		Clinical Features	MRNA_CNMF		MRNA_CHIERARCHICAL		CN_CNMF		METHLYATION_CNMF		RPPA_CNMF		RPPA_CHIERARCHICAL		MRNASEQ_CNMF		MRNASEQ_CHIERARCHICAL		MIRSEQ_CNMF		MIRSEQ_CHIERARCHICAL		MIRSEQ_MATURE_CNMF		MIRSEQ_MATURE_CHIERARCHICAL	
	nMutated (%)	nWild-Type	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q
IDH1	398 (78%)	115	0.22425	0.732	0.88277	1	9.9999e-06	0.00019	9.9999e-06	0.00019	0.00178	0.0211	0.00060999	0.00842	9.9999e-06	0.00019	9.9999e-06	0.00019	2e-05	0.000354	9.9999e-06	0.00019	9.9999e-06	0.00019	9.9999e-06	0.00019
TP53	248 (48%)	265	0.096009	0.461	0.0062799	0.0615	9.9999e-06	0.00019	9.9999e-06	0.00019	0.00359	0.0382	0.00338	0.037	9.9999e-06	0.00019	9.9999e-06	0.00019	9.9999e-06	0.00019	2e-05	0.000354	0.053149	0.307	9.9999e-06	0.00019
ATRX	195 (38%)	318	0.0264	0.193	0.11782	0.516	9.9999e-06	0.00019	9.9999e-06	0.00019	0.090349	0.444	0.03857	0.248	9.9999e-06	0.00019	9.9999e-06	0.00019	9.9999e-06	0.00019	3e-05	0.000513	0.26216	0.791	9.9999e-06	0.00019
CIC	108 (21%)	405	0.050259	0.301	0.00313	0.0351	9.9999e-06	0.00019	9.9999e-06	0.00019	0.04859	0.293	0.3753	0.905	9.9999e-06	0.00019	9.9999e-06	0.00019	9.9999e-06	0.00019	9.9999e-06	0.00019	9.9999e-06	0.00019	9.9999e-06	0.00019
NOTCH1	42 (8%)	471	0.61515	1	0.27951	0.806	2e-04	0.00305	9.9999e-06	0.00019	0.60824	1	0.62111	1	9.9999e-06	0.00019	9.9999e-06	0.00019	2e-04	0.00305	0.00479	0.0491	0.00157	0.0188	0.00013	0.00208
IDH2	20 (4%)	493	NA	NA	NA	NA	0.00132	0.0162	0.00036	0.00526	0.24649	0.764	0.089069	0.44	0.0078399	0.0718	0.00023	0.00341	0.0096499	0.0859	0.00058999	0.00826	0.00297	0.0336	0.04646	0.284
PIK3R1	22 (4%)	491	0.61416	1	0.58007	1	0.0195	0.149	0.00193	0.0226	0.94742	1	0.83095	1	0.1269	0.54	0.03679	0.241	0.086239	0.428	0.58702	1	0.96112	1	0.62851	1
FUBP1	47 (9%)	466	0.02358	0.177	0.0069899	0.0658	9.9999e-06	0.00019	9.9999e-06	0.00019	0.62398	1	0.68248	1	9.9999e-06	0.00019	9.9999e-06	0.00019	9.9999e-06	0.00019	0.00112	0.0141	0.0082899	0.0753	9.9999e-06	0.00019
NF1	33 (6%)	480	NA	NA	NA	NA	0.00115	0.0143	9.9999e-06	0.00019	0.03649	0.24	0.18452	0.671	9.9999e-06	0.00019	9.9999e-06	0.00019	0.33788	0.843	0.00018	0.00283	0.0052999	0.0529	9.9999e-06	0.00019
ARID1A	20 (4%)	493	NA	NA	NA	NA	0.69348	1	0.080009	0.407	0.25495	0.772	0.6353	1	0.03236	0.22	0.14011	0.584	0.31534	0.832	0.60764	1	0.084369	0.423	0.0288	0.203
PTEN	24 (5%)	489	NA	NA	NA	NA	9.9999e-06	0.00019	9.9999e-06	0.00019	0.01286	0.107	0.00211	0.0244	9.9999e-06	0.00019	9.9999e-06	0.00019	0.00354	0.0382	9.9999e-06	0.00019	2e-05	0.000354	9.9999e-06	0.00019
EGFR	35 (7%)	478	NA	NA	NA	NA	9.9999e-06	0.00019	9.9999e-06	0.00019	0.30375	0.83	0.055739	0.316	9.9999e-06	0.00019	9.9999e-06	0.00019	0.01055	0.0917	9.9999e-06	0.00019	9.9999e-06	0.00019	9.9999e-06	0.00019
GAGE2A	8 (2%)	505	NA	NA	NA	NA	0.81479	1	1	1	0.96222	1	1	1	0.72402	1	0.62077	1	0.65478	1	0.90096	1	0.82083	1	0.92349	1
NUDT11	11 (2%)	502	NA	NA	NA	NA	1	1	0.84782	1	0.45551	0.964	0.85415	1	0.20348	0.714	0.15635	0.628	0.02547	0.189	0.91908	1	0.16964	0.65	0.29578	0.83
PIK3CA	44 (9%)	469	NA	NA	NA	NA	6.9999e-05	0.00116	2e-05	0.000354	0.32912	0.832	0.56584	1	0.00111	0.0141	3e-05	0.000513	0.0103	0.0903	0.03856	0.248	0.32903	0.832	0.00090999	0.0119
STK19	10 (2%)	503	NA	NA	NA	NA	0.42176	0.947	0.11128	0.505	0.39551	0.914	0.69047	1	0.29944	0.83	0.71899	1	0.16935	0.65	0.54469	1	0.92231	1	0.84331	1
EMG1	6 (1%)	507	NA	NA	NA	NA	1	1	0.8562	1	0.64081	1	0.42431	0.948	0.40764	0.934	0.28467	0.811	0.40916	0.935	0.43084	0.954	0.52989	1	0.72347	1
SMARCA4	26 (5%)	487	NA	NA	NA	NA	0.0114	0.0974	0.10334	0.484	0.18658	0.674	0.9559	1	0.32689	0.832	0.45181	0.964	0.30529	0.83	0.2452	0.764	0.8726	1	0.16422	0.644
NIPBL	18 (4%)	495	NA	NA	NA	NA	0.03738	0.243	0.00076999	0.0102	0.38761	0.914	0.22948	0.737	0.00373	0.0392	0.00482	0.0491	0.4502	0.964	0.17196	0.651	0.01076	0.0927	0.059059	0.331
TCF12	15 (3%)	498	NA	NA	NA	NA	0.67096	1	0.57854	1	0.76103	1	0.50807	1	0.8167	1	0.47677	0.973	0.69848	1	0.517	1	1	1	0.51585	1
DNMT3A	10 (2%)	503	NA	NA	NA	NA	0.66233	1	0.64647	1	0.52431	1	0.47566	0.973	0.63091	1	0.94159	1	0.48041	0.976	0.04418	0.273	0.92223	1	0.97186	1
TRERF1	6 (1%)	507	NA	NA	NA	NA	0.2435	0.764	0.12314	0.531	0.56045	1	0.35132	0.866	0.39193	0.914	0.57493	1	0.39014	0.914	0.75685	1	0.101	0.476	0.35358	0.867
CREBZF	7 (1%)	506	NA	NA	NA	NA	0.052509	0.307	0.0075799	0.0701	0.22464	0.732	0.03526	0.234	0.28117	0.806	0.0226	0.171	0.20238	0.713	0.01367	0.112	0.11568	0.514	0.053549	0.307
FAM47C	18 (4%)	495	NA	NA	NA	NA	0.30717	0.83	0.81827	1	0.46339	0.965	0.25206	0.768	0.27771	0.804	0.01188	0.101	0.61752	1	0.092629	0.449	0.0085099	0.0766	0.00332	0.0368
MYST4	11 (2%)	502	NA	NA	NA	NA	0.02443	0.182	0.12535	0.538	0.12755	0.54	0.70297	1	0.26809	0.796	0.34292	0.853	0.20084	0.71	1	1	0.062449	0.344	0.61091	1
MED9	3 (1%)	510	NA	NA	NA	NA	0.1748	0.653	0.36751	0.894	0.33581	0.84	0.22876	0.737	0.21818	0.728	0.84988	1	0.87716	1	0.79406	1	0.64971	1	0.51129	1
IRS4	7 (1%)	506	NA	NA	NA	NA	0.082379	0.417	0.37705	0.905	0.67195	1	0.57911	1	0.60264	1	0.13691	0.575	0.41465	0.941	0.69196	1	0.26921	0.796	1	1
HTRA2	5 (1%)	508	NA	NA	NA	NA	0.02978	0.207	0.42007	0.946	1	1	1	1	0.95338	1	0.63858	1	0.34835	0.861	0.72437	1	0.55927	1	0.47252	0.973
NRAS	4 (1%)	509	NA	NA	NA	NA	0.56484	1	0.50815	1	1	1	0.32468	0.832	0.418	0.945	0.1072	0.496	0.30455	0.83	0.68335	1	0.33443	0.839	0.75893	1
TNRC18	9 (2%)	504	NA	NA	NA	NA	0.9076	1	0.23237	0.741	0.44443	0.964	0.54218	1	0.19077	0.684	0.57719	1	0.6803	1	0.37342	0.903	0.82234	1	0.57819	1
ZNF709	4 (1%)	509	NA	NA	NA	NA	0.6901	1	1	1	1	1	0.67752	1	0.21891	0.728	0.23047	0.737	1	1	0.68225	1	0.27163	0.796	1	1
PLXNA3	9 (2%)	504	NA	NA	NA	NA	0.21111	0.716	0.27158	0.796	0.158	0.629	0.21674	0.728	0.19862	0.705	0.31042	0.832	0.35311	0.867	0.22667	0.732	0.482	0.977	0.87654	1
ROBO3	5 (1%)	508	NA	NA	NA	NA	0.62155	1	0.90417	1	0.84664	1	0.53824	1	0.82785	1	0.70624	1	0.4035	0.929	0.28707	0.815	1	1	0.92577	1
RB1	6 (1%)	507	NA	NA	NA	NA	0.00022	0.00331	0.00076999	0.0102	0.87182	1	0.84611	1	0.01662	0.132	0.096839	0.463	0.60098	1	0.03271	0.22	0.78113	1	0.24635	0.764
SRPX	4 (1%)	509	NA	NA	NA	NA	0.22436	0.732	0.10544	0.49	0.67485	1	0.2515	0.768	0.20591	0.714	0.14369	0.596	0.2757	0.803	0.19787	0.705	0.39502	0.914	0.062489	0.344
PDGFRA	10 (2%)	503	NA	NA	NA	NA	0.32033	0.832	0.062979	0.345	0.12668	0.54	0.22672	0.732	0.0065399	0.0622	0.00011	0.00179	0.00055999	0.00795	0.00155	0.0188	0.85368	1	0.18442	0.671
ZNF512B	5 (1%)	508	NA	NA	NA	NA	0.45255	0.964	0.81677	1	0.93194	1	0.42894	0.954	1	1	0.85098	1	1	1	1	1	0.45647	0.964	0.24764	0.766
ZMIZ1	9 (2%)	504	NA	NA	NA	NA	0.051259	0.303	0.32902	0.832	0.18055	0.667	0.24219	0.763	0.53033	1	0.29817	0.83	0.4777	0.973	0.67804	1	0.01881	0.147	0.42056	0.946
TMEM216	3 (1%)	510	NA	NA	NA	NA	0.25086	0.768	1	1	0.70785	1	0.59706	1	1	1	0.44305	0.964	0.51959	1	0.60438	1	0.30034	0.83	0.66736	1
ARID2	11 (2%)	502	NA	NA	NA	NA	0.85894	1	0.2641	0.791	0.78348	1	0.64446	1	0.4633	0.965	0.65072	1	0.60319	1	0.34761	0.861	0.48364	0.977	0.45786	0.964
RBPJ	7 (1%)	506	NA	NA	NA	NA	1	1	0.18069	0.667	0.1082	0.498	0.051379	0.303	0.43511	0.96	6.9999e-05	0.00116	0.33016	0.832	0.0282	0.201	0.11385	0.51	0.44609	0.964
CUL4B	10 (2%)	503	NA	NA	NA	NA	0.29578	0.83	0.04637	0.284	0.27696	0.804	0.3682	0.894	0.091499	0.446	0.070769	0.375	0.19	0.684	0.0071499	0.0667	1	1	0.3786	0.906
SLC6A3	9 (2%)	504	NA	NA	NA	NA	0.69974	1	0.87701	1	0.32336	0.832	0.0097199	0.0859	0.74015	1	0.48709	0.977	0.17341	0.651	0.50564	1	0.70569	1	0.53694	1
SETD2	10 (2%)	503	NA	NA	NA	NA	0.03944	0.252	0.064049	0.349	1	1	0.89779	1	0.00050999	0.00734	0.053109	0.307	0.60529	1	0.094779	0.457	0.8532	1	0.3769	0.905
KRT3	4 (1%)	509	NA	NA	NA	NA	0.82048	1	0.8804	1	0.79166	1	0.30726	0.83	0.64237	1	0.73812	1	0.2737	0.8	0.1963	0.702	0.39515	0.914	0.21076	0.716
MYT1	6 (1%)	507	NA	NA	NA	NA	0.01517	0.123	0.20765	0.714	NA	NA	NA	NA	0.44812	0.964	0.03242	0.22	0.43042	0.954	0.75678	1	0.45397	0.964	0.94108	1
SMOC1	3 (1%)	510	NA	NA	NA	NA	1	1	1	1	NA	NA	NA	NA	1	1	0.81785	1	0.59781	1	1	1	0.65224	1	0.18275	0.671
ZBTB20	21 (4%)	492	NA	NA	NA	NA	0.01265	0.106	0.00061999	0.00845	0.83703	1	0.29514	0.83	0.01325	0.109	0.0038	0.0395	0.159	0.631	0.01945	0.149	0.04061	0.257	0.03289	0.22
PPL	6 (1%)	507	NA	NA	NA	NA	0.76965	1	1	1	0.21076	0.716	0.57602	1	0.84274	1	0.24893	0.767	0.14604	0.602	0.75801	1	0.32871	0.832	0.72588	1
PTPN11	7 (1%)	506	NA	NA	NA	NA	0.54894	1	0.01875	0.147	0.50049	0.997	0.84653	1	0.053399	0.307	0.22635	0.732	0.22006	0.73	0.0051599	0.052	0.01659	0.132	0.00244	0.0279
RET	7 (1%)	506	NA	NA	NA	NA	0.55135	1	0.31946	0.832	0.62347	1	0.8361	1	0.37293	0.903	0.44565	0.964	0.70663	1	0.15248	0.615	0.15016	0.612	0.25379	0.771
ANKRD36	7 (1%)	506	NA	NA	NA	NA	0.02612	0.192	0.11223	0.507	0.44083	0.964	0.17062	0.651	0.60119	1	0.44873	0.964	0.73852	1	1	1	0.89543	1	0.94797	1
NEU2	5 (1%)	508	NA	NA	NA	NA	0.52933	1	0.81622	1	0.87017	1	1	1	0.078129	0.4	0.86873	1	0.30315	0.83	1	1	0.4587	0.964	0.71283	1
PRX	10 (2%)	503	NA	NA	NA	NA	0.11432	0.51	0.03296	0.22	0.83647	1	0.83737	1	0.38889	0.914	0.059969	0.334	0.5355	1	0.00104	0.0134	0.18543	0.672	0.074219	0.387
RBBP6	6 (1%)	507	NA	NA	NA	NA	0.58306	1	0.32117	0.832	1	1	0.097359	0.463	0.02753	0.198	0.0061399	0.0607	0.28063	0.806	0.065619	0.354	0.085249	0.425	0.17854	0.664
CIB1	4 (1%)	509	NA	NA	NA	NA	0.82235	1	1	1	0.62264	1	0.53916	1	0.60765	1	0.17342	0.651	0.2188	0.728	0.04391	0.273	0.12024	0.525	0.31995	0.832
DDX5	5 (1%)	508	NA	NA	NA	NA	1	1	1	1	1	1	0.61296	1	0.61464	1	0.48535	0.977	0.26391	0.791	0.439	0.963	0.02826	0.201	0.31685	0.832
NAP1L2	4 (1%)	509	NA	NA	NA	NA	0.68906	1	1	1	0.89367	1	0.04797	0.291	0.38113	0.908	0.068359	0.365	1	1	0.83037	1	1	1	1	1
SCN4A	6 (1%)	507	NA	NA	NA	NA	0.11283	0.508	0.34661	0.861	0.56665	1	0.8673	1	0.48736	0.977	0.11053	0.504	0.57123	1	0.86602	1	0.067999	0.365	0.41542	0.941
AGBL1	5 (1%)	508	NA	NA	NA	NA	0.16292	0.641	0.11684	0.514	0.1623	0.641	0.050539	0.301	0.03119	0.215	0.0436	0.273	0.20797	0.714	0.0064599	0.062	0.13616	0.574	0.0036	0.0382
TPX2	5 (1%)	508	NA	NA	NA	NA	1	1	0.81946	1	1	1	1	1	0.82888	1	0.38796	0.914	0.48778	0.977	0.074409	0.387	0.16591	0.648	0.31997	0.832
KRT15	6 (1%)	507	NA	NA	NA	NA	0.32977	0.832	1	1	1	1	0.78715	1	0.48885	0.978	0.46571	0.966	0.51776	1	0.86807	1	1	1	1	1
HTR3A	7 (1%)	506	NA	NA	NA	NA	0.62028	1	0.15187	0.615	0.84599	1	1	1	0.66123	1	0.38297	0.908	0.16882	0.65	0.24504	0.764	0.57187	1	0.87166	1
C14ORF4	3 (1%)	510	NA	NA	NA	NA	0.46743	0.966	0.67699	1	NA	NA	NA	NA	1	1	0.84978	1	1	1	0.79299	1	0.64937	1	0.43967	0.963
R3HDM1	7 (1%)	506	NA	NA	NA	NA	1	1	0.82593	1	0.26967	0.796	0.72986	1	0.85564	1	0.62487	1	0.73835	1	0.78384	1	0.074549	0.387	0.94817	1
G6PC	6 (1%)	507	NA	NA	NA	NA	0.3291	0.832	0.14626	0.602	0.9003	1	1	1	0.60773	1	0.083189	0.419	0.43248	0.956	0.14853	0.609	0.29659	0.83	0.76484	1
DLC1	6 (1%)	507	NA	NA	NA	NA	0.072269	0.381	0.23587	0.745	0.6712	1	0.83698	1	0.44843	0.964	0.52669	1	0.88896	1	0.15045	0.612	0.78268	1	0.13929	0.583
SLC12A7	7 (1%)	506	NA	NA	NA	NA	0.16726	0.65	0.40501	0.93	0.38269	0.908	0.32101	0.832	0.92212	1	0.86337	1	0.87123	1	0.78614	1	0.89579	1	1	1
SMARCB1	4 (1%)	509	NA	NA	NA	NA	0.82168	1	0.88001	1	0.064479	0.349	0.31015	0.832	0.92515	1	0.59231	1	0.43853	0.963	0.68098	1	0.076029	0.393	0.39485	0.914
WRN	5 (1%)	508	NA	NA	NA	NA	0.20804	0.714	0.076339	0.393	0.9071	1	0.53694	1	0.0296	0.207	0.01602	0.129	0.057039	0.321	1	1	0.04343	0.273	0.45175	0.964
LAMA4	4 (1%)	509	NA	NA	NA	NA	0.4523	0.964	0.30441	0.83	1	1	0.32441	0.832	0.10448	0.488	0.51867	1	0.69963	1	1	1	0.47559	0.973	0.83939	1
MAST2	5 (1%)	508	NA	NA	NA	NA	0.72758	1	0.46307	0.965	0.68637	1	0.2825	0.807	0.72286	1	0.215	0.725	0.01915	0.148	0.52936	1	0.86965	1	0.71679	1
ZMYM2	7 (1%)	506	NA	NA	NA	NA	0.62057	1	0.66533	1	0.58727	1	0.2816	0.806	0.62599	1	0.32076	0.832	0.12308	0.531	0.20839	0.714	0.27064	0.796	0.36462	0.892
SLFN11	4 (1%)	509	NA	NA	NA	NA	0.8237	1	0.88012	1	1	1	0.41505	0.941	0.31076	0.832	0.71288	1	0.59052	1	0.26488	0.791	0.47457	0.973	0.75915	1
C4BPA	6 (1%)	507	NA	NA	NA	NA	0.32877	0.832	0.29695	0.83	0.31348	0.832	0.53623	1	0.90058	1	0.38222	0.908	0.72979	1	0.50517	1	1	1	1	1
TMEM184A	3 (1%)	510	NA	NA	NA	NA	0.46765	0.966	0.29957	0.83	0.89315	1	1	1	0.58431	1	0.17373	0.651	0.87798	1	0.23414	0.742	0.4137	0.941	0.50987	1
KTELC1	5 (1%)	508	NA	NA	NA	NA	1	1	0.66786	1	0.31153	0.832	0.53682	1	0.9527	1	0.78786	1	0.11618	0.514	0.0063699	0.0617	1	1	0.10867	0.498
ASXL2	3 (1%)	510	NA	NA	NA	NA	0.46499	0.966	0.30141	0.83	0.62851	1	0.59728	1	0.82927	1	0.3175	0.832	0.52367	1	0.79498	1	0.20621	0.714	1	1
CCDC135	7 (1%)	506	NA	NA	NA	NA	0.70088	1	1	1	0.39692	0.916	0.42616	0.95	0.48734	0.977	0.02723	0.197	0.65834	1	1	1	0.80179	1	0.73297	1
SLC25A5	4 (1%)	509	NA	NA	NA	NA	0.45608	0.964	0.22614	0.732	NA	NA	NA	NA	0.92647	1	0.42321	0.948	0.8321	1	0.68053	1	0.47364	0.973	0.52019	1
ABCA7	9 (2%)	504	NA	NA	NA	NA	0.70218	1	0.38751	0.914	0.22498	0.732	0.17103	0.651	0.26519	0.791	0.21256	0.719	1	1	0.055339	0.315	0.098909	0.468	0.25194	0.768
NKD2	4 (1%)	509	NA	NA	NA	NA	1	1	0.87816	1	NA	NA	NA	NA	0.64179	1	0.46251	0.965	0.36784	0.894	1	1	1	1	0.83877	1
MAX	4 (1%)	509	NA	NA	NA	NA	0.12318	0.531	0.090659	0.444	0.23345	0.742	0.53718	1	0.18429	0.671	0.15745	0.629	0.30592	0.83	0.82969	1	0.33454	0.839	0.76092	1
VSIG4	6 (1%)	507	NA	NA	NA	NA	0.20703	0.714	0.1691	0.65	0.45901	0.964	0.74924	1	0.76911	1	0.50068	0.997	0.76448	1	0.58338	1	0.69386	1	0.39187	0.914
