rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(2) 51556 2 2 2 0 1 0 0 1 0 0 0.590 0.0885 1.000 2 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 GNGT1(1), HTR2C(1), PLCB1(8), TUB(2) 517190 12 9 10 7 2 1 0 3 6 0 0.904 0.216 1.000 3 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3D(1), CD3G(2) 84242 3 3 3 3 0 1 0 1 1 0 0.943 0.586 1.000 4 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(1), GLS2(2) 330026 3 3 2 1 0 0 2 1 0 0 0.645 0.659 1.000 5 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDOB(1), ALDOC(1) 284076 2 2 2 0 1 1 0 0 0 0 0.470 0.754 1.000 6 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(1) 120022 1 1 1 1 1 0 0 0 0 0 0.881 0.758 1.000 7 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 4 AOC2(2), AOC3(4), ESD(2) 360646 8 6 6 0 3 5 0 0 0 0 0.0373 0.760 1.000 8 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPL(2), ALPP(13), ALPPL2(5), FPGS(2), GCH1(1), GGH(3) 518717 26 12 18 8 6 9 3 7 1 0 0.204 0.768 1.000 9 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AASDHPPT(2), AASS(2) 342070 4 4 4 2 0 2 0 1 1 0 0.861 0.787 1.000 10 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(1), IL12B(2) 222942 3 3 2 9 2 0 0 0 1 0 1.000 0.858 1.000 11 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 9 BPNT1(1), PAPSS1(5), PAPSS2(1), SULT1A2(3), SUOX(1) 613543 11 7 9 2 4 2 0 4 1 0 0.359 0.872 1.000 12 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 SPCS1(1) 225000 1 1 1 3 0 0 0 0 1 0 1.000 0.885 1.000 13 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(4), ITPKA(1), ITPKB(10) 444148 15 10 10 9 3 7 0 3 2 0 0.854 0.890 1.000 14 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(2), GLS(1), PRODH(4) 430702 7 5 6 3 3 1 1 2 0 0 0.649 0.947 1.000 15 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 GRIA2(3) 278637 3 3 3 5 0 0 0 2 1 0 0.999 0.960 1.000 16 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CD3D(1), CD3G(2) 235227 3 3 3 7 0 1 0 1 1 0 0.998 0.961 1.000 17 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDFT1(2), SQLE(1) 243414 3 3 3 9 0 0 2 0 1 0 1.000 0.968 1.000 18 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AASDH(8), AASDHPPT(2), AASS(2) 502133 12 8 9 7 2 4 0 4 2 0 0.904 0.969 1.000 19 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 6 FUT1(1), FUT2(1), FUT3(6), FUT5(6) 318938 14 7 9 9 5 2 0 6 1 0 0.924 0.975 1.000 20 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRNA1(1), SNAP25(1) 230341 2 2 2 7 0 0 0 1 1 0 0.999 0.975 1.000 21 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(1), CHAT(4), CHKA(1), PDHA2(2), PEMT(4) 503543 12 10 10 5 5 5 1 1 0 0 0.476 0.976 1.000 22 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(4), PNPO(1) 351159 5 5 5 9 1 3 0 0 1 0 0.999 0.981 1.000 23 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 8 CHUK(1), EIF2S2(1), NFKB1(3), NFKBIA(3) 688437 8 8 7 6 2 2 0 1 3 0 0.963 0.986 1.000 24 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 GBA(2), GGT1(6), SHMT1(3), SHMT2(1) 423071 12 12 8 5 3 3 1 4 1 0 0.676 0.987 1.000 25 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYA(1), NFYC(2), RB1(1), SP1(1), SP3(2) 488712 7 6 7 5 1 4 0 0 2 0 0.873 0.987 1.000 26 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 12 CCNA1(1), CCND1(1), CDKN1B(1), CDKN2A(1), E2F1(2), E2F2(3) 612430 9 7 8 9 2 1 1 3 2 0 0.986 0.987 1.000 27 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CUL1(2), E2F1(2), RB1(1) 618831 5 5 5 6 2 1 0 0 2 0 0.987 0.988 1.000 28 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CDKN1B(1), CUL1(2), E2F1(2), NEDD8(1), RB1(1), SKP2(1) 626122 8 7 8 6 3 1 0 1 3 0 0.934 0.989 1.000 29 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 8 EIF2AK4(1), EIF2B5(4), EIF2S2(1), EIF2S3(2), PPP1CA(1) 687368 9 9 8 4 2 3 0 4 0 0 0.790 0.989 1.000 30 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(1), CUL1(2), E2F1(2), RB1(1), SKP2(1) 635036 7 6 7 7 3 1 0 0 3 0 0.972 0.990 1.000 31 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 7 ACLY(2), PC(1) 603220 3 3 2 1 0 0 0 3 0 0 0.794 0.991 1.000 32 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CCL2(1), CSF1(2), MST1R(6), TNF(3) 468866 12 8 10 7 1 5 3 2 1 0 0.838 0.994 1.000 33 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 8 ECHS1(1), HADHB(1), HSD17B4(4), PPT1(1) 524179 7 5 6 6 0 5 1 0 1 0 0.941 0.996 1.000 34 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 MTMR1(3), MTMR2(4), PHPT1(1), THTPA(2) 464267 10 8 9 8 2 2 0 5 1 0 0.975 0.996 1.000 35 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(3), ACADM(1), ACADS(1), ACAT1(2), ECHS1(1) 400262 8 8 6 5 0 3 0 4 1 0 0.927 0.997 1.000 36 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 CPS1(5), GLS(1) 565382 6 5 3 6 0 0 0 5 1 0 0.994 0.998 1.000 37 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 10 CDK5R1(1), CSNK1A1(2), PPP2CA(1) 608846 4 4 4 6 0 1 0 1 2 0 0.994 0.999 1.000 38 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 CLOCK(2), CSNK1E(1), PER1(4) 633431 7 5 6 9 1 2 0 3 1 0 0.999 1.000 1.000 39 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT1(2), ACAT2(1), BDH1(1), BDH2(2), HMGCS2(1), OXCT1(2), OXCT2(2) 555702 11 8 9 9 3 3 1 3 1 0 0.970 1.000 1.000 40 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(1), MAPK8(1), NFKB1(3), TNFRSF13B(4), TNFSF13(3), TNFSF13B(1), TRAF3(4), TRAF6(1) 1058732 18 9 14 9 3 11 1 1 2 0 0.815 1.000 1.000 41 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 187 ACTB(5), ACTN1(3), ACTN2(1), ACTN4(1), AKT2(1), ARHGAP5(2), BCAR1(2), BCL2(1), BIRC2(1), BRAF(3), CAPN2(4), CAV1(1), CAV2(2), CCND1(1), CCND2(2), CCND3(3), CHAD(1), COL11A1(7), COL11A2(5), COL1A2(1), COL2A1(3), COL3A1(7), COL4A1(3), COL4A2(5), COL4A4(11), COL5A1(5), COL5A2(5), COL5A3(12), COL6A1(5), COL6A2(6), COL6A6(4), COMP(2), DOCK1(7), EGF(4), EGFR(4), ELK1(1), ERBB2(3), FARP2(10), FLNA(4), FLNC(7), FLT1(2), FN1(2), GRB2(1), IBSP(5), ILK(1), ITGA1(3), ITGA10(5), ITGA11(7), ITGA2(1), ITGA2B(2), ITGA3(1), ITGA4(5), ITGA5(2), ITGA6(4), ITGA7(1), ITGA8(1), ITGA9(2), ITGB3(3), ITGB4(2), KDR(8), LAMA1(26), LAMA2(8), LAMA3(6), LAMA4(5), LAMB1(2), LAMB2(5), LAMB3(4), LAMB4(5), LAMC1(4), LAMC2(3), LAMC3(6), MAP2K1(2), MAPK8(1), MET(2), MYLK(8), PAK2(11), PAK4(2), PAK6(3), PAK7(7), PARVA(1), PARVG(1), PDGFC(1), PDGFRB(2), PDPK1(1), PIK3CA(2), PIK3CD(1), PIK3CG(3), PIK3R2(1), PIK3R3(1), PIP5K1C(2), PPP1CA(1), PPP1R12A(1), PRKCG(2), PTEN(2), PTK2(2), RAC1(1), RAC3(1), RAF1(4), RAPGEF1(1), RELN(9), RHOA(2), ROCK2(2), SHC2(1), SHC3(1), SOS1(1), SOS2(1), SPP1(1), THBS1(5), THBS2(1), THBS3(2), THBS4(3), TLN1(6), TLN2(6), TNC(10), TNN(10), TNR(4), TNXB(14), VAV1(3), VAV2(3), VAV3(4), VEGFB(1), VEGFC(2), VTN(2), VWF(11) 26316426 459 41 369 655 124 145 26 124 37 3 1.000 1.000 1.000 42 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 228 ADCYAP1R1(4), ADORA1(1), ADORA3(4), ADRA1A(3), ADRA2B(2), ADRA2C(1), ADRB1(1), ADRB2(3), AGTR1(2), AGTR2(3), AVPR1B(3), CALCR(5), CALCRL(2), CCKBR(1), CHRM3(5), CNR2(4), CRHR1(1), CTSG(1), CYSLTR1(1), CYSLTR2(2), DRD2(1), DRD3(1), DRD5(5), EDNRA(1), F2(1), F2R(1), F2RL2(1), F2RL3(1), FPR1(8), FSHR(5), GABBR1(1), GABBR2(3), GABRA1(2), GABRA2(2), GABRA3(1), GABRA5(1), GABRA6(3), GABRB1(1), GABRD(2), GABRE(1), GABRG3(6), GABRP(2), GABRQ(4), GABRR2(2), GALR1(3), GALR2(1), GALR3(1), GH1(2), GH2(1), GHR(2), GHRHR(2), GHSR(1), GIPR(1), GLP1R(3), GLP2R(3), GLRB(1), GPR156(1), GPR35(1), GPR50(7), GPR63(1), GRIA2(3), GRID1(7), GRID2(5), GRIK1(3), GRIK2(1), GRIK3(1), GRIK4(3), GRIK5(1), GRIN2A(2), GRIN2B(2), GRIN2C(3), GRIN2D(1), GRIN3A(13), GRIN3B(10), GRM1(2), GRM2(1), GRM4(1), GRM5(1), GRM6(5), GRM7(1), HCRTR1(2), HCRTR2(2), HRH1(1), HRH2(1), HRH4(3), HTR1B(2), HTR1F(3), HTR2A(2), HTR2C(1), HTR4(1), HTR5A(1), HTR7(1), LEPR(10), LHB(3), MAS1(1), MC1R(4), MC3R(2), MC5R(1), MCHR1(2), MTNR1A(2), MTNR1B(2), NMUR1(2), NMUR2(2), NPBWR2(2), NPFFR2(2), NPY2R(1), NTSR2(1), OPRK1(1), OPRM1(2), OXTR(1), P2RX3(5), P2RX4(2), P2RX7(15), P2RY1(1), P2RY10(1), P2RY11(3), P2RY13(1), P2RY4(1), P2RY6(1), PARD3(2), PRLHR(1), PRLR(2), PRSS1(4), PTAFR(2), PTGFR(1), PTGIR(2), PTH2R(2), RXFP2(4), SCTR(1), SSTR1(1), SSTR2(1), SSTR3(1), SSTR4(6), SSTR5(3), TAAR2(1), TAAR6(2), TAAR8(1), TACR2(4), TACR3(1), THRA(1), THRB(2), TRPV1(5), TSHR(3), VIPR2(1) 15716193 347 40 283 448 80 121 26 102 18 0 1.000 1.000 1.000 43 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 143 APC(4), AXIN2(4), BTRC(1), CAMK2G(1), CCND1(1), CCND2(2), CCND3(3), CER1(4), CHD8(4), CREBBP(7), CSNK1A1(2), CSNK1A1L(5), CSNK1E(1), CSNK2A1(4), CSNK2B(1), CUL1(2), DAAM2(4), DKK2(2), DVL1(1), EP300(5), FZD1(1), FZD10(1), FZD2(1), FZD3(1), FZD5(2), FZD6(3), FZD7(1), LRP5(2), LRP6(1), MAPK8(1), MMP7(2), MYC(7), NFAT5(1), NFATC1(6), NFATC2(2), NFATC3(1), NFATC4(1), NKD2(2), PLCB1(8), PLCB3(2), PLCB4(2), PPP2CA(1), PPP2R1B(1), PPP2R2B(3), PPP2R2C(1), PPP3CA(1), PPP3CC(1), PRICKLE2(2), PRKACA(1), PRKACG(2), PRKCG(2), PRKX(1), PSEN1(1), RAC1(1), RAC3(1), RHOA(2), ROCK2(2), SENP2(1), SFRP4(2), SKP1(1), SMAD3(1), SOX17(1), TBL1XR1(2), TCF7(2), TCF7L1(2), VANGL1(4), VANGL2(1), WNT10A(1), WNT16(4), WNT3A(1), WNT5A(1), WNT7B(1), WNT8B(2), WNT9B(2) 11891521 158 40 141 197 42 43 5 44 24 0 1.000 1.000 1.000 44 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 242 ACVR1C(2), AKT2(1), ATF4(4), BDNF(3), BRAF(3), CACNA1A(3), CACNA1B(7), CACNA1C(8), CACNA1E(5), CACNA1F(6), CACNA1G(2), CACNA1H(15), CACNA1I(1), CACNA1S(8), CACNA2D1(3), CACNA2D2(2), CACNA2D3(1), CACNA2D4(3), CACNB2(2), CACNB4(1), CACNG1(1), CACNG3(1), CACNG6(2), CACNG7(1), CHUK(1), DUSP16(2), DUSP4(2), DUSP8(1), ECSIT(3), EGF(4), EGFR(4), ELK1(1), FGF12(1), FGF14(1), FGF16(1), FGF21(2), FGF5(1), FGF6(3), FGFR2(2), FGFR4(6), FLNA(4), FLNC(7), GRB2(1), IKBKB(2), IL1A(2), IL1R1(1), IL1R2(1), MAP2K1(2), MAP2K3(4), MAP2K4(1), MAP3K1(7), MAP3K10(1), MAP3K13(1), MAP3K4(1), MAP3K5(1), MAP3K6(5), MAP4K1(1), MAP4K3(2), MAP4K4(1), MAPK11(1), MAPK7(1), MAPK8(1), MAPK8IP1(2), MAPK8IP3(2), MAPKAPK2(1), MAPKAPK5(2), MEF2C(1), MKNK1(1), MKNK2(3), MOS(2), MYC(7), NF1(2), NFATC2(2), NFATC4(1), NFKB1(3), NFKB2(3), NTRK1(3), PAK2(11), PDGFRB(2), PLA2G2D(1), PLA2G3(4), PLA2G4A(1), PLA2G5(1), PPM1A(1), PPP3CA(1), PPP3CC(1), PRKACA(1), PRKACG(2), PRKCG(2), PRKX(1), PTPN5(3), PTPN7(1), PTPRR(3), RAC1(1), RAC3(1), RAF1(4), RAPGEF2(1), RASA1(2), RASA2(2), RASGRF1(2), RASGRF2(1), RASGRP4(1), RPS6KA1(2), RPS6KA2(1), RPS6KA5(1), RPS6KA6(1), RRAS2(1), SOS1(1), SOS2(1), STK3(2), STK4(1), TAOK1(1), TAOK2(2), TGFB2(1), TNF(3), TRAF6(1), ZAK(3) 21423931 276 39 236 402 85 86 13 65 27 0 1.000 1.000 1.000 45 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 148 AKT2(1), CBL(1), CBLB(1), CBLC(5), CCND1(1), CCND2(2), CCND3(3), CISH(1), CLCF1(1), CREBBP(7), CRLF2(1), CSF2(1), CSF2RA(2), CSF2RB(3), CSF3R(2), EP300(5), EPOR(1), GH1(2), GH2(1), GHR(2), GRB2(1), IFNA1(2), IFNA10(4), IFNA13(1), IFNA14(2), IFNA16(4), IFNA17(1), IFNA5(1), IFNAR1(4), IFNAR2(3), IFNGR2(2), IL10RA(4), IL10RB(2), IL11(1), IL12B(2), IL12RB1(8), IL12RB2(2), IL13RA1(1), IL15RA(1), IL19(1), IL21R(1), IL22RA1(2), IL22RA2(2), IL23R(2), IL24(3), IL2RA(1), IL2RB(2), IL3(3), IL3RA(4), IL4R(15), IL5RA(2), IL6(2), IL6R(2), IL6ST(4), IL7R(7), IL9(1), IL9R(2), JAK1(2), JAK2(2), JAK3(2), LEPR(10), LIFR(3), MYC(7), OSMR(2), PIAS1(1), PIK3CA(2), PIK3CD(1), PIK3CG(3), PIK3R2(1), PIK3R3(1), PIM1(38), PRLR(2), PTPN6(4), SOCS1(9), SOCS3(1), SOCS7(2), SOS1(1), SOS2(1), SPRED1(1), SPRED2(1), SPRY3(1), STAT1(1), STAT2(3), STAT6(4), TPO(10), TYK2(3) 10466120 264 39 217 216 32 97 22 89 21 3 1.000 1.000 1.000 46 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 125 ACTB(5), CHAD(1), COL11A1(7), COL11A2(5), COL17A1(3), COL1A2(1), COL2A1(3), COL3A1(7), COL4A1(3), COL4A2(5), COL4A4(11), COL5A1(5), COL5A2(5), COL5A3(12), COL6A1(5), COL6A2(6), COL6A6(4), COMP(2), DES(2), DSC1(3), DSC2(1), DSC3(8), DSG2(2), DSG3(6), DSG4(2), FN1(2), GJA1(1), GJA4(5), GJA9(5), GJB3(1), GJB4(3), GJB7(3), GJD2(1), GJD4(1), IBSP(5), ITGA6(4), ITGB4(2), KRT1(4), KRT10(2), KRT12(2), KRT14(4), KRT15(3), KRT16(2), KRT17(1), KRT19(2), KRT20(2), KRT23(4), KRT24(2), KRT25(3), KRT27(6), KRT31(3), KRT32(16), KRT33A(5), KRT33B(5), KRT34(2), KRT35(4), KRT36(3), KRT37(16), KRT38(2), KRT39(4), KRT40(23), KRT5(7), KRT6A(4), KRT6B(5), KRT6C(7), KRT7(3), KRT72(10), KRT73(4), KRT75(5), KRT76(6), KRT77(7), KRT78(4), KRT79(3), KRT81(3), KRT83(4), KRT85(1), KRT86(3), KRT9(1), LAMA1(26), LAMA2(8), LAMA3(6), LAMA4(5), LAMB1(2), LAMB2(5), LAMB3(4), LAMB4(5), LAMC1(4), LAMC2(3), LAMC3(6), LMNA(3), NES(7), PRPH(2), RELN(9), SPP1(1), THBS1(5), THBS2(1), THBS3(2), THBS4(3), TNC(10), TNN(10), TNR(4), TNXB(14), VTN(2), VWF(11) 16806935 502 38 376 533 163 154 28 117 38 2 1.000 1.000 1.000 47 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 124 ABL1(3), ABLIM1(2), ABLIM2(1), ABLIM3(4), ARHGEF12(2), DCC(4), EFNA1(1), EFNB1(1), EPHA1(3), EPHA2(2), EPHA3(7), EPHA5(3), EPHA6(3), EPHA7(2), EPHA8(1), EPHB1(3), EPHB2(1), EPHB4(2), EPHB6(2), GNAI2(2), L1CAM(1), LIMK1(1), LIMK2(1), LRRC4C(1), MET(2), NCK1(2), NFAT5(1), NFATC1(6), NFATC2(2), NFATC3(1), NFATC4(1), NGEF(1), NRP1(5), NTN4(4), PAK2(11), PAK4(2), PAK6(3), PAK7(7), PLXNA1(1), PLXNA2(10), PLXNA3(4), PLXNB1(1), PLXNB2(5), PLXNB3(10), PLXNC1(1), PPP3CA(1), PPP3CC(1), PTK2(2), RAC1(1), RAC3(1), RASA1(2), RGS3(4), RHOA(2), ROBO1(2), ROBO2(3), ROBO3(2), ROCK2(2), SEMA3A(1), SEMA3C(3), SEMA3D(4), SEMA3E(4), SEMA3F(1), SEMA3G(1), SEMA4B(2), SEMA4D(5), SEMA4F(1), SEMA4G(1), SEMA5A(2), SEMA5B(6), SEMA6A(2), SEMA6B(2), SEMA6C(2), SEMA6D(7), SEMA7A(1), SLIT1(2), SLIT2(3), SLIT3(4), SRGAP1(2), SRGAP2(2), SRGAP3(1), UNC5B(7), UNC5C(6), UNC5D(1) 14650195 229 38 190 367 73 70 11 65 10 0 1.000 1.000 1.000 48 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 81 ACVR1(1), ACVRL1(1), AURKB(3), BMPR1A(3), BUB1(1), CDKL1(2), CDKL2(1), CDS1(1), CDS2(1), CLK2(2), CSNK2A1(4), CSNK2B(1), DGKA(1), DGKB(2), DGKD(1), DGKE(1), DGKG(2), DGKH(2), DGKQ(1), DGKZ(4), INPP4A(3), INPP4B(5), INPP5A(2), INPPL1(1), ITPKA(1), ITPKB(10), MAP3K10(1), MOS(2), NEK1(8), NEK3(3), OCRL(1), PAK4(2), PIK3C2A(3), PIK3C2B(1), PIK3C2G(10), PIK3CA(2), PIK3CG(3), PIM2(1), PLCB1(8), PLCB3(2), PLCB4(2), PLCD1(2), PLCG1(3), PLCG2(5), PRKACA(1), PRKACG(2), PRKCD(1), PRKCG(2), PRKCQ(2), PRKD1(3), PRKG1(3), RAF1(4), RPS6KA1(2), RPS6KA2(1), STK11(1) 8511200 138 37 120 214 34 38 7 42 17 0 1.000 1.000 1.000 49 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 167 ADCY2(7), ADCY3(2), ADCY4(2), ADCY8(1), ADCY9(4), ADRA1A(3), ADRA1D(2), ADRB1(1), ADRB2(3), AGTR1(2), ATP2A3(2), ATP2B4(1), AVPR1B(3), BST1(4), CACNA1A(3), CACNA1B(7), CACNA1C(8), CACNA1E(5), CACNA1F(6), CACNA1G(2), CACNA1H(15), CACNA1I(1), CACNA1S(8), CAMK2G(1), CAMK4(1), CCKBR(1), CHRM3(5), CHRNA7(1), CYSLTR1(1), CYSLTR2(2), EDNRA(1), EGFR(4), ERBB2(3), ERBB3(1), ERBB4(4), F2R(1), GNA14(1), GNAS(1), GRIN2A(2), GRIN2C(3), GRIN2D(1), GRM1(2), GRM5(1), HRH1(1), HRH2(1), HTR2A(2), HTR2C(1), HTR4(1), HTR5A(1), HTR7(1), ITPKA(1), ITPKB(10), ITPR1(4), ITPR2(3), ITPR3(2), MYLK(8), NOS1(3), OXTR(1), P2RX3(5), P2RX4(2), P2RX7(15), PDE1B(1), PDE1C(5), PDGFRB(2), PHKA1(1), PHKB(2), PLCB1(8), PLCB3(2), PLCB4(2), PLCD1(2), PLCD4(2), PLCE1(8), PLCG1(3), PLCG2(5), PPID(2), PPP3CA(1), PPP3CC(1), PRKACA(1), PRKACG(2), PRKCG(2), PRKX(1), PTAFR(2), PTGFR(1), PTK2B(4), RYR1(4), RYR2(9), RYR3(6), SLC25A5(2), SLC25A6(2), SLC8A1(1), SLC8A3(1), SPHK1(1), SPHK2(1), TACR2(4), TACR3(1), TRPC1(1), VDAC3(2) 20484450 286 36 234 521 86 79 17 71 32 1 1.000 1.000 1.000 50 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 241 ACVR1(1), BMP2(2), BMP7(1), BMPR1A(3), CCL11(1), CCL14(5), CCL15(1), CCL18(1), CCL2(1), CCL23(2), CCL25(2), CCL8(3), CCR1(1), CCR2(3), CCR3(1), CCR6(1), CCR8(5), CD27(3), CLCF1(1), CRLF2(1), CSF1(2), CSF2(1), CSF2RA(2), CSF2RB(3), CSF3R(2), CX3CL1(2), CXCL14(1), CXCL2(1), CXCL3(1), CXCR6(1), EDA(1), EDA2R(4), EGF(4), EGFR(4), EPOR(1), FLT1(2), FLT3(1), FLT3LG(1), FLT4(5), GDF5(3), GH1(2), GH2(1), GHR(2), IFNA1(2), IFNA10(4), IFNA13(1), IFNA14(2), IFNA16(4), IFNA17(1), IFNA5(1), IFNAR1(4), IFNAR2(3), IFNGR2(2), IL10RA(4), IL10RB(2), IL11(1), IL12B(2), IL12RB1(8), IL12RB2(2), IL13RA1(1), IL15RA(1), IL17B(1), IL17RA(2), IL17RB(1), IL18R1(1), IL19(1), IL1A(2), IL1R1(1), IL1R2(1), IL21R(1), IL22RA1(2), IL22RA2(2), IL23R(2), IL24(3), IL25(1), IL2RA(1), IL2RB(2), IL3(3), IL3RA(4), IL4R(15), IL5RA(2), IL6(2), IL6R(2), IL6ST(4), IL7R(7), IL9(1), IL9R(2), INHBB(1), INHBC(1), INHBE(1), KDR(8), KITLG(1), LEPR(10), LIFR(3), LTB(5), MET(2), NGFR(2), OSMR(2), PDGFC(1), PDGFRB(2), PLEKHO2(5), PRLR(2), TGFB2(1), TNF(3), TNFRSF10A(7), TNFRSF10B(4), TNFRSF10C(7), TNFRSF10D(1), TNFRSF11A(3), TNFRSF11B(2), TNFRSF13B(4), TNFRSF18(3), TNFRSF19(4), TNFRSF1B(3), TNFRSF21(1), TNFRSF6B(1), TNFSF13(3), TNFSF13B(1), TNFSF15(1), TNFSF4(1), TNFSF9(1), TPO(10), VEGFB(1), VEGFC(2), XCL1(2) 12657210 309 36 239 281 48 119 26 99 17 0 1.000 1.000 1.000 51 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 120 ALCAM(3), CADM1(1), CADM3(1), CD2(1), CD22(2), CD274(1), CD276(7), CD58(1), CD6(8), CD80(2), CD86(1), CD8B(5), CD99(3), CDH1(1), CDH15(2), CDH2(4), CDH3(6), CDH4(2), CLDN18(1), CLDN22(2), CLDN5(2), CNTN1(2), CNTN2(5), CNTNAP1(2), CTLA4(1), HLA-A(93), HLA-B(42), HLA-C(60), HLA-DMA(4), HLA-DMB(1), HLA-DOB(1), HLA-DPA1(29), HLA-DQA1(19), HLA-DQA2(8), HLA-DQB1(30), HLA-DRA(2), HLA-DRB1(46), HLA-E(1), HLA-G(5), ICAM1(6), ICOSLG(4), ITGA4(5), ITGA6(4), ITGA8(1), ITGA9(2), ITGAL(1), ITGAM(6), L1CAM(1), MPZL1(1), NCAM1(1), NCAM2(5), NEGR1(3), NFASC(5), NLGN1(1), NRCAM(2), NRXN1(2), NRXN2(2), NRXN3(3), PDCD1LG2(2), PTPRC(1), PTPRF(1), PTPRM(1), PVR(3), PVRL1(3), PVRL2(1), SDC3(5), SDC4(5), SELE(3), SELL(3), SELP(6), SIGLEC1(4), VCAM1(1), VCAN(21) 10413394 522 36 369 436 90 191 23 181 32 5 1.000 1.000 1.000 52 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 125 ACTB(5), ACTN1(3), ACTN2(1), ACTN4(1), AKT2(1), AMOTL1(5), ASH1L(2), CGN(5), CLDN18(1), CLDN22(2), CLDN5(2), CSNK2A1(4), CSNK2B(1), CTNNA2(3), CTNNA3(6), CTTN(1), EPB41(2), EPB41L1(1), EPB41L2(1), EPB41L3(6), EXOC4(3), GNAI2(2), HCLS1(7), IGSF5(4), INADL(11), LLGL1(2), LLGL2(9), MAGI1(3), MAGI2(4), MLLT4(1), MPDZ(6), MYH1(4), MYH10(3), MYH11(5), MYH13(5), MYH14(4), MYH15(6), MYH2(2), MYH3(1), MYH4(14), MYH6(6), MYH7(1), MYH7B(4), MYH8(5), MYH9(6), PARD3(2), PARD6G(1), PPP2CA(1), PPP2R1B(1), PPP2R2B(3), PPP2R2C(1), PPP2R3A(13), PPP2R3B(3), PPP2R4(1), PRKCD(1), PRKCG(2), PRKCQ(2), PTEN(2), RHOA(2), RRAS2(1), SPTAN1(1), SYMPK(2), TJP1(3), TJP2(5), TJP3(5), YES1(1), ZAK(3) 14066887 227 36 182 325 69 72 19 47 20 0 1.000 1.000 1.000 53 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 72 CDS1(1), CDS2(1), DGKA(1), DGKB(2), DGKD(1), DGKE(1), DGKG(2), DGKH(2), DGKI(5), DGKQ(1), DGKZ(4), IMPA2(1), INPP4A(3), INPP4B(5), INPP5A(2), INPP5B(4), INPPL1(1), ITPKA(1), ITPKB(10), ITPR1(4), ITPR2(3), ITPR3(2), OCRL(1), PI4KA(4), PIK3C2A(3), PIK3C2B(1), PIK3C2G(10), PIK3C3(1), PIK3CA(2), PIK3CD(1), PIK3CG(3), PIK3R2(1), PIK3R3(1), PIP5K1A(1), PIP5K1B(1), PIP5K1C(2), PLCB1(8), PLCB3(2), PLCB4(2), PLCD1(2), PLCD4(2), PLCE1(8), PLCG1(3), PLCG2(5), PRKCG(2), PTEN(2), SYNJ1(2), SYNJ2(3) 9334304 130 35 115 251 29 35 8 37 21 0 1.000 1.000 1.000 54 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 199 ACTN1(3), ACTN2(1), ACTN4(1), APC(4), ARHGEF1(1), ARHGEF12(2), ARHGEF4(2), ARPC1B(3), BCAR1(2), BRAF(3), CHRM3(5), CSK(3), DIAPH3(2), DOCK1(7), EGF(4), EGFR(4), EZR(1), F2(1), F2R(1), FGF12(1), FGF14(1), FGF16(1), FGF21(2), FGF5(1), FGF6(3), FGFR2(2), FGFR4(6), FN1(2), GNA13(2), GSN(4), IQGAP2(4), IQGAP3(8), ITGA1(3), ITGA10(5), ITGA11(7), ITGA2(1), ITGA2B(2), ITGA3(1), ITGA4(5), ITGA5(2), ITGA6(4), ITGA7(1), ITGA8(1), ITGA9(2), ITGAD(2), ITGAE(8), ITGAL(1), ITGAM(6), ITGAX(6), ITGB3(3), ITGB4(2), LIMK1(1), LIMK2(1), MAP2K1(2), MOS(2), MSN(2), MYH10(3), MYH14(4), MYH9(6), MYLK(8), NCKAP1(2), NCKAP1L(1), PAK2(11), PAK4(2), PAK6(3), PAK7(7), PDGFRB(2), PFN1(3), PIK3CA(2), PIK3CD(1), PIK3CG(3), PIK3R2(1), PIK3R3(1), PIP5K1A(1), PIP5K1B(1), PIP5K1C(2), PPP1CA(1), PPP1R12A(1), PPP1R12B(1), PTK2(2), RAC1(1), RAC3(1), RAF1(4), RHOA(2), ROCK2(2), RRAS2(1), SCIN(5), SOS1(1), SOS2(1), SSH1(2), SSH2(3), SSH3(1), TIAM1(8), TIAM2(9), VAV1(3), VAV2(3), VAV3(4), WAS(1), WASF1(1), WASL(1) 20650689 280 34 225 414 86 87 13 76 17 1 1.000 1.000 1.000 55 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 90 ACTB(5), BCL2(1), CABIN1(4), CAMK4(1), CD3G(2), CDKN1A(4), CREBBP(7), CSF2(1), CSNK2A1(4), CSNK2B(1), CTLA4(1), EGR2(1), EP300(5), GATA3(2), GATA4(2), IFNA1(2), IL2RA(1), IL3(3), IL6(2), JUNB(1), MAPK8(1), MEF2B(3), NFAT5(1), NFATC1(6), NFATC2(2), NFATC3(1), NFATC4(1), NFKB2(3), NFKBIB(1), NUP214(3), P2RX7(15), PPP3CC(1), PTPRC(1), SFN(2), SLA(1), SP1(1), SP3(2), TNF(3), VAV1(3), VAV2(3), VAV3(4), XPO5(2) 6659209 110 33 93 132 25 36 4 31 14 0 1.000 1.000 1.000 56 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 83 ABL1(3), AKT2(1), BRAF(3), CAMK2G(1), CBL(1), CBLB(1), CBLC(5), CDKN1A(4), CDKN1B(1), EGF(4), EGFR(4), ELK1(1), ERBB2(3), ERBB3(1), ERBB4(4), GAB1(1), GRB2(1), MAP2K1(2), MAP2K4(1), MAPK8(1), MYC(7), NCK1(2), NRG1(4), NRG2(1), NRG3(2), PAK2(11), PAK4(2), PAK6(3), PAK7(7), PIK3CA(2), PIK3CD(1), PIK3CG(3), PIK3R2(1), PIK3R3(1), PLCG1(3), PLCG2(5), PRKCG(2), PTK2(2), RAF1(4), RPS6KB2(5), SHC2(1), SHC3(1), SOS1(1), SOS2(1) 7626194 115 33 94 169 21 43 10 33 8 0 1.000 1.000 1.000 57 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 120 BRAF(3), CD247(1), CD48(2), CSF2(1), GRB2(1), GZMB(5), HLA-A(93), HLA-B(42), HLA-C(60), HLA-E(1), HLA-G(5), ICAM1(6), IFNA1(2), IFNA10(4), IFNA13(1), IFNA14(2), IFNA16(4), IFNA17(1), IFNA5(1), IFNAR1(4), IFNAR2(3), IFNGR2(2), ITGAL(1), KIR2DL3(2), KIR3DL1(16), KIR3DL2(3), KLRK1(1), LCP2(1), MAP2K1(2), MICA(31), NCR1(1), NCR2(3), NCR3(1), NFAT5(1), NFATC1(6), NFATC2(2), NFATC3(1), NFATC4(1), PIK3CA(2), PIK3CD(1), PIK3CG(3), PIK3R2(1), PIK3R3(1), PLCG1(3), PLCG2(5), PPP3CA(1), PPP3CC(1), PRF1(2), PRKCG(2), PTK2B(4), PTPN6(4), RAC1(1), RAC3(1), RAF1(4), SHC2(1), SHC3(1), SOS1(1), SOS2(1), TNF(3), TNFRSF10A(7), TNFRSF10B(4), TNFRSF10C(7), TNFRSF10D(1), ULBP3(2), VAV1(3), VAV2(3), VAV3(4), ZAP70(1) 8138926 392 33 284 330 56 138 18 147 29 4 1.000 1.000 1.000 58 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 96 ADCY2(7), ADCY3(2), ADCY4(2), ADCY6(1), ADCY8(1), ADCY9(4), CAMK2G(1), CREB3L1(2), CREB3L2(1), CREB3L4(2), CREBBP(7), DCT(1), DVL1(1), EP300(5), FZD1(1), FZD10(1), FZD2(1), FZD3(1), FZD5(2), FZD6(3), FZD7(1), GNAI2(2), GNAS(1), KITLG(1), MAP2K1(2), MC1R(4), MITF(1), PLCB1(8), PLCB3(2), PLCB4(2), POMC(2), PRKACA(1), PRKACG(2), PRKCG(2), PRKX(1), RAF1(4), TCF7(2), TCF7L1(2), TYRP1(1), WNT10A(1), WNT16(4), WNT3A(1), WNT5A(1), WNT7B(1), WNT8B(2), WNT9B(2) 7989402 99 33 86 167 21 33 6 25 14 0 1.000 1.000 1.000 59 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 160 ADORA1(1), ADORA3(4), ADRA1A(3), ADRA1D(2), ADRA2C(1), ADRB1(1), ADRB2(3), AGTR1(2), AGTR2(3), AVPR1B(3), CCKBR(1), CCR1(1), CCR2(3), CCR3(1), CCR6(1), CCR8(5), CCRL2(4), CHML(2), CHRM3(5), CMKLR1(1), CNR2(4), DRD2(1), DRD3(1), DRD5(5), EDNRA(1), F2R(1), F2RL2(1), F2RL3(1), FPR1(8), FSHR(5), GALR1(3), GALR2(1), GALR3(1), GALT(2), GHSR(1), GPR35(1), GPR37L1(1), GPR50(7), GPR63(1), GPR87(2), HCRTR1(2), HCRTR2(2), HRH1(1), HRH2(1), HTR1B(2), HTR1F(3), HTR2A(2), HTR2C(1), HTR4(1), HTR5A(1), HTR7(1), MAS1(1), MC1R(4), MC3R(2), MC5R(1), MTNR1A(2), MTNR1B(2), NMUR1(2), NMUR2(2), NPY2R(1), NTSR2(1), OPRK1(1), OPRM1(2), OR10A5(1), OR11A1(3), OR12D3(5), OR1F1(4), OR1Q1(3), OR2H1(4), OR5V1(4), OR7A5(1), OR7C1(7), OXTR(1), P2RY1(1), P2RY10(1), P2RY11(3), P2RY13(1), P2RY6(1), PTAFR(2), PTGFR(1), PTGIR(2), SSTR1(1), SSTR2(1), SSTR3(1), SSTR4(6) 8605749 187 32 153 247 28 72 12 68 7 0 1.000 1.000 1.000 60 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 89 ACVR1(1), ACVR1C(2), ACVRL1(1), BMP2(2), BMP4(2), BMP5(1), BMP6(1), BMP7(1), BMP8A(1), BMPR1A(3), CDKN2B(1), CHRD(4), COMP(2), CREBBP(7), CUL1(2), EP300(5), GDF5(3), ID3(2), INHBB(1), INHBC(1), INHBE(1), LEFTY1(6), LTBP1(4), MYC(7), NODAL(1), PITX2(1), PPP2CA(1), PPP2R1B(1), PPP2R2B(3), PPP2R2C(1), RBL2(3), RHOA(2), ROCK2(2), RPS6KB2(5), SKP1(1), SMAD3(1), SMAD7(1), SMAD9(3), SMURF1(1), SMURF2(1), SP1(1), TGFB2(1), THBS1(5), THBS2(1), THBS3(2), THBS4(3), TNF(3), ZFYVE9(2) 7290751 107 32 91 118 23 40 3 29 12 0 1.000 1.000 1.000 61 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 72 ACTB(5), ACTN1(3), ACTN2(1), ACTN4(1), ACVR1C(2), CDH1(1), CREBBP(7), CSNK2A1(4), CSNK2B(1), CTNNA2(3), CTNNA3(6), CTNND1(1), EGFR(4), EP300(5), ERBB2(3), FARP2(10), FER(3), INSR(2), LMO7(10), MET(2), MLLT4(1), PARD3(2), PTPN1(1), PTPN6(4), PTPRB(8), PTPRF(1), PTPRJ(6), PTPRM(1), PVRL1(3), PVRL2(1), PVRL4(1), RAC1(1), RAC3(1), RHOA(2), SMAD3(1), SNAI1(2), SORBS1(4), SSX2IP(3), TCF7(2), TCF7L1(2), TJP1(3), WAS(1), WASF1(1), WASF3(3), WASL(1), YES1(1) 8670606 131 32 116 167 28 50 4 36 13 0 1.000 1.000 1.000 62 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 66 ADCY8(1), ATF4(4), BRAF(3), CACNA1C(8), CAMK2G(1), CAMK4(1), CREBBP(7), EP300(5), GRIA2(3), GRIN2A(2), GRIN2B(2), GRIN2C(3), GRIN2D(1), GRM1(2), GRM5(1), ITPR1(4), ITPR2(3), ITPR3(2), MAP2K1(2), PLCB1(8), PLCB3(2), PLCB4(2), PPP1CA(1), PPP1R12A(1), PPP3CA(1), PPP3CC(1), PRKACA(1), PRKACG(2), PRKCG(2), PRKX(1), RAF1(4), RAPGEF3(8), RPS6KA1(2), RPS6KA2(1), RPS6KA6(1) 7533361 93 32 82 187 23 22 4 29 15 0 1.000 1.000 1.000 63 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 82 AGRN(4), CD36(1), CD44(3), CHAD(1), COL11A1(7), COL11A2(5), COL1A2(1), COL2A1(3), COL3A1(7), COL4A1(3), COL4A2(5), COL4A4(11), COL5A1(5), COL5A2(5), COL5A3(12), COL6A1(5), COL6A2(6), COL6A6(4), FN1(2), FNDC1(8), FNDC3A(2), FNDC4(1), GP6(2), GP9(1), HSPG2(15), IBSP(5), ITGA1(3), ITGA10(5), ITGA11(7), ITGA2(1), ITGA2B(2), ITGA3(1), ITGA4(5), ITGA5(2), ITGA6(4), ITGA7(1), ITGA8(1), ITGA9(2), ITGB3(3), ITGB4(2), LAMA1(26), LAMA2(8), LAMA3(6), LAMA4(5), LAMB1(2), LAMB2(5), LAMB3(4), LAMB4(5), LAMC1(4), LAMC2(3), LAMC3(6), RELN(9), SDC3(5), SDC4(5), SPP1(1), SV2B(2), SV2C(3), THBS1(5), THBS2(1), THBS3(2), THBS4(3), TNC(10), TNN(10), TNR(4), TNXB(14), VTN(2), VWF(11) 15848647 324 31 255 467 105 100 20 73 23 3 1.000 1.000 1.000 64 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 137 ADCY2(7), ADCY3(2), ADCY4(2), ADCY6(1), ADCY8(1), ADCY9(4), ADRA1A(3), ADRA1D(2), ADRB1(1), ADRB2(3), ATP1A4(1), ATP2A3(2), CACNA1A(3), CACNA1B(7), CACNA1C(8), CACNA1E(5), CACNA1S(8), CALR(1), CAMK2G(1), CAMK4(1), CASQ1(1), CHRM3(5), GJA1(1), GJA4(5), GJB3(1), GJB4(3), GNAI2(2), GNB3(1), GNGT1(1), GRK4(6), GRK5(2), GRK6(1), ITPR1(4), ITPR2(3), ITPR3(2), KCNB1(1), KCNJ3(1), KCNJ5(1), PLCB3(2), PRKACA(1), PRKCD(1), PRKCG(2), PRKCQ(2), PRKD1(3), RGS1(1), RGS11(3), RGS14(2), RGS18(2), RGS3(4), RGS6(1), RGS7(1), RGS9(1), RYR1(4), RYR2(9), RYR3(6), SFN(2), SLC8A1(1), SLC8A3(1) 14128741 153 30 127 357 42 51 7 34 18 1 1.000 1.000 1.000 65 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 81 AGL(6), AMY2A(1), AMY2B(2), ASCC3(5), ATP13A2(1), DDX18(2), DDX23(1), DDX41(2), DDX47(2), DDX51(6), DDX52(4), DDX54(2), DDX55(3), DHX58(5), ENPP1(3), ENPP3(3), ENTPD7(3), EP400(7), ERCC2(4), G6PC2(6), GAA(1), GANC(5), GBA(2), GBE1(3), GUSB(1), GYS2(2), HK1(1), HK2(4), HK3(1), IFIH1(7), LYZL1(1), MGAM(12), MOV10L1(17), NUDT5(1), PGM1(4), PGM3(1), PYGB(6), PYGL(4), RAD54B(2), SETX(8), SI(5), SKIV2L2(2), SMARCA2(8), SMARCA5(1), UGT1A1(2), UGT1A10(1), UGT1A3(4), UGT1A4(1), UGT1A6(7), UGT1A7(6), UGT1A9(3), UGT2B15(3), UGT2B17(2), UGT2B28(8), UGT2B4(2), UGT2B7(4), UXS1(1) 9565232 211 30 153 226 36 69 12 74 20 0 1.000 1.000 1.000 66 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 64 CALR(1), CANX(1), CD8B(5), CIITA(10), CTSS(2), HLA-A(93), HLA-B(42), HLA-C(60), HLA-DMA(4), HLA-DMB(1), HLA-DOB(1), HLA-DPA1(29), HLA-DQA1(19), HLA-DQA2(8), HLA-DQB1(30), HLA-DRA(2), HLA-DRB1(46), HLA-E(1), HLA-G(5), HSP90AA1(2), IFI30(2), IFNA1(2), IFNA10(4), IFNA13(1), IFNA14(2), IFNA16(4), IFNA17(1), IFNA5(1), KIR2DL3(2), KIR3DL1(16), KIR3DL2(3), KIR3DL3(3), LGMN(1), NFYA(1), NFYC(2), PDIA3(1), RFX5(4), RFXANK(2), RFXAP(1), TAP1(5), TAP2(5) 3096880 425 30 294 270 57 152 19 166 28 3 1.000 1.000 1.000 67 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 90 AKT2(1), BCL10(2), CBL(1), CBLB(1), CBLC(5), CD247(1), CD3D(1), CD3G(2), CD8B(5), CHUK(1), CSF2(1), CTLA4(1), GRAP2(1), GRB2(1), IKBKB(2), LCP2(1), MALT1(1), NCK1(2), NFAT5(1), NFATC1(6), NFATC2(2), NFATC3(1), NFATC4(1), NFKB1(3), NFKB2(3), NFKBIA(3), NFKBIB(1), PAK2(11), PAK4(2), PAK6(3), PAK7(7), PIK3CA(2), PIK3CD(1), PIK3CG(3), PIK3R2(1), PIK3R3(1), PLCG1(3), PPP3CA(1), PPP3CC(1), PRKCQ(2), PTPN6(4), PTPRC(1), RHOA(2), SOS1(1), SOS2(1), TEC(2), TNF(3), VAV1(3), VAV2(3), VAV3(4), ZAP70(1) 7285366 114 30 94 148 28 35 5 30 16 0 1.000 1.000 1.000 68 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 84 BRAF(3), CHUK(1), ELK1(1), GRB2(1), IKBKB(2), MAP2K1(2), MAP2K3(4), MAP2K4(1), MAP3K1(7), MAP3K10(1), MAP3K11(1), MAP3K13(1), MAP3K4(1), MAP3K5(1), MAP3K6(5), MAP4K1(1), MAP4K3(2), MAP4K4(1), MAP4K5(3), MAPK11(1), MAPK4(1), MAPK7(1), MAPK8(1), MAPKAPK2(1), MAPKAPK5(2), MEF2B(3), MEF2C(1), MKNK1(1), MKNK2(3), MYC(7), NFKB1(3), NFKBIA(3), PAK2(11), RAC1(1), RAF1(4), RPS6KA1(2), RPS6KA2(1), RPS6KA5(1), RPS6KB2(5), SP1(1), STAT1(1), TGFB2(1) 7240715 95 30 80 132 16 29 9 29 12 0 1.000 1.000 1.000 69 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 136 ADCY2(7), ADCY3(2), ADCY4(2), ADCY6(1), ADCY8(1), ADCY9(4), ATF1(1), ATF4(4), ATF5(2), ATP2A3(2), CALCA(1), CAMK2G(1), CNN1(1), CRHR1(1), DGKZ(4), ETS2(2), GABPB2(1), GBA2(1), GJA1(1), GNB3(1), GNGT1(1), GRK4(6), GRK5(2), GRK6(1), GUCA2A(2), GUCA2B(1), GUCY1A3(1), IGFBP1(2), IGFBP3(1), IGFBP4(1), IL6(2), ITPR1(4), ITPR2(3), ITPR3(2), NFKB1(3), NOS1(3), OXTR(1), PLCB3(2), PLCD1(2), PLCG1(3), PLCG2(5), PRKACA(1), PRKCD(1), PRKCQ(2), PRKD1(3), RAMP3(1), RGS1(1), RGS11(3), RGS14(2), RGS18(2), RGS3(4), RGS6(1), RGS7(1), RGS9(1), RYR1(4), RYR2(9), RYR3(6), SFN(2), SLC8A1(1), SP1(1), TNXB(14) 13015171 148 30 125 337 38 60 7 30 12 1 1.000 1.000 1.000 70 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 78 ABL1(3), ACTN1(3), AKT2(1), ANGPTL2(1), BCAR1(2), BRAF(3), CAV1(1), CDKN2A(1), DOCK1(7), EPHB2(1), GRB2(1), ILK(1), ITGA1(3), ITGA10(5), ITGA11(7), ITGA2(1), ITGA3(1), ITGA4(5), ITGA5(2), ITGA6(4), ITGA7(1), ITGA8(1), ITGA9(2), MAP2K4(1), MAP3K11(1), MAPK8(1), MAPK8IP1(2), MAPK8IP3(2), MYLK(8), PAK2(11), PAK4(2), PAK6(3), PAK7(7), PIK3CA(2), PLCG1(3), PLCG2(5), PTEN(2), PTK2(2), RAF1(4), ROCK2(2), SOS1(1), SOS2(1), TERF2IP(1), TLN1(6), TLN2(6), WAS(1) 9117849 131 30 104 182 34 43 12 32 9 1 1.000 1.000 1.000 71 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 42 ABCA1(8), ABCA10(3), ABCA12(3), ABCA13(31), ABCA2(3), ABCA3(4), ABCA4(8), ABCA5(3), ABCA7(14), ABCA8(9), ABCA9(1), ABCB1(6), ABCB10(1), ABCB11(2), ABCB5(15), ABCB6(1), ABCB8(6), ABCB9(1), ABCC1(3), ABCC10(2), ABCC11(4), ABCC12(7), ABCC2(4), ABCC3(5), ABCC4(2), ABCC6(12), ABCC8(1), ABCD2(1), ABCD4(6), ABCG2(3), ABCG4(3), ABCG8(5), CFTR(5), TAP1(5), TAP2(5) 8547992 192 29 148 178 51 63 7 50 21 0 1.000 1.000 1.000 72 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 59 AKT2(1), BCL10(2), BTK(2), CD19(2), CD22(2), CD72(2), CD79A(2), CHUK(1), CR2(7), FCGR2B(1), IKBKB(2), LILRB3(34), LYN(2), MALT1(1), NFAT5(1), NFATC1(6), NFATC2(2), NFATC3(1), NFATC4(1), NFKB1(3), NFKB2(3), NFKBIA(3), NFKBIB(1), PIK3CA(2), PIK3CD(1), PIK3CG(3), PIK3R2(1), PIK3R3(1), PLCG2(5), PPP3CA(1), PPP3CC(1), PTPN6(4), RAC1(1), RAC3(1), VAV1(3), VAV2(3), VAV3(4) 5268389 113 29 89 124 21 41 3 33 15 0 1.000 1.000 1.000 73 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 89 BCAR1(2), CAPN10(1), CAPN11(5), CAPN2(4), CAPN3(1), CAPN6(1), CAPN7(1), CAPN9(7), CAV1(1), CAV2(2), CSK(3), DOCK1(7), GIT2(2), GRB2(1), ILK(1), ITGA10(5), ITGA11(7), ITGA2(1), ITGA2B(2), ITGA3(1), ITGA4(5), ITGA5(2), ITGA6(4), ITGA7(1), ITGA8(1), ITGA9(2), ITGAD(2), ITGAE(8), ITGAL(1), ITGAM(6), ITGAX(6), ITGB3(3), ITGB4(2), MAP2K1(2), MAP2K3(4), MAPK4(1), MAPK7(1), PAK2(11), PAK4(2), PAK6(3), PDPK1(1), PIK3R2(1), PTK2(2), RAC1(1), RAC3(1), RAPGEF1(1), ROCK2(2), SDCCAG8(2), SHC3(1), SORBS1(4), SOS1(1), TLN1(6), TNS1(15), VAV2(3), VAV3(4) 10052147 167 29 125 248 50 49 11 44 12 1 1.000 1.000 1.000 74 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 43 CBL(1), CD3D(1), CSK(3), CTLA4(1), EPHB2(1), GRAP2(1), GRB2(1), ITPKA(1), ITPKB(10), LCP2(1), NCK1(2), NFAT5(1), NFKB1(3), NFKB2(3), NFKBIA(3), NFKBIB(1), PAK2(11), PAK4(2), PAK6(3), PAK7(7), PLCG1(3), PTPRC(1), RAF1(4), RASGRP4(1), SOS1(1), SOS2(1), VAV1(3), ZAP70(1) 4182020 72 29 55 66 16 26 6 16 8 0 1.000 1.000 1.000 75 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 42 ADAM17(1), CREBBP(7), DLL3(1), DTX1(4), DTX2(2), DTX3L(3), DTX4(2), DVL1(1), EP300(5), HDAC2(2), JAG1(3), JAG2(4), LFNG(1), MAML1(4), MAML2(3), NCOR2(9), NOTCH1(2), NOTCH2(10), NOTCH3(5), NOTCH4(10), NUMB(2), NUMBL(1), PSEN1(1), PTCRA(6), RBPJL(6) 5249524 95 28 76 109 22 29 1 29 14 0 1.000 1.000 1.000 76 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 81 ANPEP(4), CD19(2), CD1A(2), CD1B(1), CD1C(2), CD1D(1), CD1E(3), CD2(1), CD22(2), CD36(1), CD3D(1), CD3G(2), CD44(3), CD5(3), CD8B(5), CR2(7), CSF1(2), CSF2(1), CSF2RA(2), CSF3R(2), EPOR(1), FCER2(3), FLT3(1), FLT3LG(1), GP9(1), HLA-DRA(2), HLA-DRB1(46), IL11(1), IL1A(2), IL1R1(1), IL1R2(1), IL2RA(1), IL3(3), IL3RA(4), IL4R(15), IL5RA(2), IL6(2), IL6R(2), IL7R(7), IL9R(2), ITGA1(3), ITGA2(1), ITGA2B(2), ITGA3(1), ITGA4(5), ITGA5(2), ITGA6(4), ITGAM(6), ITGB3(3), KITLG(1), MME(4), TFRC(2), TNF(3), TPO(10) 5718041 192 28 145 168 33 79 14 54 11 1 1.000 1.000 1.000 77 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 128 ACACA(2), ACACB(12), AKT2(1), BRAF(3), CBL(1), CBLB(1), CBLC(5), ELK1(1), EXOC7(2), FASN(3), FBP2(2), FOXO1(2), G6PC2(6), GRB2(1), GYS2(2), IKBKB(2), INSR(2), IRS1(2), IRS2(2), IRS4(6), LIPE(2), MAP2K1(2), MAPK8(1), MKNK1(1), MKNK2(3), PCK1(3), PCK2(1), PDPK1(1), PFKM(1), PHKA1(1), PHKB(2), PIK3CA(2), PIK3CD(1), PIK3CG(3), PIK3R2(1), PIK3R3(1), PPARGC1A(2), PPP1CA(1), PRKAA1(1), PRKACA(1), PRKACG(2), PRKAG3(4), PRKX(1), PTPN1(1), PTPRF(1), PYGB(6), PYGL(4), RAF1(4), RAPGEF1(1), RPS6KB2(5), SHC2(1), SHC3(1), SLC2A4(1), SOCS1(9), SOCS3(1), SORBS1(4), SOS1(1), SOS2(1), SREBF1(1), TRIP10(1), TSC1(4) 11725086 143 28 120 274 39 55 4 30 15 0 1.000 1.000 1.000 78 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 66 ADAM10(1), ADAM17(1), ATP6V0A1(2), ATP6V0A2(2), ATP6V0A4(1), ATP6V0B(1), ATP6V0D2(1), ATP6V1A(1), ATP6V1B1(2), ATP6V1C2(2), ATP6V1G3(1), ATP6V1H(1), CHUK(1), CSK(3), EGFR(4), IGSF5(4), IKBKB(2), LYN(2), MAP2K4(1), MAPK11(1), MAPK8(1), MET(2), NFKB1(3), NFKB2(3), NFKBIA(3), NOD1(3), PLCG1(3), PLCG2(5), PTPRZ1(13), RAC1(1), TCIRG1(2), TJP1(3) 5259254 76 28 64 95 23 18 7 17 11 0 1.000 1.000 1.000 79 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 63 AKT2(1), CDKN1B(1), CDKN2A(1), ERBB4(4), F2RL2(1), GAB1(1), GRB2(1), IGFBP1(2), INPPL1(1), IRS1(2), IRS2(2), IRS4(6), MET(2), MYC(7), NOLC1(2), PAK2(11), PAK4(2), PAK6(3), PAK7(7), PARD3(2), PIK3CA(2), PIK3CD(1), PREX1(8), PTEN(2), PTK2(2), PTPN1(1), RPS6KA1(2), RPS6KA2(1), SFN(2), SLC2A4(1), SOS1(1), SOS2(1), TSC1(4), YWHAE(1) 5630802 88 28 68 130 15 29 6 29 9 0 1.000 1.000 1.000 80 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 90 ADCY2(7), ADCY3(2), ADCY4(2), ADCY6(1), ADCY8(1), ADCY9(4), AKAP1(4), AKAP10(3), AKAP11(5), AKAP12(10), AKAP2(5), AKAP3(4), AKAP4(3), AKAP5(2), AKAP6(8), AKAP7(3), AKAP9(8), ARHGEF1(1), GNA13(2), GNA14(1), GNAI2(2), GNB3(1), GNGT1(1), IL18BP(1), ITPR1(4), KCNJ3(1), PALM2(1), PDE1B(1), PDE1C(5), PDE4A(3), PDE4C(2), PLCB3(2), PPP3CA(1), PPP3CC(1), PRKACA(1), PRKACG(2), PRKCD(1), PRKCG(2), PRKCQ(2), PRKD1(3), PRKD3(2), RHOA(2) 8544817 117 27 102 182 27 48 5 29 7 1 1.000 1.000 1.000 81 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 52 ADORA3(4), ALG6(4), CCKBR(1), CCR2(3), CCR3(1), CELSR1(21), CELSR2(1), CELSR3(3), CHRM3(5), CIDEB(1), EDNRA(1), EMR2(4), EMR3(4), F2R(1), FSHR(5), GHRHR(2), GPR116(5), GPR133(4), GPR18(1), GPR55(3), GPR56(4), GRM1(2), HRH4(3), LGR6(3), LPHN2(3), LPHN3(1), P2RY11(3), P2RY13(1), PTGFR(1), SMO(2), SSTR2(1), TSHR(3) 4857309 101 27 81 109 21 35 7 37 1 0 1.000 1.000 1.000 82 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 107 ABL1(3), ANAPC1(3), ANAPC4(3), ATM(8), ATR(6), BUB1(1), BUB1B(1), CCNA1(1), CCNB2(2), CCNB3(1), CCND1(1), CCND2(2), CCND3(3), CDC14A(1), CDC16(3), CDC25C(4), CDC6(5), CDKN1A(4), CDKN1B(1), CDKN2A(1), CDKN2B(1), CHEK2(2), CREBBP(7), CUL1(2), DBF4(2), E2F1(2), E2F2(3), E2F3(1), EP300(5), ESPL1(12), FZR1(1), HDAC2(2), MAD1L1(3), MAD2L1(1), MCM3(2), MCM4(2), MCM7(2), PKMYT1(2), PLK1(1), RB1(1), RBL2(3), SFN(2), SKP1(1), SKP2(1), SMAD3(1), SMC1B(8), TGFB2(1), YWHAE(1) 9829778 126 27 101 124 32 44 2 32 14 2 1.000 1.000 1.000 83 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 67 A2M(4), C1S(4), C3(5), C4A(6), C4B(2), C4BPA(4), C5(6), C6(3), C7(7), C8A(9), C8B(3), C9(2), CFB(2), CFH(4), CFI(2), CPB2(2), CR2(7), F10(1), F11(1), F12(1), F13A1(8), F13B(1), F2(1), F2R(1), F5(18), F7(3), F8(3), F9(1), FGA(2), FGB(1), FGG(1), KLKB1(4), KNG1(6), MASP1(1), MASP2(4), MBL2(4), PLAT(1), PLG(4), PROC(2), PROS1(1), SERPINA1(3), SERPINA5(6), SERPINC1(1), SERPIND1(2), SERPINE1(1), SERPINF2(8), SERPING1(1), THBD(1), VWF(11) 7331727 176 27 130 166 42 81 0 45 8 0 1.000 1.000 1.000 84 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 46 IMPA2(1), INPP4A(3), INPP4B(5), INPP5A(2), INPP5B(4), INPPL1(1), ITPKA(1), ITPKB(10), OCRL(1), PI4KA(4), PIK3C3(1), PIK3CA(2), PIK3CD(1), PIK3CG(3), PIP5K1A(1), PIP5K1B(1), PIP5K1C(2), PLCB1(8), PLCB3(2), PLCB4(2), PLCD1(2), PLCD4(2), PLCE1(8), PLCG1(3), PLCG2(5), PTEN(2), SYNJ1(2), SYNJ2(3) 5487270 82 26 70 136 17 26 6 18 15 0 1.000 1.000 1.000 85 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 106 A4GNT(2), ALG1(6), ALG10(1), ALG11(1), ALG12(1), ALG14(2), ALG3(1), ALG6(4), ALG8(3), ALG9(1), B3GNT1(1), B3GNT6(1), B3GNT7(2), B4GALT2(1), B4GALT3(2), B4GALT4(1), B4GALT5(1), C1GALT1C1(1), CHST11(1), CHST12(4), CHST13(2), CHST2(1), CHST4(2), CHST6(1), CHSY1(3), DPAGT1(2), EXT1(1), EXT2(1), EXTL1(2), EXTL3(1), FUT8(4), GALNT1(1), GALNT10(1), GALNT12(1), GALNT2(2), GALNT4(5), GALNT5(1), GALNT6(1), GALNT8(8), GALNT9(1), GANAB(3), GCNT1(4), GCNT4(2), HS3ST1(1), HS3ST3B1(1), HS3ST5(1), HS6ST1(3), HS6ST2(1), HS6ST3(2), MAN1A2(1), MAN1B1(1), MAN1C1(1), MAN2A1(1), MGAT1(6), MGAT4A(2), MGAT5(1), MGAT5B(2), NDST1(1), NDST3(1), RPN2(1), ST6GAL1(3), ST6GALNAC1(3), STT3B(1), UST(1), WBSCR17(1), XYLT1(4), XYLT2(5) 8073853 132 26 110 171 27 48 5 46 6 0 1.000 1.000 1.000 86 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 78 AKT2(1), ATM(8), BCL2(1), BIRC2(1), CAPN2(4), CASP10(2), CASP7(3), CASP8(3), CASP9(4), CHUK(1), CSF2RB(3), DFFA(1), ENDOG(2), IKBKB(2), IL1A(2), IL1R1(1), IL3(3), IL3RA(4), IRAK1(3), IRAK2(5), IRAK3(1), NFKB1(3), NFKB2(3), NFKBIA(3), NTRK1(3), PIK3CA(2), PIK3CD(1), PIK3CG(3), PIK3R2(1), PIK3R3(1), PPP3CA(1), PPP3CC(1), PRKACA(1), PRKACG(2), TNF(3), TNFRSF10A(7), TNFRSF10B(4), TNFRSF10C(7), TNFRSF10D(1) 6035336 102 26 77 113 16 39 1 37 9 0 1.000 1.000 1.000 87 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 27 BRAF(3), CPEB1(1), EGFR(4), ERBB2(3), ERBB4(4), ETS1(1), ETS2(2), ETV6(1), ETV7(2), FMN2(14), GRB2(1), MAP2K1(2), NOTCH1(2), NOTCH2(10), NOTCH3(5), NOTCH4(10), PIWIL1(4), PIWIL3(2), PIWIL4(6), RAF1(4), SOS1(1), SOS2(1), SPIRE2(1) 3884971 84 26 63 97 15 32 2 27 7 1 1.000 1.000 1.000 88 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 89 ADCY2(7), ADCY3(2), ADCY4(2), ADCY6(1), ADCY8(1), ADCY9(4), ADRB1(1), DRD2(1), EGF(4), EGFR(4), GJA1(1), GJD2(1), GNAI2(2), GNAS(1), GRB2(1), GRM1(2), GRM5(1), GUCY1A2(2), GUCY1A3(1), GUCY2D(5), HTR2A(2), HTR2C(1), ITPR1(4), ITPR2(3), ITPR3(2), MAP2K1(2), MAPK7(1), NPR1(2), NPR2(1), PDGFC(1), PDGFRB(2), PLCB1(8), PLCB3(2), PLCB4(2), PRKACA(1), PRKACG(2), PRKCG(2), PRKG1(3), PRKG2(1), PRKX(1), RAF1(4), SOS1(1), SOS2(1), TJP1(3), TUBA1B(1), TUBA1C(1), TUBA3C(3), TUBA3E(8), TUBA8(3), TUBAL3(1), TUBB1(4), TUBB2A(1), TUBB6(2), TUBB8(5) 9600654 125 26 107 243 35 41 3 29 17 0 1.000 1.000 1.000 89 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 105 ACTN1(3), ACTN2(1), ACTN4(1), ARHGAP5(2), BCAR1(2), CD99(3), CLDN18(1), CLDN22(2), CLDN5(2), CTNNA2(3), CTNNA3(6), CTNND1(1), CYBA(1), CYBB(1), EZR(1), GNAI2(2), ICAM1(6), ITGA4(5), ITGAL(1), ITGAM(6), MAPK11(1), MLLT4(1), MMP2(1), MMP9(3), MSN(2), NCF1(1), NCF2(2), NOX3(2), PIK3CA(2), PIK3CD(1), PIK3CG(3), PIK3R2(1), PIK3R3(1), PLCG1(3), PLCG2(5), PRKCG(2), PTK2(2), PTK2B(4), RAC1(1), RAPGEF3(8), RHOA(2), ROCK2(2), SIPA1(3), TXK(4), VAV1(3), VAV2(3), VAV3(4), VCAM1(1) 9036327 118 26 94 182 31 28 9 32 17 1 1.000 1.000 1.000 90 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 72 BRAF(3), CACNA1A(3), CRHR1(1), GNA13(2), GNAI2(2), GNAS(1), GRIA2(3), GRID2(5), GRM1(2), GRM5(1), GUCY1A2(2), GUCY1A3(1), GUCY2D(5), ITPR1(4), ITPR2(3), ITPR3(2), LYN(2), MAP2K1(2), NOS1(3), NPR1(2), NPR2(1), PLA2G2D(1), PLA2G3(4), PLA2G4A(1), PLA2G5(1), PLCB1(8), PLCB3(2), PLCB4(2), PPP2CA(1), PPP2R1B(1), PPP2R2B(3), PPP2R2C(1), PRKCG(2), PRKG1(3), PRKG2(1), RAF1(4), RYR1(4) 8102911 89 26 81 204 25 26 4 21 13 0 1.000 1.000 1.000 91 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 94 ADCY2(7), ADCY3(2), ADCY4(2), ADCY6(1), ADCY8(1), ADCY9(4), ATF4(4), CACNA1C(8), CACNA1F(6), CACNA1S(8), CAMK2G(1), EGFR(4), ELK1(1), GNAS(1), GNRH1(3), GNRH2(2), GRB2(1), ITPR1(4), ITPR2(3), ITPR3(2), LHB(3), MAP2K1(2), MAP2K3(4), MAP2K4(1), MAP3K1(7), MAP3K4(1), MAPK11(1), MAPK7(1), MAPK8(1), MMP14(4), MMP2(1), PLA2G2D(1), PLA2G3(4), PLA2G4A(1), PLA2G5(1), PLCB1(8), PLCB3(2), PLCB4(2), PLD1(4), PLD2(13), PRKACA(1), PRKACG(2), PRKCD(1), PRKX(1), PTK2B(4), RAF1(4), SOS1(1), SOS2(1) 9645542 142 26 115 240 35 44 9 32 22 0 1.000 1.000 1.000 92 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 37 AKT2(1), BCR(1), BTK(2), CD19(2), CSK(3), EPHB2(1), GRB2(1), ITPKA(1), ITPKB(10), LYN(2), MAP2K1(2), NFAT5(1), NFKB1(3), NFKB2(3), NFKBIA(3), NFKBIB(1), PIK3CA(2), PIK3CD(1), PLCG2(5), RAF1(4), SOS1(1), SOS2(1), VAV1(3) 3844130 54 26 49 87 16 15 2 11 10 0 1.000 1.000 1.000 93 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 57 BFAR(4), BTK(2), CAD(1), CASP10(2), CASP8(3), CSNK1A1(2), DFFA(1), EGFR(4), EPHB2(1), FAF1(1), IL1A(2), MAP2K4(1), MAP3K1(7), MAP3K5(1), MAPK8(1), MAPK8IP1(2), MAPK8IP3(2), MET(2), NFAT5(1), NFKB1(3), NFKB2(3), NFKBIA(3), NFKBIB(1), PFN1(3), PTPN13(8), RALBP1(1), TNFRSF6B(1), TPX2(1), TUFM(1) 5411995 65 26 57 95 14 22 3 18 8 0 1.000 1.000 1.000 94 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 139 ADCY2(7), ADCY3(2), ADCY4(2), ADCY6(1), ADCY8(1), ADCY9(4), ADSS(1), ADSSL1(3), AK1(1), AK2(2), AK5(1), AK7(3), AMPD3(3), ATIC(1), DCK(1), ENPP1(3), ENPP3(3), ENTPD2(1), ENTPD3(3), ENTPD4(2), ENTPD5(2), ENTPD6(4), GART(3), GDA(2), GMPR(1), GMPS(1), GUCY1A2(2), GUCY1A3(1), GUCY2D(5), NPR1(2), NPR2(1), NT5C(1), NT5C1B(2), NT5C2(1), NT5E(2), NT5M(1), NUDT5(1), NUDT9(1), PAICS(2), PAPSS1(5), PAPSS2(1), PDE10A(1), PDE11A(3), PDE1C(5), PDE2A(1), PDE4A(3), PDE4C(2), PDE5A(2), PDE6H(1), PDE9A(4), PFAS(6), POLA2(1), POLD1(2), POLD3(1), POLD4(1), POLE(4), POLE4(2), POLR1A(3), POLR1B(2), POLR2B(1), POLR2E(1), POLR3A(4), PRIM1(1), PRPS1L1(2), PRUNE(1), RFC5(1), RRM1(1), XDH(6) 11828384 148 25 120 255 41 46 6 45 10 0 1.000 1.000 1.000 95 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 95 AKT2(1), CASP8(3), CD80(2), CD86(1), CHUK(1), IFNA1(2), IFNA10(4), IFNA13(1), IFNA14(2), IFNA16(4), IFNA17(1), IFNA5(1), IFNAR1(4), IFNAR2(3), IKBKB(2), IKBKE(4), IL12B(2), IL6(2), IRAK1(3), IRF3(3), IRF5(1), IRF7(2), LBP(8), MAP2K1(2), MAP2K3(4), MAP2K4(1), MAPK11(1), MAPK8(1), NFKB1(3), NFKB2(3), NFKBIA(3), PIK3CA(2), PIK3CD(1), PIK3CG(3), PIK3R2(1), PIK3R3(1), RAC1(1), SPP1(1), STAT1(1), TIRAP(5), TLR1(5), TLR2(2), TLR3(2), TLR4(2), TLR5(4), TLR6(1), TLR7(1), TLR8(2), TNF(3), TRAF3(4), TRAF6(1) 6483650 118 25 100 135 26 43 8 31 10 0 1.000 1.000 1.000 96 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 INPP4A(3), INPP4B(5), INPP5A(2), INPPL1(1), ITPKA(1), ITPKB(10), OCRL(1), PIK3C2A(3), PIK3C2B(1), PIK3C2G(10), PIK3CA(2), PIK3CG(3), PLCB1(8), PLCB3(2), PLCB4(2), PLCD1(2), PLCG1(3), PLCG2(5) 3347357 64 25 53 98 15 14 4 18 13 0 1.000 1.000 1.000 97 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT2(1), BCL2(1), BCR(1), BTK(2), CD19(2), CD22(2), CR2(7), CSK(3), GRB2(1), ITPR1(4), ITPR2(3), ITPR3(2), LYN(2), MAP4K1(1), NFATC1(6), NFATC2(2), PIK3CA(2), PIK3CD(1), PLCG2(5), PPP3CA(1), PPP3CC(1), PTPRC(1), RAF1(4), SOS1(1), SOS2(1), VAV1(3) 5419191 60 25 54 132 13 22 1 15 9 0 1.000 1.000 1.000 98 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 32 AKT2(1), ASAH1(4), BRAF(3), DRD2(1), EGFR(4), EPHB2(1), GRB2(1), ITPKA(1), ITPKB(10), ITPR1(4), ITPR2(3), ITPR3(2), KCNJ3(1), KCNJ5(1), KCNJ9(2), PITX2(1), PLCB1(8), PLCB3(2), PLCB4(2), RAF1(4), SOS1(1), SOS2(1), TERF2IP(1) 4183555 59 25 50 103 14 22 1 11 11 0 1.000 1.000 1.000 99 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 BTK(2), ELK1(1), GRB2(1), LYN(2), MAP2K1(2), MAP2K4(1), MAP3K1(7), MAPK8(1), NFATC1(6), NFATC2(2), NFATC3(1), NFATC4(1), PAK2(11), PIK3CA(2), PLA2G4A(1), PLCG1(3), PPP3CA(1), PPP3CC(1), RAF1(4), SOS1(1), VAV1(3) 3140558 54 24 42 63 8 17 8 16 5 0 1.000 1.000 1.000 100 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 51 AKR1C4(4), ARSE(1), CYP11B1(3), CYP11B2(5), HEMK1(1), HSD17B1(2), HSD17B12(2), HSD17B7(4), HSD3B1(2), HSD3B2(2), LCMT1(1), LCMT2(1), METTL2B(3), PRMT2(1), PRMT6(2), PRMT8(1), SULT2B1(3), UGT1A1(2), UGT1A10(1), UGT1A3(4), UGT1A4(1), UGT1A6(7), UGT1A7(6), UGT1A9(3), UGT2B15(3), UGT2B17(2), UGT2B28(8), UGT2B4(2), UGT2B7(4) 3291694 81 24 59 92 16 29 3 28 5 0 1.000 1.000 1.000 101 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 72 AKT2(1), BTK(2), CSF2(1), GRB2(1), IL3(3), LCP2(1), LYN(2), MAP2K1(2), MAP2K3(4), MAP2K4(1), MAPK11(1), MAPK8(1), PIK3CA(2), PIK3CD(1), PIK3CG(3), PIK3R2(1), PIK3R3(1), PLA2G2D(1), PLA2G3(4), PLA2G4A(1), PLA2G5(1), PLCG1(3), PLCG2(5), PRKCD(1), RAC1(1), RAC3(1), RAF1(4), SOS1(1), SOS2(1), TNF(3), VAV1(3), VAV2(3), VAV3(4) 5223246 65 24 59 129 14 24 7 13 7 0 1.000 1.000 1.000 102 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 69 ACACB(12), ACSL3(2), ACSL5(2), ADIPOQ(2), ADIPOR2(1), AKT2(1), CAMKK1(1), CAMKK2(5), CD36(1), CHUK(1), CPT1B(4), CPT1C(1), CPT2(5), G6PC2(6), IKBKB(2), IRS1(2), IRS2(2), IRS4(6), JAK1(2), JAK2(2), JAK3(2), LEPR(10), MAPK8(1), NFKB1(3), NFKB2(3), NFKBIA(3), NFKBIB(1), NPY(1), PCK1(3), PCK2(1), POMC(2), PPARA(1), PPARGC1A(2), PRKAA1(1), PRKAG3(4), PRKCQ(2), SLC2A4(1), SOCS3(1), STK11(1), TNF(3), TNFRSF1B(3), TYK2(3) 6035220 112 24 84 148 32 32 10 29 9 0 1.000 1.000 1.000 103 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 51 AGT(4), CALR(1), CAMK1G(1), CAMK4(1), CREBBP(7), CSNK1A1(2), ELSPBP1(11), F2(1), GATA4(2), MAP2K1(2), MAPK8(1), MEF2C(1), MYH2(2), NFATC1(6), NFATC2(2), NFATC3(1), NFATC4(1), NKX2-5(1), NPPA(1), PIK3CA(2), PPP3CA(1), PPP3CC(1), PRKACG(2), RAF1(4) 3689530 58 24 46 65 24 12 4 13 5 0 1.000 1.000 1.000 104 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 50 ACOX1(7), APOA1(1), CD36(1), CPT1B(4), CREBBP(7), EHHADH(3), EP300(5), FABP1(2), HSD17B4(4), LPL(1), MYC(7), NCOA1(2), NCOR1(5), NCOR2(9), NFKBIA(3), NRIP1(3), PIK3CA(2), PPARA(1), PRKACG(2), PTGS2(1), RB1(1), SP1(1), TNF(3) 4739156 75 24 68 75 12 28 3 24 8 0 1.000 1.000 1.000 105 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 44 AKT2(1), ANGPTL2(1), ARHGAP4(2), ARHGEF11(4), BTK(2), GDI1(1), INPPL1(1), ITPR1(4), ITPR2(3), ITPR3(2), LIMK1(1), MYLK(8), PAK2(11), PAK4(2), PAK6(3), PAK7(7), PIK3CA(2), PIK3CD(1), PIK3CG(3), PITX2(1), PTEN(2), RACGAP1(1), ROCK2(2), SAG(5), WASF1(1), WASL(1) 5210714 72 24 56 103 20 18 7 23 4 0 1.000 1.000 1.000 106 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 34 ANGPTL2(1), FLNA(4), FLNC(7), GDI1(1), LIMK1(1), MYH2(2), MYLK(8), PAK2(11), PAK4(2), PAK6(3), PAK7(7), PFN1(3), ROCK2(2), WASF1(1), WASL(1) 3516548 54 24 39 64 12 13 6 21 2 0 1.000 1.000 1.000 107 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 42 ASAH1(4), ATF1(1), BRAF(3), CREBBP(7), EGR1(1), EGR2(1), EGR4(1), ELK1(1), MAP1B(4), MAP2K4(1), MAPK8(1), MAPK8IP1(2), MAPK8IP3(2), NTRK1(3), OPN1LW(7), PIK3C2G(10), PIK3CA(2), PIK3CD(1), TERF2IP(1), TH(3) 3905858 56 24 48 62 13 22 2 14 5 0 1.000 1.000 1.000 108 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTN2(1), ACTN4(1), DES(2), DMD(8), MYBPC1(3), MYBPC2(10), MYBPC3(4), MYH3(1), MYH6(6), MYH7(1), MYH8(5), MYOM1(13), NEB(16), TMOD1(1), TNNT1(1), TPM1(1), TPM2(1), TTN(121) 10289363 196 24 137 172 64 76 8 34 14 0 1.000 1.000 1.000 109 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CAMK1G(1), ELK1(1), FPR1(8), GNGT1(1), MAP2K1(2), MAP2K3(4), MAP3K1(7), NCF1(1), NCF2(2), NFATC1(6), NFATC2(2), NFATC3(1), NFATC4(1), NFKB1(3), NFKBIA(3), PIK3C2G(10), PLCB1(8), PPP3CA(1), PPP3CC(1), RAC1(1), RAF1(4) 2892818 68 23 55 62 16 15 4 20 13 0 1.000 1.000 1.000 110 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 51 BCL2(1), BIRC2(1), CASP2(1), CASP7(3), CASP8(3), CASP9(4), CHUK(1), DFFA(1), GSN(4), LMNA(3), MAP3K1(7), MAP3K5(1), MAPK8(1), NFKB1(3), NFKBIA(3), NUMA1(2), PAK2(11), PRKCD(1), PSEN1(1), PTK2(2), RASA1(2), RB1(1), SPTAN1(1), TNF(3), TNFRSF1B(3), TRAF1(2) 5125987 66 23 49 96 11 18 5 23 9 0 1.000 1.000 1.000 111 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 65 ADH4(4), ADH7(2), ADHFE1(1), AKR1C1(2), AKR1C2(2), AKR1C3(3), AKR1C4(4), ALDH1A3(3), ALDH3A1(1), ALDH3B2(3), CYP1A1(2), CYP1A2(2), CYP1B1(2), CYP2B6(6), CYP2C18(2), CYP2C19(2), CYP2C8(7), CYP2C9(5), CYP2E1(1), CYP2F1(9), CYP2S1(1), CYP3A4(1), CYP3A43(6), CYP3A5(3), CYP3A7(1), DHDH(8), EPHX1(6), GSTA3(2), GSTA4(1), GSTM5(1), GSTO2(2), GSTP1(1), GSTT2(2), UGT1A1(2), UGT1A10(1), UGT1A3(4), UGT1A4(1), UGT1A6(7), UGT1A7(6), UGT1A9(3), UGT2B15(3), UGT2B17(2), UGT2B28(8), UGT2B4(2), UGT2B7(4) 3903798 141 23 105 113 21 44 4 54 17 1 1.000 1.000 1.000 112 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 33 AKT2(1), BCR(1), BTK(2), CD19(2), CDKN2A(1), GAB1(1), ITPR1(4), ITPR2(3), ITPR3(2), LYN(2), PIK3CA(2), PITX2(1), PLCG2(5), PREX1(8), PTEN(2), PTPRC(1), RPS6KA1(2), RPS6KA2(1), SAG(5), TEC(2), VAV1(3) 4072491 51 23 43 120 13 13 2 13 10 0 1.000 1.000 1.000 113 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 APC(4), AR(6), ASAH1(4), BRAF(3), CCL15(1), EGFR(4), ITPKA(1), ITPKB(10), ITPR1(4), ITPR2(3), ITPR3(2), KCNJ3(1), KCNJ5(1), KCNJ9(2), PIK3CA(2), PIK3CD(1), PITX2(1), PTX3(3), RAF1(4) 3963767 57 23 48 92 12 22 2 14 7 0 1.000 1.000 1.000 114 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 63 ATM(8), CCNA1(1), CCND1(1), CCND2(2), CCND3(3), CCNG2(1), CDKN1A(4), CDKN1B(1), CDKN2A(1), CDKN2B(1), CREB3L1(2), CREB3L4(2), E2F1(2), E2F2(3), E2F3(1), GBA2(1), MCM3(2), MCM4(2), MCM7(2), MYC(7), MYT1(1), NACA(7), POLA2(1), POLE(4), PRIM1(1), RB1(1), TFDP2(1), TNXB(14) 5571334 77 22 64 93 16 27 4 24 6 0 1.000 1.000 1.000 115 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 64 ACHE(1), AGPAT1(1), AGPAT2(1), CDS1(1), CDS2(1), CHAT(4), CHKA(1), CHPT1(2), CRLS1(1), DGKA(1), DGKB(2), DGKD(1), DGKE(1), DGKG(2), DGKH(2), DGKI(5), DGKQ(1), DGKZ(4), ESCO1(1), ETNK2(1), GNPAT(2), GPAM(5), GPD1(1), GPD1L(1), GPD2(3), LCAT(1), LYPLA1(1), LYPLA2(1), PCYT1B(1), PEMT(4), PLA2G2D(1), PLA2G3(4), PLA2G4A(1), PLA2G5(1), PLD1(4), PLD2(13), PNPLA3(5), PPAP2B(1), PTDSS2(2) 4960637 86 22 68 88 17 30 5 27 7 0 1.000 1.000 1.000 116 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPL(2), ALPP(13), ALPPL2(5), ASCC3(5), ATP13A2(1), DDX18(2), DDX23(1), DDX41(2), DDX47(2), DDX51(6), DDX52(4), DDX54(2), DDX55(3), DHX58(5), ENTPD7(3), EP400(7), ERCC2(4), FPGS(2), GCH1(1), GGH(3), IFIH1(7), MOV10L1(17), NUDT5(1), RAD54B(2), SETX(8), SKIV2L2(2), SMARCA2(8), SMARCA5(1) 4657327 119 22 84 115 30 41 7 31 10 0 1.000 1.000 1.000 117 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 56 BMP2(2), BMP4(2), BMP5(1), BMP6(1), BMP7(1), BMP8A(1), BTRC(1), CSNK1A1(2), CSNK1A1L(5), CSNK1E(1), CSNK1G3(1), GLI1(2), GLI2(6), GLI3(3), LRP2(16), PRKACA(1), PRKACG(2), PRKX(1), PTCH1(4), PTCH2(3), RAB23(1), SHH(1), SMO(2), STK36(11), WNT10A(1), WNT16(4), WNT3A(1), WNT5A(1), WNT7B(1), WNT8B(2), WNT9B(2) 4469825 83 22 68 100 25 23 4 25 6 0 1.000 1.000 1.000 118 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 41 BCL2(1), CHUK(1), EGF(4), EGFR(4), ETS1(1), ETS2(2), IKBKB(2), MAP2K1(2), MAP2K3(4), MAP2K4(1), MAP3K1(7), MAP3K5(1), MAPK8(1), NFKB1(3), NFKBIA(3), PPP2CA(1), PRKCD(1), PRKCG(2), PRKCQ(2), RAF1(4), SP1(1), TNF(3), TNFRSF1B(3) 3455633 54 22 48 80 12 21 5 9 7 0 1.000 1.000 1.000 119 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 21 CHUK(1), CREBBP(7), EP300(5), IKBKB(2), MAP2K3(4), MAPK11(1), NFKB1(3), NFKBIA(3), TLR2(2), TNF(3) 2139291 31 22 29 23 6 7 1 8 9 0 0.998 1.000 1.000 120 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(7), AR(6), ESR2(1), NR0B1(2), NR1H2(2), NR2F2(1), PGR(7), PPARA(1), PPARG(3), RARB(1), RARG(1), ROR1(1), THRA(1), THRB(2), VDR(2) 3152858 38 22 29 77 6 9 3 12 8 0 1.000 1.000 1.000 121 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 63 AGTR1(2), AGTR2(3), ATP8A1(2), AVPR1B(3), CCKBR(1), CCR1(1), CCR2(3), CCR3(1), CCR6(1), CCR8(5), CXCR6(1), EDNRA(1), FPR1(8), FSHR(5), GALR1(3), GALR2(1), GALR3(1), GALT(2), GHSR(1), MC1R(4), MC3R(2), MC5R(1), NPY2R(1), NTSR2(1), OPRK1(1), OPRM1(2), OXTR(1), SSTR1(1), SSTR2(1), SSTR3(1), SSTR4(6), TACR2(4), TACR3(1), TSHR(3) 3574002 75 22 62 95 12 26 4 29 4 0 1.000 1.000 1.000 122 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 107 ADCY2(7), ADCY3(2), ADCY4(2), ADCY6(1), ADCY8(1), ADSS(1), AK1(1), AK2(2), AK5(1), AMPD3(3), ATIC(1), ATP5F1(1), DCK(1), ENPP1(3), ENPP3(3), ENTPD2(1), GART(3), GDA(2), GMPS(1), GUCY1A2(2), GUCY1A3(1), GUCY2D(5), NPR1(2), NPR2(1), NT5C(1), NT5E(2), NT5M(1), PAICS(2), PAPSS1(5), PAPSS2(1), PDE4A(3), PDE4C(2), PDE5A(2), PDE6C(1), PDE9A(4), PFAS(6), POLD1(2), POLE(4), POLG(2), POLL(1), POLQ(15), POLR1B(2), POLR2B(1), POLR2E(1), POLRMT(4), PRPS1L1(2), PRUNE(1), RRM1(1) 9216390 114 22 96 192 26 37 6 36 9 0 1.000 1.000 1.000 123 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 92 ANK2(4), CDR1(2), DGKI(5), IL6ST(4), MRPL19(3), PIGK(1), RPL13(1), RPL14(1), RPL3(1), RPL37(1), RPL3L(2), RPL4(1), RPL5(1), RPL6(1), RPLP2(1), RPS14(2), RPS6KA1(2), RPS6KA2(1), RPS6KA6(1), RPS6KB2(5), SLC36A2(1), TBC1D10C(1), UBB(1) 3773565 43 22 39 93 6 18 1 10 8 0 1.000 1.000 1.000 124 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 25 AKT2(1), ITPKA(1), ITPKB(10), ITPR1(4), ITPR2(3), ITPR3(2), NFKB1(3), NFKB2(3), NFKBIA(3), NFKBIB(1), PITX2(1), PLD1(4), PLD2(13) 3326898 49 22 37 75 13 11 3 11 11 0 1.000 1.000 1.000 125 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 58 APC(4), CCND1(1), CCND2(2), CCND3(3), CSNK1E(1), DVL1(1), FZD1(1), FZD10(1), FZD2(1), FZD3(1), FZD5(2), FZD6(3), FZD7(1), LDLR(3), MYC(7), PPP2R5E(1), PRKCD(1), PRKCG(2), PRKCQ(2), PRKD1(3), RAC1(1), RHOA(2), SFRP4(2), TCF7(2), WNT10A(1), WNT16(4), WNT5A(1), WNT7B(1) 4287548 55 22 48 99 14 21 3 11 6 0 1.000 1.000 1.000 126 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 62 BCL2(1), BIRC2(1), CASP1(1), CASP10(2), CASP2(1), CASP4(2), CASP7(3), CASP8(3), CASP9(4), CHUK(1), DFFA(1), GZMB(5), IKBKB(2), IRF1(3), IRF2(1), IRF3(3), IRF5(1), IRF7(2), MAP2K4(1), MAP3K1(7), MYC(7), NFKB1(3), NFKBIA(3), NFKBIB(1), PLEKHG5(2), PRF1(2), TNF(3), TNFRSF10B(4), TNFRSF1B(3), TNFRSF21(1), TP73(1), TRAF1(2), TRAF3(4) 4062277 81 21 67 89 17 26 5 23 10 0 1.000 1.000 1.000 127 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 26 BRCA1(12), CCND1(1), CREBBP(7), EP300(5), GRIP1(1), GTF2A1(1), GTF2E1(1), GTF2F1(3), HDAC2(2), HDAC6(2), MEF2C(1), NCOR2(9), NR0B1(2), NRIP1(3), PELP1(6), TBP(2) 3571992 58 21 48 66 14 18 5 13 8 0 1.000 1.000 1.000 128 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 80 ABL1(3), ATM(8), BUB1(1), BUB1B(1), CCNA1(1), CCNB2(2), CCNB3(1), CCND2(2), CCND3(3), CDAN1(7), CDC14A(1), CDC25C(4), CDC6(5), CDH1(1), CDKN1A(4), CDKN2A(1), CHEK2(2), DTX4(2), E2F1(2), E2F2(3), E2F3(1), EP300(5), ESPL1(12), HDAC2(2), HDAC6(2), HDAC8(1), MAD1L1(3), MAD2L1(1), MCM3(2), MCM4(2), MCM7(2), MPEG1(6), PLK1(1), PTPRA(2), RB1(1), SKP2(1), TBC1D8(3) 8042470 101 21 80 104 27 37 5 20 11 1 1.000 1.000 1.000 129 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(1), AGPAT1(1), AGPAT2(1), CDS1(1), CDS2(1), CHAT(4), CHKA(1), CLC(1), CPT1B(4), DGKA(1), DGKB(2), DGKD(1), DGKE(1), DGKG(2), DGKH(2), DGKQ(1), DGKZ(4), GNPAT(2), GPD1(1), GPD2(3), LCAT(1), LGALS13(1), LYPLA1(1), LYPLA2(1), PCYT1B(1), PEMT(4), PLA2G3(4), PLA2G4A(1), PLA2G5(1), PLCG1(3), PLCG2(5), PPAP2B(1) 3794789 59 21 52 77 15 17 3 21 3 0 1.000 1.000 1.000 130 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ADCY4(2), ADCY6(1), ADCY8(1), CACNA1A(3), CACNA1B(7), GNAS(1), GNAT3(1), GNB3(1), GRM4(1), ITPR3(2), KCNB1(1), PRKACA(1), PRKACG(2), PRKX(1), SCNN1A(3), SCNN1B(3), SCNN1G(2), TAS1R1(3), TAS1R2(10), TAS1R3(1), TAS2R1(3), TAS2R14(2), TAS2R16(3), TAS2R38(2), TAS2R39(1), TAS2R4(5), TAS2R40(1), TAS2R41(2), TAS2R42(6), TAS2R43(4), TAS2R46(3), TAS2R5(3), TAS2R50(3), TAS2R7(2), TAS2R8(1), TAS2R9(2), TRPM5(12) 4332525 102 21 75 100 28 35 0 26 13 0 1.000 1.000 1.000 131 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CD2BP2(1), CLK2(2), COL2A1(3), CPSF1(3), DDX20(9), DHX38(1), DHX9(1), DICER1(1), GIPC1(3), METTL3(1), NXF1(3), PRPF18(1), PRPF4(1), PRPF4B(3), PTBP1(1), PTBP2(1), RBM17(1), RBM5(1), RNGTT(1), SF3A2(1), SF3B1(5), SNRPD2(1), SNRPE(1), SPOP(1), SRPK1(1), SRRM1(2), SUPT5H(1) 7805498 51 21 44 144 9 24 1 7 10 0 1.000 1.000 1.000 132 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 49 AKT2(1), BRD4(2), CBL(1), CDKN2A(1), F2RL2(1), GRB2(1), IGFBP1(2), INPPL1(1), IRS1(2), IRS2(2), IRS4(6), LNPEP(3), PARD3(2), PIK3CA(2), PIK3CD(1), PTEN(2), PTPN1(1), RAF1(4), RPS6KA1(2), RPS6KA2(1), SERPINB6(1), SFN(2), SLC2A4(1), SORBS1(4), SOS1(1), SOS2(1), YWHAE(1) 4329199 49 21 43 77 6 24 2 11 6 0 1.000 1.000 1.000 133 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 42 CD3D(1), CD3G(2), ELK1(1), GRB2(1), MAP2K1(2), MAP2K4(1), MAP3K1(7), MAPK8(1), NFATC1(6), NFATC2(2), NFATC3(1), NFATC4(1), NFKB1(3), NFKBIA(3), PIK3CA(2), PLCG1(3), PPP3CA(1), PPP3CC(1), PTPN7(1), RAC1(1), RAF1(4), RASA1(2), SOS1(1), VAV1(3), ZAP70(1) 3519620 52 21 46 50 10 18 5 11 8 0 1.000 1.000 1.000 134 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 23 APC(4), BTRC(1), CCND1(1), CREBBP(7), CSNK1A1(2), CSNK2A1(4), DVL1(1), FZD1(1), MYC(7), PPP2CA(1) 2234633 29 21 29 34 2 8 2 10 7 0 1.000 1.000 1.000 135 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 ASH1L(2), ASH2L(1), CTCFL(5), DOT1L(2), EHMT1(1), EHMT2(2), EZH2(7), JMJD4(3), KDM6A(1), MEN1(1), NSD1(6), PAXIP1(2), PPP1CA(1), PRDM2(7), PRDM6(3), PRDM7(7), PRMT6(2), PRMT8(1), SETD1A(1), SETD2(3), SETDB2(2), SETMAR(5), SMYD3(3), SUV39H1(1), SUV39H2(1), SUV420H1(1), SUV420H2(1), WHSC1(2), WHSC1L1(1) 8993290 75 20 59 77 15 27 6 25 2 0 1.000 1.000 1.000 136 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 CD3D(1), CD3G(2), CREBBP(7), CSK(3), GNAS(1), GNGT1(1), HLA-DRA(2), HLA-DRB1(46), PRKACG(2), PTPRC(1), ZAP70(1) 1715091 67 20 52 46 9 22 2 27 7 0 1.000 1.000 1.000 137 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 CD3D(1), CD3G(2), CREBBP(7), CSK(3), GNAS(1), GNGT1(1), HLA-DRA(2), HLA-DRB1(46), PRKACG(2), PTPRC(1), ZAP70(1) 1715091 67 20 52 46 9 22 2 27 7 0 1.000 1.000 1.000 138 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 28 DPM2(1), EGFR(4), ELK1(1), GNAS(1), GNGT1(1), GRB2(1), KLK2(1), MAP2K1(2), MKNK1(1), MKNK2(3), MYC(7), NGFR(2), PPP2CA(1), PTPRR(3), RAF1(4), RPS6KA1(2), RPS6KA5(1), SOS1(1) 2359550 37 20 35 53 8 15 3 9 2 0 1.000 1.000 1.000 139 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 CAD(1), CDA(2), CTPS2(1), DCK(1), DHODH(1), DPYD(9), DPYS(1), ENTPD3(3), ENTPD4(2), ENTPD5(2), ENTPD6(4), NT5C(1), NT5C1B(2), NT5C2(1), NT5E(2), NT5M(1), POLA2(1), POLD1(2), POLD3(1), POLD4(1), POLE(4), POLE4(2), POLR1A(3), POLR1B(2), POLR2B(1), POLR2E(1), POLR3A(4), PRIM1(1), RFC5(1), RRM1(1), UMPS(2), UPP1(1), UPP2(4) 6027791 66 20 54 137 20 22 2 21 1 0 1.000 1.000 1.000 140 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 54 ADH4(4), ADH7(2), ADHFE1(1), ALDH1A3(3), ALDH3A1(1), ALDH3B2(3), AOC2(2), AOC3(4), AOX1(4), DBH(7), DCT(1), DDC(3), ECH1(2), ESCO1(1), FAH(1), GOT2(4), HEMK1(1), HGD(1), LCMT1(1), LCMT2(1), METTL2B(3), PNPLA3(5), PRMT2(1), PRMT6(2), PRMT8(1), TAT(2), TH(3), TPO(10), TYRP1(1) 4243444 75 20 60 85 24 26 1 19 5 0 1.000 1.000 1.000 141 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 66 ACAA1(3), ACADL(3), ACADM(1), ACOX1(7), ACOX2(1), ACOX3(1), ACSL3(2), ACSL5(2), ADIPOQ(2), ANGPTL4(4), APOA1(1), APOA5(2), AQP7(3), CD36(1), CPT1B(4), CPT1C(1), CPT2(5), CYP27A1(1), CYP4A22(19), CYP8B1(2), EHHADH(3), FABP1(2), FABP3(1), FABP6(2), FABP7(1), HMGCS2(1), ILK(1), LPL(1), OLR1(2), PCK1(3), PCK2(1), PDPK1(1), PLTP(1), PPARA(1), PPARG(3), SCD(2), SLC27A1(1), SLC27A2(2), SLC27A5(8), SLC27A6(2), SORBS1(4), UCP1(2) 4727761 110 20 83 98 29 33 7 36 5 0 1.000 1.000 1.000 142 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 62 ATM(8), ATR(6), CASP8(3), CASP9(4), CCNB2(2), CCNB3(1), CCND1(1), CCND2(2), CCND3(3), CCNG1(1), CCNG2(1), CD82(1), CDKN1A(4), CDKN2A(1), CHEK2(2), DDB2(1), GTSE1(6), IGFBP3(1), PERP(2), PTEN(2), SERPINB5(2), SERPINE1(1), SESN1(2), SFN(2), THBS1(5), TNFRSF10B(4), TP73(1) 4706514 69 20 53 76 9 32 2 20 5 1 1.000 1.000 1.000 143 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 68 AKT2(1), CASP9(4), KDR(8), MAP2K1(2), MAPK11(1), MAPKAPK2(1), NFAT5(1), NFATC1(6), NFATC2(2), NFATC3(1), NFATC4(1), PIK3CA(2), PIK3CD(1), PIK3CG(3), PIK3R2(1), PIK3R3(1), PLA2G2D(1), PLA2G3(4), PLA2G4A(1), PLA2G5(1), PLCG1(3), PLCG2(5), PPP3CA(1), PPP3CC(1), PRKCG(2), PTGS2(1), PTK2(2), RAC1(1), RAC3(1), RAF1(4), SH2D2A(2), SHC2(1), SPHK1(1), SPHK2(1) 5390444 69 20 60 113 20 21 6 19 3 0 1.000 1.000 1.000 144 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 34 BCL2(1), CBL(1), E2F1(2), GRB2(1), IL2RA(1), IL2RB(2), IRS1(2), JAK1(2), JAK3(2), MYC(7), NMI(1), PIK3CA(2), PTPN6(4), RAF1(4), SOCS1(9), SOCS3(1), SOS1(1) 2671180 43 20 42 72 8 18 1 9 7 0 1.000 1.000 1.000 145 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTN1(3), ACTN2(1), BCAR1(2), BCR(1), CAV1(1), CSK(3), GRB2(1), ITGA1(3), MAP2K1(2), MAPK8(1), PPP1R12B(1), PTK2(2), RAF1(4), SOS1(1), TLN1(6) 3511825 32 20 28 55 5 11 3 8 5 0 1.000 1.000 1.000 146 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 43 AGL(6), AMY2A(1), AMY2B(2), ENPP1(3), ENPP3(3), GAA(1), GANAB(3), GBE1(3), GUSB(1), GYS2(2), HK1(1), HK2(4), HK3(1), MGAM(12), PGM1(4), PGM3(1), PYGB(6), PYGL(4), SI(5), UGT1A1(2), UGT1A10(1), UGT1A3(4), UGT1A4(1), UGT1A6(7), UGT1A7(6), UGT1A9(3), UGT2B15(3), UGT2B4(2), UXS1(1) 4864598 93 20 68 99 13 32 4 36 8 0 1.000 1.000 1.000 147 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 40 BCL2(1), BIRC2(1), CASP2(1), CASP7(3), CASP8(3), CASP9(4), GZMB(5), MAP2K4(1), MAP3K1(7), MCL1(1), MYC(7), NFKB1(3), NFKBIA(3), PARP1(2), PRF1(2), TNF(3), TNFRSF1B(3), TRAF1(2) 2667773 52 19 42 65 9 14 5 18 6 0 1.000 1.000 1.000 148 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 45 BCL2(1), BCL2A1(7), BOK(1), CASP1(1), CASP10(2), CASP2(1), CASP4(2), CASP7(3), CASP8(3), CASP9(4), DFFA(1), IKBKE(4), MCL1(1), NFKB1(3), NFKBIA(3), NGFR(2), NTRK1(3), PTPN13(8), TFG(1), TNF(3), TNFRSF1B(3), TRAF1(2), TRAF3(4), TRAF6(1) 3144823 64 19 52 68 14 23 2 18 7 0 1.000 1.000 1.000 149 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 20 ATM(8), ATR(6), BRCA1(12), BRCA2(7), CHEK2(2), FANCA(20), FANCD2(2), FANCE(2), FANCF(1), FANCG(1), HUS1(1), RAD1(3), RAD17(1), RAD50(1) 3119235 67 19 45 50 14 32 5 13 2 1 1.000 1.000 1.000 150 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 33 BTK(2), CD79A(2), ELK1(1), GRB2(1), LYN(2), MAP2K1(2), MAP3K1(7), MAPK8(1), NFATC1(6), NFATC2(2), NFATC3(1), NFATC4(1), PLCG1(3), PPP3CA(1), PPP3CC(1), RAC1(1), RAF1(4), SOS1(1), VAV1(3) 2756669 42 19 37 52 9 14 4 9 6 0 1.000 1.000 1.000 151 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 16 C1S(4), C3(5), C4A(6), C4B(2), C5(6), C6(3), C7(7), C8A(9), C9(2), MASP1(1), MASP2(4), MBL2(4) 2551455 53 19 42 35 12 21 0 18 2 0 0.994 1.000 1.000 152 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 CASP10(2), CASP7(3), CASP8(3), DFFA(1), FAF1(1), LMNA(3), MAP2K4(1), MAP3K1(7), MAPK8(1), PAK2(11), PTPN13(8), RB1(1), RIPK2(1), SPTAN1(1) 3154006 44 19 32 55 5 13 5 16 5 0 1.000 1.000 1.000 153 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 25 GH1(2), GHR(2), GRB2(1), INSR(2), IRS1(2), JAK2(2), MAP2K1(2), PIK3CA(2), PLCG1(3), PTPN6(4), RAF1(4), RPS6KA1(2), SLC2A4(1), SOCS1(9), SOS1(1) 2443030 39 19 37 53 4 17 3 8 7 0 1.000 1.000 1.000 154 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 30 CHUK(1), IFNA1(2), IKBKB(2), IL1A(2), IL1R1(1), IL6(2), IRAK1(3), IRAK2(5), IRAK3(1), MAP2K3(4), MAP3K1(7), MAPK8(1), NFKB1(3), NFKBIA(3), TGFB2(1), TNF(3), TRAF6(1) 2137046 42 19 38 38 12 12 2 8 8 0 1.000 1.000 1.000 155 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1A(3), ADRA1D(2), ADRA2C(1), ADRB1(1), ADRB2(3), CHRM3(5), DRD2(1), DRD3(1), DRD5(5), HRH1(1), HRH2(1), HTR1B(2), HTR1F(3), HTR2A(2), HTR2C(1), HTR4(1), HTR5A(1), HTR7(1) 1909000 35 19 32 47 5 8 4 17 1 0 1.000 1.000 1.000 156 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 16 CHUK(1), CREBBP(7), EP300(5), IKBKB(2), NFKB1(3), NFKBIA(3), TNF(3), TNFRSF1B(3), TRAF6(1) 1696262 28 19 25 19 4 8 0 8 8 0 0.992 1.000 1.000 157 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 30 ANGPTL2(1), DGKA(1), GCA(1), ITGA9(2), ITPKA(1), ITPKB(10), ITPR1(4), ITPR2(3), ITPR3(2), MAP2K1(2), PIK3C2G(10), PIK3CA(2), PIK3CD(1), RIPK3(4) 3472342 44 19 37 83 13 8 2 14 7 0 1.000 1.000 1.000 158 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(2), DLG4(1), EPHB2(1), F2(1), F2RL2(1), F2RL3(1), MAPK7(1), MAPK8(1), PLD1(4), PLD2(13), PTK2(2), RAF1(4), RASAL1(4), TEC(2), VAV1(3) 2044240 41 19 30 30 8 12 4 9 8 0 0.993 1.000 1.000 159 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 32 AKT2(1), ARHGEF11(4), BCL2(1), DLG4(1), GNA13(2), MAP2K4(1), MAP3K1(7), MAP3K5(1), MAPK8(1), NFKB1(3), NFKB2(3), NFKBIA(3), NFKBIB(1), PLD1(4), PLD2(13), PTK2(2), ROCK2(2) 3420407 50 19 39 48 11 12 6 12 9 0 1.000 1.000 1.000 160 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 27 CASP2(1), CASP8(3), DFFA(1), LMNA(3), MAP2K4(1), MAP3K1(7), MAPK8(1), PAK2(11), RB1(1), SPTAN1(1), TNF(3) 2692723 33 19 24 47 3 8 5 11 6 0 1.000 1.000 1.000 161 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CHUK(1), ELK1(1), IKBKB(2), IRAK1(3), MAP2K3(4), MAP2K4(1), MAP3K1(7), MAPK8(1), NFKB1(3), NFKBIA(3), PPARA(1), TIRAP(5), TLR10(5), TLR2(2), TLR3(2), TLR4(2), TLR6(1), TLR7(1), TRAF6(1) 2696002 46 19 41 42 10 18 3 9 6 0 1.000 1.000 1.000 162 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 29 AKR1C4(4), ARSB(5), ARSE(1), CYP11B1(3), CYP11B2(5), HSD3B1(2), HSD3B2(2), UGT1A1(2), UGT1A10(1), UGT1A3(4), UGT1A4(1), UGT1A6(7), UGT1A7(6), UGT1A9(3), UGT2B15(3), UGT2B4(2) 1875162 51 18 35 58 14 14 3 19 1 0 1.000 1.000 1.000 163 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 28 ACP2(3), ACP5(1), ALPL(2), ALPP(13), ALPPL2(5), CYP1A1(2), CYP1A2(2), CYP2A13(5), CYP2A7(8), CYP2B6(6), CYP2C18(2), CYP2C19(2), CYP2C8(7), CYP2C9(5), CYP2D6(11), CYP2E1(1), CYP2F1(9), CYP2J2(1), CYP3A4(1), CYP3A5(3), CYP3A7(1), CYP4B1(4), PON1(6) 2006935 100 18 73 51 29 28 3 31 9 0 0.936 1.000 1.000 164 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 38 ALDOB(1), ALDOC(1), FBP2(2), FPGT(1), FUK(3), GMPPB(2), HK1(1), HK2(4), HK3(1), HSD3B7(2), MTMR1(3), MTMR2(4), PFKM(1), PHPT1(1), PMM2(1), SORD(5) 2686025 33 18 28 76 9 9 0 13 2 0 1.000 1.000 1.000 165 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 54 ADH4(4), ADH7(2), ADHFE1(1), AGPAT1(1), AGPAT2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), CEL(4), DAK(2), DGAT1(1), DGKA(1), DGKB(2), DGKD(1), DGKE(1), DGKG(2), DGKH(2), DGKI(5), DGKQ(1), DGKZ(4), GLB1(1), GPAM(5), LCT(3), LIPA(3), LIPC(3), LIPF(2), LPL(1), PNLIPRP1(4), PNPLA3(5), PPAP2B(1) 4322113 77 18 63 106 9 28 4 28 8 0 1.000 1.000 1.000 166 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 49 AKR1C3(3), ALOX12(3), ALOX12B(1), ALOX15(2), ALOX15B(6), CBR3(4), CYP2B6(6), CYP2C18(2), CYP2C19(2), CYP2C8(7), CYP2C9(5), CYP2E1(1), CYP2J2(1), CYP4A22(19), CYP4F2(4), CYP4F3(1), EPHX2(6), GGT1(6), GPX5(1), LTA4H(2), PLA2G2D(1), PLA2G3(4), PLA2G4A(1), PLA2G5(1), PTGES2(2), PTGIS(1), PTGS1(3), PTGS2(1), TBXAS1(5) 2841469 101 18 73 69 28 27 10 30 6 0 1.000 1.000 1.000 167 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(2), ACACB(12), ACAT1(2), ACAT2(1), ACOT12(3), ACSS1(2), ACSS2(1), ACYP1(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), DLAT(1), GLO1(2), GRHPR(4), LDHA(1), LDHAL6A(2), LDHAL6B(7), MDH2(5), ME2(2), ME3(2), PC(1), PCK1(3), PCK2(1), PDHA2(2) 3395782 71 18 57 91 21 27 3 17 3 0 1.000 1.000 1.000 168 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 38 ALAD(2), ALAS2(1), BLVRA(1), COX10(3), CP(1), CPOX(1), EPRS(2), GUSB(1), MMAB(5), PPOX(2), UGT1A1(2), UGT1A10(1), UGT1A3(4), UGT1A4(1), UGT1A6(7), UGT1A7(6), UGT1A9(3), UGT2B15(3), UGT2B17(2), UGT2B28(8), UGT2B4(2), UGT2B7(4), UROS(1) 2742147 63 18 45 77 11 16 1 33 2 0 1.000 1.000 1.000 169 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 BCL2(1), CREBBP(7), EP300(5), IL7R(7), JAK1(2), JAK3(2), NMI(1), PIK3CA(2), PTK2B(4) 2069090 31 18 25 38 7 12 0 6 6 0 1.000 1.000 1.000 170 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 28 CSF1(2), CSF2(1), HLA-DRA(2), HLA-DRB1(46), IFNA1(2), IL11(1), IL12B(2), IL1A(2), IL3(3), IL6(2), TGFB2(1), TNF(3) 971495 67 18 49 42 11 26 3 24 3 0 0.988 1.000 1.000 171 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 34 DOCK1(7), ELK1(1), GAB1(1), GRB2(1), ITGA1(3), MAP2K1(2), MAP4K1(1), MAPK8(1), MET(2), PIK3CA(2), PTEN(2), PTK2(2), PTK2B(4), RAF1(4), RASA1(2), SOS1(1) 3225592 36 18 31 72 3 18 2 6 7 0 1.000 1.000 1.000 172 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 24 ATM(8), CCND2(2), CDKN1B(1), EGR1(1), ESR2(1), FSHR(5), GJA4(5), INHA(4), MLH1(5), MSH5(4), NCOR1(5), NRIP1(3), PGR(7), PRLR(2), VDR(2), ZP2(3) 2444207 58 18 45 44 4 35 1 17 1 0 0.998 1.000 1.000 173 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(3), ALOX12(3), ALOX15(2), CBR3(4), CYP4F2(4), CYP4F3(1), EPX(3), GGT1(6), LPO(2), LTA4H(2), PLA2G3(4), PLA2G4A(1), PLA2G5(1), PTGES2(2), PTGIS(1), PTGS1(3), PTGS2(1), TBXAS1(5), TPO(10) 2096266 58 18 46 61 15 16 4 22 1 0 1.000 1.000 1.000 174 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 29 ARHGAP4(2), ARHGAP5(2), ARHGAP6(2), ARHGEF1(1), ARHGEF11(4), ARHGEF5(8), ARPC1B(3), GSN(4), LIMK1(1), MYLK(8), PFN1(3), PIP5K1A(1), PIP5K1B(1), PPP1R12B(1), TLN1(6) 3450227 47 18 36 25 9 12 3 14 9 0 0.906 1.000 1.000 175 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 32 GORASP1(1), MAP2K4(1), MAPK11(1), MAPK8(1), MAPK8IP1(2), MAPK8IP3(2), MAPKAPK5(2), NFKB1(3), NFKB2(3), NFKBIA(3), NFKBIB(1), PIK3CA(2), PIK3CD(1), TRAF3(4), TRAF6(1) 2611810 28 18 25 29 7 10 2 4 5 0 1.000 1.000 1.000 176 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(4), ASAH1(4), CERK(2), CXCL2(1), EPHB2(1), ITPKA(1), ITPKB(10), MAP2K4(1), MAPK8(1), MAPK8IP1(2), MAPK8IP3(2) 2114383 29 18 23 32 5 13 2 6 3 0 1.000 1.000 1.000 177 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 34 ANKHD1(3), EEF1B2(1), EEF2K(3), EIF2AK1(2), EIF2AK2(1), EIF2B3(2), EIF2B4(2), EIF2B5(4), EIF2S2(1), EIF2S3(2), EIF4A2(1), EIF4G1(2), EIF4G3(2), EIF5B(2) 2932344 28 18 26 47 2 7 4 12 3 0 1.000 1.000 1.000 178 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 ARNT(1), EIF2B3(2), EIF2B4(2), EIF2B5(4), EIF2S2(1), EIF2S3(2), ELAVL1(1), FLT1(2), FLT4(5), KDR(8), PIK3CA(2), PLCG1(3), PTK2(2) 2546146 35 18 30 40 5 13 3 14 0 0 1.000 1.000 1.000 179 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGT(4), AGTR1(2), EGFR(4), ELK1(1), GRB2(1), MAP2K1(2), MAP2K4(1), MAP3K1(7), MAPK8(1), MEF2B(3), MEF2C(1), PTK2(2), PTK2B(4), RAC1(1), RAF1(4), SOS1(1) 2511670 39 17 33 58 9 13 3 8 6 0 1.000 1.000 1.000 180 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 18 ABL1(3), ATM(8), BRCA1(12), CDKN1A(4), CHEK2(2), MAPK8(1), NFKB1(3), NFKBIA(3), RAD50(1), TP73(1) 2095257 38 17 30 29 5 19 5 4 4 1 0.996 1.000 1.000 181 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 35 AGT(4), AGTR2(3), CAMK2G(1), F2(1), GNGT1(1), GRB2(1), JAK2(2), MAP2K1(2), MAPK8(1), MYLK(8), PLCG1(3), PTK2B(4), RAF1(4), SOS1(1), STAT1(1) 2881238 37 17 31 68 8 10 6 9 4 0 1.000 1.000 1.000 182 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCL11(1), CCR3(1), GNAS(1), GNGT1(1), LIMK1(1), MAP2K1(2), PIK3C2G(10), PLCB1(8), PPP1R12B(1), PTK2(2), RAF1(4), ROCK2(2) 1878938 34 17 29 28 9 7 1 10 7 0 1.000 1.000 1.000 183 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 MAP2K1(2), MYC(7), NFKB1(3), NFKBIA(3), PLCB1(8), RAF1(4), TNF(3) 1124288 30 17 27 28 2 8 2 8 10 0 1.000 1.000 1.000 184 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 13 C1S(4), C3(5), C4A(6), C4B(2), C5(6), C6(3), C7(7), C8A(9), C9(2) 2264301 44 17 34 32 8 18 0 17 1 0 0.997 1.000 1.000 185 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 15 C1S(4), C3(5), C4A(6), C4B(2), C5(6), C6(3), C7(7), C8A(9), C8B(3), C9(2), MASP1(1) 2500893 48 17 37 32 8 21 0 18 1 0 0.993 1.000 1.000 186 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(2), GSN(4), ITGA1(3), MAP2K1(2), MYLK(8), PFN1(3), PIK3CA(2), PTK2(2), RAF1(4), TLN1(6) 2752225 36 17 31 32 7 10 3 11 5 0 1.000 1.000 1.000 187 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 25 CSNK2A1(4), EGF(4), EGFR(4), ELK1(1), GRB2(1), JAK1(2), MAP2K1(2), MAP2K4(1), MAP3K1(7), MAPK8(1), PIK3CA(2), PLCG1(3), RAF1(4), RASA1(2), SOS1(1), STAT1(1) 2629914 40 17 35 45 4 23 5 4 4 0 1.000 1.000 1.000 188 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOB(1), ALDOC(1), DLAT(1), ENO1(1), ENO3(2), FBP2(2), GOT2(4), HK1(1), HK2(4), HK3(1), LDHA(1), LDHAL6B(7), MDH2(5), PC(1), PCK1(3), PDHA2(2), PDHX(3), PFKM(1), PGAM2(1), PGK2(1) 3067490 43 17 32 82 10 19 2 9 3 0 1.000 1.000 1.000 189 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(2), ACSS2(1), ACYP1(1), ADH4(4), ADH7(2), ADHFE1(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH3B2(3), ALDH7A1(1), ALDH9A1(3), ALDOB(1), ALDOC(1), DLAT(1), ENO1(1), ENO3(2), FBP2(2), G6PC2(6), GALM(2), HK1(1), HK2(4), HK3(1), LDHA(1), LDHAL6A(2), LDHAL6B(7), PDHA2(2), PFKM(1), PGAM2(1), PGAM4(1), PGK2(1), PGM1(4), PGM3(1) 4254169 71 17 54 106 15 26 2 22 6 0 1.000 1.000 1.000 190 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 23 GUSB(1), UGT1A1(2), UGT1A10(1), UGT1A3(4), UGT1A4(1), UGT1A6(7), UGT1A7(6), UGT1A9(3), UGT2B15(3), UGT2B17(2), UGT2B28(8), UGT2B4(2), UGT2B7(4), XYLB(3) 1697223 47 17 33 51 4 12 1 28 2 0 1.000 1.000 1.000 191 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 111 ATP12A(3), ATP4A(1), ATP5F1(1), ATP6V0A1(2), ATP6V0A2(2), ATP6V0A4(1), ATP6V0B(1), ATP6V0D2(1), ATP6V1A(1), ATP6V1B1(2), ATP6V1C2(2), ATP6V1G3(1), ATP6V1H(1), COX10(3), COX4I2(2), COX7B(1), NDUFA2(1), NDUFA9(1), NDUFS1(1), NDUFS2(3), NDUFS4(1), NDUFS7(1), PPA2(4), SDHA(6), SDHC(1), TCIRG1(2), UQCRC1(1), UQCRH(2) 4129190 49 17 40 81 18 11 1 16 3 0 1.000 1.000 1.000 192 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 40 ALG1(6), ALG10(1), ALG11(1), ALG12(1), ALG14(2), ALG3(1), ALG6(4), ALG8(3), ALG9(1), B4GALT2(1), B4GALT3(2), DOLPP1(1), DPAGT1(2), FUT8(4), GANAB(3), MAN1A2(1), MAN1B1(1), MAN1C1(1), MAN2A1(1), MGAT1(6), MGAT4A(2), MGAT5(1), MGAT5B(2), RFT1(1), RPN2(1), ST6GAL1(3), STT3B(1) 3102787 54 17 47 58 12 22 3 14 3 0 1.000 1.000 1.000 193 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 38 ANAPC1(3), ANAPC4(3), BTRC(1), CDC16(3), CUL1(2), FZR1(1), ITCH(1), SKP1(1), SKP2(1), SMURF1(1), SMURF2(1), UBA1(2), UBE2D3(1), UBE2E3(1), WWP2(1) 2914376 23 17 20 48 7 6 0 3 6 1 1.000 1.000 1.000 194 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 44 AKT2(1), BRAF(3), PDPK1(1), PIK3CA(2), PIK3CD(1), PIK3CG(3), PIK3R2(1), PIK3R3(1), PRKAA1(1), RICTOR(4), RPS6KA1(2), RPS6KA2(1), RPS6KA6(1), RPS6KB2(5), STK11(1), TSC1(4), ULK1(3), ULK2(1), ULK3(3), VEGFB(1), VEGFC(2) 4010905 42 17 36 76 11 15 1 8 7 0 1.000 1.000 1.000 195 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(2), ACE2(2), AGT(4), AGTR1(2), AGTR2(3), ANPEP(4), CMA1(1), CTSG(1), ENPEP(2), LNPEP(3), MAS1(1), MME(4), NLN(4), THOP1(1) 1540715 34 17 32 17 8 11 1 10 4 0 0.811 1.000 1.000 196 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 49 ABL1(3), ACTB(5), ARHGEF2(2), CDH1(1), CTTN(1), EZR(1), HCLS1(7), NCK1(2), NCL(4), RHOA(2), ROCK2(2), TLR4(2), TLR5(4), TUBA1B(1), TUBA1C(1), TUBA3C(3), TUBA3E(8), TUBA8(3), TUBAL3(1), TUBB1(4), TUBB2A(1), TUBB6(2), TUBB8(5), WAS(1), WASL(1) 3720120 67 17 53 93 26 16 0 9 16 0 1.000 1.000 1.000 197 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 49 ABL1(3), ACTB(5), ARHGEF2(2), CDH1(1), CTTN(1), EZR(1), HCLS1(7), NCK1(2), NCL(4), RHOA(2), ROCK2(2), TLR4(2), TLR5(4), TUBA1B(1), TUBA1C(1), TUBA3C(3), TUBA3E(8), TUBA8(3), TUBAL3(1), TUBB1(4), TUBB2A(1), TUBB6(2), TUBB8(5), WAS(1), WASL(1) 3720120 67 17 53 93 26 16 0 9 16 0 1.000 1.000 1.000 198 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 20 CSNK2A1(4), ELK1(1), GRB2(1), IL6(2), IL6R(2), IL6ST(4), JAK1(2), JAK2(2), JAK3(2), MAP2K1(2), RAF1(4), SOS1(1) 1661946 27 17 26 27 6 12 1 5 3 0 1.000 1.000 1.000 199 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 15 C3(5), C5(6), C6(3), C7(7), ICAM1(6), IL1A(2), IL6(2), ITGA4(5), ITGAL(1), SELP(6), TNF(3), VCAM1(1) 1741630 47 17 38 54 12 13 0 19 2 1 1.000 1.000 1.000 200 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 20 CHUK(1), IKBKB(2), IL1A(2), IL1R1(1), IRAK1(3), MAP3K1(7), NFKB1(3), NFKBIA(3), TLR4(2), TNF(3), TNFRSF1B(3), TRAF6(1) 1691438 31 17 28 26 7 11 0 7 6 0 0.999 1.000 1.000 201 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 27 CAV1(1), CHRNA1(1), FLT1(2), FLT4(5), KDR(8), PDE2A(1), PRKACG(2), PRKG1(3), PRKG2(1), RYR2(9), SLC7A1(1) 2943726 34 17 28 53 3 13 1 16 1 0 1.000 1.000 1.000 202 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(2), ACAT1(2), ACAT2(1), ACYP1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), DLAT(1), GLO1(2), GRHPR(4), LDHA(1), MDH2(5), ME2(2), ME3(2), PC(1), PCK1(3), PDHA2(2) 2693336 43 17 38 65 8 17 2 14 2 0 1.000 1.000 1.000 203 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 27 AKT2(1), BCL2(1), GRB2(1), IL4R(15), IRS1(2), IRS2(2), JAK1(2), JAK3(2), MAP4K1(1), PIK3CA(2), PIK3CD(1), RAF1(4), SOCS1(9), SOS1(1), SOS2(1), STAT6(4) 2709873 49 17 41 60 8 24 6 6 5 0 1.000 1.000 1.000 204 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 ADRB1(1), APC(4), ASAH1(4), DLG4(1), EPHB2(1), ITPR1(4), ITPR2(3), ITPR3(2), KCNJ3(1), KCNJ5(1), KCNJ9(2), PITX2(1), PTX3(3), RAC1(1), RYR1(4) 3412968 33 17 29 108 8 10 3 10 2 0 1.000 1.000 1.000 205 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 ATF1(1), CASP2(1), CHUK(1), IKBKB(2), MAP2K3(4), MAP2K4(1), MAP3K1(7), MAPK8(1), NFKB1(3), NFKBIA(3), TANK(2), TNF(3) 1811834 29 17 27 23 6 7 3 4 9 0 0.997 1.000 1.000 206 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 14 BCL2(1), EGFR(4), MYC(7), PPP2CA(1), RB1(1), TEP1(24), TERT(1), TNKS(2), XRCC5(2) 1969938 43 17 33 59 11 15 3 12 2 0 1.000 1.000 1.000 207 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 53 ACAT1(2), ACAT2(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), AOC2(2), AOC3(4), AOX1(4), CYP1A1(2), CYP1A2(2), CYP2A13(5), CYP2A7(8), CYP2B6(6), CYP2C18(2), CYP2C19(2), CYP2C8(7), CYP2C9(5), CYP2D6(11), CYP2E1(1), CYP2F1(9), CYP2J2(1), CYP3A4(1), CYP3A5(3), CYP3A7(1), CYP4B1(4), DDC(3), ECHS1(1), EHHADH(3), HAAO(1), KYNU(1), TDO2(1), WARS2(1) 3949468 108 17 88 76 31 36 2 29 10 0 1.000 1.000 1.000 208 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(2), AGT(4), AGTR1(2), AGTR2(3), CMA1(1), COL4A1(3), COL4A2(5), COL4A3(12), COL4A4(11), COL4A5(1) 1880144 44 16 35 38 11 12 1 15 5 0 0.999 1.000 1.000 209 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(4), ELK1(1), EPOR(1), GRB2(1), JAK2(2), MAP2K1(2), MAPK8(1), PLCG1(3), PTPN6(4), RAF1(4), SOS1(1) 1616140 24 16 23 17 2 10 4 4 4 0 0.971 1.000 1.000 210 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 21 ATM(8), ATR(6), BRCA1(12), CDC25C(4), CDKN1A(4), CHEK2(2), EP300(5), MYT1(1), RPS6KA1(2) 3083407 44 16 32 39 8 20 4 11 0 1 1.000 1.000 1.000 211 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 44 ADH4(4), ADH7(2), ADHFE1(1), AGPAT1(1), AGPAT2(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), CEL(4), DGAT1(1), DGKA(1), DGKB(2), DGKD(1), DGKE(1), DGKG(2), DGKH(2), DGKQ(1), DGKZ(4), GLB1(1), LCT(3), LIPC(3), LIPF(2), LPL(1), PNLIPRP1(4), PPAP2B(1) 3556161 57 16 48 90 10 20 4 16 7 0 1.000 1.000 1.000 212 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 19 ADCYAP1R1(4), CALCR(5), CALCRL(2), CD97(2), CRHR1(1), ELTD1(7), EMR2(4), GHRHR(2), GIPR(1), GLP1R(3), GLP2R(3), LPHN1(1), LPHN2(3), LPHN3(1), SCTR(1), VIPR2(1) 1922050 41 16 32 34 8 13 5 14 1 0 0.999 1.000 1.000 213 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 25 APC(4), CCND1(1), DVL1(1), FZD1(1), GJA1(1), IRAK1(3), LBP(8), NFKB1(3), PDPK1(1), PIK3CA(2), PPP2CA(1), TIRAP(5), TLR4(2) 2258359 33 16 26 46 7 13 4 5 4 0 1.000 1.000 1.000 214 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS2(3), ACY3(1), ADSS(1), ADSSL1(3), AGXT(1), AGXT2(4), ASS1(1), CAD(1), DARS2(1), DDO(1), DLAT(1), GAD1(2), GAD2(1), GOT2(4), GPT(1), NARS2(1), PC(1), PDHA2(2) 2795367 30 16 26 49 10 6 2 12 0 0 1.000 1.000 1.000 215 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 46 AASDHPPT(2), AASS(2), ACAT1(2), ACAT2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), DOT1L(2), ECHS1(1), EHHADH(3), EHMT1(1), EHMT2(2), HSD17B4(4), HSD3B7(2), NSD1(6), OGDH(2), OGDHL(3), PIPOX(1), PLOD1(2), PLOD2(2), SETD1A(1), SHMT1(3), SHMT2(1), SPCS1(1), SUV39H1(1), SUV39H2(1) 4219247 60 16 55 79 12 26 2 17 3 0 1.000 1.000 1.000 216 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT2(3), COASY(4), DPYD(9), DPYS(1), ENPP1(3), ENPP3(3), PANK1(1), PANK2(1), PANK4(5), VNN1(9) 1282087 39 16 28 19 4 15 5 13 2 0 0.805 1.000 1.000 217 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 ELK1(1), GRB2(1), MAP2K4(1), MAP3K1(7), MAP3K5(1), MAPKAPK2(1), MAPKAPK5(2), MEF2B(3), MEF2C(1), MKNK1(1), MYC(7), PLA2G4A(1), RAC1(1), RPS6KA5(1), STAT1(1), TGFB2(1) 2755235 31 16 29 53 5 11 2 8 5 0 1.000 1.000 1.000 218 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 COASY(4), DPYD(9), DPYS(1), ENPP1(3), ENPP3(3), PANK1(1), PANK2(1), PANK4(5) 1032407 27 16 20 16 4 9 5 8 1 0 0.916 1.000 1.000 219 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 CAD(1), CDA(2), CTPS2(1), DCK(1), DHODH(1), DPYD(9), DPYS(1), NT5C(1), NT5E(2), NT5M(1), POLD1(2), POLE(4), POLG(2), POLL(1), POLQ(15), POLR1B(2), POLR2B(1), POLR2E(1), POLRMT(4), RRM1(1), UMPS(2), UPP1(1) 4277682 56 16 47 109 10 25 3 17 1 0 1.000 1.000 1.000 220 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 CDK5R1(1), LIMK1(1), MAP3K1(7), MYLK(8), NCF2(2), PIK3CA(2), PLD1(4), PPP1R12B(1), RAC1(1), RALBP1(1), TRIO(3), VAV1(3), WASF1(1) 2554515 35 16 29 32 9 8 4 11 3 0 1.000 1.000 1.000 221 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 BCR(1), ELK1(1), GRB2(1), LYN(2), MAP2K1(2), MAP3K1(7), MAPK8IP3(2), PAPPA(4), RAC1(1), RPS6KA1(2), SOS1(1), VAV1(3), VAV2(3), VAV3(4) 2369020 34 16 29 63 8 13 1 9 3 0 1.000 1.000 1.000 222 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 37 DUSP4(2), DUSP8(1), GAB1(1), IL1R1(1), MAP2K4(1), MAP3K1(7), MAP3K10(1), MAP3K11(1), MAP3K13(1), MAP3K4(1), MAP3K5(1), MAPK7(1), MAPK8(1), NFATC3(1), PAPPA(4), TRAF6(1), ZAK(3) 3638958 29 16 26 54 11 7 2 8 1 0 1.000 1.000 1.000 223 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 31 AKT2(1), ANKRD6(3), APC(4), AXIN2(4), CER1(4), CSNK1A1(2), DACT1(7), DKK2(2), DVL1(1), LRP1(6), MVP(2), NKD2(2), PSEN1(1), PTPRA(2), SENP2(1) 3007405 42 16 33 55 14 18 0 8 2 0 1.000 1.000 1.000 224 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD86(1), HLA-DRA(2), HLA-DRB1(46), IFNGR2(2), IL12B(2), IL12RB1(8), IL12RB2(2), IL18R1(1), IL2RA(1), IL4R(15) 915108 80 16 54 48 10 31 8 27 4 0 0.995 1.000 1.000 225 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 30 ADH4(4), ADH7(2), ADHFE1(1), ALDH1A3(3), ALDH3A1(1), ALDH3B2(3), AOC2(2), AOC3(4), AOX1(4), DBH(7), DCT(1), DDC(3), FAH(1), GOT2(4), HGD(1), TAT(2), TH(3), TPO(10) 2226530 56 16 44 65 21 17 1 13 4 0 1.000 1.000 1.000 226 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ACADL(3), ACADM(1), ACADSB(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), AOC2(2), AOC3(4), CNDP1(8), DPYD(9), DPYS(1), ECHS1(1), EHHADH(3), GAD1(2), GAD2(1) 2109652 51 15 42 40 10 22 1 14 4 0 1.000 1.000 1.000 227 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(1), F11(1), F12(1), F13B(1), F2(1), F5(18), F7(3), F8(3), F9(1), FGA(2), FGB(1), FGG(1), PLAT(1), PLG(4), SERPINB2(4), SERPINE1(1), SERPINF2(8), VWF(11) 2379857 63 15 45 82 19 31 0 11 2 0 1.000 1.000 1.000 228 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 15 ADAM12(1), AGT(4), AGTR2(3), EDNRA(1), EGF(4), EGFR(4), MYC(7), NFKB1(3), PLCG1(3) 1453474 30 15 25 40 5 10 3 10 2 0 1.000 1.000 1.000 229 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 19 ATM(8), BCL2(1), CASP7(3), CASP9(4), PTK2(2), STAT1(1), TLN1(6) 1934847 25 15 18 31 3 13 1 5 3 0 1.000 1.000 1.000 230 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 9 CD3D(1), CD3G(2), GZMB(5), HLA-A(93), ICAM1(6), ITGAL(1), PRF1(2) 609963 110 15 73 62 12 36 5 48 8 1 0.993 1.000 1.000 231 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 22 BCAR1(2), GNGT1(1), MAP2K1(2), NFKB1(3), PIK3C2G(10), PIK3CA(2), PLCG1(3), PTK2(2), PTK2B(4), RAF1(4) 2030655 33 15 27 46 8 9 3 7 6 0 1.000 1.000 1.000 232 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 BCL2(1), BCR(1), GRB2(1), JAK2(2), MAP2K1(2), MAP2K4(1), MAP3K1(7), MAPK8(1), MYC(7), PIK3CA(2), RAF1(4), SOS1(1), STAT1(1) 2025614 31 15 30 46 3 14 4 8 2 0 1.000 1.000 1.000 233 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ADH4(4), ADH7(2), ADHFE1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH3B2(3), ALDH9A1(3), ALDOB(1), ALDOC(1), DLAT(1), ENO1(1), ENO3(2), FBP2(2), HK1(1), HK2(4), HK3(1), LDHA(1), PDHA2(2), PFKM(1), PGM1(4), PGM3(1) 3563180 48 15 41 89 10 21 2 11 4 0 1.000 1.000 1.000 234 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 35 AGXT(1), AGXT2(4), ALAS2(1), AMT(1), AOC2(2), AOC3(4), BHMT(1), CBS(2), CHKA(1), CPT1B(4), CTH(2), DAO(2), DMGDH(4), GAMT(1), GARS(1), PEMT(4), PLCG1(3), PLCG2(5), SARDH(2), SARS(1), SHMT1(3), SHMT2(1) 3042478 50 15 42 74 18 16 3 12 1 0 1.000 1.000 1.000 235 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ADH4(4), ADH7(2), ADHFE1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH3B2(3), ALDH9A1(3), ALDOB(1), ALDOC(1), DLAT(1), ENO1(1), ENO3(2), FBP2(2), HK1(1), HK2(4), HK3(1), LDHA(1), PDHA2(2), PFKM(1), PGM1(4), PGM3(1) 3563180 48 15 41 89 10 21 2 11 4 0 1.000 1.000 1.000 236 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 CABIN1(4), CAMK1G(1), INSR(2), MAPK7(1), MEF2B(3), MEF2C(1), NFATC1(6), NFATC2(2), PIK3CA(2), PPP3CA(1), PPP3CC(1) 2582756 24 15 21 54 7 6 0 8 3 0 1.000 1.000 1.000 237 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOB(1), ALDOC(1), DERA(1), FBP2(2), G6PD(1), H6PD(3), PFKM(1), PGD(1), PGM1(4), PGM3(1), PRPS1L1(2), TKT(1), TKTL2(2) 1789884 21 15 18 51 6 10 1 4 0 0 1.000 1.000 1.000 238 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 45 ACAA1(3), ACADL(3), ACADM(1), ACADS(1), ACADSB(2), ACADVL(1), ACAT1(2), ACAT2(1), ACOX1(7), ACOX3(1), ACSL3(2), ACSL5(2), ADH4(4), ADH7(2), ADHFE1(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), CPT1B(4), CPT1C(1), CPT2(5), CYP4A22(19), ECHS1(1), EHHADH(3), HADHB(1), HSD17B4(4) 3447363 85 15 63 62 16 30 7 26 6 0 1.000 1.000 1.000 239 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 42 AGXT(1), AGXT2(4), ALAS2(1), AMT(1), AOC2(2), AOC3(4), BHMT(1), CBS(2), CHKA(1), CTH(2), DAO(2), DMGDH(4), GAMT(1), GARS(1), HSD3B7(2), PEMT(4), PIPOX(1), SARDH(2), SARS(1), SHMT1(3), SHMT2(1) 3054937 41 15 35 68 17 15 1 8 0 0 1.000 1.000 1.000 240 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 43 ACAA1(3), ACADM(1), ACADS(1), ACAT1(2), ACAT2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), AOX1(4), BCAT2(3), BCKDHA(1), BCKDHB(1), DBT(1), ECHS1(1), EHHADH(3), HADHB(1), HIBCH(2), HMGCS2(1), HSD17B4(4), MCCC1(6), MCCC2(1), MCEE(5), MUT(5), OXCT1(2), OXCT2(2), PCCA(1), PCCB(1) 3164456 67 15 57 51 17 21 3 19 7 0 1.000 1.000 1.000 241 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 33 ALDH4A1(2), ASS1(1), CKM(1), CPS1(5), DAO(2), EPRS(2), GAMT(1), GOT2(4), LAP3(1), NOS1(3), OTC(4), P4HA3(2), PARS2(2), PRODH(4), RARS(2), RARS2(5) 2693606 41 15 32 53 9 16 2 12 2 0 1.000 1.000 1.000 242 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ALDH1A3(3), ALDH3A1(1), ALDH3B2(3), AOC2(2), AOC3(4), DDC(3), EPX(3), ESCO1(1), GOT2(4), LPO(2), PNPLA3(5), TAT(2), TPO(10) 2500214 43 15 37 45 14 13 2 13 1 0 1.000 1.000 1.000 243 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 ACAT1(2), ACAT2(1), AFMID(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), AOC2(2), AOC3(4), AOX1(4), CYP1A1(2), CYP1A2(2), CYP1B1(2), DDC(3), ECHS1(1), EHHADH(3), HAAO(1), HEMK1(1), HSD17B4(4), INMT(9), KYNU(1), LCMT1(1), LCMT2(1), LNX1(1), METTL2B(3), OGDH(2), OGDHL(3), PRMT2(1), PRMT6(2), PRMT8(1), TDO2(1), WARS2(1) 4422017 74 15 65 76 19 29 3 20 3 0 1.000 1.000 1.000 244 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 CBS(2), CTH(2), GGT1(6), HEMK1(1), LCMT1(1), LCMT2(1), MAT2B(1), METTL2B(3), PAPSS1(5), PAPSS2(1), PRMT2(1), PRMT6(2), PRMT8(1), SCLY(3) 1834106 30 15 21 25 7 12 0 8 3 0 0.994 1.000 1.000 245 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 27 AMDHD2(1), CHIA(12), CTBS(4), CYB5R1(1), CYB5R3(1), GFPT1(1), GFPT2(2), HEXB(5), HK1(1), HK2(4), HK3(1), MTMR1(3), MTMR2(4), NPL(1), PGM3(1), PHPT1(1), UAP1(1) 1998017 44 15 34 62 8 22 0 11 3 0 1.000 1.000 1.000 246 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 44 AACS(1), AADAC(2), ACADS(1), ACAT1(2), ACAT2(1), ACSM1(3), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH5A1(3), ALDH7A1(1), ALDH9A1(3), BDH1(1), BDH2(2), DDHD1(1), ECHS1(1), EHHADH(3), GAD1(2), GAD2(1), HMGCS2(1), HSD17B4(4), HSD3B7(2), L2HGDH(1), OXCT1(2), OXCT2(2), PDHA2(2), PLA1A(2) 2978465 54 15 48 62 8 23 3 14 6 0 1.000 1.000 1.000 247 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 56 A4GALT(3), B3GALT5(1), B3GNT1(1), B3GNT3(1), B3GNT4(2), B3GNT5(2), B4GALNT1(3), B4GALT2(1), B4GALT3(2), B4GALT4(1), FUT1(1), FUT2(1), FUT3(6), FUT4(1), FUT5(6), GBGT1(4), PIGB(4), PIGC(3), PIGF(1), PIGG(7), PIGK(1), PIGL(1), PIGM(2), PIGN(3), PIGP(2), PIGQ(4), PIGS(1), PIGZ(3), ST3GAL6(1), ST6GALNAC3(1) 3425036 70 15 55 97 13 29 3 21 4 0 1.000 1.000 1.000 248 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 27 AGA(2), ARSB(5), FUCA1(2), FUCA2(8), GALNS(2), GBA(2), GLB1(1), GUSB(1), HEXB(5), HGSNAT(1), HPSE(2), HPSE2(6), IDS(1), IDUA(5), LCT(3), MAN2B2(10), MANBA(7), NAGLU(3), NEU2(3) 2419323 69 15 45 57 22 24 5 16 2 0 1.000 1.000 1.000 249 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 29 ADCY3(2), CAMK2G(1), CLCA1(2), CLCA2(10), CLCA4(6), CNGA4(3), CNGB1(4), PDE1C(5), PRKACA(1), PRKACG(2), PRKG1(3), PRKG2(1), PRKX(1) 2245279 41 15 33 73 5 20 1 11 4 0 1.000 1.000 1.000 250 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 14 ATN1(2), CASP1(1), CASP7(3), CASP8(3), INSR(2), ITCH(1), MAGI1(3), MAGI2(4), RERE(2), WWP2(1) 1661069 22 15 20 56 1 7 0 11 3 0 1.000 1.000 1.000 251 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 40 ADCY3(2), ADCY9(4), AK1(1), ATP6V0A1(2), ATP6V0A2(2), ATP6V0A4(1), ATP6V0B(1), ATP6V0D2(1), ATP6V1A(1), ATP6V1C2(2), ATP6V1G3(1), ATP6V1H(1), GNAS(1), PDIA4(2), PLCG1(3), PLCG2(5), SEC61A1(1), SEC61A2(1), TRIM23(1) 2671635 33 15 29 54 10 12 4 3 4 0 1.000 1.000 1.000 252 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(3), GRB2(1), IL3(3), IL3RA(4), JAK2(2), MAP2K1(2), PTPN6(4), RAF1(4), SOS1(1) 1314470 24 15 19 18 3 9 1 9 2 0 0.987 1.000 1.000 253 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(3), COL4A2(5), COL4A3(12), COL4A4(11), COL4A5(1), F10(1), F11(1), F12(1), F2(1), F2R(1), F5(18), F8(3), F9(1), FGA(2), FGB(1), FGG(1), KLKB1(4), PROC(2), PROS1(1), SERPINC1(1), SERPING1(1) 3290647 72 15 54 84 18 31 1 19 3 0 1.000 1.000 1.000 254 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 16 ABCC1(3), ABCC2(4), ABCG2(3), BCHE(3), CYP3A4(1), CYP3A5(3), UGT1A1(2), UGT1A10(1), UGT1A3(4), UGT1A4(1), UGT1A6(7), UGT1A7(6), UGT1A9(3) 1577076 41 15 29 37 7 14 1 15 4 0 1.000 1.000 1.000 255 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 CSNK2A1(4), DPM2(1), ELK1(1), GRB2(1), KLK2(1), MAP2K1(2), MAPK8(1), NGFR(2), PIK3CA(2), PLCG1(3), RAF1(4), SOS1(1) 1403096 23 15 22 19 2 10 5 2 4 0 0.989 1.000 1.000 256 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 17 HLA-A(93), MAP2K1(2), PIK3CA(2), PTK2B(4), PTPN6(4), RAC1(1), VAV1(3) 1308615 109 15 75 81 12 35 4 45 12 1 1.000 1.000 1.000 257 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 59 ATP12A(3), ATP6V0A1(2), ATP6V0A4(1), ATP6V0B(1), ATP6V1A(1), ATP6V1B1(2), ATP6V1C2(2), ATP6V1G3(1), ATP6V1H(1), ATP7A(1), ATP7B(1), COX10(3), COX7B(1), NDUFS1(1), NDUFS2(3), PPA2(4), SDHA(6), SHMT1(3), UQCRC1(1), UQCRH(2) 2776267 40 15 32 64 11 11 1 16 1 0 1.000 1.000 1.000 258 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 25 CSNK2A1(4), ELK1(1), GRB2(1), JAK1(2), MAP2K1(2), MAP2K4(1), MAP3K1(7), MAPK8(1), PIK3CA(2), PLCG1(3), RAF1(4), RASA1(2), SOS1(1), STAT1(1) 2452743 32 15 29 43 3 18 5 2 4 0 1.000 1.000 1.000 259 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 12 CREBBP(7), PML(2), RB1(1), SIRT1(2), SP100(5), TNF(3), TNFRSF1B(3) 1338156 23 15 20 21 3 6 2 6 6 0 0.999 1.000 1.000 260 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(2), GRB2(1), MAP2K1(2), MAP2K3(4), MAP2K4(1), MAP3K1(7), MAPK8(1), PLCG1(3), PTK2B(4), RAC1(1), RAF1(4), SOS1(1) 2100377 31 15 27 48 6 11 6 2 6 0 1.000 1.000 1.000 261 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 25 AKT2(1), CISH(1), GRB2(1), IARS(2), IL13RA1(1), IL4R(15), JAK1(2), JAK2(2), JAK3(2), PIK3CA(2), SOS1(1), SOS2(1), STAT6(4), TYK2(3) 2690010 38 15 30 41 6 14 6 11 1 0 1.000 1.000 1.000 262 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 ATF1(1), EEF2K(3), ELK1(1), IL1R1(1), MAP2K3(4), MAP2K4(1), MAP3K10(1), MAP3K4(1), MAP3K5(1), MAPK11(1), MAPKAPK2(1), MAPKAPK5(2), MKNK1(1), MKNK2(3), NFKB1(3), TRAF6(1) 2532189 26 15 25 34 8 5 2 4 7 0 1.000 1.000 1.000 263 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 33 AKT2(1), BTK(2), CDKN2A(1), GRB2(1), IARS(2), IGFBP1(2), PIK3CA(2), PTEN(2), RPS6KA1(2), RPS6KA2(1), SFN(2), SOS1(1), SOS2(1), TEC(2), YWHAE(1) 2627883 23 15 19 45 1 9 2 5 6 0 1.000 1.000 1.000 264 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 26 BIRC2(1), CASP8(3), MAP2K4(1), NFKB1(3), NFKB2(3), NFKBIA(3), NFKBIB(1), RALBP1(1), TNF(3), TNFRSF1B(3) 1932946 22 15 20 26 5 4 1 7 5 0 1.000 1.000 1.000 265 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2G(1), ITPKA(1), ITPKB(10), ITPR1(4), ITPR2(3), ITPR3(2), NFAT5(1), PDE6A(1), PDE6C(1), PDE6H(1), SLC6A13(2), TF(2) 2666040 29 15 26 102 9 9 0 6 5 0 1.000 1.000 1.000 266 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 35 ACAA1(3), ACADL(3), ACADM(1), ACADS(1), ACADSB(2), ACAT1(2), ACAT2(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), AOX1(4), BCKDHA(1), BCKDHB(1), ECHS1(1), EHHADH(3), HADHB(1), MCCC1(6), MCCC2(1), MCEE(5), MUT(5), OXCT1(2), PCCA(1), PCCB(1) 2607118 59 15 50 46 16 19 1 16 7 0 1.000 1.000 1.000 267 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CHUK(1), EGR2(1), MAP3K1(7), MYC(7), NFATC1(6), NFATC2(2), NFKB1(3), NFKBIA(3), PLCG1(3), PPP3CA(1), PPP3CC(1), PRKACG(2), VIPR2(1) 2047935 38 15 32 48 6 11 3 13 5 0 1.000 1.000 1.000 268 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 CHUK(1), IKBKB(2), MAP3K1(7), MAP3K5(1), MAP4K5(3), MAPK8(1), NFKB1(3), NFKBIA(3), TNFSF9(1) 1462264 22 14 20 22 4 7 1 5 5 0 1.000 1.000 1.000 269 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 ACVR1(1), APC(4), BMP10(3), BMP2(2), BMP4(2), BMP5(1), BMP7(1), BMPR1A(3), CHRD(4), DVL1(1), FZD1(1), GATA4(2), MEF2C(1), NKX2-5(1), NPPA(1), TGFB2(1), TGFBR3(2) 2695065 31 14 27 53 9 10 3 9 0 0 1.000 1.000 1.000 270 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(1), ACADS(1), ACAT1(2), ACAT2(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH5A1(3), ALDH9A1(3), ECHS1(1), EHHADH(3), GAD1(2), GAD2(1), L2HGDH(1), OXCT1(2), PDHA2(2) 1892140 34 14 31 41 6 14 2 9 3 0 1.000 1.000 1.000 271 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD3D(1), CD3G(2), CD80(2), CD86(1), CTLA4(1), GRB2(1), HLA-DRA(2), HLA-DRB1(46), PIK3CA(2) 923199 58 14 44 30 5 25 1 23 4 0 0.965 1.000 1.000 272 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 BCL2(1), BIRC2(1), CASP10(2), CASP7(3), CASP8(3), CASP9(4), CHUK(1), DFFA(1), LMNA(3), NFKB1(3), NFKBIA(3), SPTAN1(1), TNFRSF10A(7), TNFRSF10B(4) 2478464 37 14 27 48 6 15 1 9 6 0 1.000 1.000 1.000 273 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 41 CDC6(5), CDT1(2), GMNN(1), MCM10(7), MCM3(2), MCM4(2), MCM7(2), NACA(7), POLA2(1), POLD1(2), POLD3(1), POLD4(1), POLE(4), PRIM1(1), RFC4(2), RFC5(1), RPA4(2), UBB(1) 3641868 44 14 31 84 8 20 1 13 2 0 1.000 1.000 1.000 274 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX12(3), ALOX15(2), ALOX15B(6), GGT1(6), LTA4H(2), PTGIS(1), PTGS1(3), PTGS2(1), TBXAS1(5) 1168123 29 14 23 35 7 5 3 11 3 0 1.000 1.000 1.000 275 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 24 ABL1(3), ATM(8), ATR(6), CCNA1(1), CCND1(1), CDKN1A(4), CDKN1B(1), CDKN2A(1), CDKN2B(1), E2F1(2), RB1(1), SKP2(1), TGFB2(1) 2141217 31 14 26 30 9 11 1 6 4 0 1.000 1.000 1.000 276 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ALDH4A1(2), ALDH5A1(3), CAD(1), CPS1(5), EPRS(2), GAD1(2), GAD2(1), GFPT1(1), GLS(1), GLS2(2), GMPS(1), GOT2(4), GPT(1), NADSYN1(1), QARS(1) 2439238 28 14 21 47 5 7 2 11 3 0 1.000 1.000 1.000 277 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 28 ANPEP(4), G6PD(1), GGT1(6), GPX5(1), GSTA3(2), GSTA4(1), GSTM5(1), GSTO2(2), GSTP1(1), GSTT2(2), IDH1(1), PGD(1) 1302021 23 14 17 28 5 9 2 5 1 1 1.000 1.000 1.000 278 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 36 ACAA1(3), ACAD8(1), ADH4(4), ADH7(2), ADHFE1(1), AKR1C4(4), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), BAAT(4), CEL(4), CYP27A1(1), HADHB(1), HSD3B7(2), LIPA(3), SLC27A5(8), SOAT1(1), SOAT2(3) 2243197 56 14 45 60 12 20 2 17 5 0 1.000 1.000 1.000 279 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ALDH4A1(2), ALDH5A1(3), CAD(1), CPS1(5), EPRS(2), GAD1(2), GAD2(1), GFPT1(1), GFPT2(2), GLS(1), GLS2(2), GMPS(1), GOT2(4), GPT(1), NADSYN1(1), QARS(1) 2892271 30 14 22 57 5 9 2 11 3 0 1.000 1.000 1.000 280 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ACADM(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), AOC2(2), AOC3(4), CNDP1(8), DPYD(9), DPYS(1), ECHS1(1), EHHADH(3), GAD1(2), GAD2(1), HIBCH(2), SRM(1) 1960112 49 14 41 36 9 21 1 14 4 0 0.999 1.000 1.000 281 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOB(1), ALDOC(1), FBP2(2), GOT2(4), GPT(1), MDH2(5), ME3(2), PGK2(1), TKT(1), TKTL2(2) 1482453 20 14 17 30 4 7 1 8 0 0 1.000 1.000 1.000 282 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(5), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), CYP2C19(2), CYP2C9(5), DHRS1(2), DHRS2(2), DHRSX(1), ECHS1(1), EHHADH(3), ESCO1(1), PNPLA3(5), YOD1(1) 2253090 42 14 36 37 13 15 0 13 1 0 1.000 1.000 1.000 283 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS2(3), CARS2(5), DARS2(1), EPRS(2), FARS2(1), FARSA(2), FARSB(1), GARS(1), IARS(2), LARS(4), NARS2(1), PARS2(2), QARS(1), RARS(2), RARS2(5), SARS(1), VARS(3), VARS2(10), WARS2(1), YARS2(2) 3934887 50 14 41 79 9 26 1 10 4 0 1.000 1.000 1.000 284 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(4), ELK1(1), GRB2(1), IL2RA(1), IL2RB(2), JAK1(2), JAK3(2), MAP2K1(2), MAPK8(1), RAF1(4), SOS1(1) 1768450 21 14 20 40 4 9 2 2 4 0 1.000 1.000 1.000 285 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 29 DLAT(1), IDH3A(1), IDH3B(1), MDH2(5), OGDH(2), PC(1), PDHA2(2), PDHX(3), SDHA(6), SDHC(1), SUCLG2(1) 2018568 24 14 19 41 8 9 2 4 1 0 1.000 1.000 1.000 286 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(4), CAPN2(4), EP300(5), HDAC2(2), NFATC1(6), NFATC2(2), PPP3CA(1), PPP3CC(1) 1783310 25 14 20 26 6 5 0 12 2 0 1.000 1.000 1.000 287 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(2), ARHGEF1(1), GNA13(2), GNGT1(1), MYLK(8), PLCB1(8), PPP1R12B(1) 1504290 23 14 19 19 3 4 2 5 9 0 0.993 1.000 1.000 288 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 26 CCR1(1), CCR2(3), CCR3(1), CSF2(1), IFNGR2(2), IL12B(2), IL12RB1(8), IL12RB2(2), IL18R1(1), IL4R(15), TGFB2(1) 1404396 37 14 25 39 7 12 8 9 1 0 1.000 1.000 1.000 289 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ARHGEF1(1), F2(1), F2R(1), F2RL3(1), GNA13(2), GNGT1(1), PIK3CA(2), PLCB1(8), PPP1R12B(1), PTK2B(4) 1892787 22 14 18 35 2 5 0 4 11 0 1.000 1.000 1.000 290 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(7), EP300(5), PELP1(6) 1122315 18 14 14 20 1 5 0 8 4 0 1.000 1.000 1.000 291 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOB(1), ALDOC(1), FBP2(2), G6PD(1), H6PD(3), PFKM(1), PGD(1), PGM1(4), PGM3(1), PRPS1L1(2), TKT(1) 1479934 18 14 15 49 6 9 0 3 0 0 1.000 1.000 1.000 292 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ALDH1A3(3), ALDH3A1(1), ALDH3B2(3), AOC2(2), AOC3(4), DDC(3), EPX(3), GOT2(4), LPO(2), TAT(2), TPO(10) 1626548 37 14 32 39 14 11 2 9 1 0 1.000 1.000 1.000 293 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(4), CREBBP(7), DVL1(1), EP300(5), FZD1(1), PITX2(1), TRRAP(2) 2430669 21 14 20 26 5 6 1 6 3 0 1.000 1.000 1.000 294 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(7), EP300(5), LPL(1), NCOA1(2), NCOA2(1), PPARG(3) 1337157 19 14 17 12 1 7 0 7 4 0 0.984 1.000 1.000 295 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(3), DYRK1B(1), GLI2(6), GLI3(3), PRKACG(2), SHH(1), SMO(2) 1223834 18 14 15 29 6 3 1 6 2 0 1.000 1.000 1.000 296 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(1), F2R(1), F2RL3(1), GNGT1(1), ITGA1(3), MAP2K1(2), PLA2G4A(1), PLCB1(8), PTGS1(3), PTK2(2), RAF1(4), TBXAS1(5) 1779098 32 14 29 45 7 9 1 9 6 0 1.000 1.000 1.000 297 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 17 CBL(1), EGF(4), EGFR(4), GRB2(1), MAP2K1(2), PTPRB(8), RAF1(4), RASA1(2), SOS1(1), SPRY3(1) 1782943 28 14 23 32 3 15 4 5 1 0 1.000 1.000 1.000 298 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(8), APOA1(1), APOA4(4), APOC2(1), CETP(5), DGAT1(1), HMGCR(1), LCAT(1), LDLR(3), LIPC(3), LPL(1), LRP1(6), SOAT1(1) 1991949 36 14 28 46 9 16 2 8 1 0 1.000 1.000 1.000 299 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(4), CDH1(1), CREBBP(7), EP300(5), MAP2K1(2), TGFB2(1) 1878924 20 14 19 15 4 6 1 6 3 0 0.993 1.000 1.000 300 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 17 IFNGR2(2), IKBKB(2), JAK2(2), NFKB1(3), NFKBIA(3), RB1(1), TNF(3), TNFRSF1B(3), USH1C(1) 1349903 20 14 17 27 2 5 0 7 6 0 1.000 1.000 1.000 301 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 16 CHUK(1), IKBKAP(11), IKBKB(2), MAP3K1(7), NFKB1(3), NFKBIA(3), TANK(2), TNFRSF1B(3), TRAF1(2), TRAF3(4) 1559001 38 14 28 28 9 15 0 8 6 0 0.997 1.000 1.000 302 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTN1(3), ACTN2(1), ITGA1(3), ITGB3(3), PTK2(2), RAC1(1), SPTAN1(1), TLN1(6) 2124621 20 14 15 31 5 4 2 6 3 0 1.000 1.000 1.000 303 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 CASP9(4), CHUK(1), GH1(2), GHR(2), NFKB1(3), NFKBIA(3), PDPK1(1), PIK3CA(2), PPP2CA(1) 1081965 19 13 16 20 1 8 1 3 6 0 0.999 1.000 1.000 304 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 AGMAT(5), ALDH1A2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH4A1(2), ALDH9A1(3), AOC2(2), AOC3(4), CKM(1), CPS1(5), DAO(2), GAMT(1), GOT2(4), NOS1(3), OTC(4), P4HA3(2), RARS(2) 3328985 51 13 40 68 16 16 0 17 2 0 1.000 1.000 1.000 305 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 26 ACAA1(3), ADH4(4), ADH7(2), ADHFE1(1), AKR1C4(4), ALDH1A2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), BAAT(4), CEL(4), CYP27A1(1), HADHB(1), SOAT2(3) 1645381 41 13 33 47 8 16 1 11 5 0 1.000 1.000 1.000 306 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 9 CD80(2), CR2(7), FCGR2B(1), HLA-DRA(2), HLA-DRB1(46), ICAM1(6), ITGAL(1), PTPRC(1) 867852 66 13 46 37 6 29 1 28 2 0 0.977 1.000 1.000 307 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOB(1), ALDOC(1), FBP2(2), GOT2(4), GPT(1), MDH2(5), ME2(2), ME3(2), TKT(1) 1330472 19 13 16 29 4 7 1 7 0 0 1.000 1.000 1.000 308 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CREBBP(7), EP300(5), NCOA3(3), PRKACG(2) 1523791 17 13 15 30 1 5 0 7 4 0 1.000 1.000 1.000 309 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 CHUK(1), IKBKAP(11), IKBKB(2), MAP3K1(7), NFKB1(3), NFKBIA(3), TRAF3(4), TRAF6(1) 1281025 32 13 24 23 7 14 0 6 5 0 0.996 1.000 1.000 310 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CCNA1(1), CCND1(1), CCND2(2), CCND3(3), CDKN1A(4), CDKN1B(1), CDKN2A(1), CDKN2B(1), E2F1(2), RB1(1) 1174635 17 13 16 21 4 4 1 4 4 0 1.000 1.000 1.000 311 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 ASAH1(4), GNGT1(1), ITGB3(3), PIK3CA(2), PLCB1(8), PTK2(2), RAC1(1), SMPD2(7), SPHK1(1) 1985882 29 13 20 46 5 7 2 8 7 0 1.000 1.000 1.000 312 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(4), EGFR(4), MAP2K1(2), MAP3K1(7), NCOR2(9), THRA(1), THRB(2) 1301855 29 13 25 26 8 14 1 4 2 0 0.999 1.000 1.000 313 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCL11(1), CCR3(1), CSF2(1), HLA-DRA(2), HLA-DRB1(46), IL3(3) 208541 54 13 38 20 6 23 1 22 2 0 0.447 1.000 1.000 314 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 24 ALDOB(1), ALDOC(1), FBP2(2), FPGT(1), GMPPB(2), HK1(1), HK2(4), HK3(1), PFKM(1), PMM2(1), SORD(5) 1724003 20 13 16 48 4 6 0 9 1 0 1.000 1.000 1.000 315 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 B4GALT2(1), FBP2(2), GAA(1), GALK2(1), GALT(2), GANAB(3), GLB1(1), HK1(1), HK2(4), HK3(1), LALBA(1), LCT(3), MGAM(12), PFKM(1), PGM1(4), PGM3(1) 2384083 39 13 33 69 6 17 1 9 6 0 1.000 1.000 1.000 316 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(2), JUNB(1), MAP2K3(4), NFATC1(6), NFATC2(2), PRKACG(2) 921502 17 13 14 25 5 3 1 7 1 0 1.000 1.000 1.000 317 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ELK1(1), GNAS(1), GNGT1(1), MAP2K1(2), NFATC1(6), NFATC2(2), NFATC3(1), NFATC4(1), PLCG1(3), PPP3CA(1), PPP3CC(1), PRKACG(2), RAF1(4) 2587317 26 13 22 49 6 8 3 8 1 0 1.000 1.000 1.000 318 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 26 ACLY(2), CLYBL(4), IDH1(1), IDH3A(1), IDH3B(1), MDH2(5), OGDH(2), OGDHL(3), PC(1), PCK1(3), PCK2(1), SDHA(6), SDHC(1), SUCLG2(1) 2094585 32 13 25 49 8 12 1 9 2 0 1.000 1.000 1.000 319 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 AGMAT(5), ALDH18A1(2), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), AOC2(2), AOC3(4), ASS1(1), CPS1(5), OTC(4), SRM(1) 2171687 38 13 29 39 9 14 0 13 2 0 1.000 1.000 1.000 320 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 6 CYP1A2(2), CYP2A13(5), CYP2A7(8), NAT1(1), NAT2(7), XDH(6) 510834 29 13 20 23 5 15 2 5 2 0 0.981 1.000 1.000 321 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 34 ANPEP(4), G6PD(1), GGT1(6), GPX5(1), GSTA3(2), GSTA4(1), GSTM5(1), GSTO2(2), GSTP1(1), GSTT2(2), IDH1(1), OPLAH(8) 1626442 30 13 21 31 10 8 3 7 1 1 1.000 1.000 1.000 322 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPLD1(5), PGAP1(2), PIGB(4), PIGC(3), PIGF(1), PIGG(7), PIGK(1), PIGL(1), PIGM(2), PIGN(3), PIGP(2), PIGQ(4), PIGS(1), PIGW(2), PIGZ(3) 1820298 41 13 32 61 4 22 2 12 1 0 1.000 1.000 1.000 323 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 30 ALOX15(2), CYP1A2(2), CYP2C18(2), CYP2C19(2), CYP2C8(7), CYP2C9(5), CYP2E1(1), CYP2J2(1), CYP3A4(1), CYP3A43(6), CYP3A5(3), CYP3A7(1), HSD3B7(2), PLA2G2D(1), PLA2G3(4), PLA2G4A(1), PLA2G5(1) 1744179 42 13 35 37 13 10 1 12 6 0 1.000 1.000 1.000 324 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ACACA(2), ACACB(12), ACADM(1), ACAT1(2), ACAT2(1), ACSS1(2), ACSS2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3), ECHS1(1), EHHADH(3), HIBCH(2), LDHA(1), LDHAL6A(2), LDHAL6B(7), MCEE(5), MUT(5), PCCA(1), PCCB(1), SUCLG2(1) 2888515 64 13 50 62 24 24 1 12 3 0 1.000 1.000 1.000 325 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 21 AOX1(4), BST1(4), ENPP1(3), ENPP3(3), NADSYN1(1), NMNAT1(1), NMNAT2(1), NNT(2), NT5C(1), NT5C1B(2), NT5C2(1), NT5E(2), NT5M(1), NUDT12(2), QPRT(1) 1517162 29 13 22 27 7 15 2 3 2 0 0.999 1.000 1.000 326 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 CSNK2A1(4), ELK1(1), GRB2(1), IRS1(2), MAP2K1(2), MAPK8(1), PIK3CA(2), RAF1(4), RASA1(2), SOS1(1) 1814064 20 13 19 22 2 11 2 1 4 0 1.000 1.000 1.000 327 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCL11(1), CCR3(1), HLA-DRA(2), HLA-DRB1(46), IL5RA(2), IL6(2) 380519 54 13 40 27 7 22 1 22 2 0 0.860 1.000 1.000 328 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 CSNK2A1(4), ELK1(1), GRB2(1), INSR(2), IRS1(2), MAP2K1(2), MAPK8(1), PIK3CA(2), RAF1(4), RASA1(2), SLC2A4(1), SOS1(1) 1871350 23 13 22 34 3 13 2 1 4 0 1.000 1.000 1.000 329 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AASDH(8), AASDHPPT(2), AASS(2), ACAT1(2), ACAT2(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), DOT1L(2), ECHS1(1), EHHADH(3), EHMT1(1), EHMT2(2), PLOD1(2), PLOD2(2), SHMT1(3), SHMT2(1) 2719521 46 13 39 58 11 18 0 14 3 0 1.000 1.000 1.000 330 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(4), ENPP1(3), ENPP3(3), NADSYN1(1), NMNAT1(1), NMNAT2(1), NNT(2), NT5C(1), NT5E(2), NT5M(1), QPRT(1) 1071560 20 13 15 11 3 12 1 3 1 0 0.786 1.000 1.000 331 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 PIK3CA(2), PLCB1(8), PLCG1(3), VAV1(3) 939047 16 13 13 16 1 2 2 4 7 0 0.999 1.000 1.000 332 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 25 ALAD(2), BLVRA(1), CP(1), CPOX(1), EPRS(2), GUSB(1), PPOX(2), UGT1A1(2), UGT1A10(1), UGT1A3(4), UGT1A4(1), UGT1A6(7), UGT1A7(6), UGT1A9(3), UGT2B15(3), UGT2B4(2), UROS(1) 1917940 40 13 28 44 6 12 1 21 0 0 1.000 1.000 1.000 333 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ACACA(2), ACADL(3), ACADM(1), ACADSB(2), ACAT1(2), ACAT2(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), ECHS1(1), EHHADH(3), LDHA(1), MCEE(5), MUT(5), PCCA(1), PCCB(1), SUCLG2(1) 2418125 43 13 36 41 12 17 0 12 2 0 1.000 1.000 1.000 334 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 CREBBP(7), DFFA(1), GZMB(5), HMGB2(1), PRF1(2) 788678 16 13 14 12 4 2 2 5 3 0 0.982 1.000 1.000 335 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 ATF1(1), BRAF(3), DUSP4(2), EEF2K(3), GRB2(1), MAP2K1(2), MKNK1(1), MKNK2(3), MOS(2), NFKB1(3), RPS6KA1(2), RPS6KA2(1), SOS1(1), SOS2(1), TRAF3(4) 2214013 30 13 27 50 6 11 2 6 5 0 1.000 1.000 1.000 336 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3D(1), CD3G(2), HLA-DRA(2), HLA-DRB1(46), PTPRC(1), ZAP70(1) 665273 53 13 39 28 6 21 1 22 3 0 0.932 1.000 1.000 337 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 21 CSNK2A1(4), GRB2(1), JAK2(2), MAP2K1(2), PIK3CA(2), PLCG1(3), RAF1(4), RASA1(2), SOS1(1), STAT1(1) 2079522 22 13 20 27 1 12 3 3 3 0 1.000 1.000 1.000 338 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(3), COL4A2(5), COL4A3(12), COL4A4(11), COL4A5(1), SLC23A1(1), SLC2A3(1) 1889149 34 13 26 50 8 10 1 10 5 0 1.000 1.000 1.000 339 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(5), C5(6), C6(3), C7(7), C8A(9), C9(2) 926345 32 12 25 26 6 11 0 14 1 0 0.999 1.000 1.000 340 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 15 ABL1(3), CDKN2A(1), E2F1(2), MYC(7), PIK3CA(2), POLR1A(3), POLR1B(2), RAC1(1), RB1(1) 1408115 22 12 22 36 6 6 2 6 2 0 1.000 1.000 1.000 341 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BCL2(1), CASP8(3), MAP2K1(2), MAP2K4(1), MAP3K1(7), MAPK8(1), NFKB1(3), RAF1(4) 1497609 22 12 20 29 4 9 3 2 4 0 1.000 1.000 1.000 342 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 38 CLDN5(2), CLOCK(2), EIF4G2(1), ETV6(1), GFRA1(1), GSTP1(1), HERPUD1(2), MYF6(1), NCKAP1(2), PER1(4), PER2(4), PIGF(1), UCP3(1), ZFR(2) 2635257 25 12 21 47 5 10 0 4 5 1 1.000 1.000 1.000 343 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 FHL5(5), FSHR(5), GNAS(1), XPO1(3) 704071 14 12 10 11 5 4 2 3 0 0 0.980 1.000 1.000 344 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 19 IFNA1(2), IL12B(2), IL16(4), IL1A(2), IL3(3), IL6(2), IL9(1), TNF(3) 687217 19 12 15 19 7 8 0 3 1 0 0.997 1.000 1.000 345 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 20 ANPEP(4), CD2(1), CD5(3), CSF2(1), IFNA1(2), IL12B(2), IL3(3), ITGAX(6), TLR2(2), TLR4(2), TLR7(1) 1295386 27 12 19 16 8 11 0 7 1 0 0.856 1.000 1.000 346 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1(2), DDX20(9), E2F1(2), ETS1(1), ETS2(2), HDAC2(2), NCOR2(9), RBL2(3) 2019780 30 12 22 43 7 12 2 7 2 0 1.000 1.000 1.000 347 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 MAP2K1(2), MAP2K3(4), MAP3K1(7), NFKB1(3), PIK3CA(2), RB1(1), SP1(1) 1441506 20 12 18 28 4 7 2 2 5 0 1.000 1.000 1.000 348 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 31 B4GALT2(1), G6PC2(6), GAA(1), GALK2(1), GALT(2), GANC(5), GLB1(1), HK1(1), HK2(4), HK3(1), HSD3B7(2), LALBA(1), LCT(3), MGAM(12), PFKM(1), PGM1(4), PGM3(1) 2785763 47 12 37 78 6 18 3 14 6 0 1.000 1.000 1.000 349 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 23 DHCR7(1), FDFT1(2), GGCX(2), GGPS1(1), HMGCR(1), HSD17B7(4), IDI2(2), LSS(3), MVK(2), NSDHL(1), SQLE(1), TM7SF2(3) 1401552 23 12 19 46 7 8 2 3 3 0 1.000 1.000 1.000 350 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ACY3(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH3B2(3), ALDH7A1(1), ALDH9A1(3), AOC2(2), AOC3(4), CNDP1(8), DDC(3), FTCD(1), HDC(4), HEMK1(1), HNMT(1), LCMT1(1), LCMT2(1), METTL2B(3), PRMT2(1), PRMT6(2), PRMT8(1) 2933698 51 12 42 56 16 19 1 10 5 0 1.000 1.000 1.000 351 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 21 ACP2(3), ACP5(1), ACP6(1), ALPL(2), ALPP(13), ALPPL2(5), CYP3A4(1), CYP3A43(6), CYP3A5(3), CYP3A7(1), DHRS1(2), DHRS2(2), DHRSX(1), PON1(6), PON2(3) 1263350 50 12 37 44 9 13 1 20 7 0 1.000 1.000 1.000 352 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(2), FUCA1(2), FUCA2(8), GLB1(1), HEXB(5), LCT(3), MAN2B2(10), MANBA(7), NEU2(3) 1333347 41 12 24 27 9 21 3 7 1 0 0.971 1.000 1.000 353 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(1), EXT2(1), EXTL1(2), EXTL3(1), HS3ST1(1), HS3ST3B1(1), HS3ST5(1), HS6ST1(3), HS6ST2(1), HS6ST3(2), NDST1(1), NDST3(1) 1549052 16 12 15 44 2 4 1 7 2 0 1.000 1.000 1.000 354 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 34 ARSA(4), ARSE(1), ASAH1(4), CERK(2), DEGS1(1), DEGS2(4), ENPP7(4), GAL3ST1(4), GALC(3), GBA(2), GLB1(1), LCT(3), NEU2(3), PPAP2B(1), SGPP1(1), SMPD2(7), SMPD4(2), SPHK1(1), SPHK2(1), UGT8(1) 2493982 50 12 37 56 8 22 3 13 4 0 1.000 1.000 1.000 355 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT1(2), ACAT2(1), ACOT11(5), ACYP1(1), DHRS1(2), DHRS2(2), DHRSX(1), ECHS1(1), EHHADH(3), ESCO1(1), PNPLA3(5), YOD1(1) 1885055 25 12 21 27 5 10 0 10 0 0 1.000 1.000 1.000 356 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 14 BPNT1(1), CHST11(1), CHST12(4), CHST13(2), PAPSS1(5), PAPSS2(1), SULT1A1(3), SULT1A2(3), SULT2B1(3), SUOX(1) 850793 24 12 20 17 7 5 0 10 2 0 0.993 1.000 1.000 357 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2A1(1), GTF2A1L(2), GTF2E1(1), GTF2F1(3), GTF2I(2), GTF2IRD1(1), STON1(3), TAF1(3), TAF1L(2), TAF2(2), TAF4(1), TAF4B(2), TAF5L(2), TAF6(1), TAF6L(1), TAF7L(5) 2665793 32 12 31 51 4 10 2 11 5 0 1.000 1.000 1.000 358 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 23 POLA2(1), POLD1(2), POLD3(1), POLD4(1), POLE(4), POLE4(2), POLG(2), POLG2(1), POLH(2), POLL(1), POLM(1), POLQ(15), PRIM1(1), REV3L(4), RFC5(1) 2858816 39 12 33 43 7 13 2 15 2 0 1.000 1.000 1.000 359 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 EIF2B5(4), EIF2S2(1), EIF2S3(2), INPPL1(1), PDPK1(1), PIK3CA(2), PPP2CA(1), PTEN(2) 1483847 14 12 13 24 2 5 0 5 2 0 1.000 1.000 1.000 360 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CD3D(1), CD3G(2), ETV5(1), IL12B(2), IL12RB1(8), IL12RB2(2), IL18R1(1), JAK2(2), MAPK8(1), TYK2(3) 1381689 23 12 19 25 5 5 2 8 3 0 1.000 1.000 1.000 361 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 12 IL10RA(4), IL22RA1(2), IL22RA2(2), JAK1(2), JAK2(2), JAK3(2), SOCS3(1), STAT1(1), TYK2(3) 1284880 19 12 18 29 5 3 3 7 1 0 1.000 1.000 1.000 362 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 GRB2(1), IL4R(15), IRS1(2), JAK1(2), JAK3(2), STAT6(4) 1084453 26 12 19 26 5 9 6 4 2 0 1.000 1.000 1.000 363 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 CAPN2(4), EGF(4), EGFR(4), ITGA1(3), MYLK(8), PRKACG(2), PTK2(2), TLN1(6) 2464145 33 12 24 50 7 9 2 12 3 0 1.000 1.000 1.000 364 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 17 ABCB1(6), ATM(8), CDKN1A(4), CPB2(2), CSNK1A1(2), IGFBP3(1), MAPK8(1), NFKBIB(1) 1490935 25 12 20 21 3 13 1 6 2 0 0.994 1.000 1.000 365 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 15 ATM(8), BCL2(1), CCND1(1), CDKN1A(4), E2F1(2), RB1(1) 1261450 17 12 14 22 3 8 0 3 3 0 1.000 1.000 1.000 366 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 17 GUSB(1), UGT1A1(2), UGT1A10(1), UGT1A3(4), UGT1A4(1), UGT1A6(7), UGT1A7(6), UGT1A9(3), UGT2B15(3), UGT2B4(2) 1216630 30 12 19 33 3 8 1 18 0 0 1.000 1.000 1.000 367 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 CCND1(1), CDKN1A(4), CDKN1B(1), E2F1(2), NFKB1(3), NFKBIA(3), PIK3CA(2), RAC1(1), RAF1(4), RB1(1) 1489831 22 12 20 25 4 7 0 5 6 0 1.000 1.000 1.000 368 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 AKT2(1), BPNT1(1), GRB2(1), ILK(1), PIK3CA(2), PIK3CD(1), PTEN(2), PTK2B(4), RBL2(3), SOS1(1) 1478442 17 12 14 37 3 4 0 5 5 0 1.000 1.000 1.000 369 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 CBS(2), CTH(2), GGT1(6), MAT2B(1), PAPSS1(5), PAPSS2(1), SCLY(3) 916094 20 12 13 15 5 5 0 8 2 0 0.976 1.000 1.000 370 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 14 C9orf47(1), CNR2(4), DNMT1(2), MTNR1A(2), MTNR1B(2), PTAFR(2), PTGFR(1), PTGIR(2) 848418 16 12 14 36 2 9 1 4 0 0 1.000 1.000 1.000 371 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 ASAH1(4), BFAR(4), BRAF(3), RAF1(4), SNX13(1), TERF2IP(1) 848206 17 12 13 11 0 11 1 4 1 0 0.915 1.000 1.000 372 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 9 AKAP9(8), MAP2(2), PPP1CA(1), PPP2CA(1), PRKACG(2) 1224276 14 11 10 21 0 7 0 7 0 0 1.000 1.000 1.000 373 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD80(2), HLA-DRA(2), HLA-DRB1(46) 284773 50 11 36 27 5 21 1 21 2 0 0.937 1.000 1.000 374 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 HLA-DRA(2), HLA-DRB1(46) 169872 48 11 34 22 5 19 1 21 2 0 0.766 1.000 1.000 375 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 ACHE(1), CHAT(4), DBH(7), DDC(3), GAD1(2), GAD2(1), HDC(4), PAH(1), TH(3) 1060398 26 11 18 33 14 5 1 6 0 0 1.000 1.000 1.000 376 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(4), CYP11B1(3), CYP11B2(5), HSD3B1(2), HSD3B2(2) 662195 16 11 13 25 6 5 3 1 1 0 1.000 1.000 1.000 377 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 BIRC2(1), CASP1(1), CASP10(2), CASP2(1), CASP4(2), CASP7(3), CASP8(3), CASP9(4), DFFA(1), GZMB(5), LMNA(3), PRF1(2) 1424390 28 11 22 36 7 5 3 9 4 0 1.000 1.000 1.000 378 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 19 IDH1(1), IDH3A(1), IDH3B(1), MDH2(5), PC(1), PCK1(3), SDHA(6), SUCLG2(1) 1430973 19 11 14 38 5 9 1 3 1 0 1.000 1.000 1.000 379 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CDK5R1(1), DRD2(1), GRM1(2), PLCB1(8), PPP1CA(1), PPP2CA(1), PPP3CA(1), PRKACG(2) 1180726 17 11 14 29 0 2 0 7 8 0 1.000 1.000 1.000 380 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CSF2(1), FLT3(1), IL11(1), IL1A(2), IL3(3), IL6(2), IL9(1), KITLG(1), TGFB2(1) 631490 13 11 11 12 5 5 0 3 0 0 0.970 1.000 1.000 381 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(1), F2(1), F2R(1), F5(18), F7(3), FGA(2), FGB(1), FGG(1), PROC(2), PROS1(1), SERPINC1(1) 1207552 32 11 23 39 8 20 0 4 0 0 1.000 1.000 1.000 382 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(2), F13A1(8), F2(1), F2R(1), FGA(2), FGB(1), FGG(1), PLAT(1), PLG(4), SERPINB2(4), SERPINE1(1) 974522 26 11 18 31 4 13 0 9 0 0 1.000 1.000 1.000 383 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(2), ACACB(12), FASN(3), MCAT(1) 1217851 18 11 15 23 11 4 1 2 0 0 1.000 1.000 1.000 384 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(4), CYP11B1(3), CYP11B2(5), HSD3B1(2), HSD3B2(2) 662195 16 11 13 25 6 5 3 1 1 0 1.000 1.000 1.000 385 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT2(3), IARS(2), LARS(4), PDHA2(2), VARS(3), VARS2(10) 1352774 24 11 17 40 5 14 1 3 1 0 1.000 1.000 1.000 386 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 13 DHRS1(2), DHRS2(2), DHRSX(1), HSD3B7(2), PON1(6), PON2(3) 606368 16 11 13 20 2 5 0 9 0 0 1.000 1.000 1.000 387 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 29 B3GNT6(1), B4GALT5(1), C1GALT1C1(1), GALNT1(1), GALNT10(1), GALNT12(1), GALNT2(2), GALNT4(5), GALNT5(1), GALNT6(1), GALNT8(8), GALNT9(1), GCNT1(4), GCNT4(2), ST6GALNAC1(3), WBSCR17(1) 2305853 34 11 26 43 4 17 1 12 0 0 1.000 1.000 1.000 388 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(5), GALNS(2), GLB1(1), GUSB(1), HEXB(5), HGSNAT(1), HPSE(2), HPSE2(6), IDS(1), IDUA(5), LCT(3), NAGLU(3) 1543835 35 11 24 43 13 11 2 9 0 0 1.000 1.000 1.000 389 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 15 B3GNT1(1), B3GNT7(2), B4GALT2(1), B4GALT3(2), B4GALT4(1), CHST2(1), CHST4(2), CHST6(1), FUT8(4) 841467 15 11 13 15 5 3 0 6 1 0 0.998 1.000 1.000 390 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT1(1), AGPAT2(1), CHPT1(2), ENPP2(3), PLA2G2D(1), PLA2G3(4), PLA2G4A(1), PLA2G5(1), PLD1(4), PLD2(13), PPAP2B(1) 1736404 32 11 22 36 8 8 4 7 5 0 1.000 1.000 1.000 391 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 20 B3GNT1(1), B3GNT3(1), B3GNT4(2), B3GNT5(2), B4GALT2(1), B4GALT3(2), B4GALT4(1), FUT1(1), FUT2(1), FUT3(6), FUT4(1), FUT5(6), ST3GAL6(1) 1123499 26 11 21 22 10 5 1 9 1 0 0.997 1.000 1.000 392 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(6), AMT(1), ATIC(1), FTCD(1), GART(3), MTHFD1(4), MTHFR(4), MTR(4), SHMT1(3), SHMT2(1) 1405984 28 11 20 22 5 17 1 5 0 0 0.989 1.000 1.000 393 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 EPX(3), LPO(2), MTHFR(4), SHMT1(3), SHMT2(1), TPO(10) 846904 23 11 18 24 6 8 2 7 0 0 1.000 1.000 1.000 394 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 13 ACP2(3), ACP5(1), ACP6(1), ENPP1(3), ENPP3(3), FLAD1(1), MTMR1(3), MTMR2(4), PHPT1(1) 944968 20 11 15 24 5 4 2 8 1 0 1.000 1.000 1.000 395 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACAA1(3), ACOX1(7), ACOX3(1), ELOVL6(1), FASN(3), HSD17B12(2), PECR(4), SCD(2) 1132589 23 11 17 18 7 6 0 10 0 0 0.985 1.000 1.000 396 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 EPX(3), LPO(2), SHMT1(3), SHMT2(1), TPO(10) 872150 19 11 15 19 6 6 2 5 0 0 0.999 1.000 1.000 397 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 12 AGA(2), FUCA1(2), FUCA2(8), GLB1(1), HEXB(5), LCT(3), MANBA(7), NEU2(3) 1185795 31 11 17 25 6 16 3 5 1 0 0.994 1.000 1.000 398 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 DLG4(1), GRIN2A(2), GRIN2B(2), GRIN2C(3), GRIN2D(1), NOS1(3), PPP3CA(1), PPP3CC(1), PRKACG(2) 1912188 16 11 13 55 5 5 0 5 1 0 1.000 1.000 1.000 399 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 13 GALNT1(1), GALNT10(1), GALNT2(2), GALNT4(5), GALNT6(1), GALNT8(8), GALNT9(1), GCNT1(4), WBSCR17(1) 1026964 24 11 18 30 2 12 1 9 0 0 1.000 1.000 1.000 400 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(6), AMT(1), ATIC(1), GART(3), MTHFD1(4), MTHFR(4), MTR(4), SHMT1(3), SHMT2(1) 1303963 27 11 19 19 4 17 1 5 0 0 0.970 1.000 1.000 401 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 NFKB1(3), NFKBIA(3), PLCB1(8) 608492 14 11 11 14 1 1 0 3 9 0 0.999 1.000 1.000 402 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 6 ATM(8), ATR(6), CDC25C(4), CHEK2(2) 1080189 20 11 15 10 6 9 0 4 0 1 0.896 1.000 1.000 403 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 GTF2A1(1), GTF2E1(1), GTF2F1(3), NCOA1(2), NCOA2(1), NCOA3(3), NCOR2(9), TBP(2) 1867153 22 11 21 34 6 8 1 3 4 0 1.000 1.000 1.000 404 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 37 GTF2E1(1), ILK(1), POLR1A(3), POLR1B(2), POLR2B(1), POLR2E(1), POLR3E(1), TAF6(1), TBP(2) 2586925 13 11 13 54 4 3 0 4 2 0 1.000 1.000 1.000 405 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 BIRC2(1), CASP10(2), CASP7(3), CASP8(3), CASP9(4), DFFA(1), GZMB(5), PRF1(2), SCAP(3), SREBF1(1), SREBF2(5) 1391676 30 11 22 21 9 6 3 11 1 0 0.987 1.000 1.000 406 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR2(1), ITPKA(1), PDE1B(1), PLCB1(8), TRH(2) 818032 13 11 10 21 0 3 0 4 6 0 1.000 1.000 1.000 407 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), IL4R(15), JAK1(2), JAK2(2), TYK2(3) 764587 23 11 16 26 3 6 6 8 0 0 1.000 1.000 1.000 408 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), IL4R(15), JAK1(2), JAK2(2), TYK2(3) 764587 23 11 16 26 3 6 6 8 0 0 1.000 1.000 1.000 409 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ARPC1B(3), NCK1(2), NCKAP1(2), NTRK1(3), RAC1(1), WASF1(1), WASF3(3), WASL(1) 1125112 16 10 14 19 6 4 1 5 0 0 0.999 1.000 1.000 410 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 ADSS(1), AGXT(1), AGXT2(4), CAD(1), DDO(1), GAD1(2), GAD2(1), GOT2(4), GPT(1), PC(1) 1913999 17 10 14 35 5 2 1 9 0 0 1.000 1.000 1.000 411 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CYB5R3(1), GFPT1(1), HEXB(5), HK1(1), HK2(4), HK3(1), PGM3(1), UAP1(1) 1258083 15 10 11 31 2 8 0 4 1 0 1.000 1.000 1.000 412 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A1(2), ATP6V0A4(1), ATP6V0B(1), ATP6V1A(1), ATP6V1B1(2), ATP6V1C2(2), ATP6V1G3(1), ATP6V1H(1), SHMT1(3) 1106699 14 10 12 15 3 9 1 1 0 0 0.991 1.000 1.000 413 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 BCL2(1), CSF2RB(3), IL3(3), IL3RA(4), KITLG(1), PIK3CA(2), PRKACG(2) 1610040 16 10 10 40 2 4 0 10 0 0 1.000 1.000 1.000 414 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 17 CDKN1A(4), NFATC1(6), NFATC2(2), NFATC3(1), NFATC4(1), PLCG1(3), PPP3CA(1), PPP3CC(1), SP1(1), SP3(2) 1502460 22 10 18 24 4 7 2 8 1 0 1.000 1.000 1.000 415 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(1), EGF(4), EGFR(4), GRB2(1), MET(2), SH3GLB2(2) 1409572 14 10 12 39 1 9 0 2 2 0 1.000 1.000 1.000 416 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(3), ACTN2(1), BCAR1(2), CSK(3), CTNNA2(3), PTK2(2) 1433513 14 10 12 24 4 2 1 6 1 0 1.000 1.000 1.000 417 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 CAMK2G(1), GNAS(1), GRB2(1), PIK3CA(2), PRKACG(2), RAC1(1), RPS6KA1(2), RPS6KA5(1), SOS1(1) 2173768 12 10 10 51 2 4 0 5 1 0 1.000 1.000 1.000 418 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 GGT1(6), SHMT1(3), SHMT2(1) 319924 10 10 6 5 3 3 0 4 0 0 0.789 1.000 1.000 419 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 GRB2(1), MAPK7(1), MEF2B(3), MEF2C(1), NTRK1(3), PIK3CA(2), PLCG1(3), RPS6KA1(2) 1459328 16 10 13 33 2 4 2 6 2 0 1.000 1.000 1.000 420 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A1(2), ATP6V0A4(1), ATP6V0B(1), ATP6V1A(1), ATP6V1B1(2), ATP6V1C2(2), ATP6V1G3(1), ATP6V1H(1), SHMT1(3) 1106699 14 10 12 15 3 9 1 1 0 0 0.991 1.000 1.000 421 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 21 ARSA(4), ARSB(5), ARSE(1), ASAH1(4), GAL3ST1(4), GALC(3), GBA(2), GLB1(1), LCT(3), NEU2(3), PPAP2B(1), SMPD2(7) 1643521 38 10 25 36 6 17 2 10 3 0 1.000 1.000 1.000 422 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 11 GRHPR(4), HAO1(1), HYI(1), MDH2(5), MTHFD1(4) 853135 15 10 11 20 3 6 1 5 0 0 1.000 1.000 1.000 423 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ALDH1A2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH3B2(3), ALDH9A1(3), AOC2(2), AOC3(4), CNDP1(8), DDC(3), HDC(4), HNMT(1) 1797143 39 10 32 37 13 12 1 9 4 0 1.000 1.000 1.000 424 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 16 CARS2(5), CTH(2), GOT2(4), LDHA(1), LDHAL6A(2), LDHAL6B(7), SULT1C2(2), SULT4A1(1) 877846 24 10 18 23 4 8 0 9 3 0 1.000 1.000 1.000 425 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(4), GAD1(2), GAD2(1), GGT1(6) 428172 13 10 9 9 4 2 0 7 0 0 0.943 1.000 1.000 426 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(1), ADH4(4), ADH7(2), ADHFE1(1), DHRS1(2), DHRS2(2), DHRSX(1), ESCO1(1), PNPLA3(5) 1804083 19 10 14 27 1 6 1 9 2 0 1.000 1.000 1.000 427 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 DHRS1(2), DHRS2(2), DHRSX(1), HEMK1(1), LCMT1(1), LCMT2(1), METTL2B(3), PRMT2(1), PRMT6(2), PRMT8(1) 1089110 15 10 12 18 3 9 0 2 1 0 0.998 1.000 1.000 428 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 AFMID(1), GRHPR(4), HAO1(1), HYI(1), MDH2(5), MTHFD1(4) 898705 16 10 12 22 4 6 1 5 0 0 1.000 1.000 1.000 429 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(3), APOBEC1(3), APOBEC2(2), APOBEC3B(3), APOBEC3C(1), APOBEC3F(3), APOBEC3G(1), APOBEC4(8) 527269 24 10 18 29 2 18 0 3 1 0 1.000 1.000 1.000 430 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 AMT(1), CA13(1), CA3(2), CA5A(1), CA6(5), CA9(5), CPS1(5), CTH(2), GLS(1), GLS2(2) 1540055 25 10 16 29 3 7 3 9 3 0 1.000 1.000 1.000 431 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(3), GBA(2), LPO(2), TPO(10) 618695 17 10 14 15 5 3 3 5 1 0 0.996 1.000 1.000 432 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 28 ATG12(1), ATG3(1), ATG7(1), IFNA1(2), IFNA10(4), IFNA13(1), IFNA14(2), IFNA16(4), IFNA17(1), IFNA5(1), PIK3C3(1), PIK3R4(1), PRKAA1(1), ULK1(3), ULK2(1), ULK3(3) 1547037 28 10 26 20 5 9 1 9 4 0 0.978 1.000 1.000 433 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 10 CLOCK(2), CSNK1E(1), NPAS2(4), PER1(4), PER2(4) 1090038 15 10 13 19 4 5 0 5 1 0 1.000 1.000 1.000 434 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 14 BCL2(1), CASP9(4), IL1A(2), MAPKAPK2(1), TNF(3) 766358 11 10 9 25 2 5 1 2 1 0 1.000 1.000 1.000 435 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNA1(2), IFNAR1(4), IFNAR2(3), JAK1(2), STAT1(1), STAT2(3), TYK2(3) 795943 18 10 15 19 4 4 1 8 1 0 0.999 1.000 1.000 436 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(3), ICAM1(6), ITGA4(5), ITGAL(1), SELE(3), SELL(3) 892169 21 10 16 30 4 10 0 6 0 1 1.000 1.000 1.000 437 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(3), ACADM(1), ACADS(1), ACADVL(1), ACSL3(2), CPT2(5), EHHADH(3), PECR(4) 1226141 20 10 15 17 2 12 0 4 2 0 0.993 1.000 1.000 438 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(3), ICAM1(6), ITGA4(5), ITGAL(1), ITGAM(6), SELE(3), SELL(3), SELP(6) 1185802 33 10 25 39 7 17 0 8 0 1 1.000 1.000 1.000 439 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(6), ABCB11(2), ABCC1(3), ABCC3(5), GSTP1(1) 1054274 17 10 15 36 5 8 1 1 2 0 1.000 1.000 1.000 440 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 EIF4A2(1), EIF4G1(2), EIF4G2(1), EIF4G3(2), MKNK1(1), PDPK1(1), PIK3CA(2), PPP2CA(1), PTEN(2), TSC1(4) 2061261 17 10 17 34 3 4 1 6 3 0 1.000 1.000 1.000 441 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(1), B4GALT2(1), B4GALT3(2), B4GALT5(1), DPAGT1(2), FUT8(4), MAN1B1(1), MGAT1(6), MGAT4A(2), MGAT5(1), RPN2(1), ST6GAL1(3) 1490312 25 10 21 20 6 8 3 8 0 0 0.993 1.000 1.000 442 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(1), CA3(2), CA5A(1), CA6(5), CA9(5), CPS1(5), CTH(2), GLS(1), GLS2(2) 1378211 24 10 15 28 3 6 3 9 3 0 1.000 1.000 1.000 443 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CD2(1), CD3D(1), CD3G(2), IL12B(2), IL12RB1(8), IL12RB2(2), JAK2(2), TYK2(3) 1100637 21 10 17 24 5 4 1 9 2 0 1.000 1.000 1.000 444 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6V0A1(2), ATP6V0A4(1), ATP6V0B(1), ATP6V1A(1), ATP6V1B1(2), ATP6V1C2(2), ATP6V1G3(1), ATP6V1H(1), FDXR(2), SHMT1(3) 1175640 16 10 13 16 5 9 1 1 0 0 0.989 1.000 1.000 445 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 21 BTK(2), EEA1(4), LYN(2), PDPK1(1), PFKM(1), PLCG1(3), RAC1(1), VAV2(3) 1820945 17 10 14 42 4 5 2 4 2 0 1.000 1.000 1.000 446 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 CASP9(4), CHUK(1), ELK1(1), MAP2K1(2), NFKB1(3), PIK3CA(2), RAC1(1), RAF1(4), RALBP1(1), RALGDS(1), RHOA(2) 1448425 22 10 19 27 5 12 2 1 2 0 1.000 1.000 1.000 447 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 CDK5R1(1), DAB1(2), LRP8(3), RELN(9), VLDLR(2) 1008604 17 10 16 11 2 3 1 8 3 0 0.961 1.000 1.000 448 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 10 CISH(1), IL6(2), IL6R(2), JAK1(2), JAK2(2), JAK3(2), PTPRU(4) 1022685 15 10 13 16 5 4 0 6 0 0 0.998 1.000 1.000 449 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(4), JAK1(2), PTPRU(4), STAT1(1), STAT2(3), TYK2(3) 918688 17 10 14 20 4 4 1 7 1 0 1.000 1.000 1.000 450 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 9 EPX(3), LPO(2), TPO(10) 639444 15 10 12 15 5 3 2 5 0 0 0.998 1.000 1.000 451 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A1(2), ATP6V0A4(1), ATP6V0B(1), ATP6V1A(1), ATP6V1B1(2), ATP6V1C2(2), ATP6V1G3(1), ATP6V1H(1), SHMT1(3) 1106699 14 10 12 15 3 9 1 1 0 0 0.991 1.000 1.000 452 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 CDK5R1(1), DPM2(1), EGR1(1), KLK2(1), MAP2K1(2), NGFR(2), RAF1(4) 621918 12 9 12 19 2 4 2 2 2 0 1.000 1.000 1.000 453 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 ARHGAP5(2), CASP1(1), CASP10(2), CASP8(3), CASP9(4), GZMB(5), PRF1(2) 925166 19 9 15 22 5 5 3 3 3 0 1.000 1.000 1.000 454 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(4), EGF(4), EGFR(4), HGS(1), TF(2), TFRC(2) 929705 17 9 14 30 3 9 0 5 0 0 1.000 1.000 1.000 455 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 21 EIF4A2(1), EIF4G1(2), EIF4G2(1), EIF4G3(2), GHR(2), IRS1(2), MKNK1(1), PDPK1(1), PIK3CA(2), PTEN(2) 1983237 16 9 16 33 2 2 1 7 4 0 1.000 1.000 1.000 456 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 EPHB1(3), ITGA1(3), L1CAM(1), LYN(2), SELP(6) 1140399 15 9 13 25 4 6 2 3 0 0 1.000 1.000 1.000 457 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 8 HK1(1), LCT(3), PGM1(4), PYGL(4) 962386 12 9 9 25 1 8 0 1 2 0 1.000 1.000 1.000 458 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(1), FARSA(2), FARSB(1), GOT2(4), PAH(1), TAT(2), YARS2(2) 632714 13 9 11 18 2 3 1 6 1 0 1.000 1.000 1.000 459 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CHPT1(2), HEMK1(1), LCMT1(1), LCMT2(1), METTL2B(3), PCYT1B(1), PRMT2(1), PRMT6(2), PRMT8(1) 1023131 13 9 10 15 2 9 0 1 1 0 0.995 1.000 1.000 460 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 16 CHST11(1), CHST12(4), CHST13(2), CHSY1(3), DSE(8), UST(1), XYLT1(4), XYLT2(5) 1072776 28 9 20 24 6 10 0 12 0 0 0.997 1.000 1.000 461 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS1(2), DHRS2(2), DHRSX(1), ESCO1(1), PNPLA3(5) 1190333 11 9 9 14 1 4 0 6 0 0 0.999 1.000 1.000 462 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 17 AADAC(2), AOC2(2), AOC3(4), DDHD1(1), ESCO1(1), LIPA(3), PLA1A(2), PNPLA3(5) 1770505 20 9 17 10 3 9 0 8 0 0 0.828 1.000 1.000 463 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 66 MRPS7(1), RPL10L(2), RPL13(1), RPL14(1), RPL3(1), RPL37(1), RPL3L(2), RPL6(1) 1559020 10 9 10 31 5 3 1 0 1 0 1.000 1.000 1.000 464 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(1), CD3D(1), CD3G(2), CD58(1), IL3(3), IL6(2), KITLG(1) 460709 11 9 9 17 1 5 0 3 2 0 1.000 1.000 1.000 465 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(2), LEPR(10), PRKAA1(1) 1041897 13 9 7 14 1 3 6 3 0 0 0.996 1.000 1.000 466 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), ECHS1(1), EHHADH(3) 896625 18 9 17 19 4 8 0 5 1 0 0.999 1.000 1.000 467 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 19 BCL2(1), BIRC2(1), CASP7(3), CASP8(3), CASP9(4), DFFA(1), ENDOG(2) 991943 15 9 12 19 2 5 1 6 1 0 1.000 1.000 1.000 468 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(2), BIN1(1), EPS15(3), PPP3CA(1), PPP3CC(1), SYNJ1(2), SYNJ2(3) 1686103 13 9 10 32 1 7 0 3 2 0 1.000 1.000 1.000 469 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(1), ENO3(2), FARS2(1), GOT2(4), PAH(1), TAT(2) 595778 11 9 9 14 2 4 0 5 0 0 0.999 1.000 1.000 470 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 28 ANXA2(1), ANXA4(2), EDNRA(1), HPGD(1), PLA2G4A(1), PTGFR(1), PTGIR(2), PTGIS(1), PTGS1(3), PTGS2(1), TBXAS1(5) 1586711 19 9 17 34 6 3 0 10 0 0 1.000 1.000 1.000 471 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 ADAM17(1), APC(4), BTRC(1), DVL1(1), FZD1(1), NOTCH1(2), PSEN1(1) 1638098 11 9 11 29 3 3 1 3 1 0 1.000 1.000 1.000 472 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 BCAR1(2), CDKN1B(1), GRB2(1), ILK(1), PDPK1(1), PIK3CA(2), PTEN(2), PTK2(2), SOS1(1) 1450523 13 9 13 36 3 3 0 4 3 0 1.000 1.000 1.000 473 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 11 ATM(8), CDC25C(4), MYT1(1), RB1(1) 1234865 14 9 11 19 3 7 0 3 1 0 1.000 1.000 1.000 474 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 13 ACE(2), CD44(3), CSF1(2), IL6R(2), SELL(3), TGFB2(1), TNF(3), TNFRSF1B(3) 893988 19 9 15 25 2 8 2 6 1 0 1.000 1.000 1.000 475 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT2(1), CDKN1A(4), ELK1(1), GRB2(1), MAP2K1(2), NGFR(2), NTRK1(3), PIK3CA(2), PIK3CD(1), SOS1(1) 1236506 18 9 17 25 5 5 2 4 2 0 1.000 1.000 1.000 476 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(4), CKM(1), GPT(1), LDHA(1), NCL(4) 663110 11 9 10 18 3 4 0 1 3 0 1.000 1.000 1.000 477 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CDC25C(4), CSK(3), GRB2(1), PTPRA(2) 678402 10 9 9 13 3 1 1 2 3 0 0.999 1.000 1.000 478 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 F13B(1), HSD17B1(2), HSD17B4(4), HSD17B7(4), HSD3B1(2), HSD3B2(2) 589135 15 9 12 17 3 9 2 1 0 0 0.996 1.000 1.000 479 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(1), CD3D(1), CD3G(2), ICAM1(6), ITGAL(1), PTPRC(1) 767381 12 9 9 20 1 4 0 6 1 0 1.000 1.000 1.000 480 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(1), CD3D(1), CD3G(2), ICAM1(6), ITGAL(1), PTPRC(1) 809519 12 9 9 18 1 4 0 6 1 0 1.000 1.000 1.000 481 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 DPM2(1), GRB2(1), KLK2(1), NTRK1(3), PIK3CA(2), PLCG1(3), SOS1(1) 1141683 12 9 11 22 2 4 2 3 1 0 1.000 1.000 1.000 482 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3) 588587 14 8 13 16 4 5 0 4 1 0 0.999 1.000 1.000 483 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(2), AGT(4), AGTR1(2), AGTR2(3), KNG1(6) 741110 17 8 14 17 4 3 0 10 0 0 0.998 1.000 1.000 484 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 CHRNG(1), MUSK(5), PIK3CA(2), PTK2(2), PTK2B(4), RAPSN(1), TERT(1) 1234919 16 8 13 34 5 3 0 4 4 0 1.000 1.000 1.000 485 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 11 ARFGAP3(2), CLTB(1), COPA(1), GBF1(2), GPLD1(5) 1141674 11 8 8 17 5 4 0 1 1 0 1.000 1.000 1.000 486 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A2(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3) 588587 14 8 13 16 4 5 0 4 1 0 0.999 1.000 1.000 487 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 13 DHCR7(1), FDFT1(2), HMGCR(1), LSS(3), MVK(2), NQO2(3), SQLE(1) 782698 13 8 12 29 3 4 3 1 2 0 1.000 1.000 1.000 488 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CAMK1G(1), CAMK2G(1), CAMK4(1), CAMKK1(1), CAMKK2(5) 875442 9 8 7 26 2 2 0 4 1 0 1.000 1.000 1.000 489 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(8), CDC25C(4), MYT1(1) 1014844 13 8 10 14 3 7 0 3 0 0 0.995 1.000 1.000 490 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLD1(2), POLE(4), POLG(2), POLL(1), POLQ(15) 1233070 24 8 20 24 4 10 2 7 1 0 0.999 1.000 1.000 491 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 10 CASP7(3), DFFA(1), ENDOG(2), GZMB(5), HMGB2(1), TOP2A(3), TOP2B(2) 775933 17 8 13 17 1 3 2 10 1 0 1.000 1.000 1.000 492 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(1), CDKN1A(4), EPOR(1), JAK2(2), NFKB1(3), NFKBIA(3) 967345 14 8 12 18 2 3 0 6 3 0 1.000 1.000 1.000 493 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(4), EGFR(4), ERBB3(1), NRG1(4) 739620 13 8 10 14 2 6 0 5 0 0 0.998 1.000 1.000 494 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ADAM17(1), ERBB4(4), NRG2(1), NRG3(2), PSEN1(1) 663032 9 8 8 15 2 1 0 4 2 0 1.000 1.000 1.000 495 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 GPD2(3), SDHA(6), SDHC(1), UQCRC1(1) 473181 11 8 9 18 6 1 0 3 1 0 1.000 1.000 1.000 496 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 11 GABRA1(2), GABRA2(2), GABRA3(1), GABRA5(1), GABRA6(3), GPHN(2), UBQLN1(1) 851200 12 8 11 15 0 7 0 5 0 0 1.000 1.000 1.000 497 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(5), GALNS(2), GLB1(1), GUSB(1), HEXB(5), IDS(1), IDUA(5), LCT(3), NAGLU(3) 1077485 26 8 17 38 12 9 2 3 0 0 1.000 1.000 1.000 498 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(1), CYSLTR2(2), GPR171(1), GPR18(1), GPR34(1), GPR39(3), GPR45(1), GPR68(1), GPR75(1) 715879 12 8 11 12 1 9 0 1 1 0 0.986 1.000 1.000 499 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3) 631532 14 8 13 28 3 5 0 5 1 0 1.000 1.000 1.000 500 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 16 BHMT(1), CBS(2), CTH(2), DNMT1(2), DNMT3B(1), MAT2B(1), MTR(4), SRM(1), TAT(2) 1486640 16 8 13 23 2 8 0 4 2 0 1.000 1.000 1.000 501 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 HK1(1), HK2(4), HK3(1), IMPA2(1), PGM1(4), PGM3(1) 877141 12 8 10 29 2 7 0 2 1 0 1.000 1.000 1.000 502 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(7), ACOX3(1), PLA2G2D(1), PLA2G3(4), PLA2G4A(1), PLA2G5(1) 790092 15 8 13 12 5 3 1 6 0 0 0.980 1.000 1.000 503 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 15 B4GALNT1(3), GLB1(1), HEXB(5), LCT(3), SLC33A1(1), ST6GALNAC3(1) 1139774 14 8 10 23 1 9 1 3 0 0 1.000 1.000 1.000 504 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH4(4), ADH7(2), ADHFE1(1), ALDH1A3(3), ALDH1B1(3), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(1), ALDH9A1(3) 978665 21 8 17 26 3 7 1 7 3 0 1.000 1.000 1.000 505 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(2), ACSS1(2), ACSS2(1), IDH1(1), MDH2(5) 964320 11 8 7 15 3 4 1 3 0 0 0.999 1.000 1.000 506 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(3), POLR1B(2), POLR2B(1), POLR2E(1), POLR3A(4) 1688473 11 8 10 41 2 4 0 5 0 0 1.000 1.000 1.000 507 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 34 GOSR2(2), SNAP25(1), STX16(2), STX18(1), STX2(2), TSNARE1(9), VTI1A(1) 1200905 18 8 15 25 5 4 1 5 3 0 1.000 1.000 1.000 508 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 11 BLVRA(1), IL10RA(4), IL10RB(2), IL1A(2), IL6(2), JAK1(2), STAT1(1), TNF(3) 737796 17 8 16 25 4 7 2 3 1 0 1.000 1.000 1.000 509 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 ACAT1(2), CCL2(1), CSF1(2), IL6(2), LDLR(3), LPL(1) 385027 11 8 7 15 1 4 2 3 1 0 1.000 1.000 1.000 510 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 CDC25C(4), GNAS(1), GNGT1(1), MYT1(1), PRKACG(2), RPS6KA1(2) 1534712 11 8 8 37 5 0 0 6 0 0 1.000 1.000 1.000 511 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(3), ICAM1(6), ITGAL(1), ITGAM(6), SELE(3), SELL(3) 785544 22 8 16 23 3 14 0 5 0 0 0.999 1.000 1.000 512 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 IFNAR1(4), IFNAR2(3), MAPK8(1), NFKB1(3), TNFRSF11A(3), TRAF6(1) 800175 15 8 10 10 3 4 1 5 2 0 0.950 1.000 1.000 513 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 MMP14(4), MMP2(1), MMP9(3), RECK(2), TIMP2(1), TIMP4(1) 567106 12 8 9 24 4 1 2 4 1 0 1.000 1.000 1.000 514 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 7 ACP2(3), ACP5(1), ENPP1(3), ENPP3(3), FLAD1(1) 549141 11 8 7 13 3 2 2 4 0 0 0.998 1.000 1.000 515 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDKN1A(4), NEK1(8) 565779 12 8 9 11 3 6 0 3 0 0 0.983 1.000 1.000 516 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 CISH(1), JAK1(2), JAK2(2), JAK3(2), PIAS1(1), PTPRU(4), SOAT1(1) 1038087 13 8 12 21 4 4 1 4 0 0 1.000 1.000 1.000 517 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 HK1(1), HK2(4), HK3(1), PGM1(4), PGM3(1) 766618 11 8 9 22 2 6 0 2 1 0 1.000 1.000 1.000 518 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ALDH18A1(2), CKM(1), CPS1(5), GAMT(1), OTC(4) 1372499 13 8 8 20 3 5 0 4 1 0 1.000 1.000 1.000 519 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(2), CYP2E1(1), PTGS1(3), PTGS2(1) 381456 7 7 6 8 1 1 0 5 0 0 0.998 1.000 1.000 520 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(15), PRKACG(2) 742959 17 7 13 15 6 4 0 7 0 0 0.995 1.000 1.000 521 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 EPRS(2), FARS2(1), GARS(1), IARS(2), LARS(4), QARS(1), RARS(2), SARS(1), WARS2(1) 2301515 15 7 10 48 1 10 0 4 0 0 1.000 1.000 1.000 522 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 15 CCL2(1), MAPK8(1), PLCG1(3), PTK2B(4) 921581 9 7 6 21 0 1 3 2 3 0 1.000 1.000 1.000 523 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADRB2(3), CFTR(5), GNAS(1), PRKACG(2) 971932 11 7 7 30 1 5 0 3 2 0 1.000 1.000 1.000 524 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 DHCR7(1), FDFT1(2), HMGCR(1), LSS(3), MVK(2), NSDHL(1), SQLE(1) 977112 11 7 10 31 3 4 2 1 1 0 1.000 1.000 1.000 525 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 7 GABRA1(2), GABRA2(2), GABRA3(1), GABRA5(1), GABRA6(3) 394483 9 7 8 8 0 7 0 2 0 0 0.976 1.000 1.000 526 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 NFKB1(3), TNF(3), XDH(6) 738471 12 7 9 11 1 7 0 1 3 0 0.989 1.000 1.000 527 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 12 A4GALT(3), FUT1(1), FUT2(1), GBGT1(4), HEXB(5), NAGA(1) 682461 15 7 9 17 1 10 0 2 2 0 0.998 1.000 1.000 528 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 11 GABBR1(1), GPRC5C(2), GRM1(2), GRM2(1), GRM4(1), GRM5(1), GRM7(1) 1225425 9 7 9 36 2 3 0 4 0 0 1.000 1.000 1.000 529 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 12 ARNT(1), ASPH(1), EP300(5), LDHA(1) 1216167 8 7 7 17 1 5 0 2 0 0 1.000 1.000 1.000 530 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 13 A4GALT(3), B3GALT5(1), FUT1(1), FUT2(1), GBGT1(4), HEXB(5), NAGA(1) 727437 16 7 10 19 1 11 0 2 2 0 0.999 1.000 1.000 531 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 12 ECHS1(1), EHHADH(3), HSD17B4(4), SIRT1(2), SIRT5(1) 827082 11 7 10 15 0 6 1 3 1 0 0.999 1.000 1.000 532 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 GRB2(1), IRS1(2), MAP2K1(2), PIK3CA(2), RAF1(4), SOS1(1) 1373965 12 7 12 25 2 6 1 1 2 0 1.000 1.000 1.000 533 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 9 B3GNT1(1), B4GALT2(1), B4GALT3(2), B4GALT5(1), FUT8(4) 518973 9 7 8 11 4 0 0 5 0 0 0.999 1.000 1.000 534 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 BHMT(1), CBS(2), CTH(2), DNMT1(2), DNMT3B(1), MAT2B(1), MTR(4) 1280246 13 7 10 20 1 7 0 3 2 0 1.000 1.000 1.000 535 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(7), GAD1(2), HDC(4), TH(3) 442339 16 7 9 16 11 0 1 4 0 0 0.993 1.000 1.000 536 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CAMK1G(1), CAMK2G(1), CAMK4(1), MEF2B(3), MEF2C(1), PPARA(1), PPP3CA(1), PPP3CC(1), SLC2A4(1) 1563287 11 7 10 42 3 3 0 3 2 0 1.000 1.000 1.000 537 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 12 ADRB2(3), GNAS(1), PLCE1(8), PRKACG(2) 1114755 14 7 12 32 2 6 1 5 0 0 1.000 1.000 1.000 538 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 16 PSMB2(1), PSMB4(1), PSMB5(2), PSMB7(1), PSMB8(1), PSMB9(2) 604061 8 7 6 14 4 2 0 1 1 0 1.000 1.000 1.000 539 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CDC25C(4), SHH(1), XPO1(3) 639780 8 7 6 11 6 0 0 2 0 0 0.998 1.000 1.000 540 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RANBP2(10) 586001 10 7 6 8 1 6 1 2 0 0 0.910 1.000 1.000 541 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 13 CCND1(1), CDKN1A(4), CDKN1B(1), CDKN2A(1), E2F1(2), E2F2(3) 498773 12 7 10 14 2 2 1 5 2 0 0.999 1.000 1.000 542 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 CASP8(3), TNF(3), TNFRSF1B(3) 611399 9 7 8 15 1 2 0 4 2 0 1.000 1.000 1.000 543 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 CISH(1), JAK1(2), JAK2(2), PTPRU(4), STAT1(1) 836344 10 7 9 25 2 4 0 4 0 0 1.000 1.000 1.000 544 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 6 JAK1(2), JAK2(2), JAK3(2), TYK2(3) 779117 9 7 9 18 4 1 0 4 0 0 1.000 1.000 1.000 545 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CSF1(2), CSF2(1), IL11(1), IL3(3), IL6(2), IL9(1) 460993 10 7 7 21 2 5 2 1 0 0 1.000 1.000 1.000 546 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD3D(1), CD3G(2), IL2RA(1), TGFB2(1), TGFBR3(2) 785579 7 7 7 15 1 2 0 2 2 0 1.000 1.000 1.000 547 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 LPL(1), PPARG(3), TNF(3) 416737 7 7 6 11 0 1 0 4 2 0 1.000 1.000 1.000 548 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAD(2), ALAS2(1), CPO(5), UROS(1) 621764 9 6 7 16 2 5 0 2 0 0 1.000 1.000 1.000 549 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT1(2), ACAT2(1), ACYP1(1), ECHS1(1), EHHADH(3) 570606 8 6 7 10 0 4 0 4 0 0 0.999 1.000 1.000 550 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ARPC1B(3), PIK3CA(2), RAC1(1), WASL(1) 981086 7 6 6 10 2 1 0 4 0 0 0.999 1.000 1.000 551 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 HS3ST1(1), HS3ST3B1(1), XYLT1(4), XYLT2(5) 514100 11 6 9 24 2 3 0 5 1 0 1.000 1.000 1.000 552 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 8 ACAA1(3), ACAT1(2), ACAT2(1), ECHS1(1), EHHADH(3), HADHB(1) 559011 11 6 9 11 0 5 0 5 1 0 0.996 1.000 1.000 553 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(4), CYP11B2(5), HSD3B1(2), HSD3B2(2) 502862 13 6 10 16 6 3 3 0 1 0 0.998 1.000 1.000 554 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 GRB2(1), PTK2B(4), SOS1(1) 636551 6 6 4 17 0 1 0 1 4 0 1.000 1.000 1.000 555 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAD(2), ALAS2(1), CPOX(1), PPOX(2), UROS(1) 568954 7 6 7 10 3 1 0 3 0 0 1.000 1.000 1.000 556 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 HS3ST1(1), HS3ST3B1(1), XYLT1(4), XYLT2(5) 514100 11 6 9 24 2 3 0 5 1 0 1.000 1.000 1.000 557 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 6 EPHX2(6), HSD3B7(2) 301395 8 6 6 11 1 4 0 0 3 0 0.998 1.000 1.000 558 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 4 DDC(3), GOT2(4), TAT(2) 262381 9 6 8 11 4 2 0 3 0 0 0.997 1.000 1.000 559 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(1), SEC61A2(1), SRP68(1), SRP72(2), SRPR(1) 542736 6 6 6 13 3 1 0 1 1 0 1.000 1.000 1.000 560 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(1), ANKRD1(1), IL1A(2), IL1R1(1), MYOG(1), NR4A3(1), WDR1(1) 810356 8 6 8 21 3 1 0 3 1 0 1.000 1.000 1.000 561 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 13 GH1(2), GHR(2), PIK3CA(2) 960523 6 6 6 19 0 2 0 2 2 0 1.000 1.000 1.000 562 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDHB(1), CBS(2), CTH(2), MUT(5) 364148 10 6 7 6 6 1 0 3 0 0 0.834 1.000 1.000 563 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 9 CTSD(1), GREB1(6), TUBA8(3) 746783 10 6 9 12 6 2 0 2 0 0 0.992 1.000 1.000 564 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 7 ADORA1(1), ADORA3(4), P2RY1(1), P2RY6(1) 372877 7 6 6 6 2 1 0 4 0 0 0.943 1.000 1.000 565 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 11 BCL10(2), BCL2(1), CASP9(4) 777411 7 6 5 15 1 4 1 1 0 0 1.000 1.000 1.000 566 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ARPC1B(3), RAC1(1), WASF1(1), WASL(1) 602723 6 6 5 6 3 0 0 3 0 0 0.979 1.000 1.000 567 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CTH(2), GOT2(4), LDHA(1) 493188 7 5 5 12 1 1 0 5 0 0 1.000 1.000 1.000 568 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 ADRB2(3), GNAS(1), GNGT1(1), NFKB1(3), NPPA(1), PIK3CA(2) 1339315 11 5 9 23 3 4 0 2 2 0 1.000 1.000 1.000 569 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 7 COQ5(2), COQ6(2), COQ7(2) 261070 6 5 3 6 4 2 0 0 0 0 0.958 1.000 1.000 570 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT2(4), TAT(2) 191112 6 5 5 9 2 1 0 3 0 0 0.999 1.000 1.000 571 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 9 B3GALT5(1), B3GNT5(2), FUT1(1), FUT2(1), FUT3(6) 472874 11 5 8 8 2 3 0 6 0 0 0.958 1.000 1.000 572 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDFT1(2), GGPS1(1), IDI2(2), SQLE(1) 320695 6 5 6 12 0 0 2 1 3 0 1.000 1.000 1.000 573 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(2), CYP2C9(5) 144812 7 5 5 4 5 1 0 1 0 0 0.924 1.000 1.000 574 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 21 PSMB2(1), PSMB4(1), PSMB5(2), PSMB7(1), PSMD13(1), PSMD2(1) 1133012 7 5 6 17 2 3 0 1 1 0 1.000 1.000 1.000 575 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNGR2(2), JAK1(2), JAK2(2), STAT1(1) 592569 7 5 6 21 1 4 0 2 0 0 1.000 1.000 1.000 576 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 3 PLCG1(3), PTK2B(4) 439247 7 5 4 16 0 1 2 1 3 0 1.000 1.000 1.000 577 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 7 OGDH(2), SDHA(6) 615626 8 5 6 22 5 0 0 3 0 0 1.000 1.000 1.000 578 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 ADAM17(1), FURIN(2), NOTCH1(2), PSEN1(1) 740733 6 5 6 12 4 1 0 0 1 0 0.999 1.000 1.000 579 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSS(1), POLD1(2), POLG(2), RRM1(1), SRM(1) 957892 7 5 6 15 2 2 1 2 0 0 1.000 1.000 1.000 580 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 IDH1(1), MDH2(5) 647342 6 5 4 9 1 4 1 0 0 0 0.996 1.000 1.000 581 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(2), POLR2B(1), POLR2E(1), POLRMT(4) 997709 8 5 8 39 1 4 0 3 0 0 1.000 1.000 1.000 582 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 LDLR(3), MBTPS1(1), SCAP(3), SREBF1(1), SREBF2(5) 931385 13 5 8 13 4 4 0 5 0 0 0.991 1.000 1.000 583 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 6 MYC(7), SP1(1), SP3(2) 453360 10 5 10 9 0 5 1 4 0 0 0.971 1.000 1.000 584 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 IARS(2), LARS(4), PDHA2(2) 724252 8 5 5 24 0 7 1 0 0 0 1.000 1.000 1.000 585 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH4(4), ADH7(2), ADHFE1(1) 405117 7 4 4 11 0 2 1 2 2 0 0.999 1.000 1.000 586 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 GNAS(1), GNGT1(1), PPP2CA(1), PRKAA1(1), PRKACG(2) 1146405 6 4 5 21 2 2 0 2 0 0 1.000 1.000 1.000 587 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 FABP6(2), LDLR(3) 388880 5 4 3 7 1 4 0 0 0 0 0.983 1.000 1.000 588 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 PGLYRP2(7) 132232 7 4 5 4 4 3 0 0 0 0 0.794 1.000 1.000 589 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1G(1), HDAC9(1), MEF2B(3), MEF2C(1) 634155 6 4 5 23 2 1 0 2 1 0 1.000 1.000 1.000 590 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 PARK2(3), SNCAIP(1) 451128 4 4 4 5 0 0 0 4 0 0 0.996 1.000 1.000 591 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 18 PSMB2(1), PSMB4(1), PSMB5(2), PSMB7(1), RPN2(1) 910123 6 4 5 14 2 3 0 0 1 0 1.000 1.000 1.000 592 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(1), BMPR1A(3) 452082 4 4 3 9 2 0 0 2 0 0 1.000 1.000 1.000 593 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT1(2), ACAT2(1), OXCT1(2) 248068 5 4 4 5 1 1 1 2 0 0 0.975 1.000 1.000 594 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 14 NDUFS1(1), NDUFS2(3) 483216 4 4 3 8 1 0 0 3 0 0 1.000 1.000 1.000 595 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 22 NRF1(1), UBE2D3(1), UBE2E3(1), UBE2J1(1) 748436 4 4 4 18 1 1 0 1 1 0 1.000 1.000 1.000 596 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 GNAS(1), GNGT1(1), PRKACG(2) 732388 4 3 3 19 2 0 0 2 0 0 1.000 1.000 1.000 597 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 B3GNT1(1), FUT1(1), FUT2(1) 455083 3 3 3 6 2 0 0 1 0 0 0.996 1.000 1.000 598 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 ECHS1(1), EHHADH(3) 356381 4 3 4 4 0 3 0 1 0 0 0.933 1.000 1.000 599 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 OPRK1(1), PRKACG(2) 943548 3 3 2 27 1 0 0 2 0 0 1.000 1.000 1.000 600 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(1), ENO1(1), HK1(1) 674641 3 3 3 9 0 2 0 1 0 0 1.000 1.000 1.000 601 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 GNAS(1), GNGT1(1), PRKACA(1) 489989 3 3 3 6 3 0 0 0 0 0 0.998 1.000 1.000 602 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALT(2), UXS1(1) 371833 3 3 2 8 0 3 0 0 0 0 0.999 1.000 1.000 603 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALT(2), UXS1(1) 296956 3 3 2 8 0 3 0 0 0 0 0.999 1.000 1.000 604 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 BCL2(1), CASP8(3) 276675 4 3 4 11 2 0 0 1 1 0 1.000 1.000 1.000 605 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CD36(1), THBS1(5) 517679 6 3 4 15 0 4 0 1 1 0 1.000 1.000 1.000 606 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 KEAP1(1), MAPK8(1) 680914 2 2 2 13 0 1 1 0 0 0 1.000 1.000 1.000 607 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 2 FAH(1), HGD(1) 128704 2 2 2 3 1 0 0 1 0 0 0.968 1.000 1.000 608 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 PLCD1(2) 372890 2 2 1 13 2 0 0 0 0 0 1.000 1.000 1.000 609 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 6 ST6GALNAC2(1) 302151 1 1 1 5 1 0 0 0 0 0 0.999 1.000 1.000 610 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A2(1) 273918 1 1 1 7 1 0 0 0 0 0 1.000 1.000 1.000 611 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 RAB9A(1) 312573 1 1 1 6 0 1 0 0 0 0 1.000 1.000 1.000 612 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 FMOD(1) 260296 1 1 1 5 0 0 1 0 0 0 0.999 1.000 1.000 613 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 121917 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 614 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 36378 0 0 0 3 0 0 0 0 0 0 1.000 1.000 1.000 615 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 156741 0 0 0 3 0 0 0 0 0 0 1.000 1.000 1.000 616 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 109350 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000