rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(1), PGLYRP2(3)	890560	4	4	4	0	1	1	1	0	1	0	0.327	0.00219	0.823
2	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYC(1), RB1(2), SP1(2), SP3(3)	3297294	8	8	8	0	1	3	1	1	2	0	0.170	0.00267	0.823
3	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ3(2), COQ5(1), COQ7(1), NDUFA13(1)	1961734	5	5	5	0	0	2	0	2	1	0	0.269	0.00795	1.000
4	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	11	AKT1(3), GH1(1), GHR(2), IGF1R(2), SHC1(1), SOD3(1)	5269377	10	10	9	0	2	4	2	2	0	0	0.0698	0.00827	1.000
5	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(2), SDHA(1), SDHB(1), SDHC(2), UQCRC1(1)	3258606	7	7	7	0	1	2	0	1	3	0	0.189	0.0155	1.000
6	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(2), EGF(2), EGFR(4), TF(2)	6338332	10	10	10	1	4	2	1	3	0	0	0.266	0.0157	1.000
7	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(2), EGFR(4), ERBB3(2), UBE2D1(1)	5068951	9	9	9	1	3	0	1	4	1	0	0.296	0.0166	1.000
8	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	14	AKT1(3), EGFR(4), IGF1R(2), PRKCA(1), RB1(2), TEP1(4), TNKS(2), XRCC5(1)	13442481	19	19	18	1	6	4	3	6	0	0	0.0274	0.0189	1.000
9	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(3), ACAA2(1), ACAT1(1), EHHADH(5)	4121609	10	8	10	1	3	1	1	2	3	0	0.267	0.0198	1.000
10	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(1), EXT2(4), EXTL1(1), EXTL3(1), HS6ST1(1), HS6ST2(1), NDST2(2), NDST4(4)	10133977	15	15	15	1	1	7	0	5	2	0	0.0826	0.0220	1.000
11	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	NR1I3(2), PTGS1(2), PTGS2(2)	2640607	6	6	6	0	1	4	0	0	1	0	0.142	0.0257	1.000
12	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(2), ARHGEF1(2), GNA12(1), GNA13(1), MYLK(3), PLCB1(3), PRKCA(1), ROCK1(4)	10184546	17	17	16	2	3	4	2	6	2	0	0.223	0.0312	1.000
13	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	13	AKT1(3), BAD(1), GH1(1), GHR(2), NFKB1(2), RELA(2)	5857718	11	11	10	1	5	3	2	1	0	0	0.195	0.0321	1.000
14	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	6	SP1(2), SP3(3)	3069111	5	5	5	0	0	2	1	0	2	0	0.334	0.0479	1.000
15	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	NFKB1(2), PLCB1(3), PRKCA(1), RELA(2)	4046992	8	8	8	0	3	3	0	2	0	0	0.0984	0.0497	1.000
16	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	F13B(3), HSD17B4(1), HSD3B1(1), HSD3B2(1)	3991688	6	6	6	0	0	0	1	2	3	0	0.284	0.0516	1.000
17	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOC(2), GPI(1), PFKL(2), PFKM(2), PFKP(2), PGM3(1), PRPS1L1(3), RBKS(1), RPE(1), TKT(1)	11958051	16	16	16	2	2	3	1	6	4	0	0.189	0.0525	1.000
18	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	DCN(1), KERA(2)	1770834	3	3	3	1	0	0	2	0	1	0	0.888	0.0561	1.000
19	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	CHAT(2), DBH(2), DDC(1), GAD1(1), GAD2(3), HDC(1), MAOA(1), TPH1(1)	7059830	12	12	12	2	1	3	1	4	3	0	0.414	0.0668	1.000
20	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(1), EHHADH(5), SDHB(1)	3844398	7	6	7	1	2	2	1	0	2	0	0.483	0.0775	1.000
21	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOC(2), GPI(1), PFKM(2), PFKP(2), PGM3(1), PRPS1L1(3), RBKS(1), RPE(1), TKT(1)	10059450	14	14	14	2	2	3	1	6	2	0	0.269	0.0802	1.000
22	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	ALDOC(2), GCK(1), GMPPB(1), HK2(1), HK3(1), PFKFB1(1), PFKFB4(1), PFKM(2), PFKP(2), PMM1(1), TPI1(1)	11701759	14	14	14	1	2	2	2	5	3	0	0.0996	0.0853	1.000
23	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	DHRS1(1), DHRS7(1), DHRSX(1), PON1(1), PON2(2), PON3(1)	4430596	7	7	7	0	1	1	1	4	0	0	0.176	0.0881	1.000
24	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX15(2), ALOX5AP(1), LTC4S(1), PLA2G2A(1), PTGS1(2), PTGS2(2), TBXAS1(1)	7370397	10	10	10	0	2	5	2	0	1	0	0.0430	0.103	1.000
25	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(1), HMGCL(2)	1673620	3	3	3	1	0	1	1	0	1	0	0.807	0.105	1.000
26	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(1), ALDH1A2(2)	1923120	3	3	3	0	0	2	1	0	0	0	0.453	0.105	1.000
27	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(3), IL4R(3), IRS1(2), JAK1(2), JAK3(2), SHC1(1)	7238601	13	12	12	2	1	3	3	3	3	0	0.362	0.110	1.000
28	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	EHHADH(5)	2376418	5	4	5	0	2	1	0	0	2	0	0.325	0.118	1.000
29	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(2)	1000074	2	2	2	1	0	1	0	1	0	0	0.867	0.118	1.000
30	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(1), ATIC(3), DHFR(1), FTCD(1), GART(1), MTHFD1(1), MTHFD1L(1), MTHFR(2), MTR(1), SHMT2(1), TYMS(1)	9340808	14	14	14	2	2	7	0	1	4	0	0.240	0.125	1.000
31	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	18	ADCY1(1), ARHGEF1(2), F2(1), F2R(1), GNA12(1), GNA13(1), MAP3K7(1), PLCB1(3), PRKCA(1), ROCK1(4)	11614208	16	16	15	2	4	3	1	5	3	0	0.243	0.138	1.000
32	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(3), BAD(1), BTK(1), EEA1(2), LYN(1), PFKL(2), PFKM(2), PFKP(2), RAC1(1), VAV2(2)	12314219	17	15	16	3	4	6	2	2	3	0	0.214	0.140	1.000
33	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDOC(2), TPI1(1)	1924683	3	3	3	1	1	0	1	1	0	0	0.784	0.140	1.000
34	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CSF1R(2), EGF(2), EGFR(4), MET(3), PRKCA(1), SH3GLB2(1)	9567310	13	12	13	2	4	0	1	8	0	0	0.295	0.141	1.000
35	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	GAD1(1), GAD2(3)	2829624	4	4	4	1	0	1	1	1	1	0	0.776	0.141	1.000
36	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	10	AKT1(3), KLK2(1), NTRK1(1), PRKCA(1), SHC1(1)	6380810	7	7	6	1	0	3	1	1	2	0	0.565	0.144	1.000
37	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	MTMR2(1), MTMR6(1), THTPA(2)	3152669	4	4	4	1	0	2	0	2	0	0	0.684	0.157	1.000
38	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	ALDOC(2), GMPPB(1), HK2(1), HK3(1), MTMR2(1), MTMR6(1), PFKFB1(1), PFKFB4(1), PFKL(2), PFKM(2), PFKP(2), PGM2(1), PMM1(1), TPI1(1), TSTA3(1)	18186292	19	18	19	2	3	3	2	7	4	0	0.0959	0.158	1.000
39	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CYP11B2(1), HSD11B1(1), HSD3B1(1), HSD3B2(1)	3402096	4	4	4	0	0	0	0	1	3	0	0.314	0.165	1.000
40	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(2), GAD1(1), HDC(1), TPH1(1)	2967303	5	5	5	0	1	1	0	3	0	0	0.274	0.165	1.000
41	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	15	AKT1(3), NFKB1(2), RB1(2), RELA(2), SP1(2)	8469116	11	10	10	1	3	4	1	2	1	0	0.197	0.169	1.000
42	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(1), ATIC(3), DHFR(1), GART(1), MTHFD1(1), MTHFD1L(1), MTHFR(2), MTR(1), SHMT2(1), TYMS(1)	8836757	13	13	13	2	2	7	0	1	3	0	0.263	0.173	1.000
43	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), EHHADH(5)	5971516	10	8	10	2	3	3	1	1	2	0	0.468	0.176	1.000
44	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	PARK2(1), SNCAIP(2), UBE2L3(1)	3171568	4	4	4	0	0	1	3	0	0	0	0.495	0.183	1.000
45	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(2), ENPP1(2), ENPP3(1), NMNAT1(1), NNT(3), NT5E(1)	7164398	10	9	10	1	3	2	0	3	2	0	0.240	0.190	1.000
46	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	EPN1(1), EPS15(2), NME1(1), PICALM(1), PPP3CA(1), PPP3CC(1), SYNJ1(1), SYNJ2(2), SYT1(1)	10691275	11	11	11	1	1	1	1	6	2	0	0.238	0.192	1.000
47	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	AOC2(2), CES1(3)	2955227	5	4	5	1	3	0	2	0	0	0	0.496	0.194	1.000
48	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	19	AKT1(3), BAD(1), NFKB1(2), RAC1(1), RALGDS(1), RELA(2)	8019766	10	10	9	1	3	4	1	2	0	0	0.204	0.205	1.000
49	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(1), AASDH(1), AASDHPPT(1), AASS(1)	3429471	4	4	4	1	1	0	0	3	0	0	0.667	0.211	1.000
50	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	CFL1(1), CFLAR(1)	1909680	2	2	2	0	0	1	0	0	1	0	0.730	0.213	1.000
51	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL4R(3), JAK1(2), TYK2(1)	5175873	7	6	7	0	0	0	1	3	3	0	0.231	0.215	1.000
52	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL4R(3), JAK1(2), TYK2(1)	5175873	7	6	7	0	0	0	1	3	3	0	0.231	0.215	1.000
53	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ACADSB(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), AOC2(2), CNDP1(1), DPYD(4), EHHADH(5), GAD1(1), GAD2(3)	14310081	22	19	22	3	6	6	2	4	4	0	0.151	0.222	1.000
54	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	SEC61A2(1), SRP19(1), SRP54(2), SRPR(2)	3727610	6	5	5	0	3	1	0	1	1	0	0.243	0.224	1.000
55	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	23	BMPR1B(1), EGR1(1), INHA(1), LHCGR(1), MSH5(1), NCOR1(6), NRIP1(2), PGR(2), PRLR(2)	13983968	17	16	17	2	2	3	0	4	8	0	0.204	0.226	1.000
56	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(1), AASDHPPT(1), AASS(1)	2320434	3	3	3	1	1	0	0	2	0	0	0.765	0.230	1.000
57	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	EPX(1), MPO(1), MTHFR(2), SHMT2(1), TPO(1)	5715637	6	6	6	1	0	4	1	0	1	0	0.365	0.237	1.000
58	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(2), CYR61(1), EIF4E(1), NR4A3(1)	5296783	5	5	5	0	0	2	0	3	0	0	0.282	0.240	1.000
59	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(1)	356311	1	1	1	0	1	0	0	0	0	0	0.739	0.244	1.000
60	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ENO1(2), GPI(1), PFKL(2), PGK1(1), TPI1(1)	4547116	7	6	7	2	3	0	0	0	4	0	0.522	0.245	1.000
61	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(1), CS(2), PC(1), SLC25A11(1)	4544204	5	5	5	0	1	0	1	2	1	0	0.253	0.246	1.000
62	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	CS(2), PC(1), PDHX(1), PDK1(1), PDK2(1), PDK3(1), PDK4(1), PDP2(1), SDHA(1), SDHB(1), SDHC(2), SUCLG1(1)	13936051	14	13	14	1	1	4	2	3	4	0	0.140	0.249	1.000
63	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	21	ADCY1(1), AKT1(3), ITGAV(1), PLCB1(3), PRKCA(1), RAC1(1), SMPD2(2)	12437429	12	12	11	1	2	6	1	3	0	0	0.144	0.250	1.000
64	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT1(1), ACOT11(1), DHRS1(1), DHRS7(1), DHRSX(1), EHHADH(5), ESCO1(4), ESCO2(1)	12795882	15	13	15	1	6	3	1	1	4	0	0.108	0.250	1.000
65	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(1), ACPT(1), ENPP1(2), ENPP3(1), RFK(1)	4786437	6	6	6	0	2	0	0	2	2	0	0.198	0.258	1.000
66	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	CYP11B2(1), CYP21A2(1), HSD11B1(1), HSD3B1(1), HSD3B2(1)	4535581	5	5	5	0	1	0	0	1	3	0	0.229	0.260	1.000
67	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	CYP11B2(1), CYP21A2(1), HSD11B1(1), HSD3B1(1), HSD3B2(1)	4535581	5	5	5	0	1	0	0	1	3	0	0.229	0.260	1.000
68	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(1), PAPSS2(1), SULT1E1(1), SUOX(1)	3013654	4	4	4	0	1	1	0	1	1	0	0.342	0.265	1.000
69	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	EHHADH(5), HSD17B4(1), SIRT1(1)	5819258	7	6	7	1	2	1	0	1	3	0	0.495	0.276	1.000
70	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	16	ADRB2(1), AKT1(3), NFKB1(2), NOS3(2), RELA(2), SYT1(1)	7672404	11	10	10	2	4	4	2	1	0	0	0.375	0.285	1.000
71	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	19	AKT1(3), NFKB1(2), RAC1(1), RB1(2), RELA(2), TFDP1(1)	8446614	11	9	10	1	3	3	1	4	0	0	0.171	0.287	1.000
72	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(1), ACPT(1), ENPP1(2), ENPP3(1), MTMR2(1), MTMR6(1), RFK(1)	7416865	8	8	8	1	2	1	0	3	2	0	0.349	0.292	1.000
73	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(1), IL12A(1)	1477864	2	2	2	1	0	1	0	0	1	0	0.866	0.304	1.000
74	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMPR1A(1), BMPR1B(1), BMPR2(1)	3078847	3	3	3	0	0	1	0	1	1	0	0.591	0.313	1.000
75	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	NFATC2(1), NFATC4(1), PPP3CA(1), PPP3CC(1), PRKCA(1), SP1(2), SP3(3), SYT1(1)	10328225	11	10	11	1	3	2	2	2	2	0	0.199	0.316	1.000
76	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	DPYD(4), ENPP1(2), ENPP3(1), PANK1(1)	6866362	8	8	8	1	4	1	0	2	1	0	0.321	0.325	1.000
77	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	DAG1(2), ITPKB(1)	2975533	3	3	3	0	0	2	1	0	0	0	0.415	0.326	1.000
78	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNB1(1), IL12A(1), IL16(2), IL9(1), LTA(1)	4910173	6	6	6	1	1	1	0	2	2	0	0.557	0.329	1.000
79	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	ARSB(2), ARSD(1), ARSE(1), CYP11B2(1), HSD11B1(1), HSD3B1(1), HSD3B2(1), STS(1), SULT1E1(1), UGT1A1(2), UGT1A3(1), UGT1A7(1), UGT2B15(3)	13416124	17	14	17	3	4	2	0	6	5	0	0.244	0.332	1.000
80	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	13	AKT1(3), BAD(1), IGF1R(2), IRS1(2), SHC1(1)	8070436	9	8	8	1	1	3	1	3	1	0	0.327	0.336	1.000
81	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	20	AKT1(3), EIF4E(1), EIF4G1(3), GHR(2), IRS1(2), PDK2(1), PRKCA(1)	12394804	13	12	12	0	3	3	1	4	2	0	0.0531	0.337	1.000
82	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	11	CREBBP(2), DAXX(1), PAX3(1), RB1(2), SIRT1(1), SP100(1)	8738884	8	8	8	1	2	0	1	5	0	0	0.389	0.351	1.000
83	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(1), BAD(1), BCL2L11(1), CES1(3)	5284666	6	6	6	0	2	1	2	1	0	0	0.245	0.358	1.000
84	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(1), ACOX3(1), FADS2(1), PLA2G2A(1), PLA2G4A(1)	4976179	5	5	5	1	1	1	1	1	1	0	0.587	0.360	1.000
85	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS1(1), DHRS7(1), DHRSX(1), ESCO1(4), ESCO2(1)	8169443	8	8	8	0	3	2	0	1	2	0	0.137	0.363	1.000
86	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIPT1(1)	756907	1	1	1	0	0	1	0	0	0	0	0.809	0.370	1.000
87	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	17	AKT1(3), EIF4E(1), IGF1R(2), INPPL1(1), PDK2(1)	8208908	8	8	7	1	1	2	1	4	0	0	0.385	0.371	1.000
88	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	BPNT1(1), CHST12(1), PAPSS2(1), SULT1E1(1), SUOX(1)	4539998	5	5	5	0	1	1	0	2	1	0	0.279	0.376	1.000
89	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	NFKB1(2), RELA(2), TNFRSF13B(2), TRAF2(1)	7128577	7	7	7	1	4	2	0	1	0	0	0.363	0.388	1.000
90	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	B2M(1), CD74(1), CD8A(1), CD8B(1), CIITA(1), HLA-DMB(1), HLA-DQA2(1), HLA-G(1), HSP90AA1(2), HSP90AB1(1), HSPA5(2), IFI30(1), IFNA10(1), IFNA13(1), IFNA16(2), IFNA17(1), IFNA21(1), IFNA6(1), KIR3DL1(2), LTA(1), NFYC(1), PSME2(1), RFXAP(1)	22782062	27	22	27	4	7	5	2	4	9	0	0.159	0.401	1.000
91	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), XYLT1(2)	3179774	3	3	3	1	0	1	1	0	1	0	0.881	0.405	1.000
92	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), XYLT1(2)	3179774	3	3	3	1	0	1	1	0	1	0	0.881	0.405	1.000
93	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOC(2), GOT2(1), GPT(1), ME3(1), PGK1(1), PGK2(1), RPE(1), TKT(1), TPI1(1)	9913368	10	10	10	0	3	1	1	4	1	0	0.0519	0.405	1.000
94	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BAD(1), MAP2K4(2), NFKB1(2), NSMAF(2), RELA(2), TRAF2(1)	10064369	10	10	10	0	4	4	0	2	0	0	0.0505	0.413	1.000
95	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	14	NFKB1(2), PLCB1(3), PRKCA(1), RELA(2)	7434304	8	8	8	1	3	3	0	2	0	0	0.249	0.413	1.000
96	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR3(1), ARHGAP5(2), ARHGAP6(1), ARHGEF1(2), ARHGEF11(2), ARHGEF5(2), ARPC4(1), CFL1(1), LIMK1(1), MYLK(3), PFN1(1), PIP5K1A(1), ROCK1(4), TLN1(2)	22138347	24	22	23	3	3	5	3	5	8	0	0.191	0.419	1.000
97	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOC(2), GOT2(1), GPT(1), ME3(1), PGK1(1), RPE(1), TKT(1), TPI1(1)	8860419	9	9	9	0	3	1	1	3	1	0	0.0678	0.425	1.000
98	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(2), ENPP1(2), ENPP3(1), NADK(2), NMNAT1(1), NNT(3), NT5E(1), NUDT12(2)	10609429	14	10	14	2	4	3	0	3	4	0	0.277	0.426	1.000
99	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT2(1)	1286413	1	1	1	0	0	1	0	0	0	0	0.726	0.427	1.000
100	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	29	ANPEP(1), GSTA2(2), GSTA3(1), GSTM2(1), GSTM3(1), GSTO2(1)	8468871	7	7	7	1	1	2	1	3	0	0	0.410	0.431	1.000
101	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	18	AKT1(3), APAF1(1), BAD(1), PRKCA(1), STAT1(1), TLN1(2)	10022914	9	9	8	1	1	3	2	2	1	0	0.297	0.436	1.000
102	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(2), FUCA2(1), HEXB(2), LCT(1), MAN2B1(2), MAN2B2(1), MAN2C1(1), NEU4(1)	10030126	11	10	11	2	2	5	0	2	2	0	0.338	0.438	1.000
103	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	CA12(1), CA14(1), CA2(2), CA3(1), CA5A(1), CA6(1), CA8(1), CA9(1), CPS1(2), GLUL(1), HAL(1)	9362483	13	13	13	3	1	5	1	3	3	0	0.456	0.438	1.000
104	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNB1(1), JAK1(2), STAT1(1), STAT2(1), TYK2(1)	5342351	6	5	6	1	1	0	0	2	3	0	0.641	0.440	1.000
105	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ERBB4(2), NRG2(1), PRKCA(1)	4442513	4	4	4	1	1	1	0	2	0	0	0.707	0.441	1.000
106	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	14	ABL1(1), POLR1A(2), POLR1B(1), POLR1C(1), RAC1(1), RB1(2)	8535365	8	8	8	0	3	0	1	4	0	0	0.126	0.453	1.000
107	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1)	3924876	5	4	5	2	1	2	1	1	0	0	0.776	0.454	1.000
108	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1)	3924876	5	4	5	2	1	2	1	1	0	0	0.776	0.454	1.000
109	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	TPI1(1)	810274	1	1	1	1	1	0	0	0	0	0	0.925	0.459	1.000
110	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(2), GNA12(1), PRKAG1(2)	4968569	5	5	5	0	2	0	1	2	0	0	0.286	0.466	1.000
111	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(1), GOT2(1)	2308555	2	2	2	1	0	1	0	0	1	0	0.792	0.466	1.000
112	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(1), PLCB1(3)	3532231	4	4	4	1	2	2	0	0	0	0	0.593	0.470	1.000
113	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(1), CS(2), HAO1(1), MTHFD1(1), MTHFD1L(1)	6313639	6	6	6	0	1	3	0	2	0	0	0.176	0.472	1.000
114	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(1), HSD17B4(1), MECR(1)	4159674	3	3	3	1	0	1	0	1	1	0	0.760	0.473	1.000
115	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	6	AKT1(3), PLCB1(3), PRKCA(1)	5245247	7	7	6	2	1	4	1	1	0	0	0.674	0.479	1.000
116	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	ALOX15(2), CYP4F2(1), CYP4F3(1), EPX(1), MPO(1), PLA2G2A(1), PLA2G4A(1), PTGS1(2), PTGS2(2), TBXAS1(1), TPO(1)	13686542	14	14	14	2	2	7	4	0	1	0	0.171	0.479	1.000
117	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	ALOX12B(1), ALOX15(2), CYP2B6(2), CYP2C19(2), CYP2C8(2), CYP2J2(1), CYP4F2(1), CYP4F3(1), LTC4S(1), PLA2G2A(1), PLA2G4A(1), PTGS1(2), PTGS2(2), TBXAS1(1)	19112755	20	20	20	3	2	7	4	4	3	0	0.179	0.480	1.000
118	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	8	MMP2(1), MMP9(2)	3472773	3	3	3	1	2	0	1	0	0	0	0.713	0.482	1.000
119	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	KEAP1(2), PRKCA(1)	4348277	3	3	3	1	1	1	0	1	0	0	0.706	0.484	1.000
120	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	IFNB1(1), NFKB1(2), RELA(2)	5442661	5	5	5	0	2	1	0	1	1	0	0.302	0.485	1.000
121	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BIRC2(1), CFLAR(1), MAP2K4(2), MAP3K3(1), MAP3K7(1), NFKB1(2), NFKBIB(1), TNFAIP3(1), TRAF2(1)	13364486	11	11	11	1	3	4	1	1	2	0	0.183	0.485	1.000
122	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ALDH1A3(1), ALDH1B1(1), AOC2(2), CNDP1(1), DPYD(4), EHHADH(5), GAD1(1), GAD2(3)	13288318	18	16	18	3	6	4	1	4	3	0	0.267	0.488	1.000
123	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(2), EGFR(4)	8453084	6	6	6	0	2	0	1	3	0	0	0.225	0.500	1.000
124	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCR1(1), CCR2(3), CCR4(1), IL12A(1), IL12RB2(1), IL4R(3)	9785701	10	9	10	1	3	2	2	1	2	0	0.184	0.501	1.000
125	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	15	AKT1(3), MEF2C(1), NTRK1(1), SHC1(1)	8008779	6	6	5	1	0	3	1	1	1	0	0.532	0.503	1.000
126	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	32	AKT1(3), APC(2), CCL15(1), DAG1(2), EGFR(4), ITPKB(1), ITPR1(1), ITPR2(5), MAPK10(1), PIK3CD(2)	24362937	22	21	21	3	5	6	3	3	5	0	0.147	0.509	1.000
127	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	63	AGPAT2(1), AGPAT3(1), AGPAT4(1), CDS1(1), CHAT(2), DGKD(3), DGKI(4), DGKQ(1), DGKZ(1), ESCO1(4), ESCO2(1), GNPAT(1), GPD1(1), PLA2G2A(1), PLA2G4A(1), PLD1(2), PPAP2A(1), PTDSS1(1)	32036902	28	26	28	2	2	7	5	4	10	0	0.0307	0.509	1.000
128	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(1), CS(2), HAO1(1), MTHFD1(1), MTHFD1L(1)	6610809	6	6	6	0	1	3	0	2	0	0	0.175	0.516	1.000
129	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(1), HDAC9(1), MEF2C(1)	3749643	3	3	3	1	0	0	1	2	0	0	0.814	0.518	1.000
130	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(1), PSMA2(1), PSMA6(1)	4314925	3	3	3	0	1	2	0	0	0	0	0.397	0.532	1.000
131	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(1), MPO(1), TPO(1)	4100566	3	3	3	0	0	2	1	0	0	0	0.410	0.536	1.000
132	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(1), PRKCA(1)	2416383	2	2	2	0	0	0	0	1	1	0	0.864	0.536	1.000
133	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(2), AGTR1(1), NOS3(2)	4801110	5	5	5	0	2	2	0	1	0	0	0.179	0.544	1.000
134	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F2(1), F2R(1), F3(1), F5(4), FGA(4), FGB(1), PROC(1), PROS1(2)	8083283	15	15	15	4	4	3	3	4	1	0	0.641	0.547	1.000
135	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH4(1), ADHFE1(1)	2789302	2	2	2	0	0	1	0	1	0	0	0.581	0.547	1.000
136	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CDC34(1), RB1(2), TFDP1(1)	4071151	4	4	4	0	2	0	0	2	0	0	0.348	0.556	1.000
137	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	8	NFKB1(2), RELA(2)	4381757	4	4	4	1	2	1	0	1	0	0	0.652	0.558	1.000
138	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	CRY1(1), NPAS2(1), PER1(2), PER2(1), PER3(3)	8400979	8	7	8	1	3	4	0	0	1	0	0.270	0.560	1.000
139	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(2), JAK3(2), STAT3(3), TYK2(1)	5764681	8	7	8	2	2	0	1	3	2	0	0.696	0.560	1.000
140	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(2), MAP2(4), PPP1CA(1), PRKAG1(2)	8969268	9	9	9	2	1	1	1	5	1	0	0.562	0.561	1.000
141	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA3(2)	2942673	2	2	2	0	0	1	1	0	0	0	0.518	0.563	1.000
142	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA2(1), ANXA4(1), ANXA6(2), HSD11B1(1), PLA2G4A(1), PTGS1(2), PTGS2(2), SCGB1A1(1), TBXAS1(1)	10203130	12	12	12	3	1	3	3	2	3	0	0.541	0.570	1.000
143	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNB1(1), JAK1(2), STAT1(1), STAT2(1), TYK2(1)	6160881	6	5	6	1	1	0	0	2	3	0	0.639	0.573	1.000
144	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	CNR1(1), DNMT1(3), MTNR1B(1), PTAFR(1)	5497433	6	5	6	0	3	3	0	0	0	0	0.0818	0.578	1.000
145	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CDC34(1), RB1(2), TFDP1(1)	4203209	4	4	4	1	2	0	0	2	0	0	0.674	0.583	1.000
146	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	EPX(1), MPO(1), SHMT2(1), TPO(1)	5804252	4	4	4	1	0	2	1	0	1	0	0.574	0.587	1.000
147	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(1), PPARG(1)	2860956	2	2	2	0	0	0	0	1	1	0	0.582	0.589	1.000
148	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(1), GPR171(1), GPR75(1)	4836125	3	3	3	0	0	1	1	1	0	0	0.462	0.590	1.000
149	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(2), GALNS(1), HEXB(2), LCT(1), NAGLU(1)	7021415	7	6	7	1	2	3	0	1	1	0	0.402	0.591	1.000
150	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(2), FUCA2(1), HEXB(2), LCT(1), MAN2C1(1), NEU4(1)	8137119	8	7	8	2	2	2	0	2	2	0	0.583	0.592	1.000
151	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	HEMK1(1), METTL6(1), PRMT3(2), PRMT5(2)	6884541	6	6	6	4	0	1	0	1	4	0	0.942	0.594	1.000
152	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	11	RB1(2), TFDP1(1)	4022064	3	3	3	0	1	0	0	2	0	0	0.476	0.598	1.000
153	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	17	AKT1(3), HSPA1A(1), NFKBIB(1)	6732387	5	5	4	0	1	3	1	0	0	0	0.252	0.600	1.000
154	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	ACAT1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), EHHADH(5), GAD1(1), GAD2(3), HMGCL(2), SDHB(1)	12697651	18	15	18	4	3	6	3	2	4	0	0.463	0.601	1.000
155	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	DUSP1(1), IKBKAP(1), LTA(1), NFKB1(2), RELA(2), TANK(1), TNFAIP3(1), TRAF2(1)	11017878	10	9	10	1	4	3	0	2	1	0	0.198	0.611	1.000
156	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(1), HK2(1), HK3(1), PGM3(1)	5032384	4	4	4	0	1	0	1	1	1	0	0.383	0.611	1.000
157	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOC(2), ENO1(2), GCK(1), GOT2(1), GPI(1), HK2(1), HK3(1), PC(1), PDHX(1), PFKL(2), PFKM(2), PFKP(2), PGK1(1), PGK2(1), TPI1(1)	20892986	20	19	20	3	4	4	3	3	6	0	0.130	0.618	1.000
158	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	ITGAL(2), ITGAM(1), ITGB2(1), SELE(2)	5080535	6	6	6	2	2	3	0	1	0	0	0.648	0.618	1.000
159	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(2), GOT2(1)	4087765	3	3	3	0	1	1	0	0	1	0	0.400	0.621	1.000
160	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARFGEF2(1), COPA(3), GBF1(2), KDELR3(1)	8006623	7	6	7	1	2	2	1	1	1	0	0.398	0.623	1.000
161	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	26	ACLY(1), ACO1(1), CS(2), PC(1), PCK2(1), SDHA(1), SDHB(1), SDHC(2), SUCLG1(1)	14265388	11	10	11	1	2	1	1	3	4	0	0.200	0.624	1.000
162	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(1), MPO(1), TPO(1)	4737717	3	3	3	0	0	2	1	0	0	0	0.418	0.632	1.000
163	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	GCK(1), HEXB(2), HK2(1), HK3(1), PGM3(1)	8323629	6	6	6	1	1	1	1	1	2	0	0.572	0.637	1.000
164	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	RPE(1), UGT1A1(2), UGT1A3(1), UGT1A7(1), UGT2A3(1), UGT2B11(2), UGT2B15(3), UGT2B28(1), UGT2B7(1)	13456900	13	10	13	2	5	1	2	4	1	0	0.279	0.638	1.000
165	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	DRD2(1), GRM1(4), PLCB1(3), PPP1CA(1), PPP3CA(1)	7901111	10	10	10	3	3	5	0	2	0	0	0.533	0.642	1.000
166	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	ALOX15(2), CYP2C19(2), CYP2C8(2), CYP2J2(1), CYP3A43(2), PLA2G2A(1), PLA2G4A(1)	11774026	11	11	11	2	2	2	2	2	3	0	0.417	0.642	1.000
167	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(1), AOC2(2), CES1(3), DDHD1(2), ESCO1(4), ESCO2(1)	12446979	13	11	13	2	5	1	3	2	2	0	0.348	0.643	1.000
168	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	CRY1(1), PER1(2)	4169325	3	3	3	1	2	1	0	0	0	0	0.730	0.644	1.000
169	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACAA1(3), ACOX1(1), ACOX3(1), FADS2(1), FASN(1), PECR(1)	6974104	8	7	8	2	3	0	2	2	1	0	0.549	0.644	1.000
170	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	GRIN1(1), NFKB1(2), RELA(2)	6231374	5	5	5	1	2	1	0	2	0	0	0.549	0.648	1.000
171	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	35	ANPEP(1), GSTA2(2), GSTA3(1), GSTM2(1), GSTM3(1), GSTO2(1)	10410292	7	7	7	1	1	2	1	3	0	0	0.404	0.649	1.000
172	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	NFKB1(2), RELA(2)	4850208	4	4	4	1	2	1	0	1	0	0	0.580	0.657	1.000
173	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	13	AKT1(3), PDK2(1), SHC1(1)	7808023	5	5	4	1	0	3	1	1	0	0	0.579	0.657	1.000
174	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	DHRS1(1), DHRS7(1), DHRSX(1), HEMK1(1), METTL6(1), PRMT3(2), PRMT5(2)	7390907	9	9	9	4	1	2	0	2	4	0	0.811	0.657	1.000
175	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	13	AKT1(3), NTRK1(1), PIK3CD(2), SHC1(1)	6602866	7	7	6	2	0	4	1	0	2	0	0.619	0.658	1.000
176	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(1), PSMA2(1), PSMA6(1), PSMD2(1), PSMD6(1)	7904895	5	5	5	0	1	3	0	1	0	0	0.243	0.659	1.000
177	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(2), DYRK1B(1), GLI2(2), GLI3(2), SHH(1)	8191454	8	8	8	2	0	5	0	3	0	0	0.533	0.662	1.000
178	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	PDE1B(1), PLCB1(3)	5473864	4	4	4	0	1	2	0	1	0	0	0.297	0.665	1.000
179	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	12	AKT1(3), BAD(1), MUSK(1)	6907192	5	5	4	0	1	2	2	0	0	0	0.233	0.669	1.000
180	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	SHMT2(1)	2044131	1	1	1	1	0	0	0	0	1	0	0.893	0.670	1.000
181	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ADH4(1), ADHFE1(1), DHRS1(1), DHRS7(1), DHRSX(1), ESCO1(4), ESCO2(1)	12303315	10	9	10	0	3	3	0	2	2	0	0.0786	0.670	1.000
182	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	19	AKT1(3), EIF4E(1), EIF4G1(3), PDK2(1), TSC2(1)	12123920	9	9	8	0	1	4	1	2	1	0	0.119	0.672	1.000
183	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	10	ACLY(1), ACO1(1), ACSS1(2), ACSS2(1)	6119225	5	5	5	0	3	1	0	0	1	0	0.174	0.677	1.000
184	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	DUSP1(1), IKBKAP(1), NFKB1(2), RELA(2), TNFAIP3(1)	8896606	7	7	7	1	2	3	0	1	1	0	0.389	0.678	1.000
185	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAS1(1), ALAS2(1), HMBS(1)	3667461	3	3	3	1	2	0	1	0	0	0	0.745	0.681	1.000
186	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP1(1), ACPT(1), ALPP(2), CYP3A43(2), DHRS1(1), DHRS7(1), DHRSX(1), PON1(1), PON2(2), PON3(1)	8883597	13	13	13	4	2	3	2	5	1	0	0.586	0.683	1.000
187	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(1), EIF4E(1), FBL(1), GPT(1)	4405972	4	3	4	1	2	1	0	1	0	0	0.644	0.683	1.000
188	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	B4GALT2(1), GAA(1), GANAB(1), GCK(1), HK2(1), HK3(1), LCT(1), MGAM(2), PFKM(2), PFKP(2), PGM3(1)	15953445	14	11	14	2	3	3	2	3	3	0	0.245	0.685	1.000
189	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	28	EGFR(4), IGF1R(2), KLK2(1), PTPRR(1), RPS6KA5(2), SHC1(1), STAT3(3)	16008932	14	14	14	2	4	1	1	7	1	0	0.319	0.687	1.000
190	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	LDLR(1), NR1H3(1)	2687096	2	2	2	1	1	1	0	0	0	0	0.837	0.691	1.000
191	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	BCHE(2), CES1(3), UGT1A1(2), UGT1A3(1), UGT1A7(1)	11270070	9	8	9	1	3	1	2	1	2	0	0.278	0.691	1.000
192	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAS1(1), ALAS2(1), HBB(1), HMBS(1)	3750172	4	3	4	1	3	0	1	0	0	0	0.620	0.699	1.000
193	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(1), AGTR1(1), CMA1(1), COL4A1(1), COL4A2(2), COL4A4(2)	12275962	8	8	8	1	1	3	0	2	2	0	0.420	0.700	1.000
194	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLUD2(1)	2244243	1	1	1	0	0	1	0	0	0	0	0.751	0.709	1.000
195	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(1), GOT2(1)	3380751	2	2	2	0	0	2	0	0	0	0	0.558	0.711	1.000
196	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(1), HK2(1), HK3(1), PGM3(1)	5730797	4	4	4	0	1	0	1	1	1	0	0.379	0.712	1.000
197	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(1), IL22(1), JAK1(2), JAK3(2), STAT1(1), STAT3(3), STAT5A(1), STAT5B(1), TYK2(1)	9028839	13	11	13	3	3	2	1	5	2	0	0.540	0.713	1.000
198	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(1)	1603764	1	1	1	0	1	0	0	0	0	0	0.657	0.722	1.000
199	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	EHHADH(5), PECR(1), SLC25A20(1)	8296025	7	6	7	1	3	1	0	1	2	0	0.473	0.727	1.000
200	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(2)	2395489	2	2	2	2	0	0	0	1	1	0	0.978	0.734	1.000
201	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(1), MARS(1), MARS2(1), PAPSS2(1), SEPHS1(1)	6086327	5	4	5	1	2	2	0	1	0	0	0.466	0.737	1.000
202	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	CHAT(2)	3413045	2	2	2	0	0	1	0	1	0	0	0.575	0.738	1.000
203	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	IL5RA(1)	2634034	1	1	1	1	0	0	1	0	0	0	0.970	0.740	1.000
204	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	20	F2(1), F2R(1), ITGA1(1), PLA2G4A(1), PLCB1(3), PRKCA(1), PTGS1(2), SYK(2), TBXAS1(1)	11792545	13	13	13	3	2	7	1	2	1	0	0.418	0.743	1.000
205	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	15	ADAM12(3), EGF(2), EGFR(4), NFKB1(2), PRKCA(1), RELA(2)	9896749	14	13	14	4	6	2	1	5	0	0	0.529	0.744	1.000
206	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(1), GOT2(1), SULT4A1(2)	6182458	4	4	4	1	1	2	0	1	0	0	0.621	0.748	1.000
207	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNH(1), SHH(1)	4282988	2	2	2	1	0	0	0	2	0	0	0.883	0.749	1.000
208	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(2), ARSB(2), FUCA2(1), GALNS(1), HEXB(2), LCT(1), MAN2B1(2), MAN2B2(1), MAN2C1(1), NAGLU(1), NEU4(1), SPAM1(1)	16877655	16	15	16	3	3	7	1	3	2	0	0.290	0.750	1.000
209	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	CS(2), SDHA(1)	4633120	3	3	3	0	1	0	0	2	0	0	0.449	0.750	1.000
210	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	DHFR(1), POLG(1), RRM1(3)	6142170	5	4	5	0	2	1	0	0	2	0	0.309	0.752	1.000
211	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(1), LEPR(1), PRKAA2(2), PRKAG1(2), PRKAG2(1)	7150176	7	7	7	2	1	0	1	5	0	0	0.697	0.755	1.000
212	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(1), HMGCL(2), HMGCS1(2)	3544528	5	5	5	2	0	1	1	1	2	0	0.768	0.757	1.000
213	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	GRIA2(1)	1841514	1	1	1	1	1	0	0	0	0	0	0.914	0.757	1.000
214	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(1), ACTR3(1), ARPC4(1), RAC1(1), WASF1(1)	4006826	5	5	5	2	0	2	1	1	1	0	0.813	0.761	1.000
215	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	B4GALT2(1), G6PC2(1), GAA(1), GCK(1), HK2(1), HK3(1), LCT(1), MGAM(2), PFKL(2), PFKM(2), PFKP(2), PGM3(1)	18936220	16	14	16	3	3	3	2	4	4	0	0.279	0.761	1.000
216	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	DPYD(4), ENPP1(2), ENPP3(1), PANK1(1)	8528499	8	8	8	2	4	1	0	2	1	0	0.536	0.764	1.000
217	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD34(1), CD8A(1)	3052993	2	2	2	2	0	1	0	0	1	0	0.947	0.771	1.000
218	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD8A(1), IL7(1), IL9(1)	2993126	3	3	3	3	0	1	0	1	1	0	0.968	0.773	1.000
219	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	JAK1(2), STAT1(1)	4062228	3	2	3	1	0	0	0	2	1	0	0.807	0.776	1.000
220	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	JAK1(2), PLA2G2A(1), STAT1(1)	5668112	4	3	4	1	0	1	0	2	1	0	0.702	0.780	1.000
221	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	31	DUSP1(1), MAP2K4(2), MAPK10(1), MAPK9(1), MAPKAPK5(1), NFKB1(2), NFKBIB(1), PIK3CD(2), SYT1(1), TRAF2(1)	15431560	13	12	13	0	6	5	0	1	1	0	0.0111	0.780	1.000
222	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(1), PSMA2(1), PSMA6(1)	6357250	3	3	3	1	1	2	0	0	0	0	0.721	0.782	1.000
223	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2D(1), DAG1(2), ITPKB(1), ITPR1(1), ITPR2(5), PDE6C(1), TF(2)	17586625	13	13	13	2	2	5	2	2	2	0	0.351	0.783	1.000
224	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	CA12(1), CA14(1), CA2(2), CA3(1), CA5A(1), CA6(1), CA8(1), CA9(1), CPS1(2), GLUD2(1), GLUL(1), HAL(1)	10460630	14	14	14	4	1	6	1	3	3	0	0.563	0.784	1.000
225	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	RPE(1), UGT1A1(2), UGT1A3(1), UGT1A7(1), UGT2B15(3)	8666500	8	6	8	2	4	1	0	2	1	0	0.479	0.785	1.000
226	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	SHMT2(1)	2691562	1	1	1	1	0	0	0	0	1	0	0.903	0.785	1.000
227	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	JAK1(2), JAK3(2), PIAS3(1), STAT3(3)	7493719	8	7	8	2	2	0	1	4	1	0	0.680	0.786	1.000
228	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	17	EGF(2), EGFR(4), PTPRB(1), SHC1(1), SPRY3(1)	12075016	9	9	9	2	2	1	2	4	0	0	0.541	0.794	1.000
229	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	69	ADH4(1), ADHFE1(1), AKR1C1(1), ALDH1A3(1), CYP1A1(1), CYP2B6(2), CYP2C19(2), CYP2C8(2), CYP2S1(1), CYP3A43(2), EPHX1(1), GSTA2(2), GSTA3(1), GSTM2(1), GSTM3(1), GSTO2(1), UGT1A1(2), UGT1A3(1), UGT1A7(1), UGT2A3(1), UGT2B11(2), UGT2B15(3), UGT2B28(1), UGT2B7(1)	28278667	33	30	33	5	7	6	5	13	2	0	0.0974	0.803	1.000
230	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(1), CAMK2D(1), CLCA1(1), CLCA2(2), CLCA4(1), CNGA3(1), CNGA4(1), CNGB1(1), GUCA1A(1), PDE1C(1), PRKACA(1)	15008401	12	12	12	2	1	6	1	3	1	0	0.335	0.804	1.000
231	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	13	CFL1(1)	3545796	1	1	1	1	0	0	0	0	1	0	1.000	0.805	1.000
232	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	19	ACO1(1), CS(2), PC(1), SDHA(1), SDHB(1), SUCLG1(1)	9706933	7	6	7	0	2	1	1	2	1	0	0.161	0.805	1.000
233	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(1), ALDH1A3(1), ALDH1B1(1), CYP2C19(2), DHRS1(1), DHRS7(1), DHRSX(1), EHHADH(5), ESCO1(4), ESCO2(1)	15216224	18	16	18	3	7	4	0	3	4	0	0.262	0.805	1.000
234	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	9	TOP2A(1), TOP2B(1)	4402578	2	2	2	1	0	1	0	0	1	0	0.953	0.810	1.000
235	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	14	APAF1(1), RB1(2)	5437905	3	3	3	0	1	1	0	1	0	0	0.426	0.813	1.000
236	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	GABRA4(1), GPHN(1), UBQLN1(1)	5873875	3	3	3	0	1	0	1	1	0	0	0.480	0.815	1.000
237	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	JAK1(2), JAK3(2), PIAS3(1)	6763430	5	4	5	1	1	0	1	2	1	0	0.652	0.815	1.000
238	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPP(2), DHFR(1), SPR(1)	3204947	4	4	4	4	0	3	0	0	1	0	0.964	0.818	1.000
239	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA4(1)	3892632	1	1	1	0	0	0	1	0	0	0	0.849	0.822	1.000
240	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	LARS(1), LARS2(1)	4936247	2	2	2	0	1	0	0	1	0	0	0.591	0.827	1.000
241	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	24	AKT1(3), APC(2), CD14(1), LEF1(1), LY96(1), NFKB1(2), RELA(2)	13226272	12	12	11	3	2	5	1	2	2	0	0.501	0.828	1.000
242	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CAMK1(1), CAMK2D(1), SYT1(1)	5678528	3	3	3	0	1	0	1	1	0	0	0.486	0.833	1.000
243	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(1), DNMT1(3), DNMT3A(1), MARS(1), MARS2(1), MTR(1)	8548666	8	6	8	1	5	1	0	1	1	0	0.236	0.833	1.000
244	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(1), APAF1(1), DAXX(1), FAS(1), FASLG(1), MAPKAPK3(1)	5584717	6	6	6	5	0	1	1	2	2	0	0.993	0.833	1.000
245	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(2), GALNS(1), HEXB(2), LCT(1), NAGLU(1), SPAM1(1)	10019237	8	7	8	2	2	3	1	1	1	0	0.622	0.837	1.000
246	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	PRKCA(1)	3289206	1	1	1	0	0	0	0	1	0	0	0.857	0.838	1.000
247	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	NEK1(1)	3412059	1	1	1	0	0	1	0	0	0	0	0.786	0.839	1.000
248	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	BET1(1), GOSR1(1), STX10(1), STX16(1)	8196598	4	4	4	1	1	0	0	2	1	0	0.729	0.841	1.000
249	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	32	AGTR1(1), ATF2(2), EGFR(4), MAP2K4(2), MEF2C(1), PRKCA(1), RAC1(1), SHC1(1), SYT1(1)	16185663	14	14	14	3	3	2	2	7	0	0	0.429	0.841	1.000
250	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	8	ACO1(1), SDHB(1)	3970256	2	2	2	0	1	1	0	0	0	0	0.524	0.847	1.000
251	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(1), AMD1(1), DNMT1(3), DNMT3A(1), MARS(1), MARS2(1), MTR(1)	10177294	9	7	9	1	5	1	0	2	1	0	0.207	0.848	1.000
252	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDK(1)	2416459	1	1	1	1	1	0	0	0	0	0	0.936	0.848	1.000
253	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	CPS1(2)	3839921	2	2	2	2	0	1	0	0	1	0	0.956	0.860	1.000
254	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	17	HSPA1A(1), NFKB1(2), RB1(2), RELA(2)	8505266	7	5	7	0	4	1	0	2	0	0	0.125	0.864	1.000
255	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(1), AKT1(3), DAG1(2), ITPKB(1), ITPR1(1), ITPR2(5), NFKB1(2), NFKBIB(1), PDK1(1), PIK3CB(2), PLD1(2)	22059945	21	18	20	4	4	7	4	3	3	0	0.270	0.865	1.000
256	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	14	AKT1(3), BPNT1(1), PDK1(1), PIK3CD(2), RBL2(2), SHC1(1)	8564805	10	10	9	3	1	4	2	2	1	0	0.635	0.866	1.000
257	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	IL12A(1), IL12RB2(1), STAT4(3), TYK2(1)	7177382	6	6	6	2	1	0	1	2	2	0	0.772	0.866	1.000
258	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RANBP2(2)	4154217	2	1	2	1	0	1	0	0	1	0	0.962	0.869	1.000
259	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(1), CDC7(2), MCM2(1), MCM3(1), MCM4(1), MCM5(1), MCM6(1), MCM7(1), NACA(1), POLD3(1), POLE(3), RFC2(1), RFC3(1), RPA1(1), RPA2(1), UBB(1), UBC(1)	24931291	20	15	20	2	6	6	1	5	2	0	0.0575	0.869	1.000
260	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	TRAF2(1)	4089381	1	1	1	0	1	0	0	0	0	0	0.705	0.882	1.000
261	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	IL10RA(1), JAK1(2), STAT1(1), STAT3(3), STAT5A(1)	6003104	8	6	8	2	2	0	0	5	1	0	0.666	0.883	1.000
262	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	10	MYT1(1), RB1(2)	5168520	3	3	3	1	2	0	0	1	0	0	0.731	0.883	1.000
263	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CAMK1(1), CAMK2D(1), MEF2C(1), PPP3CA(1), PPP3CC(1), SYT1(1)	9908223	6	5	6	0	1	0	2	3	0	0	0.264	0.883	1.000
264	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH4(1), ADHFE1(1), AGPAT2(1), AGPAT3(1), AGPAT4(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), DGKD(3), DGKQ(1), DGKZ(1), GK(1), LCT(1), PNLIPRP1(2), PPAP2A(1)	23611503	20	18	20	3	2	5	4	5	4	0	0.223	0.885	1.000
265	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	FLT3(1), IL9(1)	4065467	2	2	2	3	0	0	0	1	1	0	0.991	0.889	1.000
266	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(1), IFNB1(1), IL12A(1), ITGAX(3)	9175859	6	6	6	2	1	1	1	0	3	0	0.718	0.893	1.000
267	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(1), BIRC2(1), SCAP(1), SREBF2(1)	8987006	4	4	4	1	0	2	0	2	0	0	0.651	0.893	1.000
268	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	23	FLT1(1), KDR(4), NOS3(2), PRKCA(1), SHC1(1), VHL(2)	15415143	11	11	11	2	4	4	1	1	1	0	0.386	0.896	1.000
269	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	ITGA4(1), ITGAL(2), ITGAM(1), ITGB2(1), SELE(2), SELP(2)	7823955	9	9	9	3	2	3	1	3	0	0	0.727	0.901	1.000
270	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLE(3), POLG(1), POLQ(1)	8236216	5	5	5	1	2	2	0	1	0	0	0.521	0.901	1.000
271	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	11	EGR1(1), KLK2(1)	3825685	2	2	2	2	0	1	0	0	1	0	0.968	0.901	1.000
272	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(2), ACE2(1), AGTR1(1), ANPEP(1), CMA1(1), CTSA(1), ENPEP(1), MAS1(1), MME(2)	10400699	11	11	11	3	3	5	1	2	0	0	0.558	0.903	1.000
273	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(1)	4700525	1	1	1	1	1	0	0	0	0	0	0.964	0.904	1.000
274	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	7	SHC1(1)	4109940	1	1	1	1	0	1	0	0	0	0	0.927	0.905	1.000
275	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(1), BAD(1), CASP1(1), CD40(1), DAXX(1), FAS(1), FASLG(1), LTA(1), MCL1(1), NFKB1(2), NTRK1(1), TFG(1), TRAF2(1)	21378285	14	13	14	1	5	4	0	2	3	0	0.114	0.906	1.000
276	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	THBS1(1)	3646982	1	1	1	1	0	0	0	1	0	0	0.943	0.906	1.000
277	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	CTSD(1), GREB1(1), MTA1(1), MTA3(1)	5309050	4	4	4	2	2	2	0	0	0	0	0.759	0.907	1.000
278	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(1), BIRC2(1), CFLAR(1), LMNA(1), NFKB1(2), RELA(2), SPTAN1(1), TNFRSF10A(1), TNFRSF10B(1), TRAF2(1)	16397083	12	12	12	2	5	5	0	1	1	0	0.289	0.907	1.000
279	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	17	ABL1(1), BRCA1(2), NFKB1(2), RELA(2)	11223787	7	6	7	1	3	1	0	3	0	0	0.382	0.907	1.000
280	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	GOT2(1)	4281056	1	1	1	0	0	1	0	0	0	0	0.725	0.911	1.000
281	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH4(1), ADHFE1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), ALDOC(2), ENO1(2), GCK(1), GPI(1), HK2(1), HK3(1), PFKM(2), PFKP(2), PGK1(1), PGM3(1), TPI1(1)	24039266	22	19	22	4	5	5	3	5	4	0	0.201	0.912	1.000
282	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH4(1), ADHFE1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), ALDOC(2), ENO1(2), GCK(1), GPI(1), HK2(1), HK3(1), PFKM(2), PFKP(2), PGK1(1), PGM3(1), TPI1(1)	24039266	22	19	22	4	5	5	3	5	4	0	0.201	0.912	1.000
283	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(2), POLR1B(1), POLR1C(1), POLR2B(1), POLR3A(2)	11540660	7	7	7	2	3	1	2	1	0	0	0.646	0.925	1.000
284	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	GBGT1(1), HEXB(2), NAGA(2), ST3GAL1(1)	4969106	6	6	6	4	2	3	0	0	1	0	0.916	0.928	1.000
285	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP2A13(2), CYP2A6(1)	3940625	3	3	3	2	0	2	0	1	0	0	0.861	0.928	1.000
286	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	19	BRCA1(2), BRCA2(4), FANCA(1), FANCC(1), FANCD2(1), FANCF(1), FANCG(1), TREX1(1)	18280527	12	10	12	1	4	2	1	2	3	0	0.257	0.930	1.000
287	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	24	CSNK2A1(1), EGF(2), EGFR(4), JAK1(2), MAP2K4(2), PRKCA(1), SHC1(1), STAT1(1), STAT3(3), STAT5A(1)	17110118	18	15	18	4	5	2	1	9	1	0	0.406	0.935	1.000
288	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	PRKCA(1)	4709002	1	1	1	1	0	0	0	1	0	0	0.971	0.937	1.000
289	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	MAP3K7(1), NFKB1(2), RELA(2), TNFAIP3(1)	11866380	6	6	6	1	2	1	0	1	2	0	0.552	0.937	1.000
290	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	20	CFL1(1), LIMK1(1), PLCB1(3), PRKCA(1), ROCK2(1)	12088662	7	6	7	0	2	3	0	1	1	0	0.183	0.937	1.000
291	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	18	APAF1(1), BIRC2(1)	6640164	2	2	2	0	0	2	0	0	0	0	0.569	0.938	1.000
292	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	GBGT1(1), HEXB(2), NAGA(2), ST3GAL1(1)	5275825	6	6	6	4	2	3	0	0	1	0	0.921	0.940	1.000
293	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(1), BIRC2(1), CASP1(1), LMNA(1)	9527513	4	4	4	1	0	3	0	0	1	0	0.729	0.940	1.000
294	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	CAPNS1(1)	4545485	1	1	1	1	0	0	0	1	0	0	0.948	0.942	1.000
295	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(1), HNF4A(1), NR1D2(2), NR1H3(1), NR1I3(2), NR2F1(1), NR5A2(1), PGR(2), PPARG(1)	20515668	12	12	12	1	2	2	1	4	3	0	0.179	0.942	1.000
296	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	20	ARHGAP5(2), ITGA1(1), MYLK(3), PFN1(1), ROCK1(4), SHC1(1), TLN1(2)	17135770	14	13	13	3	1	3	2	5	3	0	0.587	0.942	1.000
297	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	CAD(2), CANT1(1), CTPS2(1), DPYD(4), ENTPD3(1), ENTPD6(1), ENTPD8(1), NME1(1), NT5E(1), POLA1(1), POLD3(1), POLE(3), POLR1A(2), POLR1B(1), POLR1C(1), POLR2B(1), POLR3A(2), PRIM2(1), RRM1(3), RRM2B(1), TXNRD1(1), TYMS(1), UCK2(1), UMPS(1), UPP1(1)	39779483	35	27	35	5	12	4	3	11	5	0	0.0693	0.944	1.000
298	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	21	CRK(1), NFKB1(2), PRKCA(1), RELA(2)	12218236	6	6	6	0	2	1	0	3	0	0	0.197	0.945	1.000
299	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH4(1), ADHFE1(1), AGK(1), AGPAT2(1), AGPAT3(1), AGPAT4(1), ALDH1A3(1), ALDH1B1(1), DAK(1), DGAT2(1), DGKD(3), DGKI(4), DGKQ(1), DGKZ(1), GK(1), LCT(1), MGLL(1), PNLIPRP1(2), PPAP2A(1)	28783072	25	23	25	4	4	4	5	6	6	0	0.208	0.948	1.000
300	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	IFNB1(1), IL12A(1), IL7(1), LTA(1)	6542511	4	4	4	3	1	1	0	0	2	0	0.959	0.948	1.000
301	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	12	CCNE2(1)	4210157	1	1	1	1	0	0	0	1	0	0	0.950	0.949	1.000
302	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD8A(1), ITGAL(2), ITGB2(1), PTPRC(3)	5293080	7	7	7	6	1	3	0	2	1	0	0.975	0.950	1.000
303	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(1), ITGAL(2), ITGB2(1)	4295718	4	4	4	4	1	2	0	0	1	0	0.961	0.950	1.000
304	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(1), HEMK1(1), MARS(1), MARS2(1), METTL6(1), PAPSS2(1), PRMT3(2), PRMT5(2), SEPHS1(1), SEPHS2(2)	12265090	13	12	13	5	2	3	0	4	4	0	0.730	0.951	1.000
305	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	20	CSNK2A1(1), IL6ST(3), JAK1(2), JAK3(2), SHC1(1), STAT3(3)	11467520	12	10	12	4	3	1	1	3	4	0	0.797	0.951	1.000
306	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(4), PPP1CA(1)	5701401	5	5	5	3	0	0	0	4	1	0	0.923	0.951	1.000
307	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	7	MYT1(1)	3683046	1	1	1	1	1	0	0	0	0	0	0.927	0.952	1.000
308	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(1), ACTR3(1), ARPC4(1), NTRK1(1), RAC1(1), WASF1(1), WASF2(1), WASF3(1)	7529058	8	8	8	4	0	4	1	1	2	0	0.920	0.962	1.000
309	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	CDC34(1), UBE2D1(1), UBE2I(1), UBE2L3(1)	5183827	4	3	4	2	2	2	0	0	0	0	0.858	0.963	1.000
310	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG12(1), IFNA10(1), IFNA13(1), IFNA16(2), IFNA17(1), IFNA21(1), IFNA6(1), PRKAA2(2)	10395665	10	10	10	3	2	2	0	5	1	0	0.719	0.968	1.000
311	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ALDH1A3(1), AOC2(2), DDC(1), EPX(1), ESCO1(4), ESCO2(1), GOT2(1), MAOA(1), MPO(1), TPO(1)	16769574	14	13	14	4	4	4	1	1	4	0	0.595	0.972	1.000
312	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(2), ACSS2(1), ADH4(1), ADHFE1(1), ALDH1A3(1), ALDH1B1(1), ALDOC(2), ENO1(2), G6PC2(1), GCK(1), GPI(1), HK2(1), HK3(1), PFKL(2), PFKM(2), PFKP(2), PGK1(1), PGK2(1), PGM3(1), TPI1(1)	28619988	26	24	26	5	7	4	2	7	6	0	0.179	0.974	1.000
313	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	ARSD(1), ARSE(1), CYP11B2(1), CYP19A1(1), HEMK1(1), HSD11B1(1), HSD3B1(1), HSD3B2(1), METTL6(1), PRMT3(2), PRMT5(2), STS(1), SULT1E1(1), UGT1A1(2), UGT1A3(1), UGT1A7(1), UGT2A3(1), UGT2B11(2), UGT2B15(3), UGT2B28(1), UGT2B7(1)	24694487	27	22	27	7	5	2	2	9	9	0	0.451	0.975	1.000
314	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	PRKCA(1), SYT1(1)	6771094	2	2	2	1	1	0	0	1	0	0	0.840	0.976	1.000
315	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	36	CAMK1(1), NCF2(1), NFATC2(1), NFATC4(1), NFKB1(2), PLCB1(3), PPP3CA(1), PPP3CC(1), RAC1(1), RELA(2), SYT1(1)	18518880	15	12	15	3	7	3	1	4	0	0	0.286	0.977	1.000
316	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(1), ATP6V0D1(1), ATP6V1A(2), ATP6V1B2(1), ATP6V1C2(3)	7408602	8	7	8	3	4	0	2	1	1	0	0.725	0.977	1.000
317	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(1), ATP6V0D1(1), ATP6V1A(2), ATP6V1B2(1), ATP6V1C2(3)	7408602	8	7	8	3	4	0	2	1	1	0	0.725	0.977	1.000
318	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(1), ATP6V0D1(1), ATP6V1A(2), ATP6V1B2(1), ATP6V1C2(3)	7408602	8	7	8	3	4	0	2	1	1	0	0.725	0.977	1.000
319	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	MRPL13(1), RPL10A(2), RPL11(2), RPL28(1), RPL7(1), RPS10(1)	11230363	8	8	8	3	1	2	0	4	1	0	0.759	0.981	1.000
320	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	13	ACTR3(1), ARPC4(1), RAC1(1)	5532316	3	3	3	2	0	1	0	1	1	0	0.912	0.981	1.000
321	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	12	CTNNA1(1), CTNNA2(1)	8600184	2	2	2	0	0	1	0	1	0	0	0.589	0.981	1.000
322	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ABL1(1), ACTG1(2), ARHGEF2(2), ARPC5L(1), CD14(1), CDH1(2), EZR(1), KRT18(1), LY96(1), PRKCA(1), ROCK1(4), ROCK2(1), TLR5(1), TUBA1C(1), TUBA3C(3), TUBB1(1), TUBB2B(1), TUBB8(1), WAS(1)	25037468	27	27	26	6	4	8	3	9	3	0	0.389	0.981	1.000
323	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ABL1(1), ACTG1(2), ARHGEF2(2), ARPC5L(1), CD14(1), CDH1(2), EZR(1), KRT18(1), LY96(1), PRKCA(1), ROCK1(4), ROCK2(1), TLR5(1), TUBA1C(1), TUBA3C(3), TUBB1(1), TUBB2B(1), TUBB8(1), WAS(1)	25037468	27	27	26	6	4	8	3	9	3	0	0.389	0.981	1.000
324	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(1), CAPNS1(1), ITGA1(1), RAC1(1), SPTAN1(1), TLN1(2)	14039613	7	7	7	2	1	0	2	3	1	0	0.665	0.983	1.000
325	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AGXT(1), ASPA(1), CAD(2), DDO(1), GAD1(1), GAD2(3), GOT2(1), GPT(1), PC(1)	12826108	12	12	12	4	2	3	2	2	3	0	0.779	0.983	1.000
326	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	GFPT2(1), GNPNAT1(1), HEXB(2), HK2(1), HK3(1), MTMR2(1), MTMR6(1), NAGK(1), PGM3(1)	14095011	10	10	10	3	1	3	1	3	2	0	0.758	0.984	1.000
327	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	18	CSNK2A1(1), IGF1R(2), IRS1(2), SHC1(1)	10864178	6	5	6	2	1	1	0	3	1	0	0.750	0.984	1.000
328	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	DAB1(2), LRP8(1), RELN(2), VLDLR(1)	6915912	6	6	6	3	1	1	0	3	1	0	0.903	0.984	1.000
329	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB11(2)	7052447	2	2	2	3	1	0	0	0	1	0	0.990	0.985	1.000
330	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	40	APAF1(1), BIRC2(1), FAS(1), FASLG(1), MAP2K4(2), MAPK10(1), MCL1(1), NFKB1(2), PARP1(2), RELA(2), TRAF2(1)	17947564	15	15	15	4	4	7	0	3	1	0	0.467	0.987	1.000
331	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(2), LDLR(1), MBTPS1(1), SCAP(1), SREBF2(1)	5854042	6	6	6	3	0	1	0	4	1	0	0.888	0.987	1.000
332	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH4(1), ADHFE1(1), ALDH1A3(1), ALDH1B1(1)	6525777	4	4	4	2	1	1	0	2	0	0	0.842	0.987	1.000
333	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	23	ACTA1(1), CAPNS1(1), EGF(2), EGFR(4), ITGA1(1), MYLK(3), TLN1(2)	15812024	14	14	14	4	3	1	3	6	1	0	0.640	0.987	1.000
334	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(1), C6(4), C9(2)	6203052	7	7	7	4	2	4	0	0	1	0	0.910	0.987	1.000
335	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	CFLAR(1), DAXX(1), FAF1(1), LMNA(1), MAP2K4(2), MAP3K7(1), PAK2(1), PRKDC(3), RB1(2), RIPK2(2), SPTAN1(1)	20009069	16	14	16	3	3	3	1	6	3	0	0.439	0.988	1.000
336	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	CAD(2), CANT1(1), CTPS2(1), DPYD(4), NME1(1), NT5E(1), POLE(3), POLG(1), POLQ(1), POLR1B(1), POLR2B(1), RRM1(3), TXNRD1(1), TYMS(1), UCK2(1), UMPS(1), UPP1(1)	28166208	25	21	25	5	7	4	1	10	3	0	0.279	0.988	1.000
337	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	PGAP1(1), PIGA(1), PIGO(1), PIGT(1)	11710680	4	4	4	0	1	2	0	1	0	0	0.290	0.988	1.000
338	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	B3GNT2(1), B3GNT3(1), B3GNT4(1), B4GALT2(1), B4GALT4(1), ST3GAL6(1)	7954625	6	6	6	3	2	1	1	1	0	1	0.901	0.989	1.000
339	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(3), ACAA2(1), ACADSB(1), ACAT1(1), ACOX1(1), ACOX3(1), ADH4(1), ADHFE1(1), ALDH1A3(1), ALDH1B1(1), CPT1B(1), CPT1C(1), EHHADH(5), HSD17B4(1)	24128097	20	16	20	4	5	3	1	6	5	0	0.321	0.989	1.000
340	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	11	APC(2)	9747737	2	2	2	2	0	0	0	0	2	0	0.983	0.989	1.000
341	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT2(1), AGPAT3(1), AGPAT4(1), ENPP2(2), PLA2G2A(1), PLA2G4A(1), PLD1(2), PPAP2A(1)	11406026	10	9	10	4	1	3	2	1	3	0	0.807	0.989	1.000
342	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(3), ACAA2(1), ACADSB(1), ACAT1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), AOX1(2), BCKDHA(1), EHHADH(5), HMGCL(2), IVD(1)	17740250	22	17	22	8	4	4	3	4	7	0	0.804	0.990	1.000
343	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), AOC2(2), ASPA(1), CNDP1(1), DDC(1), HAL(1), HARS(1), HDC(1), MAOA(1)	11968004	14	11	14	6	5	4	1	1	3	0	0.820	0.990	1.000
344	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	15	B3GAT3(1), CHPF(1), CHST12(1), CHSY1(1), XYLT1(2)	6711824	6	6	6	3	2	1	1	1	1	0	0.833	0.990	1.000
345	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	IL12A(1), IL12RB2(1), STAT4(3), TYK2(1)	9132156	6	6	6	4	1	0	1	2	2	0	0.954	0.990	1.000
346	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	HMGCS1(2), LSS(1)	6438484	3	3	3	4	1	0	0	1	1	0	0.992	0.990	1.000
347	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACAA1(3), ACOX1(1), ACOX3(1), CPT1B(1), CPT1C(1), CYP7A1(1), CYP8B1(1), EHHADH(5), FABP1(1), FABP2(1), FABP3(1), FABP4(1), FADS2(1), GK(1), MMP1(2), NR1H3(1), PCK2(1), PPARG(1), SLC27A4(1), SLC27A5(1), SLC27A6(1), SORBS1(2), UBC(1)	32178790	31	25	30	6	9	4	1	11	6	0	0.237	0.990	1.000
348	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(3), EBP(1), GGCX(1), LSS(1), TM7SF2(1)	9409730	7	7	7	3	1	3	0	1	2	0	0.857	0.990	1.000
349	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	LMNA(1), MADD(3), MAP2K4(2), MAP3K7(1), PAK2(1), PRKDC(3), RB1(2), SPTAN1(1), TRAF2(1)	19002383	15	12	15	3	6	2	1	3	3	0	0.414	0.991	1.000
350	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	IL12A(1), IL12RB2(1), IL4R(3)	6252386	5	4	5	2	1	0	1	1	2	0	0.816	0.991	1.000
351	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	49	ACOX1(1), CITED2(1), CPT1B(1), CREBBP(2), DUSP1(1), EHHADH(5), FABP1(1), HSD17B4(1), HSPA1A(1), NCOA1(2), NCOR1(6), NR1H3(1), NR2F1(1), NRIP1(2), PRKCA(1), PTGS2(2), RB1(2), RELA(2), SP1(2), STAT5A(1), STAT5B(1)	30025424	37	30	37	8	11	10	0	8	8	0	0.268	0.991	1.000
352	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	LTA(1), MAP2K4(2), NFKB1(2), RELA(2), TANK(1), TRAF2(1)	11782062	9	8	9	3	4	2	0	3	0	0	0.646	0.991	1.000
353	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(1), B4GALNT1(1), HEXB(2), LCT(1), ST3GAL1(1), ST6GALNAC4(1), ST6GALNAC5(1), ST8SIA5(1)	8127989	9	7	9	6	3	4	0	1	1	0	0.926	0.991	1.000
354	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	24	ADCY1(1), AKT1(3), CAMK2D(1), PRKCA(1), RAC1(1), RPS6KA5(2)	13034410	9	9	8	3	1	2	2	4	0	0	0.788	0.991	1.000
355	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	CARS(1), EPRS(1), GARS(1), HARS(1), LARS(1), LARS2(1), MARS(1), MARS2(1), QARS(2)	15815368	10	9	10	2	5	2	0	2	1	0	0.450	0.991	1.000
356	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6V0A1(1), ATP6V0D1(1), ATP6V1A(2), ATP6V1B2(1), ATP6V1C2(3)	7874541	8	7	8	4	4	0	2	1	1	0	0.857	0.992	1.000
357	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(1), EPHA4(1), EPHB1(2), ITGA1(1), L1CAM(2), LYN(1), SELP(2)	7758058	10	9	10	6	3	1	2	3	1	0	0.943	0.992	1.000
358	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	BTG1(1), CRY1(1), DAZAP2(1), ETV6(1), GSTM3(1), HERPUD1(1), HSPA8(5), NCOA4(2), NR1D2(2), PER1(2), PER2(1), SF3A3(1), VAPA(2), ZFR(1)	17988363	22	20	22	6	5	3	2	7	5	0	0.654	0.992	1.000
359	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	NFATC2(1)	5959965	1	1	1	1	1	0	0	0	0	0	0.944	0.992	1.000
360	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(2), GRM1(4), GRM2(1), GRM5(1), GRM8(1)	10345592	9	9	9	4	4	2	1	0	2	0	0.760	0.993	1.000
361	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(2), CDH1(2), CREBBP(2), MAP3K7(1), TGFBR1(1)	12666520	8	7	8	4	1	0	1	3	3	0	0.941	0.993	1.000
362	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(2), ANAPC2(1), ANAPC4(1), ANAPC5(1), ANAPC7(1), CDC16(1), CDC20(2), CDC27(1), CUL2(3), CUL3(1), FBXW11(2), FZR1(1), SMURF2(1), TCEB2(1), UBE2D1(1), VHL(2), WWP1(1)	19750993	23	23	23	5	2	5	2	8	6	0	0.547	0.993	1.000
363	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(1), ACPT(1), ALPP(2), CYP19A1(1), CYP1A1(1), CYP2A13(2), CYP2A6(1), CYP2B6(2), CYP2C19(2), CYP2C8(2), CYP2J2(1), PON1(1)	14432115	17	16	17	7	0	6	1	7	3	0	0.795	0.994	1.000
364	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	DLG4(1), GRIN1(1), GRIN2A(6), GRIN2B(5), NOS1(1), PPP3CA(1), PPP3CC(1), PRKCA(1), SYT1(1)	12547055	18	18	18	5	3	6	4	4	1	0	0.506	0.995	1.000
365	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	28	BAD(1), DUSP4(1), DUSP9(1), EIF4E(1), NFKB1(2), RPS6KA3(1), SHC1(1)	13780565	8	6	8	2	5	1	0	1	1	0	0.492	0.995	1.000
366	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	16	CSNK2A1(1), KLK2(1), SHC1(1)	8060408	3	3	3	2	1	1	0	0	1	0	0.927	0.995	1.000
367	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	22	ABL1(1), DHFR(1), RB1(2), TFDP1(1)	11225518	5	5	5	2	1	0	0	3	1	0	0.869	0.995	1.000
368	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ALDH18A1(1), ARG2(1), CKB(1), CKMT1B(1), CKMT2(1), CPS1(2), PYCR1(1)	8586618	8	7	8	4	3	2	1	1	1	0	0.834	0.995	1.000
369	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	13	APC(2), CREBBP(2), LEF1(1), TRRAP(3)	15565488	8	8	8	7	1	1	0	2	4	0	0.989	0.995	1.000
370	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ALDH1A3(1), AOC2(2), DDC(1), EPX(1), GOT2(1), MAOA(1), MPO(1), TPO(1)	10728999	9	8	9	4	2	3	1	1	2	0	0.806	0.996	1.000
371	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	21	APC(2), CREBBP(2), CSNK2A1(1), MAP3K7(1), WIF1(2)	13677420	8	8	8	5	3	0	0	2	3	0	0.966	0.996	1.000
372	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	19	B2M(1), RAC1(1), SYK(2)	8075675	4	4	4	4	0	2	0	1	1	0	0.984	0.996	1.000
373	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(1), CASP1(1), INSR(1), MAGI1(1), MAGI2(1), WWP1(1)	11817584	6	5	6	2	2	2	0	2	0	0	0.728	0.996	1.000
374	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	23	GH1(1), GHR(2), INSR(1), IRS1(2), PRKCA(1), SHC1(1), STAT5A(1), STAT5B(1)	14997187	10	9	10	3	4	2	1	2	1	0	0.651	0.997	1.000
375	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ADH4(1), ADHFE1(1), ALDH1A3(1), AOC2(2), AOX1(2), DBH(2), DDC(1), ESCO1(4), ESCO2(1), GOT2(1), HEMK1(1), MAOA(1), METTL6(1), PRMT3(2), PRMT5(2), TPO(1), TYRP1(2)	29207291	26	24	26	9	5	6	0	6	9	0	0.745	0.997	1.000
376	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(2), NFKB1(2), RELA(2), TRAF2(1)	9519873	7	7	7	3	3	1	1	2	0	0	0.803	0.997	1.000
377	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AADAC(1), ACAT1(1), ACSM1(1), ALDH1A3(1), ALDH1B1(1), DDHD1(2), EHHADH(5), GAD1(1), GAD2(3), HMGCL(2), HMGCS1(2), HSD17B4(1)	19937207	21	19	21	6	4	3	3	5	6	0	0.619	0.997	1.000
378	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	21	INPPL1(1), ITPKB(1), OCRL(1), PIK3C2A(1), PIK3CB(2), PIK3CG(1), PLCB1(3), PLCG2(1)	19672941	11	9	11	3	3	4	0	3	1	0	0.501	0.997	1.000
379	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ACACA(1), ACADSB(1), ACAT1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), EHHADH(5), SUCLG1(1)	16317449	14	12	14	6	3	3	2	2	4	0	0.899	0.997	1.000
380	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1S(2), C3(1), C6(4), C9(2)	8608283	9	9	9	5	2	4	0	2	1	0	0.911	0.998	1.000
381	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	21	CFL1(1), CHN1(1), LIMK1(1), MYLK(3), NCF2(1), PLD1(2), RAC1(1), TRIO(4), WASF1(1)	16097630	15	14	15	5	4	3	1	4	3	0	0.746	0.998	1.000
382	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG5(1), B4GALT2(1), DPAGT1(1), FUT8(1), MGAT5(1), ST6GAL1(2)	9768514	7	7	7	3	4	1	1	1	0	0	0.729	0.999	1.000
383	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	26	AKT1(3), BAD(1), IL4R(3), IRS1(2), JAK1(2), JAK3(2), PDK1(1), PIK3CD(2), SHC1(1)	16899197	17	15	16	5	2	4	4	3	4	0	0.646	0.999	1.000
384	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(1), AASDH(1), AASDHPPT(1), AASS(1), ACAT1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), BBOX1(1), DOT1L(2), EHHADH(5), EHMT2(1), PLOD1(1), PLOD3(1), SHMT2(1)	18191172	22	19	22	7	6	4	3	5	4	0	0.612	0.999	1.000
385	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	CP(3), EPRS(1), HMBS(1), UGT1A1(2), UGT1A3(1), UGT1A7(1), UGT2B15(3)	13511500	12	11	12	7	4	2	1	3	2	0	0.925	0.999	1.000
386	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	CAD(2), CPS1(2), EPRS(1), GAD1(1), GAD2(3), GLUL(1), GOT2(1), GPT(1), QARS(2)	16356644	14	13	14	5	3	4	1	3	3	0	0.743	0.999	1.000
387	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	CAD(2), CPS1(2), EPRS(1), GAD1(1), GAD2(3), GFPT2(1), GLUD2(1), GLUL(1), GNPNAT1(1), GOT2(1), GPT(1), NAGK(1), QARS(2)	19452125	18	17	18	7	3	6	1	4	4	0	0.817	0.999	1.000
388	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ADH4(1), ADHFE1(1), ALDH1A3(1), AOC2(2), AOX1(2), DBH(2), DDC(1), GOT2(1), MAOA(1), TPO(1)	15539269	13	12	13	5	2	4	0	4	3	0	0.790	0.999	1.000
389	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	CD97(1), ELTD1(1), EMR2(3), GHRHR(1), GIPR(1), GLP1R(1), GLP2R(3), GPR64(1), LPHN1(1), LPHN2(1), LPHN3(4), VIPR1(1)	13069231	19	19	19	7	3	1	1	12	2	0	0.795	0.999	1.000
390	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	24	CSNK2A1(1), JAK1(2), MAP2K4(2), PRKCA(1), SHC1(1), STAT1(1), STAT3(3), STAT5A(1)	15847386	12	9	12	4	3	2	0	6	1	0	0.678	0.999	1.000
391	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(1), COL4A2(2), COL4A4(2), SLC23A2(1)	12186134	6	6	6	2	1	3	0	0	2	0	0.853	0.999	1.000
392	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	29	AKT1(3), CAMK1(1), IGF1R(2), INSR(1), MEF2C(1), NFATC2(1), PPP3CA(1), PPP3CC(1), SYT1(1)	15982507	12	10	11	4	3	2	2	5	0	0	0.692	0.999	1.000
393	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ALDH18A1(1), ALDH1A3(1), ALDH1B1(1), AMD1(1), AOC2(2), ARG2(1), CPS1(2), MAOA(1), SAT2(1)	14419327	11	10	11	7	5	2	0	2	2	0	0.951	0.999	1.000
394	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(2), DAG1(2), ITPKB(1), MAP2K4(2), MAPK10(1), MAPK9(1)	14056046	9	8	9	4	2	3	1	1	2	0	0.834	0.999	1.000
395	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AGXT(1), ASPA(1), CAD(2), DDO(1), GAD1(1), GAD2(3), GOT2(1), GPT(1), PC(1)	18608959	12	12	12	4	2	3	2	2	3	0	0.781	0.999	1.000
396	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	47	AKT1(3), BRD4(1), INPPL1(1), IRS1(2), PDK1(1), PIK3CD(2), RPS6KA3(1), SHC1(1), SORBS1(2)	27833822	14	13	13	3	1	5	3	2	3	0	0.448	0.999	1.000
397	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1S(2), C3(1), C6(4), C9(2), MASP1(1)	10232615	10	10	10	5	2	4	0	3	1	0	0.884	0.999	1.000
398	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	19	CSNK2A1(1), INSR(1), IRS1(2), SHC1(1)	11189700	5	5	5	3	2	1	0	1	1	0	0.921	0.999	1.000
399	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	IFNB1(1), IRAK2(1), MAP3K7(1), NFKB1(2), RELA(2)	14517576	7	7	7	5	2	2	0	1	2	0	0.981	0.999	1.000
400	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	80	ACVR1B(1), ACVRL1(1), AKT1(3), AURKB(1), BMPR1A(1), BMPR2(1), BUB1(1), CDKL2(1), CDS1(1), CLK1(1), CLK2(1), COL4A3BP(1), CSNK2A1(1), CSNK2A2(1), DGKD(3), DGKQ(1), DGKZ(1), INPPL1(1), ITPKB(1), NEK1(1), OCRL(1), PIK3C2A(1), PIK3CB(2), PIK3CG(1), PLCB1(3), PLCG2(1), PLK3(3), PRKACA(1), PRKCA(1), PRKCG(1), PRKD1(1), RPS6KA3(1), TGFBR1(1)	53074379	42	38	41	7	6	13	5	14	4	0	0.105	0.999	1.000
401	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR1(1), ATP8A1(1), AVPR1A(3), AVPR1B(1), BRS3(1), CCKAR(1), CCKBR(1), CCR1(1), CCR2(3), CCR4(1), LHCGR(1), MC4R(1), NPY1R(1), NPY2R(2), OPRL1(1), OXTR(1), SSTR1(2), TACR1(1), TACR3(3), TSHR(1)	25728469	28	24	28	8	7	9	3	5	4	0	0.351	1.000	1.000
402	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	ACTG1(2), APAF1(1), BIRC2(1), CFLAR(1), DAXX(1), LMNA(1), NFKB1(2), NUMA1(1), PAK2(1), PRKDC(3), RB1(2), RELA(2), SPTAN1(1), TRAF2(1)	33955858	20	17	20	4	6	6	1	5	2	0	0.350	1.000	1.000
403	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1S(2), C3(1), C6(4), C9(2), MASP1(1), MASP2(1)	10479506	11	11	11	5	2	4	0	4	1	0	0.853	1.000	1.000
404	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	58	BTK(1), CAD(2), DAXX(1), EGFR(4), FAF1(1), MAP2K4(2), MAPK10(1), MAPK9(1), MET(3), NFKB1(2), NFKBIB(1), PFN1(1), PFN2(2), ROCK1(4), TNFRSF6B(1), TPX2(1), TRAF2(1)	35345790	29	25	28	6	10	3	2	10	4	0	0.271	1.000	1.000
405	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	31	APC(2), ATF2(2), BMP4(1), BMPR1A(1), BMPR2(1), MAP3K7(1), MEF2C(1), NPPB(1), TGFBR1(1), TGFBR3(1)	17124043	12	11	12	7	1	3	1	4	3	0	0.965	1.000	1.000
406	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(1), COL4A2(2), COL4A4(2), F11(3), F2(1), F2R(1), F5(4), F8(3), FGA(4), FGB(1), PROC(1), PROS1(2)	21744198	25	25	25	7	7	6	3	4	5	0	0.774	1.000	1.000
407	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	21	CSNK2A1(1), JAK1(2), JAK3(2), SHC1(1), STAT5A(1), STAT5B(1), SYK(2)	11150903	10	9	10	5	3	4	1	1	1	0	0.842	1.000	1.000
408	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	AGXT(1), ALAS1(1), ALAS2(1), AOC2(2), CPT1B(1), DAO(1), GARS(1), GLDC(2), MAOA(1), PLCG2(1), SARDH(1), SHMT2(1)	20530391	14	13	14	5	4	0	3	3	4	0	0.801	1.000	1.000
409	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	25	AKT1(3), IL13RA1(1), IL4R(3), INPP5D(1), JAK1(2), JAK3(2), SHC1(1), TYK2(1)	17063350	14	13	13	6	1	4	3	3	3	0	0.863	1.000	1.000
410	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	AGXT(1), ALAS1(1), ALAS2(1), AOC2(2), DAO(1), GARS(1), GLDC(2), MAOA(1), SARDH(1), SHMT2(1), TARS2(1)	20889781	13	12	13	6	5	0	3	1	4	0	0.908	1.000	1.000
411	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSB(2), ARSD(1), ARSE(1), GAL3ST1(1), LCT(1), NEU4(1), PPAP2A(1), SMPD2(2), SPTLC2(1)	11856491	11	11	11	5	2	2	1	5	1	0	0.836	1.000	1.000
412	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	56	BMP4(1), BMP6(1), CSNK1G1(1), CSNK1G3(1), DHH(1), FBXW11(2), GLI1(3), GLI2(2), GLI3(2), HHIP(3), LRP2(2), PRKACA(1), PTCH2(3), SHH(1), STK36(1), WNT2(1), WNT6(1), WNT9A(1)	29940508	28	27	28	7	2	13	1	9	3	0	0.334	1.000	1.000
413	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(3), ACAA2(1), ADH4(1), ADHFE1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), CYP7A1(1)	11430989	12	10	12	5	2	3	1	5	1	0	0.789	1.000	1.000
414	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	AKT1(3), APC(2), CAV3(1), DAG1(2), DLG4(1), ITPR1(1), ITPR2(5), RAC1(1), RYR1(2)	22526372	18	18	17	7	2	5	3	4	4	0	0.827	1.000	1.000
415	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	31	ACTR3(1), AKT1(3), DAG1(2), ETFA(1), ITGA9(2), ITPKB(1), ITPR1(1), ITPR2(5), NR1I3(2), PDE3B(1), PIK3CD(2)	22840366	21	21	20	6	1	11	2	3	4	0	0.602	1.000	1.000
416	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	GALNT10(1), GALNT11(1), GALNT13(1), GALNT14(1), GALNT3(1), GALNT4(1), GALNT8(1), GALNTL5(1), OGT(1), ST3GAL1(1), ST6GALNAC1(1), WBSCR17(1)	15889504	12	11	12	5	1	6	0	3	2	0	0.820	1.000	1.000
417	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG12(1), ALG14(1), ALG5(1), B4GALT2(1), DPAGT1(1), FUT8(1), GANAB(1), MAN1A2(1), MAN2A1(3), MGAT5(1), MGAT5B(1), ST6GAL1(2)	20713763	15	14	15	7	5	1	1	4	4	0	0.913	1.000	1.000
418	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	15	CREBBP(2), IL7(1), IL7R(1), JAK1(2), JAK3(2), STAT5A(1), STAT5B(1)	12628193	10	9	10	4	4	2	1	2	1	0	0.785	1.000	1.000
419	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	32	AKT1(3), BAD(1), CFLAR(1), IRS1(2), JAK1(2), JAK3(2), SHC1(1), STAT5A(1), STAT5B(1), SYK(2)	16441221	16	14	15	5	3	7	2	2	2	0	0.613	1.000	1.000
420	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(1), AASDHPPT(1), AASS(1), ACAT1(1), ALDH1A3(1), ALDH1B1(1), BBOX1(1), DOT1L(2), EHHADH(5), EHMT2(1), HSD17B4(1), NSD1(1), PLOD1(1), PLOD3(1), SETD1A(1), SETDB1(1), SHMT2(1)	28467156	22	19	22	9	6	4	2	4	6	0	0.832	1.000	1.000
421	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	64	APAF1(1), BAD(1), BCL2L11(1), BIRC2(1), BIRC5(1), CASP1(1), FAS(1), FASLG(1), IRF6(1), LTA(1), MAP2K4(2), MAPK10(1), NFKB1(2), NFKBIB(1), RELA(2), TNFRSF10B(1), TNFRSF21(1), TRAF2(1)	27360148	21	20	21	5	6	7	1	5	2	0	0.362	1.000	1.000
422	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	32	AKT1(3), DAG1(2), DRD2(1), EGFR(4), ITPKB(1), ITPR1(1), ITPR2(5), PIK3CB(2), PLCB1(3), SHC1(1), STAT3(3)	26818398	26	25	25	7	5	10	3	6	2	0	0.478	1.000	1.000
423	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ACACA(1), ACACB(1), ACAT1(1), ACSS1(2), ACSS2(1), ALDH1A3(1), ALDH1B1(1), EHHADH(5), SUCLG1(1)	19532573	14	12	14	7	5	2	1	3	3	0	0.933	1.000	1.000
424	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	16	CSF1R(2), RBL1(1), RBL2(2), SIN3B(2)	12349747	7	5	7	6	2	1	0	3	1	0	0.968	1.000	1.000
425	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1B(1), ADRA1D(2), ADRA2C(1), ADRB2(1), CHRM1(1), CHRM2(2), CHRM3(1), DRD2(1), DRD3(1), HTR1D(1), HTR5A(1), HTR6(1), HTR7(1)	12597329	15	14	15	7	4	7	1	2	1	0	0.769	1.000	1.000
426	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	70	ACACB(1), AKT1(3), CPT1B(1), CPT1C(1), G6PC2(1), IRS1(2), JAK1(2), JAK3(2), LEPR(1), MAPK10(1), MAPK9(1), NFKB1(2), NFKBIB(1), PCK2(1), PRKAA2(2), PRKAG1(2), PRKAG2(1), RELA(2), STAT3(3), TRAF2(1), TYK2(1)	40758096	32	27	31	7	8	5	3	13	3	0	0.335	1.000	1.000
427	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(1), DLG4(1), F2(1), PLD1(2)	13478352	5	5	5	8	3	0	1	0	1	0	0.999	1.000	1.000
428	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	38	ATF2(2), DAXX(1), MAP2K4(2), MAP3K7(1), MAP3K9(1), MAPKAPK5(1), MEF2C(1), PLA2G4A(1), RAC1(1), RPS6KA5(2), SHC1(1), STAT1(1), TGFBR1(1), TRAF2(1)	17725534	17	17	17	8	1	4	1	9	2	0	0.917	1.000	1.000
429	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	AGPAT2(1), AGPAT3(1), AGPAT4(1), CDS1(1), CHAT(2), CPT1B(1), DGKD(3), DGKQ(1), DGKZ(1), GNPAT(1), GPD1(1), PLA2G2A(1), PLA2G4A(1), PLCG2(1), PPAP2A(1)	24422789	18	17	18	5	0	5	2	6	5	0	0.605	1.000	1.000
430	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CREBBP(2), DUSP1(1), MAP3K7(1), NFKB1(2), RELA(2), TGFBR1(1)	14585889	9	8	9	6	3	2	0	3	1	0	0.968	1.000	1.000
431	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(2), ADCY3(1), ARF4(1), ARF5(1), ATP6V0A1(1), ATP6V0A2(3), ATP6V0D1(1), ATP6V1A(2), ATP6V1C2(3), PLCG2(1), PRKCA(1), SEC61A1(1), SEC61A2(1)	18175362	19	17	19	8	5	3	2	7	2	0	0.802	1.000	1.000
432	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(2), AMY2B(1), ENPP1(2), ENPP3(1), GAA(1), GANAB(1), GBE1(1), GCK(1), GPI(1), GYS1(1), HK2(1), HK3(1), MGAM(2), PGM3(1), PYGL(1), SI(2), UGT1A1(2), UGT1A3(1), UGT1A7(1), UGT2B15(3)	28039418	27	20	27	7	9	4	2	7	5	0	0.469	1.000	1.000
433	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	29	AKT1(3), APC(2), DACT1(2), DKK1(2), LRP1(1), PTPRA(1), WIF1(2)	19003087	13	12	12	6	1	5	1	4	2	0	0.894	1.000	1.000
434	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	42	AKT1(3), DDIT4(1), FIGF(1), PIK3CB(2), PIK3CD(2), PIK3CG(1), PIK3R2(1), PIK3R3(1), PRKAA2(2), RPS6KA3(1), RPS6KA6(1), RPS6KB2(1), TSC2(1)	24259528	18	18	17	5	0	7	1	6	4	0	0.582	1.000	1.000
435	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	250	ACVR1B(1), ACVR2A(1), BMPR1A(1), BMPR1B(1), BMPR2(1), CCL15(1), CCL28(1), CCL7(1), CCR1(1), CCR2(3), CCR4(1), CD40(1), CSF1R(2), CSF2RA(1), EGF(2), EGFR(4), FAS(1), FASLG(1), FLT1(1), FLT3(1), GH1(1), GH2(1), GHR(2), HGF(3), IFNA10(1), IFNA13(1), IFNA16(2), IFNA17(1), IFNA21(1), IFNA6(1), IFNB1(1), IL10RA(1), IL12A(1), IL12RB2(1), IL13RA1(1), IL17RA(1), IL17RB(1), IL20(1), IL21(1), IL22(1), IL23A(1), IL3RA(1), IL4R(3), IL5RA(1), IL6ST(3), IL7(1), IL7R(1), IL9(1), INHBA(2), INHBE(1), KDR(4), LEPR(1), LIF(1), LIFR(3), LTA(1), LTBR(2), MET(3), PRLR(2), TGFBR1(1), TNFRSF10A(1), TNFRSF10B(1), TNFRSF11B(1), TNFRSF13B(2), TNFRSF18(1), TNFRSF19(1), TNFRSF21(1), TNFRSF4(1), TNFRSF6B(1), TNFRSF8(1), TNFSF14(1), TNFSF15(1), TPO(1), XCL1(1), XCR1(1)	86988637	100	75	100	19	29	21	7	28	15	0	0.0403	1.000	1.000
436	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	ANKHD1(1), EEF2(1), EIF2AK3(4), EIF4E(1), EIF4G1(3), EIF5B(1)	21547485	11	11	11	8	1	2	1	5	2	0	0.988	1.000	1.000
437	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAS1(1), ALAS2(1), COX10(1), CP(3), EPRS(1), HMBS(1), UGT1A1(2), UGT1A3(1), UGT1A7(1), UGT2A3(1), UGT2B11(2), UGT2B15(3), UGT2B28(1), UGT2B7(1)	20745874	20	17	20	9	6	2	5	5	2	0	0.889	1.000	1.000
438	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(1), POLD3(1), POLE(3), POLG(1), POLG2(1), POLQ(1), PRIM2(1)	19947864	9	8	9	4	2	2	1	2	2	0	0.864	1.000	1.000
439	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2A1(1), GTF2B(1), GTF2E2(1), GTF2H3(1), GTF2I(1), TAF1(1), TAF13(1), TAF1L(5), TAF2(1), TAF4(1), TAF5(1), TAF5L(1), TAF6(2)	17734997	18	14	18	7	8	3	0	6	1	0	0.784	1.000	1.000
440	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	41	DAXX(1), EGF(2), EGFR(4), MAP2K4(2), NFKB1(2), PRKCA(1), PRKCG(1), RELA(2), SP1(2), TRAF2(1)	23908610	18	18	18	5	5	4	1	7	1	0	0.524	1.000	1.000
441	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(3), DUSP1(1), EIF4E(1), MAP2K4(2), MAP3K4(1), MAP3K7(1), MAPKAPK5(1), NFKB1(2)	16328832	12	12	11	5	2	5	1	3	1	0	0.832	1.000	1.000
442	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	44	INPP5B(2), INPP5E(2), INPPL1(1), IPMK(1), ITPKB(1), OCRL(1), PI4KA(1), PI4KB(1), PIK3CB(2), PIK3CD(2), PIK3CG(1), PIP4K2B(1), PIP5K1A(1), PLCB1(3), PLCE1(1), PLCG2(1), PLCZ1(1), SYNJ1(1), SYNJ2(2)	33853395	26	22	26	6	5	7	2	9	3	0	0.310	1.000	1.000
443	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	40	AKT1(3), CREBBP(2), DAG1(2), EGR1(1), FRS2(1), MAP2K4(2), MAPK10(1), MAPK9(1), NTRK1(1), PIK3CD(2), RPS6KA3(1), SHC1(1)	23304305	18	16	17	6	3	8	2	2	3	0	0.613	1.000	1.000
444	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(3), ACAA2(1), ADH4(1), ADHFE1(1), ALDH1A3(1), ALDH1B1(1), CYP7A1(1), SLC27A5(1)	15531660	10	9	10	5	2	1	0	6	1	0	0.868	1.000	1.000
445	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ARG2(1), CKB(1), CKMT1B(1), CKMT2(1), CPS1(2), DAO(1), EPRS(1), GLUD2(1), GOT2(1), NOS1(1), NOS3(2), P4HA1(1), P4HA2(2), P4HA3(2), PARS2(1), PYCR1(1)	17621763	20	17	20	8	7	7	2	3	1	0	0.706	1.000	1.000
446	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(1), AKT1(3), CHRM1(1), FLT1(1), KDR(4), NOS3(2), PDE3B(1), RYR2(7), SYT1(1), TNNI1(1)	19798558	22	19	21	7	8	6	5	1	2	0	0.637	1.000	1.000
447	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	37	AKT1(3), ATF2(2), DUSP4(1), DUSP8(1), GCK(1), MAP2K4(2), MAP3K12(3), MAP3K13(1), MAP3K3(1), MAP3K4(1), MAP3K7(1), MAP3K9(1), MAPK10(1), MAPK9(1), PAPPA(2), SHC1(1)	24382359	23	19	22	7	8	6	3	3	3	0	0.594	1.000	1.000
448	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	31	AKT1(3), BAD(1), BTK(1), INPP5D(1), PDK1(1), RPS6KA3(1), SHC1(1)	16292561	9	7	8	6	2	4	2	0	1	0	0.953	1.000	1.000
449	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSD(1), ARSE(1), GAL3ST1(1), LCT(1), NEU4(1), PPAP2A(1), SGMS1(1), SMPD2(2), SPTLC2(1)	17471896	10	9	10	6	2	2	1	4	1	0	0.921	1.000	1.000
450	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(1), ATP6V0A1(1), ATP6V0D1(1), ATP6V1A(2), ATP6V1B2(1), ATP6V1C2(3), ATP7A(1), ATP7B(2), COX10(1), COX7A1(1), NDUFA10(1), NDUFS2(1), SDHA(1), SDHB(1), UQCRC1(1), UQCRFS1(1)	18807063	20	16	20	7	8	4	4	3	1	0	0.659	1.000	1.000
451	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(3), ARHGEF11(2), DLG4(1), GNA13(1), MAP2K4(2), NFKB1(2), NFKBIB(1), PDK1(1), PIK3CB(2), PLD1(2), ROCK1(4), ROCK2(1)	24176880	22	21	20	6	5	5	3	6	3	0	0.527	1.000	1.000
452	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CD14(1), LY96(1), MAP2K4(2), MAP3K7(1), NFKB1(2), RELA(2)	17833754	9	9	9	4	2	3	0	3	1	0	0.834	1.000	1.000
453	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	27	CPEB1(1), EGFR(4), ERBB4(2), ETV6(1), ETV7(1), FMN2(2), NOTCH2(2), NOTCH4(2), PIWIL1(4), PIWIL2(1), PIWIL3(2)	24911267	22	21	22	7	6	4	4	5	3	0	0.714	1.000	1.000
454	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	33	ADCY1(1), NFATC2(1), NFATC4(1), PPP3CA(1), PPP3CC(1), PRKCA(1), RPS6KA3(1), SYT1(1)	16898193	8	6	8	4	4	0	1	2	1	0	0.858	1.000	1.000
455	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	61	APAF1(1), BAI1(2), CCNE2(1), CCNG1(1), CCNG2(1), FAS(1), GTSE1(1), MDM4(1), RCHY1(1), RRM2B(1), SERPINB5(1), SESN1(1), SESN2(1), SESN3(1), THBS1(1), TNFRSF10B(1), TSC2(1)	28209540	18	18	18	9	0	5	2	7	4	0	0.965	1.000	1.000
456	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	32	ACTA1(1), CRK(1), DOCK1(1), HGF(3), ITGA1(1), MET(3), STAT3(3)	19963984	13	13	13	7	2	1	2	7	1	0	0.934	1.000	1.000
457	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	34	ACTA1(1), BCR(1), CAPNS1(1), ITGA1(1), ROCK1(4), SHC1(1), TLN1(2)	22961109	11	10	10	5	0	1	2	6	2	0	0.886	1.000	1.000
458	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ADCY8(2), CACNA1A(2), CACNA1B(1), GNB3(1), PRKACA(1), SCNN1B(2), TAS2R4(1), TAS2R5(1), TAS2R60(2)	27920857	13	12	13	9	2	1	0	7	3	0	0.987	1.000	1.000
459	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	35	BTK(1), FCER1A(1), LYN(1), MAP2K4(2), NFATC2(1), NFATC4(1), PAK2(1), PLA2G4A(1), PPP3CA(1), PPP3CC(1), SHC1(1), SYK(2), SYT1(1)	19862897	15	12	15	7	6	4	1	3	1	0	0.870	1.000	1.000
460	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	88	ACVR1B(1), ACVR1C(1), ACVR2A(1), ACVRL1(1), BMP4(1), BMP6(1), BMPR1A(1), BMPR1B(1), BMPR2(1), COMP(1), CREBBP(2), DCN(1), FST(1), GDF6(1), INHBA(2), INHBE(1), LTBP1(3), PPP2R1B(1), PPP2R2B(3), PPP2R2C(1), RBL1(1), RBL2(2), ROCK1(4), ROCK2(1), RPS6KB2(1), SMAD2(1), SMAD3(1), SMAD4(4), SMAD6(1), SMAD9(1), SMURF2(1), SP1(2), TFDP1(1), TGFBR1(1), THBS1(1), THBS3(1), ZFYVE16(1), ZFYVE9(1)	48704950	52	45	51	11	8	14	5	20	5	0	0.218	1.000	1.000
461	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	57	APC(2), DVL3(1), FZD2(3), FZD5(1), FZD6(3), FZD7(1), FZD9(1), LDLR(1), MAPK10(1), MAPK9(1), PPP2R5E(2), PRKCA(1), PRKCG(1), PRKD1(1), RAC1(1), WNT2(1), WNT6(1)	28758732	23	21	23	9	4	9	1	6	3	0	0.749	1.000	1.000
462	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	B3GALT2(1), B3GALT4(1), B3GNT2(1), B3GNT3(1), B3GNT4(1), B4GALNT1(1), B4GALT2(1), B4GALT4(1), GBGT1(1), PIGA(1), PIGO(1), PIGT(1), ST3GAL1(1), ST3GAL6(1), ST6GALNAC4(1), ST6GALNAC5(1), ST8SIA5(1)	23853211	17	15	17	9	6	6	1	3	0	1	0.889	1.000	1.000
463	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(2), CREBBP(2), ERCC3(1), GRIP1(1), GTF2A1(1), HDAC3(2), HDAC6(2), MEF2C(1), NRIP1(2)	22398681	14	12	14	5	3	3	1	6	1	0	0.713	1.000	1.000
464	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	CARS(1), EPRS(1), GARS(1), HARS(1), LARS(1), LARS2(1), MARS(1), MARS2(1), PARS2(1), QARS(2), TARS2(1), VARS(1), VARS2(1)	26718219	14	13	14	6	6	3	0	4	1	0	0.824	1.000	1.000
465	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	CREBBP(2), DLL4(2), DTX1(1), DTX3L(1), DVL3(1), JAG1(1), JAG2(2), MAML1(1), MAML2(1), MAML3(3), MFNG(1), NOTCH2(2), NOTCH4(2), NUMB(1), NUMBL(1), RBPJ(1), SNW1(1)	33968062	24	18	24	9	8	6	0	7	3	0	0.715	1.000	1.000
466	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(3), CAPN3(1), CAPN5(1), CAPN6(1), CAPN7(1), CAPN9(1), CAPNS1(1), CAV3(1), CRK(1), DOCK1(1), GIT2(1), ITGA10(2), ITGA2(2), ITGA2B(1), ITGA3(1), ITGA4(1), ITGA6(1), ITGA8(2), ITGA9(2), ITGAD(2), ITGAL(2), ITGAM(1), ITGAV(1), ITGAX(3), ITGB2(1), ITGB4(1), ITGB5(1), ITGB6(2), MAPK10(1), MYLK2(3), PAK2(1), PAK6(2), PIK3R2(1), RAC1(1), RAC2(1), RAC3(1), ROCK1(4), ROCK2(1), SHC1(1), SORBS1(2), TLN1(2), TNS1(4), VAV2(2), VAV3(3)	65756261	69	58	67	15	9	24	10	18	8	0	0.132	1.000	1.000
467	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	42	ACTR3(1), AKT1(3), ARHGEF11(2), BTK(1), CFL1(1), CFL2(1), INPPL1(1), ITPR1(1), ITPR2(5), LIMK1(1), MYLK(3), MYLK2(3), PAK2(1), PAK6(2), PDK1(1), PIK3CD(2), PIK3CG(1), ROCK1(4), ROCK2(1), SAG(2), WASF1(1)	32995554	38	33	36	10	7	11	4	9	7	0	0.508	1.000	1.000
468	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	64	ADCY1(1), ADCY8(2), ATF4(1), CACNA1C(2), CAMK2D(1), CREBBP(2), GRIA1(3), GRIA2(1), GRIN1(1), GRIN2A(6), GRIN2B(5), GRM1(4), GRM5(1), ITPR1(1), ITPR2(5), PLCB1(3), PPP1CA(1), PPP3CA(1), PPP3CC(1), PRKACA(1), PRKCA(1), PRKCG(1), RPS6KA3(1), RPS6KA6(1)	46563027	47	45	47	12	8	11	8	13	7	0	0.473	1.000	1.000
469	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	162	ADORA3(2), ADRA1B(1), ADRA1D(2), ADRA2C(1), ADRB2(1), AGTR1(1), AVPR1A(3), AVPR1B(1), BRS3(1), CCKAR(1), CCKBR(1), CCR1(1), CCR2(3), CCR4(1), CCRL2(1), CHRM1(1), CHRM2(2), CHRM3(1), CMKLR1(1), CNR1(1), DRD2(1), DRD3(1), F2R(1), GPR17(1), GPR174(1), GPR37L1(3), GPR50(2), GPR83(2), GPR87(3), HCRTR2(2), HTR1D(1), HTR5A(1), HTR6(1), HTR7(1), LHCGR(1), MAS1(1), MC4R(1), MTNR1B(1), NMUR2(1), NPY1R(1), NPY2R(2), OPRL1(1), OR12D3(1), OR1F1(1), OR7A5(2), OXTR(1), P2RY10(1), PTAFR(1), SSTR1(2)	59718654	66	51	66	19	16	26	8	10	6	0	0.178	1.000	1.000
470	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	71	CACNA1A(2), GNA12(1), GNA13(1), GNAI2(1), GNAO1(1), GNAZ(1), GRIA1(3), GRIA2(1), GRIA3(1), GRID2(2), GRM1(4), GRM5(1), GUCY1A2(1), GUCY1A3(1), GUCY2C(1), GUCY2F(1), IGF1R(2), ITPR1(1), ITPR2(5), LYN(1), NOS1(1), NOS3(2), PLA2G2A(1), PLA2G4A(1), PLCB1(3), PPP2R1B(1), PPP2R2B(3), PPP2R2C(1), PRKCA(1), PRKCG(1), RYR1(2)	51845348	49	39	49	13	9	14	5	14	7	0	0.374	1.000	1.000
471	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	187	ACTG1(2), AKT1(3), ARHGAP5(2), BAD(1), BIRC2(1), CAV3(1), COL11A1(7), COL11A2(3), COL1A1(1), COL1A2(1), COL3A1(2), COL4A1(1), COL4A2(2), COL4A4(2), COL5A2(1), COL5A3(2), COL6A1(1), COL6A3(5), COL6A6(2), COMP(1), CRK(1), DOCK1(1), EGF(2), EGFR(4), FARP2(2), FIGF(1), FLNB(1), FLNC(2), FLT1(1), FN1(3), HGF(3), IGF1R(2), ITGA1(1), ITGA10(2), ITGA2(2), ITGA2B(1), ITGA3(1), ITGA4(1), ITGA6(1), ITGA8(2), ITGA9(2), ITGAV(1), ITGB4(1), ITGB5(1), ITGB6(2), KDR(4), LAMA1(2), LAMA2(4), LAMA4(1), LAMA5(2), LAMB1(4), LAMB3(1), LAMC1(3), LAMC2(3), MAPK10(1), MAPK9(1), MET(3), MYLK(3), MYLK2(3), PAK2(1), PAK6(2), PARVB(1), PARVG(1), PDGFD(1), PIK3CB(2), PIK3CD(2), PIK3CG(1), PIK3R2(1), PIK3R3(1), PPP1CA(1), PRKCA(1), PRKCG(1), RAC1(1), RAC2(1), RAC3(1), RELN(2), ROCK1(4), ROCK2(1), SHC1(1), SHC2(1), THBS1(1), THBS3(1), TLN1(2), TLN2(1), TNC(3), TNN(1), TNXB(5), VAV2(2), VAV3(3), VWF(5)	178903398	169	114	166	50	36	56	17	41	19	0	0.451	1.000	1.000
472	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	200	APC(2), ARHGEF1(2), ARPC4(1), ARPC5L(1), CD14(1), CFL1(1), CFL2(1), CHRM1(1), CHRM2(2), CHRM3(1), CRK(1), CYFIP1(1), CYFIP2(1), DIAPH3(1), DOCK1(1), EGF(2), EGFR(4), EZR(1), F2(1), F2R(1), FGD1(1), FGF10(1), FGF3(1), FGF4(1), FGF5(1), FGF7(1), FN1(3), GNA12(1), GNA13(1), IQGAP1(3), IQGAP2(1), ITGA1(1), ITGA10(2), ITGA2(2), ITGA2B(1), ITGA3(1), ITGA4(1), ITGA6(1), ITGA8(2), ITGA9(2), ITGAD(2), ITGAL(2), ITGAM(1), ITGAV(1), ITGAX(3), ITGB2(1), ITGB4(1), ITGB5(1), ITGB6(2), LIMK1(1), LIMK2(1), MSN(1), MYH10(3), MYH9(3), MYLK(3), MYLK2(3), NCKAP1L(1), PAK2(1), PAK6(2), PFN1(1), PFN2(2), PIK3CB(2), PIK3CD(2), PIK3CG(1), PIK3R2(1), PIK3R3(1), PIP4K2B(1), PIP5K1A(1), PPP1CA(1), RAC1(1), RAC2(1), RAC3(1), ROCK1(4), ROCK2(1), RRAS2(1), SLC9A1(1), SSH1(1), SSH2(6), SSH3(2), TIAM1(1), TIAM2(1), VAV2(2), VAV3(3), WAS(1), WASF1(1), WASF2(1)	133443453	130	96	129	34	26	36	17	33	18	0	0.226	1.000	1.000
473	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	167	ADCY1(1), ADCY2(1), ADCY3(1), ADCY7(1), ADCY8(2), ADRA1B(1), ADRA1D(2), ADRB2(1), AGTR1(1), ATP2A2(2), ATP2B1(1), ATP2B2(3), ATP2B4(3), AVPR1A(3), AVPR1B(1), CACNA1A(2), CACNA1B(1), CACNA1C(2), CACNA1D(1), CACNA1E(6), CACNA1S(2), CAMK2D(1), CCKAR(1), CCKBR(1), CHRM1(1), CHRM2(2), CHRM3(1), CYSLTR1(1), EGFR(4), ERBB3(2), ERBB4(2), F2R(1), GRIN1(1), GRIN2A(6), GRM1(4), GRM5(1), HTR5A(1), HTR6(1), HTR7(1), ITPKB(1), ITPR1(1), ITPR2(5), LHCGR(1), MYLK(3), MYLK2(3), NOS1(1), NOS3(2), OXTR(1), P2RX2(1), P2RX5(1), PDE1B(1), PDE1C(1), PHKA1(1), PHKB(1), PLCB1(3), PLCE1(1), PLCG2(1), PLCZ1(1), PPP3CA(1), PPP3CC(1), PRKACA(1), PRKCA(1), PRKCG(1), PTAFR(1), RYR1(2), RYR2(7), RYR3(4), SLC8A1(2), TACR1(1), TACR3(3)	130452238	125	95	125	49	26	35	18	31	15	0	0.921	1.000	1.000
474	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	236	ADORA3(2), ADRA1B(1), ADRA2C(1), ADRB2(1), AGTR1(1), AVPR1A(3), AVPR1B(1), BRS3(1), CCKAR(1), CCKBR(1), CHRM1(1), CHRM2(2), CHRM3(1), CNR1(1), CYSLTR1(1), DRD2(1), DRD3(1), F2(1), F2R(1), GABBR2(1), GABRA4(1), GABRB1(2), GABRB2(1), GABRD(1), GABRE(2), GABRG1(2), GABRR2(1), GH1(1), GH2(1), GHR(2), GHRHR(1), GIPR(1), GLP1R(1), GLP2R(3), GLRA2(1), GLRB(1), GPR50(2), GPR83(2), GRIA1(3), GRIA2(1), GRIA3(1), GRIA4(2), GRID1(2), GRID2(2), GRIK1(1), GRIK3(3), GRIK4(2), GRIN1(1), GRIN2A(6), GRIN2B(5), GRIN3A(2), GRM1(4), GRM2(1), GRM5(1), GRM8(1), HCRTR2(2), HTR1D(1), HTR5A(1), HTR6(1), HTR7(1), LEPR(1), LHCGR(1), MAS1(1), MC4R(1), MTNR1B(1), NMUR2(1), NPY1R(1), NPY2R(2), OPRL1(1), OXTR(1), P2RX2(1), P2RX5(1), P2RY10(1), PRLR(2), PRSS3(1), PTAFR(1), PTH2R(2), RXFP1(1), SSTR1(2), TAAR1(1), TAAR2(1), TAAR6(1), TAAR8(1), TACR1(1), TACR3(3), TSHR(1), VIPR1(1)	109101381	127	90	127	36	31	38	20	25	13	0	0.194	1.000	1.000
475	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	244	ACVR1B(1), ACVR1C(1), AKT1(3), ATF2(2), ATF4(1), CACNA1A(2), CACNA1B(1), CACNA1C(2), CACNA1D(1), CACNA1E(6), CACNA1S(2), CACNA2D1(2), CACNA2D3(1), CACNB1(2), CACNB2(1), CACNB4(1), CACNG7(2), CD14(1), CRK(1), DAXX(1), DUSP1(1), DUSP16(1), DUSP4(1), DUSP7(1), DUSP8(1), DUSP9(1), EGF(2), EGFR(4), FAS(1), FASLG(1), FGF10(1), FGF3(1), FGF4(1), FGF5(1), FGF7(1), FLNB(1), FLNC(2), GNA12(1), MAP2K4(2), MAP3K12(3), MAP3K13(1), MAP3K3(1), MAP3K4(1), MAP3K6(1), MAP3K7(1), MAPK10(1), MAPK9(1), MAPKAPK3(1), MAPKAPK5(1), MEF2C(1), NF1(1), NFATC2(1), NFATC4(1), NFKB1(2), NTRK1(1), PAK2(1), PLA2G2A(1), PLA2G4A(1), PPM1A(1), PPP3CA(1), PPP3CC(1), PPP5C(1), PRKACA(1), PRKCA(1), PRKCG(1), PTPRR(1), RAC1(1), RAC2(1), RAC3(1), RAPGEF2(2), RASA2(1), RASGRF1(1), RASGRF2(2), RPS6KA3(1), RPS6KA5(2), RPS6KA6(1), RRAS2(1), STK4(1), TAOK1(1), TAOK2(1), TAOK3(1), TGFBR1(1), TRAF2(1)	138489753	109	86	108	39	29	24	9	31	16	0	0.797	1.000	1.000
476	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	136	ACTG1(2), COL11A1(7), COL11A2(3), COL17A1(2), COL1A1(1), COL1A2(1), COL3A1(2), COL4A1(1), COL4A2(2), COL4A4(2), COL5A2(1), COL5A3(2), COL6A1(1), COL6A3(5), COL6A6(2), COMP(1), DSC3(1), DSG1(1), DSG2(2), DSG4(1), FN1(3), GJB5(1), ITGA6(1), ITGB4(1), KRT12(1), KRT13(1), KRT14(1), KRT16(1), KRT18(1), KRT19(1), KRT23(1), KRT25(3), KRT27(3), KRT28(1), KRT5(1), KRT6C(3), KRT72(1), KRT73(1), KRT75(1), KRT78(2), KRT79(1), KRT83(1), KRT84(1), KRT85(1), KRT9(1), LAMA1(2), LAMA2(4), LAMA4(1), LAMA5(2), LAMB1(4), LAMB3(1), LAMC1(3), LAMC2(3), LMNA(1), NES(3), RELN(2), THBS1(1), THBS3(1), TNC(3), TNN(1), TNXB(5), VWF(5)	122045260	116	78	115	34	30	41	8	19	18	0	0.369	1.000	1.000
477	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	COL11A1(7), COL11A2(3), COL1A1(1), COL1A2(1), COL3A1(2), COL4A1(1), COL4A2(2), COL4A4(2), COL5A2(1), COL5A3(2), COL6A1(1), COL6A3(5), COL6A6(2), DAG1(2), FN1(3), FNDC1(2), FNDC3A(1), GP5(2), HSPG2(3), ITGA1(1), ITGA10(2), ITGA2(2), ITGA2B(1), ITGA3(1), ITGA4(1), ITGA6(1), ITGA8(2), ITGA9(2), ITGAV(1), ITGB4(1), ITGB5(1), ITGB6(2), LAMA1(2), LAMA2(4), LAMA4(1), LAMA5(2), LAMB1(4), LAMB3(1), LAMC1(3), LAMC2(3), RELN(2), SDC1(1), SV2A(1), SV2B(1), THBS1(1), THBS3(1), TNC(3), TNN(1), TNXB(5), VWF(5)	109787461	102	71	101	30	24	34	11	21	12	0	0.483	1.000	1.000
478	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	126	ABL1(1), CFL1(1), CFL2(1), DPYSL2(1), EFNA3(1), EFNA5(1), EPHA3(5), EPHA4(1), EPHA5(1), EPHA6(2), EPHA7(1), EPHB1(2), EPHB3(1), FES(3), GNAI2(1), L1CAM(2), LIMK1(1), LIMK2(1), LRRC4C(1), MET(3), NFATC2(1), NFATC4(1), NRP1(1), NTNG1(2), PAK2(1), PAK6(2), PLXNA1(1), PLXNA2(2), PLXNB1(1), PLXNB2(1), PLXNC1(3), PPP3CA(1), PPP3CC(1), RAC1(1), RAC2(1), RAC3(1), ROBO1(4), ROBO2(3), ROBO3(1), ROCK1(4), ROCK2(1), SEMA3A(1), SEMA3D(1), SEMA3E(2), SEMA3F(1), SEMA4C(3), SEMA6A(1), SEMA6C(1), SEMA6D(2), SLIT1(2), SLIT3(2), SRGAP1(2), SRGAP3(2), UNC5A(1), UNC5B(1), UNC5D(1)	96377736	88	65	87	30	18	24	11	24	11	0	0.724	1.000	1.000
479	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	128	ACTG1(2), AKT1(3), ASH1L(7), CLDN20(1), CLDN9(1), CSNK2A1(1), CSNK2A2(1), CTNNA1(1), CTNNA2(1), EPB41L1(1), EPB41L2(1), EPB41L3(3), EXOC4(2), GNAI2(1), INADL(2), MAGI1(1), MAGI2(1), MLLT4(2), MPDZ(3), MYH1(3), MYH10(3), MYH11(1), MYH13(1), MYH15(1), MYH4(5), MYH6(5), MYH7(1), MYH7B(1), MYH8(4), MYH9(3), PPP2R1B(1), PPP2R2B(3), PPP2R2C(1), PPP2R3A(1), PPP2R3B(1), PPP2R4(1), PRKCA(1), PRKCG(1), RAB13(1), RRAS2(1), SPTAN1(1), TJP1(2), TJP2(2), TJP3(1), VAPA(2), YES1(1)	94095492	84	63	83	23	16	26	9	20	13	0	0.339	1.000	1.000
480	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(1), ADCY2(1), ADCY3(1), ADCY7(1), ADCY8(2), ADRA1B(1), ADRA1D(2), ADRB2(1), ANXA6(2), ATP2A2(2), ATP2B1(1), ATP2B2(3), CACNA1A(2), CACNA1B(1), CACNA1C(2), CACNA1D(1), CACNA1E(6), CACNA1S(2), CACNB1(2), CAMK1(1), CAMK2D(1), CHRM1(1), CHRM2(2), CHRM3(1), GJB5(1), GNAI2(1), GNAO1(1), GNAZ(1), GNB3(1), GNB5(2), ITPR1(1), ITPR2(5), MIB1(1), PRKACA(1), PRKCA(1), PRKCG(1), PRKD1(1), RGS10(1), RGS9(1), RYR1(2), RYR2(7), RYR3(4), SLC8A1(2)	91863727	75	60	75	39	10	21	12	19	13	0	0.999	1.000	1.000
481	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	141	APC(2), CACYBP(1), CAMK2D(1), CREBBP(2), CSNK2A1(1), CSNK2A2(1), DAAM1(2), DAAM2(1), DKK1(2), DVL3(1), FBXW11(2), FZD2(3), FZD4(2), FZD5(1), FZD6(3), FZD7(1), FZD9(1), LEF1(1), MAP3K7(1), MAPK10(1), MAPK9(1), NFATC2(1), NFATC4(1), PLCB1(3), PPP2R1B(1), PPP2R2B(3), PPP2R2C(1), PPP3CA(1), PPP3CC(1), PRICKLE2(1), PRKACA(1), PRKCA(1), PRKCG(1), RAC1(1), RAC2(1), RAC3(1), ROCK1(4), ROCK2(1), SFRP2(1), SMAD2(1), SMAD3(1), SMAD4(4), SOX17(1), TBL1XR1(2), TCF7L1(1), TCF7L2(1), WIF1(2), WNT2(1), WNT6(1), WNT9A(1)	77235371	72	58	71	32	12	22	6	20	12	0	0.974	1.000	1.000
482	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	130	ALCAM(1), CADM1(1), CD34(1), CD40(1), CD6(1), CD8A(1), CD8B(1), CDH1(2), CDH2(2), CDH3(2), CDH4(1), CDH5(4), CLDN20(1), CLDN9(1), CNTN2(1), CNTNAP1(4), CNTNAP2(1), HLA-DMB(1), HLA-DQA2(1), HLA-G(1), ICAM3(1), ITGA4(1), ITGA6(1), ITGA8(2), ITGA9(2), ITGAL(2), ITGAM(1), ITGAV(1), ITGB2(1), L1CAM(2), MAG(1), NCAM1(1), NCAM2(2), NEGR1(1), NEO1(1), NRCAM(2), NRXN1(1), NRXN2(1), NRXN3(2), PTPRC(3), PTPRM(1), PVRL1(1), PVRL2(1), SDC1(1), SELE(2), SELP(2), SIGLEC1(1), SPN(1), VCAM1(1), VCAN(4)	72339475	73	57	73	22	14	28	6	15	10	0	0.434	1.000	1.000
483	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	150	AKT1(3), CREBBP(2), CSF2RA(1), GH1(1), GH2(1), GHR(2), IFNA10(1), IFNA13(1), IFNA16(2), IFNA17(1), IFNA21(1), IFNA6(1), IFNB1(1), IL10RA(1), IL12A(1), IL12RB2(1), IL13RA1(1), IL20(1), IL21(1), IL22(1), IL23A(1), IL3RA(1), IL4R(3), IL5RA(1), IL6ST(3), IL7(1), IL7R(1), IL9(1), JAK1(2), JAK3(2), LEPR(1), LIF(1), LIFR(3), PIAS3(1), PIAS4(1), PIK3CB(2), PIK3CD(2), PIK3CG(1), PIK3R2(1), PIK3R3(1), PRLR(2), SOCS4(2), SPRY3(1), STAT1(1), STAT2(1), STAT3(3), STAT4(3), STAT5A(1), STAT5B(1), TPO(1), TYK2(1)	70470730	72	55	71	20	17	11	9	22	13	0	0.580	1.000	1.000
484	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ACTA1(1), ADCY1(1), ADCY2(1), ADCY3(1), ADCY7(1), ADCY8(2), ATF2(2), ATF4(1), ATP2A2(2), CAMK2D(1), DGKZ(1), GBA2(1), GNB3(1), GNB5(2), GSTO1(1), GUCY1A3(1), IGFBP6(1), ITPR1(1), ITPR2(5), MIB1(1), MYLK2(3), NFKB1(2), NOS1(1), NOS3(2), OXTR(1), PLCG2(1), PRKACA(1), PRKCA(1), PRKD1(1), RGS10(1), RGS9(1), RYR1(2), RYR2(7), RYR3(4), SLC8A1(2), SP1(2), TNXB(5)	84868972	65	54	65	37	11	17	11	15	11	0	0.999	1.000	1.000
485	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	74	ACP1(1), ACTG1(2), ACVR1B(1), ACVR1C(1), CDH1(2), CREBBP(2), CSNK2A1(1), CSNK2A2(1), CTNNA1(1), CTNNA2(1), EGFR(4), FARP2(2), FER(3), IGF1R(2), INSR(1), IQGAP1(3), LEF1(1), LMO7(2), MAP3K7(1), MET(3), MLLT4(2), PTPRB(1), PTPRM(1), PVRL1(1), PVRL2(1), RAC1(1), RAC2(1), RAC3(1), SMAD2(1), SMAD3(1), SMAD4(4), SNAI1(1), SORBS1(2), SSX2IP(1), TCF7L1(1), TCF7L2(1), TGFBR1(1), TJP1(2), WAS(1), WASF1(1), WASF2(1), WASF3(1), YES1(1)	58122450	64	53	64	18	11	14	8	25	6	0	0.494	1.000	1.000
486	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	128	ACACA(1), ACACB(1), AKT1(3), BAD(1), CRK(1), FASN(1), G6PC2(1), GCK(1), GYS1(1), INPP5D(1), INSR(1), IRS1(2), MAPK10(1), MAPK9(1), PCK2(1), PDE3B(1), PFKL(2), PFKM(2), PFKP(2), PHKA1(1), PHKB(1), PIK3CB(2), PIK3CD(2), PIK3CG(1), PIK3R2(1), PIK3R3(1), PPP1CA(1), PPP1R3A(4), PPP1R3B(2), PRKAA2(2), PRKACA(1), PRKAG1(2), PRKAG2(1), PYGL(1), RPS6KB2(1), SHC1(1), SHC2(1), SOCS4(2), SORBS1(2), TRIP10(1), TSC2(1)	76462337	57	52	56	22	6	17	4	20	10	0	0.893	1.000	1.000
487	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(1), DMD(2), MYBPC2(2), MYBPC3(1), MYH6(5), MYH7(1), MYH8(4), MYL1(1), MYOM1(1), NEB(5), TNNI1(1), TPM4(1), TTN(43)	66721237	68	52	68	17	16	20	4	19	9	0	0.373	1.000	1.000
488	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	123	CD244(1), CD48(4), FAS(1), FASLG(1), HLA-G(1), IFNA10(1), IFNA13(1), IFNA16(2), IFNA17(1), IFNA21(1), IFNA6(1), IFNB1(1), ITGAL(2), ITGB2(1), KIR3DL1(2), LCP2(2), MICB(1), NCR1(2), NCR2(1), NFATC2(1), NFATC4(1), PIK3CB(2), PIK3CD(2), PIK3CG(1), PIK3R2(1), PIK3R3(1), PLCG2(1), PPP3CA(1), PPP3CC(1), PRKCA(1), PRKCG(1), RAC1(1), RAC2(1), RAC3(1), SH3BP2(1), SHC1(1), SHC2(1), SYK(2), TNFRSF10A(1), TNFRSF10B(1), ULBP3(1), VAV2(2), VAV3(3), ZAP70(2)	53652046	59	48	59	22	12	22	4	13	8	0	0.816	1.000	1.000
489	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	108	ARHGAP5(2), CDH5(4), CLDN20(1), CLDN9(1), CTNNA1(1), CTNNA2(1), CYBB(1), EZR(1), GNAI2(1), ITGA4(1), ITGAL(2), ITGAM(1), ITGB2(1), MLLT4(2), MMP2(1), MMP9(2), MSN(1), NCF2(1), PIK3CB(2), PIK3CD(2), PIK3CG(1), PIK3R2(1), PIK3R3(1), PLCG2(1), PRKCA(1), PRKCG(1), RAC1(1), RAC2(1), RAPGEF4(2), ROCK1(4), ROCK2(1), SIPA1(2), VAV2(2), VAV3(3), VCAM1(1)	59061866	52	47	51	20	6	18	5	15	8	0	0.849	1.000	1.000
490	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADA(1), ADCY1(1), ADCY2(1), ADCY3(1), ADCY7(1), ADCY8(2), AK7(1), AMPD1(3), AMPD2(2), APRT(1), ATIC(3), CANT1(1), DGUOK(1), ENPP1(2), ENPP3(1), ENTPD3(1), ENTPD6(1), ENTPD8(1), FHIT(1), GART(1), GUCY1A2(1), GUCY1A3(1), GUCY2C(1), GUCY2F(1), NME1(1), NT5E(1), PAPSS2(1), PDE10A(4), PDE1C(1), PDE3B(1), PDE8A(3), PDE9A(1), POLA1(1), POLD3(1), POLE(3), POLR1A(2), POLR1B(1), POLR1C(1), POLR2B(1), POLR3A(2), PRIM2(1), PRPS1L1(3), RRM1(3), RRM2B(1)	80285268	64	46	64	16	16	15	6	15	12	0	0.265	1.000	1.000
491	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	75	ABL1(1), ACTR3(1), AKT1(3), CRK(1), DOCK1(1), GRB7(2), ITGA1(1), ITGA10(2), ITGA2(2), ITGA3(1), ITGA4(1), ITGA6(1), ITGA8(2), ITGA9(2), MAP2K4(2), MAPK10(1), MAPK9(1), MYLK(3), MYLK2(3), PAK2(1), PAK6(2), PIK3CB(2), PLCG2(1), ROCK1(4), ROCK2(1), SHC1(1), TLN1(2), TLN2(1), WAS(1)	57904662	47	44	45	16	5	15	6	16	5	0	0.747	1.000	1.000
492	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(2), AMY2B(1), DDX23(1), DDX41(1), DDX47(3), DDX50(3), ENPP1(2), ENPP3(1), ERCC2(2), ERCC3(1), G6PC2(1), GAA(1), GBE1(1), GCK(1), GPI(1), GYS1(1), HK2(1), HK3(1), MGAM(2), MOV10L1(1), PGM3(1), PYGL(1), RAD54B(2), SETX(3), SI(2), SKIV2L2(3), SMARCA2(1), SMARCA5(3), UGT1A1(2), UGT1A3(1), UGT1A7(1), UGT2A3(1), UGT2B11(2), UGT2B15(3), UGT2B28(1), UGT2B7(1)	60923446	56	42	56	15	12	9	7	22	6	0	0.462	1.000	1.000
493	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	67	C1S(2), C3(1), C4BPA(1), C6(4), C9(2), CD46(3), CFB(1), CFH(3), CR1(1), F11(3), F13A1(1), F13B(3), F2(1), F2R(1), F3(1), F5(4), F8(3), FGA(4), FGB(1), MASP1(1), MASP2(1), PLAT(1), PLG(2), PROC(1), PROS1(2), SERPIND1(1), VWF(5)	44457614	54	42	54	19	15	13	4	16	6	0	0.799	1.000	1.000
494	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADA(1), ADCY1(1), ADCY2(1), ADCY3(1), ADCY7(1), ADCY8(2), AMPD1(3), AMPD2(2), APRT(1), ATIC(3), ATP5A1(2), ATP5J(1), CANT1(1), DGUOK(1), ENPP1(2), ENPP3(1), FHIT(1), GART(1), GUCY1A2(1), GUCY1A3(1), GUCY2C(1), GUCY2F(1), NME1(1), NT5E(1), PAPSS2(1), PDE6C(1), PDE8A(3), PDE9A(1), POLE(3), POLG(1), POLQ(1), POLR1B(1), POLR2B(1), PRPS1L1(3), RRM1(3)	63057677	51	42	51	16	11	13	4	14	9	0	0.633	1.000	1.000
495	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	107	ALG12(1), ALG14(1), B3GNT2(1), B4GALT2(1), B4GALT4(1), CHPF(1), CHST12(1), CHSY1(1), DPAGT1(1), EXT1(1), EXT2(4), EXTL1(1), EXTL3(1), FUT8(1), GALNT10(1), GALNT11(1), GALNT13(1), GALNT14(1), GALNT3(1), GALNT4(1), GALNT8(1), GALNTL5(1), GANAB(1), HS6ST1(1), HS6ST2(1), MAN1A2(1), MAN2A1(3), MGAT5(1), MGAT5B(1), NDST2(2), NDST4(4), OGT(1), ST3GAL1(1), ST6GAL1(2), ST6GALNAC1(1), WBSCR17(1), XYLT1(2)	53893162	48	41	48	17	11	14	1	13	9	0	0.751	1.000	1.000
496	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	90	ADCY1(1), ADCY2(1), ADCY3(1), ADCY7(1), ADCY8(2), DRD2(1), EGF(2), EGFR(4), GNAI2(1), GRM1(4), GRM5(1), GUCY1A2(1), GUCY1A3(1), GUCY2C(1), GUCY2F(1), ITPR1(1), ITPR2(5), PDGFD(1), PLCB1(3), PRKACA(1), PRKCA(1), PRKCG(1), TJP1(2), TUBA1C(1), TUBA3C(3), TUBB1(1), TUBB2B(1), TUBB8(1)	63605089	45	40	45	17	9	13	6	11	6	0	0.787	1.000	1.000
497	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	91	ADCY1(1), ADCY2(1), ADCY3(1), ADCY7(1), ADCY8(2), AKAP1(1), AKAP11(1), AKAP12(1), AKAP2(3), AKAP3(1), AKAP6(2), AKAP8(1), AKAP9(2), ARHGEF1(2), GNA12(1), GNA13(1), GNAI2(1), GNAO1(1), GNAZ(1), GNB3(1), GNB5(2), ITPR1(1), PDE1B(1), PDE1C(1), PDE8A(3), PPP3CA(1), PPP3CC(1), PRKACA(1), PRKCA(1), PRKCG(1), PRKD1(1), PRKD3(2), SLC9A1(1)	57331390	43	38	43	13	8	10	5	14	6	0	0.640	1.000	1.000
498	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	70	CDS1(1), DGKD(3), DGKI(4), DGKQ(1), DGKZ(1), INPP5B(2), INPP5D(1), INPP5E(2), INPPL1(1), ITPKB(1), ITPR1(1), ITPR2(5), OCRL(1), PI4KA(1), PI4KB(1), PIK3C2A(1), PIK3CB(2), PIK3CD(2), PIK3CG(1), PIK3R2(1), PIK3R3(1), PIP4K2B(1), PIP5K1A(1), PLCB1(3), PLCE1(1), PLCG2(1), PLCZ1(1), PRKCA(1), PRKCG(1), SYNJ1(1), SYNJ2(2)	58483112	47	38	47	12	7	13	5	13	9	0	0.384	1.000	1.000
499	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	81	ABL1(1), AKT1(3), BAD(1), CAMK2D(1), CRK(1), EGF(2), EGFR(4), ERBB3(2), ERBB4(2), MAP2K4(2), MAPK10(1), MAPK9(1), NRG2(1), PAK2(1), PAK6(2), PIK3CB(2), PIK3CD(2), PIK3CG(1), PIK3R2(1), PIK3R3(1), PLCG2(1), PRKCA(1), PRKCG(1), RPS6KB2(1), SHC1(1), SHC2(1), STAT5A(1), STAT5B(1)	48234681	40	37	39	15	8	12	3	14	3	0	0.764	1.000	1.000
500	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	106	ABL1(1), ANAPC1(2), ANAPC2(1), ANAPC4(1), ANAPC5(1), ANAPC7(1), BUB1(1), BUB1B(1), CCNE2(1), CCNH(1), CDC14B(1), CDC16(1), CDC20(2), CDC27(1), CDC6(1), CDC7(2), CREBBP(2), E2F3(1), ESPL1(1), FZR1(1), MCM2(1), MCM3(1), MCM4(1), MCM5(1), MCM6(1), MCM7(1), PLK1(1), PRKDC(3), RB1(2), RBL1(1), RBL2(2), SMAD2(1), SMAD3(1), SMAD4(4), TFDP1(1)	63099221	46	37	46	15	10	6	5	21	4	0	0.772	1.000	1.000
501	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	93	ADCY1(1), ADCY2(1), ADCY3(1), ADCY7(1), ADCY8(2), ATF4(1), CACNA1C(2), CACNA1D(1), CACNA1S(2), CAMK2D(1), EGFR(4), ITPR1(1), ITPR2(5), MAP2K4(2), MAP3K3(1), MAP3K4(1), MAPK10(1), MAPK9(1), MMP2(1), PLA2G2A(1), PLA2G4A(1), PLCB1(3), PLD1(2), PRKACA(1), PRKCA(1)	60659944	39	37	39	21	10	9	4	10	6	0	0.983	1.000	1.000
502	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	83	ANPEP(1), CD14(1), CD1B(1), CD1C(2), CD34(1), CD37(1), CD8A(1), CD8B(1), CR1(1), CSF1R(2), CSF2RA(1), DNTT(1), FCER2(1), FCGR1A(1), FLT3(1), GP5(2), IL3RA(1), IL4R(3), IL5RA(1), IL7(1), IL7R(1), ITGA1(1), ITGA2(2), ITGA2B(1), ITGA3(1), ITGA4(1), ITGA6(1), ITGAM(1), MME(2), TPO(1)	40052947	37	35	37	18	5	10	8	8	6	0	0.979	1.000	1.000
503	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(2), ABCA10(1), ABCA12(1), ABCA13(4), ABCA3(1), ABCA4(4), ABCA5(5), ABCA7(3), ABCA8(1), ABCA9(2), ABCB11(2), ABCB5(1), ABCB6(1), ABCB7(1), ABCC10(2), ABCC11(1), ABCC12(1), ABCC4(1), ABCC5(2), ABCC8(1), ABCC9(2), ABCD3(1), ABCG1(1), ABCG8(1)	57980435	42	34	42	21	7	15	4	8	8	0	0.963	1.000	1.000
504	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	97	AKT1(3), CD14(1), CD40(1), IFNA10(1), IFNA13(1), IFNA16(2), IFNA17(1), IFNA21(1), IFNA6(1), IFNB1(1), IL12A(1), LY96(1), MAP2K4(2), MAP3K7(1), MAPK10(1), MAPK9(1), NFKB1(2), PIK3CB(2), PIK3CD(2), PIK3CG(1), PIK3R2(1), PIK3R3(1), RAC1(1), RELA(2), STAT1(1), TBK1(1), TLR5(1), TLR8(1)	43071631	36	34	35	16	7	8	1	12	8	0	0.952	1.000	1.000
505	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	72	AKT1(3), BTK(1), FCER1A(1), GAB2(3), INPP5D(1), LCP2(2), LYN(1), MAP2K4(2), MAPK10(1), MAPK9(1), PDK1(1), PIK3CB(2), PIK3CD(2), PIK3CG(1), PIK3R2(1), PIK3R3(1), PLA2G2A(1), PLA2G4A(1), PLCG2(1), PRKCA(1), RAC1(1), RAC2(1), RAC3(1), SYK(2), VAV2(2), VAV3(3)	34196510	38	34	37	14	7	14	4	9	4	0	0.756	1.000	1.000
506	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(7), DOT1L(2), EED(1), EHMT2(1), EZH1(2), HCFC1(1), JMJD4(1), KDM6A(6), MEN1(2), NSD1(1), OGT(1), PAXIP1(1), PPP1CA(1), PRDM2(2), PRDM9(1), PRMT1(1), PRMT5(2), RBBP5(1), SETD1A(1), SETD2(3), SETDB1(1), STK38(1), WHSC1L1(1)	58271677	41	33	41	10	7	8	3	10	13	0	0.577	1.000	1.000
507	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	96	ADCY1(1), ADCY2(1), ADCY3(1), ADCY7(1), ADCY8(2), CAMK2D(1), CREB3L2(1), CREB3L3(1), CREBBP(2), DVL3(1), FZD2(3), FZD4(2), FZD5(1), FZD6(3), FZD7(1), FZD9(1), GNAI2(1), GNAO1(1), LEF1(1), PLCB1(3), PRKACA(1), PRKCA(1), PRKCG(1), TCF7L1(1), TCF7L2(1), TYRP1(2), WNT2(1), WNT6(1), WNT9A(1)	51331139	39	33	39	21	7	18	2	8	4	0	0.970	1.000	1.000
508	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	80	ABL1(1), BUB1(1), BUB1B(1), CCNE2(1), CCNH(1), CDC14B(1), CDC20(2), CDC6(1), CDC7(2), CDH1(2), E2F3(1), ESPL1(1), HDAC3(2), HDAC6(2), HDAC8(1), MCM2(1), MCM3(1), MCM4(1), MCM5(1), MCM6(1), MCM7(1), MPEG1(1), PLK1(1), PRKDC(3), PTPRA(1), RB1(2), RBL1(1), SMAD4(4), TFDP1(1)	50310023	40	32	40	12	9	9	4	17	1	0	0.581	1.000	1.000
509	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	60	AKT1(3), BTK(1), CARD11(2), CD72(1), CD81(1), FCGR2B(1), INPP5D(1), LYN(1), NFATC2(1), NFATC4(1), NFKB1(2), NFKBIB(1), PIK3CB(2), PIK3CD(2), PIK3CG(1), PIK3R2(1), PIK3R3(1), PLCG2(1), PPP3CA(1), PPP3CC(1), RAC1(1), RAC2(1), RAC3(1), SYK(2), VAV2(2), VAV3(3)	35304926	36	32	35	18	9	12	3	8	4	0	0.949	1.000	1.000
510	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	90	AKT1(3), CARD11(2), CD8A(1), CD8B(1), LCP2(2), NFATC2(1), NFATC4(1), NFKB1(2), NFKBIB(1), PAK2(1), PAK6(2), PDK1(1), PIK3CB(2), PIK3CD(2), PIK3CG(1), PIK3R2(1), PIK3R3(1), PPP3CA(1), PPP3CC(1), PTPRC(3), VAV2(2), VAV3(3), ZAP70(2)	48669865	37	31	36	20	8	11	4	10	4	0	0.983	1.000	1.000
511	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	91	BAD(1), CNR1(1), CREBBP(2), CSNK2A1(1), FCER1A(1), IFNB1(1), KPNA5(1), MAPK9(1), NFATC2(1), NFATC4(1), NFKBIB(1), NPPB(1), NUP214(1), PPP3CC(1), PTPRC(3), RELA(2), SP1(2), SP3(3), TRAF2(1), TRPV6(1), VAV2(2), VAV3(3), XPO5(3)	44574613	35	30	34	21	11	8	3	9	4	0	0.992	1.000	1.000
512	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	53	ADORA3(2), CCKBR(1), CCR2(3), CELSR2(2), CHRM2(2), CHRM3(1), EMR2(3), EMR3(1), F2R(1), GHRHR(1), GPR116(1), GPR132(1), GPR133(1), GPR17(1), GPR55(1), GPR84(3), GRM1(4), LPHN2(1), LPHN3(4), TSHR(1)	32697889	35	30	34	14	9	11	3	12	0	0	0.662	1.000	1.000
513	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	82	ATF2(2), DAXX(1), MAP2K4(2), MAP3K12(3), MAP3K13(1), MAP3K3(1), MAP3K4(1), MAP3K6(1), MAP3K7(1), MAP3K9(1), MAPK10(1), MAPK9(1), MAPKAPK3(1), MAPKAPK5(1), MEF2C(1), NFKB1(2), PAK2(1), RAC1(1), RELA(2), RPS6KA3(1), RPS6KA5(2), RPS6KB2(1), SHC1(1), SP1(2), STAT1(1), TGFBR1(1), TRAF2(1)	45630610	35	30	35	12	8	8	2	12	5	0	0.698	1.000	1.000
514	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	77	AKT1(3), APAF1(1), BAD(1), BIRC2(1), CFLAR(1), FAS(1), FASLG(1), IL3RA(1), IRAK2(1), NFKB1(2), NTRK1(1), PIK3CB(2), PIK3CD(2), PIK3CG(1), PIK3R2(1), PIK3R3(1), PPP3CA(1), PPP3CC(1), PRKACA(1), RELA(2), TNFRSF10A(1), TNFRSF10B(1), TRAF2(1)	36376136	29	29	28	12	5	10	2	8	4	0	0.884	1.000	1.000
515	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	67	AKT1(3), BAD(1), KDR(4), MAPKAPK3(1), NFATC2(1), NFATC4(1), NOS3(2), PIK3CB(2), PIK3CD(2), PIK3CG(1), PIK3R2(1), PIK3R3(1), PLA2G2A(1), PLA2G4A(1), PLCG2(1), PPP3CA(1), PPP3CC(1), PRKCA(1), PRKCG(1), PTGS2(2), RAC1(1), RAC2(1), RAC3(1), SH2D2A(1), SHC2(1)	34057313	34	29	33	10	9	12	2	7	4	0	0.425	1.000	1.000
516	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	65	ADAM10(2), ATP6V0A1(1), ATP6V0A2(3), ATP6V0D1(1), ATP6V1A(2), ATP6V1B2(1), ATP6V1C2(3), EGFR(4), LYN(1), MAP2K4(2), MAPK10(1), MAPK9(1), MET(3), NFKB1(2), NOD1(1), PLCG2(1), RAC1(1), RELA(2), TCIRG1(1), TJP1(2)	34534831	35	28	35	14	12	5	4	11	3	0	0.804	1.000	1.000
517	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	91	CDC40(1), CLK2(1), CLK3(2), CPSF2(1), CPSF4(1), CSTF2T(1), CSTF3(1), DDX1(1), DHX16(1), DHX9(1), DNAJC8(1), METTL3(3), NXF1(1), PABPN1(1), PPM1G(2), PRPF3(1), PRPF8(1), RBM17(1), RBM5(1), RNMT(1), SF3A1(1), SF3A3(1), SF3B1(1), SNRPA(1), SNRPA1(1), SNRPN(1), SUPT5H(1)	51500545	31	28	31	13	6	8	1	12	4	0	0.885	1.000	1.000
518	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	45	AKT1(3), BAD(1), BCR(1), BTK(1), CD81(1), DAG1(2), INPP5D(1), ITPR1(1), ITPR2(5), LYN(1), NFATC2(1), PDK1(1), PIK3CD(2), PLCG2(1), PPP3CA(1), PPP3CC(1), PTPRC(3), SHC1(1), SYK(2)	35325829	30	28	29	15	5	10	4	7	4	0	0.965	1.000	1.000
519	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG1(2), ACTR3(1), AKT1(3), CFL1(1), CFL2(1), FLNC(2), FSCN2(1), FSCN3(1), LIMK1(1), MYLK(3), MYLK2(3), PAK2(1), PAK6(2), PFN1(1), PFN2(2), ROCK1(4), ROCK2(1), WASF1(1)	23497005	31	28	29	10	4	12	5	7	3	0	0.712	1.000	1.000
520	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	ACAT1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), AOC2(2), AOX1(2), CYP19A1(1), CYP1A1(1), CYP2A13(2), CYP2A6(1), CYP2B6(2), CYP2C19(2), CYP2C8(2), CYP2J2(1), DDC(1), EHHADH(5), KYNU(2), MAOA(1), TPH1(1)	27083187	32	28	32	10	5	7	4	8	8	0	0.679	1.000	1.000
521	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(1), ATP5A1(2), ATP5J(1), ATP6V0A1(1), ATP6V0A2(3), ATP6V0D1(1), ATP6V1A(2), ATP6V1B2(1), ATP6V1C2(3), COX10(1), COX7A1(1), CYC1(1), NDUFA10(1), NDUFA13(1), NDUFB9(1), NDUFS2(1), SDHA(1), SDHB(1), SDHC(2), TCIRG1(1), UQCRC1(1), UQCRFS1(1)	27417503	29	26	29	12	6	5	4	8	6	0	0.881	1.000	1.000
522	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AADAT(1), ACAT1(1), ALDH1A3(1), ALDH1B1(1), AOC2(2), AOX1(2), CYP1A1(1), DDC(1), EHHADH(5), HEMK1(1), HSD17B4(1), KYNU(2), LNX1(1), MAOA(1), METTL6(1), NFX1(1), PRMT3(2), PRMT5(2), TPH1(1)	29749010	28	26	28	12	6	3	2	5	12	0	0.909	1.000	1.000
523	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPP(2), DDX23(1), DDX41(1), DDX47(3), DDX50(3), DHFR(1), ERCC2(2), ERCC3(1), MOV10L1(1), RAD54B(2), SETX(3), SKIV2L2(3), SMARCA2(1), SMARCA5(3), SPR(1)	30924163	28	26	28	11	2	8	3	12	3	0	0.861	1.000	1.000
524	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F11(3), F13B(3), F2(1), F5(4), F8(3), FGA(4), FGB(1), PLAT(1), PLG(2), SERPINB2(1), VWF(5)	17327633	28	24	28	10	9	6	4	6	3	0	0.802	1.000	1.000
525	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	61	CCNE2(1), CCNG2(1), CCNH(1), CREB3L3(1), E2F3(1), GBA2(1), MCM2(1), MCM3(1), MCM4(1), MCM5(1), MCM6(1), MCM7(1), MYT1(1), NACA(1), POLE(3), RB1(2), RBL1(1), RPA1(1), RPA2(1), TFDP1(1), TFDP2(1), TNXB(5)	34312284	29	23	29	10	9	9	1	10	0	0	0.593	1.000	1.000
526	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(3), B3GALT4(1), CDR1(1), DGKI(4), IL6ST(3), RPL11(2), RPL28(1), RPL5(1), RPL7(1), RPS10(1), RPS6KA3(1), RPS6KA6(1), RPS6KB2(1), UBB(1), UBC(1)	25784014	23	21	23	11	5	5	2	3	8	0	0.959	1.000	1.000
527	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), AMD1(1), AOC2(2), ARG2(1), CKB(1), CKMT1B(1), CKMT2(1), CPS1(2), DAO(1), GOT2(1), MAOA(1), NOS1(1), NOS3(2), P4HA1(1), P4HA2(2), P4HA3(2), PYCR1(1)	21659262	26	20	26	10	10	7	3	4	2	0	0.721	1.000	1.000
528	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	31	AKT1(3), BCR(1), BTK(1), ITPR1(1), ITPR2(5), LYN(1), PDK1(1), PLCG2(1), PTPRC(3), RPS6KA3(1), SAG(2), SYK(2)	25685730	22	19	21	14	3	7	2	6	4	0	0.992	1.000	1.000
529	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ALDH1A3(1), ALDH1B1(1), AMDHD1(1), AOC2(2), ASPA(1), CNDP1(1), DDC(1), FTCD(1), HAL(1), HARS(1), HDC(1), HEMK1(1), MAOA(1), METTL6(1), PRMT3(2), PRMT5(2), UROC1(2)	19427958	21	18	21	10	5	5	1	2	8	0	0.907	1.000	1.000
530	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	60	AKT1(3), BAD(1), EBP(1), ERBB4(2), INPPL1(1), IRS1(2), MET(3), PAK2(1), PAK6(2), PDK1(1), PIK3CD(2), RPS6KA3(1), SHC1(1), TSC2(1)	36377991	22	18	21	11	5	6	2	5	4	0	0.929	1.000	1.000
531	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ACAA1(3), ACAA2(1), ACAT1(1), ALDH1A3(1), ALDH1B1(1), AOX1(2), BCKDHA(1), EHHADH(5), HMGCL(2), HMGCS1(2), HSD17B4(1), IVD(1)	21173407	21	17	21	10	4	2	2	5	8	0	0.932	1.000	1.000
532	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	38	AKT1(3), BAD(1), BCR(1), BTK(1), DAG1(2), ITPKB(1), LYN(1), NFKB1(2), NFKBIB(1), PIK3CD(2), PLCG2(1), SHC1(1), SYK(2)	24860432	19	17	18	11	5	9	2	2	1	0	0.945	1.000	1.000
533	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	40	MAP2K4(2), NFATC2(1), NFATC4(1), NFKB1(2), PPP3CA(1), PPP3CC(1), PRKCA(1), RAC1(1), RELA(2), SHC1(1), SYT1(1), ZAP70(2)	22207958	16	15	16	7	5	5	1	5	0	0	0.825	1.000	1.000
534	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	DAG1(2), ITPKB(1), LCP2(2), NFKB1(2), NFKBIB(1), PAK2(1), PAK6(2), PTPRC(3), ZAP70(2)	27454769	16	14	16	10	5	7	1	3	0	0	0.967	1.000	1.000
535	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	49	ACTA1(1), AKT1(3), CAMK1(1), CREBBP(2), F2(1), LIF(1), MEF2C(1), NFATC2(1), NFATC4(1), PPP3CA(1), PPP3CC(1), SYT1(1)	23735160	15	13	14	7	6	2	3	4	0	0	0.863	1.000	1.000
536	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	23	ATF2(2), BCR(1), LYN(1), PAPPA(2), RAC1(1), RPS6KA3(1), SHC1(1), SYK(2), VAV2(2), VAV3(3)	15503746	16	13	16	10	3	4	2	5	2	0	0.975	1.000	1.000
537	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(1), C6(4), ITGA4(1), ITGAL(2), ITGB2(1), SELP(2), VCAM1(1)	12217529	12	12	12	7	3	6	1	2	0	0	0.949	1.000	1.000
538	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	36	CAMK2D(1), F2(1), MYLK(3), PRKCA(1), SHC1(1), STAT1(1), STAT3(3), STAT5A(1), SYT1(1)	20278370	13	11	13	5	5	2	1	5	0	0	0.768	1.000	1.000
539	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	F13A1(1), F2(1), F2R(1), FGA(4), FGB(1), PLAT(1), PLG(2), SERPINB2(1)	6598800	12	11	12	5	3	3	2	4	0	0	0.843	1.000	1.000
540	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(1), ACACB(1), ACAT1(1), ACSS1(2), ACSS2(1), ALDH1A3(1), ALDH1B1(1), ME3(1), PC(1), PCK2(1)	23001149	11	11	11	5	3	1	2	5	0	0	0.860	1.000	1.000
541	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CCNH(1), ERCC3(1), GTF2B(1), GTF2E2(1), POLR1A(2), POLR1B(1), POLR2B(1), TAF13(1), TAF5(1), TAF6(2)	17230596	12	11	12	7	4	1	2	5	0	0	0.957	1.000	1.000
542	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	33	BTK(1), LYN(1), NFATC2(1), NFATC4(1), PPP3CA(1), PPP3CC(1), PRKCA(1), RAC1(1), SHC1(1), SYK(2), SYT1(1)	18567183	12	9	12	6	5	3	1	3	0	0	0.890	1.000	1.000
543	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	20	AKT1(3), BCR(1), MAP2K4(2), STAT1(1), STAT5A(1), STAT5B(1)	12554511	9	9	8	4	1	4	1	3	0	0	0.805	1.000	1.000
544	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(1), GTF2A1(1), GTF2B(1), HDAC3(2), NCOA1(2), NCOA2(1), NCOA3(1)	12225140	9	9	9	4	4	3	0	2	0	0	0.754	1.000	1.000
545	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(1), CREBBP(2), PTPRC(3), ZAP70(2)	11306092	8	8	8	7	2	3	0	3	0	0	0.991	1.000	1.000
546	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	21	ADCY1(1), AKT1(3), BAD(1), IGF1R(2), IL3RA(1)	9727469	8	8	7	4	2	2	1	3	0	0	0.877	1.000	1.000
547	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CR1(1), FCGR2B(1), ITGAL(2), ITGB2(1), PTPRC(3)	7458063	8	8	8	5	3	3	0	2	0	0	0.933	1.000	1.000
548	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(1), CREBBP(2), PTPRC(3), ZAP70(2)	11306092	8	8	8	7	2	3	0	3	0	0	0.991	1.000	1.000
549	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(1), ACAT1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), ME3(1), PC(1)	18189660	9	8	9	4	1	2	3	3	0	0	0.861	1.000	1.000
550	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CREBBP(2), HDAC3(2), NFKB1(2), RELA(2)	10981192	8	8	8	5	3	2	0	3	0	0	0.930	1.000	1.000
551	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	NFATC2(1), NFKB1(2), PPP3CA(1), PPP3CC(1), RELA(2), SYT1(1)	13763110	8	8	8	4	4	1	1	2	0	0	0.853	1.000	1.000
552	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	20	CSNK2A1(1), PRKCA(1), SHC1(1), STAT1(1), STAT3(3), STAT5A(1), STAT5B(1)	13479997	9	7	9	4	3	2	0	4	0	0	0.820	1.000	1.000
553	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(1), PRKAA2(2), PRKAG1(2), PRKAG2(1)	7530757	6	6	6	3	2	0	1	3	0	0	0.908	1.000	1.000
554	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	20	BRCA1(2), CDC34(1), MYT1(1), PRKDC(3)	17104134	7	6	7	6	4	1	1	1	0	0	0.987	1.000	1.000
555	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	ITGA4(1), ITGAL(2), ITGB2(1), SELE(2)	5948612	6	6	6	3	2	2	1	1	0	0	0.883	1.000	1.000
556	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CAPNS1(1), NFATC2(1), PPP3CA(1), PPP3CC(1), PRKCA(1), SYT1(1)	11999370	6	6	6	4	2	0	1	3	0	0	0.935	1.000	1.000
557	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT10(1), GALNT3(1), GALNT4(1), GALNT8(1), ST3GAL1(1), WBSCR17(1)	7095988	6	6	6	3	0	5	0	1	0	0	0.809	1.000	1.000
558	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	27	MAP2K4(2), PRKCA(1), RAC1(1), SHC1(1), SYT1(1)	13764905	6	6	6	3	1	2	0	3	0	0	0.836	1.000	1.000
559	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(2), CETP(1), CYP7A1(1), LDLR(1), LRP1(1), SCARB1(1)	13487550	7	6	7	4	0	4	0	3	0	0	0.913	1.000	1.000
560	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	ITGAL(2), ITGB2(1), PTPRC(3)	5552516	6	6	6	6	1	3	0	2	0	0	0.986	1.000	1.000
561	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	21	CCNH(1), RB1(2), RBL1(1), TFDP1(1)	7735311	5	5	5	4	2	0	0	3	0	0	0.957	1.000	1.000
562	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(2), NCOA1(2), NCOA2(1), PPARG(1)	9116349	6	5	6	4	3	1	0	2	0	0	0.928	1.000	1.000
563	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	PTPRC(3), ZAP70(2)	4460931	5	5	5	4	0	3	0	2	0	0	0.957	1.000	1.000
564	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(1), ARHGAP5(2), CASP1(1)	6372276	4	4	4	3	0	3	1	0	0	0	0.952	1.000	1.000
565	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	18	CSNK2A1(1), SHC1(1), STAT5A(1), STAT5B(1)	10302618	4	4	4	4	2	2	0	0	0	0	0.963	1.000	1.000
566	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(1), ST3GAL1(1), ST6GALNAC2(1), ST6GALNAC4(1)	2770460	4	4	4	3	0	4	0	0	0	0	0.851	1.000	1.000
567	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	NOS3(2), VHL(2)	8344230	4	4	4	4	1	2	1	0	0	0	0.979	1.000	1.000
568	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(1), ACACB(1), FASN(1), OXSM(1)	7690864	4	4	4	4	1	0	1	2	0	0	0.987	1.000	1.000
569	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	LARS(1), LARS2(1), VARS(1), VARS2(1)	9135144	4	4	4	3	1	1	0	2	0	0	0.935	1.000	1.000
570	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT2(1), B4GALT2(1), B4GALT4(1), FUT8(1), ST3GAL1(1)	6130188	5	4	5	6	3	1	0	1	0	0	0.976	1.000	1.000
571	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	14	IL3RA(1), SHC1(1), STAT5A(1), STAT5B(1)	8497681	4	4	4	4	1	2	0	1	0	0	0.965	1.000	1.000
572	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(2), SPN(1), TNFRSF8(1)	6407805	4	4	4	3	3	1	0	0	0	0	0.887	1.000	1.000
573	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CREBBP(2), NCOA3(1)	10193447	3	3	3	4	1	0	0	2	0	0	0.990	1.000	1.000
574	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	LCT(1), PYGL(1), TPI1(1)	6578672	3	3	3	3	2	1	0	0	0	0	0.927	1.000	1.000
575	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B4GALT2(1), FUT8(1), ST3GAL1(1)	3862639	3	3	3	5	1	1	0	1	0	0	0.992	1.000	1.000
576	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	21	ACTA1(1), ADCY1(1), MYT1(1)	9862094	3	3	3	5	2	0	1	0	0	0	0.998	1.000	1.000
577	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(1), ADRB2(1), PLCE1(1)	7254107	3	3	3	4	2	0	1	0	0	0	0.995	1.000	1.000
578	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	CREBBP(2), NME1(1)	5223874	3	3	3	2	1	1	0	1	0	0	0.905	1.000	1.000
579	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(1), ADRB2(1)	6407639	2	2	2	4	1	0	1	0	0	0	0.999	1.000	1.000
580	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(1), PRKACA(1)	3229945	2	2	2	3	1	0	0	1	0	0	0.996	1.000	1.000
581	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(1), ALDH1B1(1)	4188083	2	2	2	2	1	0	0	1	0	0	0.955	1.000	1.000
582	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	APOBEC3B(1), APOBEC4(1)	3622104	2	2	2	2	1	1	0	0	0	0	0.964	1.000	1.000
583	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(1), LDLR(1)	2626695	2	2	2	3	0	1	1	0	0	0	0.987	1.000	1.000
584	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(2)	7231079	2	2	2	3	1	0	0	1	0	0	0.985	1.000	1.000
585	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(1), POLR2B(1)	6601566	2	2	2	2	0	0	1	1	0	0	0.971	1.000	1.000
586	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	PRKCA(1), PTPRA(1)	4530046	2	2	2	2	0	1	0	1	0	0	0.962	1.000	1.000
587	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	TGFBR1(1), TGFBR3(1)	5217566	2	2	2	3	0	1	0	1	0	0	0.987	1.000	1.000
588	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA10(1), NDUFS2(1)	3420566	2	2	2	2	0	1	0	1	0	0	0.958	1.000	1.000
589	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACAT1(1)	2668750	1	1	1	2	0	0	1	0	0	0	0.993	1.000	1.000
590	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	LSS(1)	5393125	1	1	1	2	1	0	0	0	0	0	0.987	1.000	1.000
591	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	B3GALT2(1)	3558492	1	1	1	2	0	1	0	0	0	0	0.984	1.000	1.000
592	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(1)	2092805	1	1	1	4	0	0	1	0	0	0	1.000	1.000	1.000
593	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6		2723436	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
594	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8		1955043	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
595	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4		1166609	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
596	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7		2505900	0	0	0	2	0	0	0	0	0	0	1.000	1.000	1.000
597	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7		3016626	0	0	0	3	0	0	0	0	0	0	1.000	1.000	1.000
598	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	16		5237546	0	0	0	4	0	0	0	0	0	0	1.000	1.000	1.000
599	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13		6323233	0	0	0	3	0	0	0	0	0	0	1.000	1.000	1.000
600	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8		1495957	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
601	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6		2421039	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
602	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7		2349470	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
603	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		251649	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
604	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3		1106799	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
605	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2		1038804	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
606	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4		1521609	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
607	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6		2088048	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
608	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6		3224718	0	0	0	2	0	0	0	0	0	0	1.000	1.000	1.000
609	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5		4546828	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
610	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5		1901020	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
611	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3		845788	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
612	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	5		4409340	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
613	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	11		4726424	0	0	0	2	0	0	0	0	0	0	1.000	1.000	1.000
614	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6		1586566	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
615	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3		562845	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
616	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4		1553474	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
