Hybridization REF p difference q subclass Composite Element REF p difference q subclass MYH11|MYH11 3.3864394122273e-15 1.38204013449503 1.85362999406126e-14 1 RICTOR|RICTOR 8.25191313978683e-12 1.24746584551719 3.43279586615132e-11 1 CAV1|CAVEOLIN-1 4.40487650834779e-21 1.15767423047976 4.36292530350638e-20 1 FN1|FIBRONECTIN 4.40973818266229e-22 0.914909583711994 5.09569745552087e-21 1 HSPA1A|HSP70 8.71964962328823e-26 0.890552572583652 1.81368712164395e-24 1 COL6A1|COLLAGEN_VI 3.47161518512964e-28 0.710170436842628 1.20349326417828e-26 1 MAPK1 MAPK3|MAPK_PT202_Y204 3.61775974195899e-13 0.598552369568373 1.7102136961988e-12 1 SERPINE1|PAI-1 3.86447941148438e-05 0.527039825330023 7.24154700530406e-05 1 ACVRL1|ACVRL1 8.90100689825508e-32 0.460696673492743 6.17136478279019e-30 1 TGM2|TRANSGLUTAMINASE 5.47641697036e-11 0.452516472485867 2.14923533931109e-10 1 ANXA1|ANNEXIN-1 3.56621899187784e-06 0.450442530223835 7.4926621243494e-06 1 YAP1|YAP_PS127 2.43109837681525e-08 0.435338856566081 6.83335759969692e-08 1 LCK|LCK 3.75802314452747e-19 0.406375302690604 3.00641851562198e-18 1 GATA6|GATA6 6.13912553912311e-11 0.36621277144 2.36470020766223e-10 1 CCND1|CYCLIN_D1 7.50739128066148e-18 0.345811201669977 5.03721737541157e-17 1 STMN1|STATHMIN 1.83542331090122e-21 0.342347416974026 1.90884024333727e-20 1 STAT3|STAT3_PY705 1.18548047094224e-10 0.334689119665393 4.48327159919974e-10 1 WWTR1|TAZ 1.13569760158779e-26 0.324116263883881 2.95281376412825e-25 1 MAP2K1|MEK1_PS217_S221 1.12322836868771e-17 0.313873363912911 7.30098439647011e-17 1 CDH2|N-CADHERIN 1.26041208980863e-15 0.304317864402597 7.08555985622149e-15 1 MYC|C-MYC 1.89242891995702e-09 0.299574199569137 6.05577254386246e-09 1 STK11|LKB1 1.88612599693055e-22 0.286586335883881 2.30773063153855e-21 1 PREX1|PREX1 9.7082664228997e-08 0.285958337987013 2.46258465361358e-07 1 MRE11A|MRE11 6.94250086764806e-24 0.268782942998472 1.11080013882369e-22 1 RAD51|RAD51 8.46061904344948e-08 0.267816650793736 2.17260340868826e-07 1 BCL2|BCL-2 1.58986297591611e-13 0.265088685303285 7.87360711882264e-13 1 RICTOR|RICTOR_PT1135 1.28909302352963e-17 0.254681688274255 8.12519239073221e-17 1 BID|BID 4.49234901305593e-16 0.252374161906035 2.59557942976565e-15 1 PRKCA |PKC-ALPHA_PS657 4.95288228579258e-05 0.251434502799847 9.19820995932908e-05 1 AKT1 AKT2 AKT3|AKT_PT308 9.2072539439306e-07 0.246815966051184 2.03734980886975e-06 1 CDKN1A|P21 0.00128170479303963 0.245475620637128 0.00197477479223884 1 CDK1|CDK1 1.92451524070137e-09 0.238411378737968 6.0651389403922e-09 1 YAP1|YAP 1.48465549230806e-08 0.23155828999618 4.23025126575447e-08 1 PGR|PR 1.55947054542147e-16 0.230060170368984 9.26771066993331e-16 1 MAPK8|JNK_PT183_PY185 1.50867152596151e-10 0.227496734362872 5.60363709642847e-10 1 RAF1|C-RAF_PS338 1.27505440709643e-18 0.223067550830405 9.8226413583725e-18 1 PEA15|PEA15 2.53294412631908e-08 0.216126931674561 7.02469837699158e-08 1 PARK7|DJ-1 1.6697254866757e-11 0.201648059928189 6.80986080840285e-11 1 KIT|C-KIT 0.000479438303656398 0.199615613254393 0.000767101285850237 1 NRG1|HEREGULIN 7.57546635958396e-07 0.191735482734912 1.73153516790491e-06 1 ESR1|ER-ALPHA 2.2929154243537e-07 0.190237311940413 5.50310300440763e-07 1 RAB11A RAB11B|RAB11 2.63716842360045e-10 0.188844564874714 9.6233514405069e-10 1 IGFBP2|IGFBP2 0.00912903163263443 0.188624746236058 0.0122505714812127 1 AXL|AXL 0.0425582990977575 0.179999278840645 0.0530067437864285 1 FOXO3|FOXO3A_PS318_S321 4.28750239959378e-10 0.177477966398778 1.4619680313369e-09 1 CDKN1B|P27 5.6393303172081e-08 0.177231392980138 1.48478570377125e-07 1 PRKCA |PKC-ALPHA 0.00826114048600615 0.171696612922078 0.0111579040330473 1 RPS6KA1|P90RSK_PT359_S363 4.16878283213404e-08 0.164165653042017 1.126112765044e-07 1 YBX1|YB-1 1.38035003244975e-05 0.157367605069519 2.73440768332903e-05 1 PECAM1|CD31 1.4269150994034e-05 0.153406860905271 2.79998434599912e-05 1 CHEK2|CHK2_PT68 4.45853738655739e-06 0.145496962815126 9.27375776403937e-06 1 RB1|RB 1.35337312162602e-07 0.14418717016272 3.39158565419533e-07 1 YWHAB|14-3-3_BETA 4.94378406052158e-09 0.143370137135982 1.53478669341565e-08 1 SNAI1|SNAIL 0.000263977888432954 0.141551763928189 0.000439259206352435 1 ANXA7|ANNEXIN_VII 9.65964052454448e-07 0.139848748449198 2.11495287274237e-06 1 RPS6KB1|P70S6K_PT389 0.000204813186102628 0.139571568452254 0.000346350753734525 1 MET|C-MET 1.31787253873669e-05 0.13744376412605 2.63574507747338e-05 1 BECN1|BECLIN 2.45667807244647e-05 0.135851262136746 4.68797283549418e-05 1 XBP1|XBP1 0.00215829573706705 0.133142560053476 0.00313933925391571 1 TIGAR|TIGAR 8.33819377973733e-07 0.12957778097861 1.86488635073695e-06 1 PIK3R1 PIK3R2|PI3K-P85 0.000307071765410602 0.129205326511841 0.000506912120677819 1 NKX2-1|TTF1 0.000195601573583168 0.12126219137913 0.000333484650043434 1 MAPK14|P38_MAPK 0.00147847904805313 0.120911470632544 0.0022446981167522 1 MET|C-MET_PY1235 7.09684121971633e-10 0.119491520223835 2.38087576403387e-09 1 PEA15|PEA15_PS116 0.00311808373031854 0.105706853093965 0.00450389872157122 1 NRAS|N-RAS 2.65419565609286e-05 0.10186118865317 5.01884269515741e-05 1 BCL2L1|BCL-XL 0.0052923579788179 0.0999653791023682 0.00733873639729416 1 CDKN1B|P27_PT198 0.00013659476171343 0.0931588003598166 0.00023875386921339 1 ERBB3|HER3_PY1289 7.7393453780106e-05 0.0908741283430099 0.000141209108651421 1 SETD2|SETD2 0.00478918083359758 0.0902094907906799 0.00671549745337616 1 BAX|BAX 0.0164776546084649 0.0889196004132926 0.0215556739532119 1 FOXO3|FOXO3A 0.00129950654076688 0.0868733013491215 0.00198748059176111 1 ETS1|ETS-1 0.0341552430343551 0.0785521481871658 0.0427969310309992 1 EGFR|EGFR_PY1173 8.79105313637573e-05 0.0776402049724981 0.000156285389091124 1 ERRFI1|MIG-6 0.00481062077188965 0.0694358940718105 0.00671549745337616 1 DIRAS3|ARHI 0.0132557748109107 0.0693630505584416 0.0175617908322893 1 YBX1|YB-1_PS102 0.0191187300396266 0.0685815708082506 0.0246999742126853 1 RPTOR|RAPTOR 0.0338415086827662 0.0656780708059587 0.0426608109455477 1 CDKN1B|P27_PT157 0.0103175970400533 0.0453668875324675 0.0137567960534044 1 YWHAE|14-3-3_EPSILON 0.0464652954264136 0.0369903339702063 0.0575284610041311 1 MS4A1|CD20 0.000240917617119848 -0.0663914656394194 0.000404119873878455 1 BIRC2 |CIAP 0.00749483759869836 -0.0697195797249809 0.0102121750103883 1 JUN|C-JUN_PS73 0.00615325398465343 -0.0848242485286478 0.00847600548879413 1 IRS1|IRS1 0.00202120296641316 -0.0973709006462949 0.00296063533108407 1 AKT1S1|PRAS40_PT246 9.41067987866854e-05 -0.0979759330359053 0.000165883170742632 1 GSK3A GSK3B|GSK3-ALPHA-BETA 0.00158277663975369 -0.101644091533995 0.00238563435557078 1 PCNA|PCNA 0.00182863603053123 -0.115187340306341 0.00271617045570918 1 PRKCD|PKC-DELTA_PS664 0.000358518195907216 -0.117157991763178 0.000582592068349226 1 TP53|P53 0.0280418945268464 -0.118206360033613 0.0357835218502089 1 SRSF1|SF2 0.00164727013845915 -0.122103848135982 0.00246497977553599 1 ARID1A|ARID1A 0.00367286321000452 -0.125891857849677 0.00523257224439 1 SCD|SCD 0.000154357614073634 -0.126102926718869 0.000267553197727632 1 PDK1|PDK1_PS241 0.000624702280908254 -0.126521964344538 0.000991893697930663 1 EGFR|EGFR 0.0190876818046684 -0.12677630750573 0.0246999742126853 1 ERCC1|ERCC1 1.96809294844304e-05 -0.131126737369748 3.79040123403845e-05 1 RAD50|RAD50 1.01021409752419e-05 -0.138275681478228 2.08044091371318e-05 1 ITGA2|CD49B 0.022529291707706 -0.148606166459893 0.0289264979950793 1 MYH9|MYOSIN-IIA 0.0315583096667013 -0.155870272913548 0.0400251732358163 1 EIF4EBP1|4E-BP1 0.00119913672235185 -0.156962057844156 0.00186134655409839 1 AR|AR 0.000920884921011126 -0.160918920357525 0.00144018092910011 1 SMAD1|SMAD1 6.80524171822579e-09 -0.164044954574484 2.05790592918688e-08 1 PARP1|PARP1 0.00184125016468747 -0.17353151148 0.00271617045570918 1 COPS5|JAB1 1.08757763163981e-05 -0.177979839278841 2.21780536648118e-05 1 RPS6|S6_PS235_S236 0.0140456193873345 -0.18211631620932 0.0184904356491492 1 XRCC1|XRCC1 1.88175308221898e-07 -0.185733159297937 4.65957906073271e-07 1 NF2|NF2 4.87336775969591e-08 -0.189861793663102 1.29956473591891e-07 1 CHEK1|CHK1_PS345 7.28094587547305e-09 -0.190884527722689 2.16348106014056e-08 1 ADAR|ADAR1 2.16142875281399e-07 -0.191341445335304 5.28914330100365e-07 1 SMAD3|SMAD3 1.96790225931997e-12 -0.202040180514897 8.5275764570532e-12 1 BAD|BAD_PS112 1.08358187500652e-08 -0.207256818579068 3.17443704227262e-08 1 RAF1|C-RAF 3.70346131795929e-10 -0.209304236919786 1.30562704090768e-09 1 ESR1|ER-ALPHA_PS118 2.10824028489581e-18 -0.211055285699007 1.46171326419443e-17 1 ERBB2|HER2_PY1248 8.63522781923652e-05 -0.21240850702903 0.000154838567793207 1 DVL3|DVL3 3.14187769234176e-08 -0.22721262207563 8.59882315798797e-08 1 CTNNA1|ALPHA-CATENIN 3.02501880908339e-06 -0.23060780989658 6.42044808458515e-06 1 EEF2|EEF2 8.10080426518014e-07 -0.231245964619557 1.8314861816929e-06 1 EIF4EBP1|4E-BP1_PT37_T46 0.00342478205655537 -0.231416906871658 0.00491279081216219 1 EGFR|EGFR_PY1068 0.00416485396583347 -0.232491296934301 0.00589312669995484 1 AKT1 AKT2 AKT3|AKT 0.000157690015798696 -0.234467328176471 0.00027107044038123 1 SHC1|SHC_PY317 2.90585391117122e-10 -0.245988076906035 1.0420993336614e-09 1 TUBA1B|ACETYL-A-TUBULIN-LYS40 0.0075118402720645 -0.249646814875477 0.0102121750103883 1 SYK|SYK 0.000332885028647308 -0.257978256838044 0.000545197527233386 1 PRKCB|PKC-PAN_BETAII_PS660 1.30203859507887e-05 -0.265744253129106 2.62935949297481e-05 1 RPS6KA1|P90RSK 4.30316251541301e-12 -0.276651150087853 1.82664857797124e-11 1 DIABLO|SMAC 6.82670716893723e-09 -0.280261573535523 2.05790592918688e-08 1 RPS6|S6_PS240_S244 7.32223820614093e-05 -0.281173250850267 0.00013478102184755 1 FOXM1|FOXM1 2.71255388746746e-13 -0.282127468723453 1.3121190897517e-12 1 MYH9|MYOSIN-IIA_PS1943 3.36104466847575e-07 -0.296144676093201 7.76774767825507e-07 1 CHEK2|CHK2 2.85708143695819e-11 -0.300971503506493 1.14283257478328e-10 1 MTOR|MTOR 7.97001238027336e-13 -0.310466606521772 3.60383168499317e-12 1 CCNE2|CYCLIN_E2 1.26682614012517e-22 -0.32274055171123 1.64687398216272e-21 1 ERBB3|HER3 1.40633129560741e-06 -0.329534949213904 3.04705114048272e-06 1 GAPDH|GAPDH 8.15873422385238e-05 -0.345245556215432 0.000147566671179243 1 CCNE1|CYCLIN_E1 7.81506499195198e-10 -0.381018231344538 2.58021193385081e-09 1 SQSTM1|P62-LCK-LIGAND 4.20668841768045e-10 -0.381501980651642 1.45831865146256e-09 1 INPP4B|INPP4B 1.71645842781375e-06 -0.381725091847212 3.68065312355938e-06 1 BRD4|BRD4 0.000420926351831468 -0.388948800564516 0.000678702954891049 1 PDCD4|PDCD4 6.14343712923824e-08 -0.395832344126814 1.59729365360194e-07 1 TFRC|TFRC 1.80702800845289e-05 -0.401979348560733 3.51272734353459e-05 1 MSH2|MSH2 2.97631099756789e-19 -0.408226745202445 2.5794695312255e-18 1 SLC1A5|SLC1A5 0.000725319378190489 -0.44108751536 0.00114292750502744 1 SRC|SRC 4.92122162669015e-14 -0.441496271834225 2.49661975207695e-13 1 RB1|RB_PS807_S811 1.19523077668351e-08 -0.447081459055004 3.45288891041903e-08 1 CCNB1|CYCLIN_B1 2.88935195979755e-07 -0.452159961319328 6.75264278244821e-07 1 PXN|PAXILLIN 2.30177866049742e-07 -0.492430635893048 5.50310300440763e-07 1 ACACA|ACC1 8.96233001200256e-13 -0.501928208733384 3.96630774999262e-12 1 STAT5A|STAT5-ALPHA 2.83684265905883e-07 -0.515529780729565 6.70526446686633e-07 1 RAB25|RAB25 1.23972612445658e-09 -0.520231884488159 4.02910990448389e-09 1 TSC2|TUBERIN 1.45829034632009e-14 -0.560581488419404 7.58310980086447e-14 1 RPS6KB1|P70S6K 4.91181951998312e-21 -0.584632295304813 4.6439020916204e-20 1 ACACA ACACB|ACC_PS79 1.92892669420247e-18 -0.604357164599694 1.38350604273832e-17 1 EEF2K|EEF2K 1.40123181567528e-21 -0.610600643262796 1.53398009294978e-20 1 BAP1|BAP1-C-4 3.09431654865968e-33 -0.643364118954163 3.21808921060607e-31 1 PTEN|PTEN 7.7196414406375e-21 -0.646942977776929 6.9812409550113e-20 1 MSH6|MSH6 1.07463061190614e-24 -0.664499874935065 1.86269306063731e-23 1 XRCC5|KU80 2.96563510374851e-27 -0.690731460789916 8.81217287970986e-26 1 EIF4G1|EIF4G 1.39885213331313e-17 -0.695492752811306 8.55768363909209e-17 1 TP53BP1|53BP1 2.3834984790625e-30 -0.747077219005348 1.2394192091125e-28 1 BRAF|B-RAF 9.33199086310404e-23 -0.764689528932773 1.29403606635043e-21 1 FASN|FASN 1.58474829918479e-18 -0.816726988641711 1.17724159368013e-17 1 GATA3|GATA3 3.38949426621066e-19 -0.818812472226127 2.82005922948727e-18 1 CLDN7|CLAUDIN-7 4.14417992650526e-15 -0.905429349983957 2.21022929413614e-14 1 RPS6|S6 3.47732008352626e-23 -0.916042590799083 5.16630412409616e-22 1 RBM15|RBM15 1.51713100484649e-34 -1.03045576123759 3.1556324900807e-32 1 VHL|VHL 4.06972043423985e-13 -1.12179964508785 1.88111522293753e-12 1 ERBB2|HER2 4.20597719290513e-26 -1.1298644722139 9.72048062360297e-25 1 CTNNB1|BETA-CATENIN 2.09965138476144e-29 -1.19123369636516 8.73454976060759e-28 1 CDH1|E-CADHERIN 3.66615831165676e-25 -1.68663847666769 6.93237208022369e-24 1 CDH1|E-CADHERIN 1.14944156904599e-37 1.62720130510783 2.39083846361566e-35 2 ERBB2|HER2 6.82734401625726e-36 1.32178283940083 4.73362518460503e-34 2 VHL|VHL 1.47685636165303e-16 1.15918234648219 7.87656726214949e-16 2 CTNNB1|BETA-CATENIN 1.20186071766111e-32 1.04538471269563 4.99974058547022e-31 2 GATA3|GATA3 6.00986487835531e-27 0.98926074542772 1.13641081336173e-25 2 CLDN7|CLAUDIN-7 1.18945283009116e-17 0.981909961487179 7.43939560097209e-17 2 SRC|SRC_PY527 1.96707592480309e-22 0.88988571896729 2.12135412899305e-21 2 PDCD4|PDCD4 6.60854646590356e-28 0.837745971632017 1.37457766490794e-26 2 RB1|RB_PS807_S811 1.69895352028099e-24 0.777554292817464 2.71832563244958e-23 2 FASN|FASN 4.33014289608051e-18 0.770911772783229 2.90538620124112e-17 2 BRAF|B-RAF 1.08437024626991e-22 0.673336874562439 1.32388298309127e-21 2 SRC|SRC 1.00908900187773e-24 0.655315250753985 1.74908760325473e-23 2 RAB25|RAB25 4.16582371724814e-20 0.641751035001247 3.46596533275045e-19 2 EIF4EBP1|4E-BP1_PT37_T46 2.88905392254904e-17 0.626706669612474 1.66923115525056e-16 2 ACACA ACACB|ACC_PS79 9.450755860828e-19 0.609327494768122 6.7784731691456e-18 2 INPP4B|INPP4B 2.70910153421935e-12 0.584843399092862 9.55073083250211e-12 2 RBM15|RBM15 8.20055344281094e-18 0.582571203695496 5.33035973782711e-17 2 GSK3A GSK3B|GSK3_PS9 1.27601621303641e-21 0.528196708656133 1.15396248831119e-20 2 MAPK14|P38_PT180_Y182 1.52442238461775e-13 0.520369403982536 5.98263879246211e-13 2 TP53BP1|53BP1 4.19878915061446e-18 0.511729330703119 2.90538620124112e-17 2 GSK3A GSK3B|GSK3-ALPHA-BETA_PS21_S9 1.20938589410562e-19 0.508247537336244 9.67508715284496e-19 2 SRC|SRC_PY416 6.15216626476721e-15 0.495983780900624 2.84366796238129e-14 2 PTEN|PTEN 3.86779414353597e-16 0.492259422131809 1.91547900441781e-15 2 PRKCB|PKC-PAN_BETAII_PS660 1.26721661454647e-19 0.478150853706029 9.76226132687651e-19 2 EGFR|EGFR_PY1068 8.26437176873852e-08 0.469816673739155 1.93144868303102e-07 2 XRCC5|KU80 1.00135437647973e-16 0.453777656864172 5.48109763967852e-16 2 RPS6|S6 1.15444183116793e-08 0.427289979957727 2.89305904678228e-08 2 ERBB3|HER3 4.81265481816492e-12 0.420616485366597 1.66838700363051e-11 2 BAP1|BAP1-C-4 2.03976358557024e-22 0.412497333879695 2.12135412899305e-21 2 ERBB2|HER2_PY1248 8.68472040013913e-10 0.400580624171587 2.5806026331842e-09 2 TSC2|TUBERIN 8.76313754192832e-09 0.341998556323493 2.25028717126061e-08 2 PXN|PAXILLIN 2.86550578654276e-06 0.341773809590991 5.90123963961281e-06 2 EEF2K|EEF2K 9.00941246480887e-08 0.328905627724186 2.08217532520027e-07 2 AKT1 AKT2 AKT3|AKT_PS473 8.71597024029296e-07 0.319881143355787 1.88846021873014e-06 2 BAD|BAD_PS112 9.1057788775389e-24 0.315833084934858 1.26266800435206e-22 2 ACACA|ACC1 6.53692895334316e-06 0.314446567634234 1.30738579066863e-05 2 RPS6|S6_PS240_S244 1.35651742123277e-06 0.312768634760638 2.85005680420622e-06 2 DIABLO|SMAC 1.83124339004965e-11 0.301567348008732 6.14352621177947e-11 2 RPS6KB1|P70S6K 2.47845692907571e-09 0.29137513227623 6.69505248373698e-09 2 CTNNA1|ALPHA-CATENIN 4.38046223023977e-15 0.280209610784216 2.07076396338607e-14 2 CHEK1|CHK1_PS345 1.25517292910485e-17 0.263945687923493 7.45931340725168e-17 2 RPS6|S6_PS235_S236 0.000133092324193098 0.263612255086486 0.000230693361934703 2 SHC1|SHC_PY317 6.16040661793786e-14 0.257541605414692 2.56272915306215e-13 2 STAT5A|STAT5-ALPHA 0.00180840826084213 0.245993860866805 0.00298530887504098 2 COPS5|JAB1 1.65053844969193e-09 0.240339084368187 4.57749330047895e-09 2 CHEK2|CHK2 1.59431996096259e-09 0.235824122969508 4.48133178216512e-09 2 NFKB1|NF-KB-P65_PS536 4.33537652954182e-05 0.235386028295218 7.98016210747521e-05 2 SRSF1|SF2 1.64104129358033e-12 0.233068531822453 5.98836121166156e-12 2 MSH2|MSH2 1.23613596816885e-07 0.220300949450728 2.8254536415288e-07 2 AR|AR 5.22994979707441e-05 0.218661103592931 9.14142485539057e-05 2 EIF4G1|EIF4G 0.000779756895816085 0.211103013590714 0.00130797930911085 2 AKT1S1|PRAS40_PT246 4.63139646983688e-19 0.206587597604574 3.44046594902168e-18 2 RPS6KA1|P90RSK 1.03821465911891e-06 0.201446534251421 2.22627473295601e-06 2 TSC2|TUBERIN_PT1462 2.69303962939967e-12 0.201015281659321 9.55073083250211e-12 2 SCD|SCD 2.55037085094544e-09 0.187705990141649 6.80098893585451e-09 2 SMAD3|SMAD3 3.05187890047301e-08 0.180039095135828 7.38128850346961e-08 2 MYH9|MYOSIN-IIA_PS1943 5.10757977633647e-05 0.178061584603049 9.08014182459817e-05 2 CCNE1|CYCLIN_E1 0.00995181145903398 0.176393915913375 0.0148919193056048 2 PRKCD|PKC-DELTA_PS664 7.84449171976499e-10 0.176335326233818 2.43351166571011e-09 2 JUN|C-JUN_PS73 2.27782065559144e-10 0.173417938442827 7.40291713067218e-10 2 MTOR|MTOR 1.77645905061528e-07 0.171763835630215 4.01634220139107e-07 2 CDKN1A|P21 0.0174283900275755 0.168733990221067 0.0250007250050738 2 MSH6|MSH6 0.0182509656015217 0.156013747111435 0.0259176807443076 2 RAD50|RAD50 5.78507271224476e-08 0.155241362438531 1.36738082289422e-07 2 CCNE2|CYCLIN_E2 7.00840277321934e-06 0.143568501093139 1.37523375172606e-05 2 IRS1|IRS1 0.000345089832450899 0.142201541852945 0.000588349878276943 2 ESR1|ER-ALPHA_PS118 1.7619918972779e-09 0.136176933496189 4.82229361360267e-09 2 ARAF|A-RAF_PS299 1.16858166105629e-05 0.129365157937214 2.25060171758989e-05 2 ADAR|ADAR1 4.56264100796596e-05 0.104500050080364 8.32481868120105e-05 2 MTOR|MTOR_PS2448 0.000200616271275344 0.104039092470963 0.000344861028308029 2 AKT1 AKT2 AKT3|AKT_PT308 0.0442630403362573 0.102270694630353 0.0597838466879319 2 PDK1|PDK1_PS241 0.00441573545177386 0.0950125704742897 0.00701124407609895 2 PARP1|PARP_CLEAVED 0.0083366810976669 0.090528594633264 0.0126571508636111 2 MS4A1|CD20 0.00780957248480546 0.0500494643067221 0.0120325264951077 2 RB1|RB 0.0203327239928707 -0.0522692161214137 0.0283839368491081 2 PDK1|PDK1 0.0078795800796018 -0.0551628758672211 0.0120511224746851 2 GSK3A GSK3B|GSK3-ALPHA-BETA 0.0220032690176683 -0.0617546738601525 0.0305111997045 2 MAPK9|JNK2 0.0371478548491161 -0.0647560493343035 0.0505016588798441 2 YWHAE|14-3-3_EPSILON 3.6661686994888e-05 -0.0655336496643105 6.86993774318622e-05 2 PECAM1|CD31 0.0191367734885353 -0.0697238876981289 0.0268949249028064 2 BAK1|BAK 0.0115791163407066 -0.0768108997076923 0.0172032585633355 2 EIF4EBP1|4E-BP1_PT70 0.00352798629828163 -0.0794067562428274 0.0056885360468417 2 XBP1|XBP1 0.018316822449102 -0.0817843197880804 0.0259176807443076 2 NKX2-1|TTF1 0.00149549241211093 -0.0821997082937063 0.00248849937375259 2 ETS1|ETS-1 0.0258211328646296 -0.0833892163201663 0.0353341818147563 2 MAPK1|ERK2 0.00285863249183145 -0.0866833911981982 0.00464527779922611 2 EGFR|EGFR_PY1173 4.70477670554969e-07 -0.0882190403927928 1.04105697314291e-06 2 NRAS|N-RAS 4.56353690421999e-06 -0.0910604123295911 9.30603603997802e-06 2 PEA15|PEA15_PS116 0.0117265974017112 -0.0920672729539848 0.0172988103514605 2 ERBB3|HER3_PY1289 1.68557748365557e-05 -0.0924544564928621 3.18727378727599e-05 2 RAB11A RAB11B|RAB11 0.000619693517473888 -0.0941703991939016 0.0010479370051591 2 CDKN1B|P27 0.00393441556340899 -0.0998201549873874 0.00629506490145438 2 CDKN1B|P27_PT198 2.81224778521183e-08 -0.104298331150381 6.88173575675366e-08 2 MAP2K1|MEK1 0.00610608908336713 -0.105536903681081 0.00954937240105536 2 YWHAB|14-3-3_BETA 5.2033614698051e-08 -0.106524848133888 1.2440220525511e-07 2 RPTOR|RAPTOR 3.74806397955638e-05 -0.106856035952322 6.96069024774756e-05 2 CHEK2|CHK2_PT68 4.99738932018688e-05 -0.107209734805821 9.03875633564236e-05 2 CHEK1|CHK1 0.0121034708202906 -0.110151041367845 0.0177290276804257 2 BRCA2|BRCA2 0.00911761779907723 -0.112588196166667 0.0137424963928121 2 MET|C-MET_PY1235 1.34876320063322e-14 -0.114608959390714 5.96899459003638e-14 2 EIF4EBP1|4E-BP1 0.0139317581392471 -0.121780392680665 0.0201236506455791 2 BAX|BAX 5.08746180608301e-05 -0.132027166692723 9.08014182459817e-05 2 ERRFI1|MIG-6 1.01552611032768e-13 -0.144448644645184 4.14175354800309e-13 2 PCNA|PCNA 1.50169491299626e-05 -0.150190690455994 2.86561965048828e-05 2 RICTOR|RICTOR_PT1135 8.57117740698088e-11 -0.156332712639224 2.829849048654e-10 2 YAP1|YAP_PS127 0.0122696363816836 -0.157881185836175 0.0178467438279034 2 PRKCA |PKC-ALPHA 0.00764713770334954 -0.160401650757034 0.0118701838977366 2 PARK7|DJ-1 8.38957673658708e-10 -0.16381209968413 2.52903182784074e-09 2 ANXA7|ANNEXIN_VII 7.95571121482153e-10 -0.168265724365766 2.43351166571011e-09 2 MAP2K1|MEK1_PS217_S221 6.01171841767598e-06 -0.16848673795939 1.21401692318117e-05 2 BCL2L1|BCL-XL 8.70585699198452e-07 -0.169307564627581 1.88846021873014e-06 2 MAPK14|P38_MAPK 4.54915910509227e-07 -0.172213591150797 1.017446337483e-06 2 PGR|PR 1.76425114693896e-15 -0.174138021868884 8.53405205961171e-15 2 CDK1|CDK1 2.17264962993846e-08 -0.17428558624851 5.37989432175238e-08 2 RAF1|C-RAF_PS338 1.69639396419695e-14 -0.174396740927512 7.35104051152012e-14 2 SETD2|SETD2 1.09836523850068e-09 -0.175239451226611 3.21774605081889e-09 2 BCL2|BCL-2 4.7028833178927e-09 -0.188439903220651 1.23822750648314e-08 2 CCNB1|CYCLIN_B1 0.0242816203424808 -0.189078776430492 0.0334475300081855 2 PRKCA |PKC-ALPHA_PS657 0.00193038531326858 -0.190260938013028 0.00316157594614067 2 CDH3|P-CADHERIN 1.21329178766897e-06 -0.197598190139155 2.57514991668516e-06 2 CCND1|CYCLIN_D1 7.12371301466129e-09 -0.198330949665003 1.85216538381194e-08 2 YAP1|YAP 4.12246145870495e-10 -0.206090125919335 1.31918766678558e-09 2 MRE11A|MRE11 8.54657708229867e-24 -0.206582458749827 1.26266800435206e-22 2 CDH2|N-CADHERIN 1.25076226538825e-12 -0.215958797020929 4.73015547637738e-12 2 NRG1|HEREGULIN 7.55735414524621e-12 -0.218075087745114 2.5769338724774e-11 2 RAD51|RAD51 1.00658154759212e-08 -0.219876683895218 2.5532800231605e-08 2 AXL|AXL 0.00567949213118635 -0.220031544426094 0.00894950275217243 2 BID|BID 1.2160550501589e-17 -0.222137872473735 7.43939560097209e-17 2 PIK3R1 PIK3R2|PI3K-P85 1.35950502500725e-12 -0.226162080913791 5.04959009288407e-12 2 GATA6|GATA6 5.17183811643755e-05 -0.241465103653092 9.11646040863568e-05 2 MYC|C-MYC 1.25211890160323e-09 -0.243958404819265 3.61723238240933e-09 2 TIGAR|TIGAR 1.14566796613668e-22 -0.246468279443936 1.32388298309127e-21 2 STK11|LKB1 1.01818354291071e-29 -0.253272106525988 3.52970294875713e-28 2 YBX1|YB-1 3.79538724527674e-16 -0.27329304869702 1.91547900441781e-15 2 STAT3|STAT3_PY705 5.61863819322745e-10 -0.293148468888565 1.7707223396838e-09 2 ASNS|ASNS 7.00031141962508e-06 -0.308788525781705 1.37523375172606e-05 2 STMN1|STATHMIN 4.87279493149791e-28 -0.320800452612335 1.12615705083507e-26 2 WWTR1|TAZ 3.77390671831257e-37 -0.332483656012058 3.92486298704507e-35 2 G6PD|G6PD 8.14189437613071e-06 -0.333811004770894 1.58272339274317e-05 2 PEA15|PEA15 2.30113303856446e-21 -0.344320043463756 1.9943153000892e-20 2 BCL2L11|BIM 3.83239699928937e-14 -0.368990990530839 1.62681342010651e-13 2 ACVRL1|ACVRL1 1.00060878907155e-35 -0.375490645785586 5.20316570317206e-34 2 PREX1|PREX1 3.10269079147375e-17 -0.381593795530423 1.74421536385551e-16 2 LCK|LCK 1.3647906145388e-28 -0.497188622161192 4.05537782605815e-27 2 COL6A1|COLLAGEN_VI 4.35236941138121e-23 -0.513581304830215 5.65808023479557e-22 2 TGM2|TRANSGLUTAMINASE 8.7783635592547e-22 -0.554467100399584 8.2995437287499e-21 2 ANXA1|ANNEXIN-1 1.0974416468886e-13 -0.668920182771448 4.3897665875544e-13 2 HSPA1A|HSP70 4.93189926591549e-22 -0.694087172279002 4.8849287967163e-21 2 CASP7|CASPASE-7_CLEAVEDD198 3.23748840001528e-13 -0.75157883116036 1.24703256889477e-12 2 MYH11|MYH11 1.43709980104934e-06 -0.773097349779764 2.98916758618263e-06 2 RICTOR|RICTOR 1.54461439269906e-09 -0.835728787002495 4.40109306412883e-09 2 CAV1|CAVEOLIN-1 3.468563085046e-16 -0.872351115303811 1.80365280422392e-15 2 SERPINE1|PAI-1 1.04113934830797e-14 -0.89160780455939 4.70776053147952e-14 2 FN1|FIBRONECTIN 4.07482134095058e-28 -1.1521217365569 1.05945354864715e-26 2 CCNB1|CYCLIN_B1 9.45538736330832e-20 0.809755476835069 3.80718934531073e-18 3 CASP7|CASPASE-7_CLEAVEDD198 1.89410961751357e-08 0.75003088540921 1.19386303164492e-07 3 MSH6|MSH6 1.44912142441012e-16 0.652757331847998 2.15298040198075e-15 3 RPS6|S6 1.09822769576271e-19 0.63707117602214 3.80718934531073e-18 3 EIF4G1|EIF4G 3.38164860057652e-24 0.623997454184153 6.09783317134792e-22 3 RBM15|RBM15 1.01480734039603e-16 0.590444985745481 1.62369174463365e-15 3 TFRC|TFRC 5.3169047294551e-07 0.482625038019394 2.2569718035238e-06 3 GAPDH|GAPDH 4.33658431448168e-07 0.443540396320194 1.91916922853657e-06 3 SERPINE1|PAI-1 0.000893932756539308 0.433102614223055 0.00182292169960957 3 BCL2L11|BIM 4.81726347877232e-12 0.424600598742277 4.55450365265747e-11 3 SQSTM1|P62-LCK-LIGAND 2.51858642314872e-07 0.404845176049943 1.16414661336652e-06 3 SYK|SYK 8.83722290130962e-08 0.392868650422025 4.83721674598e-07 3 BRD4|BRD4 7.08319388986982e-06 0.387985897392857 2.67873514380531e-05 3 TUBA1B|ACETYL-A-TUBULIN-LYS40 0.000157374383252719 0.385124785225114 0.000389688949006733 3 RPS6KB1|P70S6K 9.53668744337737e-15 0.383467261401545 1.10201721567916e-13 3 DVL3|DVL3 4.95291500231128e-13 0.374408531336899 5.42213852884603e-12 3 EEF2K|EEF2K 2.05208442385965e-07 0.370053421192048 9.92636186425133e-07 3 STAT5A|STAT5-ALPHA 0.00016578388881713 0.351690337077403 0.000405682927928977 3 EIF4EBP1|4E-BP1 2.1957076541426e-10 0.350618608282551 1.90294663359025e-09 3 G6PD|G6PD 0.0040994160817805 0.347013527547082 0.00747963635973986 3 FOXM1|FOXM1 3.41756893824222e-09 0.335827026889188 2.29307851340123e-08 3 SLC1A5|SLC1A5 0.00866006113419936 0.334494707761905 0.0150107726326122 3 PCNA|PCNA 5.03813343345797e-17 0.332616783681751 8.73276461799381e-16 3 XRCC5|KU80 9.49630672411571e-08 0.317438776552231 5.06469691952838e-07 3 TP53BP1|53BP1 1.9041651386407e-07 0.317410068161156 9.43015116279204e-07 3 ASNS|ASNS 0.00024169499347947 0.31691270693976 0.000558583984930331 3 BAP1|BAP1-C-4 3.63642890870302e-12 0.30825382993484 3.60179625242966e-11 3 EEF2|EEF2 1.68253420097404e-09 0.301688360350858 1.20678315104345e-08 3 TSC2|TUBERIN 1.45242617525235e-06 0.290163679071796 6.04209288904978e-06 3 EGFR|EGFR 6.06136630774978e-05 0.286728504878089 0.000172707423563281 3 CCNE1|CYCLIN_E1 0.000148039015613114 0.266633432046053 0.000371151778682459 3 FN1|FIBRONECTIN 0.0100510989585415 0.261910298708867 0.0172779221766664 3 ANXA1|ANNEXIN-1 0.0198419108192403 0.254867261499828 0.0322431050812655 3 ACACA|ACC1 0.000290633036823811 0.249611697511499 0.00065708338760166 3 MSH2|MSH2 1.53817789719791e-07 0.246902500579462 7.80343908822354e-07 3 SMAD1|SMAD1 3.68980598618344e-10 0.243357504092506 2.98684356362229e-09 3 CCNE2|CYCLIN_E2 2.55150369651332e-09 0.233089547543993 1.7690425629159e-08 3 PARP1|PARP1 0.000345303860901973 0.231531035375428 0.000772292506103337 3 ITGA2|CD49B 0.00173947317949305 0.225978128236213 0.00344581353651957 3 CTNNB1|BETA-CATENIN 0.0274023857649102 0.222034973622254 0.0438438172238563 3 RAF1|C-RAF 2.42161886406377e-05 0.216270925220767 7.87026130820725e-05 3 PTEN|PTEN 0.000476813267872409 0.214042728399714 0.00103309541372355 3 BRCA2|BRCA2 2.48083030343289e-05 0.212123360511905 7.93865697098525e-05 3 GSK3A GSK3B|GSK3-ALPHA-BETA 2.75160563960069e-12 0.205867613535984 2.86166986518472e-11 3 ATM|ATM 0.0110560499243581 0.205345458757494 0.0188496588874302 3 PXN|PAXILLIN 0.00387049808553233 0.203682198623055 0.00718806787313147 3 AKT1 AKT2 AKT3|AKT 1.48733704115004e-05 0.201818975959668 5.07157548457719e-05 3 XRCC1|XRCC1 1.97134557428257e-08 0.200175182520652 1.20599964544345e-07 3 CHEK1|CHK1 2.84182715681274e-05 0.183638238924085 8.95606134268257e-05 3 MTOR|MTOR 4.13417328081587e-08 0.182550639171224 2.38863345113806e-07 3 NF2|NF2 5.27323391108076e-05 0.165388774791476 0.000152337868542333 3 CDH3|P-CADHERIN 0.0037153102355217 0.164337317608753 0.00702531389989558 3 MYH9|MYOSIN-IIA_PS1943 0.00399792485524057 0.156519707000515 0.0073590121229207 3 PEA15|PEA15 0.000218958363420703 0.151220522323741 0.000511722916758497 3 GAB2|GAB2 0.00669969040728098 0.149962494858066 0.0118096237687665 3 TSC1|TSC1 0.000132704532708984 0.147955718751659 0.000345031785043358 3 TIGAR|TIGAR 0.000410461775418514 0.140235214442048 0.000908255843479265 3 BRAF|B-RAF 0.0432422874785803 0.13971735912111 0.0656525240550708 3 YBX1|YB-1 4.85043780071203e-05 0.138073611180492 0.000142097332753254 3 BAK1|BAK 0.000135884192057274 0.135169298072025 0.000348937184542136 3 ERCC1|ERCC1 7.22068246835031e-06 0.131589907853947 2.68196777395869e-05 3 PIK3R1 PIK3R2|PI3K-P85 0.0018662716559872 0.11556476604754 0.00366211796646545 3 ARID1A|ARID1A 0.0430695958995738 0.11468614077381 0.0656525240550708 3 RPS6KA1|P90RSK 0.0171730542631665 0.102746442164359 0.0283491689423701 3 SETD2|SETD2 0.00653469975783519 0.102152524212529 0.0116172440139292 3 ADAR|ADAR1 9.59079248774056e-05 0.101152827460474 0.000259075952915589 3 ESR1|ER-ALPHA_PS118 1.7445956567167e-05 0.100060843657609 5.78059430862655e-05 3 LCK|LCK 0.0358739578467557 0.0983168258526888 0.0552724683861125 3 MAPK1|ERK2 0.00700283364954202 0.0918401459039474 0.0122402470513003 3 PIK3CA |PI3K-P110-ALPHA 0.000782209895924325 0.0908915708976545 0.0016269965835226 3 ERRFI1|MIG-6 0.000177230757081772 0.0904710504899886 0.000428651133407076 3 BIRC2 |CIAP 0.00331858592271222 0.0784792935221396 0.0063327144213224 3 MAPK9|JNK2 0.0317661457136541 0.0783030612921625 0.0504378496827485 3 YWHAB|14-3-3_BETA 0.0350545626575224 -0.0506112885485698 0.0544130524833184 3 STK11|LKB1 0.0347350004296478 -0.0512203081618421 0.054322406686968 3 RAF1|C-RAF_PS338 0.0134961376884291 -0.068026587600286 0.0226386825741391 3 PRKCD|PKC-DELTA_PS664 0.0255862146671106 -0.0692025941433066 0.0412552918663489 3 CDKN1B|P27_PT157 8.32267236905216e-05 -0.0704246558641304 0.000227778401679322 3 CTNNA1|ALPHA-CATENIN 0.0329357532526985 -0.0764006882415811 0.0518987627012219 3 PGR|PR 0.000148103834762712 -0.0772489409536041 0.000371151778682459 3 CHEK1|CHK1_PS345 0.019019602086979 -0.0838301498679062 0.0311502144416664 3 MRE11A|MRE11 1.75085308386285e-05 -0.086370109319508 5.78059430862655e-05 3 CDK1|CDK1 0.0063238381566389 -0.087697762969508 0.0113392960050077 3 COPS5|JAB1 0.0153518158905581 -0.0899170515543664 0.0255454216418887 3 SNAI1|SNAIL 0.00202380892975327 -0.0986783454176773 0.00393413324662318 3 CDKN1B|P27 0.0037613396610276 -0.102020762773741 0.00704827612156523 3 BCL2|BCL-2 0.00570668054606008 -0.104132540551659 0.0103216482920043 3 JUN|C-JUN_PS73 0.000814256853215236 -0.106752704524428 0.00167688540068088 3 ARAF|A-RAF_PS299 0.000457285208314445 -0.108424397139989 0.00100121392978321 3 PECAM1|CD31 0.0021998955546293 -0.108958199456465 0.00423683588298976 3 RB1|RB 4.21373537121538e-07 -0.118834663311384 1.90534121133217e-06 3 CDH2|N-CADHERIN 0.000274214997978312 -0.11999755577992 0.000626777138236142 3 ACVRL1|ACVRL1 3.63527973072053e-05 -0.121532496979691 0.000112856445371622 3 RAB11A RAB11B|RAB11 5.99030449250456e-06 -0.123800904554062 2.35091195177537e-05 3 BAD|BAD_PS112 0.000534624812890865 -0.127238051463101 0.00113586521530203 3 RICTOR|RICTOR_PT1135 4.9944010445402e-07 -0.130641306870194 2.16424045263409e-06 3 AKT1S1|PRAS40_PT246 3.73355445452786e-10 -0.131082958369737 2.98684356362229e-09 3 SRSF1|SF2 0.000108112333192807 -0.133157404961499 0.000284650193722834 3 BECN1|BECLIN 5.56646610876479e-06 -0.135905032509668 2.22658644350592e-05 3 MET|C-MET 3.83638720302197e-06 -0.138839009523741 1.56464419260504e-05 3 DIRAS3|ARHI 4.055139041826e-08 -0.14197550294651 2.38863345113806e-07 3 MTOR|MTOR_PS2448 1.05907516223533e-05 -0.148307348692849 3.7336887075415e-05 3 ESR1|ER-ALPHA 9.74949768734168e-05 -0.167235701728776 0.000259986604995778 3 RPS6KB1|P70S6K_PT389 2.1549695263503e-07 -0.184540016087586 1.01871286700196e-06 3 MAP2K1|MEK1_PS217_S221 8.24237425339727e-10 -0.19094556773587 6.12290658823797e-09 3 CCND1|CYCLIN_D1 8.56701791017358e-06 -0.194648928218707 3.12608711898343e-05 3 RPS6KA1|P90RSK_PT359_S363 5.07401001323031e-10 -0.195870392031064 3.9088669731552e-09 3 GATA6|GATA6 0.000985884884638804 -0.210414173714286 0.00199091316509584 3 FOXO3|FOXO3A_PS318_S321 3.26709501718488e-15 -0.219631841624657 3.99738684455562e-14 3 ERBB2|HER2_PY1248 3.69238000267885e-05 -0.225620200416304 0.000112943388317235 3 TSC2|TUBERIN_PT1462 2.67578907340273e-19 -0.235745198352346 7.95091610382526e-18 3 INPP4B|INPP4B 0.0124511836686327 -0.238238381263673 0.0210556601876065 3 MAPK8|JNK_PT183_PY185 4.88528032369568e-19 -0.245832413043535 1.27017288416088e-17 3 NFKB1|NF-KB-P65_PS536 0.000182363338836886 -0.249337776591934 0.00043599510894336 3 SRC|SRC 0.000213416071404093 -0.249409729144336 0.000504437986955129 3 IGFBP2|IGFBP2 0.00129620150691639 -0.249861528845709 0.00259240301383278 3 PRKCB|PKC-PAN_BETAII_PS660 8.71697369716533e-06 -0.253773933843535 3.12608711898343e-05 3 COL6A1|COLLAGEN_VI 1.17078412468776e-05 -0.268132459268249 4.05871829891757e-05 3 HSPA1A|HSP70 0.000535167264901918 -0.274253406963673 0.00113586521530203 3 EGFR|EGFR_PY1068 7.78663444445657e-05 -0.285786789039188 0.000215949328592929 3 KIT|C-KIT 5.71216364958211e-09 -0.320415282741133 3.71290637222837e-08 3 YAP1|YAP_PS127 4.23064154090896e-05 -0.358710372296396 0.000125710491501295 3 CAV1|CAVEOLIN-1 0.00076132770927734 -0.393574643027174 0.00159955720737057 3 RB1|RB_PS807_S811 6.42512201511627e-06 -0.393664700210698 2.47486181322997e-05 3 AKT1 AKT2 AKT3|AKT_PT308 4.44180777516134e-16 -0.440849249302689 6.15930678155706e-15 3 EIF4EBP1|4E-BP1_PT37_T46 1.00681667767358e-07 -0.481427084390561 5.23544672390262e-07 3 CDKN1A|P21 5.26870263809437e-08 -0.521442574620881 2.96186526682062e-07 3 PDCD4|PDCD4 1.22858961191393e-10 -0.53344132735246 1.11107234468738e-09 3 AKT1 AKT2 AKT3|AKT_PS473 1.72709884310742e-17 -0.536732340540675 3.59236559366343e-16 3 RICTOR|RICTOR 6.61736983815267e-05 -0.553232715424771 0.000186001746802129 3 SRC|SRC_PY416 8.00805675727596e-21 -0.565239531607723 4.1641895137835e-19 3 GSK3A GSK3B|GSK3_PS9 1.09492949458899e-18 -0.600859780022368 2.53050372082789e-17 3 GSK3A GSK3B|GSK3-ALPHA-BETA_PS21_S9 1.45603008462774e-15 -0.636712819793535 1.89283911001606e-14 3 MAPK1 MAPK3|MAPK_PT202_Y204 5.86330112629608e-24 -0.687567288363444 6.09783317134792e-22 3 MAPK14|P38_PT180_Y182 3.89027079327918e-17 -0.77360184930738 7.35614840910972e-16 3 MYH11|MYH11 3.82306006988822e-05 -0.802107950625572 0.000115245868773442 3 SRC|SRC_PY527 4.50926252214265e-23 -1.03465554565051 3.12642201535224e-21 3