rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(11)	311023	11	11	11	0	3	2	1	1	4	0	0.0397	0.000216	0.133
2	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(1), DCN(8), FMOD(10), KERA(1), LUM(7)	1561475	27	24	27	4	12	4	1	7	3	0	0.0696	0.310	1.000
3	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(3), LIPT1(5)	652455	8	8	7	1	2	3	0	0	3	0	0.274	0.449	1.000
4	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(8), GSTZ1(3), HGD(4)	953469	15	13	14	3	4	3	0	4	4	0	0.377	0.460	1.000
5	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	3	CD28(1), HLA-DRA(8)	632681	9	9	9	2	4	3	0	0	2	0	0.414	0.533	1.000
6	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(6), TPI1(1)	706305	7	7	7	1	2	2	1	1	1	0	0.308	0.600	1.000
7	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	CDK5(2), FOSB(5), GRIA2(23), JUND(2), PPP1R1B(1)	1603188	33	27	33	6	7	10	1	9	6	0	0.0641	0.630	1.000
8	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(6), ALDOA(1), ALDOB(6), ALDOC(6), TPI1(1)	1682865	20	20	20	3	3	7	1	6	3	0	0.117	0.640	1.000
9	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3E(2), CD3G(1)	488715	3	3	3	1	0	1	1	0	1	0	0.822	0.702	1.000
10	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	7	CD28(1), CD80(4), HLA-DRA(8), IL10(2), IL4(1)	1318652	16	16	16	3	8	3	0	2	3	0	0.214	0.706	1.000
11	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCL11(1), CCL5(2), CCR3(6), HLA-DRA(8), IL3(1)	1308153	18	16	18	4	9	6	0	2	1	0	0.154	0.711	1.000
12	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(5), CDK2(3), CUL1(22), E2F1(3), RB1(13), RBX1(1), SKP2(5), TFDP1(5), UBE2M(1)	3687047	58	41	56	10	10	21	2	8	17	0	0.0122	0.844	1.000
13	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(10), GLS2(7), GLUD1(2), GLUD2(11)	1951070	30	23	29	5	7	8	0	11	4	0	0.0797	0.857	1.000
14	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(2), SEC61A2(1), SRP19(4), SRP54(6), SRP68(5), SRP72(10), SRP9(1), SRPR(12)	3233319	41	31	41	5	12	12	1	5	11	0	0.0223	0.866	1.000
15	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	7	CCNE1(5), CDC34(2), CDK2(3), CUL1(22), E2F1(3), RB1(13), TFDP1(5)	2829330	53	39	51	10	12	17	2	8	14	0	0.0211	0.880	1.000
16	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	18	ABCB1(26), AKT1(3), ATM(38), BAX(6), CDKN1A(3), CPB2(10), CSNK1A1(3), CSNK1D(2), FHL2(4), HIC1(6), HIF1A(7), HSPA1A(2), IGFBP3(6), MAPK8(5), MDM2(5), NFKBIB(6), NQO1(3)	8554171	135	74	123	27	30	30	4	22	44	5	0.0262	0.915	1.000
17	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(2), FDPS(9), IDI1(2), SQLE(5)	1363502	18	13	17	3	4	4	1	3	6	0	0.191	0.918	1.000
18	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	5	CCR5(4), CD28(1), CD3E(2), CD3G(1)	992068	8	8	8	2	0	4	1	0	3	0	0.626	0.940	1.000
19	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	AOC2(6), AOC3(15), CES1(7), ESD(1)	2594728	29	25	22	6	7	4	0	7	10	1	0.516	0.946	1.000
20	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	14	CD8A(4), CSF1(2), CSF3(2), EPO(1), IL11(3), IL3(1), IL4(1), IL7(1)	2220344	15	15	15	1	5	4	1	2	3	0	0.0446	0.952	1.000
21	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	ASRGL1(2), GBA(9), GGT1(6), SHMT1(2), SHMT2(9)	2348712	28	25	26	5	11	3	1	3	10	0	0.112	0.961	1.000
22	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(5), SUCLA2(4)	907276	9	9	9	2	5	0	0	2	2	0	0.459	0.961	1.000
23	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(4), ADH1B(4), ADH4(2), ADH6(7), ADH7(1), ADHFE1(9)	2419403	27	21	26	6	2	7	0	11	6	1	0.300	0.967	1.000
24	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(3), LPL(7), NR3C1(6), PPARG(4), RXRA(6), TNF(3)	2484079	29	27	27	7	7	2	4	8	8	0	0.344	0.974	1.000
25	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALE(1), GALT(1), TGDS(4), UGDH(5), UXS1(5)	1650101	16	14	16	3	5	6	1	2	2	0	0.143	0.975	1.000
26	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALE(1), GALT(1), TGDS(4), UGDH(5), UGP2(7), UXS1(5)	2102519	23	19	21	4	6	6	1	3	7	0	0.146	0.978	1.000
27	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CASP3(2), CD36(2), FOS(1), FYN(10), JUN(4), MAPK14(1), THBS1(16)	3182545	36	29	35	7	10	11	1	8	5	1	0.0773	0.978	1.000
28	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(5), ACAT2(4), ACYP1(1), ACYP2(3), EHHADH(7), GCDH(8), HADHA(4), SDHB(4), SDS(4)	3350753	40	29	37	7	9	14	2	3	11	1	0.0439	0.979	1.000
29	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(5), CCL2(1), CSF1(2), LDLR(10), LPL(7)	2287815	25	23	25	7	9	4	1	4	6	1	0.230	0.982	1.000
30	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(5), SLPI(3)	735928	8	7	7	4	3	1	0	1	3	0	0.869	0.983	1.000
31	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	12	CD2(3), CD34(4), CD3E(2), CD3G(1), CD58(6), CD8A(4), CSF3(2), IL3(1), KITLG(3)	2261536	26	20	25	6	3	8	2	3	10	0	0.226	0.984	1.000
32	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(3), BCKDK(8), CBS(6), CTH(2), MUT(6)	2096137	25	22	24	9	5	4	1	2	12	1	0.790	0.987	1.000
33	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	9	CCL11(1), CCR3(6), HLA-DRA(8), IL1B(3), IL4(1), IL5RA(4)	1905414	23	19	23	6	9	6	0	3	5	0	0.241	0.988	1.000
34	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(4), IFNG(2), IL12A(2), IL12B(2), IL18(1)	1274062	11	10	10	4	1	3	1	4	2	0	0.816	0.989	1.000
35	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(2), FDPS(9), GGPS1(1), IDI1(2), IDI2(1), SQLE(5)	1827582	20	14	19	4	4	5	1	3	7	0	0.286	0.991	1.000
36	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	13	AKT1(3), BAD(3), CASP9(3), CHUK(4), GH1(2), GHR(6), NFKB1(7), NFKBIA(1), PDPK1(2), PIK3R1(11), PPP2CA(4), RELA(5), YWHAH(3)	5104423	54	35	53	9	10	15	3	12	13	1	0.0343	0.993	1.000
37	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GGT1(6), SHMT1(2), SHMT2(9)	1767088	17	17	15	5	7	0	0	1	9	0	0.515	0.996	1.000
38	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(6), ERBB4(48), NRG2(8), NRG3(17), PRKCA(5), PSEN1(3)	3865364	87	60	81	23	21	22	8	20	16	0	0.177	0.996	1.000
39	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	8	CCNB1(3), CDC25A(6), CDC25B(4), CSK(7), GRB2(4), PRKCA(5), PTPRA(12), SRC(3)	3538332	44	36	44	9	14	13	0	6	11	0	0.0559	0.996	1.000
40	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(5), ACAT2(4), OXCT1(8)	1450639	17	16	17	7	2	8	0	3	3	1	0.859	0.997	1.000
41	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CCL2(1), CSF1(2), IL1B(3), MST1R(14), TNF(3)	2815221	23	19	23	2	5	3	0	7	8	0	0.0528	0.997	1.000
42	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(3), HLCS(5), SPCS1(2), SPCS3(2)	1319135	12	11	12	5	3	1	0	7	1	0	0.793	0.998	1.000
43	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(6), CCNE1(5), CDC34(2), CDK2(3), CUL1(22), E2F1(3), RB1(13), SKP2(5), TFDP1(5)	3668575	64	46	62	15	12	25	2	10	15	0	0.0421	0.999	1.000
44	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	9	CASP3(2), CASP7(3), DFFA(4), DFFB(3), GZMB(3), HMGB2(4), TOP2A(5), TOP2B(9)	3795203	33	25	32	5	5	9	1	8	9	1	0.190	0.999	1.000
45	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYA(1), NFYC(2), RB1(13), SP1(6), SP3(3)	2854552	25	21	24	8	3	12	0	3	7	0	0.490	1.000	1.000
46	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(4), MTMR1(8), MTMR2(5), MTMR6(7), PHPT1(3), THTPA(2), TPK1(6)	2754764	35	27	35	9	9	11	1	5	9	0	0.210	1.000	1.000
47	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	ANP32A(2), APEX1(3), CREBBP(40), DFFA(4), DFFB(3), GZMA(3), GZMB(3), HMGB2(4), PRF1(8), SET(5)	4536200	75	49	74	18	22	20	2	15	16	0	0.0724	1.000	1.000
48	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(5), AASDHPPT(1), AASS(7), KARS(5)	2025504	18	14	18	5	4	6	1	5	2	0	0.423	1.000	1.000
49	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(4), MAPK14(1), MAPK8(5), NFKB1(7), RELA(5), TNFRSF13B(5), TNFRSF13C(4), TNFRSF17(1), TNFSF13(3), TNFSF13B(4), TRAF2(4), TRAF3(4), TRAF5(1), TRAF6(6)	6232278	54	42	54	9	9	15	2	10	16	2	0.0527	1.000	1.000
50	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(4), ARG1(2), GLS(10), GLUD1(2), OAT(2)	2367269	20	16	19	5	5	4	0	6	5	0	0.306	1.000	1.000
51	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), MIOX(5), UGDH(5)	3647197	55	39	47	14	10	15	0	13	17	0	0.329	1.000	1.000
52	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(1), FOSL1(1), FOSL2(8), IFNAR1(8), IFNAR2(6), IFNB1(3), MAPK8(5), NFKB1(7), RELA(5), TNFRSF11A(5), TNFSF11(4), TRAF6(6)	4754183	59	44	59	13	14	19	1	10	13	2	0.0700	1.000	1.000
53	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	11	AKT1(3), GRB2(4), KLK2(1), NTRK1(10), PIK3R1(11), PLCG1(19), PRKCA(5), SHC1(7), SOS1(7)	5743632	67	46	65	13	20	17	3	8	18	1	0.0384	1.000	1.000
54	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(5), HADH(3), HADHA(4), HADHB(5), HSD17B4(7), MECR(4), PPT1(6), PPT2(4)	3636190	38	24	37	7	7	14	3	2	12	0	0.0195	1.000	1.000
55	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(3), ACAA2(5), ACAT1(5), ACAT2(4), EHHADH(7), HADHA(4), HADHB(5), SDS(4)	3589460	37	24	36	9	6	15	2	2	11	1	0.170	1.000	1.000
56	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	CREB1(3), FOS(1), JUN(4), KEAP1(10), MAFF(1), MAPK1(3), MAPK14(1), MAPK8(5), NFE2L2(1), PRKCA(5)	3802548	34	27	34	9	9	12	2	3	7	1	0.157	1.000	1.000
57	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(1), CD3E(2), CD3G(1), IFNG(2), IL2RA(3), IL4(1), TGFB1(3), TGFB2(6), TGFB3(8), TGFBR1(4), TGFBR2(14), TGFBR3(7), TOB1(1), TOB2(5)	4545011	58	45	58	14	11	18	6	11	12	0	0.150	1.000	1.000
58	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(31), GNA12(1), PRKACB(4), PRKACG(8), PRKAG1(4), PRKAR2A(2), PRKAR2B(8)	4333423	58	42	53	12	11	15	2	7	21	2	0.143	1.000	1.000
59	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(2), ACADM(4), ACADS(4), ACAT1(5), HADHA(4)	2318194	19	15	18	5	6	5	0	2	5	1	0.319	1.000	1.000
60	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ3(5), COQ5(1), COQ6(3), COQ7(4), NDUFA12(2), NDUFB11(2)	1713010	17	15	17	7	5	4	0	3	5	0	0.782	1.000	1.000
61	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(8), ACO2(9), FH(3), IDH1(2), IDH2(4), MDH1(3), SDHB(4), SUCLA2(4)	3823863	37	26	34	7	15	9	0	5	8	0	0.0769	1.000	1.000
62	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(2), ASL(6), CPS1(22), GLS(10), GLUD1(2), GOT1(3)	3350542	45	37	44	11	14	10	2	14	5	0	0.151	1.000	1.000
63	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(1), EHHADH(7), HADHA(4), SDS(4)	2082074	16	13	15	5	4	4	1	2	5	0	0.418	1.000	1.000
64	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(4), CHRNA1(5), SNAP25(2), STX1A(3), VAMP2(2)	1400328	16	15	15	5	3	2	1	5	5	0	0.708	1.000	1.000
65	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	5	BCL2(3), CASP3(2), CFL1(1), CFLAR(1), PDE6D(1)	1160480	8	7	8	4	2	4	0	1	1	0	0.791	1.000	1.000
66	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(6), F13B(16), HSD17B1(4), HSD17B2(2), HSD17B3(1), HSD17B4(7), HSD17B7(3), HSD3B1(4), HSD3B2(1)	3473806	44	36	44	12	7	14	3	11	9	0	0.184	1.000	1.000
67	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	16	CD28(1), CD3E(2), CD3G(1), CD80(4), CD86(6), CTLA4(3), GRB2(4), HLA-DRA(8), ICOS(2), ITK(6), LCK(4), PIK3R1(11), PTPN11(6)	4558122	58	46	56	13	16	15	2	10	14	1	0.176	1.000	1.000
68	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	16	AKT1(3), CREB1(3), GRB2(4), MAPK1(3), MAPK3(1), MAPK7(6), MEF2A(2), MEF2B(5), MEF2C(4), MEF2D(7), NTRK1(10), PIK3R1(11), PLCG1(19), RPS6KA1(9), SHC1(7)	7178204	94	57	91	19	27	26	6	10	24	1	0.00860	1.000	1.000
69	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(40), EP300(22), ESR1(9), MAPK1(3), MAPK3(1), PELP1(6), SRC(3)	6296008	84	55	82	18	30	22	2	13	16	1	0.0136	1.000	1.000
70	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CCL3(1), CSF3(2), EPO(1), FLT3(10), IGF1(4), IL11(3), IL1A(2), IL3(1), KITLG(3), TGFB1(3), TGFB2(6), TGFB3(8)	3560367	44	33	43	10	12	11	1	12	8	0	0.136	1.000	1.000
71	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(7), ALDH1A2(5), RDH5(2)	1676358	14	14	14	9	4	2	0	4	4	0	0.967	1.000	1.000
72	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(12), PDXK(3), PDXP(2), PSAT1(5)	2075630	22	17	22	9	2	7	0	8	4	1	0.749	1.000	1.000
73	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	12	APC(43), CREBBP(40), EP300(22), MAP2K1(5), MAP3K7(10), MAPK3(1), SKIL(2), TGFB1(3), TGFB2(6), TGFB3(8), TGFBR1(4), TGFBR2(14)	10290478	158	89	152	33	38	43	5	25	38	9	0.0113	1.000	1.000
74	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM1(2), CALM2(2), CAMK1(3), CAMK1G(6), CAMK2A(3), CAMK2B(4), CAMK2D(3), CAMK2G(8), CAMK4(8), ESRRA(2), HDAC5(10), MEF2A(2), MEF2B(5), MEF2C(4), MEF2D(7), PPARA(4), PPP3CA(10), PPP3CB(6), PPP3CC(5), SLC2A4(4), SYT1(4), YWHAH(3)	8662424	105	71	102	24	28	22	6	21	28	0	0.0200	1.000	1.000
75	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(7), ALDH1A2(5), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4)	3425297	57	36	49	18	12	13	0	11	21	0	0.624	1.000	1.000
76	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(7), ALDH1A2(5), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4)	3425297	57	36	49	18	12	13	0	11	21	0	0.624	1.000	1.000
77	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM1(2), CALM2(2), CCL2(1), CCR5(4), CXCR4(1), FOS(1), GNAQ(4), JUN(4), MAPK14(1), MAPK8(5), PLCG1(19), PRKCA(5), PTK2B(16), SYT1(4)	5936561	69	50	67	15	23	18	3	10	14	1	0.0303	1.000	1.000
78	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(3), GOT2(2), TAT(5)	1128324	10	10	10	7	4	3	0	2	1	0	0.925	1.000	1.000
79	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(26), ABCB11(9), ABCB4(23), ABCC1(16), ABCC3(11), GSTP1(1)	6158288	86	59	83	21	21	19	3	17	24	2	0.0784	1.000	1.000
80	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	11	APAF1(8), ARHGAP5(18), ARHGDIB(1), CASP1(4), CASP10(6), CASP3(2), CASP9(3), GZMB(3), JUN(4), PRF1(8)	5030725	57	41	49	12	11	10	3	11	21	1	0.313	1.000	1.000
81	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(12), APOBEC1(3), APOBEC2(3), APOBEC3A(1), APOBEC3B(3), APOBEC3F(1), APOBEC3G(3), APOBEC4(1)	3143328	27	20	27	6	9	6	3	5	4	0	0.241	1.000	1.000
82	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(5), COASY(3), DPYD(16), DPYS(7), ENPP1(7), ENPP3(8), PANK1(9), PANK2(4), PANK3(2), PANK4(3), PPCS(2), UPB1(4)	5982354	70	45	67	14	12	18	3	19	18	0	0.0217	1.000	1.000
83	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	13	ARF1(5), CCND1(1), CDK2(3), CDKN1A(3), CFL1(1), E2F1(3), E2F2(4), MDM2(5), NXT1(2), PRB1(4)	3015642	31	24	30	8	8	12	1	3	6	1	0.254	1.000	1.000
84	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(4), CAMP(2), DAG1(13), GNAQ(4), ITPKA(2), ITPKB(11)	2599369	36	28	35	10	13	9	0	8	6	0	0.226	1.000	1.000
85	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREB1(3), CREM(4), FOS(1), JUN(4), MAPK3(1), OPRK1(14), POLR2A(19), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8)	5533905	77	54	72	19	19	24	2	14	18	0	0.0612	1.000	1.000
86	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(4), ADH1B(4), ADH4(2), ADH5(3), ADH6(7), ADH7(1), ADHFE1(9), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4)	5671490	75	47	66	19	12	19	0	20	23	1	0.267	1.000	1.000
87	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(9), ACO1(8), ACO2(9), ACSS1(12), ACSS2(10), FH(3), IDH1(2), IDH2(4), MDH1(3), SUCLA2(4)	5715576	64	41	60	14	22	13	3	10	16	0	0.0685	1.000	1.000
88	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(14), AP2A1(9), AP2M1(7), BIN1(4), CALM1(2), CALM2(2), DNM1(5), EPN1(5), EPS15(2), NME2(3), PICALM(2), PPP3CA(10), PPP3CB(6), PPP3CC(5), SYNJ1(10), SYNJ2(18), SYT1(4)	9305231	108	66	100	22	30	21	3	22	32	0	0.0120	1.000	1.000
89	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	20	CSNK2A1(5), ELK1(3), FOS(1), GRB2(4), INSR(14), IRS1(24), JUN(4), MAP2K1(5), MAPK3(1), MAPK8(5), PIK3R1(11), PTPN11(6), RAF1(10), RASA1(17), SHC1(7), SLC2A4(4), SOS1(7), SRF(2)	10000033	130	70	122	29	34	32	3	18	40	3	0.0196	1.000	1.000
90	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA1(1), NDUFA10(4), NDUFA8(5), NDUFB2(1), NDUFB4(1), NDUFB5(1), NDUFB6(1), NDUFB7(1), NDUFS1(7), NDUFS2(5), NDUFV1(5)	2969101	32	25	31	7	6	8	1	8	9	0	0.418	1.000	1.000
91	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(22), CPT1A(10), LEP(2), LEPR(13), PRKAA1(6), PRKAA2(7), PRKAB1(6), PRKAB2(4), PRKAG1(4), PRKAG2(5)	6213129	79	49	77	16	21	14	3	21	18	2	0.0892	1.000	1.000
92	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	8	CCNB1(3), CCNH(2), CDC25A(6), CDC25B(4), MNAT1(3), SHH(4), XPO1(7)	3272546	29	18	29	8	7	10	1	7	4	0	0.311	1.000	1.000
93	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(10), PARK2(10), SNCA(1), SNCAIP(13), UBE2F(3), UBE2G2(2), UBE2L3(1), UBE2L6(1)	2761315	41	32	40	14	11	12	1	8	8	1	0.422	1.000	1.000
94	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(8), BAD(3), BAK1(4), BAX(6), BCL10(2), BCL2(3), BCL2L11(1), BID(2), CASP9(3), CES1(7)	4675335	39	27	34	8	14	9	1	6	9	0	0.176	1.000	1.000
95	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(4), PAPSS1(6), PAPSS2(5), SULT1A2(5), SULT1E1(2), SULT2A1(3), SUOX(3)	2625444	28	23	28	7	11	10	0	3	4	0	0.289	1.000	1.000
96	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	19	AKT1(3), APAF1(8), ATM(38), BAD(3), BAX(6), BCL2(3), BID(2), CASP3(2), CASP6(1), CASP7(3), CASP9(3), EIF2S1(2), PRKCA(5), PTK2(11), PXN(4), STAT1(10), TLN1(23)	11394930	127	72	116	27	35	32	6	16	35	3	0.0254	1.000	1.000
97	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5(2), CDK5R1(4), DAB1(9), FYN(10), LRP8(6), RELN(47), VLDLR(6)	6019362	84	55	83	23	23	30	3	16	12	0	0.0561	1.000	1.000
98	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	17	APAF1(8), BAK1(4), BAX(6), BCL2(3), BID(2), BIRC2(3), BIRC3(6), CASP3(2), CASP6(1), CASP7(3), CASP9(3), DFFA(4), DFFB(3), DIABLO(1)	5257789	49	35	43	10	13	14	0	9	13	0	0.184	1.000	1.000
99	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	14	AKT1(3), BCAR1(8), GRB2(4), ILK(8), ITGB1(10), MAPK1(3), MAPK3(1), PDPK1(2), PIK3R1(11), PTK2(11), SHC1(7), SOS1(7)	6969290	75	47	70	15	20	17	4	11	21	2	0.0526	1.000	1.000
100	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(5), PLCG1(19), PRKCA(5), PTK2B(16)	2899870	45	37	44	12	20	8	2	4	11	0	0.199	1.000	1.000
101	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	CREB1(3), GRB2(4), PTK2B(16), SHC1(7), SOS1(7), SRC(3)	3796620	40	29	40	10	12	10	0	8	10	0	0.296	1.000	1.000
102	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(11), BMPR1A(5), BMPR1B(7), BMPR2(16)	2689015	39	33	36	10	9	8	2	3	15	2	0.469	1.000	1.000
103	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	10	ATM(38), CDC25A(6), CDC25B(4), CDK2(3), CHEK1(4), MYT1(19), RB1(13), WEE1(4), YWHAH(3)	6778483	94	62	87	21	18	26	3	18	26	3	0.156	1.000	1.000
104	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(6), CYSLTR2(1), GPR161(12), GPR171(2), GPR18(3), GPR39(9), GPR45(12), GPR65(2), GPR68(3), GPR75(5)	4226763	55	40	50	16	21	8	4	8	14	0	0.316	1.000	1.000
105	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(4), CR1(27), CR2(22), FCGR2B(1), HLA-DRA(8), ICAM1(2), ITGAL(16), ITGB2(6), PTPRC(19)	6527237	105	65	92	29	26	31	0	22	26	0	0.183	1.000	1.000
106	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	17	CSNK2A1(5), ELK1(3), FOS(1), GRB2(4), JUN(4), KLK2(1), MAP2K1(5), MAPK3(1), MAPK8(5), NGFR(4), PIK3R1(11), PLCG1(19), RAF1(10), SHC1(7), SOS1(7)	7265976	87	54	82	21	26	21	3	16	19	2	0.0616	1.000	1.000
107	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(5), BCAT2(6), COASY(3), DPYD(16), DPYS(7), ENPP1(7), ENPP3(8), ILVBL(5), PANK1(9), PANK2(4), PANK3(2), PANK4(3), PPCDC(1), PPCS(2), UPB1(4), VNN1(4)	7431209	86	51	83	17	21	20	3	23	19	0	0.00994	1.000	1.000
108	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	8	CHUK(4), DNAJC3(3), EIF2S1(2), EIF2S2(2), NFKB1(7), NFKBIA(1), RELA(5)	3842638	24	18	24	5	4	6	0	8	6	0	0.330	1.000	1.000
109	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	29	AGPAT1(3), AGPAT2(2), AGPAT3(4), AGPAT4(5), AGPAT6(5), AGPS(2), CHPT1(3), ENPP2(9), ENPP6(6), PAFAH1B1(12), PAFAH1B2(2), PAFAH1B3(2), PAFAH2(3), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G2A(2), PLA2G2D(1), PLA2G2E(4), PLA2G3(9), PLA2G4A(6), PLA2G5(1), PLA2G6(6), PLD1(19), PLD2(16), PPAP2A(3), PPAP2B(1), PPAP2C(4)	9818237	135	65	130	25	40	38	4	25	28	0	0.00123	1.000	1.000
110	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	15	APAF1(8), ATM(38), BAX(6), BCL2(3), CCND1(1), CCNE1(5), CDK2(3), CDKN1A(3), E2F1(3), MDM2(5), PCNA(2), RB1(13), TIMP3(6)	7424035	96	59	83	22	18	25	2	15	32	4	0.263	1.000	1.000
111	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	14	APAF1(8), BIRC2(3), BIRC3(6), CASP10(6), CASP3(2), CASP7(3), CASP9(3), DFFA(4), DFFB(3), GZMB(3), PRF1(8), SCAP(13), SREBF1(12), SREBF2(11)	7274561	85	56	80	18	26	19	2	17	20	1	0.0790	1.000	1.000
112	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	BET1(1), BNIP1(5), GOSR1(2), GOSR2(2), SNAP25(2), SNAP29(1), STX10(3), STX11(7), STX12(2), STX16(8), STX17(2), STX18(2), STX19(3), STX2(6), STX3(2), STX4(4), STX5(1), STX6(7), STX7(2), STX8(5), TSNARE1(7), USE1(3), VAMP2(2), VAMP4(1), VAMP5(1), VAMP7(5), VTI1A(3), VTI1B(4), YKT6(1)	7168770	94	53	90	20	32	23	2	14	22	1	0.0358	1.000	1.000
113	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	25	AKT1(3), APC(43), AXIN1(9), CCND1(1), CD14(2), CTNNB1(22), DVL1(7), FZD1(10), GJA1(11), GNAI1(1), GSK3B(5), IRAK1(6), LBP(1), LEF1(8), LY96(4), MYD88(2), NFKB1(7), PDPK1(2), PIK3R1(11), PPP2CA(4), RELA(5), TIRAP(1), TLR4(21), TOLLIP(5), WNT1(8)	12240489	199	109	185	46	40	46	6	42	55	10	0.0220	1.000	1.000
114	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(8), IFNB1(3), JAK1(12), PTPRU(25), REG1A(4), STAT1(10), STAT2(10), TYK2(9)	5357141	81	52	75	21	24	18	0	9	30	0	0.239	1.000	1.000
115	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(10), F13A1(14), F2(9), F2R(3), FGA(9), FGB(4), FGG(3), PLAT(7), PLG(14), SERPINB2(7), SERPINE1(3)	5760920	83	55	79	25	25	13	7	23	15	0	0.287	1.000	1.000
116	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(4), CDO1(1), CSAD(8), GAD1(7), GAD2(9), GGT1(6)	2466206	35	29	34	12	14	4	1	6	10	0	0.382	1.000	1.000
117	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(2), LDLR(10), MBTPS1(12), MBTPS2(5), SCAP(13), SREBF1(12), SREBF2(11)	5077584	65	44	62	18	21	14	1	10	18	1	0.233	1.000	1.000
118	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(3), IFNG(2), IFNGR1(6), JAK1(12), JAK2(13), PLA2G2A(2), PTPRU(25), REG1A(4), STAT1(10)	4913590	77	52	76	21	20	21	2	11	22	1	0.221	1.000	1.000
119	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	BPNT1(4), CHST11(4), CHST12(5), CHST13(4), PAPSS1(6), PAPSS2(5), SULT1A1(6), SULT1A2(5), SULT1E1(2), SULT2A1(3), SUOX(3)	3956462	47	34	46	13	22	12	1	8	4	0	0.152	1.000	1.000
120	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(6), CDKN1A(3), EPO(1), EPOR(3), GRIN1(8), HIF1A(7), JAK2(13), NFKB1(7), NFKBIA(1), RELA(5), SOD2(1)	5428608	55	37	54	14	8	16	2	10	18	1	0.285	1.000	1.000
121	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	7	ATM(38), CDC25A(6), CDC25B(4), CHEK1(4), MYT1(19), WEE1(4), YWHAH(3)	5492608	78	55	72	21	18	19	2	16	20	3	0.401	1.000	1.000
122	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	16	ADRB2(8), AKT1(3), ANXA1(2), CALM1(2), CALM2(2), GNAS(29), GNB1(1), GNGT1(3), NFKB1(7), NOS3(10), NPPA(2), NR3C1(6), PIK3R1(11), RELA(5), SYT1(4)	6765194	95	64	88	21	36	21	0	18	19	1	0.0668	1.000	1.000
123	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	7	B3GAT3(4), B4GALT7(5), HS3ST1(3), HS3ST2(10), HS3ST3A1(2), HS3ST3B1(4), XYLT1(12)	2142388	40	33	38	13	18	11	1	5	5	0	0.270	1.000	1.000
124	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	7	B3GAT3(4), B4GALT7(5), HS3ST1(3), HS3ST2(10), HS3ST3A1(2), HS3ST3B1(4), XYLT1(12)	2142388	40	33	38	13	18	11	1	5	5	0	0.270	1.000	1.000
125	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	28	CSF1(2), CSF3(2), HLA-DRA(8), IFNA1(1), IFNB1(3), IFNG(2), IL10(2), IL11(3), IL12A(2), IL12B(2), IL13(2), IL1A(2), IL3(1), IL4(1), IL7(1), LTA(4), PDGFA(2), TGFB1(3), TGFB2(6), TGFB3(8), TNF(3)	5328049	60	44	60	18	18	16	2	13	11	0	0.293	1.000	1.000
126	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(7), ST3GAL1(4), ST3GAL2(6), ST3GAL4(6), ST3GAL5(3), ST6GALNAC2(1), ST6GALNAC4(2), ST8SIA1(7)	2426528	36	33	35	13	18	4	2	8	4	0	0.535	1.000	1.000
127	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(7), ALDH1A2(5), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), EHHADH(7), HADHA(4), SDS(4)	5216751	72	40	63	23	16	17	0	13	26	0	0.530	1.000	1.000
128	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(14), GABRA2(9), GABRA3(10), GABRA4(9), GABRA5(7), GABRA6(10), PRKCE(14)	3377064	73	49	72	27	18	14	8	26	7	0	0.543	1.000	1.000
129	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(15), EIF2AK4(10), EIF2B5(9), EIF2S1(2), EIF2S2(2), EIF5(6), GSK3B(5), PPP1CA(2)	4952517	51	40	51	13	10	15	1	14	11	0	0.262	1.000	1.000
130	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	AKR1A1(1), EHHADH(7), HADH(3), HADHA(4), HSD17B4(7), NTAN1(5), SIRT1(6), SIRT2(3), SIRT5(4), SIRT7(3), VNN2(3)	5090453	46	28	43	12	12	10	4	4	16	0	0.210	1.000	1.000
131	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAD(4), ALAS1(3), ALAS2(12), CPO(5), FECH(6), GATA1(3), HBB(2), HMBS(3), UROD(1), UROS(4)	3377482	43	34	43	11	9	11	2	11	10	0	0.303	1.000	1.000
132	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(3), FOS(1), JUN(4), MAP2K1(5), MAPK1(3), MAPK3(1), MYC(5), NFKB1(7), NFKBIA(1), PLCB1(19), PRKCA(5), RAF1(10), RELA(5), TNF(3)	6678768	72	50	69	19	20	15	1	18	18	0	0.165	1.000	1.000
133	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(6), ASPH(6), COPS5(3), CREB1(3), EDN1(3), EP300(22), EPO(1), HIF1A(7), JUN(4), LDHA(3), NOS3(10), P4HB(4), VHL(2)	7285971	74	48	70	17	17	17	5	13	21	1	0.107	1.000	1.000
134	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(30), C5(11), C6(12), C7(3), C8A(5), C9(7)	5387439	68	43	64	19	21	17	3	14	13	0	0.201	1.000	1.000
135	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	22	BCAR1(8), CXCR4(1), GNAI1(1), GNAQ(4), GNB1(1), GNGT1(3), MAP2K1(5), MAPK1(3), MAPK3(1), NFKB1(7), PIK3C2G(10), PIK3R1(11), PLCG1(19), PRKCA(5), PTK2(11), PTK2B(16), PXN(4), RAF1(10), RELA(5)	10890758	125	71	119	29	36	24	5	21	38	1	0.0354	1.000	1.000
136	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(5), CHPT1(3), HEMK1(1), LCMT1(1), LCMT2(11), METTL6(3), PCYT1A(9), PCYT1B(6), PRMT2(8), PRMT3(5), PRMT5(3), PRMT6(4), PRMT7(6), PRMT8(9), WBSCR22(6)	6030990	80	47	75	20	19	23	3	13	21	1	0.131	1.000	1.000
137	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(16), KHK(2), LCT(23), MPI(3), PGM1(2), PYGL(8), PYGM(14), TPI1(1), TREH(1)	5752710	70	52	70	20	32	17	2	8	11	0	0.123	1.000	1.000
138	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNA1(1), IFNAR1(8), IFNAR2(6), IFNB1(3), JAK1(12), STAT1(10), STAT2(10), TYK2(9)	4649991	59	40	54	17	13	15	0	8	23	0	0.476	1.000	1.000
139	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(9), GBA(9), LPO(9), MPO(7), PRDX6(2), TPO(24)	3585382	60	50	59	18	21	12	3	15	8	1	0.329	1.000	1.000
140	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	20	AKT1(3), EIF4A1(3), EIF4A2(6), EIF4E(2), EIF4EBP1(2), EIF4G1(23), EIF4G2(7), EIF4G3(17), GHR(6), IRS1(24), MAPK1(3), MAPK14(1), MAPK3(1), MKNK1(3), PABPC1(2), PDPK1(2), PIK3R1(11), PRKCA(5), RPS6KB1(5)	10790254	126	72	119	27	30	32	5	21	36	2	0.0520	1.000	1.000
141	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS1(2), DHRS3(2), DHRS7(6), DHRSX(5), ESCO1(7), ESCO2(8), NAT6(3), PNPLA3(2), SH3GLB1(3)	7112853	38	33	37	9	10	7	1	5	14	1	0.415	1.000	1.000
142	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(5), ACP2(4), ACP5(2), ACP6(3), ACPP(3), ACPT(4), ENPP1(7), ENPP3(8), FLAD1(4), LHPP(4), MTMR1(8), MTMR2(5), MTMR6(7), PHPT1(3), RFK(1), TYR(9)	6452624	77	52	73	20	16	22	4	14	21	0	0.137	1.000	1.000
143	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(6), ALOX15(7), ALOX15B(3), ALOX5(10), ALOX5AP(3), DPEP1(2), GGT1(6), LTA4H(5), PLA2G2A(2), PLA2G6(6), PTGDS(1), PTGIS(6), PTGS1(12), PTGS2(7), TBXAS1(6)	6445417	82	53	81	20	33	15	4	13	17	0	0.0308	1.000	1.000
144	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	13	DHCR7(6), FDFT1(2), FDPS(9), HMGCR(7), IDI1(2), LSS(9), MVD(2), NQO1(3), NQO2(3), PMVK(1), SQLE(5), VKORC1(1)	4376286	50	31	47	15	14	12	1	12	11	0	0.356	1.000	1.000
145	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(4), ACAD9(6), ADH1A(4), ADH1B(4), ADH4(2), ADH5(3), ADH6(7), ADH7(1), ADHFE1(9), DHRS1(2), DHRS3(2), DHRS7(6), DHRSX(5), ESCO1(7), ESCO2(8), NAT6(3), PNPLA3(2), SH3GLB1(3)	10717969	78	49	76	16	17	21	2	16	20	2	0.0614	1.000	1.000
146	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(2), ACADM(4), ACADS(4), ACADVL(1), ACSL1(3), ACSL3(8), ACSL4(4), CPT1A(10), CPT2(5), EHHADH(7), HADHA(4), PECR(1), SCP2(5), SLC25A20(2)	7219115	60	40	58	16	17	11	5	11	16	0	0.131	1.000	1.000
147	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(4), ALAS1(3), ALAS2(12), CPOX(2), FECH(6), HMBS(3), PPOX(5), UROD(1), UROS(4)	3258406	40	34	40	10	7	12	2	10	9	0	0.304	1.000	1.000
148	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(5), AOC2(6), AOC3(15), CES1(7), DDHD1(9), ESCO1(7), ESCO2(8), LIPA(3), NAT6(3), PLA1A(2), PNPLA3(2), PPME1(1), PRDX6(2), SH3GLB1(3)	10873015	73	52	64	15	16	12	2	17	25	1	0.288	1.000	1.000
149	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(3), CAMK1G(6), HDAC9(8), MEF2A(2), MEF2B(5), MEF2C(4), MEF2D(7), MYOD1(6), YWHAH(3)	3317406	44	37	43	16	14	7	4	6	13	0	0.512	1.000	1.000
150	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	21	APC(43), AXIN1(9), BTRC(9), CCND1(1), CREBBP(40), CSNK1A1(3), CSNK1D(2), CSNK2A1(5), CTBP1(3), CTNNB1(22), DVL1(7), FZD1(10), GSK3B(5), HDAC1(5), MAP3K7(10), MYC(5), PPARD(8), PPP2CA(4), TLE1(9), WIF1(2), WNT1(8)	12204299	210	106	194	52	62	43	6	31	59	9	0.0405	1.000	1.000
151	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	ASAH1(4), BFAR(5), BRAF(16), CAMP(2), CREB1(3), CREB5(5), MAPK1(3), RAF1(10), SNX13(7), SRC(3), TERF2IP(5)	4797663	63	46	57	18	17	12	1	14	19	0	0.433	1.000	1.000
152	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(6), ENO1(3), GPI(5), HK1(16), PFKL(5), PGK1(4), PKLR(7), TPI1(1)	3978561	47	37	47	15	15	14	2	11	5	0	0.263	1.000	1.000
153	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	14	ACOX1(5), ACOX3(11), FADS2(5), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G2A(2), PLA2G2D(1), PLA2G2E(4), PLA2G3(9), PLA2G4A(6), PLA2G5(1), PLA2G6(6)	4222162	55	42	53	18	23	10	3	14	5	0	0.407	1.000	1.000
154	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(3), B4GALT1(2), B4GALT2(7), B4GALT3(2), B4GALT5(6), FUT8(7), ST3GAL1(4), ST3GAL2(6), ST3GAL3(2), ST3GAL4(6)	3390971	45	37	44	13	20	11	0	6	8	0	0.353	1.000	1.000
155	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(4), NFKB1(7), NFKBIA(1), PLCB1(19), PRKCA(5), RELA(5)	3539135	41	33	40	13	11	8	0	9	13	0	0.516	1.000	1.000
156	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(4), GALNT10(7), GALNT2(5), GALNT3(4), GALNT4(5), GALNT6(6), GALNT7(2), GALNT8(6), GALNT9(3), ST3GAL1(4), ST3GAL2(6), ST3GAL4(6), WBSCR17(25)	6199575	83	57	80	24	33	14	4	14	17	1	0.346	1.000	1.000
157	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	20	BAD(3), BAX(6), BCL2(3), FADD(1), MAP2K1(5), MAP2K4(8), MAP3K1(11), MAPK1(3), MAPK3(1), MAPK8(5), NFKB1(7), NSMAF(9), RAF1(10), RELA(5), RIPK1(2), SMPD1(6), TNFRSF1A(6), TRADD(2), TRAF2(4)	8297031	97	57	89	25	32	20	2	11	29	3	0.125	1.000	1.000
158	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(3), PSMA2(1), PSMA3(3), PSMA4(4), PSMA6(5), PSMA7(4), PSMB1(2), PSMB10(1), PSMB2(2), PSMB3(2), PSMB4(3), PSMB5(1), PSMB6(3), PSMB8(5), PSMB9(1)	3747289	40	26	39	13	13	12	2	7	6	0	0.351	1.000	1.000
159	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(5), ELK1(3), EPO(1), EPOR(3), FOS(1), GRB2(4), JAK2(13), JUN(4), MAP2K1(5), MAPK3(1), MAPK8(5), PLCG1(19), PTPN6(4), RAF1(10), SHC1(7), SOS1(7), STAT5A(3), STAT5B(14)	9231320	109	60	103	28	28	31	3	21	24	2	0.0966	1.000	1.000
160	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	21	CSNK2A1(5), FOS(1), GRB2(4), JAK2(13), JUN(4), MAP2K1(5), MAPK3(1), MPL(5), PIK3R1(11), PLCG1(19), PRKCA(5), RAF1(10), RASA1(17), SHC1(7), SOS1(7), STAT1(10), STAT3(7), STAT5A(3), STAT5B(14), THPO(6)	11933697	154	80	145	31	36	38	5	29	44	2	0.00968	1.000	1.000
161	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(3), ENO2(3), ENO3(4), FARS2(7), GOT1(3), GOT2(2), PAH(6), TAT(5), YARS(6)	3566422	39	28	39	12	12	11	0	9	7	0	0.378	1.000	1.000
162	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(3), GNAS(29), GNB1(1), GNGT1(3), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), PRKCA(5)	4145607	72	50	67	21	35	11	1	9	16	0	0.397	1.000	1.000
163	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(3), PSMA2(1), PSMA3(3), PSMA4(4), PSMA6(5), PSMA7(4), PSMB1(2), PSMB2(2), PSMB3(2), PSMB4(3), PSMB5(1), PSMB6(3), PSMC2(6), PSMC3(8), PSMD1(6), PSMD11(3), PSMD12(4), PSMD13(2), PSMD2(14), PSMD6(2)	6859759	78	46	77	18	22	23	4	14	15	0	0.0755	1.000	1.000
164	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(22), ACACB(35), FASN(19), MCAT(3), OXSM(4)	6763071	83	49	80	24	23	19	4	20	16	1	0.192	1.000	1.000
165	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	30	ANPEP(9), G6PD(5), GCLC(3), GCLM(3), GGT1(6), GPX2(3), GPX3(1), GPX5(2), GSS(3), GSTA1(3), GSTA2(2), GSTA3(1), GSTA4(2), GSTM2(1), GSTM3(2), GSTM4(3), GSTM5(2), GSTO2(3), GSTP1(1), GSTZ1(3), IDH1(2), IDH2(4), MGST1(3), MGST2(3), MGST3(3), PGD(6)	7719621	79	51	74	20	20	17	1	19	22	0	0.253	1.000	1.000
166	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	17	AKT1(3), EIF2B5(9), EIF2S1(2), EIF2S2(2), EIF4E(2), EIF4EBP1(2), GSK3B(5), IGF1(4), IGF1R(16), INPPL1(24), PDPK1(2), PIK3R1(11), PPP2CA(4), RPS6(1), RPS6KB1(5)	7140971	92	53	85	24	25	23	2	15	25	2	0.255	1.000	1.000
167	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(3), JAK1(12), JAK2(13), JAK3(13), PIAS1(12), PIAS3(7), PTPRU(25), REG1A(4), SOAT1(7)	5871529	96	54	88	27	24	22	2	14	33	1	0.471	1.000	1.000
168	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	15	AKT1(3), CREB1(3), MAP2K1(5), MAP2K2(3), MAP2K3(4), MAP2K6(1), MAP3K1(11), MAPK1(3), MAPK14(1), MAPK3(1), NFKB1(7), PIK3R1(11), RB1(13), RELA(5), SP1(6)	7383016	77	53	72	20	13	27	1	11	24	1	0.187	1.000	1.000
169	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	15	BCL2(3), CREBBP(40), EP300(22), FYN(10), IL2RG(6), IL7(1), IL7R(9), JAK1(12), JAK3(13), LCK(4), NMI(1), PIK3R1(11), PTK2B(16), STAT5A(3), STAT5B(14)	11051291	165	73	156	34	42	44	1	30	46	2	0.00888	1.000	1.000
170	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	15	B3GAT1(7), B3GAT2(6), B3GAT3(4), B4GALT7(5), CHPF(2), CHST11(4), CHST12(5), CHST13(4), CHST14(1), CHST3(3), CHST7(7), CHSY1(6), DSE(6), UST(9), XYLT1(12)	5331889	81	48	79	24	38	22	2	12	7	0	0.100	1.000	1.000
171	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	17	IL18(1), ITGB1(10), KLRC1(3), KLRC3(2), KLRD1(3), LAT(3), MAP2K1(5), MAPK3(1), PAK1(5), PIK3R1(11), PTK2B(16), PTPN6(4), SYK(7), VAV1(9)	6626596	80	58	75	23	17	24	0	18	20	1	0.315	1.000	1.000
172	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(5), GABRA1(14), GABRA2(9), GABRA3(10), GABRA4(9), GABRA5(7), GABRA6(10), GPHN(11), NSF(1), SRC(3), UBQLN1(5)	5132607	84	52	83	29	16	19	10	30	9	0	0.508	1.000	1.000
173	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM1(2), CALM2(2), CAMK1(3), CAMK1G(6), CAMK2A(3), CAMK2B(4), CAMK2D(3), CAMK2G(8), CAMK4(8), CAMKK1(5), CAMKK2(2), CREB1(3), SYT1(4)	4950394	53	39	52	18	13	17	4	7	12	0	0.320	1.000	1.000
174	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(5), ACP2(4), ACP5(2), ACPP(3), ACPT(4), ENPP1(7), ENPP3(8), FLAD1(4), RFK(1), TYR(9)	4164477	47	35	43	14	7	14	3	9	14	0	0.448	1.000	1.000
175	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(7), CYB5R3(4), GCK(4), GFPT1(4), GNE(7), GNPDA1(4), GNPDA2(6), HEXA(2), HEXB(3), HK1(16), HK2(10), HK3(6), PGM3(7), RENBP(2), UAP1(5)	7274408	87	58	87	24	28	25	4	15	15	0	0.103	1.000	1.000
176	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(3), CHUK(4), IFNG(2), IKBKB(8), IL4(1), JUN(4), MAP3K1(11), MAP3K5(5), MAP4K5(1), MAPK14(1), MAPK8(5), NFKB1(7), NFKBIA(1), RELA(5), TNFRSF9(11), TRAF2(4)	8291564	73	45	67	18	20	10	3	13	25	2	0.280	1.000	1.000
177	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(3), CAT(5), EPX(9), LPO(9), MPO(7), MTHFR(9), PRDX6(2), SHMT1(2), SHMT2(9), TPO(24)	4968930	79	60	77	23	28	10	4	18	18	1	0.315	1.000	1.000
178	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GSR(5), GSS(3), NFKB1(7), NOX1(6), RELA(5), TNF(3), XDH(14)	4262484	43	28	43	14	7	14	2	10	10	0	0.486	1.000	1.000
179	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	21	ATP6AP1(6), ATP6V0A1(5), ATP6V0A4(10), ATP6V0B(4), ATP6V0D1(8), ATP6V1A(6), ATP6V1B2(5), ATP6V1C1(2), ATP6V1C2(12), ATP6V1D(3), ATP6V1E1(2), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(7), FDXR(7), SHMT1(2)	6417659	84	56	81	24	24	21	4	15	20	0	0.229	1.000	1.000
180	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	20	ATP6AP1(6), ATP6V0A1(5), ATP6V0A4(10), ATP6V0B(4), ATP6V0D1(8), ATP6V1A(6), ATP6V1B2(5), ATP6V1C1(2), ATP6V1C2(12), ATP6V1D(3), ATP6V1E1(2), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(7), SHMT1(2)	6005714	77	53	74	23	21	19	3	15	19	0	0.346	1.000	1.000
181	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	20	ATP6AP1(6), ATP6V0A1(5), ATP6V0A4(10), ATP6V0B(4), ATP6V0D1(8), ATP6V1A(6), ATP6V1B2(5), ATP6V1C1(2), ATP6V1C2(12), ATP6V1D(3), ATP6V1E1(2), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(7), SHMT1(2)	6005714	77	53	74	23	21	19	3	15	19	0	0.346	1.000	1.000
182	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	20	ATP6AP1(6), ATP6V0A1(5), ATP6V0A4(10), ATP6V0B(4), ATP6V0D1(8), ATP6V1A(6), ATP6V1B2(5), ATP6V1C1(2), ATP6V1C2(12), ATP6V1D(3), ATP6V1E1(2), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(7), SHMT1(2)	6005714	77	53	74	23	21	19	3	15	19	0	0.346	1.000	1.000
183	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	19	AKT1(3), BAD(3), CASP9(3), CDC42(1), CHUK(4), ELK1(3), MAP2K1(5), MAPK3(1), NFKB1(7), PIK3R1(11), RAF1(10), RALBP1(8), RALGDS(11), RELA(5)	7080019	75	48	71	21	22	20	2	11	19	1	0.195	1.000	1.000
184	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	CARM1(5), DHRS1(2), DHRS3(2), DHRS7(6), DHRSX(5), HEMK1(1), LCMT1(1), LCMT2(11), METTL6(3), PRMT2(8), PRMT3(5), PRMT5(3), PRMT6(4), PRMT7(6), PRMT8(9), WBSCR22(6)	6443426	77	46	72	23	19	20	3	11	22	2	0.319	1.000	1.000
185	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD28(1), CD86(6), HLA-DRA(8), IFNG(2), IFNGR1(6), IFNGR2(2), IL12A(2), IL12B(2), IL12RB1(5), IL12RB2(11), IL18(1), IL18R1(4), IL2RA(3), IL4(1), IL4R(3)	5432805	57	37	57	21	14	12	3	12	16	0	0.586	1.000	1.000
186	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	189	ACTB(8), ACTG1(1), ACTN1(7), ACTN2(23), ACTN4(11), AKT1(3), AKT2(8), AKT3(6), ARHGAP5(18), BAD(3), BCAR1(8), BCL2(3), BIRC2(3), BIRC3(6), BRAF(16), CAPN2(8), CAV1(4), CAV2(2), CAV3(2), CCND1(1), CCND2(3), CCND3(2), CDC42(1), CHAD(6), COL11A1(34), COL11A2(16), COL1A1(12), COL1A2(30), COL2A1(16), COL3A1(12), COL4A1(29), COL4A2(13), COL4A4(15), COL4A6(9), COL5A1(29), COL5A2(17), COL5A3(15), COL6A1(9), COL6A2(19), COL6A3(41), COL6A6(34), COMP(3), CRKL(1), CTNNB1(22), DIAPH1(11), DOCK1(17), EGF(10), EGFR(15), ELK1(3), ERBB2(15), FARP2(4), FIGF(4), FLNA(26), FLNB(32), FLNC(26), FLT1(16), FN1(29), FYN(10), GRB2(4), GSK3B(5), HGF(15), IBSP(2), IGF1(4), IGF1R(16), ILK(8), ITGA1(8), ITGA10(9), ITGA11(10), ITGA2(8), ITGA2B(9), ITGA3(11), ITGA4(12), ITGA5(5), ITGA6(6), ITGA7(16), ITGA8(6), ITGA9(8), ITGAV(13), ITGB1(10), ITGB3(7), ITGB4(18), ITGB5(7), ITGB6(4), ITGB7(6), ITGB8(14), JUN(4), KDR(13), LAMA1(45), LAMA2(33), LAMA3(24), LAMA4(26), LAMA5(29), LAMB1(18), LAMB2(24), LAMB3(20), LAMB4(19), LAMC1(21), LAMC2(12), LAMC3(18), MAP2K1(5), MAPK1(3), MAPK10(5), MAPK3(1), MAPK8(5), MAPK9(3), MET(8), MYL2(8), MYL7(1), MYL9(2), MYLK(22), MYLK2(4), PAK1(5), PAK2(7), PAK3(5), PAK4(8), PAK6(9), PAK7(9), PARVA(2), PARVB(4), PARVG(3), PDGFA(2), PDGFB(4), PDGFC(7), PDGFD(9), PDGFRA(11), PDGFRB(14), PDPK1(2), PGF(1), PIK3CB(13), PIK3CD(11), PIK3CG(21), PIK3R1(11), PIK3R2(11), PIK3R3(8), PIK3R5(8), PIP5K1C(11), PPP1CA(2), PPP1CB(1), PPP1CC(5), PPP1R12A(2), PRKCA(5), PRKCG(17), PTK2(11), PXN(4), RAC2(2), RAC3(4), RAF1(10), RAP1A(2), RAP1B(6), RAPGEF1(9), RELN(47), ROCK1(18), ROCK2(12), SHC1(7), SHC2(2), SHC3(10), SHC4(4), SOS1(7), SOS2(19), SPP1(4), SRC(3), THBS1(16), THBS2(15), THBS3(9), THBS4(13), TLN1(23), TLN2(27), TNC(25), TNN(22), TNR(23), TNXB(43), VASP(2), VAV1(9), VAV2(12), VAV3(10), VCL(6), VEGFB(1), VEGFC(9), VTN(8), VWF(28), ZYX(7)	157862481	2078	246	1990	752	646	480	71	426	426	29	0.438	1.000	1.000
187	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	165	ADCY1(19), ADCY2(17), ADCY3(12), ADCY4(9), ADCY7(16), ADCY8(31), ADCY9(13), ADORA2A(1), ADORA2B(1), ADRA1A(16), ADRA1B(5), ADRA1D(4), ADRB1(7), ADRB2(8), ADRB3(5), AGTR1(2), ATP2A1(16), ATP2A2(5), ATP2A3(6), ATP2B1(12), ATP2B2(18), ATP2B3(21), ATP2B4(8), AVPR1A(14), AVPR1B(3), BDKRB1(2), BDKRB2(4), BST1(3), CACNA1A(24), CACNA1B(24), CACNA1C(37), CACNA1D(35), CACNA1E(44), CACNA1F(11), CACNA1G(23), CACNA1H(25), CACNA1I(18), CACNA1S(17), CALM1(2), CALM2(2), CALML3(1), CAMK2A(3), CAMK2B(4), CAMK2D(3), CAMK2G(8), CAMK4(8), CCKAR(5), CCKBR(9), CD38(4), CHRM1(4), CHRM2(17), CHRM3(11), CHRM5(2), CHRNA7(4), CYSLTR1(6), CYSLTR2(1), DRD1(3), EDNRA(4), EGFR(15), ERBB2(15), ERBB4(48), F2R(3), GNA11(6), GNA14(4), GNA15(3), GNAL(2), GNAQ(4), GNAS(29), GRIN1(8), GRIN2A(16), GRIN2C(6), GRIN2D(7), GRM1(31), GRM5(26), GRPR(6), HRH1(5), HRH2(8), HTR2A(6), HTR2B(5), HTR2C(6), HTR4(5), HTR5A(9), HTR6(7), HTR7(10), ITPKA(2), ITPKB(11), ITPR1(24), ITPR2(30), ITPR3(36), LHCGR(11), LTB4R2(4), MYLK(22), MYLK2(4), NOS1(28), NOS3(10), NTSR1(7), OXTR(7), P2RX1(3), P2RX2(7), P2RX3(6), P2RX4(6), P2RX5(5), P2RX7(1), PDE1A(7), PDE1B(6), PDE1C(11), PDGFRA(11), PDGFRB(14), PHKA1(10), PHKA2(10), PHKB(6), PHKG1(2), PLCB1(19), PLCB2(8), PLCB3(12), PLCB4(13), PLCD1(4), PLCD3(9), PLCD4(5), PLCE1(14), PLCG1(19), PLCG2(15), PLCZ1(6), PPID(3), PPP3CA(10), PPP3CB(6), PPP3CC(5), PPP3R1(2), PRKACA(4), PRKACB(4), PRKACG(8), PRKCA(5), PRKCG(17), PRKX(5), PTAFR(5), PTGER3(5), PTGFR(5), PTK2B(16), RYR1(61), RYR2(82), RYR3(68), SLC25A4(3), SLC25A5(3), SLC25A6(5), SLC8A1(14), SLC8A2(13), SLC8A3(9), SPHK1(6), SPHK2(3), TACR1(3), TACR2(1), TACR3(15), TBXA2R(8), TNNC1(3), TRHR(5), TRPC1(8), VDAC1(3), VDAC2(1), VDAC3(3)	113564038	1769	239	1697	613	655	404	75	337	288	10	0.0111	1.000	1.000
188	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	233	ADCYAP1R1(7), ADORA1(5), ADORA2A(1), ADORA2B(1), ADORA3(5), ADRA1A(16), ADRA1B(5), ADRA2A(7), ADRA2B(7), ADRA2C(5), ADRB1(7), ADRB2(8), ADRB3(5), AGTR1(2), AGTR2(4), AVPR1A(14), AVPR1B(3), AVPR2(6), BDKRB1(2), BDKRB2(4), BRS3(3), C3AR1(8), C5AR1(5), CALCR(6), CALCRL(8), CCKAR(5), CCKBR(9), CGA(1), CHRM1(4), CHRM2(17), CHRM3(11), CHRM4(2), CHRM5(2), CNR1(11), CRHR1(11), CRHR2(4), CTSG(3), CYSLTR1(6), CYSLTR2(1), DRD1(3), DRD2(9), DRD3(7), DRD4(3), DRD5(10), EDNRA(4), F2(9), F2R(3), F2RL1(2), F2RL2(3), F2RL3(3), FPR1(6), FSHB(1), GABBR1(16), GABBR2(11), GABRA1(14), GABRA2(9), GABRA3(10), GABRA4(9), GABRA5(7), GABRA6(10), GABRB1(8), GABRB2(5), GABRB3(9), GABRD(7), GABRE(7), GABRG1(4), GABRG2(13), GABRG3(6), GABRP(4), GABRQ(12), GABRR1(6), GABRR2(4), GALR1(6), GALR2(10), GALR3(2), GH1(2), GH2(1), GHR(6), GHRHR(4), GHSR(9), GIPR(4), GLP1R(1), GLP2R(8), GLRA1(4), GLRA2(5), GLRA3(6), GLRB(8), GNRHR(4), GPR156(5), GPR35(4), GPR50(11), GPR63(2), GPR83(5), GRIA1(20), GRIA2(23), GRIA3(8), GRIA4(10), GRID1(24), GRID2(16), GRIK1(11), GRIK2(18), GRIK3(16), GRIK4(14), GRIK5(10), GRIN1(8), GRIN2A(16), GRIN2B(23), GRIN2C(6), GRIN2D(7), GRIN3A(18), GRIN3B(6), GRM1(31), GRM2(23), GRM3(17), GRM4(11), GRM5(26), GRM6(10), GRM7(20), GRM8(22), GRPR(6), GZMA(3), HCRTR1(5), HCRTR2(10), HRH1(5), HRH2(8), HRH3(5), HRH4(3), HTR1A(11), HTR1B(10), HTR1D(4), HTR1E(10), HTR1F(8), HTR2A(6), HTR2B(5), HTR2C(6), HTR4(5), HTR5A(9), HTR6(7), HTR7(10), LEP(2), LEPR(13), LHB(1), LHCGR(11), LTB4R(2), LTB4R2(4), MAS1(2), MC1R(6), MC2R(2), MC3R(9), MC4R(5), MC5R(5), MCHR1(6), MCHR2(4), MLNR(4), MTNR1A(5), MTNR1B(6), NMBR(4), NMUR1(5), NMUR2(5), NPBWR1(13), NPBWR2(8), NPFFR1(1), NPFFR2(10), NPY1R(4), NPY2R(6), NPY5R(4), NR3C1(6), NTSR1(7), NTSR2(4), OPRD1(2), OPRK1(14), OPRL1(6), OPRM1(4), OXTR(7), P2RX1(3), P2RX2(7), P2RX3(6), P2RX4(6), P2RX5(5), P2RX7(1), P2RY1(3), P2RY10(10), P2RY13(4), P2RY14(4), P2RY2(5), P2RY4(5), P2RY6(8), P2RY8(7), PARD3(11), PRL(1), PRLHR(7), PRLR(4), PRSS1(1), PRSS3(3), PTAFR(5), PTGDR(7), PTGER2(5), PTGER3(5), PTGER4(8), PTGFR(5), PTH2R(8), RXFP1(9), RXFP2(10), SCTR(3), SSTR1(9), SSTR2(4), SSTR3(8), SSTR4(14), SSTR5(4), TAAR1(4), TAAR2(3), TAAR5(6), TAAR6(7), TACR1(3), TACR2(1), TACR3(15), TBXA2R(8), THRA(6), THRB(9), TRHR(5), TRPV1(8), TSHB(3), TSHR(10), UTS2R(3), VIPR1(3), VIPR2(3)	94196153	1621	227	1570	553	598	362	68	379	211	3	0.00114	1.000	1.000
189	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	136	ACTB(8), ACTG1(1), CHAD(6), COL11A1(34), COL11A2(16), COL17A1(10), COL1A1(12), COL1A2(30), COL2A1(16), COL3A1(12), COL4A1(29), COL4A2(13), COL4A4(15), COL4A6(9), COL5A1(29), COL5A2(17), COL5A3(15), COL6A1(9), COL6A2(19), COL6A3(41), COL6A6(34), COMP(3), DES(1), DSC1(2), DSC2(12), DSC3(5), DSG1(5), DSG2(6), DSG3(10), DSG4(8), FN1(29), GJA1(11), GJA10(3), GJA3(2), GJA4(4), GJA5(8), GJA8(8), GJA9(3), GJB1(1), GJB3(4), GJB4(4), GJB5(2), GJB6(5), GJB7(2), GJC1(3), GJC2(3), GJD2(5), GJD4(6), IBSP(2), INA(7), ITGA6(6), ITGB4(18), KRT1(6), KRT10(6), KRT12(3), KRT13(9), KRT14(2), KRT15(3), KRT16(8), KRT17(5), KRT18(2), KRT19(2), KRT2(10), KRT20(4), KRT23(11), KRT24(6), KRT25(7), KRT27(8), KRT28(10), KRT3(8), KRT31(6), KRT32(7), KRT33A(9), KRT33B(4), KRT34(6), KRT35(4), KRT36(6), KRT37(3), KRT38(4), KRT39(8), KRT4(7), KRT40(1), KRT5(4), KRT6A(9), KRT6B(3), KRT6C(7), KRT7(3), KRT71(2), KRT72(6), KRT73(15), KRT74(4), KRT75(5), KRT76(4), KRT77(2), KRT78(3), KRT79(5), KRT8(6), KRT81(3), KRT82(3), KRT83(3), KRT84(6), KRT85(3), KRT86(3), KRT9(1), LAMA1(45), LAMA2(33), LAMA3(24), LAMA4(26), LAMA5(29), LAMB1(18), LAMB2(24), LAMB3(20), LAMB4(19), LAMC1(21), LAMC2(12), LAMC3(18), LMNA(6), LMNB1(4), LMNB2(6), NES(12), PRPH(3), RELN(47), SPP1(4), THBS1(16), THBS2(15), THBS3(9), THBS4(13), TNC(25), TNN(22), TNR(23), TNXB(43), VIM(10), VTN(8), VWF(28)	107036911	1421	221	1387	574	435	324	55	320	271	16	0.971	1.000	1.000
190	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	240	ACVR1B(13), ACVR1C(5), AKT1(3), AKT2(8), AKT3(6), ARRB1(3), ARRB2(1), ATF2(3), ATF4(2), BDNF(8), BRAF(16), CACNA1A(24), CACNA1B(24), CACNA1C(37), CACNA1D(35), CACNA1E(44), CACNA1F(11), CACNA1G(23), CACNA1H(25), CACNA1I(18), CACNA1S(17), CACNA2D1(10), CACNA2D2(9), CACNA2D3(17), CACNA2D4(9), CACNB1(1), CACNB2(15), CACNB3(2), CACNB4(6), CACNG1(5), CACNG2(2), CACNG3(5), CACNG4(3), CACNG5(9), CACNG6(3), CACNG7(11), CACNG8(3), CASP3(2), CD14(2), CDC25B(4), CDC42(1), CHUK(4), CRKL(1), DAXX(10), DDIT3(4), DUSP1(2), DUSP10(8), DUSP14(3), DUSP16(9), DUSP2(2), DUSP3(1), DUSP4(1), DUSP5(8), DUSP6(3), DUSP8(1), DUSP9(5), ECSIT(4), EGF(10), EGFR(15), ELK1(3), ELK4(1), FAS(3), FASLG(3), FGF1(3), FGF10(5), FGF11(1), FGF12(8), FGF14(6), FGF16(1), FGF17(5), FGF18(2), FGF19(1), FGF2(2), FGF20(3), FGF21(1), FGF22(2), FGF23(2), FGF3(2), FGF5(5), FGF6(6), FGF7(1), FGF8(1), FGF9(6), FGFR1(13), FGFR2(11), FGFR3(6), FGFR4(9), FLNA(26), FLNB(32), FLNC(26), FOS(1), GADD45B(1), GNA12(1), GRB2(4), IKBKB(8), IL1A(2), IL1B(3), IL1R1(4), IL1R2(10), JUN(4), JUND(2), MAP2K1(5), MAP2K2(3), MAP2K3(4), MAP2K4(8), MAP2K5(1), MAP2K6(1), MAP3K1(11), MAP3K10(8), MAP3K12(15), MAP3K13(9), MAP3K2(4), MAP3K3(8), MAP3K4(21), MAP3K5(5), MAP3K6(8), MAP3K7(10), MAP4K1(4), MAP4K2(8), MAP4K3(4), MAP4K4(10), MAPK1(3), MAPK10(5), MAPK11(1), MAPK13(3), MAPK14(1), MAPK3(1), MAPK7(6), MAPK8(5), MAPK8IP1(4), MAPK8IP2(4), MAPK8IP3(13), MAPK9(3), MAPKAPK2(1), MAPKAPK3(5), MAPKAPK5(3), MAPT(7), MAX(3), MEF2C(4), MKNK1(3), MKNK2(7), MOS(11), MRAS(2), MYC(5), NF1(26), NFATC2(17), NFATC4(16), NFKB1(7), NFKB2(7), NR4A1(4), NRAS(3), NTF3(5), NTRK1(10), NTRK2(13), PAK1(5), PAK2(7), PDGFA(2), PDGFB(4), PDGFRA(11), PDGFRB(14), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G2A(2), PLA2G2D(1), PLA2G2E(4), PLA2G3(9), PLA2G4A(6), PLA2G5(1), PLA2G6(6), PPM1A(4), PPM1B(10), PPP3CA(10), PPP3CB(6), PPP3CC(5), PPP3R1(2), PPP5C(8), PRKACA(4), PRKACB(4), PRKACG(8), PRKCA(5), PRKCG(17), PRKX(5), PTPN5(6), PTPN7(7), PTPRR(11), RAC2(2), RAC3(4), RAF1(10), RAP1A(2), RAP1B(6), RAPGEF2(14), RASA1(17), RASA2(8), RASGRF1(16), RASGRF2(12), RASGRP1(8), RASGRP2(7), RASGRP3(5), RASGRP4(4), RPS6KA1(9), RPS6KA2(9), RPS6KA3(4), RPS6KA4(6), RPS6KA5(3), RPS6KA6(15), RRAS(1), RRAS2(3), SOS1(7), SOS2(19), SRF(2), STK3(5), STK4(3), STMN1(2), TAOK1(11), TAOK2(19), TAOK3(11), TGFB1(3), TGFB2(6), TGFB3(8), TGFBR1(4), TGFBR2(14), TNF(3), TNFRSF1A(6), TRAF2(4), TRAF6(6), ZAK(9)	120700455	1623	220	1555	507	550	369	62	279	345	18	0.000766	1.000	1.000
191	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	198	ABI2(6), ACTN1(7), ACTN2(23), ACTN4(11), APC(43), APC2(15), ARAF(11), ARHGEF1(11), ARHGEF12(14), ARHGEF4(8), ARHGEF6(13), ARHGEF7(8), ARPC1A(3), ARPC2(3), ARPC4(2), ARPC5L(1), BAIAP2(5), BCAR1(8), BDKRB1(2), BDKRB2(4), BRAF(16), CD14(2), CDC42(1), CFL1(1), CFL2(1), CHRM1(4), CHRM2(17), CHRM3(11), CHRM4(2), CHRM5(2), CRKL(1), CSK(7), CYFIP1(11), CYFIP2(16), DIAPH1(11), DIAPH2(7), DIAPH3(13), DOCK1(17), EGF(10), EGFR(15), EZR(6), F2(9), F2R(3), FGD1(12), FGD3(12), FGF1(3), FGF10(5), FGF11(1), FGF12(8), FGF14(6), FGF16(1), FGF17(5), FGF18(2), FGF19(1), FGF2(2), FGF20(3), FGF21(1), FGF22(2), FGF23(2), FGF3(2), FGF5(5), FGF6(6), FGF7(1), FGF8(1), FGF9(6), FGFR1(13), FGFR2(11), FGFR3(6), FGFR4(9), FN1(29), GIT1(3), GNA12(1), GNA13(5), GSN(11), IQGAP1(14), IQGAP2(10), IQGAP3(14), ITGA1(8), ITGA10(9), ITGA11(10), ITGA2(8), ITGA2B(9), ITGA3(11), ITGA4(12), ITGA5(5), ITGA6(6), ITGA7(16), ITGA8(6), ITGA9(8), ITGAD(12), ITGAE(12), ITGAL(16), ITGAM(9), ITGAV(13), ITGAX(14), ITGB1(10), ITGB2(6), ITGB3(7), ITGB4(18), ITGB5(7), ITGB6(4), ITGB7(6), ITGB8(14), LIMK1(5), LIMK2(2), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK3(1), MOS(11), MRAS(2), MSN(9), MYH10(36), MYH14(18), MYH9(34), MYL2(8), MYL7(1), MYL9(2), MYLK(22), MYLK2(4), NCKAP1(9), NCKAP1L(14), NRAS(3), PAK1(5), PAK2(7), PAK3(5), PAK4(8), PAK6(9), PAK7(9), PDGFA(2), PDGFB(4), PDGFRA(11), PDGFRB(14), PFN2(2), PFN3(3), PFN4(1), PIK3CB(13), PIK3CD(11), PIK3CG(21), PIK3R1(11), PIK3R2(11), PIK3R3(8), PIK3R5(8), PIP4K2A(6), PIP4K2B(4), PIP4K2C(2), PIP5K1A(4), PIP5K1B(1), PIP5K1C(11), PPP1CA(2), PPP1CB(1), PPP1CC(5), PPP1R12A(2), PPP1R12B(15), PTK2(11), PXN(4), RAC2(2), RAC3(4), RAF1(10), RDX(7), ROCK1(18), ROCK2(12), RRAS(1), RRAS2(3), SCIN(6), SLC9A1(10), SOS1(7), SOS2(19), SSH1(9), SSH2(22), SSH3(8), TIAM1(32), TIAM2(23), VAV1(9), VAV2(12), VAV3(10), VCL(6), WAS(3), WASF1(5), WASF2(5), WASL(3)	116837455	1519	219	1466	535	507	337	54	293	304	24	0.429	1.000	1.000
192	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	136	ADCY1(19), ADCY2(17), ADCY3(12), ADCY4(9), ADCY5(13), ADCY6(14), ADCY7(16), ADCY8(31), ADCY9(13), ADRA1A(16), ADRA1B(5), ADRA1D(4), ADRB1(7), ADRB2(8), ADRB3(5), ANXA6(2), ARRB1(3), ARRB2(1), ATP1A4(19), ATP1B1(6), ATP1B2(3), ATP1B3(4), ATP2A2(5), ATP2A3(6), ATP2B1(12), ATP2B2(18), ATP2B3(21), CACNA1A(24), CACNA1B(24), CACNA1C(37), CACNA1D(35), CACNA1E(44), CACNA1S(17), CACNB1(1), CACNB3(2), CALM1(2), CALM2(2), CALR(5), CAMK1(3), CAMK2A(3), CAMK2B(4), CAMK2D(3), CAMK2G(8), CAMK4(8), CASQ1(6), CASQ2(3), CHRM1(4), CHRM2(17), CHRM3(11), CHRM4(2), CHRM5(2), GJA1(11), GJA4(4), GJA5(8), GJB1(1), GJB3(4), GJB4(4), GJB5(2), GJB6(5), GNA11(6), GNAI2(3), GNAI3(7), GNAO1(1), GNAQ(4), GNAZ(17), GNB1(1), GNB2(3), GNB3(1), GNB4(3), GNB5(1), GNG13(2), GNGT1(3), GRK4(5), GRK5(1), GRK6(5), ITPR1(24), ITPR2(30), ITPR3(36), KCNB1(12), KCNJ5(5), MIB1(4), NME7(1), PKIA(2), PKIG(2), PLCB3(12), PRKACA(4), PRKACB(4), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), PRKCA(5), PRKCD(7), PRKCE(14), PRKCG(17), PRKCH(6), PRKCQ(10), PRKD1(20), RGS1(2), RGS10(3), RGS11(2), RGS14(3), RGS16(3), RGS17(4), RGS18(6), RGS19(3), RGS2(3), RGS20(6), RGS3(13), RGS4(6), RGS5(3), RGS6(14), RGS7(2), RGS9(10), RYR1(61), RYR2(82), RYR3(68), SFN(1), SLC8A1(14), SLC8A3(9), USP5(6), YWHAB(2), YWHAH(3), YWHAQ(2)	79896656	1223	214	1189	438	447	279	53	238	195	11	0.0714	1.000	1.000
193	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(15), CD36(2), CD44(5), CHAD(6), COL11A1(34), COL11A2(16), COL1A1(12), COL1A2(30), COL2A1(16), COL3A1(12), COL4A1(29), COL4A2(13), COL4A4(15), COL4A6(9), COL5A1(29), COL5A2(17), COL5A3(15), COL6A1(9), COL6A2(19), COL6A3(41), COL6A6(34), DAG1(13), FN1(29), FNDC1(15), FNDC3A(8), FNDC4(2), FNDC5(2), GP5(7), GP6(3), GP9(3), HMMR(7), HSPG2(35), IBSP(2), ITGA1(8), ITGA10(9), ITGA11(10), ITGA2(8), ITGA2B(9), ITGA3(11), ITGA4(12), ITGA5(5), ITGA6(6), ITGA7(16), ITGA8(6), ITGA9(8), ITGAV(13), ITGB1(10), ITGB3(7), ITGB4(18), ITGB5(7), ITGB6(4), ITGB7(6), ITGB8(14), LAMA1(45), LAMA2(33), LAMA3(24), LAMA4(26), LAMA5(29), LAMB1(18), LAMB2(24), LAMB3(20), LAMB4(19), LAMC1(21), LAMC2(12), LAMC3(18), RELN(47), SDC1(2), SDC2(2), SDC3(5), SDC4(3), SPP1(4), SV2A(13), SV2B(5), SV2C(9), THBS1(16), THBS2(15), THBS3(9), THBS4(13), TNC(25), TNN(22), TNR(23), TNXB(43), VTN(8), VWF(28)	96226801	1272	214	1229	489	395	271	44	288	256	18	0.828	1.000	1.000
194	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	128	ACTB(8), ACTG1(1), ACTN1(7), ACTN2(23), ACTN4(11), AKT1(3), AKT2(8), AKT3(6), AMOTL1(8), ASH1L(39), CASK(6), CDC42(1), CGN(12), CLDN1(3), CLDN10(2), CLDN11(1), CLDN14(3), CLDN15(1), CLDN16(4), CLDN17(6), CLDN18(2), CLDN19(6), CLDN2(1), CLDN20(4), CLDN22(3), CLDN23(3), CLDN3(1), CLDN4(6), CLDN5(2), CLDN6(7), CLDN8(2), CLDN9(7), CSNK2A1(5), CSNK2A2(6), CSNK2B(1), CTNNA1(15), CTNNA2(19), CTNNA3(16), CTNNB1(22), CTTN(7), EPB41(11), EPB41L1(6), EPB41L2(9), EPB41L3(27), EXOC3(3), EXOC4(8), F11R(2), GNAI1(1), GNAI2(3), GNAI3(7), HCLS1(3), IGSF5(3), INADL(16), JAM2(2), JAM3(7), LLGL1(9), LLGL2(6), MAGI1(20), MAGI2(27), MAGI3(9), MLLT4(24), MPDZ(23), MPP5(2), MRAS(2), MYH1(20), MYH10(36), MYH11(29), MYH13(23), MYH14(18), MYH15(17), MYH2(29), MYH3(27), MYH4(22), MYH6(27), MYH7(23), MYH7B(18), MYH8(18), MYH9(34), MYL2(8), MYL7(1), MYL9(2), NRAS(3), OCLN(6), PARD3(11), PARD6A(1), PARD6B(3), PARD6G(3), PPM1J(2), PPP2CA(4), PPP2CB(3), PPP2R1A(11), PPP2R1B(6), PPP2R2A(6), PPP2R2B(8), PPP2R2C(8), PPP2R3A(9), PPP2R3B(15), PPP2R4(4), PRKCA(5), PRKCD(7), PRKCE(14), PRKCG(17), PRKCH(6), PRKCI(8), PRKCQ(10), RAB13(2), RAB3B(3), RRAS(1), RRAS2(3), SPTAN1(21), SRC(3), SYMPK(7), TJAP1(2), TJP1(21), TJP2(15), TJP3(11), VAPA(3), YES1(2), ZAK(9)	82619342	1143	207	1105	353	372	261	39	247	215	9	0.0177	1.000	1.000
195	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	124	ABL1(7), ABLIM1(12), ABLIM2(11), ABLIM3(6), ARHGEF12(14), CDC42(1), CDK5(2), CFL1(1), CFL2(1), CXCR4(1), DCC(32), DPYSL2(2), DPYSL5(10), EFNA1(1), EFNA2(1), EFNA4(2), EFNA5(4), EFNB1(1), EFNB2(3), EFNB3(7), EPHA1(13), EPHA2(25), EPHA3(23), EPHA4(17), EPHA5(29), EPHA7(6), EPHA8(13), EPHB1(23), EPHB2(12), EPHB3(13), EPHB4(9), EPHB6(14), FES(11), FYN(10), GNAI1(1), GNAI2(3), GNAI3(7), GSK3B(5), ITGB1(10), L1CAM(16), LIMK1(5), LIMK2(2), LRRC4C(5), MAPK1(3), MAPK3(1), MET(8), NCK1(6), NCK2(5), NFAT5(10), NFATC1(13), NFATC2(17), NFATC3(4), NFATC4(16), NGEF(6), NRAS(3), NRP1(14), NTN1(7), NTN4(2), NTNG1(19), PAK1(5), PAK2(7), PAK3(5), PAK4(8), PAK6(9), PAK7(9), PLXNA1(33), PLXNA2(25), PLXNA3(20), PLXNB1(19), PLXNB2(17), PLXNB3(12), PLXNC1(20), PPP3CA(10), PPP3CB(6), PPP3CC(5), PPP3R1(2), PTK2(11), RAC2(2), RAC3(4), RASA1(17), RGS3(13), RHOD(2), RND1(3), ROBO1(30), ROBO2(33), ROBO3(11), ROCK1(18), ROCK2(12), SEMA3A(15), SEMA3C(7), SEMA3D(12), SEMA3E(12), SEMA3F(11), SEMA3G(5), SEMA4A(9), SEMA4B(3), SEMA4C(9), SEMA4D(15), SEMA4F(8), SEMA4G(4), SEMA5A(24), SEMA5B(20), SEMA6A(18), SEMA6B(6), SEMA6C(10), SEMA6D(20), SEMA7A(7), SLIT1(11), SLIT2(27), SLIT3(15), SRGAP1(12), SRGAP2(6), SRGAP3(13), UNC5A(10), UNC5B(10), UNC5C(16), UNC5D(16)	83217476	1244	206	1205	421	384	266	65	263	252	14	0.193	1.000	1.000
196	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	125	ALCAM(10), CADM3(11), CD2(3), CD22(5), CD226(2), CD274(2), CD276(6), CD28(1), CD34(4), CD40(3), CD40LG(5), CD58(6), CD6(9), CD80(4), CD86(6), CD8A(4), CD8B(1), CD99(1), CDH15(6), CDH2(19), CDH3(10), CDH4(22), CDH5(10), CLDN1(3), CLDN10(2), CLDN11(1), CLDN14(3), CLDN15(1), CLDN16(4), CLDN17(6), CLDN18(2), CLDN19(6), CLDN2(1), CLDN20(4), CLDN22(3), CLDN23(3), CLDN3(1), CLDN4(6), CLDN5(2), CLDN6(7), CLDN8(2), CLDN9(7), CNTN1(19), CNTN2(10), CNTNAP1(18), CNTNAP2(40), CTLA4(3), ESAM(5), F11R(2), GLG1(13), HLA-C(6), HLA-DMA(1), HLA-DMB(3), HLA-DOA(2), HLA-DOB(2), HLA-DPA1(2), HLA-DPB1(3), HLA-DQA1(1), HLA-DQA2(3), HLA-DQB1(1), HLA-DRA(8), HLA-E(5), HLA-F(7), HLA-G(5), ICAM1(2), ICAM2(3), ICAM3(1), ICOS(2), ICOSLG(2), ITGA4(12), ITGA6(6), ITGA8(6), ITGA9(8), ITGAL(16), ITGAM(9), ITGAV(13), ITGB1(10), ITGB2(6), ITGB7(6), ITGB8(14), JAM2(2), JAM3(7), L1CAM(16), MAG(14), MPZ(2), MPZL1(2), NCAM1(4), NCAM2(24), NEGR1(7), NEO1(14), NFASC(18), NLGN1(16), NLGN2(10), NLGN3(13), NRCAM(11), NRXN1(39), NRXN2(25), NRXN3(28), OCLN(6), PDCD1(2), PDCD1LG2(1), PTPRC(19), PTPRF(18), PTPRM(28), PVR(3), PVRL1(1), PVRL2(5), PVRL3(6), SDC1(2), SDC2(2), SDC3(5), SDC4(3), SELE(5), SELL(4), SELP(10), SELPLG(7), SIGLEC1(18), SPN(4), VCAM1(10), VCAN(41)	61274097	941	201	906	343	300	244	29	203	157	8	0.165	1.000	1.000
197	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	139	APC(43), APC2(15), AXIN1(9), AXIN2(15), BTRC(9), CACYBP(2), CAMK2A(3), CAMK2B(4), CAMK2D(3), CAMK2G(8), CCND1(1), CCND2(3), CCND3(2), CER1(2), CHD8(19), CREBBP(40), CSNK1A1(3), CSNK1A1L(6), CSNK1E(8), CSNK2A1(5), CSNK2A2(6), CSNK2B(1), CTBP1(3), CTBP2(8), CTNNB1(22), CTNNBIP1(1), CUL1(22), CXXC4(2), DAAM1(11), DAAM2(13), DKK1(9), DKK2(5), DKK4(3), DVL1(7), DVL2(6), DVL3(12), EP300(22), FBXW11(10), FOSL1(1), FZD1(10), FZD10(18), FZD2(7), FZD3(11), FZD4(6), FZD5(4), FZD6(9), FZD7(7), FZD8(10), FZD9(2), GSK3B(5), JUN(4), LEF1(8), LRP5(22), LRP6(7), MAP3K7(10), MAPK10(5), MAPK8(5), MAPK9(3), MMP7(2), MYC(5), NFAT5(10), NFATC1(13), NFATC2(17), NFATC3(4), NFATC4(16), NKD1(10), NKD2(1), PLCB1(19), PLCB2(8), PLCB3(12), PLCB4(13), PORCN(5), PPARD(8), PPP2CA(4), PPP2CB(3), PPP2R1A(11), PPP2R1B(6), PPP2R2A(6), PPP2R2B(8), PPP2R2C(8), PPP3CA(10), PPP3CB(6), PPP3CC(5), PPP3R1(2), PRICKLE1(16), PRICKLE2(16), PRKACA(4), PRKACB(4), PRKACG(8), PRKCA(5), PRKCG(17), PRKX(5), PSEN1(3), RAC2(2), RAC3(4), RBX1(1), ROCK1(18), ROCK2(12), RUVBL1(8), SENP2(4), SFRP1(4), SFRP2(6), SFRP4(5), SFRP5(1), SIAH1(2), SMAD2(9), SMAD3(5), SOX17(11), TBL1X(6), TBL1XR1(6), TBL1Y(1), TCF7(8), TCF7L1(5), TCF7L2(11), VANGL1(2), VANGL2(9), WIF1(2), WNT1(8), WNT10A(5), WNT10B(2), WNT11(2), WNT2(4), WNT2B(10), WNT3(5), WNT3A(6), WNT4(2), WNT5A(6), WNT5B(4), WNT6(3), WNT7A(5), WNT7B(7), WNT8A(1), WNT8B(1), WNT9A(8), WNT9B(4)	67539649	1032	198	983	300	355	238	27	165	232	15	0.000181	1.000	1.000
198	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	135	ACTA1(3), ACTA2(6), ADCY1(19), ADCY2(17), ADCY3(12), ADCY4(9), ADCY5(13), ADCY6(14), ADCY7(16), ADCY8(31), ADCY9(13), ADM(2), ARRB1(3), ARRB2(1), ATF2(3), ATF3(1), ATF4(2), ATF5(3), ATP2A2(5), ATP2A3(6), CACNB3(2), CALCA(2), CALM1(2), CALM2(2), CAMK2A(3), CAMK2B(4), CAMK2D(3), CAMK2G(8), CNN1(3), CNN2(1), CORIN(13), CRHR1(11), DGKZ(8), ETS2(4), FOS(1), GABPA(2), GABPB2(3), GBA2(4), GJA1(11), GNAQ(4), GNB1(1), GNB2(3), GNB3(1), GNB4(3), GNB5(1), GNG13(2), GNGT1(3), GRK4(5), GRK5(1), GRK6(5), GUCA2A(1), GUCA2B(1), GUCY1A3(15), IGFBP2(5), IGFBP3(6), IGFBP4(1), IGFBP6(1), IL1B(3), ITPR1(24), ITPR2(30), ITPR3(36), JUN(4), MAFF(1), MIB1(4), MYL2(8), MYLK2(4), NFKB1(7), NOS1(28), NOS3(10), OXT(1), OXTR(7), PDE4B(5), PDE4D(4), PKIA(2), PKIG(2), PLCB3(12), PLCD1(4), PLCG1(19), PLCG2(15), PRKACA(4), PRKACB(4), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), PRKCA(5), PRKCD(7), PRKCE(14), PRKCH(6), PRKCQ(10), PRKD1(20), RAMP2(2), RAMP3(3), RGS1(2), RGS10(3), RGS11(2), RGS14(3), RGS16(3), RGS17(4), RGS18(6), RGS19(3), RGS2(3), RGS20(6), RGS3(13), RGS4(6), RGS5(3), RGS6(14), RGS7(2), RGS9(10), RLN1(3), RYR1(61), RYR2(82), RYR3(68), SFN(1), SLC8A1(14), SP1(6), TNXB(43), USP5(6), YWHAB(2), YWHAH(3), YWHAQ(2)	74010410	1023	193	993	376	361	214	44	221	173	10	0.335	1.000	1.000
199	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	249	ACVR1(5), ACVR1B(13), ACVR2A(8), ACVR2B(5), AMHR2(4), BMP2(5), BMP7(7), BMPR1A(5), BMPR1B(7), BMPR2(16), CCL1(2), CCL11(1), CCL15(2), CCL16(1), CCL18(2), CCL19(2), CCL2(1), CCL20(2), CCL22(1), CCL23(1), CCL24(1), CCL25(1), CCL27(1), CCL3(1), CCL5(2), CCL7(1), CCL8(2), CCR1(5), CCR2(6), CCR3(6), CCR5(4), CCR6(1), CCR7(3), CCR8(3), CCR9(3), CD27(2), CD40(3), CD40LG(5), CD70(2), CLCF1(2), CNTF(3), CNTFR(3), CRLF2(2), CSF1(2), CSF1R(15), CSF2RA(9), CSF2RB(9), CSF3(2), CSF3R(13), CX3CL1(7), CX3CR1(3), CXCL10(1), CXCL2(2), CXCL9(2), CXCR3(1), CXCR4(1), CXCR6(2), EDA(2), EDA2R(3), EDAR(9), EGF(10), EGFR(15), EPO(1), EPOR(3), FAS(3), FASLG(3), FLT1(16), FLT3(10), FLT3LG(1), FLT4(24), GDF5(11), GH1(2), GH2(1), GHR(6), HGF(15), IFNA1(1), IFNA10(4), IFNA13(1), IFNA16(4), IFNA2(1), IFNA4(1), IFNA5(2), IFNA6(3), IFNA7(4), IFNA8(1), IFNAR1(8), IFNAR2(6), IFNB1(3), IFNG(2), IFNGR1(6), IFNGR2(2), IFNK(1), IFNW1(4), IL10(2), IL10RA(5), IL10RB(3), IL11(3), IL11RA(3), IL12A(2), IL12B(2), IL12RB1(5), IL12RB2(11), IL13(2), IL13RA1(4), IL15RA(3), IL17B(4), IL17RA(7), IL17RB(6), IL18(1), IL18R1(4), IL18RAP(2), IL19(1), IL1A(2), IL1B(3), IL1R1(4), IL1R2(10), IL1RAP(7), IL20(1), IL20RA(8), IL21(4), IL21R(9), IL22(1), IL22RA1(2), IL22RA2(1), IL23A(3), IL23R(7), IL25(4), IL26(4), IL2RA(3), IL2RB(2), IL2RG(6), IL3(1), IL3RA(5), IL4(1), IL4R(3), IL5RA(4), IL6R(2), IL6ST(6), IL7(1), IL7R(9), IL9R(2), INHBA(12), INHBB(10), INHBC(6), INHBE(2), KDR(13), KIT(12), KITLG(3), LEP(2), LEPR(13), LIF(2), LIFR(13), LTA(4), LTBR(2), MET(8), MPL(5), NGFR(4), OSM(5), OSMR(8), PDGFB(4), PDGFC(7), PDGFRA(11), PDGFRB(14), PF4V1(1), PLEKHO2(3), PRL(1), PRLR(4), RELT(6), TGFB1(3), TGFB2(6), TGFB3(8), TGFBR1(4), TGFBR2(14), TNF(3), TNFRSF10A(1), TNFRSF10B(2), TNFRSF10C(3), TNFRSF10D(3), TNFRSF11A(5), TNFRSF11B(3), TNFRSF13B(5), TNFRSF13C(4), TNFRSF14(1), TNFRSF17(1), TNFRSF19(9), TNFRSF1A(6), TNFRSF1B(3), TNFRSF21(5), TNFRSF25(4), TNFRSF4(3), TNFRSF8(4), TNFRSF9(11), TNFSF10(5), TNFSF11(4), TNFSF13(3), TNFSF13B(4), TNFSF14(3), TNFSF15(2), TNFSF18(2), TNFSF4(1), TNFSF8(3), TPO(24), TSLP(1), VEGFB(1), VEGFC(9), XCL1(1), XCR1(4)	75871830	948	191	912	328	260	235	36	203	206	8	0.271	1.000	1.000
200	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(3), ACTA2(6), ACTN2(23), ACTN4(11), DES(1), DMD(62), MYBPC1(7), MYBPC2(10), MYBPC3(6), MYH3(27), MYH6(27), MYH7(23), MYH8(18), MYL1(1), MYL2(8), MYL3(3), MYL9(2), MYOM1(11), NEB(63), TMOD1(4), TNNI1(2), TNNI2(6), TNNT1(5), TNNT2(2), TNNT3(2), TPM1(4), TPM3(3), TPM4(3), TTN(480), VIM(10)	58405619	833	191	816	247	219	219	47	251	81	16	0.00889	1.000	1.000
201	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	159	ADORA1(5), ADORA2A(1), ADORA2B(1), ADORA3(5), ADRA1A(16), ADRA1B(5), ADRA1D(4), ADRA2A(7), ADRA2C(5), ADRB1(7), ADRB2(8), ADRB3(5), AGTR1(2), AGTR2(4), AVPR1A(14), AVPR1B(3), AVPR2(6), BDKRB1(2), BDKRB2(4), BRS3(3), C3AR1(8), CCKAR(5), CCKBR(9), CCR1(5), CCR10(1), CCR2(6), CCR3(6), CCR5(4), CCR6(1), CCR7(3), CCR8(3), CCR9(3), CCRL2(1), CHML(4), CHRM1(4), CHRM2(17), CHRM3(11), CHRM4(2), CHRM5(2), CMKLR1(4), CNR1(11), CX3CR1(3), CXCR3(1), CXCR4(1), DRD1(3), DRD2(9), DRD3(7), DRD4(3), DRD5(10), EDNRA(4), F2R(3), F2RL1(2), F2RL2(3), F2RL3(3), FPR1(6), GALR1(6), GALR2(10), GALR3(2), GALT(1), GHSR(9), GNB2L1(4), GPR17(5), GPR173(5), GPR174(3), GPR27(5), GPR3(4), GPR35(4), GPR37(10), GPR37L1(5), GPR4(3), GPR50(11), GPR6(11), GPR63(2), GPR83(5), GPR85(4), GPR87(5), GRPR(6), HCRTR1(5), HCRTR2(10), HRH1(5), HRH2(8), HRH3(5), HTR1A(11), HTR1B(10), HTR1D(4), HTR1E(10), HTR1F(8), HTR2A(6), HTR2B(5), HTR2C(6), HTR4(5), HTR5A(9), HTR6(7), HTR7(10), LHCGR(11), LTB4R(2), MAS1(2), MC1R(6), MC3R(9), MC4R(5), MC5R(5), MLNR(4), MTNR1A(5), MTNR1B(6), NMBR(4), NMUR1(5), NMUR2(5), NPY1R(4), NPY2R(6), NPY5R(4), NTSR1(7), NTSR2(4), OPN1SW(1), OPN3(4), OPRD1(2), OPRK1(14), OPRL1(6), OPRM1(4), OR10A5(5), OR11A1(5), OR12D3(4), OR1C1(5), OR1F1(4), OR1Q1(5), OR2H1(2), OR5V1(7), OR7C1(6), OR8B8(5), OXTR(7), P2RY1(3), P2RY10(10), P2RY12(6), P2RY13(4), P2RY14(4), P2RY2(5), P2RY6(8), PTAFR(5), PTGDR(7), PTGER2(5), PTGER4(8), PTGFR(5), RGR(3), RHO(7), RRH(3), SSTR1(9), SSTR2(4), SSTR3(8), SSTR4(14), SUCNR1(4), TBXA2R(8), TRHR(5)	51266770	834	187	807	317	314	203	33	174	107	3	0.0969	1.000	1.000
202	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	141	ADA(5), ADCY1(19), ADCY2(17), ADCY3(12), ADCY4(9), ADCY5(13), ADCY6(14), ADCY7(16), ADCY8(31), ADCY9(13), ADK(4), ADSL(5), ADSS(5), ADSSL1(8), AK1(1), AK5(4), AK7(4), ALLC(5), AMPD1(9), AMPD2(13), AMPD3(20), APRT(3), ATIC(6), CANT1(4), DGUOK(2), ENPP1(7), ENPP3(8), ENTPD1(5), ENTPD2(4), ENTPD3(5), ENTPD4(8), ENTPD5(3), ENTPD6(4), ENTPD8(6), GART(9), GDA(4), GMPR(1), GMPR2(3), GMPS(7), GUCY1A2(10), GUCY1A3(15), GUCY1B3(8), GUCY2C(12), GUCY2D(12), GUCY2F(15), GUK1(4), IMPDH1(5), ITPA(1), NME2(3), NME6(3), NME7(1), NPR1(11), NPR2(8), NT5C(1), NT5C1A(5), NT5C1B(6), NT5C2(8), NT5E(2), NUDT2(4), NUDT9(2), PAICS(1), PAPSS1(6), PAPSS2(5), PDE10A(13), PDE11A(8), PDE1A(7), PDE1C(11), PDE2A(15), PDE3B(20), PDE4A(7), PDE4B(5), PDE4C(6), PDE4D(4), PDE5A(7), PDE6D(1), PDE6G(1), PDE7A(5), PDE7B(3), PDE8A(10), PDE8B(5), PDE9A(7), PFAS(9), PKLR(7), PNPT1(5), POLA1(6), POLA2(4), POLD1(15), POLD2(4), POLD3(7), POLE(24), POLE2(4), POLE3(3), POLR1A(15), POLR1B(8), POLR1C(3), POLR1D(4), POLR2A(19), POLR2B(11), POLR2C(4), POLR2E(2), POLR2F(4), POLR2G(1), POLR2I(2), POLR2K(1), POLR3A(17), POLR3B(13), POLR3G(2), POLR3K(1), PPAT(5), PRIM1(2), PRIM2(1), PRPS1(3), PRPS1L1(2), PRPS2(3), PRUNE(4), RFC5(1), RRM1(5), RRM2(4), RRM2B(4), XDH(14), ZNRD1(1)	69850220	843	181	822	282	264	212	28	176	157	6	0.195	1.000	1.000
203	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	91	ADCY1(19), ADCY2(17), ADCY3(12), ADCY4(9), ADCY5(13), ADCY6(14), ADCY7(16), ADCY8(31), ADCY9(13), ADRB1(7), CSNK1D(2), DRD1(3), DRD2(9), EGF(10), EGFR(15), GJA1(11), GJD2(5), GNA11(6), GNAI1(1), GNAI2(3), GNAI3(7), GNAQ(4), GNAS(29), GRB2(4), GRM1(31), GRM5(26), GUCY1A2(10), GUCY1A3(15), GUCY1B3(8), GUCY2C(12), GUCY2D(12), GUCY2F(15), HTR2A(6), HTR2B(5), HTR2C(6), ITPR1(24), ITPR2(30), ITPR3(36), MAP2K1(5), MAP2K2(3), MAP2K5(1), MAP3K2(4), MAPK1(3), MAPK3(1), MAPK7(6), NPR1(11), NPR2(8), NRAS(3), PDGFA(2), PDGFB(4), PDGFC(7), PDGFD(9), PDGFRA(11), PDGFRB(14), PLCB1(19), PLCB2(8), PLCB3(12), PLCB4(13), PRKACA(4), PRKACB(4), PRKACG(8), PRKCA(5), PRKCG(17), PRKG1(10), PRKG2(13), PRKX(5), RAF1(10), SOS1(7), SOS2(19), SRC(3), TJP1(21), TUBA1A(2), TUBA1B(1), TUBA1C(1), TUBA3C(8), TUBA3D(7), TUBA3E(8), TUBA4A(1), TUBA8(5), TUBAL3(5), TUBB1(5), TUBB2A(3), TUBB2B(3), TUBB3(7), TUBB6(7), TUBB8(2)	56543534	831	178	807	292	275	197	33	183	138	5	0.282	1.000	1.000
204	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	72	ARAF(11), BRAF(16), CACNA1A(24), CRHR1(11), GNA11(6), GNA12(1), GNA13(5), GNAI1(1), GNAI2(3), GNAI3(7), GNAO1(1), GNAQ(4), GNAS(29), GNAZ(17), GRIA1(20), GRIA2(23), GRIA3(8), GRID2(16), GRM1(31), GRM5(26), GUCY1A2(10), GUCY1A3(15), GUCY1B3(8), GUCY2C(12), GUCY2D(12), GUCY2F(15), IGF1(4), IGF1R(16), ITPR1(24), ITPR2(30), ITPR3(36), LYN(5), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK3(1), NOS1(28), NOS3(10), NPR1(11), NPR2(8), NRAS(3), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G2A(2), PLA2G2D(1), PLA2G2E(4), PLA2G3(9), PLA2G4A(6), PLA2G5(1), PLA2G6(6), PLCB1(19), PLCB2(8), PLCB3(12), PLCB4(13), PPP2CA(4), PPP2CB(3), PPP2R1A(11), PPP2R1B(6), PPP2R2A(6), PPP2R2B(8), PPP2R2C(8), PRKCA(5), PRKCG(17), PRKG1(10), PRKG2(13), RAF1(10), RYR1(61)	46960385	767	175	736	232	273	169	28	177	115	5	0.0115	1.000	1.000
205	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	149	AKT1(3), AKT2(8), AKT3(6), CBL(3), CBLB(3), CBLC(5), CCND1(1), CCND2(3), CCND3(2), CISH(3), CLCF1(2), CNTF(3), CNTFR(3), CREBBP(40), CRLF2(2), CSF2RA(9), CSF2RB(9), CSF3(2), CSF3R(13), EP300(22), EPO(1), EPOR(3), GH1(2), GH2(1), GHR(6), GRB2(4), IFNA1(1), IFNA10(4), IFNA13(1), IFNA16(4), IFNA2(1), IFNA4(1), IFNA5(2), IFNA6(3), IFNA7(4), IFNA8(1), IFNAR1(8), IFNAR2(6), IFNB1(3), IFNG(2), IFNGR1(6), IFNGR2(2), IFNK(1), IFNW1(4), IL10(2), IL10RA(5), IL10RB(3), IL11(3), IL11RA(3), IL12A(2), IL12B(2), IL12RB1(5), IL12RB2(11), IL13(2), IL13RA1(4), IL13RA2(6), IL15RA(3), IL19(1), IL20(1), IL20RA(8), IL21(4), IL21R(9), IL22(1), IL22RA1(2), IL22RA2(1), IL23A(3), IL23R(7), IL26(4), IL2RA(3), IL2RB(2), IL2RG(6), IL3(1), IL3RA(5), IL4(1), IL4R(3), IL5RA(4), IL6R(2), IL6ST(6), IL7(1), IL7R(9), IL9R(2), IRF9(7), JAK1(12), JAK2(13), JAK3(13), LEP(2), LEPR(13), LIF(2), LIFR(13), MPL(5), MYC(5), OSM(5), OSMR(8), PIAS1(12), PIAS2(11), PIAS3(7), PIAS4(7), PIK3CB(13), PIK3CD(11), PIK3CG(21), PIK3R1(11), PIK3R2(11), PIK3R3(8), PIK3R5(8), PIM1(2), PRL(1), PRLR(4), PTPN11(6), PTPN6(4), SOCS1(1), SOCS2(2), SOCS3(3), SOCS4(6), SOCS5(6), SOCS7(3), SOS1(7), SOS2(19), SPRED1(13), SPRED2(7), SPRY1(3), SPRY3(6), SPRY4(5), STAM(7), STAM2(5), STAT1(10), STAT2(10), STAT3(7), STAT4(6), STAT5A(3), STAT5B(14), STAT6(3), TPO(24), TSLP(1), TYK2(9)	61234552	765	173	722	231	194	192	26	155	192	6	0.0849	1.000	1.000
206	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	71	ACP1(5), ACTB(8), ACTG1(1), ACTN1(7), ACTN2(23), ACTN4(11), ACVR1B(13), ACVR1C(5), BAIAP2(5), CDC42(1), CREBBP(40), CSNK2A1(5), CSNK2A2(6), CSNK2B(1), CTNNA1(15), CTNNA2(19), CTNNA3(16), CTNNB1(22), CTNND1(19), EGFR(15), EP300(22), ERBB2(15), FARP2(4), FER(13), FGFR1(13), FYN(10), IGF1R(16), INSR(14), IQGAP1(14), LEF1(8), LMO7(14), MAP3K7(10), MAPK1(3), MAPK3(1), MET(8), MLLT4(24), PARD3(11), PTPN1(3), PTPN6(4), PTPRB(21), PTPRF(18), PTPRJ(27), PTPRM(28), PVRL1(1), PVRL2(5), PVRL3(6), PVRL4(7), RAC2(2), RAC3(4), SMAD2(9), SMAD3(5), SNAI1(3), SNAI2(11), SORBS1(9), SRC(3), SSX2IP(9), TCF7(8), TCF7L1(5), TCF7L2(11), TGFBR1(4), TGFBR2(14), TJP1(21), VCL(6), WAS(3), WASF1(5), WASF2(5), WASF3(13), WASL(3), YES1(2)	49675833	712	169	679	217	199	190	22	124	168	9	0.0304	1.000	1.000
207	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	87	ADCY1(19), ADCY2(17), ADCY3(12), ADCY4(9), ADCY5(13), ADCY6(14), ADCY7(16), ADCY8(31), ADCY9(13), AKAP1(3), AKAP10(3), AKAP11(16), AKAP12(18), AKAP2(10), AKAP3(12), AKAP4(11), AKAP5(1), AKAP6(23), AKAP7(3), AKAP8(10), AKAP9(38), ARHGEF1(11), CALM1(2), CALM2(2), CHMP1B(1), GNA11(6), GNA12(1), GNA13(5), GNA14(4), GNA15(3), GNAI2(3), GNAI3(7), GNAL(2), GNAO1(1), GNAQ(4), GNAZ(17), GNB1(1), GNB2(3), GNB3(1), GNB5(1), GNG10(1), GNG13(2), GNGT1(3), GNGT2(2), ITPR1(24), NRAS(3), PALM2(6), PDE1A(7), PDE1B(6), PDE1C(11), PDE4A(7), PDE4B(5), PDE4C(6), PDE4D(4), PDE7A(5), PDE7B(3), PDE8A(10), PDE8B(5), PLCB3(12), PPP3CA(10), PPP3CC(5), PRKACA(4), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), PRKCA(5), PRKCD(7), PRKCE(14), PRKCG(17), PRKCH(6), PRKCI(8), PRKCQ(10), PRKD1(20), PRKD3(5), RRAS(1), SLC9A1(10), USP5(6)	49267882	648	168	621	233	187	165	22	137	130	7	0.465	1.000	1.000
208	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	126	ACACA(22), ACACB(35), AKT1(3), AKT2(8), AKT3(6), ARAF(11), BAD(3), BRAF(16), CALM1(2), CALM2(2), CALML3(1), CBL(3), CBLB(3), CBLC(5), CRKL(1), EIF4EBP1(2), ELK1(3), EXOC7(11), FASN(19), FBP1(4), FBP2(5), FLOT1(2), FLOT2(5), FOXO1(4), G6PC2(1), GCK(4), GRB2(4), GSK3B(5), GYS1(6), GYS2(6), IKBKB(8), INPP5D(4), INSR(14), IRS1(24), IRS2(6), IRS4(27), LIPE(6), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK10(5), MAPK3(1), MAPK8(5), MAPK9(3), MKNK1(3), MKNK2(7), NRAS(3), PCK1(11), PCK2(9), PDE3A(14), PDE3B(20), PDPK1(2), PFKL(5), PFKM(2), PFKP(14), PHKA1(10), PHKA2(10), PHKB(6), PHKG1(2), PIK3CB(13), PIK3CD(11), PIK3CG(21), PIK3R1(11), PIK3R2(11), PIK3R3(8), PIK3R5(8), PKLR(7), PPARGC1A(10), PPP1CA(2), PPP1CB(1), PPP1CC(5), PPP1R3B(7), PPP1R3C(4), PPP1R3D(3), PRKAA1(6), PRKAA2(7), PRKAB1(6), PRKAB2(4), PRKACA(4), PRKACB(4), PRKACG(8), PRKAG1(4), PRKAG2(5), PRKAG3(3), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), PRKCI(8), PRKX(5), PTPN1(3), PTPRF(18), PYGB(10), PYGL(8), PYGM(14), RAF1(10), RAPGEF1(9), RHEB(1), RPS6(1), RPS6KB1(5), RPS6KB2(4), SH2B2(4), SHC1(7), SHC2(2), SHC3(10), SHC4(4), SLC2A4(4), SOCS1(1), SOCS2(2), SOCS3(3), SOCS4(6), SORBS1(9), SOS1(7), SOS2(19), SREBF1(12), TRIP10(9), TSC1(7), TSC2(12)	66047110	840	167	797	297	273	184	24	141	208	10	0.558	1.000	1.000
209	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	109	ADA(5), ADCY1(19), ADCY2(17), ADCY3(12), ADCY4(9), ADCY5(13), ADCY6(14), ADCY7(16), ADCY8(31), ADK(4), ADSL(5), ADSS(5), AK1(1), AK5(4), ALLC(5), AMPD1(9), AMPD2(13), AMPD3(20), APRT(3), ATIC(6), ATP1B1(6), ATP5A1(2), ATP5B(7), ATP5C1(3), ATP5F1(1), ATP5G2(1), ATP5G3(1), ATP5J(1), ATP5J2(1), CANT1(4), DGUOK(2), ENPP1(7), ENPP3(8), ENTPD1(5), ENTPD2(4), GART(9), GDA(4), GMPS(7), GUCY1A2(10), GUCY1A3(15), GUCY1B3(8), GUCY2C(12), GUCY2D(12), GUCY2F(15), GUK1(4), IMPDH1(5), ITPA(1), NME2(3), NPR1(11), NPR2(8), NT5C(1), NT5E(2), NUDT2(4), PAICS(1), PAPSS1(6), PAPSS2(5), PDE1A(7), PDE4A(7), PDE4B(5), PDE4C(6), PDE4D(4), PDE5A(7), PDE6B(10), PDE6C(4), PDE6G(1), PDE7B(3), PDE8A(10), PDE9A(7), PFAS(9), PKLR(7), POLB(4), POLD1(15), POLD2(4), POLE(24), POLG(8), POLL(3), POLQ(29), POLR1B(8), POLR2A(19), POLR2B(11), POLR2C(4), POLR2E(2), POLR2F(4), POLR2G(1), POLR2I(2), POLR2K(1), POLRMT(9), PPAT(5), PRPS1(3), PRPS1L1(2), PRPS2(3), PRUNE(4), RRM1(5), RRM2(4)	54802177	668	166	650	222	195	172	25	149	122	5	0.240	1.000	1.000
210	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	108	ACTN1(7), ACTN2(23), ACTN4(11), ARHGAP5(18), BCAR1(8), CD99(1), CDC42(1), CDH5(10), CLDN1(3), CLDN10(2), CLDN11(1), CLDN14(3), CLDN15(1), CLDN16(4), CLDN17(6), CLDN18(2), CLDN19(6), CLDN2(1), CLDN20(4), CLDN22(3), CLDN23(3), CLDN3(1), CLDN4(6), CLDN5(2), CLDN6(7), CLDN8(2), CLDN9(7), CTNNA1(15), CTNNA2(19), CTNNA3(16), CTNNB1(22), CTNND1(19), CXCR4(1), CYBB(8), ESAM(5), EZR(6), F11R(2), GNAI1(1), GNAI2(3), GNAI3(7), ICAM1(2), ITGA4(12), ITGAL(16), ITGAM(9), ITGB1(10), ITGB2(6), ITK(6), JAM2(2), JAM3(7), MAPK11(1), MAPK13(3), MAPK14(1), MLLT4(24), MMP2(6), MMP9(17), MSN(9), MYL2(8), MYL7(1), MYL9(2), NCF1(3), NCF2(4), NCF4(1), NOX1(6), NOX3(5), OCLN(6), PIK3CB(13), PIK3CD(11), PIK3CG(21), PIK3R1(11), PIK3R2(11), PIK3R3(8), PIK3R5(8), PLCG1(19), PLCG2(15), PRKCA(5), PRKCG(17), PTK2(11), PTK2B(16), PTPN11(6), PXN(4), RAC2(2), RAP1A(2), RAP1B(6), RAPGEF3(2), RAPGEF4(8), RASSF5(4), RHOH(1), ROCK1(18), ROCK2(12), SIPA1(4), THY1(1), TXK(2), VASP(2), VAV1(9), VAV2(12), VAV3(10), VCAM1(10), VCL(6)	52183069	721	162	681	253	219	161	29	126	174	12	0.572	1.000	1.000
211	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	66	ADCY1(19), ADCY8(31), ARAF(11), ATF4(2), BRAF(16), CACNA1C(37), CALM1(2), CALM2(2), CALML3(1), CAMK2A(3), CAMK2B(4), CAMK2D(3), CAMK2G(8), CAMK4(8), CREBBP(40), EP300(22), GNAQ(4), GRIA1(20), GRIA2(23), GRIN1(8), GRIN2A(16), GRIN2B(23), GRIN2C(6), GRIN2D(7), GRM1(31), GRM5(26), ITPR1(24), ITPR2(30), ITPR3(36), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK3(1), NRAS(3), PLCB1(19), PLCB2(8), PLCB3(12), PLCB4(13), PPP1CA(2), PPP1CB(1), PPP1CC(5), PPP1R12A(2), PPP1R1A(1), PPP3CA(10), PPP3CB(6), PPP3CC(5), PPP3R1(2), PRKACA(4), PRKACB(4), PRKACG(8), PRKCA(5), PRKCG(17), PRKX(5), RAF1(10), RAP1A(2), RAP1B(6), RAPGEF3(2), RPS6KA1(9), RPS6KA2(9), RPS6KA3(4), RPS6KA6(15)	42454473	664	162	640	211	213	165	18	132	132	4	0.0230	1.000	1.000
212	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	92	ADCY1(19), ADCY2(17), ADCY3(12), ADCY4(9), ADCY5(13), ADCY6(14), ADCY7(16), ADCY8(31), ADCY9(13), ATF4(2), CACNA1C(37), CACNA1D(35), CACNA1F(11), CACNA1S(17), CALM1(2), CALM2(2), CALML3(1), CAMK2A(3), CAMK2B(4), CAMK2D(3), CAMK2G(8), CDC42(1), CGA(1), EGFR(15), ELK1(3), FSHB(1), GNA11(6), GNAQ(4), GNAS(29), GNRH1(1), GNRH2(2), GNRHR(4), GRB2(4), HBEGF(1), ITPR1(24), ITPR2(30), ITPR3(36), JUN(4), LHB(1), MAP2K1(5), MAP2K2(3), MAP2K3(4), MAP2K4(8), MAP2K6(1), MAP3K1(11), MAP3K2(4), MAP3K3(8), MAP3K4(21), MAPK1(3), MAPK10(5), MAPK11(1), MAPK13(3), MAPK14(1), MAPK3(1), MAPK7(6), MAPK8(5), MAPK9(3), MMP14(6), MMP2(6), NRAS(3), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G2A(2), PLA2G2D(1), PLA2G2E(4), PLA2G3(9), PLA2G4A(6), PLA2G5(1), PLA2G6(6), PLCB1(19), PLCB2(8), PLCB3(12), PLCB4(13), PLD1(19), PLD2(16), PRKACA(4), PRKACB(4), PRKACG(8), PRKCA(5), PRKCD(7), PRKX(5), PTK2B(16), RAF1(10), SOS1(7), SOS2(19), SRC(3)	53966587	753	162	733	245	267	175	27	137	140	7	0.0424	1.000	1.000
213	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	104	ABL1(7), ANAPC1(13), ANAPC10(2), ANAPC11(1), ANAPC2(7), ANAPC5(4), ANAPC7(6), ATM(38), ATR(18), BUB1(12), BUB1B(10), BUB3(4), CCNA1(6), CCNA2(1), CCNB1(3), CCNB2(1), CCNB3(20), CCND1(1), CCND2(3), CCND3(2), CCNE1(5), CCNE2(3), CCNH(2), CDC14B(4), CDC16(7), CDC20(5), CDC23(6), CDC25A(6), CDC25B(4), CDC26(1), CDC27(3), CDC6(8), CDC7(4), CDK2(3), CDK6(4), CDKN1A(3), CDKN2D(3), CHEK1(4), CHEK2(8), CREBBP(40), CUL1(22), DBF4(7), E2F1(3), E2F2(4), E2F3(3), EP300(22), ESPL1(15), FZR1(7), GADD45B(1), GSK3B(5), HDAC1(5), HDAC2(2), MAD1L1(8), MAD2L1(3), MAD2L2(1), MCM2(14), MCM3(6), MCM4(13), MCM5(8), MCM6(8), MCM7(7), MDM2(5), PCNA(2), PKMYT1(3), PLK1(9), PRKDC(40), PTTG1(1), RB1(13), RBL1(11), RBL2(8), RBX1(1), SFN(1), SKP2(5), SMAD2(9), SMAD3(5), SMC1A(7), SMC1B(6), TFDP1(5), TGFB1(3), TGFB2(6), TGFB3(8), WEE1(4), YWHAB(2), YWHAE(2), YWHAG(1), YWHAH(3), YWHAQ(2), YWHAZ(3)	56189777	611	161	588	186	164	157	15	126	145	4	0.183	1.000	1.000
214	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	81	ABL1(7), ABL2(12), AKT1(3), AKT2(8), AKT3(6), ARAF(11), BAD(3), BRAF(16), BTC(2), CAMK2A(3), CAMK2B(4), CAMK2D(3), CAMK2G(8), CBL(3), CBLB(3), CBLC(5), CDKN1A(3), CRKL(1), EGF(10), EGFR(15), EIF4EBP1(2), ELK1(3), ERBB2(15), ERBB4(48), EREG(2), GAB1(3), GRB2(4), GSK3B(5), HBEGF(1), JUN(4), MAP2K1(5), MAP2K2(3), MAP2K4(8), MAPK1(3), MAPK10(5), MAPK3(1), MAPK8(5), MAPK9(3), MYC(5), NCK1(6), NCK2(5), NRAS(3), NRG1(14), NRG2(8), NRG3(17), NRG4(2), PAK1(5), PAK2(7), PAK3(5), PAK4(8), PAK6(9), PAK7(9), PIK3CB(13), PIK3CD(11), PIK3CG(21), PIK3R1(11), PIK3R2(11), PIK3R3(8), PIK3R5(8), PLCG1(19), PLCG2(15), PRKCA(5), PRKCG(17), PTK2(11), RAF1(10), RPS6KB1(5), RPS6KB2(4), SHC1(7), SHC2(2), SHC3(10), SHC4(4), SOS1(7), SOS2(19), SRC(3), STAT5A(3), STAT5B(14), TGFA(2)	41543809	589	160	551	188	178	136	27	108	135	5	0.189	1.000	1.000
215	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	81	ACVR1(5), ACVR1B(13), ACVRL1(5), AKT1(3), AURKB(5), BMPR1A(5), BMPR2(16), BUB1(12), CDIPT(1), CDKL2(3), CDS1(6), CDS2(2), CLK1(4), CLK2(11), CLK4(4), COL4A3BP(3), CSNK2A1(5), CSNK2A2(6), CSNK2B(1), DGKA(7), DGKB(11), DGKD(6), DGKE(7), DGKG(4), DGKH(10), DGKQ(2), DGKZ(8), IMPA1(4), INPP1(1), INPP4A(6), INPP4B(7), INPP5A(8), INPPL1(24), ITPKA(2), ITPKB(11), MAP3K10(8), MOS(11), NEK1(4), NEK3(3), OCRL(9), PAK4(8), PIK3C2A(14), PIK3C2B(19), PIK3C2G(10), PIK3CB(13), PIK3CG(21), PIM2(3), PLCB1(19), PLCB2(8), PLCB3(12), PLCB4(13), PLCD1(4), PLCG1(19), PLCG2(15), PLK3(6), PRKACA(4), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), PRKCA(5), PRKCD(7), PRKCE(14), PRKCG(17), PRKCH(6), PRKCQ(10), PRKD1(20), PRKG1(10), RAF1(10), RPS6KA1(9), RPS6KA2(9), RPS6KA3(4), RPS6KA4(6), RPS6KB1(5), STK11(3), TGFBR1(4), VRK1(1)	47406894	622	159	589	179	177	144	23	120	150	8	0.0564	1.000	1.000
216	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(3), AKT3(6), BCAR1(8), CAPN1(5), CAPN10(7), CAPN11(6), CAPN2(8), CAPN3(9), CAPN5(9), CAPN6(7), CAPN7(8), CAPN9(4), CAPNS1(2), CAV1(4), CAV2(2), CAV3(2), CDC42(1), CSK(7), DOCK1(17), FYN(10), GIT2(2), GRB2(4), ILK(8), ITGA10(9), ITGA11(10), ITGA2(8), ITGA2B(9), ITGA3(11), ITGA4(12), ITGA5(5), ITGA6(6), ITGA7(16), ITGA8(6), ITGA9(8), ITGAD(12), ITGAE(12), ITGAL(16), ITGAM(9), ITGAV(13), ITGAX(14), ITGB1(10), ITGB2(6), ITGB3(7), ITGB4(18), ITGB5(7), ITGB6(4), ITGB7(6), ITGB8(14), MAP2K1(5), MAP2K2(3), MAP2K3(4), MAP2K6(1), MAPK10(5), MAPK4(6), MAPK6(1), MAPK7(6), MYLK2(4), PAK1(5), PAK2(7), PAK3(5), PAK4(8), PAK6(9), PDPK1(2), PIK3R2(11), PTK2(11), PXN(4), RAC2(2), RAC3(4), RAP1B(6), RAPGEF1(9), RHO(7), ROCK1(18), ROCK2(12), SDCCAG8(5), SEPP1(1), SHC1(7), SHC3(10), SORBS1(9), SOS1(7), SRC(3), TLN1(23), TNS1(27), VASP(2), VAV2(12), VAV3(10), VCL(6), ZYX(7)	57422581	671	158	648	234	213	153	29	121	143	12	0.382	1.000	1.000
217	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	96	ADCY1(19), ADCY2(17), ADCY3(12), ADCY4(9), ADCY5(13), ADCY6(14), ADCY7(16), ADCY8(31), ADCY9(13), ASIP(2), CALM1(2), CALM2(2), CALML3(1), CAMK2A(3), CAMK2B(4), CAMK2D(3), CAMK2G(8), CREB1(3), CREB3L1(4), CREB3L2(4), CREB3L3(4), CREB3L4(2), CREBBP(40), CTNNB1(22), DCT(13), DVL1(7), DVL2(6), DVL3(12), EDN1(3), EP300(22), FZD1(10), FZD10(18), FZD2(7), FZD3(11), FZD4(6), FZD5(4), FZD6(9), FZD7(7), FZD8(10), FZD9(2), GNAI1(1), GNAI2(3), GNAI3(7), GNAO1(1), GNAQ(4), GNAS(29), GSK3B(5), KIT(12), KITLG(3), LEF1(8), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK3(1), MC1R(6), MITF(10), NRAS(3), PLCB1(19), PLCB2(8), PLCB3(12), PLCB4(13), POMC(8), PRKACA(4), PRKACB(4), PRKACG(8), PRKCA(5), PRKCG(17), PRKX(5), RAF1(10), TCF7(8), TCF7L1(5), TCF7L2(11), TYR(9), TYRP1(4), WNT1(8), WNT10A(5), WNT10B(2), WNT11(2), WNT2(4), WNT2B(10), WNT3(5), WNT3A(6), WNT4(2), WNT5A(6), WNT5B(4), WNT6(3), WNT7A(5), WNT7B(7), WNT8A(1), WNT8B(1), WNT9A(8), WNT9B(4)	45852713	732	157	700	253	270	176	21	127	135	3	0.0524	1.000	1.000
218	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	71	CALM1(2), CALM2(2), CALML3(1), CDIPT(1), CDS1(6), CDS2(2), DGKA(7), DGKB(11), DGKD(6), DGKE(7), DGKG(4), DGKH(10), DGKI(16), DGKQ(2), DGKZ(8), FN3K(3), IMPA1(4), IMPA2(2), INPP1(1), INPP4A(6), INPP4B(7), INPP5A(8), INPP5B(7), INPP5D(4), INPP5E(6), INPPL1(24), ITPK1(4), ITPKA(2), ITPKB(11), ITPR1(24), ITPR2(30), ITPR3(36), OCRL(9), PI4KA(14), PI4KB(5), PIK3C2A(14), PIK3C2B(19), PIK3C2G(10), PIK3C3(14), PIK3CB(13), PIK3CD(11), PIK3CG(21), PIK3R1(11), PIK3R2(11), PIK3R3(8), PIK3R5(8), PIP4K2A(6), PIP4K2B(4), PIP4K2C(2), PIP5K1A(4), PIP5K1B(1), PIP5K1C(11), PLCB1(19), PLCB2(8), PLCB3(12), PLCB4(13), PLCD1(4), PLCD3(9), PLCD4(5), PLCE1(14), PLCG1(19), PLCG2(15), PLCZ1(6), PRKCA(5), PRKCG(17), PTPMT1(1), SYNJ1(10), SYNJ2(18)	52075445	635	156	599	193	208	145	20	113	141	8	0.0458	1.000	1.000
219	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	67	A2M(20), BDKRB1(2), BDKRB2(4), C1QA(5), C1QB(1), C1QC(2), C1R(5), C1S(7), C2(1), C3(30), C3AR1(8), C4BPA(3), C4BPB(3), C5(11), C5AR1(5), C6(12), C7(3), C8A(5), C8B(14), C9(7), CD46(3), CD55(3), CFB(6), CFH(20), CFI(13), CPB2(10), CR1(27), CR2(22), F10(7), F11(4), F12(3), F13A1(14), F13B(16), F2(9), F2R(3), F3(1), F5(21), F7(10), F8(22), F9(9), FGA(9), FGB(4), FGG(3), KLKB1(7), KNG1(9), MASP1(1), MASP2(6), MBL2(4), PLAT(7), PLAUR(4), PLG(14), PROC(3), PROS1(9), SERPINA1(7), SERPINA5(7), SERPINC1(4), SERPIND1(5), SERPINE1(3), SERPINF2(8), SERPING1(7), TFPI(4), THBD(1), VWF(28)	38840565	525	153	495	147	131	127	23	120	122	2	0.0282	1.000	1.000
220	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	86	ACVR1(5), ACVR1B(13), ACVR1C(5), ACVR2A(8), ACVR2B(5), ACVRL1(5), AMHR2(4), BMP2(5), BMP4(6), BMP5(11), BMP6(10), BMP7(7), BMP8A(1), BMP8B(2), BMPR1A(5), BMPR1B(7), BMPR2(16), CHRD(9), COMP(3), CREBBP(40), CUL1(22), DCN(8), E2F5(1), EP300(22), FST(4), GDF5(11), GDF6(15), GDF7(4), ID1(1), ID3(1), IFNG(2), INHBA(12), INHBB(10), INHBC(6), INHBE(2), LEFTY1(2), LTBP1(20), MAPK1(3), MAPK3(1), MYC(5), NOG(1), PITX2(6), PPP2CA(4), PPP2CB(3), PPP2R1A(11), PPP2R1B(6), PPP2R2A(6), PPP2R2B(8), PPP2R2C(8), RBL1(11), RBL2(8), RBX1(1), ROCK1(18), ROCK2(12), RPS6KB1(5), RPS6KB2(4), SMAD1(4), SMAD2(9), SMAD3(5), SMAD5(2), SMAD6(5), SMAD7(5), SMAD9(9), SMURF1(6), SMURF2(5), SP1(6), TFDP1(5), TGFB1(3), TGFB2(6), TGFB3(8), TGFBR1(4), TGFBR2(14), THBS1(16), THBS2(15), THBS3(9), THBS4(13), TNF(3), ZFYVE16(11), ZFYVE9(8)	41763099	602	152	581	199	187	140	27	98	141	9	0.168	1.000	1.000
221	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	74	ABL1(7), ACTN1(7), ACTR2(2), ACTR3(2), AKT1(3), AKT2(8), AKT3(6), ANGPTL2(4), ARHGEF6(13), ARHGEF7(8), BCAR1(8), BRAF(16), CAV1(4), CDC42(1), CSE1L(5), DOCK1(17), EPHB2(12), FYN(10), GRB2(4), GRB7(6), ILK(8), ITGA1(8), ITGA10(9), ITGA11(10), ITGA2(8), ITGA3(11), ITGA4(12), ITGA5(5), ITGA6(6), ITGA7(16), ITGA8(6), ITGA9(8), ITGB3BP(1), MAP2K4(8), MAP3K11(7), MAPK1(3), MAPK10(5), MAPK8(5), MAPK8IP1(4), MAPK8IP2(4), MAPK8IP3(13), MAPK9(3), MRAS(2), MYLK(22), MYLK2(4), P4HB(4), PAK1(5), PAK2(7), PAK3(5), PAK4(8), PAK6(9), PAK7(9), PIK3CB(13), PKLR(7), PLCG1(19), PLCG2(15), PTK2(11), RAF1(10), RHO(7), ROCK1(18), ROCK2(12), SHC1(7), SOS1(7), SOS2(19), SRC(3), TERF2IP(5), TLN1(23), TLN2(27), VASP(2), WAS(3), ZYX(7)	50636122	593	152	576	197	195	131	20	102	133	12	0.334	1.000	1.000
222	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	88	AKT1(3), AKT2(8), AKT3(6), BCL10(2), CARD11(20), CBL(3), CBLB(3), CBLC(5), CD247(3), CD28(1), CD3E(2), CD3G(1), CD40LG(5), CD8A(4), CD8B(1), CDC42(1), CHUK(4), CTLA4(3), FOS(1), FYN(10), GRAP2(4), GRB2(4), ICOS(2), IFNG(2), IKBKB(8), IL10(2), IL4(1), ITK(6), JUN(4), LAT(3), LCK(4), LCP2(7), MALT1(4), NCK1(6), NCK2(5), NFAT5(10), NFATC1(13), NFATC2(17), NFATC3(4), NFATC4(16), NFKB1(7), NFKB2(7), NFKBIA(1), NFKBIB(6), NRAS(3), PAK1(5), PAK2(7), PAK3(5), PAK4(8), PAK6(9), PAK7(9), PDCD1(2), PDK1(3), PIK3CB(13), PIK3CD(11), PIK3CG(21), PIK3R1(11), PIK3R2(11), PIK3R3(8), PIK3R5(8), PLCG1(19), PPP3CA(10), PPP3CB(6), PPP3CC(5), PPP3R1(2), PRKCQ(10), PTPN6(4), PTPRC(19), RASGRP1(8), SOS1(7), SOS2(19), TEC(4), TNF(3), VAV1(9), VAV2(12), VAV3(10), ZAP70(14)	41851337	524	149	504	169	164	127	17	99	114	3	0.165	1.000	1.000
223	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	43	ABCA1(18), ABCA10(19), ABCA12(31), ABCA13(52), ABCA2(18), ABCA3(17), ABCA4(17), ABCA5(21), ABCA6(16), ABCA7(13), ABCA8(14), ABCA9(16), ABCB1(26), ABCB10(12), ABCB11(9), ABCB4(23), ABCB5(16), ABCB6(9), ABCB7(4), ABCB8(8), ABCB9(4), ABCC1(16), ABCC10(10), ABCC11(16), ABCC12(17), ABCC2(12), ABCC3(11), ABCC4(18), ABCC5(11), ABCC6(15), ABCC8(17), ABCD1(6), ABCD2(4), ABCD3(5), ABCD4(8), ABCG1(10), ABCG2(6), ABCG4(4), ABCG5(2), ABCG8(5), CFTR(14), TAP1(4), TAP2(6)	49136307	580	146	554	185	161	152	18	113	127	9	0.0567	1.000	1.000
224	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	76	ABL1(7), ATM(38), BUB1(12), BUB1B(10), BUB3(4), CCNA1(6), CCNA2(1), CCNB1(3), CCNB2(1), CCNB3(20), CCND2(3), CCND3(2), CCNE1(5), CCNE2(3), CCNH(2), CDAN1(12), CDC14B(4), CDC20(5), CDC25A(6), CDC25B(4), CDC6(8), CDC7(4), CDK2(3), CDKN1A(3), CHEK1(4), CHEK2(8), DTX4(7), E2F1(3), E2F2(4), E2F3(3), E2F5(1), E2F6(2), EP300(22), ESPL1(15), GSK3B(5), HDAC1(5), HDAC2(2), HDAC3(6), HDAC4(25), HDAC5(10), HDAC6(7), HDAC8(3), MAD1L1(8), MAD2L1(3), MAD2L2(1), MCM2(14), MCM3(6), MCM4(13), MCM5(8), MCM6(8), MCM7(7), MDM2(5), MPEG1(10), MPL(5), PCNA(2), PLK1(9), PRKDC(40), PTPRA(12), PTTG1(1), RB1(13), RBL1(11), SKP2(5), TBC1D8(9), TFDP1(5), TGFB1(3), WEE1(4)	44349286	500	145	479	154	138	126	17	103	112	4	0.200	1.000	1.000
225	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	59	AKT1(3), AKT2(8), AKT3(6), BAD(3), CDC42(1), CDK2(3), CREB1(3), CREB5(5), EBP(1), ERBB4(48), F2RL2(3), GAB1(3), GRB2(4), GSK3A(3), GSK3B(5), IFI27(1), IGF1(4), INPPL1(24), IRS1(24), IRS2(6), IRS4(27), MET(8), MYC(5), NOLC1(9), PAK1(5), PAK2(7), PAK3(5), PAK4(8), PAK6(9), PAK7(9), PARD3(11), PARD6A(1), PDK1(3), PIK3CD(11), PPP1R13B(11), PREX1(16), PTK2(11), PTPN1(3), RPS6KA1(9), RPS6KA2(9), RPS6KA3(4), RPS6KB1(5), SFN(1), SHC1(7), SLC2A4(4), SOS1(7), SOS2(19), TSC1(7), TSC2(12), YWHAB(2), YWHAE(2), YWHAG(1), YWHAH(3), YWHAQ(2), YWHAZ(3)	31497999	414	145	388	121	133	89	18	68	102	4	0.0718	1.000	1.000
226	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	94	AKT1(3), AKT2(8), AKT3(6), CCL3(1), CCL5(2), CD14(2), CD40(3), CD80(4), CD86(6), CHUK(4), CXCL10(1), CXCL9(2), FADD(1), FOS(1), IFNA1(1), IFNA10(4), IFNA13(1), IFNA16(4), IFNA2(1), IFNA4(1), IFNA5(2), IFNA6(3), IFNA7(4), IFNA8(1), IFNAR1(8), IFNAR2(6), IFNB1(3), IKBKB(8), IKBKE(12), IL12A(2), IL12B(2), IL1B(3), IRAK1(6), IRAK4(3), IRF3(3), IRF5(4), IRF7(1), JUN(4), LBP(1), LY96(4), MAP2K1(5), MAP2K2(3), MAP2K3(4), MAP2K4(8), MAP2K6(1), MAP3K7(10), MAPK1(3), MAPK10(5), MAPK11(1), MAPK13(3), MAPK14(1), MAPK3(1), MAPK8(5), MAPK9(3), MYD88(2), NFKB1(7), NFKB2(7), NFKBIA(1), PIK3CB(13), PIK3CD(11), PIK3CG(21), PIK3R1(11), PIK3R2(11), PIK3R3(8), PIK3R5(8), RELA(5), RIPK1(2), SPP1(4), STAT1(10), TBK1(8), TICAM1(8), TIRAP(1), TLR1(6), TLR2(2), TLR3(6), TLR4(21), TLR5(10), TLR6(3), TLR7(5), TLR8(14), TLR9(15), TNF(3), TOLLIP(5), TRAF3(4), TRAF6(6)	36580761	427	143	406	148	114	97	14	95	104	3	0.604	1.000	1.000
227	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	121	ARAF(11), BID(2), BRAF(16), CASP3(2), CD244(2), CD247(3), FAS(3), FASLG(3), FCGR3A(4), FYN(10), GRB2(4), GZMB(3), HCST(1), HLA-C(6), HLA-E(5), HLA-G(5), ICAM1(2), ICAM2(3), IFNA1(1), IFNA10(4), IFNA13(1), IFNA16(4), IFNA2(1), IFNA4(1), IFNA5(2), IFNA6(3), IFNA7(4), IFNA8(1), IFNAR1(8), IFNAR2(6), IFNB1(3), IFNG(2), IFNGR1(6), IFNGR2(2), ITGAL(16), ITGB2(6), KIR2DL3(3), KIR3DL1(5), KIR3DL2(2), KLRC1(3), KLRC3(2), KLRD1(3), LAT(3), LCK(4), LCP2(7), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK3(1), MICB(3), NCR1(3), NCR2(3), NCR3(1), NFAT5(10), NFATC1(13), NFATC2(17), NFATC3(4), NFATC4(16), NRAS(3), PAK1(5), PIK3CB(13), PIK3CD(11), PIK3CG(21), PIK3R1(11), PIK3R2(11), PIK3R3(8), PIK3R5(8), PLCG1(19), PLCG2(15), PPP3CA(10), PPP3CB(6), PPP3CC(5), PPP3R1(2), PRF1(8), PRKCA(5), PRKCG(17), PTK2B(16), PTPN11(6), PTPN6(4), RAC2(2), RAC3(4), RAF1(10), SH2D1A(1), SH2D1B(1), SH3BP2(5), SHC1(7), SHC2(2), SHC3(10), SHC4(4), SOS1(7), SOS2(19), SYK(7), TNF(3), TNFRSF10A(1), TNFRSF10B(2), TNFRSF10C(3), TNFRSF10D(3), TNFSF10(5), TYROBP(2), ULBP1(3), ULBP3(1), VAV1(9), VAV2(12), VAV3(10), ZAP70(14)	46789181	621	143	594	192	184	149	16	121	148	3	0.0349	1.000	1.000
228	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	106	A4GNT(1), ALG1(6), ALG10(11), ALG12(10), ALG13(8), ALG14(2), ALG2(2), ALG3(2), ALG6(2), ALG8(4), ALG9(2), B3GNT1(3), B3GNT2(3), B3GNT6(4), B3GNT7(5), B4GALT1(2), B4GALT2(7), B4GALT3(2), B4GALT4(5), B4GALT5(6), B4GALT7(5), C1GALT1(3), C1GALT1C1(7), CHPF(2), CHST1(14), CHST11(4), CHST12(5), CHST13(4), CHST14(1), CHST2(14), CHST3(3), CHST4(6), CHST6(11), CHST7(7), CHSY1(6), DPAGT1(4), EXT1(19), EXT2(5), EXTL1(8), EXTL2(2), EXTL3(10), FUT11(3), FUT8(7), GALNT1(4), GALNT10(7), GALNT11(6), GALNT12(3), GALNT13(8), GALNT14(10), GALNT2(5), GALNT3(4), GALNT4(5), GALNT5(12), GALNT6(6), GALNT7(2), GALNT8(6), GALNT9(3), GALNTL5(3), GANAB(12), GCNT3(3), GCNT4(4), HS2ST1(3), HS3ST1(3), HS3ST2(10), HS3ST3A1(2), HS3ST3B1(4), HS3ST5(8), HS6ST1(3), HS6ST2(7), HS6ST3(7), MAN1A1(2), MAN1A2(5), MAN1B1(6), MAN1C1(8), MAN2A1(5), MGAT1(3), MGAT2(2), MGAT3(8), MGAT4A(5), MGAT4B(3), MGAT5(10), MGAT5B(5), NDST1(11), NDST2(9), NDST3(13), NDST4(12), OGT(5), RPN1(3), RPN2(6), ST3GAL1(4), ST3GAL2(6), ST3GAL3(2), ST3GAL4(6), ST6GALNAC1(4), STT3B(5), UST(9), WBSCR17(25), XYLT1(12)	46223254	581	141	559	217	193	135	17	107	122	7	0.864	1.000	1.000
229	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	56	APC(43), AXIN1(9), CCND1(1), CCND2(3), CCND3(2), CSNK1E(8), CTNNB1(22), DVL1(7), DVL2(6), DVL3(12), FBXW2(3), FOSL1(1), FZD1(10), FZD10(18), FZD2(7), FZD3(11), FZD5(4), FZD6(9), FZD7(7), FZD8(10), FZD9(2), GSK3B(5), JUN(4), LDLR(10), MAPK10(5), MAPK9(3), MYC(5), PAFAH1B1(12), PPP2R5C(7), PPP2R5E(5), PRKCA(5), PRKCD(7), PRKCE(14), PRKCG(17), PRKCH(6), PRKCI(8), PRKCQ(10), PRKD1(20), SFRP4(5), TCF7(8), WNT1(8), WNT10A(5), WNT10B(2), WNT11(2), WNT2(4), WNT2B(10), WNT3(5), WNT4(2), WNT5A(6), WNT5B(4), WNT6(3), WNT7A(5), WNT7B(7)	25292624	414	141	391	139	128	79	14	79	103	11	0.256	1.000	1.000
230	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	51	ADORA3(5), ALG6(2), CCKBR(9), CCR2(6), CCR3(6), CCR5(4), CELSR1(39), CELSR2(31), CELSR3(47), CHRM2(17), CHRM3(11), CIDEB(2), CXCR3(1), DRD4(3), EDNRA(4), EMR2(9), EMR3(4), F2R(3), GHRHR(4), GNRHR(4), GPR116(13), GPR132(4), GPR133(13), GPR135(8), GPR143(4), GPR17(5), GPR18(3), GPR55(7), GPR56(6), GPR61(7), GPR84(2), GPR88(1), GRM1(31), GRPR(6), HRH4(3), LGR6(12), LPHN2(19), LPHN3(17), LTB4R2(4), NTSR1(7), OR2M4(5), P2RY13(4), PTGFR(5), SMO(13), SSTR2(4), TAAR5(6), TSHR(10), VN1R1(3)	27971269	433	139	421	139	141	108	22	95	64	3	0.0289	1.000	1.000
231	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	79	AGL(16), AMY2A(3), ASCC3(31), ATP13A2(13), DDX18(10), DDX19A(5), DDX23(8), DDX4(5), DDX41(8), DDX47(2), DDX50(11), DDX51(5), DDX52(3), DDX54(18), DDX55(5), DDX56(5), DHX58(9), ENPP1(7), ENPP3(8), ENTPD7(11), EP400(35), ERCC2(8), ERCC3(8), G6PC2(1), GAA(5), GANC(8), GBA(9), GBE1(5), GCK(4), GPI(5), GUSB(11), GYS1(6), GYS2(6), HK1(16), HK2(10), HK3(6), IFIH1(8), LYZL1(5), MGAM(15), MOV10L1(6), PGM1(2), PGM3(7), PYGB(10), PYGL(8), PYGM(14), RAD54B(3), RAD54L(5), RUVBL2(5), SETX(20), SI(27), SKIV2L2(8), SMARCA2(22), SMARCA5(7), TREH(1), UGDH(5), UGP2(7), UGT1A1(4), UGT1A10(1), UGT1A3(1), UGT1A4(3), UGT1A5(3), UGT1A6(6), UGT1A7(3), UGT1A9(3), UGT2A1(3), UGT2A3(6), UGT2B10(5), UGT2B11(1), UGT2B15(3), UGT2B17(2), UGT2B28(7), UGT2B4(4), UGT2B7(6), UXS1(5)	52505637	577	139	567	183	158	153	16	119	128	3	0.245	1.000	1.000
232	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	81	ANPEP(9), CD14(2), CD19(4), CD1B(7), CD1C(9), CD1D(8), CD1E(7), CD2(3), CD22(5), CD33(6), CD34(4), CD36(2), CD37(3), CD38(4), CD3E(2), CD3G(1), CD44(5), CD5(4), CD55(3), CD7(5), CD8A(4), CD8B(1), CD9(1), CR1(27), CR2(22), CSF1(2), CSF1R(15), CSF2RA(9), CSF3(2), CSF3R(13), DNTT(3), EPO(1), EPOR(3), FCER2(2), FLT3(10), FLT3LG(1), GP5(7), GP9(3), HLA-DRA(8), IL11(3), IL11RA(3), IL1A(2), IL1B(3), IL1R1(4), IL1R2(10), IL2RA(3), IL3(1), IL3RA(5), IL4(1), IL4R(3), IL5RA(4), IL6R(2), IL7(1), IL7R(9), IL9R(2), ITGA1(8), ITGA2(8), ITGA2B(9), ITGA3(11), ITGA4(12), ITGA5(5), ITGA6(6), ITGAM(9), ITGB3(7), KIT(12), KITLG(3), MME(8), MS4A1(1), TFRC(2), THPO(6), TNF(3), TPO(24)	34310749	417	139	391	136	109	94	17	92	101	4	0.285	1.000	1.000
233	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP2(5), BMP4(6), BMP5(11), BMP6(10), BMP7(7), BMP8A(1), BMP8B(2), BTRC(9), CSNK1A1(3), CSNK1A1L(6), CSNK1D(2), CSNK1E(8), CSNK1G1(6), CSNK1G2(5), CSNK1G3(8), DHH(2), FBXW11(10), GAS1(4), GLI1(20), GLI2(14), GLI3(47), GSK3B(5), HHIP(16), IHH(7), LRP2(59), PRKACA(4), PRKACB(4), PRKACG(8), PRKX(5), PTCH1(23), PTCH2(10), RAB23(2), SHH(4), SMO(13), STK36(11), SUFU(5), WNT1(8), WNT10A(5), WNT10B(2), WNT11(2), WNT2(4), WNT2B(10), WNT3(5), WNT3A(6), WNT4(2), WNT5A(6), WNT5B(4), WNT6(3), WNT7A(5), WNT7B(7), WNT8A(1), WNT8B(1), WNT9A(8), WNT9B(4), ZIC2(5)	25751704	450	138	424	137	157	94	16	85	91	7	0.0572	1.000	1.000
234	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	91	ACTB(8), BAD(3), BCL2(3), CABIN1(15), CALM1(2), CALM2(2), CAMK2B(4), CAMK4(8), CD3E(2), CD3G(1), CD69(3), CDKN1A(3), CNR1(11), CREBBP(40), CSNK2A1(5), CSNK2B(1), CTLA4(3), EGR2(8), EGR3(6), EP300(22), FCER1A(3), FCGR3A(4), FOS(1), FOSL1(1), GATA3(17), GATA4(4), GSK3A(3), GSK3B(5), ICOS(2), IFNA1(1), IFNB1(3), IFNG(2), IL10(2), IL13(2), IL1B(3), IL2RA(3), IL3(1), IL4(1), ITK(6), JUNB(3), KPNA5(6), MAPK14(1), MAPK8(5), MAPK9(3), MEF2A(2), MEF2B(5), MEF2D(7), MYF5(5), NCK2(5), NFAT5(10), NFATC1(13), NFATC2(17), NFATC3(4), NFATC4(16), NFKB2(7), NFKBIB(6), NPPB(2), NUP214(23), OPRD1(2), P2RX7(1), PAK1(5), PIN1(2), PPP3CB(6), PPP3CC(5), PPP3R1(2), PTPRC(19), RELA(5), RPL13A(4), SFN(1), SLA(4), SP1(6), SP3(3), TGFB1(3), TNF(3), TRAF2(4), TRPV6(9), VAV1(9), VAV2(12), VAV3(10), XPO5(4)	38827559	473	135	455	167	136	126	17	95	95	4	0.387	1.000	1.000
235	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(3), AKT1(3), BDKRB2(4), CALM1(2), CALM2(2), CAV1(4), CHRM1(4), CHRNA1(5), FLT1(16), FLT4(24), KDR(13), NOS3(10), PDE2A(15), PDE3A(14), PDE3B(20), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), PRKG1(10), PRKG2(13), RYR2(82), SLC7A1(6), SYT1(4), TNNI1(2)	17362439	287	129	278	92	82	71	9	71	54	0	0.132	1.000	1.000
236	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	77	AIFM1(2), AKT1(3), AKT2(8), AKT3(6), APAF1(8), ATM(38), BAD(3), BAX(6), BCL2(3), BID(2), BIRC2(3), BIRC3(6), CAPN1(5), CAPN2(8), CASP10(6), CASP3(2), CASP6(1), CASP7(3), CASP9(3), CFLAR(1), CHUK(4), CSF2RB(9), DFFA(4), DFFB(3), FADD(1), FAS(3), FASLG(3), IKBKB(8), IL1A(2), IL1B(3), IL1R1(4), IL1RAP(7), IL3(1), IL3RA(5), IRAK1(6), IRAK2(7), IRAK3(6), IRAK4(3), MYD88(2), NFKB1(7), NFKB2(7), NFKBIA(1), NTRK1(10), PIK3CB(13), PIK3CD(11), PIK3CG(21), PIK3R1(11), PIK3R2(11), PIK3R3(8), PIK3R5(8), PPP3CA(10), PPP3CB(6), PPP3CC(5), PPP3R1(2), PRKACA(4), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), RELA(5), RIPK1(2), TNF(3), TNFRSF10A(1), TNFRSF10B(2), TNFRSF10C(3), TNFRSF10D(3), TNFRSF1A(6), TNFSF10(5), TRADD(2), TRAF2(4)	33998710	400	128	372	104	113	82	10	70	118	7	0.0339	1.000	1.000
237	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	27	BRAF(16), CPEB1(5), EGFR(15), ERBB2(15), ERBB4(48), ETS1(8), ETS2(4), ETV6(7), ETV7(5), FMN2(38), GRB2(4), MAP2K1(5), MAPK1(3), MAPK3(1), NOTCH1(26), NOTCH2(25), NOTCH3(22), NOTCH4(16), PIWIL1(6), PIWIL2(8), PIWIL3(5), PIWIL4(7), RAF1(10), SOS1(7), SOS2(19), SPIRE1(6), SPIRE2(4)	22213947	335	128	311	111	101	71	12	83	66	2	0.422	1.000	1.000
238	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	66	AKT1(3), AKT2(8), AKT3(6), BAD(3), CASP9(3), CDC42(1), KDR(13), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK11(1), MAPK13(3), MAPK14(1), MAPK3(1), MAPKAPK2(1), MAPKAPK3(5), NFAT5(10), NFATC1(13), NFATC2(17), NFATC3(4), NFATC4(16), NOS3(10), NRAS(3), PIK3CB(13), PIK3CD(11), PIK3CG(21), PIK3R1(11), PIK3R2(11), PIK3R3(8), PIK3R5(8), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G2A(2), PLA2G2D(1), PLA2G2E(4), PLA2G3(9), PLA2G4A(6), PLA2G5(1), PLA2G6(6), PLCG1(19), PLCG2(15), PPP3CA(10), PPP3CB(6), PPP3CC(5), PPP3R1(2), PRKCA(5), PRKCG(17), PTGS2(7), PTK2(11), PXN(4), RAC2(2), RAC3(4), RAF1(10), SH2D2A(7), SHC2(2), SPHK1(6), SPHK2(3), SRC(3)	29609532	388	128	370	110	131	87	14	74	80	2	0.0108	1.000	1.000
239	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	70	ACACB(35), ACSL1(3), ACSL3(8), ACSL4(4), ACSL5(7), ACSL6(6), ADIPOQ(3), ADIPOR1(5), ADIPOR2(4), AGRP(1), AKT1(3), AKT2(8), AKT3(6), CAMKK1(5), CAMKK2(2), CD36(2), CHUK(4), CPT1A(10), CPT1B(5), CPT1C(7), CPT2(5), G6PC2(1), IKBKB(8), IRS1(24), IRS2(6), IRS4(27), JAK1(12), JAK2(13), JAK3(13), LEP(2), LEPR(13), MAPK10(5), MAPK8(5), MAPK9(3), NFKB1(7), NFKB2(7), NFKBIA(1), NFKBIB(6), NPY(2), PCK1(11), PCK2(9), POMC(8), PPARA(4), PPARGC1A(10), PRKAA1(6), PRKAA2(7), PRKAB1(6), PRKAB2(4), PRKAG1(4), PRKAG2(5), PRKAG3(3), PRKCQ(10), PTPN11(6), RELA(5), RXRA(6), RXRB(4), RXRG(5), SLC2A1(6), SLC2A4(4), SOCS3(3), STAT3(7), STK11(3), TNF(3), TNFRSF1A(6), TNFRSF1B(3), TRADD(2), TRAF2(4), TYK2(9)	35581356	451	128	432	139	138	87	11	96	111	8	0.184	1.000	1.000
240	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	42	ACTR2(2), ACTR3(2), AKT1(3), AKT2(8), AKT3(6), ANGPTL2(4), ARHGAP1(4), ARHGAP4(4), ARHGEF11(18), BTK(3), CDC42(1), CFL1(1), CFL2(1), GDI1(3), GDI2(4), INPPL1(24), ITPR1(24), ITPR2(30), ITPR3(36), LIMK1(5), MYLK(22), MYLK2(4), PAK1(5), PAK2(7), PAK3(5), PAK4(8), PAK6(9), PAK7(9), PDK1(3), PIK3CD(11), PIK3CG(21), PIK3R1(11), PITX2(6), PPP1R13B(11), RACGAP1(7), RHO(7), ROCK1(18), ROCK2(12), RPS4X(1), SAG(4), WASF1(5), WASL(3)	28795949	372	128	353	103	124	85	17	52	83	11	0.0274	1.000	1.000
241	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	47	ADCY4(9), ADCY6(14), ADCY8(31), CACNA1A(24), CACNA1B(24), GNAS(29), GNAT3(5), GNB1(1), GNB3(1), GNG13(2), GRM4(11), ITPR3(36), KCNB1(12), PDE1A(7), PLCB2(8), PRKACA(4), PRKACB(4), PRKACG(8), PRKX(5), SCNN1B(7), SCNN1G(4), TAS1R1(7), TAS1R2(10), TAS1R3(8), TAS2R1(3), TAS2R13(3), TAS2R14(5), TAS2R16(9), TAS2R3(2), TAS2R38(5), TAS2R39(1), TAS2R4(5), TAS2R40(3), TAS2R41(2), TAS2R42(4), TAS2R43(2), TAS2R5(3), TAS2R50(1), TAS2R60(3), TAS2R7(4), TAS2R8(3), TAS2R9(1), TRPM5(6)	24153466	336	127	327	117	124	82	14	69	45	2	0.235	1.000	1.000
242	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	62	ATM(38), CCNA1(6), CCNB1(3), CCND1(1), CCND2(3), CCND3(2), CCNE1(5), CCNE2(3), CCNH(2), CDC25A(6), CDK2(3), CDKN1A(3), CDKN2D(3), CREB3L1(4), CREB3L3(4), CREB3L4(2), E2F1(3), E2F2(4), E2F3(3), E2F5(1), E2F6(2), GBA2(4), MCM2(14), MCM3(6), MCM4(13), MCM5(8), MCM6(8), MCM7(7), MDM2(5), MNAT1(3), MYC(5), MYT1(19), NACA(3), PCNA(2), POLA2(4), POLE(24), POLE2(4), PRIM1(2), RB1(13), RBL1(11), RPA1(2), RPA2(2), RPA3(2), TFDP1(5), TFDP2(4), TNXB(43), WEE1(4)	32517517	318	124	303	104	99	75	11	58	71	4	0.267	1.000	1.000
243	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(39), ASH2L(5), CARM1(5), CTCFL(11), DOT1L(11), EED(5), EHMT1(14), EHMT2(12), EZH1(5), EZH2(6), FBXO11(11), HCFC1(17), HSF4(7), JMJD4(1), JMJD6(3), KDM6A(12), MEN1(8), NSD1(24), OGT(5), PAXIP1(5), PPP1CA(2), PPP1CB(1), PPP1CC(5), PRDM2(30), PRDM7(2), PRDM9(18), PRMT1(3), PRMT5(3), PRMT6(4), PRMT7(6), PRMT8(9), RBBP5(3), SATB1(16), SETD1A(18), SETD2(17), SETD7(2), SETDB1(18), SETDB2(10), SETMAR(2), SMYD3(3), STK38(7), SUV39H1(5), SUV39H2(2), SUV420H1(11), SUV420H2(3), SUZ12(3), WHSC1(16), WHSC1L1(17)	50987438	442	123	423	129	120	108	15	79	109	11	0.184	1.000	1.000
244	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	83	ATF2(3), BRAF(16), CHUK(4), CREB1(3), DAXX(10), ELK1(3), FOS(1), GRB2(4), IKBKB(8), JUN(4), MAP2K1(5), MAP2K2(3), MAP2K3(4), MAP2K4(8), MAP2K5(1), MAP2K6(1), MAP3K1(11), MAP3K10(8), MAP3K11(7), MAP3K12(15), MAP3K13(9), MAP3K2(4), MAP3K3(8), MAP3K4(21), MAP3K5(5), MAP3K6(8), MAP3K7(10), MAP3K9(3), MAP4K1(4), MAP4K2(8), MAP4K3(4), MAP4K4(10), MAP4K5(1), MAPK1(3), MAPK10(5), MAPK11(1), MAPK13(3), MAPK14(1), MAPK3(1), MAPK4(6), MAPK6(1), MAPK7(6), MAPK8(5), MAPK9(3), MAPKAPK2(1), MAPKAPK3(5), MAPKAPK5(3), MAX(3), MEF2A(2), MEF2B(5), MEF2C(4), MEF2D(7), MKNK1(3), MKNK2(7), MYC(5), NFKB1(7), NFKBIA(1), PAK1(5), PAK2(7), RAF1(10), RELA(5), RIPK1(2), RPS6KA1(9), RPS6KA2(9), RPS6KA3(4), RPS6KA4(6), RPS6KA5(3), RPS6KB1(5), RPS6KB2(4), SHC1(7), SP1(6), STAT1(10), TGFB1(3), TGFB2(6), TGFB3(8), TGFBR1(4), TRADD(2), TRAF2(4)	40455701	421	123	408	143	120	97	19	71	109	5	0.461	1.000	1.000
245	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	45	AKT1(3), AKT2(8), AKT3(6), BAD(3), BCL2(3), BCR(11), BLNK(4), BTK(3), CD19(4), CD22(5), CD81(6), CR2(22), CSK(7), DAG1(13), FLOT1(2), FLOT2(5), GRB2(4), GSK3A(3), GSK3B(5), INPP5D(4), ITPR1(24), ITPR2(30), ITPR3(36), LYN(5), MAP4K1(4), MAPK1(3), MAPK3(1), NFATC1(13), NFATC2(17), NR0B2(3), PDK1(3), PIK3CD(11), PIK3R1(11), PLCG2(15), PPP1R13B(11), PPP3CA(10), PPP3CB(6), PPP3CC(5), PTPRC(19), RAF1(10), SHC1(7), SOS1(7), SOS2(19), SYK(7), VAV1(9)	30816252	407	123	385	122	134	94	8	77	88	6	0.0579	1.000	1.000
246	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	60	AKT1(3), AKT2(8), AKT3(6), BCL10(2), BLNK(4), BTK(3), CARD11(20), CD19(4), CD22(5), CD72(1), CD79A(6), CD79B(2), CD81(6), CHUK(4), CR2(22), FCGR2B(1), FOS(1), GSK3B(5), IFITM1(1), IKBKB(8), INPP5D(4), JUN(4), LILRB3(2), LYN(5), MALT1(4), NFAT5(10), NFATC1(13), NFATC2(17), NFATC3(4), NFATC4(16), NFKB1(7), NFKB2(7), NFKBIA(1), NFKBIB(6), NRAS(3), PIK3CB(13), PIK3CD(11), PIK3CG(21), PIK3R1(11), PIK3R2(11), PIK3R3(8), PIK3R5(8), PLCG2(15), PPP3CA(10), PPP3CB(6), PPP3CC(5), PPP3R1(2), PTPN6(4), RAC2(2), RAC3(4), RASGRP3(5), SYK(7), VAV1(9), VAV2(12), VAV3(10)	30829916	389	122	368	126	126	90	8	75	88	2	0.208	1.000	1.000
247	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	64	ADAM10(3), ADAM17(6), ATP6AP1(6), ATP6V0A1(5), ATP6V0A2(7), ATP6V0A4(10), ATP6V0B(4), ATP6V0D1(8), ATP6V0D2(2), ATP6V1A(6), ATP6V1B2(5), ATP6V1C1(2), ATP6V1C2(12), ATP6V1D(3), ATP6V1E1(2), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(7), CASP3(2), CCL5(2), CDC42(1), CHUK(4), CSK(7), EGFR(15), F11R(2), GIT1(3), HBEGF(1), IGSF5(3), IKBKB(8), JAM2(2), JAM3(7), JUN(4), LYN(5), MAP2K4(8), MAPK10(5), MAPK11(1), MAPK13(3), MAPK14(1), MAPK8(5), MAPK9(3), MET(8), NFKB1(7), NFKB2(7), NFKBIA(1), NOD1(11), PAK1(5), PLCG1(19), PLCG2(15), PTPN11(6), PTPRZ1(25), RELA(5), SRC(3), TCIRG1(7), TJP1(21)	29703045	325	121	315	113	84	74	10	75	80	2	0.597	1.000	1.000
248	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	70	AKT1(3), AKT2(8), AKT3(6), BTK(3), FCER1A(3), FYN(10), GAB2(3), GRB2(4), IL13(2), IL3(1), IL4(1), INPP5D(4), LAT(3), LCP2(7), LYN(5), MAP2K1(5), MAP2K2(3), MAP2K3(4), MAP2K4(8), MAP2K6(1), MAPK1(3), MAPK10(5), MAPK11(1), MAPK13(3), MAPK14(1), MAPK3(1), MAPK8(5), MAPK9(3), MS4A2(2), NRAS(3), PDK1(3), PIK3CB(13), PIK3CD(11), PIK3CG(21), PIK3R1(11), PIK3R2(11), PIK3R3(8), PIK3R5(8), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G2A(2), PLA2G2D(1), PLA2G2E(4), PLA2G3(9), PLA2G4A(6), PLA2G5(1), PLA2G6(6), PLCG1(19), PLCG2(15), PRKCA(5), PRKCD(7), PRKCE(14), RAC2(2), RAC3(4), RAF1(10), SOS1(7), SOS2(19), SYK(7), TNF(3), VAV1(9), VAV2(12), VAV3(10)	29353214	374	118	360	116	114	93	10	74	78	5	0.157	1.000	1.000
249	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	50	ACTA1(3), AGT(3), AKT1(3), CALM1(2), CALM2(2), CALR(5), CAMK1(3), CAMK1G(6), CAMK4(8), CREBBP(40), CSNK1A1(3), EDN1(3), ELSPBP1(3), F2(9), FGF2(2), FKBP1A(2), GATA4(4), GSK3B(5), HAND1(3), HAND2(2), IGF1(4), LIF(2), MAP2K1(5), MAPK1(3), MAPK14(1), MAPK3(1), MAPK8(5), MEF2C(4), MYH2(29), NFATC1(13), NFATC2(17), NFATC3(4), NFATC4(16), NKX2-5(4), NPPA(2), PIK3R1(11), PPP3CA(10), PPP3CB(6), PPP3CC(5), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), RAF1(10), RPS6KB1(5), SYT1(4)	20830824	303	118	291	90	103	66	11	52	69	2	0.0222	1.000	1.000
250	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT1(3), AKT2(8), AKT3(6), ANKRD6(6), APC(43), AXIN1(9), AXIN2(15), CER1(2), CSNK1A1(3), CTNNB1(22), DACT1(10), DKK1(9), DKK2(5), DKK3(3), DKK4(3), DVL1(7), FSTL1(3), GSK3A(3), GSK3B(5), LRP1(47), MVP(7), NKD1(10), NKD2(1), PIN1(2), PSEN1(3), PTPRA(12), SENP2(4), SFRP1(4), TSHB(3), WIF1(2)	17297677	260	118	238	80	78	60	4	44	62	12	0.357	1.000	1.000
251	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	60	APAF1(8), ATM(38), ATR(18), BAI1(14), BAX(6), BID(2), CASP3(2), CASP9(3), CCNB1(3), CCNB2(1), CCNB3(20), CCND1(1), CCND2(3), CCND3(2), CCNE1(5), CCNE2(3), CD82(3), CDK2(3), CDK6(4), CDKN1A(3), CHEK1(4), CHEK2(8), DDB2(2), EI24(1), FAS(3), GADD45B(1), GTSE1(3), IGF1(4), IGFBP3(6), MDM2(5), MDM4(4), PERP(3), PPM1D(9), RCHY1(1), RFWD2(7), RPRM(5), RRM2(4), RRM2B(4), SERPINB5(3), SERPINE1(3), SESN1(3), SESN2(2), SESN3(4), SFN(1), SIAH1(2), STEAP3(9), THBS1(16), TNFRSF10B(2), TP53I3(1), TP73(5), TSC2(12), ZMAT3(4)	26539030	283	116	268	87	76	76	4	55	67	5	0.265	1.000	1.000
252	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	49	ABL1(7), ACTB(8), ACTG1(1), ARHGEF2(11), ARPC5L(1), CD14(2), CDC42(1), CLDN1(3), CTNNB1(22), CTTN(7), EZR(6), FYN(10), HCLS1(3), ITGB1(10), KRT18(2), LY96(4), NCK1(6), NCK2(5), NCL(7), OCLN(6), PRKCA(5), ROCK1(18), ROCK2(12), TLR4(21), TLR5(10), TUBA1A(2), TUBA1B(1), TUBA1C(1), TUBA3C(8), TUBA3D(7), TUBA3E(8), TUBA4A(1), TUBA8(5), TUBAL3(5), TUBB1(5), TUBB2A(3), TUBB2B(3), TUBB3(7), TUBB6(7), TUBB8(2), WAS(3), WASL(3), YWHAQ(2), YWHAZ(3)	21655457	264	116	252	86	67	73	7	64	50	3	0.287	1.000	1.000
253	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	49	ABL1(7), ACTB(8), ACTG1(1), ARHGEF2(11), ARPC5L(1), CD14(2), CDC42(1), CLDN1(3), CTNNB1(22), CTTN(7), EZR(6), FYN(10), HCLS1(3), ITGB1(10), KRT18(2), LY96(4), NCK1(6), NCK2(5), NCL(7), OCLN(6), PRKCA(5), ROCK1(18), ROCK2(12), TLR4(21), TLR5(10), TUBA1A(2), TUBA1B(1), TUBA1C(1), TUBA3C(8), TUBA3D(7), TUBA3E(8), TUBA4A(1), TUBA8(5), TUBAL3(5), TUBB1(5), TUBB2A(3), TUBB2B(3), TUBB3(7), TUBB6(7), TUBB8(2), WAS(3), WASL(3), YWHAQ(2), YWHAZ(3)	21655457	264	116	252	86	67	73	7	64	50	3	0.287	1.000	1.000
254	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CD2BP2(3), CDC40(8), CLK2(11), CLK3(12), CLK4(4), COL2A1(16), CPSF1(18), CPSF2(4), CPSF3(3), CPSF4(3), CSTF1(8), CSTF2(5), CSTF2T(7), CSTF3(8), DDIT3(4), DDX1(7), DDX20(4), DHX15(10), DHX16(6), DHX38(16), DHX8(14), DHX9(7), DICER1(11), DNAJC8(4), GIPC1(4), NCBP1(5), NCBP2(3), NONO(4), NUDT21(2), NXF1(7), PABPN1(1), PAPOLA(5), PHF5A(1), POLR2A(19), PPM1G(4), PRPF18(2), PRPF3(6), PRPF4(6), PRPF4B(11), PRPF8(16), PSKH1(7), PTBP1(7), PTBP2(2), RBM17(2), RBM5(8), RNGTT(4), RNMT(9), SF3A1(3), SF3A2(2), SF3A3(3), SF3B1(6), SF3B2(17), SF3B4(6), SNRPA(8), SNRPA1(4), SNRPB(2), SNRPB2(2), SNRPD1(2), SNRPD2(5), SNRPD3(4), SNRPE(2), SNRPG(1), SNRPN(8), SPOP(3), SRPK1(3), SRPK2(8), SRRM1(12), SUPT5H(13), U2AF1(4), U2AF2(10), XRN2(15)	45433080	471	116	454	126	150	119	19	68	110	5	0.0422	1.000	1.000
255	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	64	AGTR1(2), AGTR2(4), ATP8A1(8), AVPR1A(14), AVPR1B(3), AVPR2(6), BDKRB1(2), BDKRB2(4), BRS3(3), C3AR1(8), CCKAR(5), CCKBR(9), CCR1(5), CCR10(1), CCR2(6), CCR3(6), CCR5(4), CCR6(1), CCR7(3), CCR8(3), CX3CR1(3), CXCR3(1), CXCR4(1), CXCR6(2), EDNRA(4), FPR1(6), GALR1(6), GALR2(10), GALR3(2), GALT(1), GHSR(9), GNB2L1(4), GNRHR(4), GRPR(6), LHCGR(11), MC1R(6), MC2R(2), MC3R(9), MC4R(5), MC5R(5), NMBR(4), NPY1R(4), NPY2R(6), NPY5R(4), NTSR1(7), NTSR2(4), OPRD1(2), OPRK1(14), OPRL1(6), OPRM1(4), OXTR(7), SSTR1(9), SSTR2(4), SSTR3(8), SSTR4(14), TAC4(3), TACR1(3), TACR2(1), TACR3(15), TRHR(5), TSHR(10)	21493599	328	116	316	129	127	88	9	55	48	1	0.291	1.000	1.000
256	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	ACVR1(5), APC(43), ATF2(3), AXIN1(9), BMP10(4), BMP2(5), BMP4(6), BMP5(11), BMP7(7), BMPR1A(5), BMPR2(16), CHRD(9), CTNNB1(22), DVL1(7), FZD1(10), GATA4(4), GSK3B(5), MAP3K7(10), MEF2C(4), MYL2(8), NKX2-5(4), NOG(1), NPPA(2), NPPB(2), RFC1(10), TGFB1(3), TGFB2(6), TGFB3(8), TGFBR1(4), TGFBR2(14), TGFBR3(7), WNT1(8)	15607883	262	115	251	75	64	62	9	44	72	11	0.186	1.000	1.000
257	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	55	ADH1A(4), ADH1B(4), ADH4(2), ADH5(3), ADH6(7), ADH7(1), ADHFE1(9), ALDH1A3(6), ALDH3A1(11), ALDH3B1(4), ALDH3B2(7), AOC2(6), AOC3(15), AOX1(12), CARM1(5), COMT(4), DBH(6), DCT(13), ECH1(2), ESCO1(7), ESCO2(8), FAH(8), GOT1(3), GOT2(2), GSTZ1(3), HEMK1(1), HGD(4), HPD(1), LCMT1(1), LCMT2(11), MAOA(2), MAOB(3), METTL6(3), MIF(1), NAT6(3), PNMT(8), PNPLA3(2), PRMT2(8), PRMT3(5), PRMT5(3), PRMT6(4), PRMT7(6), PRMT8(9), SH3GLB1(3), TAT(5), TH(3), TPO(24), TYR(9), TYRP1(4), WBSCR22(6)	25073677	281	115	257	86	74	57	6	63	75	6	0.380	1.000	1.000
258	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	45	FN3K(3), IMPA1(4), IMPA2(2), INPP1(1), INPP4A(6), INPP4B(7), INPP5A(8), INPP5B(7), INPP5E(6), INPPL1(24), IPMK(1), ISYNA1(3), ITPK1(4), ITPKA(2), ITPKB(11), MINPP1(5), MIOX(5), OCRL(9), PI4KA(14), PI4KB(5), PIK3C3(14), PIK3CB(13), PIK3CD(11), PIK3CG(21), PIP4K2A(6), PIP4K2B(4), PIP4K2C(2), PIP5K1A(4), PIP5K1B(1), PIP5K1C(11), PLCB1(19), PLCB2(8), PLCB3(12), PLCB4(13), PLCD1(4), PLCD3(9), PLCD4(5), PLCE1(14), PLCG1(19), PLCG2(15), PLCZ1(6), PTPMT1(1), SYNJ1(10), SYNJ2(18)	30553150	367	115	344	110	129	87	7	67	76	1	0.0512	1.000	1.000
259	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	85	AICDA(3), AK3(5), CAD(17), CANT1(4), CTPS2(4), DCTD(1), DHODH(3), DPYD(16), DPYS(7), DUT(2), ENTPD1(5), ENTPD3(5), ENTPD4(8), ENTPD5(3), ENTPD6(4), ENTPD8(6), ITPA(1), NME2(3), NME6(3), NME7(1), NT5C(1), NT5C1A(5), NT5C1B(6), NT5C2(8), NT5E(2), NUDT2(4), PNPT1(5), POLA1(6), POLA2(4), POLD1(15), POLD2(4), POLD3(7), POLE(24), POLE2(4), POLE3(3), POLR1A(15), POLR1B(8), POLR1C(3), POLR1D(4), POLR2A(19), POLR2B(11), POLR2C(4), POLR2E(2), POLR2F(4), POLR2G(1), POLR2I(2), POLR2K(1), POLR3A(17), POLR3B(13), POLR3G(2), POLR3K(1), PRIM1(2), PRIM2(1), RFC5(1), RRM1(5), RRM2(4), RRM2B(4), TK1(1), TK2(3), TXNRD1(6), TXNRD2(3), TYMS(1), UCK1(5), UCK2(1), UMPS(4), UPB1(4), UPP1(1), UPP2(7), UPRT(6), ZNRD1(1)	34589561	366	113	359	108	125	87	12	64	75	3	0.0340	1.000	1.000
260	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	33	AKT1(3), AKT2(8), AKT3(6), ASAH1(4), BRAF(16), DAG1(13), DRD2(9), EGFR(15), EPHB2(12), GRB2(4), ITPKA(2), ITPKB(11), ITPR1(24), ITPR2(30), ITPR3(36), KCNJ5(5), KCNJ9(2), MAPK1(3), PI3(2), PIK3CB(13), PITX2(6), PLCB1(19), PLCB2(8), PLCB3(12), PLCB4(13), RAF1(10), RGS20(6), SHC1(7), SOS1(7), SOS2(19), SRC(3), STAT3(7), TERF2IP(5)	24667306	340	113	325	113	116	79	11	63	67	4	0.322	1.000	1.000
261	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	30	AKT1(3), AKT2(8), AKT3(6), BCR(11), BTK(3), CD19(4), DAPP1(1), FLOT1(2), FLOT2(5), GAB1(3), ITPR1(24), ITPR2(30), ITPR3(36), LYN(5), NR0B2(3), PDK1(3), PHF11(4), PITX2(6), PLCG2(15), PPP1R13B(11), PREX1(16), PTPRC(19), RPS6KA1(9), RPS6KA2(9), RPS6KA3(4), RPS6KB1(5), SAG(4), SYK(7), TEC(4), VAV1(9)	22141852	269	112	262	99	95	62	7	53	47	5	0.587	1.000	1.000
262	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(4), ADH1B(4), ADH4(2), ADH5(3), ADH6(7), ADH7(1), ADHFE1(9), AGK(6), AGPAT1(3), AGPAT2(2), AGPAT3(4), AGPAT4(5), AGPAT6(5), AKR1A1(1), AKR1B1(6), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), CEL(10), DAK(8), DGAT1(3), DGAT2(1), DGKA(7), DGKB(11), DGKD(6), DGKE(7), DGKG(4), DGKH(10), DGKI(16), DGKQ(2), DGKZ(8), GK(3), GK2(7), GLA(3), GLB1(5), GPAM(10), LCT(23), LIPA(3), LIPC(4), LIPF(5), LIPG(4), LPL(7), MGLL(1), PNLIP(4), PNLIPRP1(4), PNPLA3(2), PPAP2A(3), PPAP2B(1), PPAP2C(4)	25140442	293	111	282	98	79	77	9	58	68	2	0.309	1.000	1.000
263	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	43	AKT1(3), AKT2(8), AKT3(6), BRAF(16), CAB39(1), EIF4B(5), EIF4EBP1(2), FIGF(4), HIF1A(7), IGF1(4), MAPK1(3), MAPK3(1), PDPK1(2), PGF(1), PIK3CB(13), PIK3CD(11), PIK3CG(21), PIK3R1(11), PIK3R2(11), PIK3R3(8), PIK3R5(8), PRKAA1(6), PRKAA2(7), RHEB(1), RICTOR(19), RPS6(1), RPS6KA1(9), RPS6KA2(9), RPS6KA3(4), RPS6KA6(15), RPS6KB1(5), RPS6KB2(4), STK11(3), TSC1(7), TSC2(12), ULK1(16), ULK2(11), VEGFB(1), VEGFC(9)	21801263	285	111	266	86	98	58	11	50	66	2	0.275	1.000	1.000
264	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(43), AXIN1(9), CREBBP(40), CTNNB1(22), DVL1(7), EP300(22), FZD1(10), GSK3B(5), HDAC1(5), LDB1(5), LEF1(8), PITX2(6), TRRAP(50), WNT1(8)	14224454	240	110	227	64	75	52	6	39	58	10	0.0334	1.000	1.000
265	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	49	ACOX1(5), APOA1(8), CD36(2), CITED2(3), CPT1B(5), CREBBP(40), DUSP1(2), DUT(2), EHHADH(7), EP300(22), HSD17B4(7), HSPA1A(2), JUN(4), LPL(7), MAPK1(3), MAPK3(1), ME1(2), MYC(5), NCOA1(17), NCOR1(26), NCOR2(30), NFKBIA(1), NR0B2(3), NR1H3(6), NR2F1(7), NRIP1(17), PDGFA(2), PIK3R1(11), PPARA(4), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), PRKCA(5), PTGS2(7), RB1(13), RELA(5), RXRA(6), SP1(6), STAT5A(3), STAT5B(14), TNF(3)	26171716	344	110	331	103	88	90	9	64	90	3	0.104	1.000	1.000
266	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	63	ACHE(11), AGPAT1(3), AGPAT2(2), AGPAT3(4), AGPAT4(5), AGPAT6(5), CDIPT(1), CDS1(6), CDS2(2), CHAT(4), CHKA(2), CHKB(2), CHPT1(3), CRLS1(1), DGKA(7), DGKB(11), DGKD(6), DGKE(7), DGKG(4), DGKH(10), DGKI(16), DGKQ(2), DGKZ(8), ESCO1(7), ESCO2(8), ETNK1(2), ETNK2(1), GNPAT(1), GPAM(10), GPD1(7), GPD1L(4), GPD2(7), LCAT(4), LYPLA1(1), LYPLA2(2), NAT6(3), PCYT1A(9), PCYT1B(6), PEMT(1), PHOSPHO1(1), PISD(5), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G2A(2), PLA2G2D(1), PLA2G2E(4), PLA2G3(9), PLA2G4A(6), PLA2G5(1), PLA2G6(6), PLD1(19), PLD2(16), PNPLA3(2), PPAP2A(3), PPAP2B(1), PPAP2C(4), PTDSS1(4), PTDSS2(3), SH3GLB1(3)	27922723	290	109	285	99	93	70	9	55	61	2	0.359	1.000	1.000
267	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(29), COL4A2(13), COL4A3(13), COL4A4(15), COL4A5(14), COL4A6(9), F10(7), F11(4), F12(3), F2(9), F2R(3), F5(21), F8(22), F9(9), FGA(9), FGB(4), FGG(3), KLKB1(7), PROC(3), PROS1(9), SERPINC1(4), SERPING1(7)	19074452	217	109	214	67	51	55	7	62	41	1	0.150	1.000	1.000
268	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	32	AKT1(3), APC(43), AR(14), ASAH1(4), BRAF(16), CAMP(2), CCL15(2), CCL16(1), DAG1(13), EGFR(15), GNA11(6), GNA15(3), GNAI1(1), GNAQ(4), ITPKA(2), ITPKB(11), ITPR1(24), ITPR2(30), ITPR3(36), KCNJ5(5), KCNJ9(2), MAPK1(3), MAPK10(5), MAPK14(1), PHKA2(10), PIK3CD(11), PIK3R1(11), PITX2(6), PTX3(2), RAF1(10), SRC(3)	21528829	299	109	284	95	96	64	14	52	61	12	0.155	1.000	1.000
269	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	43	CBL(3), CD28(1), CSK(7), CTLA4(3), DAG1(13), EPHB2(12), GRAP2(4), GRB2(4), ITK(6), ITPKA(2), ITPKB(11), LAT(3), LCK(4), LCP2(7), MAPK1(3), NCK1(6), NFAT5(10), NFKB1(7), NFKB2(7), NFKBIA(1), NFKBIB(6), NFKBIL1(4), PAK1(5), PAK2(7), PAK3(5), PAK4(8), PAK6(9), PAK7(9), PLCG1(19), PTPRC(19), RAF1(10), RASGRP1(8), RASGRP2(7), RASGRP3(5), RASGRP4(4), SOS1(7), SOS2(19), VAV1(9), ZAP70(14)	23227824	288	109	278	90	92	69	9	60	56	2	0.222	1.000	1.000
270	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(3), ACTN1(7), ACTN2(23), BCAR1(8), BCR(11), CAPN1(5), CAPNS1(2), CAPNS2(2), CAV1(4), CRKL(1), CSK(7), FYN(10), GRB2(4), ITGA1(8), ITGB1(10), JUN(4), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK3(1), MAPK8(5), PPP1R12B(15), PTK2(11), PXN(4), RAF1(10), RAP1A(2), ROCK1(18), SHC1(7), SOS1(7), SRC(3), TLN1(23), VCL(6), ZYX(7)	20180510	239	108	230	75	82	57	9	47	41	3	0.0922	1.000	1.000
271	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	22	ADRB1(7), AKT1(3), APC(43), ASAH1(4), CAMP(2), CAV3(2), DAG1(13), DLG4(3), EPHB2(12), GNAI1(1), GNAQ(4), ITPR1(24), ITPR2(30), ITPR3(36), KCNJ5(5), KCNJ9(2), MAPK1(3), PITX2(6), PTX3(2), RHO(7), RYR1(61)	19250329	270	108	263	93	98	56	9	47	48	12	0.243	1.000	1.000
272	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	50	ACTG1(1), APAF1(8), ARHGDIB(1), BAG4(2), BCL2(3), BID(2), BIRC2(3), BIRC3(6), CASP2(3), CASP3(2), CASP6(1), CASP7(3), CASP9(3), CFLAR(1), CHUK(4), CRADD(1), DAXX(10), DFFA(4), DFFB(3), FADD(1), GSN(11), LMNA(6), LMNB1(4), LMNB2(6), MAP3K1(11), MAP3K5(5), MAPK8(5), MDM2(5), NFKB1(7), NFKBIA(1), NUMA1(22), PAK2(7), PRKCD(7), PRKDC(40), PSEN1(3), PSEN2(2), PTK2(11), RASA1(17), RB1(13), RELA(5), RIPK1(2), SPTAN1(21), TNF(3), TNFRSF1A(6), TNFRSF1B(3), TRADD(2), TRAF1(3), TRAF2(4)	28835914	294	107	286	97	81	76	15	46	73	3	0.415	1.000	1.000
273	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(13), AR(14), ESR1(9), ESR2(9), ESRRA(2), HNF4A(7), NR0B1(5), NR1D1(5), NR1D2(6), NR1H2(7), NR1H3(6), NR1I2(7), NR1I3(4), NR2C2(3), NR2E1(3), NR2F1(7), NR2F2(3), NR2F6(3), NR3C1(6), NR4A1(4), NR4A2(12), NR5A1(5), NR5A2(5), PGR(14), PPARA(4), PPARD(8), PPARG(4), RARA(3), RARB(7), RARG(1), ROR1(10), RORA(5), RORC(6), RXRA(6), RXRB(4), RXRG(5), THRA(6), THRB(9), VDR(2)	18034824	239	107	233	99	87	50	13	49	39	1	0.840	1.000	1.000
274	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	54	AK3(5), CAD(17), CANT1(4), CTPS2(4), DCTD(1), DHODH(3), DPYD(16), DPYS(7), DUT(2), ENTPD1(5), ITPA(1), NME2(3), NT5C(1), NT5E(2), NUDT2(4), POLB(4), POLD1(15), POLD2(4), POLE(24), POLG(8), POLL(3), POLQ(29), POLR1B(8), POLR2A(19), POLR2B(11), POLR2C(4), POLR2E(2), POLR2F(4), POLR2G(1), POLR2I(2), POLR2K(1), POLRMT(9), RRM1(5), RRM2(4), TK1(1), TK2(3), TXNRD1(6), TYMS(1), UCK1(5), UCK2(1), UMPS(4), UNG(2), UPB1(4), UPP1(1)	24438612	260	107	256	82	72	65	10	54	56	3	0.196	1.000	1.000
275	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	45	AKT1(3), AKT2(8), AKT3(6), BRD4(11), CAP1(2), CBL(3), CDC42(1), F2RL2(3), FLOT1(2), FLOT2(5), GRB2(4), GSK3A(3), GSK3B(5), INPPL1(24), IRS1(24), IRS2(6), IRS4(27), LNPEP(11), MAPK1(3), MAPK3(1), PARD3(11), PARD6A(1), PDK1(3), PIK3CD(11), PIK3R1(11), PTPN1(3), RAF1(10), RPS6KA1(9), RPS6KA2(9), RPS6KA3(4), RPS6KB1(5), SERPINB6(4), SFN(1), SHC1(7), SLC2A4(4), SORBS1(9), SOS1(7), SOS2(19), YWHAB(2), YWHAE(2), YWHAG(1), YWHAH(3), YWHAQ(2), YWHAZ(3)	23837686	293	107	274	87	105	65	3	41	75	4	0.135	1.000	1.000
276	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG1(1), ACTG2(9), ACTR2(2), ACTR3(2), AKT1(3), ANGPTL2(4), CDC42(1), CFL1(1), CFL2(1), FLNA(26), FLNC(26), FSCN1(5), FSCN3(11), GDI1(3), GDI2(4), LIMK1(5), MYH2(29), MYLK(22), MYLK2(4), PAK1(5), PAK2(7), PAK3(5), PAK4(8), PAK6(9), PAK7(9), PFN2(2), RHO(7), ROCK1(18), ROCK2(12), RPS4X(1), VASP(2), WASF1(5), WASL(3)	20534986	252	107	246	85	92	61	8	42	44	5	0.192	1.000	1.000
277	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(14), GABBR1(16), GPRC5B(8), GPRC5C(3), GPRC5D(2), GRM1(31), GRM2(23), GRM3(17), GRM4(11), GRM5(26), GRM7(20), GRM8(22)	9011198	193	105	184	75	82	30	11	42	28	0	0.481	1.000	1.000
278	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(6), ALPL(8), ALPP(7), ALPPL2(5), ASCC3(31), ATP13A2(13), DDX18(10), DDX19A(5), DDX23(8), DDX4(5), DDX41(8), DDX47(2), DDX50(11), DDX51(5), DDX52(3), DDX54(18), DDX55(5), DDX56(5), DHX58(9), ENTPD7(11), EP400(35), ERCC2(8), ERCC3(8), FPGS(4), GCH1(1), GGH(3), IFIH1(8), MOV10L1(6), QDPR(3), RAD54B(3), RAD54L(5), RUVBL2(5), SETX(20), SKIV2L2(8), SMARCA2(22), SMARCA5(7), SPR(2)	26941169	323	104	317	110	112	70	8	62	68	3	0.507	1.000	1.000
279	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	A4GALT(3), B3GALNT1(3), B3GALT1(3), B3GALT2(7), B3GALT4(7), B3GALT5(1), B3GNT1(3), B3GNT2(3), B3GNT3(5), B3GNT4(7), B3GNT5(10), B4GALNT1(5), B4GALT1(2), B4GALT2(7), B4GALT3(2), B4GALT4(5), B4GALT6(4), FUT1(3), FUT2(1), FUT3(3), FUT4(2), FUT5(3), FUT6(4), FUT7(2), FUT9(6), GBGT1(3), GCNT2(2), PIGA(3), PIGB(10), PIGC(6), PIGF(1), PIGG(12), PIGK(3), PIGL(4), PIGM(5), PIGN(7), PIGO(12), PIGP(1), PIGQ(7), PIGS(4), PIGT(8), PIGU(1), PIGV(7), PIGX(2), PIGZ(4), ST3GAL1(4), ST3GAL2(6), ST3GAL3(2), ST3GAL4(6), ST3GAL5(3), ST3GAL6(4), ST6GALNAC3(8), ST6GALNAC4(2), ST6GALNAC5(3), ST6GALNAC6(4), ST8SIA1(7), ST8SIA5(8), UGCG(3)	20790706	263	103	244	91	86	50	6	47	71	3	0.758	1.000	1.000
280	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(5), AASDHPPT(1), AASS(7), ACAT1(5), ACAT2(4), AKR1B10(6), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), BBOX1(4), DLST(4), DOT1L(11), EHHADH(7), EHMT1(14), EHMT2(12), GCDH(8), HADH(3), HADHA(4), HSD17B4(7), HSD3B7(6), NSD1(24), OGDH(11), OGDHL(16), PIPOX(3), PLOD1(7), PLOD2(12), PLOD3(16), RDH11(1), RDH12(3), RDH13(5), SETD1A(18), SETD7(2), SETDB1(18), SHMT1(2), SHMT2(9), SPCS1(2), SPCS3(2), SUV39H1(5), SUV39H2(2), TMLHE(5)	24889355	316	102	292	92	96	74	9	51	83	3	0.119	1.000	1.000
281	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	57	AADAT(5), AANAT(2), ACAT1(5), ACAT2(4), ACMSD(5), AFMID(3), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), AOC2(6), AOC3(15), AOX1(12), ASMT(3), CARM1(5), CAT(5), CYP1A1(5), CYP1A2(5), CYP1B1(2), EHHADH(7), GCDH(8), HAAO(1), HADH(3), HADHA(4), HEMK1(1), HSD17B4(7), INMT(3), KMO(4), KYNU(11), LCMT1(1), LCMT2(11), LNX1(3), MAOA(2), MAOB(3), METTL6(3), NFX1(5), OGDH(11), OGDHL(16), PRMT2(8), PRMT3(5), PRMT5(3), PRMT6(4), PRMT7(6), PRMT8(9), TDO2(7), TPH1(3), TPH2(7), WARS(5), WARS2(10), WBSCR22(6)	25538240	304	102	276	96	75	72	11	50	90	6	0.419	1.000	1.000
282	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	31	ACTR2(2), ACTR3(2), AKT1(3), ANGPTL2(4), DAG1(13), DGKA(7), ETFA(1), GCA(2), ITGA9(8), ITPKA(2), ITPKB(11), ITPR1(24), ITPR2(30), ITPR3(36), MAP2K1(5), MAPK1(3), MAPK3(1), NR1I3(4), PAK1(5), PDE3A(14), PDE3B(20), PI3(2), PIK3C2G(10), PIK3CD(11), PIK3R1(11), PSME1(3), RIPK3(5), RPS4X(1), SGCB(4), VASP(2)	19922709	246	102	236	73	77	60	9	46	50	4	0.0603	1.000	1.000
283	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	40	AKT1(3), ASAH1(4), BRAF(16), CAMP(2), CREB1(3), CREB5(5), CREBBP(40), CRKL(1), DAG1(13), EGR1(10), EGR2(8), EGR3(6), EGR4(6), ELK1(3), FRS2(4), GNAQ(4), JUN(4), MAP1B(20), MAP2K4(8), MAPK1(3), MAPK10(5), MAPK3(1), MAPK8(5), MAPK8IP1(4), MAPK8IP2(4), MAPK8IP3(13), MAPK9(3), NTRK1(10), OPN1LW(6), PIK3C2G(10), PIK3CD(11), PIK3R1(11), PTPN11(6), RPS6KA3(4), SHC1(7), SRC(3), TERF2IP(5), TH(3)	20776834	274	102	260	88	88	65	4	49	65	3	0.161	1.000	1.000
284	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	40	AGL(16), AMY2A(3), ENPP1(7), ENPP3(8), GAA(5), GANAB(12), GBE1(5), GCK(4), GPI(5), GUSB(11), GYS1(6), GYS2(6), HK1(16), HK2(10), HK3(6), MGAM(15), PGM1(2), PGM3(7), PYGB(10), PYGL(8), PYGM(14), SI(27), UCHL1(1), UCHL3(3), UGDH(5), UGT1A1(4), UGT1A10(1), UGT1A3(1), UGT1A4(3), UGT1A5(3), UGT1A6(6), UGT1A7(3), UGT1A9(3), UGT2B15(3), UGT2B4(4), UXS1(5)	23900373	248	102	244	83	63	71	6	50	58	0	0.362	1.000	1.000
285	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	41	CALM1(2), CALM2(2), CD3E(2), CD3G(1), ELK1(3), FOS(1), FYN(10), GRB2(4), JUN(4), LAT(3), LCK(4), MAP2K1(5), MAP2K4(8), MAP3K1(11), MAPK3(1), MAPK8(5), NFATC1(13), NFATC2(17), NFATC3(4), NFATC4(16), NFKB1(7), NFKBIA(1), PIK3R1(11), PLCG1(19), PPP3CA(10), PPP3CB(6), PPP3CC(5), PRKCA(5), PTPN7(7), RAF1(10), RASA1(17), RELA(5), SHC1(7), SOS1(7), SYT1(4), VAV1(9), ZAP70(14)	19599314	260	102	249	63	83	59	6	38	70	4	0.00531	1.000	1.000
286	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	53	AANAT(2), ACAT1(5), ACAT2(4), ACMSD(5), ALDH1A1(7), ALDH1A2(5), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), AOC2(6), AOC3(15), AOX1(12), ASMT(3), CAT(5), CYP19A1(13), CYP1A1(5), CYP1A2(5), CYP2A13(8), CYP2A6(7), CYP2A7(3), CYP2B6(6), CYP2C18(4), CYP2C19(7), CYP2C8(1), CYP2D6(9), CYP2E1(6), CYP2F1(4), CYP2J2(3), CYP3A4(4), CYP3A7(4), CYP4B1(9), CYP51A1(8), EHHADH(7), GCDH(8), HAAO(1), HADHA(4), KMO(4), KYNU(11), MAOA(2), MAOB(3), SDS(4), TDO2(7), TPH1(3), WARS(5), WARS2(10)	23202205	289	101	267	82	79	65	5	58	79	3	0.194	1.000	1.000
287	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	AGXT(1), AGXT2(8), AKR1B10(6), ALAS1(3), ALAS2(12), AMT(4), AOC2(6), AOC3(15), BHMT(5), CBS(6), CHDH(6), CHKA(2), CHKB(2), CTH(2), DAO(11), DLD(4), DMGDH(6), GAMT(1), GARS(4), GATM(3), GCAT(4), GLDC(8), GNMT(4), HSD3B7(6), MAOA(2), MAOB(3), PEMT(1), PHGDH(3), PIPOX(3), PISD(5), PSAT1(5), PSPH(2), RDH11(1), RDH12(3), RDH13(5), SARDH(13), SARS(8), SARS2(7), SDS(4), SHMT1(2), SHMT2(9), TARS(7), TARS2(7)	18301593	219	100	207	73	68	53	13	39	45	1	0.370	1.000	1.000
288	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACAA1(3), ACADL(2), ACADM(4), ACOX1(5), ACOX2(6), ACOX3(11), ACSL1(3), ACSL3(8), ACSL4(4), ACSL5(7), ACSL6(6), ADIPOQ(3), ANGPTL4(2), APOA1(8), APOA5(4), AQP7(2), CD36(2), CPT1A(10), CPT1B(5), CPT1C(7), CPT2(5), CYP27A1(5), CYP4A11(2), CYP4A22(2), CYP7A1(6), CYP8B1(7), EHHADH(7), FABP2(1), FABP3(1), FABP5(1), FABP6(3), FABP7(1), FADS2(5), GK(3), GK2(7), HMGCS2(3), ILK(8), LPL(7), ME1(2), MMP1(2), NR1H3(6), OLR1(2), PCK1(11), PCK2(9), PDPK1(2), PLTP(2), PPARA(4), PPARD(8), PPARG(4), RXRA(6), RXRB(4), RXRG(5), SCD(1), SCP2(5), SLC27A1(4), SLC27A2(6), SLC27A4(10), SLC27A5(5), SLC27A6(8), SORBS1(9), UBC(8), UCP1(2)	28118351	301	100	290	95	105	52	19	63	59	3	0.186	1.000	1.000
289	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	ADAM17(6), APH1A(1), CREBBP(40), CTBP1(3), CTBP2(8), DLL1(15), DLL3(7), DLL4(4), DTX1(14), DTX2(5), DTX3(2), DTX3L(2), DTX4(7), DVL1(7), DVL2(6), DVL3(12), EP300(22), HDAC1(5), HDAC2(2), JAG1(12), JAG2(8), MAML1(5), MAML2(7), MAML3(8), NCOR2(30), NCSTN(7), NOTCH1(26), NOTCH2(25), NOTCH3(22), NOTCH4(16), NUMB(3), NUMBL(4), PSEN1(3), PSEN2(2), PSENEN(2), PTCRA(2), RBPJ(7), RBPJL(6), RFNG(2), SNW1(6)	29602732	371	100	361	154	131	81	14	62	82	1	0.805	1.000	1.000
290	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	41	BCL2(3), CHUK(4), DAXX(10), EGF(10), EGFR(15), ETS1(8), ETS2(4), FOS(1), HOXA7(4), IKBKB(8), JUN(4), MAP2K1(5), MAP2K3(4), MAP2K4(8), MAP2K6(1), MAP3K1(11), MAP3K5(5), MAPK1(3), MAPK13(3), MAPK14(1), MAPK3(1), MAPK8(5), NFKB1(7), NFKBIA(1), PPP2CA(4), PRKCA(5), PRKCD(7), PRKCE(14), PRKCG(17), PRKCH(6), PRKCQ(10), RAF1(10), RELA(5), RIPK1(2), SP1(6), TNF(3), TNFRSF1A(6), TNFRSF1B(3), TRAF2(4)	20786976	228	100	220	80	72	50	7	44	51	4	0.327	1.000	1.000
291	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(45), B3GALT4(7), CDR1(5), DGKI(16), IL6ST(6), PIGK(3), RPL10(5), RPL11(1), RPL12(3), RPL13A(4), RPL14(1), RPL15(1), RPL18(1), RPL19(2), RPL22(2), RPL23(1), RPL24(1), RPL26(1), RPL27(1), RPL28(2), RPL29(1), RPL3(3), RPL31(1), RPL34(2), RPL35A(1), RPL36(1), RPL37(1), RPL38(1), RPL3L(3), RPL4(1), RPL5(3), RPL6(2), RPL7(1), RPL7A(5), RPL8(2), RPL9(3), RPLP0(3), RPLP1(1), RPLP2(2), RPS11(2), RPS13(2), RPS14(2), RPS18(1), RPS20(1), RPS23(1), RPS24(1), RPS25(1), RPS27(1), RPS27A(2), RPS3(2), RPS3A(2), RPS4X(1), RPS4Y1(1), RPS5(4), RPS6(1), RPS6KA1(9), RPS6KA2(9), RPS6KA3(4), RPS6KA6(15), RPS6KB1(5), RPS6KB2(4), RPS7(1), RPS9(1), RPSA(2), SLC36A2(7), TBC1D10C(5), TSPAN9(2), UBA52(2), UBC(8)	22452226	244	100	236	76	60	64	11	49	58	2	0.493	1.000	1.000
292	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	38	AKT1(3), AKT2(8), AKT3(6), BAD(3), BCR(11), BLNK(4), BTK(3), CD19(4), CSK(7), DAG1(13), EPHB2(12), GRB2(4), ITPKA(2), ITPKB(11), LYN(5), MAP2K1(5), MAP2K2(3), MAPK1(3), NFAT5(10), NFKB1(7), NFKB2(7), NFKBIA(1), NFKBIB(6), NFKBIL1(4), PI3(2), PIK3CD(11), PIK3R1(11), PLCG2(15), PPP1R13B(11), RAF1(10), SERPINA4(2), SHC1(7), SOS1(7), SOS2(19), SYK(7), VAV1(9)	21686339	253	100	241	88	82	59	3	50	56	3	0.565	1.000	1.000
293	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(12), ACSS2(10), ACYP1(1), ACYP2(3), ADH1A(4), ADH1B(4), ADH4(2), ADH5(3), ADH6(7), ADH7(1), ADHFE1(9), AKR1A1(1), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH3B1(4), ALDH3B2(7), ALDH9A1(4), ALDOA(1), ALDOB(6), ALDOC(6), BPGM(5), DLAT(3), DLD(4), ENO1(3), ENO2(3), ENO3(4), FBP1(4), FBP2(5), G6PC2(1), GALM(4), GAPDH(2), GAPDHS(4), GCK(4), GPI(5), HK1(16), HK2(10), HK3(6), LDHA(3), LDHAL6B(5), LDHB(4), LDHC(1), PDHA1(1), PDHA2(6), PDHB(4), PFKL(5), PFKM(2), PFKP(14), PGAM2(5), PGAM4(2), PGK1(4), PGK2(3), PGM1(2), PGM3(7), PKLR(7), TPI1(1)	24964559	285	99	271	101	73	83	8	63	57	1	0.471	1.000	1.000
294	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(22), ACACB(35), ACAT1(5), ACAT2(4), ACOT12(5), ACSS1(12), ACSS2(10), ACYP1(1), ACYP2(3), AKR1B1(6), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), DLAT(3), DLD(4), GLO1(2), GRHPR(1), HAGH(3), HAGHL(1), LDHA(3), LDHAL6B(5), LDHB(4), LDHC(1), LDHD(3), MDH1(3), ME1(2), ME2(5), ME3(4), PC(15), PCK1(11), PCK2(9), PDHA1(1), PDHA2(6), PDHB(4), PKLR(7)	20067838	245	99	232	79	71	62	6	49	54	3	0.349	1.000	1.000
295	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	56	ALG2(2), BAK1(4), BAX(6), BFAR(5), BTK(3), CAD(17), CASP10(6), CASP3(2), CD7(5), CSNK1A1(3), DAXX(10), DEDD(2), DEDD2(1), DFFA(4), DIABLO(1), EGFR(15), EPHB2(12), FADD(1), FAF1(8), FAIM2(1), IL1A(2), MAP2K4(8), MAP3K1(11), MAP3K5(5), MAPK1(3), MAPK10(5), MAPK8(5), MAPK8IP1(4), MAPK8IP2(4), MAPK8IP3(13), MAPK9(3), MET(8), NFAT5(10), NFKB1(7), NFKB2(7), NFKBIA(1), NFKBIB(6), NFKBIL1(4), NR0B2(3), PFN2(2), PTPN13(24), RALBP1(8), RIPK1(2), ROCK1(18), SMPD1(6), TPX2(6), TRAF2(4)	30041275	287	99	274	106	80	70	5	51	75	6	0.781	1.000	1.000
296	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	31	ADH1A(4), ADH1B(4), ADH4(2), ADH6(7), ADH7(1), ADHFE1(9), ALDH1A3(6), ALDH3A1(11), ALDH3B1(4), ALDH3B2(7), AOC2(6), AOC3(15), AOX1(12), COMT(4), DBH(6), DCT(13), FAH(8), GOT1(3), GOT2(2), GSTZ1(3), HGD(4), HPD(1), MAOA(2), MAOB(3), PNMT(8), TAT(5), TH(3), TPO(24), TYR(9)	13167243	186	99	168	60	51	37	2	48	44	4	0.447	1.000	1.000
297	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	AGMAT(2), ALDH1A1(7), ALDH1A2(5), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH4A1(4), ALDH9A1(4), AMD1(5), AOC2(6), AOC3(15), ARG1(2), ARG2(2), ASL(6), CKB(2), CKM(1), CKMT1A(3), CKMT1B(1), CKMT2(6), CPS1(22), DAO(11), GAMT(1), GATM(3), GLUD1(2), GOT1(3), GOT2(2), MAOA(2), MAOB(3), NOS1(28), NOS3(10), OAT(2), ODC1(4), OTC(2), P4HA1(5), P4HA2(8), P4HA3(6), P4HB(4), PYCR1(1), RARS(5), SMS(5)	18952255	241	98	223	68	71	59	9	47	54	1	0.0923	1.000	1.000
298	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	35	BTK(3), CALM1(2), CALM2(2), ELK1(3), FCER1A(3), FOS(1), GRB2(4), JUN(4), LYN(5), MAP2K1(5), MAP2K4(8), MAP3K1(11), MAPK1(3), MAPK3(1), MAPK8(5), NFATC1(13), NFATC2(17), NFATC3(4), NFATC4(16), PAK2(7), PIK3R1(11), PLA2G4A(6), PLCG1(19), PPP3CA(10), PPP3CB(6), PPP3CC(5), RAF1(10), SHC1(7), SOS1(7), SYK(7), SYT1(4), VAV1(9)	17251998	218	98	209	53	72	53	7	31	50	5	0.00416	1.000	1.000
299	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(4), ADH1B(4), ADH4(2), ADH6(7), ADH7(1), ADHFE1(9), AGPAT1(3), AGPAT2(2), AGPAT3(4), AGPAT4(5), AKR1A1(1), AKR1B1(6), ALDH1A1(7), ALDH1A2(5), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), CEL(10), DGAT1(3), DGKA(7), DGKB(11), DGKD(6), DGKE(7), DGKG(4), DGKH(10), DGKQ(2), DGKZ(8), GK(3), GLA(3), GLB1(5), LCT(23), LIPC(4), LIPF(5), LIPG(4), LPL(7), PNLIP(4), PNLIPRP1(4), PPAP2A(3), PPAP2B(1), PPAP2C(4)	20656971	243	98	232	89	67	61	7	47	59	2	0.608	1.000	1.000
300	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(3), AKT2(8), AKT3(6), ARHGEF11(18), BCL2(3), CDC42(1), DLG4(3), GNA13(5), LPA(17), MAP2K4(8), MAP3K1(11), MAP3K5(5), MAPK8(5), NFKB1(7), NFKB2(7), NFKBIA(1), NFKBIB(6), NFKBIL1(4), PDK1(3), PHKA2(10), PI3(2), PIK3CB(13), PLD1(19), PLD2(16), PLD3(6), PTK2(11), RDX(7), ROCK1(18), ROCK2(12), SERPINA4(2), SRF(2), TBXA2R(8)	21046269	247	98	233	64	73	58	9	33	68	6	0.0533	1.000	1.000
301	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	63	APAF1(8), BAD(3), BAK1(4), BAX(6), BCL2(3), BCL2L11(1), BID(2), BIRC2(3), BIRC3(6), BIRC5(2), CASP1(4), CASP10(6), CASP2(3), CASP3(2), CASP4(8), CASP6(1), CASP7(3), CASP9(3), CHUK(4), DFFA(4), DFFB(3), FADD(1), FAS(3), FASLG(3), GZMB(3), HELLS(8), IKBKB(8), IRF1(5), IRF3(3), IRF4(7), IRF5(4), IRF6(5), IRF7(1), JUN(4), LTA(4), MAP2K4(8), MAP3K1(11), MAPK10(5), MDM2(5), MYC(5), NFKB1(7), NFKBIA(1), NFKBIB(6), PLEKHG5(7), PRF1(8), RELA(5), RIPK1(2), TNF(3), TNFRSF10B(2), TNFRSF1A(6), TNFRSF1B(3), TNFRSF21(5), TNFRSF25(4), TNFSF10(5), TP73(5), TRADD(2), TRAF1(3), TRAF2(4), TRAF3(4)	23443633	254	97	243	75	64	57	10	47	73	3	0.199	1.000	1.000
302	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(17), CARM1(5), CCND1(1), CREBBP(40), EP300(22), ERCC3(8), ESR1(9), GRIP1(20), GTF2A1(3), GTF2E1(6), GTF2F1(5), HDAC1(5), HDAC2(2), HDAC3(6), HDAC4(25), HDAC5(10), HDAC6(7), MEF2C(4), NCOR2(30), NR0B1(5), NRIP1(17), PELP1(6), POLR2A(19), TBP(3)	19723106	275	97	262	73	92	68	7	45	61	2	0.00825	1.000	1.000
303	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	ANKHD1(12), EEF1A2(5), EEF1B2(3), EEF1D(3), EEF1G(3), EEF2(9), EEF2K(10), EIF1AX(2), EIF1AY(1), EIF2AK1(5), EIF2AK2(5), EIF2AK3(15), EIF2B1(4), EIF2B2(3), EIF2B3(7), EIF2B4(9), EIF2B5(9), EIF2S1(2), EIF2S2(2), EIF4A1(3), EIF4A2(6), EIF4E(2), EIF4EBP1(2), EIF4EBP2(2), EIF4G1(23), EIF4G3(17), EIF5(6), EIF5A(5), EIF5B(20), ETF1(4), GSPT2(6), PABPC1(2), PABPC3(10), PAIP1(1), SLC35A4(6)	18741103	224	96	209	61	57	62	7	49	46	3	0.0921	1.000	1.000
304	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	48	ACHE(11), AGPAT1(3), AGPAT2(2), AGPAT3(4), AGPAT4(5), AGPS(2), CDIPT(1), CDS1(6), CDS2(2), CHAT(4), CHKA(2), CHKB(2), CLC(1), CPT1B(5), DGKA(7), DGKB(11), DGKD(6), DGKE(7), DGKG(4), DGKH(10), DGKQ(2), DGKZ(8), ETNK1(2), GNPAT(1), GPD1(7), GPD2(7), LCAT(4), LYPLA1(1), LYPLA2(2), PAFAH1B1(12), PAFAH2(3), PCYT1A(9), PCYT1B(6), PEMT(1), PISD(5), PLA2G2A(2), PLA2G2E(4), PLA2G3(9), PLA2G4A(6), PLA2G5(1), PLA2G6(6), PLCB2(8), PLCG1(19), PLCG2(15), PPAP2A(3), PPAP2B(1), PPAP2C(4)	21257977	243	95	233	88	77	60	8	45	51	2	0.560	1.000	1.000
305	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	AGXT(1), AGXT2(8), ALAS1(3), ALAS2(12), AMT(4), AOC2(6), AOC3(15), BHMT(5), CBS(6), CHDH(6), CHKA(2), CHKB(2), CPT1B(5), CTH(2), DAO(11), DLD(4), DMGDH(6), GAMT(1), GARS(4), GATM(3), GCAT(4), GLDC(8), MAOA(2), MAOB(3), PEMT(1), PISD(5), PLCB2(8), PLCG1(19), PLCG2(15), PSPH(2), SARDH(13), SARS(8), SHMT1(2), SHMT2(9), TARS(7)	18004346	212	95	200	69	61	46	10	44	50	1	0.440	1.000	1.000
306	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(19), CALM1(2), CALM2(2), CREB1(3), ELK1(3), FOS(1), GNAI1(1), GNAQ(4), GNAS(29), GNB1(1), GNGT1(3), JUN(4), MAP2K1(5), MAPK3(1), NFATC1(13), NFATC2(17), NFATC3(4), NFATC4(16), PLCG1(19), PPP3CA(10), PPP3CB(6), PPP3CC(5), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), PRKCA(5), RAF1(10), RPS6KA3(4), SYT1(4)	15033057	222	95	211	67	89	52	4	33	44	0	0.0511	1.000	1.000
307	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	69	ADH1A(4), ADH1B(4), ADH4(2), ADH5(3), ADH6(7), ADH7(1), ADHFE1(9), AKR1C1(3), AKR1C2(1), AKR1C3(2), AKR1C4(6), ALDH1A3(6), ALDH3A1(11), ALDH3B1(4), ALDH3B2(7), CYP1A1(5), CYP1A2(5), CYP1B1(2), CYP2B6(6), CYP2C18(4), CYP2C19(7), CYP2C8(1), CYP2E1(6), CYP2F1(4), CYP2S1(6), CYP3A4(4), CYP3A43(4), CYP3A7(4), DHDH(5), EPHX1(9), GSTA1(3), GSTA2(2), GSTA3(1), GSTA4(2), GSTA5(2), GSTK1(1), GSTM2(1), GSTM3(2), GSTM4(3), GSTM5(2), GSTO2(3), GSTP1(1), GSTZ1(3), MGST1(3), MGST2(3), MGST3(3), UGT1A1(4), UGT1A10(1), UGT1A3(1), UGT1A4(3), UGT1A5(3), UGT1A6(6), UGT1A7(3), UGT1A9(3), UGT2A1(3), UGT2A3(6), UGT2B10(5), UGT2B11(1), UGT2B15(3), UGT2B17(2), UGT2B28(7), UGT2B4(4), UGT2B7(6)	24504533	238	95	228	66	54	64	3	60	56	1	0.112	1.000	1.000
308	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	33	ACTA1(3), CRKL(1), DOCK1(17), ELK1(3), FOS(1), GAB1(3), GRB2(4), HGF(15), ITGA1(8), ITGB1(10), JUN(4), MAP2K1(5), MAP2K2(3), MAP4K1(4), MAPK1(3), MAPK3(1), MAPK8(5), MET(8), PAK1(5), PIK3R1(11), PTK2(11), PTK2B(16), PTPN11(6), PXN(4), RAF1(10), RAP1A(2), RAP1B(6), RASA1(17), SOS1(7), SRC(3), STAT3(7)	17658832	203	95	191	64	51	45	9	46	49	3	0.271	1.000	1.000
309	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1A(16), ADRA1B(5), ADRA1D(4), ADRA2A(7), ADRA2C(5), ADRB1(7), ADRB2(8), ADRB3(5), CHRM1(4), CHRM2(17), CHRM3(11), CHRM4(2), CHRM5(2), DRD1(3), DRD2(9), DRD3(7), DRD4(3), DRD5(10), HRH1(5), HRH2(8), HTR1A(11), HTR1B(10), HTR1D(4), HTR1E(10), HTR1F(8), HTR2A(6), HTR2B(5), HTR2C(6), HTR4(5), HTR5A(9), HTR6(7), HTR7(10)	11062835	229	95	222	81	89	50	13	50	27	0	0.116	1.000	1.000
310	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	24	ATM(38), BMPR1B(7), CCND2(3), DMC1(8), EGR1(10), ESR2(9), GJA4(4), INHA(5), LHCGR(11), MLH1(6), MSH5(4), NCOR1(26), NR5A1(5), NRIP1(17), PGR(14), PRLR(4), PTGER2(5), SMPD1(6), VDR(2), ZP2(8)	14401287	192	95	179	55	45	55	8	32	48	4	0.151	1.000	1.000
311	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	112	ATP12A(18), ATP4A(17), ATP4B(4), ATP5A1(2), ATP5B(7), ATP5C1(3), ATP5F1(1), ATP5G2(1), ATP5G3(1), ATP5J(1), ATP5J2(1), ATP5L(2), ATP6AP1(6), ATP6V0A1(5), ATP6V0A2(7), ATP6V0A4(10), ATP6V0B(4), ATP6V0D1(8), ATP6V0D2(2), ATP6V1A(6), ATP6V1B2(5), ATP6V1C1(2), ATP6V1C2(12), ATP6V1D(3), ATP6V1E1(2), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(7), COX10(2), COX15(6), COX4I1(6), COX4I2(1), COX6B1(2), COX7A1(1), COX7A2(1), COX7B(2), COX7C(1), COX8C(4), CYC1(3), LHPP(4), NDUFA1(1), NDUFA10(4), NDUFA12(2), NDUFA3(1), NDUFA6(1), NDUFA8(5), NDUFA9(4), NDUFAB1(2), NDUFB11(2), NDUFB2(1), NDUFB3(2), NDUFB4(1), NDUFB5(1), NDUFB6(1), NDUFB7(1), NDUFB8(1), NDUFB9(2), NDUFC2(1), NDUFS1(7), NDUFS2(5), NDUFS3(2), NDUFS4(2), NDUFS5(3), NDUFS6(3), NDUFS7(3), NDUFS8(2), NDUFV1(5), PPA1(2), PPA2(3), SDHA(6), SDHB(4), SDHC(1), SDHD(1), TCIRG1(7), UQCRB(1), UQCRC1(2), UQCRC2(3), UQCRFS1(1), UQCRQ(1)	23452838	272	94	263	98	87	67	11	51	56	0	0.595	1.000	1.000
312	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	22	IMPA1(4), INPP1(1), INPP4A(6), INPP4B(7), INPP5A(8), INPPL1(24), ITPKA(2), ITPKB(11), MIOX(5), OCRL(9), PIK3C2A(14), PIK3C2B(19), PIK3C2G(10), PIK3CB(13), PIK3CG(21), PLCB1(19), PLCB2(8), PLCB3(12), PLCB4(13), PLCD1(4), PLCG1(19), PLCG2(15)	18252148	244	94	226	71	73	56	10	48	55	2	0.246	1.000	1.000
313	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	30	AKR1C3(2), ALOX12(6), ALOX15(7), ALOX5(10), CBR1(1), CBR3(2), CYP4F2(6), CYP4F3(11), EPX(9), GGT1(6), LPO(9), LTA4H(5), MPO(7), PLA2G2A(2), PLA2G2E(4), PLA2G3(9), PLA2G4A(6), PLA2G5(1), PLA2G6(6), PRDX1(1), PRDX2(2), PRDX5(1), PRDX6(2), PTGDS(1), PTGES2(3), PTGIS(6), PTGS1(12), PTGS2(7), TBXAS1(6), TPO(24)	11835282	174	94	170	48	62	29	9	42	31	1	0.0527	1.000	1.000
314	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	46	APAF1(8), BAD(3), BAX(6), BCL2(3), BCL2L2(4), BOK(1), CASP1(4), CASP10(6), CASP2(3), CASP3(2), CASP4(8), CASP6(1), CASP7(3), CASP9(3), CD40(3), CD40LG(5), CRADD(1), DAXX(10), DFFA(4), DFFB(3), FADD(1), FAS(3), FASLG(3), IKBKE(12), LTA(4), MCL1(1), NFKB1(7), NFKBIA(1), NGFR(4), NR3C1(6), NTRK1(10), PTPN13(24), RIPK1(2), TFG(1), TNF(3), TNFRSF1A(6), TNFRSF1B(3), TRADD(2), TRAF1(3), TRAF2(4), TRAF3(4), TRAF6(6)	18099189	191	93	180	62	44	40	10	45	50	2	0.451	1.000	1.000
315	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(3), AGTR2(4), CALM1(2), CALM2(2), CAMK2A(3), CAMK2B(4), CAMK2D(3), CAMK2G(8), CDK5(2), F2(9), FYN(10), GNA11(6), GNAI1(1), GNB1(1), GNGT1(3), GRB2(4), JAK2(13), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK14(1), MAPK3(1), MAPK8(5), MAPT(7), MYLK(22), PLCG1(19), PRKCA(5), PTK2B(16), RAF1(10), SHC1(7), SOS1(7), STAT1(10), STAT3(7), STAT5A(3), SYT1(4)	17859302	213	93	209	73	69	56	7	41	37	3	0.306	1.000	1.000
316	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(7), F11(4), F12(3), F13B(16), F2(9), F5(21), F7(10), F8(22), F9(9), FGA(9), FGB(4), FGG(3), LPA(17), PLAT(7), PLG(14), SERPINB2(7), SERPINE1(3), SERPINF2(8), VWF(28)	15158900	201	93	197	51	51	44	9	56	40	1	0.0328	1.000	1.000
317	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(3), ALDH4A1(4), ALDH5A1(6), CAD(17), CPS1(22), EARS2(3), EPRS(11), GAD1(7), GAD2(9), GCLC(3), GCLM(3), GFPT1(4), GFPT2(5), GLS(10), GLS2(7), GLUD1(2), GLUD2(11), GLUL(5), GMPS(7), GNPNAT1(4), GOT1(3), GOT2(2), GPT(3), GPT2(5), GSR(5), GSS(3), NADSYN1(8), NAGK(2), PPAT(5), QARS(5)	16949877	184	93	181	67	48	49	7	41	39	0	0.574	1.000	1.000
318	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	ADAM17(6), APC(43), AXIN1(9), BTRC(9), CTNNB1(22), DLL1(15), DVL1(7), FZD1(10), GSK3B(5), NOTCH1(26), PSEN1(3), WNT1(8)	9169493	163	93	149	52	47	28	6	26	47	9	0.422	1.000	1.000
319	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(4), BTK(3), CALM1(2), CALM2(2), CD79A(6), CD79B(2), ELK1(3), FOS(1), GRB2(4), JUN(4), LYN(5), MAP2K1(5), MAP3K1(11), MAPK14(1), MAPK3(1), MAPK8(5), NFATC1(13), NFATC2(17), NFATC3(4), NFATC4(16), PLCG1(19), PPP3CA(10), PPP3CB(6), PPP3CC(5), PRKCA(5), RAF1(10), SHC1(7), SOS1(7), SYK(7), SYT1(4), VAV1(9)	16430692	198	92	190	56	75	48	5	30	38	2	0.0322	1.000	1.000
320	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2A1(3), GTF2A1L(3), GTF2B(4), GTF2E1(6), GTF2E2(2), GTF2F1(5), GTF2F2(2), GTF2H1(2), GTF2H3(2), GTF2H4(7), GTF2I(4), GTF2IRD1(13), STON1(6), TAF1(20), TAF10(1), TAF13(1), TAF1L(29), TAF2(11), TAF4(12), TAF4B(3), TAF5(2), TAF5L(6), TAF6(12), TAF6L(5), TAF7(7), TAF7L(8), TAF9B(4), TBPL1(2), TBPL2(6)	15449868	188	92	181	48	48	44	8	37	51	0	0.0820	1.000	1.000
321	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(2), ACTR3(2), ARHGAP1(4), ARHGAP4(4), ARHGAP5(18), ARHGAP6(9), ARHGEF1(11), ARHGEF11(18), ARHGEF5(5), ARPC1A(3), ARPC2(3), ARPC4(2), BAIAP2(5), CFL1(1), DIAPH1(11), GSN(11), LIMK1(5), MYL2(8), MYLK(22), OPHN1(9), PIP5K1A(4), PIP5K1B(1), PPP1R12B(15), ROCK1(18), SRC(3), TLN1(23), VCL(6)	19475904	223	92	211	71	64	55	10	35	55	4	0.339	1.000	1.000
322	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(10), AKT1(3), AKT2(8), AKT3(6), DAG1(13), GNAQ(4), ITPKA(2), ITPKB(11), ITPR1(24), ITPR2(30), ITPR3(36), NFKB1(7), NFKB2(7), NFKBIA(1), NFKBIB(6), NFKBIL1(4), PDK1(3), PHKA2(10), PIK3CB(13), PITX2(6), PLD1(19), PLD2(16), PLD3(6), VN1R1(3)	19243480	248	92	240	65	86	56	12	44	47	3	0.0182	1.000	1.000
323	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	36	AKT1(3), ATF2(3), CDC42(1), DLD(4), DUSP10(8), DUSP4(1), DUSP8(1), GAB1(3), GCK(4), IL1R1(4), JUN(4), MAP2K4(8), MAP2K5(1), MAP3K1(11), MAP3K10(8), MAP3K11(7), MAP3K12(15), MAP3K13(9), MAP3K2(4), MAP3K3(8), MAP3K4(21), MAP3K5(5), MAP3K7(10), MAP3K9(3), MAPK10(5), MAPK7(6), MAPK8(5), MAPK9(3), MYEF2(9), NFATC3(4), NR2C2(3), PAPPA(25), SHC1(7), TRAF6(6), ZAK(9)	20962605	228	92	223	74	60	61	14	39	51	3	0.345	1.000	1.000
324	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	26	ARHGDIB(1), CASP10(6), CASP3(2), CASP6(1), CASP7(3), CFLAR(1), DAXX(10), DFFA(4), DFFB(3), FADD(1), FAF1(8), JUN(4), LMNA(6), LMNB1(4), LMNB2(6), MAP2K4(8), MAP3K1(11), MAP3K7(10), MAPK8(5), PAK1(5), PAK2(7), PRKDC(40), PTPN13(24), RB1(13), RIPK2(1), SPTAN1(21)	16909222	205	91	200	61	46	60	9	33	54	3	0.202	1.000	1.000
325	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	20	ATM(38), ATR(18), BRCA1(17), CCNB1(3), CDC25A(6), CDC25B(4), CDC34(2), CDKN1A(3), CDKN2D(3), CHEK1(4), CHEK2(8), EP300(22), MDM2(5), MYT1(19), PRKDC(40), RPS6KA1(9), WEE1(4), YWHAH(3), YWHAQ(2)	17173734	210	91	201	64	55	56	5	42	48	4	0.385	1.000	1.000
326	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CALM1(2), CALM2(2), CAMK1(3), CAMK1G(6), ELK1(3), FPR1(6), GNA15(3), GNB1(1), GNGT1(3), MAP2K1(5), MAP2K2(3), MAP2K3(4), MAP2K6(1), MAP3K1(11), MAPK1(3), MAPK14(1), MAPK3(1), NCF1(3), NCF2(4), NFATC1(13), NFATC2(17), NFATC3(4), NFATC4(16), NFKB1(7), NFKBIA(1), PAK1(5), PIK3C2G(10), PLCB1(19), PPP3CA(10), PPP3CB(6), PPP3CC(5), RAF1(10), RELA(5), SYT1(4)	16399444	197	90	187	65	67	44	4	34	48	0	0.280	1.000	1.000
327	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ACYP2(3), ADH1A(4), ADH1B(4), ADH4(2), ADH6(7), ADH7(1), ADHFE1(9), AKR1A1(1), ALDH1A1(7), ALDH1A2(5), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH3B1(4), ALDH3B2(7), ALDH9A1(4), ALDOA(1), ALDOB(6), ALDOC(6), BPGM(5), DLAT(3), DLD(4), ENO1(3), ENO2(3), ENO3(4), FBP1(4), FBP2(5), GAPDH(2), GCK(4), GPI(5), HK1(16), HK2(10), HK3(6), LDHA(3), LDHB(4), LDHC(1), PDHA1(1), PDHA2(6), PDHB(4), PFKM(2), PFKP(14), PGK1(4), PGM1(2), PGM3(7), PKLR(7), TPI1(1)	20976024	243	90	230	87	60	66	6	56	54	1	0.618	1.000	1.000
328	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ACYP2(3), ADH1A(4), ADH1B(4), ADH4(2), ADH6(7), ADH7(1), ADHFE1(9), AKR1A1(1), ALDH1A1(7), ALDH1A2(5), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH3B1(4), ALDH3B2(7), ALDH9A1(4), ALDOA(1), ALDOB(6), ALDOC(6), BPGM(5), DLAT(3), DLD(4), ENO1(3), ENO2(3), ENO3(4), FBP1(4), FBP2(5), GAPDH(2), GCK(4), GPI(5), HK1(16), HK2(10), HK3(6), LDHA(3), LDHB(4), LDHC(1), PDHA1(1), PDHA2(6), PDHB(4), PFKM(2), PFKP(14), PGK1(4), PGM1(2), PGM3(7), PKLR(7), TPI1(1)	20976024	243	90	230	87	60	66	6	56	54	1	0.618	1.000	1.000
329	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(7), CALCR(6), CALCRL(8), CD97(4), CRHR1(11), CRHR2(4), ELTD1(17), EMR1(13), EMR2(9), GHRHR(4), GIPR(4), GLP1R(1), GLP2R(8), GPR64(13), LPHN1(19), LPHN2(19), LPHN3(17), SCTR(3), VIPR1(3), VIPR2(3)	11421754	173	90	168	50	43	43	6	50	30	1	0.0573	1.000	1.000
330	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	27	ARHGDIB(1), BAG4(2), CASP2(3), CASP3(2), CRADD(1), DFFA(4), DFFB(3), FADD(1), JUN(4), LMNA(6), LMNB1(4), LMNB2(6), MADD(16), MAP2K4(8), MAP3K1(11), MAP3K7(10), MAPK8(5), PAK1(5), PAK2(7), PRKDC(40), RB1(13), RIPK1(2), SPTAN1(21), TNF(3), TNFRSF1A(6), TRADD(2), TRAF2(4)	16108101	190	90	187	62	52	50	10	28	46	4	0.393	1.000	1.000
331	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(8), CDC7(4), CDK2(3), CDT1(4), DIAPH2(7), GMNN(1), MCM10(10), MCM2(14), MCM3(6), MCM4(13), MCM5(8), MCM6(8), MCM7(7), NACA(3), PCNA(2), POLA2(4), POLD1(15), POLD2(4), POLD3(7), POLE(24), POLE2(4), PRIM1(2), RFC1(10), RFC2(1), RFC3(3), RFC4(1), RFC5(1), RPA1(2), RPA2(2), RPA3(2), RPA4(5), RPS27A(2), UBA52(2), UBC(8)	21753848	197	89	191	52	69	36	7	33	50	2	0.0923	1.000	1.000
332	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(3), ACAA1(3), ACAA2(5), ACADM(4), ACADS(4), ACAT1(5), ACAT2(4), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH6A1(6), ALDH9A1(4), AOX1(12), AUH(7), BCAT1(5), BCAT2(6), BCKDHA(11), BCKDHB(3), DBT(4), DLD(4), EHHADH(7), HADH(3), HADHA(4), HADHB(5), HIBADH(3), HMGCS1(2), HMGCS2(3), HSD17B4(7), IVD(4), MCCC1(3), MCCC2(3), MCEE(4), MUT(6), OXCT1(8), OXCT2(3), PCCA(8), PCCB(5)	18452974	209	89	193	68	45	55	4	37	65	3	0.589	1.000	1.000
333	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(9), AADAC(5), ABAT(3), ACADS(4), ACAT1(5), ACAT2(4), ACSM1(5), AKR1B10(6), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH5A1(6), ALDH9A1(4), BDH1(5), DDHD1(9), EHHADH(7), GAD1(7), GAD2(9), HADH(3), HADHA(4), HMGCS1(2), HMGCS2(3), HSD17B4(7), HSD3B7(6), ILVBL(5), L2HGDH(2), OXCT1(8), OXCT2(3), PDHA1(1), PDHA2(6), PDHB(4), PLA1A(2), PPME1(1), PRDX6(2), RDH11(1), RDH12(3), RDH13(5)	17394750	197	89	186	76	58	43	4	38	53	1	0.786	1.000	1.000
334	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	68	CALR(5), CANX(3), CD74(1), CD8A(4), CD8B(1), CIITA(17), CREB1(3), CTSB(3), CTSS(2), HLA-C(6), HLA-DMA(1), HLA-DMB(3), HLA-DOA(2), HLA-DOB(2), HLA-DPA1(2), HLA-DPB1(3), HLA-DQA1(1), HLA-DQA2(3), HLA-DQB1(1), HLA-DRA(8), HLA-E(5), HLA-F(7), HLA-G(5), HSP90AA1(11), HSP90AB1(6), HSPA5(2), IFI30(2), IFNA1(1), IFNA10(4), IFNA13(1), IFNA16(4), IFNA2(1), IFNA4(1), IFNA5(2), IFNA6(3), IFNA7(4), IFNA8(1), KIR2DL3(3), KIR3DL1(5), KIR3DL2(2), KLRC1(3), KLRC3(2), KLRD1(3), LGMN(6), LTA(4), NFYA(1), NFYC(2), PDIA3(3), PSME1(3), PSME2(1), RFX5(11), RFXANK(4), RFXAP(1), TAP1(4), TAP2(6), TAPBP(6)	18672597	201	89	199	53	35	58	15	46	45	2	0.0484	1.000	1.000
335	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(12), ADRBK2(5), ARRB2(1), CALM1(2), CALM2(2), CALML3(1), CAMK2A(3), CAMK2B(4), CAMK2D(3), CAMK2G(8), CLCA1(10), CLCA2(6), CLCA4(12), CNGA3(8), CNGA4(19), CNGB1(15), GNAL(2), GUCA1A(3), GUCA1B(2), GUCA1C(4), PDC(2), PDE1C(11), PRKACA(4), PRKACB(4), PRKACG(8), PRKG1(10), PRKG2(13), PRKX(5)	13099384	179	89	171	55	55	36	5	39	43	1	0.174	1.000	1.000
336	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(4), ARG1(2), ARG2(2), ASL(6), ASS1(9), CKB(2), CKM(1), CKMT1A(3), CKMT1B(1), CKMT2(6), CPS1(22), DAO(11), EPRS(11), GAMT(1), GATM(3), GLUD1(2), GLUD2(11), GOT1(3), GOT2(2), LAP3(2), NOS1(28), NOS3(10), OAT(2), OTC(2), P4HA1(5), P4HA2(8), P4HA3(6), PYCR1(1), PYCR2(3), PYCRL(2), RARS(5), RARS2(6)	15394352	182	88	178	52	59	45	10	41	27	0	0.0719	1.000	1.000
337	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(1), ACTG2(9), ADCY3(12), ADCY9(13), AK1(1), ARF1(5), ARF4(1), ARF5(1), ARL4D(1), ATP6V0A1(5), ATP6V0A2(7), ATP6V0A4(10), ATP6V0B(4), ATP6V0D1(8), ATP6V0D2(2), ATP6V1A(6), ATP6V1C1(2), ATP6V1C2(12), ATP6V1D(3), ATP6V1E1(2), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(7), ERO1L(1), GNAS(29), PDIA4(3), PLCG1(19), PLCG2(15), PRKCA(5), SEC61A1(5), SEC61A2(1), SEC61B(1), SEC61G(1), TRIM23(5)	15886250	202	88	192	67	78	37	6	39	42	0	0.386	1.000	1.000
338	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	21	ARHGAP5(18), DIAPH1(11), FYN(10), GSN(11), ITGA1(8), ITGB1(10), MAP2K1(5), MAPK1(3), MAPK3(1), MYL2(8), MYLK(22), PIK3R1(11), PTK2(11), PXN(4), RAF1(10), ROCK1(18), SHC1(7), SRC(3), TLN1(23)	15078096	194	87	181	47	52	46	8	37	46	5	0.0255	1.000	1.000
339	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	25	CSNK2A1(5), EGF(10), EGFR(15), ELK1(3), FOS(1), GRB2(4), JAK1(12), JUN(4), MAP2K1(5), MAP2K4(8), MAP3K1(11), MAPK3(1), MAPK8(5), PIK3R1(11), PLCG1(19), PRKCA(5), RAF1(10), RASA1(17), SHC1(7), SOS1(7), SRF(2), STAT1(10), STAT3(7), STAT5A(3)	15164766	182	87	173	50	49	46	5	27	52	3	0.0928	1.000	1.000
340	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(6), AKR1D1(3), ARSD(4), ARSE(5), CARM1(5), CYP11B1(12), CYP11B2(5), CYP19A1(13), HEMK1(1), HSD11B1(3), HSD11B2(3), HSD17B1(4), HSD17B12(3), HSD17B2(2), HSD17B3(1), HSD17B7(3), HSD3B1(4), HSD3B2(1), LCMT1(1), LCMT2(11), METTL6(3), PRMT2(8), PRMT3(5), PRMT5(3), PRMT6(4), PRMT7(6), PRMT8(9), SRD5A1(3), STS(6), SULT1E1(2), SULT2A1(3), UGT1A1(4), UGT1A10(1), UGT1A3(1), UGT1A4(3), UGT1A5(3), UGT1A6(6), UGT1A7(3), UGT1A9(3), UGT2A1(3), UGT2A3(6), UGT2B10(5), UGT2B11(1), UGT2B15(3), UGT2B17(2), UGT2B28(7), UGT2B4(4), UGT2B7(6), WBSCR22(6)	21453585	209	87	202	67	50	68	9	36	45	1	0.200	1.000	1.000
341	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(6), AARS2(10), CARS(5), CARS2(6), DARS(2), DARS2(3), EARS2(3), EPRS(11), FARS2(7), FARSA(3), FARSB(1), GARS(4), HARS(9), HARS2(4), IARS(10), IARS2(9), KARS(5), LARS(5), LARS2(8), MARS(4), MARS2(2), MTFMT(1), NARS(5), QARS(5), RARS(5), RARS2(6), SARS(8), SARS2(7), TARS(7), TARS2(7), VARS(16), VARS2(12), WARS(5), WARS2(10), YARS(6), YARS2(2)	23293919	219	87	215	65	69	58	9	40	43	0	0.175	1.000	1.000
342	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(6), ARSB(2), FUCA1(1), FUCA2(2), GALNS(1), GBA(9), GLB1(5), GNS(5), GUSB(11), HEXA(2), HEXB(3), HGSNAT(5), HPSE(8), HPSE2(5), HYAL1(6), HYAL2(5), IDS(4), IDUA(4), LCT(23), MAN2B1(17), MAN2B2(18), MAN2C1(11), MANBA(7), NAGLU(6), NEU1(3), NEU2(6), NEU3(5), NEU4(2), SPAM1(9)	14764926	191	87	187	59	59	52	8	31	40	1	0.190	1.000	1.000
343	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	25	CSNK2A1(5), ELK1(3), FOS(1), GRB2(4), JAK1(12), JUN(4), MAP2K1(5), MAP2K4(8), MAP3K1(11), MAPK3(1), MAPK8(5), PDGFA(2), PDGFRA(11), PIK3R1(11), PLCG1(19), PRKCA(5), RAF1(10), RASA1(17), SHC1(7), SOS1(7), SRF(2), STAT1(10), STAT3(7), STAT5A(3)	14061063	170	87	162	42	43	47	4	25	48	3	0.0301	1.000	1.000
344	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	24	ARNT(6), EIF1(1), EIF2B1(4), EIF2B2(3), EIF2B3(7), EIF2B4(9), EIF2B5(9), EIF2S1(2), EIF2S2(2), ELAVL1(9), FLT1(16), FLT4(24), HIF1A(7), KDR(13), NOS3(10), PIK3R1(11), PLCG1(19), PRKCA(5), PTK2(11), PXN(4), SHC1(7), VHL(2)	13639951	181	87	174	45	55	44	8	31	42	1	0.0234	1.000	1.000
345	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	50	AKR1C3(2), ALOX12(6), ALOX12B(10), ALOX15(7), ALOX15B(3), ALOX5(10), CBR1(1), CBR3(2), CYP2B6(6), CYP2C18(4), CYP2C19(7), CYP2C8(1), CYP2E1(6), CYP2J2(3), CYP2U1(6), CYP4A11(2), CYP4A22(2), CYP4F2(6), CYP4F3(11), DHRS4(1), EPHX2(4), GGT1(6), GPX2(3), GPX3(1), GPX5(2), GPX6(5), GPX7(3), LTA4H(5), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G2A(2), PLA2G2D(1), PLA2G2E(4), PLA2G3(9), PLA2G4A(6), PLA2G5(1), PLA2G6(6), PTGDS(1), PTGES2(3), PTGIS(6), PTGS1(12), PTGS2(7), TBXAS1(6)	16563665	194	86	190	47	68	44	5	43	34	0	0.00361	1.000	1.000
346	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	ARNTL(8), AZIN1(2), CBX3(1), CLDN5(2), CLOCK(5), CRY1(3), CRY2(5), DAZAP2(4), DNAJA1(6), EIF4G2(7), ETV6(7), G0S2(2), GFRA1(9), GSTM3(2), GSTP1(1), HERPUD1(2), HSPA8(4), IDI1(2), KLF9(2), MYF6(5), NCKAP1(9), NCOA4(5), NR1D2(6), PER1(4), PER2(15), PIGF(1), PPP1R3C(4), PPP2CB(3), PSMA4(4), PURA(1), SF3A3(3), SUMO3(3), TOB1(1), TUBB3(7), UCP3(3), UGP2(7), VAPA(3), ZFR(13)	15664745	171	85	167	53	45	40	6	36	43	1	0.390	1.000	1.000
347	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(3), ALDH4A1(4), ALDH5A1(6), CAD(17), CPS1(22), EPRS(11), GAD1(7), GAD2(9), GCLC(3), GCLM(3), GFPT1(4), GLS(10), GLS2(7), GLUD1(2), GLUL(5), GMPS(7), GOT1(3), GOT2(2), GPT(3), GPT2(5), GSS(3), NADSYN1(8), PPAT(5), QARS(5)	14245065	154	85	153	53	41	43	5	32	33	0	0.476	1.000	1.000
348	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(3), ACAA2(5), ACADL(2), ACADM(4), ACADS(4), ACADSB(7), ACADVL(1), ACAT1(5), ACAT2(4), ACOX1(5), ACOX3(11), ACSL1(3), ACSL3(8), ACSL4(4), ACSL5(7), ACSL6(6), ADH1A(4), ADH1B(4), ADH4(2), ADH5(3), ADH6(7), ADH7(1), ADHFE1(9), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), CPT1A(10), CPT1B(5), CPT1C(7), CPT2(5), CYP4A11(2), CYP4A22(2), EHHADH(7), GCDH(8), HADH(3), HADHA(4), HADHB(5), HSD17B4(7)	21011347	219	85	204	58	47	59	7	42	62	2	0.0409	1.000	1.000
349	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(6), AARS2(10), ABAT(3), ACY3(1), ADSL(5), ADSS(5), ADSSL1(8), AGXT(1), AGXT2(8), ASL(6), ASNS(4), ASPA(1), ASRGL1(2), ASS1(9), CAD(17), CRAT(5), DARS(2), DARS2(3), DDO(6), DLAT(3), DLD(4), GAD1(7), GAD2(9), GOT1(3), GOT2(2), GPT(3), GPT2(5), NARS(5), PC(15), PDHA1(1), PDHA2(6), PDHB(4)	16218924	169	85	166	66	57	43	1	31	37	0	0.752	1.000	1.000
350	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	24	APC(43), ASAH1(4), CAMP(2), CASP3(2), CERK(6), CREB1(3), CREB5(5), CXCL2(2), DAG1(13), EPHB2(12), FOS(1), GNAQ(4), ITPKA(2), ITPKB(11), JUN(4), MAP2K4(8), MAPK1(3), MAPK10(5), MAPK8(5), MAPK8IP1(4), MAPK8IP2(4), MAPK8IP3(13), MAPK9(3)	11948394	159	85	155	42	43	38	3	26	39	10	0.0643	1.000	1.000
351	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CD14(2), CHUK(4), ELK1(3), FOS(1), IKBKB(8), IRAK1(6), JUN(4), LY96(4), MAP2K3(4), MAP2K4(8), MAP2K6(1), MAP3K1(11), MAP3K7(10), MAPK14(1), MAPK8(5), MYD88(2), NFKB1(7), NFKBIA(1), PPARA(4), RELA(5), TIRAP(1), TLR10(7), TLR2(2), TLR3(6), TLR4(21), TLR6(3), TLR7(5), TLR9(15), TOLLIP(5), TRAF6(6)	15655244	162	85	155	53	42	34	7	37	40	2	0.376	1.000	1.000
352	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOA(1), ALDOB(6), ALDOC(6), DLAT(3), DLD(4), ENO1(3), ENO2(3), ENO3(4), FBP1(4), FBP2(5), GAPDH(2), GAPDHS(4), GCK(4), GOT1(3), GOT2(2), GPI(5), HK1(16), HK2(10), HK3(6), LDHA(3), LDHAL6B(5), LDHB(4), LDHC(1), MDH1(3), PC(15), PCK1(11), PDHA1(1), PDHA2(6), PDHB(4), PDHX(5), PFKL(5), PFKM(2), PFKP(14), PGAM2(5), PGK1(4), PGK2(3), PKLR(7), TNFAIP1(4), TPI1(1)	18230069	194	84	188	81	64	55	3	38	33	1	0.825	1.000	1.000
353	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	26	ALDH1A3(6), ALDH3A1(11), ALDH3B1(4), ALDH3B2(7), AOC2(6), AOC3(15), EPX(9), ESCO1(7), ESCO2(8), GOT1(3), GOT2(2), HPD(1), LPO(9), MAOA(2), MAOB(3), MIF(1), MPO(7), NAT6(3), PNPLA3(2), PRDX6(2), SH3GLB1(3), TAT(5), TPO(24)	14248371	140	84	127	41	40	22	3	36	37	2	0.536	1.000	1.000
354	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	21	ARFIP2(3), CDK5(2), CDK5R1(4), CFL1(1), CHN1(3), LIMK1(5), MAP3K1(11), MYL2(8), MYLK(22), NCF2(4), PAK1(5), PDGFRA(11), PIK3R1(11), PLD1(19), PPP1R12B(15), RALBP1(8), RPS6KB1(5), TRIO(39), VAV1(9), WASF1(5)	14051946	190	84	186	61	54	53	2	37	41	3	0.454	1.000	1.000
355	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	ATF2(3), BCR(11), BLNK(4), ELK1(3), FOS(1), GRB2(4), JUN(4), LYN(5), MAP2K1(5), MAP3K1(11), MAPK1(3), MAPK3(1), MAPK8IP3(13), PAPPA(25), RPS6KA1(9), RPS6KA3(4), SHC1(7), SOS1(7), SYK(7), VAV1(9), VAV2(12), VAV3(10)	13738984	158	84	153	62	51	44	3	32	27	1	0.640	1.000	1.000
356	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(3), ACTN1(7), ACTN2(23), CAPN1(5), CAPNS1(2), CAPNS2(2), ITGA1(8), ITGB1(10), ITGB3(7), PTK2(11), PXN(4), SPTAN1(21), SRC(3), TLN1(23)	12238790	129	84	124	56	55	27	7	22	18	0	0.784	1.000	1.000
357	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	20	ADCY1(19), CD3E(2), CD3G(1), CREBBP(40), CSK(7), GNAS(29), GNB1(1), GNGT1(3), HLA-DRA(8), LCK(4), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), PTPRC(19), ZAP70(14)	9488059	178	83	170	64	68	47	2	26	35	0	0.474	1.000	1.000
358	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	20	ADCY1(19), CD3E(2), CD3G(1), CREBBP(40), CSK(7), GNAS(29), GNB1(1), GNGT1(3), HLA-DRA(8), LCK(4), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), PTPRC(19), ZAP70(14)	9488059	178	83	170	64	68	47	2	26	35	0	0.474	1.000	1.000
359	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	40	ACY3(1), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH3B1(4), ALDH3B2(7), ALDH9A1(4), AOC2(6), AOC3(15), ASPA(1), CARM1(5), CNDP1(6), FTCD(5), HAL(4), HARS(9), HARS2(4), HDC(8), HEMK1(1), HNMT(2), LCMT1(1), LCMT2(11), MAOA(2), MAOB(3), METTL6(3), PRMT2(8), PRMT3(5), PRMT5(3), PRMT6(4), PRMT7(6), PRMT8(9), PRPS1(3), PRPS2(3), UROC1(10), WBSCR22(6)	16550436	200	83	180	56	52	45	7	37	55	4	0.182	1.000	1.000
360	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM1(2), CALM2(2), DLG4(3), GRIN1(8), GRIN2A(16), GRIN2B(23), GRIN2C(6), GRIN2D(7), NOS1(28), PPP3CA(10), PPP3CB(6), PPP3CC(5), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), PRKCA(5), SYT1(4)	10962140	156	83	152	59	55	35	5	30	31	0	0.491	1.000	1.000
361	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(22), ACAT1(5), ACAT2(4), ACYP1(1), ACYP2(3), ADH5(3), AKR1B1(6), ALDH1A1(7), ALDH1A2(5), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), DLAT(3), DLD(4), GLO1(2), GRHPR(1), HAGH(3), HAGHL(1), LDHA(3), LDHB(4), LDHC(1), LDHD(3), MDH1(3), ME1(2), ME2(5), ME3(4), PC(15), PCK1(11), PDHA1(1), PDHA2(6), PDHB(4), PKLR(7)	15844517	184	83	174	63	52	51	3	34	42	2	0.553	1.000	1.000
362	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(3), AGTR1(2), ATF2(3), CALM1(2), CALM2(2), EGFR(15), ELK1(3), GNAQ(4), GRB2(4), JUN(4), MAP2K1(5), MAP2K2(3), MAP2K4(8), MAP3K1(11), MAPK1(3), MAPK3(1), MAPK8(5), MEF2A(2), MEF2B(5), MEF2C(4), MEF2D(7), PAK1(5), PRKCA(5), PTK2(11), PTK2B(16), RAF1(10), SHC1(7), SOS1(7), SRC(3), SYT1(4)	14383282	164	82	157	53	51	34	9	25	43	2	0.305	1.000	1.000
363	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCL11(1), CCR3(6), CFL1(1), GNAQ(4), GNAS(29), GNB1(1), GNGT1(3), LIMK1(5), MAP2K1(5), MAPK1(3), MAPK3(1), MYL2(8), NOX1(6), PIK3C2G(10), PLCB1(19), PPP1R12B(15), PRKCA(5), PTK2(11), RAF1(10), ROCK2(12)	10800778	155	82	147	38	58	27	4	30	35	1	0.103	1.000	1.000
364	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	29	AKT1(3), AVP(3), CABIN1(15), CALM1(2), CALM2(2), CAMK1(3), CAMK1G(6), HDAC5(10), IGF1(4), IGF1R(16), INSR(14), MAP2K6(1), MAPK14(1), MAPK7(6), MEF2A(2), MEF2B(5), MEF2C(4), MEF2D(7), MYOD1(6), NFATC1(13), NFATC2(17), PIK3R1(11), PPP3CA(10), PPP3CB(6), PPP3CC(5), SYT1(4), YWHAH(3)	13979056	179	82	173	64	61	43	6	29	39	1	0.270	1.000	1.000
365	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(6), AKR1B10(6), ALDOA(1), ALDOB(6), ALDOC(6), FBP1(4), FBP2(5), FPGT(5), FUK(5), GMDS(2), GMPPA(6), GMPPB(5), HK1(16), HK2(10), HK3(6), HSD3B7(6), KHK(2), LHPP(4), MPI(3), MTMR1(8), MTMR2(5), MTMR6(7), PFKFB1(6), PFKFB2(6), PFKFB3(7), PFKFB4(4), PFKL(5), PFKM(2), PFKP(14), PGM2(1), PHPT1(3), PMM1(2), PMM2(2), RDH11(1), RDH12(3), RDH13(5), SORD(2), TPI1(1), TSTA3(8)	15931702	196	82	190	59	73	55	5	27	36	0	0.0354	1.000	1.000
366	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(3), ACACA(22), ACACB(35), ACADM(4), ACAT1(5), ACAT2(4), ACSS1(12), ACSS2(10), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH6A1(6), ALDH9A1(4), EHHADH(7), HADHA(4), LDHA(3), LDHAL6B(5), LDHB(4), LDHC(1), MCEE(4), MLYCD(5), MUT(6), PCCA(8), PCCB(5), SUCLA2(4), SUCLG1(2), SUCLG2(5)	17041403	209	82	192	57	49	53	5	44	54	4	0.158	1.000	1.000
367	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(3), CAPN1(5), CAPN2(8), CAPNS1(2), CAPNS2(2), CXCR3(1), EGF(10), EGFR(15), ITGA1(8), ITGB1(10), MAPK1(3), MAPK3(1), MYL2(8), MYLK(22), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), PTK2(11), PXN(4), TLN1(23)	14031620	167	82	159	64	59	39	8	27	32	2	0.520	1.000	1.000
368	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	EGFR(15), ELK1(3), GNAS(29), GNB1(1), GNGT1(3), GRB2(4), IGF1R(16), ITGB1(10), KLK2(1), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK3(1), MKNK1(3), MKNK2(7), MYC(5), NGFR(4), PDGFRA(11), PPP2CA(4), PTPRR(11), RAF1(10), RPS6KA1(9), RPS6KA5(3), SHC1(7), SOS1(7), SRC(3), STAT3(7)	14218333	185	81	174	77	69	45	0	43	27	1	0.844	1.000	1.000
369	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(5), AASDH(7), AASDHPPT(1), AASS(7), ACAT1(5), ACAT2(4), ALDH1A1(7), ALDH1A2(5), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), BBOX1(4), DLST(4), DOT1L(11), EHHADH(7), EHMT1(14), EHMT2(12), GCDH(8), HADHA(4), PLOD1(7), PLOD2(12), PLOD3(16), SDS(4), SHMT1(2), SHMT2(9), TMLHE(5)	15854463	205	81	185	62	54	53	3	30	64	1	0.219	1.000	1.000
370	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	26	AKT1(3), AKT2(8), AKT3(6), BAD(3), BCL2(3), GRB2(4), GSK3A(3), GSK3B(5), IL4R(3), IRS1(24), IRS2(6), JAK1(12), JAK3(13), MAP4K1(4), MAPK1(3), MAPK3(1), PDK1(3), PIK3CD(11), PIK3R1(11), PPP1R13B(11), RAF1(10), SHC1(7), SOCS1(1), SOS1(7), SOS2(19), STAT6(3)	14742335	184	81	173	48	61	39	3	24	54	3	0.121	1.000	1.000
371	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	59	ATP12A(18), ATP4B(4), ATP6AP1(6), ATP6V0A1(5), ATP6V0A4(10), ATP6V0B(4), ATP6V0D1(8), ATP6V1A(6), ATP6V1B2(5), ATP6V1C1(2), ATP6V1C2(12), ATP6V1D(3), ATP6V1E1(2), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(7), ATP7A(12), ATP7B(12), COX10(2), COX4I1(6), COX6B1(2), COX7A1(1), COX7A2(1), COX7B(2), COX7C(1), NDUFA1(1), NDUFA10(4), NDUFA8(5), NDUFB2(1), NDUFB4(1), NDUFB5(1), NDUFB6(1), NDUFB7(1), NDUFS1(7), NDUFS2(5), NDUFV1(5), PPA2(3), SDHA(6), SDHB(4), SHMT1(2), UQCRB(1), UQCRC1(2), UQCRFS1(1)	15912824	187	80	180	63	58	45	8	35	40	1	0.454	1.000	1.000
372	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	BAD(3), BRAF(16), CREB1(3), CREB5(5), DUSP4(1), DUSP6(3), DUSP9(5), EEF2K(10), EIF4E(2), GRB2(4), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK3(1), MKNK1(3), MKNK2(7), MOS(11), NFKB1(7), RAP1A(2), RPS6KA1(9), RPS6KA2(9), RPS6KA3(4), SHC1(7), SOS1(7), SOS2(19), TRAF3(4)	12642981	153	80	143	60	40	34	3	33	41	2	0.878	1.000	1.000
373	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(3), CAMK2B(4), CAMK2D(3), CAMK2G(8), DAG1(13), ITPKA(2), ITPKB(11), ITPR1(24), ITPR2(30), ITPR3(36), NFAT5(10), PDE6A(4), PDE6B(10), PDE6C(4), PDE6D(1), PDE6G(1), SLC6A13(8), TF(15)	15339132	187	80	183	67	67	44	11	30	32	3	0.297	1.000	1.000
374	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM1(2), CALM2(2), CHUK(4), EGR2(8), EGR3(6), GNAQ(4), MAP3K1(11), MYC(5), NFATC1(13), NFATC2(17), NFKB1(7), NFKBIA(1), PLCG1(19), PPP3CA(10), PPP3CB(6), PPP3CC(5), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), RELA(5), SYT1(4), VIP(5), VIPR2(3)	12007552	168	80	159	48	59	35	3	31	40	0	0.0648	1.000	1.000
375	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(3), ACAA2(5), ACAD8(4), ACAD9(6), ADH1A(4), ADH1B(4), ADH4(2), ADH5(3), ADH6(7), ADH7(1), ADHFE1(9), AKR1B10(6), AKR1C4(6), AKR1D1(3), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), BAAT(4), CEL(10), CYP27A1(5), CYP7A1(6), HADHB(5), HSD3B7(6), LIPA(3), RDH11(1), RDH12(3), RDH13(5), SLC27A5(5), SOAT1(7), SOAT2(2), SRD5A1(3)	13577969	173	79	161	50	36	56	9	35	36	1	0.107	1.000	1.000
376	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	18	ADCY1(19), ARHGEF1(11), F2(9), F2R(3), F2RL3(3), GNA12(1), GNA13(5), GNAI1(1), GNAQ(4), GNB1(1), GNGT1(3), MAP3K7(10), PIK3R1(11), PLCB1(19), PPP1R12B(15), PRKCA(5), PTK2B(16), ROCK1(18)	10149452	154	79	151	50	46	39	2	27	37	3	0.401	1.000	1.000
377	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(8), CALM1(2), CALM2(2), CRKL(1), GNAQ(4), GRB2(4), JUN(4), MAP2K1(5), MAP2K2(3), MAP2K3(4), MAP2K4(8), MAP3K1(11), MAPK1(3), MAPK14(1), MAPK3(1), MAPK8(5), PAK1(5), PLCG1(19), PRKCA(5), PTK2B(16), RAF1(10), SHC1(7), SOS1(7), SRC(3), SYT1(4)	12217945	142	79	136	38	47	31	4	23	35	2	0.103	1.000	1.000
378	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(10), DYRK1B(12), GLI2(14), GLI3(47), GSK3B(5), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), SHH(4), SMO(13), SUFU(5)	7134953	141	79	134	52	51	25	5	30	28	2	0.426	1.000	1.000
379	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(3), DLG4(3), EPHB2(12), F2(9), F2RL1(2), F2RL2(3), F2RL3(3), JUN(4), MAP2K5(1), MAPK1(3), MAPK7(6), MAPK8(5), MYEF2(9), PLD1(19), PLD2(16), PLD3(6), PTK2(11), RAF1(10), RASAL1(7), SRC(3), TEC(4), VAV1(9)	11762632	148	79	147	43	51	35	6	24	30	2	0.124	1.000	1.000
380	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	25	AKT1(3), AKT2(8), AKT3(6), CISH(3), GRB2(4), IARS(10), IL13RA1(4), IL2RG(6), IL4(1), IL4R(3), INPP5D(4), JAK1(12), JAK2(13), JAK3(13), NR0B2(3), PI3(2), PPP1R13B(11), RPS6KB1(5), SERPINA4(2), SHC1(7), SOS1(7), SOS2(19), SRC(3), STAT6(3), TYK2(9)	14883760	161	79	153	48	38	39	2	30	50	2	0.561	1.000	1.000
381	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	39	APAF1(8), BAK1(4), BAX(6), BCL2(3), BID(2), BIRC2(3), BIRC3(6), CASP2(3), CASP3(2), CASP6(1), CASP7(3), CASP9(3), FADD(1), FAS(3), FASLG(3), GZMB(3), JUN(4), MAP2K4(8), MAP3K1(11), MAPK10(5), MCL1(1), MDM2(5), MYC(5), NFKB1(7), NFKBIA(1), PARP1(10), PRF1(8), RELA(5), RIPK1(2), TNF(3), TNFRSF1A(6), TNFRSF1B(3), TNFSF10(5), TRADD(2), TRAF1(3), TRAF2(4)	15184336	152	78	143	43	40	33	3	31	42	3	0.213	1.000	1.000
382	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(3), ACADL(2), ACADM(4), ACADSB(7), ALDH1A1(7), ALDH1A2(5), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), AOC2(6), AOC3(15), CNDP1(6), DPYD(16), DPYS(7), EHHADH(7), GAD1(7), GAD2(9), HADHA(4), MLYCD(5), SDS(4), SMS(5), UPB1(4)	12474673	168	78	151	47	35	41	2	35	54	1	0.168	1.000	1.000
383	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	39	ALG1(6), ALG10(11), ALG12(10), ALG13(8), ALG14(2), ALG2(2), ALG3(2), ALG5(3), ALG6(2), ALG8(4), ALG9(2), B4GALT1(2), B4GALT2(7), B4GALT3(2), DHDDS(4), DPAGT1(4), DPM1(1), FUT8(7), GANAB(12), MAN1A1(2), MAN1A2(5), MAN1B1(6), MAN1C1(8), MAN2A1(5), MGAT1(3), MGAT2(2), MGAT3(8), MGAT4A(5), MGAT4B(3), MGAT5(10), MGAT5B(5), RFT1(4), RPN1(3), RPN2(6), STT3B(5)	17534770	171	78	162	70	39	40	6	27	55	4	0.975	1.000	1.000
384	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B3GNT6(4), B4GALT5(6), C1GALT1(3), C1GALT1C1(7), GALNT1(4), GALNT10(7), GALNT11(6), GALNT12(3), GALNT13(8), GALNT14(10), GALNT2(5), GALNT3(4), GALNT4(5), GALNT5(12), GALNT6(6), GALNT7(2), GALNT8(6), GALNT9(3), GALNTL5(3), GCNT3(3), GCNT4(4), OGT(5), ST3GAL1(4), ST3GAL2(6), ST6GALNAC1(4), WBSCR17(25)	13869210	155	78	151	58	53	34	5	28	34	1	0.836	1.000	1.000
385	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAD(4), ALAS1(3), ALAS2(12), BLVRA(4), BLVRB(1), COX10(2), COX15(6), CP(10), CPOX(2), EARS2(3), EPRS(11), FECH(6), FTH1(4), FTMT(6), GUSB(11), HCCS(3), HMBS(3), HMOX1(5), HMOX2(1), MMAB(2), PPOX(5), UGT1A1(4), UGT1A10(1), UGT1A3(1), UGT1A4(3), UGT1A5(3), UGT1A6(6), UGT1A7(3), UGT1A9(3), UGT2A1(3), UGT2A3(6), UGT2B10(5), UGT2B11(1), UGT2B15(3), UGT2B17(2), UGT2B28(7), UGT2B4(4), UGT2B7(6), UROD(1), UROS(4)	18014594	170	78	169	58	35	48	8	43	36	0	0.574	1.000	1.000
386	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	23	POLA1(6), POLA2(4), POLB(4), POLD1(15), POLD2(4), POLD3(7), POLE(24), POLE2(4), POLE3(3), POLG(8), POLG2(5), POLH(6), POLI(2), POLK(8), POLL(3), POLQ(29), PRIM1(2), PRIM2(1), REV1(8), REV3L(38), RFC5(1)	17037861	182	78	179	57	48	41	4	29	58	2	0.594	1.000	1.000
387	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CCNH(2), ERCC3(8), GTF2B(4), GTF2E1(6), GTF2E2(2), GTF2F2(2), GTF2H1(2), GTF2H4(7), ILK(8), MNAT1(3), POLR1A(15), POLR1B(8), POLR2A(19), POLR2B(11), POLR2C(4), POLR2E(2), POLR2F(4), POLR2G(1), POLR2I(2), POLR2K(1), POLR3B(13), POLR3D(6), POLR3E(6), POLR3K(1), TAF13(1), TAF5(2), TAF6(12), TAF7(7), TBP(3)	15030146	162	78	159	44	56	41	2	23	39	1	0.0827	1.000	1.000
388	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	20	ATM(38), ATR(18), BRCA1(17), BRCA2(34), CHEK1(4), CHEK2(8), FANCA(7), FANCC(5), FANCD2(12), FANCE(7), FANCG(4), HUS1(2), MRE11A(5), RAD1(3), RAD17(6), RAD50(8), RAD51(1), RAD9A(4), TREX1(3)	18565736	186	77	174	43	32	44	3	35	67	5	0.292	1.000	1.000
389	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(19), EXT2(5), EXTL1(8), EXTL2(2), EXTL3(10), GLCE(5), HS2ST1(3), HS3ST1(3), HS3ST2(10), HS3ST3A1(2), HS3ST3B1(4), HS3ST5(8), HS6ST1(3), HS6ST2(7), HS6ST3(7), NDST1(11), NDST2(9), NDST3(13), NDST4(12)	8890710	141	77	136	47	43	35	4	38	18	3	0.454	1.000	1.000
390	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(3), ACAA2(5), ACADL(2), ACADM(4), ACADS(4), ACADSB(7), ACAT1(5), ACAT2(4), ALDH1A1(7), ALDH1A2(5), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH6A1(6), ALDH9A1(4), AOX1(12), BCAT1(5), BCKDHA(11), BCKDHB(3), EHHADH(7), HADHA(4), HADHB(5), HIBADH(3), IVD(4), MCCC1(3), MCCC2(3), MCEE(4), MUT(6), OXCT1(8), PCCA(8), PCCB(5), SDS(4)	15440430	192	77	176	64	37	58	3	33	58	3	0.663	1.000	1.000
391	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	23	ABL1(7), ATM(38), ATR(18), CCNA1(6), CCND1(1), CCNE1(5), CDC25A(6), CDK2(3), CDK6(4), CDKN1A(3), E2F1(3), GSK3B(5), HDAC1(5), RB1(13), SKP2(5), TFDP1(5), TGFB1(3), TGFB2(6), TGFB3(8)	12359948	144	76	138	47	31	39	3	27	41	3	0.608	1.000	1.000
392	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(5), ACP2(4), ACP5(2), ACPP(3), ACPT(4), ALPI(6), ALPL(8), ALPP(7), ALPPL2(5), CYP19A1(13), CYP1A1(5), CYP1A2(5), CYP2A13(8), CYP2A6(7), CYP2A7(3), CYP2B6(6), CYP2C18(4), CYP2C19(7), CYP2C8(1), CYP2D6(9), CYP2E1(6), CYP2F1(4), CYP2J2(3), CYP3A4(4), CYP3A7(4), CYP4B1(9), CYP51A1(8), PON1(2)	12601131	152	76	148	50	63	30	4	25	30	0	0.250	1.000	1.000
393	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	24	GH1(2), GHR(6), GRB2(4), INSR(14), IRS1(24), JAK2(13), MAP2K1(5), MAPK1(3), MAPK3(1), PIK3R1(11), PLCG1(19), PRKCA(5), PTPN6(4), RAF1(10), RPS6KA1(9), SHC1(7), SLC2A4(4), SOCS1(1), SOS1(7), SRF(2), STAT5A(3), STAT5B(14)	13260386	168	76	159	45	46	48	4	23	44	3	0.0740	1.000	1.000
394	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(6), AKR1B10(6), B4GALT1(2), B4GALT2(7), G6PC2(1), GAA(5), GALE(1), GALK1(4), GALK2(2), GALT(1), GANC(8), GCK(4), GLA(3), GLB1(5), HK1(16), HK2(10), HK3(6), HSD3B7(6), LALBA(1), LCT(23), MGAM(15), PFKL(5), PFKM(2), PFKP(14), PGM1(2), PGM3(7), RDH11(1), RDH12(3), RDH13(5), UGP2(7)	16536364	178	76	168	78	65	46	5	24	38	0	0.914	1.000	1.000
395	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(3), ACADM(4), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), AOC2(6), AOC3(15), CNDP1(6), DPYD(16), DPYS(7), EHHADH(7), GAD1(7), GAD2(9), HADHA(4), MLYCD(5), SMS(5), SRM(1), UPB1(4)	11585589	144	76	127	40	30	32	2	30	49	1	0.191	1.000	1.000
396	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSA(3), ARSD(4), ARSE(5), ASAH1(4), B4GALT6(4), CERK(6), DEGS1(1), DEGS2(1), ENPP7(4), GAL3ST1(8), GALC(5), GBA(9), GLA(3), GLB1(5), LCT(23), NEU1(3), NEU2(6), NEU3(5), NEU4(2), PPAP2A(3), PPAP2B(1), PPAP2C(4), SGMS1(3), SGMS2(3), SGPP1(2), SGPP2(1), SMPD1(6), SMPD2(3), SMPD3(9), SMPD4(4), SPHK1(6), SPHK2(3), SPTLC1(2), SPTLC2(3), UGCG(3), UGT8(5)	15329572	162	76	161	61	55	42	8	22	34	1	0.567	1.000	1.000
397	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	14	ATN1(8), BAIAP2(5), CASP1(4), CASP3(2), CASP7(3), GAPDH(2), INSR(14), ITCH(4), MAGI1(20), MAGI2(27), RERE(27), WWP1(12), WWP2(14)	9790586	142	76	134	38	38	33	6	21	43	1	0.119	1.000	1.000
398	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	ATF2(3), CDC42(1), CREB1(3), DAXX(10), DDIT3(4), ELK1(3), GRB2(4), HMGN1(2), HSPB2(1), MAP2K4(8), MAP2K6(1), MAP3K1(11), MAP3K5(5), MAP3K7(10), MAP3K9(3), MAPK14(1), MAPKAPK2(1), MAPKAPK5(3), MAX(3), MEF2A(2), MEF2B(5), MEF2C(4), MEF2D(7), MKNK1(3), MYC(5), PLA2G4A(6), RIPK1(2), RPS6KA5(3), SHC1(7), STAT1(10), TGFB1(3), TGFB2(6), TGFB3(8), TGFBR1(4), TRADD(2), TRAF2(4)	15731666	158	76	154	50	41	40	6	22	46	3	0.349	1.000	1.000
399	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	29	A1BG(1), AKT1(3), AKT2(8), AKT3(6), BAD(3), BTK(3), DAPP1(1), GRB2(4), GSK3A(3), GSK3B(5), IARS(10), INPP5D(4), PDK1(3), PPP1R13B(11), RPS6KA1(9), RPS6KA2(9), RPS6KA3(4), RPS6KB1(5), SFN(1), SHC1(7), SOS1(7), SOS2(19), TEC(4), YWHAB(2), YWHAE(2), YWHAG(1), YWHAH(3), YWHAQ(2), YWHAZ(3)	13753909	143	76	140	49	39	37	2	27	35	3	0.671	1.000	1.000
400	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	25	ADCY1(19), AKT1(3), CAMK2A(3), CAMK2B(4), CAMK2D(3), CAMK2G(8), CREB1(3), GNAS(29), GRB2(4), MAPK1(3), MAPK14(1), MAPK3(1), PIK3R1(11), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), PRKCA(5), RPS6KA1(9), RPS6KA5(3), SOS1(7)	11573022	147	75	141	49	53	38	1	19	34	2	0.462	1.000	1.000
401	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(18), ARHGEF1(11), GNA12(1), GNA13(5), GNAQ(4), GNB1(1), GNGT1(3), MYL2(8), MYLK(22), PLCB1(19), PPP1R12B(15), PRKCA(5), ROCK1(18)	8871982	130	75	122	39	33	30	2	25	36	4	0.480	1.000	1.000
402	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(38), MAP2(34), PPP1CA(2), PPP2CA(4), PRKACB(4), PRKACG(8), PRKAG1(4), PRKAR2A(2), PRKAR2B(8), PRKCE(14)	7793931	118	74	113	40	20	32	2	35	25	4	0.740	1.000	1.000
403	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(7), ACTN2(23), BCAR1(8), CSK(7), CTNNA1(15), CTNNA2(19), CTNNB1(22), PTK2(11), PXN(4), SRC(3), VCL(6)	8205698	125	74	120	48	36	26	8	26	26	3	0.732	1.000	1.000
404	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	38	ANAPC1(13), ANAPC10(2), ANAPC11(1), ANAPC2(7), ANAPC5(4), ANAPC7(6), BTRC(9), CDC16(7), CDC20(5), CDC23(6), CDC26(1), CDC27(3), CUL1(22), CUL2(6), CUL3(6), FBXW11(10), FZR1(7), ITCH(4), RBX1(1), SKP2(5), SMURF1(6), SMURF2(5), TCEB1(1), UBA1(4), UBE2D3(1), UBE2E3(3), VHL(2), WWP1(12), WWP2(14)	16490181	173	74	164	38	53	46	2	26	45	1	0.00749	1.000	1.000
405	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(4), CREBBP(40), DUSP1(2), EP300(22), IKBKB(8), IL1B(3), MAP2K3(4), MAP2K6(1), MAP3K7(10), MAPK11(1), MAPK14(1), MYD88(2), NFKB1(7), NFKBIA(1), NR3C1(6), RELA(5), TGFBR1(4), TGFBR2(14), TLR2(2), TNF(3)	12711671	140	74	138	37	35	34	7	27	36	1	0.0903	1.000	1.000
406	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(8), GTF2A1(3), GTF2B(4), GTF2E1(6), GTF2F1(5), HDAC3(6), NCOA1(17), NCOA2(22), NCOA3(16), NCOR2(30), POLR2A(19), RARA(3), RXRA(6), TBP(3)	10675277	148	74	144	48	44	47	4	25	28	0	0.285	1.000	1.000
407	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(9), ABAT(3), ACADS(4), ACAT1(5), ACAT2(4), ALDH1A1(7), ALDH1A2(5), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH5A1(6), ALDH9A1(4), EHHADH(7), GAD1(7), GAD2(9), HADHA(4), L2HGDH(2), OXCT1(8), PDHA1(1), PDHA2(6), PDHB(4), SDHB(4), SDS(4)	11064699	144	73	135	54	37	34	0	28	44	1	0.752	1.000	1.000
408	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(9), ACO1(8), ACO2(9), CLYBL(3), CS(3), DLD(4), DLST(4), FH(3), IDH1(2), IDH2(4), IDH3A(2), IDH3B(2), IDH3G(3), MDH1(3), OGDH(11), OGDHL(16), PC(15), PCK1(11), PCK2(9), SDHA(6), SDHB(4), SDHC(1), SDHD(1), SUCLA2(4), SUCLG1(2), SUCLG2(5)	12830038	144	73	137	46	52	32	6	19	30	5	0.296	1.000	1.000
409	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	21	ALDH1A3(6), ALDH3A1(11), ALDH3B1(4), ALDH3B2(7), AOC2(6), AOC3(15), EPX(9), GOT1(3), GOT2(2), HPD(1), LPO(9), MAOA(2), MAOB(3), MPO(7), PRDX1(1), PRDX2(2), PRDX5(1), PRDX6(2), TAT(5), TPO(24)	8992015	120	73	108	40	35	19	4	33	27	2	0.649	1.000	1.000
410	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	12	CREBBP(40), DAXX(10), PAX3(11), PML(12), RARA(3), RB1(13), SIRT1(6), SP100(15), TNF(3), TNFRSF1A(6), TNFRSF1B(3)	7805750	122	73	119	31	41	34	2	16	29	0	0.0344	1.000	1.000
411	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(3), CDC42(1), CREB1(3), CREB5(5), DUSP1(2), DUSP10(8), EEF2K(10), EIF4E(2), ELK1(3), IL1R1(4), MAP2K3(4), MAP2K4(8), MAP2K6(1), MAP3K10(8), MAP3K4(21), MAP3K5(5), MAP3K7(10), MAPK1(3), MAPK11(1), MAPK13(3), MAPK14(1), MAPKAPK2(1), MAPKAPK5(3), MKNK1(3), MKNK2(7), MYEF2(9), NFKB1(7), NR2C2(3), SRF(2), TRAF6(6)	14301914	147	73	145	47	36	43	9	25	33	1	0.217	1.000	1.000
412	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(29), COL4A2(13), COL4A3(13), COL4A4(15), COL4A5(14), COL4A6(9), P4HB(4), SLC23A1(5), SLC23A2(11), SLC2A1(6), SLC2A3(8)	10760945	127	73	124	48	37	36	3	25	25	1	0.396	1.000	1.000
413	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	18	ABL1(7), ATM(38), BRCA1(17), CDKN1A(3), CHEK1(4), CHEK2(8), JUN(4), MAPK8(5), MDM2(5), MRE11A(5), NFKB1(7), NFKBIA(1), RAD50(8), RAD51(1), RBBP8(7), RELA(5), TP73(5)	12429810	130	72	122	35	23	28	4	27	44	4	0.436	1.000	1.000
414	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	21	ADCY1(19), AKT1(3), ASAH1(4), GNAI1(1), GNB1(1), GNGT1(3), ITGAV(13), ITGB3(7), MAPK1(3), MAPK3(1), PDGFA(2), PDGFRA(11), PIK3R1(11), PLCB1(19), PRKCA(5), PTK2(11), SMPD1(6), SMPD2(3), SPHK1(6), SRC(3)	10836767	132	72	127	51	37	41	4	15	34	1	0.647	1.000	1.000
415	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(6), B4GALT1(2), B4GALT2(7), FBP2(5), GAA(5), GALE(1), GALK1(4), GALK2(2), GALT(1), GANAB(12), GCK(4), GLA(3), GLB1(5), HK1(16), HK2(10), HK3(6), LALBA(1), LCT(23), MGAM(15), PFKM(2), PFKP(14), PGM1(2), PGM3(7)	13947676	153	72	144	64	57	38	4	19	35	0	0.831	1.000	1.000
416	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	21	AKT1(3), BCL2(3), BCR(11), CRKL(1), FOS(1), GRB2(4), JAK2(13), JUN(4), MAP2K1(5), MAP2K4(8), MAP3K1(11), MAPK3(1), MAPK8(5), MYC(5), PIK3R1(11), RAF1(10), SOS1(7), STAT1(10), STAT5A(3), STAT5B(14)	11116734	130	72	121	33	27	36	1	23	39	4	0.0908	1.000	1.000
417	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(4), CHIA(4), CHIT1(4), CMAS(7), CTBS(3), CYB5R1(3), CYB5R3(4), GFPT1(4), GFPT2(5), GNE(7), GNPDA1(4), GNPDA2(6), GNPNAT1(4), HEXA(2), HEXB(3), HK1(16), HK2(10), HK3(6), LHPP(4), MTMR1(8), MTMR2(5), MTMR6(7), NAGK(2), NANS(3), NPL(3), PGM3(7), PHPT1(3), RENBP(2), UAP1(5)	12309781	145	72	143	40	38	41	6	27	33	0	0.0517	1.000	1.000
418	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(8), AGT(3), AGTR1(2), AGTR2(4), CMA1(1), COL4A1(29), COL4A2(13), COL4A3(13), COL4A4(15), COL4A5(14), COL4A6(9), REN(4)	10842746	115	71	113	37	31	30	4	25	24	1	0.221	1.000	1.000
419	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	CALM1(2), CALM2(2), CDKN1A(3), GNAQ(4), MARCKS(3), NFATC1(13), NFATC2(17), NFATC3(4), NFATC4(16), PLCG1(19), PPP3CA(10), PPP3CB(6), PPP3CC(5), PRKCA(5), SP1(6), SP3(3), SYT1(4)	9006258	122	71	117	37	44	31	3	16	28	0	0.0992	1.000	1.000
420	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5(2), CDK5R1(4), CSNK1D(2), DRD1(3), DRD2(9), GRM1(31), PLCB1(19), PPP1CA(2), PPP1R1B(1), PPP2CA(4), PPP3CA(10), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8)	6867076	118	71	113	42	40	29	1	18	30	0	0.490	1.000	1.000
421	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(6), ALDOA(1), ALDOB(6), ALDOC(6), FBP1(4), FBP2(5), FPGT(5), GCK(4), GMDS(2), GMPPA(6), GMPPB(5), HK1(16), HK2(10), HK3(6), KHK(2), MPI(3), PFKFB1(6), PFKFB3(7), PFKFB4(4), PFKM(2), PFKP(14), PMM1(2), PMM2(2), SORD(2), TPI1(1)	10274441	127	71	122	38	51	33	3	18	22	0	0.0670	1.000	1.000
422	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ACY1(3), AGMAT(2), ALDH18A1(7), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), AMD1(5), AOC2(6), AOC3(15), ARG1(2), ARG2(2), ASL(6), ASS1(9), CPS1(22), GATM(3), MAOA(2), MAOB(3), NAGS(1), ODC1(4), OTC(2), SAT1(1), SMS(5), SRM(1)	12641840	146	71	131	35	35	36	4	32	38	1	0.0739	1.000	1.000
423	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	33	AKT1(3), BAD(3), BCL2(3), CBL(3), CFLAR(1), CRKL(1), E2F1(3), FOS(1), GRB2(4), IL2RA(3), IL2RB(2), IL2RG(6), IRS1(24), JAK1(12), JAK3(13), MAPK1(3), MAPK3(1), MYC(5), NMI(1), PIK3R1(11), PTPN6(4), RAF1(10), RPS6KB1(5), SHC1(7), SOCS1(1), SOCS3(3), SOS1(7), STAT5A(3), STAT5B(14), SYK(7)	14558500	164	71	154	47	40	46	2	25	49	2	0.296	1.000	1.000
424	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(9), F2R(3), F2RL3(3), GNAI1(1), GNB1(1), GNGT1(3), ITGA1(8), ITGB1(10), MAP2K1(5), MAPK1(3), MAPK3(1), PLA2G4A(6), PLCB1(19), PRKCA(5), PTGS1(12), PTK2(11), RAF1(10), SRC(3), SYK(7), TBXAS1(6)	10447613	126	71	120	47	46	25	6	25	24	0	0.521	1.000	1.000
425	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	31	APAF1(8), BCL2(3), BID(2), BIRC2(3), BIRC3(6), CASP10(6), CASP3(2), CASP6(1), CASP7(3), CASP9(3), CFLAR(1), CHUK(4), DFFA(4), DFFB(3), FADD(1), GAS2(2), LMNA(6), NFKB1(7), NFKBIA(1), RELA(5), RIPK1(2), SPTAN1(21), TNFRSF10A(1), TNFRSF10B(2), TNFRSF25(4), TNFSF10(5), TRADD(2), TRAF2(4)	13818875	112	70	109	33	29	26	2	26	28	1	0.406	1.000	1.000
426	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(3), EPHA4(17), EPHB1(23), FYN(10), ITGA1(8), ITGB1(10), L1CAM(16), LYN(5), RAP1B(6), SELP(10)	6780295	108	70	103	37	38	19	8	31	11	1	0.269	1.000	1.000
427	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	21	ACTA1(3), ADCY1(19), CAP1(2), CCNB1(3), GNAI1(1), GNAS(29), GNB1(1), GNGT1(3), MAPK1(3), MAPK3(1), MYT1(19), PIN1(2), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), RPS6KA1(9), SRC(3)	8428380	129	70	123	53	50	31	1	25	22	0	0.771	1.000	1.000
428	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(4), ASNS(4), ASRGL1(2), CA1(1), CA12(1), CA13(5), CA14(5), CA2(5), CA3(5), CA4(5), CA5A(1), CA5B(1), CA6(3), CA7(4), CA8(4), CA9(6), CPS1(22), CTH(2), GLS(10), GLS2(7), GLUD1(2), GLUD2(11), GLUL(5), HAL(4)	9110531	119	69	114	40	27	36	4	29	23	0	0.470	1.000	1.000
429	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	19	CSNK2A1(5), ELK1(3), FOS(1), GRB2(4), IGF1(4), IGF1R(16), IRS1(24), JUN(4), MAP2K1(5), MAPK3(1), MAPK8(5), PIK3R1(11), PTPN11(6), RAF1(10), RASA1(17), SHC1(7), SOS1(7), SRF(2)	9709668	132	69	124	36	34	31	3	24	37	3	0.161	1.000	1.000
430	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(4), IFNA1(1), IFNB1(3), IKBKB(8), IL1A(2), IL1B(3), IL1R1(4), IL1RAP(7), IL1RN(2), IRAK1(6), IRAK2(7), IRAK3(6), JUN(4), MAP2K3(4), MAP2K6(1), MAP3K1(11), MAP3K7(10), MAPK14(1), MAPK8(5), MYD88(2), NFKB1(7), NFKBIA(1), RELA(5), TGFB1(3), TGFB2(6), TGFB3(8), TNF(3), TOLLIP(5), TRAF6(6)	12735275	135	69	132	34	35	28	4	29	37	2	0.0855	1.000	1.000
431	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	CHUK(4), FADD(1), IKBKB(8), IL1A(2), IL1R1(4), IRAK1(6), MAP3K1(11), MAP3K7(10), MYD88(2), NFKB1(7), NFKBIA(1), RELA(5), RIPK1(2), TLR4(21), TNF(3), TNFAIP3(10), TNFRSF1A(6), TNFRSF1B(3), TRADD(2), TRAF6(6)	10426604	114	69	109	31	27	22	5	30	30	0	0.210	1.000	1.000
432	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	CBL(3), EGF(10), EGFR(15), GRB2(4), MAP2K1(5), MAPK1(3), MAPK3(1), PTPRB(21), RAF1(10), RASA1(17), SHC1(7), SOS1(7), SPRY1(3), SPRY3(6), SPRY4(5), SRC(3)	10713395	120	69	115	39	32	25	3	31	29	0	0.552	1.000	1.000
433	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	14	AKT1(3), BCL2(3), EGFR(15), IGF1R(16), MYC(5), POLR2A(19), PPP2CA(4), PRKCA(5), RB1(13), TEP1(29), TERF1(5), TERT(4), TNKS(19), XRCC5(10)	11763574	150	69	145	61	36	48	5	27	34	0	0.777	1.000	1.000
434	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(5), GPLD1(11), PGAP1(8), PIGA(3), PIGB(10), PIGC(6), PIGF(1), PIGG(12), PIGK(3), PIGL(4), PIGM(5), PIGN(7), PIGO(12), PIGP(1), PIGQ(7), PIGS(4), PIGT(8), PIGU(1), PIGV(7), PIGW(3), PIGX(2), PIGZ(4)	10172108	124	68	111	35	29	29	2	25	36	3	0.352	1.000	1.000
435	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(30), C5(11), C6(12), C7(3), ICAM1(2), IL1A(2), ITGA4(12), ITGAL(16), ITGB1(10), ITGB2(6), SELP(10), SELPLG(7), TNF(3), VCAM1(10)	10638910	134	68	126	43	44	29	3	34	24	0	0.162	1.000	1.000
436	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	19	AKT1(3), EIF4A1(3), EIF4A2(6), EIF4B(5), EIF4E(2), EIF4EBP1(2), EIF4G1(23), EIF4G2(7), EIF4G3(17), FKBP1A(2), MKNK1(3), PDPK1(2), PIK3R1(11), PPP2CA(4), RPS6(1), RPS6KB1(5), TSC1(7), TSC2(12)	10558822	115	68	110	29	32	28	4	22	28	1	0.173	1.000	1.000
437	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(3), ACACA(22), ACADL(2), ACADM(4), ACADSB(7), ACAT1(5), ACAT2(4), ALDH1A1(7), ALDH1A2(5), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH6A1(6), ALDH9A1(4), EHHADH(7), HADHA(4), LDHA(3), LDHB(4), LDHC(1), MCEE(4), MLYCD(5), MUT(6), PCCA(8), PCCB(5), SDS(4), SUCLA2(4), SUCLG1(2), SUCLG2(5)	14214282	172	68	158	49	36	53	2	33	45	3	0.302	1.000	1.000
438	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	21	ADCY1(19), AKT1(3), BAD(3), BAX(6), BCL2(3), CSF2RB(9), IGF1(4), IGF1R(16), IL3(1), IL3RA(5), KIT(12), KITLG(3), PIK3R1(11), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), YWHAH(3)	8479948	129	67	121	52	36	38	3	22	29	1	0.703	1.000	1.000
439	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(9), CS(3), DLAT(3), DLD(4), DLST(4), FH(3), IDH2(4), IDH3A(2), IDH3B(2), IDH3G(3), MDH1(3), OGDH(11), PC(15), PDHA1(1), PDHA2(6), PDHB(4), PDHX(5), PDK1(3), PDK3(4), PDK4(2), PDP2(4), SDHA(6), SDHB(4), SDHC(1), SDHD(1), SUCLA2(4), SUCLG1(2), SUCLG2(5)	12176274	118	67	113	50	33	31	4	21	26	3	0.915	1.000	1.000
440	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	30	DUSP1(2), GORASP1(4), MAP2K4(8), MAPK1(3), MAPK10(5), MAPK11(1), MAPK13(3), MAPK14(1), MAPK3(1), MAPK8(5), MAPK8IP1(4), MAPK8IP2(4), MAPK8IP3(13), MAPK9(3), MAPKAPK5(3), NFKB1(7), NFKB2(7), NFKBIA(1), NFKBIB(6), NFKBIL1(4), PIK3CD(11), PIK3R1(11), SYT1(4), TRAF2(4), TRAF3(4), TRAF5(1), TRAF6(6)	13169944	126	67	122	34	42	28	2	18	31	5	0.0985	1.000	1.000
441	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(3), ACAA2(5), ADH1A(4), ADH1B(4), ADH4(2), ADH6(7), ADH7(1), ADHFE1(9), AKR1C4(6), AKR1D1(3), ALDH1A1(7), ALDH1A2(5), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), BAAT(4), CEL(10), CYP27A1(5), CYP7A1(6), HADHB(5), SOAT2(2), SRD5A1(3)	9967366	136	66	127	41	26	40	5	29	35	1	0.251	1.000	1.000
442	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(19), GNAS(29), GNB1(1), GNGT1(3), PPP2CA(4), PRKAA1(6), PRKAA2(7), PRKAB1(6), PRKAB2(4), PRKACB(4), PRKACG(8), PRKAG1(4), PRKAG2(5), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8)	6605217	119	66	112	38	46	24	1	18	28	2	0.537	1.000	1.000
443	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	28	ATG12(1), ATG5(3), ATG7(5), BECN1(7), GABARAPL1(5), IFNA1(1), IFNA10(4), IFNA13(1), IFNA16(4), IFNA2(1), IFNA4(1), IFNA5(2), IFNA6(3), IFNA7(4), IFNA8(1), IFNG(2), PIK3C3(14), PIK3R4(11), PRKAA1(6), PRKAA2(7), ULK1(16), ULK2(11)	8880754	110	66	105	30	23	21	7	30	28	1	0.323	1.000	1.000
444	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(15), CALM1(2), CALM2(2), CAPN2(8), CAPNS1(2), CAPNS2(2), EP300(22), HDAC1(5), HDAC2(2), MEF2D(7), NFATC1(13), NFATC2(17), PPP3CA(10), PPP3CB(6), PPP3CC(5), PRKCA(5), SYT1(4)	10479130	127	65	121	34	49	27	3	21	26	1	0.0404	1.000	1.000
445	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	26	ANXA1(2), ANXA2(3), ANXA3(1), ANXA4(3), ANXA5(3), ANXA6(2), CYP11A1(5), EDN1(3), EDNRA(4), HSD11B1(3), HSD11B2(3), PLA2G4A(6), PRL(1), PTGDR(7), PTGDS(1), PTGER2(5), PTGER4(8), PTGFR(5), PTGIS(6), PTGS1(12), PTGS2(7), S100A6(1), SCGB1A1(2), TBXAS1(6)	8457480	99	65	98	39	27	25	7	23	17	0	0.744	1.000	1.000
446	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(5), CREB1(3), CREBBP(40), EP300(22), NCOA3(16), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8), RARA(3), RXRA(6)	8872206	126	64	121	37	39	34	2	16	33	2	0.165	1.000	1.000
447	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	23	ALDH1A1(7), ALDH1A2(5), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH3B1(4), ALDH3B2(7), ALDH9A1(4), AOC2(6), AOC3(15), ASPA(1), CNDP1(6), HAL(4), HARS(9), HDC(8), HNMT(2), MAOA(2), MAOB(3), PRPS1(3), PRPS2(3)	10050972	130	64	115	36	37	25	3	25	38	2	0.314	1.000	1.000
448	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(5), CARM1(5), CBS(6), CTH(2), GGT1(6), HEMK1(1), LCMT1(1), LCMT2(11), MARS(4), MARS2(2), MAT1A(4), MAT2B(3), METTL6(3), PAPSS1(6), PAPSS2(5), PRMT2(8), PRMT3(5), PRMT5(3), PRMT6(4), PRMT7(6), PRMT8(9), SCLY(2), SEPHS1(4), SEPHS2(2), WBSCR22(6)	10696394	113	64	106	43	31	26	6	16	33	1	0.650	1.000	1.000
449	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(2), GALNS(1), GLB1(5), GNS(5), GUSB(11), HEXA(2), HEXB(3), HGSNAT(5), HPSE(8), HPSE2(5), HYAL1(6), HYAL2(5), IDS(4), IDUA(4), LCT(23), NAGLU(6), SPAM1(9)	8767957	104	64	103	36	33	31	4	17	18	1	0.427	1.000	1.000
450	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(3), B3GNT2(3), B3GNT7(5), B4GALT1(2), B4GALT2(7), B4GALT3(2), B4GALT4(5), CHST1(14), CHST2(14), CHST4(6), CHST6(11), FUT8(7), ST3GAL1(4), ST3GAL2(6), ST3GAL3(2), ST3GAL4(6)	5365973	97	64	94	33	50	18	1	12	16	0	0.348	1.000	1.000
451	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	21	AOX1(12), BST1(3), CD38(4), ENPP1(7), ENPP3(8), NADK(10), NADSYN1(8), NMNAT1(3), NMNAT2(1), NMNAT3(2), NNMT(1), NNT(12), NT5C(1), NT5C1A(5), NT5C1B(6), NT5C2(8), NT5E(2), NUDT12(4)	9071950	97	64	92	39	24	26	5	16	25	1	0.776	1.000	1.000
452	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(3), AP2A1(9), AP2M1(7), ARF1(5), BAD(3), BTK(3), EEA1(13), GRASP(1), GSK3A(3), GSK3B(5), LYN(5), PDPK1(2), PFKL(5), PFKM(2), PFKP(14), PLCG1(19), PRKCE(14), RAB5A(2), RPS6KB1(5), VAV2(12)	10720354	132	64	125	39	41	32	7	21	29	2	0.168	1.000	1.000
453	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(6), ABAT(3), ADSL(5), ADSS(5), AGXT(1), AGXT2(8), ASL(6), ASNS(4), ASPA(1), CAD(17), CRAT(5), DARS(2), DDO(6), GAD1(7), GAD2(9), GOT1(3), GOT2(2), GPT(3), GPT2(5), NARS(5), PC(15)	11174678	118	63	115	49	41	30	0	21	26	0	0.776	1.000	1.000
454	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(9), CD2(3), CD33(6), CD5(4), CD7(5), IFNA1(1), IFNB1(3), IFNG(2), IL10(2), IL12A(2), IL12B(2), IL13(2), IL3(1), IL4(1), ITGAX(14), TLR2(2), TLR4(21), TLR7(5), TLR9(15)	7990479	100	63	94	46	28	21	5	33	13	0	0.907	1.000	1.000
455	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(6), FUCA1(1), FUCA2(2), GLB1(5), HEXA(2), HEXB(3), LCT(23), MAN2B1(17), MAN2B2(18), MAN2C1(11), MANBA(7), NEU1(3), NEU2(6), NEU3(5), NEU4(2)	8731153	111	63	108	35	36	24	4	19	28	0	0.375	1.000	1.000
456	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(40), EP300(22), LPL(7), NCOA1(17), NCOA2(22), PPARG(4), RXRA(6)	7927613	118	63	114	30	35	32	5	23	22	1	0.0490	1.000	1.000
457	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CHUK(4), CREBBP(40), EP300(22), FADD(1), HDAC3(6), IKBKB(8), NFKB1(7), NFKBIA(1), RELA(5), RIPK1(2), TNF(3), TNFRSF1A(6), TNFRSF1B(3), TRADD(2), TRAF6(6)	9586705	116	63	114	33	35	29	3	19	29	1	0.147	1.000	1.000
458	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(18), APOA1(8), APOA4(5), APOC2(2), APOE(2), CETP(5), CYP7A1(6), DGAT1(3), HMGCR(7), LCAT(4), LDLR(10), LIPC(4), LPL(7), LRP1(47), SCARB1(4), SOAT1(7)	11773166	139	63	129	51	50	25	10	26	24	4	0.591	1.000	1.000
459	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(6), CARS(5), DARS(2), EPRS(11), FARS2(7), GARS(4), HARS(9), IARS(10), KARS(5), LARS(5), LARS2(8), MARS(4), MARS2(2), NARS(5), QARS(5), RARS(5), SARS(8), TARS(7), WARS(5), WARS2(10), YARS(6)	13750028	129	62	126	34	39	36	4	23	27	0	0.0959	1.000	1.000
460	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	30	AKR1B10(6), ALOX15(7), ALOX5(10), CYP1A2(5), CYP2C18(4), CYP2C19(7), CYP2C8(1), CYP2E1(6), CYP2J2(3), CYP3A4(4), CYP3A43(4), CYP3A7(4), HSD3B7(6), PLA2G10(1), PLA2G12A(2), PLA2G12B(2), PLA2G2A(2), PLA2G2D(1), PLA2G2E(4), PLA2G3(9), PLA2G4A(6), PLA2G5(1), PLA2G6(6), RDH11(1), RDH12(3), RDH13(5)	10139132	110	62	109	36	36	34	4	21	15	0	0.245	1.000	1.000
461	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(4), ASNS(4), CA1(1), CA12(1), CA14(5), CA2(5), CA3(5), CA4(5), CA5A(1), CA5B(1), CA6(3), CA7(4), CA8(4), CA9(6), CPS1(22), CTH(2), GLS(10), GLS2(7), GLUD1(2), GLUL(5), HAL(4)	8154405	101	62	96	37	21	32	3	22	23	0	0.690	1.000	1.000
462	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	14	AANAT(2), ACHE(11), CHAT(4), COMT(4), DBH(6), GAD1(7), GAD2(9), HDC(8), MAOA(2), PAH(6), PNMT(8), SLC18A3(13), TH(3), TPH1(3)	5744224	86	61	85	43	32	14	2	20	17	1	0.888	1.000	1.000
463	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(7), B4GALNT1(5), GLB1(5), HEXA(2), HEXB(3), LCT(23), SLC33A1(5), ST3GAL1(4), ST3GAL2(6), ST3GAL5(3), ST6GALNAC3(8), ST6GALNAC4(2), ST6GALNAC5(3), ST6GALNAC6(4), ST8SIA1(7), ST8SIA5(8)	7066627	95	61	93	39	38	16	5	18	18	0	0.801	1.000	1.000
464	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	CSNK2A1(5), ELK1(3), FOS(1), GRB2(4), IL6R(2), IL6ST(6), JAK1(12), JAK2(13), JAK3(13), JUN(4), MAP2K1(5), MAPK3(1), PTPN11(6), RAF1(10), SHC1(7), SOS1(7), SRF(2), STAT3(7)	10248426	108	61	104	39	25	33	1	29	19	1	0.593	1.000	1.000
465	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	26	BAG4(2), BIRC2(3), BIRC3(6), CASP3(2), CFLAR(1), FADD(1), JUN(4), MAP2K4(8), MAP3K3(8), MAP3K7(10), NFKB1(7), NFKB2(7), NFKBIA(1), NFKBIB(6), NFKBIL1(4), NR2C2(3), RALBP1(8), RIPK1(2), TNF(3), TNFAIP3(10), TNFRSF1A(6), TNFRSF1B(3), TRADD(2), TRAF2(4)	11182344	111	61	109	34	33	23	5	19	29	2	0.422	1.000	1.000
466	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(19), ADRB2(8), CFTR(14), GNAS(29), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8)	5625929	101	60	96	38	40	23	0	18	20	0	0.758	1.000	1.000
467	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSA(3), ARSB(2), ARSD(4), ARSE(5), ASAH1(4), GAL3ST1(8), GALC(5), GBA(9), GLA(3), GLB1(5), LCT(23), NEU1(3), NEU2(6), NEU3(5), NEU4(2), PPAP2A(3), PPAP2B(1), PPAP2C(4), SMPD1(6), SMPD2(3), SPTLC1(2), SPTLC2(3), UGCG(3)	10372839	112	60	111	41	37	32	6	14	23	0	0.528	1.000	1.000
468	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	36	ANPEP(9), G6PD(5), GCLC(3), GCLM(3), GGT1(6), GPX2(3), GPX3(1), GPX5(2), GPX6(5), GPX7(3), GSR(5), GSS(3), GSTA1(3), GSTA2(2), GSTA3(1), GSTA4(2), GSTA5(2), GSTK1(1), GSTM2(1), GSTM3(2), GSTM4(3), GSTM5(2), GSTO2(3), GSTP1(1), GSTZ1(3), IDH1(2), IDH2(4), MGST1(3), MGST2(3), MGST3(3), OPLAH(15), TXNDC12(1)	9412179	105	60	97	33	27	23	2	23	30	0	0.521	1.000	1.000
469	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(15), POLR1B(8), POLR1C(3), POLR1D(4), POLR2A(19), POLR2B(11), POLR2C(4), POLR2E(2), POLR2F(4), POLR2G(1), POLR2I(2), POLR2K(1), POLR3A(17), POLR3B(13), POLR3G(2), POLR3K(1), ZNRD1(1)	10075177	108	60	106	30	40	30	1	21	16	0	0.0846	1.000	1.000
470	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(10), ACE2(8), AGT(3), AGTR1(2), AGTR2(4), ANPEP(9), CMA1(1), CPA3(1), CTSA(4), CTSG(3), ENPEP(12), LNPEP(11), MAS1(2), MME(8), NLN(6), REN(4), THOP1(4)	9073726	92	60	88	37	27	23	4	17	21	0	0.752	1.000	1.000
471	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(5), ELK1(3), FOS(1), GRB2(4), IL2RA(3), IL2RB(2), IL2RG(6), JAK1(12), JAK3(13), JUN(4), LCK(4), MAP2K1(5), MAPK3(1), MAPK8(5), RAF1(10), SHC1(7), SOS1(7), STAT5A(3), STAT5B(14), SYK(7)	9999634	116	60	108	30	28	33	1	25	28	1	0.138	1.000	1.000
472	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(19), ADRB2(8), GNAS(29), PLCE1(14), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8)	6367978	101	60	96	44	44	25	0	15	17	0	0.848	1.000	1.000
473	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(3), CSF1R(15), EGF(10), EGFR(15), GRB2(4), MET(8), PDGFRA(11), PRKCA(5), SH3GLB1(3), SH3GLB2(7), SH3KBP1(15), SRC(3)	8346713	99	59	92	44	28	22	3	17	29	0	0.929	1.000	1.000
474	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(2), CSF1R(15), DDX20(4), E2F1(3), ETS1(8), ETS2(4), FOS(1), HDAC2(2), HDAC5(10), JUN(4), NCOR2(30), RBL1(11), RBL2(8), SIN3A(14), SIN3B(12)	11107755	128	59	124	44	35	22	5	29	37	0	0.717	1.000	1.000
475	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(17), IL13(2), IL4(1), JUNB(3), MAF(3), MAP2K3(4), MAPK14(1), NFATC1(13), NFATC2(17), PRKACB(4), PRKACG(8), PRKAR1A(3), PRKAR1B(6), PRKAR2A(2), PRKAR2B(8)	5203055	92	59	85	31	36	21	1	11	23	0	0.193	1.000	1.000
476	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(5), BCAT2(6), IARS(10), IARS2(9), ILVBL(5), LARS(5), LARS2(8), PDHA1(1), PDHA2(6), PDHB(4), VARS(16), VARS2(12)	7978229	87	58	87	30	27	21	2	21	16	0	0.533	1.000	1.000
477	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(11), AMT(4), ATIC(6), FTCD(5), GART(9), MTFMT(1), MTHFD1(5), MTHFD1L(6), MTHFD2(1), MTHFR(9), MTHFS(3), MTR(13), SHMT1(2), SHMT2(9), TYMS(1)	8109297	85	58	82	29	23	18	3	15	24	2	0.339	1.000	1.000
478	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOA(1), ALDOB(6), ALDOC(6), FBP1(4), FBP2(5), GOT1(3), GOT2(2), GPT(3), GPT2(5), MDH1(3), ME1(2), ME3(4), PGK1(4), PGK2(3), PKLR(7), RPE(5), RPIA(2), TKT(4), TKTL1(10), TKTL2(12), TPI1(1)	8666919	92	58	90	37	29	25	4	19	15	0	0.647	1.000	1.000
479	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(6), ALDH1A3(6), ALDH1B1(7), ALDH2(9), ALDH3A1(11), ALDH3A2(8), ALDH9A1(4), CYP2C19(7), DHRS1(2), DHRS3(2), DHRS7(6), DHRSX(5), EHHADH(7), ESCO1(7), ESCO2(8), HADHA(4), NAT6(3), PNPLA3(2), SH3GLB1(3), YOD1(2)	13265815	109	58	99	30	26	28	1	17	36	1	0.317	1.000	1.000
480	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(5), IL22(1), IL22RA1(2), IL22RA2(1), JAK1(12), JAK2(13), JAK3(13), SOCS3(3), STAT1(10), STAT3(7), STAT5A(3), STAT5B(14), TYK2(9)	7875134	93	58	89	30	20	25	1	20	26	1	0.564	1.000	1.000
481	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(16), ABCC2(12), ABCG2(6), BCHE(18), CES1(7), CES2(8), CYP3A4(4), UGT1A1(4), UGT1A10(1), UGT1A3(1), UGT1A4(3), UGT1A5(3), UGT1A6(6), UGT1A7(3), UGT1A9(3)	9818652	95	58	93	34	21	26	2	26	19	1	0.634	1.000	1.000
482	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	CASP2(3), CHUK(4), CRADD(1), IKBKB(8), JUN(4), LTA(4), MAP2K3(4), MAP2K4(8), MAP2K6(1), MAP3K1(11), MAP4K2(8), MAPK14(1), MAPK8(5), NFKB1(7), NFKBIA(1), RELA(5), RIPK1(2), TANK(3), TNF(3), TNFRSF1A(6), TRADD(2), TRAF2(4)	10323491	95	58	93	28	22	19	5	14	32	3	0.401	1.000	1.000
483	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(8), ACO2(9), CS(3), DLD(4), DLST(4), FH(3), IDH1(2), IDH2(4), IDH3A(2), IDH3B(2), IDH3G(3), MDH1(3), PC(15), PCK1(11), SDHA(6), SDHB(4), SUCLA2(4), SUCLG1(2), SUCLG2(5)	8846734	94	57	88	31	36	21	2	14	19	2	0.360	1.000	1.000
484	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(4), POLD1(15), POLD2(4), POLE(24), POLG(8), POLL(3), POLQ(29)	7187553	87	57	85	34	27	16	3	16	24	1	0.831	1.000	1.000
485	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(7), F2(9), F2R(3), F3(1), F5(21), F7(10), FGA(9), FGB(4), FGG(3), PROC(3), PROS1(9), SERPINC1(4), TFPI(4)	7040319	87	57	87	27	25	20	4	27	11	0	0.369	1.000	1.000
486	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOA(1), ALDOB(6), ALDOC(6), FBP1(4), FBP2(5), G6PD(5), GPI(5), H6PD(6), PFKL(5), PFKM(2), PFKP(14), PGD(6), PGLS(2), PGM1(2), PGM3(7), PRPS1(3), PRPS1L1(2), PRPS2(3), RBKS(3), RPE(5), RPIA(2), TALDO1(5), TKT(4), TKTL1(10), TKTL2(12)	10417105	125	57	119	39	31	38	6	21	29	0	0.157	1.000	1.000
487	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(6), DCXR(1), GUSB(11), RPE(5), UGDH(5), UGP2(7), UGT1A1(4), UGT1A10(1), UGT1A3(1), UGT1A4(3), UGT1A5(3), UGT1A6(6), UGT1A7(3), UGT1A9(3), UGT2A1(3), UGT2A3(6), UGT2B10(5), UGT2B11(1), UGT2B15(3), UGT2B17(2), UGT2B28(7), UGT2B4(4), UGT2B7(6), XYLB(7)	11603295	103	57	100	26	17	31	3	27	25	0	0.160	1.000	1.000
488	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(3), CAT(5), EPX(9), LPO(9), MPO(7), PRDX1(1), PRDX2(2), PRDX5(1), PRDX6(2), SHMT1(2), SHMT2(9), TPO(24)	5046162	74	57	72	25	23	10	5	18	17	1	0.543	1.000	1.000
489	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(4), BLVRA(4), BLVRB(1), CP(10), CPOX(2), EPRS(11), FECH(6), GUSB(11), HCCS(3), HMBS(3), HMOX1(5), HMOX2(1), PPOX(5), UGT1A1(4), UGT1A10(1), UGT1A3(1), UGT1A4(3), UGT1A5(3), UGT1A6(6), UGT1A7(3), UGT1A9(3), UGT2B15(3), UGT2B4(4), UROD(1), UROS(4)	11715149	102	56	102	36	23	31	2	24	22	0	0.581	1.000	1.000
490	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	12	AKT1(3), BAD(3), CHRNB1(4), CHRNG(4), MUSK(13), PIK3R1(11), PTK2(11), PTK2B(16), RAPSN(4), SRC(3), TERT(4), YWHAH(3)	6077439	79	55	78	28	26	16	5	14	17	1	0.528	1.000	1.000
491	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(6), AKR1D1(3), ARSB(2), ARSD(4), ARSE(5), CYP11B1(12), CYP11B2(5), HSD11B1(3), HSD11B2(3), HSD17B2(2), HSD17B3(1), HSD3B1(4), HSD3B2(1), SRD5A1(3), STS(6), SULT1E1(2), SULT2A1(3), UGT1A1(4), UGT1A10(1), UGT1A3(1), UGT1A4(3), UGT1A5(3), UGT1A6(6), UGT1A7(3), UGT1A9(3), UGT2B15(3), UGT2B4(4)	11676971	96	55	95	36	29	36	3	15	13	0	0.392	1.000	1.000
492	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	B3GNT1(3), B3GNT2(3), B3GNT3(5), B3GNT4(7), B3GNT5(10), B4GALT1(2), B4GALT2(7), B4GALT3(2), B4GALT4(5), FUT1(3), FUT2(1), FUT3(3), FUT4(2), FUT5(3), FUT6(4), FUT7(2), FUT9(6), GCNT2(2), ST3GAL6(4), ST8SIA1(7)	6941063	81	55	76	28	25	19	3	13	21	0	0.647	1.000	1.000
493	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	17	DNAJA3(4), HSPA1A(2), IFNG(2), IFNGR1(6), IFNGR2(2), IKBKB(8), JAK2(13), LIN7A(9), NFKB1(7), NFKBIA(1), RB1(13), RELA(5), TNF(3), TNFRSF1A(6), TNFRSF1B(3), USH1C(4), WT1(3)	7437068	91	55	88	33	18	24	1	23	24	1	0.657	1.000	1.000
494	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QA(5), C1QB(1), C1R(5), C1S(7), C2(1), C3(30), C5(11), C6(12), C7(3), C8A(5), C8B(14), C9(7), MASP1(1)	8920652	102	54	93	28	30	20	3	22	26	1	0.284	1.000	1.000
495	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	14	AKT1(3), BAD(3), GRB2(4), IGF1R(16), IRS1(24), MAP2K1(5), MAPK1(3), MAPK3(1), PIK3R1(11), RAF1(10), SHC1(7), SOS1(7), YWHAH(3)	7208112	97	54	92	31	28	27	2	13	25	2	0.417	1.000	1.000
496	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(5), ICAM1(2), ITGA4(12), ITGAL(16), ITGAM(9), ITGB1(10), ITGB2(6), SELE(5), SELL(4), SELP(10)	6840070	79	54	75	39	29	15	1	19	15	0	0.890	1.000	1.000
497	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(1), ALDOB(6), ALDOC(6), FBP1(4), FBP2(5), G6PD(5), GPI(5), H6PD(6), PFKM(2), PFKP(14), PGD(6), PGLS(2), PGM1(2), PGM3(7), PRPS1(3), PRPS1L1(2), PRPS2(3), RBKS(3), RPE(5), RPIA(2), TAL1(5), TALDO1(5), TKT(4)	8776582	103	54	98	32	24	30	4	18	27	0	0.215	1.000	1.000
498	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	CISH(3), IL6R(2), JAK1(12), JAK2(13), JAK3(13), PIAS3(7), PTPRU(25), REG1A(4), SRC(3), STAT3(7)	6536837	89	54	85	30	24	23	0	17	24	1	0.602	1.000	1.000
499	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARF1(5), ARFGAP1(2), ARFGAP3(5), ARFGEF2(28), CLTA(2), CLTB(1), COPA(9), GBF1(18), GPLD1(11), KDELR1(2), KDELR2(1), KDELR3(3)	6976993	87	53	86	26	27	29	1	13	17	0	0.165	1.000	1.000
500	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	20	APAF1(8), ARHGDIB(1), BIRC2(3), BIRC3(6), CASP1(4), CASP10(6), CASP2(3), CASP3(2), CASP4(8), CASP6(1), CASP7(3), CASP9(3), DFFA(4), DFFB(3), GZMB(3), LMNA(6), LMNB1(4), LMNB2(6), PRF1(8)	7772192	82	53	79	23	21	19	5	14	23	0	0.357	1.000	1.000
501	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(5), AMD1(5), BHMT(5), CBS(6), CTH(2), DNMT1(13), DNMT3A(8), DNMT3B(15), MARS(4), MARS2(2), MAT1A(4), MAT2B(3), MTAP(1), MTFMT(1), MTR(13), SRM(1), TAT(5)	8894699	93	53	90	49	28	29	2	16	18	0	0.964	1.000	1.000
502	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(11), AMT(4), ATIC(6), GART(9), MTHFD1(5), MTHFD1L(6), MTHFD2(1), MTHFR(9), MTHFS(3), MTR(13), SHMT1(2), SHMT2(9), TYMS(1)	7669366	79	53	76	25	21	18	3	12	24	1	0.216	1.000	1.000
503	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(4), DUSP1(2), IKBKAP(14), IKBKB(8), LTA(4), MAP3K1(11), NFKB1(7), NFKBIA(1), RELA(5), RIPK1(2), TANK(3), TNFAIP3(10), TNFRSF1B(3), TRAF1(3), TRAF2(4), TRAF3(4)	9635897	85	53	82	28	24	15	3	14	28	1	0.595	1.000	1.000
504	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOA(1), ALDOB(6), ALDOC(6), FBP1(4), FBP2(5), GOT1(3), GOT2(2), GPT(3), GPT2(5), MDH1(3), ME1(2), ME2(5), ME3(4), PGK1(4), PKLR(7), RPE(5), RPIA(2), TKT(4), TPI1(1)	7747581	72	52	72	29	21	21	2	15	13	0	0.635	1.000	1.000
505	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QA(5), C1QB(1), C1R(5), C1S(7), C2(1), C3(30), C5(11), C6(12), C7(3), C8A(5), C9(7), MASP1(1), MASP2(6), MBL2(4)	9135788	98	52	89	30	29	20	3	16	29	1	0.455	1.000	1.000
506	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(10), EGFR(15), MAP2K1(5), MAP3K1(11), MAPK14(1), NCOR2(30), RARA(3), RXRA(6), THRA(6), THRB(9)	7391765	96	52	89	40	39	20	2	15	20	0	0.776	1.000	1.000
507	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT1(5), ACAT2(4), ACOT11(6), ACYP1(1), ACYP2(3), DHRS1(2), DHRS3(2), DHRS7(6), DHRSX(5), EHHADH(7), ESCO1(7), ESCO2(8), FN3K(3), GCDH(8), HADHA(4), NAT6(3), PNPLA3(2), SH3GLB1(3), YOD1(2)	11150538	81	51	77	17	19	25	3	7	25	2	0.0525	1.000	1.000
508	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(8), CLOCK(5), CRY1(3), CRY2(5), CSNK1D(2), CSNK1E(8), NPAS2(11), NR1D1(5), PER1(4), PER2(15), PER3(12)	7294432	78	51	76	25	22	15	5	18	17	1	0.370	1.000	1.000
509	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(2), ALG5(3), B4GALT1(2), B4GALT2(7), B4GALT3(2), B4GALT5(6), DPAGT1(4), DPM1(1), FUT8(7), MAN1A1(2), MAN1B1(6), MGAT1(3), MGAT2(2), MGAT3(8), MGAT4A(5), MGAT4B(3), MGAT5(10), RPN1(3), RPN2(6)	8554570	82	51	80	42	24	18	4	17	19	0	0.975	1.000	1.000
510	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(6), FUCA1(1), FUCA2(2), GLB1(5), HEXA(2), HEXB(3), LCT(23), MAN2C1(11), MANBA(7), NEU1(3), NEU2(6), NEU3(5), NEU4(2)	7079699	76	51	76	27	23	16	3	13	21	0	0.670	1.000	1.000
511	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(9), ESR2(9), ITPKA(2), PDE1A(7), PDE1B(6), PLCB1(19), PLCB2(8), PRL(1), TRH(4), VIP(5)	4767984	70	51	67	25	23	14	4	15	14	0	0.604	1.000	1.000
512	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	14	AKT1(3), AKT2(8), AKT3(6), BPNT1(4), GRB2(4), ILK(8), MAPK1(3), MAPK3(1), PDK1(3), PIK3CD(11), PTK2B(16), RBL2(8), SHC1(7), SOS1(7)	7470757	89	51	86	23	34	20	0	13	21	1	0.272	1.000	1.000
513	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	14	AKT1(3), AKT2(8), AKT3(6), CDKN1A(3), ELK1(3), GRB2(4), MAP2K1(5), MAP2K2(3), NGFR(4), NTRK1(10), PIK3CD(11), SHC1(7), SOS1(7)	5976990	74	51	71	29	28	18	1	17	10	0	0.636	1.000	1.000
514	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(9), LPO(9), MPO(7), PRDX1(1), PRDX2(2), PRDX5(1), PRDX6(2), TPO(24), TYR(9)	4127047	64	51	62	24	18	12	5	19	9	1	0.678	1.000	1.000
515	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	13	ABL1(7), E2F1(3), MDM2(5), MYC(5), PIK3R1(11), POLR1A(15), POLR1B(8), POLR1C(3), POLR1D(4), RB1(13), TBX2(6), TWIST1(2)	7159385	82	50	78	30	21	22	1	10	27	1	0.633	1.000	1.000
516	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	15	ADAM12(6), AGT(3), AGTR2(4), EDN1(3), EDNRA(4), EGF(10), EGFR(15), FOS(1), JUN(4), MYC(5), NFKB1(7), PLCG1(19), PRKCA(5), RELA(5)	8444319	91	50	89	32	26	18	7	21	19	0	0.474	1.000	1.000
517	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	21	CCNA1(6), CCNB1(3), CCND1(1), CCND2(3), CCND3(2), CCNE1(5), CCNH(2), CDC25A(6), CDK2(3), CDK6(4), CDKN1A(3), CDKN2D(3), E2F1(3), RB1(13), RBL1(11), TFDP1(5)	6638746	73	50	70	28	14	27	2	15	15	0	0.611	1.000	1.000
518	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	27	CCL3(1), CCR1(5), CCR2(6), CCR3(6), CCR5(4), CCR7(3), CD28(1), CXCR3(1), CXCR4(1), IFNG(2), IFNGR1(6), IFNGR2(2), IL12A(2), IL12B(2), IL12RB1(5), IL12RB2(11), IL18R1(4), IL4(1), IL4R(3), TGFB1(3), TGFB2(6), TGFB3(8)	8207664	83	50	83	32	20	19	3	21	19	1	0.643	1.000	1.000
519	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	CNR1(11), DNMT1(13), MTNR1A(5), MTNR1B(6), PTAFR(5), PTGDR(7), PTGER2(5), PTGER4(8), PTGFR(5), TBXA2R(8)	4774797	73	50	71	39	30	20	4	14	5	0	0.834	1.000	1.000
520	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QA(5), C1QB(1), C1R(5), C1S(7), C2(1), C3(30), C5(11), C6(12), C7(3), C8A(5), C9(7)	7502145	87	49	79	28	26	18	3	16	23	1	0.565	1.000	1.000
521	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(2), GALNS(1), GLB1(5), GNS(5), GUSB(11), HEXA(2), HEXB(3), IDS(4), IDUA(4), LCT(23), NAGLU(6)	6152305	66	49	66	29	20	18	1	13	14	0	0.806	1.000	1.000
522	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	21	AKT1(3), CCND1(1), CCNE1(5), CDK2(3), CDK6(4), CDKN1A(3), E2F1(3), MAPK1(3), MAPK3(1), NFKB1(7), NFKBIA(1), PAK1(5), PIK3R1(11), RAF1(10), RB1(13), RELA(5), TFDP1(5)	7743062	83	49	80	21	16	28	2	13	23	1	0.113	1.000	1.000
523	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP1(5), ACP2(4), ACP5(2), ACP6(3), ACPP(3), ACPT(4), ALPI(6), ALPL(8), ALPP(7), ALPPL2(5), CYP3A4(4), CYP3A43(4), CYP3A7(4), DHRS1(2), DHRS3(2), DHRS7(6), DHRSX(5), PON1(2), PON2(3), PON3(2)	7742962	81	48	77	39	30	17	1	12	20	1	0.913	1.000	1.000
524	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(3), ALDH18A1(7), ARG1(2), ARG2(2), ASL(6), CKB(2), CKM(1), CKMT1A(3), CKMT1B(1), CKMT2(6), CPS1(22), GAMT(1), GATM(3), GLUD1(2), NAGS(1), OAT(2), ODC1(4), OTC(2), PYCR1(1), SMS(5)	7505559	76	48	76	22	24	20	3	21	8	0	0.149	1.000	1.000
525	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(3), ACTR2(2), ACTR3(2), ARPC1A(3), ARPC2(3), ARPC4(2), NCK1(6), NCKAP1(9), NTRK1(10), PIR(1), PSMA7(4), WASF1(5), WASF2(5), WASF3(13), WASL(3)	6535402	71	47	67	30	24	17	2	9	18	1	0.804	1.000	1.000
526	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(4), DUSP1(2), IKBKAP(14), IKBKB(8), MAP3K1(11), NFKB1(7), NFKBIA(1), RELA(5), TNFAIP3(10), TRAF3(4), TRAF6(6)	7779939	72	47	69	19	20	12	2	12	26	0	0.373	1.000	1.000
527	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(9), FOS(1), GRB2(4), IL3(1), IL3RA(5), JAK2(13), MAP2K1(5), MAPK3(1), PTPN6(4), RAF1(10), SHC1(7), SOS1(7), STAT5A(3), STAT5B(14)	7591736	84	47	78	28	23	26	1	17	16	1	0.466	1.000	1.000
528	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	66	MRPL13(1), MRPS7(1), RPL10A(2), RPL11(1), RPL12(3), RPL13A(4), RPL14(1), RPL18(1), RPL19(2), RPL22L1(1), RPL23A(2), RPL24(1), RPL26(1), RPL27(1), RPL28(2), RPL29(1), RPL3(3), RPL31(1), RPL34(2), RPL35A(1), RPL36A(1), RPL37(1), RPL38(1), RPL3L(3), RPL6(2), RPL7(1), RPL8(2), RPL9(3), RPS11(2), RPS13(2), RPS18(1), RPS20(1), RPS23(1), RPS24(1), RPS25(1), RPS27(1), RPS3(2), RPS3A(2), RPS4Y1(1), RPS5(4), RPS6(1), RPS7(1), RPS9(1), RPSA(2)	9510507	70	46	68	27	17	23	2	10	18	0	0.799	1.000	1.000
529	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CCR5(4), CD3E(2), CD3G(1), CXCR3(1), ETV5(5), IFNG(2), IL12A(2), IL12B(2), IL12RB1(5), IL12RB2(11), IL18(1), IL18R1(4), JAK2(13), JUN(4), MAP2K6(1), MAPK14(1), MAPK8(5), STAT4(6), TYK2(9)	7995959	79	46	79	30	10	23	5	16	22	3	0.749	1.000	1.000
530	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(3), GRB2(4), IL2RG(6), IL4(1), IL4R(3), IRS1(24), JAK1(12), JAK3(13), RPS6KB1(5), SHC1(7), STAT6(3)	6338702	81	46	75	24	22	20	1	7	30	1	0.612	1.000	1.000
531	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(5), BHMT(5), CBS(6), CTH(2), DNMT1(13), DNMT3A(8), DNMT3B(15), MARS(4), MARS2(2), MAT1A(4), MAT2B(3), MTR(13)	7458581	80	46	77	43	26	23	2	12	17	0	0.959	1.000	1.000
532	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	12	AOX1(12), CD38(4), ENPP1(7), ENPP3(8), NADSYN1(8), NMNAT1(3), NMNAT2(1), NNMT(1), NNT(12), NT5C(1), NT5E(2)	6080969	59	46	57	27	7	15	4	15	17	1	0.928	1.000	1.000
533	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	6	AKT1(3), PIK3R1(11), PLCB1(19), PLCG1(19), PRKCA(5), VAV1(9)	4574941	66	46	63	20	19	16	2	8	20	1	0.419	1.000	1.000
534	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	5	ATM(38), ATR(18), CHEK1(4), CHEK2(8), YWHAH(3)	6076602	71	46	66	19	15	15	1	14	23	3	0.702	1.000	1.000
535	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(3), FUT1(3), FUT2(1), FUT9(6), GBGT1(3), GLA(3), HEXA(2), HEXB(3), NAGA(5), ST3GAL1(4), ST3GAL2(6), ST3GAL4(6), ST8SIA1(7)	4353526	52	44	50	20	26	7	1	12	6	0	0.566	1.000	1.000
536	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(4), HK1(16), HK2(10), HK3(6), IMPA1(4), IMPA2(2), ISYNA1(3), PGM1(2), PGM3(7), TGDS(4)	5006454	58	44	57	25	21	20	2	11	4	0	0.507	1.000	1.000
537	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(10), CD44(5), CSF1(2), FCGR3A(4), IL1B(3), IL6R(2), SELL(4), SPN(4), TGFB1(3), TGFB2(6), TNF(3), TNFRSF1A(6), TNFRSF1B(3), TNFRSF8(4), TNFSF8(3)	5649037	62	44	61	30	20	14	0	12	15	1	0.865	1.000	1.000
538	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	ALDOA(1), CTSD(7), ESR1(9), GREB1(22), HSPB2(1), MTA1(8), MTA3(2), PDZK1(2), TUBA8(5)	4688945	57	43	55	24	21	17	3	5	11	0	0.593	1.000	1.000
539	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(3), CD28(1), CD3E(2), CD3G(1), CD8A(4), ICAM1(2), ITGAL(16), ITGB2(6), PTPRC(19), THY1(1)	4615326	55	43	52	25	13	16	2	14	10	0	0.817	1.000	1.000
540	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(3), B3GALNT1(3), B3GALT5(1), FUT1(3), FUT2(1), FUT9(6), GBGT1(3), GLA(3), HEXA(2), HEXB(3), NAGA(5), ST3GAL1(4), ST3GAL2(6), ST8SIA1(7)	4620674	50	42	48	23	23	6	2	12	7	0	0.806	1.000	1.000
541	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACAA1(3), ACOX1(5), ACOX3(11), ELOVL2(7), ELOVL5(2), ELOVL6(1), FADS1(3), FADS2(5), FASN(19), HADHA(4), HSD17B12(3), PECR(1), SCD(1)	6118413	65	42	59	28	24	12	5	8	16	0	0.779	1.000	1.000
542	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(4), BLVRB(1), HMOX1(5), IL10(2), IL10RA(5), IL10RB(3), IL1A(2), JAK1(12), STAT1(10), STAT3(7), STAT5A(3), TNF(3)	5236591	57	42	57	19	11	16	0	15	15	0	0.556	1.000	1.000
543	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	9	CD3E(2), CD3G(1), FYN(10), HLA-DRA(8), LCK(4), PTPRC(19), ZAP70(14)	3489064	58	42	56	22	18	20	1	13	6	0	0.566	1.000	1.000
544	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(13), EGF(10), EGFR(15), HGS(4), RAB5A(2), TF(15), TFRC(2)	5503496	61	41	58	27	16	12	2	16	13	2	0.872	1.000	1.000
545	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	23	CYP27B1(5), CYP51A1(8), DHCR24(4), DHCR7(6), EBP(1), FDFT1(2), FDPS(9), GGCX(4), GGPS1(1), HMGCR(7), HSD17B7(3), IDI1(2), IDI2(1), LSS(9), MVD(2), NQO1(3), NSDHL(3), PMVK(1), SQLE(5), TM7SF2(2), VKORC1(1)	7905200	79	41	75	25	21	17	2	17	21	1	0.548	1.000	1.000
546	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	ADAM17(6), DLL1(15), FURIN(5), NOTCH1(26), PSEN1(3)	3968173	55	41	53	28	20	10	4	11	10	0	0.826	1.000	1.000
547	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(8), POLR2A(19), POLR2B(11), POLR2C(4), POLR2E(2), POLR2F(4), POLR2G(1), POLR2I(2), POLR2K(1), POLRMT(9)	5766212	61	41	60	18	20	20	0	11	10	0	0.172	1.000	1.000
548	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(4), HK1(16), HK2(10), HK3(6), IMPA1(4), PGM1(2), PGM3(7), TGDS(4)	4393173	53	41	53	22	18	20	2	9	4	0	0.484	1.000	1.000
549	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	6	ADCY1(19), CREM(4), FHL5(3), FSHB(1), GNAS(29), XPO1(7)	3521065	63	40	59	23	30	13	0	15	5	0	0.779	1.000	1.000
550	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(6), DCXR(1), GUSB(11), RPE(5), UCHL1(1), UCHL3(3), UGDH(5), UGT1A1(4), UGT1A10(1), UGT1A3(1), UGT1A4(3), UGT1A5(3), UGT1A6(6), UGT1A7(3), UGT1A9(3), UGT2B15(3), UGT2B4(4)	7488405	63	40	63	19	16	21	1	14	11	0	0.245	1.000	1.000
551	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(12), JAK2(13), JAK3(13), MAPK1(3), MAPK3(1), STAT3(7), TYK2(9)	5011880	58	40	57	22	12	20	0	12	13	1	0.729	1.000	1.000
552	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	10	CD2(3), CD28(1), CD3E(2), CD3G(1), ICAM1(2), ITGAL(16), ITGB2(6), PTPRC(19), THY1(1)	4453020	51	40	48	25	12	15	1	13	10	0	0.895	1.000	1.000
553	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(19), GNAS(29), GNB1(1), GNGT1(3), PRKACA(4), PRKAR1A(3)	2861889	59	39	56	22	30	10	0	11	8	0	0.725	1.000	1.000
554	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(5), ICAM1(2), ITGA4(12), ITGAL(16), ITGB1(10), ITGB2(6), SELE(5), SELL(4)	5201509	60	39	56	29	22	14	1	12	11	0	0.770	1.000	1.000
555	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(11), CHAT(4), CHKA(2), PCYT1A(9), PDHA1(1), PDHA2(6), PEMT(1), SLC18A3(13)	2990888	47	38	47	26	18	10	0	14	5	0	0.914	1.000	1.000
556	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	12	AKT1(3), CAT(5), GH1(2), GHR(6), IGF1(4), IGF1R(16), PIK3R1(11), SHC1(7), SOD2(1)	4771973	55	38	54	20	10	17	2	13	12	1	0.640	1.000	1.000
557	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(3), PSMA2(1), PSMA3(3), PSMA4(4), PSMA6(5), PSMA7(4), PSMB1(2), PSMB2(2), PSMB3(2), PSMB4(3), PSMB5(1), PSMB6(3), PSMC3(8), PSMD14(1), RPN1(3), RPN2(6), UBE2A(1), UBE3A(5)	5531848	57	38	56	21	15	17	5	9	11	0	0.541	1.000	1.000
558	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(1), RANBP1(1), RANBP2(33), RANGAP1(12)	3622899	47	38	47	19	6	15	3	10	11	2	0.791	1.000	1.000
559	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(6), AKR1D1(3), CYP11A1(5), CYP11B1(12), CYP11B2(5), CYP17A1(6), CYP21A2(5), HSD11B1(3), HSD11B2(3), HSD3B1(4), HSD3B2(1)	3982377	53	37	52	18	20	15	4	9	5	0	0.358	1.000	1.000
560	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(6), AKR1D1(3), CYP11A1(5), CYP11B1(12), CYP11B2(5), CYP17A1(6), CYP21A2(5), HSD11B1(3), HSD11B2(3), HSD3B1(4), HSD3B2(1)	3982377	53	37	52	18	20	15	4	9	5	0	0.358	1.000	1.000
561	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	14	CCR5(4), CD2(3), CD3E(2), CD3G(1), CXCR3(1), IFNG(2), IL12A(2), IL12B(2), IL12RB1(5), IL12RB2(11), JAK2(13), STAT4(6), TYK2(9)	5910953	61	37	61	27	7	19	4	13	16	2	0.892	1.000	1.000
562	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(10), AGT(3), AGTR1(2), AGTR2(4), BDKRB2(4), KNG1(9), NOS3(10), REN(4)	4226077	46	36	43	17	12	9	3	6	15	1	0.636	1.000	1.000
563	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	14	CYP51A1(8), DHCR7(6), FDFT1(2), FDPS(9), HMGCR(7), HMGCS1(2), IDI1(2), LSS(9), MVD(2), NSDHL(3), PMVK(1), SQLE(5)	5286772	56	36	53	19	15	10	1	14	16	0	0.624	1.000	1.000
564	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(5), CBS(6), CTH(2), GGT1(6), MARS(4), MARS2(2), MAT1A(4), MAT2B(3), PAPSS1(6), PAPSS2(5), SCLY(2), SEPHS1(4)	5307074	49	36	47	23	16	10	2	7	14	0	0.819	1.000	1.000
565	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(2), IL13RA1(4), IL13RA2(6), IL4R(3), JAK1(12), JAK2(13), TYK2(9)	4493030	49	36	49	22	10	15	2	8	13	1	0.895	1.000	1.000
566	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(2), IL13RA1(4), IL13RA2(6), IL4R(3), JAK1(12), JAK2(13), TYK2(9)	4493030	49	36	49	22	10	15	2	8	13	1	0.895	1.000	1.000
567	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(5), CYP2A13(8), CYP2A6(7), CYP2A7(3), NAT1(2), NAT2(5), XDH(14)	3428046	44	35	44	16	11	14	1	13	5	0	0.570	1.000	1.000
568	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(8), ACO2(9), AFMID(3), CS(3), GRHPR(1), HAO1(3), HAO2(5), HYI(2), MDH1(3), MTHFD1(5), MTHFD1L(6), MTHFD2(1)	5751981	49	35	48	21	19	17	2	4	7	0	0.587	1.000	1.000
569	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(5), ICAM1(2), ITGAL(16), ITGAM(9), ITGB2(6), SELE(5), SELL(4)	4455983	47	35	46	30	18	10	1	8	10	0	0.985	1.000	1.000
570	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(9), CAPN1(5), CAPNS1(2), CAPNS2(2), CDK5(2), CDK5R1(4), CSNK1A1(3), CSNK1D(2), GSK3B(5), MAPT(7), PPP2CA(4)	3947928	45	35	44	24	17	14	0	7	6	1	0.914	1.000	1.000
571	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	4	EGF(10), EGFR(15), NRG1(14)	3214486	39	34	38	21	14	11	3	6	5	0	0.868	1.000	1.000
572	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(8), ACO2(9), CS(3), GRHPR(1), HAO1(3), HAO2(5), HYI(2), MDH1(3), MTHFD1(5), MTHFD1L(6), MTHFD2(1)	5492669	46	34	45	21	17	16	2	4	7	0	0.696	1.000	1.000
573	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(5), CARS2(6), CDO1(1), CTH(2), GOT1(3), GOT2(2), LDHA(3), LDHAL6B(5), LDHB(4), LDHC(1), MPST(2), SDS(4), SULT1B1(4), SULT1C2(2), SULT1C4(2), SULT4A1(2)	5375393	48	34	48	19	17	14	1	8	8	0	0.619	1.000	1.000
574	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	AKR1B10(6), DHRS1(2), DHRS3(2), DHRS7(6), DHRSX(5), HSD3B7(6), PON1(2), PON2(3), PON3(2), RDH11(1), RDH12(3), RDH13(5)	3863797	43	34	42	22	15	11	2	9	5	1	0.909	1.000	1.000
575	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(3), ANKRD1(5), ATF3(1), CYR61(1), DUSP14(3), EIF4E(2), EIF4EBP1(2), HBEGF(1), IFNG(2), IFRD1(8), IL18(1), IL1A(2), IL1R1(4), JUND(2), MYOG(4), NR4A3(5), WDR1(2)	4571364	48	34	45	17	17	6	4	10	11	0	0.597	1.000	1.000
576	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(9), CS(3), FH(3), IDH2(4), MDH1(3), OGDH(11), SDHA(6), SUCLA2(4)	4045241	43	34	40	17	14	10	2	4	11	2	0.763	1.000	1.000
577	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	8	CD3E(2), CD3G(1), GZMB(3), ICAM1(2), ITGAL(16), ITGB2(6), PRF1(8)	3328004	38	33	37	16	13	8	1	6	10	0	0.694	1.000	1.000
578	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(5), ADSS(5), IMPDH1(5), MTHFD2(1), NME2(3), POLB(4), POLD1(15), POLG(8), PRPS2(3), RRM1(5), SRM(1)	5356739	55	33	55	19	19	16	2	8	10	0	0.466	1.000	1.000
579	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	MMP14(6), MMP2(6), MMP9(17), RECK(8), TIMP2(2), TIMP3(6), TIMP4(1)	3229191	46	33	45	21	18	11	0	4	12	1	0.798	1.000	1.000
580	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(3), APAF1(8), BCL2(3), CASP3(2), CASP9(3), DAXX(10), FAS(3), FASLG(3), HSPB2(1), IL1A(2), MAPKAPK2(1), MAPKAPK3(5), TNF(3)	4861076	47	32	46	23	15	9	0	12	10	1	0.924	1.000	1.000
581	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(4), GNAQ(4), GNB1(1), GNGT1(3), HTR2C(6), PLCB1(19), TUB(5)	3071122	42	32	41	18	12	8	1	9	12	0	0.826	1.000	1.000
582	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	CDK5(2), CDK5R1(4), EGR1(10), KLK2(1), MAP2K1(5), MAP2K2(3), MAPK1(3), MAPK3(1), NGFR(4), RAF1(10)	3504293	43	31	38	19	14	12	0	8	9	0	0.724	1.000	1.000
583	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(2), IFNGR1(6), IFNGR2(2), JAK1(12), JAK2(13), STAT1(10)	3519636	45	31	45	17	6	15	1	8	14	1	0.774	1.000	1.000
584	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(5), IARS(10), LARS(5), LARS2(8), PDHA1(1), PDHA2(6), PDHB(4)	4295125	39	31	39	17	6	13	1	10	9	0	0.865	1.000	1.000
585	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNA1(1), IFNB1(3), IFNG(2), IL10(2), IL12A(2), IL12B(2), IL13(2), IL16(13), IL18(1), IL1A(2), IL3(1), IL4(1), LTA(4), TNF(3)	4262673	39	30	39	20	8	10	2	10	9	0	0.948	1.000	1.000
586	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(6), ALPL(8), ALPP(7), ALPPL2(5), FPGS(4), GCH1(1), GGH(3), SPR(2)	2800342	36	30	35	17	21	4	0	5	6	0	0.585	1.000	1.000
587	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	B3GALT1(3), B3GALT2(7), B3GALT5(1), B3GNT5(10), FUT1(3), FUT2(1), FUT3(3), ST3GAL3(2), ST3GAL4(6)	3103013	36	30	33	15	15	5	0	4	12	0	0.877	1.000	1.000
588	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(6), GAD1(7), HDC(8), PNMT(8), TH(3), TPH1(3)	2587177	35	30	34	17	14	7	2	5	6	1	0.815	1.000	1.000
589	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	13	ACTR2(2), ACTR3(2), ARPC1A(3), ARPC2(3), ARPC4(2), CDC42(1), PAK1(5), PDGFRA(11), PIK3R1(11), WASL(3)	4806501	43	29	42	19	4	17	1	6	14	1	0.894	1.000	1.000
590	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(9), CKM(1), EIF4E(2), FBL(5), GPT(3), LDHA(3), LDHB(4), LDHC(1), MAPK14(1), NCL(7)	3852606	36	29	35	15	7	9	0	11	9	0	0.907	1.000	1.000
591	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(5), CYP2E1(6), NR1I3(4), PTGS1(12), PTGS2(7)	2297060	34	27	34	13	12	9	1	5	7	0	0.654	1.000	1.000
592	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(7), FARSA(3), FARSB(1), GOT1(3), GOT2(2), PAH(6), TAT(5), YARS(6), YARS2(2)	3735417	35	27	35	13	10	11	0	8	6	0	0.656	1.000	1.000
593	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(9), CS(3), MDH1(3), ME1(2), PC(15), PDHA1(1), SLC25A1(1), SLC25A11(2)	3977681	36	27	35	15	13	9	2	5	7	0	0.742	1.000	1.000
594	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	12	CCNA1(6), CCNA2(1), CCND1(1), CCNE1(5), CCNE2(3), CDK2(3), E2F1(3), E2F2(4), PRB1(4)	3596037	30	27	30	14	5	14	1	6	4	0	0.718	1.000	1.000
595	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	FABP6(3), LDLR(10), NR0B2(3), NR1H3(6), NR1H4(5), RXRA(6)	2341435	33	26	31	15	15	4	0	5	9	0	0.732	1.000	1.000
596	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(5), ACAT2(4), BDH1(5), HMGCS1(2), HMGCS2(3), OXCT1(8), OXCT2(3)	3087523	30	26	30	13	8	8	1	6	6	1	0.842	1.000	1.000
597	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	CDC34(2), NRF1(6), TAX1BP3(1), UBE2A(1), UBE2D3(1), UBE2E3(3), UBE2G2(2), UBE2H(1), UBE2I(1), UBE2J1(1), UBE2J2(6), UBE2L3(1), UBE2L6(1), UBE2M(1), UBE2N(1), UBE2S(1), UBE3A(5)	4508860	35	26	35	16	15	9	0	3	8	0	0.634	1.000	1.000
598	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(5), CYP11A1(5), CYP11B2(5), CYP17A1(6), HSD11B1(3), HSD11B2(3), HSD3B1(4), HSD3B2(1)	2971693	32	25	32	14	10	6	5	6	5	0	0.745	1.000	1.000
599	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(5), ADORA2A(1), ADORA2B(1), ADORA3(5), LTB4R(2), P2RY1(3), P2RY2(5), P2RY6(8)	2559650	30	25	30	12	16	3	1	6	3	1	0.489	1.000	1.000
600	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(8), CLOCK(5), CRY1(3), CRY2(5), CSNK1E(8), PER1(4)	3629150	33	24	32	15	10	7	2	5	8	1	0.895	1.000	1.000
601	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	9	BAG4(2), BIRC3(6), FADD(1), RIPK1(2), TNF(3), TNFRSF1A(6), TNFRSF1B(3), TRADD(2), TRAF2(4)	3080991	29	24	29	14	7	7	1	4	9	1	0.899	1.000	1.000
602	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	6	HDAC1(5), MAX(3), MYC(5), SP1(6), SP3(3), WT1(3)	2677771	25	23	25	14	6	8	0	6	5	0	0.895	1.000	1.000
603	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(6), EPHX2(4), HSD3B7(6), RDH11(1), RDH12(3), RDH13(5)	2060797	25	22	24	13	8	8	1	4	4	0	0.865	1.000	1.000
604	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(5), PLCD1(4), PRKCA(5), TGM2(12)	2138229	26	22	26	10	14	3	0	5	4	0	0.533	1.000	1.000
605	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(6), CDC25B(4), CDKN1A(3), CHEK1(4), NEK1(4), WEE1(4)	2941216	25	22	25	10	5	9	0	6	5	0	0.852	1.000	1.000
606	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(5), AASDH(7), AASDHPPT(1), AASS(7), KARS(5)	2983556	25	21	25	10	5	10	1	5	4	0	0.705	1.000	1.000
607	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	B3GNT1(3), FUT1(3), FUT2(1), FUT9(6), GCNT2(2), ST8SIA1(7)	2635353	22	20	21	10	8	3	1	8	2	0	0.777	1.000	1.000
608	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(2), GPD2(7), NDUFA1(1), SDHA(6), SDHB(4), SDHC(1), SDHD(1), UQCRC1(2)	2840593	24	19	24	10	9	6	2	4	3	0	0.590	1.000	1.000
609	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(3), ACTR2(2), ACTR3(2), ARPC1A(3), ARPC2(3), ARPC4(2), CDC42(1), WASF1(5), WASL(3)	3482292	24	19	24	20	5	7	1	3	8	0	0.999	1.000	1.000
610	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(5), CTH(2), GOT1(3), GOT2(2), LDHA(3), LDHB(4), LDHC(1), MPST(2)	2935234	22	18	22	10	7	8	1	2	4	0	0.754	1.000	1.000
611	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	4	GOT1(3), GOT2(2), TAT(5), TYR(9)	1590256	19	18	18	11	4	6	1	6	2	0	0.931	1.000	1.000
612	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	FUT1(3), FUT2(1), FUT3(3), FUT5(3), FUT6(4), ST3GAL3(2)	2191676	16	13	16	10	9	3	0	1	3	0	0.893	1.000	1.000
613	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(3), RAB11A(4), RAB27A(4), RAB4A(2), RAB5A(2), RAB6A(1)	1819759	16	11	16	13	4	5	0	2	5	0	0.967	1.000	1.000
614	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(5), PGLYRP2(3)	778402	8	7	8	6	4	3	0	1	0	0	0.917	1.000	1.000
615	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(7)	870608	7	5	7	3	3	2	0	2	0	0	0.736	1.000	1.000
616	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		218932	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
