rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	AKT1(4), EIF4A1(5), EIF4A2(8), EIF4B(7), EIF4E(1), EIF4G1(16), EIF4G2(7), EIF4G3(23), FKBP1A(1), MKNK1(3), PDK2(4), PDPK1(3), PIK3CA(172), PIK3R1(99), PPP2CA(6), PTEN(227), RPS6(7), RPS6KB1(3), TSC1(12), TSC2(14)	9925342	622	218	409	44	89	126	123	38	202	44	<1.00e-15	<1.00e-15	<3.87e-14
2	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	26	AKT1(4), APC(56), AXIN1(9), CCND1(14), CD14(2), CTNNB1(80), DVL1(3), FZD1(3), GJA1(5), GNAI1(5), GSK3B(13), IRAK1(4), LBP(3), LEF1(8), LY96(4), MYD88(2), NFKB1(10), PDPK1(3), PIK3CA(172), PIK3R1(99), PPP2CA(6), RELA(6), TIRAP(2), TLR4(17), TOLLIP(1), WNT1(1)	10634125	532	210	352	57	77	194	121	6	115	19	1.24e-13	<1.00e-15	<3.87e-14
3	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	AKT1(4), AKT2(6), AKT3(11), BPNT1(3), GRB2(3), ILK(5), MAPK1(2), MAPK3(3), PDK1(2), PIK3CA(172), PIK3CD(12), PTEN(227), PTK2B(15), RBL2(19), SHC1(6), SOS1(13)	7243620	503	208	305	39	89	116	107	36	127	28	<1.00e-15	<1.00e-15	<3.87e-14
4	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	51	ACTA1(5), AGT(8), AKT1(4), CALM1(2), CALM2(3), CALR(3), CAMK1(3), CAMK1G(5), CAMK4(5), CREBBP(32), CSNK1A1(3), EDN1(4), ELSPBP1(5), F2(8), FKBP1A(1), GATA4(3), GSK3B(13), HAND1(6), HRAS(1), IGF1(5), LIF(3), MAP2K1(2), MAPK1(2), MAPK14(4), MAPK3(3), MAPK8(11), MEF2C(10), MYH2(41), NFATC1(10), NFATC2(13), NFATC3(11), NFATC4(5), NKX2-5(2), NPPA(2), PIK3CA(172), PIK3R1(99), PPP3CA(4), PPP3CB(6), PPP3CC(6), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), RAF1(9), RPS6KB1(3), SYT1(4)	18041266	568	206	439	96	127	166	134	5	116	20	3.96e-08	<1.00e-15	<3.87e-14
5	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	33	AKT1(4), BAD(1), BCL2L1(4), CBL(12), CFLAR(2), CRKL(6), E2F1(9), FOS(3), GRB2(3), HRAS(1), IL2RA(4), IL2RB(3), IL2RG(11), IRS1(13), JAK1(20), JAK3(10), MAPK1(2), MAPK3(3), MYC(8), NMI(3), PIK3CA(172), PIK3R1(99), PPIA(1), PTPN6(5), RAF1(9), RPS6KB1(3), SHC1(6), SOS1(13), STAT5A(5), STAT5B(7), SYK(4)	12777577	446	203	323	55	81	126	119	5	100	15	8.83e-10	<1.00e-15	<3.87e-14
6	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	CSNK2A1(9), ELK1(3), FOS(3), GRB2(3), HRAS(1), INS(1), INSR(18), IRS1(13), JUN(1), MAP2K1(2), MAPK3(3), MAPK8(11), PIK3CA(172), PIK3R1(99), PTPN11(8), RAF1(9), RASA1(29), SHC1(6), SLC2A4(9), SOS1(13), SRF(3)	9128952	416	202	289	36	79	113	106	5	97	16	4.30e-14	<1.00e-15	<3.87e-14
7	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	ADCY1(21), AKT1(4), ASAH1(6), GNAI1(5), GNB1(2), GNGT1(1), ITGAV(10), ITGB3(11), MAPK1(2), MAPK3(3), PDGFA(3), PDGFRA(24), PIK3CA(172), PIK3R1(99), PLCB1(5), PRKCA(11), PTK2(12), RAC1(1), SMPD1(4), SMPD2(6), SPHK1(2), SRC(3)	9845923	407	201	287	58	68	105	113	6	98	17	1.81e-06	<1.00e-15	<3.87e-14
8	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	ADCY1(21), AKT1(4), CAMK2A(9), CAMK2B(4), CAMK2D(5), CAMK2G(5), CREB1(5), GNAS(24), GRB2(3), HRAS(1), MAPK1(2), MAPK14(4), MAPK3(3), PIK3CA(172), PIK3R1(99), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PRKCA(11), RAC1(1), RPS6KA1(1), RPS6KA5(11), SOS1(13)	10330216	425	200	300	50	88	106	110	5	100	16	3.43e-09	<1.00e-15	<3.87e-14
9	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	CREBBP(32), EP300(32), FYN(5), IL2RG(11), IL7(1), IL7R(12), JAK1(20), JAK3(10), LCK(4), NMI(3), PIK3CA(172), PIK3R1(99), PTK2B(15), STAT5A(5), STAT5B(7)	10213532	428	200	305	53	74	113	113	6	106	16	1.41e-08	<1.00e-15	<3.87e-14
10	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	AKT1(4), BAD(1), CASP9(3), CHUK(8), GH1(2), GHR(8), NFKB1(10), NFKBIA(3), PDPK1(3), PIK3CA(172), PIK3R1(99), PPP2CA(6), RELA(6), YWHAH(3)	5135005	328	199	209	21	48	86	91	4	84	15	7.89e-12	<1.00e-15	<3.87e-14
11	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	AKT1(4), BCR(6), CRKL(6), FOS(3), GRB2(3), HRAS(1), JAK2(17), JUN(1), MAP2K1(2), MAP2K4(9), MAP3K1(30), MAPK3(3), MAPK8(11), MYC(8), PIK3CA(172), PIK3R1(99), RAF1(9), SOS1(13), STAT1(15), STAT5A(5), STAT5B(7)	9960926	424	199	299	36	75	115	112	4	99	19	5.77e-14	<1.00e-15	<3.87e-14
12	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	BTK(12), CALM1(2), CALM2(3), ELK1(3), FCER1A(9), FCER1G(2), FOS(3), GRB2(3), HRAS(1), JUN(1), LYN(9), MAP2K1(2), MAP2K4(9), MAP2K7(4), MAP3K1(30), MAPK1(2), MAPK3(3), MAPK8(11), NFATC1(10), NFATC2(13), NFATC3(11), NFATC4(5), PAK2(3), PIK3CA(172), PIK3R1(99), PLA2G4A(13), PLCG1(12), PPP3CA(4), PPP3CB(6), PPP3CC(6), RAF1(9), SHC1(6), SOS1(13), SYK(4), SYT1(4), VAV1(12)	15285000	511	198	384	74	100	150	122	6	117	16	3.34e-08	<1.00e-15	<3.87e-14
13	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	AKT1(4), DPM2(1), GRB2(3), HRAS(1), KLK2(2), NTRK1(13), PIK3CA(172), PIK3R1(99), PLCG1(12), PRKCA(11), SHC1(6), SOS1(13)	5625851	337	198	214	28	53	88	94	4	83	15	6.65e-10	<1.00e-15	<3.87e-14
14	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	AKT1(4), BAD(1), BCL2L1(4), CASP9(3), CDC42(3), CHUK(8), ELK1(3), H2AFX(1), HRAS(1), MAP2K1(2), MAPK3(3), NFKB1(10), PIK3CA(172), PIK3R1(99), RAC1(1), RAF1(9), RALA(6), RALBP1(6), RALGDS(9), RELA(6), RHOA(3)	6942603	354	197	233	27	56	99	94	4	84	17	2.14e-12	<1.00e-15	<3.87e-14
15	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	B2M(3), HLA-A(1), IL18(2), ITGB1(8), KLRC1(7), KLRC2(1), KLRC3(2), KLRC4(5), KLRD1(3), MAP2K1(2), MAPK3(3), PAK1(3), PIK3CA(172), PIK3R1(99), PTK2B(15), PTPN6(5), RAC1(1), SYK(4), VAV1(12)	6852023	348	196	228	33	57	91	91	5	89	15	2.21e-09	<1.00e-15	<3.87e-14
16	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	25	AKT1(4), AKT2(6), AKT3(11), BAD(1), GRB2(3), GSK3A(10), GSK3B(13), IL4R(6), IRS1(13), JAK1(20), JAK3(10), MAP4K1(12), MAPK1(2), MAPK3(3), PDK1(2), PIK3CA(172), PIK3CD(12), PIK3R1(99), PPP1R13B(9), RAF1(9), SHC1(6), SOS1(13), SOS2(17), STAT6(10)	12574116	463	202	336	53	103	116	118	5	105	16	2.71e-11	1.22e-15	3.87e-14
17	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	33	DUSP1(2), GORASP1(9), IKBKG(3), MAP2K4(9), MAP2K7(4), MAPK1(2), MAPK10(10), MAPK11(3), MAPK12(2), MAPK13(4), MAPK14(4), MAPK3(3), MAPK8(11), MAPK8IP1(4), MAPK8IP2(1), MAPK8IP3(9), MAPK9(4), MAPKAPK5(5), NFKB1(10), NFKB2(9), NFKBIA(3), NFKBIB(1), NFKBIE(6), NFKBIL1(1), PIK3CA(172), PIK3CD(12), PIK3R1(99), SYT1(4), TRAF2(3), TRAF3(5), TRAF5(7), TRAF6(7)	11364262	428	197	308	59	89	111	101	4	108	15	2.66e-08	1.22e-15	3.87e-14
18	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	CSNK2A1(9), DPM2(1), ELK1(3), FOS(3), GRB2(3), HRAS(1), JUN(1), KLK2(2), MAP2K1(2), MAPK3(3), MAPK8(11), NGFR(3), PIK3CA(172), PIK3R1(99), PLCG1(12), RAF1(9), SHC1(6), SOS1(13)	6810755	353	194	227	21	57	92	100	4	85	15	1.34e-14	1.22e-15	3.87e-14
19	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	22	ADCY1(21), AKT1(4), BAD(1), BAX(2), BCL2L1(4), CSF2RB(14), IGF1(5), IGF1R(13), IL3(2), IL3RA(9), KIT(23), KITLG(3), PIK3CA(172), PIK3R1(99), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), YWHAH(3)	7856210	402	200	282	53	73	110	106	6	91	16	9.92e-09	1.33e-15	3.87e-14
20	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	AKT1(4), EIF2B5(5), EIF2S1(2), EIF2S2(9), EIF2S3(6), EIF4E(1), GSK3B(13), IGF1(5), IGF1R(13), INPPL1(18), PDK2(4), PDPK1(3), PIK3CA(172), PIK3R1(99), PPP2CA(6), PTEN(227), RPS6(7), RPS6KB1(3)	7138255	597	217	382	44	78	118	113	40	206	42	<1.00e-15	1.44e-15	3.87e-14
21	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	28	AKT1(4), CABIN1(19), CALM1(2), CALM2(3), CAMK1(3), CAMK1G(5), HDAC5(12), IGF1(5), IGF1R(13), INS(1), INSR(18), MAP2K6(10), MAPK14(4), MAPK7(14), MEF2A(3), MEF2B(1), MEF2C(10), MEF2D(7), NFATC1(10), NFATC2(13), PIK3CA(172), PIK3R1(99), PPP3CA(4), PPP3CB(6), PPP3CC(6), SYT1(4), YWHAH(3)	12178275	451	201	328	71	105	112	113	8	98	15	2.05e-07	1.44e-15	3.87e-14
22	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	AKT1(4), CREB1(5), MAP2K1(2), MAP2K2(5), MAP2K3(7), MAP2K6(10), MAP3K1(30), MAPK1(2), MAPK14(4), MAPK3(3), NFKB1(10), PIK3CA(172), PIK3R1(99), RB1(26), RELA(6), SP1(7)	7166136	392	200	270	30	61	104	106	4	98	19	1.13e-12	1.44e-15	3.87e-14
23	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	7	HDAC1(5), MAX(9), MYC(8), SP1(7), SP3(10), TP53(74), WT1(3)	2507279	116	91	87	10	35	30	27	2	22	0	2.87e-06	1.44e-15	3.87e-14
24	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	CSNK2A1(9), FOS(3), GRB2(3), HRAS(1), JAK2(17), JUN(1), MAP2K1(2), MAPK3(3), MPL(7), PIK3CA(172), PIK3R1(99), PLCG1(12), PRKCA(11), RAF1(9), RASA1(29), SHC1(6), SOS1(13), STAT1(15), STAT3(11), STAT5A(5), STAT5B(7), THPO(5)	10932923	440	197	311	48	82	119	115	4	101	19	7.49e-10	1.67e-15	4.27e-14
25	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	24	GH1(2), GHR(8), GRB2(3), HRAS(1), INS(1), INSR(18), IRS1(13), JAK2(17), MAP2K1(2), MAPK1(2), MAPK3(3), PIK3CA(172), PIK3R1(99), PLCG1(12), PRKCA(11), PTPN6(5), RAF1(9), RPS6KA1(1), SHC1(6), SLC2A4(9), SOS1(13), SRF(3), STAT5A(5), STAT5B(7)	11855606	422	198	298	58	89	107	114	5	89	18	2.38e-07	1.89e-15	4.65e-14
26	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	ARNT(5), EIF1(1), EIF2B2(5), EIF2B3(7), EIF2B4(4), EIF2B5(5), EIF2S1(2), EIF2S2(9), EIF2S3(6), ELAVL1(8), FLT1(20), FLT4(8), HIF1A(16), HRAS(1), KDR(26), NOS3(11), PIK3CA(172), PIK3R1(99), PLCG1(12), PRKCA(11), PTK2(12), PXN(6), SHC1(6), VHL(3)	12174092	455	198	332	55	93	119	108	7	113	15	3.21e-10	2.00e-15	4.73e-14
27	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	16	ABL1(8), CDKN2A(1), E2F1(9), MDM2(5), MYC(8), PIK3CA(172), PIK3R1(99), POLR1A(15), POLR1B(16), POLR1C(2), POLR1D(3), RAC1(1), RB1(26), TBX2(2), TP53(74), TWIST1(1)	7080267	442	223	298	48	85	109	119	6	105	18	1.62e-10	2.44e-15	5.02e-14
28	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	48	AKT1(4), AKT2(6), AKT3(11), BRD4(10), CAP1(4), CBL(12), CDC42(3), CDKN2A(1), F2RL2(2), FLOT1(1), FLOT2(2), GRB2(3), GSK3A(10), GSK3B(13), IGFBP1(4), INPPL1(18), IRS1(13), IRS4(20), LNPEP(10), MAPK1(2), MAPK3(3), PARD3(19), PDK1(2), PIK3CA(172), PIK3CD(12), PIK3R1(99), PTEN(227), PTPN1(5), RAF1(9), RPS6KA1(1), RPS6KA2(13), RPS6KA3(19), RPS6KB1(3), SERPINB6(3), SHC1(6), SLC2A4(9), SORBS1(18), SOS1(13), SOS2(17), YWHAE(5), YWHAG(3), YWHAH(3), YWHAQ(1), YWHAZ(1)	20615343	812	217	588	114	152	178	168	40	229	45	2.07e-12	2.44e-15	5.02e-14
29	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	ARFIP2(1), CDK5(2), CDK5R1(3), CFL1(1), CHN1(2), LIMK1(8), MAP3K1(30), MYL2(2), MYLK(14), NCF2(8), PAK1(3), PDGFRA(24), PIK3CA(172), PIK3R1(99), PLD1(13), PPP1R12B(19), RAC1(1), RALBP1(6), RPS6KB1(3), TRIO(34), VAV1(12), WASF1(3)	12890193	460	200	335	67	88	126	113	6	108	19	4.41e-07	2.44e-15	5.02e-14
30	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	AKT1(4), BAD(1), GRB2(3), HRAS(1), IGF1R(13), IRS1(13), MAP2K1(2), MAPK1(2), MAPK3(3), PIK3CA(172), PIK3R1(99), RAF1(9), SHC1(6), SOS1(13), YWHAH(3)	6731221	344	196	221	33	61	84	96	5	83	15	2.35e-09	2.44e-15	5.02e-14
31	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	AKT1(4), AKT2(6), AKT3(11), CDKN1A(1), ELK1(3), GRB2(3), HRAS(1), MAP2K1(2), MAP2K2(5), NGFR(3), NTRK1(13), PIK3CA(172), PIK3CD(12), SHC1(6), SOS1(13)	5624797	255	151	154	31	58	92	82	3	20	0	2.26e-08	2.55e-15	5.04e-14
32	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	ADRB2(7), AKT1(4), ANXA1(4), CALM1(2), CALM2(3), GNAS(24), GNB1(2), GNGT1(1), NFKB1(10), NOS3(11), NPPA(2), NR3C1(17), PIK3CA(172), PIK3R1(99), RELA(6), SYT1(4)	6288912	368	197	245	25	79	91	90	4	89	15	6.48e-14	2.78e-15	5.04e-14
33	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	35	ACTA1(5), CRK(2), CRKL(6), DOCK1(21), ELK1(3), FOS(3), GAB1(7), GRB2(3), HGF(14), HRAS(1), ITGA1(17), ITGB1(8), JUN(1), MAP2K1(2), MAP2K2(5), MAP4K1(12), MAPK1(2), MAPK3(3), MAPK8(11), MET(17), PAK1(3), PIK3CA(172), PIK3R1(99), PTEN(227), PTK2(12), PTK2B(15), PTPN11(8), PXN(6), RAF1(9), RAP1A(4), RAP1B(2), RASA1(29), SOS1(13), SRC(3), STAT3(11)	16563754	756	217	536	89	129	178	144	37	224	44	<1.00e-15	2.89e-15	5.04e-14
34	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	AKT1(4), CCND1(14), CCNE1(6), CDK2(2), CDK4(2), CDK6(3), CDKN1A(1), CDKN1B(7), E2F1(9), HRAS(1), MAPK1(2), MAPK3(3), NFKB1(10), NFKBIA(3), PAK1(3), PIK3CA(172), PIK3R1(99), RAC1(1), RAF1(9), RB1(26), RELA(6), TFDP1(13)	7293532	396	202	272	37	66	101	106	4	101	18	3.46e-11	2.89e-15	5.04e-14
35	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	12	AKT1(4), CAT(4), GH1(2), GHR(8), HRAS(1), IGF1(5), IGF1R(13), PIK3CA(172), PIK3R1(99), SHC1(6), SOD1(2), SOD2(3)	4715937	319	195	200	28	51	77	90	5	81	15	2.89e-09	2.89e-15	5.04e-14
36	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	CSNK2A1(9), ELK1(3), FOS(3), GRB2(3), HRAS(1), IGF1(5), IGF1R(13), IRS1(13), JUN(1), MAP2K1(2), MAPK3(3), MAPK8(11), PIK3CA(172), PIK3R1(99), PTPN11(8), RAF1(9), RASA1(29), SHC1(6), SOS1(13), SRF(3)	8874392	406	200	279	33	71	111	106	5	97	16	3.47e-14	3.00e-15	5.04e-14
37	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	AKT1(4), BCAR1(8), CDKN1B(7), GRB2(3), ILK(5), ITGB1(8), MAPK1(2), MAPK3(3), PDK2(4), PDPK1(3), PIK3CA(172), PIK3R1(99), PTEN(227), PTK2(12), SHC1(6), SOS1(13)	6867110	576	213	361	29	70	112	123	37	192	42	<1.00e-15	3.11e-15	5.04e-14
38	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	AKT1(4), PIK3CA(172), PIK3R1(99), PLCB1(5), PLCG1(12), PRKCA(11), VAV1(12)	4719996	315	195	195	36	51	68	90	7	84	15	1.53e-05	3.11e-15	5.04e-14
39	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	9	CHUK(8), DNAJC3(8), EIF2S1(2), EIF2S2(9), NFKB1(10), NFKBIA(3), RELA(6), TP53(74)	3670290	120	82	93	8	31	37	24	2	26	0	9.02e-07	3.22e-15	5.09e-14
40	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	BCAR1(8), CRK(2), CXCL12(3), CXCR4(1), GNAI1(5), GNAQ(3), GNB1(2), GNGT1(1), HRAS(1), MAP2K1(2), MAPK1(2), MAPK3(3), NFKB1(10), PIK3C2G(16), PIK3CA(172), PIK3R1(99), PLCG1(12), PRKCA(11), PTK2(12), PTK2B(15), PXN(6), RAF1(9), RELA(6)	10130836	401	197	280	55	79	101	107	4	95	15	7.00e-07	3.55e-15	5.47e-14
41	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	AKT1(4), BAD(1), CHRNB1(2), CHRNG(4), MUSK(14), PIK3CA(172), PIK3R1(99), PTK2(12), PTK2B(15), RAPSN(2), SRC(3), TERT(4), YWHAH(3)	5901003	335	196	216	43	56	85	93	4	82	15	4.08e-06	3.77e-15	5.67e-14
42	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD28(3), CD3D(6), CD3E(2), CD3G(3), CD80(5), CD86(5), CTLA4(2), GRB2(3), HLA-DRA(1), ICOS(3), IL2(2), ITK(7), LCK(4), PIK3CA(172), PIK3R1(99), PTPN11(8)	4602586	325	194	206	16	48	85	87	5	85	15	5.17e-14	4.11e-15	6.02e-14
43	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	A1BG(3), AKT1(4), AKT2(6), AKT3(11), BAD(1), BTK(12), CDKN2A(1), DAPP1(9), GRB2(3), GSK3A(10), GSK3B(13), IARS(8), IGFBP1(4), INPP5D(9), PDK1(2), PIK3CA(172), PPP1R13B(9), PTEN(227), RPS6KA1(1), RPS6KA2(13), RPS6KA3(19), RPS6KB1(3), SHC1(6), SOS1(13), SOS2(17), TEC(7), YWHAE(5), YWHAG(3), YWHAH(3), YWHAQ(1), YWHAZ(1)	13065934	596	211	398	67	107	149	129	37	144	30	1.98e-14	4.22e-15	6.04e-14
44	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	AKT1(4), EIF4A1(5), EIF4A2(8), EIF4E(1), EIF4G1(16), EIF4G2(7), EIF4G3(23), GHR(8), IRS1(13), MAPK1(2), MAPK14(4), MAPK3(3), MKNK1(3), PABPC1(10), PDK2(4), PDPK1(3), PIK3CA(172), PIK3R1(99), PRKCA(11), PTEN(227), RPS6KB1(3)	10144798	626	216	412	47	90	121	129	39	203	44	<1.00e-15	4.44e-15	6.22e-14
45	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	49	ACOX1(7), APOA1(3), APOA2(2), CD36(8), CPT1B(6), CREBBP(32), DUSP1(2), EHHADH(10), EP300(32), FABP1(4), HSD17B4(12), INS(1), JUN(1), LPL(16), MAPK1(2), MAPK3(3), ME1(12), MRPL11(1), MYC(8), NCOA1(19), NCOR1(22), NCOR2(24), NFKBIA(3), NR0B2(2), NR1H3(4), NR2F1(7), NRIP1(17), PDGFA(3), PIK3CA(172), PIK3R1(99), PPARA(2), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PRKCA(11), PTGS2(9), RB1(26), RELA(6), RXRA(3), SP1(7), STAT5A(5), STAT5B(7)	22410854	637	204	510	99	135	184	156	8	131	23	2.41e-10	4.55e-15	6.23e-14
46	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	42	AKT1(4), ASAH1(6), ATF1(6), BRAF(10), CAMP(1), CREB1(5), CREB5(5), CREBBP(32), CRKL(6), DAG1(6), EGR1(6), EGR2(6), EGR3(7), EGR4(5), ELK1(3), FRS2(5), GNAQ(3), JUN(1), MAP1B(35), MAP2K4(9), MAP2K7(4), MAPK1(2), MAPK10(10), MAPK3(3), MAPK8(11), MAPK8IP1(4), MAPK8IP2(1), MAPK8IP3(9), MAPK9(4), NTRK1(13), OPN1LW(7), PIK3C2G(16), PIK3CA(172), PIK3CD(12), PIK3R1(99), PTPN11(8), RPS6KA3(19), SHC1(6), SRC(3), TERF2IP(2), TH(3)	18159846	569	205	444	97	128	175	125	5	119	17	1.35e-08	5.11e-15	6.43e-14
47	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	AKT1(4), CREB1(5), GRB2(3), HRAS(1), MAPK1(2), MAPK3(3), MAPK7(14), MEF2A(3), MEF2B(1), MEF2C(10), MEF2D(7), NTRK1(13), PIK3CA(172), PIK3R1(99), PLCG1(12), RPS6KA1(1), SHC1(6)	7017966	356	198	236	34	64	91	94	6	86	15	3.62e-10	5.11e-15	6.43e-14
48	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ACTR2(6), ACTR3(1), ARPC1A(6), ARPC1B(5), ARPC2(1), ARPC3(1), ARPC4(1), CDC42(3), PAK1(3), PDGFRA(24), PIK3CA(172), PIK3R1(99), RAC1(1), WASL(8)	4979142	331	195	211	14	51	82	91	4	87	16	<1.00e-15	5.11e-15	6.43e-14
49	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(9), ELK1(3), FOS(3), GRB2(3), HRAS(1), JAK1(20), JUN(1), MAP2K1(2), MAP2K4(9), MAP3K1(30), MAPK3(3), MAPK8(11), PDGFA(3), PDGFRA(24), PIK3CA(172), PIK3R1(99), PLCG1(12), PRKCA(11), RAF1(9), RASA1(29), SHC1(6), SOS1(13), SRF(3), STAT1(15), STAT3(11), STAT5A(5)	12730148	507	202	376	51	93	135	132	4	125	18	1.04e-13	5.22e-15	6.43e-14
50	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(21), DIAPH1(12), FYN(5), GSN(4), HRAS(1), ITGA1(17), ITGB1(8), MAP2K1(2), MAPK1(2), MAPK3(3), MYL2(2), MYLK(14), PFN1(1), PIK3CA(172), PIK3R1(99), PTK2(12), PXN(6), RAF1(9), ROCK1(22), SHC1(6), SRC(3), TLN1(23)	13836087	444	199	324	50	90	122	113	4	97	18	1.68e-10	5.22e-15	6.43e-14
51	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	ADCY1(21), ARHGEF1(12), F2(8), F2R(6), GNA12(7), GNA13(7), GNAI1(5), GNAQ(3), GNB1(2), GNGT1(1), MAP3K7(9), PIK3CA(172), PIK3R1(99), PLCB1(5), PPP1R12B(19), PRKCA(11), PTK2B(15), ROCK1(22)	9289594	424	199	301	59	94	105	110	7	90	18	5.10e-07	5.66e-15	6.84e-14
52	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	15	ARF1(3), ARF3(4), CCND1(14), CDK2(2), CDK4(2), CDKN1A(1), CDKN1B(7), CDKN2A(1), CFL1(1), E2F1(9), E2F2(3), MDM2(5), PRB1(2), TP53(74)	2834146	128	98	102	21	33	37	31	1	26	0	0.00296	5.88e-15	6.97e-14
53	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(9), EGF(19), EGFR(12), ELK1(3), FOS(3), GRB2(3), HRAS(1), JAK1(20), JUN(1), MAP2K1(2), MAP2K4(9), MAP3K1(30), MAPK3(3), MAPK8(11), PIK3CA(172), PIK3R1(99), PLCG1(12), PRKCA(11), RAF1(9), RASA1(29), SHC1(6), SOS1(13), SRF(3), STAT1(15), STAT3(11), STAT5A(5)	13675029	511	200	380	56	97	136	129	4	128	17	2.51e-12	6.00e-15	6.97e-14
54	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	7	ATM(54), ATR(38), CDC25C(5), CHEK1(2), CHEK2(13), TP53(74), YWHAH(3)	5921097	189	102	161	19	41	58	40	1	45	4	8.53e-05	6.88e-15	7.83e-14
55	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	CALM1(2), CALM2(3), CD3D(6), CD3E(2), CD3G(3), ELK1(3), FOS(3), FYN(5), GRB2(3), HRAS(1), JUN(1), LCK(4), MAP2K1(2), MAP2K4(9), MAP3K1(30), MAPK3(3), MAPK8(11), NFATC1(10), NFATC2(13), NFATC3(11), NFATC4(5), NFKB1(10), NFKBIA(3), PIK3CA(172), PIK3R1(99), PLCG1(12), PPP3CA(4), PPP3CB(6), PPP3CC(6), PRKCA(11), PTPN7(6), RAC1(1), RAF1(9), RASA1(29), RELA(6), SHC1(6), SOS1(13), SYT1(4), VAV1(12), ZAP70(8)	17112318	547	201	418	76	115	154	126	5	130	17	4.55e-10	6.99e-15	7.83e-14
56	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	33	AKT1(4), AKT2(6), AKT3(11), BCR(6), BTK(12), CD19(4), CDKN2A(1), DAPP1(9), FLOT1(1), FLOT2(2), GAB1(7), ITPR1(34), ITPR2(35), ITPR3(22), LYN(9), NR0B2(2), PDK1(2), PHF11(5), PIK3CA(172), PITX2(8), PLCG2(27), PPP1R13B(9), PREX1(25), PTEN(227), PTPRC(17), RPS6KA1(1), RPS6KA2(13), RPS6KA3(19), RPS6KB1(3), SAG(6), SYK(4), TEC(7), VAV1(12)	20146159	722	212	526	128	140	212	138	38	163	31	5.16e-09	6.43e-14	7.07e-13
57	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	12	ATM(54), CDC25A(8), CDC25B(3), CDC25C(5), CDK2(2), CDK4(2), CHEK1(2), MYT1(18), RB1(26), TP53(74), WEE1(2), YWHAH(3)	6552026	199	105	169	25	52	58	39	1	43	6	6.55e-05	1.46e-11	1.58e-10
58	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	44	AKT1(4), AKT2(6), AKT3(11), BRAF(10), CAB39(6), DDIT4(2), EIF4B(7), FIGF(5), HIF1A(16), IGF1(5), INS(1), MAPK1(2), MAPK3(3), PDPK1(3), PGF(3), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(99), PIK3R2(7), PIK3R3(9), PIK3R5(10), PRKAA1(8), PRKAA2(11), RHEB(3), RICTOR(21), RPS6(7), RPS6KA1(1), RPS6KA2(13), RPS6KA3(19), RPS6KA6(19), RPS6KB1(3), RPS6KB2(4), STK11(2), TSC1(12), TSC2(14), ULK1(5), ULK2(11), ULK3(5), VEGFA(2), VEGFB(3), VEGFC(6)	18585019	602	207	472	95	135	170	147	5	128	17	3.10e-08	4.45e-11	4.73e-10
59	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	64	APAF1(17), ATM(54), ATR(38), BAI1(10), BAX(2), BID(2), CASP3(4), CASP8(21), CASP9(3), CCNB1(8), CCNB2(5), CCNB3(33), CCND1(14), CCND2(9), CCND3(4), CCNE1(6), CCNE2(8), CCNG1(9), CCNG2(2), CD82(5), CDK2(2), CDK4(2), CDK6(3), CDKN1A(1), CDKN2A(1), CHEK1(2), CHEK2(13), CYCS(2), DDB2(6), EI24(3), FAS(8), GADD45G(1), GTSE1(2), IGF1(5), IGFBP3(4), MDM2(5), MDM4(4), PERP(4), PPM1D(13), PTEN(227), RCHY1(5), RFWD2(4), RRM2(6), RRM2B(5), SERPINB5(1), SERPINE1(5), SESN1(5), SESN2(3), SESN3(15), SIAH1(6), STEAP3(9), THBS1(10), TNFRSF10B(5), TP53(74), TP53I3(2), TP73(5), TSC2(14), ZMAT3(11)	23077507	747	225	616	132	129	216	126	34	208	34	2.59e-07	3.06e-08	3.20e-07
60	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	ACTR2(6), ACTR3(1), AKT1(4), AKT2(6), AKT3(11), ANGPTL2(6), ARHGAP1(2), ARHGAP4(10), ARHGEF11(20), BTK(12), CDC42(3), CFL1(1), CFL2(8), GDI1(4), GDI2(1), INPPL1(18), ITPR1(34), ITPR2(35), ITPR3(22), LIMK1(8), MYLK(14), MYLK2(8), PAK1(3), PAK2(3), PAK3(16), PAK6(4), PAK7(9), PDK1(2), PIK3CA(172), PIK3CD(12), PIK3CG(23), PIK3R1(99), PITX2(8), PPP1R13B(9), PTEN(227), RACGAP1(9), RHO(4), ROCK1(22), ROCK2(17), RPS4X(1), SAG(6), WASF1(3), WASL(8)	25475732	891	219	670	155	164	251	158	38	235	45	4.19e-09	6.55e-08	6.72e-07
61	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(56), AXIN1(9), BTRC(14), CCND1(14), CREBBP(32), CSNK1A1(3), CSNK1D(3), CSNK2A1(9), CTBP1(1), CTNNB1(80), DVL1(3), FZD1(3), GSK3B(13), HDAC1(5), MAP3K7(9), MYC(8), NLK(5), PPARD(3), PPP2CA(6), TLE1(13), WIF1(5), WNT1(1)	10502166	295	132	228	48	65	138	47	2	39	4	4.11e-06	7.25e-08	7.32e-07
62	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	13	CREBBP(32), DAXX(9), HRAS(1), PAX3(5), PML(6), RARA(2), RB1(26), SIRT1(6), SP100(20), TNFRSF1A(4), TNFRSF1B(2), TP53(74)	6641355	187	97	159	30	59	53	33	1	36	5	7.03e-05	1.47e-06	1.46e-05
63	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	62	AKT1(4), AKT2(6), AKT3(11), BAD(1), BCL2L1(4), CDC42(3), CDK2(2), CDKN1B(7), CDKN2A(1), CREB1(5), CREB5(5), EBP(2), ERBB4(27), F2RL2(2), GAB1(7), GRB2(3), GSK3A(10), GSK3B(13), IGF1(5), IGFBP1(4), INPPL1(18), IRS1(13), IRS4(20), MET(17), MYC(8), NOLC1(14), PAK1(3), PAK2(3), PAK3(16), PAK6(4), PAK7(9), PARD3(19), PDK1(2), PIK3CA(172), PIK3CD(12), PPP1R13B(9), PREX1(25), PTEN(227), PTK2(12), PTPN1(5), RPS6KA1(1), RPS6KA2(13), RPS6KA3(19), RPS6KB1(3), SHC1(6), SLC2A4(9), SOS1(13), SOS2(17), TSC1(12), TSC2(14), YWHAE(5), YWHAG(3), YWHAH(3), YWHAQ(1), YWHAZ(1)	26909150	850	216	647	148	180	235	181	41	182	31	5.29e-11	2.60e-06	2.54e-05
64	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CCNE1(6), CDK2(2), CUL1(13), E2F1(9), FBXW7(44), RB1(26), TFDP1(13)	3092136	113	60	95	17	42	31	17	1	18	4	0.000350	4.14e-05	0.000398
65	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	16	APAF1(17), ATM(54), BAX(2), CCND1(14), CCNE1(6), CDK2(2), CDK4(2), CDKN1A(1), E2F1(9), MDM2(5), PCNA(3), RB1(26), TIMP3(7), TP53(74)	6638149	222	116	192	34	45	69	52	1	49	6	0.000464	4.47e-05	0.000424
66	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	21	ATM(54), ATR(38), BRCA1(17), BRCA2(52), CHEK1(2), CHEK2(13), FANCA(15), FANCC(9), FANCD2(11), FANCE(10), FANCF(1), FANCG(10), HUS1(3), MRE11A(10), RAD1(6), RAD17(13), RAD50(18), RAD51(2), RAD9A(2), TP53(74)	16271430	360	118	328	44	74	142	72	1	65	6	1.44e-07	0.000152	0.00142
67	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	ACTR2(6), ACTR3(1), AKT1(4), ANGPTL2(6), DAG1(6), DGKA(9), ETFA(5), GCA(3), ITGA9(16), ITPKA(1), ITPKB(11), ITPR1(34), ITPR2(35), ITPR3(22), MAP2K1(2), MAPK1(2), MAPK3(3), NR1I3(4), PAK1(3), PDE3A(19), PDE3B(15), PI3(2), PIK3C2G(16), PIK3CA(172), PIK3CD(12), PIK3R1(99), PSME1(1), RIPK3(5), RPS4X(1), SGCB(4), VASP(3)	17891218	522	204	400	100	111	155	116	6	117	17	4.23e-05	0.000258	0.00237
68	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	34	AKT1(4), APC(56), AR(12), ASAH1(6), BRAF(10), CAMP(1), CCL13(2), CCL15(1), CCL16(1), DAG1(6), EGFR(12), GNA11(2), GNA15(1), GNAI1(5), GNAQ(3), ITPKA(1), ITPKB(11), ITPR1(34), ITPR2(35), ITPR3(22), KCNJ3(9), KCNJ5(7), KCNJ9(4), MAPK1(2), MAPK10(10), MAPK14(4), PHKA2(21), PIK3CA(172), PIK3CD(12), PIK3R1(99), PITX2(8), PTX3(2), RAF1(9), SRC(3)	19350915	587	210	461	118	120	188	126	7	126	20	3.01e-05	0.00249	0.0225
69	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	AKT1(4), AKT2(6), AKT3(11), BAD(1), BCR(6), BLNK(4), BTK(12), CD19(4), CSK(1), DAG1(6), EPHB2(11), GRB2(3), ITPKA(1), ITPKB(11), LYN(9), MAP2K1(2), MAP2K2(5), MAPK1(2), NFAT5(16), NFKB1(10), NFKB2(9), NFKBIA(3), NFKBIB(1), NFKBIE(6), NFKBIL1(1), PI3(2), PIK3CA(172), PIK3CD(12), PIK3R1(99), PLCG2(27), PPP1R13B(9), RAF1(9), SERPINA4(4), SHC1(6), SOS1(13), SOS2(17), SYK(4), VAV1(12)	18448082	531	202	405	110	114	162	126	6	107	16	0.000513	0.0102	0.0911
70	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	47	FN3K(5), IMPA1(3), IMPA2(6), INPP1(3), INPP4A(19), INPP4B(16), INPP5A(4), INPP5B(5), INPP5E(1), INPPL1(18), IPMK(4), ISYNA1(2), ITPK1(4), ITPKA(1), ITPKB(11), MINPP1(3), MIOX(5), OCRL(19), PI4KA(17), PI4KB(9), PIK3C3(14), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIP4K2A(5), PIP4K2B(7), PIP4K2C(3), PIP5K1A(8), PIP5K1B(5), PIP5K1C(6), PLCB1(5), PLCB2(8), PLCB3(11), PLCB4(19), PLCD1(4), PLCD3(3), PLCD4(10), PLCE1(39), PLCG1(12), PLCG2(27), PLCZ1(13), PTEN(227), PTPMT1(2), SYNJ1(29), SYNJ2(11)	26523385	847	212	647	164	200	221	175	40	183	28	1.82e-08	0.0108	0.0950
71	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT1(4), AKT2(6), AKT3(11), CISH(2), GRB2(3), IARS(8), IL13RA1(11), IL2RG(11), IL4(1), IL4R(6), INPP5D(9), JAK1(20), JAK2(17), JAK3(10), NR0B2(2), PI3(2), PIK3CA(172), PPP1R13B(9), RPS6KB1(3), SERPINA4(4), SHC1(6), SOS1(13), SOS2(17), SRC(3), STAT6(10), TYK2(10)	13260226	370	155	269	72	74	134	109	6	43	4	0.000163	0.0120	0.104
72	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	81	AIFM1(12), AKT1(4), AKT2(6), AKT3(11), APAF1(17), ATM(54), BAD(1), BAX(2), BCL2L1(4), BID(2), BIRC2(10), BIRC3(5), CAPN1(5), CAPN2(11), CASP10(8), CASP3(4), CASP6(7), CASP7(1), CASP8(21), CASP9(3), CFLAR(2), CHUK(8), CSF2RB(14), CYCS(2), DFFB(4), ENDOG(1), FADD(1), FAS(8), FASLG(7), IKBKB(13), IKBKG(3), IL1B(2), IL1R1(5), IL1RAP(8), IL3(2), IL3RA(9), IRAK1(4), IRAK2(9), IRAK3(10), IRAK4(7), MYD88(2), NFKB1(10), NFKB2(9), NFKBIA(3), NTRK1(13), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(99), PIK3R2(7), PIK3R3(9), PIK3R5(10), PPP3CA(4), PPP3CB(6), PPP3CC(6), PPP3R1(1), PRKACA(6), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), RELA(6), RIPK1(8), TNFRSF10A(2), TNFRSF10B(5), TNFRSF10C(4), TNFRSF10D(6), TNFRSF1A(4), TNFSF10(1), TP53(74), TRAF2(3)	30167075	856	231	696	153	182	273	181	6	195	19	3.25e-09	0.0496	0.424
73	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1	CMBL(3)	187727	3	3	3	1	0	1	0	1	1	0	0.806	0.198	1.000
74	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	74	AKT1(4), AKT2(6), AKT3(11), BTK(12), CSF2(1), FCER1A(9), FCER1G(2), FYN(5), GAB2(10), GRB2(3), HRAS(1), IL3(2), IL4(1), IL5(2), INPP5D(9), KRAS(52), LCP2(5), LYN(9), MAP2K1(2), MAP2K2(5), MAP2K3(7), MAP2K4(9), MAP2K6(10), MAP2K7(4), MAPK1(2), MAPK10(10), MAPK11(3), MAPK12(2), MAPK13(4), MAPK14(4), MAPK3(3), MAPK8(11), MAPK9(4), MS4A2(3), NRAS(9), PDK1(2), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(99), PIK3R2(7), PIK3R3(9), PIK3R5(10), PLA2G12A(1), PLA2G12B(4), PLA2G2D(2), PLA2G2E(5), PLA2G2F(3), PLA2G3(7), PLA2G4A(13), PLA2G5(1), PLA2G6(9), PLCG1(12), PLCG2(27), PRKCA(11), PRKCD(5), PRKCE(10), RAC1(1), RAC2(2), RAF1(9), SOS1(13), SOS2(17), SYK(4), VAV1(12), VAV2(7), VAV3(13)	25702425	775	211	597	150	179	259	169	9	143	16	1.99e-07	0.201	1.000
75	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	69	AKT1(4), AKT2(6), AKT3(11), BAD(1), CASP9(3), CDC42(3), HRAS(1), KDR(26), KRAS(52), MAP2K1(2), MAP2K2(5), MAPK1(2), MAPK11(3), MAPK12(2), MAPK13(4), MAPK14(4), MAPK3(3), MAPKAPK2(5), MAPKAPK3(5), NFAT5(16), NFATC1(10), NFATC2(13), NFATC3(11), NFATC4(5), NOS3(11), NRAS(9), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(99), PIK3R2(7), PIK3R3(9), PIK3R5(10), PLA2G12A(1), PLA2G12B(4), PLA2G2D(2), PLA2G2E(5), PLA2G2F(3), PLA2G3(7), PLA2G4A(13), PLA2G5(1), PLA2G6(9), PLCG1(12), PLCG2(27), PPP3CA(4), PPP3CB(6), PPP3CC(6), PPP3R1(1), PRKCA(11), PRKCG(8), PTGS2(9), PTK2(12), PXN(6), RAC1(1), RAC2(2), RAF1(9), SH2D2A(2), SHC2(5), SPHK1(2), SPHK2(2), SRC(3), VEGFA(2)	25185120	741	210	567	148	188	240	161	8	129	15	2.51e-07	0.235	1.000
76	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(6), CSF1(6), IL6(5), LDLR(7), LPL(16)	1914084	40	24	40	6	10	15	9	0	6	0	0.0247	0.246	1.000
77	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CCR5(6), CD28(3), CD3D(6), CD3E(2), CD3G(3), CD4(6)	1210424	26	16	26	5	2	17	0	0	7	0	0.164	0.265	1.000
78	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	63	AKT1(4), AKT2(6), AKT3(11), BCL10(3), BLNK(4), BTK(12), CARD11(22), CD19(4), CD22(14), CD72(1), CD79A(1), CD79B(2), CHUK(8), CR2(22), FCGR2B(3), FOS(3), GSK3B(13), HRAS(1), IKBKB(13), IKBKG(3), INPP5D(9), JUN(1), KRAS(52), LILRB3(4), LYN(9), MALT1(4), NFAT5(16), NFATC1(10), NFATC2(13), NFATC3(11), NFATC4(5), NFKB1(10), NFKB2(9), NFKBIA(3), NFKBIB(1), NFKBIE(6), NRAS(9), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(99), PIK3R2(7), PIK3R3(9), PIK3R5(10), PLCG2(27), PPP3CA(4), PPP3CB(6), PPP3CC(6), PPP3R1(1), PTPN6(5), RAC1(1), RAC2(2), RASGRP3(11), SYK(4), VAV1(12), VAV2(7), VAV3(13)	26552098	770	208	600	155	176	269	165	7	138	15	3.84e-07	0.299	1.000
79	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	19	ABL1(8), ATM(54), BRCA1(17), CDKN1A(1), CHEK1(2), CHEK2(13), JUN(1), MAPK8(11), MDM2(5), MRE11A(10), NFKB1(10), NFKBIA(3), RAD50(18), RAD51(2), RBBP8(11), RELA(6), TP53(74), TP73(5)	10702357	251	112	223	46	54	82	55	1	56	3	0.00723	0.310	1.000
80	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(8)	264662	8	6	8	1	2	4	2	0	0	0	0.297	0.310	1.000
81	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3D(6), CD3E(2), CD3G(3)	433293	11	7	11	1	1	7	0	0	3	0	0.181	0.401	1.000
82	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	20	AKT1(4), APAF1(17), ATM(54), BAD(1), BAX(2), BCL2L1(4), BID(2), CASP3(4), CASP6(7), CASP7(1), CASP9(3), CYCS(2), EIF2S1(2), PRKCA(11), PTK2(12), PXN(6), STAT1(15), TLN1(23), TP53(74)	10101713	244	115	215	47	64	73	53	1	50	3	0.00255	0.419	1.000
83	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	17	ABCB1(32), AKT1(4), ATM(54), BAX(2), CDKN1A(1), CPB2(7), CSNK1A1(3), CSNK1D(3), FHL2(2), HIF1A(16), IGFBP3(4), MAPK8(11), MDM2(5), NFKBIB(1), NQO1(3), TP53(74)	7267170	222	112	192	44	54	66	49	2	46	5	0.0203	0.429	1.000
84	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(6), CDK2(2), CDKN1B(7), CKS1B(1), CUL1(13), E2F1(9), RB1(26), RBX1(1), SKP2(6), TFDP1(13)	3169643	84	38	82	17	26	25	17	0	13	3	0.0292	0.432	1.000
85	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(6), GSTZ1(5), HGD(4)	822142	15	12	15	2	5	4	4	0	2	0	0.107	0.458	1.000
86	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	ADAM17(11), APC(56), AXIN1(9), BTRC(14), CTNNB1(80), DLL1(6), DVL1(3), FZD1(3), GSK3B(13), NOTCH1(10), PSEN1(5), WNT1(1)	6996633	211	110	152	51	38	111	31	2	25	4	0.0289	0.477	1.000
87	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(5), SLPI(2)	572860	7	7	6	0	1	4	2	0	0	0	0.148	0.525	1.000
88	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(6), TPI1(2)	582980	8	7	8	1	0	3	1	0	4	0	0.273	0.535	1.000
89	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	AKT1(4), AKT2(6), AKT3(11), BAD(1), BCR(6), BLNK(4), BTK(12), CD19(4), CD22(14), CR2(22), CSK(1), DAG1(6), FLOT1(1), FLOT2(2), GRB2(3), GSK3A(10), GSK3B(13), INPP5D(9), ITPR1(34), ITPR2(35), ITPR3(22), LYN(9), MAP4K1(12), MAPK1(2), MAPK3(3), NFATC1(10), NFATC2(13), NR0B2(2), PDK1(2), PIK3CA(172), PIK3CD(12), PIK3R1(99), PLCG2(27), PPP1R13B(9), PPP3CA(4), PPP3CB(6), PPP3CC(6), PTPRC(17), RAF1(9), SHC1(6), SOS1(13), SOS2(17), SYK(4), VAV1(12)	26363173	686	203	557	147	161	219	152	8	129	17	2.79e-05	0.538	1.000
90	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(9), GOT2(3), TAT(7)	959929	19	13	19	2	6	6	5	1	1	0	0.0879	0.563	1.000
91	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(4), CD34(1), CD3D(6), CD3E(2), CD3G(3), CD4(6), CD58(2), CD8A(2), CSF3(1), IL3(2), IL6(5), KITLG(3)	2309359	37	26	37	9	4	19	4	0	10	0	0.256	0.611	1.000
92	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	25	ABL1(8), ATM(54), ATR(38), CCNA1(5), CCND1(14), CCNE1(6), CDC25A(8), CDK2(2), CDK4(2), CDK6(3), CDKN1A(1), CDKN1B(7), CDKN2A(1), DHFR(4), E2F1(9), GSK3B(13), HDAC1(5), RB1(26), SKP2(6), TFDP1(13), TGFB1(1), TGFB2(5), TGFB3(9), TP53(74)	10840158	314	131	282	66	80	97	58	1	71	7	0.00755	0.613	1.000
93	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(6), ACAT2(4), HMGCL(2), OXCT1(10)	1250166	22	15	21	3	8	7	3	0	4	0	0.118	0.615	1.000
94	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(6), LPL(16), NR3C1(17), PPARG(6), RETN(1), RXRA(3)	1931315	49	24	48	9	12	19	7	1	10	0	0.0334	0.644	1.000
95	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(5), CCNA2(7), CCND1(14), CCNE1(6), CCNE2(8), CDK2(2), CDK4(2), CDKN1B(7), CDKN2A(1), E2F1(9), E2F2(3), E2F4(3), PRB1(2)	3060313	69	43	67	16	9	26	21	0	13	0	0.199	0.684	1.000
96	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	12	CREB1(5), FOS(3), JUN(1), KEAP1(8), MAFK(1), MAPK1(2), MAPK14(4), MAPK8(11), NFE2L2(14), PRKCA(11)	3125025	60	39	57	11	16	15	16	3	10	0	0.0291	0.690	1.000
97	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(8), GOT1(9), GOT2(3), TAT(7), TYR(12)	1718364	39	20	39	5	10	13	12	1	3	0	0.0300	0.706	1.000
98	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	99	AKT1(4), AKT2(6), AKT3(11), CASP8(21), CCL4(5), CCL5(2), CD14(2), CD40(1), CD80(5), CD86(5), CHUK(8), CXCL10(2), CXCL9(2), FADD(1), FOS(3), IFNA1(2), IFNA10(3), IFNA13(3), IFNA14(4), IFNA16(3), IFNA17(3), IFNA2(2), IFNA21(1), IFNA4(3), IFNA5(5), IFNA6(2), IFNA7(1), IFNA8(3), IFNAR1(7), IFNAR2(8), IFNB1(3), IKBKB(13), IKBKE(4), IKBKG(3), IL12A(5), IL12B(2), IL1B(2), IL6(5), IRAK1(4), IRAK4(7), IRF3(2), IRF5(6), IRF7(1), JUN(1), LBP(3), LY96(4), MAP2K1(2), MAP2K2(5), MAP2K3(7), MAP2K4(9), MAP2K6(10), MAP2K7(4), MAP3K7(9), MAP3K8(10), MAPK1(2), MAPK10(10), MAPK11(3), MAPK12(2), MAPK13(4), MAPK14(4), MAPK3(3), MAPK8(11), MAPK9(4), MYD88(2), NFKB1(10), NFKB2(9), NFKBIA(3), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(99), PIK3R2(7), PIK3R3(9), PIK3R5(10), RAC1(1), RELA(6), RIPK1(8), SPP1(2), STAT1(15), TBK1(7), TICAM1(5), TIRAP(2), TLR1(15), TLR2(16), TLR3(10), TLR4(17), TLR5(14), TLR6(14), TLR7(17), TLR8(18), TLR9(6), TOLLIP(1), TRAF3(5), TRAF6(7)	31810954	851	209	718	173	196	276	194	5	164	16	3.94e-07	0.707	1.000
99	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(8), IFNG(10), IL12A(5), IL12B(2), IL18(2), IL2(2)	1135018	29	20	28	7	9	9	5	1	5	0	0.350	0.717	1.000
100	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	ACVR1(8), APC(56), ATF2(8), AXIN1(9), BMP10(9), BMP2(6), BMP4(10), BMP5(14), BMP7(12), BMPR1A(5), BMPR2(12), CHRD(12), CTNNB1(80), DVL1(3), FZD1(3), GATA4(3), GSK3B(13), MAP3K7(9), MEF2C(10), MYL2(2), NKX2-5(2), NOG(2), NPPA(2), NPPB(2), RFC1(21), TGFB1(1), TGFB2(5), TGFB3(9), TGFBR1(6), TGFBR2(6), TGFBR3(15), WNT1(1)	12863550	356	130	293	73	89	168	52	3	41	3	0.000305	0.721	1.000
101	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(6), ALDOA(5), ALDOB(9), ALDOC(3), TPI1(2)	1409129	25	16	24	4	8	5	5	0	7	0	0.0994	0.744	1.000
102	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(17), BMPR1A(5), BMPR1B(6), BMPR2(12)	2246825	40	22	40	5	13	14	7	2	4	0	0.0361	0.760	1.000
103	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(5), ASPH(11), COPS5(5), CREB1(5), EDN1(4), EP300(32), EPO(3), HIF1A(16), JUN(1), LDHA(6), NOS3(11), P4HB(5), VHL(3)	6084806	107	47	106	16	31	30	24	2	20	0	0.00109	0.796	1.000
104	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCR3(4), CD4(6), HLA-DRA(1), IL1B(2), IL4(1), IL5(2), IL5RA(9), IL6(5)	1844183	30	21	28	8	3	13	3	0	11	0	0.280	0.813	1.000
105	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(5), CCNE1(6), CDK2(2), CUL1(13), E2F1(9), RB1(26), SKP2(6), TFDP1(13)	3172824	80	38	78	18	27	21	17	0	12	3	0.0491	0.851	1.000
106	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(8), SUCLA2(5)	775051	13	10	11	3	8	3	0	0	2	0	0.299	0.853	1.000
107	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCL5(2), CCR3(4), CSF2(1), HLA-DRA(1), IL3(2), IL5(2)	970363	12	11	12	1	3	4	2	0	3	0	0.0945	0.867	1.000
108	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	AKR1B10(4), DHRS1(3), DHRS2(3), DHRS3(2), DHRS7(6), DHRSX(2), HSD3B7(5), PON1(12), PON2(6), PON3(5), RDH11(1), RDH12(5), RDH13(4), RDH14(2)	3235853	60	31	58	11	19	21	10	1	9	0	0.0142	0.880	1.000
109	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(1), FDPS(8), IDI1(3), SQLE(5)	1213914	17	12	17	2	4	8	4	0	1	0	0.167	0.885	1.000
110	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(7), COASY(11), DPYD(20), DPYS(6), ENPP1(12), ENPP3(17), PANK1(3), PANK2(7), PANK3(5), PANK4(5), PPCS(4), UPB1(10)	4910957	107	38	106	21	26	43	26	0	12	0	0.0140	0.904	1.000
111	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(32), EP300(32), ESR1(11), MAPK1(2), MAPK3(3), PELP1(9), SRC(3)	5444727	92	47	87	19	26	21	25	1	18	1	0.0389	0.920	1.000
112	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(2), ADH1B(5), ADH4(4), ADH6(9), ADH7(4), ADHFE1(5)	2104861	29	19	29	6	11	5	7	0	6	0	0.109	0.933	1.000
113	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	41	APAF1(17), BAK1(3), BAX(2), BCL2L1(4), BID(2), BIRC2(10), BIRC3(5), CASP2(6), CASP3(4), CASP6(7), CASP7(1), CASP8(21), CASP9(3), CYCS(2), FADD(1), FAS(8), FASLG(7), GZMB(4), IKBKG(3), JUN(1), MAP2K4(9), MAP3K1(30), MAPK10(10), MCL1(1), MDM2(5), MYC(8), NFKB1(10), NFKBIA(3), PARP1(9), PRF1(8), RELA(6), RIPK1(8), TNFRSF1A(4), TNFRSF1B(2), TNFSF10(1), TP53(74), TRAF1(5), TRAF2(3)	13320502	307	116	276	65	72	104	66	2	62	1	0.00136	0.944	1.000
114	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	4	CDK5(2), FOSB(4), GRIA2(21), PPP1R1B(2)	1282432	29	17	28	8	8	7	6	0	8	0	0.307	0.947	1.000
115	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	85	ABL1(8), ABL2(21), AKT1(4), AKT2(6), AKT3(11), ARAF(12), AREG(2), BAD(1), BRAF(10), BTC(2), CAMK2A(9), CAMK2B(4), CAMK2D(5), CAMK2G(5), CBL(12), CBLB(12), CBLC(5), CDKN1A(1), CDKN1B(7), CRK(2), CRKL(6), EGF(19), EGFR(12), ELK1(3), ERBB2(10), ERBB3(19), ERBB4(27), EREG(3), GAB1(7), GRB2(3), GSK3B(13), HBEGF(2), HRAS(1), JUN(1), KRAS(52), MAP2K1(2), MAP2K2(5), MAP2K4(9), MAP2K7(4), MAPK1(2), MAPK10(10), MAPK3(3), MAPK8(11), MAPK9(4), MYC(8), NCK1(4), NCK2(8), NRAS(9), NRG1(19), NRG2(4), NRG3(15), NRG4(1), PAK1(3), PAK2(3), PAK3(16), PAK6(4), PAK7(9), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(99), PIK3R2(7), PIK3R3(9), PIK3R5(10), PLCG1(12), PLCG2(27), PRKCA(11), PRKCG(8), PTK2(12), RAF1(9), RPS6KB1(3), RPS6KB2(4), SHC1(6), SHC2(5), SHC3(15), SHC4(5), SOS1(13), SOS2(17), SRC(3), STAT5A(5), STAT5B(7)	36621303	981	215	801	197	241	335	207	7	173	18	1.29e-08	0.954	1.000
116	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD28(3), CD4(6), HLA-DRA(1)	743572	10	10	10	4	2	5	0	0	3	0	0.743	0.955	1.000
117	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA1(1), NDUFA10(6), NDUFA4(1), NDUFA5(1), NDUFA8(5), NDUFB7(3), NDUFS1(13), NDUFS2(7), NDUFV1(3), NDUFV2(2)	2599039	42	26	41	8	18	10	5	1	7	1	0.116	0.959	1.000
118	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	78	ABL1(8), ACTN1(9), ACTR2(6), ACTR3(1), AKT1(4), AKT2(6), AKT3(11), ANGPTL2(6), ARHGEF6(25), ARHGEF7(15), BCAR1(8), BRAF(10), CAV1(2), CDC42(3), CDKN2A(1), CRK(2), CSE1L(14), DOCK1(21), EPHB2(11), FYN(5), GRB2(3), GRB7(4), ILK(5), ITGA1(17), ITGA10(9), ITGA11(7), ITGA2(19), ITGA3(4), ITGA4(10), ITGA5(10), ITGA6(12), ITGA7(14), ITGA8(19), ITGA9(16), ITGB3BP(5), MAP2K4(9), MAP2K7(4), MAP3K11(5), MAPK1(2), MAPK10(10), MAPK8(11), MAPK8IP1(4), MAPK8IP2(1), MAPK8IP3(9), MAPK9(4), MRAS(2), MYLK(14), MYLK2(8), P4HB(5), PAK1(3), PAK2(3), PAK3(16), PAK6(4), PAK7(9), PIK3CA(172), PIK3CB(17), PKLR(6), PLCG1(12), PLCG2(27), PTEN(227), PTK2(12), RAF1(9), RALA(6), RHO(4), ROCK1(22), ROCK2(17), SHC1(6), SOS1(13), SOS2(17), SRC(3), TERF2IP(2), TLN1(23), TLN2(29), VASP(3), WAS(11), ZYX(11)	44169711	1094	216	882	229	244	323	222	39	232	34	4.85e-09	0.964	1.000
119	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	17	DNAJA3(5), IFNG(10), IFNGR1(4), IFNGR2(4), IKBKB(13), JAK2(17), LIN7A(8), NFKB1(10), NFKBIA(3), RB1(26), RELA(6), TNFRSF1A(4), TNFRSF1B(2), TP53(74), USH1C(5), WT1(3)	6411700	194	94	169	44	53	62	36	2	35	6	0.0294	0.966	1.000
120	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(14), GABRA2(13), GABRA3(14), GABRA4(19), GABRA5(10), GABRA6(8), PRKCE(10), SOD1(2)	2901805	90	35	85	26	23	36	18	0	13	0	0.198	0.967	1.000
121	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(1), RANBP1(2), RANBP2(40), RANGAP1(3)	3100037	46	23	46	8	10	18	10	0	8	0	0.159	0.967	1.000
122	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	22	ATM(54), ATR(38), BRCA1(17), CCNB1(8), CDC25A(8), CDC25B(3), CDC25C(5), CDKN1A(1), CDKN2D(1), CHEK1(2), CHEK2(13), EP300(32), MDM2(5), MYT1(18), PRKDC(54), RPS6KA1(1), TP53(74), WEE1(2), YWHAH(3), YWHAQ(1)	15904811	340	118	307	63	74	103	82	4	73	4	0.000910	0.967	1.000
123	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	20	BAD(1), BAX(2), CASP8(21), CYCS(2), FADD(1), MAP2K1(2), MAP2K4(9), MAP3K1(30), MAPK1(2), MAPK3(3), MAPK8(11), NFKB1(10), NSMAF(9), RAF1(9), RELA(6), RIPK1(8), SMPD1(4), TNFRSF1A(4), TRAF2(3)	7275526	137	49	133	29	27	47	27	0	35	1	0.0363	0.972	1.000
124	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	ASAH1(6), BFAR(7), BRAF(10), CAMP(1), CREB1(5), CREB5(5), MAPK1(2), RAF1(9), SNX13(15), SRC(3), TERF2IP(2)	4244786	65	28	64	12	14	25	14	1	11	0	0.0720	0.980	1.000
125	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	9	BAG4(5), BIRC3(5), CASP8(21), FADD(1), RIPK1(8), TNFRSF1A(4), TNFRSF1B(2), TRAF2(3)	2704555	49	29	47	12	9	17	9	0	14	0	0.205	0.983	1.000
126	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(54), CDC25A(8), CDC25B(3), CDC25C(5), CHEK1(2), MYT1(18), WEE1(2), YWHAH(3)	5100102	95	37	90	16	22	33	17	0	20	3	0.0368	0.986	1.000
127	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(3), FOSL1(3), FOSL2(7), IFNAR1(7), IFNAR2(8), IFNB1(3), MAPK8(11), NFKB1(10), RELA(6), TNFRSF11A(4), TNFSF11(7), TRAF6(7)	3947890	76	31	74	13	19	24	21	0	12	0	0.0149	0.987	1.000
128	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CCR5(6), CD3D(6), CD3E(2), CD3G(3), CXCR3(5), ETV5(3), IFNG(10), IL12A(5), IL12B(2), IL12RB1(13), IL12RB2(10), IL18(2), IL18R1(9), JAK2(17), JUN(1), MAP2K6(10), MAPK14(4), MAPK8(11), STAT4(7), TYK2(10)	6885170	136	42	134	28	28	50	31	1	23	3	0.0180	0.987	1.000
129	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CSF2(1), CSF3(1), EPO(3), FLT3(16), IGF1(5), IL11(2), IL3(2), IL6(5), IL9(1), KITLG(3), TGFB1(1), TGFB2(5), TGFB3(9)	3069442	54	29	52	12	13	21	10	0	10	0	0.108	0.988	1.000
130	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	ATP6V0C(1), GGT1(5), SHMT1(5), SHMT2(5)	1518951	16	13	16	3	7	5	2	0	2	0	0.154	0.990	1.000
131	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNA1(2), IFNB1(3), IFNG(10), IL10(4), IL12A(5), IL12B(2), IL15(2), IL16(16), IL18(2), IL2(2), IL3(2), IL4(1), IL5(2), IL6(5), IL9(1), LTA(3)	3525903	62	27	61	16	15	25	11	1	10	0	0.114	0.990	1.000
132	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(19), EGFR(12), ERBB3(19), NRG1(19)	3749909	69	32	66	14	18	24	14	0	13	0	0.0975	0.991	1.000
133	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(7), PGLYRP2(4)	631323	11	9	10	7	2	6	0	0	3	0	0.959	0.991	1.000
134	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(8), CDC25B(3), CDK7(7), CDKN1A(1), CHEK1(2), NEK1(19), WEE1(2)	2797504	42	22	40	7	14	17	4	0	7	0	0.159	0.991	1.000
135	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(32), EP300(32), LPL(16), NCOA1(19), NCOA2(15), PPARG(6), RXRA(3)	6718199	123	50	119	26	31	36	31	2	22	1	0.0251	0.992	1.000
136	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(4), GPLD1(12), PGAP1(17), PIGA(8), PIGB(11), PIGC(3), PIGF(2), PIGG(6), PIGH(5), PIGK(9), PIGL(1), PIGM(1), PIGN(13), PIGO(9), PIGP(3), PIGQ(5), PIGS(1), PIGT(8), PIGU(2), PIGV(7), PIGW(9), PIGX(2), PIGZ(5)	8968278	143	49	140	25	36	55	34	0	18	0	0.000637	0.993	1.000
137	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(7), F13A1(8), F2(8), F2R(6), FGA(26), FGB(7), FGG(9), PLAT(6), PLG(14), SERPINB2(9), SERPINE1(5)	4979506	105	36	101	23	22	46	24	1	12	0	0.0358	0.994	1.000
138	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(6), CYP2C9(5)	748071	11	8	11	4	3	6	0	0	2	0	0.762	0.994	1.000
139	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(4), BCKDK(5), CBS(11), CTH(6), MUT(10)	1755891	36	21	35	9	10	15	5	0	6	0	0.259	0.996	1.000
140	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(10), ALDH1A2(11), RDH5(3)	1414742	24	13	24	9	6	8	4	0	6	0	0.644	0.997	1.000
141	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(3), LIPT1(5)	566294	8	7	8	4	2	3	2	0	1	0	0.924	0.998	1.000
142	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(1), SEC61A2(3), SRP19(3), SRP54(8), SRP68(5), SRP72(11), SRP9(1), SRPR(11)	2776480	43	21	43	8	10	21	6	0	6	0	0.182	0.998	1.000
143	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	AOC2(7), AOC3(10), CES1(13), ESD(2)	2112292	32	19	29	7	9	11	9	0	3	0	0.159	0.998	1.000
144	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(9), GAD1(6), HDC(9), PNMT(2), TH(3), TPH1(9)	2023477	38	23	37	10	14	11	8	0	4	1	0.202	0.999	1.000
145	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(18), CD38(6), ENPP1(12), ENPP3(17), NADSYN1(6), NMNAT1(3), NMNAT2(3), NNMT(6), NNT(7), NT5C(1), NT5E(6), NT5M(2), QPRT(2)	5305520	89	31	87	20	21	37	27	0	4	0	0.0385	0.999	1.000
146	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(6), CD8A(2), CSF1(6), CSF2(1), CSF3(1), EPO(3), IL11(2), IL2(2), IL3(2), IL4(1), IL5(2), IL6(5), IL7(1), IL9(1)	2235970	35	29	35	11	8	14	4	1	8	0	0.374	0.999	1.000
147	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	FABP6(3), LDLR(7), NR0B2(2), NR1H3(4), NR1H4(7), RXRA(3)	1864144	26	18	26	6	9	6	4	1	6	0	0.193	0.999	1.000
148	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCNA1(5), CCNB1(8), CCND1(14), CCND2(9), CCND3(4), CCNE1(6), CCNH(7), CDC25A(8), CDK2(2), CDK4(2), CDK6(3), CDK7(7), CDKN1A(1), CDKN1B(7), CDKN2A(1), CDKN2C(4), CDKN2D(1), E2F1(9), RB1(26), RBL1(13), TFDP1(13)	5680949	150	55	144	32	43	42	30	0	32	3	0.0185	0.999	1.000
149	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNA1(2), IFNAR1(7), IFNAR2(8), IFNB1(3), JAK1(20), STAT1(15), STAT2(8), TYK2(10)	3919832	73	30	71	20	21	20	20	0	12	0	0.256	1.000	1.000
150	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(8), CCNH(7), CDC25A(8), CDC25B(3), CDC25C(5), CDK7(7), SHH(4), XPO1(18)	3154343	60	25	57	12	24	15	12	0	9	0	0.0956	1.000	1.000
151	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYA(9), NFYB(2), NFYC(3), RB1(26), SP1(7), SP3(10)	2477280	57	27	54	11	16	14	13	0	11	3	0.146	1.000	1.000
152	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(9), ENO1(6), GPI(7), HK1(11), PFKL(8), PGAM1(3), PGK1(7), PKLR(6), TPI1(2)	3222973	59	30	58	14	22	21	8	0	8	0	0.0560	1.000	1.000
153	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(1), FDPS(8), GGPS1(2), IDI1(3), IDI2(1), SQLE(5)	1613940	20	13	20	5	5	10	4	0	1	0	0.474	1.000	1.000
154	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(11), CYP2A13(9), CYP2A6(13), CYP2A7(6), NAT1(7), NAT2(4), XDH(14)	2966743	64	35	60	17	19	30	8	0	7	0	0.117	1.000	1.000
155	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	16	ADAM10(4), ANKRD1(7), ATF3(3), CYR61(3), DUSP14(4), EIF4E(1), HBEGF(2), IFNG(10), IFRD1(6), IL18(2), IL1R1(5), MYOG(1), NR4A3(8), WDR1(7)	3908198	63	27	63	15	16	25	11	0	11	0	0.195	1.000	1.000
156	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(5), CR1(22), CR2(22), FCGR2B(3), HLA-DRA(1), ICAM1(2), ITGAL(17), ITGB2(15), PTPRC(17)	5411848	104	38	103	29	30	38	17	1	17	1	0.121	1.000	1.000
157	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GSR(6), GSS(5), NFKB1(10), NOX1(16), RELA(6), SOD1(2), XDH(14)	3588806	59	26	59	13	15	21	13	1	9	0	0.106	1.000	1.000
158	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(6), ACAT2(4), BDH1(3), BDH2(4), HMGCL(2), HMGCS1(6), HMGCS2(9), OXCT1(10), OXCT2(2)	2682095	46	25	45	11	14	17	8	1	6	0	0.203	1.000	1.000
159	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(17), ARHGAP5(21), ARHGDIB(3), CASP1(8), CASP10(8), CASP3(4), CASP8(21), CASP9(3), CYCS(2), GZMB(4), JUN(1), PRF1(8)	4727581	100	34	96	25	21	36	20	0	22	1	0.241	1.000	1.000
160	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD28(3), CD86(5), HLA-DRA(1), IFNG(10), IFNGR1(4), IFNGR2(4), IL12A(5), IL12B(2), IL12RB1(13), IL12RB2(10), IL18(2), IL18R1(9), IL2(2), IL2RA(4), IL4(1), IL4R(6)	4551927	81	32	80	25	27	28	14	1	11	0	0.266	1.000	1.000
161	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM1(2), CALM2(3), CAMK1(3), CAMK1G(5), CAMK2A(9), CAMK2B(4), CAMK2D(5), CAMK2G(5), CAMK4(5), CAMKK1(11), CAMKK2(6), CREB1(5), SYT1(4)	4149292	67	29	66	15	24	24	9	0	10	0	0.0383	1.000	1.000
162	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CCR5(6), CD2(4), CD3D(6), CD3E(2), CD3G(3), CD4(6), CXCR3(5), IFNG(10), IL12A(5), IL12B(2), IL12RB1(13), IL12RB2(10), JAK2(17), STAT4(7), TYK2(10)	5451266	106	38	105	29	21	48	17	1	16	3	0.231	1.000	1.000
163	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	19	B3GNT1(5), B3GNT2(1), B3GNT3(5), B3GNT4(4), B3GNT5(6), B4GALT1(2), B4GALT2(5), B4GALT3(10), B4GALT4(5), FUT1(4), FUT2(1), FUT3(8), FUT5(1), FUT6(10), FUT7(2), FUT9(9), GCNT2(4), ST3GAL6(6), ST8SIA1(2)	5116187	90	36	89	21	39	28	12	1	10	0	0.0309	1.000	1.000
164	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	126	ARAF(12), BID(2), BRAF(10), CASP3(4), CD244(6), CD247(5), CD48(2), CSF2(1), FAS(8), FASLG(7), FCER1G(2), FCGR3A(1), FYN(5), GRB2(3), GZMB(4), HCST(1), HLA-A(1), HLA-B(2), HLA-C(2), HLA-E(1), HLA-G(2), HRAS(1), ICAM1(2), ICAM2(3), IFNA1(2), IFNA10(3), IFNA13(3), IFNA14(4), IFNA16(3), IFNA17(3), IFNA2(2), IFNA21(1), IFNA4(3), IFNA5(5), IFNA6(2), IFNA7(1), IFNA8(3), IFNAR1(7), IFNAR2(8), IFNB1(3), IFNG(10), IFNGR1(4), IFNGR2(4), ITGAL(17), ITGB2(15), KIR2DL3(1), KIR3DL1(10), KIR3DL2(5), KLRC1(7), KLRC2(1), KLRC3(2), KLRD1(3), KLRK1(1), KRAS(52), LCK(4), LCP2(5), MAP2K1(2), MAP2K2(5), MAPK1(2), MAPK3(3), MICA(1), MICB(2), NCR1(6), NCR2(3), NFAT5(16), NFATC1(10), NFATC2(13), NFATC3(11), NFATC4(5), NRAS(9), PAK1(3), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(99), PIK3R2(7), PIK3R3(9), PIK3R5(10), PLCG1(12), PLCG2(27), PPP3CA(4), PPP3CB(6), PPP3CC(6), PPP3R1(1), PRF1(8), PRKCA(11), PRKCG(8), PTK2B(15), PTPN11(8), PTPN6(5), RAC1(1), RAC2(2), RAF1(9), SH2D1A(7), SH2D1B(4), SH3BP2(7), SHC1(6), SHC2(5), SHC3(15), SHC4(5), SOS1(13), SOS2(17), SYK(4), TNFRSF10A(2), TNFRSF10B(5), TNFRSF10C(4), TNFRSF10D(6), TNFSF10(1), TYROBP(1), ULBP1(2), ULBP2(5), ULBP3(1), VAV1(12), VAV2(7), VAV3(13), ZAP70(8)	40242749	994	212	813	225	243	350	215	7	162	17	1.36e-06	1.000	1.000
165	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(10), IFNGR1(4), IFNGR2(4), JAK1(20), JAK2(17), STAT1(15)	3049904	70	31	69	21	19	21	13	0	14	3	0.472	1.000	1.000
166	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	73	CALM1(2), CALM2(3), CALML3(3), CALML6(4), CDS1(5), DGKA(9), DGKB(23), DGKD(18), DGKE(5), DGKG(11), DGKH(10), DGKI(18), DGKQ(2), DGKZ(10), FN3K(5), IMPA1(3), IMPA2(6), INPP1(3), INPP4A(19), INPP4B(16), INPP5A(4), INPP5B(5), INPP5D(9), INPP5E(1), INPPL1(18), ITPK1(4), ITPKA(1), ITPKB(11), ITPR1(34), ITPR2(35), ITPR3(22), OCRL(19), PI4KA(17), PI4KB(9), PIK3C2A(22), PIK3C2B(10), PIK3C2G(16), PIK3C3(14), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(99), PIK3R2(7), PIK3R3(9), PIK3R5(10), PIP4K2A(5), PIP4K2B(7), PIP4K2C(3), PIP5K1A(8), PIP5K1B(5), PIP5K1C(6), PLCB1(5), PLCB2(8), PLCB3(11), PLCB4(19), PLCD1(4), PLCD3(3), PLCD4(10), PLCE1(39), PLCG1(12), PLCG2(27), PLCZ1(13), PRKCA(11), PRKCG(8), PTEN(227), PTPMT1(2), SYNJ1(29), SYNJ2(11)	45436750	1248	223	1021	279	292	339	249	42	281	45	4.19e-06	1.000	1.000
167	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(4), CD28(3), CD3D(6), CD3E(2), CD3G(3), CD4(6), ICAM1(2), ITGAL(17), ITGB2(15), PTPRC(17), THY1(1)	4083120	76	36	75	24	20	31	9	0	16	0	0.270	1.000	1.000
168	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	38	ANAPC1(21), ANAPC10(2), ANAPC2(6), ANAPC4(5), ANAPC5(8), ANAPC7(5), BTRC(14), CDC16(11), CDC20(4), CDC23(5), CUL1(13), CUL2(12), CUL3(14), FBXW11(5), FBXW7(44), FZR1(2), ITCH(10), RBX1(1), SKP2(6), SMURF1(12), SMURF2(8), TCEB1(2), TCEB2(2), UBA1(17), UBE2C(1), UBE2D2(4), UBE2D3(2), UBE2D4(2), UBE2E1(4), UBE2E2(3), UBE2E3(6), VHL(3), WWP1(19), WWP2(9)	14140270	282	91	262	57	88	87	58	2	45	2	0.00215	1.000	1.000
169	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(2), IFNG(10), IFNGR1(4), JAK1(20), JAK2(17), PTPRU(17), REG1A(4), STAT1(15)	4199450	89	36	88	24	31	25	14	0	16	3	0.219	1.000	1.000
170	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(9), ELK1(3), EPO(3), EPOR(4), FOS(3), GRB2(3), HRAS(1), JAK2(17), JUN(1), MAP2K1(2), MAPK3(3), MAPK8(11), PLCG1(12), PTPN6(5), RAF1(9), SHC1(6), SOS1(13), STAT5A(5), STAT5B(7)	7811814	117	48	110	26	32	45	26	0	11	3	0.0319	1.000	1.000
171	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(3), CD3D(6), CD3E(2), CD3G(3), GZMB(4), HLA-A(1), ICAM1(2), ITGAL(17), ITGB2(15), PRF1(8)	3051150	61	32	59	18	24	22	4	0	11	0	0.0811	1.000	1.000
172	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3D(6), CD3E(2), CD3G(3), CD4(6), FYN(5), HLA-DRA(1), LCK(4), PTPRC(17), ZAP70(8)	3156865	52	25	52	14	11	21	7	0	13	0	0.264	1.000	1.000
173	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(2), JAK1(20), JAK2(17), JAK3(10), PIAS1(7), PIAS3(9), PTPRU(17), REG1A(4), SOAT1(9)	5010873	95	37	94	25	28	32	17	1	14	3	0.175	1.000	1.000
174	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(6), CHRNA1(7), SNAP25(7), STX1A(1)	1177188	21	14	20	6	11	2	6	0	2	0	0.395	1.000	1.000
175	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(6), ENO2(4), ENO3(5), FARS2(2), GOT1(9), GOT2(3), PAH(2), TAT(7), YARS(5)	3043413	43	21	43	11	14	14	10	1	4	0	0.248	1.000	1.000
176	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	CISH(2), IL6(5), IL6R(7), JAK1(20), JAK2(17), JAK3(10), PIAS3(9), PTPRU(17), REG1A(4), SRC(3), STAT3(11)	5492541	105	41	104	28	27	35	21	1	18	3	0.148	1.000	1.000
177	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(5), RAB11A(2), RAB1A(5), RAB27A(3), RAB3A(3), RAB4A(5), RAB5A(2), RAB6A(1), RAB9A(6)	1589158	32	17	30	10	13	8	5	0	6	0	0.326	1.000	1.000
178	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(4), ARG1(5), GLS(11), GLUD1(3), OAT(7), PRODH(10)	2002359	40	21	37	12	12	13	7	1	7	0	0.397	1.000	1.000
179	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(14), FOS(3), GRB2(3), HRAS(1), IL3(2), IL3RA(9), JAK2(17), MAP2K1(2), MAPK3(3), PTPN6(5), RAF1(9), SHC1(6), SOS1(13), STAT5A(5), STAT5B(7)	6359638	99	43	95	26	29	42	20	0	5	3	0.134	1.000	1.000
180	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(7), CLOCK(9), CRY1(9), CRY2(3), CSNK1D(3), CSNK1E(3), NPAS2(13), NR1D1(4), PER1(10), PER2(13), PER3(15)	6067688	89	40	85	22	30	34	14	1	10	0	0.0646	1.000	1.000
181	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	6	B3GNT1(5), FUT1(4), FUT2(1), FUT9(9), GCNT2(4), ST8SIA1(2)	1973787	25	15	25	8	13	6	5	0	1	0	0.321	1.000	1.000
182	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(4), CD28(3), CD3D(6), CD3E(2), CD3G(3), CD8A(2), ICAM1(2), ITGAL(17), ITGB2(15), PTPRC(17), THY1(1)	3842727	72	32	71	23	22	28	9	0	13	0	0.241	1.000	1.000
183	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5E(2), ATP5O(1), ATP6AP1(7), ATP6V0A1(8), ATP6V0A4(11), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(7), ATP6V1B1(12), ATP6V1B2(7), ATP6V1C1(4), ATP6V1C2(12), ATP6V1D(3), ATP6V1E1(6), ATP6V1F(2), ATP6V1G1(2), ATP6V1G2(2), ATP6V1G3(2), ATP6V1H(7), SHMT1(5)	5607042	105	43	103	28	26	39	13	0	26	1	0.179	1.000	1.000
184	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5E(2), ATP5O(1), ATP6AP1(7), ATP6V0A1(8), ATP6V0A4(11), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(7), ATP6V1B1(12), ATP6V1B2(7), ATP6V1C1(4), ATP6V1C2(12), ATP6V1D(3), ATP6V1E1(6), ATP6V1F(2), ATP6V1G1(2), ATP6V1G2(2), ATP6V1G3(2), ATP6V1H(7), SHMT1(5)	5607042	105	43	103	28	26	39	13	0	26	1	0.179	1.000	1.000
185	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5E(2), ATP5O(1), ATP6AP1(7), ATP6V0A1(8), ATP6V0A4(11), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(7), ATP6V1B1(12), ATP6V1B2(7), ATP6V1C1(4), ATP6V1C2(12), ATP6V1D(3), ATP6V1E1(6), ATP6V1F(2), ATP6V1G1(2), ATP6V1G2(2), ATP6V1G3(2), ATP6V1H(7), SHMT1(5)	5607042	105	43	103	28	26	39	13	0	26	1	0.179	1.000	1.000
186	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	20	CSNK2A1(9), ELK1(3), FOS(3), GRB2(3), HRAS(1), IL6(5), IL6R(7), IL6ST(11), JAK1(20), JAK2(17), JAK3(10), JUN(1), MAP2K1(2), MAPK3(3), PTPN11(8), RAF1(9), SHC1(6), SOS1(13), SRF(3), STAT3(11)	8536621	145	55	139	32	31	55	35	0	21	3	0.0296	1.000	1.000
187	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	NRF1(5), TAX1BP3(1), UBE2A(3), UBE2B(3), UBE2C(1), UBE2D2(4), UBE2D3(2), UBE2E1(4), UBE2E3(6), UBE2G1(2), UBE2H(1), UBE2J1(2), UBE2L3(2), UBE2L6(3), UBE2N(4), UBE3A(16)	3762990	59	28	59	15	15	14	15	2	13	0	0.206	1.000	1.000
188	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAD(3), ALAS1(8), ALAS2(10), CPO(3), FECH(7), GATA1(8), HBA1(1), HBA2(1), HBB(2), HMBS(8), UROD(3), UROS(3)	3008529	57	27	55	15	19	22	10	0	6	0	0.235	1.000	1.000
189	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(21), ADRB2(7), CFTR(14), GNAS(24), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), SLC9A3R1(2)	4521301	95	36	91	26	38	27	15	1	13	1	0.139	1.000	1.000
190	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP5E(2), ATP5O(1), ATP6AP1(7), ATP6V0A1(8), ATP6V0A4(11), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(7), ATP6V1B1(12), ATP6V1B2(7), ATP6V1C1(4), ATP6V1C2(12), ATP6V1D(3), ATP6V1E1(6), ATP6V1F(2), ATP6V1G1(2), ATP6V1G2(2), ATP6V1G3(2), ATP6V1H(7), FDXR(2), SHMT1(5)	5871170	107	43	105	28	27	39	14	0	26	1	0.150	1.000	1.000
191	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(7), ACOX3(8), FADS2(2), PLA2G12A(1), PLA2G12B(4), PLA2G2D(2), PLA2G2E(5), PLA2G2F(3), PLA2G3(7), PLA2G4A(13), PLA2G5(1), PLA2G6(9)	3783753	62	33	59	18	25	18	5	2	12	0	0.187	1.000	1.000
192	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(7), IARS(8), LARS(18), LARS2(8), PDHA1(7), PDHA2(9), PDHB(3)	3714074	60	23	59	14	10	28	9	0	13	0	0.347	1.000	1.000
193	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(14), AGT(8), AGTR1(4), AGTR2(11), BDKRB2(8), KNG1(11), NOS3(11), REN(4)	3394668	71	29	68	20	31	28	6	1	5	0	0.0819	1.000	1.000
194	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	14	ACTA1(5), APAF1(17), CASP3(4), CASP9(3), CYCS(2), DAXX(9), FAS(8), FASLG(7), HSPB2(1), MAPKAPK2(5), MAPKAPK3(5)	3917860	66	27	65	16	15	24	17	0	10	0	0.186	1.000	1.000
195	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALT(3), TGDS(4), UGDH(2), UGP2(6), UXS1(5)	1872620	20	15	19	7	6	7	5	0	2	0	0.734	1.000	1.000
196	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	11	APAF1(17), BAD(1), BAK1(3), BAX(2), BCL10(3), BCL2L1(4), BCL2L11(6), BID(2), CASP9(3), CES1(13)	2783428	54	26	53	13	9	21	16	0	8	0	0.263	1.000	1.000
197	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(22), C5(18), C6(16), C7(20), C8A(9), C9(19)	4725130	104	33	99	27	21	45	23	0	13	2	0.219	1.000	1.000
198	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(2), MTMR1(16), MTMR2(5), MTMR6(10), NFS1(5), PHPT1(1), TPK1(3)	2334275	42	20	41	10	10	17	7	0	8	0	0.397	1.000	1.000
199	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(2), FARSA(6), FARSB(7), GOT1(9), GOT2(3), PAH(2), TAT(7), YARS(5), YARS2(3)	3194444	44	24	44	12	15	14	11	1	3	0	0.324	1.000	1.000
200	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(7), CLOCK(9), CRY1(9), CRY2(3), CSNK1E(3), PER1(10)	3037182	41	24	40	10	12	17	6	1	5	0	0.298	1.000	1.000
201	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(3), ACP2(1), ACP5(5), ACPP(6), ACPT(5), ENPP1(12), ENPP3(17), FLAD1(4), RFK(1), TYR(12)	3572293	66	25	66	15	9	26	25	0	6	0	0.203	1.000	1.000
202	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ3(5), COQ5(1), COQ6(4), COQ7(3), NDUFA13(1), NDUFB11(3)	1527536	17	15	17	8	8	5	2	0	2	0	0.847	1.000	1.000
203	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	IMPA1(3), INPP1(3), INPP4A(19), INPP4B(16), INPP5A(4), INPPL1(18), ITPKA(1), ITPKB(11), MIOX(5), OCRL(19), PIK3C2A(22), PIK3C2B(10), PIK3C2G(16), PIK3CA(172), PIK3CB(17), PIK3CG(23), PLCB1(5), PLCB2(8), PLCB3(11), PLCB4(19), PLCD1(4), PLCG1(12), PLCG2(27)	16343503	445	161	341	101	125	139	116	5	59	1	0.00207	1.000	1.000
204	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	93	AKT1(4), AKT2(6), AKT3(11), BCL10(3), CARD11(22), CBL(12), CBLB(12), CBLC(5), CD247(5), CD28(3), CD3D(6), CD3E(2), CD3G(3), CD4(6), CD40LG(6), CD8A(2), CD8B(1), CDC42(3), CDK4(2), CHUK(8), CSF2(1), CTLA4(2), FOS(3), FYN(5), GRB2(3), HRAS(1), ICOS(3), IFNG(10), IKBKB(13), IKBKG(3), IL10(4), IL2(2), IL4(1), IL5(2), ITK(7), JUN(1), KRAS(52), LCK(4), LCP2(5), MALT1(4), MAP3K8(10), NCK1(4), NCK2(8), NFAT5(16), NFATC1(10), NFATC2(13), NFATC3(11), NFATC4(5), NFKB1(10), NFKB2(9), NFKBIA(3), NFKBIB(1), NFKBIE(6), NRAS(9), PAK1(3), PAK2(3), PAK3(16), PAK6(4), PAK7(9), PDCD1(3), PDK1(2), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(99), PIK3R2(7), PIK3R3(9), PIK3R5(10), PLCG1(12), PPP3CA(4), PPP3CB(6), PPP3CC(6), PPP3R1(1), PRKCQ(9), PTPN6(5), PTPRC(17), RASGRP1(8), RHOA(3), SOS1(13), SOS2(17), TEC(7), VAV1(12), VAV2(7), VAV3(13), ZAP70(8)	36166709	900	211	723	203	217	299	195	10	162	17	6.34e-05	1.000	1.000
205	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	19	APAF1(17), BAK1(3), BAX(2), BCL2L1(4), BID(2), BIK(2), BIRC2(10), BIRC3(5), CASP3(4), CASP6(7), CASP7(1), CASP8(21), CASP9(3), CYCS(2), DFFB(4), DIABLO(3), ENDOG(1)	4938447	91	33	88	24	15	35	19	0	22	0	0.360	1.000	1.000
206	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(22), AGT(8), AGTR1(4), AGTR2(11), CMA1(2), COL4A1(21), COL4A2(14), COL4A3(25), COL4A4(23), COL4A5(26), COL4A6(31), REN(4)	9494645	191	50	185	46	41	98	23	2	23	4	0.0224	1.000	1.000
207	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(3), ECHS1(3), HADH(1), HADHA(5), HADHB(4), HSD17B10(4), HSD17B4(12), MECR(5), PPT1(3), PPT2(1)	3035384	41	26	40	12	7	15	14	1	4	0	0.438	1.000	1.000
208	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(6), HLCS(6), SPCS3(2)	1133663	14	10	14	9	2	3	8	0	1	0	0.967	1.000	1.000
209	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	9	ALDOA(5), CTSD(4), ESR1(11), GREB1(19), HSPB2(1), MTA1(6), MTA3(6), PDZK1(5), TUBA8(7)	3584758	64	38	63	18	21	16	16	3	8	0	0.164	1.000	1.000
210	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(10), GALNT10(8), GALNT2(10), GALNT3(8), GALNT4(8), GALNT6(1), GALNT7(12), GALNT8(11), GALNT9(8), GCNT1(5), ST3GAL1(2), ST3GAL2(6), ST3GAL4(3), WBSCR17(15)	5377050	107	41	105	29	30	40	27	1	9	0	0.174	1.000	1.000
211	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(21), GNAS(24), GNB1(2), GNGT1(1), PRKACA(6), PRKAR1A(4)	2172411	58	29	56	15	29	14	8	0	7	0	0.211	1.000	1.000
212	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(5), ASL(2), CPS1(22), GLS(11), GLUD1(3), GOT1(9)	2808232	52	22	51	13	10	21	8	1	10	2	0.316	1.000	1.000
213	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(3), ACP2(1), ACP5(5), ACP6(4), ACPP(6), ACPT(5), ENPP1(12), ENPP3(17), FLAD1(4), LHPP(2), MTMR1(16), MTMR2(5), MTMR6(10), PHPT1(1), RFK(1), TYR(12)	5503174	104	33	103	25	17	42	31	0	14	0	0.195	1.000	1.000
214	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	ANP32A(2), APEX1(1), CREBBP(32), DFFB(4), GZMA(6), GZMB(4), HMGB2(4), NME1(2), PRF1(8), SET(7)	3880986	70	34	66	21	23	23	10	0	13	1	0.301	1.000	1.000
215	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(9), ELK1(3), FOS(3), GRB2(3), HRAS(1), IL2(2), IL2RA(4), IL2RB(3), IL2RG(11), JAK1(20), JAK3(10), JUN(1), LCK(4), MAP2K1(2), MAPK3(3), MAPK8(11), RAF1(9), SHC1(6), SOS1(13), STAT5A(5), STAT5B(7), SYK(4)	8425585	134	54	128	31	32	53	26	2	21	0	0.0221	1.000	1.000
216	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(7), CDO1(4), CSAD(5), GAD1(6), GAD2(12), GGT1(5)	2063029	39	21	39	13	8	12	10	2	7	0	0.508	1.000	1.000
217	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CSF1(6), IL1B(2), MST1R(12)	2135450	20	15	18	8	9	7	1	0	3	0	0.694	1.000	1.000
218	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREB1(5), CREM(5), FOS(3), JUN(1), MAPK3(3), OPRK1(10), POLR2A(21), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3)	4652266	75	34	73	22	30	19	14	1	10	1	0.156	1.000	1.000
219	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(6), DCN(11), FMOD(5), KERA(10), LUM(12)	1337449	44	19	40	14	14	17	7	0	6	0	0.411	1.000	1.000
220	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	150	AKT1(4), AKT2(6), AKT3(11), BCL2L1(4), CBL(12), CBLB(12), CBLC(5), CCND1(14), CCND2(9), CCND3(4), CISH(2), CLCF1(1), CNTF(3), CNTFR(4), CREBBP(32), CRLF2(5), CSF2(1), CSF2RA(10), CSF2RB(14), CSF3(1), CSF3R(7), EP300(32), EPO(3), EPOR(4), GH1(2), GH2(1), GHR(8), GRB2(3), IFNA1(2), IFNA10(3), IFNA13(3), IFNA14(4), IFNA16(3), IFNA17(3), IFNA2(2), IFNA21(1), IFNA4(3), IFNA5(5), IFNA6(2), IFNA7(1), IFNA8(3), IFNAR1(7), IFNAR2(8), IFNB1(3), IFNG(10), IFNGR1(4), IFNGR2(4), IFNK(2), IFNW1(3), IL10(4), IL10RA(4), IL10RB(6), IL11(2), IL11RA(5), IL12A(5), IL12B(2), IL12RB1(13), IL12RB2(10), IL13RA1(11), IL13RA2(7), IL15(2), IL19(2), IL2(2), IL20(9), IL20RA(4), IL21(3), IL21R(7), IL22RA1(4), IL22RA2(1), IL23A(4), IL23R(5), IL24(5), IL26(3), IL2RA(4), IL2RB(3), IL2RG(11), IL3(2), IL3RA(9), IL4(1), IL4R(6), IL5(2), IL5RA(9), IL6(5), IL6R(7), IL6ST(11), IL7(1), IL7R(12), IL9(1), IL9R(3), IRF9(4), JAK1(20), JAK2(17), JAK3(10), LEP(2), LEPR(12), LIF(3), LIFR(27), MPL(7), MYC(8), OSM(2), OSMR(13), PIAS1(7), PIAS2(14), PIAS3(9), PIAS4(5), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(99), PIK3R2(7), PIK3R3(9), PIK3R5(10), PIM1(3), PRL(9), PRLR(5), PTPN11(8), PTPN6(5), SOCS2(6), SOCS4(5), SOCS5(12), SOCS7(5), SOS1(13), SOS2(17), SPRED1(3), SPRED2(8), SPRY1(3), SPRY2(5), SPRY3(6), SPRY4(2), STAM(7), STAM2(5), STAT1(15), STAT2(8), STAT3(11), STAT4(7), STAT5A(5), STAT5B(7), STAT6(10), TPO(14), TSLP(2), TYK2(10)	52598979	1222	219	1078	275	274	415	282	11	216	24	3.71e-07	1.000	1.000
221	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	14	CHUK(8), MAPK14(4), MAPK8(11), NFKB1(10), RELA(6), TNFRSF13B(3), TNFRSF17(1), TNFSF13(3), TNFSF13B(5), TRAF2(3), TRAF3(5), TRAF5(7), TRAF6(7)	5225351	73	34	72	17	19	25	11	1	17	0	0.121	1.000	1.000
222	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(5), CDKN1A(1), EPO(3), EPOR(4), GRIN1(4), HIF1A(16), JAK2(17), NFKB1(10), NFKBIA(3), RELA(6), SOD2(3)	4546138	72	30	72	20	16	26	15	1	11	3	0.306	1.000	1.000
223	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(7), BCAT2(3), COASY(11), DPYD(20), DPYS(6), ENPP1(12), ENPP3(17), ILVBL(8), PANK1(3), PANK2(7), PANK3(5), PANK4(5), PPCDC(1), PPCS(4), UPB1(10), VNN1(9)	6157106	128	43	124	32	38	47	30	0	13	0	0.0580	1.000	1.000
224	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARF1(3), ARFGAP1(2), ARFGAP3(4), ARFGEF2(27), CLTB(6), COPA(18), GBF1(15), GPLD1(12), KDELR1(3), KDELR3(3)	5936033	93	39	91	26	34	29	17	0	12	1	0.211	1.000	1.000
225	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(21), CREM(5), FHL5(7), FSHR(15), GNAS(24), XPO1(18)	3289447	90	29	84	21	38	25	15	0	11	1	0.153	1.000	1.000
226	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	13	CHUK(8), DUSP1(2), IKBKAP(13), IKBKB(13), IKBKG(3), MAP3K1(30), NFKB1(10), NFKBIA(3), RELA(6), TNFAIP3(3), TRAF3(5), TRAF6(7)	6780716	103	37	102	24	23	41	16	0	22	1	0.140	1.000	1.000
227	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(31), CPT1A(9), LEP(2), LEPR(12), PRKAA1(8), PRKAA2(11), PRKAB1(6), PRKAB2(1), PRKAG1(3), PRKAG2(4)	5343713	87	34	84	24	22	32	14	2	16	1	0.343	1.000	1.000
228	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(7), IFNB1(3), JAK1(20), PTPRU(17), REG1A(4), STAT1(15), STAT2(8), TYK2(10)	4502550	84	34	83	25	33	22	19	0	10	0	0.256	1.000	1.000
229	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(1), DCXR(1), GUSB(5), RPE(5), UCHL1(4), UGDH(2), UGT1A1(11), UGT1A10(7), UGT1A3(2), UGT1A4(3), UGT1A5(7), UGT1A6(5), UGT1A7(7), UGT1A9(3), UGT2B15(9), UGT2B4(11)	6412129	83	30	81	19	20	40	11	1	11	0	0.0840	1.000	1.000
230	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(8), APOBEC1(7), APOBEC2(4), APOBEC3A(1), APOBEC3B(5), APOBEC3C(4), APOBEC3F(6), APOBEC3G(3), APOBEC4(5)	2713493	43	20	43	12	15	18	8	1	1	0	0.375	1.000	1.000
231	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALT(3), TGDS(4), UGDH(2), UXS1(5)	1484004	14	11	14	7	3	6	4	0	1	0	0.907	1.000	1.000
232	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ABL1(8), ACTB(3), ACTG1(6), ARHGEF2(8), ARPC5(1), CD14(2), CDC42(3), CDH1(14), CLDN1(3), CTNNB1(80), CTTN(3), EZR(4), FYN(5), HCLS1(11), ITGB1(8), KRT18(1), LY96(4), NCK1(4), NCK2(8), NCL(7), OCLN(2), PRKCA(11), RHOA(3), ROCK1(22), ROCK2(17), TLR4(17), TLR5(14), TUBA1A(9), TUBA1B(3), TUBA1C(5), TUBA3C(5), TUBA3D(4), TUBA3E(10), TUBA4A(11), TUBA8(7), TUBAL3(6), TUBB1(5), TUBB2A(2), TUBB2B(2), TUBB3(6), TUBB6(5), TUBB8(4), WAS(11), WASL(8), YWHAQ(1), YWHAZ(1)	18662298	374	127	316	99	92	169	66	4	40	3	0.00749	1.000	1.000
233	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ABL1(8), ACTB(3), ACTG1(6), ARHGEF2(8), ARPC5(1), CD14(2), CDC42(3), CDH1(14), CLDN1(3), CTNNB1(80), CTTN(3), EZR(4), FYN(5), HCLS1(11), ITGB1(8), KRT18(1), LY96(4), NCK1(4), NCK2(8), NCL(7), OCLN(2), PRKCA(11), RHOA(3), ROCK1(22), ROCK2(17), TLR4(17), TLR5(14), TUBA1A(9), TUBA1B(3), TUBA1C(5), TUBA3C(5), TUBA3D(4), TUBA3E(10), TUBA4A(11), TUBA8(7), TUBAL3(6), TUBB1(5), TUBB2A(2), TUBB2B(2), TUBB3(6), TUBB6(5), TUBB8(4), WAS(11), WASL(8), YWHAQ(1), YWHAZ(1)	18662298	374	127	316	99	92	169	66	4	40	3	0.00749	1.000	1.000
234	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(12), EIF2AK4(7), EIF2B5(5), EIF2S1(2), EIF2S2(9), EIF2S3(6), EIF5(3), GSK3B(13), PPP1CA(2)	4163661	59	28	56	14	17	19	5	3	15	0	0.297	1.000	1.000
235	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(7), BCAT2(3), IARS(8), IARS2(20), ILVBL(8), LARS(18), LARS2(8), PDHA1(7), PDHA2(9), PDHB(3), VARS(6), VARS2(1)	5974162	98	33	95	25	30	36	15	0	17	0	0.242	1.000	1.000
236	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(56), AXIN1(9), CREBBP(32), CTNNB1(80), DVL1(3), EP300(32), FZD1(3), GSK3B(13), HDAC1(5), LDB1(5), LEF1(8), PITX2(8), TRRAP(41), WNT1(1)	11871781	296	124	232	78	62	130	50	5	44	5	0.0471	1.000	1.000
237	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS1(3), DHRS2(3), DHRS3(2), DHRS7(6), DHRSX(2), ESCO1(16), ESCO2(8), NAT6(1), PNPLA3(7), SH3GLB1(7)	6018126	55	26	55	12	16	24	7	0	8	0	0.133	1.000	1.000
238	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(8), ACADM(9), ACADS(3), ACADVL(9), ACSL1(13), ACSL3(7), ACSL4(21), CPT1A(9), CPT2(4), EHHADH(10), HADHA(5), PECR(6), SCP2(10), SLC25A20(4)	6111523	118	36	114	30	28	42	26	0	22	0	0.107	1.000	1.000
239	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	15	AKT1(4), EGFR(12), IGF1R(13), MYC(8), POLR2A(21), PPP2CA(6), PRKCA(11), RB1(26), TEP1(13), TERF1(1), TERT(4), TNKS(15), TP53(74), XRCC5(8)	10199390	216	106	189	57	79	53	39	3	39	3	0.0284	1.000	1.000
240	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	CARM1(5), DHRS1(3), DHRS2(3), DHRS3(2), DHRS7(6), DHRSX(2), HEMK1(2), LCMT1(2), LCMT2(9), METTL2B(4), METTL6(4), PRMT2(1), PRMT3(8), PRMT5(10), PRMT6(5), PRMT7(5), PRMT8(7), WBSCR22(2)	5308040	80	32	79	24	21	34	8	1	16	0	0.239	1.000	1.000
241	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	64	ATM(54), CCNA1(5), CCNB1(8), CCND1(14), CCND2(9), CCND3(4), CCNE1(6), CCNE2(8), CCNG2(2), CCNH(7), CDC25A(8), CDK2(2), CDK4(2), CDK7(7), CDKN1A(1), CDKN1B(7), CDKN2A(1), CDKN2C(4), CDKN2D(1), CREB3L1(3), CREB3L3(7), CREB3L4(6), E2F1(9), E2F2(3), E2F3(4), E2F4(3), E2F5(5), E2F6(1), GBA2(9), MCM2(7), MCM3(9), MCM4(11), MCM5(8), MCM6(6), MCM7(6), MDM2(5), MYC(8), MYT1(18), NACA(20), PCNA(3), POLA2(3), POLE(47), POLE2(4), PRIM1(3), RB1(26), RBL1(13), RPA1(6), RPA2(3), RPA3(3), TFDP1(13), TFDP2(6), TNXB(19), TP53(74), WEE1(2)	27079694	523	146	475	124	144	185	99	3	85	7	0.00144	1.000	1.000
242	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CD4(6), CSF1(6), CSF2(1), CSF3(1), HLA-DRA(1), IFNA1(2), IFNB1(3), IFNG(10), IL10(4), IL11(2), IL12A(5), IL12B(2), IL15(2), IL2(2), IL3(2), IL4(1), IL5(2), IL6(5), IL7(1), LTA(3), PDGFA(3), TGFB1(1), TGFB2(5), TGFB3(9)	4650214	79	42	78	26	22	35	10	1	11	0	0.383	1.000	1.000
243	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT1(6), ACAT2(4), ACOT11(5), ACYP1(2), DHRS1(3), DHRS2(3), DHRS3(2), DHRS7(6), DHRSX(2), ECHS1(3), EHHADH(10), ESCO1(16), ESCO2(8), FN3K(5), GCDH(4), HADHA(5), NAT6(1), PNPLA3(7), SH3GLB1(7), YOD1(2)	9402046	101	41	101	27	25	42	19	0	15	0	0.219	1.000	1.000
244	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(6), ADCY3(12), ADCY9(27), AK1(1), ARF1(3), ARF3(4), ARF4(3), ARF5(4), ARF6(3), ARL4D(1), ATP6V0A1(8), ATP6V0A2(12), ATP6V0A4(11), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(2), ATP6V0D2(11), ATP6V1A(7), ATP6V1C1(4), ATP6V1C2(12), ATP6V1D(3), ATP6V1E1(6), ATP6V1E2(4), ATP6V1F(2), ATP6V1G1(2), ATP6V1G2(2), ATP6V1G3(2), ATP6V1H(7), ERO1L(6), GNAS(24), PDIA4(5), PLCG1(12), PLCG2(27), PRKCA(11), SEC61A1(5), SEC61A2(3), SEC61B(2), SEC61G(3), TRIM23(11)	13444408	271	65	264	62	92	88	47	2	38	4	0.00106	1.000	1.000
245	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA1(4), ANXA2(4), ANXA3(3), ANXA4(10), ANXA5(3), ANXA6(12), CYP11A1(9), EDN1(4), EDNRA(5), EDNRB(4), HPGD(6), HSD11B1(6), PLA2G4A(13), PRL(9), PTGDR(9), PTGDS(4), PTGER2(3), PTGER4(12), PTGFR(10), PTGIR(3), PTGIS(7), PTGS1(5), PTGS2(9), SCGB1A1(2), TBXAS1(7)	7412477	163	49	161	36	45	61	28	2	27	0	0.00484	1.000	1.000
246	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(3), ST3GAL1(2), ST3GAL2(6), ST3GAL4(3), ST3GAL5(4), ST6GALNAC2(4), ST6GALNAC4(4), ST8SIA1(2)	1942787	28	21	27	10	12	11	4	0	1	0	0.445	1.000	1.000
247	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	31	ADH1A(2), ADH1B(5), ADH4(4), ADH6(9), ADH7(4), ADHFE1(5), ALDH1A3(8), ALDH3A1(4), ALDH3B2(7), AOC2(7), AOC3(10), AOX1(18), COMT(3), DBH(9), DCT(11), DDC(8), FAH(6), GOT1(9), GOT2(3), GSTZ1(5), HGD(4), HPD(2), MAOA(12), MAOB(7), PNMT(2), TAT(7), TH(3), TPO(14), TYR(12)	11116639	200	56	196	54	62	65	44	2	27	0	0.0253	1.000	1.000
248	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	32	CD14(2), CHUK(8), ELK1(3), FOS(3), IKBKB(13), IKBKG(3), IRAK1(4), JUN(1), LY96(4), MAP2K3(7), MAP2K4(9), MAP2K6(10), MAP3K1(30), MAP3K7(9), MAPK14(4), MAPK8(11), MYD88(2), NFKB1(10), NFKBIA(3), PPARA(2), RELA(6), TIRAP(2), TLR10(19), TLR2(16), TLR3(10), TLR4(17), TLR6(14), TLR7(17), TLR9(6), TOLLIP(1), TRAF6(7)	13189970	253	65	250	57	54	99	52	0	45	3	0.00649	1.000	1.000
249	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	28	BRAF(10), CPEB1(9), EGFR(12), ERBB2(10), ERBB4(27), ETS1(6), ETS2(6), ETV6(6), ETV7(4), FMN2(27), GRB2(3), KRAS(52), MAP2K1(2), MAPK1(2), MAPK3(3), NOTCH1(10), NOTCH2(18), NOTCH3(29), NOTCH4(9), PIWIL1(21), PIWIL2(14), PIWIL3(10), PIWIL4(14), RAF1(9), SOS1(13), SOS2(17), SPIRE1(9), SPIRE2(4)	17642222	356	110	303	81	87	161	61	6	39	2	0.00118	1.000	1.000
250	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(21), COL4A2(14), COL4A3(25), COL4A4(23), COL4A5(26), COL4A6(31), F10(12), F11(15), F12(2), F2(8), F2R(6), F5(47), F8(45), F9(14), FGA(26), FGB(7), FGG(9), KLKB1(10), PROC(4), PROS1(21), SERPINC1(10), SERPING1(7)	16412302	383	70	365	94	84	177	65	2	49	6	0.0124	1.000	1.000
251	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(21), COL4A2(14), COL4A3(25), COL4A4(23), COL4A5(26), COL4A6(31), P4HB(5), SLC23A1(6), SLC23A2(7), SLC2A1(2), SLC2A3(8)	9449324	168	48	163	49	40	79	21	2	22	4	0.117	1.000	1.000
252	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(8), CTH(6), GOT1(9), GOT2(3), LDHA(6), LDHB(3), LDHC(5), MPST(1)	2443982	41	26	40	13	6	17	10	1	7	0	0.647	1.000	1.000
253	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	CREB1(5), GRB2(3), HRAS(1), PTK2B(15), SHC1(6), SOS1(13), SRC(3)	3131844	46	31	43	14	14	20	10	0	2	0	0.467	1.000	1.000
254	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(22), C5(18), C6(16), C7(20), ICAM1(2), IL6(5), ITGA4(10), ITGAL(17), ITGB1(8), ITGB2(15), SELP(13), SELPLG(9), VCAM1(12)	9034468	167	51	160	44	40	71	25	0	29	2	0.0372	1.000	1.000
255	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(5), ACAD9(8), ADH1A(2), ADH1B(5), ADH4(4), ADH6(9), ADH7(4), ADHFE1(5), DHRS1(3), DHRS2(3), DHRS3(2), DHRS7(6), DHRSX(2), ESCO1(16), ESCO2(8), NAT6(1), PNPLA3(7), SH3GLB1(7)	9147786	97	33	97	24	31	34	15	0	16	1	0.102	1.000	1.000
256	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(6), CSF1R(8), DDX20(4), E2F1(9), E2F4(3), ETS1(6), ETS2(6), ETV3(9), FOS(3), HDAC2(3), HDAC5(12), HRAS(1), JUN(1), NCOR2(24), RBL1(13), RBL2(19), SIN3A(29), SIN3B(13)	9425937	169	58	162	42	58	47	30	0	33	1	0.0246	1.000	1.000
257	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	12	ACTN1(9), ACTN2(16), BCAR1(8), CSK(1), CTNNA1(17), CTNNA2(16), CTNNB1(80), PTK2(12), PXN(6), SRC(3), VCL(11)	6836403	179	99	120	47	36	91	30	2	18	2	0.0621	1.000	1.000
258	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	CBL(12), EGF(19), EGFR(12), GRB2(3), HRAS(1), MAP2K1(2), MAPK1(2), MAPK3(3), PTPRB(28), RAF1(9), RASA1(29), SHC1(6), SOS1(13), SPRY1(3), SPRY2(5), SPRY3(6), SPRY4(2), SRC(3)	9178228	158	59	151	36	39	57	35	0	26	1	0.0483	1.000	1.000
259	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(11), IL13RA2(7), IL4R(6), JAK1(20), JAK2(17), TYK2(10)	3765029	71	32	71	23	14	24	18	1	11	3	0.573	1.000	1.000
260	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(11), IL13RA2(7), IL4R(6), JAK1(20), JAK2(17), TYK2(10)	3765029	71	32	71	23	14	24	18	1	11	3	0.573	1.000	1.000
261	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(19), CAPN1(5), CAPNS1(2), CAPNS2(3), CDK5(2), CDK5R1(3), CSNK1A1(3), CSNK1D(3), GSK3B(13), MAPT(9), PPP2CA(6)	3361556	68	29	67	22	31	19	9	0	9	0	0.317	1.000	1.000
262	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(17), EGF(19), EGFR(12), HGS(8), RAB5A(2), TF(13), TFRC(4)	4655220	75	27	73	25	20	28	15	0	12	0	0.570	1.000	1.000
263	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(52), MAP2(31), PPP1CA(2), PPP2CA(6), PRKACB(3), PRKACG(9), PRKAG1(3), PRKAR2A(4), PRKAR2B(3), PRKCE(10)	6652974	123	39	120	30	24	47	28	0	21	3	0.209	1.000	1.000
264	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	16	ALOX12(8), ALOX15(9), ALOX15B(6), ALOX5(10), ALOX5AP(3), DPEP1(3), GGT1(5), LTA4H(4), PLA2G6(9), PTGDS(4), PTGES(2), PTGIS(7), PTGS1(5), PTGS2(9), TBXAS1(7)	5401004	91	33	89	27	39	27	16	1	8	0	0.149	1.000	1.000
265	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(1), DCXR(1), GUSB(5), RPE(5), UGDH(2), UGP2(6), UGT1A1(11), UGT1A10(7), UGT1A3(2), UGT1A4(3), UGT1A5(7), UGT1A6(5), UGT1A7(7), UGT1A9(3), UGT2A1(9), UGT2A3(5), UGT2B10(18), UGT2B11(8), UGT2B15(9), UGT2B17(7), UGT2B28(15), UGT2B4(11), UGT2B7(5), XYLB(5)	9582049	157	37	149	32	31	73	29	1	23	0	0.0133	1.000	1.000
266	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	8	CAMK1(3), CAMK1G(5), HDAC9(15), MEF2A(3), MEF2B(1), MEF2C(10), MEF2D(7), YWHAH(3)	2977293	47	18	46	16	16	13	10	0	7	1	0.486	1.000	1.000
267	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(8), IFNA1(2), IFNB1(3), IKBKB(13), IL1B(2), IL1R1(5), IL1RAP(8), IL6(5), IRAK1(4), IRAK2(9), IRAK3(10), JUN(1), MAP2K3(7), MAP2K6(10), MAP3K1(30), MAP3K7(9), MAPK14(4), MAPK8(11), MYD88(2), NFKB1(10), NFKBIA(3), RELA(6), TGFB1(1), TGFB2(5), TGFB3(9), TOLLIP(1), TRAF6(7)	10714977	185	54	181	41	39	75	35	0	35	1	0.0312	1.000	1.000
268	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	38	AKT1(4), ATF2(8), CDC42(3), DLD(5), DUSP10(5), DUSP8(1), GAB1(7), GCK(2), IL1R1(5), JUN(1), MAP2K4(9), MAP2K5(3), MAP2K7(4), MAP3K1(30), MAP3K10(7), MAP3K11(5), MAP3K12(6), MAP3K13(13), MAP3K2(12), MAP3K3(8), MAP3K4(21), MAP3K5(25), MAP3K7(9), MAP3K9(6), MAPK10(10), MAPK7(14), MAPK8(11), MAPK9(4), MYEF2(7), NFATC3(11), NR2C2(7), PAPPA(27), SHC1(6), TP53(74), TRAF6(7), ZAK(14)	17971185	391	123	363	95	124	130	65	4	66	2	0.0160	1.000	1.000
269	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	36	ANKHD1(27), EEF1A2(4), EEF1B2(3), EEF1D(6), EEF1G(5), EEF2(13), EEF2K(11), EIF1AX(4), EIF2AK1(8), EIF2AK2(13), EIF2AK3(12), EIF2B2(5), EIF2B3(7), EIF2B4(4), EIF2B5(5), EIF2S1(2), EIF2S2(9), EIF2S3(6), EIF4A1(5), EIF4A2(8), EIF4E(1), EIF4EBP2(1), EIF4G1(16), EIF4G3(23), EIF5(3), EIF5A(4), EIF5B(15), ETF1(7), GSPT2(18), PABPC1(10), PABPC3(8), PAIP1(7), SLC35A4(5)	15890643	275	71	268	57	81	99	44	6	42	3	0.000814	1.000	1.000
270	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	192	ACTB(3), ACTG1(6), ACTN1(9), ACTN2(16), ACTN4(8), AKT1(4), AKT2(6), AKT3(11), ARHGAP5(21), BAD(1), BCAR1(8), BIRC2(10), BIRC3(5), BRAF(10), CAPN2(11), CAV1(2), CAV2(1), CCND1(14), CCND2(9), CCND3(4), CDC42(3), CHAD(3), COL11A1(35), COL11A2(10), COL1A1(12), COL1A2(24), COL2A1(16), COL3A1(18), COL4A1(21), COL4A2(14), COL4A4(23), COL4A6(31), COL5A1(30), COL5A2(21), COL5A3(19), COL6A1(5), COL6A2(12), COL6A3(44), COL6A6(27), COMP(7), CRK(2), CRKL(6), CTNNB1(80), DIAPH1(12), DOCK1(21), EGF(19), EGFR(12), ELK1(3), ERBB2(10), FARP2(14), FIGF(5), FLNA(38), FLNB(33), FLNC(37), FLT1(20), FN1(42), FYN(5), GRB2(3), GSK3B(13), HGF(14), HRAS(1), IBSP(7), IGF1(5), IGF1R(13), ILK(5), ITGA1(17), ITGA10(9), ITGA11(7), ITGA2(19), ITGA2B(11), ITGA3(4), ITGA4(10), ITGA5(10), ITGA6(12), ITGA7(14), ITGA8(19), ITGA9(16), ITGAV(10), ITGB1(8), ITGB3(11), ITGB4(8), ITGB5(8), ITGB6(7), ITGB7(4), ITGB8(9), JUN(1), KDR(26), LAMA1(31), LAMA2(61), LAMA3(29), LAMA4(16), LAMA5(17), LAMB1(23), LAMB2(26), LAMB3(15), LAMB4(30), LAMC1(18), LAMC2(17), LAMC3(17), MAP2K1(2), MAPK1(2), MAPK10(10), MAPK3(3), MAPK8(11), MAPK9(4), MET(17), MYL2(2), MYL5(1), MYL7(1), MYL9(3), MYLK(14), MYLK2(8), PAK1(3), PAK2(3), PAK3(16), PAK6(4), PAK7(9), PARVA(4), PARVB(4), PARVG(7), PDGFA(3), PDGFB(2), PDGFC(3), PDGFD(8), PDGFRA(24), PDGFRB(12), PDPK1(3), PGF(3), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(99), PIK3R2(7), PIK3R3(9), PIK3R5(10), PIP5K1C(6), PPP1CA(2), PPP1CB(9), PPP1CC(2), PPP1R12A(8), PRKCA(11), PRKCG(8), PTEN(227), PTK2(12), PXN(6), RAC1(1), RAC2(2), RAF1(9), RAP1A(4), RAP1B(2), RAPGEF1(10), RELN(48), RHOA(3), ROCK1(22), ROCK2(17), SHC1(6), SHC2(5), SHC3(15), SHC4(5), SOS1(13), SOS2(17), SPP1(2), SRC(3), THBS1(10), THBS2(20), THBS3(3), THBS4(12), TLN1(23), TLN2(29), TNC(26), TNN(19), TNR(14), TNXB(19), VASP(3), VAV1(12), VAV2(7), VAV3(13), VCL(11), VEGFA(2), VEGFB(3), VEGFC(6), VTN(3), VWF(25), ZYX(11)	132352116	2775	237	2453	741	705	958	487	58	499	68	3.19e-08	1.000	1.000
271	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	199	ABI2(4), ACTN1(9), ACTN2(16), ACTN4(8), APC(56), ARAF(12), ARHGEF1(12), ARHGEF12(28), ARHGEF4(8), ARHGEF6(25), ARHGEF7(15), ARPC1A(6), ARPC1B(5), ARPC2(1), ARPC3(1), ARPC4(1), ARPC5(1), BAIAP2(5), BCAR1(8), BDKRB1(3), BDKRB2(8), BRAF(10), CD14(2), CDC42(3), CFL1(1), CFL2(8), CHRM1(6), CHRM2(10), CHRM3(8), CHRM4(9), CHRM5(9), CRK(2), CRKL(6), CSK(1), CYFIP1(8), CYFIP2(18), DIAPH1(12), DIAPH2(31), DIAPH3(25), DOCK1(21), EGF(19), EGFR(12), EZR(4), F2(8), F2R(6), FGD1(15), FGD3(9), FGF10(2), FGF11(1), FGF12(5), FGF13(4), FGF14(4), FGF16(1), FGF17(1), FGF18(1), FGF21(1), FGF23(3), FGF3(1), FGF5(9), FGF6(3), FGF7(5), FGF8(3), FGF9(1), FGFR1(9), FGFR2(33), FGFR3(3), FGFR4(11), FN1(42), GIT1(9), GNA12(7), GNA13(7), GNG12(1), GSN(4), HRAS(1), INS(1), IQGAP1(12), IQGAP2(24), IQGAP3(16), ITGA1(17), ITGA10(9), ITGA11(7), ITGA2(19), ITGA2B(11), ITGA3(4), ITGA4(10), ITGA5(10), ITGA6(12), ITGA7(14), ITGA8(19), ITGA9(16), ITGAD(11), ITGAE(9), ITGAL(17), ITGAM(21), ITGAV(10), ITGAX(14), ITGB1(8), ITGB2(15), ITGB3(11), ITGB4(8), ITGB5(8), ITGB6(7), ITGB7(4), ITGB8(9), KRAS(52), LIMK1(8), LIMK2(13), MAP2K1(2), MAP2K2(5), MAPK1(2), MAPK3(3), MOS(6), MRAS(2), MSN(18), MYH10(29), MYH14(21), MYH9(23), MYL2(2), MYL5(1), MYL7(1), MYL9(3), MYLK(14), MYLK2(8), NCKAP1(8), NCKAP1L(19), NRAS(9), PAK1(3), PAK2(3), PAK3(16), PAK6(4), PAK7(9), PDGFA(3), PDGFB(2), PDGFRA(24), PDGFRB(12), PFN1(1), PFN2(2), PFN4(2), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(99), PIK3R2(7), PIK3R3(9), PIK3R5(10), PIP4K2A(5), PIP4K2B(7), PIP4K2C(3), PIP5K1A(8), PIP5K1B(5), PIP5K1C(6), PPP1CA(2), PPP1CB(9), PPP1CC(2), PPP1R12A(8), PPP1R12B(19), PTK2(12), PXN(6), RAC1(1), RAC2(2), RAF1(9), RDX(17), RHOA(3), ROCK1(22), ROCK2(17), RRAS(3), RRAS2(4), SCIN(6), SLC9A1(7), SOS1(13), SOS2(17), SSH1(15), SSH2(13), SSH3(4), TIAM1(27), TIAM2(14), VAV1(12), VAV2(7), VAV3(13), VCL(11), WAS(11), WASF1(3), WASF2(3), WASL(8)	100375796	2053	224	1825	575	542	726	389	25	336	35	0.000136	1.000	1.000
272	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	107	ACTN1(9), ACTN2(16), ACTN4(8), ARHGAP5(21), BCAR1(8), CDC42(3), CDH5(6), CLDN1(3), CLDN10(7), CLDN11(2), CLDN15(5), CLDN16(4), CLDN17(4), CLDN18(7), CLDN19(2), CLDN2(3), CLDN20(3), CLDN22(2), CLDN8(4), CLDN9(3), CTNNA1(17), CTNNA2(16), CTNNA3(13), CTNNB1(80), CTNND1(27), CXCL12(3), CXCR4(1), CYBA(2), CYBB(9), ESAM(1), EZR(4), F11R(1), GNAI1(5), GNAI2(6), GNAI3(4), ICAM1(2), ITGA4(10), ITGAL(17), ITGAM(21), ITGB1(8), ITGB2(15), ITK(7), JAM2(9), JAM3(2), MAPK11(3), MAPK12(2), MAPK13(4), MAPK14(4), MLLT4(21), MMP2(7), MMP9(12), MSN(18), MYL2(2), MYL5(1), MYL7(1), MYL9(3), NCF1(2), NCF2(8), NCF4(5), NOX1(16), NOX3(7), OCLN(2), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(99), PIK3R2(7), PIK3R3(9), PIK3R5(10), PLCG1(12), PLCG2(27), PRKCA(11), PRKCG(8), PTK2(12), PTK2B(15), PTPN11(8), PXN(6), RAC1(1), RAC2(2), RAP1A(4), RAP1B(2), RAPGEF3(8), RAPGEF4(15), RASSF5(3), RHOA(3), RHOH(1), ROCK1(22), ROCK2(17), SIPA1(1), THY1(1), TXK(6), VASP(3), VAV1(12), VAV2(7), VAV3(13), VCAM1(12), VCL(11)	44542115	1110	221	922	278	269	387	228	12	193	21	0.000244	1.000	1.000
273	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	128	ACACA(31), ACACB(29), AKT1(4), AKT2(6), AKT3(11), ARAF(12), BAD(1), BRAF(10), CALM1(2), CALM2(3), CALML3(3), CALML6(4), CBL(12), CBLB(12), CBLC(5), CRK(2), CRKL(6), ELK1(3), EXOC7(4), FASN(9), FBP1(2), FBP2(1), FLOT1(1), FLOT2(2), FOXO1(12), G6PC(5), G6PC2(11), GCK(2), GRB2(3), GSK3B(13), GYS1(13), GYS2(16), HRAS(1), IKBKB(13), INPP5D(9), INS(1), INSR(18), IRS1(13), IRS4(20), KRAS(52), LIPE(13), MAP2K1(2), MAP2K2(5), MAPK1(2), MAPK10(10), MAPK3(3), MAPK8(11), MAPK9(4), MKNK1(3), MKNK2(2), NRAS(9), PCK1(9), PCK2(7), PDE3A(19), PDE3B(15), PDPK1(3), PFKL(8), PFKM(8), PFKP(8), PHKA1(20), PHKA2(21), PHKB(13), PHKG1(7), PHKG2(3), PIK3CA(172), PIK3CB(17), PIK3CD(12), PIK3CG(23), PIK3R1(99), PIK3R2(7), PIK3R3(9), PIK3R5(10), PKLR(6), PPARGC1A(9), PPP1CA(2), PPP1CB(9), PPP1CC(2), PPP1R3A(32), PPP1R3B(2), PPP1R3C(4), PRKAA1(8), PRKAA2(11), PRKAB1(6), PRKAB2(1), PRKACA(6), PRKACB(3), PRKACG(9), PRKAG1(3), PRKAG2(4), PRKAG3(6), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PRKCI(6), PRKCZ(2), PRKX(2), PTPN1(5), PTPRF(26), PYGB(11), PYGL(8), PYGM(10), RAF1(9), RAPGEF1(10), RHEB(3), RHOQ(1), RPS6(7), RPS6KB1(3), RPS6KB2(4), SH2B2(1), SHC1(6), SHC2(5), SHC3(15), SHC4(5), SLC2A4(9), SOCS2(6), SOCS4(5), SORBS1(18), SOS1(13), SOS2(17), SREBF1(2), TRIP10(10), TSC1(12), TSC2(14)	56199251	1314	221	1121	331	370	428	260	14	222	20	3.25e-06	1.000	1.000
274	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	142	APC(56), AXIN1(9), AXIN2(9), BTRC(14), CACYBP(2), CAMK2A(9), CAMK2B(4), CAMK2D(5), CAMK2G(5), CCND1(14), CCND2(9), CCND3(4), CER1(4), CHD8(34), CREBBP(32), CSNK1A1(3), CSNK1A1L(4), CSNK1E(3), CSNK2A1(9), CSNK2A2(4), CTBP1(1), CTBP2(3), CTNNB1(80), CUL1(13), CXXC4(1), DAAM1(18), DAAM2(10), DKK1(3), DKK2(3), DKK4(3), DVL1(3), DVL2(10), DVL3(9), EP300(32), FBXW11(5), FOSL1(3), FZD1(3), FZD10(9), FZD2(8), FZD3(9), FZD4(4), FZD5(2), FZD6(13), FZD7(4), FZD8(2), FZD9(6), GSK3B(13), JUN(1), LEF1(8), LRP5(14), LRP6(26), MAP3K7(9), MAPK10(10), MAPK8(11), MAPK9(4), MYC(8), NFAT5(16), NFATC1(10), NFATC2(13), NFATC3(11), NFATC4(5), NKD1(3), NLK(5), PLCB1(5), PLCB2(8), PLCB3(11), PLCB4(19), PORCN(9), PPARD(3), PPP2CA(6), PPP2CB(4), PPP2R1A(31), PPP2R1B(5), PPP2R2A(10), PPP2R2B(12), PPP2R2C(2), PPP3CA(4), PPP3CB(6), PPP3CC(6), PPP3R1(1), PRICKLE1(6), PRICKLE2(3), PRKACA(6), PRKACB(3), PRKACG(9), PRKCA(11), PRKCG(8), PRKX(2), PSEN1(5), RAC1(1), RAC2(2), RBX1(1), RHOA(3), ROCK1(22), ROCK2(17), RUVBL1(2), SENP2(11), SFRP1(6), SFRP2(4), SFRP4(9), SFRP5(2), SIAH1(6), SMAD2(9), SMAD3(7), SMAD4(5), SOX17(7), TBL1X(8), TBL1XR1(16), TCF7(3), TCF7L1(4), TCF7L2(11), TP53(74), VANGL1(6), VANGL2(10), WIF1(5), WNT1(1), WNT10A(2), WNT10B(1), WNT11(5), WNT16(7), WNT2(3), WNT2B(6), WNT3(3), WNT3A(1), WNT4(1), WNT5A(6), WNT5B(3), WNT6(1), WNT7A(3), WNT7B(2), WNT8A(2), WNT8B(5), WNT9A(4), WNT9B(2)	56493350	1161	217	1041	307	370	404	213	10	157	7	1.39e-05	1.000	1.000
275	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	129	ACTB(3), ACTG1(6), ACTN1(9), ACTN2(16), ACTN4(8), AKT1(4), AKT2(6), AKT3(11), AMOTL1(12), ASH1L(42), CASK(17), CDC42(3), CDK4(2), CGN(14), CLDN1(3), CLDN10(7), CLDN11(2), CLDN15(5), CLDN16(4), CLDN17(4), CLDN18(7), CLDN19(2), CLDN2(3), CLDN20(3), CLDN22(2), CLDN8(4), CLDN9(3), CSNK2A1(9), CSNK2A2(4), CTNNA1(17), CTNNA2(16), CTNNA3(13), CTNNB1(80), CTTN(3), EPB41(11), EPB41L1(15), EPB41L2(14), EPB41L3(17), EXOC3(8), EXOC4(6), F11R(1), GNAI1(5), GNAI2(6), GNAI3(4), HCLS1(11), HRAS(1), IGSF5(5), INADL(21), JAM2(9), JAM3(2), KRAS(52), LLGL1(10), LLGL2(6), MAGI1(22), MAGI2(28), MAGI3(16), MLLT4(21), MPDZ(21), MPP5(10), MRAS(2), MYH1(43), MYH10(29), MYH11(30), MYH13(22), MYH14(21), MYH15(23), MYH2(41), MYH3(31), MYH4(30), MYH6(16), MYH7(35), MYH7B(14), MYH8(29), MYH9(23), MYL2(2), MYL5(1), MYL7(1), MYL9(3), NRAS(9), OCLN(2), PARD3(19), PARD6B(3), PARD6G(1), PPM1J(3), PPP2CA(6), PPP2CB(4), PPP2R1A(31), PPP2R1B(5), PPP2R2A(10), PPP2R2B(12), PPP2R2C(2), PPP2R3A(10), PPP2R3B(9), PPP2R4(3), PRKCA(11), PRKCD(5), PRKCE(10), PRKCG(8), PRKCH(10), PRKCI(6), PRKCQ(9), PRKCZ(2), PTEN(227), RAB13(3), RAB3B(2), RHOA(3), RRAS(3), RRAS2(4), SPTAN1(31), SRC(3), SYMPK(16), TJAP1(6), TJP1(24), TJP2(16), TJP3(6), VAPA(5), YES1(8), ZAK(14)	70594305	1623	216	1382	443	420	555	266	53	285	44	0.00137	1.000	1.000
276	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	246	ACVR1B(8), ACVR1C(6), AKT1(4), AKT2(6), AKT3(11), ARRB1(4), ARRB2(5), ATF2(8), ATF4(3), BDNF(7), BRAF(10), CACNA1A(19), CACNA1B(31), CACNA1C(38), CACNA1D(28), CACNA1E(58), CACNA1F(38), CACNA1G(23), CACNA1H(12), CACNA1I(8), CACNA1S(34), CACNA2D1(15), CACNA2D2(11), CACNA2D3(22), CACNA2D4(16), CACNB1(11), CACNB2(13), CACNB3(5), CACNB4(13), CACNG1(1), CACNG2(4), CACNG3(10), CACNG4(6), CACNG5(3), CACNG6(4), CACNG7(7), CACNG8(1), CASP3(4), CD14(2), CDC25B(3), CDC42(3), CHUK(8), CRK(2), CRKL(6), DAXX(9), DDIT3(2), DUSP1(2), DUSP10(5), DUSP14(4), DUSP16(11), DUSP3(2), DUSP5(4), DUSP6(2), DUSP7(3), DUSP8(1), DUSP9(1), ECSIT(5), EGF(19), EGFR(12), ELK1(3), ELK4(3), FAS(8), FASLG(7), FGF10(2), FGF11(1), FGF12(5), FGF13(4), FGF14(4), FGF16(1), FGF17(1), FGF18(1), FGF21(1), FGF23(3), FGF3(1), FGF5(9), FGF6(3), FGF7(5), FGF8(3), FGF9(1), FGFR1(9), FGFR2(33), FGFR3(3), FGFR4(11), FLNA(38), FLNB(33), FLNC(37), FOS(3), GADD45G(1), GNA12(7), GNG12(1), GRB2(3), HRAS(1), IKBKB(13), IKBKG(3), IL1B(2), IL1R1(5), IL1R2(5), JUN(1), KRAS(52), MAP2K1(2), MAP2K2(5), MAP2K3(7), MAP2K4(9), MAP2K5(3), MAP2K6(10), MAP2K7(4), MAP3K1(30), MAP3K10(7), MAP3K12(6), MAP3K13(13), MAP3K2(12), MAP3K3(8), MAP3K4(21), MAP3K5(25), MAP3K6(7), MAP3K7(9), MAP3K8(10), MAP4K1(12), MAP4K2(5), MAP4K3(16), MAP4K4(10), MAPK1(2), MAPK10(10), MAPK11(3), MAPK12(2), MAPK13(4), MAPK14(4), MAPK3(3), MAPK7(14), MAPK8(11), MAPK8IP1(4), MAPK8IP2(1), MAPK8IP3(9), MAPK9(4), MAPKAPK2(5), MAPKAPK3(5), MAPKAPK5(5), MAPT(9), MAX(9), MEF2C(10), MKNK1(3), MKNK2(2), MOS(6), MRAS(2), MYC(8), NF1(35), NFATC2(13), NFATC4(5), NFKB1(10), NFKB2(9), NLK(5), NR4A1(6), NRAS(9), NTF3(5), NTRK1(13), NTRK2(13), PAK1(3), PAK2(3), PDGFA(3), PDGFB(2), PDGFRA(24), PDGFRB(12), PLA2G12A(1), PLA2G12B(4), PLA2G2D(2), PLA2G2E(5), PLA2G2F(3), PLA2G3(7), PLA2G4A(13), PLA2G5(1), PLA2G6(9), PPM1A(5), PPM1B(3), PPP3CA(4), PPP3CB(6), PPP3CC(6), PPP3R1(1), PPP5C(7), PRKACA(6), PRKACB(3), PRKACG(9), PRKCA(11), PRKCG(8), PRKX(2), PTPN5(8), PTPN7(6), PTPRR(17), RAC1(1), RAC2(2), RAF1(9), RAP1A(4), RAP1B(2), RAPGEF2(31), RASA1(29), RASA2(11), RASGRF1(11), RASGRF2(18), RASGRP1(8), RASGRP2(4), RASGRP3(11), RASGRP4(6), RPS6KA1(1), RPS6KA2(13), RPS6KA3(19), RPS6KA4(2), RPS6KA5(11), RPS6KA6(19), RRAS(3), RRAS2(4), SOS1(13), SOS2(17), SRF(3), STK3(12), STK4(9), STMN1(4), TAOK1(12), TAOK2(8), TAOK3(5), TGFB1(1), TGFB2(5), TGFB3(9), TGFBR1(6), TGFBR2(6), TNFRSF1A(4), TP53(74), TRAF2(3), TRAF6(7), ZAK(14)	104048776	2054	201	1923	623	633	723	350	28	303	17	0.000141	1.000	1.000
277	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	82	ACVR1(8), ACVR1B(8), ACVRL1(2), AKT1(4), AURKB(4), BMPR1A(5), BMPR2(12), BUB1(10), CDKL1(4), CDKL2(5), CDS1(5), CLK1(7), CLK2(8), CLK4(7), COL4A3BP(3), CSNK2A1(9), CSNK2A2(4), DGKA(9), DGKB(23), DGKD(18), DGKE(5), DGKG(11), DGKH(10), DGKQ(2), DGKZ(10), IMPA1(3), INPP1(3), INPP4A(19), INPP4B(16), INPP5A(4), INPPL1(18), ITPKA(1), ITPKB(11), MAP3K10(7), MOS(6), NEK1(19), NEK3(7), OCRL(19), PIK3C2A(22), PIK3C2B(10), PIK3C2G(16), PIK3CA(172), PIK3CB(17), PIK3CG(23), PIM2(5), PLCB1(5), PLCB2(8), PLCB3(11), PLCB4(19), PLCD1(4), PLCG1(12), PLCG2(27), PLK3(8), PRKACA(6), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PRKCA(11), PRKCD(5), PRKCE(10), PRKCG(8), PRKCH(10), PRKCQ(9), PRKCZ(2), PRKD1(8), PRKG1(11), RAF1(9), RPS6KA1(1), RPS6KA2(13), RPS6KA3(19), RPS6KA4(2), RPS6KB1(3), STK11(2), TGFBR1(6), VRK1(12)	41274078	859	185	743	253	243	278	204	10	120	4	0.0972	1.000	1.000
278	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	99	ADCY1(21), ADCY2(19), ADCY3(12), ADCY4(12), ADCY5(15), ADCY6(14), ADCY7(9), ADCY8(22), ADCY9(27), CALM1(2), CALM2(3), CALML3(3), CALML6(4), CAMK2A(9), CAMK2B(4), CAMK2D(5), CAMK2G(5), CREB1(5), CREB3L1(3), CREB3L2(4), CREB3L3(7), CREB3L4(6), CREBBP(32), CTNNB1(80), DCT(11), DVL1(3), DVL2(10), DVL3(9), EDN1(4), EDNRB(4), EP300(32), FZD1(3), FZD10(9), FZD2(8), FZD3(9), FZD4(4), FZD5(2), FZD6(13), FZD7(4), FZD8(2), FZD9(6), GNAI1(5), GNAI2(6), GNAI3(4), GNAO1(6), GNAQ(3), GNAS(24), GSK3B(13), HRAS(1), KIT(23), KITLG(3), KRAS(52), LEF1(8), MAP2K1(2), MAP2K2(5), MAPK1(2), MAPK3(3), MC1R(3), MITF(5), NRAS(9), PLCB1(5), PLCB2(8), PLCB3(11), PLCB4(19), POMC(4), PRKACA(6), PRKACB(3), PRKACG(9), PRKCA(11), PRKCG(8), PRKX(2), RAF1(9), TCF7(3), TCF7L1(4), TCF7L2(11), TYR(12), TYRP1(7), WNT1(1), WNT10A(2), WNT10B(1), WNT11(5), WNT16(7), WNT2(3), WNT2B(6), WNT3(3), WNT3A(1), WNT4(1), WNT5A(6), WNT5B(3), WNT6(1), WNT7A(3), WNT7B(2), WNT8A(2), WNT8B(5), WNT9A(4), WNT9B(2)	37866316	823	177	706	261	264	297	156	11	93	2	0.0131	1.000	1.000
279	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	108	ABL1(8), ANAPC1(21), ANAPC10(2), ANAPC2(6), ANAPC4(5), ANAPC5(8), ANAPC7(5), ATM(54), ATR(38), BUB1(10), BUB1B(6), BUB3(4), CCNA1(5), CCNA2(7), CCNB1(8), CCNB2(5), CCNB3(33), CCND1(14), CCND2(9), CCND3(4), CCNE1(6), CCNE2(8), CCNH(7), CDC14A(6), CDC14B(6), CDC16(11), CDC20(4), CDC23(5), CDC25A(8), CDC25B(3), CDC25C(5), CDC6(3), CDC7(11), CDK2(2), CDK4(2), CDK6(3), CDK7(7), CDKN1A(1), CDKN1B(7), CDKN2A(1), CDKN2C(4), CDKN2D(1), CHEK1(2), CHEK2(13), CREBBP(32), CUL1(13), DBF4(11), E2F1(9), E2F2(3), E2F3(4), EP300(32), ESPL1(12), FZR1(2), GADD45G(1), GSK3B(13), HDAC1(5), HDAC2(3), MAD1L1(12), MAD2L1(3), MAD2L2(2), MCM2(7), MCM3(9), MCM4(11), MCM5(8), MCM6(6), MCM7(6), MDM2(5), PCNA(3), PKMYT1(2), PLK1(4), PRKDC(54), PTTG1(2), RB1(26), RBL1(13), RBL2(19), RBX1(1), SKP2(6), SMAD2(9), SMAD3(7), SMAD4(5), SMC1A(18), SMC1B(19), TFDP1(13), TGFB1(1), TGFB2(5), TGFB3(9), TP53(74), WEE1(2), YWHAE(5), YWHAG(3), YWHAH(3), YWHAQ(1), YWHAZ(1)	49263559	892	172	845	221	250	291	175	5	158	13	0.00377	1.000	1.000
280	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	168	ADCY1(21), ADCY2(19), ADCY3(12), ADCY4(12), ADCY7(9), ADCY8(22), ADCY9(27), ADORA2A(6), ADORA2B(1), ADRA1A(12), ADRA1B(6), ADRA1D(1), ADRB2(7), ADRB3(3), AGTR1(4), ATP2A1(13), ATP2A2(8), ATP2A3(11), ATP2B1(15), ATP2B2(12), ATP2B3(16), ATP2B4(14), AVPR1A(7), AVPR1B(3), BDKRB1(3), BDKRB2(8), BST1(1), CACNA1A(19), CACNA1B(31), CACNA1C(38), CACNA1D(28), CACNA1E(58), CACNA1F(38), CACNA1G(23), CACNA1H(12), CACNA1I(8), CACNA1S(34), CALM1(2), CALM2(3), CALML3(3), CALML6(4), CAMK2A(9), CAMK2B(4), CAMK2D(5), CAMK2G(5), CAMK4(5), CCKAR(9), CCKBR(3), CD38(6), CHRM1(6), CHRM2(10), CHRM3(8), CHRM5(9), CHRNA7(5), CYSLTR1(8), CYSLTR2(5), DRD1(6), EDNRA(5), EDNRB(4), EGFR(12), ERBB2(10), ERBB3(19), ERBB4(27), F2R(6), GNA11(2), GNA14(7), GNA15(1), GNAL(6), GNAQ(3), GNAS(24), GRIN1(4), GRIN2A(25), GRIN2C(6), GRIN2D(5), GRM1(26), GRM5(26), GRPR(4), HRH1(10), HRH2(4), HTR2A(11), HTR2B(2), HTR2C(16), HTR4(6), HTR5A(12), HTR6(4), HTR7(5), ITPKA(1), ITPKB(11), ITPR1(34), ITPR2(35), ITPR3(22), LHCGR(17), LTB4R2(4), MYLK(14), MYLK2(8), NOS1(18), NOS3(11), NTSR1(5), OXTR(4), P2RX1(5), P2RX2(3), P2RX3(8), P2RX4(1), P2RX5(5), P2RX7(1), PDE1A(14), PDE1B(7), PDE1C(11), PDGFRA(24), PDGFRB(12), PHKA1(20), PHKA2(21), PHKB(13), PHKG1(7), PHKG2(3), PLCB1(5), PLCB2(8), PLCB3(11), PLCB4(19), PLCD1(4), PLCD3(3), PLCD4(10), PLCE1(39), PLCG1(12), PLCG2(27), PLCZ1(13), PLN(2), PPID(2), PPP3CA(4), PPP3CB(6), PPP3CC(6), PPP3R1(1), PRKACA(6), PRKACB(3), PRKACG(9), PRKCA(11), PRKCG(8), PRKX(2), PTAFR(4), PTGER3(4), PTGFR(10), PTK2B(15), RYR1(73), RYR2(109), RYR3(93), SLC25A4(2), SLC25A5(2), SLC25A6(5), SLC8A1(13), SLC8A2(6), SLC8A3(13), SPHK1(2), SPHK2(2), TACR1(7), TACR2(3), TACR3(9), TNNC1(2), TNNC2(3), TRHR(3), TRPC1(13), VDAC1(2), VDAC2(3), VDAC3(2)	98590383	1919	171	1872	743	653	690	332	15	212	17	0.638	1.000	1.000
281	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	126	ABL1(8), ABLIM1(6), ABLIM2(7), ABLIM3(8), ARHGEF12(28), CDC42(3), CDK5(2), CFL1(1), CFL2(8), CXCL12(3), CXCR4(1), DCC(34), DPYSL2(12), DPYSL5(4), EFNA1(1), EFNA3(1), EFNA4(3), EFNA5(3), EFNB1(6), EFNB2(2), EFNB3(1), EPHA1(11), EPHA2(5), EPHA3(18), EPHA4(19), EPHA5(25), EPHA6(20), EPHA7(10), EPHA8(13), EPHB1(26), EPHB2(11), EPHB3(6), EPHB4(4), EPHB6(11), FES(15), FYN(5), GNAI1(5), GNAI2(6), GNAI3(4), GSK3B(13), HRAS(1), ITGB1(8), KRAS(52), L1CAM(20), LIMK1(8), LIMK2(13), LRRC4C(13), MAPK1(2), MAPK3(3), MET(17), NCK1(4), NCK2(8), NFAT5(16), NFATC1(10), NFATC2(13), NFATC3(11), NFATC4(5), NGEF(15), NRAS(9), NRP1(13), NTN1(3), NTN4(5), NTNG1(7), PAK1(3), PAK2(3), PAK3(16), PAK6(4), PAK7(9), PLXNA1(24), PLXNA2(25), PLXNA3(18), PLXNB1(13), PLXNB2(16), PLXNB3(21), PLXNC1(26), PPP3CA(4), PPP3CB(6), PPP3CC(6), PPP3R1(1), PTK2(12), RAC1(1), RAC2(2), RASA1(29), RGS3(8), RHOA(3), RHOD(1), RND1(6), ROBO1(23), ROBO2(25), ROBO3(16), ROCK1(22), ROCK2(17), SEMA3A(8), SEMA3C(11), SEMA3D(12), SEMA3E(9), SEMA3F(6), SEMA3G(5), SEMA4A(8), SEMA4B(3), SEMA4C(7), SEMA4D(6), SEMA4F(11), SEMA4G(4), SEMA5A(19), SEMA5B(8), SEMA6A(9), SEMA6B(3), SEMA6C(5), SEMA6D(26), SEMA7A(11), SLIT1(13), SLIT2(28), SLIT3(19), SRGAP1(18), SRGAP2(14), SRGAP3(10), UNC5A(9), UNC5B(8), UNC5C(10), UNC5D(16)	69179806	1301	163	1223	432	405	469	224	9	183	11	0.100	1.000	1.000
282	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	233	ADCYAP1R1(5), ADORA1(3), ADORA2A(6), ADORA2B(1), ADORA3(4), ADRA1A(12), ADRA1B(6), ADRA2A(6), ADRA2B(5), ADRA2C(2), ADRB2(7), ADRB3(3), AGTR1(4), AGTR2(11), AVPR1A(7), AVPR1B(3), AVPR2(4), BDKRB1(3), BDKRB2(8), BRS3(17), C3AR1(9), C5AR1(4), CALCR(9), CALCRL(8), CCKAR(9), CCKBR(3), CGA(1), CHRM1(6), CHRM2(10), CHRM3(8), CHRM4(9), CHRM5(9), CNR1(11), CNR2(6), CRHR1(3), CRHR2(2), CTSG(3), CYSLTR1(8), CYSLTR2(5), DRD1(6), DRD2(8), DRD3(6), DRD5(11), EDNRA(5), EDNRB(4), F2(8), F2R(6), F2RL1(4), F2RL2(2), FPR1(2), FSHR(15), GABBR1(11), GABBR2(15), GABRA1(14), GABRA2(13), GABRA3(14), GABRA4(19), GABRA5(10), GABRA6(8), GABRB1(9), GABRB2(15), GABRB3(10), GABRD(6), GABRE(7), GABRG1(10), GABRG2(16), GABRG3(9), GABRP(5), GABRQ(11), GABRR1(3), GALR1(3), GALR3(2), GH1(2), GH2(1), GHR(8), GHRHR(2), GHSR(8), GIPR(5), GLP1R(5), GLP2R(11), GLRA1(8), GLRA2(8), GLRA3(9), GLRB(7), GNRHR(4), GPR156(7), GPR35(3), GPR50(8), GPR63(5), GPR83(3), GRIA1(12), GRIA2(21), GRIA3(21), GRIA4(17), GRID1(12), GRID2(17), GRIK1(17), GRIK2(12), GRIK3(16), GRIK4(7), GRIK5(17), GRIN1(4), GRIN2A(25), GRIN2B(25), GRIN2C(6), GRIN2D(5), GRIN3A(15), GRIN3B(3), GRM1(26), GRM2(9), GRM3(18), GRM4(11), GRM5(26), GRM6(15), GRM7(19), GRM8(19), GRPR(4), GZMA(6), HCRTR2(11), HRH1(10), HRH2(4), HRH3(2), HRH4(5), HTR1A(14), HTR1B(6), HTR1D(6), HTR1E(11), HTR1F(11), HTR2A(11), HTR2B(2), HTR2C(16), HTR4(6), HTR5A(12), HTR6(4), HTR7(5), LEP(2), LEPR(12), LHB(2), LHCGR(17), LTB4R(2), LTB4R2(4), MAS1(3), MC1R(3), MC2R(4), MC3R(5), MC4R(5), MC5R(14), MCHR1(8), MCHR2(3), MLNR(3), MTNR1A(5), MTNR1B(4), NMBR(4), NMUR1(4), NMUR2(8), NPBWR2(1), NPFFR1(1), NPFFR2(13), NPY1R(9), NPY2R(5), NPY5R(13), NR3C1(17), NTSR1(5), NTSR2(1), OPRD1(1), OPRK1(10), OPRL1(3), OPRM1(11), OXTR(4), P2RX1(5), P2RX2(3), P2RX3(8), P2RX4(1), P2RX5(5), P2RX7(1), P2RY1(3), P2RY10(8), P2RY11(7), P2RY13(2), P2RY14(6), P2RY2(3), P2RY4(5), P2RY6(4), P2RY8(7), PARD3(19), PRL(9), PRLHR(1), PRLR(5), PRSS1(2), PRSS3(2), PTAFR(4), PTGDR(9), PTGER2(3), PTGER3(4), PTGER4(12), PTGFR(10), PTGIR(3), PTH2R(12), RXFP1(21), RXFP2(14), SCTR(5), SSTR1(9), SSTR2(3), SSTR3(3), SSTR4(10), SSTR5(2), TAAR1(7), TAAR2(7), TAAR5(5), TAAR6(6), TAAR8(3), TACR1(7), TACR2(3), TACR3(9), THRA(4), THRB(4), TRHR(3), TRPV1(2), TSHB(3), TSHR(8), TSPO(2), VIPR1(3), VIPR2(4)	77867473	1688	161	1631	650	515	713	274	19	159	8	0.271	1.000	1.000
283	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	75	ACP1(3), ACTB(3), ACTG1(6), ACTN1(9), ACTN2(16), ACTN4(8), ACVR1B(8), ACVR1C(6), BAIAP2(5), CDC42(3), CDH1(14), CREBBP(32), CSNK2A1(9), CSNK2A2(4), CTNNA1(17), CTNNA2(16), CTNNA3(13), CTNNB1(80), CTNND1(27), EGFR(12), EP300(32), ERBB2(10), FARP2(14), FER(14), FGFR1(9), FYN(5), IGF1R(13), INSR(18), IQGAP1(12), LEF1(8), LMO7(26), MAP3K7(9), MAPK1(2), MAPK3(3), MET(17), MLLT4(21), NLK(5), PARD3(19), PTPN1(5), PTPN6(5), PTPRB(28), PTPRF(26), PTPRJ(18), PTPRM(15), PVRL1(10), PVRL2(5), PVRL3(7), PVRL4(4), RAC1(1), RAC2(2), RHOA(3), SMAD2(9), SMAD3(7), SMAD4(5), SNAI1(2), SNAI2(5), SORBS1(18), SRC(3), SSX2IP(11), TCF7(3), TCF7L1(4), TCF7L2(11), TGFBR1(6), TGFBR2(6), TJP1(24), VCL(11), WAS(11), WASF1(3), WASF2(3), WASF3(8), WASL(8), YES1(8)	43898605	823	160	746	210	244	294	162	11	106	6	0.000125	1.000	1.000
284	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	82	ABL1(8), ATM(54), BUB1(10), BUB1B(6), BUB3(4), CCNA1(5), CCNA2(7), CCNB1(8), CCNB2(5), CCNB3(33), CCND2(9), CCND3(4), CCNE1(6), CCNE2(8), CCNH(7), CDAN1(9), CDC14A(6), CDC14B(6), CDC20(4), CDC25A(8), CDC25B(3), CDC25C(5), CDC6(3), CDC7(11), CDH1(14), CDK2(2), CDK4(2), CDKN1A(1), CDKN2A(1), CHEK1(2), CHEK2(13), DTX4(4), E2F1(9), E2F2(3), E2F3(4), E2F4(3), E2F5(5), E2F6(1), EP300(32), ESPL1(12), GSK3B(13), HDAC1(5), HDAC2(3), HDAC3(12), HDAC4(14), HDAC5(12), HDAC6(24), HDAC8(1), MAD1L1(12), MAD2L1(3), MAD2L2(2), MCM2(7), MCM3(9), MCM4(11), MCM5(8), MCM6(6), MCM7(6), MDM2(5), MPEG1(9), MPL(7), PCNA(3), PLK1(4), PRKDC(54), PTPRA(10), PTTG1(2), RB1(26), RBL1(13), SKP2(6), SMAD4(5), TBC1D8(15), TFDP1(13), TGFB1(1), TP53(74), WEE1(2)	40838039	734	157	692	196	220	236	135	5	128	10	0.0178	1.000	1.000
285	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(21), ADCY2(19), ADCY3(12), ADCY4(12), ADCY5(15), ADCY6(14), ADCY7(9), ADCY8(22), ADCY9(27), ADRA1A(12), ADRA1B(6), ADRA1D(1), ADRB2(7), ADRB3(3), ANXA6(12), ARRB1(4), ARRB2(5), ATP1A4(24), ATP1B1(6), ATP1B2(5), ATP1B3(3), ATP2A2(8), ATP2A3(11), ATP2B1(15), ATP2B2(12), ATP2B3(16), CACNA1A(19), CACNA1B(31), CACNA1C(38), CACNA1D(28), CACNA1E(58), CACNA1S(34), CACNB1(11), CACNB3(5), CALM1(2), CALM2(3), CALR(3), CAMK1(3), CAMK2A(9), CAMK2B(4), CAMK2D(5), CAMK2G(5), CAMK4(5), CASQ1(7), CASQ2(9), CHRM1(6), CHRM2(10), CHRM3(8), CHRM4(9), CHRM5(9), GJA1(5), GJA4(1), GJA5(6), GJB1(3), GJB2(3), GJB3(4), GJB4(6), GJB5(2), GJB6(3), GNA11(2), GNAI2(6), GNAI3(4), GNAO1(6), GNAQ(3), GNAZ(4), GNB1(2), GNB2(5), GNB3(2), GNB4(4), GNB5(3), GNG12(1), GNG13(2), GNG2(2), GNG3(2), GNG4(5), GNG7(1), GNGT1(1), GRK4(10), GRK5(8), GRK6(2), ITPR1(34), ITPR2(35), ITPR3(22), KCNB1(13), KCNJ3(9), KCNJ5(7), MIB1(9), MYCBP(2), NME7(4), PEA15(2), PKIA(1), PLCB3(11), PLN(2), PRKACA(6), PRKACB(3), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PRKCA(11), PRKCD(5), PRKCE(10), PRKCG(8), PRKCH(10), PRKCQ(9), PRKCZ(2), PRKD1(8), RGS1(6), RGS10(2), RGS11(1), RGS14(4), RGS16(5), RGS17(4), RGS18(3), RGS19(3), RGS2(3), RGS20(2), RGS3(8), RGS4(6), RGS5(4), RGS6(10), RGS7(9), RGS9(11), RYR1(73), RYR2(109), RYR3(93), SLC8A1(13), SLC8A3(13), USP5(13), YWHAH(3), YWHAQ(1)	69521324	1367	153	1337	521	472	502	216	11	155	11	0.456	1.000	1.000
286	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	ARAF(12), BRAF(10), CACNA1A(19), CRH(1), CRHR1(3), GNA11(2), GNA12(7), GNA13(7), GNAI1(5), GNAI2(6), GNAI3(4), GNAO1(6), GNAQ(3), GNAS(24), GNAZ(4), GRIA1(12), GRIA2(21), GRIA3(21), GRID2(17), GRM1(26), GRM5(26), GUCY1A2(10), GUCY1A3(11), GUCY1B3(7), GUCY2C(14), GUCY2D(7), GUCY2F(27), HRAS(1), IGF1(5), IGF1R(13), ITPR1(34), ITPR2(35), ITPR3(22), KRAS(52), LYN(9), MAP2K1(2), MAP2K2(5), MAPK1(2), MAPK3(3), NOS1(18), NOS3(11), NPR1(11), NPR2(11), NRAS(9), PLA2G12A(1), PLA2G12B(4), PLA2G2D(2), PLA2G2E(5), PLA2G2F(3), PLA2G3(7), PLA2G4A(13), PLA2G5(1), PLA2G6(9), PLCB1(5), PLCB2(8), PLCB3(11), PLCB4(19), PPP2CA(6), PPP2CB(4), PPP2R1A(31), PPP2R1B(5), PPP2R2A(10), PPP2R2B(12), PPP2R2C(2), PRKCA(11), PRKCG(8), PRKG1(11), PRKG2(11), RAF1(9), RYR1(73)	40168024	836	149	760	261	252	348	127	9	98	2	0.0235	1.000	1.000
287	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	135	ACTB(3), ACTG1(6), CHAD(3), COL11A1(35), COL11A2(10), COL17A1(20), COL1A1(12), COL1A2(24), COL2A1(16), COL3A1(18), COL4A1(21), COL4A2(14), COL4A4(23), COL4A6(31), COL5A1(30), COL5A2(21), COL5A3(19), COL6A1(5), COL6A2(12), COL6A3(44), COL6A6(27), COMP(7), DES(7), DSC1(18), DSC2(13), DSC3(20), DSG1(24), DSG2(15), DSG3(23), DSG4(15), FN1(42), GJA1(5), GJA10(10), GJA3(5), GJA4(1), GJA5(6), GJA8(6), GJA9(15), GJB1(3), GJB2(3), GJB3(4), GJB4(6), GJB5(2), GJB6(3), GJB7(8), GJC1(2), GJC3(2), GJD2(8), GJD4(3), IBSP(7), INA(4), ITGA6(12), ITGB4(8), KRT1(8), KRT10(3), KRT12(8), KRT13(6), KRT14(9), KRT15(10), KRT16(8), KRT17(4), KRT18(1), KRT19(6), KRT2(7), KRT20(4), KRT23(10), KRT24(5), KRT25(7), KRT27(4), KRT28(4), KRT3(9), KRT31(8), KRT32(10), KRT33A(7), KRT33B(5), KRT34(8), KRT35(9), KRT36(6), KRT37(8), KRT38(8), KRT39(14), KRT4(10), KRT40(5), KRT5(7), KRT6A(4), KRT6B(9), KRT6C(8), KRT7(3), KRT71(5), KRT72(6), KRT73(7), KRT74(1), KRT75(4), KRT76(6), KRT77(7), KRT78(5), KRT79(5), KRT8(7), KRT81(4), KRT82(1), KRT83(4), KRT84(7), KRT85(6), KRT86(1), KRT9(8), LAMA1(31), LAMA2(61), LAMA3(29), LAMA4(16), LAMA5(17), LAMB1(23), LAMB2(26), LAMB3(15), LAMB4(30), LAMC1(18), LAMC2(17), LAMC3(17), LMNA(7), LMNB1(5), LMNB2(4), NES(27), RELN(48), SPP1(2), THBS1(10), THBS2(20), THBS3(3), THBS4(12), TNC(26), TNN(19), TNR(14), TNXB(19), VIM(8), VTN(3), VWF(25)	88632952	1579	144	1545	531	473	613	248	19	210	16	0.113	1.000	1.000
288	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	95	ADCY1(21), ADCY2(19), ADCY3(12), ADCY4(12), ADCY5(15), ADCY6(14), ADCY7(9), ADCY8(22), ADCY9(27), ATF4(3), CACNA1C(38), CACNA1D(28), CACNA1F(38), CACNA1S(34), CALM1(2), CALM2(3), CALML3(3), CALML6(4), CAMK2A(9), CAMK2B(4), CAMK2D(5), CAMK2G(5), CDC42(3), CGA(1), EGFR(12), ELK1(3), GNA11(2), GNAQ(3), GNAS(24), GNRH1(1), GNRH2(1), GNRHR(4), GRB2(3), HBEGF(2), HRAS(1), ITPR1(34), ITPR2(35), ITPR3(22), JUN(1), KRAS(52), LHB(2), MAP2K1(2), MAP2K2(5), MAP2K3(7), MAP2K4(9), MAP2K6(10), MAP2K7(4), MAP3K1(30), MAP3K2(12), MAP3K3(8), MAP3K4(21), MAPK1(2), MAPK10(10), MAPK11(3), MAPK12(2), MAPK13(4), MAPK14(4), MAPK3(3), MAPK7(14), MAPK8(11), MAPK9(4), MMP14(7), MMP2(7), NRAS(9), PLA2G12A(1), PLA2G12B(4), PLA2G2D(2), PLA2G2E(5), PLA2G2F(3), PLA2G3(7), PLA2G4A(13), PLA2G5(1), PLA2G6(9), PLCB1(5), PLCB2(8), PLCB3(11), PLCB4(19), PLD1(13), PLD2(10), PRKACA(6), PRKACB(3), PRKACG(9), PRKCA(11), PRKCD(5), PRKX(2), PTK2B(15), RAF1(9), SOS1(13), SOS2(17), SRC(3)	46763646	925	142	857	278	313	329	147	13	114	9	0.00245	1.000	1.000
289	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(56), AXIN1(9), CCND1(14), CCND2(9), CCND3(4), CSNK1E(3), CTNNB1(80), DVL1(3), DVL2(10), DVL3(9), FBXW2(4), FOSL1(3), FZD1(3), FZD10(9), FZD2(8), FZD3(9), FZD5(2), FZD6(13), FZD7(4), FZD8(2), FZD9(6), GSK3B(13), JUN(1), LDLR(7), MAPK10(10), MAPK9(4), MYC(8), PAFAH1B1(3), PPP2R5C(7), PPP2R5E(8), PRKCA(11), PRKCD(5), PRKCE(10), PRKCG(8), PRKCH(10), PRKCI(6), PRKCQ(9), PRKCZ(2), PRKD1(8), RAC1(1), RHOA(3), SFRP4(9), TCF7(3), WNT1(1), WNT10A(2), WNT10B(1), WNT11(5), WNT16(7), WNT2(3), WNT2B(6), WNT3(3), WNT4(1), WNT5A(6), WNT5B(3), WNT6(1), WNT7A(3), WNT7B(2)	20506676	450	140	381	138	132	172	86	4	53	3	0.0546	1.000	1.000
290	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(11), CD36(8), CD44(5), CD47(6), CHAD(3), COL11A1(35), COL11A2(10), COL1A1(12), COL1A2(24), COL2A1(16), COL3A1(18), COL4A1(21), COL4A2(14), COL4A4(23), COL4A6(31), COL5A1(30), COL5A2(21), COL5A3(19), COL6A1(5), COL6A2(12), COL6A3(44), COL6A6(27), DAG1(6), FN1(42), FNDC1(34), FNDC3A(7), FNDC4(3), FNDC5(2), GP5(3), GP6(2), GP9(1), HMMR(12), HSPG2(22), IBSP(7), ITGA1(17), ITGA10(9), ITGA11(7), ITGA2(19), ITGA2B(11), ITGA3(4), ITGA4(10), ITGA5(10), ITGA6(12), ITGA7(14), ITGA8(19), ITGA9(16), ITGAV(10), ITGB1(8), ITGB3(11), ITGB4(8), ITGB5(8), ITGB6(7), ITGB7(4), ITGB8(9), LAMA1(31), LAMA2(61), LAMA3(29), LAMA4(16), LAMA5(17), LAMB1(23), LAMB2(26), LAMB3(15), LAMB4(30), LAMC1(18), LAMC2(17), LAMC3(17), RELN(48), SDC1(1), SDC2(1), SDC3(2), SDC4(4), SPP1(2), SV2A(14), SV2B(13), SV2C(17), THBS1(10), THBS2(20), THBS3(3), THBS4(12), TNC(26), TNN(19), TNR(14), TNXB(19), VTN(3), VWF(25)	79695637	1302	136	1274	450	376	505	201	15	188	17	0.306	1.000	1.000
291	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	56	ALG2(2), BAK1(3), BAX(2), BFAR(7), BTK(12), CAD(25), CASP10(8), CASP3(4), CASP8(21), CD7(3), CDK2AP1(1), CSNK1A1(3), DAXX(9), DEDD(2), DEDD2(2), DIABLO(3), EGFR(12), EPHB2(11), FADD(1), FAF1(10), FAIM2(3), MAP2K4(9), MAP2K7(4), MAP3K1(30), MAP3K5(25), MAPK1(2), MAPK10(10), MAPK8(11), MAPK8IP1(4), MAPK8IP2(1), MAPK8IP3(9), MAPK9(4), MET(17), NFAT5(16), NFKB1(10), NFKB2(9), NFKBIA(3), NFKBIB(1), NFKBIE(6), NFKBIL1(1), NR0B2(2), PFN1(1), PFN2(2), PTPN13(29), RALBP1(6), RIPK1(8), ROCK1(22), SMPD1(4), TP53(74), TPX2(12), TRAF2(3), TUFM(2)	24662302	481	136	447	122	125	176	80	1	93	6	0.00921	1.000	1.000
292	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	136	ACTA1(5), ACTA2(7), ADCY1(21), ADCY2(19), ADCY3(12), ADCY4(12), ADCY5(15), ADCY6(14), ADCY7(9), ADCY8(22), ADCY9(27), ADM(2), ARRB1(4), ARRB2(5), ATF1(6), ATF2(8), ATF3(3), ATF4(3), ATF5(6), ATP2A2(8), ATP2A3(11), CACNB3(5), CALCA(1), CALM1(2), CALM2(3), CAMK2A(9), CAMK2B(4), CAMK2D(5), CAMK2G(5), CNN1(3), CNN2(1), CORIN(12), CRH(1), CRHR1(3), DGKZ(10), ETS2(6), FOS(3), GABPA(7), GABPB2(12), GBA2(9), GJA1(5), GNAQ(3), GNB1(2), GNB2(5), GNB3(2), GNB4(4), GNB5(3), GNG12(1), GNG13(2), GNG2(2), GNG3(2), GNG4(5), GNG7(1), GNGT1(1), GRK4(10), GRK5(8), GRK6(2), GSTO1(3), GUCA2B(1), GUCY1A3(11), IGFBP1(4), IGFBP2(4), IGFBP3(4), IGFBP4(3), IGFBP6(2), IL1B(2), IL6(5), ITPR1(34), ITPR2(35), ITPR3(22), JUN(1), MIB1(9), MYL2(2), MYLK2(8), NFKB1(10), NOS1(18), NOS3(11), OXTR(4), PDE4B(9), PDE4D(9), PKIA(1), PLCB3(11), PLCD1(4), PLCG1(12), PLCG2(27), PRKACA(6), PRKACB(3), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PRKCA(11), PRKCD(5), PRKCE(10), PRKCH(10), PRKCQ(9), PRKCZ(2), PRKD1(8), RAMP1(1), RAMP3(2), RGS1(6), RGS10(2), RGS11(1), RGS14(4), RGS16(5), RGS17(4), RGS18(3), RGS19(3), RGS2(3), RGS20(2), RGS3(8), RGS4(6), RGS5(4), RGS6(10), RGS7(9), RGS9(11), RLN1(1), RYR1(73), RYR2(109), RYR3(93), SLC8A1(13), SP1(7), TNXB(19), USP5(13), YWHAH(3), YWHAQ(1)	62417276	1139	135	1111	424	375	422	192	7	133	10	0.520	1.000	1.000
293	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY1(21), ADCY2(19), ADCY3(12), ADCY4(12), ADCY5(15), ADCY6(14), ADCY7(9), ADCY8(22), ADCY9(27), AKAP1(9), AKAP10(9), AKAP11(23), AKAP12(21), AKAP2(11), AKAP3(21), AKAP4(15), AKAP5(3), AKAP6(34), AKAP7(7), AKAP8(7), AKAP9(52), ARHGEF1(12), CALM1(2), CALM2(3), CHMP1B(1), GNA11(2), GNA12(7), GNA13(7), GNA14(7), GNA15(1), GNAI2(6), GNAI3(4), GNAL(6), GNAO1(6), GNAQ(3), GNAZ(4), GNB1(2), GNB2(5), GNB3(2), GNB5(3), GNG12(1), GNG13(2), GNG3(2), GNG4(5), GNG7(1), GNGT1(1), GNGT2(3), HRAS(1), IL18BP(1), ITPR1(34), KCNJ3(9), KRAS(52), NRAS(9), PALM2(10), PDE1A(14), PDE1B(7), PDE1C(11), PDE4A(8), PDE4B(9), PDE4C(2), PDE4D(9), PDE7A(1), PDE7B(7), PDE8A(7), PDE8B(19), PLCB3(11), PPP3CA(4), PPP3CC(6), PRKACA(6), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PRKCA(11), PRKCD(5), PRKCE(10), PRKCG(8), PRKCH(10), PRKCI(6), PRKCQ(9), PRKCZ(2), PRKD1(8), PRKD3(11), RHOA(3), RRAS(3), SLC9A1(7), USP5(13)	42506319	831	134	771	294	255	289	169	7	105	6	0.442	1.000	1.000
294	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	246	ACVR1(8), ACVR1B(8), ACVR2A(7), ACVR2B(5), AMHR2(3), BMP2(6), BMP7(12), BMPR1A(5), BMPR1B(6), BMPR2(12), CCL1(1), CCL13(2), CCL14(1), CCL15(1), CCL16(1), CCL17(1), CCL18(1), CCL21(1), CCL23(3), CCL24(3), CCL25(1), CCL28(2), CCL4(5), CCL5(2), CCL7(4), CCL8(2), CCR1(4), CCR2(5), CCR3(4), CCR4(5), CCR5(6), CCR6(5), CCR7(6), CCR8(6), CCR9(4), CD27(4), CD40(1), CD40LG(6), CD70(2), CLCF1(1), CNTF(3), CNTFR(4), CRLF2(5), CSF1(6), CSF1R(8), CSF2(1), CSF2RA(10), CSF2RB(14), CSF3(1), CSF3R(7), CX3CL1(3), CX3CR1(6), CXCL1(3), CXCL10(2), CXCL12(3), CXCL13(2), CXCL2(2), CXCL3(1), CXCL5(3), CXCL9(2), CXCR3(5), CXCR4(1), CXCR6(1), EDA(4), EDA2R(6), EDAR(5), EGF(19), EGFR(12), EPO(3), EPOR(4), FAS(8), FASLG(7), FLT1(20), FLT3(16), FLT3LG(2), FLT4(8), GDF5(7), GH1(2), GH2(1), GHR(8), HGF(14), IFNA1(2), IFNA10(3), IFNA13(3), IFNA14(4), IFNA16(3), IFNA17(3), IFNA2(2), IFNA21(1), IFNA4(3), IFNA5(5), IFNA6(2), IFNA7(1), IFNA8(3), IFNAR1(7), IFNAR2(8), IFNB1(3), IFNG(10), IFNGR1(4), IFNGR2(4), IFNK(2), IFNW1(3), IL10(4), IL10RA(4), IL10RB(6), IL11(2), IL11RA(5), IL12A(5), IL12B(2), IL12RB1(13), IL12RB2(10), IL13RA1(11), IL15(2), IL17RA(5), IL17RB(5), IL18(2), IL18R1(9), IL18RAP(14), IL19(2), IL1B(2), IL1R1(5), IL1R2(5), IL1RAP(8), IL2(2), IL20(9), IL20RA(4), IL21(3), IL21R(7), IL22RA1(4), IL22RA2(1), IL23A(4), IL23R(5), IL24(5), IL25(2), IL26(3), IL2RA(4), IL2RB(3), IL2RG(11), IL3(2), IL3RA(9), IL4(1), IL4R(6), IL5(2), IL5RA(9), IL6(5), IL6R(7), IL6ST(11), IL7(1), IL7R(12), IL9(1), IL9R(3), INHBA(7), INHBB(2), INHBC(3), INHBE(6), KDR(26), KIT(23), KITLG(3), LEP(2), LEPR(12), LIF(3), LIFR(27), LTA(3), LTBR(5), MET(17), MPL(7), NGFR(3), OSM(2), OSMR(13), PDGFB(2), PDGFC(3), PDGFRA(24), PDGFRB(12), PF4(1), PF4V1(1), PLEKHO2(6), PPBP(1), PRL(9), PRLR(5), RELT(2), TGFB1(1), TGFB2(5), TGFB3(9), TGFBR1(6), TGFBR2(6), TNFRSF10A(2), TNFRSF10B(5), TNFRSF10C(4), TNFRSF10D(6), TNFRSF11A(4), TNFRSF11B(13), TNFRSF13B(3), TNFRSF14(2), TNFRSF17(1), TNFRSF19(4), TNFRSF1A(4), TNFRSF1B(2), TNFRSF21(5), TNFRSF25(2), TNFRSF8(6), TNFRSF9(2), TNFSF10(1), TNFSF11(7), TNFSF12(6), TNFSF13(3), TNFSF13B(5), TNFSF14(2), TNFSF15(3), TNFSF18(4), TNFSF4(4), TNFSF8(1), TNFSF9(6), TPO(14), TSLP(2), VEGFA(2), VEGFB(3), VEGFC(6), XCL2(2), XCR1(3)	63931396	1130	132	1109	352	280	442	224	7	172	5	0.0340	1.000	1.000
295	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	127	ALCAM(7), CADM1(4), CADM3(10), CD2(4), CD22(14), CD226(6), CD274(1), CD276(2), CD28(3), CD34(1), CD4(6), CD40(1), CD40LG(6), CD58(2), CD6(6), CD80(5), CD86(5), CD8A(2), CD8B(1), CDH1(14), CDH15(8), CDH2(18), CDH3(5), CDH4(17), CDH5(6), CLDN1(3), CLDN10(7), CLDN11(2), CLDN15(5), CLDN16(4), CLDN17(4), CLDN18(7), CLDN19(2), CLDN2(3), CLDN20(3), CLDN22(2), CLDN8(4), CLDN9(3), CNTN1(18), CNTN2(6), CNTNAP1(12), CNTNAP2(31), CTLA4(2), ESAM(1), F11R(1), GLG1(8), HLA-A(1), HLA-B(2), HLA-C(2), HLA-DMA(3), HLA-DOA(2), HLA-DOB(2), HLA-DPB1(1), HLA-DQA1(1), HLA-DQA2(1), HLA-DQB1(1), HLA-DRA(1), HLA-DRB5(1), HLA-E(1), HLA-F(2), HLA-G(2), ICAM1(2), ICAM2(3), ICAM3(3), ICOS(3), ICOSLG(2), ITGA4(10), ITGA6(12), ITGA8(19), ITGA9(16), ITGAL(17), ITGAM(21), ITGAV(10), ITGB1(8), ITGB2(15), ITGB7(4), ITGB8(9), JAM2(9), JAM3(2), L1CAM(20), MADCAM1(2), MAG(7), MPZ(3), MPZL1(3), NCAM1(10), NCAM2(33), NEGR1(7), NEO1(17), NFASC(31), NLGN1(9), NLGN2(8), NLGN3(25), NRCAM(15), NRXN1(34), NRXN2(16), NRXN3(27), OCLN(2), PDCD1(3), PDCD1LG2(1), PTPRC(17), PTPRF(26), PTPRM(15), PVR(3), PVRL1(10), PVRL2(5), PVRL3(7), SDC1(1), SDC2(1), SDC3(2), SDC4(4), SELE(5), SELL(5), SELP(13), SELPLG(9), SIGLEC1(11), SPN(1), VCAM1(12), VCAN(64)	51647538	954	132	926	315	292	368	160	4	121	9	0.0264	1.000	1.000
296	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	91	ADCY1(21), ADCY2(19), ADCY3(12), ADCY4(12), ADCY5(15), ADCY6(14), ADCY7(9), ADCY8(22), ADCY9(27), CSNK1D(3), DRD1(6), DRD2(8), EGF(19), EGFR(12), GJA1(5), GJD2(8), GNA11(2), GNAI1(5), GNAI2(6), GNAI3(4), GNAQ(3), GNAS(24), GRB2(3), GRM1(26), GRM5(26), GUCY1A2(10), GUCY1A3(11), GUCY1B3(7), GUCY2C(14), GUCY2D(7), GUCY2F(27), HRAS(1), HTR2A(11), HTR2B(2), HTR2C(16), ITPR1(34), ITPR2(35), ITPR3(22), KRAS(52), MAP2K1(2), MAP2K2(5), MAP2K5(3), MAP3K2(12), MAPK1(2), MAPK3(3), MAPK7(14), NPR1(11), NPR2(11), NRAS(9), PDGFA(3), PDGFB(2), PDGFC(3), PDGFD(8), PDGFRA(24), PDGFRB(12), PLCB1(5), PLCB2(8), PLCB3(11), PLCB4(19), PRKACA(6), PRKACB(3), PRKACG(9), PRKCA(11), PRKCG(8), PRKG1(11), PRKG2(11), PRKX(2), RAF1(9), SOS1(13), SOS2(17), SRC(3), TJP1(24), TUBA1A(9), TUBA1B(3), TUBA1C(5), TUBA3C(5), TUBA3D(4), TUBA3E(10), TUBA4A(11), TUBA8(7), TUBAL3(6), TUBB1(5), TUBB2A(2), TUBB2B(2), TUBB3(6), TUBB6(5), TUBB8(4)	47468487	938	132	871	287	280	357	178	12	107	4	0.00734	1.000	1.000
297	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	67	ADCY1(21), ADCY8(22), ARAF(12), ATF4(3), BRAF(10), CACNA1C(38), CALM1(2), CALM2(3), CALML3(3), CALML6(4), CAMK2A(9), CAMK2B(4), CAMK2D(5), CAMK2G(5), CAMK4(5), CREBBP(32), EP300(32), GNAQ(3), GRIA1(12), GRIA2(21), GRIN1(4), GRIN2A(25), GRIN2B(25), GRIN2C(6), GRIN2D(5), GRM1(26), GRM5(26), HRAS(1), ITPR1(34), ITPR2(35), ITPR3(22), KRAS(52), MAP2K1(2), MAP2K2(5), MAPK1(2), MAPK3(3), NRAS(9), PLCB1(5), PLCB2(8), PLCB3(11), PLCB4(19), PPP1CA(2), PPP1CB(9), PPP1CC(2), PPP1R12A(8), PPP1R1A(2), PPP3CA(4), PPP3CB(6), PPP3CC(6), PPP3R1(1), PRKACA(6), PRKACB(3), PRKACG(9), PRKCA(11), PRKCG(8), PRKX(2), RAF1(9), RAP1A(4), RAP1B(2), RAPGEF3(8), RPS6KA1(1), RPS6KA2(13), RPS6KA3(19), RPS6KA6(19)	36763828	725	131	661	232	213	271	142	6	90	3	0.0678	1.000	1.000
298	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	66	APAF1(17), BAD(1), BAK1(3), BAX(2), BCL2L1(4), BCL2L11(6), BID(2), BIRC2(10), BIRC3(5), BIRC5(5), BNIP3L(1), CASP1(8), CASP10(8), CASP2(6), CASP3(4), CASP4(5), CASP6(7), CASP7(1), CASP8(21), CASP9(3), CHUK(8), CYCS(2), DFFB(4), FADD(1), FAS(8), FASLG(7), GZMB(4), HELLS(12), IKBKB(13), IKBKG(3), IRF1(1), IRF2(5), IRF3(2), IRF4(8), IRF5(6), IRF6(9), IRF7(1), JUN(1), LTA(3), MAP2K4(9), MAP3K1(30), MAPK10(10), MDM2(5), MYC(8), NFKB1(10), NFKBIA(3), NFKBIB(1), NFKBIE(6), PLEKHG5(5), PRF1(8), RELA(6), RIPK1(8), TNFRSF10B(5), TNFRSF1A(4), TNFRSF1B(2), TNFRSF21(5), TNFRSF25(2), TNFSF10(1), TP53(74), TP73(5), TRAF1(5), TRAF2(3), TRAF3(5)	20246836	437	127	405	108	109	162	74	3	88	1	0.00729	1.000	1.000
299	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT1(4), AKT2(6), AKT3(11), ANKRD6(8), APC(56), AXIN1(9), AXIN2(9), CER1(4), CSNK1A1(3), CTNNB1(80), DACT1(14), DKK1(3), DKK2(3), DKK3(1), DKK4(3), DVL1(3), FSTL1(4), GSK3A(10), GSK3B(13), LRP1(51), MVP(14), NKD1(3), PSEN1(5), PTPRA(10), SENP2(11), SFRP1(6), TSHB(3), WIF1(5)	14398562	352	126	286	95	110	149	53	2	35	3	0.0114	1.000	1.000
300	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	141	ADA(2), ADCY1(21), ADCY2(19), ADCY3(12), ADCY4(12), ADCY5(15), ADCY6(14), ADCY7(9), ADCY8(22), ADCY9(27), ADK(2), ADSL(8), ADSS(6), ADSSL1(5), AK1(1), AK2(3), AK5(8), AK7(13), ALLC(8), AMPD1(23), AMPD2(6), AMPD3(7), ATIC(7), CANT1(1), DCK(3), ENPP1(12), ENPP3(17), ENTPD1(4), ENTPD3(5), ENTPD4(2), ENTPD5(2), ENTPD6(11), ENTPD8(5), FHIT(4), GART(9), GDA(4), GMPR(6), GMPR2(3), GMPS(14), GUCY1A2(10), GUCY1A3(11), GUCY1B3(7), GUCY2C(14), GUCY2D(7), GUCY2F(27), GUK1(5), HPRT1(2), IMPDH1(6), ITPA(1), NME1(2), NME2(3), NME4(1), NME6(2), NME7(4), NPR1(11), NPR2(11), NT5C(1), NT5C1A(2), NT5C1B(8), NT5C2(6), NT5E(6), NT5M(2), NUDT2(2), NUDT5(2), NUDT9(1), PAICS(4), PAPSS1(8), PAPSS2(7), PDE10A(14), PDE11A(12), PDE1A(14), PDE1C(11), PDE2A(14), PDE3B(15), PDE4A(8), PDE4B(9), PDE4C(2), PDE4D(9), PDE5A(14), PDE6D(2), PDE6G(1), PDE6H(1), PDE7A(1), PDE7B(7), PDE8A(7), PDE8B(19), PDE9A(8), PFAS(11), PKLR(6), PNPT1(7), POLA1(29), POLA2(3), POLD1(10), POLD2(6), POLD3(6), POLD4(1), POLE(47), POLE2(4), POLE3(3), POLE4(1), POLR1A(15), POLR1B(16), POLR1C(2), POLR1D(3), POLR2A(21), POLR2B(21), POLR2C(5), POLR2D(3), POLR2E(1), POLR2F(1), POLR2H(3), POLR2J(1), POLR2K(2), POLR3A(7), POLR3B(14), POLR3G(3), POLR3GL(2), POLR3H(4), PPAT(9), PRIM1(3), PRPS1(2), PRPS1L1(5), PRPS2(4), PRUNE(5), RFC5(8), RRM1(2), RRM2(6), RRM2B(5), XDH(14)	59133569	1014	125	983	308	313	343	188	10	156	4	0.0338	1.000	1.000
301	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	149	ADORA1(3), ADORA2A(6), ADORA2B(1), ADORA3(4), ADRA1A(12), ADRA1B(6), ADRA1D(1), ADRA2A(6), ADRA2C(2), ADRB2(7), ADRB3(3), AGTR1(4), AGTR2(11), AVPR1A(7), AVPR1B(3), AVPR2(4), BDKRB1(3), BDKRB2(8), BRS3(17), C3AR1(9), CCKAR(9), CCKBR(3), CCR1(4), CCR2(5), CCR3(4), CCR4(5), CCR5(6), CCR6(5), CCR7(6), CCR8(6), CCR9(4), CCRL2(1), CHML(10), CHRM1(6), CHRM2(10), CHRM3(8), CHRM4(9), CHRM5(9), CMKLR1(9), CNR1(11), CNR2(6), CX3CR1(6), CXCR3(5), CXCR4(1), DRD1(6), DRD2(8), DRD3(6), DRD5(11), EDNRA(5), EDNRB(4), F2R(6), F2RL1(4), F2RL2(2), FPR1(2), FSHR(15), GALR1(3), GALR3(2), GALT(3), GHSR(8), GNB2L1(1), GPR17(6), GPR173(6), GPR174(12), GPR3(5), GPR35(3), GPR37(9), GPR37L1(5), GPR4(9), GPR50(8), GPR6(4), GPR63(5), GPR83(3), GPR85(7), GPR87(7), GRPR(4), HCRTR2(11), HRH1(10), HRH2(4), HRH3(2), HTR1A(14), HTR1B(6), HTR1D(6), HTR1E(11), HTR1F(11), HTR2A(11), HTR2B(2), HTR2C(16), HTR4(6), HTR5A(12), HTR6(4), HTR7(5), LHCGR(17), LTB4R(2), MAS1(3), MC1R(3), MC3R(5), MC4R(5), MC5R(14), MLNR(3), MTNR1A(5), MTNR1B(4), NMBR(4), NMUR1(4), NMUR2(8), NPY1R(9), NPY2R(5), NPY5R(13), NTSR1(5), NTSR2(1), OPN1SW(6), OPN3(2), OPRD1(1), OPRK1(10), OPRL1(3), OPRM1(11), OXTR(4), P2RY1(3), P2RY10(8), P2RY11(7), P2RY12(5), P2RY13(2), P2RY14(6), P2RY2(3), P2RY6(4), PTAFR(4), PTGDR(9), PTGER2(3), PTGER4(12), PTGFR(10), PTGIR(3), RGR(6), RHO(4), RRH(2), SSTR1(9), SSTR2(3), SSTR3(3), SSTR4(10), SUCNR1(3), TRHR(3)	39736749	844	124	820	320	285	339	141	11	66	2	0.0615	1.000	1.000
302	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	86	ACVR1(8), ACVR1B(8), ACVR1C(6), ACVR2A(7), ACVR2B(5), ACVRL1(2), AMHR2(3), BMP2(6), BMP4(10), BMP5(14), BMP6(5), BMP7(12), BMP8A(3), BMP8B(1), BMPR1A(5), BMPR1B(6), BMPR2(12), CHRD(12), COMP(7), CREBBP(32), CUL1(13), DCN(11), E2F4(3), E2F5(5), EP300(32), FST(4), GDF5(7), GDF6(3), ID1(2), ID2(1), IFNG(10), INHBA(7), INHBB(2), INHBC(3), INHBE(6), LEFTY1(4), LEFTY2(1), LTBP1(17), MAPK1(2), MAPK3(3), MYC(8), NODAL(3), NOG(2), PITX2(8), PPP2CA(6), PPP2CB(4), PPP2R1A(31), PPP2R1B(5), PPP2R2A(10), PPP2R2B(12), PPP2R2C(2), RBL1(13), RBL2(19), RBX1(1), RHOA(3), ROCK1(22), ROCK2(17), RPS6KB1(3), RPS6KB2(4), SMAD1(2), SMAD2(9), SMAD3(7), SMAD4(5), SMAD5(9), SMAD7(3), SMAD9(2), SMURF1(12), SMURF2(8), SP1(7), TFDP1(13), TGFB1(1), TGFB2(5), TGFB3(9), TGFBR1(6), TGFBR2(6), THBS1(10), THBS2(20), THBS3(3), THBS4(12), ZFYVE16(18), ZFYVE9(18)	35156888	658	120	627	184	223	211	117	4	97	6	0.0186	1.000	1.000
303	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(5), ACTA2(7), ACTN2(16), ACTN4(8), DES(7), DMD(84), MYBPC1(16), MYBPC2(13), MYBPC3(13), MYH3(31), MYH6(16), MYH7(35), MYH8(29), MYL1(5), MYL2(2), MYL3(1), MYL9(3), MYOM1(35), NEB(114), TMOD1(4), TNNC2(3), TNNI1(1), TNNI2(4), TNNI3(4), TNNT1(4), TNNT2(8), TNNT3(4), TPM1(3), TPM2(1), TPM3(5), TPM4(4), TTN(491), VIM(8)	52150257	984	119	947	313	275	407	205	3	66	28	0.529	1.000	1.000
304	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(4), AKT3(11), BCAR1(8), CAPN1(5), CAPN10(6), CAPN11(9), CAPN2(11), CAPN3(11), CAPN5(9), CAPN6(13), CAPN7(9), CAPN9(11), CAPNS1(2), CAV1(2), CAV2(1), CDC42(3), CRK(2), CSK(1), DOCK1(21), FYN(5), GIT2(9), GRB2(3), ILK(5), ITGA10(9), ITGA11(7), ITGA2(19), ITGA2B(11), ITGA3(4), ITGA4(10), ITGA5(10), ITGA6(12), ITGA7(14), ITGA8(19), ITGA9(16), ITGAD(11), ITGAE(9), ITGAL(17), ITGAM(21), ITGAV(10), ITGAX(14), ITGB1(8), ITGB2(15), ITGB3(11), ITGB4(8), ITGB5(8), ITGB6(7), ITGB7(4), ITGB8(9), MAP2K1(2), MAP2K2(5), MAP2K3(7), MAP2K6(10), MAPK10(10), MAPK12(2), MAPK4(4), MAPK6(11), MAPK7(14), MYLK2(8), PAK1(3), PAK2(3), PAK3(16), PAK6(4), PDPK1(3), PIK3R2(7), PTK2(12), PXN(6), RAC1(1), RAC2(2), RAP1B(2), RAPGEF1(10), RHO(4), ROCK1(22), ROCK2(17), SDCCAG8(13), SEPP1(1), SHC1(6), SHC3(15), SORBS1(18), SOS1(13), SRC(3), TLN1(23), TNS1(19), VASP(3), VAV2(7), VAV3(13), VCL(11), ZYX(11)	48776737	785	114	763	284	235	289	132	5	117	7	0.594	1.000	1.000
305	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADA(2), ADCY1(21), ADCY2(19), ADCY3(12), ADCY4(12), ADCY5(15), ADCY6(14), ADCY7(9), ADCY8(22), ADK(2), ADSL(8), ADSS(6), AK1(1), AK2(3), AK5(8), ALLC(8), AMPD1(23), AMPD2(6), AMPD3(7), ATIC(7), ATP1B1(6), ATP5A1(8), ATP5B(5), ATP5C1(1), ATP5D(1), ATP5F1(4), ATP5G1(2), ATP5G2(1), ATP5G3(1), ATP5H(1), ATP5I(2), ATP5J(3), CANT1(1), DCK(3), ENPP1(12), ENPP3(17), ENTPD1(4), FHIT(4), GART(9), GDA(4), GMPS(14), GUCY1A2(10), GUCY1A3(11), GUCY1B3(7), GUCY2C(14), GUCY2D(7), GUCY2F(27), GUK1(5), HPRT1(2), IMPDH1(6), ITPA(1), NME1(2), NME2(3), NPR1(11), NPR2(11), NT5C(1), NT5E(6), NT5M(2), NUDT2(2), PAICS(4), PAPSS1(8), PAPSS2(7), PDE1A(14), PDE4A(8), PDE4B(9), PDE4C(2), PDE4D(9), PDE5A(14), PDE6B(5), PDE6C(12), PDE6G(1), PDE7B(7), PDE8A(7), PDE9A(8), PFAS(11), PKLR(6), POLB(4), POLD1(10), POLD2(6), POLE(47), POLG(6), POLL(6), POLQ(29), POLR1B(16), POLR2A(21), POLR2B(21), POLR2C(5), POLR2D(3), POLR2E(1), POLR2F(1), POLR2H(3), POLR2J(1), POLR2K(2), POLRMT(11), PPAT(9), PRPS1(2), PRPS1L1(5), PRPS2(4), PRUNE(5), RRM1(2), RRM2(6)	46086103	794	112	771	247	247	287	145	4	107	4	0.114	1.000	1.000
306	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	91	CD2BP2(2), CDC40(9), CLK2(8), CLK3(6), CLK4(7), COL2A1(16), CPSF1(11), CPSF2(15), CPSF3(8), CPSF4(1), CSTF1(4), CSTF2(13), CSTF2T(5), CSTF3(9), DDIT3(2), DDX1(5), DDX20(4), DHX15(9), DHX16(11), DHX38(10), DHX8(9), DHX9(14), DICER1(36), DNAJC8(1), FUS(2), GIPC1(2), METTL3(6), NCBP1(9), NCBP2(3), NONO(17), NXF1(4), PABPN1(3), PAPOLA(13), PHF5A(1), POLR2A(21), PPM1G(8), PRPF18(5), PRPF3(10), PRPF4(5), PRPF4B(17), PRPF8(26), PSKH1(8), PTBP1(4), PTBP2(10), RBM17(4), RBM5(6), RNGTT(11), RNMT(7), RNPS1(3), SF3A1(4), SF3A2(2), SF3A3(8), SF3B1(16), SF3B2(9), SF3B4(4), SF3B5(2), SNRPA(2), SNRPB(1), SNRPB2(1), SNRPD1(1), SNRPD2(1), SNRPD3(3), SNRPE(1), SNRPN(4), SNURF(1), SPOP(23), SRPK1(10), SRPK2(6), SRRM1(12), SUPT5H(19), U2AF1(4), U2AF2(7), XRN2(19)	38070878	580	110	557	169	193	186	112	2	85	2	0.453	1.000	1.000
307	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(29), ABCA10(26), ABCA12(53), ABCA13(79), ABCA2(10), ABCA3(12), ABCA4(27), ABCA5(30), ABCA6(22), ABCA7(17), ABCA8(28), ABCA9(28), ABCB1(32), ABCB10(10), ABCB11(15), ABCB4(28), ABCB5(31), ABCB6(11), ABCB7(17), ABCB8(7), ABCB9(7), ABCC1(14), ABCC10(10), ABCC11(27), ABCC12(19), ABCC2(30), ABCC3(10), ABCC4(16), ABCC5(14), ABCC6(12), ABCC8(21), ABCC9(29), ABCD1(12), ABCD2(7), ABCD3(7), ABCD4(2), ABCG1(12), ABCG2(16), ABCG4(7), ABCG5(5), ABCG8(7), CFTR(14), TAP1(8), TAP2(1)	42524165	819	108	792	228	223	331	143	3	106	13	0.000224	1.000	1.000
308	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	56	ASH1L(42), ASH2L(12), CARM1(5), CTCFL(13), DOT1L(8), EED(12), EHMT1(23), EHMT2(2), EZH1(10), EZH2(15), FBXO11(8), HCFC1(26), HSF4(3), JMJD4(4), JMJD6(5), KDM6A(14), MEN1(8), NSD1(36), OGT(17), PAXIP1(10), PPP1CA(2), PPP1CB(9), PPP1CC(2), PRDM2(19), PRDM6(6), PRDM7(2), PRDM9(31), PRMT5(10), PRMT6(5), PRMT7(5), PRMT8(7), RBBP5(7), SATB1(18), SETD1A(12), SETD1B(18), SETD2(37), SETD7(7), SETD8(3), SETDB1(15), SETDB2(14), SETMAR(6), SMYD3(6), STK38(9), SUV39H1(7), SUV39H2(5), SUV420H1(15), SUZ12(13), WHSC1(19), WHSC1L1(17)	44102583	599	104	579	183	192	198	110	6	91	2	0.296	1.000	1.000
309	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	90	ACTB(3), BAD(1), CABIN1(19), CALM1(2), CALM2(3), CAMK2B(4), CAMK4(5), CD3E(2), CD3G(3), CD69(2), CDKN1A(1), CNR1(11), CREBBP(32), CSF2(1), CSNK2A1(9), CTLA4(2), EGR2(6), EGR3(7), EP300(32), FCER1A(9), FCGR3A(1), FKBP1B(1), FOS(3), FOSL1(3), GATA3(3), GATA4(3), GSK3A(10), GSK3B(13), HRAS(1), ICOS(3), IFNA1(2), IFNB1(3), IFNG(10), IL10(4), IL1B(2), IL2(2), IL2RA(4), IL3(2), IL4(1), IL6(5), ITK(7), KPNA5(7), MAP2K7(4), MAPK14(4), MAPK8(11), MAPK9(4), MEF2A(3), MEF2B(1), MEF2D(7), MYF5(6), NCK2(8), NFAT5(16), NFATC1(10), NFATC2(13), NFATC3(11), NFATC4(5), NFKB2(9), NFKBIB(1), NFKBIE(6), NPPB(2), NUP214(18), OPRD1(1), P2RX7(1), PAK1(3), PPIA(1), PPP3CB(6), PPP3CC(6), PPP3R1(1), PTPRC(17), RELA(6), RPL13A(1), SLA(4), SP1(7), SP3(10), TGFB1(1), TRAF2(3), TRPV6(10), VAV1(12), VAV2(7), VAV3(13), XPO5(11)	32447336	504	98	489	162	161	160	96	4	82	1	0.184	1.000	1.000
310	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	83	ATF2(8), BRAF(10), CHUK(8), CREB1(5), DAXX(9), ELK1(3), FOS(3), GRB2(3), HRAS(1), IKBKB(13), JUN(1), MAP2K1(2), MAP2K2(5), MAP2K3(7), MAP2K4(9), MAP2K5(3), MAP2K6(10), MAP2K7(4), MAP3K1(30), MAP3K10(7), MAP3K11(5), MAP3K12(6), MAP3K13(13), MAP3K2(12), MAP3K3(8), MAP3K4(21), MAP3K5(25), MAP3K6(7), MAP3K7(9), MAP3K8(10), MAP3K9(6), MAP4K1(12), MAP4K2(5), MAP4K3(16), MAP4K4(10), MAP4K5(7), MAPK1(2), MAPK10(10), MAPK11(3), MAPK12(2), MAPK13(4), MAPK14(4), MAPK3(3), MAPK4(4), MAPK6(11), MAPK7(14), MAPK8(11), MAPK9(4), MAPKAPK2(5), MAPKAPK3(5), MAPKAPK5(5), MAX(9), MEF2A(3), MEF2B(1), MEF2C(10), MEF2D(7), MKNK1(3), MKNK2(2), MYC(8), NFKB1(10), NFKBIA(3), PAK1(3), PAK2(3), RAC1(1), RAF1(9), RELA(6), RIPK1(8), RPS6KA1(1), RPS6KA2(13), RPS6KA3(19), RPS6KA4(2), RPS6KA5(11), RPS6KB1(3), RPS6KB2(4), SHC1(6), SP1(7), STAT1(15), TGFB1(1), TGFB2(5), TGFB3(9), TGFBR1(6), TRAF2(3)	34631614	591	98	575	161	183	211	99	3	92	3	0.0196	1.000	1.000
311	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(17), AMY2A(4), AMY2B(12), ASCC3(31), ATP13A2(5), DDX18(12), DDX19A(4), DDX23(9), DDX4(15), DDX41(3), DDX47(5), DDX50(10), DDX51(8), DDX52(4), DDX54(8), DDX55(6), DDX56(5), DHX58(6), ENPP1(12), ENPP3(17), ENTPD7(8), EP400(42), ERCC2(1), ERCC3(11), G6PC(5), G6PC2(11), GAA(4), GANC(15), GBA(4), GBE1(9), GCK(2), GPI(7), GUSB(5), GYS1(13), GYS2(16), HK1(11), HK2(9), HK3(9), IFIH1(5), LYZL1(4), MGAM(38), MOV10L1(19), NUDT5(2), NUDT8(1), PGM1(6), PGM3(3), PYGB(11), PYGL(8), PYGM(10), RAD54B(14), RAD54L(6), RUVBL2(4), SETX(33), SI(65), SKIV2L2(17), SMARCA2(24), SMARCA5(19), UGDH(2), UGP2(6), UGT1A1(11), UGT1A10(7), UGT1A3(2), UGT1A4(3), UGT1A5(7), UGT1A6(5), UGT1A7(7), UGT1A9(3), UGT2A1(9), UGT2A3(5), UGT2B10(18), UGT2B11(8), UGT2B15(9), UGT2B17(7), UGT2B28(15), UGT2B4(11), UGT2B7(5), UXS1(5)	45031394	809	97	782	198	214	282	191	9	107	6	0.000325	1.000	1.000
312	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	66	A2M(18), BDKRB1(3), BDKRB2(8), C1QA(4), C1QB(3), C1QC(4), C1R(11), C1S(8), C2(2), C3(22), C3AR1(9), C4BPA(6), C4BPB(6), C5(18), C5AR1(4), C6(16), C7(20), C8A(9), C8B(5), C8G(2), C9(19), CD46(3), CD55(6), CD59(4), CFB(3), CFH(22), CFI(8), CPB2(7), CR1(22), CR2(22), F10(12), F11(15), F12(2), F13A1(8), F13B(15), F2(8), F2R(6), F3(5), F5(47), F7(2), F8(45), F9(14), FGA(26), FGB(7), FGG(9), KLKB1(10), KNG1(11), MASP1(13), MASP2(7), MBL2(4), PLAT(6), PLAUR(7), PLG(14), PROC(4), PROS1(21), SERPINA1(4), SERPINA5(5), SERPINC1(10), SERPIND1(7), SERPINE1(5), SERPINF2(4), SERPING1(7), TFPI(8), THBD(1), VWF(25)	32691403	688	97	660	202	172	295	118	4	93	6	0.0489	1.000	1.000
313	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	106	A4GNT(7), ALG1(2), ALG10(6), ALG10B(6), ALG11(6), ALG12(6), ALG13(24), ALG14(2), ALG2(2), ALG6(5), ALG8(11), ALG9(2), B3GNT1(5), B3GNT2(1), B3GNT7(3), B4GALT1(2), B4GALT2(5), B4GALT3(10), B4GALT4(5), B4GALT5(2), B4GALT7(4), C1GALT1(2), C1GALT1C1(6), CHPF(5), CHST1(8), CHST11(8), CHST12(3), CHST14(3), CHST2(2), CHST3(4), CHST4(4), CHST6(6), CHST7(4), CHSY1(8), DAD1(2), DDOST(3), DPAGT1(3), EXT1(12), EXT2(6), EXTL1(9), EXTL2(8), EXTL3(10), FUT11(3), FUT8(10), GALNT1(10), GALNT10(8), GALNT11(12), GALNT12(6), GALNT13(18), GALNT14(6), GALNT2(10), GALNT3(8), GALNT4(8), GALNT5(5), GALNT6(1), GALNT7(12), GALNT8(11), GALNT9(8), GALNTL5(11), GANAB(10), GCNT1(5), GCNT3(5), GCNT4(1), HS2ST1(7), HS3ST1(5), HS3ST2(5), HS3ST3A1(2), HS3ST3B1(5), HS3ST5(9), HS6ST1(2), HS6ST2(9), HS6ST3(3), MAN1A1(13), MAN1A2(7), MAN1B1(5), MAN1C1(6), MAN2A1(20), MGAT1(4), MGAT2(4), MGAT3(4), MGAT4A(5), MGAT4B(6), MGAT5(11), MGAT5B(10), NDST1(14), NDST2(9), NDST3(14), NDST4(15), OGT(17), RPN1(3), RPN2(5), ST3GAL1(2), ST3GAL2(6), ST3GAL3(6), ST3GAL4(3), ST6GAL1(7), ST6GALNAC1(4), STT3B(5), UST(3), WBSCR17(15), XYLT1(16), XYLT2(4)	38860123	690	96	671	223	225	238	141	3	80	3	0.193	1.000	1.000
314	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	85	AICDA(5), AK3(2), CAD(25), CANT1(1), CDA(2), CTPS2(7), DCK(3), DCTD(5), DHODH(3), DPYD(20), DPYS(6), DTYMK(2), ENTPD1(4), ENTPD3(5), ENTPD4(2), ENTPD5(2), ENTPD6(11), ENTPD8(5), ITPA(1), NME1(2), NME2(3), NME4(1), NME6(2), NME7(4), NT5C(1), NT5C1A(2), NT5C1B(8), NT5C2(6), NT5E(6), NT5M(2), NUDT2(2), PNPT1(7), POLA1(29), POLA2(3), POLD1(10), POLD2(6), POLD3(6), POLD4(1), POLE(47), POLE2(4), POLE3(3), POLE4(1), POLR1A(15), POLR1B(16), POLR1C(2), POLR1D(3), POLR2A(21), POLR2B(21), POLR2C(5), POLR2D(3), POLR2E(1), POLR2F(1), POLR2H(3), POLR2J(1), POLR2K(2), POLR3A(7), POLR3B(14), POLR3G(3), POLR3GL(2), POLR3H(4), PRIM1(3), RFC5(8), RRM1(2), RRM2(6), RRM2B(5), TK1(3), TK2(6), TXNRD1(10), TXNRD2(5), UCK1(5), UCK2(5), UMPS(6), UPB1(10), UPP1(4), UPP2(4), UPRT(8)	29373971	481	94	462	156	144	168	91	5	72	1	0.303	1.000	1.000
315	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	51	ACTG1(6), APAF1(17), ARHGDIB(3), BAG4(5), BID(2), BIRC2(10), BIRC3(5), CASP2(6), CASP3(4), CASP6(7), CASP7(1), CASP8(21), CASP9(3), CFLAR(2), CHUK(8), CRADD(3), CYCS(2), DAXX(9), DFFB(4), FADD(1), GSN(4), LMNA(7), LMNB1(5), LMNB2(4), MAP2K7(4), MAP3K1(30), MAP3K5(25), MAPK8(11), MDM2(5), NFKB1(10), NFKBIA(3), NUMA1(20), PAK2(3), PRKCD(5), PRKDC(54), PSEN1(5), PSEN2(8), PTK2(12), RASA1(29), RB1(26), RELA(6), RIPK1(8), SPTAN1(31), TNFRSF1A(4), TNFRSF1B(2), TRAF1(5), TRAF2(3)	25165677	448	93	435	126	119	155	78	5	86	5	0.165	1.000	1.000
316	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	83	ANPEP(15), CD14(2), CD19(4), CD1A(5), CD1B(1), CD1C(15), CD1D(5), CD1E(6), CD2(4), CD22(14), CD33(6), CD34(1), CD36(8), CD37(2), CD38(6), CD3D(6), CD3E(2), CD3G(3), CD4(6), CD44(5), CD5(10), CD55(6), CD59(4), CD7(3), CD8A(2), CD8B(1), CD9(2), CR1(22), CR2(22), CSF1(6), CSF1R(8), CSF2(1), CSF2RA(10), CSF3(1), CSF3R(7), DNTT(3), EPO(3), EPOR(4), FCER2(1), FCGR1A(6), FLT3(16), FLT3LG(2), GP5(3), GP9(1), HLA-DRA(1), HLA-DRB5(1), IL11(2), IL11RA(5), IL1B(2), IL1R1(5), IL1R2(5), IL2RA(4), IL3(2), IL3RA(9), IL4(1), IL4R(6), IL5(2), IL5RA(9), IL6(5), IL6R(7), IL7(1), IL7R(12), IL9R(3), ITGA1(17), ITGA2(19), ITGA2B(11), ITGA3(4), ITGA4(10), ITGA5(10), ITGA6(12), ITGAM(21), ITGB3(11), KIT(23), KITLG(3), MME(11), MS4A1(7), TFRC(4), THPO(5), TPO(14)	29769275	524	91	514	182	123	207	99	3	89	3	0.473	1.000	1.000
317	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	68	ACACB(29), ACSL1(13), ACSL3(7), ACSL4(21), ACSL5(8), ACSL6(12), ADIPOQ(2), ADIPOR1(3), ADIPOR2(7), AGRP(2), AKT1(4), AKT2(6), AKT3(11), CAMKK1(11), CAMKK2(6), CD36(8), CHUK(8), CPT1A(9), CPT1B(6), CPT1C(15), CPT2(4), G6PC(5), G6PC2(11), IKBKB(13), IKBKG(3), IRS1(13), IRS4(20), JAK1(20), JAK2(17), JAK3(10), LEP(2), LEPR(12), MAPK10(10), MAPK8(11), MAPK9(4), NFKB1(10), NFKB2(9), NFKBIA(3), NFKBIB(1), NFKBIE(6), NPY(2), PCK1(9), PCK2(7), POMC(4), PPARA(2), PPARGC1A(9), PRKAA1(8), PRKAA2(11), PRKAB1(6), PRKAB2(1), PRKAG1(3), PRKAG2(4), PRKAG3(6), PRKCQ(9), PTPN11(8), RELA(6), RXRA(3), RXRG(9), SLC2A1(2), SLC2A4(9), STAT3(11), STK11(2), TNFRSF1A(4), TNFRSF1B(2), TRAF2(3), TYK2(10)	28958077	522	90	511	183	147	191	94	5	81	4	0.454	1.000	1.000
318	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(12), CD28(3), CD3D(6), CSK(1), CTLA4(2), DAG1(6), DTYMK(2), EPHB2(11), FBXW7(44), GRB2(3), ITK(7), ITPKA(1), ITPKB(11), LCK(4), LCP2(5), MAPK1(2), NCK1(4), NFAT5(16), NFKB1(10), NFKB2(9), NFKBIA(3), NFKBIB(1), NFKBIE(6), NFKBIL1(1), PAK1(3), PAK2(3), PAK3(16), PAK6(4), PAK7(9), PLCG1(12), PTPRC(17), RAF1(9), RASGRP1(8), RASGRP2(4), RASGRP3(11), RASGRP4(6), SOS1(13), SOS2(17), VAV1(12), ZAP70(8)	19923014	322	88	299	110	97	113	55	4	51	2	0.622	1.000	1.000
319	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	ADAM17(11), CREBBP(32), CTBP1(1), CTBP2(3), DLL1(6), DLL3(6), DLL4(6), DTX1(7), DTX2(4), DTX3(5), DTX3L(7), DTX4(4), DVL1(3), DVL2(10), DVL3(9), EP300(32), HDAC1(5), HDAC2(3), HES1(1), JAG1(22), JAG2(2), LFNG(2), MAML1(6), MAML2(9), MAML3(13), MFNG(2), NCOR2(24), NCSTN(9), NOTCH1(10), NOTCH2(18), NOTCH3(29), NOTCH4(9), NUMB(9), NUMBL(4), PSEN1(5), PSEN2(8), RBPJ(5), RBPJL(8), SNW1(6)	22970247	355	85	346	122	129	105	57	6	56	2	0.302	1.000	1.000
320	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT1(4), AKT2(6), AKT3(11), ASAH1(6), BRAF(10), DAG1(6), DRD2(8), EGFR(12), EPHB2(11), GRB2(3), ITPKA(1), ITPKB(11), ITPR1(34), ITPR2(35), ITPR3(22), KCNJ3(9), KCNJ5(7), KCNJ9(4), MAPK1(2), PI3(2), PIK3CB(17), PITX2(8), PLCB1(5), PLCB2(8), PLCB3(11), PLCB4(19), RAF1(9), RGS20(2), SHC1(6), SOS1(13), SOS2(17), SRC(3), STAT3(11), TERF2IP(2)	21223221	335	84	324	136	100	126	56	5	46	2	0.919	1.000	1.000
321	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	AKT1(4), APC(56), ASAH1(6), CAMP(1), DAG1(6), DLG4(10), EPHB2(11), GNAI1(5), GNAQ(3), ITPR1(34), ITPR2(35), ITPR3(22), KCNJ3(9), KCNJ5(7), KCNJ9(4), MAPK1(2), PITX2(8), PTX3(2), RAC1(1), RHO(4), RYR1(73)	16749934	303	84	292	127	82	140	34	3	40	4	0.875	1.000	1.000
322	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP2(6), BMP4(10), BMP5(14), BMP6(5), BMP7(12), BMP8A(3), BMP8B(1), BTRC(14), CSNK1A1(3), CSNK1A1L(4), CSNK1D(3), CSNK1E(3), CSNK1G1(6), CSNK1G2(2), CSNK1G3(8), DHH(2), FBXW11(5), GLI1(13), GLI2(10), GLI3(28), GSK3B(13), HHIP(12), IHH(3), LRP2(91), PRKACA(6), PRKACB(3), PRKACG(9), PRKX(2), PTCH1(22), PTCH2(11), RAB23(4), SHH(4), SMO(9), STK36(5), SUFU(3), WNT1(1), WNT10A(2), WNT10B(1), WNT11(5), WNT16(7), WNT2(3), WNT2B(6), WNT3(3), WNT3A(1), WNT4(1), WNT5A(6), WNT5B(3), WNT6(1), WNT7A(3), WNT7B(2), WNT8A(2), WNT8B(5), WNT9A(4), WNT9B(2), ZIC2(1)	20670823	408	81	399	141	149	156	55	4	42	2	0.280	1.000	1.000
323	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	66	ADAM10(4), ADAM17(11), ATP6AP1(7), ATP6V0A1(8), ATP6V0A2(12), ATP6V0A4(11), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(2), ATP6V0D2(11), ATP6V1A(7), ATP6V1B1(12), ATP6V1B2(7), ATP6V1C1(4), ATP6V1C2(12), ATP6V1D(3), ATP6V1E1(6), ATP6V1E2(4), ATP6V1F(2), ATP6V1G1(2), ATP6V1G2(2), ATP6V1G3(2), ATP6V1H(7), CASP3(4), CCL5(2), CDC42(3), CHUK(8), CSK(1), CXCL1(3), EGFR(12), F11R(1), GIT1(9), HBEGF(2), IGSF5(5), IKBKB(13), IKBKG(3), JAM2(9), JAM3(2), JUN(1), LYN(9), MAP2K4(9), MAPK10(10), MAPK11(3), MAPK12(2), MAPK13(4), MAPK14(4), MAPK8(11), MAPK9(4), MET(17), NFKB1(10), NFKB2(9), NFKBIA(3), NOD1(9), PAK1(3), PLCG1(12), PLCG2(27), PTPN11(8), PTPRZ1(46), RAC1(1), RELA(6), SRC(3), TCIRG1(6), TJP1(24)	25714605	457	81	451	144	115	190	80	1	69	2	0.301	1.000	1.000
324	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(17), CARM1(5), CCND1(14), CREBBP(32), EP300(32), ERCC3(11), ESR1(11), GRIP1(12), GTF2A1(3), GTF2E1(3), GTF2F1(7), HDAC1(5), HDAC2(3), HDAC3(12), HDAC4(14), HDAC5(12), HDAC6(24), MEF2C(10), NCOR2(24), NR0B1(8), NRIP1(17), PELP1(9), POLR2A(21), TBP(3)	16878927	309	80	295	82	112	89	53	1	53	1	0.00855	1.000	1.000
325	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	48	ADORA3(4), ALG6(5), CCKBR(3), CCR2(5), CCR3(4), CCR5(6), CELSR1(24), CELSR2(22), CELSR3(26), CHRM2(10), CHRM3(8), CIDEB(2), CXCR3(5), EDNRA(5), EMR2(4), EMR3(3), F2R(6), FSHR(15), GHRHR(2), GNRHR(4), GPR116(21), GPR132(6), GPR133(15), GPR135(4), GPR143(4), GPR17(6), GPR18(3), GPR55(3), GPR56(3), GPR61(4), GPR84(3), GRM1(26), GRPR(4), HRH4(5), LGR6(12), LPHN2(22), LPHN3(21), LTB4R2(4), NTSR1(5), P2RY11(7), P2RY13(2), PTGFR(10), SMO(9), SSTR2(3), TAAR5(5), TSHR(8), VN1R1(5)	22229698	383	80	381	152	110	161	60	3	47	2	0.592	1.000	1.000
326	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	66	ACAA1(5), ACADL(8), ACADM(9), ACOX1(7), ACOX2(9), ACOX3(8), ACSL1(13), ACSL3(7), ACSL4(21), ACSL5(8), ACSL6(12), ADIPOQ(2), APOA1(3), APOA2(2), APOA5(2), APOC3(1), AQP7(3), CD36(8), CPT1A(9), CPT1B(6), CPT1C(15), CPT2(4), CYP27A1(9), CYP4A11(7), CYP4A22(7), CYP7A1(11), CYP8B1(4), DBI(1), EHHADH(10), FABP1(4), FABP2(2), FABP3(1), FABP4(2), FABP5(3), FABP6(3), FABP7(1), FADS2(2), GK(17), GK2(20), HMGCS2(9), ILK(5), LPL(16), ME1(12), MMP1(4), NR1H3(4), OLR1(2), PCK1(9), PCK2(7), PDPK1(3), PLTP(7), PPARA(2), PPARD(3), PPARG(6), RXRA(3), RXRG(9), SCD(6), SCP2(10), SLC27A1(10), SLC27A2(3), SLC27A4(5), SLC27A5(3), SLC27A6(9), SORBS1(18), UBC(8), UCP1(2)	23302521	441	80	432	130	130	160	86	1	64	0	0.0629	1.000	1.000
327	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	AK3(2), CAD(25), CANT1(1), CDA(2), CTPS2(7), DCK(3), DCTD(5), DHODH(3), DPYD(20), DPYS(6), DTYMK(2), ENTPD1(4), ITPA(1), NME1(2), NME2(3), NT5C(1), NT5E(6), NT5M(2), NUDT2(2), POLB(4), POLD1(10), POLD2(6), POLE(47), POLG(6), POLL(6), POLQ(29), POLR1B(16), POLR2A(21), POLR2B(21), POLR2C(5), POLR2D(3), POLR2E(1), POLR2F(1), POLR2H(3), POLR2J(1), POLR2K(2), POLRMT(11), RRM1(2), RRM2(6), TK1(3), TK2(6), TXNRD1(10), UCK1(5), UCK2(5), UMPS(6), UNG(3), UPB1(10), UPP1(4)	20573408	350	80	333	109	105	137	62	1	44	1	0.207	1.000	1.000
328	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(6), AASDHPPT(9), AASS(12), ACAT1(6), ACAT2(4), AKR1B10(4), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(4), ALDH3A2(3), ALDH7A1(1), ALDH9A1(2), BBOX1(1), DLST(8), DOT1L(8), ECHS1(3), EHHADH(10), EHMT1(23), EHMT2(2), GCDH(4), HADH(1), HADHA(5), HSD17B10(4), HSD17B4(12), HSD3B7(5), NSD1(36), OGDH(13), OGDHL(19), PIPOX(4), PLOD1(4), PLOD2(11), PLOD3(6), RDH11(1), RDH12(5), RDH13(4), RDH14(2), SETD1A(12), SETD7(7), SETDB1(15), SHMT1(5), SHMT2(5), SPCS3(2), SUV39H1(7), SUV39H2(5), TMLHE(6)	20158536	323	79	312	114	115	107	63	9	28	1	0.507	1.000	1.000
329	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	65	AGTR1(4), AGTR2(11), ATP8A1(16), AVPR1A(7), AVPR1B(3), AVPR2(4), BDKRB1(3), BDKRB2(8), BRS3(17), C3AR1(9), CCKAR(9), CCKBR(3), CCR1(4), CCR2(5), CCR3(4), CCR4(5), CCR5(6), CCR6(5), CCR7(6), CCR8(6), CX3CR1(6), CXCR3(5), CXCR4(1), CXCR6(1), EDNRA(5), EDNRB(4), FPR1(2), FSHR(15), GALR1(3), GALR3(2), GALT(3), GHSR(8), GNB2L1(1), GNRHR(4), GRPR(4), LHCGR(17), MC1R(3), MC2R(4), MC3R(5), MC4R(5), MC5R(14), NMBR(4), NPY1R(9), NPY2R(5), NPY5R(13), NTSR1(5), NTSR2(1), OPRD1(1), OPRK1(10), OPRL1(3), OPRM1(11), OXTR(4), SSTR1(9), SSTR2(3), SSTR3(3), SSTR4(10), TACR1(7), TACR2(3), TACR3(9), TRHR(3), TSHR(8)	18351949	368	79	356	139	109	158	49	6	44	2	0.195	1.000	1.000
330	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(22), ATP4A(9), ATP4B(4), ATP5A1(8), ATP5B(5), ATP5C1(1), ATP5D(1), ATP5E(2), ATP5F1(4), ATP5G1(2), ATP5G2(1), ATP5G3(1), ATP5H(1), ATP5I(2), ATP5J(3), ATP5L(1), ATP5O(1), ATP6AP1(7), ATP6V0A1(8), ATP6V0A2(12), ATP6V0A4(11), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(2), ATP6V0D2(11), ATP6V1A(7), ATP6V1B1(12), ATP6V1B2(7), ATP6V1C1(4), ATP6V1C2(12), ATP6V1D(3), ATP6V1E1(6), ATP6V1E2(4), ATP6V1F(2), ATP6V1G1(2), ATP6V1G2(2), ATP6V1G3(2), ATP6V1H(7), COX10(3), COX15(3), COX17(1), COX4I1(3), COX5A(1), COX5B(1), COX6A1(3), COX6A2(1), COX6B1(1), COX6C(3), COX7A1(3), COX7B(4), COX7B2(3), COX7C(2), COX8A(1), COX8C(1), CYC1(3), LHPP(2), NDUFA1(1), NDUFA10(6), NDUFA13(1), NDUFA2(3), NDUFA3(1), NDUFA4(1), NDUFA4L2(1), NDUFA5(1), NDUFA6(2), NDUFA8(5), NDUFA9(5), NDUFAB1(2), NDUFB1(1), NDUFB10(1), NDUFB11(3), NDUFB7(3), NDUFB8(2), NDUFC1(1), NDUFC2(1), NDUFS1(13), NDUFS2(7), NDUFS4(3), NDUFS5(1), NDUFS7(1), NDUFS8(3), NDUFV1(3), NDUFV2(2), PPA1(4), PPA2(5), SDHA(14), SDHB(2), SDHC(2), SDHD(3), TCIRG1(6), UQCRB(4), UQCRC1(2), UQCRC2(7), UQCRFS1(3), UQCRH(1), UQCRQ(2)	20433737	360	78	356	97	114	128	53	2	61	2	0.0141	1.000	1.000
331	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AADAT(6), AANAT(2), ACAT1(6), ACAT2(4), ACMSD(8), AFMID(6), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(4), ALDH3A2(3), ALDH7A1(1), ALDH9A1(2), AOC2(7), AOC3(10), AOX1(18), ASMT(5), CARM1(5), CAT(4), CYP1A1(11), CYP1A2(11), CYP1B1(2), DDC(8), ECHS1(3), EHHADH(10), GCDH(4), HAAO(2), HADH(1), HADHA(5), HEMK1(2), HSD17B10(4), HSD17B4(12), INMT(2), KMO(8), KYNU(7), LCMT1(2), LCMT2(9), LNX1(8), MAOA(12), MAOB(7), METTL2B(4), METTL6(4), NFX1(15), OGDH(13), OGDHL(19), PRMT2(1), PRMT3(8), PRMT5(10), PRMT6(5), PRMT7(5), PRMT8(7), TDO2(3), TPH1(9), TPH2(4), WARS(6), WARS2(3), WBSCR22(2)	21980296	356	78	345	109	106	135	70	6	37	2	0.122	1.000	1.000
332	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(17), AMY2A(4), AMY2B(12), ENPP1(12), ENPP3(17), G6PC(5), GAA(4), GANAB(10), GBE1(9), GCK(2), GPI(7), GUSB(5), GYS1(13), GYS2(16), HK1(11), HK2(9), HK3(9), MGAM(38), PGM1(6), PGM3(3), PYGB(11), PYGL(8), PYGM(10), RNPC3(6), SI(65), UCHL1(4), UGDH(2), UGT1A1(11), UGT1A10(7), UGT1A3(2), UGT1A4(3), UGT1A5(7), UGT1A6(5), UGT1A7(7), UGT1A9(3), UGT2B15(9), UGT2B4(11), UXS1(5)	21023868	385	76	380	96	89	142	90	5	59	0	0.0139	1.000	1.000
333	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	54	ADH1A(2), ADH1B(5), ADH4(4), ADH6(9), ADH7(4), ADHFE1(5), ALDH1A3(8), ALDH3A1(4), ALDH3B2(7), AOC2(7), AOC3(10), AOX1(18), CARM1(5), COMT(3), DBH(9), DCT(11), DDC(8), ECH1(2), ESCO1(16), ESCO2(8), FAH(6), GOT1(9), GOT2(3), GSTZ1(5), HEMK1(2), HGD(4), HPD(2), LCMT1(2), LCMT2(9), MAOA(12), MAOB(7), METTL2B(4), METTL6(4), NAT6(1), PNMT(2), PNPLA3(7), PRMT2(1), PRMT3(8), PRMT5(10), PRMT6(5), PRMT7(5), PRMT8(7), SH3GLB1(7), TAT(7), TH(3), TPO(14), TYR(12), TYRP1(7), WBSCR22(2)	21082149	312	74	307	94	90	113	59	4	46	0	0.120	1.000	1.000
334	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(2), ADH1B(5), ADH4(4), ADH6(9), ADH7(4), ADHFE1(5), AGK(10), AGPAT2(2), AGPAT3(4), AGPAT4(5), AGPAT6(6), AKR1A1(1), AKR1B1(1), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(4), ALDH3A2(3), ALDH7A1(1), ALDH9A1(2), CEL(5), DAK(4), DGAT1(3), DGAT2(6), DGKA(9), DGKB(23), DGKD(18), DGKE(5), DGKG(11), DGKH(10), DGKI(18), DGKQ(2), DGKZ(10), GK(17), GK2(20), GLA(9), GLB1(6), GPAM(9), LCT(32), LIPA(8), LIPC(8), LIPF(6), LIPG(7), LPL(16), MGLL(2), PNLIP(6), PNLIPRP1(5), PNPLA3(7), PPAP2A(5), PPAP2B(3), PPAP2C(1)	21221405	376	74	369	130	116	138	77	3	40	2	0.346	1.000	1.000
335	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	34	ACTG1(6), ACTR2(6), ACTR3(1), AKT1(4), ANGPTL2(6), CDC42(3), CFL1(1), CFL2(8), FLNA(38), FLNC(37), FSCN1(5), FSCN3(5), GDI1(4), GDI2(1), LIMK1(8), MYH2(41), MYLK(14), MYLK2(8), PAK1(3), PAK2(3), PAK3(16), PAK6(4), PAK7(9), PFN1(1), PFN2(2), RHO(4), ROCK1(22), ROCK2(17), RPS4X(1), VASP(3), WASF1(3), WASL(8)	16540338	292	74	289	89	88	117	42	3	37	5	0.0507	1.000	1.000
336	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(8), AGTR2(11), CALM1(2), CALM2(3), CAMK2A(9), CAMK2B(4), CAMK2D(5), CAMK2G(5), CDK5(2), F2(8), FYN(5), GNA11(2), GNAI1(5), GNB1(2), GNGT1(1), GRB2(3), HRAS(1), JAK2(17), MAP2K1(2), MAP2K2(5), MAPK1(2), MAPK14(4), MAPK3(3), MAPK8(11), MAPT(9), MYLK(14), PLCG1(12), PRKCA(11), PTK2B(15), RAF1(9), SHC1(6), SOS1(13), STAT1(15), STAT3(11), STAT5A(5), SYT1(4)	15149973	244	73	235	84	82	84	43	1	31	3	0.433	1.000	1.000
337	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	37	ATF2(8), CDC42(3), CREB1(5), DAXX(9), DDIT3(2), ELK1(3), GRB2(3), HMGN1(2), HRAS(1), HSPB2(1), MAP2K4(9), MAP2K6(10), MAP3K1(30), MAP3K5(25), MAP3K7(9), MAP3K9(6), MAPK14(4), MAPKAPK2(5), MAPKAPK5(5), MAX(9), MEF2A(3), MEF2B(1), MEF2C(10), MEF2D(7), MKNK1(3), MYC(8), PLA2G4A(13), RAC1(1), RIPK1(8), RPS6KA5(11), SHC1(6), STAT1(15), TGFB1(1), TGFB2(5), TGFB3(9), TGFBR1(6), TRAF2(3)	13320121	259	73	250	65	71	96	48	1	42	1	0.0565	1.000	1.000
338	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(3), CDC7(11), CDK2(2), CDT1(1), DIAPH2(31), GMNN(2), MCM10(8), MCM2(7), MCM3(9), MCM4(11), MCM5(8), MCM6(6), MCM7(6), NACA(20), PCNA(3), POLA2(3), POLD1(10), POLD2(6), POLD3(6), POLD4(1), POLE(47), POLE2(4), PRIM1(3), RFC1(21), RFC2(4), RFC3(4), RFC4(5), RFC5(8), RPA1(6), RPA2(3), RPA3(3), RPA4(4), RPS27A(4), UBA52(1), UBB(2), UBC(8)	18401804	281	72	260	79	70	133	35	3	38	2	0.216	1.000	1.000
339	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(22), ATP4B(4), ATP5E(2), ATP5O(1), ATP6AP1(7), ATP6V0A1(8), ATP6V0A4(11), ATP6V0B(2), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(7), ATP6V1B1(12), ATP6V1B2(7), ATP6V1C1(4), ATP6V1C2(12), ATP6V1D(3), ATP6V1E1(6), ATP6V1F(2), ATP6V1G1(2), ATP6V1G2(2), ATP6V1G3(2), ATP6V1H(7), ATP7A(29), ATP7B(14), COX10(3), COX4I1(3), COX5A(1), COX5B(1), COX6A1(3), COX6A2(1), COX6B1(1), COX6C(3), COX7A1(3), COX7B(4), COX7C(2), COX8A(1), NDUFA1(1), NDUFA10(6), NDUFA4(1), NDUFA5(1), NDUFA8(5), NDUFB7(3), NDUFS1(13), NDUFS2(7), NDUFV1(3), NDUFV2(2), PPA2(5), SDHA(14), SDHB(2), SHMT1(5), UQCRB(4), UQCRC1(2), UQCRFS1(3), UQCRH(1)	14142139	273	72	269	70	76	103	38	2	52	2	0.0146	1.000	1.000
340	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	35	AKT1(4), AKT2(6), AKT3(11), ARHGEF11(20), CDC42(3), DLG4(10), GNA13(7), IKBKG(3), LPA(14), MAP2K4(9), MAP3K1(30), MAP3K5(25), MAPK8(11), NFKB1(10), NFKB2(9), NFKBIA(3), NFKBIB(1), NFKBIE(6), NFKBIL1(1), PDK1(2), PHKA2(21), PI3(2), PIK3CB(17), PLD1(13), PLD2(10), PLD3(5), PTK2(12), RDX(17), ROCK1(22), ROCK2(17), SERPINA4(4), SRF(3)	17689412	328	72	316	83	100	106	54	0	64	4	0.0353	1.000	1.000
341	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	27	ADRBK1(8), AKT1(4), AKT2(6), AKT3(11), DAG1(6), GNAQ(3), IKBKG(3), ITPKA(1), ITPKB(11), ITPR1(34), ITPR2(35), ITPR3(22), NFKB1(10), NFKB2(9), NFKBIA(3), NFKBIB(1), NFKBIE(6), NFKBIL1(1), PDK1(2), PHKA2(21), PIK3CB(17), PITX2(8), PLD1(13), PLD2(10), PLD3(5), VN1R1(5)	16052704	255	72	247	94	81	98	32	1	42	1	0.585	1.000	1.000
342	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ADCY4(12), ADCY6(14), ADCY8(22), CACNA1A(19), CACNA1B(31), GNAS(24), GNAT3(8), GNB1(2), GNB3(2), GNG13(2), GNG3(2), GRM4(11), ITPR3(22), KCNB1(13), PDE1A(14), PLCB2(8), PRKACA(6), PRKACB(3), PRKACG(9), PRKX(2), SCNN1A(3), SCNN1B(4), SCNN1G(9), TAS1R1(10), TAS1R2(11), TAS1R3(4), TAS2R1(4), TAS2R10(9), TAS2R13(3), TAS2R14(6), TAS2R16(4), TAS2R3(4), TAS2R38(5), TAS2R39(9), TAS2R4(3), TAS2R40(5), TAS2R41(4), TAS2R42(4), TAS2R43(1), TAS2R46(2), TAS2R5(4), TAS2R50(4), TAS2R60(6), TAS2R7(3), TAS2R8(6), TAS2R9(3), TRPM5(8)	20433711	364	71	357	143	120	134	67	2	40	1	0.702	1.000	1.000
343	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	42	CHUK(8), DAXX(9), EGF(19), EGFR(12), ETS1(6), ETS2(6), FOS(3), HOXA7(8), HRAS(1), IKBKB(13), JUN(1), MAP2K1(2), MAP2K3(7), MAP2K4(9), MAP2K6(10), MAP2K7(4), MAP3K1(30), MAP3K5(25), MAPK1(2), MAPK13(4), MAPK14(4), MAPK3(3), MAPK8(11), NFKB1(10), NFKBIA(3), PPP2CA(6), PRKCA(11), PRKCD(5), PRKCE(10), PRKCG(8), PRKCH(10), PRKCQ(9), RAF1(9), RELA(6), RIPK1(8), SP1(7), TNFRSF1A(4), TNFRSF1B(2), TRAF2(3)	17531738	308	71	300	91	85	108	56	1	57	1	0.115	1.000	1.000
344	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(5), AKT1(4), BDKRB2(8), CALM1(2), CALM2(3), CAV1(2), CHRM1(6), CHRNA1(7), FLT1(20), FLT4(8), KDR(26), NOS3(11), PDE2A(14), PDE3A(19), PDE3B(15), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PRKG1(11), PRKG2(11), RYR2(109), SLC7A1(8), SYT1(4), TNNI1(1)	14841596	321	71	313	112	92	115	61	3	45	5	0.435	1.000	1.000
345	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(2), ADH1B(5), ADH4(4), ADH6(9), ADH7(4), ADHFE1(5), AGPAT2(2), AGPAT3(4), AGPAT4(5), AKR1A1(1), AKR1B1(1), ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(4), ALDH3A2(3), ALDH9A1(2), CEL(5), DGAT1(3), DGKA(9), DGKB(23), DGKD(18), DGKE(5), DGKG(11), DGKH(10), DGKQ(2), DGKZ(10), GK(17), GLA(9), GLB1(6), LCT(32), LIPC(8), LIPF(6), LIPG(7), LPL(16), PNLIP(6), PNLIPRP1(5), PPAP2A(5), PPAP2B(3), PPAP2C(1)	17350704	306	70	303	100	92	110	67	3	33	1	0.191	1.000	1.000
346	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	58	A4GALT(2), B3GALNT1(6), B3GALT1(12), B3GALT2(8), B3GALT4(3), B3GALT5(4), B3GNT1(5), B3GNT2(1), B3GNT3(5), B3GNT4(4), B3GNT5(6), B4GALNT1(6), B4GALT1(2), B4GALT2(5), B4GALT3(10), B4GALT4(5), B4GALT6(6), FUT1(4), FUT2(1), FUT3(8), FUT5(1), FUT6(10), FUT7(2), FUT9(9), GBGT1(6), GCNT2(4), PIGA(8), PIGB(11), PIGC(3), PIGF(2), PIGG(6), PIGH(5), PIGK(9), PIGL(1), PIGM(1), PIGN(13), PIGO(9), PIGP(3), PIGQ(5), PIGS(1), PIGT(8), PIGU(2), PIGV(7), PIGX(2), PIGZ(5), ST3GAL1(2), ST3GAL2(6), ST3GAL3(6), ST3GAL4(3), ST3GAL5(4), ST3GAL6(6), ST6GALNAC3(8), ST6GALNAC4(4), ST6GALNAC5(2), ST6GALNAC6(6), ST8SIA1(2), ST8SIA5(8), UGCG(4)	16968686	297	70	290	74	101	107	51	2	36	0	0.00245	1.000	1.000
347	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	23	POLA1(29), POLA2(3), POLB(4), POLD1(10), POLD2(6), POLD3(6), POLD4(1), POLE(47), POLE2(4), POLE3(3), POLE4(1), POLG(6), POLG2(3), POLH(12), POLI(6), POLK(11), POLL(6), POLM(6), POLQ(29), PRIM1(3), REV1(14), REV3L(35), RFC5(8)	14833216	253	70	234	61	58	106	43	3	42	1	0.0990	1.000	1.000
348	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(6), ACTR3(1), ARHGAP1(2), ARHGAP4(10), ARHGAP5(21), ARHGAP6(18), ARHGEF1(12), ARHGEF11(20), ARHGEF5(13), ARPC1A(6), ARPC1B(5), ARPC2(1), ARPC3(1), ARPC4(1), BAIAP2(5), CFL1(1), DIAPH1(12), GSN(4), LIMK1(8), MYL2(2), MYLK(14), OPHN1(19), PFN1(1), PIP5K1A(8), PIP5K1B(5), PPP1R12B(19), ROCK1(22), SRC(3), TLN1(23), VCL(11)	16688465	274	70	267	83	97	95	46	0	33	3	0.225	1.000	1.000
349	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(7), AARS2(6), CARS(8), CARS2(5), DARS(7), DARS2(10), EARS2(5), EPRS(15), FARS2(2), FARSA(6), FARSB(7), GARS(8), HARS(5), HARS2(7), IARS(8), IARS2(20), KARS(5), LARS(18), LARS2(8), MARS(11), MARS2(4), NARS(10), NARS2(10), PARS2(4), QARS(7), RARS(13), RARS2(8), SARS(4), SARS2(4), TARS(9), TARS2(9), VARS(6), VARS2(1), WARS(6), WARS2(3), YARS(5), YARS2(3)	19060344	274	69	269	89	80	105	50	3	36	0	0.672	1.000	1.000
350	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	31	ADRA1A(12), ADRA1B(6), ADRA1D(1), ADRA2A(6), ADRA2C(2), ADRB2(7), ADRB3(3), CHRM1(6), CHRM2(10), CHRM3(8), CHRM4(9), CHRM5(9), DRD1(6), DRD2(8), DRD3(6), DRD5(11), HRH1(10), HRH2(4), HTR1A(14), HTR1B(6), HTR1D(6), HTR1E(11), HTR1F(11), HTR2A(11), HTR2B(2), HTR2C(16), HTR4(6), HTR5A(12), HTR6(4), HTR7(5)	8984624	228	69	220	83	89	83	42	3	11	0	0.0982	1.000	1.000
351	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	39	ALK(18), AR(12), ESR1(11), ESR2(5), ESRRA(2), HNF4A(12), NPM1(2), NR0B1(8), NR1D1(4), NR1D2(2), NR1H2(3), NR1H3(4), NR1I2(3), NR1I3(4), NR2C2(7), NR2E1(8), NR2F1(7), NR2F2(5), NR2F6(4), NR3C1(17), NR4A1(6), NR4A2(11), NR5A1(3), NR5A2(13), PGR(13), PPARA(2), PPARD(3), PPARG(6), RARA(2), RARB(3), RARG(6), ROR1(10), RORA(6), RORC(8), RXRA(3), RXRG(9), THRA(4), THRB(4), VDR(8)	14380270	258	69	248	79	95	87	44	3	28	1	0.102	1.000	1.000
352	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	63	ACSS1(5), ACSS2(5), ACYP1(2), ADH1A(2), ADH1B(5), ADH4(4), ADH6(9), ADH7(4), ADHFE1(5), AKR1A1(1), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(4), ALDH3A2(3), ALDH3B2(7), ALDH7A1(1), ALDH9A1(2), ALDOA(5), ALDOB(9), ALDOC(3), BPGM(1), DLAT(3), DLD(5), ENO1(6), ENO2(4), ENO3(5), FBP1(2), FBP2(1), G6PC(5), G6PC2(11), GALM(1), GAPDH(2), GAPDHS(10), GCK(2), GPI(7), HK1(11), HK2(9), HK3(9), LDHA(6), LDHAL6A(8), LDHAL6B(2), LDHB(3), LDHC(5), PDHA1(7), PDHA2(9), PDHB(3), PFKL(8), PFKM(8), PFKP(8), PGAM1(3), PGAM2(1), PGAM4(5), PGK1(7), PGK2(6), PGM1(6), PGM3(3), PKLR(6), TPI1(2)	20778184	293	68	290	107	92	111	52	2	36	0	0.564	1.000	1.000
353	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	ACHE(4), AGPAT2(2), AGPAT3(4), AGPAT4(5), AGPAT6(6), CDS1(5), CHAT(5), CHKA(9), CHKB(6), CHPT1(1), DGKA(9), DGKB(23), DGKD(18), DGKE(5), DGKG(11), DGKH(10), DGKI(18), DGKQ(2), DGKZ(10), ESCO1(16), ESCO2(8), ETNK1(9), ETNK2(3), GNPAT(11), GPAM(9), GPD1(3), GPD1L(4), GPD2(3), LCAT(4), LYPLA1(1), LYPLA2(7), NAT6(1), PCYT1A(3), PCYT1B(4), PEMT(1), PISD(2), PLA2G12A(1), PLA2G12B(4), PLA2G2D(2), PLA2G2E(5), PLA2G2F(3), PLA2G3(7), PLA2G4A(13), PLA2G5(1), PLA2G6(9), PLD1(13), PLD2(10), PNPLA3(7), PPAP2A(5), PPAP2B(3), PPAP2C(1), PTDSS1(5), PTDSS2(2), SH3GLB1(7)	23545860	340	68	336	129	104	119	67	3	45	2	0.857	1.000	1.000
354	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(56), CDH1(14), CREBBP(32), EP300(32), MAP2K1(2), MAP3K7(9), MAPK3(3), SKIL(7), TGFB1(1), TGFB2(5), TGFB3(9), TGFBR1(6), TGFBR2(6)	9444442	182	68	173	48	48	61	36	2	31	4	0.182	1.000	1.000
355	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	27	ARHGDIB(3), BAG4(5), CASP2(6), CASP3(4), CASP8(21), CRADD(3), DFFB(4), FADD(1), JUN(1), LMNA(7), LMNB1(5), LMNB2(4), MADD(16), MAP2K4(9), MAP3K1(30), MAP3K7(9), MAPK8(11), PAK1(3), PAK2(3), PRKDC(54), RB1(26), RIPK1(8), SPTAN1(31), TNFRSF1A(4), TRAF2(3)	14248497	271	68	263	82	74	78	52	4	59	4	0.466	1.000	1.000
356	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(8), AGTR1(4), ATF2(8), CALM1(2), CALM2(3), EGFR(12), ELK1(3), GNAQ(3), GRB2(3), HRAS(1), JUN(1), MAP2K1(2), MAP2K2(5), MAP2K4(9), MAP3K1(30), MAPK1(2), MAPK3(3), MAPK8(11), MEF2A(3), MEF2B(1), MEF2C(10), MEF2D(7), PAK1(3), PRKCA(11), PTK2(12), PTK2B(15), RAC1(1), RAF1(9), SHC1(6), SOS1(13), SRC(3), SYT1(4)	12424151	208	67	201	62	58	76	40	0	33	1	0.227	1.000	1.000
357	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(4), BTK(12), CALM1(2), CALM2(3), CD79A(1), CD79B(2), ELK1(3), FOS(3), GRB2(3), HRAS(1), JUN(1), LYN(9), MAP2K1(2), MAP3K1(30), MAPK14(4), MAPK3(3), MAPK8(11), NFATC1(10), NFATC2(13), NFATC3(11), NFATC4(5), PLCG1(12), PPP3CA(4), PPP3CB(6), PPP3CC(6), PRKCA(11), RAC1(1), RAF1(9), SHC1(6), SOS1(13), SYK(4), SYT1(4), VAV1(12)	13601950	221	67	213	67	64	77	47	1	31	1	0.262	1.000	1.000
358	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	ARHGDIB(3), CASP10(8), CASP3(4), CASP6(7), CASP7(1), CASP8(21), CFLAR(2), DAXX(9), DFFB(4), FADD(1), FAF1(10), JUN(1), LMNA(7), LMNB1(5), LMNB2(4), MAP2K4(9), MAP3K1(30), MAP3K7(9), MAPK8(11), PAK1(3), PAK2(3), PRKDC(54), PTPN13(29), RB1(26), RIPK2(6), SPTAN1(31)	15656179	298	67	289	80	75	95	55	4	64	5	0.257	1.000	1.000
359	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(8), CALM1(2), CALM2(3), CRKL(6), GNAQ(3), GRB2(3), HRAS(1), JUN(1), MAP2K1(2), MAP2K2(5), MAP2K3(7), MAP2K4(9), MAP3K1(30), MAPK1(2), MAPK14(4), MAPK3(3), MAPK8(11), PAK1(3), PLCG1(12), PRKCA(11), PTK2B(15), RAC1(1), RAF1(9), SHC1(6), SOS1(13), SRC(3), SYT1(4)	10198568	177	67	170	54	50	62	35	0	29	1	0.335	1.000	1.000
360	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	AANAT(2), ACAT1(6), ACAT2(4), ACMSD(8), ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(4), ALDH3A2(3), ALDH9A1(2), AOC2(7), AOC3(10), AOX1(18), ASMT(5), CAT(4), CYP19A1(13), CYP1A1(11), CYP1A2(11), CYP2A13(9), CYP2A6(13), CYP2A7(6), CYP2B6(14), CYP2C18(5), CYP2C19(6), CYP2C8(7), CYP2C9(5), CYP2D6(2), CYP2E1(2), CYP2F1(4), CYP2J2(5), CYP3A4(10), CYP3A5(6), CYP3A7(5), CYP4B1(4), CYP51A1(4), DDC(8), ECHS1(3), EHHADH(10), GCDH(4), HAAO(2), HADHA(5), KMO(8), KYNU(7), MAOA(12), MAOB(7), SDS(1), TDO2(3), TPH1(9), WARS(6), WARS2(3)	20087936	341	67	335	110	95	133	66	4	40	3	0.269	1.000	1.000
361	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	69	ADH1A(2), ADH1B(5), ADH4(4), ADH6(9), ADH7(4), ADHFE1(5), AKR1C1(6), AKR1C2(3), AKR1C3(2), AKR1C4(6), ALDH1A3(8), ALDH3A1(4), ALDH3B2(7), CYP1A1(11), CYP1A2(11), CYP1B1(2), CYP2B6(14), CYP2C18(5), CYP2C19(6), CYP2C8(7), CYP2C9(5), CYP2E1(2), CYP2F1(4), CYP2S1(8), CYP3A4(10), CYP3A43(4), CYP3A5(6), CYP3A7(5), DHDH(4), EPHX1(2), GSTA1(2), GSTA2(6), GSTA3(5), GSTA4(3), GSTA5(4), GSTK1(5), GSTM1(2), GSTM2(3), GSTM3(5), GSTM4(1), GSTM5(1), GSTO2(1), GSTP1(2), GSTT1(1), GSTT2(1), GSTZ1(5), MGST1(4), MGST3(2), UGT1A1(11), UGT1A10(7), UGT1A3(2), UGT1A4(3), UGT1A5(7), UGT1A6(5), UGT1A7(7), UGT1A9(3), UGT2A1(9), UGT2A3(5), UGT2B10(18), UGT2B11(8), UGT2B15(9), UGT2B17(7), UGT2B28(15), UGT2B4(11), UGT2B7(5)	20623799	356	66	344	93	95	144	68	3	46	0	0.0146	1.000	1.000
362	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(5), ACTN1(9), ACTN2(16), BCAR1(8), BCR(6), CAPN1(5), CAPNS1(2), CAPNS2(3), CAV1(2), CRKL(6), CSK(1), FYN(5), GRB2(3), HRAS(1), ITGA1(17), ITGB1(8), JUN(1), MAP2K1(2), MAP2K2(5), MAPK1(2), MAPK3(3), MAPK8(11), PPP1R12B(19), PTK2(12), PXN(6), RAF1(9), RAP1A(4), ROCK1(22), SHC1(6), SOS1(13), SRC(3), TLN1(23), VCL(11), ZYX(11)	16913420	260	66	252	70	93	84	47	0	34	2	0.0192	1.000	1.000
363	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(4), AGPAT2(2), AGPAT3(4), AGPAT4(5), AGPS(8), CDS1(5), CHAT(5), CHKA(9), CHKB(6), CLC(1), CPT1B(6), DGKA(9), DGKB(23), DGKD(18), DGKE(5), DGKG(11), DGKH(10), DGKQ(2), DGKZ(10), ETNK1(9), GNPAT(11), GPD1(3), GPD2(3), LCAT(4), LGALS13(1), LYPLA1(1), LYPLA2(7), PAFAH1B1(3), PAFAH2(2), PCYT1A(3), PCYT1B(4), PEMT(1), PISD(2), PLA2G2E(5), PLA2G3(7), PLA2G4A(13), PLA2G5(1), PLA2G6(9), PLCB2(8), PLCG1(12), PLCG2(27), PPAP2A(5), PPAP2B(3), PPAP2C(1)	17808076	288	65	283	106	91	99	60	3	32	3	0.716	1.000	1.000
364	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOA(5), ALDOB(9), ALDOC(3), DLAT(3), DLD(5), ENO1(6), ENO2(4), ENO3(5), FBP1(2), FBP2(1), G6PC(5), GAPDH(2), GAPDHS(10), GCK(2), GOT1(9), GOT2(3), GPI(7), HK1(11), HK2(9), HK3(9), LDHA(6), LDHAL6B(2), LDHB(3), LDHC(5), MDH1(2), MDH2(4), PC(12), PCK1(9), PDHA1(7), PDHA2(9), PDHB(3), PDHX(11), PFKL(8), PFKM(8), PFKP(8), PGAM1(3), PGAM2(1), PGK1(7), PGK2(6), PKLR(6), TNFAIP1(3), TPI1(2)	15179743	235	65	232	82	77	85	41	2	30	0	0.383	1.000	1.000
365	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	50	AKR1C3(2), ALOX12(8), ALOX12B(10), ALOX15(9), ALOX15B(6), ALOX5(10), CBR1(3), CBR3(2), CYP2B6(14), CYP2C18(5), CYP2C19(6), CYP2C8(7), CYP2C9(5), CYP2E1(2), CYP2J2(5), CYP2U1(2), CYP4A11(7), CYP4A22(7), CYP4F2(12), CYP4F3(8), EPHX2(7), GGT1(5), GPX2(1), GPX5(6), GPX6(7), GPX7(1), LTA4H(4), PLA2G12A(1), PLA2G12B(4), PLA2G2D(2), PLA2G2E(5), PLA2G2F(3), PLA2G3(7), PLA2G4A(13), PLA2G5(1), PLA2G6(9), PTGDS(4), PTGES(2), PTGES2(3), PTGIS(7), PTGS1(5), PTGS2(9), TBXAS1(7)	14108848	243	65	235	71	87	83	37	5	31	0	0.0700	1.000	1.000
366	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	41	ACACA(31), ACACB(29), ACAT1(6), ACAT2(4), ACOT12(11), ACSS1(5), ACSS2(5), ACYP1(2), AKR1B1(1), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(4), ALDH3A2(3), ALDH7A1(1), ALDH9A1(2), DLAT(3), DLD(5), GRHPR(2), LDHA(6), LDHAL6A(8), LDHAL6B(2), LDHB(3), LDHC(5), LDHD(2), MDH1(2), MDH2(4), ME1(12), ME2(8), ME3(9), PC(12), PCK1(9), PCK2(7), PDHA1(7), PDHA2(9), PDHB(3), PKLR(6)	16736435	245	65	238	89	76	89	40	5	33	2	0.659	1.000	1.000
367	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	AGMAT(3), ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(4), ALDH3A2(3), ALDH4A1(4), ALDH9A1(2), AMD1(3), AOC2(7), AOC3(10), ARG1(5), ARG2(3), ASL(2), CKM(3), CKMT1A(1), CKMT2(4), CPS1(22), DAO(8), GAMT(3), GATM(5), GLUD1(3), GOT1(9), GOT2(3), MAOA(12), MAOB(7), NOS1(18), NOS3(11), OAT(7), ODC1(2), OTC(7), P4HA1(6), P4HA2(12), P4HA3(3), P4HB(5), PYCR1(3), RARS(13), SMS(8)	15728089	259	64	254	88	84	91	47	6	29	2	0.380	1.000	1.000
368	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	52	ACYP1(2), ADH1A(2), ADH1B(5), ADH4(4), ADH6(9), ADH7(4), ADHFE1(5), AKR1A1(1), ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(4), ALDH3A2(3), ALDH3B2(7), ALDH9A1(2), ALDOA(5), ALDOB(9), ALDOC(3), BPGM(1), DLAT(3), DLD(5), ENO1(6), ENO2(4), ENO3(5), FBP1(2), FBP2(1), G6PC(5), GAPDH(2), GCK(2), GPI(7), HK1(11), HK2(9), HK3(9), LDHA(6), LDHB(3), LDHC(5), PDHA1(7), PDHA2(9), PDHB(3), PFKM(8), PFKP(8), PGAM1(3), PGK1(7), PGM1(6), PGM3(3), PKLR(6), TPI1(2)	17484356	251	64	249	87	76	91	45	2	37	0	0.406	1.000	1.000
369	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	AGXT(4), AGXT2(13), ALAS1(8), ALAS2(10), AMT(2), AOC2(7), AOC3(10), ATP6V0C(1), BHMT(2), CBS(11), CHDH(2), CHKA(9), CHKB(6), CPT1B(6), CTH(6), DAO(8), DLD(5), DMGDH(4), GAMT(3), GARS(8), GATM(5), GLDC(16), MAOA(12), MAOB(7), PEMT(1), PISD(2), PLCB2(8), PLCG1(12), PLCG2(27), PSPH(1), SARDH(8), SARS(4), SHMT1(5), SHMT2(5), TARS(9)	15209542	247	64	239	82	77	91	45	0	34	0	0.376	1.000	1.000
370	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	52	ACYP1(2), ADH1A(2), ADH1B(5), ADH4(4), ADH6(9), ADH7(4), ADHFE1(5), AKR1A1(1), ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(4), ALDH3A2(3), ALDH3B2(7), ALDH9A1(2), ALDOA(5), ALDOB(9), ALDOC(3), BPGM(1), DLAT(3), DLD(5), ENO1(6), ENO2(4), ENO3(5), FBP1(2), FBP2(1), G6PC(5), GAPDH(2), GCK(2), GPI(7), HK1(11), HK2(9), HK3(9), LDHA(6), LDHB(3), LDHC(5), PDHA1(7), PDHA2(9), PDHB(3), PFKM(8), PFKP(8), PGAM1(3), PGK1(7), PGM1(6), PGM3(3), PKLR(6), TPI1(2)	17484356	251	64	249	87	76	91	45	2	37	0	0.406	1.000	1.000
371	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(1), AKR1B10(4), B4GALT1(2), B4GALT2(5), G6PC(5), G6PC2(11), GAA(4), GALK1(1), GALK2(3), GALT(3), GANC(15), GCK(2), GLA(9), GLB1(6), HK1(11), HK2(9), HK3(9), HSD3B7(5), LALBA(2), LCT(32), MGAM(38), PFKL(8), PFKM(8), PFKP(8), PGM1(6), PGM3(3), RDH11(1), RDH12(5), RDH13(4), RDH14(2), UGP2(6)	13671150	228	64	224	81	73	80	42	3	30	0	0.503	1.000	1.000
372	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(7), AARS2(6), ABAT(9), ACY3(3), ADSL(8), ADSS(6), ADSSL1(5), AGXT(4), AGXT2(13), ASL(2), ASNS(9), ASPA(5), ASS1(1), CAD(25), CRAT(3), DARS(7), DARS2(10), DDO(7), DLAT(3), DLD(5), GAD1(6), GAD2(12), GOT1(9), GOT2(3), GPT(2), GPT2(5), NARS(10), NARS2(10), PC(12), PDHA1(7), PDHA2(9), PDHB(3)	13551574	226	64	220	78	52	88	37	5	44	0	0.554	1.000	1.000
373	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(9), ACAA1(5), ACAA2(3), ACADM(9), ACADS(3), ACAT1(6), ACAT2(4), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(4), ALDH3A2(3), ALDH6A1(6), ALDH7A1(1), ALDH9A1(2), AOX1(18), AUH(4), BCAT1(7), BCAT2(3), BCKDHA(5), BCKDHB(4), DBT(5), DLD(5), ECHS1(3), EHHADH(10), HADH(1), HADHA(5), HADHB(4), HIBADH(5), HIBCH(6), HMGCL(2), HMGCS1(6), HMGCS2(9), HSD17B10(4), HSD17B4(12), IVD(2), MCCC1(8), MCCC2(5), MCEE(1), MUT(10), OXCT1(10), OXCT2(2), PCCA(6), PCCB(8)	15810646	242	64	238	71	60	95	54	2	31	0	0.209	1.000	1.000
374	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(4), ALPL(5), ALPP(3), ALPPL2(3), ASCC3(31), ATP13A2(5), DDX18(12), DDX19A(4), DDX23(9), DDX4(15), DDX41(3), DDX47(5), DDX50(10), DDX51(8), DDX52(4), DDX54(8), DDX55(6), DDX56(5), DHFR(4), DHX58(6), ENTPD7(8), EP400(42), ERCC2(1), ERCC3(11), FPGS(5), GCH1(1), GGH(2), IFIH1(5), MOV10L1(19), NUDT5(2), NUDT8(1), PTS(1), RAD54B(14), RAD54L(6), RUVBL2(4), SETX(33), SKIV2L2(17), SMARCA2(24), SMARCA5(19), SPR(1)	22546741	366	64	351	97	125	111	81	4	39	6	0.0231	1.000	1.000
375	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	28	AGA(7), ARSB(5), FUCA1(3), FUCA2(4), GALNS(4), GBA(4), GLB1(6), GNS(5), GUSB(5), HEXA(3), HEXB(5), HGSNAT(10), HPSE(6), HPSE2(11), HYAL1(2), HYAL2(4), IDS(8), IDUA(5), LCT(32), MAN2B1(14), MAN2B2(5), MAN2C1(7), MANBA(12), NAGLU(3), NEU2(4), NEU3(3), SPAM1(15)	11933424	192	64	191	77	49	82	36	3	22	0	0.871	1.000	1.000
376	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	92	ANK2(39), B3GALT4(3), CDR1(2), DGKI(18), IL6ST(11), MRPL19(6), PIGK(9), RPL10(4), RPL11(3), RPL13(1), RPL13A(1), RPL14(2), RPL15(2), RPL17(6), RPL18(1), RPL18A(2), RPL19(4), RPL21(3), RPL22(5), RPL23(1), RPL24(2), RPL27(1), RPL27A(3), RPL28(2), RPL29(2), RPL3(2), RPL34(1), RPL35A(2), RPL37(2), RPL38(1), RPL39(4), RPL3L(3), RPL4(4), RPL5(7), RPL6(3), RPL7(1), RPL7A(2), RPL8(2), RPL9(2), RPLP0(5), RPS10(1), RPS11(1), RPS12(2), RPS13(1), RPS15(1), RPS16(1), RPS18(3), RPS2(1), RPS20(3), RPS21(1), RPS24(2), RPS25(2), RPS27(1), RPS27A(4), RPS28(1), RPS29(2), RPS3(3), RPS3A(1), RPS4X(1), RPS6(7), RPS6KA1(1), RPS6KA2(13), RPS6KA3(19), RPS6KA6(19), RPS6KB1(3), RPS6KB2(4), RPS7(5), RPS8(2), RPSA(1), SLC36A2(6), TBC1D10C(1), TSPAN9(4), UBA52(1), UBB(2), UBC(8)	19078569	302	63	293	114	83	111	62	2	41	3	0.983	1.000	1.000
377	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(1), AKR1B10(4), ALDOA(5), ALDOB(9), ALDOC(3), FBP1(2), FBP2(1), FPGT(6), FUK(8), GMDS(4), GMPPA(4), GMPPB(2), HK1(11), HK2(9), HK3(9), HSD3B7(5), KHK(2), LHPP(2), MPI(5), MTMR1(16), MTMR2(5), MTMR6(10), PFKFB1(8), PFKFB2(4), PFKFB3(4), PFKFB4(4), PFKL(8), PFKM(8), PFKP(8), PGM2(8), PHPT1(1), PMM2(6), RDH11(1), RDH12(5), RDH13(4), RDH14(2), SORD(5), TPI1(2), TSTA3(3)	13401284	204	62	199	78	75	60	35	2	32	0	0.658	1.000	1.000
378	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	53	AKR1C4(6), AKR1D1(8), ARSD(5), ARSE(10), CARM1(5), CYP11B1(8), CYP11B2(8), CYP19A1(13), HEMK1(2), HSD11B1(6), HSD17B1(4), HSD17B12(4), HSD17B2(2), HSD17B3(7), HSD17B7(5), HSD17B8(2), HSD3B1(3), HSD3B2(6), LCMT1(2), LCMT2(9), METTL2B(4), METTL6(4), PRMT2(1), PRMT3(8), PRMT5(10), PRMT6(5), PRMT7(5), PRMT8(7), SRD5A1(4), STS(8), SULT1E1(9), SULT2A1(7), SULT2B1(4), UGT1A1(11), UGT1A10(7), UGT1A3(2), UGT1A4(3), UGT1A5(7), UGT1A6(5), UGT1A7(7), UGT1A9(3), UGT2A1(9), UGT2A3(5), UGT2B10(18), UGT2B11(8), UGT2B15(9), UGT2B17(7), UGT2B28(15), UGT2B4(11), UGT2B7(5), WBSCR22(2)	17574364	325	62	313	102	71	149	52	3	48	2	0.233	1.000	1.000
379	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(9), ALDH4A1(4), ALDH5A1(7), CAD(25), CPS1(22), EARS2(5), EPRS(15), GAD1(6), GAD2(12), GCLC(8), GCLM(2), GFPT1(9), GFPT2(12), GLS(11), GLS2(7), GLUD1(3), GLUD2(9), GLUL(7), GMPS(14), GNPNAT1(2), GOT1(9), GOT2(3), GPT(2), GPT2(5), GSR(6), GSS(5), NADSYN1(6), NAGK(2), PPAT(9), QARS(7)	14398876	243	62	237	76	73	77	47	4	40	2	0.284	1.000	1.000
380	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(5), ACAA2(3), ACADL(8), ACADM(9), ACADS(3), ACADSB(6), ACADVL(9), ACAT1(6), ACAT2(4), ACOX1(7), ACOX3(8), ACSL1(13), ACSL3(7), ACSL4(21), ACSL5(8), ACSL6(12), ADH1A(2), ADH1B(5), ADH4(4), ADH6(9), ADH7(4), ADHFE1(5), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(4), ALDH3A2(3), ALDH7A1(1), ALDH9A1(2), CPT1A(9), CPT1B(6), CPT1C(15), CPT2(4), CYP4A11(7), CYP4A22(7), ECHS1(3), EHHADH(10), GCDH(4), HADH(1), HADHA(5), HADHB(4), HSD17B10(4), HSD17B4(12)	17830726	276	61	270	82	79	94	61	2	40	0	0.105	1.000	1.000
381	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	AGXT(4), AGXT2(13), AKR1B10(4), ALAS1(8), ALAS2(10), AMT(2), AOC2(7), AOC3(10), BHMT(2), CBS(11), CHDH(2), CHKA(9), CHKB(6), CTH(6), DAO(8), DLD(5), DMGDH(4), GAMT(3), GARS(8), GATM(5), GLDC(16), GNMT(3), HSD3B7(5), MAOA(12), MAOB(7), PEMT(1), PHGDH(5), PIPOX(4), PISD(2), PSAT1(5), PSPH(1), RDH11(1), RDH12(5), RDH13(4), RDH14(2), SARDH(8), SARS(4), SARS2(4), SDS(1), SHMT1(5), SHMT2(5), TARS(9), TARS2(9)	15514922	245	61	238	91	76	93	42	1	33	0	0.676	1.000	1.000
382	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(2), ALG10(6), ALG10B(6), ALG11(6), ALG12(6), ALG13(24), ALG14(2), ALG2(2), ALG5(2), ALG6(5), ALG8(11), ALG9(2), B4GALT1(2), B4GALT2(5), B4GALT3(10), DAD1(2), DDOST(3), DHDDS(4), DOLPP1(2), DPAGT1(3), DPM1(2), FUT8(10), GANAB(10), MAN1A1(13), MAN1A2(7), MAN1B1(5), MAN1C1(6), MAN2A1(20), MGAT1(4), MGAT2(4), MGAT3(4), MGAT4A(5), MGAT4B(6), MGAT5(11), MGAT5B(10), RFT1(6), RPN1(3), RPN2(5), ST6GAL1(7), STT3B(5)	15130995	248	61	235	66	80	80	53	1	33	1	0.0523	1.000	1.000
383	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(9), ACACA(31), ACACB(29), ACADM(9), ACAT1(6), ACAT2(4), ACSS1(5), ACSS2(5), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(4), ALDH3A2(3), ALDH6A1(6), ALDH7A1(1), ALDH9A1(2), ECHS1(3), EHHADH(10), HADHA(5), HIBCH(6), LDHA(6), LDHAL6A(8), LDHAL6B(2), LDHB(3), LDHC(5), MCEE(1), MLYCD(3), MUT(10), PCCA(6), PCCB(8), SUCLA2(5), SUCLG1(5), SUCLG2(10)	14485204	227	61	222	63	59	83	51	5	27	2	0.121	1.000	1.000
384	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(7), AADAC(6), ABAT(9), ACADS(3), ACAT1(6), ACAT2(4), ACSM1(12), AKR1B10(4), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(4), ALDH3A2(3), ALDH5A1(7), ALDH7A1(1), ALDH9A1(2), BDH1(3), BDH2(4), DDHD1(9), ECHS1(3), EHHADH(10), GAD1(6), GAD2(12), HADH(1), HADHA(5), HMGCL(2), HMGCS1(6), HMGCS2(9), HSD17B10(4), HSD17B4(12), HSD3B7(5), ILVBL(8), L2HGDH(5), OXCT1(10), OXCT2(2), PDHA1(7), PDHA2(9), PDHB(3), PLA1A(6), PPME1(3), PRDX6(4), RDH11(1), RDH12(5), RDH13(4), RDH14(2)	14787189	245	61	236	77	75	83	46	6	34	1	0.199	1.000	1.000
385	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2A1(3), GTF2A1L(6), GTF2B(5), GTF2E1(3), GTF2E2(2), GTF2F1(7), GTF2F2(1), GTF2H1(9), GTF2H3(3), GTF2H4(3), GTF2I(4), GTF2IRD1(7), STON1(6), TAF1(58), TAF10(1), TAF1L(40), TAF2(19), TAF4(10), TAF4B(4), TAF5(8), TAF5L(5), TAF6(9), TAF6L(5), TAF7(4), TAF7L(10), TAF9(4), TAF9B(12), TBPL1(5), TBPL2(5)	12968048	258	61	251	65	84	95	47	2	29	1	0.0810	1.000	1.000
386	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(12), ADRBK2(15), ARRB2(5), CALM1(2), CALM2(3), CALML3(3), CALML6(4), CAMK2A(9), CAMK2B(4), CAMK2D(5), CAMK2G(5), CLCA1(15), CLCA2(10), CLCA4(15), CNGA3(13), CNGA4(9), CNGB1(13), GNAL(6), GUCA1A(4), GUCA1B(2), GUCA1C(4), PDC(1), PDE1C(11), PRKACA(6), PRKACB(3), PRKACG(9), PRKG1(11), PRKG2(11), PRKX(2)	11219988	212	61	208	70	61	81	33	2	33	2	0.335	1.000	1.000
387	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(2), ALOX12(8), ALOX15(9), ALOX5(10), CBR1(3), CBR3(2), CYP4F2(12), CYP4F3(8), EPX(15), GGT1(5), LPO(6), LTA4H(4), MPO(8), PLA2G2E(5), PLA2G3(7), PLA2G4A(13), PLA2G5(1), PLA2G6(9), PRDX2(2), PRDX5(1), PRDX6(4), PTGDS(4), PTGES2(3), PTGIS(7), PTGS1(5), PTGS2(9), TBXAS1(7), TPO(14)	10064017	183	61	175	61	75	57	26	5	20	0	0.275	1.000	1.000
388	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(4), ARG1(5), ARG2(3), ASL(2), ASS1(1), CKM(3), CKMT1A(1), CKMT2(4), CPS1(22), DAO(8), EPRS(15), GAMT(3), GATM(5), GLUD1(3), GLUD2(9), GOT1(9), GOT2(3), LAP3(10), NOS1(18), NOS3(11), OAT(7), OTC(7), P4HA1(6), P4HA2(12), P4HA3(3), PARS2(4), PRODH(10), PYCR1(3), PYCR2(2), PYCRL(1), RARS(13), RARS2(8)	12782303	215	60	211	82	67	79	38	5	24	2	0.810	1.000	1.000
389	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(8), CREBBP(32), DUSP1(2), EP300(32), IKBKB(13), IL1B(2), MAP2K3(7), MAP2K6(10), MAP3K7(9), MAPK11(3), MAPK14(4), MYD88(2), NFKB1(10), NFKBIA(3), NR3C1(17), RELA(6), TGFBR1(6), TGFBR2(6), TLR2(16)	10691056	188	60	181	49	53	59	41	1	33	1	0.109	1.000	1.000
390	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	ATF2(8), BCR(6), BLNK(4), ELK1(3), FOS(3), GRB2(3), HRAS(1), JUN(1), LYN(9), MAP2K1(2), MAP3K1(30), MAPK1(2), MAPK3(3), MAPK8IP3(9), PAPPA(27), RAC1(1), RPS6KA1(1), RPS6KA3(19), SHC1(6), SOS1(13), SYK(4), VAV1(12), VAV2(7), VAV3(13)	11251667	187	60	181	57	51	69	38	1	27	1	0.270	1.000	1.000
391	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	34	AKT1(4), ATF1(6), CDC42(3), CREB1(5), CREB5(5), DUSP1(2), DUSP10(5), EEF2K(11), EIF4E(1), ELK1(3), IL1R1(5), MAP2K3(7), MAP2K4(9), MAP2K6(10), MAP3K10(7), MAP3K4(21), MAP3K5(25), MAP3K7(9), MAPK1(2), MAPK11(3), MAPK12(2), MAPK13(4), MAPK14(4), MAPKAPK2(5), MAPKAPK5(5), MKNK1(3), MKNK2(2), MYEF2(7), NFKB1(10), NR2C2(7), SRF(3), TRAF6(7)	11929413	202	60	199	60	67	69	39	1	26	0	0.202	1.000	1.000
392	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	46	APAF1(17), BAD(1), BAX(2), BCL2L1(4), BCL2L2(2), BOK(2), CASP1(8), CASP10(8), CASP2(6), CASP3(4), CASP4(5), CASP6(7), CASP7(1), CASP8(21), CASP9(3), CD40(1), CD40LG(6), CRADD(3), CYCS(2), DAXX(9), DFFB(4), FADD(1), FAS(8), FASLG(7), IKBKE(4), LTA(3), MCL1(1), NFKB1(10), NFKBIA(3), NGFR(3), NR3C1(17), NTRK1(13), PTPN13(29), RIPK1(8), TFG(4), TNFRSF1A(4), TNFRSF1B(2), TRAF1(5), TRAF2(3), TRAF3(5), TRAF6(7)	15655494	253	59	247	80	58	96	47	2	49	1	0.493	1.000	1.000
393	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	DPM2(1), EGFR(12), ELK1(3), GNAS(24), GNB1(2), GNGT1(1), GRB2(3), HRAS(1), IGF1R(13), ITGB1(8), KLK2(2), MAP2K1(2), MAP2K2(5), MAPK1(2), MAPK3(3), MKNK1(3), MKNK2(2), MYC(8), NGFR(3), PDGFRA(24), PPP2CA(6), PTPRR(17), RAF1(9), RPS6KA1(1), RPS6KA5(11), SHC1(6), SOS1(13), SRC(3), STAT3(11)	11799432	199	59	190	49	53	74	43	1	27	1	0.0232	1.000	1.000
394	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(9), CAMK2B(4), CAMK2D(5), CAMK2G(5), DAG1(6), ITPKA(1), ITPKB(11), ITPR1(34), ITPR2(35), ITPR3(22), NFAT5(16), PDE6A(10), PDE6B(5), PDE6C(12), PDE6D(2), PDE6G(1), PDE6H(1), SLC6A13(8), TF(13)	13059603	200	59	198	69	56	85	24	1	32	2	0.318	1.000	1.000
395	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(12), F11(15), F12(2), F13B(15), F2(8), F5(47), F7(2), F8(45), F9(14), FGA(26), FGB(7), FGG(9), LPA(14), PLAT(6), PLG(14), SERPINB2(9), SERPINE1(5), SERPINF2(4), VWF(25)	12712243	279	58	263	79	65	127	50	0	36	1	0.133	1.000	1.000
396	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CALM1(2), CALM2(3), CAMK1(3), CAMK1G(5), ELK1(3), FPR1(2), GNA15(1), GNB1(2), GNGT1(1), HRAS(1), MAP2K1(2), MAP2K2(5), MAP2K3(7), MAP2K6(10), MAP3K1(30), MAPK1(2), MAPK14(4), MAPK3(3), NCF1(2), NCF2(8), NFATC1(10), NFATC2(13), NFATC3(11), NFATC4(5), NFKB1(10), NFKBIA(3), PAK1(3), PIK3C2G(16), PLCB1(5), PPP3CA(4), PPP3CB(6), PPP3CC(6), RAC1(1), RAF1(9), RELA(6), SYT1(4)	13841989	208	58	203	69	60	72	40	2	33	1	0.448	1.000	1.000
397	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	B2M(3), CALR(3), CANX(4), CD4(6), CD74(1), CD8A(2), CD8B(1), CIITA(15), CREB1(5), CTSS(4), HLA-A(1), HLA-B(2), HLA-C(2), HLA-DMA(3), HLA-DOA(2), HLA-DOB(2), HLA-DPB1(1), HLA-DQA1(1), HLA-DQA2(1), HLA-DQB1(1), HLA-DRA(1), HLA-DRB5(1), HLA-E(1), HLA-F(2), HLA-G(2), HSP90AA1(7), HSP90AB1(21), HSPA5(6), IFI30(1), IFNA1(2), IFNA10(3), IFNA13(3), IFNA14(4), IFNA16(3), IFNA17(3), IFNA2(2), IFNA21(1), IFNA4(3), IFNA5(5), IFNA6(2), IFNA7(1), IFNA8(3), KIR2DL3(1), KIR3DL1(10), KIR3DL2(5), KIR3DL3(3), KLRC1(7), KLRC2(1), KLRC3(2), KLRC4(5), KLRD1(3), LGMN(7), LTA(3), NFYA(9), NFYB(2), NFYC(3), PDIA3(5), PSME1(1), PSME2(3), RFX5(8), RFXANK(4), RFXAP(2), TAP1(8), TAP2(1), TAPBP(4)	15021381	234	58	225	65	60	104	38	0	30	2	0.0583	1.000	1.000
398	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(7), ABAT(9), ADSL(8), ADSS(6), AGXT(4), AGXT2(13), ASL(2), ASNS(9), ASPA(5), CAD(25), CRAT(3), DARS(7), DDO(7), GAD1(6), GAD2(12), GOT1(9), GOT2(3), GPT(2), GPT2(5), NARS(10), PC(12)	9296781	164	57	160	52	41	59	27	4	33	0	0.306	1.000	1.000
399	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(1), B4GALT1(2), B4GALT2(5), FBP2(1), G6PC(5), GAA(4), GALK1(1), GALK2(3), GALT(3), GANAB(10), GCK(2), GLA(9), GLB1(6), HK1(11), HK2(9), HK3(9), LALBA(2), LCT(32), MGAM(38), PFKM(8), PFKP(8), PGM1(6), PGM3(3)	11638492	178	57	175	73	54	65	32	2	25	0	0.865	1.000	1.000
400	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(11), ACO1(17), ACO2(7), CLYBL(6), CS(6), DLD(5), DLST(8), FH(8), IDH1(4), IDH2(5), IDH3A(3), IDH3B(3), IDH3G(9), MDH1(2), MDH2(4), OGDH(13), OGDHL(19), PC(12), PCK1(9), PCK2(7), SDHA(14), SDHB(2), SDHC(2), SDHD(3), SUCLA2(5), SUCLG1(5), SUCLG2(10)	10928355	199	57	195	71	79	60	35	4	21	0	0.387	1.000	1.000
401	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	29	B4GALT5(2), C1GALT1(2), C1GALT1C1(6), GALNT1(10), GALNT10(8), GALNT11(12), GALNT12(6), GALNT13(18), GALNT14(6), GALNT2(10), GALNT3(8), GALNT4(8), GALNT5(5), GALNT6(1), GALNT7(12), GALNT8(11), GALNT9(8), GALNTL5(11), GCNT1(5), GCNT3(5), GCNT4(1), OGT(17), ST3GAL1(2), ST3GAL2(6), ST6GALNAC1(4), WBSCR17(15)	11810588	199	57	195	64	56	73	40	1	28	1	0.516	1.000	1.000
402	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	24	ATM(54), BMPR1B(6), CCND2(9), CDK4(2), CDKN1B(7), DAZL(6), DMC1(5), EGR1(6), ESR2(5), FSHR(15), GJA4(1), INHA(1), LHCGR(17), MLH1(7), MSH5(8), NCOR1(22), NR5A1(3), NRIP1(17), PGR(13), PRLR(5), PTGER2(3), SMPD1(4), VDR(8), ZP2(12)	12345156	236	57	228	60	46	90	38	5	49	8	0.146	1.000	1.000
403	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	36	ACACA(31), ACAT1(6), ACAT2(4), ACYP1(2), AKR1B1(1), ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(4), ALDH3A2(3), ALDH9A1(2), DLAT(3), DLD(5), GRHPR(2), LDHA(6), LDHB(3), LDHC(5), LDHD(2), MDH1(2), MDH2(4), ME1(12), ME2(8), ME3(9), PC(12), PCK1(9), PDHA1(7), PDHA2(9), PDHB(3), PKLR(6)	13180165	198	57	195	66	56	73	36	4	28	1	0.475	1.000	1.000
404	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(9), ACADL(8), ACADM(9), ACADSB(6), ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(4), ALDH3A2(3), ALDH9A1(2), AOC2(7), AOC3(10), CNDP1(4), DPYD(20), DPYS(6), ECHS1(3), EHHADH(10), GAD1(6), GAD2(12), HADHA(5), MLYCD(3), SDS(1), SMS(8), UPB1(10)	10447050	184	56	181	64	48	65	44	3	24	0	0.410	1.000	1.000
405	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	31	APAF1(17), BID(2), BIRC2(10), BIRC3(5), CASP10(8), CASP3(4), CASP6(7), CASP7(1), CASP8(21), CASP9(3), CFLAR(2), CHUK(8), CYCS(2), DFFB(4), FADD(1), GAS2(7), LMNA(7), NFKB1(10), NFKBIA(3), RELA(6), RIPK1(8), SPTAN1(31), TNFRSF10A(2), TNFRSF10B(5), TNFRSF25(2), TNFSF10(1), TNFSF12(6), TRAF2(3)	11978937	186	56	180	50	49	71	20	2	44	0	0.167	1.000	1.000
406	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(9), ALDH4A1(4), ALDH5A1(7), CAD(25), CPS1(22), EPRS(15), GAD1(6), GAD2(12), GCLC(8), GCLM(2), GFPT1(9), GLS(11), GLS2(7), GLUD1(3), GLUL(7), GMPS(14), GOT1(9), GOT2(3), GPT(2), GPT2(5), GSS(5), NADSYN1(6), PPAT(9), QARS(7)	12092421	207	56	201	63	54	68	43	4	36	2	0.337	1.000	1.000
407	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	40	ACY3(3), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(4), ALDH3A2(3), ALDH3B2(7), ALDH7A1(1), ALDH9A1(2), AMDHD1(13), AOC2(7), AOC3(10), ASPA(5), CARM1(5), CNDP1(4), DDC(8), FTCD(7), HAL(6), HARS(5), HARS2(7), HDC(9), HEMK1(2), HNMT(2), LCMT1(2), LCMT2(9), MAOA(12), MAOB(7), METTL2B(4), METTL6(4), PRMT2(1), PRMT3(8), PRMT5(10), PRMT6(5), PRMT7(5), PRMT8(7), PRPS1(2), PRPS2(4), UROC1(9), WBSCR22(2)	13908656	218	56	212	77	65	82	39	3	29	0	0.482	1.000	1.000
408	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(9), ACACA(31), ACADL(8), ACADM(9), ACADSB(6), ACAT1(6), ACAT2(4), ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(4), ALDH3A2(3), ALDH6A1(6), ALDH9A1(2), ECHS1(3), EHHADH(10), HADHA(5), LDHA(6), LDHB(3), LDHC(5), MCEE(1), MLYCD(3), MUT(10), PCCA(6), PCCB(8), SDS(1), SUCLA2(5), SUCLG1(5), SUCLG2(10)	12101964	207	56	204	57	46	71	53	4	32	1	0.165	1.000	1.000
409	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	ATF1(6), BAD(1), BRAF(10), CREB1(5), CREB5(5), DUSP6(2), DUSP9(1), EEF2K(11), EIF4E(1), GRB2(3), MAP2K1(2), MAP2K2(5), MAP3K8(10), MAPK1(2), MAPK3(3), MKNK1(3), MKNK2(2), MOS(6), NFKB1(10), RAP1A(4), RPS6KA1(1), RPS6KA2(13), RPS6KA3(19), SHC1(6), SOS1(13), SOS2(17), TRAF3(5)	10740371	166	56	162	60	48	59	35	1	21	2	0.669	1.000	1.000
410	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(12), DLG4(10), EPHB2(11), F2(8), F2RL1(4), F2RL2(2), JUN(1), MAP2K5(3), MAPK1(2), MAPK7(14), MAPK8(11), MYEF2(7), PLD1(13), PLD2(10), PLD3(5), PTK2(12), RAF1(9), RASAL1(14), SRC(3), TEC(7), VAV1(12)	10013158	170	56	167	62	56	55	28	3	27	1	0.737	1.000	1.000
411	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(56), ASAH1(6), CAMP(1), CASP3(4), CERK(7), CREB1(5), CREB5(5), CXCL2(2), DAG1(6), EPHB2(11), FOS(3), GNAQ(3), ITPKA(1), ITPKB(11), JUN(1), MAP2K4(9), MAP2K7(4), MAPK1(2), MAPK10(10), MAPK8(11), MAPK8IP1(4), MAPK8IP2(1), MAPK8IP3(9), MAPK9(4)	9812900	176	56	172	57	45	67	20	1	40	3	0.318	1.000	1.000
412	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(5), ACAA2(3), ACADL(8), ACADM(9), ACADS(3), ACADSB(6), ACAT1(6), ACAT2(4), ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(4), ALDH3A2(3), ALDH6A1(6), ALDH9A1(2), AOX1(18), BCAT1(7), BCKDHA(5), BCKDHB(4), ECHS1(3), EHHADH(10), HADHA(5), HADHB(4), HIBADH(5), HMGCL(2), IVD(2), MCCC1(8), MCCC2(5), MCEE(1), MUT(10), OXCT1(10), PCCA(6), PCCB(8), SDS(1)	13157737	211	56	208	70	52	79	47	2	31	0	0.476	1.000	1.000
413	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM1(2), CALM2(3), CHUK(8), EGR2(6), EGR3(7), GNAQ(3), MAP3K1(30), MYC(8), NFATC1(10), NFATC2(13), NFKB1(10), NFKBIA(3), PLCG1(12), PPP3CA(4), PPP3CB(6), PPP3CC(6), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), RELA(6), SYT1(4), VIP(4), VIPR2(4)	9816248	176	56	171	55	49	65	32	2	26	2	0.264	1.000	1.000
414	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	35	ARSA(3), ARSD(5), ARSE(10), ASAH1(6), B4GALT6(6), CERK(7), DEGS1(5), DEGS2(3), ENPP7(3), GAL3ST1(7), GALC(8), GBA(4), GLA(9), GLB1(6), LCT(32), NEU2(4), NEU3(3), PPAP2A(5), PPAP2B(3), PPAP2C(1), SGMS1(5), SGMS2(5), SGPP1(2), SGPP2(4), SMPD1(4), SMPD2(6), SMPD3(7), SMPD4(8), SPHK1(2), SPHK2(2), SPTLC1(5), SPTLC2(5), UGCG(4), UGT8(14)	12070767	203	55	199	60	51	93	31	3	25	0	0.0806	1.000	1.000
415	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CCNH(7), CDK7(7), ERCC3(11), GTF2B(5), GTF2E1(3), GTF2E2(2), GTF2F2(1), GTF2H1(9), GTF2H4(3), ILK(5), POLR1A(15), POLR1B(16), POLR2A(21), POLR2B(21), POLR2C(5), POLR2E(1), POLR2F(1), POLR2H(3), POLR2J(1), POLR2K(2), POLR3B(14), POLR3D(3), POLR3E(4), POLR3H(4), TAF5(8), TAF6(9), TAF7(4), TAF9(4), TBP(3)	12564504	192	55	191	59	66	62	29	2	32	1	0.346	1.000	1.000
416	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(21), CALM1(2), CALM2(3), CREB1(5), ELK1(3), FOS(3), GNAI1(5), GNAQ(3), GNAS(24), GNB1(2), GNGT1(1), HRAS(1), JUN(1), MAP2K1(2), MAPK3(3), NFATC1(10), NFATC2(13), NFATC3(11), NFATC4(5), PLCG1(12), PPP3CA(4), PPP3CB(6), PPP3CC(6), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PRKCA(11), RAF1(9), RPS6KA3(19), SYT1(4)	12116635	216	54	208	71	80	62	42	1	30	1	0.264	1.000	1.000
417	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(6), AASDH(10), AASDHPPT(9), AASS(12), ACAT1(6), ACAT2(4), ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(4), ALDH3A2(3), ALDH9A1(2), ATP6V0C(1), BBOX1(1), DLST(8), DOT1L(8), ECHS1(3), EHHADH(10), EHMT1(23), EHMT2(2), GCDH(4), HADHA(5), PLOD1(4), PLOD2(11), PLOD3(6), SDS(1), SHMT1(5), SHMT2(5), TMLHE(6)	12530482	197	54	192	74	65	66	39	5	21	1	0.573	1.000	1.000
418	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(4), AP2A1(7), AP2M1(6), ARF1(3), BAD(1), BTK(12), EEA1(17), GRASP(4), GSK3A(10), GSK3B(13), LYN(9), PDPK1(3), PFKL(8), PFKM(8), PFKP(8), PLCG1(12), PRKCE(10), PRKCZ(2), RAB5A(2), RAC1(1), RPS6KB1(3), VAV2(7)	8954356	150	54	145	55	57	47	24	0	22	0	0.559	1.000	1.000
419	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(4), ALOX15(9), ALOX5(10), CYP1A2(11), CYP2C18(5), CYP2C19(6), CYP2C8(7), CYP2C9(5), CYP2E1(2), CYP2J2(5), CYP3A4(10), CYP3A43(4), CYP3A5(6), CYP3A7(5), HSD3B7(5), PLA2G12A(1), PLA2G12B(4), PLA2G2D(2), PLA2G2E(5), PLA2G2F(3), PLA2G3(7), PLA2G4A(13), PLA2G5(1), PLA2G6(9), RDH11(1), RDH12(5), RDH13(4), RDH14(2)	8757420	151	53	146	43	47	53	22	4	25	0	0.138	1.000	1.000
420	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOA(5), ALDOB(9), ALDOC(3), FBP1(2), FBP2(1), GOT1(9), GOT2(3), GPT(2), GPT2(5), MDH1(2), MDH2(4), ME1(12), ME3(9), PGK1(7), PGK2(6), PKLR(6), RPE(5), RPIA(9), TKT(6), TKTL1(9), TKTL2(16), TPI1(2)	7208802	132	53	128	39	42	56	18	2	14	0	0.110	1.000	1.000
421	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(29), APOA1(3), APOA4(3), APOC1(3), APOC3(1), APOE(1), CETP(5), CYP7A1(11), DGAT1(3), HMGCR(12), LCAT(4), LDLR(7), LIPC(8), LPL(16), LRP1(51), SCARB1(6), SOAT1(9)	9737188	172	53	169	46	66	54	36	0	15	1	0.0275	1.000	1.000
422	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	38	ARNTL(7), AZIN1(8), CBX3(4), CLOCK(9), CRY1(9), CRY2(3), DNAJA1(3), EIF4G2(7), ETV6(6), GFRA1(9), GSTM3(5), GSTP1(2), HERPUD1(2), HSPA8(8), IDI1(3), KLF9(3), MYF6(8), NCKAP1(8), NCOA4(7), NR1D2(2), PER1(10), PER2(13), PIGF(2), PPP1R3C(4), PPP2CB(4), PSMA4(2), SF3A3(8), SUMO3(3), TOB1(4), TUBB3(6), UGP2(6), VAPA(5), ZFR(10)	13167207	190	52	185	59	59	69	37	2	23	0	0.443	1.000	1.000
423	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(9), ACADM(9), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(4), ALDH3A2(3), ALDH7A1(1), ALDH9A1(2), AOC2(7), AOC3(10), CNDP1(4), DPYD(20), DPYS(6), ECHS1(3), EHHADH(10), GAD1(6), GAD2(12), HADHA(5), HIBCH(6), MLYCD(3), SMS(8), SRM(1), UPB1(10)	9640368	156	52	153	49	43	58	35	3	17	0	0.205	1.000	1.000
424	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(4), CHIA(3), CHIT1(6), CMAS(7), CTBS(4), CYB5R1(3), CYB5R3(4), GFPT1(9), GFPT2(12), GNE(10), GNPDA1(2), GNPDA2(10), GNPNAT1(2), HEXA(3), HEXB(5), HK1(11), HK2(9), HK3(9), LHPP(2), MTMR1(16), MTMR2(5), MTMR6(10), NAGK(2), NANS(7), NPL(7), PGM3(3), PHPT1(1), RENBP(4), UAP1(6)	10429868	176	52	174	52	54	57	36	1	28	0	0.258	1.000	1.000
425	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(7), CS(6), DLAT(3), DLD(5), DLST(8), FH(8), IDH2(5), IDH3A(3), IDH3B(3), IDH3G(9), MDH1(2), MDH2(4), OGDH(13), PC(12), PDHA1(7), PDHA2(9), PDHB(3), PDHX(11), PDK1(2), PDK2(4), PDK3(12), PDK4(10), PDP2(4), SDHA(14), SDHB(2), SDHC(2), SDHD(3), SUCLA2(5), SUCLG1(5), SUCLG2(10)	10367375	191	52	189	65	67	68	30	2	24	0	0.408	1.000	1.000
426	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(7), CARS(8), DARS(7), EPRS(15), FARS2(2), GARS(8), HARS(5), IARS(8), KARS(5), LARS(18), LARS2(8), MARS(11), MARS2(4), NARS(10), QARS(7), RARS(13), SARS(4), TARS(9), WARS(6), WARS2(3), YARS(5)	11765558	163	51	160	60	42	65	30	1	25	0	0.901	1.000	1.000
427	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(5), CREB1(5), CREBBP(32), EP300(32), NCOA3(10), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), RARA(2), RXRA(3)	7436105	116	51	111	32	30	35	23	3	23	2	0.166	1.000	1.000
428	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(20), GABBR1(11), GPRC5A(7), GPRC5B(6), GPRC5C(3), GPRC5D(4), GRM1(26), GRM2(9), GRM3(18), GRM4(11), GRM5(26), GRM7(19), GRM8(19)	7056881	179	51	171	68	58	64	31	3	20	3	0.371	1.000	1.000
429	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOA(5), ALDOB(9), ALDOC(3), DERA(8), FBP1(2), FBP2(1), G6PD(6), GPI(7), H6PD(7), PFKL(8), PFKM(8), PFKP(8), PGD(3), PGLS(2), PGM1(6), PGM3(3), PRPS1(2), PRPS1L1(5), PRPS2(4), RBKS(1), RPE(5), RPIA(9), TALDO1(6), TKT(6), TKTL1(9), TKTL2(16)	8567433	149	51	143	48	60	47	19	0	23	0	0.136	1.000	1.000
430	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	37	ACAA1(5), ACAA2(3), ACAD8(5), ACAD9(8), ADH1A(2), ADH1B(5), ADH4(4), ADH6(9), ADH7(4), ADHFE1(5), AKR1B10(4), AKR1C4(6), AKR1D1(8), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(4), ALDH3A2(3), ALDH7A1(1), ALDH9A1(2), BAAT(7), CEL(5), CYP27A1(9), CYP7A1(11), HADHB(4), HSD3B7(5), LIPA(8), RDH11(1), RDH12(5), RDH13(4), RDH14(2), SLC27A5(3), SOAT1(9), SOAT2(5), SRD5A1(4)	11346074	177	51	174	66	62	57	31	4	22	1	0.546	1.000	1.000
431	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	25	ALDH1A3(8), ALDH3A1(4), ALDH3B2(7), AOC2(7), AOC3(10), DDC(8), EPX(15), ESCO1(16), ESCO2(8), GOT1(9), GOT2(3), HPD(2), LPO(6), MAOA(12), MAOB(7), MPO(8), NAT6(1), PNPLA3(7), PRDX6(4), SH3GLB1(7), TAT(7), TPO(14)	12074023	170	51	166	56	56	60	31	3	20	0	0.371	1.000	1.000
432	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(16), AP2A1(7), AP2M1(6), BIN1(3), CALM1(2), CALM2(3), DNM1(4), EPN1(8), EPS15(11), NME1(2), NME2(3), PICALM(11), PPP3CA(4), PPP3CB(6), PPP3CC(6), SYNJ1(29), SYNJ2(11), SYT1(4)	8178295	136	51	132	51	45	43	25	0	23	0	0.633	1.000	1.000
433	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	ATF1(6), CASP2(6), CHUK(8), CRADD(3), IKBKB(13), IKBKG(3), JUN(1), LTA(3), MAP2K3(7), MAP2K4(9), MAP2K6(10), MAP3K1(30), MAP4K2(5), MAPK14(4), MAPK8(11), NFKB1(10), NFKBIA(3), RELA(6), RIPK1(8), TANK(4), TNFRSF1A(4), TRAF2(3)	8545840	157	51	155	42	31	59	30	0	36	1	0.196	1.000	1.000
434	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(21), CD3D(6), CD3E(2), CD3G(3), CD4(6), CREBBP(32), CSK(1), GNAS(24), GNB1(2), GNGT1(1), HLA-DRA(1), LCK(4), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PTPRC(17), ZAP70(8)	7957941	155	50	149	51	55	50	24	1	23	2	0.301	1.000	1.000
435	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(21), CD3D(6), CD3E(2), CD3G(3), CD4(6), CREBBP(32), CSK(1), GNAS(24), GNB1(2), GNGT1(1), HLA-DRA(1), LCK(4), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PTPRC(17), ZAP70(8)	7957941	155	50	149	51	55	50	24	1	23	2	0.301	1.000	1.000
436	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(3), ACP2(1), ACP5(5), ACPP(6), ACPT(5), ALPI(4), ALPL(5), ALPP(3), ALPPL2(3), CYP19A1(13), CYP1A1(11), CYP1A2(11), CYP2A13(9), CYP2A6(13), CYP2A7(6), CYP2B6(14), CYP2C18(5), CYP2C19(6), CYP2C8(7), CYP2C9(5), CYP2D6(2), CYP2E1(2), CYP2F1(4), CYP2J2(5), CYP3A4(10), CYP3A5(6), CYP3A7(5), CYP4B1(4), CYP51A1(4), PON1(12)	10550838	189	50	185	65	57	71	35	1	23	2	0.422	1.000	1.000
437	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(5), CAPN1(5), CAPN2(11), CAPNS1(2), CAPNS2(3), CXCR3(5), EGF(19), EGFR(12), HRAS(1), ITGA1(17), ITGB1(8), MAPK1(2), MAPK3(3), MYL2(2), MYLK(14), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PTK2(12), PXN(6), TLN1(23)	12110743	177	50	174	56	64	52	34	1	25	1	0.176	1.000	1.000
438	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM1(2), CALM2(3), DLG4(10), GRIN1(4), GRIN2A(25), GRIN2B(25), GRIN2C(6), GRIN2D(5), NOS1(18), PPP3CA(4), PPP3CB(6), PPP3CC(6), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PRKCA(11), SYT1(4)	9115431	156	50	153	73	53	50	32	1	19	1	0.941	1.000	1.000
439	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CHUK(8), CREBBP(32), EP300(32), FADD(1), HDAC3(12), IKBKB(13), IKBKG(3), NFKB1(10), NFKBIA(3), RELA(6), RIPK1(8), TNFRSF1A(4), TNFRSF1B(2), TRAF6(7)	7984364	141	50	135	36	39	42	29	1	29	1	0.106	1.000	1.000
440	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(5), ACTN1(9), ACTN2(16), CAPN1(5), CAPNS1(2), CAPNS2(3), ITGA1(17), ITGB1(8), ITGB3(11), PTK2(12), PXN(6), RAC1(1), SPTAN1(31), SRC(3), TLN1(23)	10471567	152	50	149	56	60	44	21	1	26	0	0.621	1.000	1.000
441	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(17), ACO2(7), CS(6), DLD(5), DLST(8), FH(8), IDH1(4), IDH2(5), IDH3A(3), IDH3B(3), IDH3G(9), MDH1(2), MDH2(4), PC(12), PCK1(9), SDHA(14), SDHB(2), SUCLA2(5), SUCLG1(5), SUCLG2(10)	7507343	138	49	137	53	58	43	21	2	14	0	0.564	1.000	1.000
442	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAD(3), ALAS1(8), ALAS2(10), BLVRA(1), BLVRB(1), COX10(3), COX15(3), CP(13), CPOX(6), EARS2(5), EPRS(15), FECH(7), FTH1(2), FTMT(7), GUSB(5), HCCS(1), HMBS(8), HMOX1(4), HMOX2(3), MMAB(2), UGT1A1(11), UGT1A10(7), UGT1A3(2), UGT1A4(3), UGT1A5(7), UGT1A6(5), UGT1A7(7), UGT1A9(3), UGT2A1(9), UGT2A3(5), UGT2B10(18), UGT2B11(8), UGT2B15(9), UGT2B17(7), UGT2B28(15), UGT2B4(11), UGT2B7(5), UROD(3), UROS(3)	15055211	245	49	233	67	66	105	43	2	29	0	0.127	1.000	1.000
443	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(14), ACE2(22), AGT(8), AGTR1(4), AGTR2(11), ANPEP(15), CMA1(2), CPA3(5), CTSA(9), CTSG(3), ENPEP(19), LNPEP(10), MAS1(3), MME(11), NLN(3), REN(4), THOP1(3)	7592031	146	49	142	51	33	60	32	2	18	1	0.540	1.000	1.000
444	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(8), BAIAP2(5), CASP1(8), CASP3(4), CASP7(1), CASP8(21), GAPDH(2), INS(1), INSR(18), ITCH(10), MAGI1(22), MAGI2(28), RERE(19), WWP1(19), WWP2(9)	8511067	175	49	169	52	53	58	33	1	28	2	0.309	1.000	1.000
445	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(7), ABAT(9), ACADS(3), ACAT1(6), ACAT2(4), ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(4), ALDH3A2(3), ALDH5A1(7), ALDH9A1(2), ECHS1(3), EHHADH(10), GAD1(6), GAD2(12), HADHA(5), HMGCL(2), L2HGDH(5), OXCT1(10), PDHA1(7), PDHA2(9), PDHB(3), SDHB(2), SDS(1)	9314002	158	48	154	49	45	54	32	3	24	0	0.205	1.000	1.000
446	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(5), GALNS(4), GLB1(6), GNS(5), GUSB(5), HEXA(3), HEXB(5), HGSNAT(10), HPSE(6), HPSE2(11), HYAL1(2), HYAL2(4), IDS(8), IDUA(5), LCT(32), NAGLU(3), SPAM1(15)	7347340	129	48	129	52	28	57	26	2	16	0	0.871	1.000	1.000
447	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT2(2), AGPAT3(4), AGPAT4(5), AGPAT6(6), AGPS(8), CHPT1(1), ENPP2(22), ENPP6(11), PAFAH1B1(3), PAFAH1B2(3), PAFAH2(2), PLA2G12A(1), PLA2G12B(4), PLA2G2D(2), PLA2G2E(5), PLA2G2F(3), PLA2G3(7), PLA2G4A(13), PLA2G5(1), PLA2G6(9), PLD1(13), PLD2(10), PPAP2A(5), PPAP2B(3), PPAP2C(1)	8426272	144	48	139	43	45	51	19	3	25	1	0.245	1.000	1.000
448	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BAG4(5), BIRC2(10), BIRC3(5), CASP3(4), CASP8(21), CFLAR(2), FADD(1), IKBKG(3), JUN(1), MAP2K4(9), MAP3K3(8), MAP3K7(9), NFKB1(10), NFKB2(9), NFKBIA(3), NFKBIB(1), NFKBIE(6), NFKBIL1(1), NR2C2(7), RALBP1(6), RIPK1(8), TNFAIP3(3), TNFRSF1A(4), TNFRSF1B(2), TRAF2(3)	9349804	141	48	138	39	35	55	23	0	26	2	0.212	1.000	1.000
449	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	29	AKR1C4(6), AKR1D1(8), ARSB(5), ARSD(5), ARSE(10), CYP11B1(8), CYP11B2(8), HSD11B1(6), HSD17B2(2), HSD17B3(7), HSD17B8(2), HSD3B1(3), HSD3B2(6), SRD5A1(4), STS(8), SULT1E1(9), SULT2A1(7), UGT1A1(11), UGT1A10(7), UGT1A3(2), UGT1A4(3), UGT1A5(7), UGT1A6(5), UGT1A7(7), UGT1A9(3), UGT2B15(9), UGT2B4(11)	9754557	169	47	163	57	45	79	25	2	18	0	0.411	1.000	1.000
450	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	22	ARSA(3), ARSB(5), ARSD(5), ARSE(10), ASAH1(6), GAL3ST1(7), GALC(8), GBA(4), GLA(9), GLB1(6), LCT(32), NEU2(4), NEU3(3), PPAP2A(5), PPAP2B(3), PPAP2C(1), SMPD1(4), SMPD2(6), SPTLC1(5), SPTLC2(5), UGCG(4)	8264638	135	47	133	43	33	65	23	1	13	0	0.312	1.000	1.000
451	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ACY1(3), AGMAT(3), ALDH18A1(9), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(4), ALDH3A2(3), ALDH7A1(1), ALDH9A1(2), AMD1(3), AOC2(7), AOC3(10), ARG1(5), ARG2(3), ASL(2), ASS1(1), CPS1(22), GATM(5), MAOA(12), MAOB(7), NAGS(3), ODC1(2), OTC(7), SAT1(5), SAT2(1), SMS(8), SRM(1)	10557702	146	47	143	60	46	52	26	3	17	2	0.848	1.000	1.000
452	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(6), CARM1(5), CBS(11), CTH(6), GGT1(5), HEMK1(2), LCMT1(2), LCMT2(9), MARS(11), MARS2(4), MAT1A(4), MAT2B(10), METTL2B(4), METTL6(4), PAPSS1(8), PAPSS2(7), PRMT2(1), PRMT3(8), PRMT5(10), PRMT6(5), PRMT7(5), PRMT8(7), SCLY(3), SEPHS1(12), SEPHS2(5), WBSCR22(2)	8840900	156	47	152	53	55	58	16	2	25	0	0.322	1.000	1.000
453	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(1), ALDOA(5), ALDOB(9), ALDOC(3), FBP1(2), FBP2(1), FPGT(6), GCK(2), GMDS(4), GMPPA(4), GMPPB(2), HK1(11), HK2(9), HK3(9), KHK(2), MPI(5), PFKFB1(8), PFKFB3(4), PFKFB4(4), PFKM(8), PFKP(8), PMM2(6), SORD(5), TPI1(2)	8759023	120	46	118	60	46	33	22	0	19	0	0.969	1.000	1.000
454	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	26	ACAA1(5), ACAA2(3), ADH1A(2), ADH1B(5), ADH4(4), ADH6(9), ADH7(4), ADHFE1(5), AKR1C4(6), AKR1D1(8), ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(4), ALDH3A2(3), ALDH9A1(2), BAAT(7), CEL(5), CYP27A1(9), CYP7A1(11), HADHB(4), SOAT2(5), SRD5A1(4)	8301184	143	45	140	51	49	45	28	3	18	0	0.436	1.000	1.000
455	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOA(5), ALDOB(9), ALDOC(3), FBP1(2), FBP2(1), GOT1(9), GOT2(3), GPT(2), GPT2(5), MDH1(2), MDH2(4), ME1(12), ME2(8), ME3(9), PGK1(7), PKLR(6), RPE(5), RPIA(9), TKT(6), TPI1(2)	6427743	109	45	107	32	32	45	19	2	11	0	0.160	1.000	1.000
456	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(9), AGT(8), AGTR2(11), EDN1(4), EDNRA(5), EDNRB(4), EGF(19), EGFR(12), FOS(3), HRAS(1), JUN(1), MYC(8), NFKB1(10), PLCG1(12), PRKCA(11), RELA(6)	7459154	124	45	120	46	30	47	31	2	14	0	0.706	1.000	1.000
457	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(4), POLD1(10), POLD2(6), POLE(47), POLG(6), POLL(6), POLQ(29)	6044414	108	45	95	31	31	56	14	1	6	0	0.249	1.000	1.000
458	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	36	ANPEP(15), G6PD(6), GCLC(8), GCLM(2), GGT1(5), GPX2(1), GPX5(6), GPX6(7), GPX7(1), GSR(6), GSS(5), GSTA1(2), GSTA2(6), GSTA3(5), GSTA4(3), GSTA5(4), GSTK1(5), GSTM1(2), GSTM2(3), GSTM3(5), GSTM4(1), GSTM5(1), GSTO2(1), GSTP1(2), GSTT1(1), GSTT2(1), GSTZ1(5), IDH1(4), IDH2(5), MGST1(4), MGST3(2), TXNDC12(5)	7340923	129	45	125	41	39	44	30	1	14	1	0.294	1.000	1.000
459	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	14	AGA(7), FUCA1(3), FUCA2(4), GLB1(6), HEXA(3), HEXB(5), LCT(32), MAN2B1(14), MAN2B2(5), MAN2C1(7), MANBA(12), NEU2(4), NEU3(3)	6888206	105	45	104	41	29	40	22	3	11	0	0.778	1.000	1.000
460	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(15), POLR1B(16), POLR1C(2), POLR1D(3), POLR2A(21), POLR2B(21), POLR2C(5), POLR2D(3), POLR2E(1), POLR2F(1), POLR2H(3), POLR2J(1), POLR2K(2), POLR3A(7), POLR3B(14), POLR3G(3), POLR3GL(2), POLR3H(4)	8487029	124	45	123	37	43	42	17	2	19	1	0.284	1.000	1.000
461	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(8), CHUK(8), IFNG(10), IKBKB(13), IL2(2), IL4(1), JUN(1), MAP3K1(30), MAP3K5(25), MAP4K5(7), MAPK14(4), MAPK8(11), NFKB1(10), NFKBIA(3), RELA(6), TNFRSF9(2), TNFSF9(6), TRAF2(3)	7209024	150	44	146	40	39	62	19	1	28	1	0.222	1.000	1.000
462	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCR3(4), CFL1(1), GNAQ(3), GNAS(24), GNB1(2), GNGT1(1), HRAS(1), LIMK1(8), MAP2K1(2), MAPK1(2), MAPK3(3), MYL2(2), NOX1(16), PIK3C2G(16), PLCB1(5), PPP1R12B(19), PRKCA(11), PTK2(12), RAF1(9), ROCK2(17)	9254834	158	44	153	46	49	47	32	3	27	0	0.391	1.000	1.000
463	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(5), CALCR(9), CALCRL(8), CD97(13), CRHR1(3), CRHR2(2), ELTD1(12), EMR1(17), EMR2(4), GHRHR(2), GIPR(5), GLP1R(5), GLP2R(11), GPR64(11), LPHN1(17), LPHN2(22), LPHN3(21), SCTR(5), VIPR1(3), VIPR2(4)	10055000	179	44	174	70	53	71	27	1	25	2	0.607	1.000	1.000
464	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(6), AMD1(3), BHMT(2), CBS(11), CTH(6), DNMT1(14), DNMT3A(8), DNMT3B(15), MARS(11), MARS2(4), MAT1A(4), MAT2B(10), MTAP(4), MTR(11), SRM(1), TAT(7)	7468924	117	44	114	51	46	37	19	1	14	0	0.861	1.000	1.000
465	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(5), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(4), ALDH3A2(3), ALDH7A1(1), ALDH9A1(2), CYP2C19(6), CYP2C9(5), DHRS1(3), DHRS2(3), DHRS3(2), DHRS7(6), DHRSX(2), ECHS1(3), EHHADH(10), ESCO1(16), ESCO2(8), HADHA(5), NAT6(1), PNPLA3(7), SH3GLB1(7), YOD1(2)	11203507	118	44	117	43	37	47	19	2	13	0	0.683	1.000	1.000
466	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(2), ASNS(9), CA1(6), CA12(1), CA13(4), CA14(4), CA2(2), CA3(5), CA4(1), CA5A(6), CA5B(7), CA6(2), CA7(5), CA8(6), CA9(4), CPS1(22), CTH(6), GLS(11), GLS2(7), GLUD1(3), GLUD2(9), GLUL(7), HAL(6)	7721466	135	44	130	46	39	52	17	2	23	2	0.554	1.000	1.000
467	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	CHUK(8), FADD(1), IKBKB(13), IKBKG(3), IL1R1(5), IRAK1(4), MAP3K1(30), MAP3K7(9), MYD88(2), NFKB1(10), NFKBIA(3), RELA(6), RIPK1(8), TLR4(17), TNFAIP3(3), TNFRSF1A(4), TNFRSF1B(2), TRAF6(7)	8589976	135	44	134	32	29	53	24	0	27	2	0.109	1.000	1.000
468	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCL4(5), CCR1(4), CCR2(5), CCR3(4), CCR4(5), CCR5(6), CCR7(6), CD28(3), CD4(6), CSF2(1), CXCR3(5), CXCR4(1), IFNG(10), IFNGR1(4), IFNGR2(4), IL12A(5), IL12B(2), IL12RB1(13), IL12RB2(10), IL18R1(9), IL2(2), IL4(1), IL4R(6), IL5(2), TGFB1(1), TGFB2(5), TGFB3(9)	7439499	134	44	133	42	37	52	23	1	21	0	0.249	1.000	1.000
469	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	21	ALDH1A3(8), ALDH3A1(4), ALDH3B2(7), AOC2(7), AOC3(10), DDC(8), EPX(15), GOT1(9), GOT2(3), HPD(2), LPO(6), MAOA(12), MAOB(7), MPO(8), PRDX2(2), PRDX5(1), PRDX6(4), TAT(7), TPO(14)	7660602	134	44	130	48	46	45	25	3	15	0	0.435	1.000	1.000
470	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(21), ADRB2(7), GNAS(24), PLCE1(39), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3)	5147041	118	44	114	34	44	28	27	1	17	1	0.186	1.000	1.000
471	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(12), DYRK1B(4), GLI2(10), GLI3(28), GSK3B(13), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), SHH(4), SMO(9), SUFU(3)	5610085	110	44	107	55	40	38	12	3	15	2	0.903	1.000	1.000
472	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(17), BIRC2(10), BIRC3(5), CASP10(8), CASP3(4), CASP7(1), CASP8(21), CASP9(3), DFFB(4), GZMB(4), PRF1(8), SCAP(11), SREBF1(2), SREBF2(13)	6378058	111	43	106	38	30	43	15	0	23	0	0.596	1.000	1.000
473	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(7), CYB5R3(4), GCK(2), GFPT1(9), GNE(10), GNPDA1(2), GNPDA2(10), HEXA(3), HEXB(5), HK1(11), HK2(9), HK3(9), PGM3(3), RENBP(4), UAP1(6)	6187133	94	42	93	34	32	24	21	1	16	0	0.702	1.000	1.000
474	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(5), EPHA4(19), EPHB1(26), FYN(5), ITGA1(17), ITGB1(8), L1CAM(20), LYN(9), RAP1B(2), SELP(13)	5796064	124	42	121	38	38	46	21	1	18	0	0.206	1.000	1.000
475	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(3), B4GALNT1(6), GLB1(6), HEXA(3), HEXB(5), LCT(32), SLC33A1(9), ST3GAL1(2), ST3GAL2(6), ST3GAL5(4), ST6GALNAC3(8), ST6GALNAC4(4), ST6GALNAC5(2), ST6GALNAC6(6), ST8SIA1(2), ST8SIA5(8)	5831166	106	42	104	40	30	42	18	2	14	0	0.654	1.000	1.000
476	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	66	MRPS7(3), RPL10A(1), RPL10L(8), RPL11(3), RPL13(1), RPL13A(1), RPL14(2), RPL18(1), RPL18A(2), RPL19(4), RPL21(3), RPL22L1(4), RPL23A(4), RPL24(2), RPL27(1), RPL27A(3), RPL28(2), RPL29(2), RPL3(2), RPL34(1), RPL35A(2), RPL36AL(1), RPL37(2), RPL37A(1), RPL38(1), RPL39(4), RPL3L(3), RPL6(3), RPL7(1), RPL8(2), RPL9(2), RPS10(1), RPS11(1), RPS12(2), RPS13(1), RPS15A(1), RPS16(1), RPS18(3), RPS2(1), RPS20(3), RPS21(1), RPS24(2), RPS25(2), RPS27(1), RPS28(1), RPS29(2), RPS3(3), RPS3A(1), RPS6(7), RPS7(5), RPS8(2), RPSA(1)	8167792	114	42	111	38	34	46	24	2	8	0	0.764	1.000	1.000
477	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(19), CALM1(2), CALM2(3), CAPN2(11), CAPNS1(2), CAPNS2(3), EP300(32), HDAC1(5), HDAC2(3), MEF2D(7), NFATC1(10), NFATC2(13), PPP3CA(4), PPP3CB(6), PPP3CC(6), PRKCA(11), SYT1(4)	8576701	141	42	136	40	51	31	31	1	27	0	0.160	1.000	1.000
478	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(5), ADCY1(21), CAP1(4), CCNB1(8), CDC25C(5), GNAI1(5), GNAS(24), GNB1(2), GNGT1(1), HRAS(1), MAPK1(2), MAPK3(3), MYT1(18), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), RPS6KA1(1), SRC(3)	7150582	130	42	126	40	50	39	23	1	16	1	0.171	1.000	1.000
479	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(5), ALDOB(9), ALDOC(3), FBP1(2), FBP2(1), G6PD(6), GPI(7), H6PD(7), PFKM(8), PFKP(8), PGD(3), PGLS(2), PGM1(6), PGM3(3), PRPS1(2), PRPS1L1(5), PRPS2(4), RBKS(1), RPE(5), RPIA(9), TAL1(1), TALDO1(6), TKT(6)	7121683	109	42	106	40	40	36	17	0	16	0	0.437	1.000	1.000
480	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	18	CHUK(8), DUSP1(2), IKBKAP(13), IKBKB(13), IKBKG(3), LTA(3), MAP3K1(30), NFKB1(10), NFKBIA(3), RELA(6), RIPK1(8), TANK(4), TNFAIP3(3), TNFRSF1B(2), TRAF1(5), TRAF2(3), TRAF3(5)	8209617	121	42	120	32	28	50	16	0	26	1	0.171	1.000	1.000
481	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(12), CSF1R(8), EGF(19), EGFR(12), GRB2(3), MET(17), PDGFRA(24), PRKCA(11), SH3GLB1(7), SH3GLB2(6), SH3KBP1(7), SRC(3)	7155198	129	41	126	42	33	44	32	0	18	2	0.358	1.000	1.000
482	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(12), F2(8), F2R(6), F3(5), F5(47), F7(2), FGA(26), FGB(7), FGG(9), PROC(4), PROS1(21), SERPINC1(10), TFPI(8)	5927459	165	41	157	42	34	83	31	1	14	2	0.139	1.000	1.000
483	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(12), EXT2(6), EXTL1(9), EXTL2(8), EXTL3(10), GLCE(5), HS2ST1(7), HS3ST1(5), HS3ST2(5), HS3ST3A1(2), HS3ST3B1(5), HS3ST5(9), HS6ST1(2), HS6ST2(9), HS6ST3(3), NDST1(14), NDST2(9), NDST3(14), NDST4(15)	7439901	149	41	147	48	40	58	32	1	17	1	0.370	1.000	1.000
484	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(4), GRB2(3), IL2RG(11), IL4(1), IL4R(6), IRS1(13), JAK1(20), JAK3(10), RPS6KB1(3), SHC1(6), STAT6(10)	5172677	87	41	87	29	25	31	16	1	14	0	0.478	1.000	1.000
485	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(6), BHMT(2), CBS(11), CTH(6), DNMT1(14), DNMT3A(8), DNMT3B(15), MARS(11), MARS2(4), MAT1A(4), MAT2B(10), MTR(11)	6295427	102	41	99	42	41	31	15	1	14	0	0.750	1.000	1.000
486	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(21), ARHGEF1(12), GNA12(7), GNA13(7), GNAQ(3), GNB1(2), GNGT1(1), MYL2(2), MYLK(14), PLCB1(5), PPP1R12B(19), PRKCA(11), ROCK1(22)	7598901	126	41	122	47	43	40	26	2	11	4	0.777	1.000	1.000
487	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(2), ASNS(9), CA1(6), CA12(1), CA14(4), CA2(2), CA3(5), CA4(1), CA5A(6), CA5B(7), CA6(2), CA7(5), CA8(6), CA9(4), CPS1(22), CTH(6), GLS(11), GLS2(7), GLUD1(3), GLUL(7), HAL(6)	6927980	122	41	117	36	33	48	16	2	21	2	0.304	1.000	1.000
488	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(11), GTF2A1(3), GTF2B(5), GTF2E1(3), GTF2F1(7), HDAC3(12), NCOA1(19), NCOA2(15), NCOA3(10), NCOR2(24), POLR2A(21), RARA(2), RXRA(3), TBP(3)	8960600	138	41	135	45	53	40	26	1	18	0	0.378	1.000	1.000
489	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(17), ARHGDIB(3), BIRC2(10), BIRC3(5), CASP1(8), CASP10(8), CASP2(6), CASP3(4), CASP4(5), CASP6(7), CASP7(1), CASP8(21), CASP9(3), CYCS(2), DFFB(4), GZMB(4), LMNA(7), LMNB1(5), LMNB2(4), PRF1(8)	6936180	132	40	126	40	35	49	20	1	27	0	0.509	1.000	1.000
490	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QA(4), C1QB(3), C1R(11), C1S(8), C2(2), C3(22), C5(18), C6(16), C7(20), C8A(9), C9(19), MASP1(13), MASP2(7), MBL2(4)	7752035	156	40	149	50	34	74	30	0	16	2	0.420	1.000	1.000
491	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(15), CD2(4), CD33(6), CD5(10), CD7(3), CSF2(1), IFNA1(2), IFNB1(3), IFNG(10), IL10(4), IL12A(5), IL12B(2), IL3(2), IL4(1), IL5(2), ITGAX(14), TLR2(16), TLR4(17), TLR7(17), TLR9(6)	6754142	140	40	138	43	41	58	19	1	19	2	0.119	1.000	1.000
492	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(17), ACO2(7), AFMID(6), CS(6), GRHPR(2), HAO1(3), HAO2(10), HYI(2), MDH1(2), MDH2(4), MTHFD1(7), MTHFD1L(15), MTHFD2(4)	4944780	85	40	84	29	35	23	18	0	9	0	0.344	1.000	1.000
493	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	12	AGA(7), FUCA1(3), FUCA2(4), GLB1(6), HEXA(3), HEXB(5), LCT(32), MAN2C1(7), MANBA(12), NEU2(4), NEU3(3)	5549271	86	40	85	32	19	32	22	2	11	0	0.788	1.000	1.000
494	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(3), BLVRA(1), BLVRB(1), CP(13), CPOX(6), EPRS(15), FECH(7), GUSB(5), HCCS(1), HMBS(8), HMOX1(4), HMOX2(3), UGT1A1(11), UGT1A10(7), UGT1A3(2), UGT1A4(3), UGT1A5(7), UGT1A6(5), UGT1A7(7), UGT1A9(3), UGT2B15(9), UGT2B4(11), UROD(3), UROS(3)	10003330	138	40	133	44	42	61	20	1	14	0	0.470	1.000	1.000
495	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	12	CNR1(11), CNR2(6), DNMT1(14), MTNR1A(5), MTNR1B(4), PTAFR(4), PTGDR(9), PTGER2(3), PTGER4(12), PTGFR(10), PTGIR(3)	3658357	81	40	79	29	31	30	16	0	4	0	0.277	1.000	1.000
496	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QA(4), C1QB(3), C1R(11), C1S(8), C2(2), C3(22), C5(18), C6(16), C7(20), C8A(9), C8B(5), C9(19), MASP1(13)	7552563	150	39	142	47	33	67	31	0	17	2	0.386	1.000	1.000
497	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	31	ANPEP(15), G6PD(6), GCLC(8), GCLM(2), GGT1(5), GPX2(1), GPX5(6), GSS(5), GSTA1(2), GSTA2(6), GSTA3(5), GSTA4(3), GSTM1(2), GSTM2(3), GSTM3(5), GSTM4(1), GSTM5(1), GSTO2(1), GSTP1(2), GSTT1(1), GSTT2(1), GSTZ1(5), IDH1(4), IDH2(5), MGST1(4), MGST3(2), PGD(3)	6581275	104	39	101	33	29	39	25	1	9	1	0.333	1.000	1.000
498	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(31), ACACB(29), FASN(9), MCAT(3), OLAH(4), OXSM(6)	5404313	82	39	79	35	31	22	15	2	9	3	0.770	1.000	1.000
499	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	21	AOX1(18), BST1(1), CD38(6), ENPP1(12), ENPP3(17), NADK(7), NADSYN1(6), NMNAT1(3), NMNAT2(3), NMNAT3(1), NNMT(6), NNT(7), NT5C(1), NT5C1A(2), NT5C1B(8), NT5C2(6), NT5E(6), NT5M(2), NUDT12(4), QPRT(2)	7699061	118	39	116	38	37	42	33	0	6	0	0.339	1.000	1.000
500	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG12(1), ATG3(2), ATG5(3), ATG7(5), BECN1(1), GABARAP(1), GABARAPL1(3), IFNA1(2), IFNA10(3), IFNA13(3), IFNA14(4), IFNA16(3), IFNA17(3), IFNA2(2), IFNA21(1), IFNA4(3), IFNA5(5), IFNA6(2), IFNA7(1), IFNA8(3), IFNG(10), INS(1), PIK3C3(14), PIK3R4(21), PRKAA1(8), PRKAA2(11), ULK1(5), ULK2(11), ULK3(5)	7623927	137	39	136	38	29	64	24	0	19	1	0.366	1.000	1.000
501	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(14), ABCC2(30), ABCG2(16), BCHE(17), CES1(13), CES2(2), CYP3A4(10), CYP3A5(6), UGT1A1(11), UGT1A10(7), UGT1A3(2), UGT1A4(3), UGT1A5(7), UGT1A6(5), UGT1A7(7), UGT1A9(3)	8435358	153	39	149	44	35	65	40	0	11	2	0.152	1.000	1.000
502	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(8), F2R(6), GNAI1(5), GNB1(2), GNGT1(1), HRAS(1), ITGA1(17), ITGB1(8), MAP2K1(2), MAPK1(2), MAPK3(3), PLA2G4A(13), PLCB1(5), PRKCA(11), PTGS1(5), PTK2(12), RAF1(9), SRC(3), SYK(4), TBXAS1(7)	8821295	124	39	123	45	29	44	27	4	20	0	0.695	1.000	1.000
503	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM1(2), CALM2(3), CCL4(5), CCR5(6), CXCL12(3), CXCR4(1), FOS(3), GNAQ(3), JUN(1), MAPK14(4), MAPK8(11), PLCG1(12), PRKCA(11), PTK2B(15), SYT1(4)	4962945	84	38	82	32	25	29	18	0	12	0	0.681	1.000	1.000
504	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(21), GNAS(24), GNB1(2), GNGT1(1), PPP2CA(6), PRKAA1(8), PRKAA2(11), PRKAB1(6), PRKAB2(1), PRKACB(3), PRKACG(9), PRKAG1(3), PRKAG2(4), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3)	5373906	114	38	110	35	47	32	16	2	16	1	0.276	1.000	1.000
505	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(19), EGFR(12), MAP2K1(2), MAP3K1(30), MAPK14(4), NCOR2(24), RARA(2), RXRA(3), THRA(4), THRB(4)	6019780	104	38	102	36	29	32	21	1	20	1	0.610	1.000	1.000
506	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(4), GABARAP(1), GABRA1(14), GABRA2(13), GABRA3(14), GABRA4(19), GABRA5(10), GABRA6(8), GPHN(17), NSF(3), SRC(3), UBQLN1(6)	4390786	112	38	106	31	31	47	20	0	14	0	0.193	1.000	1.000
507	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(5), GALNS(4), GLB1(6), GNS(5), GUSB(5), HEXA(3), HEXB(5), IDS(8), IDUA(5), LCT(32), NAGLU(3)	5119464	81	38	81	34	19	33	18	2	9	0	0.832	1.000	1.000
508	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	23	ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(4), ALDH3A2(3), ALDH3B2(7), ALDH9A1(2), AOC2(7), AOC3(10), ASPA(5), CNDP1(4), DDC(8), HAL(6), HARS(5), HDC(9), HNMT(2), MAOA(12), MAOB(7), PRPS1(2), PRPS2(4)	8613975	135	38	130	45	42	46	27	2	18	0	0.361	1.000	1.000
509	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	34	BET1(2), BNIP1(4), GOSR1(3), GOSR2(1), SNAP23(3), SNAP25(7), SNAP29(4), STX10(1), STX11(6), STX12(3), STX16(1), STX17(1), STX18(2), STX19(3), STX2(6), STX3(7), STX4(6), STX5(5), STX6(3), STX7(6), STX8(3), TSNARE1(3), USE1(4), VAMP1(1), VAMP3(1), VAMP4(1), VAMP5(1), VAMP7(3), VTI1A(1), VTI1B(6), YKT6(4)	5962055	102	38	98	30	33	29	19	0	21	0	0.363	1.000	1.000
510	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM1(2), CALM2(3), CAMK1(3), CAMK1G(5), CAMK2A(9), CAMK2B(4), CAMK2D(5), CAMK2G(5), CAMK4(5), ESRRA(2), HDAC5(12), MEF2A(3), MEF2B(1), MEF2C(10), MEF2D(7), PPARA(2), PPP3CA(4), PPP3CB(6), PPP3CC(6), SLC2A4(9), SYT1(4), YWHAH(3)	7515013	110	38	109	37	41	33	19	0	17	0	0.345	1.000	1.000
511	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(16), POLR2A(21), POLR2B(21), POLR2C(5), POLR2D(3), POLR2E(1), POLR2F(1), POLR2H(3), POLR2J(1), POLR2K(2), POLRMT(11)	4571137	85	38	84	25	32	26	13	0	13	1	0.307	1.000	1.000
512	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	17	CALM1(2), CALM2(3), CDKN1A(1), GNAQ(3), NFATC1(10), NFATC2(13), NFATC3(11), NFATC4(5), PLCG1(12), PPP3CA(4), PPP3CB(6), PPP3CC(6), PRKCA(11), SP1(7), SP3(10), SYT1(4)	7204844	108	37	104	42	38	32	23	0	15	0	0.735	1.000	1.000
513	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5(2), CDK5R1(3), CSNK1D(3), DRD1(6), DRD2(8), GRM1(26), PLCB1(5), PPP1CA(2), PPP1R1B(2), PPP2CA(6), PPP3CA(4), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3)	5735718	94	37	93	41	30	35	12	4	12	1	0.762	1.000	1.000
514	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(6), AOC2(7), AOC3(10), CES1(13), DDHD1(9), ESCO1(16), ESCO2(8), LIPA(8), NAT6(1), PLA1A(6), PNPLA3(7), PPME1(3), PRDX6(4), SH3GLB1(7)	9195734	105	37	102	31	27	42	21	0	14	1	0.348	1.000	1.000
515	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(4), IL22RA1(4), IL22RA2(1), JAK1(20), JAK2(17), JAK3(10), STAT1(15), STAT3(11), STAT5A(5), STAT5B(7), TYK2(10)	6607070	104	37	103	41	29	38	18	0	16	3	0.752	1.000	1.000
516	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	10	CD44(5), ICAM1(2), ITGA4(10), ITGAL(17), ITGAM(21), ITGB1(8), ITGB2(15), SELE(5), SELL(5), SELP(13)	5968706	101	37	97	34	25	40	14	0	21	1	0.419	1.000	1.000
517	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(3), ALDH18A1(9), ARG1(5), ARG2(3), ASL(2), CKM(3), CKMT1A(1), CKMT2(4), CPS1(22), GAMT(3), GATM(5), GLUD1(3), NAGS(3), OAT(7), ODC1(2), OTC(7), PYCR1(3), SMS(8)	6217565	93	37	92	38	28	32	17	2	12	2	0.882	1.000	1.000
518	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QA(4), C1QB(3), C1R(11), C1S(8), C2(2), C3(22), C5(18), C6(16), C7(20), C8A(9), C9(19)	6333689	132	36	126	43	25	60	29	0	16	2	0.539	1.000	1.000
519	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(17), ACO2(7), CS(6), GRHPR(2), HAO1(3), HAO2(10), HYI(2), MDH1(2), MDH2(4), MTHFD1(7), MTHFD1L(15), MTHFD2(4)	4710422	79	36	78	27	32	21	18	0	8	0	0.384	1.000	1.000
520	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(8), CARS2(5), CDO1(4), CTH(6), GOT1(9), GOT2(3), LDHA(6), LDHAL6A(8), LDHAL6B(2), LDHB(3), LDHC(5), MPST(1), SDS(1), SULT1B1(7), SULT1C2(4), SULT1C4(4), SULT4A1(4)	4529700	80	36	77	30	17	30	18	2	13	0	0.811	1.000	1.000
521	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ATP6V0C(1), CAT(4), EPX(15), LPO(6), MPO(8), PRDX2(2), PRDX5(1), PRDX6(4), SHMT1(5), SHMT2(5), TPO(14)	4251973	65	36	63	29	27	22	8	1	7	0	0.824	1.000	1.000
522	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(11), ESR2(5), ITPKA(1), PDE1A(14), PDE1B(7), PLCB1(5), PLCB2(8), PRL(9), TRH(1), VIP(4)	3949492	65	36	62	24	17	19	15	3	11	0	0.789	1.000	1.000
523	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(5), ACTR2(6), ACTR3(1), ARPC1A(6), ARPC1B(5), ARPC2(1), ARPC3(1), ARPC4(1), NCK1(4), NCKAP1(8), NTRK1(13), PIR(6), PSMA7(2), RAC1(1), WASF1(3), WASF2(3), WASF3(8), WASL(8)	5632560	82	35	82	27	25	36	10	0	11	0	0.503	1.000	1.000
524	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	15	GATA3(3), IL4(1), IL5(2), MAF(2), MAP2K3(7), MAPK14(4), NFATC1(10), NFATC2(13), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3)	3863826	69	35	67	30	27	18	13	1	9	1	0.602	1.000	1.000
525	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	CAT(4), EPX(15), LPO(6), MPO(8), MTHFR(9), PRDX6(4), SHMT1(5), SHMT2(5), TPO(14)	4173957	70	35	67	28	30	21	8	2	9	0	0.699	1.000	1.000
526	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(10), AMT(2), ATIC(7), ATP6V0C(1), DHFR(4), GART(9), MTHFD1(7), MTHFD1L(15), MTHFD2(4), MTHFR(9), MTR(11), SHMT1(5), SHMT2(5)	6599249	89	35	86	30	35	30	13	1	10	0	0.286	1.000	1.000
527	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(3), CD3D(6), CD3E(2), CD3G(3), IFNG(10), IL2(2), IL2RA(4), IL4(1), TGFB1(1), TGFB2(5), TGFB3(9), TGFBR1(6), TGFBR2(6), TGFBR3(15), TOB1(4), TOB2(5)	3917492	82	35	82	29	25	35	10	1	11	0	0.629	1.000	1.000
528	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP1(3), ACP2(1), ACP5(5), ACP6(4), ACPP(6), ACPT(5), ALPI(4), ALPL(5), ALPP(3), ALPPL2(3), CMBL(3), CYP3A4(10), CYP3A43(4), CYP3A5(6), CYP3A7(5), DHRS1(3), DHRS2(3), DHRS3(2), DHRS7(6), DHRSX(2), PON1(12), PON2(6), PON3(5)	6438004	106	34	104	30	24	39	26	1	16	0	0.148	1.000	1.000
529	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	15	B3GAT1(4), B3GAT2(1), B3GAT3(2), B4GALT7(4), CHPF(5), CHST11(8), CHST12(3), CHST14(3), CHST3(4), CHST7(4), CHSY1(8), DSE(22), UST(3), XYLT1(16), XYLT2(4)	4484184	91	34	90	35	36	30	21	0	4	0	0.603	1.000	1.000
530	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(10), AMT(2), ATIC(7), DHFR(4), FTCD(7), GART(9), MTHFD1(7), MTHFD1L(15), MTHFD2(4), MTHFR(9), MTR(11), SHMT1(5), SHMT2(5)	6928161	95	34	92	33	36	32	16	1	10	0	0.371	1.000	1.000
531	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(32), ABCB11(15), ABCB4(28), ABCC1(14), ABCC3(10), GSTP1(2)	5405704	101	34	98	38	19	41	24	0	13	4	0.681	1.000	1.000
532	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG5(2), B4GALT1(2), B4GALT2(5), B4GALT3(10), B4GALT5(2), DDOST(3), DPAGT1(3), DPM1(2), FUT8(10), MAN1A1(13), MAN1B1(5), MGAT1(4), MGAT2(4), MGAT3(4), MGAT4A(5), MGAT4B(6), MGAT5(11), RPN1(3), RPN2(5), ST6GAL1(7)	6843201	106	34	100	37	37	32	27	1	9	0	0.618	1.000	1.000
533	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(15), CKM(3), EIF4E(1), FBL(3), GPT(2), LDHA(6), LDHB(3), LDHC(5), MAPK14(4), NCL(7)	3281547	49	34	49	22	9	18	11	3	7	1	0.930	1.000	1.000
534	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	AANAT(2), ACHE(4), CHAT(5), COMT(3), DBH(9), DDC(8), GAD1(6), GAD2(12), HDC(9), MAOA(12), PAH(2), PNMT(2), SLC18A3(6), TH(3), TPH1(9)	4928980	92	33	90	33	28	27	19	1	15	2	0.430	1.000	1.000
535	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(11), ACO1(17), ACO2(7), ACSS1(5), ACSS2(5), FH(8), IDH1(4), IDH2(5), MDH1(2), MDH2(4), SUCLA2(5)	4873171	73	33	73	34	28	24	14	0	7	0	0.863	1.000	1.000
536	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(1), BLVRB(1), HMOX1(4), IL10(4), IL10RA(4), IL10RB(6), IL6(5), JAK1(20), STAT1(15), STAT3(11), STAT5A(5)	4358319	76	33	75	28	25	20	13	0	18	0	0.580	1.000	1.000
537	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(8), ADSS(6), DHFR(4), HPRT1(2), IMPDH1(6), MTHFD2(4), NME2(3), OAZ1(1), POLB(4), POLD1(10), POLG(6), PRPS2(4), RRM1(2), SRM(1)	4466818	61	33	60	28	21	17	12	0	11	0	0.926	1.000	1.000
538	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(6), CBS(11), CTH(6), GGT1(5), MARS(11), MARS2(4), MAT1A(4), MAT2B(10), PAPSS1(8), PAPSS2(7), SCLY(3), SEPHS1(12)	4419353	87	33	84	30	38	27	9	1	12	0	0.362	1.000	1.000
539	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(15), LPO(6), MPO(8), PRDX2(2), PRDX5(1), PRDX6(4), TPO(14), TYR(12)	3491995	62	33	60	26	21	21	13	1	6	0	0.804	1.000	1.000
540	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(15), GBA(4), LPO(6), MPO(8), PRDX6(4), TPO(14)	3039937	51	32	49	23	19	18	8	1	5	0	0.842	1.000	1.000
541	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	7	CD44(5), ICAM1(2), ITGAL(17), ITGAM(21), ITGB2(15), SELE(5), SELL(5)	3941677	70	32	69	31	19	26	9	0	15	1	0.813	1.000	1.000
542	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(4), GNAS(24), GNB1(2), GNGT1(1), PRKACB(3), PRKACG(9), PRKAR1A(4), PRKAR1B(4), PRKAR2A(4), PRKAR2B(3), PRKCA(11)	3374899	69	31	66	24	31	17	10	1	9	1	0.555	1.000	1.000
543	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(29), GNA12(7), PRKACB(3), PRKACG(9), PRKAG1(3), PRKAR2A(4), PRKAR2B(3)	3655022	58	31	56	20	15	20	13	0	9	1	0.677	1.000	1.000
544	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(5), B3GNT2(1), B3GNT7(3), B4GALT1(2), B4GALT2(5), B4GALT3(10), B4GALT4(5), CHST1(8), CHST2(2), CHST4(4), CHST6(6), FUT8(10), ST3GAL1(2), ST3GAL2(6), ST3GAL3(6), ST3GAL4(3)	4140897	78	31	76	42	38	21	13	1	5	0	0.970	1.000	1.000
545	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACAA1(5), ACOX1(7), ACOX3(8), ELOVL2(8), ELOVL5(2), ELOVL6(4), FADS1(4), FADS2(2), FASN(9), HADHA(5), HSD17B12(4), PECR(6), SCD(6)	4854200	70	31	70	28	26	21	12	0	11	0	0.568	1.000	1.000
546	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(4), PSMA2(4), PSMA3(5), PSMA4(2), PSMA5(2), PSMA6(1), PSMA7(2), PSMB1(2), PSMB2(2), PSMB3(2), PSMB4(1), PSMB5(3), PSMB6(4), PSMB7(2), PSMC2(3), PSMC3(1), PSMD1(12), PSMD11(6), PSMD12(5), PSMD13(1), PSMD2(11), PSMD6(2)	5921391	77	31	73	24	21	25	12	0	19	0	0.545	1.000	1.000
547	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(20), JAK2(17), JAK3(10), MAPK1(2), MAPK3(3), STAT3(11), TYK2(10)	4165944	73	31	73	26	16	25	15	0	14	3	0.654	1.000	1.000
548	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	CYP51A1(4), DHCR7(2), FDFT1(1), FDPS(8), HMGCR(12), HMGCS1(6), IDI1(3), LSS(6), MVD(3), MVK(3), NSDHL(10), PMVK(3), SQLE(5)	4725661	66	30	65	30	18	24	17	0	7	0	0.922	1.000	1.000
549	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(11), ERBB4(27), NRG2(4), NRG3(15), PRKCA(11), PSEN1(5)	3322589	73	30	72	26	23	25	14	0	10	1	0.664	1.000	1.000
550	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(8), CYP51A1(4), DHCR24(6), DHCR7(2), EBP(2), FDFT1(1), FDPS(8), GGCX(9), GGPS1(2), HMGCR(12), HSD17B7(5), IDI1(3), IDI2(1), LSS(6), MVD(3), MVK(3), NQO1(3), NSDHL(10), PMVK(3), SQLE(5), TM7SF2(2), VKORC1(1)	6930322	99	30	98	51	28	43	18	0	10	0	0.994	1.000	1.000
551	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(5), CHPT1(1), HEMK1(2), LCMT1(2), LCMT2(9), METTL2B(4), METTL6(4), PCYT1A(3), PCYT1B(4), PRMT2(1), PRMT3(8), PRMT5(10), PRMT6(5), PRMT7(5), PRMT8(7), WBSCR22(2)	5002863	72	30	71	28	18	30	7	2	15	0	0.748	1.000	1.000
552	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(4), ALDH3A2(3), ALDH9A1(2), ECHS1(3), EHHADH(10), HADHA(5), SDS(1)	4375145	66	30	65	31	19	25	15	2	5	0	0.870	1.000	1.000
553	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	8	CD44(5), ICAM1(2), ITGA4(10), ITGAL(17), ITGB1(8), ITGB2(15), SELE(5), SELL(5)	4471919	67	30	65	28	19	24	12	0	12	0	0.769	1.000	1.000
554	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(4), PSMA2(4), PSMA3(5), PSMA4(2), PSMA5(2), PSMA6(1), PSMA7(2), PSMB1(2), PSMB2(2), PSMB3(2), PSMB4(1), PSMB5(3), PSMB6(4), PSMB7(2), PSMC3(1), PSMD14(2), RPN1(3), RPN2(5), UBE2A(3), UBE3A(16)	4871346	66	30	64	24	21	15	14	1	15	0	0.750	1.000	1.000
555	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(17), ACO2(7), FH(8), IDH1(4), IDH2(5), MDH1(2), MDH2(4), SDHB(2), SUCLA2(5)	3292258	54	30	54	26	23	15	11	0	5	0	0.879	1.000	1.000
556	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(6), GNAQ(3), GNB1(2), GNGT1(1), HTR2C(16), PLCB1(5), TUB(13)	2575796	46	30	44	19	15	12	10	4	5	0	0.782	1.000	1.000
557	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(6), AKR1D1(8), CYP11A1(9), CYP11B1(8), CYP11B2(8), CYP17A1(3), CYP21A2(6), HSD11B1(6), HSD3B1(3), HSD3B2(6)	3205297	63	29	63	25	17	24	8	1	13	0	0.703	1.000	1.000
558	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(5), FOS(3), HRAS(1), JUN(1), MAP2K1(2), MAPK1(2), MAPK3(3), MYC(8), NFKB1(10), NFKBIA(3), PLCB1(5), PRKCA(11), RAF1(9), RELA(6)	5458669	69	29	68	27	19	21	20	2	7	0	0.738	1.000	1.000
559	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(8), CYSLTR2(5), GPR161(7), GPR171(5), GPR18(3), GPR34(9), GPR39(9), GPR45(3), GPR65(11), GPR68(6), GPR75(8)	3643783	74	29	69	31	28	21	20	0	5	0	0.666	1.000	1.000
560	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(6), AKR1D1(8), CYP11A1(9), CYP11B1(8), CYP11B2(8), CYP17A1(3), CYP21A2(6), HSD11B1(6), HSD3B1(3), HSD3B2(6)	3205297	63	29	63	25	17	24	8	1	13	0	0.703	1.000	1.000
561	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(3), F13B(15), HSD17B1(4), HSD17B2(2), HSD17B3(7), HSD17B4(12), HSD17B7(5), HSD3B1(3), HSD3B2(6)	2949521	57	29	55	21	12	27	6	0	12	0	0.689	1.000	1.000
562	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(11), KHK(2), LCT(32), MPI(5), PGM1(6), PYGL(8), PYGM(10), TPI1(2)	4908197	76	28	76	36	20	29	19	0	8	0	0.928	1.000	1.000
563	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(8), CYP11A1(9), CYP11B2(8), CYP17A1(3), HSD11B1(6), HSD3B1(3), HSD3B2(6)	2498956	43	28	43	19	11	16	8	0	8	0	0.732	1.000	1.000
564	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(2), HK1(11), HK2(9), HK3(9), IMPA1(3), IMPA2(6), ISYNA1(2), PGM1(6), PGM3(3), TGDS(4)	4130241	55	28	55	28	21	15	12	0	7	0	0.915	1.000	1.000
565	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(11), CS(6), MDH1(2), ME1(12), PC(12), PDHA1(7), SLC25A1(2), SLC25A11(3)	3287841	55	28	55	28	15	26	7	1	6	0	0.938	1.000	1.000
566	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5(2), CDK5R1(3), DAB1(6), FYN(5), LRP8(4), RELN(48), VLDLR(4)	5115071	72	28	69	32	10	33	19	1	8	1	0.947	1.000	1.000
567	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(6), LDLR(7), MBTPS1(9), MBTPS2(10), SCAP(11), SREBF1(2), SREBF2(13)	4072172	58	28	57	25	22	20	9	0	7	0	0.711	1.000	1.000
568	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(2), B3GALNT1(6), B3GALT5(4), FUT1(4), FUT2(1), FUT9(9), GBGT1(6), GLA(9), HEXA(3), HEXB(5), NAGA(4), ST3GAL1(2), ST3GAL2(6), ST8SIA1(2)	3755630	63	27	59	25	20	26	9	1	7	0	0.657	1.000	1.000
569	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	AKR1A1(1), ECHS1(3), EHHADH(10), HADH(1), HADHA(5), HSD17B10(4), HSD17B4(12), NTAN1(3), SIRT1(6), SIRT2(7), SIRT5(5), SIRT7(6), VNN2(11)	4305314	74	27	72	26	19	31	18	0	6	0	0.714	1.000	1.000
570	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(8), CDC25A(8), CDC25B(3), CDC25C(5), CSK(1), GRB2(3), PRKCA(11), PTPRA(10), SRC(3)	3330501	52	27	51	25	19	10	13	0	10	0	0.936	1.000	1.000
571	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(2), FDFT1(1), FDPS(8), HMGCR(12), IDI1(3), LSS(6), MVD(3), MVK(3), NQO1(3), NQO2(5), PMVK(3), SQLE(5), VKORC1(1)	3924470	55	26	53	27	16	22	12	0	5	0	0.938	1.000	1.000
572	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	CASP3(4), CASP7(1), DFFB(4), ENDOG(1), GZMB(4), HMGB1(4), HMGB2(4), TOP2A(14), TOP2B(24)	3857901	60	26	59	21	9	20	15	0	16	0	0.922	1.000	1.000
573	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(2), FUT1(4), FUT2(1), FUT9(9), GBGT1(6), GLA(9), HEXA(3), HEXB(5), NAGA(4), ST3GAL1(2), ST3GAL2(6), ST3GAL4(3), ST8SIA1(2)	3538266	56	26	55	23	18	23	10	1	4	0	0.714	1.000	1.000
574	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(3), PLCG1(12), PRKCA(11), PTK2B(15)	2445611	41	26	40	24	19	10	9	0	3	0	0.979	1.000	1.000
575	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(7), CS(6), FH(8), IDH2(5), MDH1(2), OGDH(13), SDHA(14), SUCLA2(5)	3504439	60	26	60	25	25	19	12	0	4	0	0.648	1.000	1.000
576	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(3), NFKB1(10), NFKBIA(3), PLCB1(5), PRKCA(11), RELA(6)	2991782	38	26	38	21	10	11	9	2	6	0	0.974	1.000	1.000
577	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	HRAS(1), MMP14(7), MMP2(7), MMP9(12), RECK(13), TIMP1(3), TIMP2(2), TIMP3(7), TIMP4(1)	2748434	53	26	53	23	11	23	11	0	8	0	0.781	1.000	1.000
578	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(14), CD44(5), CSF1(6), FCGR3A(1), IL1B(2), IL6R(7), SELL(5), SPN(1), TGFB1(1), TGFB2(5), TNFRSF1A(4), TNFRSF1B(2), TNFRSF8(6), TNFSF8(1)	4738496	60	26	57	30	18	19	13	0	10	0	0.933	1.000	1.000
579	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(2), ADH1B(5), ADH4(4), ADH6(9), ADH7(4), ADHFE1(5), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(4), ALDH3A2(3), ALDH7A1(1), ALDH9A1(2)	4869763	56	25	55	22	23	14	11	2	6	0	0.557	1.000	1.000
580	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(6), AASDH(10), AASDHPPT(9), AASS(12), KARS(5)	2587026	42	25	39	19	6	19	12	1	4	0	0.954	1.000	1.000
581	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(2), HK1(11), HK2(9), HK3(9), IMPA1(3), PGM1(6), PGM3(3), TGDS(4)	3696126	47	25	47	23	16	14	11	0	6	0	0.900	1.000	1.000
582	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(2), B4GALT7(4), HS3ST1(5), HS3ST2(5), HS3ST3A1(2), HS3ST3B1(5), XYLT1(16), XYLT2(4)	2130232	43	24	43	20	21	11	8	0	3	0	0.772	1.000	1.000
583	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(2), B4GALT7(4), HS3ST1(5), HS3ST2(5), HS3ST3A1(2), HS3ST3B1(5), XYLT1(16), XYLT2(4)	2130232	43	24	43	20	21	11	8	0	3	0	0.772	1.000	1.000
584	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	9	B3GALT1(12), B3GALT2(8), B3GALT5(4), B3GNT5(6), FUT1(4), FUT2(1), FUT3(8), ST3GAL3(6), ST3GAL4(3)	2404103	52	24	50	17	20	15	9	1	7	0	0.418	1.000	1.000
585	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(5), B4GALT1(2), B4GALT2(5), B4GALT3(10), B4GALT5(2), FUT8(10), ST3GAL1(2), ST3GAL2(6), ST3GAL3(6), ST3GAL4(3)	2788833	51	24	49	21	25	12	10	1	3	0	0.802	1.000	1.000
586	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(4), ALDH3A2(3), ALDH9A1(2)	2852783	47	23	46	19	16	17	8	2	4	0	0.589	1.000	1.000
587	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(10), ALDH1A2(11), ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(4), ALDH3A2(3), ALDH9A1(2)	2852783	47	23	46	19	16	17	8	2	4	0	0.589	1.000	1.000
588	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(4), EPHX2(7), HSD3B7(5), RDH11(1), RDH12(5), RDH13(4), RDH14(2)	1698250	28	23	28	12	12	9	4	1	2	0	0.695	1.000	1.000
589	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(6), ACAT2(4), ACYP1(2), ECHS1(3), EHHADH(10), GCDH(4), HADHA(5), SDHB(2), SDS(1)	2849217	37	22	37	14	7	15	11	0	4	0	0.722	1.000	1.000
590	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(5), ACAA2(3), ACAT1(6), ACAT2(4), ECHS1(3), EHHADH(10), HADHA(5), HADHB(4), SDS(1)	3075552	41	22	41	16	11	14	13	0	3	0	0.715	1.000	1.000
591	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(3), ALAS1(8), ALAS2(10), CPOX(6), FECH(7), HMBS(8), UROD(3), UROS(3)	2842724	48	22	46	13	20	16	7	0	5	0	0.399	1.000	1.000
592	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	ADAM17(11), DLL1(6), FURIN(6), NOTCH1(10), PSEN1(5)	2760552	38	22	38	25	14	13	5	0	5	1	0.958	1.000	1.000
593	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(4), PSMA2(4), PSMA3(5), PSMA4(2), PSMA5(2), PSMA6(1), PSMA7(2), PSMB1(2), PSMB10(2), PSMB2(2), PSMB3(2), PSMB4(1), PSMB5(3), PSMB6(4), PSMB7(2), PSMB8(1), PSMB9(1)	3015723	40	22	38	14	11	10	7	0	12	0	0.655	1.000	1.000
594	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(5), ACTR2(6), ACTR3(1), ARPC1A(6), ARPC1B(5), ARPC2(1), ARPC3(1), ARPC4(1), CDC42(3), RAC1(1), WASF1(3), WASL(8)	3012972	41	22	41	13	16	16	2	0	7	0	0.467	1.000	1.000
595	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(6), CAMP(1), DAG1(6), GNAQ(3), ITPKA(1), ITPKB(11)	2031746	28	22	28	10	10	13	1	0	4	0	0.472	1.000	1.000
596	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(4), CHAT(5), CHKA(9), PCYT1A(3), PDHA1(7), PDHA2(9), PEMT(1), SLC18A3(6)	2387107	44	21	43	26	9	19	8	1	6	1	0.968	1.000	1.000
597	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(8), ALDH1B1(7), ALDH2(2), ALDH3A1(4), ALDH3A2(3), ALDH7A1(1), ALDH9A1(2), MIOX(5), UGDH(2)	3009817	34	21	33	18	16	11	4	2	1	0	0.856	1.000	1.000
598	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(6), AASDHPPT(9), AASS(12), KARS(5)	1761211	32	21	29	13	6	17	7	1	1	0	0.890	1.000	1.000
599	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	11	BPNT1(3), CHST11(8), CHST12(3), PAPSS1(8), PAPSS2(7), SULT1A1(3), SULT1A2(1), SULT1E1(9), SULT2A1(7), SULT2B1(4), SUOX(2)	3159305	55	21	51	18	27	20	5	0	3	0	0.442	1.000	1.000
600	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(3), ADORA2A(6), ADORA2B(1), ADORA3(4), LTB4R(2), P2RY1(3), P2RY2(3), P2RY6(4)	2030439	26	21	26	17	11	6	9	0	0	0	0.953	1.000	1.000
601	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(6), PLCD1(4), PRKCA(11), TGM2(10)	1783266	31	21	31	16	15	7	6	0	3	0	0.830	1.000	1.000
602	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	CDK5(2), CDK5R1(3), DPM2(1), EGR1(6), HRAS(1), KLK2(2), MAP2K1(2), MAP2K2(5), MAPK1(2), MAPK3(3), NGFR(3), RAF1(9)	2829678	39	20	38	19	19	11	7	0	2	0	0.763	1.000	1.000
603	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(9), PARK2(5), SNCA(3), SNCAIP(10), UBE2E2(3), UBE2F(1), UBE2G1(2), UBE2L3(2), UBE2L6(3)	2308876	38	20	38	16	9	17	8	0	3	1	0.787	1.000	1.000
604	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	6	FUT1(4), FUT2(1), FUT3(8), FUT5(1), FUT6(10), ST3GAL3(6)	1510570	30	19	30	13	18	9	1	0	2	0	0.545	1.000	1.000
605	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(11), GLS2(7), GLUD1(3), GLUD2(9)	1620963	30	19	29	14	9	9	6	0	6	0	0.936	1.000	1.000
606	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CASP3(4), CD36(8), FOS(3), FYN(5), JUN(1), MAPK14(4), THBS1(10)	2646788	35	19	35	14	10	10	7	0	8	0	0.724	1.000	1.000
607	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(8), ACADM(9), ACADS(3), ACAT1(6), ECHS1(3), HADHA(5)	1930428	34	18	34	12	6	14	11	0	3	0	0.689	1.000	1.000
608	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(8), CYCS(2), GPD2(3), NDUFA1(1), SDHA(14), SDHB(2), SDHC(2), SDHD(3), UQCRC1(2)	2400407	37	18	37	12	17	10	6	0	4	0	0.518	1.000	1.000
609	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(4), ALPL(5), ALPP(3), ALPPL2(3), DHFR(4), FPGS(5), GCH1(1), GGH(2), SPR(1)	2130667	28	18	28	13	11	11	4	0	2	0	0.652	1.000	1.000
610	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(11), CYP2E1(2), NR1I3(4), PTGS1(5), PTGS2(9)	1942207	31	17	30	10	12	9	6	1	3	0	0.539	1.000	1.000
611	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	CASP3(4), CASP8(21), CFL1(1), CFLAR(2), PDE6D(2)	1403178	30	17	28	10	4	12	5	0	9	0	0.683	1.000	1.000
612	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(3), PAPSS1(8), PAPSS2(7), SULT1A2(1), SULT1E1(9), SULT2A1(7), SUOX(2)	2256029	37	17	34	11	18	13	3	0	3	0	0.622	1.000	1.000
613	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(1), ECHS1(3), EHHADH(10), HADHA(5), SDS(1)	1772376	20	16	20	16	3	9	7	0	1	0	0.997	1.000	1.000
614	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD28(3), CD4(6), CD80(5), HLA-DRA(1), IL10(4), IL2(2), IL4(1)	1330988	22	15	22	10	5	8	3	1	5	0	0.847	1.000	1.000
615	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(18), PDXK(4), PNPO(1), PSAT1(5)	1718955	28	15	28	12	6	13	4	0	5	0	0.790	1.000	1.000
616	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	GBA(4), GGT1(5), SHMT1(5), SHMT2(5)	2046382	19	14	19	10	7	8	2	0	2	0	0.827	1.000	1.000
