rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	PIK3CA(6), PIK3R1(1), PLCB1(5), PLCG1(1), PRKCA(1), VAV1(3)	4699509	17	15	16	1	2	3	1	8	3	0	0.0506	0.00995	1.000
2	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	F13A1(3), F2(3), F2R(1), FGA(2), FGB(2), FGG(2), PLG(1)	4869769	14	14	14	1	1	3	6	3	1	0	0.113	0.0117	1.000
3	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(2), JAK1(1), JAK3(2), PIAS1(3), PTPRU(8), SOAT1(1)	5161931	17	16	17	2	4	2	5	4	2	0	0.130	0.0146	1.000
4	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(1), COASY(1), DPYD(6), ENPP1(3), ENPP3(2), PANK1(2), PANK3(1), PANK4(1), PPCS(1)	5105361	18	16	18	1	0	6	4	2	6	0	0.0264	0.0178	1.000
5	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(2), TAT(2), TYR(2)	1661167	6	6	6	0	2	2	1	0	1	0	0.161	0.0182	1.000
6	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	14	ARF1(1), CCND1(1), CDK2(1), CDK4(1), CDKN1A(2), CDKN2A(2), MDM2(1)	2700879	9	9	9	1	2	1	1	2	3	0	0.178	0.0231	1.000
7	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(2), IFNG(1), JAK1(1), PTPRU(8), STAT1(2)	4202463	14	13	14	2	3	3	3	4	1	0	0.144	0.0366	1.000
8	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	DPM2(1), NTRK1(3), PIK3CA(6), PIK3R1(1), PLCG1(1), PRKCA(1), SOS1(2)	5667907	15	15	14	1	4	1	3	4	3	0	0.102	0.0398	1.000
9	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRB(2), HMOX1(1), IL10RA(2), IL1A(1), JAK1(1), STAT1(2), STAT3(1), STAT5A(1), TNF(1)	4447478	12	12	12	0	3	1	3	2	3	0	0.0252	0.0423	1.000
10	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	CISH(2), IL6R(2), JAK1(1), JAK3(2), PTPRU(8), STAT3(1)	5659860	16	15	16	2	4	2	4	6	0	0	0.123	0.0486	1.000
11	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(2), CYP2E1(3), NR1I3(1), PTGS1(1), PTGS2(1)	1930001	8	7	8	1	1	0	4	2	1	0	0.332	0.0491	1.000
12	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(1), GABRA2(2), GABRA4(1), GABRA5(2), GABRA6(2), PRKCE(2)	2932096	10	9	10	1	2	4	1	1	2	0	0.131	0.0568	1.000
13	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(2), AASDHPPT(1), AASS(1), KARS(1)	1721168	5	5	5	0	0	2	1	0	2	0	0.354	0.0696	1.000
14	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(1), ALPL(3), ALPP(1), FPGS(2), GGH(1)	2456794	8	8	8	1	1	2	4	0	1	0	0.235	0.0739	1.000
15	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAS1(1), ALAS2(3), CPOX(1), PPOX(1), UROD(1), UROS(1)	2756873	8	8	8	0	0	1	4	1	2	0	0.108	0.0850	1.000
16	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARSA(1), FARSB(2), PAH(1), TAT(2), YARS(1), YARS2(2)	3169326	9	9	9	0	0	3	3	2	1	0	0.0786	0.0894	1.000
17	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(1), ADH4(2), ADH6(1), ADH7(3)	2053931	7	6	7	1	1	1	0	1	4	0	0.568	0.0977	1.000
18	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(2), AASDH(1), AASDHPPT(1), AASS(1), KARS(1)	2522076	6	6	6	0	0	2	1	1	2	0	0.282	0.103	1.000
19	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CCL3(1), EPO(1), FLT3(2), IGF1(1), IL1A(1), KITLG(1), TGFB1(1)	3069948	8	8	8	1	1	1	5	0	1	0	0.297	0.105	1.000
20	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	BCAR1(2), MAPK1(1), NFKB1(1), PIK3C2G(7), PIK3CA(6), PIK3R1(1), PLCG1(1), PRKCA(1), PTK2(3), PTK2B(2), RELA(2)	10306290	27	26	26	3	2	5	5	8	7	0	0.0662	0.107	1.000
21	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(1), ENO2(2), ENO3(1), PAH(1), TAT(2), YARS(1)	2962340	8	8	8	0	1	2	2	1	2	0	0.133	0.109	1.000
22	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	AGT(1), AGTR1(2), AGTR2(1), COL4A1(6), COL4A2(3), COL4A3(7), COL4A4(4), COL4A5(3), COL4A6(4), REN(1)	9310142	32	24	31	3	0	12	5	6	9	0	0.0191	0.121	1.000
23	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	CBS(1), CTH(1), MUT(3)	1785709	5	5	5	1	0	2	1	2	0	0	0.471	0.123	1.000
24	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	FUT1(3), FUT2(1), FUT9(3)	2229696	7	6	7	1	3	3	0	1	0	0	0.187	0.127	1.000
25	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	21	CCNA1(1), CCND1(1), CCNH(1), CDK2(1), CDK4(1), CDKN1A(2), CDKN2A(2), CDKN2D(1), TFDP1(1)	5262647	11	11	11	1	2	2	3	2	2	0	0.146	0.141	1.000
26	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	23	APC(5), AXIN1(1), BTRC(2), CCND1(1), CREBBP(4), CTBP1(3), DVL1(2), MAP3K7(1), MYC(3), TLE1(2), WIF1(4)	10816158	28	22	28	1	10	7	2	1	8	0	0.000977	0.143	1.000
27	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	17	CDKN1A(2), NFATC2(2), NFATC3(1), PLCG1(1), PPP3CB(1), PPP3CC(2), PRKCA(1), SP1(2), SP3(2), SYT1(2)	7256637	16	16	16	1	2	2	6	3	3	0	0.111	0.143	1.000
28	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(2), BDH2(2), HMGCS2(2), OXCT2(1)	2638910	7	7	7	1	3	0	2	1	1	0	0.415	0.154	1.000
29	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR2(2), ITPKA(1), PDE1A(2), PDE1B(3), PLCB1(5), PLCB2(2), VIP(1)	4001845	16	13	16	3	4	5	1	4	2	0	0.139	0.164	1.000
30	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA2A(1), ADORA3(3), P2RY2(1), P2RY6(1)	2024181	6	6	6	0	0	1	3	2	0	0	0.162	0.166	1.000
31	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	FUT1(3), FUT2(1), FUT5(1)	1864311	5	5	5	0	2	2	1	0	0	0	0.104	0.168	1.000
32	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	CDKN1A(2), MAP2K2(1), NGFR(1), NTRK1(3), PIK3CA(6), PIK3CD(1), SOS1(2)	6145534	16	15	15	2	7	0	3	4	2	0	0.171	0.179	1.000
33	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(1), PLCB1(5), TUB(4)	2563556	10	9	10	2	2	4	1	3	0	0	0.267	0.186	1.000
34	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	15	BCAR1(2), MAPK1(1), PIK3CA(6), PIK3R1(1), PTK2(3), SOS1(2)	6774781	15	14	14	1	1	1	5	5	3	0	0.130	0.193	1.000
35	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLD1(3), POLE(5), POLG(1), POLL(1), POLQ(7)	6066222	17	14	16	0	1	5	9	1	1	0	0.00738	0.196	1.000
36	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(3), CHAT(2), PDHA2(2)	2513069	7	7	7	1	3	2	1	0	1	0	0.159	0.202	1.000
37	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	KLRC3(2), LAT(1), PAK1(1), PIK3CA(6), PIK3R1(1), PTK2B(2), RAC1(1), SYK(2), VAV1(3)	6927674	19	18	18	3	3	4	3	5	4	0	0.109	0.203	1.000
38	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(1), LPL(2), RXRA(1), TNF(1)	2089629	5	5	5	1	2	0	2	0	1	0	0.468	0.204	1.000
39	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG3(1), ATG5(1), BECN1(1), IFNA1(1), IFNA14(1), IFNA16(1), IFNA17(1), IFNA6(1), IFNA8(1), IFNG(1), PIK3R4(2), PRKAA2(5), ULK1(3), ULK2(2), ULK3(1)	7772672	23	19	23	2	2	11	6	3	1	0	0.0132	0.217	1.000
40	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(3), ENO1(1), PFKL(3), PKLR(2)	3423391	9	8	9	1	4	0	1	1	3	0	0.162	0.218	1.000
41	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	12	IGF1(1), IGF1R(2), PIK3CA(6), PIK3R1(1)	4769192	10	10	9	0	2	1	1	4	2	0	0.0646	0.220	1.000
42	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDPS(2), IDI1(1)	1210986	3	3	3	0	0	0	1	0	2	0	0.835	0.225	1.000
43	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	6	MYC(3), SP1(2), SP3(2)	2200882	7	6	7	0	1	2	1	1	2	0	0.179	0.228	1.000
44	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	CLOCK(1), CRY1(3), CRY2(1), PER1(3)	3053904	8	8	8	0	0	3	1	2	2	0	0.133	0.235	1.000
45	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(2), MTMR2(1), NFS1(1), THTPA(1), TPK1(1)	2291177	6	5	6	1	1	0	3	0	2	0	0.613	0.238	1.000
46	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	MMP2(2), MMP9(1), RECK(1), TIMP1(2), TIMP2(1)	2838598	7	7	7	0	0	1	3	2	1	0	0.175	0.241	1.000
47	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(1), CCND1(1), CDK2(1), CDK4(1), CDKN2A(2), E2F4(2)	3270479	8	7	8	0	1	1	2	2	2	0	0.111	0.254	1.000
48	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	TAT(2)	933936	2	2	2	0	0	1	0	0	1	0	0.617	0.259	1.000
49	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(2), ACO1(3), ACO2(1), ACSS2(2), IDH1(2)	4807792	10	9	10	1	1	3	1	2	3	0	0.132	0.261	1.000
50	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BAG4(1), CASP8(1), RIPK1(2), TNF(1), TNFRSF1A(1), TRADD(1), TRAF2(2)	3033151	9	9	9	2	2	3	3	0	1	0	0.394	0.264	1.000
51	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AMD1(1), CBS(1), CTH(1), DNMT1(2), DNMT3A(3), DNMT3B(2), MARS(1), MARS2(2), MTFMT(1), MTR(2), TAT(2)	7629131	18	17	18	2	1	1	6	3	6	1	0.308	0.267	1.000
52	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(1), PLCG1(1), PRKCA(1), PTK2B(2)	2380601	5	5	5	0	0	2	0	1	2	0	0.183	0.267	1.000
53	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	11	CDK2(1), CUL1(3), NEDD8(1), TFDP1(1)	2511369	6	5	6	1	2	1	0	1	2	0	0.361	0.270	1.000
54	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ARPC1B(1), PAK1(1), PDGFRA(1), PIK3CA(6), PIK3R1(1), RAC1(1)	4916517	11	10	10	0	2	1	2	4	2	0	0.0619	0.273	1.000
55	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(1), GNAS(2), PRKACA(2)	2414448	5	5	5	1	2	0	0	3	0	0	0.584	0.279	1.000
56	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	18	EIF2S2(1), IGF1(1), IGF1R(2), INPPL1(1), PIK3CA(6), PIK3R1(1), RPS6(1)	6987314	13	13	12	1	4	1	1	5	2	0	0.119	0.281	1.000
57	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	FMOD(3)	1295790	3	3	3	0	1	1	1	0	0	0	0.310	0.289	1.000
58	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	25	EGFR(3), JAK1(1), JUN(1), MAP2K4(2), PIK3CA(6), PIK3R1(1), PLCG1(1), PRKCA(1), RASA1(3), SOS1(2), SRF(1), STAT1(2), STAT3(1), STAT5A(1)	12778247	26	23	25	2	2	6	4	6	7	1	0.0188	0.305	1.000
59	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	5	SP1(2), SP3(2)	1706064	4	4	4	0	0	1	1	1	1	0	0.449	0.307	1.000
60	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(1), CD34(1), CD3G(1), CD58(1), KITLG(1)	2286355	5	5	5	1	0	2	1	0	2	0	0.612	0.310	1.000
61	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	FUT1(3), FUT2(1), FUT9(3), GLA(1)	3591708	8	7	8	0	3	3	0	1	1	0	0.0506	0.317	1.000
62	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA1(3), ANXA3(2), ANXA4(1), ANXA6(2), EDNRA(1), HSD11B1(1), PLA2G4A(1), PTGER2(2), PTGIR(1), PTGIS(1), PTGS1(1), PTGS2(1), SCGB1A1(1), TBXAS1(1)	7468312	19	15	19	2	2	6	4	3	3	1	0.0504	0.318	1.000
63	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	8	CCNA1(1), CDK2(1), CUL1(3), TFDP1(1)	2554215	6	5	6	1	2	1	1	1	1	0	0.355	0.322	1.000
64	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(1), ACAT1(2), HADHA(1)	1998983	4	4	4	0	0	0	2	2	0	0	0.418	0.335	1.000
65	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAS1(1), ALAS2(3), UROD(1), UROS(1)	3016547	6	6	6	1	0	0	3	1	2	0	0.508	0.341	1.000
66	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3G(1)	410001	1	1	1	1	0	0	1	0	0	0	0.974	0.350	1.000
67	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	FUT1(3), FUT2(1), FUT9(3), GLA(1)	3800907	8	7	8	1	3	3	0	1	1	0	0.160	0.356	1.000
68	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(2), LPL(2)	1932232	4	4	4	1	1	0	2	1	0	0	0.694	0.357	1.000
69	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDPS(2), IDI1(1)	1596756	3	3	3	0	0	0	1	0	2	0	0.839	0.365	1.000
70	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(6), COL4A2(3), COL4A3(7), COL4A4(4), COL4A5(3), COL4A6(4)	9375404	27	21	26	3	0	12	4	4	7	0	0.0395	0.365	1.000
71	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	ADCY1(1), ARHGEF1(1), F2(3), F2R(1), MAP3K7(1), PIK3CA(6), PIK3R1(1), PLCB1(5), PPP1R12B(1), PRKCA(1), PTK2B(2), ROCK1(1)	9449923	24	21	23	4	2	6	5	6	5	0	0.132	0.383	1.000
72	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	14	ABL1(2), CDKN2A(2), MDM2(1), MYC(3), PIK3CA(6), PIK3R1(1), POLR1A(1), RAC1(1), TWIST1(1)	6369223	18	15	17	4	3	2	1	5	7	0	0.394	0.383	1.000
73	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(4), FTCD(2), GART(2), MTFMT(1), MTHFD1(1), MTHFD1L(1), MTHFR(1), MTHFS(1), MTR(2)	6960957	15	13	15	2	2	1	7	2	3	0	0.301	0.384	1.000
74	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(1)	598636	1	1	1	0	0	1	0	0	0	0	0.623	0.388	1.000
75	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(4), GART(2), MTHFD1(1), MTHFD1L(1), MTHFR(1), MTHFS(1), MTR(2)	6531366	12	11	12	1	2	0	6	2	2	0	0.276	0.392	1.000
76	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	CBS(1), CTH(1), DNMT1(2), DNMT3A(3), DNMT3B(2), MARS(1), MARS2(2), MTR(2)	6442203	14	14	14	2	1	0	5	3	4	1	0.442	0.396	1.000
77	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	ADCY1(1), ITGAV(3), MAPK1(1), PDGFRA(1), PIK3CA(6), PIK3R1(1), PLCB1(5), PRKCA(1), PTK2(3), RAC1(1), SMPD2(2)	9881048	25	19	24	3	3	4	5	8	5	0	0.0586	0.398	1.000
78	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(1), CTH(1), LDHB(1), MPST(1)	2471833	4	4	4	0	0	0	1	1	2	0	0.663	0.419	1.000
79	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	34	DOCK1(3), GAB1(1), HGF(2), ITGA1(1), JUN(1), MAP2K2(1), MAP4K1(3), MAPK1(1), MET(4), PAK1(1), PIK3CA(6), PIK3R1(1), PTK2(3), PTK2B(2), PTPN11(3), RAP1A(1), RASA1(3), SOS1(2), STAT3(1)	16349474	40	35	39	5	7	8	9	8	8	0	0.0166	0.430	1.000
80	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	15	MAP2K2(1), MAP2K3(2), MAP2K6(2), MAPK1(1), NFKB1(1), PIK3CA(6), PIK3R1(1), RELA(2), SP1(2)	6541830	18	15	17	3	3	3	3	6	3	0	0.238	0.434	1.000
81	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	21	CCND1(1), CDK2(1), CDK4(1), CDKN1A(2), MAPK1(1), NFKB1(1), PAK1(1), PIK3CA(6), PIK3R1(1), RAC1(1), RELA(2), TFDP1(1)	6775184	19	17	18	4	4	4	3	5	3	0	0.262	0.434	1.000
82	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(3), GABRA1(1), GABRA2(2), GABRA4(1), GABRA5(2), GABRA6(2)	4462982	11	10	11	2	2	4	2	2	1	0	0.226	0.442	1.000
83	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	11	CSF1R(2), EGFR(3), MET(4), PDGFRA(1), PRKCA(1), SH3GLB1(1), SH3GLB2(1)	6191398	13	11	13	1	2	6	1	2	2	0	0.0481	0.444	1.000
84	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	RAB27A(1), RAB4A(1), RAB6A(1)	1539364	3	3	3	0	1	1	0	0	1	0	0.332	0.444	1.000
85	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	FUT1(3), FUT2(1)	2584592	4	4	4	0	2	2	0	0	0	0	0.162	0.458	1.000
86	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD86(1), HLA-DRB1(1), IFNG(1), IL12RB1(1), IL12RB2(3), IL18R1(1), IL2RA(1)	4608748	9	9	9	2	1	2	3	1	2	0	0.408	0.458	1.000
87	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	BCR(2), JUN(1), MAP2K4(2), MYC(3), PIK3CA(6), PIK3R1(1), SOS1(2), STAT1(2), STAT5A(1)	10277181	20	19	19	2	3	2	5	4	6	0	0.0728	0.464	1.000
88	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDOB(3)	1377982	3	3	3	1	1	0	1	0	1	0	0.721	0.466	1.000
89	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	HLA-DRB1(1)	847222	1	1	1	1	1	0	0	0	0	0	0.868	0.476	1.000
90	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	NFKB1(1), PIK3CA(6), PIK3R1(1), RELA(2)	5148906	10	10	9	2	2	2	1	3	2	0	0.421	0.487	1.000
91	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	42	BRAF(1), CAMP(1), CREBBP(4), EGR1(1), EGR2(2), FRS2(2), JUN(1), MAP1B(5), MAP2K4(2), MAP2K7(3), MAPK1(1), MAPK10(2), MAPK8IP3(3), NTRK1(3), OPN1LW(1), PIK3C2G(7), PIK3CA(6), PIK3CD(1), PIK3R1(1), PTPN11(3), TH(1)	18973204	51	43	50	6	8	12	8	11	12	0	0.00531	0.500	1.000
92	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	22	ADCY1(1), CSF2RB(2), IGF1(1), IGF1R(2), KIT(5), KITLG(1), PIK3CA(6), PIK3R1(1), PRKACG(1), PRKAR1B(1), PRKAR2B(1)	8029323	22	19	21	4	4	3	5	5	4	1	0.209	0.509	1.000
93	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNA1(1), IFNG(1), IL16(1), IL1A(1), TNF(1)	3573687	5	5	5	0	1	0	1	2	1	0	0.210	0.512	1.000
94	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	CLOCK(1), CRY1(3), CRY2(1), NPAS2(1), NR1D1(1), PER1(3), PER2(1), PER3(3)	6075426	14	11	14	1	2	5	2	2	3	0	0.0977	0.515	1.000
95	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	FYN(1), JUN(1), THBS1(3)	2637190	5	5	5	1	1	1	1	1	1	0	0.548	0.521	1.000
96	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(2)	1254305	2	2	2	0	0	0	1	1	0	0	0.629	0.523	1.000
97	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(1), CD2(1), CD33(1), IFNA1(1), IFNG(1), ITGAX(1), TLR2(3), TLR4(1), TLR9(3)	6638696	13	13	13	2	1	2	3	5	2	0	0.343	0.529	1.000
98	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(3), ACO2(1), GRHPR(1), HAO1(1), MTHFD1(1), MTHFD1L(1)	4627844	8	7	8	1	0	2	2	1	3	0	0.324	0.530	1.000
99	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	GPD2(2), SDHA(1), UQCRC1(1)	2373935	4	4	4	0	1	0	2	1	0	0	0.387	0.537	1.000
100	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(1), ADH4(2), ADH6(1), ADH7(3), ALDH1A3(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1)	4866205	12	11	12	3	1	1	3	2	5	0	0.670	0.537	1.000
101	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(3), ACO2(1), IDH1(2)	3238529	6	5	6	0	1	2	1	0	2	0	0.125	0.538	1.000
102	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(2), JUN(1), MAP2K2(1), MAP2K3(2), MAP2K4(2), MAPK1(1), PAK1(1), PLCG1(1), PRKCA(1), PTK2B(2), RAC1(1), SOS1(2), SYT1(2)	10472422	19	18	19	2	1	4	5	4	5	0	0.0856	0.540	1.000
103	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(2), MPO(4), TPO(1), TYR(2)	3558806	9	8	9	2	0	6	1	0	2	0	0.158	0.541	1.000
104	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	IFNG(1)	1089207	1	1	1	0	0	0	0	1	0	0	0.799	0.546	1.000
105	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	16	ALOX12(2), ALOX15(1), ALOX5(2), DPEP1(2), GGT1(1), PTGIS(1), PTGS1(1), PTGS2(1), TBXAS1(1)	5802809	12	12	12	2	2	2	4	2	2	0	0.263	0.551	1.000
106	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	DPM2(1), JUN(1), NGFR(1), PIK3CA(6), PIK3R1(1), PLCG1(1), SOS1(2)	6964678	13	13	12	2	2	1	3	4	3	0	0.293	0.554	1.000
107	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ELOVL2(1), FADS1(2), FADS2(1), FASN(5), HADHA(1), HSD17B12(2), SCD(1)	5536673	13	13	13	3	2	3	3	3	2	0	0.328	0.563	1.000
108	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	JUN(1), PIK3CA(6), PIK3R1(1), PLCG1(1), PRKCA(1), RASA1(3), SOS1(2), STAT1(2), STAT3(1), STAT5A(1)	10907142	19	18	18	2	2	4	3	5	5	0	0.0892	0.572	1.000
109	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QA(1), C1QB(1), C1S(1), C2(1), C3(4), C5(2), C6(6), C7(1), C8A(1), C9(4), MASP1(3), MASP2(1), MBL2(1)	7889687	27	23	27	6	3	7	5	7	5	0	0.226	0.574	1.000
110	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	CBS(1), CTH(1), GGT1(1), MARS(1), MARS2(2), SEPHS1(1)	4555259	7	7	7	0	1	0	5	1	0	0	0.180	0.575	1.000
111	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ3(1), NDUFA13(1)	1582302	2	2	2	1	0	1	1	0	0	0	0.813	0.578	1.000
112	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	JAK1(1), JUN(1), MAP2K4(2), PDGFRA(1), PIK3CA(6), PIK3R1(1), PLCG1(1), PRKCA(1), RASA1(3), SOS1(2), SRF(1), STAT1(2), STAT3(1), STAT5A(1)	12787027	24	21	23	3	2	4	4	7	6	1	0.0854	0.581	1.000
113	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	7	CDK2(1), CUL1(3), TFDP1(1)	2468879	5	4	5	2	2	1	0	1	1	0	0.630	0.582	1.000
114	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(1), AGT(1), AGTR1(2), AGTR2(1), ANPEP(1), CPA3(1), CTSG(1), ENPEP(2), LNPEP(3), MME(3), REN(1)	7614043	17	15	17	3	3	2	3	5	4	0	0.367	0.584	1.000
115	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(1), ACACB(4), FASN(5), OXSM(1)	6002411	11	11	11	2	3	0	4	3	1	0	0.307	0.597	1.000
116	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(1), CARS2(1), CTH(1), LDHB(1), MPST(1), SULT1B1(3), SULT1C2(1), SULT4A1(1)	4641251	10	9	10	2	2	1	3	2	2	0	0.486	0.604	1.000
117	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	GNS(2), GUSB(2), IDS(1), IDUA(4), LCT(5), NAGLU(1)	5364996	15	14	15	4	4	2	6	1	2	0	0.337	0.608	1.000
118	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	FABP6(1), NR1H4(1), RXRA(1)	1979850	3	3	3	1	0	0	2	0	1	0	0.783	0.614	1.000
119	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	HADHA(1), HSD17B4(1), SIRT1(1), SIRT7(1), VNN2(2)	4338533	6	6	5	1	0	2	0	2	2	0	0.374	0.618	1.000
120	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(1), JAK1(1), STAT1(2)	2992316	4	4	4	0	0	1	1	1	1	0	0.300	0.625	1.000
121	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT10(1), GALNT3(1), GALNT7(1), GALNT8(3), GALNT9(1), WBSCR17(3)	5376663	10	9	10	1	2	5	3	0	0	0	0.0815	0.637	1.000
122	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	15	MAPK1(1), PIK3CA(6), PIK3CD(1), PTK2B(2), SOS1(2)	6982723	12	11	11	2	1	1	3	3	4	0	0.473	0.637	1.000
123	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	NFKB1(1), PLCB1(5), PRKCA(1), RELA(2)	2987636	9	8	9	3	1	5	0	2	1	0	0.540	0.648	1.000
124	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(1), BCAR1(2), CTNNA1(2), CTNNA2(5), PTK2(3)	7139877	13	11	13	1	3	4	2	4	0	0	0.0661	0.652	1.000
125	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(1), COASY(1), DPYD(6), ENPP1(3), ENPP3(2), ILVBL(1), PANK1(2), PANK3(1), PANK4(1), PPCS(1)	6404936	19	17	19	4	0	6	5	2	6	0	0.216	0.655	1.000
126	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCR3(2), HLA-DRB1(1)	1111319	3	3	3	3	1	0	1	0	1	0	0.958	0.661	1.000
127	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(2), CYP2C9(2)	738505	4	4	4	2	1	1	2	0	0	0	0.835	0.668	1.000
128	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RANBP2(3), RANGAP1(2)	3116450	5	4	5	1	1	1	0	2	1	0	0.588	0.678	1.000
129	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	CREBBP(4), EP300(2), FYN(1), IL2RG(1), IL7R(1), JAK1(1), JAK3(2), LCK(1), NMI(1), PIK3CA(6), PIK3R1(1), PTK2B(2), STAT5A(1)	10181306	24	19	23	3	4	4	3	7	6	0	0.0933	0.686	1.000
130	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(4), C5(2), C6(6), C7(1), C8A(1), C9(4)	4650902	18	16	18	5	1	3	4	7	3	0	0.472	0.690	1.000
131	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	TGDS(1), UGDH(2)	1464152	3	2	3	1	0	1	0	0	2	0	0.717	0.692	1.000
132	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	DAXX(1), FAS(1), HSPB2(1), IL1A(1), TNF(1)	4033403	5	5	5	0	1	0	2	1	1	0	0.366	0.692	1.000
133	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QA(1), C1QB(1), C1S(1), C2(1), C3(4), C5(2), C6(6), C7(1), C8A(1), C9(4)	6488569	22	20	22	5	2	5	4	7	4	0	0.275	0.693	1.000
134	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CAMK2B(1), CAMK2G(1), CAMKK1(2), SYT1(2)	4266225	6	6	6	1	0	1	4	0	1	0	0.394	0.694	1.000
135	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	SULT1E1(1), SULT2A1(1), SUOX(1)	2144661	3	3	3	0	0	1	0	1	1	0	0.427	0.696	1.000
136	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(1), ACP6(1), ACPP(1), ENPP1(3), ENPP3(2), FLAD1(2), LHPP(2), MTMR2(1), TYR(2)	5486129	15	15	15	4	1	2	9	0	3	0	0.631	0.699	1.000
137	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(2), EIF2AK4(2), EIF2S2(1)	4162422	5	5	5	1	2	0	2	0	1	0	0.717	0.701	1.000
138	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(1), ABCB11(2), ABCB4(3), ABCC1(1), ABCC3(6)	5297672	13	12	13	3	2	3	4	2	2	0	0.289	0.709	1.000
139	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(2), DIAPH1(2), FYN(1), ITGA1(1), MAPK1(1), MYLK(3), PIK3CA(6), PIK3R1(1), PTK2(3), ROCK1(1), TLN1(2)	13685710	23	19	22	2	3	2	6	7	5	0	0.0837	0.712	1.000
140	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	PTK2B(2), SOS1(2)	3155763	4	4	4	0	0	1	2	0	1	0	0.302	0.721	1.000
141	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CD3G(1)	1143747	1	1	1	1	0	0	1	0	0	0	0.964	0.744	1.000
142	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(1), AGTR1(2), EGFR(3), JUN(1), MAP2K2(1), MAP2K4(2), MAPK1(1), MEF2B(2), MEF2C(1), PAK1(1), PRKCA(1), PTK2(3), PTK2B(2), RAC1(1), SOS1(2), SYT1(2)	12611197	26	21	26	3	2	6	6	3	9	0	0.0542	0.744	1.000
143	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(1), AGT(1), AGTR1(2), AGTR2(1), KNG1(1), NOS3(3), REN(1)	3588641	10	9	10	3	0	2	2	2	4	0	0.666	0.751	1.000
144	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	6	EEA1(5), EGFR(3), TF(1)	3753889	9	7	9	3	1	4	1	1	2	0	0.491	0.751	1.000
145	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAS1(1), ALAS2(3), BLVRB(2), COX10(1), CP(4), CPOX(1), EARS2(1), EPRS(2), FTMT(2), GUSB(2), HCCS(1), HMOX1(1), HMOX2(1), PPOX(1), UGT1A10(1), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT2A3(1), UGT2B11(3), UGT2B15(2), UGT2B17(2), UROD(1), UROS(1)	15245790	38	31	38	5	7	6	12	5	8	0	0.0469	0.752	1.000
146	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	AOC3(1), CES1(1)	2200691	2	2	2	1	2	0	0	0	0	0	0.733	0.766	1.000
147	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	SEC61A2(1), SRP68(1), SRPR(1)	2736801	3	3	3	1	0	0	1	2	0	0	0.812	0.770	1.000
148	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(1), IARS(1), PDHA2(2), PDHB(1)	3627089	5	5	5	0	0	2	1	1	1	0	0.259	0.772	1.000
149	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	26	APC(5), AXIN1(1), CCND1(1), DVL1(2), LBP(1), NFKB1(1), PIK3CA(6), PIK3R1(1), RELA(2), TIRAP(1), TLR4(1), TOLLIP(1)	11032897	23	19	22	3	6	4	4	3	6	0	0.0730	0.774	1.000
150	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	CREBBP(4), SET(2)	3823208	6	5	6	1	1	2	1	0	2	0	0.467	0.777	1.000
151	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(1), CPT1A(1), PRKAA2(5), PRKAB2(1)	5263662	8	6	8	1	0	4	3	1	0	0	0.266	0.788	1.000
152	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A2(1)	1386912	1	1	1	0	0	0	0	1	0	0	0.795	0.790	1.000
153	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	TGDS(1), UGDH(2), UGP2(2)	1834327	5	4	5	2	0	2	1	0	2	0	0.778	0.793	1.000
154	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(2)	1753642	2	2	2	0	0	2	0	0	0	0	0.406	0.793	1.000
155	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ARPC1B(1), NCKAP1(2), NTRK1(3), RAC1(1), WASF3(2)	5628375	9	8	9	1	5	2	0	0	2	0	0.211	0.799	1.000
156	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A2(1), ALDH1A3(2), ALDH2(1), ALDH9A1(1)	2876523	5	5	5	2	0	0	2	2	1	0	0.820	0.801	1.000
157	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A2(1), ALDH1A3(2), ALDH2(1), ALDH9A1(1)	2876523	5	5	5	2	0	0	2	2	1	0	0.820	0.801	1.000
158	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	PRKCA(1), TGM2(1)	1852092	2	2	2	1	1	0	0	0	1	0	0.844	0.801	1.000
159	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	HADHA(1), HSD17B4(1), MECR(1)	3138623	3	3	3	0	0	1	0	1	1	0	0.426	0.808	1.000
160	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMB3(1), PSMB6(1), PSMB9(2)	3182905	4	4	4	1	0	1	3	0	0	0	0.732	0.808	1.000
161	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QA(1), C1QB(1), C1S(1), C2(1), C3(4), C5(2), C6(6), C7(1), C8A(1), C8B(1), C9(4), MASP1(3)	7667917	26	22	26	7	3	7	4	7	5	0	0.349	0.809	1.000
162	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	IL6R(2), JAK1(1), JAK3(2), JUN(1), PTPN11(3), SOS1(2), SRF(1), STAT3(1)	8838201	13	12	13	2	2	1	4	4	1	1	0.328	0.809	1.000
163	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CAMK2B(1), CAMK2G(1), ESRRA(1), HDAC5(3), MEF2B(2), MEF2C(1), PPARA(1), PPP3CB(1), PPP3CC(2), SLC2A4(1), SYT1(2)	7610070	16	14	16	3	2	4	5	0	5	0	0.215	0.811	1.000
164	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(2), HADHA(1)	2870393	3	3	3	0	0	0	1	2	0	0	0.495	0.813	1.000
165	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	ANGPTL2(2), GCA(1), ITGA9(1), ITPKA(1), ITPR1(4), ITPR2(6), ITPR3(2), MAPK1(1), NR1I3(1), PAK1(1), PDE3A(1), PDE3B(5), PI3(1), PIK3C2G(7), PIK3CA(6), PIK3CD(1), PIK3R1(1), VASP(1)	17873338	43	36	42	7	7	4	9	14	9	0	0.0942	0.819	1.000
166	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	CASP8(1)	1338569	1	1	1	1	0	0	1	0	0	0	0.949	0.819	1.000
167	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	CANX(1), CIITA(3), HLA-B(1), HLA-DOA(1), HLA-DOB(1), HLA-DQA2(3), HLA-DRB1(1), HLA-DRB5(1), HLA-E(1), HLA-F(1), HSP90AA1(2), HSP90AB1(4), IFNA1(1), IFNA14(1), IFNA16(1), IFNA17(1), IFNA6(1), IFNA8(1), KIR3DL1(2), KIR3DL2(1), KLRC3(2), LGMN(1)	17044552	32	28	32	4	5	8	9	8	2	0	0.0147	0.822	1.000
168	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(3), ACO2(1), GRHPR(1), HAO1(1), MTHFD1(1), MTHFD1L(1)	4863843	8	7	8	2	0	2	2	1	3	0	0.520	0.832	1.000
169	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	NRF1(1), UBE2C(1), UBE2G2(1), UBE2I(1), UBE2J1(1), UBE3A(1)	3910345	6	6	6	2	0	2	2	1	1	0	0.773	0.834	1.000
170	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	CDK5R1(1), DPM2(1), EGR1(1), MAP2K2(1), MAPK1(1), NGFR(1)	3099921	6	6	6	2	2	1	1	1	1	0	0.626	0.837	1.000
171	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	MBTPS1(1), SCAP(4), SREBF1(3), SREBF2(1)	4425899	9	8	9	2	2	2	3	1	1	0	0.366	0.837	1.000
172	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAT1(2), HADHA(1)	3073951	3	3	3	0	0	0	1	2	0	0	0.475	0.837	1.000
173	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD9(2), ADH1A(1), ADH4(2), ADH6(1), ADH7(3), DHRS2(1), DHRSX(1), ESCO2(1), PNPLA3(1), SH3GLB1(1)	8730530	14	11	14	2	1	4	2	1	6	0	0.318	0.845	1.000
174	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ADH1A(1), ADH4(2), ADH6(1), ADH7(3), AKR1C4(1), AKR1D1(2), ALDH1A2(1), ALDH1A3(2), ALDH2(1), ALDH9A1(1), BAAT(1), CEL(5), CYP27A1(1), SOAT2(2)	8499580	24	19	24	5	2	4	5	7	6	0	0.327	0.846	1.000
175	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT1(2), ACOT11(2), DHRS2(1), DHRSX(1), ESCO2(1), FN3K(1), HADHA(1), PNPLA3(1), SH3GLB1(1), YOD1(1)	9134287	12	12	12	1	2	3	3	3	1	0	0.107	0.848	1.000
176	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS2(2), CARS(1), CARS2(1), DARS(1), EARS2(1), EPRS(2), FARSA(1), FARSB(2), HARS2(1), IARS(1), IARS2(1), KARS(1), MARS(1), MARS2(2), MTFMT(1), QARS(1), RARS(2), SARS(2), TARS(3), TARS2(2), VARS(1), VARS2(1), WARS(1), WARS2(1), YARS(1), YARS2(2)	19648037	36	32	36	4	3	5	16	9	3	0	0.0339	0.849	1.000
177	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(1), JUNB(1), MAP2K3(2), NFATC2(2), PRKACG(1), PRKAR1B(1), PRKAR2B(1)	4388345	9	9	9	3	0	0	6	1	2	0	0.776	0.850	1.000
178	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), UGDH(2)	3110071	7	6	7	3	0	1	3	1	2	0	0.832	0.854	1.000
179	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	33	APC(5), BRAF(1), CAMP(1), CCL15(1), CCL16(1), EGFR(3), GNA11(1), ITPKA(1), ITPR1(4), ITPR2(6), ITPR3(2), KCNJ3(1), KCNJ5(2), KCNJ9(1), MAPK1(1), MAPK10(2), PHKA2(2), PIK3CA(6), PIK3CD(1), PIK3R1(1)	18937112	43	33	42	6	9	11	3	8	12	0	0.0107	0.856	1.000
180	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	JUN(1), PLCG1(1), PRKCA(1), PTK2B(2), SYT1(2)	4975119	7	7	7	2	0	2	1	1	3	0	0.652	0.859	1.000
181	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(1), ALDH18A1(1), ARG2(2), ASL(1), CKMT2(1), PYCR1(2)	6560140	8	8	8	0	2	2	2	0	2	0	0.0749	0.859	1.000
182	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(1), ACPP(1), ENPP1(3), ENPP3(2), FLAD1(2), TYR(2)	3570527	11	11	11	4	0	2	6	0	3	0	0.790	0.859	1.000
183	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	KHK(1), LCT(5), PGM1(1), PYGM(3), TREH(1)	5014463	11	10	11	3	1	4	4	1	1	0	0.399	0.860	1.000
184	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	FOSB(1)	1368893	1	1	1	0	0	0	0	0	1	0	1.000	0.865	1.000
185	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(1), FCGR3A(2), IL6R(2), SELL(1), SPN(1), TGFB1(1), TNF(1), TNFRSF1A(1), TNFRSF8(1)	5071779	11	11	11	3	3	2	2	4	0	0	0.407	0.867	1.000
186	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	DAXX(1), HSPB2(1), MAP2K4(2), MAP2K6(2), MAP3K5(4), MAP3K7(1), MAP3K9(2), MEF2B(2), MEF2C(1), MKNK1(1), MYC(3), PLA2G4A(1), RAC1(1), RIPK1(2), STAT1(2), TGFB1(1), TGFBR1(1), TRADD(1), TRAF2(2)	13690804	31	23	31	3	4	10	6	6	5	0	0.0104	0.871	1.000
187	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	EPX(2), MPO(4), MTHFR(1), TPO(1)	4216368	8	7	8	2	0	5	1	0	2	0	0.202	0.871	1.000
188	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP5O(1), ATP6AP1(2), ATP6V0A4(1), ATP6V1A(2), ATP6V1E1(1), FDXR(2)	5843705	9	7	9	2	2	0	4	2	1	0	0.515	0.872	1.000
189	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(2), GBA(1), MPO(4), TPO(1)	3086376	8	7	8	3	0	5	0	1	2	0	0.346	0.872	1.000
190	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	25	CASP2(1), JUN(1), MAP2K3(2), MAP2K4(2), MAP2K6(2), NFKB1(1), RELA(2), RIPK1(2), TNF(1), TNFRSF1A(1), TRADD(1), TRAF2(2)	8950956	18	18	18	4	3	5	2	4	4	0	0.278	0.874	1.000
191	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	JUN(1), MAPK1(1), NFE2L2(1), PRKCA(1)	3455556	4	4	4	3	0	0	0	1	3	0	0.990	0.875	1.000
192	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCR3(2), HLA-DRB1(1), IL5RA(2)	1934572	5	5	5	3	1	0	1	2	1	0	0.888	0.879	1.000
193	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(1), B4GALT5(2), FUT8(1), MAN1A1(3), MAN1B1(1), MGAT3(1), MGAT5(2), RPN2(2)	7176641	13	9	13	1	2	6	2	1	2	0	0.0327	0.884	1.000
194	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	13	EGFR(3), IGF1R(2), MYC(3), PRKCA(1), TEP1(3), TERF1(3), TERT(1)	9275999	16	15	16	3	4	3	2	1	6	0	0.315	0.885	1.000
195	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	B3GNT2(2), FUT1(3), FUT2(1), FUT5(1), FUT9(3)	5729208	10	9	10	2	3	5	1	1	0	0	0.194	0.886	1.000
196	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	20	EIF4A2(2), EIF4G1(1), EIF4G3(4), MKNK1(1), PIK3CA(6), PIK3R1(1), RPS6(1), TSC1(1), TSC2(4)	9878722	21	19	20	4	3	3	3	7	5	0	0.303	0.888	1.000
197	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT2(2), CHST1(2), CHST4(1), FUT8(1)	4349203	6	5	6	1	0	4	2	0	0	0	0.206	0.893	1.000
198	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(5), CAMP(1), CERK(1), EPHB2(1), ITPKA(1), JUN(1), MAP2K4(2), MAP2K7(3), MAPK1(1), MAPK10(2), MAPK8IP3(3)	10213555	21	18	21	4	6	6	1	2	6	0	0.109	0.894	1.000
199	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	CAMP(1), ITPKA(1)	2091289	2	2	2	0	1	1	0	0	0	0	0.405	0.895	1.000
200	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	HADHA(1)	1772393	1	1	1	0	0	0	0	1	0	0	0.778	0.897	1.000
201	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	INPP1(2), INPP4A(2), INPP4B(1), INPP5A(1), INPPL1(1), ITPKA(1), OCRL(1), PIK3C2G(7), PIK3CA(6), PIK3CB(1), PIK3CG(2), PLCB1(5), PLCB2(2), PLCB3(2), PLCB4(3), PLCG1(1), PLCG2(2)	16513155	40	35	39	8	7	9	6	12	6	0	0.118	0.899	1.000
202	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GGT1(1)	1615231	1	1	1	0	0	0	1	0	0	0	0.786	0.899	1.000
203	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	CARS(1), DARS(1), EPRS(2), IARS(1), KARS(1), MARS(1), MARS2(2), QARS(1), RARS(2), SARS(2), TARS(3), WARS(1), WARS2(1), YARS(1)	11528094	20	18	20	3	2	3	7	7	1	0	0.176	0.900	1.000
204	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(1), GNAS(2), PRKACG(1), PRKAR1B(1), PRKAR2B(1), PRKCA(1)	3575137	7	7	7	3	1	0	2	1	3	0	0.905	0.902	1.000
205	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	ST3GAL5(1)	1962197	1	1	1	1	0	0	0	1	0	0	0.935	0.902	1.000
206	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS2(1)	1609349	1	1	1	0	0	0	1	0	0	0	0.842	0.904	1.000
207	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(1), ATP6AP1(2), ATP6V0A4(1), ATP6V1A(2), ATP6V1E1(1)	5515575	7	6	7	2	1	0	4	1	1	0	0.670	0.909	1.000
208	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(1), ATP6AP1(2), ATP6V0A4(1), ATP6V1A(2), ATP6V1E1(1)	5515575	7	6	7	2	1	0	4	1	1	0	0.670	0.909	1.000
209	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(1), ATP6AP1(2), ATP6V0A4(1), ATP6V1A(2), ATP6V1E1(1)	5515575	7	6	7	2	1	0	4	1	1	0	0.670	0.909	1.000
210	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ERBB4(4), NRG2(1), NRG3(1), PRKCA(1)	3340313	7	6	7	5	2	1	1	1	2	0	0.979	0.909	1.000
211	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	IFNAR1(1), NFKB1(1), RELA(2), TRAF6(2)	4032617	6	6	6	2	1	2	2	1	0	0	0.658	0.914	1.000
212	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	NFKB1(1), NOX1(2), RELA(2), TNF(1)	3653156	6	6	6	2	2	3	1	0	0	0	0.535	0.914	1.000
213	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	APC(5), AXIN1(1), BTRC(2), DVL1(2), NOTCH1(3)	7971545	13	10	13	2	5	3	1	0	3	1	0.121	0.916	1.000
214	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNH(1), CDC25B(1), XPO1(3)	3178232	5	5	4	3	0	2	0	1	2	0	0.935	0.918	1.000
215	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	MAP2K2(1), MAP2K3(2), MAP2K6(2), MAPK1(1), NFATC2(2), NFATC3(1), NFKB1(1), PAK1(1), PIK3C2G(7), PLCB1(5), PPP3CB(1), PPP3CC(2), RAC1(1), RELA(2), SYT1(2)	14201839	31	27	31	6	3	8	9	7	4	0	0.161	0.921	1.000
216	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	CALCR(3), CALCRL(1), CD97(1), CRHR2(4), ELTD1(3), EMR1(4), EMR2(2), GLP1R(2), GLP2R(2), GPR64(1), LPHN1(1), LPHN2(4), LPHN3(2), SCTR(3), VIPR1(3)	10058928	36	27	36	9	4	7	9	11	5	0	0.206	0.923	1.000
217	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	ANXA1(3), GNAS(2), NFKB1(1), NOS3(3), PIK3CA(6), PIK3R1(1), RELA(2), SYT1(2)	6663089	20	20	19	5	4	4	3	5	3	1	0.408	0.923	1.000
218	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	BFAR(2), BRAF(1), CAMP(1), MAPK1(1)	4243969	5	4	5	1	0	3	0	1	1	0	0.475	0.924	1.000
219	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	4	EGFR(3), ERBB3(1)	2827563	4	4	4	2	0	2	1	0	1	0	0.786	0.925	1.000
220	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMB3(1), PSMB6(1), PSMC3(1), RPN2(2), UBE3A(1)	4842915	6	6	6	0	0	3	1	1	1	0	0.182	0.926	1.000
221	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	APOBEC3B(2), APOBEC3F(1), APOBEC3G(1)	2672657	4	2	4	2	0	1	1	0	2	0	0.642	0.927	1.000
222	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(1)	1763427	1	1	1	1	0	0	1	0	0	0	0.916	0.927	1.000
223	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	CNR1(3), DNMT1(2), MTNR1A(1), PTAFR(1), PTGER2(2), PTGIR(1)	4070273	10	8	10	3	2	0	3	2	3	0	0.632	0.929	1.000
224	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A2(1), ALDH1A3(2), ALDH2(1), ALDH9A1(1), HADHA(1)	4405452	6	6	6	2	0	0	2	3	1	0	0.762	0.931	1.000
225	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(2), MAP2(3), PRKACG(1), PRKAR2B(1), PRKCE(2)	6309788	9	8	9	4	0	3	1	0	4	1	0.898	0.932	1.000
226	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLD1(3), POLE(5), POLE2(1), POLE4(1), POLG(1), POLG2(1), POLL(1), POLM(1), POLQ(7), PRIM2(1), REV1(1), REV3L(3)	15074892	26	20	25	3	1	6	13	1	5	0	0.157	0.933	1.000
227	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	11	CREBBP(4), DAXX(1), PML(1), RARA(1), SIRT1(1), TNF(1), TNFRSF1A(1)	5863989	10	8	10	2	4	1	1	1	3	0	0.376	0.935	1.000
228	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ALDH1A3(2), AOC3(1), DDC(2), EPX(2), HPD(1), MAOB(1), MPO(4), TAT(2), TPO(1)	8150056	16	14	16	4	4	7	2	0	3	0	0.135	0.938	1.000
229	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	CARM1(1), DHRS2(1), DHRSX(1), HEMK1(1), PRMT2(2), PRMT3(1), PRMT6(1), PRMT8(1), WBSCR22(1)	5418274	10	8	10	3	1	4	1	2	2	0	0.648	0.938	1.000
230	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	IFNG(1), JUN(1), MAP3K5(4), MAP4K5(1), NFKB1(1), RELA(2), TNFRSF9(2), TRAF2(2)	7239520	14	13	14	4	2	4	1	3	4	0	0.525	0.939	1.000
231	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	EPX(2), MPO(4), TPO(1)	4355125	7	6	7	2	0	5	0	0	2	0	0.249	0.939	1.000
232	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	IGF1R(2), IRS1(1), MAPK1(1), PIK3CA(6), PIK3R1(1), SOS1(2)	6863214	13	12	12	4	2	0	4	4	3	0	0.683	0.940	1.000
233	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1R(2), E2F4(2), ETS1(1), ETV3(2), HDAC5(3), JUN(1), NCOR2(5), SIN3A(1)	9961986	17	15	16	3	3	5	4	3	2	0	0.155	0.940	1.000
234	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	CHST11(1), SULT1A1(1), SULT1E1(1), SULT2A1(1), SUOX(1)	3361833	5	5	5	2	1	1	0	2	1	0	0.794	0.942	1.000
235	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	ASRGL1(1), GBA(1), GGT1(1)	2122305	3	3	3	2	0	1	1	1	0	0	0.837	0.943	1.000
236	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	BLVRB(2), CP(4), CPOX(1), EPRS(2), GUSB(2), HCCS(1), HMOX1(1), HMOX2(1), PPOX(1), UGT1A10(1), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT2B15(2), UROD(1), UROS(1)	9890171	24	21	24	5	5	4	6	2	7	0	0.322	0.944	1.000
237	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(1), AKR1D1(2), CYP11B1(3), CYP11B2(1), CYP21A2(1), HSD11B1(1), HSD3B1(1), HSD3B2(1)	3614520	11	9	11	9	2	1	2	3	3	0	0.984	0.949	1.000
238	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(1), AKR1D1(2), CYP11B1(3), CYP11B2(1), CYP21A2(1), HSD11B1(1), HSD3B1(1), HSD3B2(1)	3614520	11	9	11	9	2	1	2	3	3	0	0.984	0.949	1.000
239	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(1), NME2(1), POLD1(3), POLG(1)	4779840	6	6	5	2	0	2	4	0	0	0	0.669	0.949	1.000
240	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTN1(1), CAPN1(1), CAPNS1(1), ITGA1(1), PTK2(3), RAC1(1), SPTAN1(4), TLN1(2)	10456609	14	11	14	1	3	1	2	2	6	0	0.260	0.949	1.000
241	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(2), PARK2(1), SNCAIP(1), UBE2G2(1)	2297950	5	5	5	3	1	2	1	0	1	0	0.880	0.950	1.000
242	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(3), ACO2(1), IDH1(2), IDH3A(1), IDH3B(1), IDH3G(1), PC(1), SDHA(1)	7512166	11	9	11	2	2	3	4	0	2	0	0.219	0.951	1.000
243	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD3G(1), IFNG(1), IL2RA(1), TGFB1(1), TGFBR1(1), TGFBR2(1), TGFBR3(2)	3791044	8	8	8	3	0	1	4	2	1	0	0.804	0.951	1.000
244	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(2), ME1(1), PC(1)	3411882	4	4	4	2	1	1	1	1	0	0	0.775	0.952	1.000
245	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5R1(1), DAB1(3), FYN(1), LRP8(3), RELN(6)	5035368	14	12	14	6	2	3	2	3	4	0	0.744	0.953	1.000
246	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	HDAC9(1), MEF2B(2), MEF2C(1)	3118191	4	3	4	2	1	1	0	0	2	0	0.853	0.954	1.000
247	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARF1(1), ARFGEF2(2), GBF1(4), GPLD1(1)	5863824	8	7	8	2	2	2	3	0	1	0	0.445	0.955	1.000
248	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMB3(1), PSMB6(1), PSMC2(2), PSMC3(1), PSMD1(1)	5837056	6	5	6	0	0	2	2	1	1	0	0.200	0.955	1.000
249	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	GNS(2), GUSB(2), HPSE2(3), IDS(1), IDUA(4), LCT(5), NAGLU(1), SPAM1(2)	7683431	20	18	20	5	6	3	7	1	3	0	0.249	0.956	1.000
250	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(1), FSHR(1), GNAS(2), XPO1(3)	3459802	7	7	6	3	2	0	1	2	2	0	0.887	0.956	1.000
251	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSE(1), GAL3ST1(1), GALC(3), GBA(1), GLA(1), LCT(5), NEU3(2), PPAP2A(1), PPAP2B(2), PPAP2C(1), SMPD2(2), SPTLC1(1)	8779606	21	16	20	9	2	2	4	2	10	1	0.911	0.956	1.000
252	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	IFNG(1), IL1A(1), NR4A3(1), WDR1(1)	3950518	4	4	4	2	1	0	2	1	0	0	0.814	0.957	1.000
253	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	6	ATM(5), ATR(4), CHEK2(2)	5437621	11	8	11	3	0	3	2	3	3	0	0.644	0.957	1.000
254	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA4(1), NDUFB6(1)	2605610	2	2	2	2	0	0	1	0	1	0	0.960	0.957	1.000
255	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(2), HK2(2), IMPA2(1), PGM1(1), TGDS(1)	4334350	7	6	7	2	2	1	3	0	1	0	0.474	0.960	1.000
256	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CDC25B(1), PRKCA(1), PTPRA(2)	3396251	4	4	4	5	0	2	0	0	2	0	0.990	0.960	1.000
257	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	33	GTF2A1L(1), GTF2B(1), GTF2H1(1), STON1(2), TAF1(4), TAF10(1), TAF1L(9), TAF2(1), TAF6(1), TAF6L(3), TAF7L(2), TBPL1(1), TBPL2(1)	13167323	28	19	28	4	7	5	7	3	6	0	0.0739	0.961	1.000
258	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(1), HEMK1(1), PRMT2(2), PRMT3(1), PRMT6(1), PRMT8(1), WBSCR22(1)	5147800	8	6	8	3	1	3	0	2	2	0	0.804	0.961	1.000
259	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(1), SDHA(1)	3434441	2	2	2	0	0	0	1	0	1	0	0.665	0.961	1.000
260	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	CD3G(1), FYN(1), JUN(1), LAT(1), LCK(1), MAP2K4(2), NFATC2(2), NFATC3(1), NFKB1(1), PIK3CA(6), PIK3R1(1), PLCG1(1), PPP3CB(1), PPP3CC(2), PRKCA(1), PTPN7(2), RAC1(1), RASA1(3), RELA(2), SOS1(2), SYT1(2), VAV1(3), ZAP70(5)	17363398	43	35	42	8	6	12	9	9	7	0	0.0675	0.961	1.000
261	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(2), JUN(1), MAPK1(1), MYC(3), NFKB1(1), PLCB1(5), PRKCA(1), RELA(2), TNF(1)	5596474	17	13	17	6	3	7	1	2	4	0	0.522	0.962	1.000
262	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(2), ARHGEF1(1), MYLK(3), PLCB1(5), PPP1R12B(1), PRKCA(1), ROCK1(1)	7585600	14	9	14	3	1	4	2	5	2	0	0.354	0.963	1.000
263	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	MST1R(2), TNF(1)	2385049	3	3	3	2	2	0	0	1	0	0	0.864	0.963	1.000
264	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25B(1), CDKN1A(2), NEK1(2), WEE1(1)	2805220	6	5	6	3	2	1	1	1	1	0	0.851	0.964	1.000
265	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(1), GAD1(1), GAD2(2), GGT1(1)	2135444	5	4	5	3	0	1	2	2	0	0	0.848	0.964	1.000
266	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(3), CAPN2(1), CAPNS1(1), EP300(2), NFATC2(2), PPP3CB(1), PPP3CC(2), PRKCA(1), SYT1(2)	8714492	15	15	15	4	1	1	6	3	4	0	0.725	0.965	1.000
267	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAD9(2), ADH1A(1), ADH4(2), ADH6(1), ADH7(3), AKR1B10(1), AKR1C4(1), AKR1D1(2), ALDH1A3(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), BAAT(1), CEL(5), CYP27A1(1), LIPA(1), SLC27A5(1), SOAT1(1), SOAT2(2)	11745500	30	24	30	7	3	6	7	6	8	0	0.316	0.966	1.000
268	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(2), HK2(2), PGM1(1), TGDS(1)	3777947	6	5	6	2	2	1	2	0	1	0	0.554	0.967	1.000
269	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(1), ACSL3(1), ACSL4(2), CPT1A(1), HADHA(1), SLC25A20(1)	6097115	7	7	7	2	1	1	2	3	0	0	0.613	0.970	1.000
270	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	EPO(1)	2279173	1	1	1	0	0	0	1	0	0	0	0.803	0.970	1.000
271	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	GUSB(2), UCHL3(1), UGDH(2), UGT1A10(1), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT2B15(2)	6343518	12	12	12	6	4	2	0	1	5	0	0.884	0.970	1.000
272	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	EIF2B3(1), EIF2S2(1), FLT1(3), FLT4(2), HIF1A(1), KDR(4), NOS3(3), PIK3CA(6), PIK3R1(1), PLCG1(1), PRKCA(1), PTK2(3)	12545933	27	26	26	6	3	3	6	10	5	0	0.349	0.970	1.000
273	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ASL(1)	2814992	1	1	1	0	0	0	1	0	0	0	0.840	0.971	1.000
274	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	23	CAPN1(1), CAPN2(1), CAPNS1(1), EGFR(3), ITGA1(1), MAPK1(1), MYLK(3), PRKACG(1), PRKAR1B(1), PRKAR2B(1), PTK2(3), TLN1(2)	11179443	19	17	19	4	3	2	7	1	6	0	0.437	0.971	1.000
275	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS2(1), DHRSX(1), ESCO2(1), PNPLA3(1), SH3GLB1(1)	5628602	5	5	5	1	0	2	2	0	1	0	0.512	0.971	1.000
276	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(1), ACACA(1), ACADL(1), ACADSB(1), ACAT1(2), ALDH1A2(1), ALDH1A3(2), ALDH2(1), ALDH9A1(1), HADHA(1), LDHB(1), MUT(3)	11998306	16	16	16	3	0	2	5	6	3	0	0.409	0.972	1.000
277	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	23	ABL1(2), ATM(5), ATR(4), CCNA1(1), CCND1(1), CDK2(1), CDK4(1), CDKN1A(2), CDKN2A(2), TFDP1(1), TGFB1(1)	10005747	21	18	21	5	3	2	5	5	6	0	0.433	0.972	1.000
278	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR2(2), GPR34(1), GPR45(1)	3379606	4	3	4	2	0	1	0	1	2	0	0.738	0.972	1.000
279	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(1), ACACA(1), ACACB(4), ACAT1(2), ACSS2(2), ALDH1A3(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), HADHA(1), LDHB(1), MUT(3)	14371111	20	20	20	4	2	2	6	6	4	0	0.336	0.972	1.000
280	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	22	IL1A(1), MAP3K7(1), NFKB1(1), RELA(2), RIPK1(2), TLR4(1), TNF(1), TNFRSF1A(1), TRADD(1), TRAF6(2)	8910922	13	13	13	3	3	5	4	1	0	0	0.336	0.973	1.000
281	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	GCK(2), GNE(3), HK2(2)	6237256	7	7	7	2	2	0	4	1	0	0	0.715	0.973	1.000
282	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(5), AXIN1(1), CREBBP(4), DVL1(2), EP300(2), LDB1(1), TRRAP(3)	11792033	18	15	18	3	5	3	1	3	6	0	0.171	0.974	1.000
283	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	FURIN(1), NOTCH1(3)	3694734	4	4	4	2	1	0	1	0	1	1	0.881	0.974	1.000
284	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	14	ATM(5), CCND1(1), CDK2(1), CDK4(1), CDKN1A(2), MDM2(1)	5666772	11	10	11	4	2	2	3	3	1	0	0.692	0.975	1.000
285	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	IGF1(1), IGF1R(2), IRS1(1), JUN(1), PIK3CA(6), PIK3R1(1), PTPN11(3), RASA1(3), SOS1(2), SRF(1)	9042555	21	18	20	5	3	5	4	5	3	1	0.336	0.975	1.000
286	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	30	CABIN1(3), HDAC5(3), IGF1(1), IGF1R(2), MAP2K6(2), MAPK7(1), MEF2B(2), MEF2C(1), NFATC2(2), PIK3CA(6), PIK3R1(1), PPP3CB(1), PPP3CC(2), SYT1(2)	12734094	29	25	28	5	4	4	8	7	6	0	0.114	0.975	1.000
287	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AP2A1(2), AP2M1(2), ARF1(1), BTK(1), EEA1(5), LYN(1), PFKL(3), PFKP(2), PLCG1(1), PRKCE(2), RAC1(1), VAV2(3)	9322719	24	17	24	7	3	8	3	2	8	0	0.186	0.975	1.000
288	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(4), EP300(2), LPL(2), NCOA1(4), RXRA(1)	6565269	13	11	13	4	2	2	4	3	2	0	0.735	0.975	1.000
289	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	9	EGFR(3), NCOR2(5), RARA(1), RXRA(1), THRA(1)	5555701	11	10	11	4	3	4	1	1	2	0	0.532	0.977	1.000
290	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	BTK(1), FCER1A(1), JUN(1), LYN(1), MAP2K4(2), MAP2K7(3), MAPK1(1), NFATC2(2), NFATC3(1), PIK3CA(6), PIK3R1(1), PLA2G4A(1), PLCG1(1), PPP3CB(1), PPP3CC(2), SOS1(2), SYK(2), SYT1(2), VAV1(3)	15537290	34	29	33	7	5	5	8	8	8	0	0.199	0.977	1.000
291	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(2), SOS1(2), STAT5A(1)	6559041	5	5	5	1	1	0	4	0	0	0	0.566	0.977	1.000
292	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	F13B(1), HSD17B1(1), HSD17B2(1), HSD17B4(1), HSD3B1(1), HSD3B2(1)	2901571	6	6	6	5	1	0	1	3	1	0	0.969	0.979	1.000
293	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(4), EP300(2), MAPK1(1)	5243300	7	6	7	3	1	1	0	2	3	0	0.894	0.980	1.000
294	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(2), CYP11B2(1), HSD11B1(1), HSD3B1(1), HSD3B2(1)	2489502	6	5	6	7	1	2	1	1	1	0	0.977	0.981	1.000
295	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ARPC1B(1), RAC1(1)	2993320	2	2	2	0	1	1	0	0	0	0	0.449	0.981	1.000
296	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(2), CARM1(1), CCND1(1), CREBBP(4), EP300(2), GRIP1(3), HDAC3(1), HDAC4(1), HDAC5(3), HDAC6(2), MEF2C(1), NCOR2(5), NR0B1(2), NRIP1(3)	17109588	31	27	31	5	5	6	7	6	7	0	0.118	0.983	1.000
297	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	15	AGT(1), AGTR2(1), EDNRA(1), EGFR(3), JUN(1), MYC(3), NFKB1(1), PLCG1(1), PRKCA(1), RELA(2)	6436121	15	13	15	5	2	6	0	2	5	0	0.592	0.983	1.000
298	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(2), CYP2A13(1), NAT1(1)	2956209	4	4	4	3	1	1	0	1	1	0	0.889	0.983	1.000
299	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(1), FDPS(2), IDI1(1)	4108902	4	4	4	2	0	0	2	0	2	0	0.933	0.984	1.000
300	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	EPHA4(2), EPHB1(2), FYN(1), ITGA1(1), L1CAM(1), LYN(1), SELP(2)	5665133	10	9	10	4	2	3	1	3	1	0	0.660	0.986	1.000
301	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDK2(1), DIAPH2(4), MCM10(3), MCM3(3), MCM4(1), MCM5(1), MCM7(2), NACA(2), POLD1(3), POLE(5), POLE2(1), RPA1(1), RPA4(1), UBB(2)	18294290	30	24	29	4	3	9	10	2	6	0	0.0400	0.986	1.000
302	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	NFKB1(1), PIK3CA(6), PIK3R1(1), RAC1(1), RALGDS(1), RELA(2)	7227662	12	12	11	4	2	3	1	4	2	0	0.550	0.987	1.000
303	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(1), GNAS(2), PRKAA2(5), PRKAB2(1), PRKACG(1), PRKAR1B(1), PRKAR2B(1)	5628747	12	10	12	4	2	4	4	1	1	0	0.594	0.987	1.000
304	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	33	DUSP1(1), MAP2K4(2), MAP2K7(3), MAPK1(1), MAPK10(2), MAPK11(1), MAPK8IP3(3), NFKB1(1), NFKBIL1(1), PIK3CA(6), PIK3CD(1), PIK3R1(1), SYT1(2), TRAF2(2), TRAF6(2)	12720638	29	24	28	7	4	7	6	6	6	0	0.227	0.987	1.000
305	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	ARHGAP5(2), CASP8(1), JUN(1)	4610117	4	4	4	2	0	0	1	2	1	0	0.905	0.988	1.000
306	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(2), IL22RA1(1), JAK1(1), JAK3(2), STAT1(2), STAT3(1), STAT5A(1), TYK2(1)	6946608	11	10	11	4	2	2	2	3	2	0	0.583	0.988	1.000
307	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	DPM2(1), EGFR(3), GNAS(2), IGF1R(2), MAP2K2(1), MAPK1(1), MKNK1(1), MYC(3), NGFR(1), PDGFRA(1), PTPRR(2), RPS6KA1(1), SOS1(2), STAT3(1)	12362648	22	16	22	4	6	5	4	4	3	0	0.129	0.988	1.000
308	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	CARM1(1), CBS(1), CTH(1), GGT1(1), HEMK1(1), MARS(1), MARS2(2), PRMT2(2), PRMT3(1), PRMT6(1), PRMT8(1), SEPHS1(1), WBSCR22(1)	9203641	15	13	15	4	2	3	5	3	2	0	0.556	0.989	1.000
309	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	CASP8(1), SCAP(4), SREBF1(3), SREBF2(1)	6657577	9	8	9	3	1	2	4	1	1	0	0.636	0.989	1.000
310	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ADH1A(1), ADH4(2), ADH6(1), ADH7(3), ALDH1A3(2), AOC3(1), AOX1(2), DBH(1), DCT(3), DDC(2), HPD(1), MAOB(1), TAT(2), TH(1), TPO(1), TYR(2)	11695787	26	20	26	6	5	9	5	2	5	0	0.193	0.990	1.000
311	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(1), LDHB(1)	3314487	2	2	2	3	1	0	0	0	1	0	0.993	0.990	1.000
312	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOB(3), FBP1(1), GPT2(2), ME1(1), ME3(2), PGK2(1), PKLR(2), TKT(1), TKTL1(2), TKTL2(1)	7178839	16	15	16	9	5	0	4	2	5	0	0.900	0.990	1.000
313	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	HLA-DRB1(1), IFNA1(1), IFNG(1), IL1A(1), TGFB1(1), TNF(1)	4930052	6	6	6	3	2	0	2	2	0	0	0.747	0.991	1.000
314	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	CHIT1(1), GNE(3), HK2(2), LHPP(2), MTMR2(1)	10557998	9	8	9	1	2	0	5	1	1	0	0.350	0.991	1.000
315	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(1), GNAS(2), PLCE1(6), PRKACG(1), PRKAR1B(1), PRKAR2B(1)	5352106	12	12	12	6	3	2	3	1	3	0	0.830	0.991	1.000
316	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	AKR1B10(1), DHRS2(1), DHRSX(1)	3218589	3	3	3	2	0	1	2	0	0	0	0.819	0.991	1.000
317	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	CES1(1)	4111526	1	1	1	1	1	0	0	0	0	0	0.904	0.992	1.000
318	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(5), CDH1(1), CREBBP(4), EP300(2), MAP3K7(1), SKIL(2), TGFB1(1), TGFBR1(1), TGFBR2(1)	9099210	18	16	18	5	2	3	5	2	6	0	0.633	0.992	1.000
319	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD3G(1), CD86(1), CTLA4(1), HLA-DRB1(1), ITK(1), LCK(1), PIK3CA(6), PIK3R1(1), PTPN11(3)	4617731	16	14	15	5	3	4	3	4	2	0	0.515	0.992	1.000
320	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	31	ANPEP(1), GCLC(1), GGT1(1), GPX5(2), GSTA4(1), GSTM5(1), IDH1(2), MGST1(1)	6773898	10	9	10	3	2	2	3	0	3	0	0.631	0.992	1.000
321	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	42	DAXX(1), EGFR(3), ETS1(1), JUN(1), MAP2K3(2), MAP2K4(2), MAP2K6(2), MAP2K7(3), MAP3K5(4), MAPK1(1), NFKB1(1), PRKCA(1), PRKCE(2), PRKCG(1), PRKCH(1), PRKCQ(3), RELA(2), RIPK1(2), SP1(2), TNF(1), TNFRSF1A(1), TRAF2(2)	16958508	39	30	39	9	5	14	6	5	9	0	0.112	0.993	1.000
322	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	CHRNG(2), MUSK(1), PIK3CA(6), PIK3R1(1), PTK2(3), PTK2B(2), TERT(1)	6111194	16	13	15	5	2	2	3	4	5	0	0.475	0.993	1.000
323	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(2), ENPP1(3), ENPP3(2), NMNAT1(1), NT5E(1)	5288067	9	9	9	4	1	3	3	0	2	0	0.781	0.993	1.000
324	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	CAPN1(1), CAPNS1(1), CDK5R1(1), MAPT(1)	3509081	4	4	4	3	1	0	2	0	1	0	0.962	0.993	1.000
325	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP1(1), ACP6(1), ACPP(1), ALPI(1), ALPL(3), ALPP(1), CYP3A4(3), CYP3A7(2), DHRS2(1), DHRSX(1)	6549669	15	14	15	5	1	4	6	2	2	0	0.537	0.993	1.000
326	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CD3G(1), ETV5(2), IFNG(1), IL12RB1(1), IL12RB2(3), IL18R1(1), JUN(1), MAP2K6(2), STAT4(1), TYK2(1)	6914576	14	13	14	8	0	3	2	5	4	0	0.933	0.993	1.000
327	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	CASP8(1), MAP2K4(2), MAPK1(1), NFKB1(1), NSMAF(1), RELA(2), RIPK1(2), TNFRSF1A(1), TRADD(1), TRAF2(2)	7379044	14	14	14	5	2	5	2	1	4	0	0.580	0.993	1.000
328	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	DHCR7(1), FDPS(2), IDI1(1)	4898722	4	4	4	2	0	0	2	0	2	0	0.941	0.994	1.000
329	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOB(3), FBP1(1), GPT2(2), ME1(1), ME3(2), PKLR(2), TKT(1)	6453560	12	12	12	7	5	0	2	1	4	0	0.851	0.994	1.000
330	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(1), CD3G(1), ITGAL(2), ITGB2(1), PTPRC(4)	3834888	9	9	9	5	2	1	4	1	1	0	0.887	0.994	1.000
331	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(1), IARS(1), IARS2(1), ILVBL(1), PDHA2(2), PDHB(1), VARS(1), VARS2(1)	6745540	9	9	9	3	0	2	4	1	2	0	0.706	0.994	1.000
332	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B4GALT5(2), FUT8(1)	2817160	3	1	3	0	1	2	0	0	0	0	0.238	0.994	1.000
333	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOB(3), DLAT(1), ENO1(1), ENO2(2), ENO3(1), FBP1(1), GAPDH(1), GCK(2), HK2(2), LDHB(1), PC(1), PDHA2(2), PDHB(1), PDHX(1), PFKL(3), PFKP(2), PGK2(1), PKLR(2), TNFAIP1(1)	15474983	29	25	29	5	7	3	9	4	6	0	0.107	0.994	1.000
334	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	16	CREBBP(4), EP300(2), HDAC3(1), NFKB1(1), RELA(2), RIPK1(2), TNF(1), TNFRSF1A(1), TRADD(1), TRAF6(2)	8073375	17	14	17	5	4	6	1	4	2	0	0.490	0.995	1.000
335	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(2), BST1(2), ENPP1(3), ENPP3(2), NADK(1), NMNAT1(1), NT5E(1), NUDT12(1)	7861894	13	12	13	5	2	3	3	1	3	1	0.689	0.995	1.000
336	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(3), F2R(1), ITGA1(1), MAPK1(1), PLA2G4A(1), PLCB1(5), PRKCA(1), PTGS1(1), PTK2(3), SYK(2), TBXAS1(1)	8893130	20	16	20	6	1	5	7	3	4	0	0.559	0.995	1.000
337	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	JUN(1), PRKACG(1), PRKAR1B(1), PRKAR2B(1)	4610753	4	4	4	7	0	0	2	0	2	0	1.000	0.995	1.000
338	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(2), AASDH(1), AASDHPPT(1), AASS(1), ACAT1(2), ALDH1A2(1), ALDH1A3(2), ALDH2(1), ALDH9A1(1), BBOX1(2), DOT1L(1), EHMT1(1), EHMT2(1), HADHA(1), PLOD2(2), PLOD3(1), TMLHE(1)	13493942	22	22	22	5	1	2	6	8	5	0	0.442	0.995	1.000
339	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(1), PRKACG(1), PRKAR2B(1)	3595388	3	3	3	2	0	0	1	1	1	0	0.953	0.995	1.000
340	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(1), CREBBP(4), EP300(2), PRKACG(1), PRKAR1B(1), PRKAR2B(1), RARA(1), RXRA(1)	7395853	12	11	12	5	2	1	3	2	4	0	0.898	0.995	1.000
341	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(1), CD3G(1), ITGAL(2), ITGB2(1), PTPRC(4)	4037825	9	9	9	5	2	1	4	1	1	0	0.888	0.995	1.000
342	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	ACVR1(2), APC(5), AXIN1(1), BMP5(1), BMPR2(1), CHRD(2), DVL1(2), GATA4(1), MAP3K7(1), MEF2C(1), NKX2-5(1), TGFB1(1), TGFBR1(1), TGFBR2(1), TGFBR3(2)	13106925	23	18	23	5	3	4	5	3	8	0	0.347	0.995	1.000
343	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCL3(1), CCR1(2), CCR3(2), CCR4(1), IFNG(1), IL12RB1(1), IL12RB2(3), IL18R1(1), TGFB1(1)	7298089	13	13	13	5	1	3	4	1	4	0	0.577	0.995	1.000
344	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	ASNS(1), CA12(1), CA2(3), CA3(1), CA4(1), CA9(1), CTH(1), GLS2(1), GLUL(2)	6889549	12	12	12	4	4	2	5	0	1	0	0.582	0.996	1.000
345	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	SNAP29(1), STX16(2), STX7(1), TSNARE1(1), VAMP7(1), YKT6(2)	6240000	8	5	8	2	2	2	2	0	1	1	0.472	0.996	1.000
346	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(1), ACAT1(2), ALDH1A2(1), ALDH1A3(2), ALDH2(1), ALDH9A1(1), DLAT(1), GRHPR(1), LDHB(1), ME1(1), ME3(2), PC(1), PDHA2(2), PDHB(1), PKLR(2)	13440618	20	17	20	4	2	3	7	4	4	0	0.278	0.996	1.000
347	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT6(2), ENPP2(2), PAFAH1B3(1), PAFAH2(2), PLA2G12B(1), PLA2G2D(1), PLA2G4A(1), PLD1(3), PLD2(1), PPAP2A(1), PPAP2B(2), PPAP2C(1)	8656591	18	15	18	7	5	3	3	1	5	1	0.791	0.996	1.000
348	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	ITGAL(2), ITGAM(2), ITGB2(1), SELL(1)	3940335	6	6	6	5	1	1	1	2	1	0	0.931	0.996	1.000
349	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CD2(1), CD3G(1), IFNG(1), IL12RB1(1), IL12RB2(3), STAT4(1), TYK2(1)	5458648	9	9	9	6	0	3	2	2	2	0	0.954	0.996	1.000
350	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	19	ATM(5), PRKCA(1), PTK2(3), STAT1(2), TLN1(2)	9662396	13	12	13	4	1	2	4	2	4	0	0.696	0.996	1.000
351	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNA1(1), IFNAR1(1), JAK1(1), STAT1(2), STAT2(1), TYK2(1)	4029460	7	7	7	6	0	1	3	2	1	0	0.968	0.996	1.000
352	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	NFKB1(1), RELA(2), TRAF2(2), TRAF6(2)	5356275	7	7	7	3	1	2	2	1	1	0	0.804	0.996	1.000
353	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCR3(2), GNAS(2), LIMK1(3), MAPK1(1), NOX1(2), PIK3C2G(7), PLCB1(5), PPP1R12B(1), PRKCA(1), PTK2(3), ROCK2(2)	9331349	29	24	29	9	1	7	9	7	5	0	0.624	0.997	1.000
354	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	MAPK1(1), MAPK7(1), MEF2B(2), MEF2C(1), NTRK1(3), PIK3CA(6), PIK3R1(1), PLCG1(1), RPS6KA1(1)	7168538	17	13	16	5	5	3	1	4	4	0	0.401	0.997	1.000
355	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	GLI2(1), GLI3(1), PRKACG(1), PRKAR1B(1), PRKAR2B(1), SUFU(2)	5994491	7	7	7	3	0	1	2	1	3	0	0.808	0.997	1.000
356	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	EGR2(2), MYC(3), NFATC2(2), NFKB1(1), PLCG1(1), PPP3CB(1), PPP3CC(2), PRKACG(1), PRKAR1B(1), PRKAR2B(1), RELA(2), SYT1(2), VIP(1)	9914991	20	18	20	5	3	4	6	3	4	0	0.485	0.998	1.000
357	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	AZIN1(1), CLOCK(1), CRY1(3), CRY2(1), ETV6(1), G0S2(1), HSPA8(1), IDI1(1), MYF6(1), NCKAP1(2), NCOA4(1), NR1D2(1), PER1(3), PER2(1), SF3A3(1), SUMO3(2), UGP2(2), ZFR(1)	13274049	25	24	25	6	1	8	3	4	9	0	0.528	0.998	1.000
358	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(1), DLAT(1), IDH3A(1), IDH3B(1), IDH3G(1), PC(1), PDHA2(2), PDHB(1), PDHX(1), SDHA(1)	10384001	11	10	11	2	1	4	4	1	1	0	0.253	0.998	1.000
359	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	ALDOB(3), FBP1(1), FPGT(2), GCK(2), GMDS(1), GMPPA(2), HK2(2), KHK(1), PFKFB1(1), PFKFB4(3), PFKP(2)	8801420	20	18	20	6	9	1	5	0	5	0	0.427	0.998	1.000
360	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(1), JAK3(2), MAPK1(1), STAT3(1), TYK2(1)	4446433	6	6	6	4	1	0	1	3	1	0	0.951	0.998	1.000
361	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AP2A1(2), AP2M1(2), DNM1(3), NME2(1), PICALM(1), PPP3CB(1), PPP3CC(2), SYNJ1(2), SYNJ2(1), SYT1(2)	8346889	17	14	17	5	2	5	6	1	3	0	0.464	0.998	1.000
362	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(5), CDC25B(1), MYT1(3), WEE1(1)	4991626	10	9	10	7	0	4	4	1	1	0	0.968	0.998	1.000
363	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3G(1), FYN(1), HLA-DRB1(1), LCK(1), PTPRC(4), ZAP70(5)	3322111	13	11	13	5	4	5	3	1	0	0	0.503	0.998	1.000
364	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	20	ATM(5), ATR(4), BRCA1(2), BRCA2(5), CHEK2(2), FANCC(2), RAD17(1), RAD50(2)	15366085	23	19	23	7	1	6	3	5	7	1	0.748	0.998	1.000
365	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	RPL11(1), RPL13A(1), RPL14(2), RPL36A(2), RPL41(1), RPL7(1), RPS20(1), RPS23(1), RPS26(1), RPS6(1), RPS7(1)	8540258	13	13	12	4	5	1	3	1	3	0	0.770	0.998	1.000
366	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	27	BAG4(1), CASP2(1), CASP8(1), JUN(1), LMNB1(1), MADD(2), MAP2K4(2), MAP3K7(1), PAK1(1), PRKDC(6), RIPK1(2), SPTAN1(4), TNF(1), TNFRSF1A(1), TRADD(1), TRAF2(2)	13924165	28	24	28	6	4	6	6	1	11	0	0.330	0.999	1.000
367	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ASPH(3), EP300(2), EPO(1), HIF1A(1), JUN(1), NOS3(3)	6235979	11	11	11	8	0	2	3	4	2	0	0.980	0.999	1.000
368	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	52	AGT(1), CREBBP(4), ELSPBP1(2), F2(3), GATA4(1), IGF1(1), MAPK1(1), MEF2C(1), MYH2(6), NFATC2(2), NFATC3(1), NKX2-5(1), PIK3CA(6), PIK3R1(1), PPP3CB(1), PPP3CC(2), PRKACG(1), PRKAR1B(1), PRKAR2B(1), SYT1(2)	18251535	39	32	38	9	4	5	13	5	12	0	0.462	0.999	1.000
369	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(1), DHCR7(1), FDPS(2), GGCX(2), IDI1(1), TM7SF2(1)	7089469	8	8	8	3	1	1	2	1	3	0	0.691	0.999	1.000
370	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(6), COL4A2(3), COL4A3(7), COL4A4(4), COL4A5(3), COL4A6(4), F11(3), F12(1), F2(3), F2R(1), F5(6), F8(4), FGA(2), FGB(2), FGG(2), KLKB1(2), PROS1(1)	16167349	54	38	53	13	2	21	11	9	11	0	0.235	0.999	1.000
371	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	IL2RA(1), IL2RB(5), IL2RG(1), JAK1(1), JAK3(2), JUN(1), LCK(1), SOS1(2), STAT5A(1), SYK(2)	8785940	17	16	17	5	4	3	6	2	2	0	0.374	0.999	1.000
372	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	IFNA1(1), IL1A(1), IL1RN(1), IRAK2(2), IRAK3(2), JUN(1), MAP2K3(2), MAP2K6(2), MAP3K7(1), NFKB1(1), RELA(2), TGFB1(1), TNF(1), TOLLIP(1), TRAF6(2)	10934083	21	20	21	6	3	2	7	7	2	0	0.578	0.999	1.000
373	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F2(3), F2R(1), F5(6), F7(1), FGA(2), FGB(2), FGG(2), PROS1(1), TFPI(1)	5974371	19	18	19	8	1	6	6	4	2	0	0.769	0.999	1.000
374	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(2), ACO1(3), ACO2(1), CLYBL(1), IDH1(2), IDH3A(1), IDH3B(1), IDH3G(1), OGDHL(4), PC(1), SDHA(1)	10840787	18	16	18	5	2	7	4	1	4	0	0.246	0.999	1.000
375	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(1), JAK1(1), PTPRU(8), STAT1(2), STAT2(1), TYK2(1)	4631421	14	14	14	8	3	2	4	4	1	0	0.873	0.999	1.000
376	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	BAIAP2(3), CASP8(1), GAPDH(1), MAGI1(3), MAGI2(3), RERE(2), WWP1(2), WWP2(1)	8458608	16	14	16	5	1	4	3	5	3	0	0.527	0.999	1.000
377	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CREBBP(4), DUSP1(1), EP300(2), MAP2K3(2), MAP2K6(2), MAP3K7(1), MAPK11(1), NFKB1(1), RELA(2), TGFBR1(1), TGFBR2(1), TLR2(3), TNF(1)	10641363	22	19	22	6	4	4	4	7	3	0	0.518	0.999	1.000
378	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	10	ATM(5), CDC25B(1), CDK2(1), CDK4(1), MYT1(3), WEE1(1)	5443228	12	11	12	7	0	5	5	1	1	0	0.930	0.999	1.000
379	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	21	EIF4A2(2), EIF4G1(1), EIF4G3(4), IRS1(1), MAPK1(1), MKNK1(1), PABPC1(2), PIK3CA(6), PIK3R1(1), PRKCA(1)	9944861	20	17	19	5	1	5	4	5	5	0	0.482	0.999	1.000
380	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	92	ACTB(3), CABIN1(3), CAMK2B(1), CD3G(1), CDKN1A(2), CNR1(3), CREBBP(4), CTLA4(1), EGR2(2), EP300(2), FCER1A(1), FCGR3A(2), GATA3(1), GATA4(1), IFNA1(1), IFNG(1), IL2RA(1), ITK(1), JUNB(1), MAP2K7(3), MEF2B(2), MYF5(1), NCK2(1), NFAT5(4), NFATC2(2), NFATC3(1), P2RX7(1), PAK1(1), PIN1(1), PPP3CB(1), PPP3CC(2), PTPRC(4), RELA(2), RPL13A(1), SLA(2), SP1(2), SP3(2), TGFB1(1), TNF(1), TRAF2(2), TRPV6(2), VAV1(3), VAV2(3), VAV3(1), XPO5(1)	33285245	79	57	79	13	12	15	23	14	15	0	0.0169	0.999	1.000
381	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(1), ADH4(2), ADH6(1), ADH7(3), ALDH1A2(1), ALDH1A3(2), ALDH2(1), ALDH9A1(1), CEL(5), DGAT1(1), DGKB(1), DGKD(3), DGKE(1), DGKG(3), DGKH(2), DGKQ(1), DGKZ(1), GLA(1), LCT(5), LIPC(3), LIPF(1), LPL(2), PNLIPRP1(1), PPAP2A(1), PPAP2B(2), PPAP2C(1)	17882073	47	35	46	10	4	9	15	8	10	1	0.199	0.999	1.000
382	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	LCT(5), MAN2C1(1), NEU3(2)	6002669	8	6	8	5	1	1	3	0	2	1	0.856	0.999	1.000
383	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	34	IL2RA(1), IL2RB(5), IL2RG(1), IRS1(1), JAK1(1), JAK3(2), MAPK1(1), MYC(3), NMI(1), PIK3CA(6), PIK3R1(1), SOS1(2), STAT5A(1), SYK(2)	13392191	28	23	27	7	6	3	8	5	6	0	0.341	0.999	1.000
384	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ALDH1A3(2), AOC3(1), DDC(2), EPX(2), ESCO2(1), HPD(1), MAOB(1), MPO(4), PNPLA3(1), SH3GLB1(1), TAT(2), TPO(1)	12263102	19	15	19	5	4	8	3	0	4	0	0.184	0.999	1.000
385	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(2), ALDH1A3(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), CYP2C19(2), CYP2C9(2), DHRS2(1), DHRSX(1), ESCO2(1), HADHA(1), PNPLA3(1), SH3GLB1(1), YOD1(1)	10906688	18	17	18	5	2	4	7	3	2	0	0.480	0.999	1.000
386	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	IRS1(1), JUN(1), PIK3CA(6), PIK3R1(1), PTPN11(3), RASA1(3), SLC2A4(1), SOS1(2), SRF(1)	9275979	19	17	18	6	2	5	4	4	3	1	0.539	0.999	1.000
387	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(3), ATP4B(1), ATP5O(1), ATP6AP1(2), ATP6V0A4(1), ATP6V1A(2), ATP6V1E1(1), ATP7A(1), ATP7B(3), COX10(1), COX6A2(1), COX7C(1), NDUFA4(1), NDUFB6(1), SDHA(1), UQCRB(1), UQCRC1(1)	13899298	23	21	23	6	2	3	12	2	4	0	0.437	0.999	1.000
388	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	18	ABL1(2), ATM(5), BRCA1(2), CDKN1A(2), CHEK2(2), JUN(1), MDM2(1), NFKB1(1), RAD50(2), RBBP8(2), RELA(2)	10350783	22	19	22	8	3	8	3	4	4	0	0.718	1.000	1.000
389	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(1), CFTR(7), GNAS(2), PRKACG(1), PRKAR1B(1), PRKAR2B(1)	4788042	13	12	13	6	3	1	3	5	1	0	0.828	1.000	1.000
390	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CR1(3), CR2(2), FCGR2B(1), HLA-DRB1(1), ITGAL(2), ITGB2(1), PTPRC(4)	5552076	14	12	14	7	3	5	4	1	1	0	0.743	1.000	1.000
391	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	ADCY1(1), CAMK2B(1), CAMK2G(1), GNAS(2), MAPK1(1), PIK3CA(6), PIK3R1(1), PRKACG(1), PRKAR1B(1), PRKAR2B(1), PRKCA(1), RAC1(1), RPS6KA1(1), SOS1(2)	10664146	21	20	20	6	3	2	6	4	6	0	0.573	1.000	1.000
392	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ADCY1(1), GNAS(2), MAPK1(1), MYT1(3), PIN1(1), PRKACG(1), PRKAR1B(1), PRKAR2B(1), RPS6KA1(1)	7483966	12	10	12	7	2	3	3	1	3	0	0.897	1.000	1.000
393	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	32	BTK(1), CDKN2A(2), IARS(1), INPP5D(3), PIK3CA(6), PPP1R13B(1), RPS6KA1(1), SOS1(2), TEC(2), YWHAE(2), YWHAQ(1)	12755817	22	21	20	9	3	5	3	5	6	0	0.855	1.000	1.000
394	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(1), ABCC2(3), CES1(1), CYP3A4(3), UGT1A10(1), UGT1A4(1), UGT1A5(2), UGT1A6(1)	8230653	13	13	13	9	4	2	2	2	3	0	0.959	1.000	1.000
395	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLRMT(1)	4965190	1	1	1	3	0	0	0	0	1	0	1.000	1.000	1.000
396	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	32	JUN(1), MAP2K3(2), MAP2K4(2), MAP2K6(2), MAP3K7(1), NFKB1(1), PPARA(1), RELA(2), TIRAP(1), TLR2(3), TLR3(2), TLR4(1), TLR9(3), TOLLIP(1), TRAF6(2)	13328791	25	22	25	7	2	4	6	9	4	0	0.477	1.000	1.000
397	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	17	EGFR(3), MAPK1(1), PTPRB(4), RASA1(3), SOS1(2), SPRY1(1), SPRY3(2)	8240669	16	13	16	5	1	7	4	1	3	0	0.454	1.000	1.000
398	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	ABAT(1), ADSL(1), AGXT(1), AGXT2(1), ASL(1), ASNS(1), ASPA(1), CAD(4), DARS(1), GAD1(1), GAD2(2), GPT2(2), PC(1)	9520031	18	16	18	7	2	4	5	3	4	0	0.702	1.000	1.000
399	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOB(3), DERA(1), FBP1(1), H6PD(2), PFKL(3), PFKP(2), PGM1(1), TKT(1), TKTL1(2), TKTL2(1)	8874984	17	13	17	9	4	2	5	1	5	0	0.843	1.000	1.000
400	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(2), ANAPC2(3), ANAPC4(2), ANAPC5(1), BTRC(2), CDC20(1), CUL1(3), CUL3(1), FZR1(2), SMURF2(1), UBA1(1), UBE2C(1), WWP1(2), WWP2(1)	14898061	23	19	23	5	5	4	3	9	2	0	0.232	1.000	1.000
401	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	ITGA4(2), ITGAL(2), ITGAM(2), ITGB2(1), SELL(1), SELP(2)	5959207	10	10	10	7	2	1	3	3	1	0	0.934	1.000	1.000
402	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	GUSB(2), UGDH(2), UGP2(2), UGT1A10(1), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT2A3(1), UGT2B11(3), UGT2B15(2), UGT2B17(2)	9825650	19	17	19	7	5	5	3	2	4	0	0.687	1.000	1.000
403	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(2), ACTB(3), ARHGEF2(2), ARPC5(1), CDH1(1), CLDN1(2), CTTN(3), EZR(1), FYN(1), HCLS1(3), KRT18(1), NCK2(1), OCLN(1), PRKCA(1), ROCK1(1), ROCK2(2), TLR4(1), TLR5(2), TUBA3C(3), TUBA3D(1), TUBA3E(1), TUBA4A(1), TUBA8(1), TUBAL3(2), TUBB2B(2), TUBB8(3), YWHAQ(1)	19185241	44	35	43	10	5	8	11	9	11	0	0.224	1.000	1.000
404	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(2), ACTB(3), ARHGEF2(2), ARPC5(1), CDH1(1), CLDN1(2), CTTN(3), EZR(1), FYN(1), HCLS1(3), KRT18(1), NCK2(1), OCLN(1), PRKCA(1), ROCK1(1), ROCK2(2), TLR4(1), TLR5(2), TUBA3C(3), TUBA3D(1), TUBA3E(1), TUBA4A(1), TUBA8(1), TUBAL3(2), TUBB2B(2), TUBB8(3), YWHAQ(1)	19185241	44	35	43	10	5	8	11	9	11	0	0.224	1.000	1.000
405	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	16	IFNG(1), LIN7A(1), NFKB1(1), RELA(2), TNF(1), TNFRSF1A(1), USH1C(2)	5790312	9	9	9	4	4	3	1	1	0	0	0.659	1.000	1.000
406	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(1), ACACB(4), ACAT1(2), ACSS2(2), ALDH1A3(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), DLAT(1), GRHPR(1), LDHB(1), ME1(1), ME3(2), PC(1), PDHA2(2), PDHB(1), PKLR(2)	16943621	26	23	26	6	4	3	9	5	5	0	0.274	1.000	1.000
407	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(1), ALDH1A3(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), AOC3(1), DPYD(6), GAD1(1), GAD2(2), HADHA(1)	9778521	17	13	17	7	1	5	3	4	4	0	0.658	1.000	1.000
408	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	37	ANPEP(1), GCLC(1), GGT1(1), GPX5(2), GSTA4(1), GSTM5(1), IDH1(2), MGST1(1)	8255982	10	9	10	6	2	2	3	0	3	0	0.926	1.000	1.000
409	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(1), CD3G(1), CREBBP(4), GNAS(2), HLA-DRB1(1), LCK(1), PRKACG(1), PRKAR1B(1), PRKAR2B(1), PTPRC(4), ZAP70(5)	8368487	22	20	22	8	7	5	5	2	3	0	0.598	1.000	1.000
410	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(1), CD3G(1), CREBBP(4), GNAS(2), HLA-DRB1(1), LCK(1), PRKACG(1), PRKAR1B(1), PRKAR2B(1), PTPRC(4), ZAP70(5)	8368487	22	20	22	8	7	5	5	2	3	0	0.598	1.000	1.000
411	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(1), DLG4(1), EPHB2(1), F2(3), F2RL2(1), JUN(1), MAP2K5(1), MAPK1(1), MAPK7(1), PLD1(3), PLD2(1), PTK2(3), RASAL1(1), TEC(2), VAV1(3)	10110544	24	21	24	8	6	3	7	4	4	0	0.649	1.000	1.000
412	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2B(1), CAMK2G(1), ITPKA(1), ITPR1(4), ITPR2(6), ITPR3(2), NFAT5(4), PDE6A(1), PDE6B(3), PDE6C(1), PDE6H(1), SLC6A13(1), TF(1)	13084564	27	23	27	7	9	4	4	3	7	0	0.232	1.000	1.000
413	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	ACHE(3), CHAT(2), DBH(1), DDC(2), GAD1(1), GAD2(2), HDC(3), PAH(1), TH(1)	5322099	16	14	16	9	7	5	0	3	1	0	0.731	1.000	1.000
414	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(1), ALPL(3), ALPP(1), ASCC3(2), ATP13A2(1), DDX18(2), DDX23(2), DDX4(1), DDX41(1), DDX50(1), DDX51(1), DDX52(1), DDX56(1), EP400(3), FPGS(2), GGH(1), IFIH1(1), MOV10L1(1), QDPR(2), RAD54B(1), RAD54L(1), RUVBL2(2), SETX(3), SMARCA2(2), SMARCA5(2)	23094349	39	32	39	9	6	10	12	4	7	0	0.168	1.000	1.000
415	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B4GALNT1(4), LCT(5), ST3GAL5(1), ST6GALNAC3(1), ST6GALNAC5(1), ST6GALNAC6(1)	5843211	13	11	13	7	3	1	6	2	1	0	0.900	1.000	1.000
416	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ARHGAP5(2), ARHGAP6(1), ARHGEF1(1), ARHGEF11(2), ARHGEF5(1), ARPC1B(1), BAIAP2(3), DIAPH1(2), LIMK1(3), MYLK(3), OPHN1(1), PIP5K1A(1), PIP5K1B(1), PPP1R12B(1), ROCK1(1), TLN1(2)	16840224	26	20	26	5	6	4	7	5	4	0	0.215	1.000	1.000
417	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5R1(1), DRD1(1), DRD2(1), GRM1(1), PLCB1(5), PRKACG(1), PRKAR1B(1), PRKAR2B(1)	5703949	12	9	12	5	1	4	3	3	1	0	0.698	1.000	1.000
418	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	ANKHD1(1), EEF1G(2), EEF2(1), EIF2AK3(2), EIF2B3(1), EIF2S2(1), EIF4A2(2), EIF4G1(1), EIF4G3(4), EIF5B(1), GSPT2(1), PABPC1(2), PABPC3(3), PAIP1(1), SLC35A4(1)	16257785	24	20	24	5	3	8	2	6	5	0	0.236	1.000	1.000
419	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	25	IRS1(1), MAPK1(1), PIK3CA(6), PIK3R1(1), PLCG1(1), PRKCA(1), RPS6KA1(1), SLC2A4(1), SOS1(2), SRF(1), STAT5A(1)	12039323	17	16	16	6	2	2	4	4	4	1	0.725	1.000	1.000
420	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	16	B3GAT1(2), CHPF(1), CHST11(1), CHST14(1), CHST3(1), DSE(2), XYLT1(1), XYLT2(2)	5189556	11	8	11	5	2	6	0	2	1	0	0.532	1.000	1.000
421	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(1), ADH4(2), ADH6(1), ADH7(3), ALDH1A2(1), ALDH1A3(2), ALDH2(1), ALDH9A1(1), ALDOB(3), DLAT(1), ENO1(1), ENO2(2), ENO3(1), FBP1(1), GAPDH(1), GCK(2), HK2(2), LDHB(1), PDHA2(2), PDHB(1), PFKP(2), PGM1(1), PKLR(2)	17865584	35	26	35	9	7	5	9	5	9	0	0.369	1.000	1.000
422	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(1), ADH4(2), ADH6(1), ADH7(3), ALDH1A2(1), ALDH1A3(2), ALDH2(1), ALDH9A1(1), ALDOB(3), DLAT(1), ENO1(1), ENO2(2), ENO3(1), FBP1(1), GAPDH(1), GCK(2), HK2(2), LDHB(1), PDHA2(2), PDHB(1), PFKP(2), PGM1(1), PKLR(2)	17865584	35	26	35	9	7	5	9	5	9	0	0.369	1.000	1.000
423	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	CAD(4), DPYD(6), DTYMK(1), ENTPD1(1), NME2(1), NT5E(1), POLD1(3), POLE(5), POLG(1), POLL(1), POLQ(7), POLRMT(1), RRM2(1), TXNRD1(4), UMPS(1)	21093456	38	27	37	7	2	10	14	5	7	0	0.108	1.000	1.000
424	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(1), GPLD1(1), PGAP1(2), PIGB(1), PIGC(2), PIGG(2), PIGN(3), PIGS(2), PIGT(1)	9057052	15	13	15	5	1	7	2	3	2	0	0.438	1.000	1.000
425	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACADL(1), ACADSB(1), ACAT1(2), ALDH1A2(1), ALDH1A3(2), ALDH2(1), ALDH9A1(1), AOX1(2), BCAT1(1), BCKDHA(1), HADHA(1), MCCC1(1), MUT(3)	13123762	18	16	18	5	0	4	4	7	3	0	0.527	1.000	1.000
426	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	LCT(5), MAN2B2(1), MAN2C1(1), NEU3(2)	7408902	9	7	9	5	2	1	3	0	2	1	0.777	1.000	1.000
427	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AOC3(1), CES1(1), ESCO2(1), LIPA(1), PLA1A(2), PNPLA3(1), SH3GLB1(1)	8956790	8	7	8	3	3	3	1	0	1	0	0.535	1.000	1.000
428	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(1), ACADL(1), ACADSB(1), ALDH1A2(1), ALDH1A3(2), ALDH2(1), ALDH9A1(1), AOC3(1), DPYD(6), GAD1(1), GAD2(2), HADHA(1)	10508406	19	15	19	7	1	5	3	6	4	0	0.589	1.000	1.000
429	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	63	ATM(5), ATR(4), BAI1(4), CASP8(1), CCNB3(1), CCND1(1), CCNG1(1), CDK2(1), CDK4(1), CDKN1A(2), CDKN2A(2), CHEK2(2), DDB2(1), EI24(1), FAS(1), GTSE1(1), IGF1(1), MDM2(1), RRM2(1), THBS1(3), TNFRSF10B(1), TSC2(4), ZMAT3(1)	23404902	41	33	41	8	6	6	9	11	9	0	0.145	1.000	1.000
430	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	18	ABCB1(1), ATM(5), CDKN1A(2), HIC1(1), HIF1A(1), MDM2(1)	7243173	11	10	11	9	1	2	4	3	1	0	0.989	1.000	1.000
431	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(1), AGTR2(1), CAMK2B(1), CAMK2G(1), F2(3), FYN(1), GNA11(1), MAP2K2(1), MAPK1(1), MAPT(1), MYLK(3), PLCG1(1), PRKCA(1), PTK2B(2), SOS1(2), STAT1(2), STAT3(1), STAT5A(1), SYT1(2)	15383357	27	21	27	7	3	6	9	3	6	0	0.296	1.000	1.000
432	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	CASP2(1), CASP4(2), CASP8(1), LMNB1(1)	6982543	5	5	5	3	0	3	1	0	1	0	0.882	1.000	1.000
433	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	41	CASP2(1), CASP8(1), FAS(1), JUN(1), MAP2K4(2), MAPK10(2), MDM2(1), MYC(3), NFKB1(1), RELA(2), RIPK1(2), TNF(1), TNFRSF1A(1), TNFSF10(1), TRADD(1), TRAF2(2)	13349389	23	19	23	9	4	7	3	3	6	0	0.710	1.000	1.000
434	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(2), BTK(1), JUN(1), LYN(1), NFATC2(2), NFATC3(1), PLCG1(1), PPP3CB(1), PPP3CC(2), PRKCA(1), RAC1(1), SOS1(2), SYK(2), SYT1(2), VAV1(3)	13816409	23	22	23	9	4	2	8	3	6	0	0.786	1.000	1.000
435	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOB(3), FBP1(1), H6PD(2), PFKP(2), PGM1(1), TAL1(1), TKT(1)	7335752	11	9	11	7	3	1	5	0	2	0	0.891	1.000	1.000
436	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(1), ACAT1(2), ALDH1A3(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), AOX1(2), BCAT1(1), BCKDHA(1), DBT(1), HADHA(1), HMGCS2(2), HSD17B4(1), MCCC1(1), MUT(3), OXCT2(1)	15822118	22	20	22	7	2	4	4	5	7	0	0.623	1.000	1.000
437	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTN1(1), BCAR1(2), BCR(2), CAPN1(1), CAPNS1(1), FYN(1), ITGA1(1), JUN(1), MAP2K2(1), MAPK1(1), PPP1R12B(1), PTK2(3), RAP1A(1), ROCK1(1), SOS1(2), TLN1(2)	17533414	22	20	22	5	3	3	6	5	5	0	0.401	1.000	1.000
438	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(1), ABAT(1), ACAT1(2), ALDH1A2(1), ALDH1A3(2), ALDH2(1), ALDH9A1(1), GAD1(1), GAD2(2), HADHA(1), PDHA2(2), PDHB(1)	9391041	16	14	16	6	0	4	4	6	2	0	0.665	1.000	1.000
439	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	27	IRS1(1), JAK1(1), JAK3(2), MAP4K1(3), MAPK1(1), PIK3CA(6), PIK3CD(1), PIK3R1(1), PPP1R13B(1), SOS1(2)	13342134	19	17	18	8	4	0	5	4	6	0	0.849	1.000	1.000
440	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	35	ARHGEF11(2), DLG4(1), MAP2K4(2), MAP3K5(4), NFKB1(1), NFKBIL1(1), PHKA2(2), PI3(1), PIK3CB(1), PLD1(3), PLD2(1), PTK2(3), RDX(1), ROCK1(1), ROCK2(2), SERPINA4(1), SRF(1)	18312773	28	24	28	7	5	6	4	9	3	1	0.417	1.000	1.000
441	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	28	BAG4(1), CASP8(1), JUN(1), MAP2K4(2), MAP3K7(1), NFKB1(1), NFKBIL1(1), RIPK1(2), TNF(1), TNFRSF1A(1), TRADD(1), TRAF2(2)	10249352	15	15	15	5	2	5	4	1	3	0	0.567	1.000	1.000
442	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	57	ALG2(1), BFAR(2), BTK(1), CAD(4), CASP8(1), DAXX(1), DEDD(1), EGFR(3), EPHB2(1), FAF1(2), FAIM2(1), IL1A(1), MAP2K4(2), MAP2K7(3), MAP3K5(4), MAPK1(1), MAPK10(2), MAPK8IP3(3), MET(4), NFAT5(4), NFKB1(1), NFKBIL1(1), PFN2(1), RIPK1(2), ROCK1(1), TPX2(2), TRAF2(2)	26491749	52	42	52	10	6	18	10	7	11	0	0.0728	1.000	1.000
443	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(3), ATP4B(1), ATP5B(1), ATP5C1(1), ATP5J2(1), ATP5O(1), ATP6AP1(2), ATP6V0A4(1), ATP6V1A(2), ATP6V1E1(1), COX10(1), COX6A2(1), COX7C(1), LHPP(2), NDUFA13(1), NDUFA4(1), NDUFA7(2), NDUFB6(1), NDUFV3(1), SDHA(1), TCIRG1(1), UQCRB(1), UQCRC1(1)	20665347	29	28	29	7	4	4	13	2	6	0	0.348	1.000	1.000
444	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(1), ALOX12(2), ALOX15(1), ALOX5(2), CBR3(1), CYP4F2(2), EPX(2), GGT1(1), MPO(4), PLA2G4A(1), PTGIS(1), PTGS1(1), PTGS2(1), TBXAS1(1), TPO(1)	10522708	22	17	22	7	3	8	5	2	4	0	0.299	1.000	1.000
445	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	26	CASP8(1), DAXX(1), FAF1(2), JUN(1), LMNB1(1), MAP2K4(2), MAP3K7(1), PAK1(1), PRKDC(6), RIPK2(1), SPTAN1(4)	14972483	21	18	21	8	1	4	5	2	9	0	0.899	1.000	1.000
446	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	27	ADRBK1(1), ITPKA(1), ITPR1(4), ITPR2(6), ITPR3(2), NFKB1(1), NFKBIL1(1), PHKA2(2), PIK3CB(1), PLD1(3), PLD2(1), VN1R1(1)	16805137	24	22	24	6	8	5	3	4	4	0	0.292	1.000	1.000
447	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	GBA(1), GNS(2), GUSB(2), HPSE2(3), IDS(1), IDUA(4), LCT(5), MAN2B2(1), MAN2C1(1), NAGLU(1), NEU3(2), SPAM1(2)	12823598	25	20	25	9	7	3	7	2	5	1	0.419	1.000	1.000
448	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	18	DUSP1(1), IKBKAP(2), NFKB1(1), RELA(2), RIPK1(2), TRAF2(2)	8232383	10	10	10	6	1	5	2	1	1	0	0.876	1.000	1.000
449	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	46	FN3K(1), IMPA2(1), INPP1(2), INPP4A(2), INPP4B(1), INPP5A(1), INPP5B(3), INPPL1(1), ITPK1(2), ITPKA(1), OCRL(1), PI4KA(4), PI4KB(1), PIK3CA(6), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIP5K1A(1), PIP5K1B(1), PLCB1(5), PLCB2(2), PLCB3(2), PLCB4(3), PLCD3(1), PLCE1(6), PLCG1(1), PLCG2(2), PLCZ1(1), SYNJ1(2), SYNJ2(1)	27066838	59	43	58	12	13	16	8	10	12	0	0.0238	1.000	1.000
450	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(1), ALG11(2), ALG13(1), ALG14(1), ALG2(1), ALG3(1), ALG6(1), ALG9(1), DHDDS(1), FUT8(1), GANAB(1), MAN1A1(3), MAN1B1(1), MAN1C1(2), MGAT3(1), MGAT5(2), MGAT5B(2), RPN2(2)	15623630	25	20	25	7	3	7	6	3	5	1	0.315	1.000	1.000
451	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	ASNS(1), ASRGL1(1), CA12(1), CA2(3), CA3(1), CA4(1), CA9(1), CTH(1), GLS2(1), GLUL(2)	7679478	13	13	13	5	4	3	5	0	1	0	0.639	1.000	1.000
452	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	24	ATM(5), CDK4(1), DAZL(1), EGR1(1), ESR2(2), FSHR(1), GJA4(1), INHA(1), MLH1(1), NCOR1(1), NRIP1(3), PRLR(4), PTGER2(2)	11999877	24	19	24	8	1	6	8	6	3	0	0.637	1.000	1.000
453	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	EPO(1), JUN(1), PLCG1(1), SOS1(2), STAT5A(1)	8060821	6	6	6	3	1	0	3	1	1	0	0.852	1.000	1.000
454	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(2), GPRC5B(1), GPRC5C(3), GRM1(1), GRM3(5), GRM4(1), GRM5(4), GRM7(2), GRM8(2)	7419426	21	15	21	9	6	7	3	4	1	0	0.483	1.000	1.000
455	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B10(1), ALDOB(3), FBP1(1), FPGT(2), GMDS(1), GMPPA(2), HK2(2), KHK(1), LHPP(2), MTMR2(1), PFKFB1(1), PFKFB2(1), PFKFB4(3), PFKL(3), PFKP(2)	13897798	26	23	26	8	10	1	8	0	7	0	0.368	1.000	1.000
456	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(1)	8352425	1	1	1	3	0	0	0	0	1	0	0.998	1.000	1.000
457	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ACY1(1), AGMAT(1), ALDH18A1(1), ALDH1A3(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), AMD1(1), AOC3(1), ARG2(2), ASL(1), MAOB(1)	10791388	14	13	14	6	2	3	4	1	4	0	0.760	1.000	1.000
458	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA2C(1), CHRM1(1), CHRM2(2), CHRM4(1), CHRM5(1), DRD1(1), DRD2(1), DRD3(2), HTR1A(1), HTR1B(1), HTR1D(2), HTR2A(1), HTR4(1), HTR6(1)	9192732	17	15	17	7	3	7	5	2	0	0	0.335	1.000	1.000
459	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	CDK5R1(1), CHN1(1), LIMK1(3), MYLK(3), PAK1(1), PDGFRA(1), PIK3CA(6), PIK3R1(1), PLD1(3), PPP1R12B(1), RAC1(1), TRIO(4), VAV1(3)	12699503	29	24	28	9	7	3	8	8	3	0	0.527	1.000	1.000
460	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(2), APOA4(1), CETP(1), DGAT1(1), LIPC(3), LPL(2), LRP1(4), SCARB1(1), SOAT1(1)	9937050	16	15	16	8	2	4	7	1	2	0	0.739	1.000	1.000
461	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B10(1), G6PC2(1), GAA(1), GALK1(1), GCK(2), GLA(1), HK2(2), LCT(5), MGAM(5), PFKL(3), PFKP(2), PGM1(1), UGP2(2)	14253402	27	23	27	9	7	7	9	1	3	0	0.385	1.000	1.000
462	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(1), GNAS(2), JUN(1), NFATC2(2), NFATC3(1), PLCG1(1), PPP3CB(1), PPP3CC(2), PRKACG(1), PRKAR1B(1), PRKAR2B(1), PRKCA(1), SYT1(2)	12664412	17	16	17	6	3	1	7	2	4	0	0.785	1.000	1.000
463	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	GTF2B(1), HDAC3(1), NCOA1(4), NCOR2(5), RARA(1), RXRA(1)	9194027	13	12	13	5	3	3	3	3	1	0	0.649	1.000	1.000
464	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	70	ADH1A(1), ADH4(2), ADH6(1), ADH7(3), AKR1C3(1), AKR1C4(1), ALDH1A3(2), CYP1A2(2), CYP2C18(3), CYP2C19(2), CYP2C9(2), CYP2E1(3), CYP2F1(2), CYP2S1(2), CYP3A4(3), CYP3A7(2), DHDH(1), EPHX1(2), GSTA4(1), GSTM5(1), MGST1(1), UGT1A10(1), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT2A3(1), UGT2B11(3), UGT2B15(2), UGT2B17(2)	21106766	51	35	51	13	8	11	10	9	13	0	0.204	1.000	1.000
465	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	99	CASP8(1), CCL3(1), CD86(1), IFNA1(1), IFNA14(1), IFNA16(1), IFNA17(1), IFNA6(1), IFNA8(1), IFNAR1(1), IRF3(1), IRF5(1), JUN(1), LBP(1), MAP2K2(1), MAP2K3(2), MAP2K4(2), MAP2K6(2), MAP2K7(3), MAP3K7(1), MAPK1(1), MAPK10(2), MAPK11(1), NFKB1(1), PIK3CA(6), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(1), PIK3R3(1), RAC1(1), RELA(2), RIPK1(2), STAT1(2), TICAM1(2), TIRAP(1), TLR1(1), TLR2(3), TLR3(2), TLR4(1), TLR5(2), TLR8(1), TLR9(3), TNF(1), TOLLIP(1), TRAF6(2)	32386445	69	47	68	13	11	16	14	16	12	0	0.0217	1.000	1.000
466	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(1), ADH4(2), ADH6(1), ADH7(3), AGK(1), AGPAT6(2), ALDH1A3(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), CEL(5), DGAT1(1), DGKB(1), DGKD(3), DGKE(1), DGKG(3), DGKH(2), DGKI(1), DGKQ(1), DGKZ(1), GK2(2), GLA(1), GPAM(1), LCT(5), LIPA(1), LIPC(3), LIPF(1), LPL(2), PNLIPRP1(1), PNPLA3(1), PPAP2A(1), PPAP2B(2), PPAP2C(1)	21699876	56	41	55	15	5	10	17	10	13	1	0.407	1.000	1.000
467	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACADL(1), ACADSB(1), ACAT1(2), ACSL3(1), ACSL4(2), ACSL6(4), ADH1A(1), ADH4(2), ADH6(1), ADH7(3), ALDH1A3(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), CPT1A(1), CPT1B(1), CYP4A11(1), HADHA(1), HSD17B4(1)	17834756	28	25	28	9	4	1	8	9	6	0	0.726	1.000	1.000
468	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG2(1), ADCY3(1), ADCY9(1), ARF1(1), ARL4D(1), ATP6V0A4(1), ATP6V1A(2), ATP6V1E1(1), GNAS(2), PDIA4(1), PLCG1(1), PLCG2(2), PRKCA(1), SEC61A2(1), SEC61B(1)	13493111	18	16	18	8	2	5	4	4	3	0	0.771	1.000	1.000
469	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	37	CCNH(1), GTF2B(1), GTF2H1(1), POLR1A(1), POLR3E(1), TAF6(1)	12672490	6	6	6	5	1	1	1	0	3	0	0.956	1.000	1.000
470	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	CASP8(1), GAS2(1), NFKB1(1), RELA(2), RIPK1(2), SPTAN1(4), TNFRSF10B(1), TNFSF10(1), TRADD(1), TRAF2(2)	12204229	16	13	16	7	2	5	5	0	4	0	0.894	1.000	1.000
471	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	GAA(1), GALK1(1), GANAB(1), GCK(2), GLA(1), HK2(2), LCT(5), MGAM(5), PFKP(2), PGM1(1)	11957090	21	18	21	8	6	6	7	1	1	0	0.544	1.000	1.000
472	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	28	BRAF(1), EGFR(3), ERBB2(1), ERBB4(4), ETS1(1), ETV6(1), ETV7(1), FMN2(7), KRAS(2), MAPK1(1), NOTCH1(3), NOTCH2(2), NOTCH3(5), NOTCH4(6), PIWIL1(3), PIWIL2(1), PIWIL3(1), PIWIL4(1), SOS1(2), SPIRE1(2)	19515802	48	37	48	13	10	8	16	6	7	1	0.283	1.000	1.000
473	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	BRAF(1), DUSP9(1), MAP2K2(1), MAPK1(1), MKNK1(1), NFKB1(1), RAP1A(1), RPS6KA1(1), SOS1(2)	10901705	10	9	10	9	1	3	4	1	1	0	0.987	1.000	1.000
474	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	APC(5), CAMP(1), CAV3(1), DLG4(1), EPHB2(1), ITPR1(4), ITPR2(6), ITPR3(2), KCNJ3(1), KCNJ5(2), KCNJ9(1), MAPK1(1), RAC1(1), RHO(1), RYR1(16)	16875637	44	32	43	13	13	14	4	4	9	0	0.0830	1.000	1.000
475	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ADH1A(1), ADH4(2), ADH6(1), ADH7(3), ALDH1A3(2), AOC3(1), AOX1(2), CARM1(1), DBH(1), DCT(3), DDC(2), ESCO2(1), HEMK1(1), HPD(1), MAOB(1), PNPLA3(1), PRMT2(2), PRMT3(1), PRMT6(1), PRMT8(1), SH3GLB1(1), TAT(2), TH(1), TPO(1), TYR(2), WBSCR22(1)	21554841	37	26	37	10	6	13	6	4	8	0	0.325	1.000	1.000
476	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	37	GAB1(1), GCK(2), JUN(1), MAP2K4(2), MAP2K5(1), MAP2K7(3), MAP3K11(1), MAP3K12(1), MAP3K13(1), MAP3K4(1), MAP3K5(4), MAP3K7(1), MAP3K9(2), MAPK10(2), MAPK7(1), NFATC3(1), PAPPA(6), TRAF6(2), ZAK(4)	17935840	37	30	37	10	4	11	8	9	5	0	0.313	1.000	1.000
477	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	74	BTK(1), FCER1A(1), FYN(1), INPP5D(3), KRAS(2), LAT(1), LCP2(2), LYN(1), MAP2K2(1), MAP2K3(2), MAP2K4(2), MAP2K6(2), MAP2K7(3), MAPK1(1), MAPK10(2), MAPK11(1), MS4A2(3), NRAS(1), PIK3CA(6), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(1), PIK3R3(1), PLA2G12B(1), PLA2G2D(1), PLA2G4A(1), PLCG1(1), PLCG2(2), PRKCA(1), PRKCE(2), RAC1(1), SOS1(2), SYK(2), TNF(1), VAV1(3), VAV2(3), VAV3(1)	26529400	64	44	63	17	9	16	9	19	11	0	0.168	1.000	1.000
478	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS2(2), ADH1A(1), ADH4(2), ADH6(1), ADH7(3), ALDH1A3(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), ALDOB(3), DLAT(1), ENO1(1), ENO2(2), ENO3(1), FBP1(1), G6PC2(1), GAPDH(1), GCK(2), HK2(2), LDHB(1), PDHA2(2), PDHB(1), PFKL(3), PFKP(2), PGK2(1), PGM1(1), PKLR(2)	21366271	42	32	42	10	8	5	12	5	12	0	0.249	1.000	1.000
479	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	CASP2(1), CASP4(2), CASP8(1), CD40LG(1), DAXX(1), FAS(1), NFKB1(1), NGFR(1), NTRK1(3), RIPK1(2), TNF(1), TNFRSF1A(1), TRADD(1), TRAF2(2), TRAF6(2)	15953942	21	18	21	8	6	7	4	1	3	0	0.670	1.000	1.000
480	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AMY2B(4), ENPP1(3), ENPP3(2), GAA(1), GANAB(1), GBE1(4), GCK(2), GUSB(2), GYS2(1), HK2(2), MGAM(5), PGM1(1), PYGB(2), PYGM(3), RNPC3(2), SI(4), UCHL3(1), UGDH(2), UGT1A10(1), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT2B15(2)	21178895	49	35	48	12	11	15	6	6	11	0	0.160	1.000	1.000
481	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	ACHE(3), AGPAT6(2), CDIPT(1), CDS1(1), CHAT(2), DGKB(1), DGKD(3), DGKE(1), DGKG(3), DGKH(2), DGKI(1), DGKQ(1), DGKZ(1), ESCO2(1), ETNK2(1), GPAM(1), GPD2(2), PLA2G12B(1), PLA2G2D(1), PLA2G4A(1), PLD1(3), PLD2(1), PNPLA3(1), PPAP2A(1), PPAP2B(2), PPAP2C(1), SH3GLB1(1)	24037933	40	31	39	10	9	8	11	4	7	1	0.232	1.000	1.000
482	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	BCAR1(2), CAPN1(1), CAPN10(1), CAPN11(4), CAPN2(1), CAPN3(1), CAPN5(1), CAPN7(2), CAPN9(2), CAPNS1(1), CAV3(1), DOCK1(3), FYN(1), ITGA10(4), ITGA11(1), ITGA2(1), ITGA2B(2), ITGA3(2), ITGA4(2), ITGA6(3), ITGA7(1), ITGA8(1), ITGA9(1), ITGAD(3), ITGAE(1), ITGAL(2), ITGAM(2), ITGAV(3), ITGAX(1), ITGB2(1), ITGB4(4), ITGB6(2), ITGB7(2), ITGB8(1), MAP2K2(1), MAP2K3(2), MAP2K6(2), MAPK10(2), MAPK6(2), MAPK7(1), MYLK2(2), PAK1(1), PAK3(3), PAK4(1), PTK2(3), RAC1(1), RAPGEF1(1), RHO(1), ROCK1(1), ROCK2(2), SHC3(1), SORBS1(2), SOS1(2), TLN1(2), TNS1(1), VASP(1), VAV2(3), VAV3(1)	49803016	100	72	100	20	15	25	28	17	15	0	0.0101	1.000	1.000
483	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	CISH(2), IARS(1), IL2RG(1), INPP5D(3), JAK1(1), JAK3(2), PI3(1), PIK3CA(6), PPP1R13B(1), SERPINA4(1), SOS1(2), TYK2(1)	13550892	22	19	21	9	3	4	6	8	1	0	0.819	1.000	1.000
484	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	53	ADORA3(3), ALG6(1), CCKBR(2), CCR3(2), CELSR1(7), CELSR2(4), CELSR3(4), CHRM2(2), CIDEB(1), EDNRA(1), EMR2(2), EMR3(1), F2R(1), FSHR(1), GPR116(3), GPR132(1), GPR133(1), GPR135(1), GPR143(3), GPR55(1), GPR88(1), GRM1(1), GRPR(1), LGR6(1), LPHN2(4), LPHN3(2), NTSR1(2), OR2M4(1), P2RY11(1), VN1R1(1)	24025239	57	41	57	15	11	14	14	13	5	0	0.0575	1.000	1.000
485	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	44	BRAF(1), CAB39(2), FIGF(1), HIF1A(1), IGF1(1), MAPK1(1), PIK3CA(6), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(1), PIK3R3(1), PRKAA2(5), RICTOR(3), RPS6(1), RPS6KA1(1), TSC1(1), TSC2(4), ULK1(3), ULK2(2), ULK3(1), VEGFC(1)	19702923	41	30	40	11	6	13	7	7	7	1	0.264	1.000	1.000
486	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	93	CARD11(3), CBLB(2), CBLC(1), CD3G(1), CD40LG(1), CDK4(1), CTLA4(1), FYN(1), GRAP2(2), IFNG(1), ITK(1), JUN(1), KRAS(2), LAT(1), LCK(1), LCP2(2), NCK2(1), NFAT5(4), NFATC2(2), NFATC3(1), NFKB1(1), NRAS(1), PAK1(1), PAK3(3), PAK4(1), PAK7(1), PIK3CA(6), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(1), PIK3R3(1), PLCG1(1), PPP3CB(1), PPP3CC(2), PRKCQ(3), PTPRC(4), SOS1(2), TEC(2), TNF(1), VAV1(3), VAV2(3), VAV3(1), ZAP70(5)	37120582	78	55	77	16	12	19	20	14	13	0	0.0339	1.000	1.000
487	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	62	CDK2(1), CDKN2A(2), ERBB4(4), F2RL2(1), GAB1(1), IGF1(1), INPPL1(1), IRS1(1), IRS4(3), MET(4), MYC(3), NOLC1(1), PAK1(1), PAK3(3), PAK4(1), PAK7(1), PIK3CA(6), PIK3CD(1), PPP1R13B(1), PREX1(2), PTK2(3), PTPN1(1), RPS6KA1(1), SLC2A4(1), SOS1(2), TSC1(1), TSC2(4), YWHAE(2), YWHAQ(1)	27688431	55	47	53	15	9	13	11	10	12	0	0.355	1.000	1.000
488	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	63	BLNK(2), BTK(1), CARD11(3), CD19(1), CD22(1), CD72(1), CD81(1), CR2(2), FCGR2B(1), INPP5D(3), JUN(1), KRAS(2), LILRB3(1), LYN(1), NFAT5(4), NFATC2(2), NFATC3(1), NFKB1(1), NRAS(1), PIK3CA(6), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(1), PIK3R3(1), PLCG2(2), PPP3CB(1), PPP3CC(2), RAC1(1), SYK(2), VAV1(3), VAV2(3), VAV3(1)	27199129	57	40	56	15	7	14	15	8	13	0	0.213	1.000	1.000
489	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	49	CPT1B(1), CREBBP(4), DUSP1(1), EP300(2), HSD17B4(1), JUN(1), LPL(2), MAPK1(1), ME1(1), MYC(3), NCOA1(4), NCOR1(1), NCOR2(5), NRIP1(3), PIK3CA(6), PIK3R1(1), PPARA(1), PRKACG(1), PRKAR1B(1), PRKAR2B(1), PRKCA(1), PTGS2(1), RELA(2), RXRA(1), SP1(2), STAT5A(1), TNF(1)	22366006	50	39	49	15	10	9	11	9	11	0	0.508	1.000	1.000
490	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	81	AIFM1(1), ATM(5), CAPN1(1), CAPN2(1), CASP8(1), CSF2RB(2), FAS(1), IL1A(1), IRAK2(2), IRAK3(2), NFKB1(1), NTRK1(3), PIK3CA(6), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(1), PIK3R3(1), PPP3CB(1), PPP3CC(2), PRKACA(2), PRKACG(1), PRKAR1B(1), PRKAR2B(1), RELA(2), RIPK1(2), TNF(1), TNFRSF10B(1), TNFRSF10D(1), TNFRSF1A(1), TNFSF10(1), TRADD(1), TRAF2(2)	30530185	53	46	52	13	11	8	15	10	9	0	0.290	1.000	1.000
491	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	85	BRAF(1), DAXX(1), JUN(1), MAP2K2(1), MAP2K3(2), MAP2K4(2), MAP2K5(1), MAP2K6(2), MAP2K7(3), MAP3K11(1), MAP3K12(1), MAP3K13(1), MAP3K4(1), MAP3K5(4), MAP3K6(3), MAP3K7(1), MAP3K9(2), MAP4K1(3), MAP4K4(1), MAP4K5(1), MAPK1(1), MAPK10(2), MAPK11(1), MAPK6(2), MAPK7(1), MEF2B(2), MEF2C(1), MKNK1(1), MYC(3), NFKB1(1), PAK1(1), RAC1(1), RELA(2), RIPK1(2), RPS6KA1(1), SP1(2), STAT1(2), TGFB1(1), TGFBR1(1), TRADD(1), TRAF2(2)	36041521	64	41	64	14	9	21	12	12	10	0	0.0361	1.000	1.000
492	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	84	ANPEP(1), CD19(1), CD1A(1), CD1C(1), CD2(1), CD22(1), CD33(1), CD34(1), CD3G(1), CD55(1), CR1(3), CR2(2), CSF1R(2), CSF2RA(1), CSF3R(1), DNTT(1), EPO(1), FCER2(2), FLT3(2), HLA-DRB1(1), HLA-DRB5(1), IL1A(1), IL2RA(1), IL5RA(2), IL6R(2), IL7R(1), IL9R(2), ITGA1(1), ITGA2(1), ITGA2B(2), ITGA3(2), ITGA4(2), ITGA6(3), ITGAM(2), KIT(5), KITLG(1), MME(3), MS4A1(1), TNF(1), TPO(1)	30160592	61	43	61	16	7	15	18	8	12	1	0.225	1.000	1.000
493	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	84	ABL1(2), ABL2(1), BRAF(1), BTC(1), CAMK2B(1), CAMK2G(1), CBLB(2), CBLC(1), CDKN1A(2), EGFR(3), ERBB2(1), ERBB3(1), ERBB4(4), GAB1(1), JUN(1), KRAS(2), MAP2K2(1), MAP2K4(2), MAP2K7(3), MAPK1(1), MAPK10(2), MYC(3), NCK2(1), NRAS(1), NRG2(1), NRG3(1), PAK1(1), PAK3(3), PAK4(1), PAK7(1), PIK3CA(6), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(1), PIK3R3(1), PLCG1(1), PLCG2(2), PRKCA(1), PRKCG(1), PTK2(3), SHC3(1), SHC4(2), SOS1(2), STAT5A(1)	36993348	73	53	72	18	12	16	16	13	16	0	0.151	1.000	1.000
494	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	126	BRAF(1), CD48(1), FAS(1), FCGR3A(2), FYN(1), HCST(1), HLA-B(1), HLA-E(1), IFNA1(1), IFNA14(1), IFNA16(1), IFNA17(1), IFNA6(1), IFNA8(1), IFNAR1(1), IFNG(1), ITGAL(2), ITGB2(1), KIR3DL1(2), KIR3DL2(1), KLRC3(2), KRAS(2), LAT(1), LCK(1), LCP2(2), MAP2K2(1), MAPK1(1), MICA(1), MICB(1), NFAT5(4), NFATC2(2), NFATC3(1), NRAS(1), PAK1(1), PIK3CA(6), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(1), PIK3R3(1), PLCG1(1), PLCG2(2), PPP3CB(1), PPP3CC(2), PRKCA(1), PRKCG(1), PTK2B(2), PTPN11(3), RAC1(1), SHC3(1), SHC4(2), SOS1(2), SYK(2), TNF(1), TNFRSF10B(1), TNFRSF10D(1), TNFSF10(1), ULBP1(1), VAV1(3), VAV2(3), VAV3(1), ZAP70(5)	41567290	94	64	93	24	13	22	23	21	15	0	0.103	1.000	1.000
495	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	42	CREBBP(4), CTBP1(3), CTBP2(1), DLL3(1), DTX1(3), DTX2(3), DTX3(2), DTX4(2), DVL1(2), DVL2(1), EP300(2), JAG1(4), JAG2(1), MAML1(1), MAML2(2), MAML3(4), NCOR2(5), NCSTN(1), NOTCH1(3), NOTCH2(2), NOTCH3(5), NOTCH4(6), PSEN2(1), SNW1(2)	26056056	61	40	61	19	15	15	8	8	14	1	0.248	1.000	1.000
496	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	109	ACTN1(1), ACTN4(3), ARHGAP5(2), BCAR1(2), CDH5(1), CLDN1(2), CLDN10(1), CLDN15(1), CLDN2(2), CLDN20(1), CLDN4(1), CLDN6(1), CLDN8(1), CTNNA1(2), CTNNA2(5), CTNNA3(3), CTNND1(4), CYBB(1), EZR(1), F11R(4), ITGA4(2), ITGAL(2), ITGAM(2), ITGB2(1), ITK(1), MAPK11(1), MLLT4(1), MMP2(2), MMP9(1), MYL5(1), NCF4(1), NOX1(2), OCLN(1), PIK3CA(6), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(1), PIK3R3(1), PLCG1(1), PLCG2(2), PRKCA(1), PRKCG(1), PTK2(3), PTK2B(2), PTPN11(3), RAC1(1), RAP1A(1), RAPGEF4(1), ROCK1(1), ROCK2(2), SIPA1(1), TXK(1), VASP(1), VAV1(3), VAV2(3), VAV3(1), VCAM1(1)	45756268	99	62	98	22	15	26	19	23	16	0	0.0147	1.000	1.000
497	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	72	CDIPT(1), CDS1(1), DGKB(1), DGKD(3), DGKE(1), DGKG(3), DGKH(2), DGKI(1), DGKQ(1), DGKZ(1), FN3K(1), IMPA2(1), INPP1(2), INPP4A(2), INPP4B(1), INPP5A(1), INPP5B(3), INPP5D(3), INPPL1(1), ITPK1(2), ITPKA(1), ITPR1(4), ITPR2(6), ITPR3(2), OCRL(1), PI4KA(4), PI4KB(1), PIK3C2G(7), PIK3CA(6), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(1), PIK3R3(1), PIP5K1A(1), PIP5K1B(1), PLCB1(5), PLCB2(2), PLCB3(2), PLCB4(3), PLCD3(1), PLCE1(6), PLCG1(1), PLCG2(2), PLCZ1(1), PRKCA(1), PRKCG(1), SYNJ1(2), SYNJ2(1)	46060216	100	67	98	25	19	24	19	18	20	0	0.0554	1.000	1.000
498	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	69	KDR(4), KRAS(2), MAP2K2(1), MAPK1(1), MAPK11(1), NFAT5(4), NFATC2(2), NFATC3(1), NOS3(3), NRAS(1), PIK3CA(6), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(1), PIK3R3(1), PLA2G12B(1), PLA2G2D(1), PLA2G4A(1), PLCG1(1), PLCG2(2), PPP3CB(1), PPP3CC(2), PRKCA(1), PRKCG(1), PTGS2(1), PTK2(3), RAC1(1), SPHK2(2)	26614616	50	42	49	15	6	7	14	12	11	0	0.517	1.000	1.000
499	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(3), CDIPT(1), CDS1(1), CHAT(2), CPT1B(1), DGKB(1), DGKD(3), DGKE(1), DGKG(3), DGKH(2), DGKQ(1), DGKZ(1), GPD2(2), PAFAH2(2), PLA2G4A(1), PLCB2(2), PLCG1(1), PLCG2(2), PPAP2A(1), PPAP2B(2), PPAP2C(1)	18532497	34	29	33	11	7	7	8	7	4	1	0.479	1.000	1.000
500	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	77	ABL1(2), ACTN1(1), ANGPTL2(2), ARHGEF6(2), ARHGEF7(1), BCAR1(2), BRAF(1), CDKN2A(2), CSE1L(1), DOCK1(3), EPHB2(1), FYN(1), ITGA1(1), ITGA10(4), ITGA11(1), ITGA2(1), ITGA3(2), ITGA4(2), ITGA6(3), ITGA7(1), ITGA8(1), ITGA9(1), MAP2K4(2), MAP2K7(3), MAP3K11(1), MAPK1(1), MAPK10(2), MAPK8IP3(3), MYLK(3), MYLK2(2), PAK1(1), PAK3(3), PAK4(1), PAK7(1), PIK3CA(6), PIK3CB(1), PKLR(2), PLCG1(1), PLCG2(2), PTK2(3), RHO(1), ROCK1(1), ROCK2(2), SOS1(2), TLN1(2), TLN2(6), VASP(1)	44617283	89	68	88	21	14	21	22	18	14	0	0.0979	1.000	1.000
501	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	32	BCR(2), BTK(1), CD19(1), CDKN2A(2), GAB1(1), ITPR1(4), ITPR2(6), ITPR3(2), LYN(1), PIK3CA(6), PLCG2(2), PPP1R13B(1), PREX1(2), PTPRC(4), RPS6KA1(1), SAG(1), SYK(2), TEC(2), VAV1(3)	20221115	44	42	43	14	12	4	11	9	8	0	0.471	1.000	1.000
502	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	BRAF(1), DRD2(1), EGFR(3), EPHB2(1), ITPKA(1), ITPR1(4), ITPR2(6), ITPR3(2), KCNJ3(1), KCNJ5(2), KCNJ9(1), MAPK1(1), PI3(1), PIK3CB(1), PLCB1(5), PLCB2(2), PLCB3(2), PLCB4(3), SOS1(2), STAT3(1)	21397845	41	26	41	13	9	12	4	11	5	0	0.304	1.000	1.000
503	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	89	ACVR1(2), ACVR1B(1), ACVR2B(1), AMHR2(1), BMP5(1), BMP6(1), BMPR2(1), CHRD(2), COMP(3), CREBBP(4), CUL1(3), E2F4(2), E2F5(1), EP300(2), FST(1), GDF6(1), ID3(1), ID4(1), IFNG(1), INHBA(2), LTBP1(4), MAPK1(1), MYC(3), PPP2R1A(2), PPP2R1B(2), PPP2R2A(1), PPP2R2B(1), PPP2R2C(2), ROCK1(1), ROCK2(2), SMAD3(2), SMURF2(1), SP1(2), TFDP1(1), TGFB1(1), TGFBR1(1), TGFBR2(1), THBS1(3), THBS3(2), TNF(1), ZFYVE9(4)	35900428	70	47	70	19	11	15	16	13	15	0	0.244	1.000	1.000
504	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	43	ANGPTL2(2), ARHGEF11(2), BTK(1), GDI1(1), INPPL1(1), ITPR1(4), ITPR2(6), ITPR3(2), LIMK1(3), MYLK(3), MYLK2(2), PAK1(1), PAK3(3), PAK4(1), PAK7(1), PIK3CA(6), PIK3CD(1), PIK3CG(2), PIK3R1(1), PPP1R13B(1), RHO(1), ROCK1(1), ROCK2(2), SAG(1)	25412772	49	40	48	15	10	10	11	11	7	0	0.406	1.000	1.000
505	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP5(1), BMP6(1), BTRC(2), CSNK1G3(1), DHH(2), GLI1(4), GLI2(1), GLI3(1), HHIP(2), LRP2(12), PRKACA(2), PRKACG(1), PTCH1(1), PTCH2(1), STK36(3), SUFU(2), WNT10B(1), WNT2(1), WNT2B(1), WNT5A(1), WNT7B(1), WNT8A(1), WNT8B(1), ZIC2(1)	21829985	45	33	45	15	5	10	12	11	7	0	0.354	1.000	1.000
506	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	190	ACTB(3), ACTN1(1), ACTN4(3), ARHGAP5(2), BCAR1(2), BRAF(1), CAPN2(1), CAV3(1), CCND1(1), CHAD(1), COL11A1(3), COL11A2(9), COL1A1(3), COL1A2(1), COL2A1(1), COL4A1(6), COL4A2(3), COL4A4(4), COL4A6(4), COL5A2(1), COL5A3(10), COL6A1(2), COL6A3(4), COL6A6(4), COMP(3), DIAPH1(2), DOCK1(3), EGFR(3), ERBB2(1), FARP2(2), FIGF(1), FLNA(4), FLNB(2), FLNC(3), FLT1(3), FN1(3), FYN(1), HGF(2), IGF1(1), IGF1R(2), ITGA1(1), ITGA10(4), ITGA11(1), ITGA2(1), ITGA2B(2), ITGA3(2), ITGA4(2), ITGA6(3), ITGA7(1), ITGA8(1), ITGA9(1), ITGAV(3), ITGB4(4), ITGB6(2), ITGB7(2), ITGB8(1), JUN(1), KDR(4), LAMA1(7), LAMA2(5), LAMA3(5), LAMA4(2), LAMA5(6), LAMB1(2), LAMB2(1), LAMB3(3), LAMB4(1), LAMC1(3), LAMC2(2), LAMC3(3), MAPK1(1), MAPK10(2), MET(4), MYL5(1), MYLK(3), MYLK2(2), PAK1(1), PAK3(3), PAK4(1), PAK7(1), PARVG(1), PDGFB(1), PDGFD(3), PDGFRA(1), PDGFRB(2), PIK3CA(6), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(1), PIK3R3(1), PPP1R12A(2), PRKCA(1), PRKCG(1), PTK2(3), RAC1(1), RAP1A(1), RAPGEF1(1), RELN(6), ROCK1(1), ROCK2(2), SHC3(1), SHC4(2), SOS1(2), THBS1(3), THBS3(2), TLN1(2), TLN2(6), TNC(6), TNN(2), TNR(8), TNXB(6), VASP(1), VAV1(3), VAV2(3), VAV3(1), VEGFC(1), VTN(3), VWF(4)	136160576	297	137	296	86	41	87	63	56	49	1	0.0215	1.000	1.000
507	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	167	ADCY1(1), ADCY2(3), ADCY3(1), ADCY4(1), ADCY7(1), ADCY8(2), ADCY9(1), ADORA2A(1), AGTR1(2), ATP2A1(1), ATP2A2(2), ATP2A3(3), ATP2B1(3), ATP2B2(2), ATP2B4(1), BDKRB1(1), BST1(2), CACNA1A(7), CACNA1B(7), CACNA1C(4), CACNA1D(2), CACNA1E(4), CACNA1F(5), CACNA1G(3), CACNA1H(4), CACNA1I(3), CACNA1S(6), CAMK2B(1), CAMK2G(1), CCKAR(1), CCKBR(2), CHRM1(1), CHRM2(2), CHRM5(1), CHRNA7(1), CYSLTR2(2), DRD1(1), EDNRA(1), EGFR(3), ERBB2(1), ERBB3(1), ERBB4(4), F2R(1), GNA11(1), GNAL(1), GNAS(2), GRIN1(2), GRIN2A(3), GRIN2D(2), GRM1(1), GRM5(4), GRPR(1), HTR2A(1), HTR4(1), HTR6(1), ITPKA(1), ITPR1(4), ITPR2(6), ITPR3(2), MYLK(3), MYLK2(2), NOS1(7), NOS3(3), NTSR1(2), P2RX2(1), P2RX7(1), PDE1A(2), PDE1B(3), PDE1C(4), PDGFRA(1), PDGFRB(2), PHKA1(4), PHKA2(2), PHKB(2), PHKG1(1), PLCB1(5), PLCB2(2), PLCB3(2), PLCB4(3), PLCD3(1), PLCE1(6), PLCG1(1), PLCG2(2), PLCZ1(1), PPP3CB(1), PPP3CC(2), PRKACA(2), PRKACG(1), PRKCA(1), PRKCG(1), PTAFR(1), PTK2B(2), RYR1(16), RYR2(16), RYR3(7), SLC8A1(2), SLC8A2(3), SLC8A3(5), SPHK2(2), TACR1(2), TRHR(1), TRPC1(1), VDAC1(1)	101032741	260	128	258	96	53	68	54	38	46	1	0.128	1.000	1.000
508	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	246	ACVR1B(1), ARRB1(1), BRAF(1), CACNA1A(7), CACNA1B(7), CACNA1C(4), CACNA1D(2), CACNA1E(4), CACNA1F(5), CACNA1G(3), CACNA1H(4), CACNA1I(3), CACNA1S(6), CACNA2D1(2), CACNA2D3(2), CACNA2D4(1), CACNB1(1), CACNB2(1), CACNB4(1), CACNG3(2), CACNG5(2), CACNG6(1), CACNG8(2), CDC25B(1), DAXX(1), DUSP1(1), DUSP5(1), DUSP7(3), DUSP9(1), ECSIT(2), EGFR(3), FAS(1), FGF13(3), FGF17(1), FGF18(1), FGF23(1), FGF3(2), FGFR1(3), FGFR2(1), FGFR3(1), FGFR4(2), FLNA(4), FLNB(2), FLNC(3), IL1A(1), JUN(1), KRAS(2), MAP2K2(1), MAP2K3(2), MAP2K4(2), MAP2K5(1), MAP2K6(2), MAP2K7(3), MAP3K12(1), MAP3K13(1), MAP3K4(1), MAP3K5(4), MAP3K6(3), MAP3K7(1), MAP4K1(3), MAP4K4(1), MAPK1(1), MAPK10(2), MAPK11(1), MAPK7(1), MAPK8IP3(3), MAPT(1), MEF2C(1), MKNK1(1), MYC(3), NF1(11), NFATC2(2), NFKB1(1), NR4A1(1), NRAS(1), NTRK1(3), NTRK2(3), PAK1(1), PDGFB(1), PDGFRA(1), PDGFRB(2), PLA2G12B(1), PLA2G2D(1), PLA2G4A(1), PPP3CB(1), PPP3CC(2), PPP5C(1), PRKACA(2), PRKACG(1), PRKCA(1), PRKCG(1), PTPN5(2), PTPN7(2), PTPRR(2), RAC1(1), RAP1A(1), RAPGEF2(2), RASA1(3), RASGRF1(4), RASGRF2(4), RPS6KA1(1), RRAS(1), SOS1(2), SRF(1), STK4(1), TAOK1(2), TAOK2(1), TGFB1(1), TGFBR1(1), TGFBR2(1), TNF(1), TNFRSF1A(1), TRAF2(2), TRAF6(2), ZAK(4)	107373014	227	119	226	77	40	54	53	37	42	1	0.254	1.000	1.000
509	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	136	ACTB(3), CHAD(1), COL11A1(3), COL11A2(9), COL17A1(4), COL1A1(3), COL1A2(1), COL2A1(1), COL4A1(6), COL4A2(3), COL4A4(4), COL4A6(4), COL5A2(1), COL5A3(10), COL6A1(2), COL6A3(4), COL6A6(4), COMP(3), DSC3(3), DSG1(1), DSG2(4), DSG3(1), DSG4(2), FN1(3), GJA4(1), GJA5(2), GJA8(1), GJB1(1), GJB2(1), GJD2(2), INA(1), ITGA6(3), ITGB4(4), KRT1(2), KRT10(2), KRT12(1), KRT14(4), KRT15(1), KRT16(1), KRT18(1), KRT20(1), KRT23(1), KRT27(1), KRT3(2), KRT33B(2), KRT36(1), KRT4(3), KRT5(3), KRT6A(1), KRT6B(1), KRT6C(2), KRT71(1), KRT72(1), KRT73(1), KRT74(1), KRT75(2), KRT76(1), KRT77(2), KRT78(1), KRT79(1), KRT8(1), KRT81(1), KRT82(1), KRT84(1), KRT85(2), KRT86(1), LAMA1(7), LAMA2(5), LAMA3(5), LAMA4(2), LAMA5(6), LAMB1(2), LAMB2(1), LAMB3(3), LAMB4(1), LAMC1(3), LAMC2(2), LAMC3(3), LMNB1(1), NES(2), RELN(6), THBS1(3), THBS3(2), TNC(6), TNN(2), TNR(8), TNXB(6), VTN(3), VWF(4)	91990074	227	113	227	82	38	75	40	34	38	2	0.274	1.000	1.000
510	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	201	ACTN1(1), ACTN4(3), APC(5), ARHGEF1(1), ARHGEF12(2), ARHGEF4(1), ARHGEF6(2), ARHGEF7(1), ARPC1B(1), ARPC5(1), BAIAP2(3), BCAR1(2), BDKRB1(1), BRAF(1), CHRM1(1), CHRM2(2), CHRM4(1), CHRM5(1), CYFIP1(1), CYFIP2(3), DIAPH1(2), DIAPH2(4), DOCK1(3), EGFR(3), EZR(1), F2(3), F2R(1), FGD1(1), FGD3(4), FGF13(3), FGF17(1), FGF18(1), FGF23(1), FGF3(2), FGFR1(3), FGFR2(1), FGFR3(1), FGFR4(2), FN1(3), IQGAP1(4), IQGAP3(2), ITGA1(1), ITGA10(4), ITGA11(1), ITGA2(1), ITGA2B(2), ITGA3(2), ITGA4(2), ITGA6(3), ITGA7(1), ITGA8(1), ITGA9(1), ITGAD(3), ITGAE(1), ITGAL(2), ITGAM(2), ITGAV(3), ITGAX(1), ITGB2(1), ITGB4(4), ITGB6(2), ITGB7(2), ITGB8(1), KRAS(2), LIMK1(3), MAP2K2(1), MAPK1(1), MYH10(3), MYH14(4), MYH9(4), MYL5(1), MYLK(3), MYLK2(2), NCKAP1(2), NCKAP1L(1), NRAS(1), PAK1(1), PAK3(3), PAK4(1), PAK7(1), PDGFB(1), PDGFRA(1), PDGFRB(2), PFN2(1), PIK3CA(6), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(1), PIK3R3(1), PIP5K1A(1), PIP5K1B(1), PPP1R12A(2), PPP1R12B(1), PTK2(3), RAC1(1), RDX(1), ROCK1(1), ROCK2(2), RRAS(1), SCIN(1), SLC9A1(1), SOS1(2), SSH1(2), SSH3(2), TIAM1(1), TIAM2(1), VAV1(3), VAV2(3), VAV3(1)	101756728	203	113	202	52	30	50	57	31	35	0	0.0148	1.000	1.000
511	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	236	ADORA2A(1), ADORA3(3), ADRA2B(1), ADRA2C(1), AGTR1(2), AGTR2(1), BDKRB1(1), C3AR1(1), CALCR(3), CALCRL(1), CCKAR(1), CCKBR(2), CHRM1(1), CHRM2(2), CHRM4(1), CHRM5(1), CNR1(3), CRHR2(4), CTSG(1), CYSLTR2(2), DRD1(1), DRD2(1), DRD3(2), EDNRA(1), F2(3), F2R(1), F2RL2(1), FSHR(1), GABRA1(1), GABRA2(2), GABRA4(1), GABRA5(2), GABRA6(2), GABRB2(1), GABRD(2), GABRE(1), GABRG1(2), GABRG3(1), GABRP(1), GABRQ(1), GABRR1(5), GHSR(2), GLP1R(2), GLP2R(2), GLRA1(3), GLRA3(2), GPR156(3), GPR50(2), GPR63(1), GPR83(3), GRIA1(6), GRIA3(1), GRIA4(2), GRID1(1), GRID2(3), GRIK1(2), GRIK2(2), GRIK3(4), GRIK4(3), GRIK5(2), GRIN1(2), GRIN2A(3), GRIN2D(2), GRIN3A(4), GRIN3B(1), GRM1(1), GRM3(5), GRM4(1), GRM5(4), GRM7(2), GRM8(2), GRPR(1), HCRTR2(1), HRH3(1), HTR1A(1), HTR1B(1), HTR1D(2), HTR2A(1), HTR4(1), HTR6(1), MC4R(1), MTNR1A(1), NMUR1(1), NMUR2(2), NPBWR2(1), NTSR1(2), NTSR2(1), OPRM1(1), P2RX2(1), P2RX7(1), P2RY10(1), P2RY11(1), P2RY2(1), P2RY4(1), P2RY6(1), PRLHR(4), PRLR(4), PRSS1(2), PTAFR(1), PTGER2(2), PTGIR(1), PTH2R(2), RXFP1(1), RXFP2(4), SCTR(3), SSTR3(1), TAAR2(1), TAAR6(1), TACR1(2), THRA(1), TRHR(1), VIPR1(3)	79174062	200	102	200	79	40	54	53	37	16	0	0.291	1.000	1.000
512	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	127	ABL1(2), ABLIM1(1), ABLIM2(1), ARHGEF12(2), DCC(7), DPYSL5(2), EFNB3(1), EPHA1(1), EPHA2(2), EPHA3(3), EPHA4(2), EPHA5(4), EPHA6(3), EPHA7(4), EPHA8(4), EPHB1(2), EPHB2(1), EPHB4(1), EPHB6(3), FES(1), FYN(1), KRAS(2), L1CAM(1), LIMK1(3), LRRC4C(1), MAPK1(1), MET(4), NCK2(1), NFAT5(4), NFATC2(2), NFATC3(1), NGEF(1), NRAS(1), NTN1(1), NTN4(1), PAK1(1), PAK3(3), PAK4(1), PAK7(1), PLXNA1(2), PLXNA2(3), PLXNA3(1), PLXNB1(5), PLXNB2(1), PLXNB3(3), PPP3CB(1), PPP3CC(2), PTK2(3), RAC1(1), RASA1(3), ROBO1(1), ROBO2(3), ROBO3(5), ROCK1(1), ROCK2(2), SEMA3A(2), SEMA3C(1), SEMA3D(1), SEMA3F(1), SEMA4B(1), SEMA4D(2), SEMA4F(1), SEMA5A(2), SEMA5B(2), SEMA6A(2), SEMA6B(1), SEMA6D(3), SLIT2(4), SLIT3(4), SRGAP1(3), SRGAP3(4), UNC5A(4), UNC5B(3), UNC5C(2), UNC5D(1)	72084020	159	100	159	52	25	35	49	25	25	0	0.368	1.000	1.000
513	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(1), CHAD(1), COL11A1(3), COL11A2(9), COL1A1(3), COL1A2(1), COL2A1(1), COL4A1(6), COL4A2(3), COL4A4(4), COL4A6(4), COL5A2(1), COL5A3(10), COL6A1(2), COL6A3(4), COL6A6(4), FN1(3), GP6(1), HMMR(1), HSPG2(6), ITGA1(1), ITGA10(4), ITGA11(1), ITGA2(1), ITGA2B(2), ITGA3(2), ITGA4(2), ITGA6(3), ITGA7(1), ITGA8(1), ITGA9(1), ITGAV(3), ITGB4(4), ITGB6(2), ITGB7(2), ITGB8(1), LAMA1(7), LAMA2(5), LAMA3(5), LAMA4(2), LAMA5(6), LAMB1(2), LAMB2(1), LAMB3(3), LAMB4(1), LAMC1(3), LAMC2(2), LAMC3(3), RELN(6), SV2A(1), SV2B(3), SV2C(3), THBS1(3), THBS3(2), TNC(6), TNN(2), TNR(8), TNXB(6), VTN(3), VWF(4)	83157689	186	100	186	61	29	52	42	31	31	1	0.224	1.000	1.000
514	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	129	ACTB(3), ACTN1(1), ACTN4(3), ASH1L(3), CDK4(1), CGN(1), CLDN1(2), CLDN10(1), CLDN15(1), CLDN2(2), CLDN20(1), CLDN4(1), CLDN6(1), CLDN8(1), CTNNA1(2), CTNNA2(5), CTNNA3(3), CTTN(3), EPB41(1), EPB41L1(1), EPB41L3(1), F11R(4), HCLS1(3), KRAS(2), LLGL2(1), MAGI1(3), MAGI2(3), MAGI3(2), MLLT4(1), MPDZ(3), MPP5(1), MYH1(4), MYH10(3), MYH11(5), MYH13(3), MYH14(4), MYH15(4), MYH2(6), MYH3(4), MYH4(6), MYH6(2), MYH7(7), MYH7B(4), MYH8(1), MYH9(4), MYL5(1), NRAS(1), OCLN(1), PARD6B(1), PPP2R1A(2), PPP2R1B(2), PPP2R2A(1), PPP2R2B(1), PPP2R2C(2), PPP2R3A(1), PPP2R3B(1), PRKCA(1), PRKCE(2), PRKCG(1), PRKCH(1), PRKCI(1), PRKCQ(3), RRAS(1), SPTAN1(4), SYMPK(2), TJAP1(1), TJP1(1), TJP2(5), TJP3(2), YES1(1), ZAK(4)	71436331	162	96	162	44	23	35	42	24	38	0	0.153	1.000	1.000
515	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(1), ADCY2(3), ADCY3(1), ADCY4(1), ADCY5(1), ADCY7(1), ADCY8(2), ADCY9(1), ANXA6(2), ARRB1(1), ATP1A4(3), ATP1B2(1), ATP2A2(2), ATP2A3(3), ATP2B1(3), ATP2B2(2), CACNA1A(7), CACNA1B(7), CACNA1C(4), CACNA1D(2), CACNA1E(4), CACNA1S(6), CACNB1(1), CAMK2B(1), CAMK2G(1), CHRM1(1), CHRM2(2), CHRM4(1), CHRM5(1), GJA4(1), GJA5(2), GJB1(1), GJB2(1), GNA11(1), GNAO1(1), GNAZ(2), GNB2(1), GRK4(1), GRK5(1), ITPR1(4), ITPR2(6), ITPR3(2), KCNB1(1), KCNJ3(1), KCNJ5(2), PKIB(1), PLCB3(2), PRKACA(2), PRKAR1B(1), PRKAR2B(1), PRKCA(1), PRKCE(2), PRKCG(1), PRKCH(1), PRKCQ(3), PRKD1(1), RGS11(1), RGS17(1), RGS18(1), RGS2(1), RGS6(1), RGS7(2), RYR1(16), RYR2(16), RYR3(7), SLC8A1(2), SLC8A3(5), YWHAQ(1)	70820375	164	88	162	64	30	48	35	19	32	0	0.244	1.000	1.000
516	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	131	ACACA(1), ACACB(4), BRAF(1), CBLB(2), CBLC(1), EXOC7(2), FASN(5), FBP1(1), G6PC2(1), GCK(2), GYS2(1), INPP5D(3), IRS1(1), IRS4(3), KRAS(2), MAP2K2(1), MAPK1(1), MAPK10(2), MKNK1(1), NRAS(1), PDE3A(1), PDE3B(5), PFKL(3), PFKP(2), PHKA1(4), PHKA2(2), PHKB(2), PHKG1(1), PIK3CA(6), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(1), PIK3R3(1), PKLR(2), PPARGC1A(1), PPP1R3A(6), PRKAA2(5), PRKAB2(1), PRKACA(2), PRKACG(1), PRKAR1B(1), PRKAR2B(1), PRKCI(1), PTPN1(1), PTPRF(2), PYGB(2), PYGM(3), RAPGEF1(1), RPS6(1), SHC3(1), SHC4(2), SLC2A4(1), SOCS2(1), SORBS1(2), SOS1(2), SREBF1(3), TRIP10(1), TSC1(1), TSC2(4)	59157530	117	86	116	34	14	25	31	28	19	0	0.248	1.000	1.000
517	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	250	ACVR1(2), ACVR1B(1), ACVR2B(1), AMHR2(1), BMPR2(1), CCL15(1), CCL16(1), CCL23(1), CCL3(1), CCR1(2), CCR3(2), CCR4(1), CD40LG(1), CNTFR(1), CSF1R(2), CSF2RA(1), CSF2RB(2), CSF3R(1), CX3CL1(3), CXCL14(2), CXCL5(1), CXCR6(2), EDA2R(1), EGFR(3), EPO(1), FAS(1), FLT1(3), FLT3(2), FLT4(2), HGF(2), IFNA1(1), IFNA14(1), IFNA16(1), IFNA17(1), IFNA6(1), IFNA8(1), IFNAR1(1), IFNG(1), IFNW1(2), IL10RA(2), IL12RB1(1), IL12RB2(3), IL17A(1), IL17B(1), IL17RA(2), IL18R1(1), IL18RAP(2), IL1A(1), IL20RA(1), IL21R(1), IL22RA1(1), IL23A(1), IL23R(1), IL25(1), IL26(1), IL2RA(1), IL2RB(5), IL2RG(1), IL5RA(2), IL6R(2), IL7R(1), IL9R(2), INHBA(2), KDR(4), KIT(5), KITLG(1), LIFR(1), MET(4), NGFR(1), PDGFB(1), PDGFRA(1), PDGFRB(2), PLEKHO2(1), PRLR(4), TGFB1(1), TGFBR1(1), TGFBR2(1), TNF(1), TNFRSF10B(1), TNFRSF10D(1), TNFRSF19(1), TNFRSF1A(1), TNFRSF21(3), TNFRSF8(1), TNFRSF9(2), TNFSF10(1), TNFSF15(1), TNFSF18(1), TPO(1), VEGFC(1), XCR1(1)	64386030	138	82	138	36	23	36	32	23	23	1	0.0219	1.000	1.000
518	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ACTA2(2), ADCY1(1), ADCY2(3), ADCY3(1), ADCY4(1), ADCY5(1), ADCY7(1), ADCY8(2), ADCY9(1), ARRB1(1), ATP2A2(2), ATP2A3(3), CAMK2B(1), CAMK2G(1), CNN1(1), CNN2(1), CORIN(2), DGKZ(1), GBA2(3), GNB2(1), GRK4(1), GRK5(1), GUCY1A3(1), IGFBP4(1), ITPR1(4), ITPR2(6), ITPR3(2), JUN(1), MYLK2(2), NFKB1(1), NOS1(7), NOS3(3), PDE4B(1), PDE4D(2), PKIB(1), PLCB3(2), PLCG1(1), PLCG2(2), PRKACA(2), PRKAR1B(1), PRKAR2B(1), PRKCA(1), PRKCE(2), PRKCH(1), PRKCQ(3), PRKD1(1), RGS11(1), RGS17(1), RGS18(1), RGS2(1), RGS6(1), RGS7(2), RLN1(1), RYR1(16), RYR2(16), RYR3(7), SLC8A1(2), SP1(2), TNXB(6), YWHAQ(1)	64988122	139	81	138	60	23	43	30	15	28	0	0.605	1.000	1.000
519	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	143	APC(5), AXIN1(1), AXIN2(2), BTRC(2), CAMK2B(1), CAMK2G(1), CCND1(1), CHD8(4), CREBBP(4), CTBP1(3), CTBP2(1), CUL1(3), DAAM1(1), DAAM2(1), DKK2(1), DVL1(2), DVL2(1), EP300(2), FZD10(1), FZD2(2), FZD3(2), FZD5(1), FZD6(1), JUN(1), LRP5(2), MAP3K7(1), MAPK10(2), MMP7(1), MYC(3), NFAT5(4), NFATC2(2), NFATC3(1), NKD2(2), PLCB1(5), PLCB2(2), PLCB3(2), PLCB4(3), PORCN(2), PPP2R1A(2), PPP2R1B(2), PPP2R2A(1), PPP2R2B(1), PPP2R2C(2), PPP3CB(1), PPP3CC(2), PRICKLE1(1), PRKACA(2), PRKACG(1), PRKCA(1), PRKCG(1), RAC1(1), ROCK1(1), ROCK2(2), RUVBL1(1), SFRP4(1), SMAD3(2), SOX17(1), TBL1Y(2), TCF7L1(1), TCF7L2(1), VANGL1(2), WIF1(4), WNT10B(1), WNT2(1), WNT2B(1), WNT5A(1), WNT7B(1), WNT8A(1), WNT8B(1)	58045967	119	75	119	32	18	25	32	17	27	0	0.108	1.000	1.000
520	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	BRAF(1), CACNA1A(7), GNA11(1), GNAO1(1), GNAS(2), GNAZ(2), GRIA1(6), GRIA3(1), GRID2(3), GRM1(1), GRM5(4), GUCY1A3(1), GUCY1B3(2), GUCY2C(2), IGF1(1), IGF1R(2), ITPR1(4), ITPR2(6), ITPR3(2), KRAS(2), LYN(1), MAP2K2(1), MAPK1(1), NOS1(7), NOS3(3), NPR2(1), NRAS(1), PLA2G12B(1), PLA2G2D(1), PLA2G4A(1), PLCB1(5), PLCB2(2), PLCB3(2), PLCB4(3), PPP2R1A(2), PPP2R1B(2), PPP2R2A(1), PPP2R2B(1), PPP2R2C(2), PRKCA(1), PRKCG(1), PRKG1(1), PRKG2(1), RYR1(16)	41193234	109	73	107	34	26	30	19	15	19	0	0.0873	1.000	1.000
521	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	129	CD2(1), CD22(1), CD276(1), CD34(1), CD40LG(1), CD58(1), CD86(1), CDH1(1), CDH15(2), CDH3(1), CDH4(3), CDH5(1), CLDN1(2), CLDN10(1), CLDN15(1), CLDN2(2), CLDN20(1), CLDN4(1), CLDN6(1), CLDN8(1), CNTN2(1), CNTNAP1(1), CTLA4(1), F11R(4), GLG1(1), HLA-B(1), HLA-DOA(1), HLA-DOB(1), HLA-DQA2(3), HLA-DRB1(1), HLA-DRB5(1), HLA-E(1), HLA-F(1), ITGA4(2), ITGA6(3), ITGA8(1), ITGA9(1), ITGAL(2), ITGAM(2), ITGAV(3), ITGB2(1), ITGB7(2), ITGB8(1), L1CAM(1), MADCAM1(1), MAG(2), NCAM1(1), NCAM2(2), NEGR1(2), NFASC(1), NLGN1(1), NLGN2(1), NLGN3(1), NRCAM(1), NRXN1(5), NRXN2(2), NRXN3(2), OCLN(1), PTPRC(4), PTPRF(2), PTPRM(6), PVRL2(1), PVRL3(1), SELL(1), SELP(2), SELPLG(1), SIGLEC1(2), SPN(1), VCAM1(1), VCAN(1)	53767564	108	69	108	37	19	29	25	24	11	0	0.247	1.000	1.000
522	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	161	ADORA2A(1), ADORA3(3), ADRA2C(1), AGTR1(2), AGTR2(1), BDKRB1(1), C3AR1(1), CCKAR(1), CCKBR(2), CCR1(2), CCR3(2), CCR4(1), CHML(1), CHRM1(1), CHRM2(2), CHRM4(1), CHRM5(1), CMKLR1(1), CNR1(3), DRD1(1), DRD2(1), DRD3(2), EDNRA(1), F2R(1), F2RL2(1), FSHR(1), GHSR(2), GPR37(2), GPR37L1(1), GPR50(2), GPR63(1), GPR83(3), GRPR(1), HCRTR2(1), HRH3(1), HTR1A(1), HTR1B(1), HTR1D(2), HTR2A(1), HTR4(1), HTR6(1), MC4R(1), MTNR1A(1), NMUR1(1), NMUR2(2), NTSR1(2), NTSR2(1), OPN1SW(1), OPRM1(1), OR10A5(1), OR11A1(2), OR1C1(2), OR1F1(1), OR2H1(2), OR5V1(3), OR7A5(2), OR7C1(1), OR8B8(1), P2RY10(1), P2RY11(1), P2RY12(1), P2RY2(1), P2RY6(1), PTAFR(1), PTGER2(2), PTGIR(1), RGR(1), RHO(1), SSTR3(1), SUCNR1(1), TRHR(1)	42150622	96	66	96	48	15	24	30	16	11	0	0.855	1.000	1.000
523	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	152	CBLB(2), CBLC(1), CCND1(1), CISH(2), CNTFR(1), CREBBP(4), CSF2RA(1), CSF2RB(2), CSF3R(1), EP300(2), EPO(1), IFNA1(1), IFNA14(1), IFNA16(1), IFNA17(1), IFNA6(1), IFNA8(1), IFNAR1(1), IFNG(1), IFNW1(2), IL10RA(2), IL12RB1(1), IL12RB2(3), IL13RA2(1), IL20RA(1), IL21R(1), IL22RA1(1), IL23A(1), IL23R(1), IL26(1), IL2RA(1), IL2RB(5), IL2RG(1), IL5RA(2), IL6R(2), IL7R(1), IL9R(2), IRF9(1), JAK1(1), JAK3(2), LIFR(1), MYC(3), PIAS1(3), PIK3CA(6), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(1), PIK3R3(1), PIM1(1), PRLR(4), PTPN11(3), SOCS2(1), SOS1(2), SPRED1(2), SPRED2(1), SPRY1(1), SPRY3(2), STAT1(2), STAT2(1), STAT3(1), STAT4(1), STAT5A(1), TPO(1), TYK2(1)	53330786	103	64	102	25	14	24	26	24	15	0	0.0914	1.000	1.000
524	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	67	A2M(3), BDKRB1(1), C1QA(1), C1QB(1), C1S(1), C2(1), C3(4), C3AR1(1), C4BPA(2), C4BPB(1), C5(2), C6(6), C7(1), C8A(1), C8B(1), C9(4), CD55(1), CFH(4), CR1(3), CR2(2), F11(3), F12(1), F13A1(3), F13B(1), F2(3), F2R(1), F5(6), F7(1), F8(4), FGA(2), FGB(2), FGG(2), KLKB1(2), KNG1(1), MASP1(3), MASP2(1), MBL2(1), PLG(1), PROS1(1), SERPINA1(1), SERPINA5(1), SERPIND1(1), SERPINF2(1), TFPI(1), VWF(4)	32947310	89	63	89	35	7	28	21	20	12	1	0.803	1.000	1.000
525	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	95	ADCY1(1), ADCY2(3), ADCY3(1), ADCY4(1), ADCY5(1), ADCY7(1), ADCY8(2), ADCY9(1), CACNA1C(4), CACNA1D(2), CACNA1F(5), CACNA1S(6), CAMK2B(1), CAMK2G(1), EGFR(3), GNA11(1), GNAS(2), GNRH2(1), ITPR1(4), ITPR2(6), ITPR3(2), JUN(1), KRAS(2), MAP2K2(1), MAP2K3(2), MAP2K4(2), MAP2K6(2), MAP2K7(3), MAP3K4(1), MAPK1(1), MAPK10(2), MAPK11(1), MAPK7(1), MMP2(2), NRAS(1), PLA2G12B(1), PLA2G2D(1), PLA2G4A(1), PLCB1(5), PLCB2(2), PLCB3(2), PLCB4(3), PLD1(3), PLD2(1), PRKACA(2), PRKACG(1), PRKCA(1), PTK2B(2), SOS1(2)	47890492	98	62	98	38	19	24	16	20	19	0	0.536	1.000	1.000
526	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(2), ABCA10(1), ABCA12(2), ABCA13(11), ABCA2(2), ABCA3(2), ABCA4(2), ABCA5(2), ABCA6(3), ABCA7(2), ABCA8(3), ABCA9(5), ABCB1(1), ABCB11(2), ABCB4(3), ABCB5(6), ABCB6(1), ABCB7(1), ABCC1(1), ABCC10(2), ABCC11(1), ABCC12(4), ABCC2(3), ABCC3(6), ABCC5(1), ABCC6(1), ABCC8(6), ABCC9(1), ABCD1(1), ABCD3(1), ABCD4(1), ABCG1(2), ABCG5(1), CFTR(7)	43801721	90	60	90	35	8	26	22	18	15	1	0.391	1.000	1.000
527	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	108	ABL1(2), ANAPC1(2), ANAPC2(3), ANAPC4(2), ANAPC5(1), ATM(5), ATR(4), BUB1(1), BUB1B(2), CCNA1(1), CCNB3(1), CCND1(1), CCNH(1), CDC20(1), CDC25B(1), CDK2(1), CDK4(1), CDKN1A(2), CDKN2A(2), CDKN2D(1), CHEK2(2), CREBBP(4), CUL1(3), DBF4(2), E2F3(1), EP300(2), ESPL1(3), FZR1(2), MCM3(3), MCM4(1), MCM5(1), MCM7(2), MDM2(1), PKMYT1(1), PRKDC(6), PTTG1(1), SMAD3(2), TFDP1(1), TGFB1(1), WEE1(1), YWHAE(2), YWHAQ(1)	49124197	78	60	77	20	9	17	17	16	19	0	0.276	1.000	1.000
528	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	82	ACVR1(2), ACVR1B(1), AURKB(1), BMPR2(1), BUB1(1), CDIPT(1), CDKL2(1), CDS1(1), CLK1(1), CLK4(1), COL4A3BP(2), DGKB(1), DGKD(3), DGKE(1), DGKG(3), DGKH(2), DGKQ(1), DGKZ(1), INPP1(2), INPP4A(2), INPP4B(1), INPP5A(1), INPPL1(1), ITPKA(1), NEK1(2), OCRL(1), PAK4(1), PIK3C2G(7), PIK3CA(6), PIK3CB(1), PIK3CG(2), PIM2(3), PLCB1(5), PLCB2(2), PLCB3(2), PLCB4(3), PLCG1(1), PLCG2(2), PRKACA(2), PRKACG(1), PRKAR1B(1), PRKAR2B(1), PRKCA(1), PRKCE(2), PRKCG(1), PRKCH(1), PRKCQ(3), PRKD1(1), PRKG1(1), RPS6KA1(1), TGFBR1(1), VRK1(1)	42301178	89	60	87	28	12	21	20	18	18	0	0.421	1.000	1.000
529	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	91	ADCY1(1), ADCY2(3), ADCY3(1), ADCY4(1), ADCY5(1), ADCY7(1), ADCY8(2), ADCY9(1), DRD1(1), DRD2(1), EGFR(3), GJD2(2), GNA11(1), GNAS(2), GRM1(1), GRM5(4), GUCY1A3(1), GUCY1B3(2), GUCY2C(2), HTR2A(1), ITPR1(4), ITPR2(6), ITPR3(2), KRAS(2), MAP2K2(1), MAP2K5(1), MAPK1(1), MAPK7(1), NPR2(1), NRAS(1), PDGFB(1), PDGFD(3), PDGFRA(1), PDGFRB(2), PLCB1(5), PLCB2(2), PLCB3(2), PLCB4(3), PRKACA(2), PRKACG(1), PRKCA(1), PRKCG(1), PRKG1(1), PRKG2(1), SOS1(2), TJP1(1), TUBA3C(3), TUBA3D(1), TUBA3E(1), TUBA4A(1), TUBA8(1), TUBAL3(2), TUBB2B(2), TUBB8(3)	47803069	95	59	94	43	18	27	16	22	12	0	0.804	1.000	1.000
530	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADCY1(1), ADCY2(3), ADCY3(1), ADCY4(1), ADCY5(1), ADCY7(1), ADCY8(2), ADCY9(1), ADK(2), ADSL(1), ADSSL1(1), AK2(1), AK5(3), AK7(1), AMPD1(2), AMPD3(1), APRT(1), ENPP1(3), ENPP3(2), ENTPD1(1), ENTPD3(1), ENTPD8(2), GART(2), GMPR2(1), GMPS(1), GUCY1A3(1), GUCY1B3(2), GUCY2C(2), IMPDH2(1), NME2(1), NME6(2), NPR2(1), NT5E(1), PDE10A(2), PDE11A(1), PDE1A(2), PDE1C(4), PDE2A(1), PDE3B(5), PDE4A(3), PDE4B(1), PDE4C(2), PDE4D(2), PDE5A(1), PDE6H(1), PFAS(1), PKLR(2), PNPT1(2), POLD1(3), POLE(5), POLE2(1), POLE4(1), POLR1A(1), PPAT(1), PRIM2(1), RRM2(1)	60093641	92	58	91	37	8	22	29	12	21	0	0.850	1.000	1.000
531	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AMY2B(4), ASCC3(2), ATP13A2(1), DDX18(2), DDX23(2), DDX4(1), DDX41(1), DDX50(1), DDX51(1), DDX52(1), DDX56(1), ENPP1(3), ENPP3(2), EP400(3), G6PC2(1), GAA(1), GBA(1), GBE1(4), GCK(2), GUSB(2), GYS2(1), HK2(2), IFIH1(1), MGAM(5), MOV10L1(1), PGM1(1), PYGB(2), PYGM(3), RAD54B(1), RAD54L(1), RUVBL2(2), SETX(3), SI(4), SMARCA2(2), SMARCA5(2), TREH(1), UGDH(2), UGP2(2), UGT1A10(1), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT2A3(1), UGT2B11(3), UGT2B15(2), UGT2B17(2)	45735222	85	58	85	22	17	25	17	11	15	0	0.103	1.000	1.000
532	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	75	ACP1(1), ACTB(3), ACTN1(1), ACTN4(3), ACVR1B(1), BAIAP2(3), CDH1(1), CREBBP(4), CTNNA1(2), CTNNA2(5), CTNNA3(3), CTNND1(4), EGFR(3), EP300(2), ERBB2(1), FARP2(2), FER(2), FGFR1(3), FYN(1), IGF1R(2), IQGAP1(4), LMO7(6), MAP3K7(1), MAPK1(1), MET(4), MLLT4(1), PTPN1(1), PTPRB(4), PTPRF(2), PTPRJ(3), PTPRM(6), PVRL2(1), PVRL3(1), RAC1(1), SMAD3(2), SNAI1(2), SORBS1(2), SSX2IP(1), TCF7L1(1), TCF7L2(1), TGFBR1(1), TGFBR2(1), TJP1(1), WASF3(2), YES1(1)	43921628	98	58	98	28	12	32	22	13	19	0	0.153	1.000	1.000
533	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	98	ADCY1(1), ADCY2(3), ADCY3(1), ADCY4(1), ADCY5(1), ADCY7(1), ADCY8(2), ADCY9(1), ASIP(1), CAMK2B(1), CAMK2G(1), CREB3L1(1), CREB3L3(1), CREBBP(4), DCT(3), DVL1(2), DVL2(1), EP300(2), FZD10(1), FZD2(2), FZD3(2), FZD5(1), FZD6(1), GNAO1(1), GNAS(2), KIT(5), KITLG(1), KRAS(2), MAP2K2(1), MAPK1(1), NRAS(1), PLCB1(5), PLCB2(2), PLCB3(2), PLCB4(3), POMC(1), PRKACA(2), PRKACG(1), PRKCA(1), PRKCG(1), TCF7L1(1), TCF7L2(1), TYR(2), WNT10B(1), WNT2(1), WNT2B(1), WNT5A(1), WNT7B(1), WNT8A(1), WNT8B(1)	39618243	78	58	78	32	12	22	13	16	14	1	0.682	1.000	1.000
534	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY1(1), ADCY2(3), ADCY3(1), ADCY4(1), ADCY5(1), ADCY7(1), ADCY8(2), ADCY9(1), AKAP10(1), AKAP11(3), AKAP12(2), AKAP2(2), AKAP3(1), AKAP4(1), AKAP5(1), AKAP6(3), AKAP8(1), AKAP9(2), ARHGEF1(1), GNA11(1), GNAL(1), GNAO1(1), GNAZ(2), GNB2(1), ITPR1(4), KCNJ3(1), KRAS(2), NRAS(1), PDE1A(2), PDE1B(3), PDE1C(4), PDE4A(3), PDE4B(1), PDE4C(2), PDE4D(2), PLCB3(2), PPP3CC(2), PRKACA(2), PRKACG(1), PRKAR1B(1), PRKAR2B(1), PRKCA(1), PRKCE(2), PRKCG(1), PRKCH(1), PRKCI(1), PRKCQ(3), PRKD1(1), PRKD3(2), RRAS(1), SLC9A1(1)	42529061	83	57	83	29	12	18	17	10	25	1	0.603	1.000	1.000
535	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA2(2), ACTN4(3), DMD(9), MYBPC2(1), MYBPC3(3), MYH3(4), MYH6(2), MYH7(7), MYH8(1), NEB(7), TNNT3(1), TTN(45)	50662900	85	53	85	41	15	21	23	8	16	2	0.980	1.000	1.000
536	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	67	ADCY1(1), ADCY8(2), BRAF(1), CACNA1C(4), CAMK2B(1), CAMK2G(1), CREBBP(4), EP300(2), GRIA1(6), GRIN1(2), GRIN2A(3), GRIN2D(2), GRM1(1), GRM5(4), ITPR1(4), ITPR2(6), ITPR3(2), KRAS(2), MAP2K2(1), MAPK1(1), NRAS(1), PLCB1(5), PLCB2(2), PLCB3(2), PLCB4(3), PPP1R12A(2), PPP1R1A(2), PPP3CB(1), PPP3CC(2), PRKACA(2), PRKACG(1), PRKCA(1), PRKCG(1), RAP1A(1), RPS6KA1(1)	37267657	77	52	77	26	14	18	12	20	13	0	0.340	1.000	1.000
537	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	80	ABL1(2), ATM(5), BUB1(1), BUB1B(2), CCNA1(1), CCNB3(1), CCNH(1), CDC20(1), CDC25B(1), CDH1(1), CDK2(1), CDK4(1), CDKN1A(2), CDKN2A(2), CHEK2(2), DTX4(2), E2F3(1), E2F4(2), E2F5(1), E2F6(1), EP300(2), ESPL1(3), HDAC3(1), HDAC4(1), HDAC5(3), HDAC6(2), MCM3(3), MCM4(1), MCM5(1), MCM7(2), MDM2(1), MPEG1(1), PRKDC(6), PTPRA(2), PTTG1(1), TFDP1(1), TGFB1(1), WEE1(1)	39713470	64	49	64	20	7	13	19	11	14	0	0.511	1.000	1.000
538	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	108	ALG1(1), ALG11(2), ALG13(1), ALG14(1), ALG2(1), ALG3(1), ALG6(1), ALG9(1), B3GNT2(2), B4GALT5(2), CHPF(1), CHST1(2), CHST11(1), CHST14(1), CHST3(1), CHST4(1), EXT1(1), EXTL2(1), EXTL3(2), FUT11(1), FUT8(1), GALNT10(1), GALNT13(1), GALNT14(3), GALNT3(1), GALNT5(1), GALNT7(1), GALNT8(3), GALNT9(1), GALNTL5(1), GANAB(1), HS3ST1(1), HS3ST3A1(1), HS3ST3B1(1), HS3ST5(2), HS6ST1(2), MAN1A1(3), MAN1B1(1), MAN1C1(2), MGAT3(1), MGAT5(2), MGAT5B(2), NDST3(4), NDST4(3), OGT(1), RPN2(2), ST6GALNAC1(1), WBSCR17(3), XYLT1(1), XYLT2(2)	40330126	75	47	74	33	9	29	17	10	9	1	0.660	1.000	1.000
539	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	BCR(2), BLNK(2), BTK(1), CD19(1), CD22(1), CD81(1), CR2(2), INPP5D(3), ITPR1(4), ITPR2(6), ITPR3(2), LYN(1), MAP4K1(3), MAPK1(1), NFATC2(2), PIK3CA(6), PIK3CD(1), PIK3R1(1), PLCG2(2), PPP1R13B(1), PPP3CB(1), PPP3CC(2), PTPRC(4), SOS1(2), SYK(2), VAV1(3)	26928115	57	47	56	20	12	7	18	8	12	0	0.617	1.000	1.000
540	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	71	ACACB(4), ACSL3(1), ACSL4(2), ACSL6(4), ADIPOR1(1), CAMKK1(2), CPT1A(1), CPT1B(1), G6PC2(1), IRS1(1), IRS4(3), JAK1(1), JAK3(2), MAPK10(2), NFKB1(1), POMC(1), PPARA(1), PPARGC1A(1), PRKAA2(5), PRKAB2(1), PRKCQ(3), PTPN11(3), RELA(2), RXRA(1), RXRG(1), SLC2A4(1), STAT3(1), TNF(1), TNFRSF1A(1), TRADD(1), TRAF2(2), TYK2(1)	30474872	54	45	54	22	13	11	14	12	4	0	0.691	1.000	1.000
541	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADCY1(1), ADCY2(3), ADCY3(1), ADCY4(1), ADCY5(1), ADCY7(1), ADCY8(2), ADK(2), ADSL(1), AK2(1), AK5(3), AMPD1(2), AMPD3(1), APRT(1), ATP5B(1), ATP5C1(1), ATP5J2(1), ENPP1(3), ENPP3(2), ENTPD1(1), GART(2), GMPS(1), GUCY1A3(1), GUCY1B3(2), GUCY2C(2), IMPDH2(1), NME2(1), NPR2(1), NT5E(1), PDE1A(2), PDE4A(3), PDE4B(1), PDE4C(2), PDE4D(2), PDE5A(1), PDE6B(3), PDE6C(1), PFAS(1), PKLR(2), POLD1(3), POLE(5), POLG(1), POLL(1), POLQ(7), POLRMT(1), PPAT(1), RRM2(1)	47120757	80	45	79	28	9	23	30	6	12	0	0.500	1.000	1.000
542	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	57	ASH1L(3), CARM1(1), CTCFL(2), DOT1L(1), EED(1), EHMT1(1), EHMT2(1), HCFC1(5), HSF4(1), MEN1(2), NSD1(1), OGT(1), PAXIP1(6), PRDM2(3), PRDM6(1), PRDM7(1), PRDM9(4), PRMT1(1), PRMT6(1), PRMT8(1), SATB1(3), SETD1A(4), SETD1B(4), SETD2(2), SETD8(1), SMYD3(1), SUV39H1(1), SUZ12(2), WHSC1(3)	45830407	59	43	59	20	6	20	10	5	18	0	0.694	1.000	1.000
543	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	63	ATM(5), CCNA1(1), CCND1(1), CCNH(1), CDK2(1), CDK4(1), CDKN1A(2), CDKN2A(2), CDKN2D(1), CREB3L1(1), CREB3L3(1), E2F3(1), E2F4(2), E2F5(1), E2F6(1), GBA2(3), MCM3(3), MCM4(1), MCM5(1), MCM7(2), MDM2(1), MYC(3), MYT1(3), NACA(2), POLE(5), POLE2(1), RPA1(1), TFDP1(1), TFDP2(1), TNXB(6), WEE1(1)	27175636	57	43	57	18	9	15	14	11	8	0	0.361	1.000	1.000
544	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	66	ATP6AP1(2), ATP6V0A4(1), ATP6V1A(2), ATP6V1E1(1), EGFR(3), F11R(4), JUN(1), LYN(1), MAP2K4(2), MAPK10(2), MAPK11(1), MET(4), NFKB1(1), NOD1(3), PAK1(1), PLCG1(1), PLCG2(2), PTPN11(3), PTPRZ1(6), RAC1(1), RELA(2), TCIRG1(1), TJP1(1)	25724130	46	38	46	16	7	13	10	7	9	0	0.504	1.000	1.000
545	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ADCY4(1), ADCY8(2), CACNA1A(7), CACNA1B(7), GNAS(2), GRM4(1), ITPR3(2), KCNB1(1), PDE1A(2), PLCB2(2), PRKACA(2), PRKACG(1), SCNN1A(1), SCNN1B(1), SCNN1G(3), TAS1R1(2), TAS1R2(1), TAS1R3(1), TAS2R38(1), TAS2R39(1), TAS2R40(1), TAS2R5(1), TAS2R7(1), TAS2R9(1), TRPM5(6)	21272706	51	37	50	24	12	10	12	8	9	0	0.644	1.000	1.000
546	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	51	BAG4(1), CASP2(1), CASP8(1), DAXX(1), LMNB1(1), MAP2K7(3), MAP3K5(4), MDM2(1), NFKB1(1), NUMA1(2), PRKDC(6), PSEN2(1), PTK2(3), RASA1(3), RELA(2), RIPK1(2), SPTAN1(4), TNF(1), TNFRSF1A(1), TRADD(1), TRAF2(2)	24872964	42	34	42	13	5	15	8	3	11	0	0.464	1.000	1.000
547	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CDC40(1), CLK4(1), COL2A1(1), CPSF1(1), CPSF3(1), CSTF2(1), DDX1(1), DHX15(1), DHX38(2), DHX8(3), DICER1(3), DNAJC8(1), NUDT21(2), NXF1(1), PABPN1(1), PAPOLA(1), PRPF18(1), PRPF4B(1), PRPF8(4), PTBP1(1), RBM17(1), RNMT(1), SF3A1(1), SF3A2(1), SF3A3(1), SF3B1(3), SF3B2(1), SNRPB2(1), SNRPE(1), SRPK1(2), SRPK2(2), SRRM1(3), SUPT5H(2), U2AF2(1)	38695611	50	34	50	13	3	14	11	9	13	0	0.374	1.000	1.000
548	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACADL(1), ACOX2(1), ACSL3(1), ACSL4(2), ACSL6(4), ANGPTL4(1), APOA5(1), CPT1A(1), CPT1B(1), CYP27A1(1), CYP4A11(1), CYP8B1(1), FABP4(1), FABP6(1), FABP7(1), FADS2(1), GK2(2), HMGCS2(2), LPL(2), ME1(1), MMP1(2), PLTP(1), PPARA(1), RXRA(1), RXRG(1), SCD(1), SLC27A4(1), SLC27A5(1), SLC27A6(1), SORBS1(2)	23750730	39	33	39	23	7	7	10	8	7	0	0.985	1.000	1.000
549	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	CHRM1(1), FLT1(3), FLT4(2), KDR(4), NOS3(3), PDE2A(1), PDE3A(1), PDE3B(5), PRKACG(1), PRKAR1B(1), PRKAR2B(1), PRKG1(1), PRKG2(1), RYR2(16), SYT1(2)	15168083	43	33	43	16	3	11	8	13	8	0	0.607	1.000	1.000
550	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(1), AKR1D1(2), ARSE(1), CARM1(1), CYP11B1(3), CYP11B2(1), CYP19A1(1), HEMK1(1), HSD11B1(1), HSD17B1(1), HSD17B12(2), HSD17B2(1), HSD3B1(1), HSD3B2(1), PRMT2(2), PRMT3(1), PRMT6(1), PRMT8(1), STS(1), SULT1E1(1), SULT2A1(1), UGT1A10(1), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT2A3(1), UGT2B11(3), UGT2B15(2), UGT2B17(2), WBSCR22(1)	18265347	40	32	40	17	7	7	5	11	10	0	0.884	1.000	1.000
551	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	BCR(2), BLNK(2), BTK(1), CD19(1), EPHB2(1), ITPKA(1), LYN(1), MAP2K2(1), MAPK1(1), NFAT5(4), NFKB1(1), NFKBIL1(1), PI3(1), PIK3CA(6), PIK3CD(1), PIK3R1(1), PLCG2(2), PPP1R13B(1), SERPINA4(1), SOS1(2), SYK(2), VAV1(3)	19502623	37	32	36	15	8	4	9	7	9	0	0.826	1.000	1.000
552	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	CAD(4), DPYD(6), DTYMK(1), ENTPD1(1), ENTPD3(1), ENTPD8(2), NME2(1), NME6(2), NT5E(1), PNPT1(2), POLD1(3), POLE(5), POLE2(1), POLE4(1), POLR1A(1), PRIM2(1), RRM2(1), TXNRD1(4), TXNRD2(2), UMPS(1), UPP2(1)	29929462	42	31	41	14	2	11	10	7	12	0	0.711	1.000	1.000
553	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(2), AASDHPPT(1), AASS(1), ACAT1(2), AKR1B10(1), ALDH1A3(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), BBOX1(2), DOT1L(1), EHMT1(1), EHMT2(1), HADHA(1), HSD17B4(1), NSD1(1), OGDHL(4), PLOD2(2), PLOD3(1), SETD1A(4), SUV39H1(1), TMLHE(1)	21122637	33	31	33	15	2	7	9	6	9	0	0.872	1.000	1.000
554	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AADAT(2), ACAT1(2), ALDH1A3(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), AOC3(1), AOX1(2), CARM1(1), CYP1A2(2), DDC(2), HADHA(1), HEMK1(1), HSD17B4(1), INMT(1), KYNU(2), LNX1(1), MAOB(1), OGDHL(4), PRMT2(2), PRMT3(1), PRMT6(1), PRMT8(1), TPH2(3), WARS(1), WARS2(1), WBSCR22(1)	22212882	40	31	40	15	7	12	5	8	8	0	0.634	1.000	1.000
555	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CTLA4(1), DTYMK(1), EPHB2(1), GRAP2(2), ITK(1), ITPKA(1), LAT(1), LCK(1), LCP2(2), MAPK1(1), NFAT5(4), NFKB1(1), NFKBIL1(1), PAK1(1), PAK3(3), PAK4(1), PAK7(1), PLCG1(1), PTPRC(4), SOS1(2), VAV1(3), ZAP70(5)	20858987	39	31	39	13	7	13	7	7	5	0	0.452	1.000	1.000
556	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	ACAT1(2), ALDH1A2(1), ALDH1A3(2), ALDH2(1), ALDH9A1(1), AOC3(1), AOX1(2), CYP19A1(1), CYP1A2(2), CYP2A13(1), CYP2C18(3), CYP2C19(2), CYP2C9(2), CYP2E1(3), CYP2F1(2), CYP2J2(2), CYP3A4(3), CYP3A7(2), CYP4B1(1), DDC(2), HADHA(1), KYNU(2), MAOB(1), WARS(1), WARS2(1)	20264018	42	31	42	17	8	11	8	9	6	0	0.604	1.000	1.000
557	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(5), AXIN1(1), CCND1(1), DVL1(2), DVL2(1), FZD10(1), FZD2(2), FZD3(2), FZD5(1), FZD6(1), JUN(1), MAPK10(2), MYC(3), PPP2R5C(2), PPP2R5E(1), PRKCA(1), PRKCE(2), PRKCG(1), PRKCH(1), PRKCI(1), PRKCQ(3), PRKD1(1), RAC1(1), SFRP4(1), WNT10B(1), WNT2(1), WNT2B(1), WNT5A(1), WNT7B(1)	21607923	43	30	43	16	7	10	6	5	15	0	0.528	1.000	1.000
558	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	66	BNIP3L(1), CASP2(1), CASP4(2), CASP8(1), FAS(1), HELLS(1), IRF2(1), IRF3(1), IRF5(1), IRF6(1), JUN(1), MAP2K4(2), MAPK10(2), MDM2(1), MYC(3), NFKB1(1), PLEKHG5(3), RELA(2), RIPK1(2), TNF(1), TNFRSF10B(1), TNFRSF1A(1), TNFRSF21(3), TNFSF10(1), TRADD(1), TRAF2(2)	20685880	38	29	38	14	6	11	5	5	11	0	0.657	1.000	1.000
559	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F11(3), F12(1), F13B(1), F2(3), F5(6), F7(1), F8(4), FGA(2), FGB(2), FGG(2), PLG(1), SERPINF2(1), VWF(4)	12690612	31	29	31	18	2	9	8	7	4	1	0.984	1.000	1.000
560	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	50	AKR1C3(1), ALOX12(2), ALOX12B(4), ALOX15(1), ALOX5(2), CBR3(1), CYP2C18(3), CYP2C19(2), CYP2C9(2), CYP2E1(3), CYP2J2(2), CYP4A11(1), CYP4F2(2), GGT1(1), GPX5(2), PLA2G12B(1), PLA2G2D(1), PLA2G4A(1), PTGIS(1), PTGS1(1), PTGS2(1), TBXAS1(1)	14765817	36	29	36	12	6	7	14	3	6	0	0.476	1.000	1.000
561	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	48	CDKN2A(2), F2RL2(1), INPPL1(1), IRS1(1), IRS4(3), LNPEP(3), MAPK1(1), PIK3CA(6), PIK3CD(1), PIK3R1(1), PTPN1(1), RPS6KA1(1), SERPINB6(1), SLC2A4(1), SORBS1(2), SOS1(2), YWHAE(2), YWHAQ(1)	21026557	31	28	29	13	1	5	10	6	9	0	0.911	1.000	1.000
562	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	21	ATM(5), ATR(4), BRCA1(2), CDC25B(1), CDKN1A(2), CDKN2D(1), CHEK2(2), EP300(2), MDM2(1), MYT1(3), PRKDC(6), RPS6KA1(1), WEE1(1), YWHAQ(1)	15361135	32	26	32	13	1	10	6	7	8	0	0.825	1.000	1.000
563	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG2(1), ANGPTL2(2), FLNA(4), FLNC(3), FSCN3(1), GDI1(1), LIMK1(3), MYH2(6), MYLK(3), MYLK2(2), PAK1(1), PAK3(3), PAK4(1), PAK7(1), PFN2(1), RHO(1), ROCK1(1), ROCK2(2), VASP(1)	17633746	38	26	38	16	5	11	13	5	4	0	0.729	1.000	1.000
564	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	31	ANKRD6(1), APC(5), AXIN1(1), AXIN2(2), DACT1(1), DKK2(1), DVL1(2), FSTL1(2), LRP1(4), MVP(1), NKD2(2), PIN1(1), PTPRA(2), WIF1(4)	14984319	29	26	29	14	5	5	5	3	11	0	0.846	1.000	1.000
565	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	AGMAT(1), ALDH1A2(1), ALDH1A3(2), ALDH2(1), ALDH9A1(1), AMD1(1), AOC3(1), ARG2(2), ASL(1), CKMT2(1), MAOB(1), NOS1(7), NOS3(3), P4HA2(1), P4HA3(1), PYCR1(2), RARS(2)	16324615	29	25	29	11	5	8	8	2	6	0	0.533	1.000	1.000
566	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	AGXT(1), AGXT2(1), ALAS1(1), ALAS2(3), AOC3(1), CBS(1), CHDH(1), CPT1B(1), CTH(1), DMGDH(1), MAOB(1), PLCB2(2), PLCG1(1), PLCG2(2), PSPH(1), SARDH(3), SARS(2), TARS(3)	15728079	27	25	27	12	2	8	8	7	2	0	0.733	1.000	1.000
567	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	B3GNT2(2), B4GALNT1(4), FUT1(3), FUT2(1), FUT5(1), FUT9(3), PIGB(1), PIGC(2), PIGG(2), PIGN(3), PIGS(2), PIGT(1), ST3GAL5(1), ST6GALNAC3(1), ST6GALNAC5(1), ST6GALNAC6(1)	17864285	29	25	29	11	6	10	6	4	3	0	0.465	1.000	1.000
568	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	65	AGTR1(2), AGTR2(1), ATP8A1(4), BDKRB1(1), C3AR1(1), CCKAR(1), CCKBR(2), CCR1(2), CCR3(2), CCR4(1), CXCR6(2), EDNRA(1), FSHR(1), GHSR(2), GRPR(1), MC4R(1), NTSR1(2), NTSR2(1), OPRM1(1), SSTR3(1), TACR1(2), TRHR(1)	17823780	33	25	33	21	5	8	8	4	8	0	0.961	1.000	1.000
569	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(1), ACPP(1), ALPI(1), ALPL(3), ALPP(1), CYP19A1(1), CYP1A2(2), CYP2A13(1), CYP2C18(3), CYP2C19(2), CYP2C9(2), CYP2E1(3), CYP2F1(2), CYP2J2(2), CYP3A4(3), CYP3A7(2), CYP4B1(1)	10839534	31	23	31	12	4	9	9	4	5	0	0.464	1.000	1.000
570	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(4), C5(2), C6(6), C7(1), IL1A(1), ITGA4(2), ITGAL(2), ITGB2(1), SELP(2), SELPLG(1), TNF(1), VCAM1(1)	9068561	24	23	24	10	4	3	7	8	2	0	0.711	1.000	1.000
571	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	39	ALK(3), ESR2(2), ESRRA(1), HNF4A(2), NR0B1(2), NR1D1(1), NR1D2(1), NR1I3(1), NR2E1(1), NR4A1(1), PPARA(1), RARA(1), RARB(4), RORC(1), RXRA(1), RXRG(1), THRA(1)	14643136	25	23	25	12	4	5	6	3	7	0	0.877	1.000	1.000
572	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(3), DGKI(1), MRPL19(1), RPL11(1), RPL13A(1), RPL14(2), RPL17(1), RPL36(1), RPL4(1), RPL41(1), RPL5(3), RPL7(1), RPS20(1), RPS23(1), RPS26(1), RPS6(1), RPS6KA1(1), RPS7(1), SLC36A2(2), UBB(2)	19504484	27	23	26	11	3	9	7	2	6	0	0.746	1.000	1.000
573	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS2(2), ABAT(1), ADSL(1), ADSSL1(1), AGXT(1), AGXT2(1), ASL(1), ASNS(1), ASPA(1), ASRGL1(1), CAD(4), DARS(1), DLAT(1), GAD1(1), GAD2(2), GPT2(2), PC(1), PDHA2(2), PDHB(1)	13886257	26	22	26	10	2	9	6	3	6	0	0.587	1.000	1.000
574	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ARG2(2), ASL(1), CKMT2(1), EPRS(2), LAP3(2), NOS1(7), NOS3(3), P4HA2(1), P4HA3(1), PRODH(2), PYCR1(2), RARS(2)	13389358	26	22	26	10	6	9	7	0	4	0	0.443	1.000	1.000
575	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ALDH1A3(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), AOC3(1), ASPA(1), CARM1(1), DDC(2), FTCD(2), HARS2(1), HDC(3), HEMK1(1), MAOB(1), PRMT2(2), PRMT3(1), PRMT6(1), PRMT8(1), UROC1(2), WBSCR22(1)	14717888	26	22	26	15	7	6	5	4	4	0	0.951	1.000	1.000
576	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSE(1), CERK(1), GAL3ST1(1), GALC(3), GBA(1), GLA(1), LCT(5), NEU3(2), PPAP2A(1), PPAP2B(2), PPAP2C(1), SGMS1(1), SGPP1(2), SMPD2(2), SMPD3(2), SMPD4(1), SPHK2(2), SPTLC1(1), UGT8(2)	13093874	32	22	31	14	4	6	7	3	11	1	0.860	1.000	1.000
577	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(1), ABAT(1), ACAT1(2), AKR1B10(1), ALDH1A3(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), BDH2(2), GAD1(1), GAD2(2), HADHA(1), HMGCS2(2), HSD17B4(1), ILVBL(1), OXCT2(1), PDHA2(2), PDHB(1), PLA1A(2)	14944155	26	22	26	12	3	6	8	5	4	0	0.797	1.000	1.000
578	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	AGXT(1), AGXT2(1), AKR1B10(1), ALAS1(1), ALAS2(3), AOC3(1), CBS(1), CHDH(1), CTH(1), DMGDH(1), MAOB(1), PSPH(1), SARDH(3), SARS(2), TARS(3), TARS2(2)	16138840	24	21	24	10	2	7	8	5	2	0	0.618	1.000	1.000
579	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	DLG4(1), GRIN1(2), GRIN2A(3), GRIN2D(2), NOS1(7), PPP3CB(1), PPP3CC(2), PRKACG(1), PRKAR1B(1), PRKAR2B(1), PRKCA(1), SYT1(2)	9237365	24	21	24	10	4	6	8	2	4	0	0.697	1.000	1.000
580	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	BCR(2), BLNK(2), JUN(1), LYN(1), MAPK1(1), MAPK8IP3(3), PAPPA(6), RAC1(1), RPS6KA1(1), SOS1(2), SYK(2), VAV1(3), VAV2(3), VAV3(1)	11934491	29	21	29	11	5	6	7	4	7	0	0.582	1.000	1.000
581	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(1), ALOX15(1), ALOX5(2), CYP1A2(2), CYP2C18(3), CYP2C19(2), CYP2C9(2), CYP2E1(3), CYP2J2(2), CYP3A4(3), CYP3A7(2), PLA2G12B(1), PLA2G2D(1), PLA2G4A(1)	8979329	26	20	26	11	5	6	7	4	4	0	0.619	1.000	1.000
582	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(1), AKR1D1(2), ARSE(1), CYP11B1(3), CYP11B2(1), HSD11B1(1), HSD17B2(1), HSD3B1(1), HSD3B2(1), STS(1), SULT1E1(1), SULT2A1(1), UGT1A10(1), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT2B15(2)	9915105	22	19	22	13	4	1	3	7	7	0	0.975	1.000	1.000
583	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(1), CAD(4), EARS2(1), EPRS(2), GAD1(1), GAD2(2), GCLC(1), GLS2(1), GLUL(2), GMPS(1), GPT2(2), PPAT(1), QARS(1)	14348556	20	17	20	12	4	2	7	3	4	0	0.963	1.000	1.000
584	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(1), EXTL2(1), EXTL3(2), GLCE(2), HS3ST1(1), HS3ST3A1(1), HS3ST3B1(1), HS3ST5(2), HS6ST1(2), NDST3(4), NDST4(3)	7627157	20	17	19	10	3	6	4	4	3	0	0.833	1.000	1.000
585	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(1), CAMK2B(1), CAMK2G(1), CLCA1(1), CLCA2(1), CNGA3(4), CNGB1(1), GNAL(1), GUCA1C(1), PDE1C(4), PRKACA(2), PRKACG(1), PRKG1(1), PRKG2(1)	11147247	21	17	21	10	2	5	6	4	4	0	0.797	1.000	1.000
586	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	DUSP1(1), MAP2K3(2), MAP2K4(2), MAP2K6(2), MAP3K4(1), MAP3K5(4), MAP3K7(1), MAPK1(1), MAPK11(1), MKNK1(1), NFKB1(1), SRF(1), TRAF6(2)	12481785	20	17	20	11	2	4	5	6	2	1	0.921	1.000	1.000
587	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(1), CAD(4), EPRS(2), GAD1(1), GAD2(2), GCLC(1), GLS2(1), GLUL(2), GMPS(1), GPT2(2), PPAT(1), QARS(1)	12030926	19	16	19	12	4	2	6	3	4	0	0.974	1.000	1.000
588	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B4GALT5(2), GALNT10(1), GALNT13(1), GALNT14(3), GALNT3(1), GALNT5(1), GALNT7(1), GALNT8(3), GALNT9(1), GALNTL5(1), OGT(1), ST6GALNAC1(1), WBSCR17(3)	11775073	20	14	20	10	3	10	4	1	2	0	0.666	1.000	1.000
589	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ALDH1A2(1), ALDH1A3(2), ALDH2(1), ALDH9A1(1), AOC3(1), ASPA(1), DDC(2), HDC(3), MAOB(1)	8973023	13	12	13	10	5	2	2	3	1	0	0.972	1.000	1.000
590	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	CDKN1A(2), EPO(1), GRIN1(2), HIF1A(1), NFKB1(1), RELA(2)	4676614	9	9	9	5	2	3	2	2	0	0	0.843	1.000	1.000
591	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	13	DUSP1(1), IKBKAP(2), NFKB1(1), RELA(2), TRAF6(2)	6746232	8	7	8	4	1	3	2	2	0	0	0.791	1.000	1.000
592	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	HS3ST1(1), HS3ST3A1(1), HS3ST3B1(1), XYLT1(1), XYLT2(2)	2478737	6	6	6	4	1	2	1	2	0	0	0.841	1.000	1.000
593	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	HS3ST1(1), HS3ST3A1(1), HS3ST3B1(1), XYLT1(1), XYLT2(2)	2478737	6	6	6	4	1	2	1	2	0	0	0.841	1.000	1.000
594	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	ITGA4(2), ITGAL(2), ITGB2(1), SELL(1)	4506207	6	6	6	4	2	0	2	2	0	0	0.901	1.000	1.000
595	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(1), GAD1(1), HDC(3), TH(1)	2204291	6	6	6	4	2	3	0	1	0	0	0.833	1.000	1.000
596	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	IL2RG(1), IRS1(1), JAK1(1), JAK3(2)	5439985	5	5	5	3	1	0	3	1	0	0	0.878	1.000	1.000
597	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	CD3G(1), ITGAL(2), ITGB2(1)	3137330	4	4	4	4	1	0	2	1	0	0	0.962	1.000	1.000
598	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	FADS2(1), PLA2G12B(1), PLA2G2D(1), PLA2G4A(1)	3919090	4	4	4	5	1	2	1	0	0	0	0.981	1.000	1.000
599	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	GREB1(2), HSPB2(1), PDZK1(1), TUBA8(1)	4154701	5	4	5	4	2	0	0	3	0	0	0.889	1.000	1.000
600	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	8	EIF2S2(1), NFKB1(1), RELA(2)	3362743	4	4	4	3	2	2	0	0	0	0	0.908	1.000	1.000
601	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	HMGB1(1), TOP2A(1), TOP2B(1)	3873946	3	3	3	3	0	0	1	2	0	0	0.979	1.000	1.000
602	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(2), PGLYRP2(1)	634153	3	3	3	3	2	0	1	0	0	0	0.959	1.000	1.000
603	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA2(1), JAK1(1), TYK2(1)	3868047	3	3	3	4	0	1	1	1	0	0	0.987	1.000	1.000
604	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA2(1), JAK1(1), TYK2(1)	3868047	3	3	3	4	0	1	1	1	0	0	0.987	1.000	1.000
605	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	PRODH(2)	2141785	2	2	2	2	1	1	0	0	0	0	0.873	1.000	1.000
606	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(1), BMPR2(1)	2218155	2	2	2	3	0	2	0	0	0	0	0.956	1.000	1.000
607	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	HLA-DRB1(1)	1428643	1	1	1	2	1	0	0	0	0	0	0.945	1.000	1.000
608	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(1)	1151471	1	1	1	2	0	0	0	1	0	0	0.981	1.000	1.000
609	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(1)	799416	1	1	1	3	0	0	1	0	0	0	0.991	1.000	1.000
610	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	19	CASP8(1)	4958152	1	1	1	2	0	0	1	0	0	0	0.985	1.000	1.000
611	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2		582152	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
612	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1		259063	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
613	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		185349	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
614	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3		812817	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
615	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4		1110624	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
616	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2		545786	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
