rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 99 AKT1(2), AKT2(4), AKT3(5), CASP8(10), CD14(1), CD40(2), CD86(4), CHUK(7), CXCL10(1), IFNA1(1), IFNA10(3), IFNA13(3), IFNA14(3), IFNA16(2), IFNA17(3), IFNA2(3), IFNA21(4), IFNA4(2), IFNA6(1), IFNA7(2), IFNA8(2), IFNAR1(2), IFNAR2(1), IKBKB(5), IKBKE(6), IL12B(2), IL6(1), IRAK1(3), IRAK4(3), IRF3(6), IRF5(2), JUN(3), LBP(1), LY96(1), MAP2K1(5), MAP2K2(2), MAP2K3(3), MAP2K4(32), MAP2K6(1), MAP2K7(1), MAP3K7(3), MAP3K8(4), MAPK1(1), MAPK10(4), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8(2), MAPK9(1), MYD88(1), NFKB1(5), NFKB2(5), NFKBIA(3), PIK3CA(351), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R1(15), PIK3R2(4), PIK3R3(3), PIK3R5(5), RELA(3), RIPK1(5), SPP1(2), STAT1(4), TBK1(1), TICAM1(2), TIRAP(1), TLR1(3), TLR2(3), TLR3(7), TLR4(15), TLR5(4), TLR7(9), TLR8(13), TLR9(2), TRAF3(3), TRAF6(4) 125201952 655 451 351 72 39 212 66 246 89 3 <1.00e-15 <1.00e-15 <1.87e-14 2 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 49 ACOX1(3), APOA1(3), CD36(4), CITED2(2), CPT1B(4), CREBBP(15), DUSP1(1), DUT(1), EHHADH(4), EP300(13), FABP1(2), HSD17B4(8), JUN(3), LPL(1), MAPK1(1), MAPK3(1), MRPL11(1), MYC(1), NCOA1(5), NCOR1(41), NCOR2(8), NFKBIA(3), NR0B2(2), NR1H3(2), NR2F1(1), NRIP1(10), PIK3CA(351), PIK3R1(15), PPARA(4), PRKACB(1), PRKACG(3), PRKAR1A(4), PRKAR2A(2), PRKAR2B(2), PRKCA(4), PTGS2(6), RB1(22), RELA(3), RXRA(2), SP1(6), STAT5A(6), STAT5B(5) 88375670 576 422 274 52 34 180 46 217 97 2 <1.00e-15 <1.00e-15 <1.87e-14 3 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 41 APAF1(11), BAK1(3), BAX(3), BCL2L1(1), BID(3), BIRC2(3), BIRC3(4), CASP2(3), CASP3(1), CASP6(2), CASP7(2), CASP8(10), CASP9(2), FAS(1), FASLG(2), JUN(3), MAP2K4(32), MAP3K1(80), MAPK10(4), MCL1(1), MDM2(3), MYC(1), NFKB1(5), NFKBIA(3), PARP1(6), PRF1(2), RELA(3), RIPK1(5), TNFRSF1A(4), TNFRSF1B(2), TP53(299), TRAF1(2), TRAF2(1) 52249364 507 420 356 22 66 60 64 87 212 18 <1.00e-15 <1.00e-15 <1.87e-14 4 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 33 AKT1(2), AKT2(4), AKT3(5), BCR(3), BTK(7), CD19(6), CDKN2A(1), DAPP1(2), FLOT1(2), FLOT2(2), GAB1(2), ITPR1(15), ITPR2(18), ITPR3(14), LYN(6), NR0B2(2), PDK1(2), PHF11(3), PIK3CA(351), PITX2(5), PLCG2(8), PPP1R13B(4), PREX1(9), PTEN(35), PTPRC(8), RPS6KA1(6), RPS6KA2(5), RPS6KA3(8), RPS6KB1(4), SAG(3), SYK(4), TEC(6), VAV1(6) 79116874 558 414 255 45 41 179 43 231 63 1 <1.00e-15 <1.00e-15 <1.87e-14 5 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(3), EGF(5), EGFR(5), ELK1(4), HRAS(2), JAK1(11), JUN(3), MAP2K1(5), MAP2K4(32), MAP3K1(80), MAPK3(1), MAPK8(2), PIK3CA(351), PIK3R1(15), PLCG1(8), PRKCA(4), RAF1(4), RASA1(2), SHC1(2), SOS1(5), SRF(1), STAT1(4), STAT3(5), STAT5A(6) 53850802 560 408 248 33 24 158 39 217 103 19 <1.00e-15 <1.00e-15 <1.87e-14 6 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 48 AKT1(2), AKT2(4), AKT3(5), BRD4(3), CAP1(2), CBL(4), CDKN2A(1), F2RL2(2), FLOT1(2), FLOT2(2), GSK3A(5), GSK3B(2), INPPL1(6), IRS1(4), IRS4(7), LNPEP(2), MAPK1(1), MAPK3(1), PARD3(8), PARD6A(1), PDK1(2), PIK3CA(351), PIK3CD(6), PIK3R1(15), PTEN(35), RAF1(4), RPS6KA1(6), RPS6KA2(5), RPS6KA3(8), RPS6KB1(4), SERPINB6(2), SFN(1), SHC1(2), SLC2A4(1), SORBS1(7), SOS1(5), SOS2(6), YWHAB(2), YWHAG(1), YWHAZ(3) 80302320 530 406 227 52 31 178 32 221 65 3 1.19e-14 <1.00e-15 <1.87e-14 7 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 35 ACTA1(3), CRK(1), CRKL(1), DOCK1(8), ELK1(4), GAB1(2), HGF(5), HRAS(2), ITGA1(6), ITGB1(5), JUN(3), MAP2K1(5), MAP2K2(2), MAP4K1(6), MAPK1(1), MAPK3(1), MAPK8(2), MET(10), PAK1(3), PIK3CA(351), PIK3R1(15), PTEN(35), PTK2(7), PTK2B(6), PTPN11(1), RAF1(4), RAP1A(2), RAP1B(1), RASA1(2), SOS1(5), SRC(1), STAT3(5) 65385720 505 394 203 43 28 168 39 212 55 3 <1.00e-15 <1.00e-15 <1.87e-14 8 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 38 AKT1(2), AKT2(4), AKT3(5), BAD(1), BCR(3), BLNK(1), BTK(7), CD19(6), DAG1(2), EPHB2(5), ITPKA(1), ITPKB(8), LYN(6), MAP2K1(5), MAP2K2(2), MAPK1(1), NFAT5(7), NFKB1(5), NFKB2(5), NFKBIA(3), NFKBIB(1), NFKBIE(2), PI3(1), PIK3CA(351), PIK3CD(6), PIK3R1(15), PLCG2(8), PPP1R13B(4), RAF1(4), SERPINA4(4), SHC1(2), SOS1(5), SOS2(6), SYK(4), VAV1(6) 72377320 498 393 199 42 31 171 38 216 41 1 <1.00e-15 <1.00e-15 <1.87e-14 9 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 33 AKT1(2), AKT2(4), AKT3(5), BAD(1), BTK(7), CDKN2A(1), DAPP1(2), GSK3A(5), GSK3B(2), IARS(8), INPP5D(4), PDK1(2), PIK3CA(351), PPP1R13B(4), PTEN(35), RPS6KA1(6), RPS6KA2(5), RPS6KA3(8), RPS6KB1(4), SFN(1), SHC1(2), SOS1(5), SOS2(6), TEC(6), YWHAB(2), YWHAG(1), YWHAZ(3) 51274772 482 379 180 27 23 165 31 205 57 1 <1.00e-15 <1.00e-15 <1.87e-14 10 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 INPP1(1), INPP4A(5), INPP4B(7), INPP5A(1), INPPL1(6), ITPKA(1), ITPKB(8), OCRL(8), PIK3C2A(5), PIK3C2B(12), PIK3C2G(8), PIK3CA(351), PIK3CB(8), PIK3CG(5), PLCB1(12), PLCB2(7), PLCB3(2), PLCB4(15), PLCD1(3), PLCG1(8), PLCG2(8) 64214840 481 376 182 33 26 172 33 204 45 1 <1.00e-15 <1.00e-15 <1.87e-14 11 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 32 DUSP1(1), GORASP1(1), MAP2K4(32), MAP2K7(1), MAPK1(1), MAPK10(4), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(8), MAPK9(1), NFKB1(5), NFKB2(5), NFKBIA(3), NFKBIB(1), NFKBIE(2), PIK3CA(351), PIK3CD(6), PIK3R1(15), SYT1(1), TRAF2(1), TRAF3(3), TRAF5(3), TRAF6(4) 45041575 457 376 154 23 24 149 31 200 51 2 <1.00e-15 <1.00e-15 <1.87e-14 12 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 AKT1(2), EIF4A1(2), EIF4A2(10), EIF4B(2), EIF4G1(9), EIF4G2(2), EIF4G3(5), MKNK1(2), PDK2(1), PDPK1(2), PIK3CA(351), PIK3R1(15), PPP2CA(3), PTEN(35), RPS6(4), RPS6KB1(4), TSC1(5), TSC2(6) 39508578 460 374 157 23 16 164 25 204 49 2 <1.00e-15 <1.00e-15 <1.87e-14 13 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 25 AKT1(2), AKT2(4), AKT3(5), BAD(1), GSK3A(5), GSK3B(2), IL4R(6), IRS1(4), JAK1(11), JAK3(8), MAP4K1(6), MAPK1(1), MAPK3(1), PDK1(2), PIK3CA(351), PIK3CD(6), PIK3R1(15), PPP1R13B(4), RAF1(4), SHC1(2), SOS1(5), SOS2(6), STAT6(7) 49070630 458 371 159 32 19 157 34 207 40 1 <1.00e-15 <1.00e-15 <1.87e-14 14 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 24 GHR(5), HRAS(2), INSR(11), IRS1(4), JAK2(7), MAP2K1(5), MAPK1(1), MAPK3(1), PIK3CA(351), PIK3R1(15), PLCG1(8), PRKCA(4), RAF1(4), RPS6KA1(6), SHC1(2), SLC2A4(1), SOS1(5), SRF(1), STAT5A(6), STAT5B(5) 46448055 444 369 144 28 19 163 24 200 37 1 <1.00e-15 <1.00e-15 <1.87e-14 15 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT1(2), AKT2(4), AKT3(5), CISH(2), IARS(8), IL13RA1(1), IL2RG(2), IL4(1), IL4R(6), INPP5D(4), JAK1(11), JAK2(7), JAK3(8), NR0B2(2), PI3(1), PIK3CA(351), PPP1R13B(4), RPS6KB1(4), SERPINA4(4), SHC1(2), SOS1(5), SOS2(6), SRC(1), STAT6(7), TYK2(7) 52139137 455 368 155 32 21 157 35 200 41 1 <1.00e-15 <1.00e-15 <1.87e-14 16 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 BCAR1(6), CRK(1), CXCR4(3), GNAI1(2), GNAQ(1), GNB1(2), HRAS(2), MAP2K1(5), MAPK1(1), MAPK3(1), NFKB1(5), PIK3C2G(8), PIK3CA(351), PIK3R1(15), PLCG1(8), PRKCA(4), PTK2(7), PTK2B(6), RAF1(4), RELA(3) 39926402 435 367 135 21 18 156 26 203 30 2 <1.00e-15 <1.00e-15 <1.87e-14 17 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 33 AKT1(2), BAD(1), BCL2L1(1), CBL(4), CFLAR(1), CRKL(1), E2F1(5), HRAS(2), IL2RA(2), IL2RB(3), IL2RG(2), IRS1(4), JAK1(11), JAK3(8), MAPK1(1), MAPK3(1), MYC(1), NMI(2), PIK3CA(351), PIK3R1(15), RAF1(4), RPS6KB1(4), SHC1(2), SOS1(5), STAT5A(6), STAT5B(5), SYK(4) 49818802 448 365 149 29 20 156 31 205 35 1 <1.00e-15 <1.00e-15 <1.87e-14 18 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 ADCY1(5), AKT1(2), CAMK2A(3), CAMK2B(2), CAMK2D(4), CAMK2G(2), CREB1(1), GNAS(11), HRAS(2), MAPK1(1), MAPK14(1), MAPK3(1), PIK3CA(351), PIK3R1(15), PRKACB(1), PRKACG(3), PRKAR1A(4), PRKAR2A(2), PRKAR2B(2), PRKCA(4), RPS6KA1(6), RPS6KA5(4), SOS1(5) 40783621 432 364 132 32 21 151 29 199 31 1 <1.00e-15 <1.00e-15 <1.87e-14 19 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 AKT1(2), AKT2(4), AKT3(5), BPNT1(2), ILK(3), MAPK1(1), MAPK3(1), PDK1(2), PIK3CA(351), PIK3CD(6), PTEN(35), PTK2B(6), SHC1(2), SOS1(5) 28521469 425 360 124 15 11 148 25 197 43 1 <1.00e-15 <1.00e-15 <1.87e-14 20 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(5), ARHGEF1(10), F2(2), F2R(4), GNA12(2), GNA13(1), GNAI1(2), GNAQ(1), GNB1(2), MAP3K7(3), PIK3CA(351), PIK3R1(15), PLCB1(12), PPP1R12B(4), PRKCA(4), PTK2B(6), ROCK1(8) 36538502 432 355 133 27 19 150 31 196 35 1 <1.00e-15 <1.00e-15 <1.87e-14 21 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 AKT1(2), CREB1(1), HRAS(2), MAPK1(1), MAPK3(1), MAPK7(4), MEF2A(6), MEF2C(4), MEF2D(3), NTRK1(8), PIK3CA(351), PIK3R1(15), PLCG1(8), RPS6KA1(6), SHC1(2) 27732748 414 353 114 18 17 146 21 201 28 1 <1.00e-15 <1.00e-15 <1.87e-14 22 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 AKT1(2), BAD(1), BCL2L1(1), CASP9(2), CHUK(7), ELK1(4), HRAS(2), MAP2K1(5), MAPK3(1), NFKB1(5), PIK3CA(351), PIK3R1(15), RAF1(4), RALA(1), RALBP1(3), RALGDS(1), RELA(3), RHOA(6) 27461026 414 353 114 23 17 152 23 199 22 1 <1.00e-15 <1.00e-15 <1.87e-14 23 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 AKT1(2), HRAS(2), KLK2(3), NTRK1(8), PIK3CA(351), PIK3R1(15), PLCG1(8), PRKCA(4), SHC1(2), SOS1(5) 22216225 400 348 101 18 11 143 23 195 27 1 <1.00e-15 <1.00e-15 <1.87e-14 24 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 ADCY1(5), AKT1(2), ASAH1(1), GNAI1(2), GNB1(2), ITGAV(7), ITGB3(4), MAPK1(1), MAPK3(1), PDGFRA(6), PIK3CA(351), PIK3R1(15), PLCB1(12), PRKCA(4), PTK2(7), SMPD1(2), SPHK1(1), SRC(1) 38814098 424 347 125 24 22 149 23 199 30 1 <1.00e-15 <1.00e-15 <1.87e-14 25 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 16 CD28(2), CD3E(3), CD3G(3), CD86(4), CTLA4(1), HLA-DRB1(10), ICOS(3), ITK(7), LCK(2), PIK3CA(351), PIK3R1(15), PTPN11(1) 17765323 402 345 103 21 7 150 27 194 23 1 <1.00e-15 <1.00e-15 <1.87e-14 26 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 AKT1(2), BAD(1), HRAS(2), IGF1R(7), IRS1(4), MAP2K1(5), MAPK1(1), MAPK3(1), PIK3CA(351), PIK3R1(15), RAF1(4), SHC1(2), SOS1(5) 26135337 400 344 101 17 9 149 21 195 25 1 <1.00e-15 <1.00e-15 <1.87e-14 27 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 AKT1(2), BAD(1), CASP9(2), CHUK(7), GHR(5), NFKB1(5), NFKBIA(3), PDPK1(2), PIK3CA(351), PIK3R1(15), PPP2CA(3), RELA(3) 20173457 399 341 100 17 13 149 23 190 23 1 <1.00e-15 <1.00e-15 <1.87e-14 28 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 16 APAF1(11), ATM(23), BAX(3), CCND1(1), CCNE1(2), CDK2(2), CDK4(1), CDKN1A(1), E2F1(5), MDM2(3), RB1(22), TIMP3(3), TP53(299) 26118523 376 338 236 16 55 38 44 78 161 0 <1.00e-15 <1.00e-15 <1.87e-14 29 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ACTR2(2), ACTR3(2), ARPC1A(3), ARPC1B(2), ARPC2(5), PAK1(3), PDGFRA(6), PIK3CA(351), PIK3R1(15), WASL(4) 19606623 393 337 94 19 9 151 20 187 25 1 <1.00e-15 <1.00e-15 <1.87e-14 30 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 12 ATM(23), CDC25A(1), CDC25B(3), CDC25C(4), CDK2(2), CDK4(1), CHEK1(2), MYT1(10), RB1(22), TP53(299), WEE1(4) 25802354 371 336 231 14 51 41 43 79 157 0 <1.00e-15 <1.00e-15 <1.87e-14 31 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 15 ARF1(2), CCND1(1), CDK2(2), CDK4(1), CDKN1A(1), CDKN1B(10), CDKN2A(1), CFL1(1), E2F1(5), E2F2(1), MDM2(3), PRB1(3), TP53(299) 11171450 330 321 190 9 50 23 40 70 145 2 <1.00e-15 <1.00e-15 <1.87e-14 32 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 9 CHUK(7), DNAJC3(4), EIF2S1(3), EIF2S2(3), NFKB1(5), NFKBIA(3), RELA(3), TP53(299) 14502112 327 309 189 8 55 31 42 69 130 0 <1.00e-15 <1.00e-15 <1.87e-14 33 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 27 ARHGDIB(1), BAG4(1), CASP2(3), CASP3(1), CASP8(10), DFFA(4), DFFB(2), JUN(3), LMNA(4), LMNB1(2), LMNB2(3), MADD(15), MAP2K4(32), MAP3K1(80), MAP3K7(3), MAPK8(2), PAK1(3), PAK2(2), PRKDC(24), RB1(22), RIPK1(5), SPTAN1(12), TNFRSF1A(4), TRAF2(1) 56207789 239 192 224 22 23 33 28 28 109 18 0.000417 <1.00e-15 <1.87e-14 34 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 ADCY1(5), AKT1(2), BAD(1), BAX(3), BCL2L1(1), CSF2RB(4), IGF1R(7), IL3(1), IL3RA(3), KIT(8), KITLG(3), PIK3CA(351), PIK3R1(15), PRKACB(1), PRKACG(3), PRKAR1A(4), PRKAR2A(2), PRKAR2B(2) 30866674 416 345 117 24 13 155 25 192 30 1 <1.00e-15 1.11e-15 2.01e-14 35 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 7 HDAC1(6), MAX(2), MYC(1), SP1(6), SP3(7), TP53(299), WT1(3) 9828997 324 310 185 9 50 27 40 73 134 0 <1.00e-15 1.22e-15 2.15e-14 36 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 AKT1(2), CREB1(1), MAP2K1(5), MAP2K2(2), MAP2K3(3), MAP2K6(1), MAP3K1(80), MAPK1(1), MAPK14(1), MAPK3(1), NFKB1(5), PIK3CA(351), PIK3R1(15), RB1(22), RELA(3), SP1(6) 28315648 499 393 191 19 13 151 29 204 83 19 <1.00e-15 1.44e-15 2.40e-14 37 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 ACTR2(2), ACTR3(2), AKT1(2), ANGPTL2(1), DAG1(2), DGKA(2), ITGA9(7), ITPKA(1), ITPKB(8), ITPR1(15), ITPR2(18), ITPR3(14), MAP2K1(5), MAPK1(1), MAPK3(1), NR1I3(2), PAK1(3), PDE3A(12), PDE3B(4), PI3(1), PIK3C2G(8), PIK3CA(351), PIK3CD(6), PIK3R1(15), RIPK3(4), RPS4X(2), SGCB(2) 70380226 491 384 190 48 24 174 31 220 41 1 1.14e-14 1.44e-15 2.40e-14 38 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 CSNK2A1(3), ELK1(4), HRAS(2), JUN(3), KLK2(3), MAP2K1(5), MAPK3(1), MAPK8(2), NGFR(1), PIK3CA(351), PIK3R1(15), PLCG1(8), RAF1(4), SHC1(2), SOS1(5) 26747300 409 350 110 22 15 146 21 197 29 1 <1.00e-15 1.78e-15 2.74e-14 39 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 17 ABCB1(9), AKT1(2), ATM(23), BAX(3), CDKN1A(1), CPB2(4), CSNK1A1(3), FHL2(2), HIF1A(4), MAPK8(2), MDM2(3), NFKBIB(1), NQO1(1), TP53(299) 28484779 357 329 218 26 53 41 44 78 141 0 8.87e-11 1.78e-15 2.74e-14 40 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 13 CREBBP(15), DAXX(2), HRAS(2), PAX3(3), PML(1), RARA(1), RB1(22), SIRT1(2), SP100(7), TNFRSF1A(4), TNFRSF1B(2), TP53(299) 25975215 360 323 220 19 56 34 45 76 149 0 <1.00e-15 1.78e-15 2.74e-14 41 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 42 CALM2(1), CD3E(3), CD3G(3), ELK1(4), HRAS(2), JUN(3), LAT(1), LCK(2), MAP2K1(5), MAP2K4(32), MAP3K1(80), MAPK3(1), MAPK8(2), NFATC1(5), NFATC2(4), NFATC3(7), NFATC4(6), NFKB1(5), NFKBIA(3), PIK3CA(351), PIK3R1(15), PLCG1(8), PPP3CA(5), PPP3CB(2), PRKCA(4), PTPN7(2), RAF1(4), RASA1(2), RELA(3), SHC1(2), SOS1(5), SYT1(1), VAV1(6), ZAP70(3) 67047760 582 423 271 50 31 168 43 217 104 19 <1.00e-15 1.89e-15 2.84e-14 42 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 CSNK2A1(3), ELK1(4), HRAS(2), INSR(11), IRS1(4), JUN(3), MAP2K1(5), MAPK3(1), MAPK8(2), PIK3CA(351), PIK3R1(15), PTPN11(1), RAF1(4), RASA1(2), SHC1(2), SLC2A4(1), SOS1(5), SRF(1) 35580299 417 349 118 25 13 153 22 198 30 1 <1.00e-15 2.11e-15 3.09e-14 43 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 38 AKT1(2), ATF2(4), DLD(1), DUSP10(9), DUSP4(1), GAB1(2), GCK(3), IL1R1(1), JUN(3), MAP2K4(32), MAP2K5(1), MAP2K7(1), MAP3K1(80), MAP3K10(3), MAP3K12(7), MAP3K13(10), MAP3K2(3), MAP3K3(1), MAP3K4(8), MAP3K5(12), MAP3K7(3), MAP3K9(5), MAPK10(4), MAPK7(4), MAPK8(2), MAPK9(1), MYEF2(3), NFATC3(7), NR2C2(1), PAPPA(13), SHC1(2), TP53(299), TRAF6(4), ZAK(4) 70700521 536 437 384 34 70 55 62 101 230 18 <1.00e-15 2.22e-15 3.11e-14 44 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 7 ATM(23), ATR(13), CDC25C(4), CHEK1(2), CHEK2(5), TP53(299) 23224924 346 325 207 12 51 38 42 77 138 0 <1.00e-15 2.22e-15 3.11e-14 45 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 20 AKT1(2), APAF1(11), ATM(23), BAD(1), BAX(3), BCL2L1(1), BID(3), CASP3(1), CASP6(2), CASP7(2), CASP9(2), EIF2S1(3), PRKCA(4), PTK2(7), STAT1(4), TLN1(15), TP53(299) 39687963 383 338 244 21 56 55 48 78 146 0 <1.00e-15 2.44e-15 3.34e-14 46 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(3), ELK1(4), HRAS(2), JAK1(11), JUN(3), MAP2K1(5), MAP2K4(32), MAP3K1(80), MAPK3(1), MAPK8(2), PDGFRA(6), PIK3CA(351), PIK3R1(15), PLCG1(8), PRKCA(4), RAF1(4), RASA1(2), SHC1(2), SOS1(5), SRF(1), STAT1(4), STAT3(5), STAT5A(6) 50158644 556 406 245 30 24 161 37 213 102 19 <1.00e-15 2.55e-15 3.35e-14 47 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 ADRB2(2), AKT1(2), ANXA1(5), CALM2(1), GNAS(11), GNB1(2), NFKB1(5), NOS3(3), NPPA(1), NR3C1(3), PIK3CA(351), PIK3R1(15), RELA(3), SYT1(1) 24837840 405 352 106 16 16 146 22 194 26 1 <1.00e-15 2.55e-15 3.35e-14 48 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT1(2), AKT2(4), AKT3(5), BAD(1), BCR(3), BLNK(1), BTK(7), CD19(6), CD22(5), CR2(5), DAG1(2), FLOT1(2), FLOT2(2), GSK3A(5), GSK3B(2), INPP5D(4), ITPR1(15), ITPR2(18), ITPR3(14), LYN(6), MAP4K1(6), MAPK1(1), MAPK3(1), NFATC1(5), NFATC2(4), NR0B2(2), PDK1(2), PIK3CA(351), PIK3CD(6), PIK3R1(15), PLCG2(8), PPP1R13B(4), PPP3CA(5), PPP3CB(2), PTPRC(8), RAF1(4), SHC1(2), SOS1(5), SOS2(6), SYK(4), VAV1(6) 103329099 556 407 256 64 40 186 44 240 45 1 4.79e-14 2.78e-15 3.54e-14 49 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 AKT1(2), EIF2B5(4), EIF2S1(3), EIF2S2(3), EIF2S3(2), GSK3B(2), IGF1R(7), INPPL1(6), PDK2(1), PDPK1(2), PIK3CA(351), PIK3R1(15), PPP2CA(3), PTEN(35), RPS6(4), RPS6KB1(4) 28113858 444 365 142 23 11 158 27 198 47 3 <1.00e-15 2.89e-15 3.54e-14 50 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 16 ABL1(6), CDKN2A(1), E2F1(5), MDM2(3), MYC(1), PIK3CA(351), PIK3R1(15), POLR1A(10), POLR1B(4), POLR1C(2), POLR1D(4), RB1(22), TBX2(1), TP53(299), TWIST1(2) 27727729 726 567 288 24 58 168 61 263 175 1 <1.00e-15 3.00e-15 3.54e-14 51 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 AKT1(2), BCAR1(6), CDKN1B(10), ILK(3), ITGB1(5), MAPK1(1), MAPK3(1), PDK2(1), PDPK1(2), PIK3CA(351), PIK3R1(15), PTEN(35), PTK2(7), SHC1(2), SOS1(5) 27074762 446 373 143 18 11 147 26 203 54 5 <1.00e-15 3.00e-15 3.54e-14 52 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 66 APAF1(11), BAD(1), BAK1(3), BAX(3), BCL2L1(1), BCL2L11(4), BID(3), BIRC2(3), BIRC3(4), BIRC5(1), CASP1(3), CASP10(2), CASP2(3), CASP3(1), CASP4(1), CASP6(2), CASP7(2), CASP8(10), CASP9(2), CHUK(7), DFFA(4), DFFB(2), FAS(1), FASLG(2), HELLS(3), IKBKB(5), IRF1(2), IRF2(1), IRF3(6), IRF4(2), IRF5(2), IRF6(3), JUN(3), LTA(2), MAP2K4(32), MAP3K1(80), MAPK10(4), MDM2(3), MYC(1), NFKB1(5), NFKBIA(3), NFKBIB(1), NFKBIE(2), PLEKHG5(2), PRF1(2), RELA(3), RIPK1(5), TNFRSF10B(1), TNFRSF1A(4), TNFRSF1B(2), TNFRSF21(2), TNFRSF25(2), TP53(299), TP73(2), TRAF1(2), TRAF2(1), TRAF3(3) 79298390 566 443 414 28 75 76 73 97 225 20 <1.00e-15 3.11e-15 3.54e-14 53 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 21 ATM(23), ATR(13), BRCA1(13), BRCA2(14), CHEK1(2), CHEK2(5), FANCA(8), FANCC(4), FANCD2(9), FANCE(2), FANCF(2), FANCG(4), HUS1(1), MRE11A(7), RAD1(1), RAD17(3), RAD50(6), RAD51(2), RAD9A(1), TP53(299) 63765290 419 360 280 28 57 72 48 88 154 0 3.99e-13 3.11e-15 3.54e-14 54 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 CREBBP(15), EP300(13), IL2RG(2), IL7(1), IL7R(4), JAK1(11), JAK3(8), LCK(2), NMI(2), PIK3CA(351), PIK3R1(15), PTK2B(6), STAT5A(6), STAT5B(5) 40188871 441 362 142 24 18 152 33 201 36 1 <1.00e-15 3.22e-15 3.54e-14 55 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT1(2), AKT2(4), AKT3(5), CDKN1A(1), ELK1(4), HRAS(2), MAP2K1(5), MAP2K2(2), NGFR(1), NTRK1(8), PIK3CA(351), PIK3CD(6), SHC1(2), SOS1(5) 22297075 398 344 100 18 14 146 23 193 22 0 <1.00e-15 3.22e-15 3.54e-14 56 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 17 DNAJA3(2), IFNG(2), IFNGR1(2), IKBKB(5), JAK2(7), LIN7A(1), NFKB1(5), NFKBIA(3), RB1(22), RELA(3), TNFRSF1A(4), TNFRSF1B(2), TP53(299), USH1C(5), WT1(3) 25151370 365 325 225 14 57 34 44 74 156 0 <1.00e-15 3.22e-15 3.54e-14 57 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 65 APAF1(11), ATM(23), ATR(13), BAI1(10), BAX(3), BBC3(1), BID(3), CASP3(1), CASP8(10), CASP9(2), CCNB1(3), CCNB3(14), CCND1(1), CCND2(2), CCND3(4), CCNE1(2), CCNE2(3), CCNG2(2), CDK2(2), CDK4(1), CDK6(2), CDKN1A(1), CDKN2A(1), CHEK1(2), CHEK2(5), DDB2(2), EI24(3), FAS(1), GTSE1(10), MDM2(3), MDM4(3), PERP(1), PPM1D(2), PTEN(35), RCHY1(2), RFWD2(2), RPRM(1), RRM2(1), RRM2B(1), SERPINE1(5), SESN2(2), SESN3(1), SFN(1), SIAH1(3), STEAP3(2), THBS1(8), TNFRSF10B(1), TP53(299), TP53I3(5), TP73(2), TSC2(6) 91368173 524 397 379 49 70 78 65 107 202 2 9.12e-13 3.33e-15 3.60e-14 58 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 ARNT(4), EIF2B1(2), EIF2B2(2), EIF2B3(2), EIF2B4(3), EIF2B5(4), EIF2S1(3), EIF2S2(3), EIF2S3(2), ELAVL1(4), FLT1(5), FLT4(3), HIF1A(4), HRAS(2), KDR(8), NOS3(3), PIK3CA(351), PIK3R1(15), PLCG1(8), PRKCA(4), PTK2(7), SHC1(2) 48376135 441 364 142 33 17 162 31 199 30 2 <1.00e-15 3.55e-15 3.69e-14 59 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 B2M(3), HLA-A(3), IL18(2), ITGB1(5), KLRC1(5), KLRC3(1), KLRD1(1), LAT(1), MAP2K1(5), MAPK3(1), PAK1(3), PIK3CA(351), PIK3R1(15), PTK2B(6), SYK(4), VAV1(6) 27029460 412 354 112 17 9 147 27 201 27 1 <1.00e-15 3.55e-15 3.69e-14 60 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 AKT1(2), CCND1(1), CCNE1(2), CDK2(2), CDK4(1), CDK6(2), CDKN1A(1), CDKN1B(10), E2F1(5), HRAS(2), MAPK1(1), MAPK3(1), NFKB1(5), NFKBIA(3), PAK1(3), PIK3CA(351), PIK3R1(15), RAF1(4), RB1(22), RELA(3), TFDP1(3) 28786247 439 368 137 18 18 145 24 197 52 3 <1.00e-15 3.66e-15 3.69e-14 61 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 AKT1(2), PIK3CA(351), PIK3R1(15), PLCB1(12), PLCG1(8), PRKCA(4), VAV1(6) 18627521 398 343 99 16 13 140 22 194 28 1 <1.00e-15 3.66e-15 3.69e-14 62 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 ARFIP2(3), CDK5(2), CDK5R1(1), CFL1(1), CHN1(4), LIMK1(7), MAP3K1(80), MYLK(11), NCF2(7), PAK1(3), PDGFRA(6), PIK3CA(351), PIK3R1(15), PLD1(7), PPP1R12B(4), RALBP1(3), RPS6KB1(4), TRIO(13), VAV1(6), WASF1(6) 50757842 534 401 226 41 15 164 43 210 83 19 <1.00e-15 3.77e-15 3.69e-14 63 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 ATF1(3), CASP2(3), CHUK(7), IKBKB(5), JUN(3), LTA(2), MAP2K3(3), MAP2K4(32), MAP2K6(1), MAP3K1(80), MAP4K2(2), MAPK14(1), MAPK8(2), NFKB1(5), NFKBIA(3), RELA(3), RIPK1(5), TANK(3), TNFRSF1A(4), TRAF2(1) 33727483 168 146 155 8 16 22 19 16 77 18 1.24e-05 3.77e-15 3.69e-14 64 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 42 AKT1(2), ASAH1(1), ATF1(3), BRAF(5), CREB1(1), CREB5(5), CREBBP(15), CRKL(1), DAG1(2), EGR1(3), EGR2(3), EGR3(4), ELK1(4), FRS2(1), GNAQ(1), JUN(3), MAP1B(8), MAP2K4(32), MAP2K7(1), MAPK1(1), MAPK10(4), MAPK3(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(8), MAPK9(1), NTRK1(8), OPN1LW(3), PIK3C2G(8), PIK3CA(351), PIK3CD(6), PIK3R1(15), PTPN11(1), RPS6KA3(8), SHC1(2), SRC(1), TERF2IP(3), TH(2) 71686075 523 398 218 41 41 165 38 211 67 1 <1.00e-15 3.89e-15 3.74e-14 65 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 AKT1(2), BCR(3), CRKL(1), HRAS(2), JAK2(7), JUN(3), MAP2K1(5), MAP2K4(32), MAP3K1(80), MAPK3(1), MAPK8(2), MYC(1), PIK3CA(351), PIK3R1(15), RAF1(4), SOS1(5), STAT1(4), STAT5A(6), STAT5B(5) 39045601 529 404 218 20 20 154 33 208 95 19 <1.00e-15 4.00e-15 3.79e-14 66 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 28 AKT1(2), CABIN1(8), CALM2(1), CAMK1(1), CAMK1G(5), HDAC5(6), IGF1R(7), INSR(11), MAP2K6(1), MAPK14(1), MAPK7(4), MEF2A(6), MEF2C(4), MEF2D(3), NFATC1(5), NFATC2(4), PIK3CA(351), PIK3R1(15), PPP3CA(5), PPP3CB(2), SYT1(1) 47844310 443 354 144 34 12 163 26 208 33 1 <1.00e-15 4.11e-15 3.83e-14 67 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 BTK(7), CALM2(1), ELK1(4), FCER1A(4), HRAS(2), JUN(3), LYN(6), MAP2K1(5), MAP2K4(32), MAP2K7(1), MAP3K1(80), MAPK1(1), MAPK3(1), MAPK8(2), NFATC1(5), NFATC2(4), NFATC3(7), NFATC4(6), PAK2(2), PIK3CA(351), PIK3R1(15), PLA2G4A(7), PLCG1(8), PPP3CA(5), PPP3CB(2), RAF1(4), SHC1(2), SOS1(5), SYK(4), SYT1(1), VAV1(6) 59937742 583 426 272 39 30 171 44 218 101 19 <1.00e-15 4.33e-15 3.92e-14 68 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 AKT1(2), BAD(1), CHRNB1(1), CHRNG(2), MUSK(8), PIK3CA(351), PIK3R1(15), PTK2(7), PTK2B(6), SRC(1), TERT(2) 23360276 396 340 97 17 11 143 23 193 25 1 <1.00e-15 4.33e-15 3.92e-14 69 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 24 ABL1(6), ATM(23), ATR(13), CCND1(1), CCNE1(2), CDC25A(1), CDK2(2), CDK4(1), CDK6(2), CDKN1A(1), CDKN1B(10), CDKN2A(1), E2F1(5), GSK3B(2), HDAC1(6), RB1(22), SKP2(2), TFDP1(3), TGFB1(2), TGFB2(1), TGFB3(1), TP53(299) 42382600 406 352 264 23 58 38 50 85 173 2 <1.00e-15 4.44e-15 3.96e-14 70 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 20 BAD(1), BAX(3), CASP8(10), MAP2K1(5), MAP2K4(32), MAP3K1(80), MAPK1(1), MAPK3(1), MAPK8(2), NFKB1(5), NSMAF(3), RAF1(4), RELA(3), RIPK1(5), SMPD1(2), TNFRSF1A(4), TRAF2(1) 28566121 162 138 149 7 14 21 14 17 78 18 9.14e-06 4.55e-15 4.01e-14 71 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 19 ABL1(6), ATM(23), BRCA1(13), CDKN1A(1), CHEK1(2), CHEK2(5), JUN(3), MAPK8(2), MDM2(3), MRE11A(7), NFKB1(5), NFKBIA(3), RAD50(6), RAD51(2), RBBP8(5), RELA(3), TP53(299), TP73(2) 41825646 390 347 251 18 58 55 46 81 150 0 <1.00e-15 4.66e-15 4.05e-14 72 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 12 AKT1(2), CAT(2), GHR(5), HRAS(2), IGF1R(7), PIK3CA(351), PIK3R1(15), SHC1(2), SOD1(1) 18605360 387 336 88 13 9 145 20 190 22 1 <1.00e-15 4.77e-15 4.08e-14 73 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 47 FN3K(3), IMPA2(4), INPP1(1), INPP4A(5), INPP4B(7), INPP5A(1), INPP5B(7), INPP5E(1), INPPL1(6), IPMK(1), ISYNA1(1), ITPK1(1), ITPKA(1), ITPKB(8), MINPP1(3), OCRL(8), PI4KA(9), PI4KB(5), PIK3C3(6), PIK3CA(351), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIP4K2A(2), PIP4K2C(6), PIP5K1A(6), PIP5K1B(2), PIP5K1C(5), PLCB1(12), PLCB2(7), PLCB3(2), PLCB4(15), PLCD1(3), PLCD3(2), PLCD4(6), PLCE1(15), PLCG1(8), PLCG2(8), PLCZ1(10), PTEN(35), SYNJ1(3), SYNJ2(3) 104605630 598 433 296 62 45 192 50 226 83 2 1.89e-15 5.00e-15 4.16e-14 74 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(12), DIAPH1(5), GSN(2), HRAS(2), ITGA1(6), ITGB1(5), MAP2K1(5), MAPK1(1), MAPK3(1), MYLK(11), PIK3CA(351), PIK3R1(15), PTK2(7), RAF1(4), ROCK1(8), SHC1(2), SRC(1), TLN1(15) 54575954 453 373 154 34 19 160 33 202 38 1 <1.00e-15 5.00e-15 4.16e-14 75 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 22 AKT1(2), EIF4A1(2), EIF4A2(10), EIF4G1(9), EIF4G2(2), EIF4G3(5), GHR(5), IRS1(4), MAPK1(1), MAPK14(1), MAPK3(1), MKNK1(2), PABPC1(2), PDK2(1), PDPK1(2), PIK3CA(351), PIK3R1(15), PRKCA(4), PTEN(35), RPS6KB1(4) 39671484 458 374 155 21 14 164 25 202 51 2 <1.00e-15 5.22e-15 4.17e-14 76 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 15 GATA3(100), IL4(1), MAF(1), MAP2K3(3), MAPK14(1), NFATC1(5), NFATC2(4), PRKACB(1), PRKACG(3), PRKAR1A(4), PRKAR2A(2), PRKAR2B(2) 14985720 127 118 83 14 4 11 9 8 94 1 0.681 5.22e-15 4.17e-14 77 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 74 AKT1(2), AKT2(4), AKT3(5), BTK(7), FCER1A(4), GAB2(5), HRAS(2), IL3(1), IL4(1), INPP5D(4), KRAS(6), LAT(1), LCP2(2), LYN(6), MAP2K1(5), MAP2K2(2), MAP2K3(3), MAP2K4(32), MAP2K6(1), MAP2K7(1), MAPK1(1), MAPK10(4), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8(2), MAPK9(1), MS4A2(3), NRAS(2), PDK1(2), PIK3CA(351), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R1(15), PIK3R2(4), PIK3R3(3), PIK3R5(5), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(2), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(1), PLCG1(8), PLCG2(8), PRKCA(4), PRKCD(5), PRKCE(8), RAF1(4), SOS1(5), SOS2(6), SYK(4), VAV1(6), VAV2(3), VAV3(7) 101532979 596 427 290 53 41 186 58 231 79 1 <1.00e-15 5.33e-15 4.17e-14 78 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 CSNK2A1(3), HRAS(2), JAK2(7), JUN(3), MAP2K1(5), MAPK3(1), MPL(2), PIK3CA(351), PIK3R1(15), PLCG1(8), PRKCA(4), RAF1(4), RASA1(2), SHC1(2), SOS1(5), STAT1(4), STAT3(5), STAT5A(6), STAT5B(5), THPO(3) 43015439 437 365 138 24 19 153 26 202 36 1 <1.00e-15 5.33e-15 4.17e-14 79 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 22 ATM(23), ATR(13), BRCA1(13), CCNB1(3), CDC25A(1), CDC25B(3), CDC25C(4), CDC34(1), CDKN1A(1), CHEK1(2), CHEK2(5), EP300(13), MDM2(3), MYT1(10), PRKDC(24), RPS6KA1(6), TP53(299), WEE1(4) 62620005 428 361 288 28 62 58 56 91 161 0 1.91e-14 5.44e-15 4.17e-14 80 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 81 AIFM1(3), AKT1(2), AKT2(4), AKT3(5), APAF1(11), ATM(23), BAD(1), BAX(3), BCL2L1(1), BID(3), BIRC2(3), BIRC3(4), CAPN1(8), CAPN2(8), CASP10(2), CASP3(1), CASP6(2), CASP7(2), CASP8(10), CASP9(2), CFLAR(1), CHUK(7), CSF2RB(4), DFFA(4), DFFB(2), FAS(1), FASLG(2), IKBKB(5), IL1A(1), IL1R1(1), IL1RAP(10), IL3(1), IL3RA(3), IRAK1(3), IRAK2(4), IRAK3(2), IRAK4(3), MYD88(1), NFKB1(5), NFKB2(5), NFKBIA(3), NTRK1(8), PIK3CA(351), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R1(15), PIK3R2(4), PIK3R3(3), PIK3R5(5), PPP3CA(5), PPP3CB(2), PPP3R1(1), PRKACA(3), PRKACB(1), PRKACG(3), PRKAR1A(4), PRKAR2A(2), PRKAR2B(2), RELA(3), RIPK1(5), TNFRSF10A(1), TNFRSF10B(1), TNFRSF10D(1), TNFRSF1A(4), TP53(299), TRAF2(1) 118964074 909 609 469 65 82 233 98 296 199 1 <1.00e-15 5.55e-15 4.17e-14 81 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 62 AKT1(2), AKT2(4), AKT3(5), BAD(1), BCL2L1(1), CDK2(2), CDKN1B(10), CDKN2A(1), CREB1(1), CREB5(5), EBP(1), ERBB4(13), F2RL2(2), GAB1(2), GSK3A(5), GSK3B(2), INPPL1(6), IRS1(4), IRS4(7), MET(10), MYC(1), NOLC1(2), PAK1(3), PAK2(2), PAK3(4), PAK4(3), PAK6(5), PAK7(4), PARD3(8), PARD6A(1), PDK1(2), PIK3CA(351), PIK3CD(6), PPP1R13B(4), PREX1(9), PTEN(35), PTK2(7), RPS6KA1(6), RPS6KA2(5), RPS6KA3(8), RPS6KB1(4), SFN(1), SHC1(2), SLC2A4(1), SOS1(5), SOS2(6), TSC1(5), TSC2(6), YWHAB(2), YWHAG(1), YWHAZ(3) 105489011 586 418 283 69 38 191 46 226 81 4 1.51e-12 5.55e-15 4.17e-14 82 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 AKT1(2), APC(23), AXIN1(5), CCND1(1), CD14(1), CTNNB1(2), DVL1(2), FZD1(3), GJA1(4), GNAI1(2), GSK3B(2), IRAK1(3), LBP(1), LY96(1), MYD88(1), NFKB1(5), PDPK1(2), PIK3CA(351), PIK3R1(15), PPP2CA(3), RELA(3), TIRAP(1), TLR4(15) 41906802 448 368 148 35 14 161 28 211 31 3 <1.00e-15 5.55e-15 4.17e-14 83 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 52 ACTA1(3), AGT(3), AKT1(2), CALM2(1), CALR(1), CAMK1(1), CAMK1G(5), CAMK4(5), CREBBP(15), CSNK1A1(3), EDN1(5), F2(2), GATA4(2), GSK3B(2), HAND2(3), HRAS(2), LIF(1), MAP2K1(5), MAPK1(1), MAPK14(1), MAPK3(1), MAPK8(2), MEF2C(4), MYH2(10), NFATC1(5), NFATC2(4), NFATC3(7), NFATC4(6), NKX2-5(1), NPPA(1), PIK3CA(351), PIK3R1(15), PPP3CA(5), PPP3CB(2), PRKACB(1), PRKACG(3), PRKAR1A(4), PRKAR2A(2), PRKAR2B(2), RAF1(4), RPS6KB1(4), SYT1(1) 70947847 498 383 199 57 25 175 43 215 38 2 3.16e-12 6.11e-15 4.53e-14 84 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 AKT1(2), APC(23), AR(6), ASAH1(1), BRAF(5), CCL13(2), CCL15(1), DAG1(2), EGFR(5), GNA11(3), GNAI1(2), GNAQ(1), ITPKA(1), ITPKB(8), ITPR1(15), ITPR2(18), ITPR3(14), KCNJ3(2), KCNJ5(1), KCNJ9(1), MAPK1(1), MAPK10(4), MAPK14(1), PHKA2(13), PIK3CA(351), PIK3CD(6), PIK3R1(15), PITX2(5), PTX3(1), RAF1(4), SRC(1) 76152445 515 398 214 50 28 175 33 230 47 2 2.00e-15 6.44e-15 4.72e-14 85 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 15 AKT1(2), EGFR(5), IGF1R(7), MYC(1), POLR2A(6), PPP2CA(3), PRKCA(4), RB1(22), TEP1(16), TERT(2), TNKS(5), TP53(299), XRCC5(3) 40079982 375 333 235 28 52 36 46 85 155 1 2.27e-13 6.77e-15 4.91e-14 86 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 57 ALG2(2), BAK1(3), BAX(3), BFAR(3), BTK(7), CAD(15), CASP10(2), CASP3(1), CASP8(10), CD7(1), CSNK1A1(3), DAXX(2), DEDD(1), DEDD2(1), DFFA(4), DIABLO(1), EGFR(5), EPHB2(5), FAF1(7), IL1A(1), MAP2K4(32), MAP2K7(1), MAP3K1(80), MAP3K5(12), MAPK1(1), MAPK10(4), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(8), MAPK9(1), MET(10), NFAT5(7), NFKB1(5), NFKB2(5), NFKBIA(3), NFKBIB(1), NFKBIE(2), NR0B2(2), PTPN13(16), RALBP1(3), RIPK1(5), ROCK1(8), SMPD1(2), TNFRSF6B(1), TP53(299), TPX2(2), TRAF2(1), TUFM(1) 97382261 594 448 441 52 83 78 75 109 230 19 3.11e-14 6.99e-15 5.01e-14 87 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 44 AKT1(2), AKT2(4), AKT3(5), BRAF(5), CAB39(1), DDIT4(1), EIF4B(2), FIGF(3), HIF1A(4), MAPK1(1), MAPK3(1), PDPK1(2), PGF(5), PIK3CA(351), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R1(15), PIK3R2(4), PIK3R3(3), PIK3R5(5), PRKAA1(3), PRKAA2(2), RHEB(1), RICTOR(7), RPS6(4), RPS6KA1(6), RPS6KA2(5), RPS6KA3(8), RPS6KA6(6), RPS6KB1(4), RPS6KB2(5), STK11(2), TSC1(5), TSC2(6), ULK1(4), ULK2(5), ULK3(4), VEGFA(1), VEGFC(2) 73821445 513 393 213 46 28 182 37 213 52 1 <1.00e-15 8.88e-15 6.22e-14 88 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 CSNK2A1(3), ELK1(4), HRAS(2), IGF1R(7), IRS1(4), JUN(3), MAP2K1(5), MAPK3(1), MAPK8(2), PIK3CA(351), PIK3R1(15), PTPN11(1), RAF1(4), RASA1(2), SHC1(2), SOS1(5), SRF(1) 34531036 412 348 113 23 12 150 23 196 30 1 <1.00e-15 8.88e-15 6.22e-14 89 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(4), CHUK(7), IFNG(2), IKBKB(5), IL4(1), JUN(3), MAP3K1(80), MAP3K5(12), MAP4K5(1), MAPK14(1), MAPK8(2), NFKB1(5), NFKBIA(3), RELA(3), TNFRSF9(2), TNFSF9(1), TRAF2(1) 28448903 133 112 124 10 15 17 12 12 59 18 0.0101 1.42e-14 9.84e-14 90 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 ARHGDIB(1), CASP10(2), CASP3(1), CASP6(2), CASP7(2), CASP8(10), CFLAR(1), DAXX(2), DFFA(4), DFFB(2), FAF1(7), JUN(3), LMNA(4), LMNB1(2), LMNB2(3), MAP2K4(32), MAP3K1(80), MAP3K7(3), MAPK8(2), PAK1(3), PAK2(2), PRKDC(24), PTPN13(16), RB1(22), RIPK2(2), SPTAN1(12) 61786868 244 189 230 20 20 35 27 32 112 18 0.000227 6.15e-14 4.21e-13 91 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 44 ACTR2(2), ACTR3(2), AKT1(2), AKT2(4), AKT3(5), ANGPTL2(1), ARHGAP1(2), ARHGAP4(4), ARHGEF11(6), BTK(7), CFL1(1), CFL2(1), GDI1(4), GDI2(2), INPPL1(6), ITPR1(15), ITPR2(18), ITPR3(14), LIMK1(7), MYLK(11), MYLK2(5), PAK1(3), PAK2(2), PAK3(4), PAK4(3), PAK6(5), PAK7(4), PDK1(2), PIK3CA(351), PIK3CD(6), PIK3CG(5), PIK3R1(15), PITX2(5), PPP1R13B(4), PTEN(35), RACGAP1(2), RHO(2), ROCK1(8), ROCK2(9), RPS4X(2), SAG(3), WASF1(6), WASL(4) 100306996 599 417 295 76 41 188 52 235 80 3 4.34e-11 9.04e-14 6.12e-13 92 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 13 CHUK(7), DUSP1(1), IKBKAP(12), IKBKB(5), MAP3K1(80), NFKB1(5), NFKBIA(3), RELA(3), TNFAIP3(3), TRAF3(3), TRAF6(4) 26683534 126 107 118 11 9 18 12 14 54 19 0.0245 5.70e-13 3.82e-12 93 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(6), CALM2(1), CRKL(1), GNAQ(1), HRAS(2), JUN(3), MAP2K1(5), MAP2K2(2), MAP2K3(3), MAP2K4(32), MAP3K1(80), MAPK1(1), MAPK14(1), MAPK3(1), MAPK8(2), PAK1(3), PLCG1(8), PRKCA(4), PTK2B(6), RAF1(4), SHC1(2), SOS1(5), SRC(1), SYT1(1) 40272197 175 152 163 17 15 23 17 21 80 19 0.00696 9.08e-13 6.01e-12 94 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(23), CDH1(109), CREBBP(15), EP300(13), MAP2K1(5), MAP3K7(3), MAPK3(1), SKIL(3), TGFB1(2), TGFB2(1), TGFB3(1), TGFBR1(4), TGFBR2(4) 37220426 184 151 165 18 16 26 15 17 109 1 0.00281 3.08e-12 2.02e-11 95 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 69 AKT1(2), AKT2(4), AKT3(5), BAD(1), CASP9(2), HRAS(2), KDR(8), KRAS(6), MAP2K1(5), MAP2K2(2), MAPK1(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPKAPK2(1), MAPKAPK3(2), NFAT5(7), NFATC1(5), NFATC2(4), NFATC3(7), NFATC4(6), NOS3(3), NRAS(2), PIK3CA(351), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R1(15), PIK3R2(4), PIK3R3(3), PIK3R5(5), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(2), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(1), PLCG1(8), PLCG2(8), PPP3CA(5), PPP3CB(2), PPP3R1(1), PRKCA(4), PRKCG(3), PTGS2(6), PTK2(7), RAF1(4), SH2D2A(3), SHC2(2), SPHK1(1), SPHK2(2), SRC(1), VEGFA(1) 99436239 552 404 250 71 36 186 59 222 48 1 1.54e-11 4.79e-11 3.10e-10 96 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 63 ATM(23), CCNB1(3), CCND1(1), CCND2(2), CCND3(4), CCNE1(2), CCNE2(3), CCNG2(2), CCNH(2), CDC25A(1), CDK2(2), CDK4(1), CDK7(3), CDKN1A(1), CDKN1B(10), CDKN2A(1), CREB3L1(3), CREB3L3(6), CREB3L4(2), E2F1(5), E2F2(1), E2F3(3), E2F4(2), E2F6(2), GBA2(4), MCM2(3), MCM3(3), MCM4(5), MCM5(3), MCM6(4), MCM7(7), MDM2(3), MNAT1(2), MYC(1), MYT1(10), NACA(8), POLA2(5), POLE(10), POLE2(2), PRIM1(1), RB1(22), RBL1(6), RPA1(1), RPA2(1), RPA3(2), TFDP1(3), TFDP2(4), TNXB(16), TP53(299), WEE1(4) 105118812 514 387 371 59 75 80 60 108 188 3 7.32e-10 3.01e-10 1.93e-09 97 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 18 CHUK(7), DUSP1(1), IKBKAP(12), IKBKB(5), LTA(2), MAP3K1(80), NFKB1(5), NFKBIA(3), RELA(3), RIPK1(5), TANK(3), TNFAIP3(3), TNFRSF1B(2), TRAF1(2), TRAF2(1), TRAF3(3) 32289242 137 113 129 13 12 21 17 13 55 19 0.0133 5.31e-10 3.37e-09 98 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 63 AKT1(2), AKT2(4), AKT3(5), BCL10(3), BLNK(1), BTK(7), CARD11(7), CD19(6), CD22(5), CD72(4), CD79B(2), CHUK(7), CR2(5), GSK3B(2), HRAS(2), IFITM1(1), IKBKB(5), INPP5D(4), JUN(3), KRAS(6), LILRB3(4), LYN(6), MALT1(3), NFAT5(7), NFATC1(5), NFATC2(4), NFATC3(7), NFATC4(6), NFKB1(5), NFKB2(5), NFKBIA(3), NFKBIB(1), NFKBIE(2), NRAS(2), PIK3CA(351), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R1(15), PIK3R2(4), PIK3R3(3), PIK3R5(5), PLCG2(8), PPP3CA(5), PPP3CB(2), PPP3R1(1), RASGRP3(2), SYK(4), VAV1(6), VAV2(3), VAV3(7) 104312855 576 414 273 77 42 191 56 229 57 1 6.78e-11 1.20e-09 7.56e-09 99 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 82 ABL1(6), ATM(23), BUB1(3), BUB1B(4), BUB3(3), CCNA2(4), CCNB1(3), CCNB3(14), CCND2(2), CCND3(4), CCNE1(2), CCNE2(3), CCNH(2), CDAN1(2), CDC14A(3), CDC14B(1), CDC20(1), CDC25A(1), CDC25B(3), CDC25C(4), CDC6(4), CDC7(2), CDH1(109), CDK2(2), CDK4(1), CDKN1A(1), CDKN2A(1), CHEK1(2), CHEK2(5), DTX4(2), E2F1(5), E2F2(1), E2F3(3), E2F4(2), E2F6(2), EP300(13), ESPL1(13), GSK3B(2), HDAC1(6), HDAC2(2), HDAC3(1), HDAC4(5), HDAC5(6), HDAC6(16), HDAC8(3), MAD1L1(4), MAD2L1(4), MAD2L2(2), MCM2(3), MCM3(3), MCM4(5), MCM5(3), MCM6(4), MCM7(7), MDM2(3), MPEG1(4), MPL(2), PLK1(2), PRKDC(24), PTPRA(6), PTTG1(1), RB1(22), RBL1(6), SKP2(2), SMAD4(7), TBC1D8(7), TFDP1(3), TGFB1(2), TP53(299), WEE1(4) 160503187 726 504 565 86 87 116 87 126 309 1 1.27e-10 2.55e-09 1.58e-08 100 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 32 CD14(1), CHUK(7), ELK1(4), IKBKB(5), IRAK1(3), JUN(3), LY96(1), MAP2K3(3), MAP2K4(32), MAP2K6(1), MAP3K1(80), MAP3K7(3), MAPK14(1), MAPK8(2), MYD88(1), NFKB1(5), NFKBIA(3), PPARA(4), RELA(3), TIRAP(1), TLR10(3), TLR2(3), TLR3(7), TLR4(15), TLR7(9), TLR9(2), TRAF6(4) 51910836 206 168 193 25 19 34 26 24 85 18 0.0106 3.13e-09 1.93e-08 101 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(5), EGFR(5), MAP2K1(5), MAP3K1(80), MAPK14(1), NCOR2(8), RARA(1), RXRA(2), THRA(3), THRB(2) 24057423 112 99 103 14 5 8 12 14 55 18 0.343 9.77e-08 5.96e-07 102 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGT(3), AGTR1(4), ATF2(4), CALM2(1), EGFR(5), ELK1(4), GNAQ(1), HRAS(2), JUN(3), MAP2K1(5), MAP2K2(2), MAP2K4(32), MAP3K1(80), MAPK1(1), MAPK3(1), MAPK8(2), MEF2A(6), MEF2C(4), MEF2D(3), PAK1(3), PRKCA(4), PTK2(7), PTK2B(6), RAF1(4), SHC1(2), SOS1(5), SRC(1), SYT1(1) 49135724 196 161 183 23 18 31 21 28 80 18 0.00940 1.52e-07 9.19e-07 103 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 CHUK(7), IKBKB(5), IL1A(1), IL1R1(1), IRAK1(3), MAP3K1(80), MAP3K7(3), MYD88(1), NFKB1(5), NFKBIA(3), RELA(3), RIPK1(5), TLR4(15), TNFAIP3(3), TNFRSF1A(4), TNFRSF1B(2), TRAF6(4) 33770138 145 116 135 17 12 23 16 18 58 18 0.0493 1.97e-06 1.18e-05 104 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 85 ABL1(6), ABL2(6), AKT1(2), AKT2(4), AKT3(5), ARAF(5), AREG(1), BAD(1), BRAF(5), CAMK2A(3), CAMK2B(2), CAMK2D(4), CAMK2G(2), CBL(4), CBLB(14), CBLC(7), CDKN1A(1), CDKN1B(10), CRK(1), CRKL(1), EGF(5), EGFR(5), ELK1(4), ERBB2(21), ERBB3(17), ERBB4(13), GAB1(2), GSK3B(2), HRAS(2), JUN(3), KRAS(6), MAP2K1(5), MAP2K2(2), MAP2K4(32), MAP2K7(1), MAPK1(1), MAPK10(4), MAPK3(1), MAPK8(2), MAPK9(1), MYC(1), NCK1(2), NCK2(1), NRAS(2), NRG1(2), NRG2(4), NRG3(6), NRG4(1), PAK1(3), PAK2(2), PAK3(4), PAK4(3), PAK6(5), PAK7(4), PIK3CA(351), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R1(15), PIK3R2(4), PIK3R3(3), PIK3R5(5), PLCG1(8), PLCG2(8), PRKCA(4), PRKCG(3), PTK2(7), RAF1(4), RPS6KB1(4), RPS6KB2(5), SHC1(2), SHC2(2), SHC3(1), SHC4(5), SOS1(5), SOS2(6), SRC(1), STAT5A(6), STAT5B(5), TGFA(1) 144228926 727 458 411 96 60 224 75 265 100 3 6.68e-13 2.32e-05 0.000137 105 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 38 ATF2(4), CREB1(1), DAXX(2), ELK1(4), HMGN1(1), HRAS(2), MAP2K4(32), MAP2K6(1), MAP3K1(80), MAP3K5(12), MAP3K7(3), MAP3K9(5), MAPK14(1), MAPKAPK2(1), MAX(2), MEF2A(6), MEF2C(4), MEF2D(3), MKNK1(2), MYC(1), PLA2G4A(7), RIPK1(5), RPS6KA5(4), SHC1(2), STAT1(4), TGFB1(2), TGFB2(1), TGFB3(1), TGFBR1(4), TRAF2(1) 52784942 198 155 185 24 20 33 19 31 77 18 0.0157 3.62e-05 0.000213 106 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CCNE1(2), CDK2(2), CDKN1B(10), CKS1B(1), CUL1(2), E2F1(5), NEDD8(1), RB1(22), SKP2(2), TFDP1(3) 12487805 50 46 47 7 5 7 3 4 29 2 0.217 0.00134 0.00779 107 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CCNE1(2), CDC34(1), CDK2(2), CUL1(2), E2F1(5), FBXW7(15), RB1(22), TFDP1(3) 12234801 52 48 48 7 10 8 4 6 24 0 0.116 0.00156 0.00901 108 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 ATF2(4), BCR(3), BLNK(1), ELK1(4), HRAS(2), JUN(3), LYN(6), MAP2K1(5), MAP3K1(80), MAPK1(1), MAPK3(1), MAPK8IP3(8), PAPPA(13), RPS6KA1(6), RPS6KA3(8), SHC1(2), SOS1(5), SYK(4), VAV1(6), VAV2(3), VAV3(7) 44618676 172 136 163 24 21 24 21 26 62 18 0.0459 0.00232 0.0132 109 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 78 ABL1(6), ACTN1(5), ACTR2(2), ACTR3(2), AKT1(2), AKT2(4), AKT3(5), ANGPTL2(1), ARHGEF6(6), ARHGEF7(8), BCAR1(6), BRAF(5), CAV1(4), CDKN2A(1), CRK(1), CSE1L(6), DOCK1(8), EPHB2(5), GRB7(4), ILK(3), ITGA1(6), ITGA10(10), ITGA11(7), ITGA2(4), ITGA4(6), ITGA5(4), ITGA6(4), ITGA7(5), ITGA8(10), ITGA9(7), ITGB3BP(3), MAP2K4(32), MAP2K7(1), MAPK1(1), MAPK10(4), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(8), MAPK9(1), MRAS(2), MYLK(11), MYLK2(5), P4HB(2), PAK1(3), PAK2(2), PAK3(4), PAK4(3), PAK6(5), PAK7(4), PIK3CA(351), PIK3CB(8), PKLR(5), PLCG1(8), PLCG2(8), PTEN(35), PTK2(7), RAF1(4), RALA(1), RHO(2), ROCK1(8), ROCK2(9), SHC1(2), SOS1(5), SOS2(6), SRC(1), TERF2IP(3), TLN1(15), TLN2(14), WAS(7), ZYX(1) 173915506 743 471 438 98 70 222 68 267 113 3 1.50e-13 0.00358 0.0203 110 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(7), IFNA1(1), IKBKB(5), IL1A(1), IL1R1(1), IL1RAP(10), IL1RN(2), IL6(1), IRAK1(3), IRAK2(4), IRAK3(2), JUN(3), MAP2K3(3), MAP2K6(1), MAP3K1(80), MAP3K7(3), MAPK14(1), MAPK8(2), MYD88(1), NFKB1(5), NFKBIA(3), RELA(3), TGFB1(2), TGFB2(1), TGFB3(1), TRAF6(4) 42383597 150 128 142 21 14 22 19 18 59 18 0.158 0.00850 0.0476 111 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYB(1), NFYC(3), RB1(22), SP1(6), SP3(7) 9748288 39 36 37 7 1 5 3 7 23 0 0.423 0.0107 0.0596 112 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3E(3), CD3G(3) 1708219 6 6 6 0 0 2 1 2 1 0 0.271 0.0958 0.527 113 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNE1(2), CDC34(1), CDK2(2), CUL1(2), E2F1(5), RB1(22), SKP2(2), TFDP1(3) 12536756 39 35 37 6 5 6 3 3 22 0 0.253 0.164 0.896 114 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 151 AKT1(2), AKT2(4), AKT3(5), BCL2L1(1), CBL(4), CBLB(14), CBLC(7), CCND1(1), CCND2(2), CCND3(4), CISH(2), CLCF1(1), CNTFR(2), CREBBP(15), CRLF2(1), CSF2RA(2), CSF2RB(4), CSF3(2), CSF3R(6), EP300(13), EPO(1), EPOR(4), GH2(2), GHR(5), IFNA1(1), IFNA10(3), IFNA13(3), IFNA14(3), IFNA16(2), IFNA17(3), IFNA2(3), IFNA21(4), IFNA4(2), IFNA6(1), IFNA7(2), IFNA8(2), IFNAR1(2), IFNAR2(1), IFNG(2), IFNGR1(2), IFNK(2), IL10RA(1), IL10RB(3), IL11(1), IL11RA(5), IL12B(2), IL12RB1(7), IL12RB2(4), IL13RA1(1), IL13RA2(5), IL15(3), IL19(1), IL20(1), IL20RA(1), IL21(2), IL21R(2), IL22(2), IL22RA1(4), IL22RA2(3), IL23A(2), IL23R(4), IL24(3), IL2RA(2), IL2RB(3), IL2RG(2), IL3(1), IL3RA(3), IL4(1), IL4R(6), IL5RA(4), IL6(1), IL6R(4), IL6ST(9), IL7(1), IL7R(4), IL9R(2), IRF9(4), JAK1(11), JAK2(7), JAK3(8), LEP(1), LEPR(7), LIF(1), LIFR(9), MPL(2), MYC(1), OSM(1), OSMR(5), PIAS1(3), PIAS2(7), PIAS3(2), PIAS4(3), PIK3CA(351), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R1(15), PIK3R2(4), PIK3R3(3), PIK3R5(5), PRLR(4), PTPN11(1), SOCS2(1), SOCS4(2), SOCS5(1), SOS1(5), SOS2(6), SPRED1(7), SPRED2(1), SPRY1(7), SPRY2(2), SPRY3(6), STAM(3), STAM2(4), STAT1(4), STAT2(5), STAT3(5), STAT4(8), STAT5A(6), STAT5B(5), STAT6(7), TPO(7), TSLP(1), TYK2(7) 206983430 816 493 513 111 63 248 107 284 111 3 3.30e-14 0.167 0.902 115 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 CASP3(1), CASP8(10), CFL1(1), CFLAR(1) 5476292 13 13 13 2 1 1 2 4 5 0 0.311 0.259 1.000 116 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(5), SUCLA2(1) 3044170 6 6 6 1 2 1 0 2 1 0 0.484 0.367 1.000 117 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 CMBL(1) 739599 1 1 1 0 0 0 0 1 0 0 0.800 0.391 1.000 118 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CCR5(1), CD28(2), CD3E(3), CD3G(3), CD4(4) 4752811 13 12 13 3 1 3 2 3 4 0 0.519 0.456 1.000 119 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CALM2(1), CHUK(7), EGR2(3), EGR3(4), GNAQ(1), MAP3K1(80), MYC(1), NFATC1(5), NFATC2(4), NFKB1(5), NFKBIA(3), PLCG1(8), PPP3CA(5), PPP3CB(2), PRKACB(1), PRKACG(3), PRKAR1A(4), PRKAR2A(2), PRKAR2B(2), RELA(3), SYT1(1), VIP(1), VIPR2(3) 38359708 149 125 141 27 15 25 15 17 59 18 0.440 0.460 1.000 120 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA2(4), CCND1(1), CCNE1(2), CCNE2(3), CDK2(2), CDK4(1), CDKN1B(10), CDKN2A(1), E2F1(5), E2F2(1), E2F4(2), PRB1(3) 12122159 35 33 33 7 5 6 2 3 17 2 0.453 0.462 1.000 121 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(1), DAG1(2), GNAQ(1), ITPKA(1), ITPKB(8) 7947000 13 13 13 1 2 4 1 3 3 0 0.138 0.474 1.000 122 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 24 ATM(23), BMPR1B(6), CCND2(2), CDK4(1), CDKN1B(10), DAZL(1), DMC1(2), EGR1(3), ESR2(4), FSHR(9), GJA4(1), INHA(5), LHCGR(10), MLH1(7), MSH5(6), NCOR1(41), NR5A1(1), NRIP1(10), PGR(6), PRLR(4), PTGER2(3), SMPD1(2), ZP2(4) 48318319 161 118 156 23 19 35 22 24 59 2 0.0107 0.476 1.000 123 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 9 B3GALT1(3), B3GALT2(2), B3GALT5(2), B3GNT5(4), FUT1(1), FUT3(3), ST3GAL3(4), ST3GAL4(2) 9411230 21 18 21 2 5 6 7 3 0 0 0.0487 0.492 1.000 124 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(6), CYP2C9(3) 2944424 9 9 9 2 1 4 2 2 0 0 0.487 0.511 1.000 125 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 19 APAF1(11), BAK1(3), BAX(3), BCL2L1(1), BID(3), BIK(1), BIRC2(3), BIRC3(4), CASP3(1), CASP6(2), CASP7(2), CASP8(10), CASP9(2), DFFA(4), DFFB(2), DIABLO(1) 19352472 53 40 52 4 4 21 8 6 14 0 0.00721 0.522 1.000 126 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNG(2), IFNGR1(2), JAK1(11), JAK2(7), STAT1(4) 12001014 26 24 26 2 2 5 6 5 8 0 0.0771 0.536 1.000 127 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(2), GSTZ1(1), HGD(4) 3252093 7 7 7 2 1 0 2 3 1 0 0.708 0.557 1.000 128 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 82 ACVR1B(8), ACVRL1(1), AKT1(2), AURKB(2), BMPR1A(1), BMPR2(8), BUB1(3), CDKL1(4), CDKL2(1), CDS1(3), CDS2(3), CLK1(2), CLK2(6), CLK4(3), COL4A3BP(4), CSNK2A1(3), CSNK2A2(1), DGKA(2), DGKB(5), DGKD(8), DGKE(4), DGKG(8), DGKH(4), DGKQ(1), DGKZ(1), INPP1(1), INPP4A(5), INPP4B(7), INPP5A(1), INPPL1(6), ITPKA(1), ITPKB(8), MAP3K10(3), MOS(3), NEK1(6), NEK3(3), OCRL(8), PAK4(3), PIK3C2A(5), PIK3C2B(12), PIK3C2G(8), PIK3CA(351), PIK3CB(8), PIK3CG(5), PIM2(4), PLCB1(12), PLCB2(7), PLCB3(2), PLCB4(15), PLCD1(3), PLCG1(8), PLCG2(8), PLK3(1), PRKACA(3), PRKACB(1), PRKACG(3), PRKAR1A(4), PRKAR2A(2), PRKAR2B(2), PRKCA(4), PRKCD(5), PRKCE(8), PRKCG(3), PRKCH(3), PRKCQ(8), PRKCZ(2), PRKD1(5), PRKG1(4), RAF1(4), RPS6KA1(6), RPS6KA2(5), RPS6KA3(8), RPS6KA4(2), RPS6KB1(4), STK11(2), TGFBR1(4), VRK1(2) 162679927 686 455 384 99 63 215 58 251 96 3 4.05e-10 0.574 1.000 129 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 11 APAF1(11), BAD(1), BAK1(3), BAX(3), BCL10(3), BCL2L1(1), BCL2L11(4), BID(3), CASP9(2), CES1(4) 10869574 35 28 35 5 6 16 4 4 5 0 0.0991 0.578 1.000 130 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 CDK5(2), CDK5R1(1), DAB1(5), LRP8(6), RELN(26), VLDLR(9) 20137509 49 38 47 4 8 12 12 7 9 1 0.00616 0.578 1.000 131 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNB1(3), CCNH(2), CDC25A(1), CDC25B(3), CDC25C(4), CDK7(3), MNAT1(2), SHH(1), XPO1(15) 12412367 34 28 33 4 8 16 3 2 5 0 0.0741 0.579 1.000 132 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(4), HLCS(3), SPCS3(1) 4480610 8 8 8 0 1 5 2 0 0 0 0.0842 0.609 1.000 133 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(3), GOT1(2), GOT2(1), TAT(3), TYR(5) 6781413 14 13 14 3 3 2 5 2 2 0 0.505 0.624 1.000 134 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(1) 1048037 1 1 1 1 0 0 0 0 1 0 0.943 0.641 1.000 135 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(2), GOT2(1), TAT(3) 3784360 6 5 6 1 1 1 1 1 2 0 0.642 0.645 1.000 136 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 3 CD28(2), CD4(4), HLA-DRB1(10) 2584921 16 15 16 8 1 2 5 4 4 0 0.911 0.656 1.000 137 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(5), CREM(2), FHL5(3), FSHR(9), GNAS(11), XPO1(15) 12910772 45 36 44 8 11 9 9 10 6 0 0.246 0.684 1.000 138 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA1(2), NDUFA10(1), NDUFA4(1), NDUFB5(3), NDUFB6(2), NDUFS1(1), NDUFS2(7), NDUFV1(5), NDUFV2(1) 10303281 23 21 23 3 5 4 4 6 4 0 0.224 0.694 1.000 139 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(5), ESR2(4), ITPKA(1), PDE1A(5), PDE1B(5), PLCB1(12), PLCB2(7), TRH(1), VIP(1) 15499132 41 32 41 5 6 11 6 9 9 0 0.0701 0.722 1.000 140 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(1), TPI1(2) 2287685 3 3 3 1 0 1 1 0 1 0 0.761 0.749 1.000 141 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 9 BAG4(1), BIRC3(4), CASP8(10), RIPK1(5), TNFRSF1A(4), TNFRSF1B(2), TRAF2(1) 10577547 27 25 26 5 5 8 4 3 7 0 0.224 0.764 1.000 142 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(4), GNAQ(1), GNB1(2), HTR2C(5), PLCB1(12), TUB(4) 10158106 28 23 28 5 8 5 3 6 6 0 0.211 0.781 1.000 143 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(5), GNAS(11), GNB1(2), PRKACA(3), PRKAR1A(4) 8511207 25 23 25 5 7 4 4 5 5 0 0.412 0.785 1.000 144 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 93 AKT1(2), AKT2(4), AKT3(5), BCL10(3), CARD11(7), CBL(4), CBLB(14), CBLC(7), CD28(2), CD3E(3), CD3G(3), CD4(4), CD40LG(1), CD8A(3), CD8B(3), CDK4(1), CHUK(7), CTLA4(1), GRAP2(2), HRAS(2), ICOS(3), IFNG(2), IKBKB(5), IL4(1), ITK(7), JUN(3), KRAS(6), LAT(1), LCK(2), LCP2(2), MALT1(3), MAP3K8(4), NCK1(2), NCK2(1), NFAT5(7), NFATC1(5), NFATC2(4), NFATC3(7), NFATC4(6), NFKB1(5), NFKB2(5), NFKBIA(3), NFKBIB(1), NFKBIE(2), NRAS(2), PAK1(3), PAK2(2), PAK3(4), PAK4(3), PAK6(5), PAK7(4), PDCD1(2), PDK1(2), PIK3CA(351), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R1(15), PIK3R2(4), PIK3R3(3), PIK3R5(5), PLCG1(8), PPP3CA(5), PPP3CB(2), PPP3R1(1), PRKCQ(8), PTPRC(8), RHOA(6), SOS1(5), SOS2(6), TEC(6), VAV1(6), VAV2(3), VAV3(7), ZAP70(3) 141875482 663 446 360 100 49 216 74 243 79 2 7.35e-09 0.800 1.000 145 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 51 ACTG1(8), APAF1(11), ARHGDIB(1), BAG4(1), BID(3), BIRC2(3), BIRC3(4), CASP2(3), CASP3(1), CASP6(2), CASP7(2), CASP8(10), CASP9(2), CFLAR(1), CHUK(7), DAXX(2), DFFA(4), DFFB(2), GSN(2), LMNA(4), LMNB1(2), LMNB2(3), MAP2K7(1), MAP3K1(80), MAP3K5(12), MAPK8(2), MDM2(3), NFKB1(5), NFKBIA(3), NUMA1(6), PAK2(2), PRKCD(5), PRKDC(24), PSEN1(2), PSEN2(4), PTK2(7), RASA1(2), RB1(22), RELA(3), RIPK1(5), SPTAN1(12), TNFRSF1A(4), TNFRSF1B(2), TRAF1(2), TRAF2(1) 99244965 287 204 275 32 39 53 36 39 102 18 0.000167 0.803 1.000 146 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(4), CHRNA1(4), SNAP25(3), STX1A(2), VAMP2(1) 4605994 14 12 14 4 3 5 2 3 1 0 0.541 0.815 1.000 147 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(3), PGLYRP2(1) 2465890 4 4 4 2 0 0 0 2 2 0 0.916 0.825 1.000 148 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(1), ALDOA(5), ALDOB(3), ALDOC(2), TPI1(2) 5549039 13 13 13 3 2 7 1 1 2 0 0.375 0.830 1.000 149 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 7 CCL11(1), CCR3(2), HLA-DRB1(10), IL3(1) 3491516 14 13 14 6 1 2 4 4 3 0 0.863 0.831 1.000 150 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(1), B4GALT1(3), B4GALT3(2), B4GALT5(4), FUT8(3), ST3GAL1(2), ST3GAL2(2), ST3GAL3(4), ST3GAL4(2) 10975810 23 20 23 4 3 9 5 3 3 0 0.221 0.837 1.000 151 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDFT1(4), FDPS(5), IDI1(5), SQLE(2) 4788842 16 15 15 4 3 6 3 1 3 0 0.627 0.845 1.000 152 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(4), IARS(8), LARS(5), LARS2(3), PDHA1(3), PDHA2(4), PDHB(1) 14627323 28 25 28 4 3 10 6 5 4 0 0.133 0.867 1.000 153 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(3), SLPI(1) 2295771 4 4 4 2 0 0 3 1 0 0 0.867 0.867 1.000 154 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(2), ST3GAL1(2), ST3GAL2(2), ST3GAL4(2), ST3GAL5(2), ST6GALNAC2(2), ST6GALNAC4(1), ST8SIA1(1) 7671895 14 14 14 3 2 3 4 3 2 0 0.447 0.871 1.000 155 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(3), LPL(1), NR3C1(3), PPARG(5), RXRA(2) 7587876 14 14 13 3 3 2 4 2 3 0 0.452 0.873 1.000 156 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 BPNT1(2), PAPSS1(2), PAPSS2(2), SULT1A2(2), SULT1E1(3), SUOX(4) 8888263 15 13 15 3 3 3 4 3 2 0 0.513 0.883 1.000 157 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(3), AKR1D1(1), CYP11A1(1), CYP11B1(5), CYP11B2(4), CYP17A1(3), CYP21A2(3), HSD11B1(3), HSD11B2(2), HSD3B1(3), HSD3B2(4) 12847026 32 30 31 6 4 12 8 5 3 0 0.116 0.889 1.000 158 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(3), AKR1D1(1), CYP11A1(1), CYP11B1(5), CYP11B2(4), CYP17A1(3), CYP21A2(3), HSD11B1(3), HSD11B2(2), HSD3B1(3), HSD3B2(4) 12847026 32 30 31 6 4 12 8 5 3 0 0.116 0.889 1.000 159 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(6), GAD1(3), PNMT(1), TH(2), TPH1(2) 7970227 14 13 14 3 5 3 2 1 3 0 0.398 0.891 1.000 160 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(23), CDC25A(1), CDC25B(3), CDC25C(4), CHEK1(2), MYT1(10), WEE1(4) 20101230 47 42 46 7 5 18 4 9 11 0 0.210 0.898 1.000 161 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP2(1), ACP5(3), ACPP(6), ACPT(1), ENPP1(7), ENPP3(5), FLAD1(7), RFK(1), TYR(5) 14087489 36 32 35 6 7 8 10 6 5 0 0.124 0.899 1.000 162 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(3), ARG1(3), GLS(4), GLUD1(2), OAT(2), PRODH(2) 7882934 16 12 16 2 1 5 2 3 5 0 0.318 0.904 1.000 163 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 7 CD28(2), CD4(4), HLA-DRB1(10), IL4(1) 4898108 17 16 17 9 1 2 5 4 5 0 0.958 0.905 1.000 164 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDHB(1), BCKDK(5), CBS(1), CTH(3), MUT(3) 6903634 13 13 13 3 2 3 2 2 4 0 0.524 0.909 1.000 165 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(2) 8282627 9 9 9 2 2 2 5 0 0 0 0.509 0.914 1.000 166 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(11), CD44(3), CSF1(5), FCGR3A(3), IL6R(4), SELL(6), SPN(2), TGFB1(2), TGFB2(1), TNFRSF1A(4), TNFRSF1B(2), TNFRSF8(4), TNFSF8(2) 18703012 49 37 47 8 7 12 5 12 13 0 0.0752 0.916 1.000 167 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ3(2), COQ5(1), COQ6(4) 6029332 7 7 7 0 1 3 2 1 0 0 0.169 0.919 1.000 168 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(3), HK1(3), HK2(5), HK3(5), PGM1(5), PGM3(2), TGDS(3) 14562762 26 23 26 4 4 3 5 9 5 0 0.139 0.920 1.000 169 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(3), CHAT(2), CHKA(1), PCYT1A(2), PDHA1(3), PDHA2(4), PEMT(1), SLC18A3(3) 9265911 19 17 19 4 5 4 4 4 2 0 0.304 0.920 1.000 170 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CCR5(1), CD3E(3), CD3G(3), CXCR3(6), ETV5(8), IFNG(2), IL12B(2), IL12RB1(7), IL12RB2(4), IL18(2), IL18R1(4), JAK2(7), JUN(3), MAP2K6(1), MAPK14(1), MAPK8(2), STAT4(8), TYK2(7) 27038005 71 59 69 11 11 17 11 17 15 0 0.0648 0.923 1.000 171 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(10), BAIAP2(2), CASP1(3), CASP3(1), CASP7(2), CASP8(10), GAPDH(1), INSR(11), ITCH(4), MAGI1(15), MAGI2(9), RERE(12), WWP1(6), WWP2(12) 33403861 98 67 95 13 13 35 13 24 12 1 0.00407 0.926 1.000 172 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(3), F13B(5), HSD17B1(1), HSD17B2(4), HSD17B3(2), HSD17B4(8), HSD3B1(3), HSD3B2(4) 11647324 30 30 29 7 2 8 10 6 4 0 0.425 0.926 1.000 173 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(4), FARSA(3), FARSB(5), GOT1(2), GOT2(1), PAH(3), TAT(3), YARS(4), YARS2(1) 12545778 26 20 26 4 3 11 3 5 4 0 0.211 0.941 1.000 174 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(3), ASL(4), CPS1(12), GLS(4), GLUD1(2), GOT1(2) 11122150 27 22 27 5 0 5 11 6 5 0 0.355 0.944 1.000 175 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), IL13RA2(5), IL4R(6), JAK1(11), JAK2(7), TYK2(7) 14840467 37 33 35 7 3 4 12 8 10 0 0.369 0.945 1.000 176 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), IL13RA2(5), IL4R(6), JAK1(11), JAK2(7), TYK2(7) 14840467 37 33 35 7 3 4 12 8 10 0 0.369 0.945 1.000 177 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(1), CDC25B(3), CDK7(3), CDKN1A(1), CHEK1(2), NEK1(6), WEE1(4) 11040121 20 18 20 3 3 9 0 1 7 0 0.515 0.946 1.000 178 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CCL2(1), CSF1(5), MST1R(8) 8256780 14 11 14 2 3 8 1 1 1 0 0.202 0.946 1.000 179 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(11), ARHGAP5(12), ARHGDIB(1), CASP1(3), CASP10(2), CASP3(1), CASP8(10), CASP9(2), JUN(3), PRF1(2) 18466137 47 39 47 8 5 10 7 7 18 0 0.241 0.951 1.000 180 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 73 CALM2(1), CALML6(1), CDS1(3), CDS2(3), DGKA(2), DGKB(5), DGKD(8), DGKE(4), DGKG(8), DGKH(4), DGKI(7), DGKQ(1), DGKZ(1), FN3K(3), IMPA2(4), INPP1(1), INPP4A(5), INPP4B(7), INPP5A(1), INPP5B(7), INPP5D(4), INPP5E(1), INPPL1(6), ITPK1(1), ITPKA(1), ITPKB(8), ITPR1(15), ITPR2(18), ITPR3(14), OCRL(8), PI4KA(9), PI4KB(5), PIK3C2A(5), PIK3C2B(12), PIK3C2G(8), PIK3C3(6), PIK3CA(351), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R1(15), PIK3R2(4), PIK3R3(3), PIK3R5(5), PIP4K2A(2), PIP4K2C(6), PIP5K1A(6), PIP5K1B(2), PIP5K1C(5), PLCB1(12), PLCB2(7), PLCB3(2), PLCB4(15), PLCD1(3), PLCD3(2), PLCD4(6), PLCE1(15), PLCG1(8), PLCG2(8), PLCZ1(10), PRKCA(4), PRKCG(3), PTEN(35), SYNJ1(3), SYNJ2(3) 179350680 751 490 445 115 67 229 68 268 116 3 2.60e-09 0.952 1.000 181 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 16 ALOX12(7), ALOX15(4), ALOX15B(5), ALOX5(3), ALOX5AP(1), DPEP1(2), GGT1(4), LTA4H(2), PLA2G2A(1), PLA2G6(1), PTGDS(2), PTGIS(4), PTGS1(5), PTGS2(6), TBXAS1(3) 21320989 50 39 50 7 10 11 12 9 8 0 0.0175 0.953 1.000 182 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 21 CCNB1(3), CCND1(1), CCND2(2), CCND3(4), CCNE1(2), CCNH(2), CDC25A(1), CDK2(2), CDK4(1), CDK6(2), CDK7(3), CDKN1A(1), CDKN1B(10), CDKN2A(1), E2F1(5), RB1(22), RBL1(6), TFDP1(3) 22209381 71 65 68 13 7 8 9 7 37 3 0.368 0.954 1.000 183 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(3), KHK(4), LCT(17), MPI(2), PGM1(5), PYGL(3), PYGM(5), TPI1(2), TREH(2) 19348985 43 39 43 8 8 7 8 9 11 0 0.137 0.961 1.000 184 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 AOC2(6), AOC3(3), CES1(4), ESD(2) 8189386 15 11 15 4 1 3 6 3 2 0 0.505 0.962 1.000 185 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(11), JAK2(7), JAK3(8), MAPK1(1), MAPK3(1), STAT3(5), TYK2(7) 16432080 40 34 38 7 8 5 9 7 11 0 0.215 0.964 1.000 186 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 GNAQ(1), NFKB1(5), NFKBIA(3), PLCB1(12), PRKCA(4), RELA(3) 11785977 28 23 28 5 6 4 4 6 8 0 0.291 0.966 1.000 187 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(4), CD34(2), CD3E(3), CD3G(3), CD4(4), CD58(2), CD8A(3), CSF3(2), IL3(1), IL6(1), KITLG(3) 9045178 28 26 28 7 2 10 6 4 6 0 0.401 0.971 1.000 188 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALT(1), TGDS(3), UGDH(1), UGP2(4), UXS1(3) 7322449 12 11 12 3 2 7 1 1 1 0 0.578 0.971 1.000 189 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO2(1), ENO3(2), FARS2(4), GOT1(2), GOT2(1), PAH(3), TAT(3), YARS(4) 11963381 20 15 20 3 3 5 5 4 3 0 0.216 0.975 1.000 190 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 6 FUT1(1), FUT3(3), FUT5(2), FUT6(3), ST3GAL3(4) 6006817 13 13 13 4 4 2 4 2 1 0 0.535 0.975 1.000 191 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(4), LPO(4), MPO(5), PRDX1(3), PRDX2(1), PRDX5(4), TPO(7), TYR(5) 13832951 33 30 33 7 7 7 6 6 7 0 0.273 0.977 1.000 192 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 CISH(2), IFNG(2), IFNGR1(2), JAK1(11), JAK2(7), PLA2G2A(1), PTPRU(10), REG1A(1), STAT1(4) 16474611 40 35 40 8 5 7 9 7 11 1 0.352 0.977 1.000 193 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(4), CDKN1A(1), EPO(1), EPOR(4), GRIN1(3), HIF1A(4), JAK2(7), NFKB1(5), NFKBIA(3), RELA(3) 17979768 35 31 35 5 6 13 3 5 8 0 0.118 0.978 1.000 194 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 126 ARAF(5), BID(3), BRAF(5), CASP3(1), CD244(3), CD48(2), FAS(1), FASLG(2), FCGR3A(3), HLA-A(3), HLA-B(3), HLA-C(6), HLA-G(1), HRAS(2), ICAM1(2), ICAM2(1), IFNA1(1), IFNA10(3), IFNA13(3), IFNA14(3), IFNA16(2), IFNA17(3), IFNA2(3), IFNA21(4), IFNA4(2), IFNA6(1), IFNA7(2), IFNA8(2), IFNAR1(2), IFNAR2(1), IFNG(2), IFNGR1(2), ITGAL(4), ITGB2(7), KIR2DL3(2), KIR3DL1(3), KIR3DL2(6), KLRC1(5), KLRC3(1), KLRD1(1), KLRK1(2), KRAS(6), LAT(1), LCK(2), LCP2(2), MAP2K1(5), MAP2K2(2), MAPK1(1), MAPK3(1), MICA(3), MICB(2), NCR1(3), NCR2(2), NFAT5(7), NFATC1(5), NFATC2(4), NFATC3(7), NFATC4(6), NRAS(2), PAK1(3), PIK3CA(351), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R1(15), PIK3R2(4), PIK3R3(3), PIK3R5(5), PLCG1(8), PLCG2(8), PPP3CA(5), PPP3CB(2), PPP3R1(1), PRF1(2), PRKCA(4), PRKCG(3), PTK2B(6), PTPN11(1), RAF1(4), SHC1(2), SHC2(2), SHC3(1), SHC4(5), SOS1(5), SOS2(6), SYK(4), TNFRSF10A(1), TNFRSF10B(1), TNFRSF10D(1), ULBP1(2), ULBP2(3), ULBP3(3), VAV1(6), VAV2(3), VAV3(7), ZAP70(3) 157848868 670 452 366 111 43 230 76 248 71 2 2.33e-08 0.978 1.000 195 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(11), AGT(3), AGTR1(4), AGTR2(2), BDKRB2(4), KNG1(4), NOS3(3), REN(1) 13603266 32 28 32 7 7 10 5 6 4 0 0.201 0.981 1.000 196 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(8), CKM(1), FBL(5), GPT(2), LDHA(2), LDHC(4), MAPK14(1), NCL(7) 13013931 30 27 30 6 5 9 7 4 5 0 0.315 0.982 1.000 197 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(3), CYP11A1(1), CYP11B2(4), CYP17A1(3), HSD11B1(3), HSD11B2(2), HSD3B1(3), HSD3B2(4) 9799872 23 22 22 6 2 7 6 6 2 0 0.322 0.983 1.000 198 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(3), HK1(3), HK2(5), HK3(5), IMPA2(4), ISYNA1(1), PGM1(5), PGM3(2), TGDS(3) 16304414 31 27 31 5 6 3 6 10 6 0 0.112 0.983 1.000 199 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(3), BMPR1A(1), BMPR1B(6), BMPR2(8) 8801986 18 16 17 7 1 2 4 5 6 0 0.893 0.983 1.000 200 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD4(4), CD8A(3), CSF1(5), CSF3(2), EPO(1), IL11(1), IL3(1), IL4(1), IL6(1), IL7(1) 8731251 20 19 20 5 3 7 4 1 5 0 0.424 0.984 1.000 201 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 31 APAF1(11), BID(3), BIRC2(3), BIRC3(4), CASP10(2), CASP3(1), CASP6(2), CASP7(2), CASP8(10), CASP9(2), CFLAR(1), CHUK(7), DFFA(4), DFFB(2), GAS2(3), LMNA(4), NFKB1(5), NFKBIA(3), RELA(3), RIPK1(5), SPTAN1(12), TNFRSF10A(1), TNFRSF10B(1), TNFRSF25(2), TNFSF12(3), TRAF2(1) 47238527 97 69 96 11 19 31 15 12 20 0 0.00204 0.985 1.000 202 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 7 CARS(4), CTH(3), GOT1(2), GOT2(1), LDHA(2), LDHC(4) 9369561 16 15 16 4 0 6 2 2 6 0 0.596 0.985 1.000 203 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT1(1), B3GNT2(2), B3GNT7(2), B4GALT1(3), B4GALT3(2), B4GALT4(2), CHST1(4), CHST2(4), CHST4(1), FUT8(3), ST3GAL1(2), ST3GAL2(2), ST3GAL3(4), ST3GAL4(2) 15878410 34 31 34 6 9 8 7 5 5 0 0.127 0.986 1.000 204 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(1), ALG5(5), B4GALT1(3), B4GALT3(2), B4GALT5(4), DDOST(2), DPAGT1(3), DPM1(4), FUT8(3), MAN1A1(6), MAN1B1(3), MGAT3(4), MGAT4A(3), MGAT4B(4), MGAT5(3), RPN1(4), RPN2(2), ST6GAL1(3) 26669546 59 41 59 9 8 18 13 10 9 1 0.0399 0.987 1.000 205 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 CDK5(2), CDK5R1(1), EGR1(3), HRAS(2), KLK2(3), MAP2K1(5), MAP2K2(2), MAPK1(1), MAPK3(1), NGFR(1), RAF1(4) 11233373 25 23 24 5 4 7 2 6 6 0 0.262 0.989 1.000 206 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(5), CDO1(3), CSAD(5), GAD1(3), GAD2(3), GGT1(4) 8099282 23 21 23 6 3 10 4 2 4 0 0.438 0.990 1.000 207 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 10 CASP3(1), CASP7(2), DFFA(4), DFFB(2), HMGB1(2), HMGB2(3), TOP2A(3), TOP2B(6) 15309441 23 17 22 2 0 10 3 5 5 0 0.162 0.991 1.000 208 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 42 CHUK(7), DAXX(2), EGF(5), EGFR(5), ETS1(3), ETS2(7), HRAS(2), IKBKB(5), JUN(3), MAP2K1(5), MAP2K3(3), MAP2K4(32), MAP2K6(1), MAP2K7(1), MAP3K1(80), MAP3K5(12), MAPK1(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8(2), NFKB1(5), NFKBIA(3), PPP2CA(3), PRKCA(4), PRKCD(5), PRKCE(8), PRKCG(3), PRKCH(3), PRKCQ(8), RAF1(4), RELA(3), RIPK1(5), SP1(6), TNFRSF1A(4), TNFRSF1B(2), TRAF2(1) 68970954 246 191 231 39 33 37 28 38 91 19 0.0615 0.991 1.000 209 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(1), PLCD1(3), PRKCA(4), TGM2(7) 6999927 15 13 15 7 3 4 1 1 6 0 0.857 0.992 1.000 210 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(3), RAB11A(3), RAB1A(2), RAB27A(1), RAB3A(2), RAB6A(4), RAB9A(1) 6242988 16 15 16 5 1 6 4 1 3 1 0.717 0.993 1.000 211 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(7), PNPO(2), PSAT1(1) 6836222 10 9 10 3 2 2 2 1 3 0 0.660 0.993 1.000 212 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(9), CS(2), MDH1(1), PC(10), PDHA1(3), SLC25A1(2), SLC25A11(2) 13022183 29 26 29 7 4 3 10 5 7 0 0.352 0.993 1.000 213 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(4), BLVRB(1), IL10RA(1), IL10RB(3), IL1A(1), IL6(1), JAK1(11), STAT1(4), STAT3(5), STAT5A(6) 17103884 37 32 37 7 5 8 9 9 6 0 0.171 0.994 1.000 214 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(4), APOBEC1(2), APOBEC2(2), APOBEC3A(2), APOBEC3B(2), APOBEC3C(2), APOBEC3G(3) 10670671 17 14 17 4 4 4 4 2 3 0 0.490 0.995 1.000 215 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 ANP32A(2), APEX1(3), CREBBP(15), DFFA(4), DFFB(2), GZMA(3), HMGB2(3), PRF1(2) 15299382 34 29 33 7 6 7 6 5 10 0 0.355 0.996 1.000 216 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RAN(1), RANBP2(14), RANGAP1(3) 12212797 18 16 18 3 1 7 2 3 5 0 0.602 0.996 1.000 217 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GSR(2), GSS(3), NFKB1(5), NOX1(4), RELA(3), SOD1(1), XDH(9) 14018124 27 26 27 5 5 7 2 8 5 0 0.253 0.996 1.000 218 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 GBA(2), GGT1(4), SHMT1(1), SHMT2(3) 8049711 10 9 10 3 3 3 1 2 1 0 0.632 0.996 1.000 219 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(6), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(3), ALDH9A1(1), UGDH(1) 11901798 16 16 15 3 3 2 4 2 5 0 0.376 0.997 1.000 220 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCL11(1), CCR3(2), CFL1(1), GNAQ(1), GNAS(11), GNB1(2), HRAS(2), LIMK1(7), MAP2K1(5), MAPK1(1), MAPK3(1), NOX1(4), PIK3C2G(8), PLCB1(12), PPP1R12B(4), PRKCA(4), PTK2(7), RAF1(4), ROCK2(9) 36498650 86 67 84 11 13 20 12 18 23 0 0.0327 0.997 1.000 221 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT1(2), OXCT1(5) 4921357 7 5 7 3 1 3 0 3 0 0 0.811 0.997 1.000 222 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(1), EPHX2(2), HSD3B7(1), RDH11(3), RDH12(2), RDH13(2), RDH14(2) 6730050 13 13 13 6 1 2 3 4 3 0 0.841 0.998 1.000 223 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(1), PLCG1(8), PRKCA(4), PTK2B(6) 9594274 19 18 19 8 3 5 3 2 6 0 0.857 0.998 1.000 224 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(11), ARHGDIB(1), BIRC2(3), BIRC3(4), CASP1(3), CASP10(2), CASP2(3), CASP3(1), CASP4(1), CASP6(2), CASP7(2), CASP8(10), CASP9(2), DFFA(4), DFFB(2), LMNA(4), LMNB1(2), LMNB2(3), PRF1(2) 27312147 62 49 61 10 5 19 11 9 18 0 0.148 0.998 1.000 225 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 CDC34(1), NRF1(3), UBE2A(2), UBE2D1(1), UBE2D2(3), UBE2D3(2), UBE2E1(1), UBE2E3(1), UBE2J1(3), UBE2J2(2), UBE2L3(1), UBE2L6(2), UBE3A(3) 14868641 25 23 25 5 2 7 7 4 5 0 0.445 0.998 1.000 226 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(4), GLUD1(2), GLUD2(3) 6379075 9 8 9 3 2 1 1 2 3 0 0.829 0.998 1.000 227 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 HRAS(2), JUN(3), MAP2K1(5), MAPK1(1), MAPK3(1), MYC(1), NFKB1(5), NFKBIA(3), PLCB1(12), PRKCA(4), RAF1(4), RELA(3) 21357975 44 36 44 8 10 10 4 10 10 0 0.171 0.998 1.000 228 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALT(1), TGDS(3), UGDH(1), UXS1(3) 5794111 8 7 8 3 2 4 1 1 0 0 0.783 0.998 1.000 229 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD28(2), CD3E(3), CD3G(3), IFNG(2), IL2RA(2), IL4(1), TGFB1(2), TGFB2(1), TGFB3(1), TGFBR1(4), TGFBR2(4), TGFBR3(4), TOB1(2) 15483408 31 28 31 7 6 8 4 9 4 0 0.380 0.998 1.000 230 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 4 CDK5(2), FOSB(2), GRIA2(3) 5077611 7 7 7 3 3 3 0 0 1 0 0.755 0.998 1.000 231 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAS1(5), ALAS2(7), GATA1(2), HBA2(2), HBB(1), HMBS(3), UROD(2), UROS(2) 11920638 24 20 23 6 5 6 3 6 4 0 0.525 0.999 1.000 232 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 16 CARS(4), CARS2(5), CDO1(3), CTH(3), GOT1(2), GOT2(1), LDHA(2), LDHC(4), SULT1B1(2), SULT1C2(1), SULT1C4(1), SULT4A1(2) 17561185 30 29 30 6 1 13 4 2 10 0 0.387 0.999 1.000 233 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 ASAH1(1), BFAR(3), BRAF(5), CREB1(1), CREB5(5), MAPK1(1), RAF1(4), SNX13(5), SRC(1), TERF2IP(3) 16727496 29 28 29 5 6 8 3 8 4 0 0.221 0.999 1.000 234 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(2), CYP2E1(2), NR1I3(2), PTGS1(5), PTGS2(6) 7605073 17 14 17 5 3 3 3 3 5 0 0.591 0.999 1.000 235 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP2(1), ACP5(3), ACP6(2), ACPP(6), ACPT(1), ENPP1(7), ENPP3(5), FLAD1(7), MTMR1(1), MTMR2(2), MTMR6(3), RFK(1), TYR(5) 21727513 44 37 43 8 8 12 11 7 6 0 0.162 0.999 1.000 236 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 AANAT(1), ACHE(3), CHAT(2), DBH(6), DDC(3), GAD1(3), GAD2(3), MAOA(2), PAH(3), PNMT(1), SLC18A3(3), TH(2), TPH1(2) 19308078 34 32 34 7 10 6 7 5 6 0 0.228 0.999 1.000 237 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDFT1(4), FDPS(5), GGPS1(2), IDI1(5), IDI2(1), SQLE(2) 6360825 19 15 18 5 3 9 3 1 3 0 0.647 0.999 1.000 238 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 AKR1A1(1), EHHADH(4), HADHA(2) 7034729 7 7 7 3 0 2 2 2 1 0 0.848 0.999 1.000 239 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(3), IFNG(2), IL12B(2), IL18(2) 4484252 9 9 9 4 1 1 1 5 1 0 0.878 1.000 1.000 240 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(1), GNAS(11), GNB1(2), PRKACB(1), PRKACG(3), PRKAR1A(4), PRKAR2A(2), PRKAR2B(2), PRKCA(4) 13312951 30 26 30 9 5 9 5 4 7 0 0.771 1.000 1.000 241 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 AKR1A1(1), EHHADH(4), HADH(2), HADHA(2), HSD17B10(1), HSD17B4(8), NTAN1(1), SIRT1(2), SIRT2(1), SIRT5(2), SIRT7(3), VNN2(7) 17034966 34 32 34 8 5 13 8 5 3 0 0.411 1.000 1.000 242 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 ATP6V0C(1), GGT1(4), SHMT1(1), SHMT2(3) 5978340 9 8 9 4 4 2 1 1 1 0 0.791 1.000 1.000 243 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(1), SEC61A2(3), SRP19(1), SRP54(1), SRP68(3), SRP72(2), SRPR(8) 10935626 19 17 18 5 1 5 1 6 6 0 0.586 1.000 1.000 244 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 12 CREB1(1), JUN(3), KEAP1(3), MAPK1(1), MAPK14(1), MAPK8(2), NFE2L2(3), PRKCA(4) 12291478 18 18 18 9 5 3 2 1 6 1 0.975 1.000 1.000 245 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CALM2(1), CAMK1(1), CAMK1G(5), ELK1(4), FPR1(3), GNB1(2), HRAS(2), MAP2K1(5), MAP2K2(2), MAP2K3(3), MAP2K6(1), MAP3K1(80), MAPK1(1), MAPK14(1), MAPK3(1), NCF1(1), NCF2(7), NFATC1(5), NFATC2(4), NFATC3(7), NFATC4(6), NFKB1(5), NFKBIA(3), PAK1(3), PIK3C2G(8), PLCB1(12), PPP3CA(5), PPP3CB(2), RAF1(4), RELA(3), SYT1(1) 54418119 188 148 179 31 18 36 23 30 63 18 0.123 1.000 1.000 246 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(4), ALDH1A2(1), RDH5(1) 5561748 6 5 6 9 0 1 2 0 3 0 1.000 1.000 1.000 247 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(4), ACO2(5), FH(3), IDH1(5), MDH1(1), SDHB(2), SUCLA2(1) 12996217 21 19 21 5 4 5 3 6 3 0 0.375 1.000 1.000 248 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(8), CAPN1(8), CDK5(2), CDK5R1(1), CSNK1A1(3), GSK3B(2), MAPT(3), PPP2CA(3) 13279794 30 26 30 7 5 11 2 6 6 0 0.420 1.000 1.000 249 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(23), ASAH1(1), CASP3(1), CERK(2), CREB1(1), CREB5(5), CXCL2(1), DAG1(2), EPHB2(5), GNAQ(1), ITPKA(1), ITPKB(8), JUN(3), MAP2K4(32), MAP2K7(1), MAPK1(1), MAPK10(4), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(8), MAPK9(1) 38723557 106 84 102 19 18 19 14 16 38 1 0.120 1.000 1.000 250 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 31 ANPEP(8), G6PD(4), GCLC(3), GCLM(2), GGT1(4), GPX2(1), GPX5(1), GSS(3), GSTA1(2), GSTA2(1), GSTA3(1), GSTA4(1), GSTM4(1), GSTO2(2), GSTP1(1), GSTT1(1), GSTZ1(1), IDH1(5), MGST3(2), PGD(3) 25970834 47 36 46 8 6 10 11 13 7 0 0.0810 1.000 1.000 251 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(7), MAPK14(1), MAPK8(2), NFKB1(5), RELA(3), TNFRSF13B(2), TNFSF13(3), TNFSF13B(1), TRAF2(1), TRAF3(3), TRAF5(3), TRAF6(4) 20742976 35 32 35 7 7 8 6 7 6 1 0.329 1.000 1.000 252 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 8 CAMK1(1), CAMK1G(5), HDAC9(4), MEF2A(6), MEF2C(4), MEF2D(3) 11839070 23 20 23 6 1 5 4 9 4 0 0.482 1.000 1.000 253 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAS1(5), ALAS2(7), HMBS(3), PPOX(5), UROD(2), UROS(2) 11225032 24 20 23 7 4 6 3 6 5 0 0.678 1.000 1.000 254 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(3), ACOX3(5), FADS2(7), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(2), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(1) 14934409 34 29 34 9 2 11 9 9 3 0 0.442 1.000 1.000 255 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(2), B4GALT7(1), HS3ST1(2), HS3ST2(4), HS3ST3A1(1), HS3ST3B1(1), XYLT1(4), XYLT2(5) 8231840 20 19 20 7 7 3 0 5 5 0 0.761 1.000 1.000 256 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(2), B4GALT7(1), HS3ST1(2), HS3ST2(4), HS3ST3A1(1), HS3ST3B1(1), XYLT1(4), XYLT2(5) 8231840 20 19 20 7 7 3 0 5 5 0 0.761 1.000 1.000 257 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(4), ACO2(5), CS(2), DLD(1), DLST(3), FH(3), IDH1(5), IDH3A(2), IDH3B(2), IDH3G(1), MDH1(1), PC(10), PCK1(5), SDHB(2), SUCLA2(1), SUCLG2(1) 29761523 48 38 48 9 9 14 9 11 5 0 0.0705 1.000 1.000 258 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CCR5(1), CD2(4), CD3E(3), CD3G(3), CD4(4), CXCR3(6), IFNG(2), IL12B(2), IL12RB1(7), IL12RB2(4), JAK2(7), STAT4(8), TYK2(7) 21419945 58 47 56 13 7 12 11 14 14 0 0.364 1.000 1.000 259 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(2), AKT2(4), AKT3(5), ARHGEF11(6), DLG4(1), GNA13(1), LPA(16), MAP2K4(32), MAP3K1(80), MAP3K5(12), MAPK8(2), NFKB1(5), NFKB2(5), NFKBIA(3), NFKBIB(1), NFKBIE(2), PDK1(2), PHKA2(13), PI3(1), PIK3CB(8), PLD1(7), PLD2(2), PLD3(2), PTK2(7), RDX(3), ROCK1(8), ROCK2(9), SERPINA4(4), SRF(1) 69483334 244 183 231 38 33 43 25 30 95 18 0.0476 1.000 1.000 260 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(3), GPI(3), HK1(3), PFKL(1), PGK1(7), PKLR(5), TPI1(2) 12811794 24 23 24 9 2 7 4 5 6 0 0.704 1.000 1.000 261 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 AKR1B10(1), DHRS2(4), DHRS3(1), DHRS7(1), HSD3B7(1), PON1(4), PON2(1), PON3(4), RDH11(3), RDH12(2), RDH13(2), RDH14(2) 12751231 26 21 26 8 0 5 5 11 5 0 0.598 1.000 1.000 262 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(1), IL22(2), IL22RA1(4), IL22RA2(3), JAK1(11), JAK2(7), JAK3(8), STAT1(4), STAT3(5), STAT5A(6), STAT5B(5), TYK2(7) 26043951 63 54 61 12 13 11 13 10 16 0 0.118 1.000 1.000 263 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 107 ABL1(6), ANAPC1(9), ANAPC10(1), ANAPC11(1), ANAPC4(4), ANAPC5(5), ANAPC7(4), ATM(23), ATR(13), BUB1(3), BUB1B(4), BUB3(3), CCNA2(4), CCNB1(3), CCNB3(14), CCND1(1), CCND2(2), CCND3(4), CCNE1(2), CCNE2(3), CCNH(2), CDC14A(3), CDC14B(1), CDC16(3), CDC20(1), CDC23(1), CDC25A(1), CDC25B(3), CDC25C(4), CDC6(4), CDC7(2), CDK2(2), CDK4(1), CDK6(2), CDK7(3), CDKN1A(1), CDKN1B(10), CDKN2A(1), CHEK1(2), CHEK2(5), CREBBP(15), CUL1(2), E2F1(5), E2F2(1), E2F3(3), EP300(13), ESPL1(13), GSK3B(2), HDAC1(6), HDAC2(2), MAD1L1(4), MAD2L1(4), MAD2L2(2), MCM2(3), MCM3(3), MCM4(5), MCM5(3), MCM6(4), MCM7(7), MDM2(3), PKMYT1(1), PLK1(2), PRKDC(24), PTTG1(1), RB1(22), RBL1(6), SFN(1), SKP1(1), SKP2(2), SMAD2(7), SMAD3(4), SMAD4(7), SMC1A(10), SMC1B(6), TFDP1(3), TGFB1(2), TGFB2(1), TGFB3(1), TP53(299), WEE1(4), YWHAB(2), YWHAG(1), YWHAZ(3) 193954291 671 436 527 91 93 123 85 136 231 3 5.11e-08 1.000 1.000 264 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AASDH(6), AASDHPPT(4), AASS(5) 10170315 15 13 15 5 2 5 3 2 3 0 0.827 1.000 1.000 265 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(2), PSMA2(1), PSMA3(4), PSMA5(2), PSMA6(2), PSMA7(1), PSMB4(1), PSMB5(2), PSMB6(2), PSMC3(3), PSMD14(1), RPN1(4), RPN2(2), UBE2A(2), UBE3A(3) 19234805 32 29 32 7 4 11 2 8 6 1 0.403 1.000 1.000 266 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(2), CLOCK(3), CRY1(2), CRY2(3), CSNK1E(4), PER1(9) 11829710 23 19 23 7 2 8 4 5 4 0 0.763 1.000 1.000 267 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(9), ACO1(4), ACO2(5), ACSS1(1), ACSS2(2), FH(3), IDH1(5), MDH1(1), SUCLA2(1) 19225401 31 26 31 8 4 6 9 7 5 0 0.393 1.000 1.000 268 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(4), ALDH1A2(1), ALDH1A3(6), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(3), ALDH9A1(1) 11274200 20 19 19 9 3 2 6 2 7 0 0.908 1.000 1.000 269 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(4), ALDH1A2(1), ALDH1A3(6), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(3), ALDH9A1(1) 11274200 20 19 19 9 3 2 6 2 7 0 0.908 1.000 1.000 270 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(1), ACADS(2), ACADVL(4), ACSL1(3), ACSL3(3), ACSL4(5), CPT1A(6), CPT2(5), EHHADH(4), HADHA(2), SCP2(1), SLC25A20(4) 24026726 40 31 40 8 6 9 9 9 7 0 0.190 1.000 1.000 271 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AASDHPPT(4), AASS(5) 6940483 9 8 9 5 2 3 2 1 1 0 0.938 1.000 1.000 272 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 A4GALT(1), FUT1(1), GBGT1(2), GLA(5), HEXA(3), HEXB(3), ST3GAL1(2), ST3GAL2(2), ST3GAL4(2), ST8SIA1(1) 13871665 22 20 22 6 3 9 3 4 3 0 0.528 1.000 1.000 273 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(1), ADH4(1), ADH5(5), ADH6(2), ADH7(3), ADHFE1(2), ALDH1A3(6), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(3), ALDH9A1(1) 19232177 29 27 28 7 5 5 11 3 5 0 0.403 1.000 1.000 274 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(4), GBA(2), LPO(4), MPO(5), TPO(7) 11996711 22 20 22 6 6 6 1 4 5 0 0.468 1.000 1.000 275 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(5), ADRB2(2), CFTR(14), GNAS(11), PRKACB(1), PRKACG(3), PRKAR1A(4), PRKAR2A(2), PRKAR2B(2), SLC9A3R1(3) 17778779 47 35 47 10 12 12 7 7 9 0 0.278 1.000 1.000 276 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT1(2), BDH1(1), HMGCS1(6), HMGCS2(3), OXCT1(5), OXCT2(5) 10449597 22 16 20 7 5 7 1 7 2 0 0.679 1.000 1.000 277 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(4), CHPT1(4), HEMK1(2), LCMT1(1), LCMT2(10), METTL2B(4), PCYT1A(2), PCYT1B(6), PRMT2(2), PRMT3(3), PRMT5(5), PRMT6(2), PRMT7(3), PRMT8(4), WBSCR22(2) 19619853 54 45 54 12 5 20 13 8 7 1 0.289 1.000 1.000 278 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 CREB1(1), HRAS(2), PTK2B(6), SHC1(2), SOS1(5), SRC(1) 12359387 17 17 17 6 3 4 3 3 4 0 0.762 1.000 1.000 279 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 FABP6(1), LDLR(4), NR0B2(2), NR1H3(2), NR1H4(4), RXRA(2) 7282015 15 15 15 8 4 4 2 4 1 0 0.926 1.000 1.000 280 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CHUK(7), CREBBP(15), EP300(13), HDAC3(1), IKBKB(5), NFKB1(5), NFKBIA(3), RELA(3), RIPK1(5), TNFRSF1A(4), TNFRSF1B(2), TRAF6(4) 31306496 67 52 66 12 16 16 11 10 14 0 0.105 1.000 1.000 281 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(3), ADSS(3), IMPDH1(2), POLB(1), POLD1(5), POLG(7), PRPS2(1), RRM1(4), SRM(4) 17662458 30 27 29 8 7 7 7 1 7 1 0.589 1.000 1.000 282 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 ACAT1(2), CCL2(1), CSF1(5), IL6(1), LDLR(4), LPL(1) 7495964 14 14 14 7 2 5 4 2 1 0 0.897 1.000 1.000 283 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(2), PSMA2(1), PSMA3(4), PSMA5(2), PSMA6(2), PSMA7(1), PSMB10(1), PSMB4(1), PSMB5(2), PSMB6(2) 11752676 18 18 18 6 2 8 0 5 3 0 0.693 1.000 1.000 284 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 MTMR1(1), MTMR2(2), MTMR6(3), NFS1(1), THTPA(3), TPK1(2) 9215377 12 11 12 5 2 7 1 1 1 0 0.907 1.000 1.000 285 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG12(1), ATG3(2), ATG5(3), ATG7(5), GABARAP(1), IFNA1(1), IFNA10(3), IFNA13(3), IFNA14(3), IFNA16(2), IFNA17(3), IFNA2(3), IFNA21(4), IFNA4(2), IFNA6(1), IFNA7(2), IFNA8(2), IFNG(2), PIK3C3(6), PIK3R4(10), PRKAA1(3), PRKAA2(2), ULK1(4), ULK2(5), ULK3(4) 30239276 77 59 77 16 5 31 16 18 7 0 0.202 1.000 1.000 286 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 11 BPNT1(2), CHST11(1), PAPSS1(2), PAPSS2(2), SULT1A1(1), SULT1A2(2), SULT1E1(3), SULT2B1(2), SUOX(4) 12350348 19 17 19 9 5 4 4 3 3 0 0.939 1.000 1.000 287 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(2), PSMA2(1), PSMA3(4), PSMA5(2), PSMA6(2), PSMA7(1), PSMB4(1), PSMB5(2), PSMB6(2), PSMC3(3), PSMD1(9), PSMD11(3), PSMD12(3), PSMD2(2), PSMD6(3) 23401693 40 35 40 9 6 19 2 6 7 0 0.372 1.000 1.000 288 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(11), BIRC2(3), BIRC3(4), CASP10(2), CASP3(1), CASP7(2), CASP8(10), CASP9(2), DFFA(4), DFFB(2), PRF1(2), SCAP(1), SREBF1(3), SREBF2(5) 24971072 52 41 51 12 3 19 10 5 15 0 0.334 1.000 1.000 289 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACAA1(1), ACOX1(3), ACOX3(5), ELOVL5(5), ELOVL6(4), FADS1(3), FADS2(7), FASN(14), HADHA(2), SCD(1) 19501846 45 38 45 12 4 16 10 7 8 0 0.284 1.000 1.000 290 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ERBB4(13), NRG2(4), NRG3(6), PRKCA(4), PSEN1(2) 13148729 29 26 29 9 0 12 6 7 4 0 0.774 1.000 1.000 291 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 16 CD28(2), CD86(4), HLA-DRB1(10), IFNG(2), IFNGR1(2), IL12B(2), IL12RB1(7), IL12RB2(4), IL18(2), IL18R1(4), IL2RA(2), IL4(1), IL4R(6) 17624026 48 41 48 13 3 12 13 15 5 0 0.544 1.000 1.000 292 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPL(1), ALPP(3), ALPPL2(2), FPGS(4), GCH1(1) 8308147 11 10 11 5 4 1 3 2 1 0 0.770 1.000 1.000 293 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 26 BAG4(1), BIRC2(3), BIRC3(4), CASP3(1), CASP8(10), CFLAR(1), JUN(3), MAP2K4(32), MAP3K3(1), MAP3K7(3), NFKB1(5), NFKB2(5), NFKBIA(3), NFKBIB(1), NFKBIE(2), NR2C2(1), RALBP1(3), RIPK1(5), TNFAIP3(3), TNFRSF1A(4), TNFRSF1B(2), TRAF2(1) 36506405 94 80 89 20 15 20 13 10 36 0 0.288 1.000 1.000 294 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 12 FUCA1(1), FUCA2(3), GLB1(4), HEXA(3), HEXB(3), LCT(17), MAN2C1(6), MANBA(5), NEU1(1), NEU3(2) 21680435 45 40 45 11 5 17 8 8 7 0 0.380 1.000 1.000 295 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(3), GCK(3), GFPT1(3), GNE(5), GNPDA2(2), HEXA(3), HEXB(3), HK1(3), HK2(5), HK3(5), PGM3(2), UAP1(3) 24458265 40 35 40 9 7 13 5 11 4 0 0.258 1.000 1.000 296 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(2), HADH(2), HADHA(2), HADHB(3), HSD17B10(1), HSD17B4(8), PPT1(1), PPT2(3) 11920143 22 19 22 7 4 10 5 2 1 0 0.628 1.000 1.000 297 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CCNB1(3), CDC25A(1), CDC25B(3), CDC25C(4), PRKCA(4), PTPRA(6), SRC(1) 13174999 22 21 22 7 4 9 1 4 4 0 0.706 1.000 1.000 298 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(2), GLB1(4), HEXA(3), HEXB(3), LCT(17), ST3GAL1(2), ST3GAL2(2), ST3GAL5(2), ST6GALNAC3(4), ST6GALNAC4(1), ST6GALNAC5(2), ST6GALNAC6(1), ST8SIA1(1) 22874817 44 40 44 11 7 13 9 10 5 0 0.356 1.000 1.000 299 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CSF3(2), EPO(1), FLT3(4), IL11(1), IL1A(1), IL3(1), IL6(1), KITLG(3), TGFB1(2), TGFB2(1), TGFB3(1) 12176022 18 18 18 6 5 2 5 4 2 0 0.707 1.000 1.000 300 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 DLL1(5), FURIN(3), NOTCH1(8), PSEN1(2) 11146319 18 17 18 6 4 1 8 2 3 0 0.720 1.000 1.000 301 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 21 ALDH1A3(6), ALDH3A1(3), ALDH3B2(4), AOC2(6), AOC3(3), DDC(3), EPX(4), GOT1(2), GOT2(1), HPD(4), LPO(4), MAOA(2), MAOB(4), MPO(5), PRDX1(3), PRDX2(1), PRDX5(4), TAT(3), TPO(7) 30156919 69 51 68 16 13 14 12 15 15 0 0.228 1.000 1.000 302 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 107 ACTN1(5), ACTN2(10), ACTN4(7), ARHGAP5(12), BCAR1(6), CD99(4), CDH5(1), CLDN1(1), CLDN10(2), CLDN11(1), CLDN14(1), CLDN15(1), CLDN16(2), CLDN17(2), CLDN18(2), CLDN19(2), CLDN2(1), CLDN22(2), CLDN4(1), CLDN6(6), CTNNA1(7), CTNNA2(14), CTNNA3(6), CTNNB1(2), CTNND1(5), CXCR4(3), CYBB(2), ESAM(3), EZR(1), F11R(4), GNAI1(2), GNAI2(2), GNAI3(1), ICAM1(2), ITGA4(6), ITGAL(4), ITGAM(6), ITGB1(5), ITGB2(7), ITK(7), MAPK13(1), MAPK14(1), MLLT4(19), MMP2(3), MMP9(3), MSN(4), MYL5(3), MYL7(1), MYL9(1), NCF1(1), NCF2(7), NCF4(3), NOX1(4), NOX3(2), OCLN(3), PIK3CA(351), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R1(15), PIK3R2(4), PIK3R3(3), PIK3R5(5), PLCG1(8), PLCG2(8), PRKCA(4), PRKCG(3), PTK2(7), PTK2B(6), PTPN11(1), RAP1A(2), RAP1B(1), RAPGEF3(2), RAPGEF4(5), RASSF5(4), RHOA(6), ROCK1(8), ROCK2(9), SIPA1(5), TXK(3), VAV1(6), VAV2(3), VAV3(7), VCAM1(7), VCL(6) 175815213 722 464 420 127 65 216 76 263 100 2 6.51e-07 1.000 1.000 303 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(2), CYP2A13(8), CYP2A6(1), CYP2A7(1), NAT1(2), XDH(9) 11681368 23 20 23 9 4 4 5 7 3 0 0.815 1.000 1.000 304 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 ALDOA(5), CTSD(1), ESR1(5), GREB1(6), MTA3(2), PDZK1(1), TUBA8(1) 14259200 21 20 21 8 4 9 2 2 4 0 0.667 1.000 1.000 305 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 22 ARSA(2), ARSB(3), ARSE(4), ASAH1(1), GAL3ST1(5), GALC(1), GBA(2), GLA(5), GLB1(4), LCT(17), NEU1(1), NEU3(2), PPAP2A(2), PPAP2C(1), SMPD1(2), SPTLC1(4), SPTLC2(6), UGCG(1) 32171469 63 51 61 14 13 16 11 17 6 0 0.164 1.000 1.000 306 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 A4GALT(1), B3GALNT1(1), B3GALT5(2), FUT1(1), GBGT1(2), GLA(5), HEXA(3), HEXB(3), ST3GAL1(2), ST3GAL2(2), ST8SIA1(1) 14722301 23 21 23 7 4 10 2 4 3 0 0.607 1.000 1.000 307 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(5), F2(2), F2R(4), F5(25), F7(2), FGA(7), FGB(1), FGG(7), PROC(3), PROS1(4), SERPINC1(6), TFPI(3) 23272902 69 55 69 16 9 20 17 14 9 0 0.339 1.000 1.000 308 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(5), CS(2), FH(3), MDH1(1), OGDH(7), SUCLA2(1) 13846649 19 17 19 7 2 7 4 3 3 0 0.725 1.000 1.000 309 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(1), ACAA2(2), ACAT1(2), EHHADH(4), HADHA(2), HADHB(3) 12171347 14 14 14 6 2 3 4 4 1 0 0.824 1.000 1.000 310 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA1(5), ANXA3(3), ANXA4(3), ANXA5(1), ANXA6(5), CYP11A1(1), EDN1(5), EDNRA(3), EDNRB(2), HPGD(1), HSD11B1(3), HSD11B2(2), PLA2G4A(7), PTGDR(2), PTGDS(2), PTGER2(3), PTGER4(1), PTGFR(1), PTGIS(4), PTGS1(5), PTGS2(6), S100A6(1), TBXAS1(3) 29107623 69 50 69 15 12 19 9 16 13 0 0.165 1.000 1.000 311 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 CISH(2), JAK1(11), JAK2(7), JAK3(8), PIAS1(3), PIAS3(2), PTPRU(10), REG1A(1), SOAT1(2) 19655267 46 39 46 11 9 8 11 6 11 1 0.418 1.000 1.000 312 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(3), ADCY1(5), CAP1(2), CCNB1(3), CDC25C(4), GNAI1(2), GNAS(11), GNB1(2), HRAS(2), MAPK1(1), MAPK3(1), MYT1(10), PRKACB(1), PRKACG(3), PRKAR1A(4), PRKAR2A(2), PRKAR2B(2), RPS6KA1(6), SRC(1) 28263217 65 55 64 15 16 18 10 9 11 1 0.285 1.000 1.000 313 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 HRAS(2), MMP14(4), MMP2(3), MMP9(3), RECK(2), TIMP1(1), TIMP3(3) 10808870 18 16 18 9 4 6 2 5 1 0 0.902 1.000 1.000 314 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(2), F2R(4), GNAI1(2), GNB1(2), HRAS(2), ITGA1(6), ITGB1(5), MAP2K1(5), MAPK1(1), MAPK3(1), PLA2G4A(7), PLCB1(12), PRKCA(4), PTGS1(5), PTK2(7), RAF1(4), SRC(1), SYK(4), TBXAS1(3) 34849949 77 55 77 15 14 19 18 18 8 0 0.102 1.000 1.000 315 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(7), ALDH4A1(3), ALDH5A1(2), CAD(15), CPS1(12), EPRS(11), GAD1(3), GAD2(3), GCLC(3), GCLM(2), GFPT1(3), GLS(4), GLUD1(2), GLUL(3), GMPS(5), GOT1(2), GOT2(1), GPT(2), GPT2(3), GSS(3), NADSYN1(2), PPAT(5), QARS(10) 47706901 106 73 106 21 9 36 23 21 17 0 0.0800 1.000 1.000 316 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(1), ALOX12(7), ALOX15(4), ALOX5(3), CBR1(3), CYP4F2(3), CYP4F3(2), EPX(4), GGT1(4), LPO(4), LTA4H(2), MPO(5), PLA2G1B(1), PLA2G2A(1), PLA2G2E(1), PLA2G3(2), PLA2G4A(7), PLA2G6(1), PRDX1(3), PRDX2(1), PRDX5(4), PTGDS(2), PTGES2(2), PTGIS(4), PTGS1(5), PTGS2(6), TBXAS1(3), TPO(7) 39640699 92 67 92 18 17 22 18 19 16 0 0.0357 1.000 1.000 317 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(3), ELK1(4), HRAS(2), IL2RA(2), IL2RB(3), IL2RG(2), JAK1(11), JAK3(8), JUN(3), LCK(2), MAP2K1(5), MAPK3(1), MAPK8(2), RAF1(4), SHC1(2), SOS1(5), STAT5A(6), STAT5B(5), SYK(4) 33103412 74 60 74 16 15 16 13 15 15 0 0.146 1.000 1.000 318 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOA(5), ALDOB(3), ALDOC(2), FBP1(2), G6PD(4), GPI(3), H6PD(3), PFKM(8), PFKP(6), PGD(3), PGLS(3), PGM1(5), PGM3(2), PRPS2(1), RBKS(1), TAL1(1), TALDO1(2), TKT(3) 27882672 57 44 55 14 10 12 8 13 14 0 0.281 1.000 1.000 319 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 36 ANPEP(8), G6PD(4), GCLC(3), GCLM(2), GGT1(4), GPX2(1), GPX5(1), GSR(2), GSS(3), GSTA1(2), GSTA2(1), GSTA3(1), GSTA4(1), GSTA5(2), GSTK1(1), GSTM4(1), GSTO2(2), GSTP1(1), GSTT1(1), GSTZ1(1), IDH1(5), MGST3(2), TXNDC12(1) 28949663 50 38 49 10 5 10 12 13 10 0 0.152 1.000 1.000 320 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNA1(1), IFNG(2), IL12B(2), IL15(3), IL16(2), IL18(2), IL1A(1), IL3(1), IL4(1), IL6(1), LTA(2) 13790104 18 15 18 8 2 5 3 7 1 0 0.875 1.000 1.000 321 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 46 APAF1(11), BAD(1), BAX(3), BCL2A1(1), BCL2L1(1), BCL2L2(1), BOK(1), CASP1(3), CASP10(2), CASP2(3), CASP3(1), CASP4(1), CASP6(2), CASP7(2), CASP8(10), CASP9(2), CD40(2), CD40LG(1), DAXX(2), DFFA(4), DFFB(2), FAS(1), FASLG(2), IKBKE(6), LTA(2), MCL1(1), NFKB1(5), NFKBIA(3), NGFR(1), NR3C1(3), NTRK1(8), PTPN13(16), RIPK1(5), TFG(2), TNFRSF1A(4), TNFRSF1B(2), TRAF1(2), TRAF2(1), TRAF3(3), TRAF6(4) 61532723 127 84 125 24 16 40 19 21 30 1 0.0550 1.000 1.000 322 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCR1(3), CCR2(4), CCR3(2), CCR4(1), CCR5(1), CCR7(4), CD28(2), CD4(4), CXCR3(6), CXCR4(3), IFNG(2), IFNGR1(2), IL12B(2), IL12RB1(7), IL12RB2(4), IL18R1(4), IL4(1), IL4R(6), TGFB1(2), TGFB2(1), TGFB3(1) 29283586 62 44 62 17 6 13 13 21 9 0 0.463 1.000 1.000 323 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(4), HRAS(2), IL3(1), IL3RA(3), JAK2(7), MAP2K1(5), MAPK3(1), RAF1(4), SHC1(2), SOS1(5), STAT5A(6), STAT5B(5) 25105744 45 42 45 10 10 11 6 7 11 0 0.212 1.000 1.000 324 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(5), EGFR(5), ERBB3(17), NRG1(2), UBE2D1(1) 14760606 30 26 28 9 4 7 10 7 2 0 0.660 1.000 1.000 325 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ACY1(2), AGMAT(4), ALDH18A1(4), ALDH1A3(6), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(3), ALDH9A1(1), AMD1(2), AOC2(6), AOC3(3), ARG1(3), ARG2(2), ASL(4), ASS1(1), CPS1(12), GATM(3), MAOA(2), MAOB(4), NAGS(1), OTC(3), SAT1(3), SAT2(2), SRM(4) 41650067 80 60 79 17 7 14 26 18 15 0 0.133 1.000 1.000 326 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 CISH(2), IL6(1), IL6R(4), JAK1(11), JAK2(7), JAK3(8), PIAS3(2), PTPRU(10), REG1A(1), SRC(1), STAT3(5) 21589592 52 42 52 13 9 6 13 10 13 1 0.453 1.000 1.000 327 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP2(1), ACP5(3), ACP6(2), ACPP(6), ACPT(1), ALPL(1), ALPP(3), ALPPL2(2), CMBL(1), CYP3A4(4), CYP3A43(3), CYP3A5(2), CYP3A7(5), DHRS2(4), DHRS3(1), DHRS7(1), PON1(4), PON2(1), PON3(4) 25328886 49 36 48 12 7 13 8 17 4 0 0.278 1.000 1.000 328 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(8), ABAT(7), ADSL(3), ADSS(3), AGXT(1), AGXT2(2), ASL(4), ASNS(3), ASPA(4), CAD(15), CRAT(6), DARS(3), DDO(1), GAD1(3), GAD2(3), GOT1(2), GOT2(1), GPT(2), GPT2(3), NARS(1), PC(10) 36950181 85 66 85 20 12 23 23 12 15 0 0.142 1.000 1.000 329 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(1), ASNS(3), CA1(2), CA12(1), CA14(4), CA2(2), CA4(1), CA5B(3), CA6(1), CA9(5), CPS1(12), CTH(3), GLS(4), GLUD1(2), GLUL(3), HAL(7) 27221326 54 46 54 13 5 12 17 11 9 0 0.373 1.000 1.000 330 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(3), CBS(1), CTH(3), GGT1(4), MARS(9), MARS2(1), MAT1A(2), MAT2B(2), PAPSS1(2), PAPSS2(2), SCLY(3), SEPHS1(2) 17381876 34 28 33 10 7 7 9 5 6 0 0.448 1.000 1.000 331 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOA(5), ALDOB(3), ALDOC(2), DERA(2), FBP1(2), G6PD(4), GPI(3), H6PD(3), PFKL(1), PFKM(8), PFKP(6), PGD(3), PGLS(3), PGM1(5), PGM3(2), PRPS2(1), RBKS(1), TALDO1(2), TKT(3), TKTL1(3), TKTL2(3) 33780432 65 50 63 16 10 13 10 14 18 0 0.289 1.000 1.000 332 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(15), EP300(13), ESR1(5), MAPK1(1), MAPK3(1), PELP1(6), SRC(1) 21335176 42 36 42 11 8 9 8 9 8 0 0.541 1.000 1.000 333 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 31 ADH1A(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(2), ALDH1A3(6), ALDH3A1(3), ALDH3B2(4), AOC2(6), AOC3(3), AOX1(7), DBH(6), DCT(4), DDC(3), FAH(2), GOT1(2), GOT2(1), GSTZ1(1), HGD(4), HPD(4), MAOA(2), MAOB(4), PNMT(1), TAT(3), TH(2), TPO(7), TYR(5) 43688686 89 67 88 21 20 16 23 15 15 0 0.190 1.000 1.000 334 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(4), ACO2(5), CS(2), GRHPR(2), HAO1(5), HAO2(2), MDH1(1), MTHFD1(9), MTHFD1L(5) 18570702 35 31 35 10 6 14 5 3 7 0 0.362 1.000 1.000 335 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(10), GABBR1(4), GPRC5A(1), GPRC5B(1), GPRC5C(2), GPRC5D(1), GRM1(9), GRM2(3), GRM3(9), GRM4(3), GRM5(4), GRM7(2), GRM8(5) 27432770 54 46 54 15 14 14 11 7 8 0 0.193 1.000 1.000 336 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS2(4), DHRS3(1), DHRS7(1), ESCO1(4), ESCO2(1), PNPLA3(3), SH3GLB1(2) 23535328 16 14 16 8 1 5 1 6 2 1 0.965 1.000 1.000 337 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 AMT(1), ASNS(3), CA1(2), CA12(1), CA13(1), CA14(4), CA2(2), CA4(1), CA5B(3), CA6(1), CA9(5), CPS1(12), CTH(3), GLS(4), GLUD1(2), GLUD2(3), GLUL(3), HAL(7) 30342988 58 50 58 14 7 13 17 12 9 0 0.355 1.000 1.000 338 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(5), CS(2), DLAT(2), DLD(1), DLST(3), FH(3), IDH3A(2), IDH3B(2), IDH3G(1), MDH1(1), OGDH(7), PC(10), PDHA1(3), PDHA2(4), PDHB(1), PDHX(3), PDK1(2), PDK2(1), PDK4(4), PDP2(2), SDHB(2), SUCLA2(1), SUCLG2(1) 41013126 63 50 63 14 13 15 13 15 7 0 0.129 1.000 1.000 339 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CHUK(7), CREBBP(15), DUSP1(1), EP300(13), IKBKB(5), MAP2K3(3), MAP2K6(1), MAP3K7(3), MAPK14(1), MYD88(1), NFKB1(5), NFKBIA(3), NR3C1(3), RELA(3), TGFBR1(4), TGFBR2(4), TLR2(3) 42170808 75 57 75 16 16 18 12 13 16 0 0.204 1.000 1.000 340 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(2), IL2RG(2), IL4(1), IL4R(6), IRS1(4), JAK1(11), JAK3(8), RPS6KB1(4), SHC1(2), STAT6(7) 19984208 47 38 47 13 5 12 10 8 12 0 0.522 1.000 1.000 341 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(3), ARG1(3), ARG2(2), ASL(4), ASS1(1), CKB(1), CKM(1), CKMT1A(1), CKMT1B(1), CKMT2(5), CPS1(12), DAO(1), EPRS(11), GAMT(1), GATM(3), GLUD1(2), GLUD2(3), GOT1(2), GOT2(1), LAP3(2), NOS1(13), NOS3(3), OAT(2), OTC(3), P4HA1(3), P4HA2(4), P4HA3(3), PARS2(2), PRODH(2), PYCR2(2), PYCRL(1), RARS(5), RARS2(3) 50728566 106 77 105 22 20 29 32 13 12 0 0.0580 1.000 1.000 342 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 20 CSNK2A1(3), ELK1(4), HRAS(2), IL6(1), IL6R(4), IL6ST(9), JAK1(11), JAK2(7), JAK3(8), JUN(3), MAP2K1(5), MAPK3(1), PTPN11(1), RAF1(4), SHC1(2), SOS1(5), SRF(1), STAT3(5) 33543120 76 59 76 18 12 14 16 17 17 0 0.344 1.000 1.000 343 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(8), AARS2(5), ABAT(7), ACY3(3), ADSL(3), ADSS(3), ADSSL1(1), AGXT(1), AGXT2(2), ASL(4), ASNS(3), ASPA(4), ASS1(1), CAD(15), CRAT(6), DARS(3), DARS2(2), DDO(1), DLAT(2), DLD(1), GAD1(3), GAD2(3), GOT1(2), GOT2(1), GPT(2), GPT2(3), NARS(1), NARS2(2), PC(10), PDHA1(3), PDHA2(4), PDHB(1) 53692519 110 85 110 24 19 27 29 15 20 0 0.0927 1.000 1.000 344 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(3), GALNS(2), GLB1(4), GNS(2), GUSB(6), HEXA(3), HEXB(3), IDS(2), IDUA(1), LCT(17), NAGLU(1) 20198583 44 40 44 13 8 12 7 11 6 0 0.592 1.000 1.000 345 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(5), ADRB2(2), GNAS(11), PLCE1(15), PRKACB(1), PRKACG(3), PRKAR1A(4), PRKAR2A(2), PRKAR2B(2), RAP2B(2) 20212950 47 41 47 12 11 9 9 7 11 0 0.524 1.000 1.000 346 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOA(5), ALDOB(3), ALDOC(2), DLAT(2), DLD(1), ENO2(1), ENO3(2), FBP1(2), G6PC(2), GAPDH(1), GAPDHS(2), GCK(3), GOT1(2), GOT2(1), GPI(3), HK1(3), HK2(5), HK3(5), LDHA(2), LDHC(4), MDH1(1), PC(10), PCK1(5), PDHA1(3), PDHA2(4), PDHB(1), PDHX(3), PFKL(1), PFKM(8), PFKP(6), PGAM2(1), PGK1(7), PGK2(1), PKLR(5), TNFAIP1(1), TPI1(2) 60145134 110 82 108 25 16 29 20 23 22 0 0.0761 1.000 1.000 347 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPLD1(5), PGAP1(10), PIGA(5), PIGB(2), PIGG(6), PIGL(1), PIGM(3), PIGN(4), PIGO(3), PIGQ(3), PIGS(2), PIGT(4), PIGV(2), PIGW(3), PIGZ(3) 35481889 56 44 56 15 6 19 14 12 5 0 0.302 1.000 1.000 348 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(3), GALNS(2), GLB1(4), GNS(2), GUSB(6), HEXA(3), HEXB(3), HGSNAT(6), HPSE(6), HPSE2(5), HYAL2(3), IDS(2), IDUA(1), LCT(17), NAGLU(1), SPAM1(4) 28977154 68 60 69 19 12 20 10 15 11 0 0.485 1.000 1.000 349 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(4), ACO2(5), AFMID(1), CS(2), GRHPR(2), HAO1(5), HAO2(2), MDH1(1), MTHFD1(9), MTHFD1L(5) 19498658 36 32 36 11 6 14 5 4 7 0 0.439 1.000 1.000 350 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(3), CARM1(4), CBS(1), CTH(3), GGT1(4), HEMK1(2), LCMT1(1), LCMT2(10), MARS(9), MARS2(1), MAT1A(2), MAT2B(2), METTL2B(4), PAPSS1(2), PAPSS2(2), PRMT2(2), PRMT3(3), PRMT5(5), PRMT6(2), PRMT7(3), PRMT8(4), SCLY(3), SEPHS1(2), SEPHS2(3), WBSCR22(2) 34711513 79 60 78 21 13 24 20 9 12 1 0.305 1.000 1.000 351 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(4), CALCR(2), CALCRL(3), CD97(9), CRHR1(3), CRHR2(1), ELTD1(10), EMR1(5), EMR2(8), GHRHR(4), GIPR(1), GLP1R(2), GLP2R(3), GPR64(9), LPHN1(4), LPHN2(11), LPHN3(6), VIPR1(1), VIPR2(3) 39743269 89 69 89 26 9 26 15 17 21 1 0.428 1.000 1.000 352 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(7), ALDH4A1(3), ALDH5A1(2), CAD(15), CPS1(12), EARS2(3), EPRS(11), GAD1(3), GAD2(3), GCLC(3), GCLM(2), GFPT1(3), GFPT2(9), GLS(4), GLUD1(2), GLUD2(3), GLUL(3), GMPS(5), GNPNAT1(2), GOT1(2), GOT2(1), GPT(2), GPT2(3), GSR(2), GSS(3), NADSYN1(2), NAGK(1), PPAT(5), QARS(10) 56873689 126 85 125 28 13 39 25 26 23 0 0.143 1.000 1.000 353 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ACY1(2), ALDH18A1(4), ARG1(3), ARG2(2), ASL(4), CKB(1), CKM(1), CKMT1A(1), CKMT1B(1), CKMT2(5), CPS1(12), GAMT(1), GATM(3), GLUD1(2), NAGS(1), OAT(2), OTC(3) 24789867 48 40 48 13 4 11 18 9 6 0 0.423 1.000 1.000 354 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOA(5), ALDOB(3), ALDOC(2), FBP1(2), GOT1(2), GOT2(1), GPT(2), GPT2(3), MDH1(1), ME3(4), PGK1(7), PGK2(1), PKLR(5), TKT(3), TKTL1(3), TKTL2(3), TPI1(2) 28508625 49 43 49 14 9 16 9 7 8 0 0.356 1.000 1.000 355 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(3), ELK1(4), EPO(1), EPOR(4), HRAS(2), JAK2(7), JUN(3), MAP2K1(5), MAPK3(1), MAPK8(2), PLCG1(8), RAF1(4), SHC1(2), SOS1(5), STAT5A(6), STAT5B(5) 30787241 62 54 62 16 15 17 5 10 15 0 0.388 1.000 1.000 356 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 ATF1(3), BAD(1), BRAF(5), CREB1(1), CREB5(5), DUSP4(1), DUSP6(1), DUSP9(2), EEF2K(6), MAP2K1(5), MAP2K2(2), MAP3K8(4), MAPK1(1), MAPK3(1), MKNK1(2), MKNK2(4), MOS(3), NFKB1(5), RAP1A(2), RPS6KA1(6), RPS6KA2(5), RPS6KA3(8), SHC1(2), SOS1(5), SOS2(6), TRAF3(3) 42269801 89 68 88 21 16 22 8 20 22 1 0.271 1.000 1.000 357 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(9), ACO1(4), ACO2(5), CLYBL(3), CS(2), DLD(1), DLST(3), FH(3), IDH1(5), IDH3A(2), IDH3B(2), IDH3G(1), MDH1(1), OGDH(7), OGDHL(6), PC(10), PCK1(5), PCK2(4), SDHB(2), SUCLA2(1), SUCLG2(1) 43207811 77 62 77 20 15 16 20 17 9 0 0.232 1.000 1.000 358 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(2), ALDOA(5), ALDOB(3), ALDOC(2), FBP1(2), FPGT(1), GCK(3), GMDS(2), GMPPA(1), HK1(3), HK2(5), HK3(5), KHK(4), MPI(2), PFKFB3(4), PFKFB4(3), PFKM(8), PFKP(6), PMM1(2), SORD(2), TPI1(2) 34537095 67 53 65 19 12 13 10 18 14 0 0.445 1.000 1.000 359 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 192 ACTB(5), ACTG1(8), ACTN1(5), ACTN2(10), ACTN4(7), AKT1(2), AKT2(4), AKT3(5), ARHGAP5(12), BAD(1), BCAR1(6), BIRC2(3), BIRC3(4), BRAF(5), CAPN2(8), CAV1(4), CCND1(1), CCND2(2), CCND3(4), COL11A1(8), COL11A2(5), COL1A1(8), COL1A2(10), COL2A1(4), COL3A1(7), COL4A1(10), COL4A2(10), COL4A4(9), COL4A6(10), COL5A1(13), COL5A2(8), COL5A3(12), COL6A1(3), COL6A2(3), COL6A3(15), COL6A6(14), COMP(5), CRK(1), CRKL(1), CTNNB1(2), DIAPH1(5), DOCK1(8), EGF(5), EGFR(5), ELK1(4), ERBB2(21), FARP2(9), FIGF(3), FLNA(17), FLNB(15), FLNC(21), FLT1(5), FN1(9), GSK3B(2), HGF(5), HRAS(2), IBSP(5), IGF1R(7), ILK(3), ITGA1(6), ITGA10(10), ITGA11(7), ITGA2(4), ITGA2B(3), ITGA4(6), ITGA5(4), ITGA6(4), ITGA7(5), ITGA8(10), ITGA9(7), ITGAV(7), ITGB1(5), ITGB3(4), ITGB4(8), ITGB5(2), ITGB6(6), ITGB7(5), ITGB8(4), JUN(3), KDR(8), LAMA1(18), LAMA2(15), LAMA3(15), LAMA4(9), LAMA5(11), LAMB1(12), LAMB2(9), LAMB3(7), LAMB4(15), LAMC1(8), LAMC2(6), LAMC3(3), MAP2K1(5), MAPK1(1), MAPK10(4), MAPK3(1), MAPK8(2), MAPK9(1), MET(10), MYL5(3), MYL7(1), MYL9(1), MYLK(11), MYLK2(5), PAK1(3), PAK2(2), PAK3(4), PAK4(3), PAK6(5), PAK7(4), PARVA(3), PARVG(3), PDGFB(2), PDGFRA(6), PDGFRB(7), PDPK1(2), PGF(5), PIK3CA(351), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R1(15), PIK3R2(4), PIK3R3(3), PIK3R5(5), PIP5K1C(5), PPP1CB(1), PPP1R12A(7), PRKCA(4), PRKCG(3), PTEN(35), PTK2(7), RAF1(4), RAP1A(2), RAP1B(1), RAPGEF1(5), RELN(26), RHOA(6), ROCK1(8), ROCK2(9), SHC1(2), SHC2(2), SHC3(1), SHC4(5), SOS1(5), SOS2(6), SPP1(2), SRC(1), THBS1(8), THBS2(2), THBS3(5), THBS4(4), TLN1(15), TLN2(14), TNC(8), TNN(10), TNR(10), TNXB(16), VAV1(6), VAV2(3), VAV3(7), VCL(6), VEGFA(1), VEGFC(2), VTN(3), VWF(11), ZYX(1) 521983653 1421 624 1100 320 198 384 201 385 246 7 0.000161 1.000 1.000 360 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 246 ACVR1B(8), ACVR1C(3), AKT1(2), AKT2(4), AKT3(5), ARRB1(1), ARRB2(1), ATF2(4), ATF4(3), BDNF(1), BRAF(5), CACNA1A(16), CACNA1B(14), CACNA1C(17), CACNA1D(17), CACNA1E(28), CACNA1F(16), CACNA1G(10), CACNA1H(10), CACNA1I(6), CACNA1S(8), CACNA2D1(7), CACNA2D2(8), CACNA2D3(9), CACNA2D4(4), CACNB1(3), CACNB2(2), CACNB3(4), CACNB4(1), CACNG1(1), CACNG2(1), CACNG3(3), CACNG4(2), CACNG5(2), CACNG6(1), CACNG7(3), CACNG8(1), CASP3(1), CD14(1), CDC25B(3), CHUK(7), CRK(1), CRKL(1), DAXX(2), DUSP1(1), DUSP10(9), DUSP16(6), DUSP2(1), DUSP4(1), DUSP6(1), DUSP7(3), DUSP9(2), EGF(5), EGFR(5), ELK1(4), ELK4(1), FAS(1), FASLG(2), FGF10(2), FGF11(1), FGF12(1), FGF13(4), FGF14(1), FGF16(2), FGF18(4), FGF20(1), FGF21(1), FGF23(3), FGF3(2), FGF6(2), FGF7(3), FGF8(2), FGF9(1), FGFR1(3), FGFR2(11), FGFR3(3), FGFR4(3), FLNA(17), FLNB(15), FLNC(21), GNA12(2), HRAS(2), IKBKB(5), IL1A(1), IL1R1(1), IL1R2(4), JUN(3), KRAS(6), MAP2K1(5), MAP2K2(2), MAP2K3(3), MAP2K4(32), MAP2K5(1), MAP2K6(1), MAP2K7(1), MAP3K1(80), MAP3K10(3), MAP3K12(7), MAP3K13(10), MAP3K2(3), MAP3K3(1), MAP3K4(8), MAP3K5(12), MAP3K6(3), MAP3K7(3), MAP3K8(4), MAP4K1(6), MAP4K2(2), MAP4K3(2), MAP4K4(7), MAPK1(1), MAPK10(4), MAPK13(1), MAPK14(1), MAPK3(1), MAPK7(4), MAPK8(2), MAPK8IP1(1), MAPK8IP2(2), MAPK8IP3(8), MAPK9(1), MAPKAPK2(1), MAPKAPK3(2), MAPT(3), MAX(2), MEF2C(4), MKNK1(2), MKNK2(4), MOS(3), MRAS(2), MYC(1), NF1(29), NFATC2(4), NFATC4(6), NFKB1(5), NFKB2(5), NLK(1), NR4A1(2), NRAS(2), NTRK1(8), NTRK2(5), PAK1(3), PAK2(2), PDGFB(2), PDGFRA(6), PDGFRB(7), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(2), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(1), PPM1A(2), PPM1B(3), PPP3CA(5), PPP3CB(2), PPP3R1(1), PPP5C(3), PRKACA(3), PRKACB(1), PRKACG(3), PRKCA(4), PRKCG(3), PRKX(5), PTPN5(4), PTPN7(2), PTPRR(4), RAF1(4), RAP1A(2), RAP1B(1), RAPGEF2(7), RASA1(2), RASA2(4), RASGRF1(12), RASGRF2(5), RASGRP2(5), RASGRP3(2), RASGRP4(5), RPS6KA1(6), RPS6KA2(5), RPS6KA3(8), RPS6KA4(2), RPS6KA5(4), RPS6KA6(6), SOS1(5), SOS2(6), SRF(1), STK3(2), STK4(3), TAOK1(5), TAOK2(7), TAOK3(5), TGFB1(2), TGFB2(1), TGFB3(1), TGFBR1(4), TGFBR2(4), TNFRSF1A(4), TP53(299), TRAF2(1), TRAF6(4), ZAK(4) 411779430 1251 612 1087 278 219 227 184 234 366 21 0.000888 1.000 1.000 361 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 199 ABI2(3), ACTN1(5), ACTN2(10), ACTN4(7), APC(23), ARAF(5), ARHGEF1(10), ARHGEF12(11), ARHGEF4(6), ARHGEF6(6), ARHGEF7(8), ARPC1A(3), ARPC1B(2), ARPC2(5), ARPC5(1), ARPC5L(3), BAIAP2(2), BCAR1(6), BDKRB1(4), BDKRB2(4), BRAF(5), CD14(1), CFL1(1), CFL2(1), CHRM1(4), CHRM2(6), CHRM3(3), CHRM4(1), CRK(1), CRKL(1), CYFIP1(5), CYFIP2(12), DIAPH1(5), DIAPH2(9), DIAPH3(6), DOCK1(8), EGF(5), EGFR(5), EZR(1), F2(2), F2R(4), FGD1(1), FGD3(4), FGF10(2), FGF11(1), FGF12(1), FGF13(4), FGF14(1), FGF16(2), FGF18(4), FGF20(1), FGF21(1), FGF23(3), FGF3(2), FGF6(2), FGF7(3), FGF8(2), FGF9(1), FGFR1(3), FGFR2(11), FGFR3(3), FGFR4(3), FN1(9), GIT1(3), GNA12(2), GNA13(1), GSN(2), HRAS(2), IQGAP1(7), IQGAP2(8), IQGAP3(10), ITGA1(6), ITGA10(10), ITGA11(7), ITGA2(4), ITGA2B(3), ITGA4(6), ITGA5(4), ITGA6(4), ITGA7(5), ITGA8(10), ITGA9(7), ITGAD(3), ITGAE(2), ITGAL(4), ITGAM(6), ITGAV(7), ITGAX(10), ITGB1(5), ITGB2(7), ITGB3(4), ITGB4(8), ITGB5(2), ITGB6(6), ITGB7(5), ITGB8(4), KRAS(6), LIMK1(7), LIMK2(3), MAP2K1(5), MAP2K2(2), MAPK1(1), MAPK3(1), MOS(3), MRAS(2), MSN(4), MYH10(14), MYH14(13), MYH9(21), MYL5(3), MYL7(1), MYL9(1), MYLK(11), MYLK2(5), NCKAP1(9), NCKAP1L(8), NRAS(2), PAK1(3), PAK2(2), PAK3(4), PAK4(3), PAK6(5), PAK7(4), PDGFB(2), PDGFRA(6), PDGFRB(7), PIK3CA(351), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R1(15), PIK3R2(4), PIK3R3(3), PIK3R5(5), PIP4K2A(2), PIP4K2C(6), PIP5K1A(6), PIP5K1B(2), PIP5K1C(5), PPP1CB(1), PPP1R12A(7), PPP1R12B(4), PTK2(7), RAF1(4), RDX(3), RHOA(6), ROCK1(8), ROCK2(9), SCIN(4), SLC9A1(4), SOS1(5), SOS2(6), SSH1(4), SSH2(5), SSH3(4), TIAM1(7), TIAM2(10), VAV1(6), VAV2(3), VAV3(7), VCL(6), WAS(7), WASF1(6), WASF2(3), WASL(4) 396892782 1164 568 848 278 162 342 139 340 177 4 0.00699 1.000 1.000 362 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 128 ACACA(12), ACACB(10), AKT1(2), AKT2(4), AKT3(5), ARAF(5), BAD(1), BRAF(5), CALM2(1), CALML6(1), CBL(4), CBLB(14), CBLC(7), CRK(1), CRKL(1), ELK1(4), EXOC7(6), FASN(14), FBP1(2), FLOT1(2), FLOT2(2), FOXO1(2), G6PC(2), G6PC2(3), GCK(3), GSK3B(2), GYS1(8), GYS2(1), HRAS(2), IKBKB(5), INPP5D(4), INSR(11), IRS1(4), IRS4(7), KRAS(6), LIPE(5), MAP2K1(5), MAP2K2(2), MAPK1(1), MAPK10(4), MAPK3(1), MAPK8(2), MAPK9(1), MKNK1(2), MKNK2(4), NRAS(2), PCK1(5), PCK2(4), PDE3A(12), PDE3B(4), PDPK1(2), PFKL(1), PFKM(8), PFKP(6), PHKA1(8), PHKA2(13), PHKB(4), PHKG2(1), PIK3CA(351), PIK3CB(8), PIK3CD(6), PIK3CG(5), PIK3R1(15), PIK3R2(4), PIK3R3(3), PIK3R5(5), PKLR(5), PPARGC1A(6), PPP1CB(1), PPP1R3A(13), PPP1R3B(2), PPP1R3C(3), PRKAA1(3), PRKAA2(2), PRKAB1(1), PRKAB2(1), PRKACA(3), PRKACB(1), PRKACG(3), PRKAG1(2), PRKAG2(2), PRKAG3(3), PRKAR1A(4), PRKAR2A(2), PRKAR2B(2), PRKCI(1), PRKCZ(2), PRKX(5), PTPRF(10), PYGB(4), PYGL(3), PYGM(5), RAF1(4), RAPGEF1(5), RHEB(1), RHOQ(2), RPS6(4), RPS6KB1(4), RPS6KB2(5), SH2B2(1), SHC1(2), SHC2(2), SHC3(1), SHC4(5), SLC2A4(1), SOCS2(1), SOCS4(2), SORBS1(7), SOS1(5), SOS2(6), SREBF1(3), TRIP10(4), TSC1(5), TSC2(6) 222145475 822 493 516 158 73 266 85 293 104 1 2.60e-06 1.000 1.000 363 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 141 APC(23), AXIN1(5), AXIN2(5), BTRC(4), CAMK2A(3), CAMK2B(2), CAMK2D(4), CAMK2G(2), CCND1(1), CCND2(2), CCND3(4), CER1(2), CHD8(15), CREBBP(15), CSNK1A1(3), CSNK1A1L(4), CSNK1E(4), CSNK2A1(3), CSNK2A2(1), CTBP1(1), CTBP2(1), CTNNB1(2), CUL1(2), DAAM1(8), DAAM2(5), DKK2(1), DKK4(4), DVL1(2), DVL3(1), EP300(13), FZD1(3), FZD10(2), FZD2(4), FZD3(5), FZD4(1), FZD5(1), FZD6(4), FZD7(3), FZD8(1), FZD9(3), GSK3B(2), JUN(3), LRP5(4), LRP6(6), MAP3K7(3), MAPK10(4), MAPK8(2), MAPK9(1), MYC(1), NFAT5(7), NFATC1(5), NFATC2(4), NFATC3(7), NFATC4(6), NKD1(1), NKD2(2), NLK(1), PLCB1(12), PLCB2(7), PLCB3(2), PLCB4(15), PORCN(4), PPARD(2), PPP2CA(3), PPP2CB(2), PPP2R1A(3), PPP2R2A(1), PPP2R2B(1), PPP2R2C(1), PPP3CA(5), PPP3CB(2), PPP3R1(1), PRICKLE1(2), PRICKLE2(6), PRKACA(3), PRKACB(1), PRKACG(3), PRKCA(4), PRKCG(3), PRKX(5), PSEN1(2), RHOA(6), ROCK1(8), ROCK2(9), RUVBL1(2), SENP2(1), SFRP1(3), SFRP2(2), SFRP4(2), SIAH1(3), SKP1(1), SMAD2(7), SMAD3(4), SMAD4(7), TBL1X(5), TBL1XR1(10), TCF7(3), TCF7L1(2), TCF7L2(3), TP53(299), VANGL1(2), VANGL2(8), WIF1(3), WNT10B(1), WNT11(1), WNT16(2), WNT2(1), WNT2B(4), WNT3(1), WNT3A(1), WNT4(1), WNT5B(4), WNT6(1), WNT7A(6), WNT7B(1), WNT8B(2), WNT9A(1) 221131772 735 445 592 149 139 128 102 146 214 6 0.00116 1.000 1.000 364 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 168 ADCY1(5), ADCY2(3), ADCY3(5), ADCY4(4), ADCY7(11), ADCY8(6), ADCY9(14), ADORA2A(3), ADRA1A(6), ADRA1B(1), ADRB2(2), ADRB3(1), AGTR1(4), ATP2A1(11), ATP2A2(3), ATP2A3(1), ATP2B1(14), ATP2B2(9), ATP2B3(9), ATP2B4(10), AVPR1B(5), BDKRB1(4), BDKRB2(4), BST1(2), CACNA1A(16), CACNA1B(14), CACNA1C(17), CACNA1D(17), CACNA1E(28), CACNA1F(16), CACNA1G(10), CACNA1H(10), CACNA1I(6), CACNA1S(8), CALM2(1), CALML6(1), CAMK2A(3), CAMK2B(2), CAMK2D(4), CAMK2G(2), CAMK4(5), CCKAR(3), CCKBR(2), CD38(3), CHRM1(4), CHRM2(6), CHRM3(3), CHRNA7(1), CYSLTR1(5), CYSLTR2(1), DRD1(1), EDNRA(3), EDNRB(2), EGFR(5), ERBB2(21), ERBB3(17), ERBB4(13), F2R(4), GNA11(3), GNA14(1), GNAQ(1), GNAS(11), GRIN1(3), GRIN2A(16), GRIN2C(5), GRIN2D(5), GRM1(9), GRM5(4), GRPR(3), HRH1(4), HRH2(4), HTR2A(5), HTR2C(5), HTR5A(4), ITPKA(1), ITPKB(8), ITPR1(15), ITPR2(18), ITPR3(14), LHCGR(10), MYLK(11), MYLK2(5), NOS1(13), NOS3(3), OXTR(1), P2RX2(3), P2RX3(1), P2RX4(2), P2RX5(4), P2RX7(3), PDE1A(5), PDE1B(5), PDE1C(5), PDGFRA(6), PDGFRB(7), PHKA1(8), PHKA2(13), PHKB(4), PHKG2(1), PLCB1(12), PLCB2(7), PLCB3(2), PLCB4(15), PLCD1(3), PLCD3(2), PLCD4(6), PLCE1(15), PLCG1(8), PLCG2(8), PLCZ1(10), PLN(1), PPID(3), PPP3CA(5), PPP3CB(2), PPP3R1(1), PRKACA(3), PRKACB(1), PRKACG(3), PRKCA(4), PRKCG(3), PRKX(5), PTAFR(1), PTGER3(2), PTGFR(1), PTK2B(6), RYR1(30), RYR2(53), RYR3(43), SLC25A4(3), SLC25A5(2), SLC25A6(2), SLC8A1(10), SLC8A2(3), SLC8A3(4), SPHK1(1), SPHK2(2), TACR1(2), TACR2(4), TACR3(2), TNNC2(2), TRPC1(9), VDAC1(1), VDAC2(3), VDAC3(1) 389209104 946 423 932 309 211 223 157 214 140 1 0.579 1.000 1.000 365 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 135 ACTB(5), ACTG1(8), COL11A1(8), COL11A2(5), COL17A1(9), COL1A1(8), COL1A2(10), COL2A1(4), COL3A1(7), COL4A1(10), COL4A2(10), COL4A4(9), COL4A6(10), COL5A1(13), COL5A2(8), COL5A3(12), COL6A1(3), COL6A2(3), COL6A3(15), COL6A6(14), COMP(5), DSC1(3), DSC2(12), DSC3(3), DSG1(4), DSG2(4), DSG3(8), DSG4(5), FN1(9), GJA1(4), GJA10(3), GJA4(1), GJA5(4), GJA8(2), GJA9(1), GJB1(1), GJB2(1), GJB3(3), GJB4(1), GJB5(2), GJB6(1), GJB7(1), GJC1(1), GJD2(2), GJD4(2), IBSP(5), ITGA6(4), ITGB4(8), KRT1(6), KRT10(1), KRT12(1), KRT13(2), KRT14(4), KRT15(1), KRT16(1), KRT17(8), KRT18(3), KRT19(6), KRT2(5), KRT20(2), KRT23(3), KRT24(2), KRT25(5), KRT27(1), KRT28(5), KRT3(4), KRT31(2), KRT32(4), KRT33A(1), KRT33B(1), KRT34(3), KRT35(2), KRT36(2), KRT37(1), KRT38(1), KRT39(1), KRT4(3), KRT40(1), KRT5(3), KRT6A(1), KRT6B(3), KRT6C(1), KRT7(1), KRT71(1), KRT72(3), KRT73(5), KRT74(1), KRT75(4), KRT76(2), KRT78(3), KRT79(2), KRT8(2), KRT81(3), KRT82(5), KRT83(4), KRT84(3), KRT85(3), KRT86(4), KRT9(3), LAMA1(18), LAMA2(15), LAMA3(15), LAMA4(9), LAMA5(11), LAMB1(12), LAMB2(9), LAMB3(7), LAMB4(15), LAMC1(8), LAMC2(6), LAMC3(3), LMNA(4), LMNB1(2), LMNB2(3), NES(14), RELN(26), SPP1(2), THBS1(8), THBS2(2), THBS3(5), THBS4(4), TNC(8), TNN(10), TNR(10), TNXB(16), VIM(2), VTN(3), VWF(11) 348150035 668 347 661 222 130 155 146 116 119 2 0.951 1.000 1.000 366 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 129 ACTB(5), ACTG1(8), ACTN1(5), ACTN2(10), ACTN4(7), AKT1(2), AKT2(4), AKT3(5), AMOTL1(6), ASH1L(19), CASK(10), CDK4(1), CGN(7), CLDN1(1), CLDN10(2), CLDN11(1), CLDN14(1), CLDN15(1), CLDN16(2), CLDN17(2), CLDN18(2), CLDN19(2), CLDN2(1), CLDN22(2), CLDN4(1), CLDN6(6), CRB3(1), CSNK2A1(3), CSNK2A2(1), CTNNA1(7), CTNNA2(14), CTNNA3(6), CTNNB1(2), CTTN(2), EPB41(5), EPB41L1(6), EPB41L2(7), EPB41L3(10), EXOC3(4), EXOC4(9), F11R(4), GNAI1(2), GNAI2(2), GNAI3(1), HCLS1(2), HRAS(2), IGSF5(3), INADL(11), KRAS(6), LLGL1(5), LLGL2(2), MAGI1(15), MAGI2(9), MAGI3(7), MLLT4(19), MPDZ(13), MPP5(3), MRAS(2), MYH1(13), MYH10(14), MYH11(12), MYH13(12), MYH14(13), MYH15(16), MYH2(10), MYH3(5), MYH4(8), MYH6(11), MYH7(20), MYH7B(11), MYH8(15), MYH9(21), MYL5(3), MYL7(1), MYL9(1), NRAS(2), OCLN(3), PARD3(8), PARD6A(1), PARD6B(2), PPM1J(2), PPP2CA(3), PPP2CB(2), PPP2R1A(3), PPP2R2A(1), PPP2R2B(1), PPP2R2C(1), PPP2R3A(4), PPP2R3B(3), PPP2R4(4), PRKCA(4), PRKCD(5), PRKCE(8), PRKCG(3), PRKCH(3), PRKCI(1), PRKCQ(8), PRKCZ(2), PTEN(35), RAB13(3), RAB3B(1), RHOA(6), SPTAN1(12), SRC(1), SYMPK(8), TJAP1(2), TJP1(8), TJP2(4), TJP3(4), VAPA(2), YES1(2), ZAK(4) 278649844 650 341 634 177 120 160 95 123 147 5 0.626 1.000 1.000 367 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(5), ADCY2(3), ADCY3(5), ADCY4(4), ADCY5(10), ADCY6(2), ADCY7(11), ADCY8(6), ADCY9(14), ADRA1A(6), ADRA1B(1), ADRB2(2), ADRB3(1), ANXA6(5), ARRB1(1), ARRB2(1), ATP1A4(13), ATP1B1(3), ATP1B3(1), ATP2A2(3), ATP2A3(1), ATP2B1(14), ATP2B2(9), ATP2B3(9), CACNA1A(16), CACNA1B(14), CACNA1C(17), CACNA1D(17), CACNA1E(28), CACNA1S(8), CACNB1(3), CACNB3(4), CALM2(1), CALR(1), CAMK1(1), CAMK2A(3), CAMK2B(2), CAMK2D(4), CAMK2G(2), CAMK4(5), CASQ1(2), CASQ2(6), CHRM1(4), CHRM2(6), CHRM3(3), CHRM4(1), GJA1(4), GJA4(1), GJA5(4), GJB1(1), GJB2(1), GJB3(3), GJB4(1), GJB5(2), GJB6(1), GNA11(3), GNAI2(2), GNAI3(1), GNAO1(2), GNAQ(1), GNAZ(3), GNB1(2), GNB2(1), GNB3(3), GNB5(2), GRK4(1), GRK5(2), GRK6(3), ITPR1(15), ITPR2(18), ITPR3(14), KCNB1(7), KCNJ3(2), KCNJ5(1), MIB1(7), NME7(4), PEA15(1), PKIA(1), PKIG(2), PLCB3(2), PLN(1), PRKACA(3), PRKACB(1), PRKAR1A(4), PRKAR2A(2), PRKAR2B(2), PRKCA(4), PRKCD(5), PRKCE(8), PRKCG(3), PRKCH(3), PRKCQ(8), PRKCZ(2), PRKD1(5), RGS1(2), RGS10(1), RGS11(1), RGS14(4), RGS16(3), RGS17(3), RGS20(4), RGS3(7), RGS4(4), RGS5(2), RGS6(4), RGS7(10), RGS9(6), RYR1(30), RYR2(53), RYR3(43), SFN(1), SLC8A1(10), SLC8A3(4), USP5(7), YWHAB(2) 274371255 648 336 645 232 150 150 115 130 101 2 0.944 1.000 1.000 368 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 233 ADCYAP1R1(4), ADORA1(3), ADORA2A(3), ADORA3(1), ADRA1A(6), ADRA1B(1), ADRA2B(4), ADRA2C(2), ADRB2(2), ADRB3(1), AGTR1(4), AGTR2(2), AVPR1B(5), AVPR2(3), BDKRB1(4), BDKRB2(4), BRS3(4), C3AR1(3), C5AR1(3), CALCR(2), CALCRL(3), CCKAR(3), CCKBR(2), CHRM1(4), CHRM2(6), CHRM3(3), CHRM4(1), CNR1(1), CNR2(1), CRHR1(3), CRHR2(1), CTSG(1), CYSLTR1(5), CYSLTR2(1), DRD1(1), DRD2(3), DRD3(1), DRD5(4), EDNRA(3), EDNRB(2), F2(2), F2R(4), F2RL1(1), F2RL2(2), FPR1(3), FSHR(9), GABBR1(4), GABBR2(4), GABRA1(4), GABRA2(3), GABRA3(6), GABRA4(7), GABRA5(4), GABRA6(5), GABRB1(3), GABRB2(5), GABRB3(1), GABRD(1), GABRE(2), GABRG1(7), GABRG2(3), GABRG3(4), GABRP(1), GABRQ(5), GABRR1(2), GALR1(1), GALR2(2), GALR3(1), GH2(2), GHR(5), GHRHR(4), GHSR(2), GIPR(1), GLP1R(2), GLP2R(3), GLRA2(2), GLRA3(2), GLRB(1), GPR156(4), GPR35(1), GPR50(4), GPR63(3), GPR83(5), GRIA1(9), GRIA2(3), GRIA3(16), GRIA4(7), GRID1(12), GRID2(10), GRIK1(11), GRIK2(12), GRIK3(6), GRIK4(3), GRIK5(5), GRIN1(3), GRIN2A(16), GRIN2B(11), GRIN2C(5), GRIN2D(5), GRIN3A(10), GRIN3B(3), GRM1(9), GRM2(3), GRM3(9), GRM4(3), GRM5(4), GRM6(2), GRM7(2), GRM8(5), GRPR(3), GZMA(3), HCRTR1(2), HCRTR2(2), HRH1(4), HRH2(4), HRH3(2), HRH4(2), HTR1A(4), HTR1B(3), HTR1D(4), HTR1E(4), HTR1F(4), HTR2A(5), HTR2C(5), HTR5A(4), LEP(1), LEPR(7), LHCGR(10), MAS1(2), MC1R(1), MC2R(2), MC3R(3), MC4R(2), MCHR1(1), MCHR2(3), MLNR(1), NMBR(3), NMUR1(3), NMUR2(3), NPBWR1(3), NPFFR2(7), NPY1R(5), NPY2R(3), NR3C1(3), NTSR2(2), OPRD1(3), OPRK1(2), OPRL1(3), OPRM1(3), OXTR(1), P2RX2(3), P2RX3(1), P2RX4(2), P2RX5(4), P2RX7(3), P2RY1(4), P2RY10(7), P2RY11(1), P2RY13(4), P2RY2(1), P2RY4(2), P2RY6(1), P2RY8(1), PARD3(8), PRLHR(2), PRLR(4), PRSS3(3), PTAFR(1), PTGDR(2), PTGER2(3), PTGER3(2), PTGER4(1), PTGFR(1), PTH2R(2), RXFP1(4), RXFP2(3), SSTR2(1), SSTR3(2), SSTR4(1), SSTR5(1), TAAR1(3), TAAR2(4), TAAR5(4), TAAR6(2), TAAR8(1), TACR1(2), TACR2(4), TACR3(2), THRA(3), THRB(2), TRPV1(1), TSHR(7), VIPR1(1), VIPR2(3) 305382822 677 331 676 233 148 162 130 156 79 2 0.455 1.000 1.000 369 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 124 ALCAM(5), CADM1(2), CADM3(2), CD2(4), CD22(5), CD226(2), CD274(2), CD276(1), CD28(2), CD34(2), CD4(4), CD40(2), CD40LG(1), CD58(2), CD86(4), CD8A(3), CD8B(3), CD99(4), CDH1(109), CDH15(2), CDH2(2), CDH3(1), CDH4(6), CDH5(1), CLDN1(1), CLDN10(2), CLDN11(1), CLDN14(1), CLDN15(1), CLDN16(2), CLDN17(2), CLDN18(2), CLDN19(2), CLDN2(1), CLDN22(2), CLDN4(1), CLDN6(6), CNTN1(12), CNTN2(8), CNTNAP1(11), CNTNAP2(11), CTLA4(1), ESAM(3), F11R(4), GLG1(6), HLA-A(3), HLA-B(3), HLA-C(6), HLA-DMB(3), HLA-DPB1(1), HLA-DQA2(1), HLA-DQB1(3), HLA-DRB1(10), HLA-DRB5(5), HLA-F(3), HLA-G(1), ICAM1(2), ICAM2(1), ICAM3(3), ICOS(3), ICOSLG(6), ITGA4(6), ITGA6(4), ITGA8(10), ITGA9(7), ITGAL(4), ITGAM(6), ITGAV(7), ITGB1(5), ITGB2(7), ITGB7(5), ITGB8(4), L1CAM(10), MADCAM1(1), MAG(3), MPZ(1), MPZL1(3), NCAM1(7), NCAM2(4), NEGR1(2), NEO1(6), NFASC(10), NLGN1(7), NLGN2(7), NLGN3(11), NRCAM(12), NRXN1(11), NRXN2(12), NRXN3(10), OCLN(3), PDCD1(2), PTPRC(8), PTPRF(10), PTPRM(7), PVR(3), PVRL1(3), PVRL2(5), PVRL3(4), SDC1(3), SDC2(2), SDC3(2), SDC4(2), SELE(2), SELL(6), SELP(10), SELPLG(2), SIGLEC1(6), SPN(2), VCAM1(7), VCAN(22) 201489636 598 331 573 163 82 137 95 102 180 2 0.395 1.000 1.000 370 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(7), CD36(4), CD44(3), CD47(2), COL11A1(8), COL11A2(5), COL1A1(8), COL1A2(10), COL2A1(4), COL3A1(7), COL4A1(10), COL4A2(10), COL4A4(9), COL4A6(10), COL5A1(13), COL5A2(8), COL5A3(12), COL6A1(3), COL6A2(3), COL6A3(15), COL6A6(14), DAG1(2), FN1(9), FNDC1(10), FNDC3A(5), GP5(3), GP6(1), HMMR(4), HSPG2(14), IBSP(5), ITGA1(6), ITGA10(10), ITGA11(7), ITGA2(4), ITGA2B(3), ITGA4(6), ITGA5(4), ITGA6(4), ITGA7(5), ITGA8(10), ITGA9(7), ITGAV(7), ITGB1(5), ITGB3(4), ITGB4(8), ITGB5(2), ITGB6(6), ITGB7(5), ITGB8(4), LAMA1(18), LAMA2(15), LAMA3(15), LAMA4(9), LAMA5(11), LAMB1(12), LAMB2(9), LAMB3(7), LAMB4(15), LAMC1(8), LAMC2(6), LAMC3(3), RELN(26), SDC1(3), SDC2(2), SDC3(2), SDC4(2), SPP1(2), SV2A(4), SV2B(4), SV2C(1), THBS1(8), THBS2(2), THBS3(5), THBS4(4), TNC(8), TNN(10), TNR(10), TNXB(16), VTN(3), VWF(11) 313136894 576 306 568 201 103 135 116 105 114 3 0.989 1.000 1.000 371 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY1(5), ADCY2(3), ADCY3(5), ADCY4(4), ADCY5(10), ADCY6(2), ADCY7(11), ADCY8(6), ADCY9(14), ATF4(3), CACNA1C(17), CACNA1D(17), CACNA1F(16), CACNA1S(8), CALM2(1), CALML6(1), CAMK2A(3), CAMK2B(2), CAMK2D(4), CAMK2G(2), EGFR(5), ELK1(4), GNA11(3), GNAQ(1), GNAS(11), HRAS(2), ITPR1(15), ITPR2(18), ITPR3(14), JUN(3), KRAS(6), MAP2K1(5), MAP2K2(2), MAP2K3(3), MAP2K4(32), MAP2K6(1), MAP2K7(1), MAP3K1(80), MAP3K2(3), MAP3K3(1), MAP3K4(8), MAPK1(1), MAPK10(4), MAPK13(1), MAPK14(1), MAPK3(1), MAPK7(4), MAPK8(2), MAPK9(1), MMP14(4), MMP2(3), NRAS(2), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(2), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(1), PLCB1(12), PLCB2(7), PLCB3(2), PLCB4(15), PLD1(7), PLD2(2), PRKACA(3), PRKACB(1), PRKACG(3), PRKCA(4), PRKCD(5), PRKX(5), PTK2B(6), RAF1(4), SOS1(5), SOS2(6), SRC(1) 184706283 483 305 464 128 80 100 67 84 134 18 0.597 1.000 1.000 372 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 75 ACTB(5), ACTG1(8), ACTN1(5), ACTN2(10), ACTN4(7), ACVR1B(8), ACVR1C(3), BAIAP2(2), CDH1(109), CREBBP(15), CSNK2A1(3), CSNK2A2(1), CTNNA1(7), CTNNA2(14), CTNNA3(6), CTNNB1(2), CTNND1(5), EGFR(5), EP300(13), ERBB2(21), FARP2(9), FER(5), FGFR1(3), IGF1R(7), INSR(11), IQGAP1(7), LMO7(5), MAP3K7(3), MAPK1(1), MAPK3(1), MET(10), MLLT4(19), NLK(1), PARD3(8), PTPRB(11), PTPRF(10), PTPRJ(7), PTPRM(7), PVRL1(3), PVRL2(5), PVRL3(4), PVRL4(2), RHOA(6), SMAD2(7), SMAD3(4), SMAD4(7), SNAI1(2), SORBS1(7), SRC(1), SSX2IP(4), TCF7(3), TCF7L1(2), TCF7L2(3), TGFBR1(4), TGFBR2(4), TJP1(8), VCL(6), WAS(7), WASF1(6), WASF2(3), WASF3(5), WASL(4), YES1(2) 172808679 483 301 451 106 74 111 56 70 172 0 0.109 1.000 1.000 373 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 136 ACTA1(3), ACTA2(3), ADCY1(5), ADCY2(3), ADCY3(5), ADCY4(4), ADCY5(10), ADCY6(2), ADCY7(11), ADCY8(6), ADCY9(14), ARRB1(1), ARRB2(1), ATF1(3), ATF2(4), ATF3(2), ATF4(3), ATF5(1), ATP2A2(3), ATP2A3(1), CACNB3(4), CALCA(1), CALM2(1), CAMK2A(3), CAMK2B(2), CAMK2D(4), CAMK2G(2), CNN1(3), CNN2(1), CORIN(6), CRHR1(3), DGKZ(1), ETS2(7), GABPA(1), GABPB2(2), GBA2(4), GJA1(4), GNAQ(1), GNB1(2), GNB2(1), GNB3(3), GNB5(2), GRK4(1), GRK5(2), GRK6(3), GSTO1(1), GUCY1A3(2), IGFBP2(1), IGFBP4(1), IGFBP6(1), IL6(1), ITPR1(15), ITPR2(18), ITPR3(14), JUN(3), MIB1(7), MYLK2(5), NFKB1(5), NOS1(13), NOS3(3), OXTR(1), PDE4B(10), PDE4D(8), PKIA(1), PKIG(2), PLCB3(2), PLCD1(3), PLCG1(8), PLCG2(8), PRKACA(3), PRKACB(1), PRKAR1A(4), PRKAR2A(2), PRKAR2B(2), PRKCA(4), PRKCD(5), PRKCE(8), PRKCH(3), PRKCQ(8), PRKCZ(2), PRKD1(5), RAMP3(1), RGS1(2), RGS10(1), RGS11(1), RGS14(4), RGS16(3), RGS17(3), RGS20(4), RGS3(7), RGS4(4), RGS5(2), RGS6(4), RGS7(10), RGS9(6), RYR1(30), RYR2(53), RYR3(43), SFN(1), SLC8A1(10), SP1(6), TNXB(16), USP5(7), YWHAB(2) 244957224 549 297 546 201 127 131 91 105 92 3 0.987 1.000 1.000 374 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 126 ABL1(6), ABLIM1(2), ABLIM2(3), ABLIM3(6), ARHGEF12(11), CDK5(2), CFL1(1), CFL2(1), CXCR4(3), DCC(14), DPYSL2(2), DPYSL5(4), EFNA1(2), EFNA3(3), EFNA4(1), EFNA5(1), EFNB1(1), EFNB2(2), EFNB3(3), EPHA1(8), EPHA2(3), EPHA3(7), EPHA4(5), EPHA5(7), EPHA6(6), EPHA7(8), EPHA8(2), EPHB1(12), EPHB2(5), EPHB3(5), EPHB4(4), EPHB6(5), FES(4), GNAI1(2), GNAI2(2), GNAI3(1), GSK3B(2), HRAS(2), ITGB1(5), KRAS(6), L1CAM(10), LIMK1(7), LIMK2(3), LRRC4C(4), MAPK1(1), MAPK3(1), MET(10), NCK1(2), NCK2(1), NFAT5(7), NFATC1(5), NFATC2(4), NFATC3(7), NFATC4(6), NGEF(3), NRAS(2), NRP1(7), NTN1(1), NTN4(1), NTNG1(2), PAK1(3), PAK2(2), PAK3(4), PAK4(3), PAK6(5), PAK7(4), PLXNA1(12), PLXNA2(12), PLXNA3(9), PLXNB1(4), PLXNB2(8), PLXNB3(5), PLXNC1(6), PPP3CA(5), PPP3CB(2), PPP3R1(1), PTK2(7), RASA1(2), RGS3(7), RHOA(6), RND1(2), ROBO1(13), ROBO2(11), ROBO3(6), ROCK1(8), ROCK2(9), SEMA3A(5), SEMA3C(6), SEMA3D(4), SEMA3E(2), SEMA3F(2), SEMA3G(2), SEMA4A(4), SEMA4C(2), SEMA4D(8), SEMA4F(9), SEMA4G(6), SEMA5A(12), SEMA5B(5), SEMA6A(9), SEMA6C(5), SEMA6D(4), SEMA7A(2), SLIT1(2), SLIT2(11), SLIT3(5), SRGAP1(10), SRGAP2(9), SRGAP3(4), UNC5A(1), UNC5B(5), UNC5C(3), UNC5D(14) 272229525 560 291 553 185 104 140 118 98 100 0 0.891 1.000 1.000 375 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 249 ACVR1B(8), ACVR2A(8), ACVR2B(1), AMHR2(3), BMP2(3), BMPR1A(1), BMPR1B(6), BMPR2(8), CCL11(1), CCL13(2), CCL15(1), CCL19(1), CCL2(1), CCL20(1), CCL21(1), CCL23(1), CCL26(1), CCL28(1), CCR1(3), CCR2(4), CCR3(2), CCR4(1), CCR5(1), CCR6(1), CCR7(4), CCR8(1), CCR9(1), CD40(2), CD40LG(1), CD70(1), CLCF1(1), CNTFR(2), CRLF2(1), CSF1(5), CSF1R(3), CSF2RA(2), CSF2RB(4), CSF3(2), CSF3R(6), CX3CL1(2), CX3CR1(2), CXCL10(1), CXCL2(1), CXCL6(3), CXCR3(6), CXCR4(3), CXCR6(1), EDA(2), EDA2R(3), EDAR(4), EGF(5), EGFR(5), EPO(1), EPOR(4), FAS(1), FASLG(2), FLT1(5), FLT3(4), FLT3LG(1), FLT4(3), GDF5(2), GH2(2), GHR(5), HGF(5), IFNA1(1), IFNA10(3), IFNA13(3), IFNA14(3), IFNA16(2), IFNA17(3), IFNA2(3), IFNA21(4), IFNA4(2), IFNA6(1), IFNA7(2), IFNA8(2), IFNAR1(2), IFNAR2(1), IFNG(2), IFNGR1(2), IFNK(2), IL10RA(1), IL10RB(3), IL11(1), IL11RA(5), IL12B(2), IL12RB1(7), IL12RB2(4), IL13RA1(1), IL15(3), IL17A(1), IL17B(2), IL17RA(2), IL17RB(3), IL18(2), IL18R1(4), IL18RAP(1), IL19(1), IL1A(1), IL1R1(1), IL1R2(4), IL1RAP(10), IL20(1), IL20RA(1), IL21(2), IL21R(2), IL22(2), IL22RA1(4), IL22RA2(3), IL23A(2), IL23R(4), IL24(3), IL25(2), IL2RA(2), IL2RB(3), IL2RG(2), IL3(1), IL3RA(3), IL4(1), IL4R(6), IL5RA(4), IL6(1), IL6R(4), IL6ST(9), IL7(1), IL7R(4), IL9R(2), INHBA(4), INHBB(1), INHBC(1), INHBE(3), KDR(8), KIT(8), KITLG(3), LEP(1), LEPR(7), LIF(1), LIFR(9), LTA(2), LTBR(1), MET(10), MPL(2), NGFR(1), OSM(1), OSMR(5), PDGFB(2), PDGFRA(6), PDGFRB(7), PF4(1), PLEKHO2(1), PPBP(1), PRLR(4), RELT(1), TGFB1(2), TGFB2(1), TGFB3(1), TGFBR1(4), TGFBR2(4), TNFRSF10A(1), TNFRSF10B(1), TNFRSF10D(1), TNFRSF11A(2), TNFRSF11B(3), TNFRSF13B(2), TNFRSF19(2), TNFRSF1A(4), TNFRSF1B(2), TNFRSF21(2), TNFRSF25(2), TNFRSF6B(1), TNFRSF8(4), TNFRSF9(2), TNFSF12(3), TNFSF13(3), TNFSF13B(1), TNFSF14(1), TNFSF15(1), TNFSF18(1), TNFSF4(3), TNFSF8(2), TNFSF9(1), TPO(7), TSLP(1), VEGFA(1), VEGFC(2), XCL1(2), XCR1(3) 251934464 500 279 495 129 69 130 99 107 93 2 0.0928 1.000 1.000 376 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(3), ACTA2(3), ACTN2(10), ACTN4(7), DMD(48), MYBPC1(4), MYBPC2(11), MYBPC3(3), MYH3(5), MYH6(11), MYH7(20), MYH8(15), MYL1(1), MYL9(1), MYOM1(7), NEB(38), TMOD1(1), TNNC2(2), TNNI3(5), TNNT1(2), TNNT3(3), TPM1(4), TPM2(2), TPM3(2), TTN(250), VIM(2) 206211095 460 265 458 123 77 147 66 96 70 4 0.534 1.000 1.000 377 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 83 ATF2(4), BRAF(5), CHUK(7), CREB1(1), DAXX(2), ELK1(4), HRAS(2), IKBKB(5), JUN(3), MAP2K1(5), MAP2K2(2), MAP2K3(3), MAP2K4(32), MAP2K5(1), MAP2K6(1), MAP2K7(1), MAP3K1(80), MAP3K10(3), MAP3K12(7), MAP3K13(10), MAP3K2(3), MAP3K3(1), MAP3K4(8), MAP3K5(12), MAP3K6(3), MAP3K7(3), MAP3K8(4), MAP3K9(5), MAP4K1(6), MAP4K2(2), MAP4K3(2), MAP4K4(7), MAP4K5(1), MAPK1(1), MAPK10(4), MAPK13(1), MAPK14(1), MAPK3(1), MAPK4(6), MAPK6(6), MAPK7(4), MAPK8(2), MAPK9(1), MAPKAPK2(1), MAPKAPK3(2), MAX(2), MEF2A(6), MEF2C(4), MEF2D(3), MKNK1(2), MKNK2(4), MYC(1), NFKB1(5), NFKBIA(3), PAK1(3), PAK2(2), RAF1(4), RELA(3), RIPK1(5), RPS6KA1(6), RPS6KA2(5), RPS6KA3(8), RPS6KA4(2), RPS6KA5(4), RPS6KB1(4), RPS6KB2(5), SHC1(2), SP1(6), STAT1(4), TGFB1(2), TGFB2(1), TGFB3(1), TGFBR1(4), TRAF2(1) 136838333 367 251 351 65 54 80 37 57 121 18 0.0201 1.000 1.000 378 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 140 ADA(2), ADCY1(5), ADCY2(3), ADCY3(5), ADCY4(4), ADCY5(10), ADCY6(2), ADCY7(11), ADCY8(6), ADCY9(14), ADK(2), ADSL(3), ADSS(3), ADSSL1(1), AK1(1), AK2(1), AK5(4), AK7(4), ALLC(4), AMPD1(10), AMPD2(1), AMPD3(7), ATIC(3), CANT1(2), DCK(1), DGUOK(4), ENPP1(7), ENPP3(5), ENTPD1(4), ENTPD2(3), ENTPD3(1), ENTPD4(4), ENTPD5(5), ENTPD6(3), ENTPD8(1), FHIT(2), GART(3), GDA(2), GMPR2(1), GMPS(5), GUCY1A2(6), GUCY1A3(2), GUCY1B3(2), GUCY2C(9), GUCY2D(4), GUCY2F(7), GUK1(1), IMPDH1(2), ITPA(1), NME6(1), NME7(4), NPR1(4), NPR2(10), NT5C1A(2), NT5C1B(4), NT5C2(2), NT5E(4), NUDT2(1), NUDT5(1), NUDT9(2), PAICS(3), PAPSS1(2), PAPSS2(2), PDE10A(8), PDE11A(5), PDE1A(5), PDE1C(5), PDE2A(4), PDE3B(4), PDE4A(1), PDE4B(10), PDE4C(5), PDE4D(8), PDE5A(6), PDE7B(1), PDE8A(1), PDE8B(1), PDE9A(5), PFAS(6), PKLR(5), PNPT1(5), POLA1(15), POLA2(5), POLD1(5), POLD2(1), POLE(10), POLE2(2), POLE3(1), POLR1A(10), POLR1B(4), POLR1C(2), POLR1D(4), POLR2A(6), POLR2B(5), POLR2C(1), POLR2D(1), POLR2F(3), POLR2G(1), POLR2H(1), POLR2J(1), POLR3A(5), POLR3B(2), POLR3GL(4), POLR3H(1), POLR3K(1), PPAT(5), PRIM1(1), PRPS2(1), PRUNE(4), RFC5(1), RRM1(4), RRM2(1), RRM2B(1), XDH(9) 233113832 438 241 434 152 82 117 82 83 73 1 0.972 1.000 1.000 379 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 90 ACTB(5), BAD(1), CABIN1(8), CALM2(1), CAMK2B(2), CAMK4(5), CD3E(3), CD3G(3), CD69(2), CDKN1A(1), CNR1(1), CREBBP(15), CSNK2A1(3), CTLA4(1), EGR2(3), EGR3(4), EP300(13), FCER1A(4), FCGR3A(3), GATA3(100), GATA4(2), GSK3A(5), GSK3B(2), HRAS(2), ICOS(3), IFNA1(1), IFNG(2), IL2RA(2), IL3(1), IL4(1), IL6(1), ITK(7), KPNA5(5), MAP2K7(1), MAPK14(1), MAPK8(2), MAPK9(1), MEF2A(6), MEF2D(3), MYF5(4), NCK2(1), NFAT5(7), NFATC1(5), NFATC2(4), NFATC3(7), NFATC4(6), NFKB2(5), NFKBIB(1), NFKBIE(2), NUP214(11), OPRD1(3), P2RX7(3), PAK1(3), PPP3CB(2), PPP3R1(1), PTPRC(8), RELA(3), RPL13A(4), SFN(1), SLA(1), SP1(6), SP3(7), TGFB1(2), TRAF2(1), TRPV6(5), VAV1(6), VAV2(3), VAV3(7), XPO5(7) 127252361 352 240 307 71 34 62 46 60 149 1 0.455 1.000 1.000 380 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 91 ADCY1(5), ADCY2(3), ADCY3(5), ADCY4(4), ADCY5(10), ADCY6(2), ADCY7(11), ADCY8(6), ADCY9(14), DRD1(1), DRD2(3), EGF(5), EGFR(5), GJA1(4), GJD2(2), GNA11(3), GNAI1(2), GNAI2(2), GNAI3(1), GNAQ(1), GNAS(11), GRM1(9), GRM5(4), GUCY1A2(6), GUCY1A3(2), GUCY1B3(2), GUCY2C(9), GUCY2D(4), GUCY2F(7), HRAS(2), HTR2A(5), HTR2C(5), ITPR1(15), ITPR2(18), ITPR3(14), KRAS(6), MAP2K1(5), MAP2K2(2), MAP2K5(1), MAP3K2(3), MAPK1(1), MAPK3(1), MAPK7(4), NPR1(4), NPR2(10), NRAS(2), PDGFB(2), PDGFRA(6), PDGFRB(7), PLCB1(12), PLCB2(7), PLCB3(2), PLCB4(15), PRKACA(3), PRKACB(1), PRKACG(3), PRKCA(4), PRKCG(3), PRKG1(4), PRKG2(7), PRKX(5), RAF1(4), SOS1(5), SOS2(6), SRC(1), TJP1(8), TUBA1A(2), TUBA1B(2), TUBA1C(4), TUBA3C(4), TUBA3D(3), TUBA3E(3), TUBA4A(1), TUBA8(1), TUBAL3(2), TUBB(2), TUBB1(4), TUBB2B(3), TUBB3(2), TUBB6(2), TUBB8(4) 186760297 385 220 378 123 87 97 60 81 60 0 0.668 1.000 1.000 381 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 ARAF(5), BRAF(5), CACNA1A(16), CRHR1(3), GNA11(3), GNA12(2), GNA13(1), GNAI1(2), GNAI2(2), GNAI3(1), GNAO1(2), GNAQ(1), GNAS(11), GNAZ(3), GRIA1(9), GRIA2(3), GRIA3(16), GRID2(10), GRM1(9), GRM5(4), GUCY1A2(6), GUCY1A3(2), GUCY1B3(2), GUCY2C(9), GUCY2D(4), GUCY2F(7), HRAS(2), IGF1R(7), ITPR1(15), ITPR2(18), ITPR3(14), KRAS(6), LYN(6), MAP2K1(5), MAP2K2(2), MAPK1(1), MAPK3(1), NOS1(13), NOS3(3), NPR1(4), NPR2(10), NRAS(2), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(2), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(1), PLCB1(12), PLCB2(7), PLCB3(2), PLCB4(15), PPP2CA(3), PPP2CB(2), PPP2R1A(3), PPP2R2A(1), PPP2R2B(1), PPP2R2C(1), PRKCA(4), PRKCG(3), PRKG1(4), PRKG2(7), RAF1(4), RYR1(30) 158130385 365 216 360 93 78 94 68 67 57 1 0.0621 1.000 1.000 382 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(6), AMY2A(4), AMY2B(1), ASCC3(7), ATP13A2(3), DDX18(3), DDX23(4), DDX4(5), DDX41(5), DDX47(1), DDX50(4), DDX51(3), DDX52(1), DDX54(2), DDX55(7), DDX56(2), DHX58(4), ENPP1(7), ENPP3(5), ENTPD7(6), EP400(13), ERCC2(3), ERCC3(4), G6PC(2), G6PC2(3), GAA(2), GANC(4), GBA(2), GBE1(4), GCK(3), GPI(3), GUSB(6), GYS1(8), GYS2(1), HK1(3), HK2(5), HK3(5), IFIH1(4), LYZL1(1), MGAM(14), MOV10L1(6), NUDT5(1), NUDT8(1), PGM1(5), PGM3(2), PYGB(4), PYGL(3), PYGM(5), RAD54B(10), RAD54L(3), RUVBL2(1), SETX(18), SI(18), SKIV2L2(4), SMARCA2(11), SMARCA5(5), TREH(2), UGDH(1), UGP2(4), UGT1A1(6), UGT1A10(3), UGT1A3(3), UGT1A4(2), UGT1A6(4), UGT1A7(3), UGT1A9(2), UGT2A1(4), UGT2B10(3), UGT2B11(1), UGT2B15(5), UGT2B17(2), UGT2B28(3), UGT2B4(3), UGT2B7(3), UXS1(3) 178094313 324 207 323 104 42 89 52 86 55 0 0.909 1.000 1.000 383 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY1(5), ADCY2(3), ADCY3(5), ADCY4(4), ADCY5(10), ADCY6(2), ADCY7(11), ADCY8(6), ADCY9(14), AKAP1(3), AKAP10(1), AKAP11(13), AKAP12(10), AKAP2(6), AKAP3(6), AKAP4(8), AKAP6(16), AKAP7(1), AKAP8(4), AKAP9(24), ARHGEF1(10), CALM2(1), GNA11(3), GNA12(2), GNA13(1), GNA14(1), GNAI2(2), GNAI3(1), GNAO1(2), GNAQ(1), GNAZ(3), GNB1(2), GNB2(1), GNB3(3), GNB5(2), GNG10(1), HRAS(2), IL18BP(2), ITPR1(15), KCNJ3(2), KRAS(6), NRAS(2), PALM2(3), PDE1A(5), PDE1B(5), PDE1C(5), PDE4A(1), PDE4B(10), PDE4C(5), PDE4D(8), PDE7B(1), PDE8A(1), PDE8B(1), PLCB3(2), PPP3CA(5), PRKACA(3), PRKACB(1), PRKACG(3), PRKAR1A(4), PRKAR2A(2), PRKAR2B(2), PRKCA(4), PRKCD(5), PRKCE(8), PRKCG(3), PRKCH(3), PRKCI(1), PRKCQ(8), PRKCZ(2), PRKD1(5), PRKD3(6), RHOA(6), SLC9A1(4), USP5(7) 167449645 346 205 342 111 62 96 60 67 59 2 0.861 1.000 1.000 384 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADA(2), ADCY1(5), ADCY2(3), ADCY3(5), ADCY4(4), ADCY5(10), ADCY6(2), ADCY7(11), ADCY8(6), ADK(2), ADSL(3), ADSS(3), AK1(1), AK2(1), AK5(4), ALLC(4), AMPD1(10), AMPD2(1), AMPD3(7), ATIC(3), ATP1B1(3), ATP5A1(3), ATP5B(1), ATP5C1(1), ATP5F1(3), ATP5G2(2), CANT1(2), DCK(1), DGUOK(4), ENPP1(7), ENPP3(5), ENTPD1(4), ENTPD2(3), FHIT(2), GART(3), GDA(2), GMPS(5), GUCY1A2(6), GUCY1A3(2), GUCY1B3(2), GUCY2C(9), GUCY2D(4), GUCY2F(7), GUK1(1), IMPDH1(2), ITPA(1), NPR1(4), NPR2(10), NT5E(4), NUDT2(1), PAICS(3), PAPSS1(2), PAPSS2(2), PDE1A(5), PDE4A(1), PDE4B(10), PDE4C(5), PDE4D(8), PDE5A(6), PDE6B(3), PDE6C(7), PDE7B(1), PDE8A(1), PDE9A(5), PFAS(6), PKLR(5), POLB(1), POLD1(5), POLD2(1), POLE(10), POLG(7), POLL(2), POLQ(12), POLR1B(4), POLR2A(6), POLR2B(5), POLR2C(1), POLR2D(1), POLR2F(3), POLR2G(1), POLR2H(1), POLR2J(1), POLRMT(5), PPAT(5), PRPS2(1), PRUNE(4), RRM1(4), RRM2(1) 181462803 342 204 338 117 63 91 61 65 61 1 0.942 1.000 1.000 385 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 50 ABL1(6), ACTB(5), ACTG1(8), ARHGEF2(5), ARPC5(1), ARPC5L(3), CD14(1), CDH1(109), CLDN1(1), CTNNB1(2), CTTN(2), EZR(1), HCLS1(2), ITGB1(5), KRT18(3), LY96(1), NCK1(2), NCK2(1), NCL(7), OCLN(3), PRKCA(4), RHOA(6), ROCK1(8), ROCK2(9), TLR4(15), TLR5(4), TUBA1A(2), TUBA1B(2), TUBA1C(4), TUBA3C(4), TUBA3D(3), TUBA3E(3), TUBA4A(1), TUBA8(1), TUBAL3(2), TUBB(2), TUBB1(4), TUBB2B(3), TUBB3(2), TUBB6(2), TUBB8(4), WAS(7), WASL(4), YWHAZ(3) 72949404 267 200 244 55 31 55 27 33 121 0 0.212 1.000 1.000 386 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 50 ABL1(6), ACTB(5), ACTG1(8), ARHGEF2(5), ARPC5(1), ARPC5L(3), CD14(1), CDH1(109), CLDN1(1), CTNNB1(2), CTTN(2), EZR(1), HCLS1(2), ITGB1(5), KRT18(3), LY96(1), NCK1(2), NCK2(1), NCL(7), OCLN(3), PRKCA(4), RHOA(6), ROCK1(8), ROCK2(9), TLR4(15), TLR5(4), TUBA1A(2), TUBA1B(2), TUBA1C(4), TUBA3C(4), TUBA3D(3), TUBA3E(3), TUBA4A(1), TUBA8(1), TUBAL3(2), TUBB(2), TUBB1(4), TUBB2B(3), TUBB3(2), TUBB6(2), TUBB8(4), WAS(7), WASL(4), YWHAZ(3) 72949404 267 200 244 55 31 55 27 33 121 0 0.212 1.000 1.000 387 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 149 ADORA1(3), ADORA2A(3), ADORA3(1), ADRA1A(6), ADRA1B(1), ADRA2C(2), ADRB2(2), ADRB3(1), AGTR1(4), AGTR2(2), AVPR1B(5), AVPR2(3), BDKRB1(4), BDKRB2(4), BRS3(4), C3AR1(3), CCKAR(3), CCKBR(2), CCR1(3), CCR2(4), CCR3(2), CCR4(1), CCR5(1), CCR6(1), CCR7(4), CCR8(1), CCR9(1), CCRL2(4), CHML(4), CHRM1(4), CHRM2(6), CHRM3(3), CHRM4(1), CMKLR1(4), CNR1(1), CNR2(1), CX3CR1(2), CXCR3(6), CXCR4(3), DRD1(1), DRD2(3), DRD3(1), DRD5(4), EDNRA(3), EDNRB(2), F2R(4), F2RL1(1), F2RL2(2), FPR1(3), FSHR(9), GALR1(1), GALR2(2), GALR3(1), GALT(1), GHSR(2), GNB2L1(2), GPR17(2), GPR173(1), GPR174(4), GPR3(2), GPR35(1), GPR37(5), GPR37L1(1), GPR50(4), GPR6(2), GPR63(3), GPR83(5), GPR85(2), GPR87(2), GRPR(3), HCRTR1(2), HCRTR2(2), HRH1(4), HRH2(4), HRH3(2), HTR1A(4), HTR1B(3), HTR1D(4), HTR1E(4), HTR1F(4), HTR2A(5), HTR2C(5), HTR5A(4), LHCGR(10), MAS1(2), MC1R(1), MC3R(3), MC4R(2), MLNR(1), NMBR(3), NMUR1(3), NMUR2(3), NPY1R(5), NPY2R(3), NTSR2(2), OPN1SW(3), OPN3(1), OPRD1(3), OPRK1(2), OPRL1(3), OPRM1(3), OXTR(1), P2RY1(4), P2RY10(7), P2RY11(1), P2RY13(4), P2RY2(1), P2RY6(1), PTAFR(1), PTGDR(2), PTGER2(3), PTGER4(1), PTGFR(1), RGR(1), RHO(2), RRH(1), SSTR2(1), SSTR3(2), SSTR4(1) 155066557 324 198 325 125 77 66 55 91 34 1 0.670 1.000 1.000 388 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(11), ABCA10(15), ABCA12(12), ABCA13(32), ABCA2(4), ABCA3(10), ABCA4(12), ABCA5(8), ABCA6(9), ABCA7(10), ABCA8(14), ABCA9(13), ABCB1(9), ABCB10(9), ABCB11(13), ABCB4(10), ABCB5(5), ABCB6(7), ABCB7(7), ABCB8(6), ABCB9(1), ABCC1(8), ABCC10(7), ABCC11(7), ABCC12(10), ABCC2(7), ABCC3(8), ABCC4(10), ABCC5(10), ABCC6(5), ABCC8(12), ABCC9(13), ABCD1(4), ABCD2(4), ABCD3(4), ABCD4(2), ABCG1(3), ABCG2(1), ABCG4(7), ABCG5(2), ABCG8(3), CFTR(14), TAP1(2) 168107572 360 198 358 118 48 107 64 78 61 2 0.660 1.000 1.000 389 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 99 ADCY1(5), ADCY2(3), ADCY3(5), ADCY4(4), ADCY5(10), ADCY6(2), ADCY7(11), ADCY8(6), ADCY9(14), CALM2(1), CALML6(1), CAMK2A(3), CAMK2B(2), CAMK2D(4), CAMK2G(2), CREB1(1), CREB3L1(3), CREB3L2(3), CREB3L3(6), CREB3L4(2), CREBBP(15), CTNNB1(2), DCT(4), DVL1(2), DVL3(1), EDN1(5), EDNRB(2), EP300(13), FZD1(3), FZD10(2), FZD2(4), FZD3(5), FZD4(1), FZD5(1), FZD6(4), FZD7(3), FZD8(1), FZD9(3), GNAI1(2), GNAI2(2), GNAI3(1), GNAO1(2), GNAQ(1), GNAS(11), GSK3B(2), HRAS(2), KIT(8), KITLG(3), KRAS(6), MAP2K1(5), MAP2K2(2), MAPK1(1), MAPK3(1), MC1R(1), MITF(3), NRAS(2), PLCB1(12), PLCB2(7), PLCB3(2), PLCB4(15), PRKACA(3), PRKACB(1), PRKACG(3), PRKCA(4), PRKCG(3), PRKX(5), RAF1(4), TCF7(3), TCF7L1(2), TCF7L2(3), TYR(5), TYRP1(7), WNT10B(1), WNT11(1), WNT16(2), WNT2(1), WNT2B(4), WNT3(1), WNT3A(1), WNT4(1), WNT5B(4), WNT6(1), WNT7A(6), WNT7B(1), WNT8B(2), WNT9A(1) 148619488 320 197 314 110 74 70 59 59 58 0 0.918 1.000 1.000 390 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(2), AKT3(5), BCAR1(6), CAPN1(8), CAPN10(4), CAPN11(3), CAPN2(8), CAPN3(2), CAPN6(3), CAPN7(2), CAPN9(1), CAV1(4), CRK(1), DOCK1(8), GIT2(1), ILK(3), ITGA10(10), ITGA11(7), ITGA2(4), ITGA2B(3), ITGA4(6), ITGA5(4), ITGA6(4), ITGA7(5), ITGA8(10), ITGA9(7), ITGAD(3), ITGAE(2), ITGAL(4), ITGAM(6), ITGAV(7), ITGAX(10), ITGB1(5), ITGB2(7), ITGB3(4), ITGB4(8), ITGB5(2), ITGB6(6), ITGB7(5), ITGB8(4), MAP2K1(5), MAP2K2(2), MAP2K3(3), MAP2K6(1), MAPK10(4), MAPK4(6), MAPK6(6), MAPK7(4), MYLK2(5), PAK1(3), PAK2(2), PAK3(4), PAK4(3), PAK6(5), PDPK1(2), PIK3R2(4), PTK2(7), RAP1B(1), RAPGEF1(5), RHO(2), ROCK1(8), ROCK2(9), SDCCAG8(6), SEPP1(2), SHC1(2), SHC3(1), SORBS1(7), SOS1(5), SRC(1), TLN1(15), TNS1(6), VAV2(3), VAV3(7), VCL(6), ZYX(1) 192659698 347 196 346 120 63 94 55 70 63 2 0.951 1.000 1.000 391 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ADCY1(5), ADCY8(6), ARAF(5), ATF4(3), BRAF(5), CACNA1C(17), CALM2(1), CALML6(1), CAMK2A(3), CAMK2B(2), CAMK2D(4), CAMK2G(2), CAMK4(5), CREBBP(15), EP300(13), GNAQ(1), GRIA1(9), GRIA2(3), GRIN1(3), GRIN2A(16), GRIN2B(11), GRIN2C(5), GRIN2D(5), GRM1(9), GRM5(4), HRAS(2), ITPR1(15), ITPR2(18), ITPR3(14), KRAS(6), MAP2K1(5), MAP2K2(2), MAPK1(1), MAPK3(1), NRAS(2), PLCB1(12), PLCB2(7), PLCB3(2), PLCB4(15), PPP1CB(1), PPP1R12A(7), PPP1R1A(5), PPP3CA(5), PPP3CB(2), PPP3R1(1), PRKACA(3), PRKACB(1), PRKACG(3), PRKCA(4), PRKCG(3), PRKX(5), RAF1(4), RAP1A(2), RAP1B(1), RAPGEF3(2), RPS6KA1(6), RPS6KA2(5), RPS6KA3(8), RPS6KA6(6) 145402754 329 191 323 99 69 87 55 65 53 0 0.470 1.000 1.000 392 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 66 A2M(6), BDKRB1(4), BDKRB2(4), C1QA(1), C1QB(1), C1R(6), C1S(1), C2(3), C3(8), C3AR1(3), C4BPA(4), C4BPB(1), C5(5), C5AR1(3), C6(8), C7(8), C8A(2), C8B(3), C8G(1), C9(5), CD46(2), CD55(3), CD59(1), CFB(1), CFH(13), CFI(1), CPB2(4), CR1(12), CR2(5), F10(5), F12(2), F13A1(5), F13B(5), F2(2), F2R(4), F5(25), F7(2), F8(20), F9(1), FGA(7), FGB(1), FGG(7), KLKB1(2), KNG1(4), MASP1(4), MASP2(2), MBL2(2), PLAT(6), PLAUR(2), PLG(7), PROC(3), PROS1(4), SERPINA1(4), SERPINA5(5), SERPINC1(6), SERPIND1(1), SERPINE1(5), SERPINF2(2), SERPING1(3), TFPI(3), THBD(2), VWF(11) 128452543 283 184 281 82 42 68 65 58 49 1 0.610 1.000 1.000 393 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 107 ALG1(2), ALG10(3), ALG10B(5), ALG11(1), ALG12(3), ALG13(5), ALG14(1), ALG2(2), ALG3(1), ALG6(2), ALG8(1), ALG9(2), B3GNT1(1), B3GNT2(2), B3GNT7(2), B4GALT1(3), B4GALT3(2), B4GALT4(2), B4GALT5(4), B4GALT7(1), C1GALT1(3), C1GALT1C1(3), CHPF(2), CHST1(4), CHST11(1), CHST2(4), CHST3(1), CHST4(1), CHST7(1), CHSY1(3), DAD1(1), DDOST(2), DPAGT1(3), EXT1(7), EXT2(6), EXTL1(1), EXTL2(1), EXTL3(6), FUT11(3), FUT8(3), GALNT1(3), GALNT10(5), GALNT11(5), GALNT12(2), GALNT13(6), GALNT14(1), GALNT2(2), GALNT3(3), GALNT4(1), GALNT5(6), GALNT6(3), GALNT7(4), GALNT8(5), GALNT9(5), GALNTL5(7), GANAB(10), GCNT3(1), GCNT4(3), HS2ST1(3), HS3ST1(2), HS3ST2(4), HS3ST3A1(1), HS3ST3B1(1), HS3ST5(5), HS6ST1(5), HS6ST2(7), HS6ST3(3), MAN1A1(6), MAN1A2(2), MAN1B1(3), MAN2A1(6), MGAT3(4), MGAT4A(3), MGAT4B(4), MGAT5(3), MGAT5B(8), NDST1(4), NDST2(1), NDST3(5), OGT(5), RPN1(4), RPN2(2), ST3GAL1(2), ST3GAL2(2), ST3GAL3(4), ST3GAL4(2), ST6GAL1(3), ST6GALNAC1(5), STT3B(3), UST(2), WBSCR17(7), XYLT1(4), XYLT2(5) 151831110 303 180 301 101 59 73 46 69 53 3 0.880 1.000 1.000 394 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 85 ACVR1B(8), ACVR1C(3), ACVR2A(8), ACVR2B(1), ACVRL1(1), AMHR2(3), BMP2(3), BMP4(2), BMP5(4), BMP6(2), BMP8B(1), BMPR1A(1), BMPR1B(6), BMPR2(8), CHRD(5), COMP(5), CREBBP(15), CUL1(2), DCN(2), E2F4(2), EP300(13), FST(3), GDF5(2), GDF6(1), ID1(1), ID2(2), ID3(1), IFNG(2), INHBA(4), INHBB(1), INHBC(1), INHBE(3), LEFTY2(1), LTBP1(9), MAPK1(1), MAPK3(1), MYC(1), NODAL(1), NOG(1), PITX2(5), PPP2CA(3), PPP2CB(2), PPP2R1A(3), PPP2R2A(1), PPP2R2B(1), PPP2R2C(1), RBL1(6), RHOA(6), ROCK1(8), ROCK2(9), RPS6KB1(4), RPS6KB2(5), SKP1(1), SMAD1(1), SMAD2(7), SMAD3(4), SMAD4(7), SMAD5(2), SMAD7(1), SMAD9(4), SMURF1(3), SMURF2(5), SP1(6), TFDP1(3), TGFB1(2), TGFB2(1), TGFB3(1), TGFBR1(4), TGFBR2(4), THBS1(8), THBS2(2), THBS3(5), THBS4(4), ZFYVE16(4), ZFYVE9(4) 138057261 268 177 263 70 51 64 28 59 66 0 0.486 1.000 1.000 395 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 56 ASH1L(19), ASH2L(4), CARM1(4), CTCFL(5), DOT1L(8), EED(4), EHMT1(9), EHMT2(5), EZH1(3), EZH2(3), FBXO11(5), HCFC1(18), HSF4(1), JMJD6(2), KDM6A(16), MEN1(4), NSD1(13), OGT(5), PAXIP1(6), PPP1CB(1), PRDM2(8), PRDM6(1), PRDM7(2), PRDM9(6), PRMT5(5), PRMT6(2), PRMT7(3), PRMT8(4), RBBP5(3), SATB1(8), SETD1A(4), SETD1B(9), SETD2(18), SETD7(5), SETD8(3), SETDB1(11), SETDB2(2), SETMAR(2), SMYD3(5), STK38(4), SUV39H1(2), SUV39H2(1), SUV420H1(9), SUV420H2(2), SUZ12(7), WHSC1(6), WHSC1L1(5) 174527691 272 176 267 60 38 71 47 54 62 0 0.286 1.000 1.000 396 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 82 ANPEP(8), CD14(1), CD19(6), CD1A(2), CD1B(5), CD1C(4), CD1D(3), CD1E(7), CD2(4), CD22(5), CD33(3), CD34(2), CD36(4), CD37(2), CD38(3), CD3E(3), CD3G(3), CD4(4), CD44(3), CD5(3), CD55(3), CD59(1), CD7(1), CD8A(3), CD8B(3), CD9(2), CR1(12), CR2(5), CSF1(5), CSF1R(3), CSF2RA(2), CSF3(2), CSF3R(6), DNTT(6), EPO(1), EPOR(4), FCER2(1), FCGR1A(5), FLT3(4), FLT3LG(1), GP5(3), HLA-DRB1(10), HLA-DRB5(5), IL11(1), IL11RA(5), IL1A(1), IL1R1(1), IL1R2(4), IL2RA(2), IL3(1), IL3RA(3), IL4(1), IL4R(6), IL5RA(4), IL6(1), IL6R(4), IL7(1), IL7R(4), IL9R(2), ITGA1(6), ITGA2(4), ITGA2B(3), ITGA4(6), ITGA5(4), ITGA6(4), ITGAM(6), ITGB3(4), KIT(8), KITLG(3), MME(1), MS4A1(1), TFRC(2), THPO(3), TPO(7) 116938636 266 163 266 82 38 68 53 59 47 1 0.714 1.000 1.000 397 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 90 CD2BP2(1), CDC40(3), CLK2(6), CLK3(4), CLK4(3), COL2A1(4), CPSF1(11), CPSF2(1), CPSF3(6), CPSF4(3), CSTF1(2), CSTF2(2), CSTF2T(4), CSTF3(8), DDX1(3), DDX20(4), DHX15(9), DHX16(2), DHX38(4), DHX8(7), DHX9(8), DICER1(8), DNAJC8(1), FUS(3), GIPC1(1), METTL3(2), NCBP1(1), NCBP2(1), NONO(2), NUDT21(1), NXF1(7), PABPN1(1), PAPOLA(4), POLR2A(6), PPM1G(2), PRPF18(2), PRPF3(5), PRPF4(3), PRPF4B(9), PRPF8(12), PSKH1(3), PTBP1(4), PTBP2(3), RBM17(1), RBM5(5), RNGTT(2), RNMT(1), RNPS1(2), SF3A1(2), SF3A2(1), SF3A3(1), SF3B1(16), SF3B2(5), SF3B4(3), SF3B5(1), SNRPA(1), SNRPB(2), SNRPD2(1), SNRPG(2), SNRPN(3), SPOP(5), SRPK1(3), SRPK2(5), SRRM1(5), SUPT5H(12), TXNL4A(1), U2AF1(1), U2AF2(1), XRN2(4) 149827976 262 162 255 62 31 71 44 66 48 2 0.361 1.000 1.000 398 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 68 ACACB(10), ACSL1(3), ACSL3(3), ACSL4(5), ACSL5(5), ACSL6(4), ADIPOR1(1), ADIPOR2(2), AGRP(1), AKT1(2), AKT2(4), AKT3(5), CAMKK1(3), CAMKK2(3), CD36(4), CHUK(7), CPT1A(6), CPT1B(4), CPT1C(7), CPT2(5), G6PC(2), G6PC2(3), IKBKB(5), IRS1(4), IRS4(7), JAK1(11), JAK2(7), JAK3(8), LEP(1), LEPR(7), MAPK10(4), MAPK8(2), MAPK9(1), NFKB1(5), NFKB2(5), NFKBIA(3), NFKBIB(1), NFKBIE(2), NPY(1), PCK1(5), PCK2(4), PPARA(4), PPARGC1A(6), PRKAA1(3), PRKAA2(2), PRKAB1(1), PRKAB2(1), PRKAG1(2), PRKAG2(2), PRKAG3(3), PRKCQ(8), PTPN11(1), RELA(3), RXRA(2), RXRG(2), SLC2A4(1), STAT3(5), STK11(2), TNFRSF1A(4), TNFRSF1B(2), TRAF2(1), TYK2(7) 113587289 234 148 231 77 44 52 39 43 54 2 0.864 1.000 1.000 399 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BLNK(1), BTK(7), CALM2(1), CD79B(2), ELK1(4), HRAS(2), JUN(3), LYN(6), MAP2K1(5), MAP3K1(80), MAPK14(1), MAPK3(1), MAPK8(2), NFATC1(5), NFATC2(4), NFATC3(7), NFATC4(6), PLCG1(8), PPP3CA(5), PPP3CB(2), PRKCA(4), RAF1(4), SHC1(2), SOS1(5), SYK(4), SYT1(1), VAV1(6) 53298587 178 145 170 37 20 28 21 30 61 18 0.555 1.000 1.000 400 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 66 ADAM10(3), ATP6AP1(2), ATP6V0A1(5), ATP6V0A2(3), ATP6V0A4(4), ATP6V0B(2), ATP6V0C(1), ATP6V0D2(2), ATP6V0E1(2), ATP6V1A(4), ATP6V1B1(4), ATP6V1B2(3), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1E2(2), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), CASP3(1), CHUK(7), EGFR(5), F11R(4), GIT1(3), IGSF5(3), IKBKB(5), JUN(3), LYN(6), MAP2K4(32), MAPK10(4), MAPK13(1), MAPK14(1), MAPK8(2), MAPK9(1), MET(10), NFKB1(5), NFKB2(5), NFKBIA(3), NOD1(6), PAK1(3), PLCG1(8), PLCG2(8), PTPN11(1), PTPRZ1(11), RELA(3), SRC(1), TCIRG1(2), TJP1(8) 101557658 200 145 194 55 36 51 31 24 58 0 0.582 1.000 1.000 401 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 28 BRAF(5), CPEB1(7), EGFR(5), ERBB2(21), ERBB4(13), ETS1(3), ETS2(7), ETV6(4), ETV7(3), FMN2(17), KRAS(6), MAP2K1(5), MAPK1(1), MAPK3(1), NOTCH1(8), NOTCH2(18), NOTCH3(11), NOTCH4(13), PIWIL1(17), PIWIL2(5), PIWIL3(6), PIWIL4(4), RAF1(4), SOS1(5), SOS2(6), SPIRE1(2) 69251551 197 143 184 49 21 52 44 47 32 1 0.323 1.000 1.000 402 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 48 ADORA3(1), ALG6(2), CCKBR(2), CCR2(4), CCR3(2), CCR5(1), CELSR1(11), CELSR2(14), CELSR3(12), CHRM2(6), CHRM3(3), CIDEB(2), CXCR3(6), EDNRA(3), EMR2(8), EMR3(7), F2R(4), FSHR(9), GHRHR(4), GPR116(7), GPR132(1), GPR133(6), GPR135(1), GPR143(4), GPR17(2), GPR55(3), GPR56(1), GPR61(2), GPR84(7), GRM1(9), GRPR(3), HRH4(2), LGR6(4), LPHN2(11), LPHN3(6), P2RY11(1), P2RY13(4), PTGFR(1), SMO(5), SSTR2(1), TAAR5(4), TSHR(7), VN1R1(1) 87337491 194 138 195 70 28 48 32 55 31 0 0.740 1.000 1.000 403 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 84 AK3(2), CAD(15), CANT1(2), CDA(1), CTPS2(3), DCK(1), DPYD(2), DPYS(3), DTYMK(1), DUT(1), ENTPD1(4), ENTPD3(1), ENTPD4(4), ENTPD5(5), ENTPD6(3), ENTPD8(1), ITPA(1), NME6(1), NME7(4), NT5C1A(2), NT5C1B(4), NT5C2(2), NT5E(4), NUDT2(1), PNPT1(5), POLA1(15), POLA2(5), POLD1(5), POLD2(1), POLE(10), POLE2(2), POLE3(1), POLR1A(10), POLR1B(4), POLR1C(2), POLR1D(4), POLR2A(6), POLR2B(5), POLR2C(1), POLR2D(1), POLR2F(3), POLR2G(1), POLR2H(1), POLR2J(1), POLR3A(5), POLR3B(2), POLR3GL(4), POLR3H(1), POLR3K(1), PRIM1(1), RFC5(1), RRM1(4), RRM2(1), RRM2B(1), TK1(1), TK2(1), TXNRD1(6), TXNRD2(3), TYMS(1), UCK1(1), UCK2(2), UMPS(3), UPB1(2), UPP1(3), UPRT(3) 115898658 198 132 196 75 33 55 31 42 36 1 0.987 1.000 1.000 404 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ADCY4(4), ADCY6(2), ADCY8(6), CACNA1A(16), CACNA1B(14), GNAS(11), GNAT3(1), GNB1(2), GNB3(3), GRM4(3), ITPR3(14), KCNB1(7), PDE1A(5), PLCB2(7), PRKACA(3), PRKACB(1), PRKACG(3), PRKX(5), SCNN1A(3), SCNN1B(2), SCNN1G(1), TAS1R1(2), TAS1R2(4), TAS1R3(1), TAS2R1(4), TAS2R10(4), TAS2R13(2), TAS2R14(2), TAS2R16(5), TAS2R3(3), TAS2R38(2), TAS2R39(1), TAS2R40(2), TAS2R41(2), TAS2R42(2), TAS2R43(4), TAS2R46(2), TAS2R5(2), TAS2R50(1), TAS2R8(2), TAS2R9(2), TRPM5(10) 80499015 172 127 170 51 34 43 31 34 30 0 0.341 1.000 1.000 405 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 92 ANK2(28), B3GALT4(2), CDR1(2), DGKI(7), IL6ST(9), RPL10(2), RPL12(1), RPL13A(4), RPL15(1), RPL17(1), RPL18(1), RPL18A(4), RPL19(2), RPL23(1), RPL24(1), RPL26(1), RPL3(2), RPL31(1), RPL32(1), RPL35(1), RPL36(1), RPL3L(3), RPL4(1), RPL41(1), RPL5(2), RPL7(1), RPL8(2), RPL9(1), RPLP0(3), RPLP2(1), RPS10(1), RPS12(1), RPS16(1), RPS18(1), RPS2(1), RPS25(1), RPS29(1), RPS4X(2), RPS5(6), RPS6(4), RPS6KA1(6), RPS6KA2(5), RPS6KA3(8), RPS6KA6(6), RPS6KB1(4), RPS6KB2(5), RPS8(1), SLC36A2(5), TBC1D10C(4), TSPAN9(3), UBA52(2), UBC(12) 75185541 168 124 166 50 36 47 32 27 25 1 0.672 1.000 1.000 406 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 APH1A(2), CREBBP(15), CTBP1(1), CTBP2(1), DLL1(5), DLL3(2), DLL4(2), DTX1(4), DTX2(3), DTX3(3), DTX3L(4), DTX4(2), DVL1(2), DVL3(1), EP300(13), HDAC1(6), HDAC2(2), HES1(1), JAG1(9), JAG2(1), MAML1(3), MAML2(4), MAML3(7), NCOR2(8), NCSTN(6), NOTCH1(8), NOTCH2(18), NOTCH3(11), NOTCH4(13), NUMB(5), NUMBL(3), PSEN1(2), PSEN2(4), PSENEN(2), PTCRA(3), RBPJL(5), RFNG(2), SNW1(2) 90168295 185 123 184 67 41 34 40 29 41 0 0.958 1.000 1.000 407 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 66 ACAA1(1), ACADL(1), ACOX1(3), ACOX2(4), ACOX3(5), ACSL1(3), ACSL3(3), ACSL4(5), ACSL5(5), ACSL6(4), ANGPTL4(1), APOA1(3), APOA5(3), CD36(4), CPT1A(6), CPT1B(4), CPT1C(7), CPT2(5), CYP27A1(1), CYP4A11(7), CYP4A22(2), CYP7A1(3), CYP8B1(3), DBI(1), EHHADH(4), FABP1(2), FABP2(1), FABP3(1), FABP6(1), FABP7(1), FADS2(7), GK(5), GK2(4), HMGCS2(3), ILK(3), LPL(1), MMP1(2), NR1H3(2), OLR1(2), PCK1(5), PCK2(4), PDPK1(2), PLTP(3), PPARA(4), PPARD(2), PPARG(5), RXRA(2), RXRG(2), SCD(1), SCP2(1), SLC27A1(2), SLC27A2(2), SLC27A4(5), SLC27A5(4), SORBS1(7), UBC(12) 91519820 186 119 185 66 31 46 33 39 35 2 0.904 1.000 1.000 408 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AANAT(1), ACAT1(2), AFMID(1), ALDH1A3(6), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(3), ALDH9A1(1), AOC2(6), AOC3(3), AOX1(7), ASMT(1), CARM1(4), CAT(2), CYP1A1(1), CYP1A2(2), CYP1B1(2), DDC(3), EHHADH(4), GCDH(2), HAAO(2), HADH(2), HADHA(2), HEMK1(2), HSD17B10(1), HSD17B4(8), INMT(4), KMO(7), KYNU(3), LCMT1(1), LCMT2(10), LNX1(6), MAOA(2), MAOB(4), METTL2B(4), NFX1(4), OGDH(7), OGDHL(6), PRMT2(2), PRMT3(3), PRMT5(5), PRMT6(2), PRMT7(3), PRMT8(4), TDO2(2), TPH1(2), TPH2(3), WARS2(2), WBSCR22(2) 86508648 161 117 160 59 20 50 40 28 21 2 0.947 1.000 1.000 409 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 58 APC(23), AXIN1(5), CCND1(1), CCND2(2), CCND3(4), CSNK1E(4), CTNNB1(2), DVL1(2), DVL3(1), FBXW2(4), FZD1(3), FZD10(2), FZD2(4), FZD3(5), FZD5(1), FZD6(4), FZD7(3), FZD8(1), FZD9(3), GSK3B(2), JUN(3), LDLR(4), MAPK10(4), MAPK9(1), MYC(1), PAFAH1B1(3), PPP2R5C(6), PPP2R5E(2), PRKCA(4), PRKCD(5), PRKCE(8), PRKCG(3), PRKCH(3), PRKCI(1), PRKCQ(8), PRKCZ(2), PRKD1(5), RHOA(6), SFRP4(2), TCF7(3), WNT10B(1), WNT11(1), WNT16(2), WNT2(1), WNT2B(4), WNT3(1), WNT4(1), WNT5B(4), WNT6(1), WNT7A(6), WNT7B(1) 80149103 173 117 172 56 38 39 27 32 33 4 0.832 1.000 1.000 410 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1A(1), ADH4(1), ADH5(5), ADH6(2), ADH7(3), ADHFE1(2), AGK(4), AGPAT1(1), AGPAT3(2), AGPAT4(2), AGPAT6(3), AKR1A1(1), AKR1B1(2), ALDH1A3(6), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(3), ALDH9A1(1), CEL(4), DAK(4), DGAT1(2), DGAT2(2), DGKA(2), DGKB(5), DGKD(8), DGKE(4), DGKG(8), DGKH(4), DGKI(7), DGKQ(1), DGKZ(1), GK(5), GK2(4), GLA(5), GLB1(4), GPAM(6), LCT(17), LIPA(3), LIPC(2), LIPF(1), LIPG(3), LPL(1), PNLIP(5), PNLIPRP1(4), PNPLA3(3), PPAP2A(2), PPAP2C(1) 83773054 162 116 160 48 32 36 35 28 29 2 0.436 1.000 1.000 411 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT1(2), AKT2(4), AKT3(5), ASAH1(1), BRAF(5), DAG1(2), DRD2(3), EGFR(5), EPHB2(5), ITPKA(1), ITPKB(8), ITPR1(15), ITPR2(18), ITPR3(14), KCNJ3(2), KCNJ5(1), KCNJ9(1), MAPK1(1), PI3(1), PIK3CB(8), PITX2(5), PLCB1(12), PLCB2(7), PLCB3(2), PLCB4(15), RAF1(4), RGS20(4), SHC1(2), SOS1(5), SOS2(6), SRC(1), STAT3(5), TERF2IP(3) 83391667 173 116 171 42 30 46 18 47 32 0 0.154 1.000 1.000 412 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(6), AMY2A(4), AMY2B(1), ENPP1(7), ENPP3(5), G6PC(2), GAA(2), GANAB(10), GBE1(4), GCK(3), GPI(3), GUSB(6), GYS1(8), GYS2(1), HK1(3), HK2(5), HK3(5), MGAM(14), PGM1(5), PGM3(2), PYGB(4), PYGL(3), PYGM(5), RNPC3(2), SI(18), UCHL3(2), UGDH(1), UGT1A1(6), UGT1A10(3), UGT1A3(3), UGT1A4(2), UGT1A6(4), UGT1A7(3), UGT1A9(2), UGT2B15(5), UGT2B4(3), UXS1(3) 83062445 165 115 164 61 24 36 29 47 29 0 0.964 1.000 1.000 413 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 55 BMP2(3), BMP4(2), BMP5(4), BMP6(2), BMP8B(1), BTRC(4), CSNK1A1(3), CSNK1A1L(4), CSNK1E(4), CSNK1G1(1), CSNK1G2(1), CSNK1G3(1), GLI1(5), GLI2(12), GLI3(11), GSK3B(2), HHIP(1), IHH(2), LRP2(33), PRKACA(3), PRKACB(1), PRKACG(3), PRKX(5), PTCH1(11), PTCH2(2), SHH(1), SMO(5), STK36(1), SUFU(3), WNT10B(1), WNT11(1), WNT16(2), WNT2(1), WNT2B(4), WNT3(1), WNT3A(1), WNT4(1), WNT5B(4), WNT6(1), WNT7A(6), WNT7B(1), WNT8B(2), WNT9A(1), ZIC2(1) 80696078 159 114 158 56 47 36 24 30 22 0 0.839 1.000 1.000 414 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPL(1), ALPP(3), ALPPL2(2), ASCC3(7), ATP13A2(3), DDX18(3), DDX23(4), DDX4(5), DDX41(5), DDX47(1), DDX50(4), DDX51(3), DDX52(1), DDX54(2), DDX55(7), DDX56(2), DHX58(4), ENTPD7(6), EP400(13), ERCC2(3), ERCC3(4), FPGS(4), GCH1(1), IFIH1(4), MOV10L1(6), NUDT5(1), NUDT8(1), QDPR(1), RAD54B(10), RAD54L(3), RUVBL2(1), SETX(18), SKIV2L2(4), SMARCA2(11), SMARCA5(5) 88749867 153 113 153 42 23 46 28 31 25 0 0.499 1.000 1.000 415 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 70 B2M(3), CALR(1), CANX(3), CD4(4), CD74(2), CD8A(3), CD8B(3), CIITA(5), CREB1(1), CTSB(2), CTSS(3), HLA-A(3), HLA-B(3), HLA-C(6), HLA-DMB(3), HLA-DPB1(1), HLA-DQA2(1), HLA-DQB1(3), HLA-DRB1(10), HLA-DRB5(5), HLA-F(3), HLA-G(1), HSP90AA1(3), HSP90AB1(3), HSPA5(5), IFI30(1), IFNA1(1), IFNA10(3), IFNA13(3), IFNA14(3), IFNA16(2), IFNA17(3), IFNA2(3), IFNA21(4), IFNA4(2), IFNA6(1), IFNA7(2), IFNA8(2), KIR2DL3(2), KIR3DL1(3), KIR3DL2(6), KIR3DL3(3), KLRC1(5), KLRC3(1), KLRD1(1), LGMN(2), LTA(2), NFYB(1), NFYC(3), RFX5(3), RFXANK(4), RFXAP(1), TAP1(2) 56860194 149 113 148 51 15 45 38 28 22 1 0.879 1.000 1.000 416 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 43 CBL(4), CD28(2), CTLA4(1), DAG1(2), DTYMK(1), EPHB2(5), FBXW7(15), GRAP2(2), ITK(7), ITPKA(1), ITPKB(8), LAT(1), LCK(2), LCP2(2), MAPK1(1), NCK1(2), NFAT5(7), NFKB1(5), NFKB2(5), NFKBIA(3), NFKBIB(1), NFKBIE(2), PAK1(3), PAK2(2), PAK3(4), PAK4(3), PAK6(5), PAK7(4), PLCG1(8), PTPRC(8), RAF1(4), RASGRP2(5), RASGRP3(2), RASGRP4(5), SOS1(5), SOS2(6), VAV1(6), ZAP70(3) 78251150 152 112 150 59 30 39 21 35 27 0 0.986 1.000 1.000 417 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 64 ACHE(3), AGPAT1(1), AGPAT3(2), AGPAT4(2), AGPAT6(3), CDS1(3), CDS2(3), CHAT(2), CHKA(1), CHKB(4), CHPT1(4), CRLS1(3), DGKA(2), DGKB(5), DGKD(8), DGKE(4), DGKG(8), DGKH(4), DGKI(7), DGKQ(1), DGKZ(1), ESCO1(4), ESCO2(1), ETNK1(2), ETNK2(3), GNPAT(5), GPAM(6), GPD1(5), GPD2(3), LCAT(1), PCYT1A(2), PCYT1B(6), PEMT(1), PHOSPHO1(1), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(2), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(1), PLD1(7), PLD2(2), PNPLA3(3), PPAP2A(2), PPAP2C(1), PTDSS1(5), PTDSS2(3), SH3GLB1(2) 92770118 155 111 154 47 25 42 26 39 22 1 0.569 1.000 1.000 418 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(10), COL4A2(10), COL4A3(6), COL4A4(9), COL4A5(12), COL4A6(10), F10(5), F12(2), F2(2), F2R(4), F5(25), F8(20), F9(1), FGA(7), FGB(1), FGG(7), KLKB1(2), PROC(3), PROS1(4), SERPINC1(6), SERPING1(3) 64658603 149 109 149 38 22 34 39 27 27 0 0.331 1.000 1.000 419 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AASDHPPT(4), AASS(5), ACAT1(2), AKR1B10(1), ALDH1A3(6), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(3), ALDH9A1(1), BBOX1(2), DLST(3), DOT1L(8), EHHADH(4), EHMT1(9), EHMT2(5), GCDH(2), HADH(2), HADHA(2), HSD17B10(1), HSD17B4(8), HSD3B7(1), NSD1(13), OGDH(7), OGDHL(6), PIPOX(2), PLOD1(2), PLOD2(2), PLOD3(5), RDH11(3), RDH12(2), RDH13(2), RDH14(2), SETD1A(4), SETD7(5), SETDB1(11), SHMT1(1), SHMT2(3), SPCS3(1), SUV39H1(2), SUV39H2(1), TMLHE(1) 79178595 149 108 147 54 23 38 32 32 24 0 0.927 1.000 1.000 420 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 65 AGTR1(4), AGTR2(2), ATP8A1(4), AVPR1B(5), AVPR2(3), BDKRB1(4), BDKRB2(4), BRS3(4), C3AR1(3), CCKAR(3), CCKBR(2), CCR1(3), CCR2(4), CCR3(2), CCR4(1), CCR5(1), CCR6(1), CCR7(4), CCR8(1), CX3CR1(2), CXCR3(6), CXCR4(3), CXCR6(1), EDNRA(3), EDNRB(2), FPR1(3), FSHR(9), GALR1(1), GALR2(2), GALR3(1), GALT(1), GHSR(2), GNB2L1(2), GRPR(3), LHCGR(10), MC1R(1), MC2R(2), MC3R(3), MC4R(2), NMBR(3), NPY1R(5), NPY2R(3), NTSR2(2), OPRD1(3), OPRK1(2), OPRL1(3), OPRM1(3), OXTR(1), SSTR2(1), SSTR3(2), SSTR4(1), TACR1(2), TACR2(4), TACR3(2), TSHR(7) 71700849 158 108 158 53 30 39 25 48 15 1 0.409 1.000 1.000 421 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 54 ADH1A(1), ADH4(1), ADH5(5), ADH6(2), ADH7(3), ADHFE1(2), ALDH1A3(6), ALDH3A1(3), ALDH3B2(4), AOC2(6), AOC3(3), AOX1(7), CARM1(4), DBH(6), DCT(4), DDC(3), ECH1(1), ESCO1(4), ESCO2(1), FAH(2), GOT1(2), GOT2(1), GSTZ1(1), HEMK1(2), HGD(4), HPD(4), LCMT1(1), LCMT2(10), MAOA(2), MAOB(4), METTL2B(4), PNMT(1), PNPLA3(3), PRMT2(2), PRMT3(3), PRMT5(5), PRMT6(2), PRMT7(3), PRMT8(4), SH3GLB1(2), TAT(3), TH(2), TPO(7), TYR(5), TYRP1(7), WBSCR22(2) 82742512 154 107 151 40 26 37 38 24 27 2 0.402 1.000 1.000 422 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(13), CARM1(4), CCND1(1), CREBBP(15), EP300(13), ERCC3(4), ESR1(5), GRIP1(6), GTF2A1(2), GTF2E1(2), GTF2F1(1), HDAC1(6), HDAC2(2), HDAC3(1), HDAC4(5), HDAC5(6), HDAC6(16), MEF2C(4), NCOR2(8), NRIP1(10), PELP1(6), POLR2A(6), TBP(2) 66601673 138 104 137 47 18 33 27 26 34 0 0.952 1.000 1.000 423 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(3), AKT1(2), BDKRB2(4), CALM2(1), CAV1(4), CHRM1(4), CHRNA1(4), FLT1(5), FLT4(3), KDR(8), NOS3(3), PDE2A(4), PDE3A(12), PDE3B(4), PRKACB(1), PRKACG(3), PRKAR1A(4), PRKAR2A(2), PRKAR2B(2), PRKG1(4), PRKG2(7), RYR2(53), SYT1(1) 58928406 138 103 137 65 19 42 26 30 19 2 0.999 1.000 1.000 424 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 69 ADH1A(1), ADH4(1), ADH5(5), ADH6(2), ADH7(3), ADHFE1(2), AKR1C1(5), AKR1C2(3), AKR1C3(1), AKR1C4(3), ALDH1A3(6), ALDH3A1(3), ALDH3B2(4), CYP1A1(1), CYP1A2(2), CYP1B1(2), CYP2B6(5), CYP2C18(2), CYP2C19(6), CYP2C8(3), CYP2C9(3), CYP2E1(2), CYP2F1(5), CYP2S1(6), CYP3A4(4), CYP3A43(3), CYP3A5(2), CYP3A7(5), DHDH(1), EPHX1(3), GSTA1(2), GSTA2(1), GSTA3(1), GSTA4(1), GSTA5(2), GSTK1(1), GSTM4(1), GSTO2(2), GSTP1(1), GSTT1(1), GSTZ1(1), MGST3(2), UGT1A1(6), UGT1A10(3), UGT1A3(3), UGT1A4(2), UGT1A6(4), UGT1A7(3), UGT1A9(2), UGT2A1(4), UGT2B10(3), UGT2B11(1), UGT2B15(5), UGT2B17(2), UGT2B28(3), UGT2B4(3), UGT2B7(3) 81732469 157 102 155 55 15 45 32 44 21 0 0.844 1.000 1.000 425 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 63 ACSS1(1), ACSS2(2), ACYP1(2), ADH1A(1), ADH4(1), ADH5(5), ADH6(2), ADH7(3), ADHFE1(2), AKR1A1(1), ALDH1A3(6), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(3), ALDH3B2(4), ALDH9A1(1), ALDOA(5), ALDOB(3), ALDOC(2), BPGM(1), DLAT(2), DLD(1), ENO2(1), ENO3(2), FBP1(2), G6PC(2), G6PC2(3), GALM(1), GAPDH(1), GAPDHS(2), GCK(3), GPI(3), HK1(3), HK2(5), HK3(5), LDHA(2), LDHC(4), PDHA1(3), PDHA2(4), PDHB(1), PFKL(1), PFKM(8), PFKP(6), PGAM2(1), PGAM4(2), PGK1(7), PGK2(1), PGM1(5), PGM3(2), PKLR(5), TPI1(2) 82063278 140 101 137 33 18 36 32 27 27 0 0.0866 1.000 1.000 426 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 34 ACTG1(8), ACTG2(4), ACTR2(2), ACTR3(2), AKT1(2), ANGPTL2(1), CFL1(1), CFL2(1), FLNA(17), FLNC(21), FSCN1(1), FSCN3(1), GDI1(4), GDI2(2), LIMK1(7), MYH2(10), MYLK(11), MYLK2(5), PAK1(3), PAK2(2), PAK3(4), PAK4(3), PAK6(5), PAK7(4), RHO(2), ROCK1(8), ROCK2(9), RPS4X(2), WASF1(6), WASL(4) 65487837 152 101 151 52 31 30 27 29 34 1 0.896 1.000 1.000 427 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 AK3(2), CAD(15), CANT1(2), CDA(1), CTPS2(3), DCK(1), DPYD(2), DPYS(3), DTYMK(1), DUT(1), ENTPD1(4), ITPA(1), NT5E(4), NUDT2(1), POLB(1), POLD1(5), POLD2(1), POLE(10), POLG(7), POLL(2), POLQ(12), POLR1B(4), POLR2A(6), POLR2B(5), POLR2C(1), POLR2D(1), POLR2F(3), POLR2G(1), POLR2H(1), POLR2J(1), POLRMT(5), RRM1(4), RRM2(1), TK1(1), TK2(1), TXNRD1(6), TYMS(1), UCK1(1), UCK2(2), UMPS(3), UPB1(2), UPP1(3) 81059720 132 100 130 53 21 37 19 27 27 1 0.990 1.000 1.000 428 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 52 AKR1C4(3), AKR1D1(1), ARSE(4), CARM1(4), CYP11B1(5), CYP11B2(4), HEMK1(2), HSD11B1(3), HSD11B2(2), HSD17B1(1), HSD17B2(4), HSD17B3(2), HSD3B1(3), HSD3B2(4), LCMT1(1), LCMT2(10), METTL2B(4), PRMT2(2), PRMT3(3), PRMT5(5), PRMT6(2), PRMT7(3), PRMT8(4), SRD5A1(4), STS(1), SULT1E1(3), SULT2B1(2), UGT1A1(6), UGT1A10(3), UGT1A3(3), UGT1A4(2), UGT1A6(4), UGT1A7(3), UGT1A9(2), UGT2A1(4), UGT2B10(3), UGT2B11(1), UGT2B15(5), UGT2B17(2), UGT2B28(3), UGT2B4(3), UGT2B7(3), WBSCR22(2) 69316391 135 99 134 49 12 44 31 27 20 1 0.912 1.000 1.000 429 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(2), ATF1(3), CREB1(1), CREB5(5), DUSP1(1), DUSP10(9), EEF2K(6), ELK1(4), IL1R1(1), MAP2K3(3), MAP2K4(32), MAP2K6(1), MAP3K10(3), MAP3K4(8), MAP3K5(12), MAP3K7(3), MAPK1(1), MAPK13(1), MAPK14(1), MAPKAPK2(1), MKNK1(2), MKNK2(4), MYEF2(3), NFKB1(5), NR2C2(1), SRF(1), TRAF6(4) 47317061 118 97 112 35 17 22 16 24 39 0 0.812 1.000 1.000 430 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(5), F12(2), F13B(5), F2(2), F5(25), F7(2), F8(20), F9(1), FGA(7), FGB(1), FGG(7), LPA(16), PLAT(6), PLG(7), SERPINB2(1), SERPINE1(5), SERPINF2(2), VWF(11) 50018893 125 96 123 35 19 24 33 25 24 0 0.485 1.000 1.000 431 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(3), ATP4A(8), ATP4B(3), ATP5A1(3), ATP5B(1), ATP5C1(1), ATP5F1(3), ATP5G2(2), ATP5L(1), ATP5O(2), ATP6AP1(2), ATP6V0A1(5), ATP6V0A2(3), ATP6V0A4(4), ATP6V0B(2), ATP6V0C(1), ATP6V0D2(2), ATP6V0E1(2), ATP6V1A(4), ATP6V1B1(4), ATP6V1B2(3), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1E2(2), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), COX10(7), COX15(3), COX17(1), COX4I2(2), COX5A(1), COX5B(1), COX6A1(1), COX6C(1), COX7A2(1), COX7B2(3), NDUFA1(2), NDUFA10(1), NDUFA2(1), NDUFA4(1), NDUFA4L2(1), NDUFA6(1), NDUFA7(1), NDUFA9(2), NDUFB1(2), NDUFB10(1), NDUFB3(1), NDUFB5(3), NDUFB6(2), NDUFB8(1), NDUFB9(3), NDUFS1(1), NDUFS2(7), NDUFS3(1), NDUFS5(1), NDUFS7(2), NDUFS8(1), NDUFV1(5), NDUFV2(1), NDUFV3(1), PPA1(4), PPA2(2), SDHB(2), TCIRG1(2), UQCRB(1), UQCRC1(1), UQCRC2(4), UQCRFS1(1) 80724127 153 95 153 45 26 45 26 29 27 0 0.485 1.000 1.000 432 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR2(2), ACTR3(2), ARHGAP1(2), ARHGAP4(4), ARHGAP5(12), ARHGAP6(5), ARHGEF1(10), ARHGEF11(6), ARHGEF5(10), ARPC1A(3), ARPC1B(2), ARPC2(5), BAIAP2(2), CFL1(1), DIAPH1(5), GSN(2), LIMK1(7), MYLK(11), OPHN1(4), PIP5K1A(6), PIP5K1B(2), PPP1R12B(4), ROCK1(8), SRC(1), TLN1(15), VCL(6) 65907665 137 95 134 54 20 33 22 21 41 0 0.991 1.000 1.000 433 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 52 ACYP1(2), ADH1A(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(2), AKR1A1(1), ALDH1A1(4), ALDH1A2(1), ALDH1A3(6), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(3), ALDH3B2(4), ALDH9A1(1), ALDOA(5), ALDOB(3), ALDOC(2), BPGM(1), DLAT(2), DLD(1), ENO2(1), ENO3(2), FBP1(2), G6PC(2), GAPDH(1), GCK(3), GPI(3), HK1(3), HK2(5), HK3(5), LDHA(2), LDHC(4), PDHA1(3), PDHA2(4), PDHB(1), PFKM(8), PFKP(6), PGK1(7), PGM1(5), PGM3(2), PKLR(5), TPI1(2) 68900192 126 94 123 30 18 30 29 22 27 0 0.125 1.000 1.000 434 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 52 ACYP1(2), ADH1A(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(2), AKR1A1(1), ALDH1A1(4), ALDH1A2(1), ALDH1A3(6), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(3), ALDH3B2(4), ALDH9A1(1), ALDOA(5), ALDOB(3), ALDOC(2), BPGM(1), DLAT(2), DLD(1), ENO2(1), ENO3(2), FBP1(2), G6PC(2), GAPDH(1), GCK(3), GPI(3), HK1(3), HK2(5), HK3(5), LDHA(2), LDHC(4), PDHA1(3), PDHA2(4), PDHB(1), PFKM(8), PFKP(6), PGK1(7), PGM1(5), PGM3(2), PKLR(5), TPI1(2) 68900192 126 94 123 30 18 30 29 22 27 0 0.125 1.000 1.000 435 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(8), AARS2(5), CARS(4), CARS2(5), DARS(3), DARS2(2), EARS2(3), EPRS(11), FARS2(4), FARSA(3), FARSB(5), GARS(2), HARS(2), IARS(8), IARS2(5), LARS(5), LARS2(3), MARS(9), MARS2(1), NARS(1), NARS2(2), PARS2(2), QARS(10), RARS(5), RARS2(3), SARS(4), SARS2(2), TARS(8), TARS2(9), VARS(2), VARS2(1), WARS2(2), YARS(4), YARS2(1) 74385289 144 94 142 39 18 52 19 30 25 0 0.500 1.000 1.000 436 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(3), ACTN1(5), ACTN2(10), BCAR1(6), BCR(3), CAPN1(8), CAV1(4), CRKL(1), HRAS(2), ITGA1(6), ITGB1(5), JUN(3), MAP2K1(5), MAP2K2(2), MAPK1(1), MAPK3(1), MAPK8(2), PPP1R12B(4), PTK2(7), RAF1(4), RAP1A(2), ROCK1(8), SHC1(2), SOS1(5), SRC(1), TLN1(15), VCL(6), ZYX(1) 66725288 122 94 122 41 26 29 15 25 25 2 0.845 1.000 1.000 437 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(6), AKT1(2), AKT2(4), AKT3(5), DAG1(2), GNAQ(1), ITPKA(1), ITPKB(8), ITPR1(15), ITPR2(18), ITPR3(14), NFKB1(5), NFKB2(5), NFKBIA(3), NFKBIB(1), NFKBIE(2), PDK1(2), PHKA2(13), PIK3CB(8), PITX2(5), PLD1(7), PLD2(2), PLD3(2), VN1R1(1) 63239153 132 94 131 35 22 39 12 34 25 0 0.289 1.000 1.000 438 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(3), AGPAT1(1), AGPAT3(2), AGPAT4(2), AGPS(1), CDS1(3), CDS2(3), CHAT(2), CHKA(1), CHKB(4), CLC(1), CPT1B(4), DGKA(2), DGKB(5), DGKD(8), DGKE(4), DGKG(8), DGKH(4), DGKQ(1), DGKZ(1), ETNK1(2), GNPAT(5), GPD1(5), GPD2(3), LCAT(1), LGALS13(3), PAFAH1B1(3), PCYT1A(2), PCYT1B(6), PEMT(1), PLA2G1B(1), PLA2G2A(1), PLA2G2E(1), PLA2G3(2), PLA2G4A(7), PLA2G6(1), PLCB2(7), PLCG1(8), PLCG2(8), PPAP2A(2), PPAP2C(1) 70156202 130 93 129 42 22 34 20 30 23 1 0.693 1.000 1.000 439 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 39 ALK(8), AR(6), ESR1(5), ESR2(4), HNF4A(2), NR1D1(5), NR1D2(2), NR1H2(7), NR1H3(2), NR1I2(2), NR1I3(2), NR2C2(1), NR2E1(3), NR2F1(1), NR2F2(1), NR3C1(3), NR4A1(2), NR4A2(3), NR5A1(1), NR5A2(7), PGR(6), PPARA(4), PPARD(2), PPARG(5), RARA(1), RARB(6), RARG(3), ROR1(9), RORA(1), RORC(2), RXRA(2), RXRG(2), THRA(3), THRB(2) 56536967 115 93 114 42 28 18 19 21 29 0 0.914 1.000 1.000 440 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(2), AGPAT1(1), AGPAT3(2), AGPAT4(2), AKR1A1(1), AKR1B1(2), ALDH1A1(4), ALDH1A2(1), ALDH1A3(6), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(3), ALDH9A1(1), CEL(4), DGAT1(2), DGKA(2), DGKB(5), DGKD(8), DGKE(4), DGKG(8), DGKH(4), DGKQ(1), DGKZ(1), GK(5), GLA(5), GLB1(4), LCT(17), LIPC(2), LIPF(1), LIPG(3), LPL(1), PNLIP(5), PNLIPRP1(4), PPAP2A(2), PPAP2C(1) 68535641 126 92 124 43 26 26 26 21 26 1 0.759 1.000 1.000 441 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 AANAT(1), ACAT1(2), ALDH1A1(4), ALDH1A2(1), ALDH1A3(6), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(3), ALDH9A1(1), AOC2(6), AOC3(3), AOX1(7), ASMT(1), CAT(2), CYP1A1(1), CYP1A2(2), CYP2A13(8), CYP2A6(1), CYP2A7(1), CYP2B6(5), CYP2C18(2), CYP2C19(6), CYP2C8(3), CYP2C9(3), CYP2D6(3), CYP2E1(2), CYP2F1(5), CYP3A4(4), CYP3A5(2), CYP3A7(5), CYP4B1(4), CYP51A1(2), DDC(3), EHHADH(4), GCDH(2), HAAO(2), HADHA(2), KMO(7), KYNU(3), MAOA(2), MAOB(4), TDO2(2), TPH1(2), WARS2(2) 79049771 136 92 135 54 14 38 24 36 23 1 0.970 1.000 1.000 442 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA1(1), ACAA2(2), ACADL(1), ACADS(2), ACADSB(4), ACADVL(4), ACAT1(2), ACOX1(3), ACOX3(5), ACSL1(3), ACSL3(3), ACSL4(5), ACSL5(5), ACSL6(4), ADH1A(1), ADH4(1), ADH5(5), ADH6(2), ADH7(3), ADHFE1(2), ALDH1A3(6), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(3), ALDH9A1(1), CPT1A(6), CPT1B(4), CPT1C(7), CPT2(5), CYP4A11(7), CYP4A22(2), EHHADH(4), GCDH(2), HADH(2), HADHA(2), HADHB(3), HSD17B10(1), HSD17B4(8) 70280258 126 91 125 36 21 32 30 27 15 1 0.418 1.000 1.000 443 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(4), AADAC(5), ABAT(7), ACADS(2), ACAT1(2), ACSM1(2), AKR1B10(1), ALDH1A3(6), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(3), ALDH5A1(2), ALDH9A1(1), BDH1(1), DDHD1(4), EHHADH(4), GAD1(3), GAD2(3), HADH(2), HADHA(2), HMGCS1(6), HMGCS2(3), HSD17B10(1), HSD17B4(8), HSD3B7(1), ILVBL(5), L2HGDH(2), OXCT1(5), OXCT2(5), PDHA1(3), PDHA2(4), PDHB(1), PLA1A(3), PPME1(2), RDH11(3), RDH12(2), RDH13(2), RDH14(2) 58240062 117 89 114 30 19 29 21 28 20 0 0.251 1.000 1.000 444 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT1(2), AKT2(4), AKT3(5), ANKRD6(5), APC(23), AXIN1(5), AXIN2(5), CER1(2), CSNK1A1(3), CTNNB1(2), DACT1(2), DKK2(1), DKK3(4), DKK4(4), DVL1(2), FSTL1(1), GSK3A(5), GSK3B(2), LRP1(27), MVP(1), NKD1(1), NKD2(2), PSEN1(2), PTPRA(6), SENP2(1), SFRP1(3), WIF1(3) 56840163 123 89 123 37 23 33 15 25 24 3 0.745 1.000 1.000 445 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(4), CDC7(2), CDK2(2), CDT1(1), DIAPH2(9), GMNN(2), MCM10(7), MCM2(3), MCM3(3), MCM4(5), MCM5(3), MCM6(4), MCM7(7), NACA(8), POLA2(5), POLD1(5), POLD2(1), POLE(10), POLE2(2), PRIM1(1), RFC1(7), RFC4(3), RFC5(1), RPA1(1), RPA2(1), RPA3(2), RPA4(3), UBA52(2), UBC(12) 72275642 116 87 115 40 14 40 15 25 21 1 0.960 1.000 1.000 446 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 AKT1(2), APC(23), ASAH1(1), DAG1(2), DLG4(1), EPHB2(5), GNAI1(2), GNAQ(1), ITPR1(15), ITPR2(18), ITPR3(14), KCNJ3(2), KCNJ5(1), KCNJ9(1), MAPK1(1), PITX2(5), PTX3(1), RHO(2), RYR1(30) 65570823 127 87 126 46 25 28 16 38 19 1 0.888 1.000 1.000 447 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(2), AKR1B10(1), B4GALT1(3), G6PC(2), G6PC2(3), GAA(2), GALK2(3), GALT(1), GANC(4), GCK(3), GLA(5), GLB1(4), HK1(3), HK2(5), HK3(5), HSD3B7(1), LALBA(1), LCT(17), MGAM(14), PFKL(1), PFKM(8), PFKP(6), PGM1(5), PGM3(2), RDH11(3), RDH12(2), RDH13(2), RDH14(2), UGP2(4) 54230601 114 86 111 32 12 21 23 35 23 0 0.407 1.000 1.000 448 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(7), ACAA1(1), ACAA2(2), ACADS(2), ACAT1(2), ALDH1A3(6), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(3), ALDH6A1(1), ALDH9A1(1), AOX1(7), AUH(1), BCAT1(4), BCAT2(5), BCKDHA(4), BCKDHB(1), DBT(1), DLD(1), EHHADH(4), HADH(2), HADHA(2), HADHB(3), HIBADH(2), HIBCH(2), HMGCS1(6), HMGCS2(3), HSD17B10(1), HSD17B4(8), IVD(3), MCCC1(4), MCCC2(1), MUT(3), OXCT1(5), OXCT2(5), PCCA(4), PCCB(2) 62262318 114 86 111 29 20 31 18 24 21 0 0.358 1.000 1.000 449 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 36 ANKHD1(12), EEF1A2(3), EEF1B2(2), EEF1D(1), EEF1G(1), EEF2(5), EEF2K(6), EIF1AX(3), EIF2AK1(5), EIF2AK2(3), EIF2AK3(4), EIF2B1(2), EIF2B2(2), EIF2B3(2), EIF2B4(3), EIF2B5(4), EIF2S1(3), EIF2S2(3), EIF2S3(2), EIF4A1(2), EIF4A2(10), EIF4G1(9), EIF4G3(5), EIF5(2), EIF5B(5), ETF1(3), GSPT2(5), PABPC1(2), PABPC3(8) 63092641 117 85 116 30 21 41 16 16 23 0 0.483 1.000 1.000 450 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 AGMAT(4), ALDH1A1(4), ALDH1A2(1), ALDH1A3(6), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(3), ALDH4A1(3), ALDH9A1(1), AMD1(2), AOC2(6), AOC3(3), ARG1(3), ARG2(2), ASL(4), CKB(1), CKM(1), CKMT1A(1), CKMT1B(1), CKMT2(5), CPS1(12), DAO(1), GAMT(1), GATM(3), GLUD1(2), GOT1(2), GOT2(1), MAOA(2), MAOB(4), NOS1(13), NOS3(3), OAT(2), OTC(3), P4HA1(3), P4HA2(4), P4HA3(3), P4HB(2), RARS(5) 62290750 122 83 121 35 20 29 38 20 15 0 0.381 1.000 1.000 451 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 50 AKR1C3(1), ALOX12(7), ALOX12B(1), ALOX15(4), ALOX15B(5), ALOX5(3), CBR1(3), CYP2B6(5), CYP2C18(2), CYP2C19(6), CYP2C8(3), CYP2C9(3), CYP2E1(2), CYP2U1(1), CYP4A11(7), CYP4A22(2), CYP4F2(3), CYP4F3(2), DHRS4(1), EPHX2(2), GGT1(4), GPX2(1), GPX5(1), LTA4H(2), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(2), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(1), PTGDS(2), PTGES2(2), PTGIS(4), PTGS1(5), PTGS2(6), TBXAS1(3) 55464863 112 83 112 29 16 30 27 23 16 0 0.156 1.000 1.000 452 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(8), ACTG2(4), ADCY3(5), ADCY9(14), AK1(1), ARF1(2), ATP6V0A1(5), ATP6V0A2(3), ATP6V0A4(4), ATP6V0B(2), ATP6V0C(1), ATP6V0D2(2), ATP6V0E1(2), ATP6V1A(4), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1E2(2), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), ERO1L(3), GNAS(11), PDIA4(7), PLCG1(8), PLCG2(8), PRKCA(4), SEC61A1(4), SEC61A2(3), TRIM23(4) 53014253 122 83 121 31 23 35 19 19 26 0 0.274 1.000 1.000 453 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(3), AGTR2(2), CALM2(1), CAMK2A(3), CAMK2B(2), CAMK2D(4), CAMK2G(2), CDK5(2), F2(2), GNA11(3), GNAI1(2), GNB1(2), HRAS(2), JAK2(7), MAP2K1(5), MAP2K2(2), MAPK1(1), MAPK14(1), MAPK3(1), MAPK8(2), MAPT(3), MYLK(11), PLCG1(8), PRKCA(4), PTK2B(6), RAF1(4), SHC1(2), SOS1(5), STAT1(4), STAT3(5), STAT5A(6), SYT1(1) 59913509 108 82 108 36 18 30 16 22 22 0 0.760 1.000 1.000 454 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 AGXT(1), AGXT2(2), AKR1B10(1), ALAS1(5), ALAS2(7), AMT(1), AOC2(6), AOC3(3), BHMT(1), CBS(1), CHKA(1), CHKB(4), CTH(3), DAO(1), DLD(1), DMGDH(7), GAMT(1), GARS(2), GATM(3), GCAT(3), GLDC(8), HSD3B7(1), MAOA(2), MAOB(4), PEMT(1), PHGDH(1), PIPOX(2), PSAT1(1), PSPH(1), RDH11(3), RDH12(2), RDH13(2), RDH14(2), SARDH(5), SARS(4), SARS2(2), SHMT1(1), SHMT2(3), TARS(8), TARS2(9) 61084948 116 82 116 41 12 28 21 35 20 0 0.825 1.000 1.000 455 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 28 ARSB(3), FUCA1(1), FUCA2(3), GALNS(2), GBA(2), GLB1(4), GNS(2), GUSB(6), HEXA(3), HEXB(3), HGSNAT(6), HPSE(6), HPSE2(5), HYAL2(3), IDS(2), IDUA(1), LCT(17), MAN2B1(6), MAN2B2(6), MAN2C1(6), MANBA(5), NAGLU(1), NEU1(1), NEU3(2), SPAM1(4) 46846410 100 82 101 33 16 30 16 20 18 0 0.709 1.000 1.000 456 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 AGXT(1), AGXT2(2), ALAS1(5), ALAS2(7), AMT(1), AOC2(6), AOC3(3), ATP6V0C(1), BHMT(1), CBS(1), CHKA(1), CHKB(4), CPT1B(4), CTH(3), DAO(1), DLD(1), DMGDH(7), GAMT(1), GARS(2), GATM(3), GCAT(3), GLDC(8), MAOA(2), MAOB(4), PEMT(1), PLCB2(7), PLCG1(8), PLCG2(8), PSPH(1), SARDH(5), SARS(4), SHMT1(1), SHMT2(3), TARS(8) 59912989 118 81 118 45 18 24 20 32 23 1 0.938 1.000 1.000 457 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 38 ANAPC1(9), ANAPC10(1), ANAPC11(1), ANAPC4(4), ANAPC5(5), ANAPC7(4), BTRC(4), CDC16(3), CDC20(1), CDC23(1), CUL1(2), CUL2(4), CUL3(4), FBXW7(15), ITCH(4), SKP1(1), SKP2(2), SMURF1(3), SMURF2(5), TCEB1(1), UBA1(8), UBE2D1(1), UBE2D2(3), UBE2D3(2), UBE2E1(1), UBE2E3(1), WWP1(6), WWP2(12) 55931775 108 81 103 27 18 39 16 20 14 1 0.490 1.000 1.000 458 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(3), CAMK2B(2), CAMK2D(4), CAMK2G(2), DAG1(2), ITPKA(1), ITPKB(8), ITPR1(15), ITPR2(18), ITPR3(14), NFAT5(7), PDE6A(7), PDE6B(3), PDE6C(7), SLC6A13(3), TF(5) 51487665 101 81 100 34 14 30 15 27 15 0 0.789 1.000 1.000 459 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(5), CALM2(1), CREB1(1), ELK1(4), GNAI1(2), GNAQ(1), GNAS(11), GNB1(2), HRAS(2), JUN(3), MAP2K1(5), MAPK3(1), NFATC1(5), NFATC2(4), NFATC3(7), NFATC4(6), PLCG1(8), PPP3CA(5), PPP3CB(2), PRKACB(1), PRKACG(3), PRKAR1A(4), PRKAR2A(2), PRKAR2B(2), PRKCA(4), RAF1(4), RPS6KA3(8), SYT1(1) 47348095 104 80 104 38 26 27 14 18 19 0 0.905 1.000 1.000 460 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 40 ACY3(3), ALDH1A3(6), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(3), ALDH3B2(4), ALDH9A1(1), AMDHD1(4), AOC2(6), AOC3(3), ASPA(4), CARM1(4), CNDP1(7), DDC(3), HAL(7), HARS(2), HEMK1(2), HNMT(2), LCMT1(1), LCMT2(10), MAOA(2), MAOB(4), METTL2B(4), PRMT2(2), PRMT3(3), PRMT5(5), PRMT6(2), PRMT7(3), PRMT8(4), PRPS2(1), UROC1(4), WBSCR22(2) 54757353 113 80 112 27 18 30 26 13 25 1 0.201 1.000 1.000 461 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(2), ALG10(3), ALG10B(5), ALG11(1), ALG12(3), ALG13(5), ALG14(1), ALG2(2), ALG3(1), ALG5(5), ALG6(2), ALG8(1), ALG9(2), B4GALT1(3), B4GALT3(2), DAD1(1), DDOST(2), DHDDS(3), DOLPP1(2), DPAGT1(3), DPM1(4), FUT8(3), GANAB(10), MAN1A1(6), MAN1A2(2), MAN1B1(3), MAN2A1(6), MGAT3(4), MGAT4A(3), MGAT4B(4), MGAT5(3), MGAT5B(8), RPN1(4), RPN2(2), ST6GAL1(3), STT3B(3) 59309899 117 79 117 35 12 31 28 23 22 1 0.632 1.000 1.000 462 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAS1(5), ALAS2(7), BLVRA(4), BLVRB(1), COX10(7), COX15(3), CP(7), EARS2(3), EPRS(11), FTMT(2), GUSB(6), HCCS(1), HMBS(3), HMOX2(1), MMAB(1), PPOX(5), UGT1A1(6), UGT1A10(3), UGT1A3(3), UGT1A4(2), UGT1A6(4), UGT1A7(3), UGT1A9(2), UGT2A1(4), UGT2B10(3), UGT2B11(1), UGT2B15(5), UGT2B17(2), UGT2B28(3), UGT2B4(3), UGT2B7(3), UROD(2), UROS(2) 59796273 118 78 117 42 9 36 20 35 17 1 0.936 1.000 1.000 463 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(3), CAPN1(8), CAPN2(8), CXCR3(6), EGF(5), EGFR(5), HRAS(2), ITGA1(6), ITGB1(5), MAPK1(1), MAPK3(1), MYLK(11), PRKACB(1), PRKACG(3), PRKAR1A(4), PRKAR2A(2), PRKAR2B(2), PTK2(7), TLN1(15) 47804254 95 77 94 34 19 23 21 17 14 1 0.824 1.000 1.000 464 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(2), B4GALT1(3), G6PC(2), GAA(2), GALK2(3), GALT(1), GANAB(10), GCK(3), GLA(5), GLB1(4), HK1(3), HK2(5), HK3(5), LALBA(1), LCT(17), MGAM(14), PFKM(8), PFKP(6), PGM1(5), PGM3(2) 46025028 101 76 98 28 13 18 22 28 20 0 0.402 1.000 1.000 465 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 41 ACACA(12), ACACB(10), ACAT1(2), ACOT12(1), ACSS1(1), ACSS2(2), ACYP1(2), AKR1B1(2), ALDH1A3(6), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(3), ALDH9A1(1), DLAT(2), DLD(1), GRHPR(2), LDHA(2), LDHC(4), MDH1(1), ME2(2), ME3(4), PC(10), PCK1(5), PCK2(4), PDHA1(3), PDHA2(4), PDHB(1), PKLR(5) 66013581 97 76 96 33 21 24 20 18 14 0 0.697 1.000 1.000 466 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 58 A4GALT(1), B3GALNT1(1), B3GALT1(3), B3GALT2(2), B3GALT4(2), B3GALT5(2), B3GNT1(1), B3GNT2(2), B3GNT3(1), B3GNT4(1), B3GNT5(4), B4GALT1(3), B4GALT3(2), B4GALT4(2), B4GALT6(2), FUT1(1), FUT3(3), FUT5(2), FUT6(3), GBGT1(2), GCNT2(1), PIGA(5), PIGB(2), PIGG(6), PIGL(1), PIGM(3), PIGN(4), PIGO(3), PIGQ(3), PIGS(2), PIGT(4), PIGV(2), PIGZ(3), ST3GAL1(2), ST3GAL2(2), ST3GAL3(4), ST3GAL4(2), ST3GAL5(2), ST6GALNAC3(4), ST6GALNAC4(1), ST6GALNAC5(2), ST6GALNAC6(1), ST8SIA1(1), UGCG(1) 67007294 101 76 101 33 14 27 27 21 12 0 0.615 1.000 1.000 467 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 EGFR(5), ELK1(4), GNAS(11), GNB1(2), HRAS(2), IGF1R(7), ITGB1(5), KLK2(3), MAP2K1(5), MAP2K2(2), MAPK1(1), MAPK3(1), MKNK1(2), MKNK2(4), MYC(1), NGFR(1), PDGFRA(6), PPP2CA(3), PTPRR(4), RAF1(4), RPS6KA1(6), RPS6KA5(4), SHC1(2), SOS1(5), SRC(1), STAT3(5) 46623727 96 75 94 24 19 26 11 26 14 0 0.332 1.000 1.000 468 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 APC(23), ATF2(4), AXIN1(5), BMP10(1), BMP2(3), BMP4(2), BMP5(4), BMPR1A(1), BMPR2(8), CHRD(5), CTNNB1(2), DVL1(2), FZD1(3), GATA4(2), GSK3B(2), MAP3K7(3), MEF2C(4), NKX2-5(1), NOG(1), NPPA(1), RFC1(7), TGFB1(2), TGFB2(1), TGFB3(1), TGFBR1(4), TGFBR2(4), TGFBR3(4) 50609216 100 72 99 30 13 26 13 28 18 2 0.746 1.000 1.000 469 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(3), ATP4B(3), ATP5O(2), ATP6AP1(2), ATP6V0A1(5), ATP6V0A4(4), ATP6V0B(2), ATP6V0C(1), ATP6V1A(4), ATP6V1B1(4), ATP6V1B2(3), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), ATP7A(13), ATP7B(6), COX10(7), COX5A(1), COX5B(1), COX6A1(1), COX6C(1), COX7A2(1), NDUFA1(2), NDUFA10(1), NDUFA4(1), NDUFB5(3), NDUFB6(2), NDUFS1(1), NDUFS2(7), NDUFV1(5), NDUFV2(1), PPA2(2), SDHB(2), SHMT1(1), UQCRB(1), UQCRC1(1), UQCRFS1(1) 55743348 106 72 106 37 21 33 15 20 17 0 0.822 1.000 1.000 470 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 35 ARSA(2), ARSE(4), ASAH1(1), B4GALT6(2), CERK(2), DEGS1(4), DEGS2(1), ENPP7(5), GAL3ST1(5), GALC(1), GBA(2), GLA(5), GLB1(4), LCT(17), NEU1(1), NEU3(2), PPAP2A(2), PPAP2C(1), SGMS1(2), SGMS2(2), SGPP1(2), SGPP2(1), SMPD1(2), SMPD3(1), SMPD4(2), SPHK1(1), SPHK2(2), SPTLC1(4), SPTLC2(6), UGCG(1), UGT8(5) 47142244 92 71 90 26 18 26 14 22 12 0 0.419 1.000 1.000 471 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(2), AKR1B10(1), ALDOA(5), ALDOB(3), ALDOC(2), FBP1(2), FPGT(1), FUK(4), GMDS(2), GMPPA(1), HK1(3), HK2(5), HK3(5), HSD3B7(1), KHK(4), MPI(2), MTMR1(1), MTMR2(2), MTMR6(3), PFKFB2(1), PFKFB3(4), PFKFB4(3), PFKL(1), PFKM(8), PFKP(6), PGM2(5), PMM1(2), RDH11(3), RDH12(2), RDH13(2), RDH14(2), SORD(2), TPI1(2), TSTA3(2) 53080385 94 69 92 31 14 19 14 25 22 0 0.734 1.000 1.000 472 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AASDH(6), AASDHPPT(4), AASS(5), ACAT1(2), ALDH1A1(4), ALDH1A2(1), ALDH1A3(6), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(3), ALDH9A1(1), ATP6V0C(1), BBOX1(2), DLST(3), DOT1L(8), EHHADH(4), EHMT1(9), EHMT2(5), GCDH(2), HADHA(2), PLOD1(2), PLOD2(2), PLOD3(5), SHMT1(1), SHMT2(3), TMLHE(1) 49170055 87 69 86 40 10 19 21 18 19 0 0.995 1.000 1.000 473 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 B4GALT5(4), C1GALT1(3), C1GALT1C1(3), GALNT1(3), GALNT10(5), GALNT11(5), GALNT12(2), GALNT13(6), GALNT14(1), GALNT2(2), GALNT3(3), GALNT4(1), GALNT5(6), GALNT6(3), GALNT7(4), GALNT8(5), GALNT9(5), GALNTL5(7), GCNT3(1), GCNT4(3), OGT(5), ST3GAL1(2), ST3GAL2(2), ST6GALNAC1(5), WBSCR17(7) 46750268 93 68 93 37 15 23 14 26 13 2 0.959 1.000 1.000 474 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2A1(2), GTF2A1L(2), GTF2E1(2), GTF2E2(3), GTF2F1(1), GTF2F2(1), GTF2H1(2), GTF2H3(2), GTF2I(4), GTF2IRD1(1), STON1(5), TAF1(14), TAF13(1), TAF1L(19), TAF2(6), TAF4(3), TAF4B(6), TAF5(4), TAF5L(5), TAF6(3), TAF6L(2), TAF7(1), TAF7L(6), TAF9(1), TBPL2(2) 50925521 98 68 97 23 18 31 15 17 17 0 0.296 1.000 1.000 475 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 23 POLA1(15), POLA2(5), POLB(1), POLD1(5), POLD2(1), POLE(10), POLE2(2), POLE3(1), POLG(7), POLG2(2), POLH(3), POLI(2), POLK(2), POLL(2), POLM(3), POLQ(12), PRIM1(1), REV1(6), REV3L(17), RFC5(1) 58375671 98 68 96 26 10 23 21 24 19 1 0.650 1.000 1.000 476 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 36 ACACA(12), ACAT1(2), ACYP1(2), ADH5(5), AKR1B1(2), ALDH1A1(4), ALDH1A2(1), ALDH1A3(6), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(3), ALDH9A1(1), DLAT(2), DLD(1), GRHPR(2), LDHA(2), LDHC(4), MDH1(1), ME2(2), ME3(4), PC(10), PCK1(5), PDHA1(3), PDHA2(4), PDHB(1), PKLR(5) 52005884 89 67 88 28 16 25 18 15 15 0 0.600 1.000 1.000 477 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 38 ARNTL(2), AZIN1(3), CBX3(1), CLOCK(3), CRY1(2), CRY2(3), DNAJA1(2), EIF4G2(2), ETV6(4), GSTP1(1), HSPA8(6), IDI1(5), MYF6(5), NCKAP1(9), NR1D2(2), PER1(9), PER2(8), PPP1R3C(3), PPP2CB(2), SF3A3(1), TOB1(2), TUBB3(2), UCP3(2), UGP2(4), VAPA(2), ZFR(7) 51630583 92 66 92 32 13 37 15 12 14 1 0.945 1.000 1.000 478 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1(5), CSF1R(3), DDX20(4), E2F1(5), E2F4(2), ETS1(3), ETS2(7), ETV3(4), HDAC2(2), HDAC5(6), HRAS(2), JUN(3), NCOR2(8), RBL1(6), SIN3A(10), SIN3B(7) 37499800 77 65 77 21 14 21 8 13 21 0 0.663 1.000 1.000 479 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(5), ADRBK2(1), ARRB2(1), CALM2(1), CALML6(1), CAMK2A(3), CAMK2B(2), CAMK2D(4), CAMK2G(2), CLCA1(6), CLCA2(5), CLCA4(4), CNGA3(4), CNGA4(5), CNGB1(4), GUCA1A(1), GUCA1B(1), GUCA1C(4), PDC(1), PDE1C(5), PRKACA(3), PRKACB(1), PRKACG(3), PRKG1(4), PRKG2(7), PRKX(5) 44151063 83 65 82 41 12 21 15 22 13 0 0.997 1.000 1.000 480 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(2), AP2A1(6), AP2M1(1), ARF1(2), BAD(1), BTK(7), EEA1(10), GRASP(2), GSK3A(5), GSK3B(2), LYN(6), PDPK1(2), PFKL(1), PFKM(8), PFKP(6), PLCG1(8), PRKCE(8), PRKCZ(2), RPS6KB1(4), VAV2(3) 35611850 86 65 84 31 17 19 12 19 19 0 0.907 1.000 1.000 481 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(3), ACTN1(5), ACTN2(10), CAPN1(8), ITGA1(6), ITGB1(5), ITGB3(4), PTK2(7), SPTAN1(12), SRC(1), TLN1(15) 41420721 76 65 76 25 17 16 12 16 14 1 0.793 1.000 1.000 482 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 37 ACAA1(1), ACAA2(2), ACAD8(1), ACAD9(4), ADH1A(1), ADH4(1), ADH5(5), ADH6(2), ADH7(3), ADHFE1(2), AKR1B10(1), AKR1C4(3), AKR1D1(1), ALDH1A3(6), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(3), ALDH9A1(1), BAAT(5), CEL(4), CYP27A1(1), CYP7A1(3), HADHB(3), HSD3B7(1), LIPA(3), RDH11(3), RDH12(2), RDH13(2), RDH14(2), SLC27A5(4), SOAT1(2), SOAT2(2), SRD5A1(4) 44833176 83 64 82 28 13 15 23 14 18 0 0.698 1.000 1.000 483 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(23), AXIN1(5), CREBBP(15), CTNNB1(2), DVL1(2), EP300(13), FZD1(3), GSK3B(2), HDAC1(6), LDB1(1), PITX2(5), TRRAP(12) 46576853 89 64 89 32 13 17 14 25 18 2 0.933 1.000 1.000 484 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(23), AXIN1(5), BTRC(4), CCND1(1), CREBBP(15), CSNK1A1(3), CSNK2A1(3), CTBP1(1), CTNNB1(2), DVL1(2), FZD1(3), GSK3B(2), HDAC1(6), MAP3K7(3), MYC(1), NLK(1), PPARD(2), PPP2CA(3), TLE1(4), WIF1(3) 41401703 87 63 87 26 17 25 9 17 17 2 0.754 1.000 1.000 485 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(8), CARS(4), DARS(3), EPRS(11), FARS2(4), GARS(2), HARS(2), IARS(8), LARS(5), LARS2(3), MARS(9), MARS2(1), NARS(1), QARS(10), RARS(5), SARS(4), TARS(8), WARS2(2), YARS(4) 46252360 94 62 93 26 10 34 12 22 16 0 0.517 1.000 1.000 486 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(7), ACACA(12), ACACB(10), ACAT1(2), ACSS1(1), ACSS2(2), ALDH1A3(6), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(3), ALDH6A1(1), ALDH9A1(1), EHHADH(4), HADHA(2), HIBCH(2), LDHA(2), LDHC(4), MLYCD(4), MUT(3), PCCA(4), PCCB(2), SUCLA2(1), SUCLG2(1) 57188767 79 62 78 33 8 23 16 19 13 0 0.965 1.000 1.000 487 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM2(1), DLG4(1), GRIN1(3), GRIN2A(16), GRIN2B(11), GRIN2C(5), GRIN2D(5), NOS1(13), PPP3CA(5), PPP3CB(2), PRKACB(1), PRKACG(3), PRKAR1A(4), PRKAR2A(2), PRKAR2B(2), PRKCA(4), SYT1(1) 36138763 79 62 79 35 17 21 17 13 11 0 0.938 1.000 1.000 488 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 20 ADCY1(5), CD3E(3), CD3G(3), CD4(4), CREBBP(15), GNAS(11), GNB1(2), HLA-DRB1(10), LCK(2), PRKACB(1), PRKACG(3), PRKAR1A(4), PRKAR2A(2), PRKAR2B(2), PTPRC(8), ZAP70(3) 30964507 78 61 78 29 15 18 17 13 15 0 0.906 1.000 1.000 489 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 20 ADCY1(5), CD3E(3), CD3G(3), CD4(4), CREBBP(15), GNAS(11), GNB1(2), HLA-DRB1(10), LCK(2), PRKACB(1), PRKACG(3), PRKAR1A(4), PRKAR2A(2), PRKAR2B(2), PTPRC(8), ZAP70(3) 30964507 78 61 78 29 15 18 17 13 15 0 0.906 1.000 1.000 490 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA1(1), ACAA2(2), ACADL(1), ACADS(2), ACADSB(4), ACAT1(2), ALDH1A1(4), ALDH1A2(1), ALDH1A3(6), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(3), ALDH6A1(1), ALDH9A1(1), AOX1(7), BCAT1(4), BCKDHA(4), BCKDHB(1), EHHADH(4), HADHA(2), HADHB(3), HIBADH(2), IVD(3), MCCC1(4), MCCC2(1), MUT(3), OXCT1(5), PCCA(4), PCCB(2) 51915745 82 60 81 24 12 19 14 19 18 0 0.639 1.000 1.000 491 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 28 AKR1C4(3), AKR1D1(1), ARSB(3), ARSE(4), CYP11B1(5), CYP11B2(4), HSD11B1(3), HSD11B2(2), HSD17B2(4), HSD17B3(2), HSD3B1(3), HSD3B2(4), SRD5A1(4), STS(1), SULT1E1(3), UGT1A1(6), UGT1A10(3), UGT1A3(3), UGT1A4(2), UGT1A6(4), UGT1A7(3), UGT1A9(2), UGT2B15(5), UGT2B4(3) 38157768 77 59 76 26 7 23 19 19 9 0 0.646 1.000 1.000 492 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP2(1), ACP5(3), ACPP(6), ACPT(1), ALPL(1), ALPP(3), ALPPL2(2), CYP1A1(1), CYP1A2(2), CYP2A13(8), CYP2A6(1), CYP2A7(1), CYP2B6(5), CYP2C18(2), CYP2C19(6), CYP2C8(3), CYP2C9(3), CYP2D6(3), CYP2E1(2), CYP2F1(5), CYP3A4(4), CYP3A5(2), CYP3A7(5), CYP4B1(4), CYP51A1(2), PON1(4) 41449158 80 57 79 26 12 20 13 25 10 0 0.586 1.000 1.000 493 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(8), C5(5), C6(8), C7(8), ICAM1(2), IL1A(1), IL6(1), ITGA4(6), ITGAL(4), ITGB1(5), ITGB2(7), SELP(10), SELPLG(2), VCAM1(7) 35595483 74 57 74 27 8 21 16 20 9 0 0.865 1.000 1.000 494 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 31 ADRA1A(6), ADRA1B(1), ADRA2C(2), ADRB2(2), ADRB3(1), CHRM1(4), CHRM2(6), CHRM3(3), CHRM4(1), DRD1(1), DRD2(3), DRD3(1), DRD5(4), HRH1(4), HRH2(4), HTR1A(4), HTR1B(3), HTR1D(4), HTR1E(4), HTR1F(4), HTR2A(5), HTR2C(5), HTR5A(4) 35177144 76 57 76 33 25 11 11 20 9 0 0.773 1.000 1.000 495 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(7), ACACA(12), ACADL(1), ACADSB(4), ACAT1(2), ALDH1A1(4), ALDH1A2(1), ALDH1A3(6), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(3), ALDH6A1(1), ALDH9A1(1), EHHADH(4), HADHA(2), LDHA(2), LDHC(4), MLYCD(4), MUT(3), PCCA(4), PCCB(2), SUCLA2(1), SUCLG2(1) 47786853 74 57 73 30 5 24 13 17 15 0 0.964 1.000 1.000 496 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 CCNH(2), CDK7(3), ERCC3(4), GTF2E1(2), GTF2E2(3), GTF2F2(1), GTF2H1(2), ILK(3), MNAT1(2), POLR1A(10), POLR1B(4), POLR2A(6), POLR2B(5), POLR2C(1), POLR2F(3), POLR2G(1), POLR2H(1), POLR2J(1), POLR3B(2), POLR3D(2), POLR3E(4), POLR3H(1), POLR3K(1), TAF13(1), TAF5(4), TAF6(3), TAF7(1), TAF9(1), TBP(2) 49412064 76 57 75 31 10 19 12 16 19 0 0.982 1.000 1.000 497 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(7), ACADL(1), ACADSB(4), ALDH1A1(4), ALDH1A2(1), ALDH1A3(6), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(3), ALDH9A1(1), AOC2(6), AOC3(3), CNDP1(7), DPYD(2), DPYS(3), EHHADH(4), GAD1(3), GAD2(3), HADHA(2), MLYCD(4), UPB1(2) 41065561 71 56 70 26 7 19 17 14 14 0 0.867 1.000 1.000 498 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(7), ALDH1A3(6), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(3), ALDH9A1(1), AOC2(6), AOC3(3), CNDP1(7), DPYD(2), DPYS(3), EHHADH(4), GAD1(3), GAD2(3), HADHA(2), HIBCH(2), MLYCD(4), SRM(4), UPB1(2) 37895293 67 56 66 20 7 16 18 13 13 0 0.591 1.000 1.000 499 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(7), DLG4(1), EPHB2(5), F2(2), F2RL1(1), F2RL2(2), JUN(3), MAP2K5(1), MAPK1(1), MAPK7(4), MAPK8(2), MYEF2(3), PLD1(7), PLD2(2), PLD3(2), PTK2(7), RAF1(4), RASAL1(5), SRC(1), TEC(6), VAV1(6) 39256202 72 56 72 20 20 19 11 12 10 0 0.369 1.000 1.000 500 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(4), ABAT(7), ACADS(2), ACAT1(2), ALDH1A1(4), ALDH1A2(1), ALDH1A3(6), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(3), ALDH5A1(2), ALDH9A1(1), EHHADH(4), GAD1(3), GAD2(3), HADHA(2), L2HGDH(2), OXCT1(5), PDHA1(3), PDHA2(4), PDHB(1), SDHB(2) 36754818 66 55 65 23 11 15 13 15 12 0 0.760 1.000 1.000 501 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(1), ALOX15(4), ALOX5(3), CYP1A2(2), CYP2C18(2), CYP2C19(6), CYP2C8(3), CYP2C9(3), CYP2E1(2), CYP3A4(4), CYP3A43(3), CYP3A5(2), CYP3A7(5), HSD3B7(1), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(2), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(1), RDH11(3), RDH12(2), RDH13(2), RDH14(2) 34402529 69 55 69 20 7 19 14 18 11 0 0.478 1.000 1.000 502 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 BLVRA(4), BLVRB(1), CP(7), EPRS(11), GUSB(6), HCCS(1), HMBS(3), HMOX2(1), PPOX(5), UGT1A1(6), UGT1A10(3), UGT1A3(3), UGT1A4(2), UGT1A6(4), UGT1A7(3), UGT1A9(2), UGT2B15(5), UGT2B4(3), UROD(2), UROS(2) 39440600 74 55 73 30 5 23 15 20 10 1 0.963 1.000 1.000 503 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(8), CD2(4), CD33(3), CD5(3), CD7(1), IFNA1(1), IFNG(2), IL12B(2), IL3(1), IL4(1), ITGAX(10), TLR2(3), TLR4(15), TLR7(9), TLR9(2) 26584788 65 54 64 23 7 15 17 13 13 0 0.741 1.000 1.000 504 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(1), CHIA(3), CHIT1(3), CMAS(3), CTBS(1), CYB5R1(4), GFPT1(3), GFPT2(9), GNE(5), GNPDA2(2), GNPNAT1(2), HEXA(3), HEXB(3), HK1(3), HK2(5), HK3(5), MTMR1(1), MTMR2(2), MTMR6(3), NAGK(1), NPL(2), PGM3(2), UAP1(3) 41308047 69 54 68 17 11 22 13 14 9 0 0.340 1.000 1.000 505 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(7), EXT2(6), EXTL1(1), EXTL2(1), EXTL3(6), GLCE(4), HS2ST1(3), HS3ST1(2), HS3ST2(4), HS3ST3A1(1), HS3ST3B1(1), HS3ST5(5), HS6ST1(5), HS6ST2(7), HS6ST3(3), NDST1(4), NDST2(1), NDST3(5) 29037267 66 54 64 20 15 17 3 17 14 0 0.688 1.000 1.000 506 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(11), APOA1(3), APOA4(1), CETP(4), CYP7A1(3), DGAT1(2), HMGCR(4), LCAT(1), LDLR(4), LIPC(2), LPL(1), LRP1(27), SCARB1(4), SOAT1(2) 38209010 69 54 69 24 16 8 17 13 14 1 0.803 1.000 1.000 507 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(8), CALM2(1), CAPN2(8), EP300(13), HDAC1(6), HDAC2(2), MEF2D(3), NFATC1(5), NFATC2(4), PPP3CA(5), PPP3CB(2), PRKCA(4), SYT1(1) 33507887 62 53 62 23 8 15 9 13 17 0 0.933 1.000 1.000 508 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 25 ALDH1A3(6), ALDH3A1(3), ALDH3B2(4), AOC2(6), AOC3(3), DDC(3), EPX(4), ESCO1(4), ESCO2(1), GOT1(2), GOT2(1), HPD(4), LPO(4), MAOA(2), MAOB(4), MPO(5), PNPLA3(3), SH3GLB1(2), TAT(3), TPO(7) 47346097 71 52 70 19 14 16 11 15 14 1 0.483 1.000 1.000 509 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(4), AGT(3), AGTR1(4), AGTR2(2), COL4A1(10), COL4A2(10), COL4A3(6), COL4A4(9), COL4A5(12), COL4A6(10), REN(1) 37378954 71 51 71 20 12 16 15 13 15 0 0.391 1.000 1.000 510 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 17 CALM2(1), CDKN1A(1), GNAQ(1), NFATC1(5), NFATC2(4), NFATC3(7), NFATC4(6), PLCG1(8), PPP3CA(5), PPP3CB(2), PRKCA(4), SP1(6), SP3(7), SYT1(1) 28045254 58 51 57 21 7 16 8 13 14 0 0.895 1.000 1.000 511 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(10), COL4A2(10), COL4A3(6), COL4A4(9), COL4A5(12), COL4A6(10), P4HB(2), SLC23A1(1), SLC23A2(7), SLC2A3(3) 37265734 70 51 70 25 12 15 17 10 16 0 0.790 1.000 1.000 512 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 14 FUCA1(1), FUCA2(3), GLB1(4), HEXA(3), HEXB(3), LCT(17), MAN2B1(6), MAN2B2(6), MAN2C1(6), MANBA(5), NEU1(1), NEU3(2) 26889461 57 50 57 18 8 19 10 10 10 0 0.596 1.000 1.000 513 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT1(1), AGPAT3(2), AGPAT4(2), AGPAT6(3), AGPS(1), CHPT1(4), ENPP2(10), ENPP6(2), PAFAH1B1(3), PAFAH1B3(1), PLA2G12A(2), PLA2G12B(1), PLA2G1B(1), PLA2G2A(1), PLA2G2D(2), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(1), PLD1(7), PLD2(2), PPAP2A(2), PPAP2C(1) 33197621 60 50 60 16 6 18 13 13 10 0 0.394 1.000 1.000 514 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(7), AGT(3), AGTR2(2), EDN1(5), EDNRA(3), EDNRB(2), EGF(5), EGFR(5), HRAS(2), JUN(3), MYC(1), NFKB1(5), PLCG1(8), PRKCA(4), RELA(3) 29232806 58 49 57 20 10 15 6 16 11 0 0.814 1.000 1.000 515 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(4), EGF(5), EGFR(5), HRAS(2), MAP2K1(5), MAPK1(1), MAPK3(1), PTPRB(11), RAF1(4), RASA1(2), SHC1(2), SOS1(5), SPRY1(7), SPRY2(2), SPRY3(6), SRC(1) 36128690 63 49 62 25 14 14 8 18 9 0 0.897 1.000 1.000 516 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 66 MRPL13(2), MRPS7(2), RPL10L(1), RPL12(1), RPL13A(4), RPL18(1), RPL18A(4), RPL19(2), RPL22L1(1), RPL24(1), RPL26(1), RPL3(2), RPL31(1), RPL32(1), RPL35(1), RPL36A(1), RPL37A(1), RPL3L(3), RPL41(1), RPL7(1), RPL8(2), RPL9(1), RPS10(1), RPS12(1), RPS16(1), RPS18(1), RPS2(1), RPS25(1), RPS29(1), RPS5(6), RPS6(4), RPS8(1) 32180945 53 48 53 17 12 12 12 11 6 0 0.715 1.000 1.000 517 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 26 ACAA1(1), ACAA2(2), ADH1A(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(2), AKR1C4(3), AKR1D1(1), ALDH1A1(4), ALDH1A2(1), ALDH1A3(6), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(3), ALDH9A1(1), BAAT(5), CEL(4), CYP27A1(1), CYP7A1(3), HADHB(3), SOAT2(2), SRD5A1(4) 32771223 58 47 57 25 10 10 17 7 14 0 0.931 1.000 1.000 518 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 12 ACTN1(5), ACTN2(10), BCAR1(6), CTNNA1(7), CTNNA2(14), CTNNB1(2), PTK2(7), SRC(1), VCL(6) 27071688 58 47 57 19 15 11 4 13 14 1 0.729 1.000 1.000 519 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1QA(1), C1QB(1), C1R(6), C1S(1), C2(3), C3(8), C5(5), C6(8), C7(8), C8A(2), C9(5), MASP1(4), MASP2(2), MBL2(2) 30356054 56 46 56 16 7 16 13 9 11 0 0.646 1.000 1.000 520 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(3), AMD1(2), BHMT(1), CBS(1), CTH(3), DNMT1(8), DNMT3A(8), DNMT3B(3), MARS(9), MARS2(1), MAT1A(2), MAT2B(2), MTAP(1), MTR(5), SRM(4), TAT(3) 29405651 56 46 55 17 10 13 13 10 9 1 0.564 1.000 1.000 521 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(12), ARHGEF1(10), GNA12(2), GNA13(1), GNAQ(1), GNB1(2), MYLK(11), PLCB1(12), PPP1R12B(4), PRKCA(4), ROCK1(8) 29905414 67 46 67 17 9 10 14 12 22 0 0.515 1.000 1.000 522 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(24), MAP2(17), PPP2CA(3), PRKACB(1), PRKACG(3), PRKAG1(2), PRKAR2A(2), PRKAR2B(2), PRKCE(8) 26168027 62 45 62 19 7 23 9 11 11 1 0.867 1.000 1.000 523 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 23 ALDH1A1(4), ALDH1A2(1), ALDH1A3(6), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(3), ALDH3B2(4), ALDH9A1(1), AOC2(6), AOC3(3), ASPA(4), CNDP1(7), DDC(3), HAL(7), HARS(2), HNMT(2), MAOA(2), MAOB(4), PRPS2(1) 33834606 65 45 64 20 11 13 15 10 16 0 0.589 1.000 1.000 524 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 34 BET1(1), BNIP1(1), GOSR1(2), SNAP23(2), SNAP25(3), SNAP29(1), STX10(2), STX11(2), STX12(1), STX16(1), STX17(3), STX19(3), STX2(2), STX3(3), STX4(2), STX6(4), STX8(1), TSNARE1(4), USE1(2), VAMP1(1), VAMP2(1), VAMP3(2), VAMP4(1), VAMP5(1), VAMP7(2), VTI1A(1), VTI1B(2) 23423311 51 45 51 14 8 19 8 6 10 0 0.505 1.000 1.000 525 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(6), AP2A1(6), AP2M1(1), BIN1(2), CALM2(1), DNM1(6), EPN1(3), EPS15(6), PICALM(3), PPP3CA(5), PPP3CB(2), SYNJ1(3), SYNJ2(3), SYT1(1) 32308285 48 45 48 24 9 13 12 6 8 0 0.987 1.000 1.000 526 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(4), CREB1(1), CREBBP(15), EP300(13), NCOA3(10), PRKACB(1), PRKACG(3), PRKAR1A(4), PRKAR2A(2), PRKAR2B(2), RARA(1), RXRA(2) 29330246 58 44 58 22 9 16 10 10 13 0 0.926 1.000 1.000 527 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(3), EPHA4(5), EPHB1(12), ITGA1(6), ITGB1(5), L1CAM(10), LYN(6), RAP1B(1), SELP(10) 22820566 58 44 58 22 15 10 12 16 4 1 0.850 1.000 1.000 528 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 22 POLR1A(10), POLR1B(4), POLR1C(2), POLR1D(4), POLR2A(6), POLR2B(5), POLR2C(1), POLR2D(1), POLR2F(3), POLR2G(1), POLR2H(1), POLR2J(1), POLR3A(5), POLR3B(2), POLR3GL(4), POLR3H(1), POLR3K(1) 33367709 52 44 52 23 9 12 5 12 14 0 0.984 1.000 1.000 529 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(10), AMT(1), ATIC(3), ATP6V0C(1), GART(3), MTHFD1(9), MTHFD1L(5), MTHFR(6), MTHFS(2), MTR(5), SHMT1(1), SHMT2(3), TYMS(1) 25970247 50 44 49 17 4 17 9 6 14 0 0.794 1.000 1.000 530 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 APC(23), AXIN1(5), BTRC(4), CTNNB1(2), DLL1(5), DVL1(2), FZD1(3), GSK3B(2), NOTCH1(8), PSEN1(2) 27714750 56 44 56 19 7 15 11 13 8 2 0.896 1.000 1.000 531 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(8), DYRK1B(1), GLI2(12), GLI3(11), GSK3B(2), PRKACB(1), PRKACG(3), PRKAR1A(4), PRKAR2A(2), PRKAR2B(2), SHH(1), SMO(5), SUFU(3) 21796902 55 44 55 18 11 18 10 8 8 0 0.626 1.000 1.000 532 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1QA(1), C1QB(1), C1R(6), C1S(1), C2(3), C3(8), C5(5), C6(8), C7(8), C8A(2), C8B(3), C9(5), MASP1(4) 29518673 55 43 55 15 6 17 13 8 11 0 0.605 1.000 1.000 533 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 AKR1B1(2), GUSB(6), UGDH(1), UGP2(4), UGT1A1(6), UGT1A10(3), UGT1A3(3), UGT1A4(2), UGT1A6(4), UGT1A7(3), UGT1A9(2), UGT2A1(4), UGT2B10(3), UGT2B11(1), UGT2B15(5), UGT2B17(2), UGT2B28(3), UGT2B4(3), UGT2B7(3), XYLB(2) 38241631 62 43 62 27 3 20 10 20 9 0 0.977 1.000 1.000 534 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(10), AMT(1), ATIC(3), GART(3), MTHFD1(9), MTHFD1L(5), MTHFR(6), MTHFS(2), MTR(5), SHMT1(1), SHMT2(3), TYMS(1) 27306571 49 43 48 17 3 17 9 6 14 0 0.834 1.000 1.000 535 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 21 AOX1(7), BST1(2), CD38(3), ENPP1(7), ENPP3(5), NADK(1), NADSYN1(2), NMNAT1(2), NMNAT2(3), NNT(6), NT5C1A(2), NT5C1B(4), NT5C2(2), NT5E(4), NUDT12(2), QPRT(1) 30248575 53 43 53 21 5 15 7 17 9 0 0.928 1.000 1.000 536 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(8), ABCC2(7), ABCG2(1), BCHE(6), CES1(4), CES2(2), CYP3A4(4), CYP3A5(2), UGT1A1(6), UGT1A10(3), UGT1A3(3), UGT1A4(2), UGT1A6(4), UGT1A7(3), UGT1A9(2) 33210071 57 43 57 27 5 13 11 21 7 0 0.967 1.000 1.000 537 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 10 CD44(3), ICAM1(2), ITGA4(6), ITGAL(4), ITGAM(6), ITGB1(5), ITGB2(7), SELE(2), SELL(6), SELP(10) 23582555 51 43 51 20 5 11 11 14 10 0 0.915 1.000 1.000 538 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CALM2(1), CAMK1(1), CAMK1G(5), CAMK2A(3), CAMK2B(2), CAMK2D(4), CAMK2G(2), CAMK4(5), HDAC5(6), MEF2A(6), MEF2C(4), MEF2D(3), PPARA(4), PPP3CA(5), PPP3CB(2), SLC2A4(1), SYT1(1) 29850433 55 43 55 20 4 16 8 17 10 0 0.850 1.000 1.000 539 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 9 CR1(12), CR2(5), HLA-DRB1(10), ICAM1(2), ITGAL(4), ITGB2(7), PTPRC(8) 21088677 48 42 48 24 3 16 12 10 6 1 0.983 1.000 1.000 540 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(4), F13A1(5), F2(2), F2R(4), FGA(7), FGB(1), FGG(7), PLAT(6), PLG(7), SERPINB2(1), SERPINE1(5) 19628684 49 42 49 19 5 12 10 12 10 0 0.913 1.000 1.000 541 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(4), BCAT2(5), COASY(4), DPYD(2), DPYS(3), ENPP1(7), ENPP3(5), ILVBL(5), PANK1(2), PANK2(1), PANK4(5), UPB1(2), VNN1(3) 24239723 48 42 48 18 8 10 10 11 9 0 0.867 1.000 1.000 542 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(3), ALDH1A3(6), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(3), ALDH9A1(1), CYP2C19(6), CYP2C9(3), DHRS2(4), DHRS3(1), DHRS7(1), EHHADH(4), ESCO1(4), ESCO2(1), HADHA(2), PNPLA3(3), SH3GLB1(2), YOD1(1) 44048137 50 42 49 17 8 12 9 13 7 1 0.797 1.000 1.000 543 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(3), ACTR2(2), ACTR3(2), ARPC1A(3), ARPC1B(2), ARPC2(5), NCK1(2), NCKAP1(9), NTRK1(8), PIR(2), PSMA7(1), WASF1(6), WASF2(3), WASF3(5), WASL(4) 22194844 57 41 57 18 6 22 11 6 11 1 0.785 1.000 1.000 544 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 CARM1(4), DHRS2(4), DHRS3(1), DHRS7(1), HEMK1(2), LCMT1(1), LCMT2(10), METTL2B(4), PRMT2(2), PRMT3(3), PRMT5(5), PRMT6(2), PRMT7(3), PRMT8(4), WBSCR22(2) 20795371 48 41 48 16 5 18 11 6 7 1 0.719 1.000 1.000 545 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOA(5), ALDOB(3), ALDOC(2), FBP1(2), GOT1(2), GOT2(1), GPT(2), GPT2(3), MDH1(1), ME2(2), ME3(4), PGK1(7), PKLR(5), TKT(3), TPI1(2) 25442444 44 40 44 14 9 16 6 7 6 0 0.464 1.000 1.000 546 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(4), GTF2A1(2), GTF2E1(2), GTF2F1(1), HDAC3(1), NCOA1(5), NCOA2(5), NCOA3(10), NCOR2(8), POLR2A(6), RARA(1), RXRA(2), TBP(2) 35597057 49 40 49 29 5 9 10 13 12 0 1.000 1.000 1.000 547 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1QA(1), C1QB(1), C1R(6), C1S(1), C2(3), C3(8), C5(5), C6(8), C7(8), C8A(2), C9(5) 24715528 48 39 48 13 6 15 11 6 10 0 0.605 1.000 1.000 548 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(6), GABARAP(1), GABRA1(4), GABRA2(3), GABRA3(6), GABRA4(7), GABRA5(4), GABRA6(5), GPHN(5), NSF(2), SRC(1), UBQLN1(2) 17332649 46 39 46 14 8 16 10 8 4 0 0.554 1.000 1.000 549 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(4), BCAT2(5), IARS(8), IARS2(5), ILVBL(5), LARS(5), LARS2(3), PDHA1(3), PDHA2(4), PDHB(1), VARS(2), VARS2(1) 22951995 46 39 46 13 8 13 9 8 8 0 0.536 1.000 1.000 550 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARF1(2), ARFGAP1(3), ARFGAP3(1), ARFGEF2(9), COPA(8), GBF1(8), GPLD1(5), KDELR1(2), KDELR2(1), KDELR3(2) 23466812 41 38 41 12 6 17 6 5 5 2 0.552 1.000 1.000 551 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(9), ABCB11(13), ABCB4(10), ABCC1(8), ABCC3(8), GSTP1(1) 21341781 49 38 49 23 7 12 11 10 9 0 0.926 1.000 1.000 552 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(3), GALNT10(5), GALNT2(2), GALNT3(3), GALNT4(1), GALNT6(3), GALNT7(4), GALNT8(5), GALNT9(5), ST3GAL1(2), ST3GAL2(2), ST3GAL4(2), WBSCR17(7) 21154623 44 38 44 16 9 6 8 14 6 1 0.828 1.000 1.000 553 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(15), EP300(13), LPL(1), NCOA1(5), NCOA2(5), PPARG(5), RXRA(2) 26480845 46 38 45 18 9 8 9 9 11 0 0.948 1.000 1.000 554 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(4), CSF1R(3), EGF(5), EGFR(5), MET(10), PDGFRA(6), PRKCA(4), SH3GLB1(2), SH3GLB2(1), SH3KBP1(8), SRC(1) 28209889 49 37 48 24 9 13 6 14 7 0 0.989 1.000 1.000 555 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(4), ASPH(7), CREB1(1), EDN1(5), EP300(13), EPO(1), HIF1A(4), JUN(3), LDHA(2), NOS3(3), P4HB(2) 24048374 45 37 45 12 4 12 8 10 11 0 0.712 1.000 1.000 556 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(2), JAK1(11), PTPRU(10), REG1A(1), STAT1(4), STAT2(5), TYK2(7) 17667029 40 37 38 13 6 5 11 8 10 0 0.767 1.000 1.000 557 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(11), ACE2(4), AGT(3), AGTR1(4), AGTR2(2), ANPEP(8), CPA3(1), CTSA(3), CTSG(1), ENPEP(9), LNPEP(2), MAS1(2), MME(1), NLN(1), REN(1), THOP1(1) 30097506 54 36 54 15 8 16 7 15 8 0 0.501 1.000 1.000 558 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(2), CLOCK(3), CRY1(2), CRY2(3), CSNK1E(4), NPAS2(5), NR1D1(5), PER1(9), PER2(8), PER3(9) 23726746 50 36 50 20 11 11 7 12 9 0 0.955 1.000 1.000 559 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 28 CD4(4), CSF1(5), CSF3(2), HLA-DRB1(10), IFNA1(1), IFNG(2), IL11(1), IL12B(2), IL15(3), IL1A(1), IL3(1), IL4(1), IL6(1), IL7(1), LTA(2), TGFB1(2), TGFB2(1), TGFB3(1) 17969125 41 36 41 16 5 8 10 11 7 0 0.871 1.000 1.000 560 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(3), BHMT(1), CBS(1), CTH(3), DNMT1(8), DNMT3A(8), DNMT3B(3), MARS(9), MARS2(1), MAT1A(2), MAT2B(2), MTR(5) 24760845 46 36 45 16 9 11 9 9 7 1 0.716 1.000 1.000 561 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(12), ACACB(10), FASN(14), MCAT(2), OLAH(1), OXSM(3) 21698172 42 35 42 17 7 12 7 8 8 0 0.883 1.000 1.000 562 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(5), ATP6V0C(1), CAT(2), EPX(4), LPO(4), MPO(5), PRDX1(3), PRDX2(1), PRDX5(4), SHMT1(1), SHMT2(3), TPO(7) 16857361 40 35 40 12 10 9 5 8 8 0 0.546 1.000 1.000 563 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CDK5(2), CDK5R1(1), DRD1(1), DRD2(3), GRM1(9), PLCB1(12), PPP2CA(3), PPP3CA(5), PRKACB(1), PRKACG(3), PRKAR1A(4), PRKAR2A(2), PRKAR2B(2) 22615585 48 34 48 14 7 17 7 8 9 0 0.462 1.000 1.000 564 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(3), CYP51A1(2), DHCR24(4), DHCR7(1), EBP(1), FDFT1(4), FDPS(5), GGCX(3), GGPS1(2), HMGCR(4), IDI1(5), IDI2(1), LSS(2), NQO1(1), NSDHL(3), PMVK(2), SQLE(2) 27394456 45 34 44 22 7 16 5 12 5 0 0.979 1.000 1.000 565 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(7), CD38(3), ENPP1(7), ENPP3(5), NADSYN1(2), NMNAT1(2), NMNAT2(3), NNT(6), NT5E(4), QPRT(1) 20939180 40 34 40 18 3 13 6 11 7 0 0.956 1.000 1.000 566 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(5), GNAS(11), GNB1(2), PPP2CA(3), PRKAA1(3), PRKAA2(2), PRKAB1(1), PRKAB2(1), PRKACB(1), PRKACG(3), PRKAG1(2), PRKAG2(2), PRKAR1A(4), PRKAR2A(2), PRKAR2B(2) 21157763 44 33 44 17 11 10 7 8 8 0 0.925 1.000 1.000 567 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(1), POLD1(5), POLD2(1), POLE(10), POLG(7), POLL(2), POLQ(12) 23714375 38 33 37 12 6 7 6 9 9 1 0.798 1.000 1.000 568 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(4), GABRA2(3), GABRA3(6), GABRA4(7), GABRA5(4), GABRA6(5), PRKCE(8), SOD1(1) 11343299 38 33 38 15 5 12 10 7 4 0 0.865 1.000 1.000 569 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 15 B3GAT1(1), B3GAT2(1), B3GAT3(2), B4GALT7(1), CHPF(2), CHST11(1), CHST3(1), CHST7(1), CHSY1(3), DSE(11), UST(2), XYLT1(4), XYLT2(5) 17166208 35 33 35 16 15 8 3 5 4 0 0.890 1.000 1.000 570 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(2), GUSB(6), UCHL3(2), UGDH(1), UGT1A1(6), UGT1A10(3), UGT1A3(3), UGT1A4(2), UGT1A6(4), UGT1A7(3), UGT1A9(2), UGT2B15(5), UGT2B4(3) 25354389 42 33 42 21 2 11 8 16 5 0 0.979 1.000 1.000 571 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(12), CPT1A(6), LEP(1), LEPR(7), PRKAA1(3), PRKAA2(2), PRKAB1(1), PRKAB2(1), PRKAG1(2), PRKAG2(2) 21055991 37 32 37 16 4 8 6 8 11 0 0.963 1.000 1.000 572 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 8 CD44(3), ICAM1(2), ITGA4(6), ITGAL(4), ITGB1(5), ITGB2(7), SELE(2), SELL(6) 17677159 35 32 35 16 2 9 5 12 7 0 0.958 1.000 1.000 573 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(1), ACAD9(4), ADH1A(1), ADH4(1), ADH5(5), ADH6(2), ADH7(3), ADHFE1(2), DHRS2(4), DHRS3(1), DHRS7(1), ESCO1(4), ESCO2(1), PNPLA3(3), SH3GLB1(2) 35859756 35 31 35 12 3 11 9 9 2 1 0.804 1.000 1.000 574 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(4), COASY(4), DPYD(2), DPYS(3), ENPP1(7), ENPP3(5), PANK1(2), PANK2(1), PANK4(5), UPB1(2) 19335387 35 31 35 15 4 8 7 9 7 0 0.942 1.000 1.000 575 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(8), C5(5), C6(8), C7(8), C8A(2), C9(5) 18645496 36 30 36 10 4 15 6 6 5 0 0.633 1.000 1.000 576 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 CYP51A1(2), DHCR7(1), FDFT1(4), FDPS(5), HMGCR(4), HMGCS1(6), IDI1(5), LSS(2), NSDHL(3), PMVK(2), SQLE(2) 18751129 36 30 35 14 5 12 4 9 6 0 0.882 1.000 1.000 577 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT1(2), ACOT11(3), ACYP1(2), DHRS2(4), DHRS3(1), DHRS7(1), EHHADH(4), ESCO1(4), ESCO2(1), FN3K(3), GCDH(2), HADHA(2), PNPLA3(3), SH3GLB1(2), YOD1(1) 36932324 35 30 35 16 6 10 4 11 3 1 0.965 1.000 1.000 578 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(5), CAT(2), EPX(4), LPO(4), MPO(5), MTHFR(6), SHMT1(1), SHMT2(3), TPO(7) 16471638 37 30 37 11 10 11 3 7 6 0 0.487 1.000 1.000 579 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(4), CD28(2), CD3E(3), CD3G(3), CD8A(3), ICAM1(2), ITGAL(4), ITGB2(7), PTPRC(8) 15067559 36 30 36 12 2 12 8 8 6 0 0.636 1.000 1.000 580 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(4), CD28(2), CD3E(3), CD3G(3), CD4(4), ICAM1(2), ITGAL(4), ITGB2(7), PTPRC(8) 16070091 37 30 37 15 2 11 8 8 8 0 0.844 1.000 1.000 581 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM2(1), CCL2(1), CCR5(1), CXCR4(3), GNAQ(1), JUN(3), MAPK14(1), MAPK8(2), PLCG1(8), PRKCA(4), PTK2B(6), SYT1(1) 19447194 32 29 32 14 5 7 5 4 11 0 0.953 1.000 1.000 582 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 7 CD44(3), ICAM1(2), ITGAL(4), ITGAM(6), ITGB2(7), SELE(2), SELL(6) 15584377 30 29 30 13 2 8 5 6 9 0 0.899 1.000 1.000 583 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP5O(2), ATP6AP1(2), ATP6V0A1(5), ATP6V0A4(4), ATP6V0B(2), ATP6V0C(1), ATP6V1A(4), ATP6V1B1(4), ATP6V1B2(3), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), FDXR(1), SHMT1(1) 23193960 40 29 40 19 7 13 7 4 9 0 0.943 1.000 1.000 584 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(2), ATP6AP1(2), ATP6V0A1(5), ATP6V0A4(4), ATP6V0B(2), ATP6V0C(1), ATP6V1A(4), ATP6V1B1(4), ATP6V1B2(3), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), SHMT1(1) 22104455 39 28 39 19 7 13 7 3 9 0 0.953 1.000 1.000 585 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(10), EGF(5), EGFR(5), HGS(6), TF(5), TFRC(2) 18331243 33 28 32 11 6 9 6 6 6 0 0.830 1.000 1.000 586 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(2), ATP6AP1(2), ATP6V0A1(5), ATP6V0A4(4), ATP6V0B(2), ATP6V0C(1), ATP6V1A(4), ATP6V1B1(4), ATP6V1B2(3), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), SHMT1(1) 22104455 39 28 39 19 7 13 7 3 9 0 0.953 1.000 1.000 587 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNA1(1), IFNAR1(2), IFNAR2(1), JAK1(11), STAT1(4), STAT2(5), TYK2(7) 15421853 31 28 29 10 3 4 8 7 9 0 0.820 1.000 1.000 588 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 9 CD3E(3), CD3G(3), CD4(4), HLA-DRB1(10), LCK(2), PTPRC(8), ZAP70(3) 12017733 33 28 33 18 2 8 9 7 7 0 0.989 1.000 1.000 589 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(2), ATP6AP1(2), ATP6V0A1(5), ATP6V0A4(4), ATP6V0B(2), ATP6V0C(1), ATP6V1A(4), ATP6V1B1(4), ATP6V1B2(3), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), SHMT1(1) 22104455 39 28 39 19 7 13 7 3 9 0 0.953 1.000 1.000 590 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(5), AOC2(6), AOC3(3), CES1(4), DDHD1(4), ESCO1(4), ESCO2(1), LIPA(3), PLA1A(3), PNPLA3(3), PPME1(2), SH3GLB1(2) 35979390 40 27 40 11 5 9 11 9 5 1 0.581 1.000 1.000 591 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(6), LDLR(4), MBTPS1(3), MBTPS2(6), SCAP(1), SREBF1(3), SREBF2(5) 15977732 28 27 28 16 3 6 11 4 4 0 0.955 1.000 1.000 592 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM2(1), CAMK1(1), CAMK1G(5), CAMK2A(3), CAMK2B(2), CAMK2D(4), CAMK2G(2), CAMK4(5), CAMKK1(3), CAMKK2(3), CREB1(1), SYT1(1) 16476670 31 26 31 13 6 9 5 6 5 0 0.903 1.000 1.000 593 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(3), CD3E(3), CD3G(3), HLA-A(3), ICAM1(2), ITGAL(4), ITGB2(7), PRF1(2) 11914239 27 26 26 15 3 8 3 9 4 0 0.963 1.000 1.000 594 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(4), EIF2AK4(9), EIF2B5(4), EIF2S1(3), EIF2S2(3), EIF2S3(2), EIF5(2), GSK3B(2) 16407253 29 26 29 12 3 12 4 6 4 0 0.935 1.000 1.000 595 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(1), FDFT1(4), FDPS(5), HMGCR(4), IDI1(5), LSS(2), NQO1(1), NQO2(2), PMVK(2), SQLE(2) 15596846 28 25 27 13 4 9 4 7 4 0 0.947 1.000 1.000 596 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(16), GNA12(2), PRKACB(1), PRKACG(3), PRKAG1(2), PRKAR2A(2), PRKAR2B(2) 14388556 28 24 28 12 3 11 7 5 1 1 0.914 1.000 1.000 597 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 19 B3GNT1(1), B3GNT2(2), B3GNT3(1), B3GNT4(1), B3GNT5(4), B4GALT1(3), B4GALT3(2), B4GALT4(2), FUT1(1), FUT3(3), FUT5(2), FUT6(3), GCNT2(1), ST8SIA1(1) 20208777 27 24 27 12 5 8 4 7 3 0 0.879 1.000 1.000 598 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(4), ALDH1A2(1), ALDH1A3(6), ALDH1B1(1), ALDH2(1), ALDH3A1(3), ALDH3A2(3), ALDH9A1(1), EHHADH(4), HADHA(2) 17325132 26 24 25 12 3 4 8 4 7 0 0.930 1.000 1.000 599 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREB1(1), CREM(2), JUN(3), MAPK3(1), OPRK1(2), POLR2A(6), PRKACB(1), PRKACG(3), PRKAR1A(4), PRKAR2A(2), PRKAR2B(2) 18234872 27 23 27 18 4 7 6 5 5 0 0.998 1.000 1.000 600 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(4), POLR2A(6), POLR2B(5), POLR2C(1), POLR2D(1), POLR2F(3), POLR2G(1), POLR2H(1), POLR2J(1), POLRMT(5) 18100668 28 22 28 16 6 8 1 7 6 0 0.994 1.000 1.000 601 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(3), APAF1(11), CASP3(1), CASP9(2), DAXX(2), FAS(1), FASLG(2), IL1A(1), MAPKAPK2(1), MAPKAPK3(2) 15469859 26 21 26 10 3 11 5 3 3 1 0.846 1.000 1.000 602 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 16 ADAM10(3), ANKRD1(2), ATF3(2), CYR61(3), IFNG(2), IFRD1(2), IL18(2), IL1A(1), IL1R1(1), NR4A3(3), WDR1(1) 15407183 22 21 22 12 3 7 4 7 1 0 0.967 1.000 1.000 603 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 9 CCL11(1), CCR3(2), CD4(4), HLA-DRB1(10), IL4(1), IL5RA(4), IL6(1) 6929695 23 21 23 10 1 4 6 6 6 0 0.915 1.000 1.000 604 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(3), ACTR2(2), ACTR3(2), ARPC1A(3), ARPC1B(2), ARPC2(5), WASF1(6), WASL(4) 11863193 27 21 27 13 3 12 6 0 5 1 0.960 1.000 1.000 605 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(5), CYSLTR2(1), GPR161(6), GPR34(4), GPR39(3), GPR45(2), GPR65(1), GPR75(3) 14277703 25 20 25 11 2 4 2 13 4 0 0.894 1.000 1.000 606 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOSL2(1), IFNAR1(2), IFNAR2(1), MAPK8(2), NFKB1(5), RELA(3), TNFRSF11A(2), TRAF6(4) 15304799 20 20 20 10 5 4 3 4 4 0 0.950 1.000 1.000 607 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(5), PARK2(3), SNCA(1), SNCAIP(7), UBE2F(1), UBE2L3(1), UBE2L6(2) 9052388 20 19 20 10 3 8 4 4 1 0 0.955 1.000 1.000 608 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 12 CNR1(1), CNR2(1), DNMT1(8), PTAFR(1), PTGDR(2), PTGER2(3), PTGER4(1), PTGFR(1) 14369506 18 16 18 10 5 3 4 3 3 0 0.863 1.000 1.000 609 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CASP3(1), CD36(4), JUN(3), MAPK14(1), THBS1(8) 10280621 17 14 16 10 3 0 1 2 11 0 0.997 1.000 1.000 610 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT1(2), ACYP1(2), EHHADH(4), GCDH(2), HADHA(2), SDHB(2) 11272198 14 13 14 6 2 5 2 5 0 0 0.815 1.000 1.000 611 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(3), ADORA2A(3), ADORA3(1), P2RY1(4), P2RY2(1), P2RY6(1) 7788787 13 13 13 6 5 0 5 3 0 0 0.722 1.000 1.000 612 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(3), GPD2(3), NDUFA1(2), SDHB(2), UQCRC1(1) 9419011 11 10 11 6 2 1 2 6 0 0 0.921 1.000 1.000 613 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(1), ACADS(2), ACAT1(2), HADHA(2) 7615747 7 7 7 4 1 2 1 3 0 0 0.905 1.000 1.000 614 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 BGN(2), DCN(2), FMOD(1), KERA(3), LUM(2) 5259739 10 7 10 7 2 5 2 1 0 0 0.955 1.000 1.000 615 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 6 B3GNT1(1), FUT1(1), GCNT2(1), ST8SIA1(1) 7756482 4 4 4 6 0 1 0 3 0 0 0.998 1.000 1.000 616 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIAS(1), LIPT1(1) 2220249 2 2 2 2 0 1 0 1 0 0 0.973 1.000 1.000