rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(3), CCNA2(1), CCND1(4), CCNE1(2), CCNE2(2), CDK2(1), CDK4(1), CDKN1B(4), CDKN2A(6), E2F1(1), E2F2(1), E2F4(1), PRB1(2) 10572211 29 25 28 0 5 1 6 7 10 0 0.000290 0.00649 1.000 2 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(5), CYP2C9(3) 2399460 8 8 8 0 4 2 0 1 1 0 0.0995 0.00989 1.000 3 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 14 ARF1(1), CCND1(4), CDK2(1), CDK4(1), CDKN1A(2), CDKN1B(4), CDKN2A(6), CFL1(1), E2F1(1), E2F2(1), MDM2(5), PRB1(2) 8951305 29 24 28 3 6 2 5 5 11 0 0.0194 0.0290 1.000 4 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(3) 854859 3 3 3 1 2 1 0 0 0 0 0.562 0.102 1.000 5 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3D(1), CD3E(2), CD3G(1) 1351852 4 4 4 1 0 1 1 1 1 0 0.574 0.113 1.000 6 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD28(2), CD4(2), HLA-DRA(4), HLA-DRB1(1) 2824898 9 7 8 1 4 1 0 3 1 0 0.158 0.169 1.000 7 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(2), GSTZ1(3), HGD(5) 2645677 10 6 10 2 4 0 1 2 3 0 0.308 0.179 1.000 8 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP1(1), ACPP(4), ACPT(2), ENPP1(5), ENPP3(2), FLAD1(2), TYR(5) 11508628 21 18 21 1 8 2 3 6 2 0 0.0136 0.182 1.000 9 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(6), IFNG(2), IL12B(4), IL18(3) 3542953 15 11 15 3 4 2 2 5 2 0 0.254 0.188 1.000 10 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCL11(2), CCL5(1), CCR3(2), CSF2(2), HLA-DRA(4), HLA-DRB1(1), IL3(2), IL5(1) 3611520 15 11 15 3 4 3 1 4 3 0 0.226 0.215 1.000 11 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 8 CCNA1(3), CCNE1(2), CDC34(2), CDK2(1), CUL1(4), E2F1(1), SKP2(3), TFDP1(1) 8080361 17 15 17 2 2 3 3 6 3 0 0.137 0.293 1.000 12 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 11 CCNE1(2), CDK2(1), CDKN1B(4), CUL1(4), E2F1(1), RBX1(1), SKP2(3), TFDP1(1), UBE2M(2) 8096124 19 17 19 3 1 4 4 5 5 0 0.153 0.315 1.000 13 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDFT1(1), FDPS(3), GGPS1(1), IDI1(2), IDI2(1), SQLE(1) 5066632 9 8 9 0 1 0 5 1 2 0 0.0921 0.318 1.000 14 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDFT1(1), FDPS(3), IDI1(2), SQLE(1) 3785468 7 6 7 0 1 0 4 0 2 0 0.163 0.345 1.000 15 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(3), IL13RA2(1), IL4R(10), JAK1(3), JAK2(5), TYK2(10) 12457734 32 25 32 4 11 1 3 10 7 0 0.0251 0.354 1.000 16 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(3), IL13RA2(1), IL4R(10), JAK1(3), JAK2(5), TYK2(10) 12457734 32 25 32 4 11 1 3 10 7 0 0.0251 0.354 1.000 17 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(2), PGLYRP2(3) 2158410 5 5 5 1 3 1 0 1 0 0 0.461 0.362 1.000 18 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(5), SUCLA2(1) 2508918 6 5 6 0 2 2 0 2 0 0 0.133 0.376 1.000 19 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 7 CCNE1(2), CDC34(2), CDK2(1), CUL1(4), E2F1(1), FBXW7(5), TFDP1(1) 7751397 16 14 16 2 4 3 1 5 3 0 0.116 0.378 1.000 20 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 FABP6(2), LDLR(3), NR0B2(1), NR1H3(5), NR1H4(3), RXRA(4) 6471064 18 17 16 4 7 4 2 4 1 0 0.138 0.419 1.000 21 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALT(1), TGDS(2), UGDH(1), UXS1(4) 4580573 8 7 8 0 1 1 3 1 2 0 0.0831 0.430 1.000 22 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCL11(2), CCR3(2), CD4(2), HLA-DRA(4), HLA-DRB1(1), IL1B(3), IL5(1), IL5RA(3), IL6(2) 6346628 20 15 20 4 6 4 0 8 2 0 0.137 0.439 1.000 23 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RANBP1(1), RANBP2(12), RANGAP1(2) 9998529 15 13 15 1 3 2 3 5 2 0 0.0379 0.478 1.000 24 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(5), TPI1(1) 1956213 6 3 6 0 0 3 1 2 0 0 0.133 0.488 1.000 25 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(2), GOT2(1), TAT(3) 3119700 6 5 5 1 3 1 1 1 0 0 0.366 0.510 1.000 26 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(5), GOT1(2), GOT2(1), TAT(3), TYR(5) 5582938 16 12 15 3 8 1 3 4 0 0 0.216 0.531 1.000 27 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 BCL2(2), CASP8(2), CFL1(1), CFLAR(1) 4596535 6 6 6 0 0 1 1 1 3 0 0.228 0.573 1.000 28 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP1(1), ACP6(2), ACPP(4), ACPT(2), ENPP1(5), ENPP3(2), FLAD1(2), LHPP(1), MTMR1(6), MTMR2(3), MTMR6(1), TYR(5) 17839871 34 28 34 4 11 5 6 8 4 0 0.0191 0.585 1.000 29 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ2(1), COQ3(2), COQ5(3), COQ6(2), NDUFA12(1), NDUFB11(1) 4785378 10 8 10 2 2 4 0 2 2 0 0.358 0.632 1.000 30 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(2), ALPP(7), ALPPL2(6), DHFR(1), FPGS(2), GGH(1), SPR(1) 7761312 20 18 18 5 10 3 4 1 2 0 0.152 0.640 1.000 31 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(9), PDXK(1), PSAT1(4) 5756041 14 11 12 4 7 5 0 2 0 0 0.257 0.642 1.000 32 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALT(1), TGDS(2), UGDH(1), UGP2(1), UXS1(4) 5827733 9 7 9 0 1 1 3 2 2 0 0.0676 0.644 1.000 33 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDHB(2), BCKDK(3), CBS(5), CTH(2), MUT(2) 5829980 14 8 14 1 3 5 1 4 1 0 0.0414 0.651 1.000 34 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B4GALT2(1), FUT8(7), ST3GAL1(3), ST3GAL2(1), ST3GAL3(2), ST3GAL4(3) 9345226 17 16 17 3 6 2 3 3 3 0 0.161 0.665 1.000 35 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 11 AKT1(2), CAT(3), GH1(2), GHR(4), IGF1(3), IGF1R(10), SHC1(1), SOD2(1) 11324958 26 20 26 4 4 4 5 8 5 0 0.0411 0.665 1.000 36 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(1), CD3D(1), CD3E(2), CD3G(1), CD4(2), CD58(2), CD8A(1), IL3(2), IL6(2), KITLG(3) 7347641 17 13 17 3 3 2 2 8 2 0 0.188 0.678 1.000 37 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(1), CDO1(1), GAD1(3), GAD2(1), GGT1(3) 6836871 9 8 9 0 2 3 2 2 0 0 0.0365 0.689 1.000 38 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(1), SRP54(2), SRP68(2), SRP72(3), SRPR(7) 8951311 15 10 15 1 5 1 3 3 3 0 0.0760 0.707 1.000 39 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(2), LPL(2), NR3C1(3), PPARG(3), RETN(1), RXRA(4), TNF(1) 6893647 16 15 16 5 4 3 1 5 3 0 0.375 0.711 1.000 40 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 5 AKT1(2), PLCB1(4), PLCG1(12), PRKCA(6), VAV1(9) 10750032 33 28 31 9 8 4 4 11 5 1 0.321 0.762 1.000 41 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(5), ALDOA(1), ALDOB(2), TPI1(1) 4641983 9 5 9 1 0 4 1 3 1 0 0.204 0.762 1.000 42 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(2), GLS(4), GLUD1(4), OAT(1), PRODH(1) 6560824 12 9 12 3 3 1 0 5 3 0 0.418 0.781 1.000 43 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(3), GNB1(1), HTR2C(4), PLCB1(4), TUB(4) 8492989 16 13 16 4 5 3 0 6 2 0 0.352 0.797 1.000 44 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ASL(2), CPS1(8), GLS(4), GLUD1(4), GOT1(2) 9251054 20 13 20 3 4 1 2 7 6 0 0.232 0.799 1.000 45 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3D(1), CD3E(2), CD3G(1), CD4(2), FYN(2), HLA-DRA(4), HLA-DRB1(1), LCK(1), PTPRC(9), ZAP70(8) 10746799 31 24 31 8 11 5 3 10 2 0 0.234 0.808 1.000 46 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 CCL2(1), IL6(2), LDLR(3), LPL(2) 6327852 8 8 8 2 0 1 0 6 1 0 0.620 0.809 1.000 47 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 20 CCNA1(3), CCNB1(2), CCND1(4), CCND2(2), CCND3(1), CCNE1(2), CCNH(2), CDC25A(1), CDK2(1), CDK4(1), CDK7(1), CDKN1A(2), CDKN1B(4), CDKN2A(6), CDKN2B(2), E2F1(1), RBL1(6), TFDP1(1) 16495022 42 31 41 6 7 5 7 13 10 0 0.0243 0.811 1.000 48 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAD(2), ALAS1(2), ALAS2(1), FECH(2), HMBS(1), PPOX(2), UROD(1), UROS(1) 9006522 12 9 12 1 2 3 2 3 2 0 0.0953 0.813 1.000 49 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 14 APAF1(3), ATM(12), BAX(1), BCL2(2), CCND1(4), CCNE1(2), CDK2(1), CDK4(1), CDKN1A(2), E2F1(1), MDM2(5), TIMP3(2) 18486757 36 26 36 6 6 4 7 11 8 0 0.121 0.817 1.000 50 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(1), CDC25B(1), CDK7(1), CDKN1A(2), CHEK1(6), NEK1(4), WEE1(2) 8250713 17 15 17 4 5 4 2 4 2 0 0.488 0.820 1.000 51 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(9), CD38(1), ENPP1(5), ENPP3(2), NADSYN1(5), NMNAT1(1), NNMT(1), NNT(6), NT5C(3), NT5E(3), NT5M(1) 17273748 37 28 35 6 8 11 6 9 3 0 0.0144 0.823 1.000 52 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CCR5(1), CD28(2), CD3D(1), CD3E(2), CD3G(1), CD4(2) 3817233 9 8 8 3 4 1 1 2 1 0 0.490 0.834 1.000 53 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 10 CBL(2), CSF1R(5), EGF(10), MET(13), PRKCA(6), SH3GLB1(3), SH3KBP1(5), SRC(2) 17227778 46 27 46 11 15 3 5 15 7 1 0.135 0.838 1.000 54 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(3), CHRNA1(4) 3862566 7 7 7 3 2 2 1 1 1 0 0.585 0.845 1.000 55 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 5 NFYA(1), NFYB(1), SP1(1), SP3(5) 5810988 8 7 8 2 1 1 2 2 2 0 0.574 0.848 1.000 56 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(3), JAK2(5), JAK3(5), MAPK1(4), MAPK3(2), STAT3(3), TYK2(10) 14000308 32 22 32 4 12 2 3 8 6 1 0.0325 0.854 1.000 57 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 ATP6V0C(1), GGT1(3), SHMT1(2) 4971666 6 5 6 1 2 2 2 0 0 0 0.240 0.860 1.000 58 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 16 AKT1(2), EIF2S2(2), EIF2S3(3), EIF4E(2), GSK3B(1), IGF1(3), IGF1R(10), INPPL1(8), PPP2CA(4), RPS6KB1(2) 17933341 37 26 37 5 6 3 7 12 9 0 0.0280 0.861 1.000 59 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(5), PARK2(2), SNCA(1), SNCAIP(1), UBE2G2(1), UBE2L6(1) 7637986 11 11 11 3 7 1 0 2 1 0 0.294 0.865 1.000 60 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(4), ME1(2), PC(4), PDHA1(6), SLC25A1(1), SLC25A11(1) 10999700 18 17 16 4 2 4 0 7 5 0 0.258 0.878 1.000 61 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 11 ACTR2(2), ACTR3(1), ARPC1A(1), ARPC1B(2), ARPC2(1), ARPC3(1), ARPC4(1), PAK1(3), RAC1(1), WASL(2) 8748423 15 9 14 3 0 2 0 7 6 0 0.543 0.879 1.000 62 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(2), ACOX3(3), FADS2(2), PLA2G12B(1), PLA2G2D(1), PLA2G2F(1), PLA2G3(5), PLA2G4A(7), PLA2G5(1), PLA2G6(3) 12027388 26 17 26 4 6 4 4 9 3 0 0.0743 0.881 1.000 63 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(2), ENO1(2), GPI(2), HK1(4), PFKL(5), PGK1(3), PKLR(4), TPI1(1) 11011208 23 16 23 3 9 7 0 3 4 0 0.00812 0.888 1.000 64 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(7), LPO(5), MPO(4), PRDX1(1), TPO(10), TYR(5) 11481609 32 22 32 7 15 7 2 6 1 1 0.0438 0.898 1.000 65 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAD(2), ALAS1(2), ALAS2(1), CPO(3), FECH(2), GATA1(1), HBA2(1), HBB(1), HMBS(1), UROD(1), UROS(1) 9374306 16 12 16 3 4 3 2 5 2 0 0.164 0.900 1.000 66 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(12), CDC25A(1), CDC25B(1), CHEK1(6), MYT1(7), WEE1(2), YWHAH(2) 16361101 31 22 31 6 4 2 5 7 13 0 0.376 0.903 1.000 67 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(2), HLCS(3) 3666216 5 3 5 2 1 1 0 2 1 0 0.649 0.905 1.000 68 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(9), AGT(3), AGTR1(1), AGTR2(4), KNG1(4), NOS3(10), REN(7) 11814268 38 33 34 10 19 4 2 6 7 0 0.177 0.906 1.000 69 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 7 ACO1(6), ACO2(4), FH(1), SUCLA2(1) 8619144 12 8 12 0 3 3 2 3 1 0 0.0186 0.909 1.000 70 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(2), ALDH1A2(2), RDH5(1) 4624958 5 5 5 2 2 3 0 0 0 0 0.530 0.914 1.000 71 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNG(2), IFNGR1(1), IFNGR2(4), JAK1(3), JAK2(5), STAT1(4) 9717927 19 14 19 4 1 0 4 8 5 1 0.339 0.915 1.000 72 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 APEX1(2), CREBBP(13), DFFA(2), GZMA(1), GZMB(3), HMGB2(1), PRF1(3), SET(1) 12572264 26 18 26 4 9 2 4 5 6 0 0.0687 0.915 1.000 73 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 9 ACLY(4), ACO1(6), ACO2(4), ACSS1(1), ACSS2(4), FH(1), SUCLA2(1) 13833875 21 13 21 1 6 5 2 4 4 0 0.00375 0.919 1.000 74 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CCL3(1), CSF2(2), EPO(2), FLT3(8), IGF1(3), IL1A(1), IL3(2), IL6(2), IL9(1), KITLG(3), TGFB2(2), TGFB3(1) 9796105 28 21 28 9 4 4 5 10 5 0 0.433 0.919 1.000 75 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(4), ANKRD1(1), CYR61(1), DUSP14(1), EIF4E(2), HBEGF(1), IFNG(2), IFRD1(3), IL18(3), IL1A(1), IL1R1(4), NR4A3(1), WDR1(4) 12822925 28 24 28 8 5 4 3 6 10 0 0.481 0.922 1.000 76 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 13 AKT1(2), BCAR1(3), CDKN1B(4), ILK(1), ITGB1(3), MAPK1(4), MAPK3(2), PTK2(2), SHC1(1), SOS1(7) 17510271 29 21 29 3 6 2 6 6 8 1 0.0259 0.923 1.000 77 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 LHPP(1), MTMR1(6), MTMR2(3), MTMR6(1), NFS1(3), THTPA(2) 7608183 16 9 16 4 3 3 3 5 2 0 0.470 0.927 1.000 78 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(4), GAD1(3), HDC(5), TH(3), TPH1(5) 7173404 20 15 19 6 11 4 0 4 1 0 0.186 0.928 1.000 79 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(4), CYP2E1(2), NR1I3(1), PTGS1(3), PTGS2(3) 6332472 13 12 13 4 5 2 0 3 3 0 0.510 0.929 1.000 80 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 11 ASAH1(2), BFAR(1), CREB1(2), MAPK1(4), RAF1(2), SNX13(1), SRC(2), TERF2IP(1) 11548290 15 12 15 2 1 1 5 3 5 0 0.104 0.931 1.000 81 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 5 SP1(1), SP3(5), WT1(3) 6727322 9 7 9 2 2 2 1 2 2 0 0.396 0.933 1.000 82 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 7 GABRA2(3), GABRA3(4), GABRA4(10), GABRA5(4), PRKCE(1) 7150368 22 21 22 8 4 5 5 6 2 0 0.511 0.938 1.000 83 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(7), LPO(5), MPO(4), TPO(10) 9953096 26 19 26 7 14 7 1 3 1 0 0.109 0.944 1.000 84 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(1), COASY(2), DPYD(6), DPYS(5), ENPP1(5), ENPP3(2), PANK2(1), PANK4(3) 16531564 25 20 24 5 4 5 0 11 5 0 0.319 0.947 1.000 85 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(5), CKM(3), EIF4E(2), FBL(2), LDHA(1), LDHB(2), LDHC(1), NCL(3) 10599502 19 13 19 5 5 4 2 4 4 0 0.335 0.950 1.000 86 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(3), BAK1(2), BAX(1), BCL2(2), BCL2L11(1), CASP9(1), CES1(3) 13027583 13 11 13 1 5 1 1 3 3 0 0.111 0.952 1.000 87 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CTH(2), GOT1(2), GOT2(1), LDHA(1), LDHB(2), LDHC(1) 8119109 9 6 9 1 1 5 0 3 0 0 0.163 0.953 1.000 88 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT2(1), OXCT1(1) 4012273 2 2 2 0 0 1 0 1 0 0 0.592 0.954 1.000 89 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 10 ATM(12), CDC25A(1), CDC25B(1), CDK2(1), CDK4(1), CHEK1(6), MYT1(7), WEE1(2), YWHAH(2) 17836994 33 22 33 6 5 2 6 7 13 0 0.291 0.955 1.000 90 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 EGR1(5), MAP2K1(1), MAP2K2(1), MAPK1(4), MAPK3(2), NGFR(1), RAF1(2) 9801701 16 12 15 3 3 4 3 1 4 1 0.104 0.956 1.000 91 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD28(2), CD86(3), HLA-DRA(4), HLA-DRB1(1), IFNG(2), IFNGR1(1), IFNGR2(4), IL12B(4), IL12RB1(4), IL12RB2(4), IL18(3), IL18R1(4), IL4R(10) 15050265 46 38 45 13 15 2 5 16 8 0 0.202 0.957 1.000 92 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 GGT1(3), SHMT1(2) 6582337 5 5 5 1 1 2 2 0 0 0 0.330 0.958 1.000 93 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(1), AASDHPPT(1), AASS(1), KARS(2) 5609809 5 5 5 2 2 0 0 2 1 0 0.767 0.959 1.000 94 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(1), ACADM(2), ACADS(5), ECHS1(3), HADHA(3) 6418039 14 11 13 5 4 3 1 2 4 0 0.437 0.959 1.000 95 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 16 CSNK2A1(2), ELK1(5), FOS(2), MAP2K1(1), MAPK3(2), MAPK8(2), NGFR(1), PLCG1(12), RAF1(2), SHC1(1), SOS1(7) 18229725 37 30 35 7 5 9 5 10 7 1 0.0461 0.959 1.000 96 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 FUT2(2), FUT3(2), FUT5(6), FUT6(3), ST3GAL3(2) 6053179 15 12 15 5 9 1 0 4 1 0 0.451 0.962 1.000 97 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(4), CYP2A13(2), CYP2A7(1), NAT1(1), NAT2(3), XDH(11) 9455748 22 17 22 6 6 5 1 7 3 0 0.239 0.966 1.000 98 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 14 CD28(2), CD3D(1), CD3E(2), CD3G(1), CD86(3), CTLA4(1), HLA-DRA(4), HLA-DRB1(1), ICOS(1), ITK(1), LCK(1) 9252116 18 15 17 5 6 3 2 4 3 0 0.381 0.967 1.000 99 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(9), CD44(6), FCGR3A(1), IL1B(3), IL6R(1), SPN(1), TGFB2(2), TNF(1), TNFRSF1A(1), TNFRSF1B(3), TNFRSF8(4), TNFSF8(3) 15663743 35 27 34 8 13 7 3 5 7 0 0.0423 0.968 1.000 100 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(2), HK1(4), HK2(5), HK3(5), PGM1(1), PGM3(1), TGDS(2) 12133883 20 15 20 3 10 5 2 2 1 0 0.0328 0.970 1.000 101 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(1), COASY(2), DPYD(6), DPYS(5), ENPP1(5), ENPP3(2), ILVBL(5), PANK2(1), PANK4(3), VNN1(2) 20514867 32 25 31 6 6 6 1 13 6 0 0.176 0.972 1.000 102 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNAR1(2), IFNAR2(2), IFNB1(2), JAK1(3), STAT1(4), STAT2(2), TYK2(10) 12879901 25 18 25 5 7 1 1 10 5 1 0.193 0.973 1.000 103 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(2), CHAT(6), PCYT1A(2), PDHA1(6), PDHA2(7), SLC18A3(1) 8291589 24 19 22 9 7 8 2 3 4 0 0.283 0.973 1.000 104 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 CREB1(2), FOS(2), MAPK1(4), MAPK8(2), NFE2L2(1), PRKCA(6) 10546092 17 13 17 4 3 3 4 2 4 1 0.178 0.975 1.000 105 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 AKR1A1(3), ECHS1(3), EHHADH(2), HADHA(3), SDS(1) 5735428 12 9 12 7 3 3 2 1 3 0 0.746 0.979 1.000 106 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(5), GNAS(4), GNB1(1), PRKAR1A(2) 7851446 12 12 12 3 6 1 0 3 2 0 0.432 0.979 1.000 107 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(1), CYCS(2), GPD2(2), SDHA(4), SDHC(2), UQCRC1(4) 7844250 15 11 14 4 2 3 5 4 1 0 0.301 0.979 1.000 108 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(2), CYP11A1(7), CYP11B2(3), HSD11B1(2), HSD3B1(2), HSD3B2(1) 8188994 17 17 17 6 9 3 1 1 3 0 0.331 0.980 1.000 109 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT2(1), BDH1(1), BDH2(1), HMGCS1(2), HMGCS2(3), OXCT1(1), OXCT2(1) 8521839 10 5 10 1 2 3 0 4 1 0 0.188 0.981 1.000 110 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 13 AKT1(2), IGF1R(10), IRS1(8), MAP2K1(1), MAPK1(4), MAPK3(2), RAF1(2), SHC1(1), SOS1(7), YWHAH(2) 18023717 39 33 39 9 7 5 8 7 11 1 0.123 0.981 1.000 111 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(2), ENO2(2), ENO3(2), FARS2(3), GOT1(2), GOT2(1), PAH(4), TAT(3), YARS(1) 9843109 20 13 19 4 10 4 1 3 2 0 0.162 0.982 1.000 112 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 4 BGN(3), DCN(3), FMOD(1), KERA(4) 3487648 11 11 11 7 1 2 3 4 1 0 0.883 0.983 1.000 113 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 16 ACE(9), ACE2(7), AGT(3), AGTR1(1), AGTR2(4), ANPEP(5), CTSA(1), CTSG(5), ENPEP(10), LNPEP(3), MME(3), NLN(1), REN(7), THOP1(5) 24556204 64 50 60 13 21 9 7 14 13 0 0.0201 0.983 1.000 114 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 FOSB(2), GRIA2(2), PPP1R1B(1) 4492415 5 4 5 2 3 0 0 2 0 0 0.588 0.984 1.000 115 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 RAB27A(2), RAB3A(1), RAB9A(1) 5054138 4 3 4 1 2 1 0 1 0 0 0.573 0.984 1.000 116 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CCNB1(2), CDC25A(1), CDC25B(1), CSK(2), PRKCA(6), PTPRA(7), SRC(2) 10931833 21 14 21 4 9 4 3 3 1 1 0.0768 0.985 1.000 117 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 10 AKT1(2), NTRK1(3), PLCG1(12), PRKCA(6), SHC1(1), SOS1(7) 14001826 31 26 29 8 6 4 5 9 6 1 0.240 0.985 1.000 118 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ERBB4(5), NRG2(1), PRKCA(6), PSEN1(1) 10694245 13 9 13 2 4 1 2 4 1 1 0.203 0.986 1.000 119 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(15), MAP2(8), PPP1CA(1), PPP2CA(4), PRKACG(1), PRKAG1(1), PRKAR2B(1), PRKCE(1) 21589195 32 19 32 4 4 5 4 9 10 0 0.0973 0.986 1.000 120 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNB1(2), IFNG(2), IL10(1), IL12B(4), IL15(2), IL16(9), IL18(3), IL1A(1), IL3(2), IL5(1), IL6(2), IL9(1), TNF(1) 11770120 31 24 31 10 5 4 5 12 5 0 0.453 0.987 1.000 121 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 20 CEBPB(2), CSNK2A1(2), ELK1(5), FOS(2), IL6(2), IL6R(1), IL6ST(3), JAK1(3), JAK2(5), JAK3(5), MAP2K1(1), MAPK3(2), RAF1(2), SHC1(1), SOS1(7), SRF(3), STAT3(3) 26981649 49 37 49 7 10 10 3 15 10 1 0.00921 0.988 1.000 122 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(2), HK1(4), HK2(5), HK3(5), ISYNA1(2), PGM1(1), PGM3(1), TGDS(2) 13862482 22 16 22 3 10 6 2 3 1 0 0.0171 0.988 1.000 123 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(2), LDLR(3), MBTPS1(2), MBTPS2(3), SCAP(3), SREBF1(7), SREBF2(4) 14266597 24 18 24 6 5 5 3 8 3 0 0.233 0.989 1.000 124 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(2), GCK(2), GFPT1(5), GNPDA1(3), HEXA(1), HEXB(1), HK1(4), HK2(5), HK3(5), PGM3(1), RENBP(4), UAP1(2) 20112258 35 26 35 5 12 7 5 7 4 0 0.0175 0.989 1.000 125 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(1), LCMT1(3), LCMT2(2), METTL2B(3), METTL6(2), PCYT1A(2), PCYT1B(2), PRMT2(2), PRMT5(4), PRMT6(1), PRMT7(1), PRMT8(5), WBSCR22(2) 16725887 30 18 30 7 7 3 5 8 7 0 0.180 0.990 1.000 126 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(1), ATP6V0C(1), CAT(3), EPX(7), LPO(5), MPO(4), PRDX1(1), SHMT1(2), TPO(10) 14045390 34 20 34 9 16 9 2 4 2 1 0.0622 0.991 1.000 127 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 12 AKT1(2), CASP9(1), CHUK(1), GH1(2), GHR(4), NFKB1(2), NFKBIA(3), PPP2CA(4), RELA(1), YWHAH(2) 12253676 22 15 22 6 4 4 2 8 4 0 0.339 0.991 1.000 128 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 CBS(5), CTH(2), GGT1(3), MARS(7), MARS2(2), MAT1A(2), SCLY(3), SEPHS1(1) 14692219 25 16 25 4 5 8 3 6 3 0 0.0481 0.991 1.000 129 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(6), GALNT10(1), GALNT2(3), GALNT3(1), GALNT4(3), GALNT6(4), GALNT7(1), GALNT8(1), GALNT9(4), GCNT1(2), ST3GAL1(3), ST3GAL2(1), ST3GAL4(3), WBSCR17(11) 17122631 44 34 44 11 16 7 4 10 7 0 0.154 0.991 1.000 130 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(5), FHL5(3), FSHR(3), GNAS(4), XPO1(1) 11387888 16 15 16 4 5 3 3 3 2 0 0.390 0.991 1.000 131 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTR2(2), ACTR3(1), ARPC1A(1), ARPC1B(2), ARPC2(1), ARPC3(1), ARPC4(1), RAC1(1), WASF1(1), WASL(2) 9651747 13 7 13 3 0 2 1 7 3 0 0.525 0.991 1.000 132 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(1), CAT(3), EPX(7), LPO(5), MPO(4), MTHFR(7), SHMT1(2), TPO(10) 13795631 39 22 39 9 17 9 4 6 3 0 0.0384 0.991 1.000 133 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(2), F2(4), F2R(2), F5(13), F7(2), FGA(12), FGB(4), FGG(6), PROS1(3), SERPINC1(2) 19445524 50 45 49 14 15 7 10 12 6 0 0.150 0.991 1.000 134 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 CISH(1), IL6(2), IL6R(1), JAK1(3), JAK2(5), JAK3(5), PIAS3(3), PTPRU(3), REG1A(2), SRC(2), STAT3(3) 18144077 30 25 30 7 7 3 2 10 8 0 0.201 0.992 1.000 135 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(3), BIRC2(3), BIRC3(1), CASP10(1), CASP8(2), CASP9(1), DFFA(2), GZMB(3), PRF1(3), SCAP(3), SREBF1(7), SREBF2(4) 21732665 33 27 33 7 11 7 6 7 2 0 0.0849 0.992 1.000 136 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 AANAT(2), ACHE(2), CHAT(6), DBH(4), DDC(5), GAD1(3), GAD2(1), HDC(5), MAOA(3), PAH(4), SLC18A3(1), TH(3), TPH1(5) 17106931 44 32 43 13 21 9 2 10 2 0 0.0854 0.992 1.000 137 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 CARM1(1), DHRS2(2), DHRS3(1), DHRS7(1), DHRSX(1), LCMT1(3), LCMT2(2), METTL2B(3), METTL6(2), PRMT2(2), PRMT5(4), PRMT6(1), PRMT7(1), PRMT8(5), WBSCR22(2) 17834744 31 17 30 8 9 3 6 7 6 0 0.192 0.993 1.000 138 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(1), ACADM(2), ACADS(5), ACADVL(3), ACSL1(4), ACSL3(3), ACSL4(6), CPT1A(2), CPT2(2), EHHADH(2), HADHA(3), PECR(2), SCP2(1), SLC25A20(1) 19965837 37 25 36 9 6 8 3 8 12 0 0.136 0.993 1.000 139 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 19 AKT1(2), CCND1(4), CCNE1(2), CDK2(1), CDK4(1), CDKN1A(2), CDKN1B(4), E2F1(1), MAPK1(4), MAPK3(2), NFKB1(2), NFKBIA(3), PAK1(3), RAC1(1), RAF1(2), RELA(1), TFDP1(1) 17460162 36 26 35 7 8 3 7 6 11 1 0.0712 0.993 1.000 140 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 17 CSNK2A1(2), ELK1(5), FOS(2), IGF1(3), IGF1R(10), IRS1(8), MAP2K1(1), MAPK3(2), MAPK8(2), RAF1(2), RASA1(4), SHC1(1), SOS1(7), SRF(3) 23532436 52 43 52 13 10 10 8 11 12 1 0.106 0.993 1.000 141 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(2), PLCD1(4), PRKCA(6), TGM2(1) 5890694 13 10 13 5 5 0 1 6 0 1 0.585 0.993 1.000 142 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(17), CPT1A(2), LEPR(3), PRKAA1(3), PRKAA2(2), PRKAG1(1), PRKAG2(2) 17181944 30 18 30 4 10 3 1 9 7 0 0.0540 0.994 1.000 143 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 B3GALT1(2), B3GALT2(1), B3GALT5(2), B3GNT5(4), FUT2(2), FUT3(2), ST3GAL3(2), ST3GAL4(3) 8560651 18 13 18 6 9 0 1 6 2 0 0.471 0.994 1.000 144 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 CYP51A1(2), DHCR7(4), FDFT1(1), FDPS(3), HMGCS1(2), IDI1(2), LSS(1), MVD(4), MVK(1), NSDHL(2), SQLE(1) 15693512 23 15 23 6 8 1 5 6 3 0 0.344 0.995 1.000 145 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(4), APOBEC1(6), APOBEC2(1), APOBEC3B(2), APOBEC3C(1), APOBEC3F(4), APOBEC3G(2), APOBEC4(1) 8694663 21 20 21 7 8 3 2 6 2 0 0.445 0.995 1.000 146 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 18 ACO1(6), ACO2(4), DLD(3), FH(1), IDH3A(1), IDH3B(1), PC(4), PCK1(6), SDHA(4), SUCLA2(1), SUCLG1(2), SUCLG2(1) 22498020 34 27 33 5 8 9 5 9 3 0 0.0163 0.995 1.000 147 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD28(2), CD4(2), HLA-DRA(4), HLA-DRB1(1), IL10(1) 4722277 10 8 9 5 4 1 1 3 1 0 0.686 0.995 1.000 148 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(4), GLS2(1), GLUD1(4), GLUD2(4) 5397172 13 12 13 5 3 2 0 6 2 0 0.708 0.996 1.000 149 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD4(2), CD8A(1), CSF2(2), EPO(2), IL3(2), IL5(1), IL6(2), IL7(1), IL9(1) 7211957 14 12 14 7 3 2 1 5 3 0 0.776 0.996 1.000 150 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP1(1), ACP6(2), ACPP(4), ACPT(2), ALPI(2), ALPP(7), ALPPL2(6), CYP3A4(5), CYP3A43(1), CYP3A5(4), CYP3A7(2), DHRS2(2), DHRS3(1), DHRS7(1), DHRSX(1), PON1(4), PON3(1) 21370075 46 41 43 12 23 3 5 8 7 0 0.0918 0.996 1.000 151 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNB1(2), CCNH(2), CDC25A(1), CDC25B(1), CDK7(1), SHH(3), XPO1(1) 10326589 11 8 11 3 5 5 1 0 0 0 0.281 0.996 1.000 152 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(4), LCT(13), MPI(1), PGM1(1), PYGL(6), PYGM(2), TPI1(1) 15928923 28 19 28 7 8 6 3 5 6 0 0.101 0.996 1.000 153 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 18 APAF1(3), BAK1(2), BAX(1), BCL2(2), BIRC2(3), BIRC3(1), CASP8(2), CASP9(1), CYCS(2), DFFA(2), DIABLO(1) 15941883 20 16 20 5 4 4 3 6 3 0 0.365 0.997 1.000 154 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 20 ADCY1(5), AKT1(2), BAX(1), BCL2(2), CSF2RB(6), IGF1(3), IGF1R(10), IL3(2), IL3RA(4), KIT(9), KITLG(3), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), YWHAH(2) 21574168 54 42 53 12 17 3 9 13 12 0 0.0571 0.997 1.000 155 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 4 EGF(10), ERBB3(4), NRG1(5) 9086686 19 15 19 6 7 2 0 5 5 0 0.590 0.997 1.000 156 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(2), IFNB1(2), JAK1(3), PTPRU(3), REG1A(2), STAT1(4), STAT2(2), TYK2(10) 14845481 28 21 28 8 8 1 1 9 8 1 0.342 0.997 1.000 157 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(4), F2R(2), F2RL3(3), GNAI1(4), GNB1(1), ITGA1(4), ITGB1(3), MAP2K1(1), MAPK1(4), MAPK3(2), PLA2G4A(7), PLCB1(4), PRKCA(6), PTGS1(3), PTK2(2), RAF1(2), SRC(2), TBXAS1(2) 28959295 56 44 56 11 13 3 11 19 8 2 0.0460 0.997 1.000 158 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(1), CDKN1A(2), EPO(2), EPOR(1), GRIN1(2), JAK2(5), NFKB1(2), NFKBIA(3), RELA(1), SOD2(1) 15051554 20 14 20 5 5 2 1 8 4 0 0.338 0.998 1.000 159 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(13), EP300(6), ESR1(3), MAPK1(4), MAPK3(2), PELP1(2), SRC(2) 17522973 32 21 31 7 10 4 4 7 6 1 0.118 0.998 1.000 160 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(1), PSMA2(2), PSMA3(2), PSMA4(1), PSMA5(1), PSMB1(1), PSMB2(1), PSMB3(1), PSMB4(1), PSMB5(1), PSMB6(1), PSMB8(3) 10360020 16 9 16 3 4 5 3 3 1 0 0.184 0.998 1.000 161 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(4), FDFT1(1), FDPS(3), IDI1(2), LSS(1), MVD(4), MVK(1), NQO1(1), NQO2(1), SQLE(1) 13172587 19 12 19 5 6 1 5 4 3 0 0.343 0.998 1.000 162 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD28(2), CD3D(1), CD3E(2), CD3G(1), IFNG(2), TGFB2(2), TGFB3(1), TGFBR1(4), TGFBR2(5), TGFBR3(3), TOB1(1), TOB2(1) 12550187 25 18 24 6 6 7 4 5 3 0 0.119 0.998 1.000 163 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(2), ALDH1A2(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6) 9496019 20 14 20 7 10 3 2 3 2 0 0.359 0.998 1.000 164 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(2), ALDH1A2(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6) 9496019 20 14 20 7 10 3 2 3 2 0 0.359 0.998 1.000 165 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CDO1(1), CTH(2), GOT1(2), GOT2(1), LDHA(1), LDHAL6A(1), LDHAL6B(2), LDHB(2), LDHC(1), SDS(1), SULT1B1(9), SULT1C2(3) 14877425 26 18 26 7 3 8 2 10 3 0 0.350 0.998 1.000 166 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BAG4(1), BIRC3(1), CASP8(2), RIPK1(4), TNF(1), TNFRSF1A(1), TNFRSF1B(3), TRADD(1), TRAF2(2) 9991431 16 15 16 6 5 3 2 3 3 0 0.557 0.998 1.000 167 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 BPNT1(1), SULT1A2(1), SULT2A1(2), SUOX(2) 7241287 6 3 6 5 0 1 0 3 2 0 0.970 0.999 1.000 168 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 CISH(1), IFNG(2), IFNGR1(1), JAK1(3), JAK2(5), PTPRU(3), REG1A(2), STAT1(4) 13576306 21 15 21 7 3 1 2 7 7 1 0.502 0.999 1.000 169 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(6), ACO2(4), AFMID(1), HAO1(4), HAO2(2), HYI(3), MTHFD1(3), MTHFD1L(1) 15880457 24 16 24 5 4 5 4 6 5 0 0.195 0.999 1.000 170 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 ALAD(2), BLVRA(2), CP(7), EPRS(5), FECH(2), GUSB(3), HCCS(5), HMBS(1), HMOX1(1), PPOX(2), UGT1A1(5), UGT1A10(2), UGT1A3(3), UGT1A4(1), UGT1A5(3), UGT1A6(4), UGT1A7(3), UGT1A9(2), UGT2B15(3), UGT2B4(9), UROD(1), UROS(1) 32493976 67 52 66 15 18 9 13 22 5 0 0.0372 0.999 1.000 171 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(3), ARHGAP5(5), ARHGDIB(1), CASP1(6), CASP10(1), CASP8(2), CASP9(1), CYCS(2), GZMB(3), PRF1(3) 15283399 27 22 26 9 6 6 3 10 2 0 0.476 0.999 1.000 172 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 15 ADRB2(1), AKT1(2), ANXA1(2), CALM1(1), CALM3(1), GNAS(4), GNB1(1), NFKB1(2), NOS3(10), NPPA(2), NR3C1(3), RELA(1), SYT1(2) 16870011 32 25 32 9 14 3 4 7 4 0 0.327 0.999 1.000 173 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 23 ABL1(6), ATM(12), ATR(10), CCNA1(3), CCND1(4), CCNE1(2), CDC25A(1), CDK2(1), CDK4(1), CDKN1A(2), CDKN1B(4), CDKN2A(6), CDKN2B(2), DHFR(1), E2F1(1), GSK3B(1), SKP2(3), TFDP1(1), TGFB2(2), TGFB3(1) 32720599 64 43 63 9 11 8 11 19 15 0 0.00648 0.999 1.000 174 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 19 F10(2), F12(1), F13B(5), F2(4), F5(13), F7(2), F8(24), FGA(12), FGB(4), FGG(6), LPA(11), PLAT(3), PLG(6), SERPINB2(3), SERPINE1(4), SERPINF2(1), VWF(14) 40774477 115 81 114 26 32 21 15 29 18 0 0.00369 0.999 1.000 175 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH7A1(2), MIOX(1), UGDH(1) 10137379 20 12 20 5 11 2 2 3 2 0 0.184 0.999 1.000 176 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 ST3GAL1(3), ST3GAL2(1), ST3GAL4(3), ST6GALNAC4(1), ST8SIA1(2) 6701819 10 10 10 5 4 0 1 3 2 0 0.839 0.999 1.000 177 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 4 DLL1(1), FURIN(1), PSEN1(1) 6197024 3 3 3 2 1 0 0 1 1 0 0.948 0.999 1.000 178 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(3), ECHS1(3), HADHA(3), HSD17B4(3), MECR(2), PPT2(2) 10070357 16 12 16 6 2 3 2 4 5 0 0.641 0.999 1.000 179 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(5), ADRB2(1), CFTR(6), GNAS(4), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), SLC9A3R1(1) 15569044 22 20 22 5 11 3 1 4 3 0 0.224 0.999 1.000 180 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(1), AASDH(3), AASDHPPT(1), AASS(1), KARS(2) 8268664 8 7 8 4 2 0 1 3 2 0 0.880 0.999 1.000 181 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(6), ACO2(4), HAO1(4), HAO2(2), HYI(3), MTHFD1(3), MTHFD1L(1) 15162449 23 15 23 5 4 5 4 6 4 0 0.199 0.999 1.000 182 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 16 B3GAT1(1), CHPF(1), CHST11(3), CHST13(3), CHST3(3), CHSY1(4), DSE(6), UST(1), XYLT1(3), XYLT2(3) 16680196 28 23 28 6 10 4 2 8 4 0 0.0818 0.999 1.000 183 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(5), ADRB2(1), GNAS(4), PLCE1(10), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), RAP2B(4) 17565426 29 24 29 7 13 6 2 3 5 0 0.163 0.999 1.000 184 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(1), F13A1(5), F2(4), F2R(2), FGA(12), FGB(4), FGG(6), PLAT(3), PLG(6), SERPINB2(3), SERPINE1(4) 15900021 50 43 49 16 15 9 7 13 6 0 0.284 0.999 1.000 185 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 MMP9(4), RECK(4), TIMP1(1), TIMP3(2), TIMP4(2) 8936183 13 10 13 5 5 2 1 3 2 0 0.575 0.999 1.000 186 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 12 AKT1(2), BCL2(2), IGF1R(10), POLR2A(9), PPP2CA(4), PRKCA(6), TEP1(12), TERF1(1), TERT(5), TNKS(2), XRCC5(4) 27288018 57 41 57 13 20 5 9 14 8 1 0.0388 0.999 1.000 187 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 FUT2(2), GCNT2(1), ST8SIA1(2) 7299839 5 4 5 6 2 0 0 1 2 0 0.998 0.999 1.000 188 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(6), FOS(2), IL3(2), IL3RA(4), JAK2(5), MAP2K1(1), MAPK3(2), PTPN6(1), RAF1(2), SHC1(1), SOS1(7), STAT5A(1), STAT5B(2) 20999106 36 27 35 9 10 3 5 11 6 1 0.221 0.999 1.000 189 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 28 ATG12(2), ATG5(4), ATG7(3), IFNA10(2), IFNA5(1), IFNA6(1), IFNA7(1), IFNA8(1), IFNG(2), INS(1), PIK3C3(2), PIK3R4(3), PRKAA1(3), PRKAA2(2), ULK1(2), ULK2(7) 24599447 37 20 36 6 7 4 7 10 9 0 0.0341 0.999 1.000 190 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 12 ABL1(6), CDKN2A(6), E2F1(1), MDM2(5), POLR1A(7), POLR1B(3), RAC1(1), TBX2(1) 16501409 30 18 29 8 7 3 4 7 9 0 0.185 0.999 1.000 191 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT2(1), ACYP1(1), ECHS1(3), EHHADH(2), GCDH(1), HADHA(3), SDS(1) 9252577 12 10 12 9 2 4 1 2 3 0 0.926 0.999 1.000 192 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(2), AKR1D1(1), CYP11A1(7), CYP11B1(2), CYP11B2(3), CYP21A2(1), HSD11B1(2), HSD3B1(2), HSD3B2(1) 11007722 21 20 21 7 9 3 2 3 4 0 0.364 0.999 1.000 193 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(2), AKR1D1(1), CYP11A1(7), CYP11B1(2), CYP11B2(3), CYP21A2(1), HSD11B1(2), HSD3B1(2), HSD3B2(1) 11007722 21 20 21 7 9 3 2 3 4 0 0.364 0.999 1.000 194 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA10(4), NDUFA4(1), NDUFB5(1), NDUFS1(2), NDUFS2(1), NDUFV1(2), NDUFV2(1) 8275691 12 7 12 5 0 1 2 5 4 0 0.818 1.000 1.000 195 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 19 ARFIP2(2), CFL1(1), LIMK1(4), MAP3K1(9), MYL2(2), MYLK(7), NCF2(6), PAK1(3), PLD1(8), PPP1R12B(1), RAC1(1), RALBP1(3), RPS6KB1(2), TRIO(7), VAV1(9), WASF1(1) 34326266 66 47 63 12 17 9 12 15 13 0 0.00614 1.000 1.000 196 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(2), GNAS(4), GNB1(1), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), PRKCA(6) 11433929 18 15 18 5 8 0 1 6 2 1 0.577 1.000 1.000 197 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 6 ATM(12), ATR(10), CHEK1(6), CHEK2(3), YWHAH(2) 18038138 33 22 33 7 5 6 7 8 7 0 0.261 1.000 1.000 198 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 AKR1A1(3), ECHS1(3), EHHADH(2), HADHA(3), HSD17B4(3), SIRT1(1), SIRT2(1), SIRT5(3), SIRT7(1), VNN2(1) 14062823 21 17 21 9 5 3 2 5 6 0 0.715 1.000 1.000 199 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 19 AKT1(2), APAF1(3), ATM(12), BAX(1), BCL2(2), CASP9(1), CYCS(2), PRKCA(6), PTK2(2), PXN(1), STAT1(4), TLN1(5) 31578944 41 29 41 8 7 2 6 14 10 2 0.151 1.000 1.000 200 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 NFKB1(2), NFKBIA(3), PLCB1(4), PRKCA(6), RELA(1) 9782185 16 13 16 8 5 0 1 7 2 1 0.855 1.000 1.000 201 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CCL2(1), IL1B(3), MST1R(4), TNF(1) 7789225 9 7 9 4 2 3 0 2 2 0 0.642 1.000 1.000 202 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1A(2), ADRA1B(2), ADRA2A(1), ADRA2C(3), ADRB2(1), CHRM1(3), CHRM2(3), CHRM3(4), CHRM4(3), CHRM5(4), DRD1(1), DRD2(1), DRD3(3), DRD5(10), HRH1(3), HRH2(3), HTR1A(2), HTR1B(2), HTR1D(3), HTR1E(3), HTR1F(3), HTR2A(2), HTR2B(2), HTR2C(4), HTR4(2), HTR5A(8), HTR6(1), HTR7(4) 30495966 83 64 81 20 46 12 6 12 7 0 0.000409 1.000 1.000 203 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT1(2), AGPAT2(2), AGPAT3(1), AGPAT6(2), AGPS(3), ENPP2(7), ENPP6(2), PAFAH1B1(4), PAFAH1B3(1), PAFAH2(2), PLA2G12B(1), PLA2G2D(1), PLA2G2F(1), PLA2G3(5), PLA2G4A(7), PLA2G5(1), PLA2G6(3), PLD1(8), PPAP2A(2), PPAP2C(1) 27531374 56 38 55 14 17 8 8 18 5 0 0.106 1.000 1.000 204 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 CREB1(2), PTK2B(5), SHC1(1), SOS1(7), SRC(2) 10484569 17 15 17 5 3 2 1 6 5 0 0.411 1.000 1.000 205 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 12 CREB1(2), FOS(2), MAPK3(2), POLR2A(9), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1) 14440647 20 17 20 6 6 2 1 6 4 1 0.452 1.000 1.000 206 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(3), BMPR1A(1), BMPR1B(1), BMPR2(1) 7460567 6 5 6 5 2 0 2 1 1 0 0.979 1.000 1.000 207 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 AOC2(1), CES1(3) 7173782 4 4 4 2 3 1 0 0 0 0 0.632 1.000 1.000 208 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(1), PSMA2(2), PSMA3(2), PSMA4(1), PSMA5(1), PSMB1(1), PSMB2(1), PSMB3(1), PSMB4(1), PSMB5(1), PSMB6(1), PSMC2(1), PSMC3(2), PSMD1(1), PSMD11(2), PSMD2(3) 18984499 22 12 22 4 3 9 3 4 3 0 0.129 1.000 1.000 209 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 16 DNAJA3(3), IFNG(2), IFNGR1(1), IFNGR2(4), IKBKB(2), JAK2(5), NFKB1(2), NFKBIA(3), RELA(1), TNF(1), TNFRSF1A(1), TNFRSF1B(3), USH1C(2), WT1(3) 18575106 33 23 33 9 6 3 5 12 7 0 0.262 1.000 1.000 210 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 23 CSNK2A1(2), ELK1(5), FOS(2), JAK1(3), MAP2K1(1), MAP3K1(9), MAPK3(2), MAPK8(2), PDGFA(1), PLCG1(12), PRKCA(6), RAF1(2), RASA1(4), SHC1(1), SOS1(7), SRF(3), STAT1(4), STAT3(3), STAT5A(1) 34343615 70 54 66 15 15 16 8 17 11 3 0.0205 1.000 1.000 211 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 C1GALT1(1), GALNT1(6), GALNT10(1), GALNT11(3), GALNT12(3), GALNT13(4), GALNT14(7), GALNT2(3), GALNT3(1), GALNT4(3), GALNT5(5), GALNT6(4), GALNT7(1), GALNT8(1), GALNT9(4), GALNTL5(1), GCNT1(2), GCNT3(2), GCNT4(3), OGT(9), ST3GAL1(3), ST3GAL2(1), ST6GALNAC1(2), WBSCR17(11) 38364099 81 60 80 19 28 14 5 21 13 0 0.0554 1.000 1.000 212 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(3), ATP6V0A4(3), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(1), ATP6V1G1(1), ATP6V1G3(2), ATP6V1H(1), SHMT1(2) 17885914 24 20 24 7 7 7 4 5 0 1 0.242 1.000 1.000 213 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(3), ATP6V0A4(3), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(1), ATP6V1G1(1), ATP6V1G3(2), ATP6V1H(1), SHMT1(2) 17885914 24 20 24 7 7 7 4 5 0 1 0.242 1.000 1.000 214 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(3), ATP6V0A4(3), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(1), ATP6V1G1(1), ATP6V1G3(2), ATP6V1H(1), SHMT1(2) 17885914 24 20 24 7 7 7 4 5 0 1 0.242 1.000 1.000 215 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(3), FARSA(1), GOT1(2), GOT2(1), PAH(4), TAT(3), YARS(1), YARS2(1) 10343210 16 13 15 5 6 5 1 3 1 0 0.431 1.000 1.000 216 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(1), ACACA(17), ACACB(18), ACADM(2), ACAT2(1), ACSS1(1), ACSS2(4), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH6A1(5), ALDH7A1(2), ECHS1(3), EHHADH(2), HADHA(3), HIBCH(2), LDHA(1), LDHAL6A(1), LDHAL6B(2), LDHB(2), LDHC(1), MLYCD(4), MUT(2), PCCA(3), PCCB(4), SUCLA2(1), SUCLG1(2), SUCLG2(1) 47091000 101 65 101 21 33 23 8 24 13 0 0.00410 1.000 1.000 217 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 F13B(5), HSD17B3(1), HSD17B4(3), HSD17B7(2), HSD3B1(2), HSD3B2(1) 9608865 14 14 13 7 2 5 3 2 2 0 0.696 1.000 1.000 218 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 20 CSNK2A1(2), FOS(2), JAK2(5), MAP2K1(1), MAPK3(2), MPL(5), PLCG1(12), PRKCA(6), RAF1(2), RASA1(4), SHC1(1), SOS1(7), STAT1(4), STAT3(3), STAT5A(1), STAT5B(2), THPO(2) 31097442 61 46 59 12 15 9 7 18 9 3 0.0267 1.000 1.000 219 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 19 AKT1(2), CASP9(1), CHUK(1), ELK1(5), H2AFX(1), MAP2K1(1), MAPK3(2), NFKB1(2), RAC1(1), RAF1(2), RALA(2), RALBP1(3), RALGDS(4), RELA(1) 18225290 28 18 28 9 5 2 4 6 10 1 0.409 1.000 1.000 220 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 11 CREBBP(13), DAXX(5), PAX3(4), PML(3), SIRT1(1), SP100(6), TNF(1), TNFRSF1A(1), TNFRSF1B(3) 19605087 37 24 37 8 8 6 4 12 7 0 0.133 1.000 1.000 221 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 CALM1(1), CALM3(1), CDKN1A(2), MARCKS(1), NFATC1(2), NFATC2(7), NFATC3(2), NFATC4(5), PLCG1(12), PPP3CA(1), PPP3CB(1), PPP3CC(1), PRKCA(6), SP1(1), SP3(5), SYT1(2) 24908800 50 37 48 13 13 8 7 13 8 1 0.108 1.000 1.000 222 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 21 COL4A1(4), COL4A2(7), COL4A3(1), COL4A4(11), COL4A5(11), COL4A6(9), F10(2), F12(1), F2(4), F2R(2), F5(13), F8(24), FGA(12), FGB(4), FGG(6), KLKB1(7), PROS1(3), SERPINC1(2), SERPING1(4) 51751552 127 96 125 30 30 27 20 30 19 1 0.00395 1.000 1.000 223 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 EPHA4(8), EPHB1(4), FYN(2), ITGA1(4), ITGB1(3), L1CAM(12), LYN(2), SELP(4) 18735937 39 27 39 12 13 7 8 10 1 0 0.257 1.000 1.000 224 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 20 ATM(12), ATR(10), BRCA1(6), BRCA2(13), CHEK1(6), CHEK2(3), FANCA(4), FANCC(1), FANCD2(10), FANCE(2), HUS1(1), MRE11A(3), RAD1(2), RAD17(2), RAD50(6), RAD9A(2), TREX1(2) 51437187 85 56 84 15 18 19 17 20 11 0 0.00692 1.000 1.000 225 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(13), EP300(6), LPL(2), NCOA1(3), NCOA2(5), PPARG(3), RXRA(4) 21938268 36 27 35 10 9 7 2 11 7 0 0.307 1.000 1.000 226 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(2), ELK1(5), EPO(2), EPOR(1), FOS(2), JAK2(5), MAP2K1(1), MAPK3(2), MAPK8(2), PLCG1(12), PTPN6(1), RAF1(2), SHC1(1), SOS1(7), STAT5A(1), STAT5B(2) 25561941 48 37 46 12 7 9 7 15 9 1 0.114 1.000 1.000 227 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(15), ABCB11(3), ABCB4(12), ABCC1(6), ABCC3(6) 17031636 42 31 41 14 11 7 4 12 7 1 0.348 1.000 1.000 228 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(2), IL4R(10), IRS1(8), JAK1(3), JAK3(5), RPS6KB1(2), SHC1(1), STAT6(5) 17620687 36 31 36 10 9 4 2 11 10 0 0.302 1.000 1.000 229 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 11 ACE2(7), AGT(3), AGTR1(1), AGTR2(4), COL4A1(4), COL4A2(7), COL4A3(1), COL4A4(11), COL4A5(11), COL4A6(9), REN(7) 29448834 65 47 62 21 17 18 7 12 10 1 0.210 1.000 1.000 230 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 CHIA(2), CMAS(2), CYB5R1(1), GFPT1(5), GFPT2(3), GNPDA1(3), GNPNAT1(2), HEXA(1), HEXB(1), HK1(4), HK2(5), HK3(5), LHPP(1), MTMR1(6), MTMR2(3), MTMR6(1), NANS(1), NPL(1), PGM3(1), RENBP(4), UAP1(2) 34057697 54 41 54 12 15 9 10 12 8 0 0.0773 1.000 1.000 231 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(3), ARHGDIB(1), BIRC2(3), BIRC3(1), CASP1(6), CASP10(1), CASP2(1), CASP4(1), CASP8(2), CASP9(1), CYCS(2), DFFA(2), GZMB(3), LMNA(2), LMNB2(3), PRF1(3) 22953722 35 25 35 9 9 8 6 9 3 0 0.197 1.000 1.000 232 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(2), DAG1(3) 7238664 5 5 5 3 1 1 3 0 0 0 0.779 1.000 1.000 233 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(9), BAIAP2(3), CASP1(6), CASP8(2), GAPDH(1), INS(1), INSR(6), ITCH(1), MAGI1(6), MAGI2(6), RERE(11), WWP1(3), WWP2(2) 28480069 57 39 56 15 16 14 5 15 7 0 0.166 1.000 1.000 234 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(9), BST1(1), CD38(1), ENPP1(5), ENPP3(2), NADK(1), NADSYN1(5), NMNAT1(1), NMNAT3(1), NNMT(1), NNT(6), NT5C(3), NT5C1A(1), NT5C1B(7), NT5C2(1), NT5E(3), NT5M(1), NUDT12(1) 25558214 50 36 48 15 12 14 8 11 5 0 0.160 1.000 1.000 235 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 23 CSNK2A1(2), EGF(10), ELK1(5), FOS(2), JAK1(3), MAP2K1(1), MAP3K1(9), MAPK3(2), MAPK8(2), PLCG1(12), PRKCA(6), RAF1(2), RASA1(4), SHC1(1), SOS1(7), SRF(3), STAT1(4), STAT3(3), STAT5A(1) 36914684 79 61 75 20 18 17 8 21 12 3 0.0725 1.000 1.000 236 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 9 DFFA(2), GZMB(3), HMGB2(1), TOP2A(4), TOP2B(3) 10729155 13 8 13 5 5 1 2 3 2 0 0.696 1.000 1.000 237 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 HS3ST1(3), HS3ST3A1(3), XYLT1(3), XYLT2(3) 7840481 12 12 12 5 6 2 3 1 0 0 0.521 1.000 1.000 238 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 HS3ST1(3), HS3ST3A1(3), XYLT1(3), XYLT2(3) 7840481 12 12 12 5 6 2 3 1 0 0 0.521 1.000 1.000 239 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 8 CHUK(1), DNAJC3(2), EIF2S2(2), NFKB1(2), NFKBIA(3), RELA(1) 10674982 11 8 11 5 2 2 1 4 2 0 0.731 1.000 1.000 240 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(5), CD3D(1), CD3E(2), CD3G(1), CD4(2), CREBBP(13), CSK(2), GNAS(4), GNB1(1), HLA-DRA(4), HLA-DRB1(1), LCK(1), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), PTPRC(9), ZAP70(8) 27349378 59 45 59 13 21 9 4 16 9 0 0.0727 1.000 1.000 241 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(5), CD3D(1), CD3E(2), CD3G(1), CD4(2), CREBBP(13), CSK(2), GNAS(4), GNB1(1), HLA-DRA(4), HLA-DRB1(1), LCK(1), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), PTPRC(9), ZAP70(8) 27349378 59 45 59 13 21 9 4 16 9 0 0.0727 1.000 1.000 242 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ARG2(2), ASL(2), CKB(1), CKM(3), CKMT1A(2), CKMT1B(4), CKMT2(1), CPS1(8), GAMT(1), GATM(2), GLUD1(4), NAGS(1), OAT(1), ODC1(3), OTC(2), SMS(1) 20822996 38 27 38 10 9 6 4 11 8 0 0.292 1.000 1.000 243 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(2), CAMK1G(1), HDAC9(3), MEF2A(4), MEF2B(1), MEF2D(1), MYOD1(1), YWHAH(2) 9249506 15 11 15 6 2 5 2 2 4 0 0.628 1.000 1.000 244 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6AP1(3), ATP6V0A4(3), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(1), ATP6V1G1(1), ATP6V1G3(2), ATP6V1H(1), FDXR(1), SHMT1(2) 19029470 25 20 25 7 8 7 4 5 0 1 0.210 1.000 1.000 245 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(9), PRKACG(1), PRKAG1(1), PRKAR2B(1) 11980933 12 8 12 5 2 0 1 6 3 0 0.828 1.000 1.000 246 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 CLOCK(3), CRY1(3), CSNK1E(1), PER1(6) 10144550 13 9 12 6 3 3 1 4 2 0 0.826 1.000 1.000 247 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(1), IARS(4), LARS(4), PDHA1(6), PDHA2(7), PDHB(1) 11898855 23 18 21 9 3 8 2 5 5 0 0.626 1.000 1.000 248 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 GLB1(2), GUSB(3), HEXA(1), HEXB(1), HGSNAT(3), HPSE(5), HPSE2(5), HYAL1(3), HYAL2(1), IDS(2), LCT(13), NAGLU(3), SPAM1(7) 24383102 49 35 47 13 22 5 6 10 6 0 0.145 1.000 1.000 249 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(4), CAPN1(2), CAPNS1(2), CAPNS2(1), CSNK1A1(2), CSNK1D(2), GSK3B(1), PPP2CA(4) 11056196 18 10 18 7 4 3 4 6 1 0 0.621 1.000 1.000 250 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 19 ADCY1(5), AKT1(2), ASAH1(2), GNAI1(4), GNB1(1), ITGAV(3), ITGB3(3), MAPK1(4), MAPK3(2), PDGFA(1), PLCB1(4), PRKCA(6), PTK2(2), RAC1(1), SMPD1(1), SMPD2(1), SRC(2) 25453829 44 33 44 12 12 4 9 8 9 2 0.132 1.000 1.000 251 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 ATM(12), BMPR1B(1), CCND2(2), CDK4(1), CDKN1B(4), CEBPB(2), DMC1(2), EGR1(5), ESR2(6), FSHR(3), GJA4(1), LHCGR(2), MLH1(4), MSH5(4), NCOR1(9), NR5A1(1), NRIP1(4), PGR(9), PRLR(2), SMPD1(1), VDR(2), ZP2(6) 41666246 83 57 82 21 14 18 10 24 16 1 0.192 1.000 1.000 252 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(3), ASNS(4), CA1(1), CA12(3), CA14(1), CA2(1), CA5A(1), CA9(1), CPS1(8), CTH(2), GLS(4), GLS2(1), GLUD1(4), GLUL(2), HAL(3) 22558785 39 32 39 10 12 7 3 10 7 0 0.189 1.000 1.000 253 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 BPNT1(1), CHST11(3), CHST13(3), SULT1A1(1), SULT1A2(1), SULT2A1(2), SULT2B1(3), SUOX(2) 10919578 16 12 16 6 3 2 0 8 3 0 0.691 1.000 1.000 254 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(3), EIF2AK4(4), EIF2S2(2), EIF2S3(3), GSK3B(1), PPP1CA(1) 13718454 14 12 14 8 1 2 4 4 3 0 0.898 1.000 1.000 255 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CD36(5), FOS(2), FYN(2), THBS1(6) 8769079 15 12 15 7 5 5 3 1 1 0 0.529 1.000 1.000 256 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CCR5(1), CD2(1), CD3D(1), CD3E(2), CD3G(1), CD4(2), IFNG(2), IL12B(4), IL12RB1(4), IL12RB2(4), JAK2(5), STAT4(4), TYK2(10) 17509149 41 26 41 10 19 2 6 9 5 0 0.140 1.000 1.000 257 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(5), GNAS(4), GNB1(1), PPP2CA(4), PRKAA1(3), PRKAA2(2), PRKACG(1), PRKAG1(1), PRKAG2(2), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1) 18254383 27 18 27 6 11 2 0 10 4 0 0.297 1.000 1.000 258 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(3), ACTN2(6), BCAR1(3), CSK(2), CTNNA1(2), CTNNA2(5), CTNNB1(3), PTK2(2), PXN(1), SRC(2), VCL(1) 22782479 30 20 30 7 11 5 3 6 5 0 0.159 1.000 1.000 259 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(3), ALOX15(2), ALOX5(2), CYP1A2(4), CYP2C18(4), CYP2C19(5), CYP2C8(4), CYP2C9(3), CYP2E1(2), CYP3A4(5), CYP3A43(1), CYP3A5(4), CYP3A7(2), HSD3B7(1), PLA2G12B(1), PLA2G2D(1), PLA2G2F(1), PLA2G3(5), PLA2G4A(7), PLA2G5(1), PLA2G6(3) 28335289 61 52 61 16 20 8 7 16 10 0 0.126 1.000 1.000 260 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CCR5(1), CD3D(1), CD3E(2), CD3G(1), ETV5(3), IFNG(2), IL12B(4), IL12RB1(4), IL12RB2(4), IL18(3), IL18R1(4), JAK2(5), MAPK8(2), STAT4(4), TYK2(10) 22197772 50 34 50 15 19 3 10 13 5 0 0.278 1.000 1.000 261 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 27 ELK1(5), GNAS(4), GNB1(1), IGF1R(10), ITGB1(3), MAP2K1(1), MAP2K2(1), MAPK1(4), MAPK3(2), MKNK1(2), NGFR(1), PPP2CA(4), PTPRR(6), RAF1(2), RPS6KA1(5), RPS6KA5(2), SHC1(1), SOS1(7), SRC(2), STAT3(3) 33557665 66 51 66 16 18 8 9 17 13 1 0.0896 1.000 1.000 262 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 ALDOA(1), CTSD(1), ESR1(3), GREB1(7), MTA1(1), MTA3(3), PDZK1(1), TUBA8(2) 13013752 19 12 19 8 8 3 1 4 3 0 0.537 1.000 1.000 263 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 18 B2M(1), HLA-A(1), IL18(3), ITGB1(3), KLRC1(3), KLRC2(1), KLRC3(4), KLRC4(1), KLRD1(1), LAT(2), MAP2K1(1), MAPK3(2), PAK1(3), PTK2B(5), PTPN6(1), RAC1(1), VAV1(9) 17642014 42 28 41 13 10 4 6 10 11 1 0.386 1.000 1.000 264 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ADCY1(5), CCNB1(2), GNAI1(4), GNAS(4), GNB1(1), MAPK1(4), MAPK3(2), MYT1(7), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), RPS6KA1(5), SRC(2) 24422777 41 36 41 10 12 2 5 7 14 1 0.245 1.000 1.000 265 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 CARM1(1), CBS(5), CTH(2), GGT1(3), LCMT1(3), LCMT2(2), MARS(7), MARS2(2), MAT1A(2), METTL2B(3), METTL6(2), PRMT2(2), PRMT5(4), PRMT6(1), PRMT7(1), PRMT8(5), SCLY(3), SEPHS1(1), WBSCR22(2) 29619040 51 30 51 10 10 11 8 13 9 0 0.0252 1.000 1.000 266 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(17), ACACB(18), FASN(3), MCAT(3), OXSM(3) 18824614 44 35 44 14 15 7 5 10 7 0 0.253 1.000 1.000 267 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(1), ALDH4A1(2), ALDH5A1(2), CAD(8), CPS1(8), EPRS(5), GAD1(3), GAD2(1), GCLC(1), GFPT1(5), GLS(4), GLS2(1), GLUD1(4), GLUL(2), GOT1(2), GOT2(1), GSS(2), NADSYN1(5), PPAT(2), QARS(5) 39363159 64 44 64 9 13 11 13 18 9 0 0.00288 1.000 1.000 268 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 AKR1B10(3), DHRS2(2), DHRS3(1), DHRS7(1), DHRSX(1), HSD3B7(1), PON1(4), PON3(1) 10665323 14 10 13 9 6 0 1 5 2 0 0.961 1.000 1.000 269 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(3), CALM1(1), CALM3(1), CRKL(2), MAP2K1(1), MAP2K2(1), MAP2K3(6), MAP3K1(9), MAPK1(4), MAPK3(2), MAPK8(2), PAK1(3), PLCG1(12), PRKCA(6), PTK2B(5), RAC1(1), RAF1(2), SHC1(1), SOS1(7), SRC(2), SYT1(2) 33878160 73 55 68 16 18 15 12 11 15 2 0.0107 1.000 1.000 270 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(17), ACAT2(1), ACYP1(1), ADH5(1), ALDH1A1(2), ALDH1A2(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), DLD(3), HAGH(1), LDHA(1), LDHB(2), LDHC(1), LDHD(1), ME1(2), ME2(2), ME3(1), PC(4), PCK1(6), PDHA1(6), PDHA2(7), PDHB(1), PKLR(4) 43921933 82 62 80 21 28 20 5 18 11 0 0.0365 1.000 1.000 271 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 18 CSNK2A1(2), ELK1(5), FOS(2), INS(1), INSR(6), IRS1(8), MAP2K1(1), MAPK3(2), MAPK8(2), RAF1(2), RASA1(4), SHC1(1), SLC2A4(2), SOS1(7), SRF(3) 24369384 48 36 48 14 12 12 4 9 10 1 0.197 1.000 1.000 272 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 APAF1(3), BCL2(2), CASP9(1), CYCS(2), DAXX(5), FAS(1), FASLG(1), IL1A(1), MAPKAPK2(2), MAPKAPK3(2), TNF(1) 13468717 21 14 21 8 1 6 4 7 3 0 0.692 1.000 1.000 273 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 6 EEA1(3), EGF(10), HGS(3), TF(2), TFRC(2) 12107464 20 15 20 9 6 3 2 7 2 0 0.781 1.000 1.000 274 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 ATF2(2), BCR(3), BLNK(2), ELK1(5), FOS(2), LYN(2), MAP2K1(1), MAP3K1(9), MAPK1(4), MAPK3(2), MAPK8IP3(6), PAPPA(6), RAC1(1), RPS6KA1(5), RPS6KA3(4), SHC1(1), SOS1(7), VAV1(9), VAV2(4), VAV3(3) 38113630 78 54 76 19 16 16 8 22 15 1 0.0428 1.000 1.000 275 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM1(1), CALM3(1), CAMK1(2), CAMK1G(1), CAMK2A(3), CAMK2D(1), CAMK2G(2), CAMK4(3), CAMKK1(2), CAMKK2(2), CREB1(2), SYT1(2) 13760218 22 14 22 8 6 5 4 1 6 0 0.425 1.000 1.000 276 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 14 AKT1(2), CDKN1A(2), ELK1(5), MAP2K1(1), MAP2K2(1), NGFR(1), NTRK1(3), PIK3CD(3), SHC1(1), SOS1(7) 16671442 26 19 26 9 6 4 2 7 7 0 0.438 1.000 1.000 277 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 25 AKT1(2), CISH(1), IARS(4), IL13RA1(3), IL4R(10), INPP5D(5), JAK1(3), JAK2(5), JAK3(5), NR0B2(1), PI3(2), PPP1R13B(1), RPS6KB1(2), SERPINA4(2), SHC1(1), SOS1(7), SOS2(5), SRC(2), STAT6(5), TYK2(10) 41301731 76 56 76 11 24 6 8 24 14 0 0.00198 1.000 1.000 278 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 12 AGA(1), FUCA1(6), FUCA2(3), GLB1(2), HEXA(1), HEXB(1), LCT(13), MAN2C1(2), MANBA(1), NEU1(2), NEU3(2), NEU4(2) 18761673 36 28 36 11 10 6 6 10 4 0 0.367 1.000 1.000 279 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(1), PSMA2(2), PSMA3(2), PSMA4(1), PSMA5(1), PSMB1(1), PSMB2(1), PSMB3(1), PSMB4(1), PSMB5(1), PSMB6(1), PSMC3(2), RPN1(1), RPN2(1), UBE3A(1) 15318200 18 11 18 6 4 5 4 2 3 0 0.534 1.000 1.000 280 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 GUSB(3), RPE(1), UCHL3(1), UGDH(1), UGT1A1(5), UGT1A10(2), UGT1A3(3), UGT1A4(1), UGT1A5(3), UGT1A6(4), UGT1A7(3), UGT1A9(2), UGT2B15(3), UGT2B4(9) 20876975 41 33 40 13 12 7 6 13 3 0 0.267 1.000 1.000 281 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 18 ABCB1(15), AKT1(2), ATM(12), BAX(1), CDKN1A(2), CPB2(1), CSNK1A1(2), CSNK1D(2), MAPK8(2), MDM2(5), NQO1(1) 23743132 45 34 44 13 11 5 5 14 10 0 0.432 1.000 1.000 282 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(4), AR(4), ESR1(3), ESR2(6), ESRRA(2), HNF4A(7), NPM1(3), NR0B1(1), NR1D1(1), NR1D2(1), NR1H2(4), NR1H3(5), NR1I2(2), NR1I3(1), NR2C2(3), NR2E1(2), NR2F1(1), NR2F2(5), NR3C1(3), NR4A1(3), NR4A2(1), NR5A1(1), NR5A2(2), PGR(9), PPARA(4), PPARG(3), RARB(2), ROR1(3), RORA(1), RORC(4), RXRA(4), RXRG(3), THRA(3), THRB(2), VDR(2) 50022598 105 73 102 26 41 15 14 25 10 0 0.0189 1.000 1.000 283 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOA(1), ALDOB(2), DLD(3), ENO1(2), ENO2(2), ENO3(2), FBP1(3), FBP2(2), G6PC(8), GAPDH(1), GAPDHS(2), GCK(2), GOT1(2), GOT2(1), GPI(2), HK1(4), HK2(5), HK3(5), LDHA(1), LDHAL6B(2), LDHB(2), LDHC(1), PC(4), PCK1(6), PDHA1(6), PDHA2(7), PDHB(1), PFKL(5), PFKP(1), PGAM2(1), PGK1(3), PGK2(1), PKLR(4), TNFAIP1(3), TPI1(1) 50402078 98 71 96 23 38 25 4 20 11 0 0.00211 1.000 1.000 284 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 15 AKT1(2), CREB1(2), MAPK1(4), MAPK3(2), MAPK7(6), MEF2A(4), MEF2B(1), MEF2D(1), NTRK1(3), PLCG1(12), RPS6KA1(5), SHC1(1) 18035138 43 33 41 13 7 9 5 10 11 1 0.275 1.000 1.000 285 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 59 ATP12A(7), ATP4B(2), ATP6AP1(3), ATP6V0A4(3), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(1), ATP6V1G1(1), ATP6V1G3(2), ATP6V1H(1), ATP7A(12), ATP7B(4), COX10(5), COX6B1(1), COX7A1(1), COX7C(1), NDUFA10(4), NDUFA4(1), NDUFB5(1), NDUFS1(2), NDUFS2(1), NDUFV1(2), NDUFV2(1), PPA2(1), SDHA(4), SHMT1(2), UQCRC1(4), UQCRH(2) 45162982 80 55 79 15 16 15 14 25 9 1 0.00402 1.000 1.000 286 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(3), AXIN1(4), BTRC(2), CCND1(4), CREBBP(13), CSNK1A1(2), CSNK1D(2), CSNK2A1(2), CTBP1(5), CTNNB1(3), DVL1(1), FZD1(3), GSK3B(1), MAP3K7(3), NLK(1), PPP2CA(4), WIF1(3), WNT1(1) 34931567 57 37 57 13 11 9 8 15 14 0 0.118 1.000 1.000 287 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 18 AKT1(2), EIF4A1(7), EIF4A2(2), EIF4B(3), EIF4E(2), EIF4G1(5), EIF4G2(1), EIF4G3(7), MKNK1(2), PPP2CA(4), RPS6KB1(2), TSC1(2), TSC2(6) 27378252 45 33 45 11 12 8 6 13 6 0 0.147 1.000 1.000 288 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 24 ADCY1(5), AKT1(2), CAMK2A(3), CAMK2D(1), CAMK2G(2), CREB1(2), GNAS(4), MAPK1(4), MAPK3(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), PRKCA(6), RAC1(1), RPS6KA1(5), RPS6KA5(2), SOS1(7) 30148353 51 38 51 11 20 4 6 8 11 2 0.0649 1.000 1.000 289 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(3), DLG4(5), EPHB2(5), F2(4), F2RL1(4), F2RL3(3), MAP2K5(2), MAPK1(4), MAPK7(6), MAPK8(2), MYEF2(3), PLD1(8), PLD3(1), PTK2(2), RAF1(2), RASAL1(5), SRC(2), TEC(4), VAV1(9) 32644368 74 52 73 20 24 11 9 19 11 0 0.0806 1.000 1.000 290 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(3), GLI2(6), GLI3(6), GSK3B(1), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), SHH(3), SMO(3), SUFU(4) 19834608 31 23 31 10 9 6 3 6 7 0 0.361 1.000 1.000 291 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(3), ADH1B(4), ADH5(1), ADH6(3), ADH7(2), ADHFE1(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH7A1(2) 15756123 33 19 33 13 12 2 3 14 2 0 0.602 1.000 1.000 292 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(1), ACAA1(1), ACAA2(3), ACADM(2), ACADS(5), ACAT2(1), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH6A1(5), ALDH7A1(2), AOX1(9), BCAT1(1), BCKDHA(1), BCKDHB(2), DBT(3), DLD(3), ECHS1(3), EHHADH(2), HADHA(3), HIBADH(1), HIBCH(2), HMGCS1(2), HMGCS2(3), HSD17B4(3), MCCC1(4), MCCC2(5), MUT(2), OXCT1(1), OXCT2(1), PCCA(3), PCCB(4) 51066936 94 60 90 22 32 22 9 16 15 0 0.0135 1.000 1.000 293 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(3), ABAT(1), ADSL(4), AGXT(2), AGXT2(2), ASL(2), ASNS(4), ASPA(1), CAD(8), CRAT(2), DARS(1), GAD1(3), GAD2(1), GOT1(2), GOT2(1), NARS(1), PC(4) 30931428 42 26 42 8 8 10 4 12 8 0 0.0579 1.000 1.000 294 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(4), COL4A2(7), COL4A3(1), COL4A4(11), COL4A5(11), COL4A6(9), P4HB(1), SLC23A1(2), SLC23A2(3), SLC2A1(4), SLC2A3(5) 29859075 58 43 58 20 19 14 7 10 7 1 0.150 1.000 1.000 295 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS2(2), DHRS3(1), DHRS7(1), DHRSX(1), ESCO1(2), ESCO2(2), PNPLA3(1), SH3GLB1(3) 19677792 13 6 12 3 5 4 1 2 1 0 0.287 1.000 1.000 296 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ALDH1A1(2), ALDH1A2(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3B2(3), AOC2(1), ASPA(1), CNDP1(4), DDC(5), HAL(3), HARS(4), HDC(5), HNMT(1), MAOA(3), MAOB(2), PRPS1(1), PRPS2(5) 29032709 58 41 58 17 30 7 5 13 3 0 0.108 1.000 1.000 297 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 38 ATF2(2), CREB1(2), DAXX(5), DDIT3(2), ELK1(5), MAP3K1(9), MAP3K5(4), MAP3K7(3), MAP3K9(6), MAPKAPK2(2), MAPKAPK5(2), MEF2A(4), MEF2B(1), MEF2D(1), MKNK1(2), PLA2G4A(7), RAC1(1), RIPK1(4), RPS6KA5(2), SHC1(1), STAT1(4), TGFB2(2), TGFB3(1), TGFBR1(4), TRADD(1), TRAF2(2) 42896650 79 58 77 18 17 18 13 17 13 1 0.0303 1.000 1.000 298 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 11 AKT1(2), CHRNB1(2), CHRNG(3), MUSK(5), PTK2(2), PTK2B(5), RAPSN(1), SRC(2), TERT(5), YWHAH(2) 14947190 29 24 29 10 10 1 3 8 7 0 0.413 1.000 1.000 299 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 32 AGT(3), AGTR1(1), ATF2(2), CALM1(1), CALM3(1), ELK1(5), MAP2K1(1), MAP2K2(1), MAP3K1(9), MAPK1(4), MAPK3(2), MAPK8(2), MEF2A(4), MEF2B(1), MEF2D(1), PAK1(3), PRKCA(6), PTK2(2), PTK2B(5), RAC1(1), RAF1(2), SHC1(1), SOS1(7), SRC(2), SYT1(2) 36716485 69 49 66 16 13 15 10 12 17 2 0.0304 1.000 1.000 300 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GSS(2), NFKB1(2), NOX1(1), RELA(1), TNF(1), XDH(11) 11807172 18 11 18 9 5 5 0 7 1 0 0.747 1.000 1.000 301 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 40 CALM1(1), CALM3(1), CD3D(1), CD3E(2), CD3G(1), ELK1(5), FOS(2), FYN(2), LAT(2), LCK(1), MAP2K1(1), MAP3K1(9), MAPK3(2), MAPK8(2), NFATC1(2), NFATC2(7), NFATC3(2), NFATC4(5), NFKB1(2), NFKBIA(3), PLCG1(12), PPP3CA(1), PPP3CB(1), PPP3CC(1), PRKCA(6), PTPN7(2), RAC1(1), RAF1(2), RASA1(4), RELA(1), SHC1(1), SOS1(7), SYT1(2), VAV1(9), ZAP70(8) 52364662 111 76 107 26 31 19 14 27 18 2 0.00622 1.000 1.000 302 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(1), ACACA(17), ACADL(1), ACADM(2), ACAT2(1), ALDH1A1(2), ALDH1A2(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH6A1(5), ECHS1(3), EHHADH(2), HADHA(3), LDHA(1), LDHB(2), LDHC(1), MLYCD(4), MUT(2), PCCA(3), PCCB(4), SDS(1), SUCLA2(1), SUCLG1(2), SUCLG2(1) 39288675 77 48 77 21 23 20 6 17 11 0 0.0981 1.000 1.000 303 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(4), AP2A1(1), AP2M1(1), BIN1(2), CALM1(1), CALM3(1), DNM1(1), EPN1(1), EPS15(3), PICALM(3), PPP3CA(1), PPP3CB(1), PPP3CC(1), SYNJ1(6), SYNJ2(11), SYT1(2) 25660797 40 26 40 12 13 5 7 6 9 0 0.218 1.000 1.000 304 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(5), CALM1(1), CALM3(1), CREB1(2), ELK1(5), FOS(2), GNAI1(4), GNAS(4), GNB1(1), MAP2K1(1), MAPK3(2), NFATC1(2), NFATC2(7), NFATC3(2), NFATC4(5), PLCG1(12), PPP3CA(1), PPP3CB(1), PPP3CC(1), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), PRKCA(6), RAF1(2), RPS6KA3(4), SYT1(2) 41577812 78 61 76 21 21 9 10 19 17 2 0.103 1.000 1.000 305 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(17), ACACB(18), ACAT2(1), ACOT12(1), ACSS1(1), ACSS2(4), ACYP1(1), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH7A1(2), DLD(3), HAGH(1), LDHA(1), LDHAL6A(1), LDHAL6B(2), LDHB(2), LDHC(1), LDHD(1), ME1(2), ME2(2), ME3(1), PC(4), PCK1(6), PDHA1(6), PDHA2(7), PDHB(1), PKLR(4) 55547755 106 81 104 27 39 22 7 25 13 0 0.0194 1.000 1.000 306 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B10(3), B4GALT2(1), G6PC(8), G6PC2(1), GAA(6), GALK1(1), GALK2(1), GALT(1), GANC(5), GCK(2), GLA(2), GLB1(2), HK1(4), HK2(5), HK3(5), HSD3B7(1), LCT(13), MGAM(13), PFKL(5), PFKP(1), PGM1(1), PGM3(1), UGP2(1) 45924164 83 54 83 20 44 9 7 16 7 0 0.0106 1.000 1.000 307 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 35 BTK(3), CALM1(1), CALM3(1), ELK1(5), FCER1A(4), FOS(2), LYN(2), MAP2K1(1), MAP3K1(9), MAPK1(4), MAPK3(2), MAPK8(2), NFATC1(2), NFATC2(7), NFATC3(2), NFATC4(5), PAK2(2), PLA2G4A(7), PLCG1(12), PPP3CA(1), PPP3CB(1), PPP3CC(1), RAF1(2), SHC1(1), SOS1(7), SYT1(2), VAV1(9) 46678358 97 67 93 25 19 22 16 26 13 1 0.0244 1.000 1.000 308 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 31 CRKL(2), DOCK1(3), ELK1(5), FOS(2), HGF(4), ITGA1(4), ITGB1(3), MAP2K1(1), MAP2K2(1), MAP4K1(3), MAPK1(4), MAPK3(2), MAPK8(2), MET(13), PAK1(3), PTK2(2), PTK2B(5), PXN(1), RAF1(2), RASA1(4), SOS1(7), SRC(2), STAT3(3) 45517708 78 54 77 20 22 10 10 18 17 1 0.0504 1.000 1.000 309 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(3), POLR2A(9), POLR2B(4), POLR2C(2), POLR2G(1), POLRMT(3) 16093301 22 17 22 8 6 3 3 7 3 0 0.618 1.000 1.000 310 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 11 APC(3), AXIN1(4), BTRC(2), CTNNB1(3), DLL1(1), DVL1(1), FZD1(3), GSK3B(1), PSEN1(1), WNT1(1) 20633462 20 16 20 9 3 2 2 6 7 0 0.904 1.000 1.000 311 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAX(1), BCL2(2), CASP8(2), CYCS(2), MAP2K1(1), MAP3K1(9), MAPK1(4), MAPK3(2), MAPK8(2), NFKB1(2), NSMAF(3), RAF1(2), RELA(1), RIPK1(4), SMPD1(1), TNFRSF1A(1), TRADD(1), TRAF2(2) 24399423 42 34 40 13 11 10 7 4 9 1 0.224 1.000 1.000 312 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 25 ACLY(4), ACO1(6), ACO2(4), CLYBL(5), DLD(3), FH(1), IDH3A(1), IDH3B(1), OGDH(1), OGDHL(7), PC(4), PCK1(6), SDHA(4), SDHC(2), SUCLA2(1), SUCLG1(2), SUCLG2(1) 33465035 53 42 52 15 13 10 8 16 6 0 0.161 1.000 1.000 313 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(3), IL5(1), MAF(3), MAP2K3(6), NFATC1(2), NFATC2(7), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1) 14507874 27 19 27 11 12 1 3 6 5 0 0.422 1.000 1.000 314 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ALDH1A3(5), ALDH3A1(6), ALDH3B2(3), AOC2(1), DDC(5), EPX(7), GOT1(2), GOT2(1), HPD(1), LPO(5), MAOA(3), MAOB(2), MPO(4), PRDX1(1), TAT(3), TPO(10) 26119457 59 42 58 18 30 9 5 10 4 1 0.0803 1.000 1.000 315 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ACY3(1), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3B2(3), ALDH7A1(2), AMDHD1(2), AOC2(1), ASPA(1), CARM1(1), CNDP1(4), DDC(5), FTCD(4), HAL(3), HARS(4), HARS2(1), HDC(5), HNMT(1), LCMT1(3), LCMT2(2), MAOA(3), MAOB(2), METTL2B(3), METTL6(2), PRMT2(2), PRMT5(4), PRMT6(1), PRMT7(1), PRMT8(5), PRPS1(1), PRPS2(5), UROC1(2), WBSCR22(2) 47096984 92 60 92 26 40 10 10 22 10 0 0.0536 1.000 1.000 316 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 20 AKT1(2), BCL2(2), BCR(3), CRKL(2), FOS(2), JAK2(5), MAP2K1(1), MAP3K1(9), MAPK3(2), MAPK8(2), RAF1(2), SOS1(7), STAT1(4), STAT5A(1), STAT5B(2) 28876451 46 33 44 12 9 10 6 11 8 2 0.108 1.000 1.000 317 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(1), GPLD1(1), PGAP1(3), PIGA(3), PIGB(1), PIGC(1), PIGF(1), PIGG(1), PIGN(2), PIGO(5), PIGQ(3), PIGS(2), PIGT(1), PIGU(2), PIGW(2), PIGX(1), PIGZ(2) 28358561 32 15 32 8 11 3 6 7 5 0 0.199 1.000 1.000 318 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 28 ATF1(1), CREB1(2), DUSP4(1), DUSP9(2), EEF2K(2), EIF4E(2), MAP2K1(1), MAP2K2(1), MAP3K8(4), MAPK1(4), MAPK3(2), MKNK1(2), NFKB1(2), RPS6KA1(5), RPS6KA2(5), RPS6KA3(4), SHC1(1), SOS1(7), SOS2(5), TRAF3(1) 33356938 54 33 54 15 15 5 7 16 10 1 0.247 1.000 1.000 319 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(3), CDH1(4), CREBBP(13), EP300(6), MAP2K1(1), MAP3K7(3), MAPK3(2), SKIL(3), TGFB2(2), TGFB3(1), TGFBR1(4), TGFBR2(5) 30471747 47 28 47 11 10 9 7 13 7 1 0.153 1.000 1.000 320 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(1), ACADM(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH7A1(2), AOC2(1), CNDP1(4), DPYD(6), DPYS(5), ECHS1(3), EHHADH(2), GAD1(3), GAD2(1), HADHA(3), HIBCH(2), MLYCD(4), SMS(1), SRM(2) 32059072 58 33 57 18 19 10 4 16 9 0 0.202 1.000 1.000 321 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(3), AMT(3), ATIC(1), ATP6V0C(1), DHFR(1), GART(4), MTHFD1(3), MTHFD1L(1), MTHFR(7), MTHFS(2), MTR(2), SHMT1(2) 21244740 30 13 30 10 7 7 7 3 5 1 0.288 1.000 1.000 322 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(4), ABAT(1), ACADS(5), ACAT2(1), ALDH1A1(2), ALDH1A2(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH5A1(2), ECHS1(3), EHHADH(2), GAD1(3), GAD2(1), HADHA(3), L2HGDH(1), OXCT1(1), PDHA1(6), PDHA2(7), PDHB(1), SDS(1) 30627195 62 46 59 21 21 13 4 11 13 0 0.164 1.000 1.000 323 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(1), MAPK8(2), NFKB1(2), RELA(1), TNFRSF13B(1), TNFRSF17(1), TNFSF13B(1), TRAF2(2), TRAF3(1), TRAF5(3) 17285578 15 10 15 9 6 4 2 1 2 0 0.845 1.000 1.000 324 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CALM1(1), CALM3(1), CAMK1(2), CAMK1G(1), CAMK2A(3), CAMK2D(1), CAMK2G(2), CAMK4(3), ESRRA(2), HDAC5(1), MEF2A(4), MEF2B(1), MEF2D(1), PPARA(4), PPP3CA(1), PPP3CB(1), PPP3CC(1), SLC2A4(2), SYT1(2), YWHAH(2) 24081629 36 21 36 11 8 9 5 5 9 0 0.240 1.000 1.000 325 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP1(1), ACPP(4), ACPT(2), ALPI(2), ALPP(7), ALPPL2(6), CYP19A1(2), CYP1A2(4), CYP2A13(2), CYP2A7(1), CYP2B6(6), CYP2C18(4), CYP2C19(5), CYP2C8(4), CYP2C9(3), CYP2D6(2), CYP2E1(2), CYP2F1(1), CYP3A4(5), CYP3A5(4), CYP3A7(2), CYP4B1(5), CYP51A1(2), PON1(4) 34718056 80 71 78 23 38 6 8 15 13 0 0.111 1.000 1.000 326 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 26 ARHGDIB(1), CASP10(1), CASP8(2), CFLAR(1), DAXX(5), DFFA(2), FAF1(4), LMNA(2), LMNB2(3), MAP3K1(9), MAP3K7(3), MAPK8(2), PAK1(3), PAK2(2), PRKDC(14), PTPN13(4), RIPK2(1), SPTAN1(8) 46493862 67 46 64 13 13 19 11 14 9 1 0.0112 1.000 1.000 327 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(4), ALG5(3), B4GALT2(1), DPAGT1(2), DPM1(3), FUT8(7), MAN1A1(3), MAN1B1(1), MGAT1(3), MGAT2(3), MGAT3(3), MGAT4A(1), MGAT5(2), RPN1(1), RPN2(1), ST6GAL1(2) 23603810 40 27 40 12 10 11 5 5 9 0 0.173 1.000 1.000 328 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 B4GALT2(1), FBP2(2), G6PC(8), GAA(6), GALK1(1), GALK2(1), GALT(1), GANAB(4), GCK(2), GLA(2), GLB1(2), HK1(4), HK2(5), HK3(5), LCT(13), MGAM(13), PFKP(1), PGM1(1), PGM3(1) 38698990 73 49 73 20 40 9 6 12 6 0 0.0381 1.000 1.000 329 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(3), AGTR2(4), CALM1(1), CALM3(1), CAMK2A(3), CAMK2D(1), CAMK2G(2), F2(4), FYN(2), GNA11(1), GNAI1(4), GNB1(1), JAK2(5), MAP2K1(1), MAP2K2(1), MAPK1(4), MAPK3(2), MAPK8(2), MYLK(7), PLCG1(12), PRKCA(6), PTK2B(5), RAF1(2), SHC1(1), SOS1(7), STAT1(4), STAT3(3), STAT5A(1), SYT1(2) 49530850 92 64 90 25 22 11 18 24 14 3 0.0584 1.000 1.000 330 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(1), ALDH4A1(2), ALDH5A1(2), CAD(8), CPS1(8), EARS2(1), EPRS(5), GAD1(3), GAD2(1), GCLC(1), GFPT1(5), GFPT2(3), GLS(4), GLS2(1), GLUD1(4), GLUD2(4), GLUL(2), GNPNAT1(2), GOT1(2), GOT2(1), GSS(2), NADSYN1(5), PPAT(2), QARS(5) 46864475 74 51 74 16 15 13 14 21 11 0 0.0370 1.000 1.000 331 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(4), AADAC(1), ABAT(1), ACADS(5), ACAT2(1), ACSM1(7), AKR1B10(3), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH5A1(2), ALDH7A1(2), BDH1(1), BDH2(1), ECHS1(3), EHHADH(2), GAD1(3), GAD2(1), HADHA(3), HMGCS1(2), HMGCS2(3), HSD17B4(3), HSD3B7(1), ILVBL(5), L2HGDH(1), OXCT1(1), OXCT2(1), PDHA1(6), PDHA2(7), PDHB(1), PLA1A(4), PPME1(1) 48179369 92 62 89 27 28 14 7 25 18 0 0.0946 1.000 1.000 332 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(3), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH7A1(2), CYP2C19(5), CYP2C9(3), DHRS2(2), DHRS3(1), DHRS7(1), DHRSX(1), ECHS1(3), EHHADH(2), ESCO1(2), ESCO2(2), HADHA(3), PNPLA3(1), SH3GLB1(3), YOD1(1) 36702728 51 32 50 14 23 9 5 7 7 0 0.105 1.000 1.000 333 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BLNK(2), BTK(3), CALM1(1), CALM3(1), CD79A(1), ELK1(5), FOS(2), LYN(2), MAP2K1(1), MAP3K1(9), MAPK3(2), MAPK8(2), NFATC1(2), NFATC2(7), NFATC3(2), NFATC4(5), PLCG1(12), PPP3CA(1), PPP3CB(1), PPP3CC(1), PRKCA(6), RAC1(1), RAF1(2), SHC1(1), SOS1(7), SYT1(2), VAV1(9) 45429368 90 61 86 26 21 18 12 22 15 2 0.0773 1.000 1.000 334 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 MRPL13(1), MRPS7(2), RPL10L(3), RPL11(2), RPL13A(2), RPL18A(1), RPL22L1(1), RPL24(1), RPL29(1), RPL32(1), RPL35(2), RPL36A(2), RPL37A(1), RPL3L(1), RPL6(1), RPL7(3), RPS11(1), RPS12(2), RPS18(2), RPS2(1), RPS21(1), RPS24(1), RPS3(3), RPS5(1) 26894393 37 24 36 9 12 2 4 9 10 0 0.514 1.000 1.000 335 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 7 ACO2(4), FH(1), OGDH(1), SDHA(4), SUCLA2(1) 10221978 11 9 10 8 4 1 4 1 1 0 0.907 1.000 1.000 336 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(1), IARS(4), IARS2(3), ILVBL(5), LARS(4), PDHA1(6), PDHA2(7), PDHB(1), VARS(4), VARS2(3) 22075375 38 26 36 11 6 10 4 12 6 0 0.329 1.000 1.000 337 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1R(5), DDX20(1), E2F1(1), E2F4(1), ETS1(5), ETV3(1), FOS(2), HDAC2(7), HDAC5(1), NCOR2(9), RBL1(6), RBL2(3), SIN3A(5), SIN3B(1) 30957249 48 30 47 15 10 7 5 12 14 0 0.438 1.000 1.000 338 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(5), ADRBK2(7), ARRB2(1), CALM1(1), CALM3(1), CALML3(1), CALML6(1), CAMK2A(3), CAMK2D(1), CAMK2G(2), CLCA1(5), CLCA2(5), CLCA4(2), CNGA3(4), CNGA4(4), CNGB1(5), GNAL(1), GUCA1A(1), GUCA1C(1), PDC(2), PDE1C(9), PRKACG(1), PRKG1(2), PRKG2(6), PRKX(1) 36222503 72 51 72 22 31 12 4 13 12 0 0.110 1.000 1.000 339 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 43 CBL(2), CD28(2), CD3D(1), CSK(2), CTLA4(1), DAG1(3), DTYMK(1), EPHB2(5), FBXW7(5), GRAP2(2), ITK(1), LAT(2), LCK(1), LCP2(1), MAPK1(4), NFAT5(3), NFKB1(2), NFKB2(2), NFKBIA(3), NFKBIE(3), PAK1(3), PAK2(2), PAK3(3), PAK4(3), PAK6(3), PAK7(5), PLCG1(12), PTPRC(9), RAF1(2), RASGRP1(2), RASGRP2(3), RASGRP3(2), RASGRP4(3), SOS1(7), SOS2(5), VAV1(9), ZAP70(8) 65416984 127 89 123 29 37 24 15 32 19 0 0.0101 1.000 1.000 340 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CALM1(1), CALM3(1), CHUK(1), EGR2(2), EGR3(2), MAP3K1(9), NFATC1(2), NFATC2(7), NFKB1(2), NFKBIA(3), PLCG1(12), PPP3CA(1), PPP3CB(1), PPP3CC(1), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), RELA(1), SYT1(2), VIP(2), VIPR2(2) 33245490 57 45 53 18 13 10 6 18 10 0 0.264 1.000 1.000 341 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CD4(2), CSF2(2), HLA-DRA(4), HLA-DRB1(1), IFNB1(2), IFNG(2), IL10(1), IL12B(4), IL15(2), IL1A(1), IL3(2), IL5(1), IL6(2), IL7(1), PDGFA(1), TGFB2(2), TGFB3(1), TNF(1) 15750234 32 25 32 12 8 5 6 9 4 0 0.483 1.000 1.000 342 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 31 A1BG(2), AKT1(2), BTK(3), CDKN2A(6), GSK3B(1), IARS(4), INPP5D(5), PDK1(2), PPP1R13B(1), RPS6KA1(5), RPS6KA2(5), RPS6KA3(4), RPS6KB1(2), SFN(3), SHC1(1), SOS1(7), SOS2(5), TEC(4), YWHAB(2), YWHAE(3), YWHAG(1), YWHAH(2), YWHAQ(1), YWHAZ(1) 39150151 72 50 71 20 12 12 12 23 13 0 0.166 1.000 1.000 343 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(3), DARS(1), EPRS(5), FARS2(3), GARS(3), HARS(4), IARS(4), KARS(2), LARS(4), MARS(7), MARS2(2), NARS(1), QARS(5), RARS(3), SARS(1), TARS(1), WARS(1), WARS2(2), YARS(1) 38024325 53 35 53 12 8 13 6 18 8 0 0.188 1.000 1.000 344 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(6), ABCC2(1), ABCG2(3), BCHE(2), CES1(3), CES2(2), CYP3A4(5), CYP3A5(4), UGT1A1(5), UGT1A10(2), UGT1A3(3), UGT1A4(1), UGT1A5(3), UGT1A6(4), UGT1A7(3), UGT1A9(2) 27104779 49 39 48 17 17 4 10 11 7 0 0.283 1.000 1.000 345 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 49 AGT(3), AKT1(2), CALM1(1), CALM3(1), CALR(2), CAMK1(2), CAMK1G(1), CAMK4(3), CREBBP(13), CSNK1A1(2), ELSPBP1(3), F2(4), GATA4(3), GSK3B(1), IGF1(3), MAP2K1(1), MAPK1(4), MAPK3(2), MAPK8(2), MYH2(25), NFATC1(2), NFATC2(7), NFATC3(2), NFATC4(5), NPPA(2), PPP3CA(1), PPP3CB(1), PPP3CC(1), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), RAF1(2), RPS6KB1(2), SYT1(2) 55876120 110 76 109 27 37 10 15 28 19 1 0.0112 1.000 1.000 346 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 ACVR1(3), APC(3), ATF2(2), AXIN1(4), BMP10(2), BMP2(1), BMP4(3), BMP5(8), BMPR1A(1), BMPR2(1), CHRD(2), CTNNB1(3), DVL1(1), FZD1(3), GATA4(3), GSK3B(1), MAP3K7(3), MYL2(2), NPPA(2), RFC1(2), TGFB2(2), TGFB3(1), TGFBR1(4), TGFBR2(5), TGFBR3(3), WNT1(1) 43278799 66 46 66 12 19 11 9 12 15 0 0.0134 1.000 1.000 347 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 19 AKT1(2), EIF4A1(7), EIF4A2(2), EIF4E(2), EIF4G1(5), EIF4G2(1), EIF4G3(7), GHR(4), IRS1(8), MAPK1(4), MAPK3(2), MKNK1(2), PABPC1(5), PRKCA(6), RPS6KB1(2) 27965761 59 40 59 17 16 10 9 11 11 2 0.249 1.000 1.000 348 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(3), AMT(3), ATIC(1), DHFR(1), FTCD(4), GART(4), MTFMT(1), MTHFD1(3), MTHFD1L(1), MTHFR(7), MTHFS(2), MTR(2), SHMT1(2) 22492513 34 17 34 12 9 7 7 4 6 1 0.360 1.000 1.000 349 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 32 AKT1(2), ASAH1(2), DAG1(3), DRD2(1), EPHB2(5), ITPR1(9), ITPR2(15), ITPR3(18), KCNJ3(2), KCNJ5(5), KCNJ9(1), MAPK1(4), PI3(2), PIK3CB(7), PITX2(7), PLCB1(4), PLCB2(7), PLCB3(4), PLCB4(4), RAF1(2), SHC1(1), SOS1(7), SOS2(5), SRC(2), STAT3(3), TERF2IP(1) 64713989 123 82 123 28 34 20 24 32 12 1 0.00374 1.000 1.000 350 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCL11(2), CCR3(2), CFL1(1), GNAS(4), GNB1(1), LIMK1(4), MAP2K1(1), MAPK1(4), MAPK3(2), MYL2(2), NOX1(1), PIK3C2G(10), PLCB1(4), PPP1R12B(1), PRKCA(6), PTK2(2), RAF1(2), ROCK2(5) 29930335 54 44 54 15 13 5 12 13 9 2 0.270 1.000 1.000 351 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 23 GH1(2), GHR(4), INS(1), INSR(6), IRS1(8), JAK2(5), MAP2K1(1), MAPK1(4), MAPK3(2), PLCG1(12), PRKCA(6), PTPN6(1), RAF1(2), RPS6KA1(5), SHC1(1), SLC2A4(2), SOCS1(1), SOS1(7), SRF(3), STAT5A(1), STAT5B(2) 34806143 76 57 74 23 16 15 11 20 12 2 0.205 1.000 1.000 352 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 41 AKT1(2), CAB39(2), EIF4B(3), FIGF(2), IGF1(3), INS(1), MAPK1(4), MAPK3(2), PGF(1), PIK3CB(7), PIK3CD(3), PIK3CG(12), PIK3R2(4), PIK3R3(2), PIK3R5(4), PRKAA1(3), PRKAA2(2), RICTOR(2), RPS6KA1(5), RPS6KA2(5), RPS6KA3(4), RPS6KA6(5), RPS6KB1(2), RPS6KB2(3), STK11(1), TSC1(2), TSC2(6), ULK1(2), ULK2(7), VEGFA(3), VEGFB(3), VEGFC(3) 57063273 110 74 109 29 32 15 17 29 16 1 0.0484 1.000 1.000 353 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTN1(3), ACTN2(6), CAPN1(2), CAPNS1(2), CAPNS2(1), ITGA1(4), ITGB1(3), ITGB3(3), PTK2(2), PXN(1), RAC1(1), SPTAN1(8), SRC(2), TLN1(5) 33881972 43 26 43 9 15 3 7 13 5 0 0.0800 1.000 1.000 354 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(5), CD2(1), CD33(6), CD5(2), CD7(3), CSF2(2), IFNB1(2), IFNG(2), IL10(1), IL12B(4), IL3(2), IL5(1), ITGAX(8), TLR2(5), TLR4(2), TLR7(10), TLR9(5) 22060400 61 51 60 23 22 5 7 20 7 0 0.531 1.000 1.000 355 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 24 AKT1(2), APC(3), AXIN1(4), CCND1(4), CD14(1), CTNNB1(3), DVL1(1), FZD1(3), GJA1(5), GNAI1(4), GSK3B(1), IRAK1(3), LBP(5), LEF1(1), LY96(2), NFKB1(2), PPP2CA(4), RELA(1), TLR4(2), TOLLIP(1), WNT1(1) 32092744 53 40 53 17 16 8 10 10 9 0 0.305 1.000 1.000 356 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 24 GUSB(3), RPE(1), UGDH(1), UGP2(1), UGT1A1(5), UGT1A10(2), UGT1A3(3), UGT1A4(1), UGT1A5(3), UGT1A6(4), UGT1A7(3), UGT1A9(2), UGT2A1(9), UGT2B10(4), UGT2B11(5), UGT2B15(3), UGT2B17(2), UGT2B28(8), UGT2B4(9), UGT2B7(4), XYLB(1) 31120904 74 58 72 25 21 8 12 28 5 0 0.426 1.000 1.000 357 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 46 AKT1(2), BRD4(1), CBL(2), CDKN2A(6), FLOT1(1), FLOT2(3), GSK3B(1), INPPL1(8), IRS1(8), IRS2(1), IRS4(7), LNPEP(3), MAPK1(4), MAPK3(2), PARD3(3), PARD6A(1), PDK1(2), PIK3CD(3), PTPN1(1), RAF1(2), RPS6KA1(5), RPS6KA2(5), RPS6KA3(4), RPS6KB1(2), SFN(3), SHC1(1), SLC2A4(2), SORBS1(3), SOS1(7), SOS2(5), YWHAB(2), YWHAE(3), YWHAG(1), YWHAH(2), YWHAQ(1), YWHAZ(1) 65171607 108 73 107 25 18 14 18 32 25 1 0.0306 1.000 1.000 358 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(3), AARS2(1), ABAT(1), ACY3(1), ADSL(4), ADSSL1(1), AGXT(2), AGXT2(2), ASL(2), ASNS(4), ASPA(1), ASS1(4), CAD(8), CRAT(2), DARS(1), DARS2(2), DLD(3), GAD1(3), GAD2(1), GOT1(2), GOT2(1), NARS(1), NARS2(1), PC(4), PDHA1(6), PDHA2(7), PDHB(1) 44935938 69 48 66 18 18 17 6 15 13 0 0.0939 1.000 1.000 359 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 18 ABL1(6), ATM(12), BRCA1(6), CDKN1A(2), CHEK1(6), CHEK2(3), MAPK8(2), MDM2(5), MRE11A(3), NFKB1(2), NFKBIA(3), RAD50(6), RBBP8(3), RELA(1) 34444498 60 40 60 17 16 10 9 16 9 0 0.335 1.000 1.000 360 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(3), CAMK2D(1), CAMK2G(2), DAG1(3), ITPR1(9), ITPR2(15), ITPR3(18), NFAT5(3), PDE6A(4), PDE6B(5), PDE6C(7), SLC6A13(4), TF(2) 42628421 76 52 76 24 29 16 11 12 7 1 0.0716 1.000 1.000 361 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 27 ARHGDIB(1), BAG4(1), CASP2(1), CASP8(2), CRADD(2), DFFA(2), LMNA(2), LMNB2(3), MADD(3), MAP3K1(9), MAP3K7(3), MAPK8(2), PAK1(3), PAK2(2), PRKDC(14), RIPK1(4), SPTAN1(8), TNF(1), TNFRSF1A(1), TRADD(1), TRAF2(2) 44108491 67 52 64 17 17 17 10 13 9 1 0.0621 1.000 1.000 362 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 FOS(2), MAP2K1(1), MAPK1(4), MAPK3(2), NFKB1(2), NFKBIA(3), PLCB1(4), PRKCA(6), RAF1(2), RELA(1), TNF(1) 18426233 28 23 28 11 6 3 4 8 5 2 0.536 1.000 1.000 363 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CHUK(1), CREBBP(13), DUSP1(1), EP300(6), IKBKB(2), IL1B(3), MAP2K3(6), MAP3K7(3), NFKB1(2), NFKBIA(3), NR3C1(3), RELA(1), TGFBR1(4), TGFBR2(5), TLR2(5), TNF(1) 35255518 59 41 59 18 14 13 7 14 11 0 0.228 1.000 1.000 364 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ALDH1A3(5), ALDH3A1(6), ALDH3B2(3), AOC2(1), DDC(5), EPX(7), ESCO1(2), ESCO2(2), GOT1(2), GOT2(1), HPD(1), LPO(5), MAOA(3), MAOB(2), MPO(4), PNPLA3(1), SH3GLB1(3), TAT(3), TPO(10) 40655346 66 44 65 19 31 13 5 12 5 0 0.0692 1.000 1.000 365 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 34 ANPEP(5), G6PD(3), GCLC(1), GGT1(3), GPX2(2), GPX5(1), GPX6(1), GSS(2), GSTA1(3), GSTA2(1), GSTA3(1), GSTA4(3), GSTA5(4), GSTK1(2), GSTM4(1), GSTM5(1), GSTT1(1), GSTZ1(3), OPLAH(3) 24200498 41 29 41 14 13 12 6 6 4 0 0.261 1.000 1.000 366 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(1), IFNB1(2), IKBKB(2), IL1A(1), IL1B(3), IL1R1(4), IL1RAP(2), IL1RN(2), IL6(2), IRAK1(3), IRAK2(3), IRAK3(9), MAP2K3(6), MAP3K1(9), MAP3K7(3), MAPK8(2), NFKB1(2), NFKBIA(3), RELA(1), TGFB2(2), TGFB3(1), TNF(1), TOLLIP(1) 35216894 65 49 63 20 16 17 9 13 10 0 0.136 1.000 1.000 367 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(11), CALM1(1), CALM3(1), CAPNS1(2), CAPNS2(1), EP300(6), HDAC2(7), MEF2D(1), NFATC1(2), NFATC2(7), PPP3CA(1), PPP3CB(1), PPP3CC(1), PRKCA(6), SYT1(2) 28934777 50 34 50 18 14 7 8 11 9 1 0.455 1.000 1.000 368 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 24 CPEB1(3), ERBB2(3), ERBB4(5), ETS1(5), ETV6(4), ETV7(1), FMN2(3), MAP2K1(1), MAPK1(4), MAPK3(2), NOTCH2(16), NOTCH3(7), NOTCH4(10), PIWIL1(2), PIWIL2(5), PIWIL3(5), PIWIL4(2), RAF1(2), SOS1(7), SOS2(5), SPIRE1(2), SPIRE2(3) 51873931 97 63 96 26 27 18 15 20 15 2 0.101 1.000 1.000 369 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AMD1(2), CBS(5), CTH(2), DNMT1(4), DNMT3A(11), DNMT3B(4), MARS(7), MARS2(2), MAT1A(2), MTFMT(1), MTR(2), SRM(2), TAT(3) 24608089 47 30 46 17 13 9 3 13 7 2 0.382 1.000 1.000 370 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT1(2), ANKRD6(4), APC(3), AXIN1(4), AXIN2(2), CSNK1A1(2), CTNNB1(3), DACT1(4), DKK1(2), DKK2(5), DKK4(2), DVL1(1), FSTL1(1), GSK3B(1), LRP1(29), MVP(3), NKD1(2), NKD2(4), PSEN1(1), PTPRA(7), SENP2(3), SFRP1(1), WIF1(3) 47989360 89 61 88 26 28 11 9 22 19 0 0.252 1.000 1.000 371 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 AMT(3), ASNS(4), CA1(1), CA12(3), CA13(1), CA14(1), CA2(1), CA5A(1), CA9(1), CPS1(8), CTH(2), GLS(4), GLS2(1), GLUD1(4), GLUD2(4), GLUL(2), HAL(3) 25221894 44 35 44 15 14 8 3 12 7 0 0.434 1.000 1.000 372 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1QA(2), C1QB(1), C1R(2), C1S(5), C2(7), C3(19), C5(7), C6(4), C7(5), C8A(4), C9(2), MASP1(2), MASP2(1), MBL2(4) 25330880 65 44 65 24 24 7 5 19 10 0 0.496 1.000 1.000 373 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM1(1), CALM3(1), DLG4(5), GRIN1(2), GRIN2A(17), GRIN2B(9), GRIN2C(6), GRIN2D(5), NOS1(10), PPP3CA(1), PPP3CB(1), PPP3CC(1), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), PRKCA(6), SYT1(2) 30363151 72 61 72 27 37 7 8 12 7 1 0.275 1.000 1.000 374 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(3), ASAH1(2), CREB1(2), DAG1(3), EPHB2(5), FOS(2), MAPK1(4), MAPK10(1), MAPK8(2), MAPK8IP1(3), MAPK8IP2(4), MAPK8IP3(6), MAPK9(1) 33996203 38 30 38 12 8 7 11 5 7 0 0.267 1.000 1.000 375 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(1), AOC2(1), CES1(3), ESCO1(2), ESCO2(2), LIPA(2), PLA1A(4), PNPLA3(1), PPME1(1), SH3GLB1(3) 30113623 20 11 20 6 6 5 1 6 2 0 0.392 1.000 1.000 376 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 21 ATM(12), ATR(10), BRCA1(6), CCNB1(2), CDC25A(1), CDC25B(1), CDC34(2), CDKN1A(2), CHEK1(6), CHEK2(3), EP300(6), MDM2(5), MYT1(7), PRKDC(14), RPS6KA1(5), WEE1(2), YWHAH(2), YWHAQ(1) 48865857 87 61 87 24 20 13 11 22 20 1 0.296 1.000 1.000 377 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA1(1), ACAA2(3), ACADL(1), ACADM(2), ACADS(5), ACAT2(1), ALDH1A1(2), ALDH1A2(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH6A1(5), AOX1(9), BCAT1(1), BCKDHA(1), BCKDHB(2), ECHS1(3), EHHADH(2), HADHA(3), HIBADH(1), MCCC1(4), MCCC2(5), MUT(2), OXCT1(1), PCCA(3), PCCB(4), SDS(1) 42731475 80 52 76 27 27 21 8 13 11 0 0.187 1.000 1.000 378 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 25 AKT1(2), BCL2(2), GSK3B(1), IL4R(10), IRS1(8), IRS2(1), JAK1(3), JAK3(5), MAP4K1(3), MAPK1(4), MAPK3(2), PDK1(2), PIK3CD(3), PPP1R13B(1), RAF1(2), SHC1(1), SOCS1(1), SOS1(7), SOS2(5), STAT6(5) 38936559 68 53 68 21 16 7 7 22 15 1 0.354 1.000 1.000 379 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 20 ARHGAP5(5), DIAPH1(5), FYN(2), GSN(2), ITGA1(4), ITGB1(3), MAP2K1(1), MAPK1(4), MAPK3(2), MYL2(2), MYLK(7), PTK2(2), PXN(1), RAF1(2), ROCK1(4), SHC1(1), SRC(2), TLN1(5) 39887590 54 36 53 16 14 2 11 16 10 1 0.269 1.000 1.000 380 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(6), AMY2B(6), ENPP1(5), ENPP3(2), G6PC(8), GAA(6), GANAB(4), GBE1(1), GCK(2), GPI(2), GUSB(3), GYS1(1), GYS2(2), HK1(4), HK2(5), HK3(5), MGAM(13), PGM1(1), PGM3(1), PYGB(3), PYGL(6), PYGM(2), SI(11), UCHL3(1), UGDH(1), UGT1A1(5), UGT1A10(2), UGT1A3(3), UGT1A4(1), UGT1A5(3), UGT1A6(4), UGT1A7(3), UGT1A9(2), UGT2B15(3), UGT2B4(9), UXS1(4) 67732493 140 96 139 32 55 23 15 31 16 0 0.00193 1.000 1.000 381 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 35 ARSA(1), ARSD(3), ARSE(6), ASAH1(2), B4GALT6(2), DEGS1(2), DEGS2(2), ENPP7(4), GAL3ST1(2), GALC(1), GLA(2), GLB1(2), LCT(13), NEU1(2), NEU3(2), NEU4(2), PPAP2A(2), PPAP2C(1), SGMS2(3), SGPP1(1), SGPP2(3), SMPD1(1), SMPD2(1), SMPD3(2), SMPD4(1), SPTLC1(2), SPTLC2(2), UGCG(2), UGT8(2) 41633325 71 45 71 24 24 10 12 20 4 1 0.254 1.000 1.000 382 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(1), CREB1(2), CREBBP(13), EP300(6), NCOA3(4), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), RXRA(4) 24573494 35 26 35 13 10 5 2 9 9 0 0.658 1.000 1.000 383 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1A(3), ADH1B(4), ADH5(1), ADH6(3), ADH7(2), ADHFE1(2), AGK(1), AGPAT1(2), AGPAT2(2), AGPAT3(1), AGPAT6(2), AKR1A1(3), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH7A1(2), CEL(4), DAK(2), DGAT1(2), DGKA(4), DGKB(3), DGKD(8), DGKE(3), DGKG(4), DGKH(4), DGKI(2), DGKQ(3), DGKZ(2), GK(1), GK2(5), GLA(2), GLB1(2), GPAM(1), LCT(13), LIPA(2), LIPC(1), LIPF(1), LIPG(4), LPL(2), MGLL(1), PNLIP(2), PNLIPRP1(4), PNPLA3(1), PPAP2A(2), PPAP2C(1) 69729701 130 79 129 32 48 17 16 36 13 0 0.00690 1.000 1.000 384 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(1), ALOX12(1), ALOX15(2), ALOX5(2), CBR1(2), CBR3(1), CYP4F2(3), CYP4F3(6), EPX(7), GGT1(3), LPO(5), LTA4H(4), MPO(4), PLA2G3(5), PLA2G4A(7), PLA2G5(1), PLA2G6(3), PRDX1(1), PTGES2(1), PTGIS(2), PTGS1(3), PTGS2(3), TBXAS1(2), TPO(10) 33130213 79 59 79 26 32 15 6 15 10 1 0.123 1.000 1.000 385 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CHUK(1), CREBBP(13), EP300(6), HDAC3(1), IKBKB(2), NFKB1(2), NFKBIA(3), RELA(1), RIPK1(4), TNF(1), TNFRSF1A(1), TNFRSF1B(3), TRADD(1) 26596690 39 26 39 14 11 6 2 11 9 0 0.515 1.000 1.000 386 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(3), ADH1B(4), ADH6(3), ADH7(2), ADHFE1(2), AGPAT1(2), AGPAT2(2), AGPAT3(1), AKR1A1(3), ALDH1A1(2), ALDH1A2(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), CEL(4), DGAT1(2), DGKA(4), DGKB(3), DGKD(8), DGKE(3), DGKG(4), DGKH(4), DGKQ(3), DGKZ(2), GK(1), GLA(2), GLB1(2), LCT(13), LIPC(1), LIPF(1), LIPG(4), LPL(2), PNLIP(2), PNLIPRP1(4), PPAP2A(2), PPAP2C(1) 57264992 114 72 114 30 42 18 13 30 11 0 0.0162 1.000 1.000 387 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2A1L(1), GTF2A2(1), GTF2E1(3), GTF2F1(1), GTF2H1(3), GTF2H4(2), GTF2IRD1(4), STON1(4), TAF1(12), TAF10(1), TAF1L(13), TAF2(6), TAF4(5), TAF4B(3), TAF5L(2), TAF6(1), TAF6L(1), TAF7(1), TAF7L(6), TAF9(2), TAF9B(1), TBPL1(1), TBPL2(2) 42817761 76 50 76 23 17 11 9 26 12 1 0.380 1.000 1.000 388 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 28 AKT1(2), CABIN1(11), CALM1(1), CALM3(1), CAMK1(2), CAMK1G(1), HDAC5(1), IGF1(3), IGF1R(10), INS(1), INSR(6), MAPK7(6), MEF2A(4), MEF2B(1), MEF2D(1), MYOD1(1), NFATC1(2), NFATC2(7), PPP3CA(1), PPP3CB(1), PPP3CC(1), SYT1(2), YWHAH(2) 36892388 68 48 68 25 19 10 11 16 12 0 0.331 1.000 1.000 389 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 36 ANKHD1(4), EEF1A2(1), EEF1B2(1), EEF1D(3), EEF2(2), EEF2K(2), EIF2AK1(1), EIF2AK2(1), EIF2AK3(3), EIF2B1(1), EIF2B4(1), EIF2S2(2), EIF2S3(3), EIF4A1(7), EIF4A2(2), EIF4E(2), EIF4G1(5), EIF4G3(7), EIF5A(1), EIF5B(1), ETF1(1), GSPT2(6), PABPC1(5), PABPC3(5), PAIP1(1), SLC35A4(1) 51844084 69 50 69 20 15 9 5 22 18 0 0.340 1.000 1.000 390 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 186 ACTB(2), ACTG1(1), ACTN1(3), ACTN2(6), ACTN4(2), AKT1(2), ARHGAP5(5), BCAR1(3), BCL2(2), BIRC2(3), BIRC3(1), CAV3(1), CCND1(4), CCND2(2), CCND3(1), CHAD(1), COL11A1(8), COL11A2(11), COL1A1(4), COL1A2(20), COL2A1(7), COL3A1(9), COL4A1(4), COL4A2(7), COL4A4(11), COL4A6(9), COL5A1(7), COL5A2(4), COL5A3(2), COL6A1(7), COL6A2(6), COL6A3(28), COL6A6(8), COMP(1), CRKL(2), CTNNB1(3), DIAPH1(5), DOCK1(3), EGF(10), ELK1(5), ERBB2(3), FARP2(2), FIGF(2), FLNA(18), FLNB(12), FLNC(16), FLT1(10), FN1(9), FYN(2), GSK3B(1), HGF(4), IBSP(1), IGF1(3), IGF1R(10), ILK(1), ITGA1(4), ITGA10(5), ITGA11(3), ITGA2(5), ITGA2B(2), ITGA3(1), ITGA4(8), ITGA5(3), ITGA6(3), ITGA7(4), ITGA8(6), ITGA9(2), ITGAV(3), ITGB1(3), ITGB3(3), ITGB4(8), ITGB6(9), ITGB7(7), ITGB8(2), KDR(14), LAMA1(16), LAMA2(18), LAMA3(14), LAMA4(5), LAMA5(18), LAMB1(7), LAMB2(1), LAMB3(6), LAMB4(10), LAMC1(5), LAMC2(5), LAMC3(9), MAP2K1(1), MAPK1(4), MAPK10(1), MAPK3(2), MAPK8(2), MAPK9(1), MET(13), MYL2(2), MYL5(1), MYLK(7), MYLK2(1), PAK1(3), PAK2(2), PAK3(3), PAK4(3), PAK6(3), PAK7(5), PARVA(1), PARVB(3), PARVG(1), PDGFA(1), PDGFC(2), PDGFD(4), PDGFRB(4), PGF(1), PIK3CB(7), PIK3CD(3), PIK3CG(12), PIK3R2(4), PIK3R3(2), PIK3R5(4), PIP5K1C(2), PPP1CA(1), PPP1CB(1), PPP1CC(1), PPP1R12A(1), PRKCA(6), PRKCG(4), PTK2(2), PXN(1), RAC1(1), RAC2(1), RAF1(2), RAPGEF1(4), RELN(25), ROCK1(4), ROCK2(5), SHC1(1), SHC2(1), SHC3(1), SHC4(2), SOS1(7), SOS2(5), SPP1(2), SRC(2), THBS1(6), THBS2(6), THBS3(5), THBS4(5), TLN1(5), TLN2(8), TNC(9), TNN(7), TNR(5), TNXB(14), VASP(1), VAV1(9), VAV2(4), VAV3(3), VCL(1), VEGFA(3), VEGFB(3), VEGFC(3), VWF(14), ZYX(2) 428403307 821 388 813 286 260 153 98 189 116 5 0.00713 1.000 1.000 391 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 166 ADCY1(5), ADCY2(7), ADCY3(5), ADCY4(6), ADCY7(3), ADCY8(3), ADCY9(11), ADRA1A(2), ADRA1B(2), ADRB2(1), AGTR1(1), ATP2A1(3), ATP2A2(4), ATP2A3(4), ATP2B2(8), ATP2B3(8), AVPR1A(6), AVPR1B(2), BDKRB1(1), BST1(1), CACNA1A(5), CACNA1B(15), CACNA1C(7), CACNA1D(11), CACNA1E(12), CACNA1F(7), CACNA1G(7), CACNA1H(11), CACNA1I(9), CACNA1S(14), CALM1(1), CALM3(1), CALML3(1), CALML6(1), CAMK2A(3), CAMK2D(1), CAMK2G(2), CAMK4(3), CCKAR(1), CCKBR(2), CD38(1), CHRM1(3), CHRM2(3), CHRM3(4), CHRM5(4), CHRNA7(1), CYSLTR1(2), CYSLTR2(2), DRD1(1), EDNRA(1), EDNRB(1), ERBB2(3), ERBB3(4), ERBB4(5), F2R(2), GNA11(1), GNA14(3), GNA15(1), GNAL(1), GNAS(4), GRIN1(2), GRIN2A(17), GRIN2C(6), GRIN2D(5), GRM1(6), GRM5(6), GRPR(4), HRH1(3), HRH2(3), HTR2A(2), HTR2B(2), HTR2C(4), HTR4(2), HTR5A(8), HTR6(1), HTR7(4), ITPR1(9), ITPR2(15), ITPR3(18), LHCGR(2), LTB4R2(1), MYLK(7), MYLK2(1), NOS1(10), NOS3(10), NTSR1(4), P2RX1(2), P2RX2(2), P2RX3(1), P2RX4(1), P2RX5(2), P2RX7(1), PDE1A(3), PDE1B(2), PDE1C(9), PDGFRB(4), PHKA1(5), PHKA2(5), PHKB(1), PHKG1(3), PLCB1(4), PLCB2(7), PLCB3(4), PLCB4(4), PLCD1(4), PLCD3(2), PLCE1(10), PLCG1(12), PLCG2(12), PLCZ1(5), PPID(2), PPP3CA(1), PPP3CB(1), PPP3CC(1), PRKACG(1), PRKCA(6), PRKCG(4), PRKX(1), PTAFR(2), PTGER3(1), PTGFR(7), PTK2B(5), RYR1(16), RYR2(58), RYR3(28), SLC25A4(1), SLC25A5(4), SLC25A6(1), SLC8A1(3), SLC8A2(3), SLC8A3(2), TACR2(2), TACR3(7), TBXA2R(1), TNNC1(1), TNNC2(1), TRHR(2), TRPC1(2), VDAC1(1), VDAC2(2), VDAC3(3) 314881319 671 362 664 236 281 99 72 129 87 3 0.00660 1.000 1.000 392 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 135 ACTB(2), ACTG1(1), CHAD(1), COL11A1(8), COL11A2(11), COL17A1(5), COL1A1(4), COL1A2(20), COL2A1(7), COL3A1(9), COL4A1(4), COL4A2(7), COL4A4(11), COL4A6(9), COL5A1(7), COL5A2(4), COL5A3(2), COL6A1(7), COL6A2(6), COL6A3(28), COL6A6(8), COMP(1), DES(3), DSC1(6), DSC2(5), DSC3(9), DSG1(8), DSG2(7), DSG3(11), DSG4(7), FN1(9), GJA1(5), GJA10(2), GJA3(1), GJA4(1), GJA8(1), GJA9(1), GJB2(1), GJB3(2), GJB4(2), GJB6(2), GJC1(1), GJC3(2), GJD2(3), GJD4(1), IBSP(1), INA(1), ITGA6(3), ITGB4(8), KRT1(4), KRT12(3), KRT13(6), KRT14(2), KRT16(5), KRT17(3), KRT18(3), KRT19(3), KRT2(3), KRT20(5), KRT23(2), KRT24(3), KRT25(5), KRT27(2), KRT28(6), KRT3(4), KRT31(4), KRT32(1), KRT33A(7), KRT33B(3), KRT34(4), KRT35(4), KRT36(5), KRT37(7), KRT38(1), KRT39(4), KRT4(2), KRT40(3), KRT5(4), KRT6A(2), KRT6B(5), KRT6C(3), KRT7(1), KRT71(4), KRT73(5), KRT74(1), KRT75(6), KRT76(2), KRT77(1), KRT78(3), KRT79(6), KRT8(5), KRT81(4), KRT82(1), KRT83(4), KRT84(5), KRT86(4), KRT9(4), LAMA1(16), LAMA2(18), LAMA3(14), LAMA4(5), LAMA5(18), LAMB1(7), LAMB2(1), LAMB3(6), LAMB4(10), LAMC1(5), LAMC2(5), LAMC3(9), LMNA(2), LMNB2(3), NES(3), PRPH(1), RELN(25), SPP1(2), THBS1(6), THBS2(6), THBS3(5), THBS4(5), TNC(9), TNN(7), TNR(5), TNXB(14), VIM(2), VWF(14) 294998816 662 350 655 259 253 141 58 137 71 2 0.138 1.000 1.000 393 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 229 ADCYAP1R1(5), ADORA3(2), ADRA1A(2), ADRA1B(2), ADRA2A(1), ADRA2B(2), ADRA2C(3), ADRB2(1), AGTR1(1), AGTR2(4), AVPR1A(6), AVPR1B(2), AVPR2(4), BDKRB1(1), BRS3(1), C3AR1(3), C5AR1(4), CALCRL(1), CCKAR(1), CCKBR(2), CGA(1), CHRM1(3), CHRM2(3), CHRM3(4), CHRM4(3), CHRM5(4), CNR1(1), CNR2(3), CRHR2(5), CTSG(5), CYSLTR1(2), CYSLTR2(2), DRD1(1), DRD2(1), DRD3(3), DRD5(10), EDNRA(1), EDNRB(1), F2(4), F2R(2), F2RL1(4), F2RL3(3), FPR1(1), FSHR(3), GABBR1(2), GABBR2(2), GABRA2(3), GABRA3(4), GABRA4(10), GABRA5(4), GABRB1(6), GABRB3(7), GABRD(5), GABRE(5), GABRG1(7), GABRG2(6), GABRG3(2), GABRP(4), GABRQ(2), GABRR1(3), GABRR2(1), GALR1(2), GH1(2), GH2(2), GHR(4), GHRHR(3), GHSR(2), GIPR(2), GLP1R(2), GLP2R(3), GLRA1(2), GLRA2(2), GLRA3(3), GLRB(4), GNRHR(3), GPR156(2), GPR35(2), GPR50(3), GPR63(1), GPR83(4), GRIA1(7), GRIA2(2), GRIA3(9), GRIA4(4), GRID1(3), GRID2(5), GRIK1(6), GRIK2(4), GRIK3(6), GRIK4(5), GRIK5(3), GRIN1(2), GRIN2A(17), GRIN2B(9), GRIN2C(6), GRIN2D(5), GRIN3A(5), GRIN3B(2), GRM1(6), GRM2(4), GRM3(16), GRM4(6), GRM5(6), GRM6(6), GRM7(5), GRM8(7), GRPR(4), GZMA(1), HCRTR1(1), HCRTR2(3), HRH1(3), HRH2(3), HRH3(3), HRH4(2), HTR1A(2), HTR1B(2), HTR1D(3), HTR1E(3), HTR1F(3), HTR2A(2), HTR2B(2), HTR2C(4), HTR4(2), HTR5A(8), HTR6(1), HTR7(4), LEPR(3), LHCGR(2), LTB4R(1), LTB4R2(1), MC1R(3), MC2R(2), MC3R(6), MC4R(6), MC5R(5), MCHR1(2), MCHR2(3), MLNR(1), MTNR1A(2), MTNR1B(2), NMBR(6), NMUR1(4), NMUR2(6), NPBWR1(2), NPBWR2(4), NPFFR2(2), NPY1R(3), NPY2R(2), NPY5R(3), NR3C1(3), NTSR1(4), OPRD1(2), OPRL1(3), OPRM1(4), P2RX1(2), P2RX2(2), P2RX3(1), P2RX4(1), P2RX5(2), P2RX7(1), P2RY1(1), P2RY10(1), P2RY13(1), P2RY2(3), P2RY4(2), P2RY6(2), P2RY8(6), PARD3(3), PRL(1), PRLHR(1), PRLR(2), PRSS1(2), PRSS3(2), PTAFR(2), PTGER3(1), PTGER4(2), PTGFR(7), PTH2R(3), RXFP1(5), RXFP2(6), SCTR(1), SSTR2(3), SSTR3(6), SSTR5(1), TAAR1(1), TAAR2(2), TAAR5(1), TAAR6(1), TAAR8(1), TACR2(2), TACR3(7), TBXA2R(1), THRA(3), THRB(2), TRHR(2), TRPV1(4), TSHR(5), UTS2R(2), VIPR1(1), VIPR2(2) 257058057 648 340 639 246 279 100 65 146 58 0 0.0189 1.000 1.000 394 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 239 ACVR1B(3), ACVR1C(3), AKT1(2), ARRB1(2), ARRB2(1), ATF2(2), ATF4(1), BDNF(1), CACNA1A(5), CACNA1B(15), CACNA1C(7), CACNA1D(11), CACNA1E(12), CACNA1F(7), CACNA1G(7), CACNA1H(11), CACNA1I(9), CACNA1S(14), CACNA2D1(13), CACNA2D2(3), CACNA2D3(4), CACNA2D4(3), CACNB2(3), CACNB3(4), CACNB4(2), CACNG1(2), CACNG2(2), CACNG3(8), CACNG7(3), CACNG8(1), CD14(1), CDC25B(1), CHUK(1), CRKL(2), DAXX(5), DDIT3(2), DUSP1(1), DUSP10(2), DUSP14(1), DUSP16(3), DUSP4(1), DUSP5(4), DUSP7(1), DUSP9(2), EGF(10), ELK1(5), ELK4(2), FAS(1), FASLG(1), FGF13(3), FGF14(3), FGF16(2), FGF18(2), FGF4(1), FGF5(3), FGF6(1), FGF7(2), FGFR1(3), FGFR2(3), FGFR3(5), FGFR4(5), FLNA(18), FLNB(12), FLNC(16), FOS(2), GADD45B(1), GNG12(1), IKBKB(2), IL1A(1), IL1B(3), IL1R1(4), IL1R2(3), MAP2K1(1), MAP2K2(1), MAP2K3(6), MAP2K5(2), MAP3K1(9), MAP3K10(1), MAP3K12(6), MAP3K13(3), MAP3K3(2), MAP3K4(7), MAP3K5(4), MAP3K6(1), MAP3K7(3), MAP3K8(4), MAP4K1(3), MAP4K2(1), MAP4K3(5), MAP4K4(4), MAPK1(4), MAPK10(1), MAPK12(2), MAPK13(2), MAPK3(2), MAPK7(6), MAPK8(2), MAPK8IP1(3), MAPK8IP2(4), MAPK8IP3(6), MAPK9(1), MAPKAPK2(2), MAPKAPK3(2), MAPKAPK5(2), MKNK1(2), MRAS(1), NFATC2(7), NFATC4(5), NFKB1(2), NFKB2(2), NLK(1), NR4A1(3), NTF3(2), NTRK1(3), PAK1(3), PAK2(2), PDGFA(1), PDGFRB(4), PLA2G12B(1), PLA2G2D(1), PLA2G2F(1), PLA2G3(5), PLA2G4A(7), PLA2G5(1), PLA2G6(3), PPM1A(1), PPM1B(3), PPP3CA(1), PPP3CB(1), PPP3CC(1), PRKACG(1), PRKCA(6), PRKCG(4), PRKX(1), PTPN5(1), PTPN7(2), PTPRR(6), RAC1(1), RAC2(1), RAF1(2), RAPGEF2(5), RASA1(4), RASA2(3), RASGRF1(7), RASGRF2(6), RASGRP1(2), RASGRP2(3), RASGRP3(2), RASGRP4(3), RPS6KA1(5), RPS6KA2(5), RPS6KA3(4), RPS6KA5(2), RPS6KA6(5), RRAS(1), SOS1(7), SOS2(5), SRF(3), STK3(3), STMN1(1), TAOK1(3), TAOK2(5), TAOK3(2), TGFB2(2), TGFB3(1), TGFBR1(4), TGFBR2(5), TNF(1), TNFRSF1A(1), TRAF2(2), ZAK(5) 323477426 601 317 590 218 198 102 72 120 105 4 0.0948 1.000 1.000 395 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 196 ABI2(3), ACTN1(3), ACTN2(6), ACTN4(2), APC(3), APC2(3), ARAF(1), ARHGEF1(1), ARHGEF12(4), ARHGEF4(4), ARHGEF6(7), ARHGEF7(2), ARPC1A(1), ARPC1B(2), ARPC2(1), ARPC3(1), ARPC4(1), BAIAP2(3), BCAR1(3), BDKRB1(1), CD14(1), CFL1(1), CFL2(2), CHRM1(3), CHRM2(3), CHRM3(4), CHRM4(3), CHRM5(4), CRKL(2), CSK(2), CYFIP2(4), DIAPH1(5), DIAPH2(5), DIAPH3(4), DOCK1(3), EGF(10), EZR(4), F2(4), F2R(2), FGD1(1), FGD3(4), FGF13(3), FGF14(3), FGF16(2), FGF18(2), FGF4(1), FGF5(3), FGF6(1), FGF7(2), FGFR1(3), FGFR2(3), FGFR3(5), FGFR4(5), FN1(9), GIT1(2), GNA13(1), GNG12(1), GSN(2), INS(1), IQGAP1(9), IQGAP2(6), IQGAP3(4), ITGA1(4), ITGA10(5), ITGA11(3), ITGA2(5), ITGA2B(2), ITGA3(1), ITGA4(8), ITGA5(3), ITGA6(3), ITGA7(4), ITGA8(6), ITGA9(2), ITGAD(5), ITGAE(7), ITGAL(2), ITGAM(7), ITGAV(3), ITGAX(8), ITGB1(3), ITGB2(5), ITGB3(3), ITGB4(8), ITGB6(9), ITGB7(7), ITGB8(2), LIMK1(4), MAP2K1(1), MAP2K2(1), MAPK1(4), MAPK3(2), MRAS(1), MSN(2), MYH10(8), MYH14(7), MYH9(3), MYL2(2), MYL5(1), MYLK(7), MYLK2(1), NCKAP1(5), NCKAP1L(4), PAK1(3), PAK2(2), PAK3(3), PAK4(3), PAK6(3), PAK7(5), PDGFA(1), PDGFRB(4), PFN4(1), PIK3CB(7), PIK3CD(3), PIK3CG(12), PIK3R2(4), PIK3R3(2), PIK3R5(4), PIP4K2A(1), PIP4K2B(1), PIP4K2C(5), PIP5K1B(3), PIP5K1C(2), PPP1CA(1), PPP1CB(1), PPP1CC(1), PPP1R12A(1), PPP1R12B(1), PTK2(2), PXN(1), RAC1(1), RAC2(1), RAF1(2), RDX(5), ROCK1(4), ROCK2(5), RRAS(1), SCIN(2), SOS1(7), SOS2(5), SSH1(4), SSH2(2), SSH3(2), TIAM1(5), TIAM2(14), VAV1(9), VAV2(4), VAV3(3), VCL(1), WAS(3), WASF1(1), WASF2(1), WASL(2) 315735977 520 287 516 199 160 75 65 138 80 2 0.473 1.000 1.000 396 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(3), CD36(5), CD44(6), CHAD(1), COL11A1(8), COL11A2(11), COL1A1(4), COL1A2(20), COL2A1(7), COL3A1(9), COL4A1(4), COL4A2(7), COL4A4(11), COL4A6(9), COL5A1(7), COL5A2(4), COL5A3(2), COL6A1(7), COL6A2(6), COL6A3(28), COL6A6(8), DAG1(3), FN1(9), FNDC1(7), FNDC3A(5), FNDC4(1), FNDC5(1), GP5(2), GP9(1), HMMR(1), HSPG2(24), IBSP(1), ITGA1(4), ITGA10(5), ITGA11(3), ITGA2(5), ITGA2B(2), ITGA3(1), ITGA4(8), ITGA5(3), ITGA6(3), ITGA7(4), ITGA8(6), ITGA9(2), ITGAV(3), ITGB1(3), ITGB3(3), ITGB4(8), ITGB6(9), ITGB7(7), ITGB8(2), LAMA1(16), LAMA2(18), LAMA3(14), LAMA4(5), LAMA5(18), LAMB1(7), LAMB2(1), LAMB3(6), LAMB4(10), LAMC1(5), LAMC2(5), LAMC3(9), RELN(25), SDC1(2), SDC2(1), SDC3(1), SDC4(1), SPP1(2), SV2A(2), SV2B(5), SV2C(4), THBS1(6), THBS2(6), THBS3(5), THBS4(5), TNC(9), TNN(7), TNR(5), TNXB(14), VWF(14) 266533048 531 285 529 186 178 122 57 107 65 2 0.0149 1.000 1.000 397 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(5), ADCY2(7), ADCY3(5), ADCY4(6), ADCY5(8), ADCY6(2), ADCY7(3), ADCY8(3), ADCY9(11), ADRA1A(2), ADRA1B(2), ADRB2(1), ANXA6(3), ARRB1(2), ARRB2(1), ATP1A4(2), ATP1B1(1), ATP1B2(1), ATP2A2(4), ATP2A3(4), ATP2B2(8), ATP2B3(8), CACNA1A(5), CACNA1B(15), CACNA1C(7), CACNA1D(11), CACNA1E(12), CACNA1S(14), CACNB3(4), CALM1(1), CALM3(1), CALR(2), CAMK1(2), CAMK2A(3), CAMK2D(1), CAMK2G(2), CAMK4(3), CASQ1(2), CASQ2(3), CHRM1(3), CHRM2(3), CHRM3(4), CHRM4(3), CHRM5(4), GJA1(5), GJA4(1), GJB2(1), GJB3(2), GJB4(2), GJB6(2), GNA11(1), GNAI2(1), GNAI3(2), GNAO1(2), GNAZ(1), GNB1(1), GNB2(2), GNB3(1), GNB4(1), GNB5(1), GNG12(1), GNG2(1), GNG5(1), GRK4(5), GRK5(4), ITPR1(9), ITPR2(15), ITPR3(18), KCNB1(5), KCNJ3(2), KCNJ5(5), MIB1(5), MYCBP(1), NME7(2), PEA15(1), PLCB3(4), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), PRKCA(6), PRKCD(3), PRKCE(1), PRKCG(4), PRKCH(3), PRKCQ(4), PRKD1(1), RGS1(1), RGS11(1), RGS14(1), RGS18(2), RGS19(1), RGS3(11), RGS4(4), RGS6(3), RGS7(3), RGS9(4), RYR1(16), RYR2(58), RYR3(28), SFN(3), SLC8A1(3), SLC8A3(2), USP5(1), YWHAB(2), YWHAH(2), YWHAQ(1) 223287268 472 270 467 157 184 75 59 85 66 3 0.00750 1.000 1.000 398 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 248 ACVR1(3), ACVR1B(3), ACVR2A(2), AMHR2(2), BMP2(1), BMPR1A(1), BMPR1B(1), BMPR2(1), CCL1(1), CCL11(2), CCL13(1), CCL14(2), CCL16(1), CCL19(1), CCL2(1), CCL20(1), CCL24(2), CCL26(2), CCL27(1), CCL3(1), CCL5(1), CCR1(1), CCR2(2), CCR3(2), CCR4(2), CCR5(1), CCR6(3), CCR7(1), CCR8(3), CCR9(2), CD40(1), CD40LG(2), CD70(2), CLCF1(1), CNTF(1), CNTFR(2), CRLF2(3), CSF1R(5), CSF2(2), CSF2RA(9), CSF2RB(6), CSF3R(3), CX3CL1(2), CX3CR1(3), CXCL1(1), CXCL13(1), CXCL6(1), CXCL9(1), CXCR4(2), CXCR6(1), EDA(2), EDAR(7), EGF(10), EPO(2), EPOR(1), FAS(1), FASLG(1), FLT1(10), FLT3(8), FLT4(8), GDF5(2), GH1(2), GH2(2), GHR(4), HGF(4), IFNA10(2), IFNA5(1), IFNA6(1), IFNA7(1), IFNA8(1), IFNAR1(2), IFNAR2(2), IFNB1(2), IFNG(2), IFNGR1(1), IFNGR2(4), IFNK(1), IFNW1(3), IL10(1), IL10RB(1), IL12B(4), IL12RB1(4), IL12RB2(4), IL13RA1(3), IL15(2), IL15RA(1), IL17B(1), IL17RA(3), IL17RB(2), IL18(3), IL18R1(4), IL18RAP(10), IL19(1), IL1A(1), IL1B(3), IL1R1(4), IL1R2(3), IL1RAP(2), IL20(1), IL20RA(2), IL21R(3), IL22(2), IL22RA1(1), IL23A(1), IL23R(5), IL26(3), IL2RB(2), IL3(2), IL3RA(4), IL4R(10), IL5(1), IL5RA(3), IL6(2), IL6R(1), IL6ST(3), IL7(1), IL7R(3), IL9(1), IL9R(2), INHBA(1), INHBB(1), INHBE(3), KDR(14), KIT(9), KITLG(3), LEPR(3), LIFR(2), LTB(1), LTBR(2), MET(13), MPL(5), NGFR(1), OSM(1), OSMR(5), PDGFC(2), PDGFRB(4), PLEKHO2(1), PPBP(2), PRL(1), PRLR(2), RELT(4), TGFB2(2), TGFB3(1), TGFBR1(4), TGFBR2(5), TNF(1), TNFRSF10C(1), TNFRSF10D(1), TNFRSF11A(5), TNFRSF11B(2), TNFRSF13B(1), TNFRSF14(1), TNFRSF17(1), TNFRSF19(1), TNFRSF1A(1), TNFRSF1B(3), TNFRSF21(2), TNFRSF25(2), TNFRSF4(3), TNFRSF6B(1), TNFRSF8(4), TNFRSF9(4), TNFSF10(2), TNFSF11(1), TNFSF13B(1), TNFSF14(7), TNFSF15(3), TNFSF18(1), TNFSF8(3), TNFSF9(5), TPO(10), VEGFA(3), VEGFB(3), VEGFC(3), XCL1(3), XCR1(1) 204511165 466 269 460 180 144 77 60 115 70 0 0.256 1.000 1.000 399 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 123 ABL1(6), ABLIM1(3), ABLIM2(2), ABLIM3(9), ARHGEF12(4), CFL1(1), CFL2(2), CXCR4(2), DCC(12), DPYSL5(2), EFNA1(1), EFNA3(4), EFNA5(3), EFNB1(3), EFNB2(2), EFNB3(2), EPHA1(4), EPHA2(2), EPHA3(10), EPHA4(8), EPHA5(9), EPHA6(5), EPHA7(8), EPHA8(9), EPHB1(4), EPHB2(5), EPHB3(1), EPHB4(6), EPHB6(10), FES(6), FYN(2), GNAI1(4), GNAI2(1), GNAI3(2), GSK3B(1), ITGB1(3), L1CAM(12), LIMK1(4), LRRC4C(6), MAPK1(4), MAPK3(2), MET(13), NFAT5(3), NFATC1(2), NFATC2(7), NFATC3(2), NFATC4(5), NGEF(7), NRP1(5), NTN1(3), NTN4(5), NTNG1(2), PAK1(3), PAK2(2), PAK3(3), PAK4(3), PAK6(3), PAK7(5), PLXNA1(11), PLXNA2(9), PLXNA3(7), PLXNB1(6), PLXNB2(3), PLXNB3(9), PLXNC1(3), PPP3CA(1), PPP3CB(1), PPP3CC(1), PTK2(2), RAC1(1), RAC2(1), RASA1(4), RGS3(11), RHOD(1), RND1(1), ROBO1(7), ROBO2(11), ROBO3(5), ROCK1(4), ROCK2(5), SEMA3A(5), SEMA3C(12), SEMA3D(3), SEMA3F(2), SEMA4A(3), SEMA4B(1), SEMA4C(1), SEMA4D(3), SEMA4F(5), SEMA4G(3), SEMA5B(2), SEMA6A(3), SEMA6B(5), SEMA6C(2), SEMA6D(6), SEMA7A(4), SLIT1(7), SLIT2(8), SLIT3(11), SRGAP1(4), SRGAP2(3), SRGAP3(2), UNC5A(2), UNC5B(1), UNC5C(5), UNC5D(2) 231066000 468 260 463 156 135 74 67 120 71 1 0.0476 1.000 1.000 400 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 126 ACTB(2), ACTG1(1), ACTN1(3), ACTN2(6), ACTN4(2), AKT1(2), AMOTL1(5), ASH1L(5), CASK(2), CDK4(1), CGN(2), CLDN1(1), CLDN11(1), CLDN14(3), CLDN15(1), CLDN16(2), CLDN17(1), CLDN18(1), CLDN19(3), CLDN2(2), CLDN22(1), CLDN4(1), CLDN6(1), CLDN7(1), CLDN8(1), CLDN9(1), CRB3(2), CSNK2A1(2), CSNK2B(3), CTNNA1(2), CTNNA2(5), CTNNA3(5), CTNNB1(3), CTTN(3), EPB41(1), EPB41L1(2), EPB41L2(8), EPB41L3(12), EXOC3(1), EXOC4(3), F11R(2), GNAI1(4), GNAI2(1), GNAI3(2), HCLS1(4), INADL(7), JAM2(4), JAM3(2), LLGL1(5), LLGL2(3), MAGI1(6), MAGI2(6), MAGI3(6), MLLT4(10), MPDZ(12), MRAS(1), MYH1(19), MYH10(8), MYH11(14), MYH13(19), MYH14(7), MYH15(10), MYH2(25), MYH3(11), MYH6(7), MYH7(13), MYH7B(12), MYH9(3), MYL2(2), MYL5(1), OCLN(3), PARD3(3), PARD6A(1), PARD6B(4), PPM1J(4), PPP2CA(4), PPP2CB(1), PPP2R1B(2), PPP2R2A(4), PPP2R2C(3), PPP2R3A(5), PPP2R4(1), PRKCA(6), PRKCD(3), PRKCE(1), PRKCG(4), PRKCH(3), PRKCI(2), PRKCQ(4), RAB3B(1), RRAS(1), SPTAN1(8), SRC(2), SYMPK(6), TJAP1(3), TJP1(8), TJP2(1), TJP3(7), YES1(2), ZAK(5) 219082725 432 254 426 127 175 56 53 92 54 2 0.00292 1.000 1.000 401 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA2(3), ADCY1(5), ADCY2(7), ADCY3(5), ADCY4(6), ADCY5(8), ADCY6(2), ADCY7(3), ADCY8(3), ADCY9(11), ARRB1(2), ARRB2(1), ATF1(1), ATF2(2), ATF4(1), ATF5(2), ATP2A2(4), ATP2A3(4), CACNB3(4), CALCA(1), CALM1(1), CALM3(1), CAMK2A(3), CAMK2D(1), CAMK2G(2), CNN2(2), CORIN(5), DGKZ(2), FOS(2), GABPA(2), GBA2(1), GJA1(5), GNB1(1), GNB2(2), GNB3(1), GNB4(1), GNB5(1), GNG12(1), GNG2(1), GNG5(1), GRK4(5), GRK5(4), GUCY1A3(3), IGFBP2(1), IGFBP6(1), IL1B(3), IL6(2), ITPR1(9), ITPR2(15), ITPR3(18), MIB1(5), MYL2(2), MYLK2(1), NFKB1(2), NOS1(10), NOS3(10), PDE4B(2), PDE4D(6), PLCB3(4), PLCD1(4), PLCG1(12), PLCG2(12), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), PRKCA(6), PRKCD(3), PRKCE(1), PRKCH(3), PRKCQ(4), PRKD1(1), RAMP3(2), RGS1(1), RGS11(1), RGS14(1), RGS18(2), RGS19(1), RGS3(11), RGS4(4), RGS6(3), RGS7(3), RGS9(4), RLN1(1), RYR1(16), RYR2(58), RYR3(28), SFN(3), SLC8A1(3), SP1(1), TNXB(14), USP5(1), YWHAB(2), YWHAH(2), YWHAQ(1) 205983677 427 250 422 146 160 61 53 88 62 3 0.0299 1.000 1.000 402 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 130 ALCAM(2), CADM1(4), CADM3(1), CD2(1), CD22(9), CD226(1), CD274(1), CD276(2), CD28(2), CD4(2), CD40(1), CD40LG(2), CD58(2), CD6(2), CD86(3), CD8A(1), CDH1(4), CDH15(3), CDH2(2), CDH3(3), CDH4(8), CDH5(5), CLDN1(1), CLDN11(1), CLDN14(3), CLDN15(1), CLDN16(2), CLDN17(1), CLDN18(1), CLDN19(3), CLDN2(2), CLDN22(1), CLDN4(1), CLDN6(1), CLDN7(1), CLDN8(1), CLDN9(1), CNTN1(3), CNTN2(4), CNTNAP1(5), CNTNAP2(17), CTLA4(1), ESAM(1), F11R(2), GLG1(3), HLA-A(1), HLA-B(1), HLA-C(1), HLA-DMA(2), HLA-DMB(5), HLA-DOA(2), HLA-DOB(2), HLA-DPB1(1), HLA-DQA1(1), HLA-DQA2(3), HLA-DRA(4), HLA-DRB1(1), HLA-DRB5(1), HLA-E(1), HLA-F(2), ICAM1(3), ICAM2(2), ICOS(1), ICOSLG(4), ITGA4(8), ITGA6(3), ITGA8(6), ITGA9(2), ITGAL(2), ITGAM(7), ITGAV(3), ITGB1(3), ITGB2(5), ITGB7(7), ITGB8(2), JAM2(4), JAM3(2), L1CAM(12), MAG(5), MPZ(1), MPZL1(2), NCAM1(4), NEGR1(5), NEO1(9), NFASC(2), NLGN1(5), NLGN2(4), NLGN3(5), NRCAM(7), NRXN1(9), NRXN2(1), NRXN3(8), OCLN(3), PDCD1(1), PDCD1LG2(1), PTPRC(9), PTPRF(10), PTPRM(10), PVR(3), PVRL1(3), PVRL2(1), PVRL3(2), SDC1(2), SDC2(1), SDC3(1), SDC4(1), SELE(8), SELP(4), SELPLG(3), SIGLEC1(6), SPN(1), VCAM1(2), VCAN(10) 175606064 371 225 366 149 133 63 35 85 55 0 0.355 1.000 1.000 403 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 36 ACTA2(3), ACTN2(6), ACTN4(2), DES(3), DMD(23), MYBPC1(4), MYBPC2(4), MYBPC3(1), MYH3(11), MYH6(7), MYH7(13), MYL1(2), MYL2(2), MYL3(1), MYOM1(5), NEB(26), TMOD1(1), TNNC2(1), TNNI1(1), TNNT1(4), TNNT2(1), TNNT3(5), TPM1(6), TPM2(1), TPM3(3), TPM4(1), TTN(208), VIM(2) 157584525 347 202 342 98 119 52 39 101 34 2 0.0131 1.000 1.000 404 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 159 ADORA3(2), ADRA1A(2), ADRA1B(2), ADRA2A(1), ADRA2C(3), ADRB2(1), AGTR1(1), AGTR2(4), AVPR1A(6), AVPR1B(2), AVPR2(4), BDKRB1(1), BRS3(1), C3AR1(3), CCKAR(1), CCKBR(2), CCR1(1), CCR10(1), CCR2(2), CCR3(2), CCR4(2), CCR5(1), CCR6(3), CCR7(1), CCR8(3), CCR9(2), CHML(4), CHRM1(3), CHRM2(3), CHRM3(4), CHRM4(3), CHRM5(4), CMKLR1(1), CNR1(1), CNR2(3), CX3CR1(3), CXCR4(2), DRD1(1), DRD2(1), DRD3(3), DRD5(10), EDNRA(1), EDNRB(1), F2R(2), F2RL1(4), F2RL3(3), FPR1(1), FSHR(3), GALR1(2), GALT(1), GHSR(2), GNB2L1(2), GPR17(2), GPR173(1), GPR174(2), GPR27(1), GPR35(2), GPR37(5), GPR37L1(1), GPR4(3), GPR50(3), GPR6(3), GPR63(1), GPR83(4), GPR85(4), GPR87(1), GRPR(4), HCRTR1(1), HCRTR2(3), HRH1(3), HRH2(3), HRH3(3), HTR1A(2), HTR1B(2), HTR1D(3), HTR1E(3), HTR1F(3), HTR2A(2), HTR2B(2), HTR2C(4), HTR4(2), HTR5A(8), HTR6(1), HTR7(4), LHCGR(2), LTB4R(1), MC1R(3), MC3R(6), MC4R(6), MC5R(5), MLNR(1), MTNR1A(2), MTNR1B(2), NMBR(6), NMUR1(4), NMUR2(6), NPY1R(3), NPY2R(2), NPY5R(3), NTSR1(4), OPN1SW(1), OPRD1(2), OPRL1(3), OPRM1(4), OR10A5(2), OR11A1(1), OR1C1(4), OR1F1(2), OR1Q1(1), OR2H1(3), OR5V1(3), OR7A5(1), OR7C1(2), P2RY1(1), P2RY10(1), P2RY12(2), P2RY13(1), P2RY2(3), P2RY6(2), PTAFR(2), PTGER4(2), PTGFR(7), RGR(2), RRH(1), SSTR2(3), SSTR3(6), SUCNR1(3), TBXA2R(1), TRHR(2) 142679859 332 201 327 133 159 47 36 68 22 0 0.0546 1.000 1.000 405 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADA(1), ADCY1(5), ADCY2(7), ADCY3(5), ADCY4(6), ADCY5(8), ADCY6(2), ADCY7(3), ADCY8(3), ADCY9(11), ADK(1), ADSL(4), ADSSL1(1), AK1(1), AK5(3), AK7(9), ALLC(6), AMPD1(8), AMPD2(4), AMPD3(2), ATIC(1), CANT1(4), DCK(2), ENPP1(5), ENPP3(2), ENTPD1(4), ENTPD5(1), ENTPD6(2), ENTPD8(1), FHIT(1), GART(4), GDA(2), GMPR(1), GMPR2(3), GUCY1A2(2), GUCY1A3(3), GUCY1B3(1), GUCY2C(5), GUCY2D(1), GUCY2F(4), HPRT1(1), IMPDH1(5), NME7(2), NPR1(2), NPR2(3), NT5C(3), NT5C1A(1), NT5C1B(7), NT5C2(1), NT5E(3), NT5M(1), NUDT2(1), PAICS(2), PDE10A(2), PDE11A(6), PDE1A(3), PDE1C(9), PDE2A(5), PDE3B(3), PDE4A(3), PDE4B(2), PDE4C(1), PDE4D(6), PDE5A(1), PDE7A(2), PDE7B(2), PDE8A(7), PDE8B(2), PDE9A(2), PFAS(7), PKLR(4), PNPT1(1), POLA1(3), POLA2(2), POLD1(3), POLD2(2), POLD3(2), POLD4(1), POLE(8), POLE2(1), POLR1A(7), POLR1B(3), POLR2A(9), POLR2B(4), POLR2C(2), POLR2G(1), POLR3A(7), POLR3B(3), POLR3G(1), POLR3GL(1), POLR3K(1), PPAT(2), PRIM1(2), PRIM2(1), PRPS1(1), PRPS1L1(3), PRPS2(5), RRM1(3), RRM2(1), RRM2B(1), XDH(11) 194199771 330 199 328 107 108 63 35 76 48 0 0.0374 1.000 1.000 406 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 147 AKT1(2), CBL(2), CBLB(3), CBLC(2), CCND1(4), CCND2(2), CCND3(1), CISH(1), CLCF1(1), CNTF(1), CNTFR(2), CREBBP(13), CRLF2(3), CSF2(2), CSF2RA(9), CSF2RB(6), CSF3R(3), EP300(6), EPO(2), EPOR(1), GH1(2), GH2(2), GHR(4), IFNA10(2), IFNA5(1), IFNA6(1), IFNA7(1), IFNA8(1), IFNAR1(2), IFNAR2(2), IFNB1(2), IFNG(2), IFNGR1(1), IFNGR2(4), IFNK(1), IFNW1(3), IL10(1), IL10RB(1), IL12B(4), IL12RB1(4), IL12RB2(4), IL13RA1(3), IL13RA2(1), IL15(2), IL15RA(1), IL19(1), IL20(1), IL20RA(2), IL21R(3), IL22(2), IL22RA1(1), IL23A(1), IL23R(5), IL26(3), IL2RB(2), IL3(2), IL3RA(4), IL4R(10), IL5(1), IL5RA(3), IL6(2), IL6R(1), IL6ST(3), IL7(1), IL7R(3), IL9(1), IL9R(2), IRF9(4), JAK1(3), JAK2(5), JAK3(5), LEPR(3), LIFR(2), MPL(5), OSM(1), OSMR(5), PIAS1(2), PIAS3(3), PIAS4(3), PIK3CB(7), PIK3CD(3), PIK3CG(12), PIK3R2(4), PIK3R3(2), PIK3R5(4), PIM1(3), PRL(1), PRLR(2), PTPN6(1), SOCS1(1), SOCS4(3), SOCS5(2), SOS1(7), SOS2(5), SPRED1(1), SPRED2(3), SPRY1(1), SPRY2(3), SPRY3(3), SPRY4(3), STAM(2), STAM2(2), STAT1(4), STAT2(2), STAT3(3), STAT4(4), STAT5A(1), STAT5B(2), STAT6(5), TPO(10), TYK2(10) 166227050 329 195 328 105 93 48 42 98 47 1 0.0727 1.000 1.000 407 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 126 ACACA(17), ACACB(18), AKT1(2), ARAF(1), CALM1(1), CALM3(1), CALML3(1), CALML6(1), CBL(2), CBLB(3), CBLC(2), CRKL(2), ELK1(5), EXOC7(3), FASN(3), FBP1(3), FBP2(2), FLOT1(1), FLOT2(3), FOXO1(1), G6PC(8), G6PC2(1), GCK(2), GSK3B(1), GYS1(1), GYS2(2), IKBKB(2), INPP5D(5), INS(1), INSR(6), IRS1(8), IRS2(1), IRS4(7), LIPE(3), MAP2K1(1), MAP2K2(1), MAPK1(4), MAPK10(1), MAPK3(2), MAPK8(2), MAPK9(1), MKNK1(2), PCK1(6), PDE3A(5), PDE3B(3), PFKL(5), PFKP(1), PHKA1(5), PHKA2(5), PHKB(1), PHKG1(3), PIK3CB(7), PIK3CD(3), PIK3CG(12), PIK3R2(4), PIK3R3(2), PIK3R5(4), PKLR(4), PPARGC1A(1), PPP1CA(1), PPP1CB(1), PPP1CC(1), PPP1R3A(13), PPP1R3C(1), PRKAA1(3), PRKAA2(2), PRKACG(1), PRKAG1(1), PRKAG2(2), PRKAG3(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), PRKCI(2), PRKX(1), PTPN1(1), PTPRF(10), PYGB(3), PYGL(6), PYGM(2), RAF1(2), RAPGEF1(4), RHOQ(1), RPS6KB1(2), RPS6KB2(3), SH2B2(2), SHC1(1), SHC2(1), SHC3(1), SHC4(2), SLC2A4(2), SOCS1(1), SOCS4(3), SORBS1(3), SOS1(7), SOS2(5), SREBF1(7), TRIP10(1), TSC1(2), TSC2(6) 183484689 317 193 317 114 97 51 34 88 44 3 0.212 1.000 1.000 408 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 88 ADCY1(5), ADCY2(7), ADCY3(5), ADCY4(6), ADCY5(8), ADCY6(2), ADCY7(3), ADCY8(3), ADCY9(11), CSNK1D(2), DRD1(1), DRD2(1), EGF(10), GJA1(5), GJD2(3), GNA11(1), GNAI1(4), GNAI2(1), GNAI3(2), GNAS(4), GRM1(6), GRM5(6), GUCY1A2(2), GUCY1A3(3), GUCY1B3(1), GUCY2C(5), GUCY2D(1), GUCY2F(4), HTR2A(2), HTR2B(2), HTR2C(4), ITPR1(9), ITPR2(15), ITPR3(18), MAP2K1(1), MAP2K2(1), MAP2K5(2), MAPK1(4), MAPK3(2), MAPK7(6), NPR1(2), NPR2(3), PDGFA(1), PDGFC(2), PDGFD(4), PDGFRB(4), PLCB1(4), PLCB2(7), PLCB3(4), PLCB4(4), PRKACG(1), PRKCA(6), PRKCG(4), PRKG1(2), PRKG2(6), PRKX(1), RAF1(2), SOS1(7), SOS2(5), SRC(2), TJP1(8), TUBA1A(3), TUBA1B(1), TUBA3C(11), TUBA3D(2), TUBA4A(2), TUBA8(2), TUBB(1), TUBB6(3), TUBB8(3) 150492585 285 189 284 100 108 42 32 54 46 3 0.123 1.000 1.000 409 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 142 APC(3), APC2(3), AXIN1(4), AXIN2(2), BTRC(2), CAMK2A(3), CAMK2D(1), CAMK2G(2), CCND1(4), CCND2(2), CCND3(1), CHD8(11), CREBBP(13), CSNK1A1(2), CSNK1A1L(2), CSNK1E(1), CSNK2A1(2), CSNK2B(3), CTBP1(5), CTBP2(4), CTNNB1(3), CUL1(4), CXXC4(2), DAAM1(1), DAAM2(3), DKK1(2), DKK2(5), DKK4(2), DVL1(1), DVL2(3), DVL3(3), EP300(6), FBXW11(1), FZD1(3), FZD10(5), FZD4(1), FZD5(1), FZD6(2), FZD7(2), FZD8(2), FZD9(4), GSK3B(1), LEF1(1), LRP5(7), LRP6(9), MAP3K7(3), MAPK10(1), MAPK8(2), MAPK9(1), MMP7(2), NFAT5(3), NFATC1(2), NFATC2(7), NFATC3(2), NFATC4(5), NKD1(2), NKD2(4), NLK(1), PLCB1(4), PLCB2(7), PLCB3(4), PLCB4(4), PORCN(8), PPP2CA(4), PPP2CB(1), PPP2R1B(2), PPP2R2A(4), PPP2R2C(3), PPP3CA(1), PPP3CB(1), PPP3CC(1), PRICKLE1(2), PRICKLE2(4), PRKACG(1), PRKCA(6), PRKCG(4), PRKX(1), PSEN1(1), RAC1(1), RAC2(1), RBX1(1), ROCK1(4), ROCK2(5), RUVBL1(2), SENP2(3), SFRP1(1), SFRP2(2), SFRP4(1), SIAH1(3), SMAD2(3), SMAD3(3), SMAD4(1), SOX17(4), TBL1X(1), TBL1XR1(3), TBL1Y(1), TCF7L2(5), VANGL1(2), VANGL2(2), WIF1(3), WNT1(1), WNT10A(2), WNT11(5), WNT16(2), WNT2B(2), WNT3(1), WNT3A(1), WNT5B(2), WNT7A(2), WNT8A(2), WNT8B(1), WNT9A(2), WNT9B(2) 190586815 319 184 317 101 103 44 38 70 63 1 0.0572 1.000 1.000 410 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 92 ADCY1(5), ADCY2(7), ADCY3(5), ADCY4(6), ADCY5(8), ADCY6(2), ADCY7(3), ADCY8(3), ADCY9(11), ATF4(1), CACNA1C(7), CACNA1D(11), CACNA1F(7), CACNA1S(14), CALM1(1), CALM3(1), CALML3(1), CALML6(1), CAMK2A(3), CAMK2D(1), CAMK2G(2), CGA(1), ELK1(5), GNA11(1), GNAS(4), GNRHR(3), HBEGF(1), ITPR1(9), ITPR2(15), ITPR3(18), MAP2K1(1), MAP2K2(1), MAP2K3(6), MAP3K1(9), MAP3K3(2), MAP3K4(7), MAPK1(4), MAPK10(1), MAPK12(2), MAPK13(2), MAPK3(2), MAPK7(6), MAPK8(2), MAPK9(1), PLA2G12B(1), PLA2G2D(1), PLA2G2F(1), PLA2G3(5), PLA2G4A(7), PLA2G5(1), PLA2G6(3), PLCB1(4), PLCB2(7), PLCB3(4), PLCB4(4), PLD1(8), PRKACG(1), PRKCA(6), PRKCD(3), PRKX(1), PTK2B(5), RAF1(2), SOS1(7), SOS2(5), SRC(2) 147472399 281 180 277 94 109 47 33 51 38 3 0.0294 1.000 1.000 411 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 107 ACTN1(3), ACTN2(6), ACTN4(2), ARHGAP5(5), BCAR1(3), CDH5(5), CLDN1(1), CLDN11(1), CLDN14(3), CLDN15(1), CLDN16(2), CLDN17(1), CLDN18(1), CLDN19(3), CLDN2(2), CLDN22(1), CLDN4(1), CLDN6(1), CLDN7(1), CLDN8(1), CLDN9(1), CTNNA1(2), CTNNA2(5), CTNNA3(5), CTNNB1(3), CTNND1(1), CXCR4(2), CYBA(1), CYBB(2), ESAM(1), EZR(4), F11R(2), GNAI1(4), GNAI2(1), GNAI3(2), ICAM1(3), ITGA4(8), ITGAL(2), ITGAM(7), ITGB1(3), ITGB2(5), ITK(1), JAM2(4), JAM3(2), MAPK12(2), MAPK13(2), MLLT4(10), MMP9(4), MSN(2), MYL2(2), MYL5(1), NCF1(3), NCF2(6), NCF4(1), NOX1(1), NOX3(5), OCLN(3), PIK3CB(7), PIK3CD(3), PIK3CG(12), PIK3R2(4), PIK3R3(2), PIK3R5(4), PLCG1(12), PLCG2(12), PRKCA(6), PRKCG(4), PTK2(2), PTK2B(5), PXN(1), RAC1(1), RAC2(1), RAPGEF3(2), RAPGEF4(3), RASSF5(1), RHOH(1), ROCK1(4), ROCK2(5), SIPA1(3), TXK(2), VASP(1), VAV1(9), VAV2(4), VAV3(3), VCAM1(2), VCL(1) 141884777 274 179 271 121 102 37 31 66 37 1 0.798 1.000 1.000 412 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 70 CALM1(1), CALM3(1), CALML3(1), CALML6(1), CDS2(2), DGKA(4), DGKB(3), DGKD(8), DGKE(3), DGKG(4), DGKH(4), DGKI(2), DGKQ(3), DGKZ(2), INPP1(1), INPP4A(1), INPP4B(5), INPP5A(1), INPP5B(4), INPP5D(5), INPP5E(1), INPPL1(8), ITPK1(3), ITPR1(9), ITPR2(15), ITPR3(18), OCRL(7), PI4KA(8), PI4KB(4), PIK3C2A(5), PIK3C2B(3), PIK3C2G(10), PIK3C3(2), PIK3CB(7), PIK3CD(3), PIK3CG(12), PIK3R2(4), PIK3R3(2), PIK3R5(4), PIP4K2A(1), PIP4K2B(1), PIP4K2C(5), PIP5K1B(3), PIP5K1C(2), PLCB1(4), PLCB2(7), PLCB3(4), PLCB4(4), PLCD1(4), PLCD3(2), PLCE1(10), PLCG1(12), PLCG2(12), PLCZ1(5), PRKCA(6), PRKCG(4), PTPMT1(1), SYNJ1(6), SYNJ2(11) 142870190 285 178 283 85 96 49 31 67 40 2 0.0143 1.000 1.000 413 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 79 AGL(6), AMY2B(6), ASCC3(7), ATP13A2(3), DDX18(1), DDX19A(2), DDX23(3), DDX4(5), DDX41(5), DDX47(2), DDX51(3), DDX52(2), DDX54(2), DDX55(1), DDX56(4), DHX58(2), ENPP1(5), ENPP3(2), ENTPD7(2), EP400(9), ERCC2(3), ERCC3(2), G6PC(8), G6PC2(1), GAA(6), GANC(5), GBE1(1), GCK(2), GPI(2), GUSB(3), GYS1(1), GYS2(2), HK1(4), HK2(5), HK3(5), IFIH1(3), LYZL1(1), MGAM(13), MOV10L1(7), PGM1(1), PGM3(1), PYGB(3), PYGL(6), PYGM(2), RAD54B(5), RAD54L(6), RUVBL2(4), SETX(5), SI(11), SKIV2L2(3), SMARCA2(5), SMARCA5(3), UGDH(1), UGP2(1), UGT1A1(5), UGT1A10(2), UGT1A3(3), UGT1A4(1), UGT1A5(3), UGT1A6(4), UGT1A7(3), UGT1A9(2), UGT2A1(9), UGT2B10(4), UGT2B11(5), UGT2B15(3), UGT2B17(2), UGT2B28(8), UGT2B4(9), UGT2B7(4), UXS1(4) 145792521 274 173 272 78 93 42 31 73 35 0 0.0228 1.000 1.000 414 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 66 A2M(7), BDKRB1(1), C1QA(2), C1QB(1), C1QC(1), C1R(2), C1S(5), C2(7), C3(19), C3AR1(3), C4BPA(6), C4BPB(2), C5(7), C5AR1(4), C6(4), C7(5), C8A(4), C8B(7), C9(2), CD46(5), CD55(2), CD59(1), CFB(2), CFD(1), CFH(10), CFI(1), CPB2(1), CR1(5), CR2(8), F10(2), F12(1), F13A1(5), F13B(5), F2(4), F2R(2), F5(13), F7(2), F8(24), FGA(12), FGB(4), FGG(6), KLKB1(7), KNG1(4), MASP1(2), MASP2(1), MBL2(4), PLAT(3), PLG(6), PROS1(3), SERPINA1(2), SERPINA5(2), SERPINC1(2), SERPIND1(1), SERPINE1(4), SERPINF2(1), SERPING1(4), VWF(14) 106427242 265 171 263 78 83 49 32 65 36 0 0.00733 1.000 1.000 415 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 106 ABL1(6), ANAPC1(3), ANAPC10(1), ANAPC2(2), ANAPC4(2), ANAPC5(4), ANAPC7(2), ATM(12), ATR(10), BUB1(5), BUB1B(2), BUB3(3), CCNA1(3), CCNA2(1), CCNB1(2), CCNB2(1), CCNB3(6), CCND1(4), CCND2(2), CCND3(1), CCNE1(2), CCNE2(2), CCNH(2), CDC14A(2), CDC14B(5), CDC16(2), CDC20(1), CDC23(4), CDC25A(1), CDC25B(1), CDC27(5), CDC6(1), CDC7(2), CDK2(1), CDK4(1), CDK7(1), CDKN1A(2), CDKN1B(4), CDKN2A(6), CDKN2B(2), CHEK1(6), CHEK2(3), CREBBP(13), CUL1(4), DBF4(6), E2F1(1), E2F2(1), E2F3(1), EP300(6), ESPL1(8), FZR1(4), GADD45B(1), GSK3B(1), HDAC2(7), MAD1L1(1), MCM2(1), MCM3(3), MCM4(5), MCM5(3), MCM6(6), MCM7(6), MDM2(5), PKMYT1(1), PLK1(2), PRKDC(14), RBL1(6), RBL2(3), RBX1(1), SFN(3), SKP2(3), SMAD2(3), SMAD3(3), SMAD4(1), SMC1A(11), SMC1B(9), TFDP1(1), TGFB2(2), TGFB3(1), WEE1(2), YWHAB(2), YWHAE(3), YWHAG(1), YWHAH(2), YWHAQ(1), YWHAZ(1) 158139080 287 168 286 77 44 54 44 86 56 3 0.0269 1.000 1.000 416 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 81 ACVR1(3), ACVR1B(3), ACVRL1(6), AKT1(2), AURKB(1), BMPR1A(1), BMPR2(1), BUB1(5), CDKL1(2), CDKL2(2), CDS2(2), CLK1(2), CLK2(1), CLK4(2), CSNK2A1(2), CSNK2B(3), DGKA(4), DGKB(3), DGKD(8), DGKE(3), DGKG(4), DGKH(4), DGKQ(3), DGKZ(2), INPP1(1), INPP4A(1), INPP4B(5), INPP5A(1), INPPL1(8), MAP3K10(1), NEK1(4), NEK3(4), OCRL(7), PAK4(3), PIK3C2A(5), PIK3C2B(3), PIK3C2G(10), PIK3CB(7), PIK3CG(12), PIM2(4), PLCB1(4), PLCB2(7), PLCB3(4), PLCB4(4), PLCD1(4), PLCG1(12), PLCG2(12), PLK3(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), PRKCA(6), PRKCD(3), PRKCE(1), PRKCG(4), PRKCH(3), PRKCQ(4), PRKD1(1), PRKG1(2), RAF1(2), RPS6KA1(5), RPS6KA2(5), RPS6KA3(4), RPS6KB1(2), STK11(1), TGFBR1(4), VRK1(3) 131619165 249 167 246 80 76 41 33 55 41 3 0.124 1.000 1.000 417 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 119 ARAF(1), CD244(2), CSF2(2), FAS(1), FASLG(1), FCGR3A(1), FYN(2), GZMB(3), HLA-A(1), HLA-B(1), HLA-C(1), HLA-E(1), ICAM1(3), ICAM2(2), IFNA10(2), IFNA5(1), IFNA6(1), IFNA7(1), IFNA8(1), IFNAR1(2), IFNAR2(2), IFNB1(2), IFNG(2), IFNGR1(1), IFNGR2(4), ITGAL(2), ITGB2(5), KIR2DL3(3), KIR3DL1(3), KIR3DL2(1), KLRC1(3), KLRC2(1), KLRC3(4), KLRD1(1), KLRK1(1), LAT(2), LCK(1), LCP2(1), MAP2K1(1), MAP2K2(1), MAPK1(4), MAPK3(2), MICA(4), MICB(2), NCR1(3), NFAT5(3), NFATC1(2), NFATC2(7), NFATC3(2), NFATC4(5), PAK1(3), PIK3CB(7), PIK3CD(3), PIK3CG(12), PIK3R2(4), PIK3R3(2), PIK3R5(4), PLCG1(12), PLCG2(12), PPP3CA(1), PPP3CB(1), PPP3CC(1), PRF1(3), PRKCA(6), PRKCG(4), PTK2B(5), PTPN6(1), RAC1(1), RAC2(1), RAF1(2), SH2D1A(3), SH2D1B(3), SH3BP2(1), SHC1(1), SHC2(1), SHC3(1), SHC4(2), SOS1(7), SOS2(5), TNF(1), TNFRSF10C(1), TNFRSF10D(1), TNFSF10(2), ULBP1(2), ULBP3(4), VAV1(9), VAV2(4), VAV3(3), ZAP70(8) 125709246 249 165 246 96 68 38 31 66 44 2 0.399 1.000 1.000 418 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 71 ARAF(1), CACNA1A(5), GNA11(1), GNA13(1), GNAI1(4), GNAI2(1), GNAI3(2), GNAO1(2), GNAS(4), GNAZ(1), GRIA1(7), GRIA2(2), GRIA3(9), GRID2(5), GRM1(6), GRM5(6), GUCY1A2(2), GUCY1A3(3), GUCY1B3(1), GUCY2C(5), GUCY2D(1), GUCY2F(4), IGF1(3), IGF1R(10), ITPR1(9), ITPR2(15), ITPR3(18), LYN(2), MAP2K1(1), MAP2K2(1), MAPK1(4), MAPK3(2), NOS1(10), NOS3(10), NPR1(2), NPR2(3), PLA2G12B(1), PLA2G2D(1), PLA2G2F(1), PLA2G3(5), PLA2G4A(7), PLA2G5(1), PLA2G6(3), PLCB1(4), PLCB2(7), PLCB3(4), PLCB4(4), PPP2CA(4), PPP2CB(1), PPP2R1B(2), PPP2R2A(4), PPP2R2C(3), PRKCA(6), PRKCG(4), PRKG1(2), PRKG2(6), RAF1(2), RYR1(16) 128385627 251 162 251 86 77 38 37 53 43 3 0.145 1.000 1.000 419 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 95 ADCY1(5), ADCY2(7), ADCY3(5), ADCY4(6), ADCY5(8), ADCY6(2), ADCY7(3), ADCY8(3), ADCY9(11), ASIP(1), CALM1(1), CALM3(1), CALML3(1), CALML6(1), CAMK2A(3), CAMK2D(1), CAMK2G(2), CREB1(2), CREB3L1(2), CREB3L2(1), CREB3L3(3), CREB3L4(1), CREBBP(13), CTNNB1(3), DCT(1), DVL1(1), DVL2(3), DVL3(3), EDNRB(1), EP300(6), FZD1(3), FZD10(5), FZD4(1), FZD5(1), FZD6(2), FZD7(2), FZD8(2), FZD9(4), GNAI1(4), GNAI2(1), GNAI3(2), GNAO1(2), GNAS(4), GSK3B(1), KIT(9), KITLG(3), LEF1(1), MAP2K1(1), MAP2K2(1), MAPK1(4), MAPK3(2), MC1R(3), PLCB1(4), PLCB2(7), PLCB3(4), PLCB4(4), PRKACG(1), PRKCA(6), PRKCG(4), PRKX(1), RAF1(2), TCF7L2(5), TYR(5), WNT1(1), WNT10A(2), WNT11(5), WNT16(2), WNT2B(2), WNT3(1), WNT3A(1), WNT5B(2), WNT7A(2), WNT8A(2), WNT8B(1), WNT9A(2), WNT9B(2) 126479547 227 159 227 74 86 27 29 45 38 2 0.0813 1.000 1.000 420 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(7), ABCA10(5), ABCA12(5), ABCA13(22), ABCA2(4), ABCA3(5), ABCA4(10), ABCA5(7), ABCA6(9), ABCA7(11), ABCA8(5), ABCA9(6), ABCB1(15), ABCB10(3), ABCB11(3), ABCB4(12), ABCB5(9), ABCB6(1), ABCB7(6), ABCB8(2), ABCB9(4), ABCC1(6), ABCC10(13), ABCC11(8), ABCC12(4), ABCC2(1), ABCC3(6), ABCC4(8), ABCC5(6), ABCC6(2), ABCC8(7), ABCC9(20), ABCD1(3), ABCD2(5), ABCD3(2), ABCG1(3), ABCG2(3), ABCG4(4), ABCG5(4), ABCG8(5), CFTR(6), TAP1(2), TAP2(1) 140615356 270 158 267 98 82 40 39 75 31 3 0.250 1.000 1.000 421 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 74 ACP1(1), ACTB(2), ACTG1(1), ACTN1(3), ACTN2(6), ACTN4(2), ACVR1B(3), ACVR1C(3), BAIAP2(3), CDH1(4), CREBBP(13), CSNK2A1(2), CSNK2B(3), CTNNA1(2), CTNNA2(5), CTNNA3(5), CTNNB1(3), CTNND1(1), EP300(6), ERBB2(3), FARP2(2), FER(1), FGFR1(3), FYN(2), IGF1R(10), INSR(6), IQGAP1(9), LEF1(1), LMO7(8), MAP3K7(3), MAPK1(4), MAPK3(2), MET(13), MLLT4(10), NLK(1), PARD3(3), PTPN1(1), PTPN6(1), PTPRB(9), PTPRF(10), PTPRJ(5), PTPRM(10), PVRL1(3), PVRL2(1), PVRL3(2), PVRL4(4), RAC1(1), RAC2(1), SMAD2(3), SMAD3(3), SMAD4(1), SNAI2(2), SORBS1(3), SRC(2), SSX2IP(1), TCF7L2(5), TGFBR1(4), TGFBR2(5), TJP1(8), VCL(1), WAS(3), WASF1(1), WASF2(1), WASF3(4), WASL(2), YES1(2) 139055184 248 156 248 75 74 32 33 63 45 1 0.0393 1.000 1.000 422 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADA(1), ADCY1(5), ADCY2(7), ADCY3(5), ADCY4(6), ADCY5(8), ADCY6(2), ADCY7(3), ADCY8(3), ADK(1), ADSL(4), AK1(1), AK5(3), ALLC(6), AMPD1(8), AMPD2(4), AMPD3(2), ATIC(1), ATP1B1(1), ATP5A1(1), ATP5B(3), ATP5G2(1), ATP5I(1), CANT1(4), DCK(2), ENPP1(5), ENPP3(2), ENTPD1(4), FHIT(1), GART(4), GDA(2), GUCY1A2(2), GUCY1A3(3), GUCY1B3(1), GUCY2C(5), GUCY2D(1), GUCY2F(4), HPRT1(1), IMPDH1(5), NPR1(2), NPR2(3), NT5C(3), NT5E(3), NT5M(1), NUDT2(1), PAICS(2), PDE1A(3), PDE4A(3), PDE4B(2), PDE4C(1), PDE4D(6), PDE5A(1), PDE6B(5), PDE6C(7), PDE7B(2), PDE8A(7), PDE9A(2), PFAS(7), PKLR(4), POLB(3), POLD1(3), POLD2(2), POLE(8), POLG(1), POLL(2), POLQ(7), POLR1B(3), POLR2A(9), POLR2B(4), POLR2C(2), POLR2G(1), POLRMT(3), PPAT(2), PRPS1(1), PRPS1L1(3), PRPS2(5), RRM1(3), RRM2(1) 152547429 251 156 251 93 86 48 23 60 34 0 0.332 1.000 1.000 423 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 90 ADCY1(5), ADCY2(7), ADCY3(5), ADCY4(6), ADCY5(8), ADCY6(2), ADCY7(3), ADCY8(3), ADCY9(11), AKAP1(2), AKAP11(3), AKAP12(1), AKAP2(6), AKAP3(2), AKAP4(8), AKAP5(3), AKAP6(12), AKAP7(1), AKAP8(5), AKAP9(15), ARHGEF1(1), CALM1(1), CALM3(1), GNA11(1), GNA13(1), GNA14(3), GNA15(1), GNAI2(1), GNAI3(2), GNAL(1), GNAO1(2), GNAZ(1), GNB1(1), GNB2(2), GNB3(1), GNB5(1), GNG12(1), GNG5(1), GNGT2(1), ITPR1(9), KCNJ3(2), PALM2(2), PDE1A(3), PDE1B(2), PDE1C(9), PDE4A(3), PDE4B(2), PDE4C(1), PDE4D(6), PDE7A(2), PDE7B(2), PDE8A(7), PDE8B(2), PLCB3(4), PPP3CA(1), PPP3CC(1), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), PRKCA(6), PRKCD(3), PRKCE(1), PRKCG(4), PRKCH(3), PRKCI(2), PRKCQ(4), PRKD1(1), PRKD3(2), RRAS(1), USP5(1) 138082122 223 152 222 80 71 38 23 46 43 2 0.254 1.000 1.000 424 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(2), BCAR1(3), CAPN1(2), CAPN10(4), CAPN11(6), CAPN3(3), CAPN5(2), CAPN6(3), CAPN7(1), CAPN9(4), CAPNS1(2), CAV3(1), CSK(2), DOCK1(3), FYN(2), ILK(1), ITGA10(5), ITGA11(3), ITGA2(5), ITGA2B(2), ITGA3(1), ITGA4(8), ITGA5(3), ITGA6(3), ITGA7(4), ITGA8(6), ITGA9(2), ITGAD(5), ITGAE(7), ITGAL(2), ITGAM(7), ITGAV(3), ITGAX(8), ITGB1(3), ITGB2(5), ITGB3(3), ITGB4(8), ITGB6(9), ITGB7(7), ITGB8(2), MAP2K1(1), MAP2K2(1), MAP2K3(6), MAPK10(1), MAPK12(2), MAPK4(2), MAPK7(6), MYLK2(1), PAK1(3), PAK2(2), PAK3(3), PAK4(3), PAK6(3), PIK3R2(4), PTK2(2), PXN(1), RAC1(1), RAC2(1), RAPGEF1(4), ROCK1(4), ROCK2(5), SDCCAG8(4), SHC1(1), SHC3(1), SORBS1(3), SOS1(7), SRC(2), TLN1(5), TNS1(6), VASP(1), VAV2(4), VAV3(3), VCL(1), ZYX(2) 159327918 248 152 247 89 84 35 30 63 36 0 0.247 1.000 1.000 425 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 83 ANPEP(5), CD14(1), CD19(2), CD1A(3), CD1B(5), CD1D(4), CD1E(5), CD2(1), CD22(9), CD33(6), CD36(5), CD37(1), CD38(1), CD3D(1), CD3E(2), CD3G(1), CD4(2), CD44(6), CD5(2), CD55(2), CD59(1), CD7(3), CD8A(1), CR1(5), CR2(8), CSF1R(5), CSF2(2), CSF2RA(9), CSF3R(3), DNTT(3), EPO(2), EPOR(1), FCER2(1), FCGR1A(1), FLT3(8), GP5(2), GP9(1), HLA-DRA(4), HLA-DRB1(1), HLA-DRB5(1), IL1A(1), IL1B(3), IL1R1(4), IL1R2(3), IL3(2), IL3RA(4), IL4R(10), IL5(1), IL5RA(3), IL6(2), IL6R(1), IL7(1), IL7R(3), IL9R(2), ITGA1(4), ITGA2(5), ITGA2B(2), ITGA3(1), ITGA4(8), ITGA5(3), ITGA6(3), ITGAM(7), ITGB3(3), KIT(9), KITLG(3), MME(3), MS4A1(3), TFRC(2), THPO(2), TNF(1), TPO(10) 96874832 235 148 234 78 78 40 26 53 38 0 0.0463 1.000 1.000 426 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 108 ALG1(1), ALG10B(3), ALG12(2), ALG13(4), ALG14(1), ALG3(4), ALG6(3), B3GNT2(1), B3GNT7(2), B4GALT2(1), C1GALT1(1), CHPF(1), CHST1(2), CHST11(3), CHST13(3), CHST2(2), CHST3(3), CHST4(2), CHST6(2), CHSY1(4), DAD1(1), DPAGT1(2), EXT1(3), EXT2(3), EXTL1(4), EXTL2(2), EXTL3(1), FUT8(7), GALNT1(6), GALNT10(1), GALNT11(3), GALNT12(3), GALNT13(4), GALNT14(7), GALNT2(3), GALNT3(1), GALNT4(3), GALNT5(5), GALNT6(4), GALNT7(1), GALNT8(1), GALNT9(4), GALNTL5(1), GANAB(4), GCNT1(2), GCNT3(2), GCNT4(3), HS3ST1(3), HS3ST3A1(3), HS6ST2(4), HS6ST3(1), MAN1A1(3), MAN1A2(1), MAN1B1(1), MAN1C1(2), MAN2A1(4), MGAT1(3), MGAT2(3), MGAT3(3), MGAT4A(1), MGAT5(2), MGAT5B(2), NDST1(2), NDST2(2), NDST3(4), NDST4(8), OGT(9), RPN1(1), RPN2(1), ST3GAL1(3), ST3GAL2(1), ST3GAL3(2), ST3GAL4(3), ST6GAL1(2), ST6GALNAC1(2), STT3B(2), UST(1), WBSCR17(11), XYLT1(3), XYLT2(3) 131029842 222 147 220 71 79 38 26 46 33 0 0.0679 1.000 1.000 427 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 64 ADCY1(5), ADCY8(3), ARAF(1), ATF4(1), CACNA1C(7), CALM1(1), CALM3(1), CALML3(1), CALML6(1), CAMK2A(3), CAMK2D(1), CAMK2G(2), CAMK4(3), CREBBP(13), EP300(6), GRIA1(7), GRIA2(2), GRIN1(2), GRIN2A(17), GRIN2B(9), GRIN2C(6), GRIN2D(5), GRM1(6), GRM5(6), ITPR1(9), ITPR2(15), ITPR3(18), MAP2K1(1), MAP2K2(1), MAPK1(4), MAPK3(2), PLCB1(4), PLCB2(7), PLCB3(4), PLCB4(4), PPP1CA(1), PPP1CB(1), PPP1CC(1), PPP1R12A(1), PPP3CA(1), PPP3CB(1), PPP3CC(1), PRKACG(1), PRKCA(6), PRKCG(4), PRKX(1), RAF1(2), RAPGEF3(2), RPS6KA1(5), RPS6KA2(5), RPS6KA3(4), RPS6KA6(5) 115777425 220 147 220 65 83 26 26 53 29 3 0.0154 1.000 1.000 428 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 75 ABL1(6), ACTN1(3), ACTR2(2), ACTR3(1), AKT1(2), ANGPTL2(3), ARHGEF6(7), ARHGEF7(2), BCAR1(3), CDKN2A(6), CSE1L(1), DOCK1(3), EPHB2(5), FYN(2), GRB7(6), ILK(1), ITGA1(4), ITGA10(5), ITGA11(3), ITGA2(5), ITGA3(1), ITGA4(8), ITGA5(3), ITGA6(3), ITGA7(4), ITGA8(6), ITGA9(2), MAPK1(4), MAPK10(1), MAPK8(2), MAPK8IP1(3), MAPK8IP2(4), MAPK8IP3(6), MAPK9(1), MRAS(1), MYLK(7), MYLK2(1), P4HB(1), PAK1(3), PAK2(2), PAK3(3), PAK4(3), PAK6(3), PAK7(5), PIK3CB(7), PKLR(4), PLCG1(12), PLCG2(12), PTK2(2), RAF1(2), RALA(2), ROCK1(4), ROCK2(5), SHC1(1), SOS1(7), SOS2(5), SRC(2), TERF2IP(1), TLN1(5), TLN2(8), VASP(1), WAS(3), ZYX(2) 139954910 232 144 227 72 63 34 32 63 40 0 0.0646 1.000 1.000 429 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 78 ABL1(6), ABL2(3), AKT1(2), ARAF(1), AREG(3), BTC(1), CAMK2A(3), CAMK2D(1), CAMK2G(2), CBL(2), CBLB(3), CBLC(2), CDKN1A(2), CDKN1B(4), CRKL(2), EGF(10), ELK1(5), ERBB2(3), ERBB3(4), ERBB4(5), EREG(1), GSK3B(1), HBEGF(1), MAP2K1(1), MAP2K2(1), MAPK1(4), MAPK10(1), MAPK3(2), MAPK8(2), MAPK9(1), NRG1(5), NRG2(1), NRG4(1), PAK1(3), PAK2(2), PAK3(3), PAK4(3), PAK6(3), PAK7(5), PIK3CB(7), PIK3CD(3), PIK3CG(12), PIK3R2(4), PIK3R3(2), PIK3R5(4), PLCG1(12), PLCG2(12), PRKCA(6), PRKCG(4), PTK2(2), RAF1(2), RPS6KB1(2), RPS6KB2(3), SHC1(1), SHC2(1), SHC3(1), SHC4(2), SOS1(7), SOS2(5), SRC(2), STAT5A(1), STAT5B(2), TGFA(4) 111169950 206 137 203 59 58 30 27 50 39 2 0.0345 1.000 1.000 430 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 87 AKT1(2), CARD11(8), CBL(2), CBLB(3), CBLC(2), CD28(2), CD3D(1), CD3E(2), CD3G(1), CD4(2), CD40LG(2), CD8A(1), CDK4(1), CHUK(1), CSF2(2), CTLA4(1), FOS(2), FYN(2), GRAP2(2), ICOS(1), IFNG(2), IKBKB(2), IL10(1), IL5(1), ITK(1), LAT(2), LCK(1), LCP2(1), MALT1(4), MAP3K8(4), NFAT5(3), NFATC1(2), NFATC2(7), NFATC3(2), NFATC4(5), NFKB1(2), NFKB2(2), NFKBIA(3), NFKBIE(3), PAK1(3), PAK2(2), PAK3(3), PAK4(3), PAK6(3), PAK7(5), PDCD1(1), PDK1(2), PIK3CB(7), PIK3CD(3), PIK3CG(12), PIK3R2(4), PIK3R3(2), PIK3R5(4), PLCG1(12), PPP3CA(1), PPP3CB(1), PPP3CC(1), PRKCQ(4), PTPN6(1), PTPRC(9), RASGRP1(2), SOS1(7), SOS2(5), TEC(4), TNF(1), VAV1(9), VAV2(4), VAV3(3), ZAP70(8) 114181434 214 135 210 72 65 39 25 53 31 1 0.175 1.000 1.000 431 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 95 AKT1(2), CASP8(2), CCL3(1), CCL5(1), CD14(1), CD40(1), CD86(3), CHUK(1), CXCL9(1), FOS(2), IFNA10(2), IFNA5(1), IFNA6(1), IFNA7(1), IFNA8(1), IFNAR1(2), IFNAR2(2), IFNB1(2), IKBKB(2), IKBKE(5), IL12B(4), IL1B(3), IL6(2), IRAK1(3), IRAK4(2), IRF3(1), IRF5(2), IRF7(3), LBP(5), LY96(2), MAP2K1(1), MAP2K2(1), MAP2K3(6), MAP3K7(3), MAP3K8(4), MAPK1(4), MAPK10(1), MAPK12(2), MAPK13(2), MAPK3(2), MAPK8(2), MAPK9(1), NFKB1(2), NFKB2(2), NFKBIA(3), PIK3CB(7), PIK3CD(3), PIK3CG(12), PIK3R2(4), PIK3R3(2), PIK3R5(4), RAC1(1), RELA(1), RIPK1(4), SPP1(2), STAT1(4), TBK1(2), TICAM1(1), TLR1(6), TLR2(5), TLR3(6), TLR4(2), TLR5(4), TLR6(8), TLR7(10), TLR8(1), TLR9(5), TNF(1), TOLLIP(1), TRAF3(1) 101655710 194 132 191 75 61 37 22 45 27 2 0.303 1.000 1.000 432 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 89 ACVR1(3), ACVR1B(3), ACVR1C(3), ACVR2A(2), ACVRL1(6), AMHR2(2), BMP2(1), BMP4(3), BMP5(8), BMP6(3), BMPR1A(1), BMPR1B(1), BMPR2(1), CDKN2B(2), CHRD(2), COMP(1), CREBBP(13), CUL1(4), DCN(3), E2F4(1), E2F5(1), EP300(6), FST(1), GDF5(2), GDF6(2), GDF7(2), ID1(1), IFNG(2), INHBA(1), INHBB(1), INHBE(3), LEFTY2(4), LTBP1(8), MAPK1(4), MAPK3(2), NODAL(1), PITX2(7), PPP2CA(4), PPP2CB(1), PPP2R1B(2), PPP2R2A(4), PPP2R2C(3), RBL1(6), RBL2(3), RBX1(1), ROCK1(4), ROCK2(5), RPS6KB1(2), RPS6KB2(3), SMAD1(4), SMAD2(3), SMAD3(3), SMAD4(1), SMAD5(1), SMAD6(1), SMAD7(3), SMAD9(3), SMURF1(4), SMURF2(2), SP1(1), TFDP1(1), TGFB2(2), TGFB3(1), TGFBR1(4), TGFBR2(5), THBS1(6), THBS2(6), THBS3(5), THBS4(5), TNF(1), ZFYVE16(2), ZFYVE9(2) 117902449 215 128 215 55 59 34 33 54 34 1 0.00454 1.000 1.000 433 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 80 ABL1(6), ATM(12), BUB1(5), BUB1B(2), BUB3(3), CCNA1(3), CCNA2(1), CCNB1(2), CCNB2(1), CCNB3(6), CCND2(2), CCND3(1), CCNE1(2), CCNE2(2), CCNH(2), CDAN1(5), CDC14A(2), CDC14B(5), CDC20(1), CDC25A(1), CDC25B(1), CDC6(1), CDC7(2), CDH1(4), CDK2(1), CDK4(1), CDKN1A(2), CDKN2A(6), CHEK1(6), CHEK2(3), DTX4(4), E2F1(1), E2F2(1), E2F3(1), E2F4(1), E2F5(1), E2F6(1), EP300(6), ESPL1(8), GSK3B(1), HDAC2(7), HDAC3(1), HDAC4(4), HDAC5(1), HDAC6(4), MAD1L1(1), MCM2(1), MCM3(3), MCM4(5), MCM5(3), MCM6(6), MCM7(6), MDM2(5), MPEG1(3), MPL(5), PLK1(2), PRKDC(14), PTPRA(7), RBL1(6), SKP2(3), SMAD4(1), TBC1D8(4), TFDP1(1), WEE1(2) 127600580 211 125 210 67 44 41 24 62 37 3 0.218 1.000 1.000 434 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 68 ADH1A(3), ADH1B(4), ADH5(1), ADH6(3), ADH7(2), ADHFE1(2), AKR1C1(2), AKR1C2(1), AKR1C3(1), AKR1C4(2), ALDH1A3(5), ALDH3A1(6), ALDH3B2(3), CYP1A2(4), CYP1B1(2), CYP2B6(6), CYP2C18(4), CYP2C19(5), CYP2C8(4), CYP2C9(3), CYP2E1(2), CYP2F1(1), CYP2S1(2), CYP3A4(5), CYP3A43(1), CYP3A5(4), CYP3A7(2), EPHX1(4), GSTA1(3), GSTA2(1), GSTA3(1), GSTA4(3), GSTA5(4), GSTK1(2), GSTM4(1), GSTM5(1), GSTT1(1), GSTZ1(3), UGT1A1(5), UGT1A10(2), UGT1A3(3), UGT1A4(1), UGT1A5(3), UGT1A6(4), UGT1A7(3), UGT1A9(2), UGT2A1(9), UGT2B10(4), UGT2B11(5), UGT2B15(3), UGT2B17(2), UGT2B28(8), UGT2B4(9), UGT2B7(4) 66803619 171 120 169 56 56 22 22 53 18 0 0.173 1.000 1.000 435 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 82 ATF2(2), CHUK(1), CREB1(2), DAXX(5), ELK1(5), FOS(2), IKBKB(2), MAP2K1(1), MAP2K2(1), MAP2K3(6), MAP2K5(2), MAP3K1(9), MAP3K10(1), MAP3K12(6), MAP3K13(3), MAP3K3(2), MAP3K4(7), MAP3K5(4), MAP3K6(1), MAP3K7(3), MAP3K8(4), MAP3K9(6), MAP4K1(3), MAP4K2(1), MAP4K3(5), MAP4K4(4), MAP4K5(1), MAPK1(4), MAPK10(1), MAPK12(2), MAPK13(2), MAPK3(2), MAPK4(2), MAPK7(6), MAPK8(2), MAPK9(1), MAPKAPK2(2), MAPKAPK3(2), MAPKAPK5(2), MEF2A(4), MEF2B(1), MEF2D(1), MKNK1(2), NFKB1(2), NFKBIA(3), PAK1(3), PAK2(2), RAC1(1), RAF1(2), RELA(1), RIPK1(4), RPS6KA1(5), RPS6KA2(5), RPS6KA3(4), RPS6KA5(2), RPS6KB1(2), RPS6KB2(3), SHC1(1), SP1(1), STAT1(4), TGFB2(2), TGFB3(1), TGFBR1(4), TRADD(1), TRAF2(2) 110813558 180 120 177 60 46 31 29 35 37 2 0.197 1.000 1.000 436 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 ASH1L(5), ASH2L(2), CARM1(1), CTCFL(4), DOT1L(4), EHMT1(5), EHMT2(5), EZH1(2), EZH2(5), FBXO11(2), HCFC1(8), HSF4(2), JMJD4(2), JMJD6(4), KDM6A(6), MEN1(4), NSD1(5), OGT(9), PAXIP1(2), PPP1CA(1), PPP1CB(1), PPP1CC(1), PRDM2(5), PRDM7(2), PRDM9(18), PRMT1(1), PRMT5(4), PRMT6(1), PRMT7(1), PRMT8(5), RBBP5(3), SATB1(3), SETD1A(4), SETD2(15), SETD7(2), SETD8(1), SETDB1(8), SETDB2(1), SETMAR(3), SMYD3(2), STK38(1), SUV39H1(2), SUV39H2(1), SUV420H1(3), SUZ12(2), WHSC1L1(4) 141487274 172 116 171 45 46 29 24 43 30 0 0.0513 1.000 1.000 437 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CD2BP2(1), CDC40(2), CLK2(1), CLK3(3), CLK4(2), COL2A1(7), CPSF1(6), CPSF2(2), CPSF3(3), CSTF1(3), CSTF2(4), CSTF3(4), DDIT3(2), DDX20(1), DHX15(1), DHX16(4), DHX38(4), DHX8(8), DHX9(2), DICER1(7), FUS(4), METTL3(4), NCBP1(1), NCBP2(1), NONO(4), NUDT21(1), NXF1(1), PAPOLA(7), PHF5A(3), POLR2A(9), PRPF18(1), PRPF3(1), PRPF4(2), PRPF4B(4), PRPF8(12), PSKH1(1), PTBP1(3), RNGTT(4), SF3A1(2), SF3A2(1), SF3A3(2), SF3B1(8), SF3B2(2), SF3B4(1), SNRPA(1), SNRPB(2), SNRPB2(1), SNRPD2(1), SNRPD3(1), SNRPE(1), SNURF(2), SPOP(4), SRPK1(3), SRPK2(2), SRRM1(3), SUPT5H(2), TXNL4A(1), U2AF1(3), U2AF2(3), XRN2(3) 125614794 179 116 178 42 56 25 21 46 30 1 0.0282 1.000 1.000 438 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 AKT1(2), CALM1(1), CALM3(1), CHRM1(3), CHRNA1(4), FLT1(10), FLT4(8), KDR(14), NOS3(10), PDE2A(5), PDE3A(5), PDE3B(3), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), PRKG1(2), PRKG2(6), RYR2(58), SLC7A1(3), SYT1(2), TNNI1(1) 48217166 143 116 142 43 52 23 25 24 19 0 0.0274 1.000 1.000 439 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 91 ACTB(2), BCL2(2), CABIN1(11), CALM1(1), CALM3(1), CAMK4(3), CD3E(2), CD3G(1), CDKN1A(2), CEBPB(2), CNR1(1), CREBBP(13), CSF2(2), CSNK2A1(2), CSNK2B(3), CTLA4(1), EGR2(2), EGR3(2), EP300(6), FCER1A(4), FCGR3A(1), FOS(2), GATA3(3), GATA4(3), GSK3B(1), ICOS(1), IFNB1(2), IFNG(2), IL10(1), IL1B(3), IL3(2), IL6(2), ITK(1), KPNA5(4), MAPK8(2), MAPK9(1), MEF2A(4), MEF2B(1), MEF2D(1), MYF5(6), NFAT5(3), NFATC1(2), NFATC2(7), NFATC3(2), NFATC4(5), NFKB2(2), NFKBIE(3), NUP214(4), OPRD1(2), P2RX7(1), PAK1(3), PPP3CB(1), PPP3CC(1), PTPRC(9), RELA(1), RPL13A(2), SFN(3), SLA(2), SP1(1), SP3(5), TNF(1), TRAF2(2), VAV1(9), VAV2(4), VAV3(3), XPO5(1) 106320846 185 115 184 59 46 41 20 46 32 0 0.0744 1.000 1.000 440 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 70 AKT1(2), BTK(3), CSF2(2), FCER1A(4), FYN(2), GAB2(3), IL3(2), IL5(1), INPP5D(5), LAT(2), LCP2(1), LYN(2), MAP2K1(1), MAP2K2(1), MAP2K3(6), MAPK1(4), MAPK10(1), MAPK12(2), MAPK13(2), MAPK3(2), MAPK8(2), MAPK9(1), PDK1(2), PIK3CB(7), PIK3CD(3), PIK3CG(12), PIK3R2(4), PIK3R3(2), PIK3R5(4), PLA2G12B(1), PLA2G2D(1), PLA2G2F(1), PLA2G3(5), PLA2G4A(7), PLA2G5(1), PLA2G6(3), PLCG1(12), PLCG2(12), PRKCA(6), PRKCD(3), PRKCE(1), RAC1(1), RAC2(1), RAF1(2), SOS1(7), SOS2(5), TNF(1), VAV1(9), VAV2(4), VAV3(3) 80260270 171 113 168 55 53 30 23 39 24 2 0.103 1.000 1.000 441 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 69 ACACB(18), ACSL1(4), ACSL3(3), ACSL4(6), ACSL6(3), ADIPOR1(2), ADIPOR2(3), AGRP(1), AKT1(2), CAMKK1(2), CAMKK2(2), CD36(5), CHUK(1), CPT1A(2), CPT1C(2), CPT2(2), G6PC(8), G6PC2(1), IKBKB(2), IRS1(8), IRS2(1), IRS4(7), JAK1(3), JAK2(5), JAK3(5), LEPR(3), MAPK10(1), MAPK8(2), MAPK9(1), NFKB1(2), NFKB2(2), NFKBIA(3), NFKBIE(3), NPY(3), PCK1(6), PPARA(4), PPARGC1A(1), PRKAA1(3), PRKAA2(2), PRKAG1(1), PRKAG2(2), PRKAG3(1), PRKCQ(4), RELA(1), RXRA(4), RXRG(3), SLC2A1(4), SLC2A4(2), STAT3(3), STK11(1), TNF(1), TNFRSF1A(1), TNFRSF1B(3), TRADD(1), TRAF2(2), TYK2(10) 97149637 178 112 178 65 58 32 10 46 31 1 0.282 1.000 1.000 442 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 64 AGTR1(1), AGTR2(4), ATP8A1(5), AVPR1A(6), AVPR1B(2), AVPR2(4), BDKRB1(1), BRS3(1), C3AR1(3), CCKAR(1), CCKBR(2), CCR1(1), CCR10(1), CCR2(2), CCR3(2), CCR4(2), CCR5(1), CCR6(3), CCR7(1), CCR8(3), CX3CR1(3), CXCR4(2), CXCR6(1), EDNRA(1), EDNRB(1), FPR1(1), FSHR(3), GALR1(2), GALT(1), GHSR(2), GNB2L1(2), GNRHR(3), GRPR(4), LHCGR(2), MC1R(3), MC2R(2), MC3R(6), MC4R(6), MC5R(5), NMBR(6), NPY1R(3), NPY2R(2), NPY5R(3), NTSR1(4), OPRD1(2), OPRL1(3), OPRM1(4), SSTR2(3), SSTR3(6), TACR2(2), TACR3(7), TRHR(2), TSHR(5) 60420138 148 112 148 67 66 19 23 33 7 0 0.516 1.000 1.000 443 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 52 ADORA3(2), ALG6(3), CCKBR(2), CCR2(2), CCR3(2), CCR5(1), CELSR1(13), CELSR2(14), CELSR3(17), CHRM2(3), CHRM3(4), EDNRA(1), EMR2(6), EMR3(2), F2R(2), FSHR(3), GHRHR(3), GNRHR(3), GPR116(12), GPR132(7), GPR133(7), GPR143(6), GPR17(2), GPR18(2), GPR61(4), GPR84(2), GRM1(6), GRPR(4), HRH4(2), LGR6(1), LPHN2(8), LPHN3(7), LTB4R2(1), NTSR1(4), OR2M4(2), P2RY13(1), PTGFR(7), SMO(3), SSTR2(3), TAAR5(1), TSHR(5) 79240348 180 110 178 77 69 31 22 44 14 0 0.473 1.000 1.000 444 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 65 AKT1(2), CASP9(1), KDR(14), MAP2K1(1), MAP2K2(1), MAPK1(4), MAPK12(2), MAPK13(2), MAPK3(2), MAPKAPK2(2), MAPKAPK3(2), NFAT5(3), NFATC1(2), NFATC2(7), NFATC3(2), NFATC4(5), NOS3(10), PIK3CB(7), PIK3CD(3), PIK3CG(12), PIK3R2(4), PIK3R3(2), PIK3R5(4), PLA2G12B(1), PLA2G2D(1), PLA2G2F(1), PLA2G3(5), PLA2G4A(7), PLA2G5(1), PLA2G6(3), PLCG1(12), PLCG2(12), PPP3CA(1), PPP3CB(1), PPP3CC(1), PRKCA(6), PRKCG(4), PTGS2(3), PTK2(2), PXN(1), RAC1(1), RAC2(1), RAF1(2), SH2D2A(1), SHC2(1), SRC(2), VEGFA(3) 80214810 167 108 165 52 54 27 21 36 27 2 0.0310 1.000 1.000 445 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ADCY4(6), ADCY6(2), ADCY8(3), CACNA1A(5), CACNA1B(15), GNAS(4), GNAT3(5), GNB1(1), GNB3(1), GRM4(6), ITPR3(18), KCNB1(5), PDE1A(3), PLCB2(7), PRKACG(1), PRKX(1), SCNN1A(1), SCNN1B(6), SCNN1G(6), TAS1R1(2), TAS1R2(5), TAS1R3(1), TAS2R1(5), TAS2R10(3), TAS2R13(1), TAS2R16(5), TAS2R3(1), TAS2R38(1), TAS2R39(1), TAS2R4(2), TAS2R40(2), TAS2R41(5), TAS2R42(1), TAS2R46(1), TAS2R5(2), TAS2R60(1), TAS2R7(1), TAS2R9(4), TRPM5(3) 67850887 143 108 142 53 61 21 15 28 18 0 0.308 1.000 1.000 446 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 44 AKT1(2), BCL2(2), BCR(3), BLNK(2), BTK(3), CD19(2), CD22(9), CD81(2), CR2(8), CSK(2), DAG1(3), FLOT1(1), FLOT2(3), GSK3B(1), INPP5D(5), ITPR1(9), ITPR2(15), ITPR3(18), LYN(2), MAP4K1(3), MAPK1(4), MAPK3(2), NFATC1(2), NFATC2(7), NR0B2(1), PDK1(2), PIK3CD(3), PLCG2(12), PPP1R13B(1), PPP3CA(1), PPP3CB(1), PPP3CC(1), PTPRC(9), RAF1(2), SHC1(1), SOS1(7), SOS2(5), VAV1(9) 83451435 165 108 165 55 57 27 18 39 22 2 0.0967 1.000 1.000 447 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 45 INPP1(1), INPP4A(1), INPP4B(5), INPP5A(1), INPP5B(4), INPP5E(1), INPPL1(8), IPMK(2), ISYNA1(2), ITPK1(3), MINPP1(1), MIOX(1), OCRL(7), PI4KA(8), PI4KB(4), PIK3C3(2), PIK3CB(7), PIK3CD(3), PIK3CG(12), PIP4K2A(1), PIP4K2B(1), PIP4K2C(5), PIP5K1B(3), PIP5K1C(2), PLCB1(4), PLCB2(7), PLCB3(4), PLCB4(4), PLCD1(4), PLCD3(2), PLCE1(10), PLCG1(12), PLCG2(12), PLCZ1(5), PTPMT1(1), SYNJ1(6), SYNJ2(11) 84788221 167 107 165 54 47 29 17 48 26 0 0.214 1.000 1.000 448 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 77 AIFM1(6), AKT1(2), APAF1(3), ATM(12), BAX(1), BCL2(2), BIRC2(3), BIRC3(1), CAPN1(2), CASP10(1), CASP8(2), CASP9(1), CFLAR(1), CHUK(1), CSF2RB(6), CYCS(2), DFFA(2), FAS(1), FASLG(1), IKBKB(2), IL1A(1), IL1B(3), IL1R1(4), IL1RAP(2), IL3(2), IL3RA(4), IRAK1(3), IRAK2(3), IRAK3(9), IRAK4(2), NFKB1(2), NFKB2(2), NFKBIA(3), NTRK1(3), PIK3CB(7), PIK3CD(3), PIK3CG(12), PIK3R2(4), PIK3R3(2), PIK3R5(4), PPP3CA(1), PPP3CB(1), PPP3CC(1), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), RELA(1), RIPK1(4), TNF(1), TNFRSF10C(1), TNFRSF10D(1), TNFRSF1A(1), TNFSF10(2), TRADD(1), TRAF2(2) 93891892 149 107 148 52 39 25 17 40 28 0 0.438 1.000 1.000 449 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 62 APAF1(3), ATM(12), ATR(10), BAI1(4), BAX(1), CASP8(2), CASP9(1), CCNB1(2), CCNB2(1), CCNB3(6), CCND1(4), CCND2(2), CCND3(1), CCNE1(2), CCNE2(2), CCNG1(2), CCNG2(2), CDK2(1), CDK4(1), CDKN1A(2), CDKN2A(6), CHEK1(6), CHEK2(3), CYCS(2), DDB2(3), EI24(4), FAS(1), GADD45B(1), GTSE1(5), IGF1(3), MDM2(5), MDM4(2), PPM1D(4), RCHY1(1), RFWD2(4), RPRM(1), RRM2(1), RRM2B(1), SERPINB5(2), SERPINE1(4), SESN1(2), SESN2(1), SESN3(2), SFN(3), SIAH1(3), STEAP3(2), THBS1(6), TP53I3(1), TSC2(6), ZMAT3(3) 75582767 149 105 147 40 27 22 27 42 31 0 0.0630 1.000 1.000 450 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 58 AKT1(2), BLNK(2), BTK(3), CARD11(8), CD19(2), CD22(9), CD72(3), CD79A(1), CD81(2), CHUK(1), CR2(8), FOS(2), GSK3B(1), IFITM1(2), IKBKB(2), INPP5D(5), LILRB3(3), LYN(2), MALT1(4), NFAT5(3), NFATC1(2), NFATC2(7), NFATC3(2), NFATC4(5), NFKB1(2), NFKB2(2), NFKBIA(3), NFKBIE(3), PIK3CB(7), PIK3CD(3), PIK3CG(12), PIK3R2(4), PIK3R3(2), PIK3R5(4), PLCG2(12), PPP3CA(1), PPP3CB(1), PPP3CC(1), PTPN6(1), RAC1(1), RAC2(1), RASGRP3(2), VAV1(9), VAV2(4), VAV3(3) 82882412 159 103 159 65 60 33 7 34 25 0 0.431 1.000 1.000 451 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 55 BMP2(1), BMP4(3), BMP5(8), BMP6(3), BTRC(2), CSNK1A1(2), CSNK1A1L(2), CSNK1D(2), CSNK1E(1), CSNK1G1(2), CSNK1G2(2), CSNK1G3(1), DHH(1), FBXW11(1), GLI1(6), GLI2(6), GLI3(6), GSK3B(1), HHIP(3), IHH(3), LRP2(37), PRKACG(1), PRKX(1), PTCH1(3), PTCH2(2), RAB23(2), SHH(3), SMO(3), STK36(2), SUFU(4), WNT1(1), WNT10A(2), WNT11(5), WNT16(2), WNT2B(2), WNT3(1), WNT3A(1), WNT5B(2), WNT7A(2), WNT8A(2), WNT8B(1), WNT9A(2), WNT9B(2), ZIC2(1) 71563786 140 99 139 42 56 22 18 23 21 0 0.0583 1.000 1.000 452 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACAA1(1), ACADL(1), ACADM(2), ACOX1(2), ACOX2(3), ACOX3(3), ACSL1(4), ACSL3(3), ACSL4(6), ACSL6(3), ANGPTL4(1), APOA1(1), APOA5(1), AQP7(4), CD36(5), CPT1A(2), CPT1C(2), CPT2(2), CYP27A1(2), CYP4A11(5), CYP4A22(2), CYP7A1(3), CYP8B1(3), DBI(1), EHHADH(2), FABP1(1), FABP4(1), FABP6(2), FABP7(1), FADS2(2), GK(1), GK2(5), HMGCS2(3), ILK(1), LPL(2), ME1(2), MMP1(3), NR1H3(5), OLR1(2), PCK1(6), PLTP(1), PPARA(4), PPARG(3), RXRA(4), RXRG(3), SCD(1), SCP2(1), SLC27A1(3), SLC27A2(8), SLC27A4(1), SLC27A5(4), SLC27A6(4), SORBS1(3), UBC(7) 77675011 148 98 145 52 45 28 17 40 18 0 0.210 1.000 1.000 453 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 41 APH1A(2), CREBBP(13), CTBP1(5), CTBP2(4), DLL1(1), DLL3(1), DTX1(4), DTX2(1), DTX3L(2), DTX4(4), DVL1(1), DVL2(3), DVL3(3), EP300(6), HDAC2(7), HES1(1), JAG1(7), JAG2(5), LFNG(3), MAML1(6), MAML2(2), MAML3(4), MFNG(1), NCOR2(9), NCSTN(5), NOTCH2(16), NOTCH3(7), NOTCH4(10), NUMB(1), NUMBL(2), PSEN1(1), RBPJL(5), SNW1(2) 76436306 144 98 143 52 40 22 18 27 36 1 0.513 1.000 1.000 454 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 AICDA(4), CAD(8), CANT1(4), CDA(3), CTPS2(2), DCK(2), DCTD(1), DHODH(2), DPYD(6), DPYS(5), DTYMK(1), ENTPD1(4), ENTPD5(1), ENTPD6(2), ENTPD8(1), NME7(2), NT5C(3), NT5C1A(1), NT5C1B(7), NT5C2(1), NT5E(3), NT5M(1), NUDT2(1), PNPT1(1), POLA1(3), POLA2(2), POLD1(3), POLD2(2), POLD3(2), POLD4(1), POLE(8), POLE2(1), POLR1A(7), POLR1B(3), POLR2A(9), POLR2B(4), POLR2C(2), POLR2G(1), POLR3A(7), POLR3B(3), POLR3G(1), POLR3GL(1), POLR3K(1), PRIM1(2), PRIM2(1), RRM1(3), RRM2(1), RRM2B(1), TK2(3), TXNRD1(1), TXNRD2(5), UCK1(4), UMPS(1), UPP1(3), UPP2(3), UPRT(2) 96254638 157 97 156 48 34 28 22 48 25 0 0.171 1.000 1.000 455 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 61 AKT1(2), CDK2(1), CDKN1B(4), CDKN2A(6), CREB1(2), ERBB4(5), GSK3B(1), IFI27(1), IGF1(3), INPPL1(8), IRS1(8), IRS2(1), IRS4(7), MET(13), PAK1(3), PAK2(2), PAK3(3), PAK4(3), PAK6(3), PAK7(5), PARD3(3), PARD6A(1), PDK1(2), PIK3CD(3), PPP1R13B(1), PREX1(10), PTK2(2), PTPN1(1), RPS6KA1(5), RPS6KA2(5), RPS6KA3(4), RPS6KB1(2), SFN(3), SHC1(1), SLC2A4(2), SOS1(7), SOS2(5), TSC1(2), TSC2(6), YWHAB(2), YWHAE(3), YWHAG(1), YWHAH(2), YWHAQ(1), YWHAZ(1) 88165016 156 97 154 36 33 19 28 43 33 0 0.00911 1.000 1.000 456 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 61 ATM(12), CCNA1(3), CCNB1(2), CCND1(4), CCND2(2), CCND3(1), CCNE1(2), CCNE2(2), CCNG2(2), CCNH(2), CDC25A(1), CDK2(1), CDK4(1), CDK7(1), CDKN1A(2), CDKN1B(4), CDKN2A(6), CDKN2B(2), CREB3L1(2), CREB3L3(3), CREB3L4(1), E2F1(1), E2F2(1), E2F3(1), E2F4(1), E2F5(1), E2F6(1), GBA2(1), MCM2(1), MCM3(3), MCM4(5), MCM5(3), MCM6(6), MCM7(6), MDM2(5), MYT1(7), NACA(6), POLA2(2), POLE(8), POLE2(1), PRIM1(2), RBL1(6), RPA1(3), RPA2(1), TFDP1(1), TNXB(14), WEE1(2) 88206123 145 95 144 42 26 17 21 42 39 0 0.195 1.000 1.000 457 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 53 AKR1C4(2), AKR1D1(1), ARSD(3), ARSE(6), CARM1(1), CYP11B1(2), CYP11B2(3), CYP19A1(2), HSD11B1(2), HSD17B3(1), HSD17B7(2), HSD17B8(1), HSD3B1(2), HSD3B2(1), LCMT1(3), LCMT2(2), METTL2B(3), METTL6(2), PRMT2(2), PRMT5(4), PRMT6(1), PRMT7(1), PRMT8(5), SRD5A1(2), STS(2), SULT2A1(2), SULT2B1(3), UGT1A1(5), UGT1A10(2), UGT1A3(3), UGT1A4(1), UGT1A5(3), UGT1A6(4), UGT1A7(3), UGT1A9(2), UGT2A1(9), UGT2B10(4), UGT2B11(5), UGT2B15(3), UGT2B17(2), UGT2B28(8), UGT2B4(9), UGT2B7(4), WBSCR22(2) 58410403 130 94 127 46 38 19 20 39 14 0 0.280 1.000 1.000 458 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 63 ADAM10(4), ATP6AP1(3), ATP6V0A2(1), ATP6V0A4(3), ATP6V0C(1), ATP6V0D1(2), ATP6V0D2(3), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(1), ATP6V1E2(2), ATP6V1G1(1), ATP6V1G3(2), ATP6V1H(1), CCL5(1), CHUK(1), CSK(2), CXCL1(1), F11R(2), GIT1(2), HBEGF(1), IKBKB(2), JAM2(4), JAM3(2), LYN(2), MAPK10(1), MAPK12(2), MAPK13(2), MAPK8(2), MAPK9(1), MET(13), NFKB1(2), NFKB2(2), NFKBIA(3), NOD1(3), PAK1(3), PLCG1(12), PLCG2(12), PTPRZ1(15), RAC1(1), RELA(1), SRC(2), TCIRG1(2), TJP1(8) 78837630 139 92 136 41 34 23 21 30 30 1 0.0829 1.000 1.000 459 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 41 ACTR2(2), ACTR3(1), AKT1(2), ANGPTL2(3), ARHGAP1(1), ARHGAP4(4), ARHGEF11(4), BTK(3), CFL1(1), CFL2(2), GDI1(4), GDI2(1), INPPL1(8), ITPR1(9), ITPR2(15), ITPR3(18), LIMK1(4), MYLK(7), MYLK2(1), PAK1(3), PAK2(2), PAK3(3), PAK4(3), PAK6(3), PAK7(5), PDK1(2), PIK3CD(3), PIK3CG(12), PITX2(7), PPP1R13B(1), ROCK1(4), ROCK2(5), RPS4X(3), SAG(2), WASF1(1), WASL(2) 78081680 151 92 149 45 47 31 22 31 19 1 0.0412 1.000 1.000 460 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 31 AKT1(2), BCR(3), BTK(3), CD19(2), CDKN2A(6), FLOT1(1), FLOT2(3), ITPR1(9), ITPR2(15), ITPR3(18), LYN(2), NR0B2(1), PDK1(2), PHF11(1), PITX2(7), PLCG2(12), PPP1R13B(1), PREX1(10), PTPRC(9), RPS6KA1(5), RPS6KA2(5), RPS6KA3(4), RPS6KB1(2), SAG(2), TEC(4), VAV1(9) 62133992 138 91 137 43 45 23 18 32 19 1 0.0676 1.000 1.000 461 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 AANAT(2), ACAT2(1), ACMSD(2), ALDH1A1(2), ALDH1A2(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), AOC2(1), AOX1(9), ASMT(2), CAT(3), CYP19A1(2), CYP1A2(4), CYP2A13(2), CYP2A7(1), CYP2B6(6), CYP2C18(4), CYP2C19(5), CYP2C8(4), CYP2C9(3), CYP2D6(2), CYP2E1(2), CYP2F1(1), CYP3A4(5), CYP3A5(4), CYP3A7(2), CYP4B1(5), CYP51A1(2), DDC(5), ECHS1(3), EHHADH(2), GCDH(1), HADHA(3), KMO(3), KYNU(2), MAOA(3), MAOB(2), SDS(1), TDO2(2), TPH1(5), WARS(1), WARS2(2) 65351752 129 91 126 44 56 16 10 29 18 0 0.212 1.000 1.000 462 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(1), ACSS2(4), ACYP1(1), ADH1A(3), ADH1B(4), ADH5(1), ADH6(3), ADH7(2), ADHFE1(2), AKR1A1(3), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3B2(3), ALDH7A1(2), ALDOA(1), ALDOB(2), BPGM(2), DLD(3), ENO1(2), ENO2(2), ENO3(2), FBP1(3), FBP2(2), G6PC(8), G6PC2(1), GALM(1), GAPDH(1), GAPDHS(2), GCK(2), GPI(2), HK1(4), HK2(5), HK3(5), LDHA(1), LDHAL6A(1), LDHAL6B(2), LDHB(2), LDHC(1), PDHA1(6), PDHA2(7), PDHB(1), PFKL(5), PFKP(1), PGAM2(1), PGAM4(2), PGK1(3), PGK2(1), PGM1(1), PGM3(1), PKLR(4), TPI1(1) 69075635 136 90 134 37 52 26 10 33 15 0 0.00739 1.000 1.000 463 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(2), AGPAT1(2), AGPAT2(2), AGPAT3(1), AGPS(3), CDS2(2), CHAT(6), CHKB(1), CLC(1), DGKA(4), DGKB(3), DGKD(8), DGKE(3), DGKG(4), DGKH(4), DGKQ(3), DGKZ(2), ETNK1(1), GNPAT(2), GPD2(2), LCAT(1), LGALS13(4), LYPLA1(1), PAFAH1B1(4), PAFAH2(2), PCYT1A(2), PCYT1B(2), PISD(2), PLA2G3(5), PLA2G4A(7), PLA2G5(1), PLA2G6(3), PLCB2(7), PLCG1(12), PLCG2(12), PPAP2A(2), PPAP2C(1) 59366754 124 88 121 31 40 26 12 29 17 0 0.00859 1.000 1.000 464 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 40 ALAD(2), ALAS1(2), ALAS2(1), BLVRA(2), COX10(5), COX15(1), CP(7), EARS2(1), EPRS(5), FECH(2), FTH1(3), FTMT(4), GUSB(3), HCCS(5), HMBS(1), HMOX1(1), MMAB(3), PPOX(2), UGT1A1(5), UGT1A10(2), UGT1A3(3), UGT1A4(1), UGT1A5(3), UGT1A6(4), UGT1A7(3), UGT1A9(2), UGT2A1(9), UGT2B10(4), UGT2B11(5), UGT2B15(3), UGT2B17(2), UGT2B28(8), UGT2B4(9), UGT2B7(4), UROD(1), UROS(1) 48843888 119 87 117 35 35 15 20 42 7 0 0.161 1.000 1.000 465 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 51 ACTG1(1), APAF1(3), ARHGDIB(1), BAG4(1), BCL2(2), BIRC2(3), BIRC3(1), CASP2(1), CASP8(2), CASP9(1), CFLAR(1), CHUK(1), CRADD(2), CYCS(2), DAXX(5), DFFA(2), GSN(2), LMNA(2), LMNB2(3), MAP3K1(9), MAP3K5(4), MAPK8(2), MDM2(5), NFKB1(2), NFKBIA(3), NUMA1(11), PAK2(2), PRKCD(3), PRKDC(14), PSEN1(1), PTK2(2), RASA1(4), RELA(1), RIPK1(4), SPTAN1(8), TNF(1), TNFRSF1A(1), TNFRSF1B(3), TRADD(1), TRAF1(1), TRAF2(2) 80259293 120 86 117 37 31 21 19 31 17 1 0.176 1.000 1.000 466 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG1(1), ACTG2(2), ACTR2(2), ACTR3(1), AKT1(2), ANGPTL2(3), CFL1(1), CFL2(2), FLNA(18), FLNC(16), FSCN1(2), FSCN2(2), FSCN3(3), GDI1(4), GDI2(1), LIMK1(4), MYH2(25), MYLK(7), MYLK2(1), PAK1(3), PAK2(2), PAK3(3), PAK4(3), PAK6(3), PAK7(5), ROCK1(4), ROCK2(5), RPS4X(3), VASP(1), WASF1(1), WASL(2) 57053538 132 86 127 40 57 16 15 27 16 1 0.0317 1.000 1.000 467 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(2), ALPP(7), ALPPL2(6), ASCC3(7), ATP13A2(3), DDX18(1), DDX19A(2), DDX23(3), DDX4(5), DDX41(5), DDX47(2), DDX51(3), DDX52(2), DDX54(2), DDX55(1), DDX56(4), DHFR(1), DHX58(2), ENTPD7(2), EP400(9), ERCC2(3), ERCC3(2), FPGS(2), GGH(1), IFIH1(3), MOV10L1(7), QDPR(2), RAD54B(5), RAD54L(6), RUVBL2(4), SETX(5), SKIV2L2(3), SMARCA2(5), SMARCA5(3), SPR(1) 74571237 121 84 119 42 40 21 14 26 20 0 0.390 1.000 1.000 468 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 57 BAK1(2), BAX(1), BFAR(1), BTK(3), CAD(8), CASP10(1), CASP8(2), CD7(3), CSNK1A1(2), DAXX(5), DEDD(1), DEDD2(2), DFFA(2), DIABLO(1), EPHB2(5), FAF1(4), IL1A(1), MAP3K1(9), MAP3K5(4), MAPK1(4), MAPK10(1), MAPK8(2), MAPK8IP1(3), MAPK8IP2(4), MAPK8IP3(6), MAPK9(1), MET(13), NFAT5(3), NFKB1(2), NFKB2(2), NFKBIA(3), NFKBIE(3), NR0B2(1), PTPN13(4), RALBP1(3), RIPK1(4), ROCK1(4), SMPD1(1), TNFRSF6B(1), TPX2(7), TRAF2(2) 82587963 131 84 129 34 37 25 24 22 23 0 0.0171 1.000 1.000 469 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ADH1A(3), ADH1B(4), ADH6(3), ADH7(2), ADHFE1(2), AKR1A1(3), ALDH1A1(2), ALDH1A2(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3B2(3), ALDOA(1), ALDOB(2), BPGM(2), DLD(3), ENO1(2), ENO2(2), ENO3(2), FBP1(3), FBP2(2), G6PC(8), GAPDH(1), GCK(2), GPI(2), HK1(4), HK2(5), HK3(5), LDHA(1), LDHB(2), LDHC(1), PDHA1(6), PDHA2(7), PDHB(1), PFKP(1), PGK1(3), PGM1(1), PGM3(1), PKLR(4), TPI1(1) 57967625 116 80 114 35 45 26 8 26 11 0 0.0380 1.000 1.000 470 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ADH1A(3), ADH1B(4), ADH6(3), ADH7(2), ADHFE1(2), AKR1A1(3), ALDH1A1(2), ALDH1A2(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3B2(3), ALDOA(1), ALDOB(2), BPGM(2), DLD(3), ENO1(2), ENO2(2), ENO3(2), FBP1(3), FBP2(2), G6PC(8), GAPDH(1), GCK(2), GPI(2), HK1(4), HK2(5), HK3(5), LDHA(1), LDHB(2), LDHC(1), PDHA1(6), PDHA2(7), PDHB(1), PFKP(1), PGK1(3), PGM1(1), PGM3(1), PKLR(4), TPI1(1) 57967625 116 80 114 35 45 26 8 26 11 0 0.0380 1.000 1.000 471 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AADAT(1), AANAT(2), ACAT2(1), ACMSD(2), AFMID(1), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH7A1(2), AOC2(1), AOX1(9), ASMT(2), CARM1(1), CAT(3), CYP1A2(4), CYP1B1(2), DDC(5), ECHS1(3), EHHADH(2), GCDH(1), HADHA(3), HSD17B4(3), KMO(3), KYNU(2), LCMT1(3), LCMT2(2), LNX1(4), MAOA(3), MAOB(2), METTL2B(3), METTL6(2), NFX1(3), OGDH(1), OGDHL(7), PRMT2(2), PRMT5(4), PRMT6(1), PRMT7(1), PRMT8(5), TDO2(2), TPH1(5), TPH2(2), WARS(1), WARS2(2), WBSCR22(2) 71939912 126 80 123 45 46 15 13 32 20 0 0.345 1.000 1.000 472 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 22 INPP1(1), INPP4A(1), INPP4B(5), INPP5A(1), INPPL1(8), MIOX(1), OCRL(7), PIK3C2A(5), PIK3C2B(3), PIK3C2G(10), PIK3CB(7), PIK3CG(12), PLCB1(4), PLCB2(7), PLCB3(4), PLCB4(4), PLCD1(4), PLCG1(12), PLCG2(12) 50675808 108 79 106 42 32 18 12 30 16 0 0.662 1.000 1.000 473 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 41 BCL2(2), CHUK(1), DAXX(5), EGF(10), ETS1(5), FOS(2), HOXA7(2), IKBKB(2), MAP2K1(1), MAP2K3(6), MAP3K1(9), MAP3K5(4), MAPK1(4), MAPK13(2), MAPK3(2), MAPK8(2), NFKB1(2), NFKBIA(3), PPP2CA(4), PRKCA(6), PRKCD(3), PRKCE(1), PRKCG(4), PRKCH(3), PRKCQ(4), RAF1(2), RELA(1), RIPK1(4), SP1(1), TNF(1), TNFRSF1A(1), TNFRSF1B(3), TRAF2(2) 55196412 104 78 100 34 32 21 14 17 17 3 0.121 1.000 1.000 474 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 65 APAF1(3), BAK1(2), BAX(1), BCL2(2), BCL2L11(1), BIRC2(3), BIRC3(1), CASP1(6), CASP10(1), CASP2(1), CASP4(1), CASP8(2), CASP9(1), CHUK(1), CYCS(2), DFFA(2), FAS(1), FASLG(1), GZMB(3), HELLS(3), IKBKB(2), IRF1(5), IRF2(2), IRF3(1), IRF4(4), IRF5(2), IRF6(4), IRF7(3), MAP3K1(9), MAPK10(1), MDM2(5), NFKB1(2), NFKBIA(3), NFKBIE(3), PLEKHG5(4), PRF1(3), RELA(1), RIPK1(4), TNF(1), TNFRSF1A(1), TNFRSF1B(3), TNFRSF21(2), TNFRSF25(2), TNFSF10(2), TRADD(1), TRAF1(1), TRAF2(2), TRAF3(1) 67092782 112 77 110 39 38 20 9 26 19 0 0.294 1.000 1.000 475 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 AKR1C3(1), ALOX12(1), ALOX12B(2), ALOX15(2), ALOX15B(1), ALOX5(2), CBR1(2), CBR3(1), CYP2B6(6), CYP2C18(4), CYP2C19(5), CYP2C8(4), CYP2C9(3), CYP2E1(2), CYP2U1(2), CYP4A11(5), CYP4A22(2), CYP4F2(3), CYP4F3(6), DHRS4(1), EPHX2(2), GGT1(3), GPX2(2), GPX5(1), GPX6(1), LTA4H(4), PLA2G12B(1), PLA2G2D(1), PLA2G2F(1), PLA2G3(5), PLA2G4A(7), PLA2G5(1), PLA2G6(3), PTGES(1), PTGES2(1), PTGIS(2), PTGS1(3), PTGS2(3), TBXAS1(2) 46240610 99 77 98 34 35 15 9 23 17 0 0.237 1.000 1.000 476 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 30 ACTR2(2), ACTR3(1), AKT1(2), ANGPTL2(3), DAG1(3), DGKA(4), GCA(1), ITGA9(2), ITPR1(9), ITPR2(15), ITPR3(18), MAP2K1(1), MAPK1(4), MAPK3(2), NR1I3(1), PAK1(3), PDE3A(5), PDE3B(3), PI3(2), PIK3C2G(10), PIK3CD(3), PSME1(3), RIPK3(1), RPS4X(3), SGCB(1), VASP(1) 53497057 103 77 101 37 27 16 20 19 19 2 0.313 1.000 1.000 477 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 55 ADH1A(3), ADH1B(4), ADH5(1), ADH6(3), ADH7(2), ADHFE1(2), ALDH1A3(5), ALDH3A1(6), ALDH3B2(3), AOC2(1), AOX1(9), CARM1(1), DBH(4), DCT(1), DDC(5), ECH1(1), ESCO1(2), ESCO2(2), FAH(2), GOT1(2), GOT2(1), GSTZ1(3), HGD(5), HPD(1), LCMT1(3), LCMT2(2), MAOA(3), MAOB(2), METTL2B(3), METTL6(2), PNPLA3(1), PRMT2(2), PRMT5(4), PRMT6(1), PRMT7(1), PRMT8(5), SH3GLB1(3), TAT(3), TH(3), TPO(10), TYR(5), WBSCR22(2) 69336429 124 76 121 37 46 16 13 35 14 0 0.0605 1.000 1.000 478 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 47 ACOX1(2), APOA1(1), CD36(5), CITED2(1), CREBBP(13), DUSP1(1), EHHADH(2), EP300(6), FABP1(1), HSD17B4(3), INS(1), LPL(2), MAPK1(4), MAPK3(2), ME1(2), NCOA1(3), NCOR1(9), NCOR2(9), NFKBIA(3), NR0B2(1), NR1H3(5), NR2F1(1), NRIP1(4), PDGFA(1), PPARA(4), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), PRKCA(6), PTGS2(3), RELA(1), RXRA(4), SP1(1), STAT5A(1), STAT5B(2), TNF(1) 68617586 110 74 108 40 30 17 11 26 23 3 0.447 1.000 1.000 479 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 64 ACHE(2), AGPAT1(2), AGPAT2(2), AGPAT3(1), AGPAT6(2), CDS2(2), CHAT(6), CHKB(1), CRLS1(1), DGKA(4), DGKB(3), DGKD(8), DGKE(3), DGKG(4), DGKH(4), DGKI(2), DGKQ(3), DGKZ(2), ESCO1(2), ESCO2(2), ETNK1(1), ETNK2(2), GNPAT(2), GPAM(1), GPD2(2), LCAT(1), LYPLA1(1), PCYT1A(2), PCYT1B(2), PHOSPHO1(1), PISD(2), PLA2G12B(1), PLA2G2D(1), PLA2G2F(1), PLA2G3(5), PLA2G4A(7), PLA2G5(1), PLA2G6(3), PLD1(8), PNPLA3(1), PPAP2A(2), PPAP2C(1), PTDSS1(5), SH3GLB1(3) 77903633 112 73 111 25 38 25 10 26 13 0 0.00272 1.000 1.000 480 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 50 ABL1(6), ACTB(2), ACTG1(1), ARHGEF2(5), CD14(1), CDH1(4), CLDN1(1), CTNNB1(3), CTTN(3), EZR(4), FYN(2), HCLS1(4), ITGB1(3), KRT18(3), LY96(2), NCL(3), OCLN(3), PRKCA(6), ROCK1(4), ROCK2(5), TLR4(2), TLR5(4), TUBA1A(3), TUBA1B(1), TUBA3C(11), TUBA3D(2), TUBA4A(2), TUBA8(2), TUBB(1), TUBB6(3), TUBB8(3), WAS(3), WASL(2), YWHAQ(1), YWHAZ(1) 61511227 106 73 106 37 42 17 16 18 12 1 0.189 1.000 1.000 481 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 50 ABL1(6), ACTB(2), ACTG1(1), ARHGEF2(5), CD14(1), CDH1(4), CLDN1(1), CTNNB1(3), CTTN(3), EZR(4), FYN(2), HCLS1(4), ITGB1(3), KRT18(3), LY96(2), NCL(3), OCLN(3), PRKCA(6), ROCK1(4), ROCK2(5), TLR4(2), TLR5(4), TUBA1A(3), TUBA1B(1), TUBA3C(11), TUBA3D(2), TUBA4A(2), TUBA8(2), TUBB(1), TUBB6(3), TUBB8(3), WAS(3), WASL(2), YWHAQ(1), YWHAZ(1) 61511227 106 73 106 37 42 17 16 18 12 1 0.189 1.000 1.000 482 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 AKT1(2), APC(3), ASAH1(2), CAV3(1), DAG1(3), DLG4(5), EPHB2(5), GNAI1(4), ITPR1(9), ITPR2(15), ITPR3(18), KCNJ3(2), KCNJ5(5), KCNJ9(1), MAPK1(4), PITX2(7), PTX3(2), RAC1(1), RYR1(16) 54509157 105 73 105 31 33 18 21 18 14 1 0.0440 1.000 1.000 483 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 57 APC(3), AXIN1(4), CCND1(4), CCND2(2), CCND3(1), CSNK1E(1), CTNNB1(3), DVL1(1), DVL2(3), DVL3(3), FZD1(3), FZD10(5), FZD5(1), FZD6(2), FZD7(2), FZD8(2), FZD9(4), GSK3B(1), LDLR(3), MAPK10(1), MAPK9(1), PAFAH1B1(4), PPP2R5C(1), PPP2R5E(3), PRKCA(6), PRKCD(3), PRKCE(1), PRKCG(4), PRKCH(3), PRKCI(2), PRKCQ(4), PRKD1(1), RAC1(1), SFRP4(1), WNT1(1), WNT10A(2), WNT11(5), WNT16(2), WNT2B(2), WNT3(1), WNT5B(2), WNT7A(2) 70517248 101 72 100 34 32 11 16 18 22 2 0.260 1.000 1.000 484 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 CAD(8), CANT1(4), CDA(3), CTPS2(2), DCK(2), DCTD(1), DHODH(2), DPYD(6), DPYS(5), DTYMK(1), ENTPD1(4), NT5C(3), NT5E(3), NT5M(1), NUDT2(1), POLB(3), POLD1(3), POLD2(2), POLE(8), POLG(1), POLL(2), POLQ(7), POLR1B(3), POLR2A(9), POLR2B(4), POLR2C(2), POLR2G(1), POLRMT(3), RRM1(3), RRM2(1), TK2(3), TXNRD1(1), UCK1(4), UMPS(1), UPP1(3) 68133374 110 71 109 37 23 20 13 39 15 0 0.489 1.000 1.000 485 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 38 AKT1(2), ASAH1(2), ATF1(1), CREB1(2), CREBBP(13), CRKL(2), DAG1(3), EGR1(5), EGR2(2), EGR3(2), ELK1(5), FRS2(1), MAP1B(10), MAPK1(4), MAPK10(1), MAPK3(2), MAPK8(2), MAPK8IP1(3), MAPK8IP2(4), MAPK8IP3(6), MAPK9(1), NTRK1(3), OPN1LW(1), PIK3C2G(10), PIK3CD(3), RPS6KA3(4), SHC1(1), SRC(2), TERF2IP(1), TH(3) 53545487 101 71 100 30 23 14 19 21 23 1 0.102 1.000 1.000 486 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(1), ACTG2(2), ADCY3(5), ADCY9(11), AK1(1), ARF1(1), ARF6(1), ARL4D(1), ATP6V0A2(1), ATP6V0A4(3), ATP6V0C(1), ATP6V0D1(2), ATP6V0D2(3), ATP6V1A(2), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(1), ATP6V1E2(2), ATP6V1G1(1), ATP6V1G3(2), ATP6V1H(1), ERO1L(1), GNAS(4), PDIA4(3), PLCG1(12), PLCG2(12), PRKCA(6), SEC61A1(1), TRIM23(3) 43932351 88 70 86 32 33 18 9 15 12 1 0.367 1.000 1.000 487 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CD14(1), CHUK(1), ELK1(5), FOS(2), IKBKB(2), IRAK1(3), LY96(2), MAP2K3(6), MAP3K1(9), MAP3K7(3), MAPK8(2), NFKB1(2), NFKBIA(3), PPARA(4), RELA(1), TLR10(7), TLR2(5), TLR3(6), TLR4(2), TLR6(8), TLR7(10), TLR9(5), TOLLIP(1) 43409096 90 70 85 31 29 18 12 21 10 0 0.262 1.000 1.000 488 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 30 AKT1(2), APC(3), AR(4), ASAH1(2), CCL13(1), CCL16(1), DAG1(3), GNA11(1), GNA15(1), GNAI1(4), ITPR1(9), ITPR2(15), ITPR3(18), KCNJ3(2), KCNJ5(5), KCNJ9(1), MAPK1(4), MAPK10(1), PHKA2(5), PIK3CD(3), PITX2(7), PTX3(2), RAF1(2), SRC(2) 54225320 98 68 98 30 25 15 26 19 11 2 0.108 1.000 1.000 489 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 ALDH1A1(2), ALDH1A2(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH4A1(2), AMD1(2), AOC2(1), ARG2(2), ASL(2), CKB(1), CKM(3), CKMT1A(2), CKMT1B(4), CKMT2(1), CPS1(8), DAO(3), GAMT(1), GATM(2), GLUD1(4), GOT1(2), GOT2(1), MAOA(3), MAOB(2), NOS1(10), NOS3(10), OAT(1), ODC1(3), OTC(2), P4HA1(1), P4HB(1), RARS(3), SMS(1) 52591328 98 67 98 37 36 17 11 22 12 0 0.390 1.000 1.000 490 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 92 ANK2(15), CDR1(1), DGKI(2), IL6ST(3), MRPL19(2), RPL10(5), RPL11(2), RPL13A(2), RPL15(2), RPL18A(1), RPL23(1), RPL24(1), RPL29(1), RPL32(1), RPL35(2), RPL36(1), RPL3L(1), RPL6(1), RPL7(3), RPL7A(1), RPLP0(1), RPS11(1), RPS12(2), RPS18(2), RPS19(1), RPS2(1), RPS21(1), RPS24(1), RPS3(3), RPS4X(3), RPS5(1), RPS6KA1(5), RPS6KA2(5), RPS6KA3(4), RPS6KA6(5), RPS6KB1(2), RPS6KB2(3), SLC36A2(3), TBC1D10C(2), TSPAN9(1), UBA52(1), UBC(7) 61564681 103 64 102 29 25 16 13 30 19 0 0.297 1.000 1.000 491 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 37 AKT1(2), ATF2(2), DLD(3), DUSP10(2), DUSP4(1), GCK(2), IL1R1(4), MAP2K5(2), MAP3K1(9), MAP3K10(1), MAP3K12(6), MAP3K13(3), MAP3K3(2), MAP3K4(7), MAP3K5(4), MAP3K7(3), MAP3K9(6), MAPK10(1), MAPK7(6), MAPK8(2), MAPK9(1), MYEF2(3), NFATC3(2), NR2C2(3), PAPPA(6), SHC1(1), ZAK(5) 58881298 89 64 87 30 25 18 16 21 9 0 0.355 1.000 1.000 492 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(6), CARM1(1), CCND1(4), CREBBP(13), EP300(6), ERCC3(2), ESR1(3), GRIP1(9), GTF2E1(3), GTF2F1(1), HDAC2(7), HDAC3(1), HDAC4(4), HDAC5(1), HDAC6(4), NCOR2(9), NR0B1(1), NRIP1(4), PELP1(2), POLR2A(9), TBP(2) 54982332 92 63 91 31 30 13 7 21 21 0 0.396 1.000 1.000 493 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CALM1(1), CALM3(1), CAMK1(2), CAMK1G(1), ELK1(5), FPR1(1), GNA15(1), GNB1(1), MAP2K1(1), MAP2K2(1), MAP2K3(6), MAP3K1(9), MAPK1(4), MAPK3(2), NCF1(3), NCF2(6), NFATC1(2), NFATC2(7), NFATC3(2), NFATC4(5), NFKB1(2), NFKBIA(3), PAK1(3), PIK3C2G(10), PLCB1(4), PPP3CA(1), PPP3CB(1), PPP3CC(1), RAC1(1), RAF1(2), RELA(1), SYT1(2) 45574438 92 63 89 34 27 13 13 17 21 1 0.331 1.000 1.000 494 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 112 ATP12A(7), ATP4A(6), ATP4B(2), ATP5A1(1), ATP5B(3), ATP5G2(1), ATP5I(1), ATP6AP1(3), ATP6V0A2(1), ATP6V0A4(3), ATP6V0C(1), ATP6V0D1(2), ATP6V0D2(3), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(1), ATP6V1E2(2), ATP6V1G1(1), ATP6V1G3(2), ATP6V1H(1), COX10(5), COX15(1), COX17(1), COX6B1(1), COX7A1(1), COX7B2(1), COX7C(1), LHPP(1), NDUFA10(4), NDUFA12(1), NDUFA3(2), NDUFA4(1), NDUFA7(1), NDUFA9(4), NDUFB11(1), NDUFB5(1), NDUFS1(2), NDUFS2(1), NDUFS3(1), NDUFS8(1), NDUFV1(2), NDUFV2(1), PPA2(1), SDHA(4), SDHC(2), TCIRG1(2), UQCRC1(4), UQCRC2(1), UQCRH(2), UQCRQ(1) 66050109 101 63 100 32 25 17 16 26 16 1 0.221 1.000 1.000 495 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 28 AGA(1), FUCA1(6), FUCA2(3), GLB1(2), GUSB(3), HEXA(1), HEXB(1), HGSNAT(3), HPSE(5), HPSE2(5), HYAL1(3), HYAL2(1), IDS(2), LCT(13), MAN2B1(7), MAN2B2(7), MAN2C1(2), MANBA(1), NAGLU(3), NEU1(2), NEU3(2), NEU4(2), SPAM1(7) 40137943 82 62 80 29 31 10 9 23 9 0 0.385 1.000 1.000 496 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 AGXT(2), AGXT2(2), ALAS1(2), ALAS2(1), AMT(3), AOC2(1), ATP6V0C(1), CBS(5), CHKB(1), CTH(2), DAO(3), DLD(3), DMGDH(3), GAMT(1), GARS(3), GATM(2), GCAT(2), GLDC(3), MAOA(3), MAOB(2), PISD(2), PLCB2(7), PLCG1(12), PLCG2(12), PSPH(2), SARDH(3), SARS(1), SHMT1(2), TARS(1) 49994814 87 61 85 30 28 21 5 22 11 0 0.195 1.000 1.000 497 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA1(1), ACAA2(3), ACADL(1), ACADM(2), ACADS(5), ACADVL(3), ACAT2(1), ACOX1(2), ACOX3(3), ACSL1(4), ACSL3(3), ACSL4(6), ACSL6(3), ADH1A(3), ADH1B(4), ADH5(1), ADH6(3), ADH7(2), ADHFE1(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH7A1(2), CPT1A(2), CPT1C(2), CPT2(2), CYP4A11(5), CYP4A22(2), ECHS1(3), EHHADH(2), GCDH(1), HADHA(3), HSD17B4(3) 58123325 95 61 93 40 27 13 8 26 21 0 0.693 1.000 1.000 498 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(2), ARG2(2), ASL(2), ASS1(4), CKB(1), CKM(3), CKMT1A(2), CKMT1B(4), CKMT2(1), CPS1(8), DAO(3), EPRS(5), GAMT(1), GATM(2), GLUD1(4), GLUD2(4), GOT1(2), GOT2(1), LAP3(1), NOS1(10), NOS3(10), OAT(1), OTC(2), P4HA1(1), PARS2(2), PRODH(1), RARS(3), RARS2(4) 42713639 86 61 85 32 32 14 11 20 9 0 0.442 1.000 1.000 499 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 72 B2M(1), CALR(2), CANX(2), CD4(2), CD8A(1), CIITA(4), CREB1(2), CTSB(4), CTSS(1), HLA-A(1), HLA-B(1), HLA-C(1), HLA-DMA(2), HLA-DMB(5), HLA-DOA(2), HLA-DOB(2), HLA-DPB1(1), HLA-DQA1(1), HLA-DQA2(3), HLA-DRA(4), HLA-DRB1(1), HLA-DRB5(1), HLA-E(1), HLA-F(2), HSP90AA1(1), HSP90AB1(3), IFI30(1), IFNA10(2), IFNA5(1), IFNA6(1), IFNA7(1), IFNA8(1), KIR2DL3(3), KIR3DL1(3), KIR3DL2(1), KIR3DL3(1), KLRC1(3), KLRC2(1), KLRC3(4), KLRC4(1), KLRD1(1), LGMN(1), NFYA(1), NFYB(1), PDIA3(1), PSME1(3), RFX5(2), RFXANK(1), TAP1(2), TAP2(1) 54590904 89 61 88 36 20 16 11 24 18 0 0.648 1.000 1.000 500 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 37 AKT1(2), BCR(3), BLNK(2), BTK(3), CD19(2), CSK(2), DAG1(3), EPHB2(5), LYN(2), MAP2K1(1), MAP2K2(1), MAPK1(4), NFAT5(3), NFKB1(2), NFKB2(2), NFKBIA(3), NFKBIE(3), PI3(2), PIK3CD(3), PLCG2(12), PPP1R13B(1), RAF1(2), SERPINA4(2), SHC1(1), SOS1(7), SOS2(5), VAV1(9) 58090348 87 61 87 33 28 16 11 21 11 0 0.374 1.000 1.000 501 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ADH1A(3), ADH1B(4), ADH6(3), ADH7(2), ADHFE1(2), ALDH1A3(5), ALDH3A1(6), ALDH3B2(3), AOC2(1), AOX1(9), DBH(4), DCT(1), DDC(5), FAH(2), GOT1(2), GOT2(1), GSTZ1(3), HGD(5), HPD(1), MAOA(3), MAOB(2), TAT(3), TH(3), TPO(10), TYR(5) 37648718 88 60 85 30 39 9 8 25 7 0 0.175 1.000 1.000 502 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(2), ARHGEF11(4), BCL2(2), DLG4(5), GNA13(1), LPA(11), MAP3K1(9), MAP3K5(4), MAPK8(2), NFKB1(2), NFKB2(2), NFKBIA(3), NFKBIE(3), PDK1(2), PHKA2(5), PI3(2), PIK3CB(7), PLD1(8), PLD3(1), PTK2(2), RDX(5), ROCK1(4), ROCK2(5), SERPINA4(2), SRF(3), TBXA2R(1) 58323241 97 59 95 32 25 21 14 22 14 1 0.307 1.000 1.000 503 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 59 B3GALNT1(2), B3GALT1(2), B3GALT2(1), B3GALT5(2), B3GNT2(1), B3GNT3(4), B3GNT4(2), B3GNT5(4), B4GALNT1(3), B4GALT2(1), B4GALT6(2), FUT2(2), FUT3(2), FUT4(1), FUT5(6), FUT6(3), FUT7(1), GBGT1(2), GCNT2(1), PIGA(3), PIGB(1), PIGC(1), PIGF(1), PIGG(1), PIGN(2), PIGO(5), PIGQ(3), PIGS(2), PIGT(1), PIGU(2), PIGX(1), PIGZ(2), ST3GAL1(3), ST3GAL2(1), ST3GAL3(2), ST3GAL4(3), ST6GALNAC3(3), ST6GALNAC4(1), ST6GALNAC6(1), ST8SIA1(2), ST8SIA5(3), UGCG(2) 56902649 88 58 88 35 31 8 8 28 13 0 0.733 1.000 1.000 504 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 40 APAF1(3), BAK1(2), BAX(1), BCL2(2), BIRC2(3), BIRC3(1), CASP2(1), CASP8(2), CASP9(1), CYCS(2), FAS(1), FASLG(1), GZMB(3), MAP3K1(9), MAPK10(1), MCL1(1), MDM2(5), NFKB1(2), NFKBIA(3), PARP1(3), PRF1(3), RELA(1), RIPK1(4), TNF(1), TNFRSF1A(1), TNFRSF1B(3), TNFSF10(2), TRADD(1), TRAF1(1), TRAF2(2) 43465381 66 57 64 23 18 12 9 16 11 0 0.399 1.000 1.000 505 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR2(2), ACTR3(1), ARHGAP1(1), ARHGAP4(4), ARHGAP5(5), ARHGAP6(4), ARHGEF1(1), ARHGEF11(4), ARHGEF5(3), ARPC1A(1), ARPC1B(2), ARPC2(1), ARPC3(1), ARPC4(1), BAIAP2(3), CFL1(1), DIAPH1(5), GSN(2), LIMK1(4), MYL2(2), MYLK(7), OPHN1(6), PIP5K1B(3), PPP1R12B(1), ROCK1(4), SRC(2), TLN1(5), VCL(1) 54094464 77 57 76 31 18 9 10 27 13 0 0.743 1.000 1.000 506 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(3), AKT1(2), DAG1(3), ITPR1(9), ITPR2(15), ITPR3(18), NFKB1(2), NFKB2(2), NFKBIA(3), NFKBIE(3), PDK1(2), PHKA2(5), PIK3CB(7), PITX2(7), PLD1(8), PLD3(1) 53359498 90 57 90 33 28 17 14 22 7 2 0.297 1.000 1.000 507 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 23 ARNT(1), EIF2B1(1), EIF2B4(1), EIF2S2(2), EIF2S3(3), ELAVL1(1), FLT1(10), FLT4(8), KDR(14), NOS3(10), PLCG1(12), PRKCA(6), PTK2(2), PXN(1), SHC1(1) 35968174 73 57 71 30 20 12 11 18 11 1 0.631 1.000 1.000 508 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 46 AADAT(1), AASDHPPT(1), AASS(1), ACAT2(1), AKR1B10(3), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH7A1(2), DOT1L(4), ECHS1(3), EHHADH(2), EHMT1(5), EHMT2(5), GCDH(1), HADHA(3), HSD17B4(3), HSD3B7(1), NSD1(5), OGDH(1), OGDHL(7), PLOD1(3), PLOD2(2), PLOD3(1), SETD1A(4), SETD7(2), SETDB1(8), SHMT1(2), SUV39H1(2), SUV39H2(1), TMLHE(2) 68075181 92 55 92 43 35 12 9 23 13 0 0.837 1.000 1.000 509 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1C4(2), AKR1D1(1), ARSD(3), ARSE(6), CYP11B1(2), CYP11B2(3), HSD11B1(2), HSD17B3(1), HSD17B8(1), HSD3B1(2), HSD3B2(1), SRD5A1(2), STS(2), SULT2A1(2), UGT1A1(5), UGT1A10(2), UGT1A3(3), UGT1A4(1), UGT1A5(3), UGT1A6(4), UGT1A7(3), UGT1A9(2), UGT2B15(3), UGT2B4(9) 32485666 65 52 64 26 23 12 9 15 6 0 0.392 1.000 1.000 510 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(3), BAX(1), BCL2(2), BCL2A1(1), BCL2L2(1), BOK(1), CASP1(6), CASP10(1), CASP2(1), CASP4(1), CASP8(2), CASP9(1), CD40(1), CD40LG(2), CRADD(2), CYCS(2), DAXX(5), DFFA(2), FAS(1), FASLG(1), IKBKE(5), MCL1(1), NFKB1(2), NFKBIA(3), NGFR(1), NR3C1(3), NTRK1(3), PTPN13(4), RIPK1(4), TFG(1), TNF(1), TNFRSF1A(1), TNFRSF1B(3), TRADD(1), TRAF1(1), TRAF2(2), TRAF3(1) 51772317 74 52 74 29 21 12 5 18 18 0 0.681 1.000 1.000 511 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(19), C5(7), C6(4), C7(5), ICAM1(3), IL1A(1), IL6(2), ITGA4(8), ITGAL(2), ITGB1(3), ITGB2(5), SELP(4), SELPLG(3), TNF(1), VCAM1(2) 29462150 69 52 69 32 20 9 10 18 12 0 0.733 1.000 1.000 512 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(1), CDC7(2), CDK2(1), DIAPH2(5), GMNN(1), MCM10(4), MCM2(1), MCM3(3), MCM4(5), MCM5(3), MCM6(6), MCM7(6), NACA(6), POLA2(2), POLD1(3), POLD2(2), POLD3(2), POLD4(1), POLE(8), POLE2(1), PRIM1(2), RFC1(2), RFC4(4), RPA1(3), RPA2(1), RPA4(2), UBA52(1), UBC(7) 60300898 85 51 85 35 14 12 11 30 18 0 0.805 1.000 1.000 513 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 21 BCAR1(3), CXCR4(2), GNAI1(4), GNB1(1), MAP2K1(1), MAPK1(4), MAPK3(2), NFKB1(2), PIK3C2G(10), PLCG1(12), PRKCA(6), PTK2(2), PTK2B(5), PXN(1), RAF1(2), RELA(1) 28414196 58 50 56 22 17 5 13 11 10 2 0.523 1.000 1.000 514 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 44 AGXT(2), AGXT2(2), AKR1B10(3), ALAS1(2), ALAS2(1), AMT(3), AOC2(1), CBS(5), CHKB(1), CTH(2), DAO(3), DLD(3), DMGDH(3), GAMT(1), GARS(3), GATM(2), GCAT(2), GLDC(3), HSD3B7(1), MAOA(3), MAOB(2), PHGDH(5), PISD(2), PSAT1(4), PSPH(2), SARDH(3), SARS(1), SARS2(2), SDS(1), SHMT1(2), TARS(1), TARS2(2) 49828383 73 50 73 24 22 19 5 19 8 0 0.179 1.000 1.000 515 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 19 ADCYAP1R1(5), CALCRL(1), CD97(3), CRHR2(5), ELTD1(6), EMR1(5), EMR2(6), GHRHR(3), GIPR(2), GLP1R(2), GLP2R(3), GPR64(4), LPHN1(2), LPHN2(8), LPHN3(7), SCTR(1), VIPR1(1), VIPR2(2) 30616739 66 49 65 29 19 7 13 22 5 0 0.766 1.000 1.000 516 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(3), AARS2(1), DARS(1), DARS2(2), EARS2(1), EPRS(5), FARS2(3), FARSA(1), GARS(3), HARS(4), HARS2(1), IARS(4), IARS2(3), KARS(2), LARS(4), MARS(7), MARS2(2), MTFMT(1), NARS(1), NARS2(1), PARS2(2), QARS(5), RARS(3), RARS2(4), SARS(1), SARS2(2), TARS(1), TARS2(2), VARS(4), VARS2(3), WARS(1), WARS2(2), YARS(1), YARS2(1) 64422010 82 48 82 23 11 18 11 29 13 0 0.339 1.000 1.000 517 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(3), ANAPC10(1), ANAPC2(2), ANAPC4(2), ANAPC5(4), ANAPC7(2), BTRC(2), CDC16(2), CDC20(1), CDC23(4), CDC27(5), CUL1(4), CUL2(7), CUL3(1), FBXW11(1), FBXW7(5), FZR1(4), ITCH(1), RBX1(1), SKP2(3), SMURF1(4), SMURF2(2), UBE2D4(2), UBE2E3(1), WWP1(3), WWP2(2) 47872334 69 47 69 28 16 8 13 21 11 0 0.829 1.000 1.000 518 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(7), APOA1(1), APOA4(3), APOE(2), CETP(3), CYP7A1(3), DGAT1(2), LCAT(1), LDLR(3), LIPC(1), LPL(2), LRP1(29), SCARB1(1), SOAT1(5) 32505871 63 47 63 25 15 10 5 20 13 0 0.694 1.000 1.000 519 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(6), GABBR1(2), GPRC5C(1), GPRC5D(2), GRM1(6), GRM2(4), GRM3(16), GRM4(6), GRM5(6), GRM7(5), GRM8(7) 24925941 61 46 59 40 33 5 3 15 5 0 0.978 1.000 1.000 520 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(2), ATF1(1), CREB1(2), DUSP1(1), DUSP10(2), EEF2K(2), EIF4E(2), ELK1(5), IL1R1(4), MAP2K3(6), MAP3K10(1), MAP3K4(7), MAP3K5(4), MAP3K7(3), MAPK1(4), MAPK12(2), MAPK13(2), MAPKAPK2(2), MAPKAPK5(2), MKNK1(2), MYEF2(3), NFKB1(2), NR2C2(3), SRF(3) 39621956 67 46 67 24 18 10 15 14 10 0 0.421 1.000 1.000 521 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1QA(2), C1QB(1), C1R(2), C1S(5), C2(7), C3(19), C5(7), C6(4), C7(5), C8A(4), C8B(7), C9(2), MASP1(2) 24743881 67 45 67 27 25 10 4 19 9 0 0.592 1.000 1.000 522 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(1), ALG10B(3), ALG12(2), ALG13(4), ALG14(1), ALG3(4), ALG5(3), ALG6(3), B4GALT2(1), DAD1(1), DHDDS(1), DPAGT1(2), DPM1(3), FUT8(7), GANAB(4), MAN1A1(3), MAN1A2(1), MAN1B1(1), MAN1C1(2), MAN2A1(4), MGAT1(3), MGAT2(3), MGAT3(3), MGAT4A(1), MGAT5(2), MGAT5B(2), RPN1(1), RPN2(1), ST6GAL1(2), STT3B(2) 50341004 71 44 71 23 17 19 9 10 16 0 0.255 1.000 1.000 523 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA1(1), ACAA2(3), ACAD8(4), ACAD9(1), ADH1A(3), ADH1B(4), ADH5(1), ADH6(3), ADH7(2), ADHFE1(2), AKR1B10(3), AKR1C4(2), AKR1D1(1), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH7A1(2), BAAT(1), CEL(4), CYP27A1(2), CYP7A1(3), HSD3B7(1), LIPA(2), SLC27A5(4), SOAT1(5), SOAT2(2), SRD5A1(2) 37576345 74 43 74 31 19 11 8 29 7 0 0.762 1.000 1.000 524 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCL3(1), CCR1(1), CCR2(2), CCR3(2), CCR4(2), CCR5(1), CCR7(1), CD28(2), CD4(2), CSF2(2), CXCR4(2), IFNG(2), IFNGR1(1), IFNGR2(4), IL12B(4), IL12RB1(4), IL12RB2(4), IL18R1(4), IL4R(10), IL5(1), TGFB2(2), TGFB3(1) 23771415 55 43 54 23 20 3 8 16 8 0 0.601 1.000 1.000 525 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(3), AXIN1(4), CREBBP(13), CTNNB1(3), DVL1(1), EP300(6), FZD1(3), GSK3B(1), LDB1(2), LEF1(1), PITX2(7), TRRAP(18), WNT1(1) 39411320 63 43 63 25 16 9 9 16 13 0 0.680 1.000 1.000 526 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 32 AKT1(2), BCL2(2), CBL(2), CFLAR(1), CRKL(2), E2F1(1), FOS(2), IL2RB(2), IRS1(8), JAK1(3), JAK3(5), MAPK1(4), MAPK3(2), PTPN6(1), RAF1(2), RPS6KB1(2), SHC1(1), SOCS1(1), SOS1(7), STAT5A(1), STAT5B(2) 38525376 53 42 53 22 11 8 7 13 13 1 0.757 1.000 1.000 527 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTN1(3), ACTN2(6), BCAR1(3), BCR(3), CAPN1(2), CAPNS1(2), CAPNS2(1), CRKL(2), CSK(2), FYN(2), ITGA1(4), ITGB1(3), MAP2K1(1), MAP2K2(1), MAPK1(4), MAPK3(2), MAPK8(2), PPP1R12B(1), PTK2(2), PXN(1), RAF1(2), ROCK1(4), SHC1(1), SOS1(7), SRC(2), TLN1(5), VCL(1), ZYX(2) 56050622 71 42 71 19 22 10 14 16 8 1 0.0867 1.000 1.000 528 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 17 CBL(2), EGF(10), MAP2K1(1), MAPK1(4), MAPK3(2), PTPRB(9), RAF1(2), RASA1(4), SHC1(1), SOS1(7), SPRY1(1), SPRY2(3), SPRY3(3), SPRY4(3), SRC(2) 26493380 54 42 54 19 14 3 7 15 14 1 0.615 1.000 1.000 529 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B10(3), ALDOA(1), ALDOB(2), FBP1(3), FBP2(2), FPGT(3), GMDS(1), GMPPA(2), HK1(4), HK2(5), HK3(5), HSD3B7(1), LHPP(1), MPI(1), MTMR1(6), MTMR2(3), MTMR6(1), PFKFB1(6), PFKFB2(2), PFKFB3(2), PFKFB4(1), PFKL(5), PFKP(1), PGM2(4), PMM1(1), SORD(1), TPI1(1), TSTA3(1) 44206222 69 41 69 25 29 12 6 13 9 0 0.296 1.000 1.000 530 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1QA(2), C1QB(1), C1R(2), C1S(5), C2(7), C3(19), C5(7), C6(4), C7(5), C8A(4), C9(2) 20838544 58 40 58 22 22 5 4 18 9 0 0.588 1.000 1.000 531 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 14 AGA(1), FUCA1(6), FUCA2(3), GLB1(2), HEXA(1), HEXB(1), LCT(13), MAN2B1(7), MAN2B2(7), MAN2C1(2), MANBA(1), NEU1(2), NEU3(2), NEU4(2) 23341016 50 39 50 21 16 6 6 16 6 0 0.693 1.000 1.000 532 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(6), ICAM1(3), ITGA4(8), ITGAL(2), ITGAM(7), ITGB1(3), ITGB2(5), SELE(8), SELP(4) 18965826 46 39 45 25 18 5 10 8 5 0 0.809 1.000 1.000 533 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA1(1), ACAA2(3), ADH1A(3), ADH1B(4), ADH6(3), ADH7(2), ADHFE1(2), AKR1C4(2), AKR1D1(1), ALDH1A1(2), ALDH1A2(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), BAAT(1), CEL(4), CYP27A1(2), CYP7A1(3), SOAT2(2), SRD5A1(2) 27602759 55 38 55 24 17 9 5 19 5 0 0.692 1.000 1.000 534 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH7A1(2), AMD1(2), AOC2(1), ARG2(2), ASL(2), ASS1(4), CPS1(8), GATM(2), MAOA(3), MAOB(2), NAGS(1), ODC1(3), OTC(2), SMS(1), SRM(2) 35038014 53 38 52 20 19 6 6 13 9 0 0.595 1.000 1.000 535 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA1(2), ANXA2(2), ANXA3(3), ANXA5(1), ANXA6(3), CYP11A1(7), EDNRA(1), EDNRB(1), HPGD(1), HSD11B1(2), PLA2G4A(7), PRL(1), PTGER4(2), PTGFR(7), PTGIS(2), PTGS1(3), PTGS2(3), SCGB1A1(1), TBXAS1(2) 24524396 51 38 51 21 16 5 4 16 10 0 0.673 1.000 1.000 536 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 CEBPB(2), CLOCK(3), CRY1(3), DNAJA1(3), EIF4G2(1), ETV6(4), GFRA1(1), HERPUD1(2), HSPA8(3), IDI1(2), KLF9(3), MYF6(2), NCKAP1(5), NCOA4(3), NR1D2(1), PER1(6), PER2(6), PIGF(1), PPP1R3C(1), PPP2CB(1), PSMA4(1), PURA(1), SF3A3(2), TOB1(1), UGP2(1), ZFR(3) 43503986 62 37 61 21 14 11 9 21 7 0 0.542 1.000 1.000 537 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 23 CAPN1(2), CAPNS1(2), CAPNS2(1), EGF(10), ITGA1(4), ITGB1(3), MAPK1(4), MAPK3(2), MYL2(2), MYLK(7), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), PTK2(2), PXN(1), TLN1(5) 35740505 50 37 50 21 18 2 10 13 6 1 0.724 1.000 1.000 538 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 CHUK(1), IKBKB(2), IL1A(1), IL1R1(4), IRAK1(3), MAP3K1(9), MAP3K7(3), NFKB1(2), NFKBIA(3), RELA(1), RIPK1(4), TLR4(2), TNF(1), TNFAIP3(2), TNFRSF1A(1), TNFRSF1B(3), TRADD(1) 28972291 43 37 41 20 15 12 4 6 6 0 0.693 1.000 1.000 539 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 17 ADCY1(5), ARHGEF1(1), F2(4), F2R(2), F2RL3(3), GNA13(1), GNAI1(4), GNB1(1), MAP3K7(3), PLCB1(4), PPP1R12B(1), PRKCA(6), PTK2B(5), ROCK1(4) 26265063 44 37 44 19 14 6 6 10 7 1 0.657 1.000 1.000 540 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 30 DUSP1(1), MAPK1(4), MAPK10(1), MAPK12(2), MAPK13(2), MAPK3(2), MAPK8(2), MAPK8IP1(3), MAPK8IP2(4), MAPK8IP3(6), MAPK9(1), MAPKAPK5(2), NFKB1(2), NFKB2(2), NFKBIA(3), NFKBIE(3), PIK3CD(3), SYT1(2), TRAF2(2), TRAF3(1), TRAF5(3) 35471100 51 37 51 18 16 8 9 9 8 1 0.313 1.000 1.000 541 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(3), BCL2(2), BIRC2(3), BIRC3(1), CASP10(1), CASP8(2), CASP9(1), CFLAR(1), CHUK(1), CYCS(2), DFFA(2), GAS2(1), LMNA(2), NFKB1(2), NFKBIA(3), RELA(1), RIPK1(4), SPTAN1(8), TNFRSF25(2), TNFSF10(2), TRADD(1), TRAF2(2) 39721073 47 36 47 15 13 7 5 14 8 0 0.411 1.000 1.000 542 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(3), POLA2(2), POLB(3), POLD1(3), POLD2(2), POLD3(2), POLD4(1), POLE(8), POLE2(1), POLG(1), POLH(1), POLI(5), POLK(2), POLL(2), POLM(3), POLQ(7), PRIM1(2), PRIM2(1), REV1(5), REV3L(8) 48288701 62 36 62 22 16 8 7 21 10 0 0.748 1.000 1.000 543 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 29 ACO2(4), DLD(3), FH(1), IDH3A(1), IDH3B(1), OGDH(1), PC(4), PDHA1(6), PDHA2(7), PDHB(1), PDK1(2), PDK3(3), PDK4(2), PDP2(3), SDHA(4), SDHC(2), SUCLA2(1), SUCLG1(2), SUCLG2(1) 32786073 49 36 46 19 10 12 7 13 7 0 0.500 1.000 1.000 544 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AADAT(1), AASDH(3), AASDHPPT(1), AASS(1), ACAT2(1), ALDH1A1(2), ALDH1A2(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ATP6V0C(1), DOT1L(4), ECHS1(3), EHHADH(2), EHMT1(5), EHMT2(5), GCDH(1), HADHA(3), PLOD1(3), PLOD2(2), PLOD3(1), SDS(1), SHMT1(2), TMLHE(2) 44051689 62 36 62 32 26 10 7 10 9 0 0.794 1.000 1.000 545 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 ATF1(1), CASP2(1), CHUK(1), CRADD(2), IKBKB(2), MAP2K3(6), MAP3K1(9), MAP4K2(1), MAPK8(2), NFKB1(2), NFKBIA(3), RELA(1), RIPK1(4), TANK(3), TNF(1), TNFRSF1A(1), TRADD(1), TRAF2(2) 28720723 43 36 41 20 14 11 3 7 8 0 0.748 1.000 1.000 546 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(1), ACADL(1), ACADM(2), ALDH1A1(2), ALDH1A2(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), AOC2(1), CNDP1(4), DPYD(6), DPYS(5), ECHS1(3), EHHADH(2), GAD1(3), GAD2(1), HADHA(3), MLYCD(4), SDS(1), SMS(1) 34500000 58 35 57 24 19 11 3 16 9 0 0.577 1.000 1.000 547 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOA(1), ALDOB(2), DERA(1), FBP1(3), FBP2(2), G6PD(3), GPI(2), H6PD(3), PFKL(5), PFKP(1), PGD(1), PGLS(1), PGM1(1), PGM3(1), PRPS1(1), PRPS1L1(3), PRPS2(5), RBKS(1), RPE(1), RPIA(1), TALDO1(2), TKT(2), TKTL1(1), TKTL2(3) 28876038 47 35 47 21 20 9 2 7 9 0 0.540 1.000 1.000 548 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(2), CHUK(1), IFNG(2), IKBKB(2), MAP3K1(9), MAP3K5(4), MAP4K5(1), MAPK8(2), NFKB1(2), NFKBIA(3), RELA(1), TNFRSF9(4), TNFSF9(5), TRAF2(2) 23034618 40 34 35 16 11 8 6 3 12 0 0.604 1.000 1.000 549 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 9 EGF(10), MAP2K1(1), MAP3K1(9), NCOR2(9), RXRA(4), THRA(3), THRB(2) 17395120 38 34 34 15 12 8 2 7 9 0 0.642 1.000 1.000 550 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 14 BCL2(2), CREBBP(13), EP300(6), FYN(2), IL7(1), IL7R(3), JAK1(3), JAK3(5), LCK(1), PTK2B(5), STAT5A(1), STAT5B(2) 28818193 44 34 44 18 10 7 5 12 10 0 0.748 1.000 1.000 551 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 15 ADAM12(1), AGT(3), AGTR2(4), EDNRA(1), EDNRB(1), EGF(10), FOS(2), NFKB1(2), PLCG1(12), PRKCA(6), RELA(1) 21212030 43 33 41 19 12 6 5 16 3 1 0.789 1.000 1.000 552 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM1(1), CALM3(1), CCL2(1), CCR5(1), CXCR4(2), FOS(2), MAPK8(2), PLCG1(12), PRKCA(6), PTK2B(5), SYT1(2) 16358037 35 32 33 14 8 7 7 7 5 1 0.452 1.000 1.000 553 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(2), GTF2E1(3), GTF2F1(1), HDAC3(1), NCOA1(3), NCOA2(5), NCOA3(4), NCOR2(9), POLR2A(9), RXRA(4), TBP(2) 29674222 43 32 42 24 7 7 1 14 14 0 0.974 1.000 1.000 554 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 CCNH(2), CDK7(1), ERCC3(2), GTF2A2(1), GTF2E1(3), GTF2H1(3), GTF2H4(2), ILK(1), POLR1A(7), POLR1B(3), POLR2A(9), POLR2B(4), POLR2C(2), POLR2G(1), POLR3B(3), POLR3D(1), POLR3E(1), POLR3K(1), TAF6(1), TAF7(1), TAF9(2), TBP(2) 41585824 53 32 53 31 12 10 6 18 7 0 0.982 1.000 1.000 555 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 22 ARSA(1), ARSD(3), ARSE(6), ASAH1(2), GAL3ST1(2), GALC(1), GLA(2), GLB1(2), LCT(13), NEU1(2), NEU3(2), NEU4(2), PPAP2A(2), PPAP2C(1), SMPD1(1), SMPD2(1), SPTLC1(2), SPTLC2(2), UGCG(2) 27920734 49 31 49 20 18 6 8 14 2 1 0.604 1.000 1.000 556 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(3), EXT2(3), EXTL1(4), EXTL2(2), EXTL3(1), HS3ST1(3), HS3ST3A1(3), HS6ST2(4), HS6ST3(1), NDST1(2), NDST2(2), NDST3(4), NDST4(8) 24655154 40 31 39 16 17 2 9 9 3 0 0.589 1.000 1.000 557 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(2), ELK1(5), FOS(2), IL2RB(2), JAK1(3), JAK3(5), LCK(1), MAP2K1(1), MAPK3(2), MAPK8(2), RAF1(2), SHC1(1), SOS1(7), STAT5A(1), STAT5B(2) 27812961 38 31 38 17 7 7 4 11 8 1 0.751 1.000 1.000 558 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(6), ICAM1(3), ITGA4(8), ITGAL(2), ITGB1(3), ITGB2(5), SELE(8) 14402972 35 31 34 19 13 5 8 4 5 0 0.755 1.000 1.000 559 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BAG4(1), BIRC2(3), BIRC3(1), CASP8(2), CFLAR(1), MAP3K3(2), MAP3K7(3), NFKB1(2), NFKB2(2), NFKBIA(3), NFKBIE(3), NR2C2(3), RALBP1(3), RIPK1(4), TNF(1), TNFAIP3(2), TNFRSF1A(1), TNFRSF1B(3), TRADD(1), TRAF2(2) 32344243 43 31 43 16 14 8 6 9 6 0 0.541 1.000 1.000 560 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 CHUK(1), DUSP1(1), IKBKAP(3), IKBKB(2), MAP3K1(9), NFKB1(2), NFKBIA(3), RELA(1), RIPK1(4), TANK(3), TNFAIP3(2), TNFRSF1B(3), TRAF1(1), TRAF2(2), TRAF3(1) 26666594 38 31 36 16 15 8 2 7 6 0 0.559 1.000 1.000 561 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(19), C5(7), C6(4), C7(5), C8A(4), C9(2) 14944859 41 30 41 19 14 3 4 12 8 0 0.812 1.000 1.000 562 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CR1(5), CR2(8), HLA-DRA(4), HLA-DRB1(1), ICAM1(3), ITGAL(2), ITGB2(5), PTPRC(9) 18066385 37 30 37 19 14 7 1 8 7 0 0.816 1.000 1.000 563 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(2), AP2A1(1), AP2M1(1), ARF1(1), BTK(3), EEA1(3), GRASP(1), GSK3B(1), LYN(2), PFKL(5), PFKP(1), PLCG1(12), PRKCE(1), RAC1(1), RPS6KB1(2), VAV2(4) 29672394 41 30 39 20 10 10 6 8 7 0 0.729 1.000 1.000 564 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B4GALNT1(3), GLB1(2), HEXA(1), HEXB(1), LCT(13), SLC33A1(4), ST3GAL1(3), ST3GAL2(1), ST6GALNAC3(3), ST6GALNAC4(1), ST6GALNAC6(1), ST8SIA1(2), ST8SIA5(3) 19559789 38 27 38 17 14 3 4 8 9 0 0.857 1.000 1.000 565 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(6), ICAM1(3), ITGAL(2), ITGAM(7), ITGB2(5), SELE(8) 12373445 31 27 30 19 15 4 5 3 4 0 0.820 1.000 1.000 566 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 ALDOA(1), ALDOB(2), FBP1(3), FBP2(2), FPGT(3), GCK(2), GMDS(1), GMPPA(2), HK1(4), HK2(5), HK3(5), MPI(1), PFKFB1(6), PFKFB3(2), PFKFB4(1), PFKP(1), PMM1(1), SORD(1), TPI1(1) 28424515 44 26 44 17 18 11 2 8 5 0 0.294 1.000 1.000 567 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOA(1), ALDOB(2), FBP1(3), FBP2(2), G6PD(3), GPI(2), H6PD(3), PFKP(1), PGD(1), PGLS(1), PGM1(1), PGM3(1), PRPS1(1), PRPS1L1(3), PRPS2(5), RBKS(1), RPE(1), RPIA(1), TAL1(1), TALDO1(2), TKT(2) 24255598 38 26 38 19 14 9 2 6 7 0 0.650 1.000 1.000 568 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 DAB1(3), FYN(2), LRP8(1), RELN(25), VLDLR(2) 16639277 33 26 33 20 12 7 5 4 5 0 0.853 1.000 1.000 569 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(3), ESR2(6), PDE1A(3), PDE1B(2), PLCB1(4), PLCB2(7), PRL(1), TRH(1), VIP(2) 13203068 29 26 29 12 9 7 0 8 5 0 0.671 1.000 1.000 570 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 28 ANPEP(5), G6PD(3), GCLC(1), GGT1(3), GPX2(2), GPX5(1), GSS(2), GSTA1(3), GSTA2(1), GSTA3(1), GSTA4(3), GSTM4(1), GSTM5(1), GSTT1(1), GSTZ1(3), PGD(1) 19526385 32 25 32 13 9 7 6 5 5 0 0.574 1.000 1.000 571 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT2(1), B3GNT7(2), B4GALT2(1), CHST1(2), CHST2(2), CHST4(2), CHST6(2), FUT8(7), ST3GAL1(3), ST3GAL2(1), ST3GAL3(2), ST3GAL4(3) 14826172 28 25 28 11 12 4 5 4 3 0 0.496 1.000 1.000 572 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(7), POLR1B(3), POLR2A(9), POLR2B(4), POLR2C(2), POLR2G(1), POLR3A(7), POLR3B(3), POLR3G(1), POLR3GL(1), POLR3K(1) 27852536 39 25 39 14 10 6 7 11 5 0 0.505 1.000 1.000 573 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL22(2), IL22RA1(1), JAK1(3), JAK2(5), JAK3(5), STAT1(4), STAT3(3), STAT5A(1), STAT5B(2), TYK2(10) 21916241 36 25 36 15 12 1 2 14 6 1 0.750 1.000 1.000 574 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 10 DNM1(1), GABRA2(3), GABRA3(4), GABRA4(10), GABRA5(4), GPHN(1), NSF(2), SRC(2), UBQLN1(2) 11981990 29 24 29 13 4 8 5 7 5 0 0.762 1.000 1.000 575 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 20 B3GNT2(1), B3GNT3(4), B3GNT4(2), B3GNT5(4), B4GALT2(1), FUT2(2), FUT3(2), FUT4(1), FUT5(6), FUT6(3), FUT7(1), GCNT2(1), ST8SIA1(2) 18399909 30 24 30 15 11 3 3 8 5 0 0.876 1.000 1.000 576 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOA(1), ALDOB(2), FBP1(3), FBP2(2), GOT1(2), GOT2(1), ME1(2), ME3(1), PGK1(3), PGK2(1), PKLR(4), RPE(1), RPIA(1), TKT(2), TKTL1(1), TKTL2(3), TPI1(1) 23926747 31 24 31 18 10 6 1 10 4 0 0.939 1.000 1.000 577 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 CBS(5), CTH(2), DNMT1(4), DNMT3A(11), DNMT3B(4), MARS(7), MARS2(2), MAT1A(2), MTR(2) 20673971 39 24 39 15 9 8 2 11 7 2 0.479 1.000 1.000 578 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(5), ARHGEF1(1), GNA13(1), GNB1(1), MYL2(2), MYLK(7), PLCB1(4), PPP1R12B(1), PRKCA(6), ROCK1(4) 24524358 32 24 31 18 10 3 4 10 4 1 0.930 1.000 1.000 579 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(1), CD28(2), CD3D(1), CD3E(2), CD3G(1), CD8A(1), ICAM1(3), ITGAL(2), ITGB2(5), PTPRC(9) 12760398 27 24 26 19 12 4 1 6 4 0 0.951 1.000 1.000 580 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(1), CD28(2), CD3D(1), CD3E(2), CD3G(1), CD4(2), ICAM1(3), ITGAL(2), ITGB2(5), PTPRC(9) 13391547 28 24 27 19 12 4 1 7 4 0 0.948 1.000 1.000 581 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 BNIP1(2), GOSR2(1), SNAP29(1), STX11(2), STX16(1), STX5(1), STX6(1), STX7(1), TSNARE1(4), USE1(3), VAMP4(1), VAMP5(3), VAMP7(3), VAMP8(1), VTI1A(2) 19867381 27 23 26 13 9 3 6 5 4 0 0.773 1.000 1.000 582 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(3), PLCG1(12), PRKCA(6), PTK2B(5) 7994338 26 23 24 13 9 4 3 6 3 1 0.735 1.000 1.000 583 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 14 AKT1(2), BPNT1(1), ILK(1), MAPK1(4), MAPK3(2), PDK1(2), PIK3CD(3), PTK2B(5), RBL2(3), SHC1(1), SOS1(7) 20654038 31 23 31 12 7 5 3 11 4 1 0.579 1.000 1.000 584 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 CISH(1), JAK1(3), JAK2(5), JAK3(5), PIAS1(2), PIAS3(3), PTPRU(3), REG1A(2), SOAT1(5) 16359794 29 23 29 11 5 3 3 10 8 0 0.709 1.000 1.000 585 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX12(1), ALOX15(2), ALOX15B(1), ALOX5(2), ALOX5AP(1), DPEP1(2), GGT1(3), LTA4H(4), PLA2G6(3), PTGES(1), PTGIS(2), PTGS1(3), PTGS2(3), TBXAS1(2) 17885423 30 22 30 14 10 8 2 4 6 0 0.663 1.000 1.000 586 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOA(1), ALDOB(2), FBP1(3), FBP2(2), GOT1(2), GOT2(1), ME1(2), ME2(2), ME3(1), PGK1(3), PKLR(4), RPE(1), RPIA(1), TKT(2), TPI1(1) 21403975 28 21 28 14 8 6 1 10 3 0 0.846 1.000 1.000 587 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 13 AKT1(2), CREB1(2), MAP2K1(1), MAP2K2(1), MAP2K3(6), MAP3K1(9), MAPK1(4), MAPK3(2), NFKB1(2), RELA(1), SP1(1) 16521618 31 21 29 11 11 7 4 2 6 1 0.397 1.000 1.000 588 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(2), CYP51A1(2), DHCR24(2), DHCR7(4), FDFT1(1), FDPS(3), GGCX(1), GGPS1(1), HSD17B7(2), IDI1(2), IDI2(1), LSS(1), MVD(4), MVK(1), NQO1(1), NSDHL(2), SQLE(1) 22923525 31 21 30 12 9 4 7 8 3 0 0.638 1.000 1.000 589 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(2), ALDH1A2(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ECHS1(3), EHHADH(2), HADHA(3), SDS(1) 14437041 29 21 29 14 12 5 3 4 5 0 0.612 1.000 1.000 590 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 CHUK(1), DUSP1(1), IKBKAP(3), IKBKB(2), MAP3K1(9), NFKB1(2), NFKBIA(3), RELA(1), TNFAIP3(2), TRAF3(1) 21553197 25 20 23 12 9 6 2 5 3 0 0.704 1.000 1.000 591 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CSNK1D(2), DRD1(1), DRD2(1), GRM1(6), PLCB1(4), PPP1CA(1), PPP1R1B(1), PPP2CA(4), PPP3CA(1), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1) 19058977 26 19 26 11 9 3 1 10 3 0 0.797 1.000 1.000 592 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(1), CD3D(1), CD3E(2), CD3G(1), GZMB(3), HLA-A(1), ICAM1(3), ITGAL(2), ITGB2(5), PRF1(3) 10373523 22 19 22 13 11 2 2 2 5 0 0.783 1.000 1.000 593 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(2), CYSLTR2(2), GPR161(3), GPR171(1), GPR18(2), GPR34(4), GPR45(4), GPR65(2), GPR68(1), GPR75(2) 11685644 23 18 23 11 7 3 4 3 6 0 0.639 1.000 1.000 594 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(1), ASPH(3), CREB1(2), EP300(6), EPO(2), LDHA(1), NOS3(10), P4HB(1) 20239599 26 18 26 13 11 2 2 8 3 0 0.836 1.000 1.000 595 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(4), ACAD9(1), ADH1A(3), ADH1B(4), ADH5(1), ADH6(3), ADH7(2), ADHFE1(2), DHRS2(2), DHRS3(1), DHRS7(1), DHRSX(1), ESCO1(2), ESCO2(2), PNPLA3(1), SH3GLB1(3) 29663005 33 18 32 13 7 7 2 16 1 0 0.723 1.000 1.000 596 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT2(1), ACOT11(3), ACYP1(1), DHRS2(2), DHRS3(1), DHRS7(1), DHRSX(1), ECHS1(3), EHHADH(2), ESCO1(2), ESCO2(2), GCDH(1), HADHA(3), PNPLA3(1), SH3GLB1(3), YOD1(1) 30823071 28 17 27 11 9 8 3 4 4 0 0.524 1.000 1.000 597 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(4), DHFR(1), HPRT1(1), IMPDH1(5), OAZ1(1), POLB(3), POLD1(3), POLG(1), PRPS2(5), RRM1(3), SRM(2) 14853006 29 17 29 12 11 5 5 5 3 0 0.537 1.000 1.000 598 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 17 ACTR2(2), ACTR3(1), ARPC1A(1), ARPC1B(2), ARPC2(1), ARPC3(1), ARPC4(1), NCKAP1(5), NTRK1(3), RAC1(1), WASF1(1), WASF2(1), WASF3(4), WASL(2) 17217633 26 16 26 10 3 4 4 9 6 0 0.722 1.000 1.000 599 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 GLB1(2), GUSB(3), HEXA(1), HEXB(1), IDS(2), LCT(13), NAGLU(3) 17105985 25 16 25 11 10 3 4 4 4 0 0.674 1.000 1.000 600 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(2), FOSL2(2), IFNAR1(2), IFNAR2(2), IFNB1(2), MAPK8(2), NFKB1(2), RELA(1), TNFRSF11A(5), TNFSF11(1) 13172312 21 16 21 12 4 6 2 7 2 0 0.870 1.000 1.000 601 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 CLOCK(3), CRY1(3), CSNK1D(2), CSNK1E(1), NPAS2(1), NR1D1(1), PER1(6), PER2(6), PER3(2) 20310019 25 15 24 13 6 7 1 9 2 0 0.898 1.000 1.000 602 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(2), HMOX1(1), IL10(1), IL10RB(1), IL1A(1), IL6(2), JAK1(3), STAT1(4), STAT3(3), STAT5A(1), TNF(1) 14452722 20 15 20 10 4 3 2 8 2 1 0.788 1.000 1.000 603 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(3), POLD1(3), POLD2(2), POLE(8), POLG(1), POLL(2), POLQ(7) 19793532 26 14 26 15 9 3 2 11 1 0 0.953 1.000 1.000 604 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACAA1(1), ACOX1(2), ACOX3(3), ELOVL2(2), ELOVL6(1), FADS2(2), FASN(3), HADHA(3), PECR(2), SCD(1) 17075150 20 14 20 17 4 5 2 7 2 0 0.984 1.000 1.000 605 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARF1(1), ARFGEF2(6), CLTA(1), COPA(2), GBF1(4), GPLD1(1), KDELR1(2), KDELR2(1), KDELR3(1) 19247103 19 13 19 10 4 6 3 3 3 0 0.799 1.000 1.000 606 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 C9orf47(1), CNR1(1), CNR2(3), DNMT1(4), MTNR1A(2), MTNR1B(2), PTAFR(2), PTGER4(2), PTGFR(7), TBXA2R(1) 13305806 25 13 25 18 9 3 0 9 4 0 0.961 1.000 1.000 607 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(1), ACAA2(3), ACAT2(1), ECHS1(3), EHHADH(2), HADHA(3), SDS(1) 9915205 14 12 14 10 2 4 2 2 4 0 0.921 1.000 1.000 608 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 FUT2(2), GBGT1(2), GLA(2), HEXA(1), HEXB(1), ST3GAL1(3), ST3GAL2(1), ST3GAL4(3), ST8SIA1(2) 12005633 17 12 17 12 6 1 1 6 3 0 0.989 1.000 1.000 609 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 B3GALNT1(2), B3GALT5(2), FUT2(2), GBGT1(2), GLA(2), HEXA(1), HEXB(1), ST3GAL1(3), ST3GAL2(1), ST8SIA1(2) 12742387 18 12 18 14 5 1 1 8 3 0 0.996 1.000 1.000 610 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 CDC34(2), NRF1(2), UBE2E3(1), UBE2G2(1), UBE2L6(1), UBE2M(2), UBE3A(1) 12501412 10 10 10 11 5 1 2 0 2 0 0.989 1.000 1.000 611 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(3), ADH1B(4), ADH6(3), ADH7(2), ADHFE1(2) 6687477 14 9 14 8 2 1 1 10 0 0 0.911 1.000 1.000 612 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(3), EPHX2(2), HSD3B7(1) 5693548 6 6 6 5 3 0 0 3 0 0 0.958 1.000 1.000 613 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA3(2), LTB4R(1), P2RY1(1), P2RY2(3), P2RY6(2) 7080381 9 4 9 8 5 2 0 2 0 0 0.944 1.000 1.000 614 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 603256 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 615 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 1815426 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 616 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 2029362 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000