Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.044 0.237 0.588 2.0 -0.556 74.0 76.0 IHH 0.021 0.074 -9999.0 0.0 -0.198 1.0 1.0 SHH Np/Cholesterol/GAS1 -0.068 0.148 -9999.0 0.0 -0.314 128.0 128.0 LRPAP1 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.068 0.147 0.312 128.0 -9999.0 0.0 128.0 SMO/beta Arrestin2 -0.001 0.185 0.41 2.0 -0.489 27.0 29.0 SMO -0.016 0.183 0.442 2.0 -0.511 27.0 29.0 AKT1 -0.02 0.191 -9999.0 0.0 -0.6 36.0 36.0 ARRB2 0.031 0.01 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.091 0.237 -9999.0 0.0 -0.543 111.0 111.0 ADRBK1 0.032 0.01 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.015 0.181 0.44 2.0 -0.503 27.0 29.0 STIL 0.041 0.149 0.387 16.0 -0.366 4.0 20.0 DHH N/PTCH2 0.05 0.01 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 0.006 0.161 0.377 2.0 -0.435 23.0 25.0 PIK3CA 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.034 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.111 0.392 0.664 2.0 -0.902 94.0 96.0 determination of left/right symmetry -0.015 0.181 0.44 2.0 -0.503 27.0 29.0 PIK3R1 -0.02 0.166 -9999.0 0.0 -0.543 47.0 47.0 skeletal system development -0.109 0.387 0.663 2.0 -0.89 94.0 96.0 IHH N/Hhip 0.038 0.052 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/Hhip 0.05 0.011 -9999.0 0.0 -9999.0 0.0 0.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.015 0.181 0.44 2.0 -0.503 27.0 29.0 pancreas development 0.034 0.011 -9999.0 0.0 -9999.0 0.0 0.0 HHAT 0.024 0.059 -9999.0 0.0 -0.543 5.0 5.0 PI3K 0.005 0.127 -9999.0 0.0 -0.38 48.0 48.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.144 0.266 -9999.0 0.0 -0.543 158.0 158.0 somite specification -0.015 0.181 0.44 2.0 -0.503 27.0 29.0 SHH Np/Cholesterol/PTCH1 -0.009 0.122 -9999.0 0.0 -0.379 8.0 8.0 SHH Np/Cholesterol/PTCH2 0.024 0.037 -9999.0 0.0 -0.311 5.0 5.0 SHH Np/Cholesterol/Megalin -0.055 0.145 -9999.0 0.0 -0.32 110.0 110.0 SHH 0.011 0.043 -9999.0 0.0 -0.399 5.0 5.0 catabolic process -0.009 0.174 0.463 2.0 -0.481 23.0 25.0 SMO/Vitamin D3 0.01 0.171 0.408 15.0 -0.463 12.0 27.0 SHH Np/Cholesterol/Hhip 0.025 0.038 -9999.0 0.0 -0.311 5.0 5.0 LRP2 -0.119 0.254 -9999.0 0.0 -0.543 136.0 136.0 receptor-mediated endocytosis -0.061 0.195 0.347 8.0 -0.513 37.0 45.0 SHH Np/Cholesterol/BOC -0.038 0.13 -9999.0 0.0 -0.312 87.0 87.0 SHH Np/Cholesterol/CDO 0.02 0.049 -9999.0 0.0 -0.351 7.0 7.0 mesenchymal cell differentiation -0.025 0.038 0.309 5.0 -9999.0 0.0 5.0 mol:Vitamin D3 0.027 0.158 0.412 16.0 -0.38 8.0 24.0 IHH N/PTCH2 0.038 0.051 -9999.0 0.0 -9999.0 0.0 0.0 CDON 0.027 0.045 -9999.0 0.0 -0.543 3.0 3.0 IHH N/PTCH1 -0.0 0.179 0.466 2.0 -0.472 25.0 27.0 Megalin/LRPAP1 -0.071 0.198 -9999.0 0.0 -0.399 136.0 136.0 PTCH2 0.034 0.006 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol 0.014 0.034 -9999.0 0.0 -0.309 5.0 5.0 PTCH1 -0.009 0.174 0.463 2.0 -0.483 23.0 25.0 HHIP 0.034 0.011 -9999.0 0.0 -9999.0 0.0 0.0