), PDHA1(1), PDHA2(3), PDHB(1), PKLR(1)	45475330	86	74	84	22	5	12	18	19	30	2	0.385	1.000	1.000
520	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CALM2(1), CAMK1(3), CAMK1G(3), ELK1(1), FPR1(2), GNA15(1), GNB1(3), HRAS(1), MAP2K2(1), MAP2K3(3), MAP3K1(7), MAPK14(1), MAPK3(3), NCF1(1), NCF2(1), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), NFKB1(2), NFKBIA(2), PAK1(3), PIK3C2G(4), PLCB1(3), PPP3CA(3), PPP3CC(3), RAF1(4), RELA(6), SYT1(1)	38247438	85	73	79	23	11	10	6	26	31	1	0.690	1.000	1.000
521	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR1(2), AGTR2(1), ATP8A1(2), AVPR1A(1), AVPR2(3), BDKRB1(1), BDKRB2(1), BRS3(2), C3AR1(3), CCKAR(4), CCKBR(3), CCR2(2), CCR3(2), CCR5(1), CCR6(1), CCR7(1), CX3CR1(1), CXCR4(1), CXCR6(1), EDNRB(3), FPR1(2), FSHR(2), GALR1(1), GALT(3), GRPR(2), MC1R(2), MC2R(2), MC3R(2), MC4R(1), MC5R(1), NPY1R(1), NPY2R(2), NTSR1(3), OPRD1(3), OPRK1(2), OPRL1(1), OPRM1(3), OXTR(1), SSTR1(3), SSTR2(2), SSTR3(2), SSTR4(3), TACR1(1), TACR2(1), TACR3(2), TRHR(2), TSHR(2)	50346108	88	73	88	29	16	11	13	35	13	0	0.437	1.000	1.000
522	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	AKT1(2), APC(9), ASAH1(2), CAMP(1), CAV3(1), DAG1(3), DLG4(2), EPHB2(2), GNAI1(2), ITPR1(7), ITPR2(12), ITPR3(5), KCNJ3(4), PITX2(2), RHO(1), RYR1(23)	45473864	78	73	78	20	14	11	13	25	15	0	0.189	1.000	1.000
523	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	39	ARNTL(3), BTG1(3), CBX3(1), CLOCK(4), CRY1(1), EIF4G2(4), ETV6(2), GSTP1(2), HERPUD1(3), HSPA8(8), IDI1(1), KLF9(2), MYF6(3), NCKAP1(2), NCOA4(7), NR1D2(2), PER1(5), PER2(6), PPP1R3C(1), PPP2CB(2), PSMA4(2), SF3A3(1), TOB1(5), UGP2(1), ZFR(6)	36283558	77	71	76	28	4	9	15	28	20	1	0.892	1.000	1.000
524	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	41	CDC6(2), CDC7(2), CDK2(2), CDT1(2), DIAPH2(2), MCM10(4), MCM2(10), MCM3(1), MCM4(1), MCM5(3), MCM6(5), MCM7(6), PCNA(3), POLD1(7), POLD3(1), POLE(5), POLE2(1), PRIM1(3), RFC1(5), RFC2(1), RFC4(2), RFC5(3), RPA1(2), RPA2(1), RPA3(1), RPA4(2), RPS27A(1), UBA52(1), UBB(1), UBC(4)	46885015	84	71	81	23	10	8	10	32	24	0	0.530	1.000	1.000
525	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	32	ACTA1(1), CRKL(1), DOCK1(3), ELK1(1), FOS(1), GAB1(2), GRB2(2), HGF(1), HRAS(1), ITGA1(8), ITGB1(7), JUN(2), MAP2K2(1), MAP4K1(4), MAPK3(3), PAK1(3), PIK3R1(5), PTK2(3), PTK2B(3), PTPN11(2), PXN(3), RAF1(4), RAP1A(1), RASA1(7), SOS1(8), SRC(3), STAT3(3)	39125202	83	71	82	23	4	17	8	29	25	0	0.645	1.000	1.000
526	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	20	ATM(19), ATR(12), BRCA1(7), BRCA2(12), CHEK1(1), CHEK2(2), FANCA(5), FANCD2(1), FANCE(2), FANCF(2), FANCG(4), HUS1(2), MRE11A(3), RAD17(2), RAD50(4), RAD51(2), TREX1(3)	43535384	83	70	82	20	6	14	11	34	18	0	0.350	1.000	1.000
527	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(1), CALM2(1), ELK1(1), FOS(1), GRB2(2), HRAS(1), JUN(2), LYN(1), MAP3K1(7), MAPK14(1), MAPK3(3), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), PLCG1(4), PPP3CA(3), PPP3CC(3), PRKCA(2), RAF1(4), SHC1(4), SOS1(8), SYK(2), SYT1(1), VAV1(4)	37521064	78	69	75	25	9	10	9	24	26	0	0.810	1.000	1.000
528	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(7), CREBBP(9), EP300(16), ERCC3(4), GRIP1(3), GTF2A1(2), GTF2E1(1), GTF2F1(1), HDAC1(2), HDAC4(1), HDAC5(3), HDAC6(3), NCOR2(6), NRIP1(5), PELP1(1), POLR2A(13), TBP(1)	46262931	78	69	74	45	6	9	12	26	25	0	1.000	1.000	1.000
529	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	33	ACTG1(4), ACTG2(1), ACTR2(2), AKT1(2), CDC42(1), CFL1(1), CFL2(1), FLNA(6), FLNC(10), FSCN1(4), FSCN2(1), FSCN3(2), GDI2(2), MYH2(9), MYLK(4), MYLK2(1), PAK1(3), PAK2(4), PAK3(1), PAK4(3), PAK6(5), PAK7(3), RHO(1), ROCK1(5), ROCK2(3), WASF1(1)	44641749	80	68	80	28	7	15	4	25	29	0	0.817	1.000	1.000
530	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	ARHGDIB(1), CASP10(3), CASP7(1), CASP8(1), CFLAR(1), DAXX(6), DFFA(1), DFFB(1), FAF1(1), JUN(2), LMNB1(3), LMNB2(1), MAP3K1(7), MAP3K7(3), PAK1(3), PAK2(4), PRKDC(12), PTPN13(8), RB1(4), RIPK2(4), SPTAN1(12)	42361490	79	67	79	24	6	7	11	25	27	3	0.724	1.000	1.000
531	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B3GNT6(4), B4GALT5(2), GALNT1(1), GALNT10(7), GALNT11(3), GALNT13(3), GALNT14(3), GALNT2(2), GALNT4(3), GALNT5(6), GALNT6(5), GALNT7(7), GALNT8(1), GALNT9(1), GALNTL5(3), GCNT1(2), GCNT3(2), GCNT4(3), OGT(5), ST3GAL1(2), ST6GALNAC1(2), WBSCR17(5)	32403597	72	67	68	27	5	7	15	25	20	0	0.900	1.000	1.000
532	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(2), ALOX12(3), ALOX12B(2), ALOX15B(3), ALOX5(4), CBR1(4), CYP2B6(1), CYP2C18(1), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP2E1(1), CYP2J2(3), CYP2U1(1), CYP4A11(5), CYP4A22(1), CYP4F2(4), CYP4F3(2), DHRS4(3), EPHX2(1), GGT1(4), GPX6(1), LTA4H(4), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(4), PTGDS(1), PTGS1(2), PTGS2(5), TBXAS1(4)	38801290	74	67	72	20	8	8	17	22	18	1	0.336	1.000	1.000
533	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(2), CALM2(1), ELK1(1), FOS(1), GNAI1(2), GNAS(6), GNB1(3), HRAS(1), JUN(2), MAPK3(3), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), PLCG1(4), PPP3CA(3), PPP3CC(3), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PRKCA(2), RAF1(4), RPS6KA3(3), SYT1(1)	33890354	74	66	71	22	11	8	6	26	23	0	0.709	1.000	1.000
534	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(2), ARG1(1), ARG2(1), ASL(4), ASS1(3), CKB(1), CKMT1B(1), CPS1(5), DAO(1), EPRS(4), GATM(1), GLUD2(7), GOT1(3), GOT2(2), LAP3(4), NOS1(10), NOS3(3), OAT(2), OTC(1), P4HA1(4), P4HA2(1), P4HA3(1), PARS2(3), PRODH(3), PYCR1(1), PYCR2(1), RARS(3), RARS2(2)	35757050	75	66	73	21	8	6	16	28	17	0	0.503	1.000	1.000
535	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	33	AKT1(2), BAD(1), CBL(3), CFLAR(1), CRKL(1), E2F1(1), FOS(1), GRB2(2), HRAS(1), IL2RA(2), IL2RB(2), IRS1(5), JAK1(6), JAK3(4), MAPK3(3), MYC(1), PIK3R1(5), PPIA(1), PTPN6(3), RAF1(4), RPS6KB1(2), SHC1(4), SOCS3(1), SOS1(8), STAT5A(3), STAT5B(3), SYK(2)	33198415	72	66	71	21	9	11	12	19	21	0	0.525	1.000	1.000
536	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(7), AR(5), ESR2(4), ESRRA(1), HNF4A(2), NR1D2(2), NR1H3(2), NR1I2(1), NR1I3(1), NR2C2(1), NR2E1(1), NR2F1(1), NR2F2(4), NR2F6(1), NR3C1(4), NR4A1(1), NR4A2(1), NR5A1(1), NR5A2(2), PGR(5), PPARD(1), PPARG(2), RARA(4), RARB(2), RARG(1), RORA(2), RORC(2), RXRB(4), RXRG(2), THRA(1), VDR(2)	40701245	70	66	69	25	10	10	13	25	12	0	0.720	1.000	1.000
537	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(3), BAD(1), BCL2A1(2), CASP1(3), CASP10(3), CASP2(1), CASP4(3), CASP7(1), CASP8(1), CASP9(2), CD40(1), DAXX(6), DFFA(1), DFFB(1), FAS(2), FASLG(2), IKBKE(3), LTA(1), NFKB1(2), NFKBIA(2), NGFR(1), NR3C1(4), NTRK1(7), PTPN13(8), RIPK1(1), TFG(2), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TRADD(2), TRAF2(1), TRAF3(1), TRAF6(2)	43389187	73	65	72	18	4	14	12	29	14	0	0.281	1.000	1.000
538	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	37	CCNH(1), ERCC3(4), GTF2B(2), GTF2E1(1), GTF2E2(3), GTF2F2(1), GTF2H1(2), GTF2H2(1), GTF2H4(1), ILK(4), MNAT1(1), POLR1A(6), POLR1B(4), POLR2A(13), POLR2B(7), POLR2F(4), POLR2I(1), POLR2J(1), POLR3B(5), POLR3H(1), POLR3K(1), TAF5(2), TAF6(2), TAF7(2), TBP(1)	35228221	71	65	66	21	5	7	8	24	27	0	0.702	1.000	1.000
539	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	23	ARNT(2), EIF1(2), EIF2B1(1), EIF2B2(1), EIF2B3(1), EIF2B4(1), EIF2B5(2), EIF2S2(2), EIF2S3(2), FLT1(8), FLT4(14), HIF1A(4), HRAS(1), KDR(6), NOS3(3), PIK3R1(5), PLCG1(4), PRKCA(2), PTK2(3), PXN(3), SHC1(4)	31583049	71	63	70	24	10	7	9	21	23	1	0.842	1.000	1.000
540	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	31	ACTR2(2), AKT1(2), DAG1(3), DGKA(4), GCA(3), ITGA9(3), ITPKA(1), ITPKB(3), ITPR1(7), ITPR2(12), ITPR3(5), MAPK3(3), NR1I3(1), PAK1(3), PDE3A(3), PDE3B(3), PI3(1), PIK3C2G(4), PIK3CD(2), PIK3R1(5)	46768437	70	62	70	22	8	12	8	26	16	0	0.594	1.000	1.000
541	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	ARHGDIB(1), BAG4(1), CASP2(1), CASP8(1), DFFA(1), DFFB(1), JUN(2), LMNB1(3), LMNB2(1), MADD(8), MAP3K1(7), MAP3K7(3), PAK1(3), PAK2(4), PRKDC(12), RB1(4), RIPK1(1), SPTAN1(12), TNF(1), TNFRSF1A(1), TRADD(2), TRAF2(1)	39344213	71	62	71	24	3	8	12	20	25	3	0.830	1.000	1.000
542	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	22	IMPA1(1), INPP4A(2), INPP4B(4), INPP5A(1), INPPL1(4), ITPKA(1), ITPKB(3), MIOX(2), OCRL(3), PIK3C2A(6), PIK3C2B(5), PIK3C2G(4), PIK3CB(5), PIK3CG(4), PLCB1(3), PLCB2(4), PLCB3(3), PLCB4(5), PLCD1(3), PLCG1(4), PLCG2(4)	42879605	71	61	70	23	5	7	5	30	24	0	0.902	1.000	1.000
543	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(3), AKR1B10(2), B4GALT1(1), G6PC(3), GAA(3), GALK1(1), GALK2(2), GALT(3), GANC(3), GCK(2), GLA(1), GLB1(5), HK1(6), LALBA(1), LCT(7), MGAM(8), PFKL(3), PFKM(3), PFKP(3), PGM1(1), RDH11(4), RDH13(1), UGP2(1)	38163708	67	60	66	25	9	8	8	22	20	0	0.889	1.000	1.000
544	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(4), ACTG2(1), ADCY3(6), ADCY9(7), ARF1(1), ARF3(3), ARF5(1), ARF6(1), ARL4D(1), ATP6V0A1(3), ATP6V0A2(2), ATP6V0A4(4), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(4), ATP6V1D(1), ATP6V1G1(1), GNAS(6), PDIA4(1), PLCG1(4), PLCG2(4), PRKCA(2), SEC61B(2), TRIM23(5)	36995340	67	60	65	23	5	6	9	29	18	0	0.878	1.000	1.000
545	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	18	ABL1(8), ATM(19), BRCA1(7), CDKN1A(3), CHEK1(1), CHEK2(2), JUN(2), MRE11A(3), NFKB1(2), NFKBIA(2), RAD50(4), RAD51(2), RBBP8(2), RELA(6), TP73(4)	28706811	67	59	63	20	7	9	6	25	18	2	0.753	1.000	1.000
546	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	39	AKR1B1(3), AKR1B10(2), ALDOA(2), ALDOB(3), ALDOC(1), FPGT(1), FUK(2), GMDS(2), GMPPA(2), GMPPB(2), HK1(6), KHK(6), MPI(1), MTMR1(2), MTMR2(3), MTMR6(1), PFKFB3(4), PFKFB4(1), PFKL(3), PFKM(3), PFKP(3), PGM2(2), PHPT1(1), PMM1(1), RDH11(4), RDH13(1), TPI1(2)	36558842	64	59	64	20	9	7	12	19	17	0	0.616	1.000	1.000
547	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	ATF2(2), CDC42(1), DAXX(6), ELK1(1), GRB2(2), HRAS(1), HSPB2(2), MAP3K1(7), MAP3K5(5), MAP3K7(3), MAP3K9(5), MAPK14(1), MAPKAPK2(1), MAX(5), MEF2A(2), MEF2D(1), MKNK1(2), MYC(1), PLA2G4A(2), RIPK1(1), RPS6KA5(2), SHC1(4), STAT1(5), TGFB2(2), TGFBR1(1), TRADD(2), TRAF2(1)	36779176	68	59	66	18	8	6	4	31	18	1	0.619	1.000	1.000
548	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSA(2), ARSD(2), ARSE(2), ASAH1(2), B4GALT6(1), CERK(6), DEGS1(2), DEGS2(1), ENPP7(2), GAL3ST1(4), GALC(3), GBA(3), GLA(1), GLB1(5), LCT(7), NEU1(1), PPAP2B(1), PPAP2C(3), SGMS1(1), SGPP1(2), SMPD1(4), SMPD2(3), SMPD4(2), SPHK1(1), SPHK2(1), SPTLC1(1), SPTLC2(2), UGT8(1)	34445146	66	56	62	24	11	12	6	21	16	0	0.752	1.000	1.000
549	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	MRPL13(1), MRPS7(1), RPL10A(2), RPL11(3), RPL13(1), RPL14(1), RPL18(3), RPL18A(2), RPL19(2), RPL21(1), RPL22L1(1), RPL24(1), RPL26(1), RPL27(1), RPL28(1), RPL3(3), RPL30(3), RPL31(1), RPL32(1), RPL34(1), RPL36AL(1), RPL38(1), RPL3L(3), RPL6(1), RPL7(1), RPL8(1), RPS11(1), RPS13(1), RPS2(2), RPS21(2), RPS24(2), RPS26(1), RPS27(1), RPS29(1), RPS3(2), RPS3A(1), RPS4Y1(1), RPS7(1), RPS8(1), RPS9(1), RPSA(1)	22043805	58	56	58	16	5	6	9	23	14	1	0.606	1.000	1.000
550	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(6), CALM2(1), CRKL(1), GRB2(2), HRAS(1), JUN(2), MAP2K2(1), MAP2K3(3), MAP3K1(7), MAPK14(1), MAPK3(3), PAK1(3), PLCG1(4), PRKCA(2), PTK2B(3), RAF1(4), SHC1(4), SOS1(8), SRC(3), SYT1(1)	28336172	60	55	59	20	4	11	4	24	16	1	0.882	1.000	1.000
551	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(1), ACTN1(1), ACTN2(3), CAPN1(2), ITGA1(8), ITGB1(7), ITGB3(3), PTK2(3), PXN(3), SPTAN1(12), SRC(3), TLN1(13)	28528464	59	55	58	20	3	8	5	23	20	0	0.857	1.000	1.000
552	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	28	AKT1(2), CABIN1(11), CALM2(1), CAMK1(3), CAMK1G(3), HDAC5(3), IGF1R(3), INS(1), MAPK14(1), MAPK7(4), MEF2A(2), MEF2D(1), NFATC1(4), NFATC2(8), PIK3R1(5), PPP3CA(3), PPP3CC(3), SYT1(1)	29222876	59	53	55	18	11	6	3	22	17	0	0.642	1.000	1.000
553	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	22	GHR(1), GRB2(2), HRAS(1), INS(1), IRS1(5), JAK2(7), MAPK3(3), PIK3R1(5), PLCG1(4), PRKCA(2), PTPN6(3), RAF1(4), SHC1(4), SLC2A4(2), SOS1(8), STAT5A(3), STAT5B(3)	26298599	58	52	56	19	6	7	9	21	15	0	0.798	1.000	1.000
554	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	25	AKT1(2), APC(9), AXIN1(4), CTNNB1(2), DVL1(1), FZD1(3), GNAI1(2), GSK3B(3), IRAK1(3), LBP(1), LEF1(3), LY96(1), NFKB1(2), PIK3R1(5), PPP2CA(1), RELA(6), TLR4(3), WNT1(2)	27878814	53	51	48	16	4	7	5	19	17	1	0.719	1.000	1.000
555	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(2), ATF1(2), CDC42(1), CREB5(3), DUSP10(1), EEF2K(4), EIF4E(2), ELK1(1), IL1R1(3), MAP2K3(3), MAP3K10(4), MAP3K4(7), MAP3K5(5), MAP3K7(3), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPKAPK2(1), MKNK1(2), MKNK2(1), MYEF2(1), NFKB1(2), NR2C2(1), TRAF6(2)	33387178	55	51	55	16	4	12	3	26	9	1	0.474	1.000	1.000
556	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	40	APAF1(3), BAK1(1), BID(2), BIRC2(2), BIRC3(5), CASP2(1), CASP7(1), CASP8(1), CASP9(2), FAS(2), FASLG(2), JUN(2), MAP3K1(7), MAPK10(2), MYC(1), NFKB1(2), NFKBIA(2), PARP1(5), PRF1(1), RELA(6), RIPK1(1), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TRADD(2), TRAF2(1)	35681958	57	50	54	21	2	13	9	15	17	1	0.864	1.000	1.000
557	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(3), F2R(2), F2RL3(1), GNAI1(2), GNB1(3), HRAS(1), ITGA1(8), ITGB1(7), MAPK3(3), PLA2G4A(2), PLCB1(3), PRKCA(2), PTGS1(2), PTK2(3), RAF1(4), SRC(3), SYK(2), TBXAS1(4)	24358796	55	50	54	19	5	7	8	16	18	1	0.823	1.000	1.000
558	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	32	CHUK(2), ELK1(1), FOS(1), IKBKB(3), IRAK1(3), JUN(2), LY96(1), MAP2K3(3), MAP3K1(7), MAP3K7(3), MAPK14(1), NFKB1(2), NFKBIA(2), RELA(6), TLR10(3), TLR2(2), TLR3(1), TLR4(3), TLR6(2), TLR7(5), TLR9(1), TRAF6(2)	36225584	56	50	52	15	5	9	3	21	16	2	0.545	1.000	1.000
559	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	19	AKT1(2), APAF1(3), ATM(19), BAD(1), BID(2), CASP7(1), CASP9(2), PRKCA(2), PTK2(3), PXN(3), STAT1(5), TLN1(13)	26635246	56	49	55	16	5	7	6	19	19	0	0.588	1.000	1.000
560	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(3), B4GALT1(1), G6PC(3), GAA(3), GALK1(1), GALK2(2), GALT(3), GCK(2), GLA(1), GLB1(5), HK1(6), LALBA(1), LCT(7), MGAM(8), PFKM(3), PFKP(3), PGM1(1)	32229810	53	49	52	22	7	6	5	16	19	0	0.963	1.000	1.000
561	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(11), CALM2(1), CAPN2(4), EP300(16), HDAC1(2), MEF2D(1), NFATC1(4), NFATC2(8), PPP3CA(3), PPP3CC(3), PRKCA(2), SYT1(1)	23801443	56	49	51	19	8	4	4	21	19	0	0.884	1.000	1.000
562	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	23	ATF2(2), BCR(1), BLNK(1), ELK1(1), FOS(1), GRB2(2), HRAS(1), JUN(2), LYN(1), MAP3K1(7), MAPK3(3), MAPK8IP3(2), PAPPA(4), RPS6KA3(3), SHC1(4), SOS1(8), SYK(2), VAV1(4), VAV2(4), VAV3(1)	30115663	54	49	54	16	5	11	7	19	12	0	0.474	1.000	1.000
563	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	31	APAF1(3), BID(2), BIRC2(2), BIRC3(5), CASP10(3), CASP7(1), CASP8(1), CASP9(2), CFLAR(1), CHUK(2), DFFA(1), DFFB(1), GAS2(3), NFKB1(2), NFKBIA(2), RELA(6), RIPK1(1), SPTAN1(12), TNFRSF10B(1), TNFRSF25(1), TRADD(2), TRAF2(1)	32754440	55	48	52	16	2	8	9	17	18	1	0.625	1.000	1.000
564	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	19	AKT1(2), EIF4A1(1), EIF4A2(4), EIF4E(2), EIF4EBP1(1), EIF4G1(7), EIF4G2(4), EIF4G3(7), GHR(1), IRS1(5), MAPK14(1), MAPK3(3), MKNK1(2), PDK2(3), PIK3R1(5), PRKCA(2), RPS6KB1(2)	23636160	52	48	52	16	6	9	6	20	11	0	0.618	1.000	1.000
565	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(4), GTF2A1(2), GTF2B(2), GTF2E1(1), GTF2F1(1), NCOA1(3), NCOA2(11), NCOA3(9), NCOR2(6), POLR2A(13), RARA(4), TBP(1)	24972585	57	48	50	28	5	6	7	15	24	0	0.983	1.000	1.000
566	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	24	ADCY1(2), AKT1(2), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), GNAS(6), GRB2(2), HRAS(1), MAPK14(1), MAPK3(3), PIK3R1(5), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PRKCA(2), RPS6KA5(2), SOS1(8)	25240236	49	47	49	15	6	8	3	22	10	0	0.654	1.000	1.000
567	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM2(1), DLG4(2), GRIN1(2), GRIN2A(8), GRIN2B(8), GRIN2D(2), NOS1(10), PPP3CA(3), PPP3CC(3), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PRKCA(2), SYT1(1)	25363665	52	47	51	19	10	8	4	21	9	0	0.707	1.000	1.000
568	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	25	BLVRA(1), CP(4), EPRS(4), FECH(2), GUSB(5), HCCS(1), HMOX1(3), PPOX(2), UGT1A1(5), UGT1A3(1), UGT1A4(2), UGT1A5(2), UGT1A6(3), UGT1A7(3), UGT1A9(5), UGT2B15(1), UGT2B4(4), UROD(2)	26672544	50	47	50	15	5	5	11	17	12	0	0.558	1.000	1.000
569	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	21	DLG4(2), EPHB2(2), F2(3), F2RL1(1), F2RL2(2), F2RL3(1), JUN(2), MAP2K5(3), MAPK7(4), MYEF2(1), PLD1(2), PLD2(5), PLD3(3), PTK2(3), RAF1(4), SRC(3), TEC(5), VAV1(4)	25929953	50	47	47	16	6	5	6	22	11	0	0.733	1.000	1.000
570	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CREBBP(9), EP300(16), NCOA3(9), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), RARA(4)	20453810	48	46	45	17	3	3	8	17	17	0	0.748	1.000	1.000
571	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	21	ADCY1(2), AKT1(2), ASAH1(2), GNAI1(2), GNB1(3), ITGAV(1), ITGB3(3), MAPK3(3), PDGFRA(6), PIK3R1(5), PLCB1(3), PRKCA(2), PTK2(3), SMPD1(4), SMPD2(3), SPHK1(1), SRC(3)	25133053	48	46	47	21	7	9	4	16	12	0	0.948	1.000	1.000
572	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	22	BCAR1(6), CXCR4(1), GNAI1(2), GNB1(3), HRAS(1), MAPK3(3), NFKB1(2), PIK3C2G(4), PIK3R1(5), PLCG1(4), PRKCA(2), PTK2(3), PTK2B(3), PXN(3), RAF1(4), RELA(6)	25800150	52	45	48	23	3	8	5	19	15	2	0.990	1.000	1.000
573	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	32	GORASP1(1), MAP2K7(1), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(3), MAPK8IP1(4), MAPK8IP2(1), MAPK8IP3(2), MAPK9(2), NFKB1(2), NFKB2(3), NFKBIA(2), NFKBIB(2), NFKBIL1(2), PIK3CD(2), PIK3R1(5), SYT1(1), TRAF2(1), TRAF3(1), TRAF5(5), TRAF6(2)	30930118	48	45	48	13	10	6	4	20	8	0	0.392	1.000	1.000
574	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	13	BAIAP2(2), CASP1(3), CASP7(1), CASP8(1), GAPDH(4), INS(1), ITCH(1), MAGI1(4), MAGI2(6), RERE(11), WWP1(8), WWP2(4)	18937442	46	44	43	17	9	2	5	19	11	0	0.933	1.000	1.000
575	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(3), CARS(6), DARS(3), EPRS(4), HARS(1), IARS(4), LARS(7), LARS2(2), MARS(3), MARS2(4), QARS(1), RARS(3), SARS(2), TARS(5), WARS(1), WARS2(1), YARS(1)	32235504	51	43	48	13	1	5	7	21	17	0	0.615	1.000	1.000
576	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	20	CCR3(2), CFL1(1), GNAS(6), GNB1(3), HRAS(1), MAPK3(3), MYL2(1), NOX1(7), PIK3C2G(4), PLCB1(3), PPP1R12B(2), PRKCA(2), PTK2(3), RAF1(4), ROCK2(3)	24333289	45	43	43	13	3	5	7	18	12	0	0.750	1.000	1.000
577	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	31	ADRA1A(4), ADRB2(2), CHRM1(2), CHRM2(6), CHRM3(3), CHRM5(2), DRD1(1), DRD2(1), DRD3(3), DRD5(4), HRH2(1), HTR1A(2), HTR1B(1), HTR1D(2), HTR1E(3), HTR1F(2), HTR2A(1), HTR2B(1), HTR2C(1), HTR4(2), HTR6(2), HTR7(2)	24622013	48	43	46	25	8	4	3	23	10	0	0.971	1.000	1.000
578	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSA(2), ARSB(1), ARSD(2), ARSE(2), ASAH1(2), GAL3ST1(4), GALC(3), GBA(3), GLA(1), GLB1(5), LCT(7), NEU1(1), PPAP2B(1), PPAP2C(3), SMPD1(4), SMPD2(3), SPTLC1(1), SPTLC2(2)	23445985	47	42	46	17	8	7	4	17	11	0	0.752	1.000	1.000
579	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(2), AP2A1(3), AP2M1(1), ARF1(1), BAD(1), EEA1(7), GSK3A(2), GSK3B(3), LYN(1), PFKL(3), PFKM(3), PFKP(3), PLCG1(4), PRKCE(4), PRKCZ(1), RAB5A(1), RPS6KB1(2), VAV2(4)	25044969	46	42	43	16	3	6	9	15	13	0	0.834	1.000	1.000
580	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	24	AKR1B1(3), ALDOA(2), ALDOB(3), ALDOC(1), FPGT(1), GCK(2), GMDS(2), GMPPA(2), GMPPB(2), HK1(6), KHK(6), MPI(1), PFKFB3(4), PFKFB4(1), PFKM(3), PFKP(3), PMM1(1), TPI1(2)	23303734	45	41	45	18	5	3	9	12	16	0	0.938	1.000	1.000
581	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	18	ADCY1(2), ARHGEF1(2), F2(3), F2R(2), F2RL3(1), GNA12(1), GNA13(4), GNAI1(2), GNB1(3), MAP3K7(3), PIK3R1(5), PLCB1(3), PPP1R12B(2), PRKCA(2), PTK2B(3), ROCK1(5)	23428080	43	40	43	13	8	5	3	16	10	1	0.600	1.000	1.000
582	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA1(1), ANXA3(3), ANXA4(4), ANXA6(3), CYP11A1(2), EDNRB(3), HPGD(1), HSD11B2(1), PLA2G4A(2), PTGDR(1), PTGDS(1), PTGER2(1), PTGER4(1), PTGFR(5), PTGIR(2), PTGS1(2), PTGS2(5), TBXAS1(4)	20337800	42	40	42	18	5	4	7	15	10	1	0.899	1.000	1.000
583	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(1), ACTN2(3), BCAR1(6), CSK(4), CTNNA1(7), CTNNA2(7), CTNNB1(2), PTK2(3), PXN(3), SRC(3), VCL(2)	19060330	41	39	41	17	5	5	6	16	8	1	0.900	1.000	1.000
584	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1R(6), DDX20(7), E2F1(1), ETS1(2), ETS2(1), FOS(1), HDAC5(3), HRAS(1), JUN(2), NCOR2(6), RBL2(5), SIN3A(4), SIN3B(3)	26135928	42	39	42	13	7	4	3	15	13	0	0.653	1.000	1.000
585	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	23	ASNS(2), CA1(1), CA13(2), CA14(3), CA5B(1), CA6(1), CA7(1), CA9(2), CPS1(5), CTH(2), GLS(6), GLS2(4), GLUD2(7), GLUL(2), HAL(1)	20492192	40	39	38	14	2	5	6	23	4	0	0.808	1.000	1.000
586	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(9), APOA1(1), CETP(1), DGAT1(2), LCAT(5), LDLR(3), LIPC(1), LPL(3), LRP1(12), SCARB1(2), SOAT1(4)	26955573	43	39	41	13	4	7	4	15	13	0	0.550	1.000	1.000
587	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(1), GALNT10(7), GALNT2(2), GALNT4(3), GALNT6(5), GALNT7(7), GALNT8(1), GALNT9(1), GCNT1(2), ST3GAL1(2), ST3GAL4(2), WBSCR17(5)	14590676	38	37	35	22	2	2	7	12	15	0	0.998	1.000	1.000
588	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	28	BAG4(1), BIRC2(2), BIRC3(5), CASP8(1), CFLAR(1), JUN(2), MAP3K3(2), MAP3K7(3), NFKB1(2), NFKB2(3), NFKBIA(2), NFKBIB(2), NFKBIL1(2), NR2C2(1), RALBP1(2), RIPK1(1), TNF(1), TNFAIP3(2), TNFRSF1A(1), TNFRSF1B(1), TRADD(2), TRAF2(1)	26674377	40	37	40	13	4	8	6	16	5	1	0.522	1.000	1.000
589	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	25	ATF1(2), CASP2(1), CHUK(2), IKBKB(3), JUN(2), LTA(1), MAP2K3(3), MAP3K1(7), MAPK14(1), NFKB1(2), NFKBIA(2), RELA(6), RIPK1(1), TANK(1), TNF(1), TNFRSF1A(1), TRADD(2), TRAF2(1)	24269862	39	36	36	12	3	5	2	15	13	1	0.865	1.000	1.000
590	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	11	ARF1(1), ARFGAP1(1), ARFGAP3(2), ARFGEF2(8), CLTA(1), CLTB(2), COPA(7), GBF1(12), GPLD1(2)	15853316	36	35	36	12	1	2	2	18	12	1	0.901	1.000	1.000
591	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(2), ALOX5(4), CYP1A2(4), CYP2C18(1), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP2E1(1), CYP2J2(3), CYP3A43(2), CYP3A5(1), CYP3A7(2), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(4), RDH11(4), RDH13(1)	23945609	37	35	37	16	5	3	4	16	9	0	0.863	1.000	1.000
592	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(1), AGPS(5), CHPT1(3), ENPP2(3), ENPP6(1), PAFAH1B1(1), PAFAH1B2(1), PAFAH2(2), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(4), PLD1(2), PLD2(5), PPAP2B(1), PPAP2C(3)	23345073	37	34	35	18	7	4	3	15	8	0	0.953	1.000	1.000
593	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	14	AKT1(2), BAD(1), GRB2(2), HRAS(1), IGF1R(3), IRS1(5), MAPK3(3), PIK3R1(5), RAF1(4), SHC1(4), SOS1(8)	16298899	38	34	38	12	7	6	4	14	7	0	0.557	1.000	1.000
594	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	11	AKT1(2), DPM2(1), GRB2(2), HRAS(1), NTRK1(7), PIK3R1(5), PLCG1(4), PRKCA(2), SHC1(4), SOS1(8)	13238470	36	34	34	13	2	7	2	15	10	0	0.857	1.000	1.000
595	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(1), COASY(2), DPYD(5), DPYS(4), ENPP1(4), ENPP3(2), ILVBL(3), PANK1(2), PANK2(5), PANK3(3), PANK4(1), PPCS(1), UPB1(1), VNN1(1)	17126387	35	33	35	12	3	3	4	14	11	0	0.804	1.000	1.000
596	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CCR5(1), CD3E(1), CD3G(2), ETV5(3), IL12RB1(4), IL12RB2(2), IL18R1(1), JAK2(7), JUN(2), MAPK14(1), STAT4(2), TYK2(7)	18708322	33	33	32	11	3	1	6	15	8	0	0.861	1.000	1.000
597	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	15	AKT1(2), GRB2(2), HRAS(1), MAPK3(3), MAPK7(4), MEF2A(2), MEF2D(1), NTRK1(7), PIK3R1(5), PLCG1(4), SHC1(4)	15350205	35	32	32	12	4	4	3	17	7	0	0.802	1.000	1.000
598	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	21	ADCY1(2), AKT1(2), BAD(1), CSF2RB(5), IGF1R(3), IL3(1), KITLG(2), PIK3R1(5), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3)	19485402	31	30	31	15	8	2	1	13	7	0	0.903	1.000	1.000
599	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	ASNS(2), CA1(1), CA14(3), CA5B(1), CA6(1), CA7(1), CA9(2), CPS1(5), CTH(2), GLS(6), GLS2(4), GLUL(2), HAL(1)	18914320	31	30	31	10	1	4	4	18	4	0	0.759	1.000	1.000
600	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(6), JAK2(7), JAK3(4), MAPK3(3), STAT3(3), TYK2(7)	11689003	30	30	29	10	2	0	8	11	9	0	0.864	1.000	1.000
601	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(3), ARHGDIB(1), BIRC2(2), BIRC3(5), CASP1(3), CASP10(3), CASP2(1), CASP4(3), CASP7(1), CASP8(1), CASP9(2), DFFA(1), DFFB(1), LMNB1(3), LMNB2(1), PRF1(1)	19078382	32	29	32	12	0	8	6	10	8	0	0.801	1.000	1.000
602	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(5), EGFR(9), MAP3K1(7), MAPK14(1), NCOR2(6), RARA(4), THRA(1)	17113989	33	29	31	11	2	5	5	9	12	0	0.838	1.000	1.000
603	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(1), PSMA3(2), PSMA4(2), PSMA6(3), PSMA7(1), PSMB1(2), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(1), PSMC2(1), PSMD1(2), PSMD11(4), PSMD12(1), PSMD13(2), PSMD2(5), PSMD6(2)	16157887	32	29	31	11	3	3	4	8	14	0	0.850	1.000	1.000
604	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(3), CLOCK(4), CRY1(1), CSNK1E(3), NPAS2(1), PER1(5), PER2(6), PER3(6)	16900305	29	29	27	13	4	2	7	9	7	0	0.916	1.000	1.000
605	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(9), EP300(16), MAPK3(3), PELP1(1), SRC(3)	14702121	32	29	29	15	2	4	6	9	11	0	0.936	1.000	1.000
606	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	12	ARNT(2), COPS5(1), EP300(16), HIF1A(4), JUN(2), NOS3(3), P4HB(3)	16599924	31	28	28	11	1	0	3	11	15	1	0.924	1.000	1.000
607	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	DRD1(1), DRD2(1), GRM1(4), PLCB1(3), PPP1CA(1), PPP1R1B(1), PPP2CA(1), PPP3CA(3), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3)	15890797	25	25	25	13	4	0	0	10	11	0	0.959	1.000	1.000
608	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	GOSR1(1), SNAP23(1), SNAP29(1), STX10(1), STX11(2), STX16(1), STX17(1), STX18(1), STX19(1), STX2(2), STX4(2), STX5(1), STX7(1), STX8(1), TSNARE1(3), USE1(1), VAMP1(1), VAMP2(1), VTI1A(1)	16806685	24	24	24	11	4	4	3	9	4	0	0.801	1.000	1.000
609	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAS1(5), ALAS2(5), CPO(1), FECH(2), GATA1(4), HBB(3), UROD(2)	8054820	22	22	20	10	2	2	3	10	5	0	0.912	1.000	1.000
610	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(4), GABRA1(3), GABRA2(1), GABRA3(1), GABRA4(1), GABRA5(1), GABRA6(1), GPHN(4), SRC(3), UBQLN1(3)	12058520	22	21	22	11	2	4	5	8	2	1	0.904	1.000	1.000
611	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	6	AKT1(2), PIK3R1(5), PLCB1(3), PLCG1(4), PRKCA(2), VAV1(4)	10730507	20	19	19	11	3	3	2	5	7	0	0.978	1.000	1.000
612	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	9	ESR2(4), ITPKA(1), PDE1A(1), PDE1B(5), PLCB1(3), PLCB2(4)	10564147	18	18	18	11	6	2	0	4	6	0	0.974	1.000	1.000
613	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM2(1), CCL2(1), CCR5(1), CXCR4(1), FOS(1), JUN(2), MAPK14(1), PLCG1(4), PRKCA(2), PTK2B(3), SYT1(1)	13655108	18	16	17	10	2	4	2	6	4	0	0.965	1.000	1.000
614	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	10	ACTA1(1), ACTR2(2), ARPC1B(1), CDC42(1), WASF1(1)	6507194	6	6	6	5	0	3	0	3	0	0	0.974	1.000	1.000
615	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(3), SUCLA2(2)	2083524	5	5	5	3	0	2	1	2	0	0	0.875	1.000	1.000
616	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	TPI1(2)	1622802	2	2	2	2	0	0	2	0	0	0	0.932	1.000	1.000
