Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.015 0.118 -9999.0 0.0 -0.312 3.0 3.0 epithelial cell differentiation 0.013 0.099 -9999.0 0.0 -0.218 4.0 4.0 CYFIP2 0.031 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.007 0.097 0.429 1.0 -9999.0 0.0 1.0 EGFR -0.005 0.118 -9999.0 0.0 -0.428 2.0 2.0 EPHA2 0.03 0.006 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 -0.013 0.083 0.18 1.0 -0.198 4.0 5.0 CTNNB1 0.03 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.05 0.06 -9999.0 0.0 -0.258 1.0 1.0 AQP5 -0.002 0.056 -9999.0 0.0 -9999.0 0.0 0.0 CTNND1 0.03 0.006 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.006 0.094 0.183 2.0 -0.208 4.0 6.0 regulation of calcium-dependent cell-cell adhesion -0.035 0.117 0.178 1.0 -0.241 6.0 7.0 EGF 0.022 0.008 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.015 0.085 -9999.0 0.0 -0.428 1.0 1.0 AQP3 -0.009 0.105 -9999.0 0.0 -0.439 1.0 1.0 cortical microtubule organization 0.013 0.099 -9999.0 0.0 -0.218 4.0 4.0 GO:0000145 -0.022 0.086 0.172 2.0 -0.199 4.0 6.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.018 0.102 -9999.0 0.0 -0.22 4.0 4.0 MLLT4 0.028 0.01 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.036 0.065 -9999.0 0.0 -0.193 4.0 4.0 ARF6 0.031 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.069 0.028 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.008 0.07 0.189 1.0 -9999.0 0.0 1.0 PVRL2 0.03 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.005 0.079 0.189 1.0 -0.211 3.0 4.0 ARF6/GTP 0.076 0.031 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.037 0.16 -9999.0 0.0 -0.428 4.0 4.0 EGFR/EGFR/EGF/EGF -0.003 0.112 -9999.0 0.0 -0.256 4.0 4.0 RhoA/GDP 0.013 0.096 -9999.0 0.0 -0.209 4.0 4.0 actin cytoskeleton organization -0.019 0.086 0.175 2.0 -0.193 4.0 6.0 IGF-1R heterotetramer 0.028 0.01 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.031 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.028 0.01 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.001 0.118 -9999.0 0.0 -0.428 2.0 2.0 DIAPH1 0.029 0.124 -9999.0 0.0 -9999.0 0.0 0.0 Wnt receptor signaling pathway -0.013 0.099 0.218 4.0 -9999.0 0.0 4.0 RHOA 0.029 0.008 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.035 0.065 -9999.0 0.0 -0.194 4.0 4.0 CTNNA1 0.03 0.006 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.019 0.087 0.176 2.0 -0.197 4.0 6.0 EFNA1 0.029 0.008 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.021 0.073 0.186 1.0 -0.203 3.0 4.0 Ephrin A1/EPHA2 0.011 0.092 -9999.0 0.0 -0.206 4.0 4.0 SEC6/SEC8 -0.003 0.052 -9999.0 0.0 -0.183 2.0 2.0 MGAT3 -0.036 0.119 0.18 1.0 -0.244 6.0 7.0 HGF/MET 0.009 0.095 -9999.0 0.0 -0.215 4.0 4.0 HGF 0.012 0.085 -9999.0 0.0 -0.428 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.015 0.119 -9999.0 0.0 -0.314 3.0 3.0 actin cable formation 0.019 0.11 0.518 1.0 -9999.0 0.0 1.0 KIAA1543 -0.034 0.099 0.173 2.0 -0.202 6.0 8.0 KIFC3 -0.02 0.094 0.18 1.0 -0.211 5.0 6.0 NCK1 0.029 0.008 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.03 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.006 0.095 0.184 2.0 -0.211 4.0 6.0 NCK1/GIT1 0.043 0.012 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.013 0.099 -9999.0 0.0 -0.218 4.0 4.0 EXOC4 0.028 0.01 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.006 0.095 0.184 2.0 -0.211 4.0 6.0 PIP5K1C -0.007 0.095 0.184 2.0 -0.211 4.0 6.0 LIMA1 0.013 0.085 -9999.0 0.0 -0.428 1.0 1.0 ABI1 0.03 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.007 0.119 0.359 2.0 -9999.0 0.0 2.0 adherens junction assembly -0.063 0.168 -9999.0 0.0 -0.569 2.0 2.0 IGF-1R heterotetramer/IGF1 -0.005 0.119 -9999.0 0.0 -0.244 5.0 5.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.04 0.016 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.004 0.118 -9999.0 0.0 -0.428 2.0 2.0 PLEKHA7 -0.022 0.109 0.184 2.0 -0.211 6.0 8.0 mol:GTP 0.067 0.027 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity 0.001 0.089 0.319 1.0 -9999.0 0.0 1.0 cortical actin cytoskeleton stabilization -0.015 0.118 -9999.0 0.0 -0.312 3.0 3.0 regulation of cell-cell adhesion -0.019 0.086 0.175 2.0 -0.193 4.0 6.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.015 0.119 -9999.0 0.0 -0.314 3.0 3.0