rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 64 ATM(16), CCNA1(7), CCNB1(3), CCND1(4), CCND2(2), CCNE1(5), CCNE2(4), CCNG2(4), CDC25A(2), CDK4(5), CDKN1B(2), CDKN2A(114), CDKN2C(1), CREB3L1(4), CREB3L3(9), CREB3L4(2), E2F2(3), E2F3(3), E2F4(2), E2F5(6), E2F6(1), GADD45A(1), GBA2(6), MCM2(4), MCM3(4), MCM4(7), MCM5(2), MCM6(4), MCM7(9), MDM2(2), MNAT1(1), MYC(6), MYT1(12), NACA(25), PCNA(1), POLA2(2), POLE(11), POLE2(1), PRIM1(3), RB1(18), RBL1(11), RPA1(5), RPA2(1), TFDP1(2), TFDP2(1), TNXB(23), TP53(426), WEE1(1) 58754687 788 415 508 77 104 113 138 112 307 14 <1.00e-15 <1.00e-15 <5.93e-14 2 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 41 APAF1(12), BAK1(1), BAX(1), BCL2(1), BCL2L1(2), BID(3), BIRC2(2), BIRC3(2), CASP2(3), CASP3(2), CASP6(5), CASP7(3), CASP8(61), CASP9(1), FADD(4), FAS(5), FASLG(1), GZMB(2), JUN(1), MAP2K4(2), MAP3K1(6), MAPK10(4), MCL1(3), MDM2(2), MYC(6), NFKB1(5), NFKBIA(1), PARP1(5), PRF1(4), RELA(2), RIPK1(2), TNFRSF1A(1), TNFRSF1B(2), TNFSF10(1), TP53(426), TRADD(1), TRAF2(2) 28538961 587 399 356 33 94 78 95 89 219 12 <1.00e-15 <1.00e-15 <5.93e-14 3 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 22 ATM(16), ATR(25), BRCA1(12), CCNB1(3), CDC25A(2), CDC25B(4), CDC25C(4), CDC34(4), CHEK1(1), CHEK2(5), EP300(39), GADD45A(1), MDM2(2), MYT1(12), PRKDC(28), RPS6KA1(10), TP53(426), WEE1(1), YWHAH(2), YWHAQ(3) 31890716 600 394 376 34 94 85 107 102 202 10 1.33e-15 <1.00e-15 <5.93e-14 4 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 18 DNAJA3(3), IFNG(2), IFNGR1(4), IFNGR2(5), IKBKB(12), JAK2(5), LIN7A(5), NFKB1(5), NFKBIA(1), RB1(18), RELA(2), TNFRSF1A(1), TNFRSF1B(2), TP53(426), USH1C(3), WT1(3) 13844325 497 384 279 27 78 57 84 75 193 10 <1.00e-15 <1.00e-15 <5.93e-14 5 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 16 APAF1(12), ATM(16), BAX(1), BCL2(1), CCND1(4), CCNE1(5), CDK4(5), GADD45A(1), MDM2(2), PCNA(1), RB1(18), TP53(426) 13779449 492 379 275 19 76 61 71 80 194 10 <1.00e-15 <1.00e-15 <5.93e-14 6 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 15 CCND1(4), CDK4(5), CDKN1B(2), CDKN2A(114), CFL1(2), E2F2(3), MDM2(2), PRB1(8), TP53(426) 6424705 566 372 289 17 77 55 77 79 265 13 <1.00e-15 <1.00e-15 <5.93e-14 7 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 9 CHUK(6), DNAJC3(2), EIF2S1(2), EIF2S2(6), NFKB1(5), NFKBIA(1), RELA(2), TP53(426) 7476252 450 367 233 14 76 50 66 70 178 10 <1.00e-15 <1.00e-15 <5.93e-14 8 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 AKT1(2), CCND1(4), CCNE1(5), CDK4(5), CDK6(2), CDKN1B(2), HRAS(32), MAPK1(9), NFKB1(5), NFKBIA(1), PAK1(3), PIK3CA(96), PIK3R1(10), RAC1(15), RAF1(3), RB1(18), RELA(2), TFDP1(2) 15389151 216 171 118 19 26 75 38 44 33 0 1.18e-13 <1.00e-15 <5.93e-14 9 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 CSNK2A1(7), ELK1(2), FOS(6), HRAS(32), INSR(3), IRS1(4), JUN(1), MAP2K1(5), MAPK8(4), PIK3CA(96), PIK3R1(10), PTPN11(2), RAF1(3), RASA1(17), SHC1(3), SLC2A4(3), SOS1(9), SRF(1) 19385060 208 169 122 10 18 69 47 45 28 1 <1.00e-15 <1.00e-15 <5.93e-14 10 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 AKT1(2), BAD(1), CASP9(1), CHUK(6), GH1(4), GHR(8), NFKB1(5), NFKBIA(1), PDPK1(4), PIK3CA(96), PIK3R1(10), RELA(2), YWHAH(2) 10744900 142 127 80 10 7 67 17 37 14 0 6.29e-11 1.11e-15 5.93e-14 11 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 16 ABL1(8), CDKN2A(114), MDM2(2), MYC(6), PIK3CA(96), PIK3R1(10), POLR1A(10), POLR1B(4), POLR1C(2), RAC1(15), RB1(18), TBX2(4), TP53(426), TWIST1(1) 15420104 716 420 368 21 90 117 89 118 289 13 <1.00e-15 1.22e-15 5.93e-14 12 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 15 AKT1(2), BCL2(1), EGFR(19), IGF1R(13), MYC(6), POLR2A(11), PRKCA(7), RB1(18), TEP1(16), TERF1(5), TERT(3), TNKS(7), TP53(426), XRCC5(4) 21499108 538 389 319 45 85 74 90 84 194 11 <1.00e-15 1.33e-15 5.93e-14 13 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 80 AIFM1(1), AKT1(2), AKT2(3), AKT3(6), APAF1(12), ATM(16), BAD(1), BAX(1), BCL2(1), BCL2L1(2), BID(3), BIRC2(2), BIRC3(2), CAPN1(3), CAPN2(6), CASP10(2), CASP3(2), CASP6(5), CASP7(3), CASP8(61), CASP9(1), CFLAR(2), CHUK(6), CSF2RB(8), FADD(4), FAS(5), FASLG(1), IKBKB(12), IL1A(1), IL1B(1), IL1R1(4), IL1RAP(6), IL3(1), IL3RA(6), IRAK1(3), IRAK2(2), IRAK3(9), IRAK4(3), NFKB1(5), NFKB2(5), NFKBIA(1), NTRK1(3), PIK3CA(96), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PPP3CA(2), PPP3CB(1), PRKACA(4), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), RELA(2), RIPK1(2), TNFRSF10A(3), TNFRSF10B(1), TNFRSF10D(1), TNFRSF1A(1), TNFSF10(1), TP53(426), TRADD(1), TRAF2(2) 63595168 848 437 555 89 124 168 137 153 254 12 <1.00e-15 1.44e-15 5.93e-14 14 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 13 CREBBP(39), DAXX(5), HRAS(32), PAX3(6), PML(1), RARA(4), RB1(18), SIRT1(2), SP100(8), TNFRSF1A(1), TNFRSF1B(2), TP53(426) 14483208 544 402 303 31 87 65 103 80 198 11 <1.00e-15 1.44e-15 5.93e-14 15 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 19 ABL1(8), ATM(16), BRCA1(12), CHEK1(1), CHEK2(5), GADD45A(1), JUN(1), MAPK8(4), MDM2(2), MRE11A(3), NFKB1(5), NFKBIA(1), RAD50(9), RAD51(1), RBBP8(7), RELA(2), TP53(426) 22691030 504 376 286 29 78 65 85 81 185 10 <1.00e-15 1.44e-15 5.93e-14 16 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 65 APAF1(12), ATM(16), ATR(25), BAI1(8), BAX(1), BID(3), CASP3(2), CASP8(61), CASP9(1), CCNB1(3), CCNB3(11), CCND1(4), CCND2(2), CCNE1(5), CCNE2(4), CCNG1(1), CCNG2(4), CDK4(5), CDK6(2), CDKN2A(114), CHEK1(1), CHEK2(5), DDB2(4), EI24(2), FAS(5), GADD45A(1), GADD45G(1), GTSE1(8), IGF1(1), IGFBP3(1), MDM2(2), MDM4(1), PERP(1), PMAIP1(2), PPM1D(6), PTEN(14), RCHY1(1), RFWD2(2), RRM2(1), RRM2B(1), SERPINE1(8), SESN1(2), SESN2(3), SESN3(3), SFN(7), SIAH1(3), STEAP3(4), THBS1(8), TNFRSF10B(1), TP53(426), TSC2(8), ZMAT3(2) 49796429 819 417 530 66 103 109 120 130 342 15 <1.00e-15 1.55e-15 5.98e-14 17 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 19 ABCB1(20), AKT1(2), ATM(16), BAX(1), CPB2(4), CSNK1A1(1), CSNK1D(1), FHL2(1), GADD45A(1), HIC1(1), HIF1A(3), IGFBP3(1), MAPK8(4), MDM2(2), NFKBIB(1), NQO1(3), TP53(426) 15825286 488 372 271 29 81 57 79 77 184 10 <1.00e-15 2.11e-15 7.20e-14 18 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 AKT1(2), CREB1(1), HRAS(32), MAPK1(9), MAPK7(6), MEF2A(3), MEF2B(5), MEF2C(15), MEF2D(1), NTRK1(3), PIK3CA(96), PIK3R1(10), PLCG1(8), RPS6KA1(10), SHC1(3) 14413023 204 163 113 12 27 72 42 46 17 0 <1.00e-15 2.11e-15 7.20e-14 19 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 59 ALG2(2), BAK1(1), BAX(1), BTK(8), CAD(5), CASP10(2), CASP3(2), CASP8(61), CD7(2), CSNK1A1(1), DAXX(5), DEDD(1), DEDD2(5), DIABLO(2), EGFR(19), EPHB2(3), FADD(4), FAF1(2), IL1A(1), MAP2K4(2), MAP2K7(2), MAP3K1(6), MAP3K5(6), MAPK1(9), MAPK10(4), MAPK8(4), MAPK8IP1(3), MAPK8IP2(3), MAPK8IP3(8), MAPK9(4), MET(4), NFAT5(13), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(1), NFKBIE(1), NFKBIL1(1), NR0B2(1), PFN1(1), PTPN13(13), RALBP1(5), RIPK1(2), ROCK1(19), TNFRSF6B(4), TP53(426), TPX2(5), TRAF2(2) 55474647 687 415 451 67 110 97 128 100 239 13 <1.00e-15 2.22e-15 7.20e-14 20 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 12 ATM(16), CDC25A(2), CDC25B(4), CDC25C(4), CDK4(5), CHEK1(1), MYT1(12), RB1(18), TP53(426), WEE1(1), YWHAH(2) 13349006 491 381 274 14 79 59 75 75 193 10 <1.00e-15 2.44e-15 7.41e-14 21 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 38 AKT1(2), ATF2(1), CDC42(3), DLD(1), DUSP10(3), DUSP4(1), DUSP8(1), GAB1(5), GADD45A(1), GCK(4), IL1R1(4), JUN(1), MAP2K4(2), MAP2K5(3), MAP2K7(2), MAP3K1(6), MAP3K10(6), MAP3K11(2), MAP3K12(8), MAP3K13(15), MAP3K2(1), MAP3K3(3), MAP3K4(14), MAP3K5(6), MAP3K7(8), MAP3K9(9), MAPK10(4), MAPK7(6), MAPK8(4), MAPK9(4), MYEF2(7), NFATC3(6), NR2C2(1), PAPPA(13), SHC1(3), TP53(426), TRAF6(3), ZAK(5) 38392565 594 387 374 49 98 83 118 92 193 10 <1.00e-15 2.66e-15 7.41e-14 22 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD28(3), CD3D(1), CD80(5), CD86(2), CTLA4(2), HLA-DRA(1), HLA-DRB1(2), ICOS(1), IL2(2), ITK(3), LCK(5), PIK3CA(96), PIK3R1(10), PTPN11(2) 9726595 135 123 73 8 2 63 14 39 17 0 2.43e-11 2.66e-15 7.41e-14 23 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 20 AKT1(2), APAF1(12), ATM(16), BAD(1), BAX(1), BCL2(1), BCL2L1(2), BID(3), CASP3(2), CASP6(5), CASP7(3), CASP9(1), EIF2S1(2), PRKCA(7), PTK2(8), PXN(2), STAT1(7), TLN1(24), TP53(426) 20835201 525 386 308 33 84 72 85 86 188 10 <1.00e-15 2.78e-15 7.41e-14 24 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 7 HDAC1(1), MAX(1), MYC(6), SP1(3), SP3(3), TP53(426), WT1(3) 5374456 443 361 224 12 72 49 69 70 173 10 <1.00e-15 2.89e-15 7.41e-14 25 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 21 ATM(16), ATR(25), BRCA1(12), BRCA2(16), CHEK1(1), CHEK2(5), FANCA(7), FANCC(3), FANCD2(9), FANCF(2), FANCG(2), HUS1(2), MRE11A(3), RAD17(7), RAD50(9), RAD51(1), RAD9A(2), TP53(426), TREX1(4) 33493143 552 387 335 32 80 84 92 94 192 10 <1.00e-15 3.11e-15 7.63e-14 26 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 13 AKT1(2), CAT(4), GH1(4), GHR(8), HRAS(32), IGF1(1), IGF1R(13), PIK3CA(96), PIK3R1(10), SHC1(3), SOD1(1), SOD2(1), SOD3(3) 10132708 178 146 94 12 19 69 38 42 10 0 6.64e-14 3.22e-15 7.63e-14 27 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 66 APAF1(12), BAD(1), BAK1(1), BAX(1), BCL2(1), BCL2L1(2), BCL2L11(1), BID(3), BIRC2(2), BIRC3(2), BIRC5(1), CASP1(2), CASP10(2), CASP2(3), CASP3(2), CASP4(2), CASP6(5), CASP7(3), CASP8(61), CASP9(1), CHUK(6), FADD(4), FAS(5), FASLG(1), GZMB(2), HELLS(6), IKBKB(12), IRF1(8), IRF2(8), IRF3(2), IRF4(5), IRF5(3), IRF6(6), IRF7(3), JUN(1), LTA(4), MAP2K4(2), MAP3K1(6), MAPK10(4), MDM2(2), MYC(6), NFKB1(5), NFKBIA(1), NFKBIB(1), NFKBIE(1), PLEKHG5(6), PRF1(4), RELA(2), RIPK1(2), TNFRSF10B(1), TNFRSF1A(1), TNFRSF1B(2), TNFRSF21(6), TNFRSF25(2), TNFSF10(1), TP53(426), TRADD(1), TRAF2(2), TRAF3(6) 43759524 674 411 442 60 111 102 111 97 241 12 <1.00e-15 3.44e-15 7.85e-14 28 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 7 ATM(16), ATR(25), CDC25C(4), CHEK1(1), CHEK2(5), TP53(426), YWHAH(2) 12164049 479 367 262 14 76 61 71 81 180 10 <1.00e-15 3.77e-15 8.02e-14 29 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 CSNK2A1(7), ELK1(2), FOS(6), HRAS(32), JUN(1), KLK2(2), MAP2K1(5), MAPK8(4), NGFR(1), PIK3CA(96), PIK3R1(10), PLCG1(8), RAF1(3), SHC1(3), SOS1(9) 14516249 189 154 105 11 20 67 46 39 17 0 8.33e-15 3.77e-15 8.02e-14 30 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CCNA1(7), CCNB1(3), CCND1(4), CCND2(2), CCNE1(5), CDC25A(2), CDK4(5), CDK6(2), CDKN1B(2), CDKN2A(114), CDKN2C(1), RB1(18), RBL1(11), TFDP1(2) 12176555 178 162 118 19 8 17 19 18 113 3 2.24e-07 4.11e-15 8.43e-14 31 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 25 ABL1(8), ATM(16), ATR(25), CCNA1(7), CCND1(4), CCNE1(5), CDC25A(2), CDK4(5), CDK6(2), CDKN1B(2), CDKN2A(114), DHFR(3), GSK3B(3), HDAC1(1), RB1(18), SKP2(4), TFDP1(2), TGFB1(1), TGFB2(3), TGFB3(1), TP53(426) 22944260 652 395 374 32 85 70 95 98 291 13 <1.00e-15 4.33e-15 8.60e-14 32 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 AKT1(2), HRAS(32), KLK2(2), NTRK1(3), PIK3CA(96), PIK3R1(10), PLCG1(8), PRKCA(7), SHC1(3), SOS1(9) 11846864 172 145 88 13 16 68 38 40 10 0 3.68e-12 4.66e-15 8.98e-14 33 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 CSNK2A1(7), ELK1(2), FOS(6), HRAS(32), IGF1(1), IGF1R(13), IRS1(4), JUN(1), MAP2K1(5), MAPK8(4), PIK3CA(96), PIK3R1(10), PTPN11(2), RAF1(3), RASA1(17), SHC1(3), SOS1(9), SRF(1) 18853105 216 173 130 12 22 71 49 46 27 1 <1.00e-15 5.44e-15 1.02e-13 34 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 AKT1(2), BAD(1), BCL2L1(2), CASP9(1), CDC42(3), CHUK(6), ELK1(2), H2AFX(1), HRAS(32), MAP2K1(5), NFKB1(5), PIK3CA(96), PIK3R1(10), RAC1(15), RAF1(3), RALBP1(5), RALGDS(6), RELA(2), RHOA(10) 14514046 207 160 113 14 25 72 49 42 19 0 3.00e-15 5.66e-15 1.03e-13 35 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 AKT1(2), BAD(1), HRAS(32), IGF1R(13), IRS1(4), MAP2K1(5), MAPK1(9), PIK3CA(96), PIK3R1(10), RAF1(3), SHC1(3), SOS1(9), YWHAH(2) 14435703 189 151 98 12 26 71 39 41 12 0 3.00e-15 6.00e-15 1.06e-13 36 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(7), CCNA2(4), CCND1(4), CCNE1(5), CCNE2(4), CDK4(5), CDKN1B(2), CDKN2A(114), E2F2(3), E2F4(2), PRB1(8) 6829711 158 148 98 15 5 15 19 19 97 3 1.68e-07 6.44e-15 1.09e-13 37 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 B2M(10), HLA-A(24), IL18(1), ITGB1(16), KLRC1(1), KLRC2(1), KLRC3(3), KLRC4(1), LAT(3), MAP2K1(5), PAK1(3), PIK3CA(96), PIK3R1(10), PTK2B(4), PTPN6(2), RAC1(15), SYK(8), VAV1(8) 14134507 211 167 138 17 23 69 26 48 45 0 6.05e-13 6.55e-15 1.09e-13 38 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 AKT1(2), PIK3CA(96), PIK3R1(10), PLCB1(21), PLCG1(8), PRKCA(7), VAV1(8) 9755826 152 135 90 14 9 64 28 38 13 0 8.80e-10 6.88e-15 1.12e-13 39 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 BCL2(1), CASP3(2), CASP8(61), CFL1(2), CFLAR(2) 2949686 68 62 56 6 6 13 8 8 31 2 6.60e-05 8.22e-15 1.30e-13 40 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT1(2), AKT2(3), AKT3(6), ELK1(2), HRAS(32), MAP2K1(5), MAP2K2(6), NGFR(1), NTRK1(3), PIK3CA(96), PIK3CD(8), SHC1(3), SOS1(9) 12300008 176 146 92 19 24 64 37 44 7 0 1.75e-10 1.01e-11 1.55e-10 41 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 AKT1(2), BCAR1(3), CDKN1B(2), ILK(4), ITGB1(16), MAPK1(9), PDK2(1), PDPK1(4), PIK3CA(96), PIK3R1(10), PTEN(14), PTK2(8), SHC1(3), SOS1(9) 14721142 181 149 111 17 19 69 23 40 30 0 1.74e-10 3.25e-11 4.88e-10 42 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ACTR2(1), ARPC1B(3), ARPC2(2), ARPC3(1), ARPC4(1), CDC42(3), PAK1(3), PDGFRA(14), PIK3CA(96), PIK3R1(10), RAC1(15), WASL(2) 10169498 151 130 83 17 12 67 21 39 12 0 2.92e-07 9.91e-10 1.45e-08 43 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 CSNK2A1(7), FOS(6), HRAS(32), JAK2(5), JUN(1), MAP2K1(5), MPL(4), PIK3CA(96), PIK3R1(10), PLCG1(8), PRKCA(7), RAF1(3), RASA1(17), SHC1(3), SOS1(9), STAT1(7), STAT3(6), STAT5A(3), STAT5B(5), THPO(1) 22794563 235 178 149 20 24 80 54 45 31 1 3.97e-14 1.77e-09 2.53e-08 44 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 ADCY1(21), AKT1(2), CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), CREB1(1), GNAS(12), HRAS(32), MAPK1(9), MAPK14(2), PIK3CA(96), PIK3R1(10), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PRKCA(7), RAC1(15), RPS6KA1(10), RPS6KA5(5), SOS1(9) 22165552 258 196 159 27 44 87 55 50 22 0 2.06e-13 2.94e-08 4.11e-07 45 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(12), ARHGAP5(10), ARHGDIB(1), CASP1(2), CASP10(2), CASP3(2), CASP8(61), CASP9(1), GZMB(2), JUN(1), PRF1(4) 9810864 98 84 86 8 10 16 12 19 39 2 1.77e-05 8.26e-08 1.13e-06 46 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 AKT1(2), ANXA1(2), CALM1(1), CALM2(2), CALM3(2), GNAS(12), GNB1(3), NFKB1(5), NOS3(4), NPPA(3), NR3C1(6), PIK3CA(96), PIK3R1(10), RELA(2), SYT1(8) 13656765 158 133 97 14 15 67 20 42 14 0 6.61e-10 9.48e-08 1.27e-06 47 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 ADAM17(5), DLL1(5), FURIN(1), NOTCH1(95) 7141554 106 98 103 14 17 18 16 10 44 1 6.03e-05 2.08e-07 2.73e-06 48 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 AKT1(2), AKT2(3), AKT3(6), BPNT1(2), ILK(4), MAPK1(9), PDK1(3), PIK3CA(96), PIK3CD(8), PTEN(14), PTK2B(4), RBL2(6), SHC1(3), SOS1(9) 15549505 169 142 101 18 22 66 22 43 16 0 5.02e-10 3.93e-07 5.05e-06 49 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 BCL2(1), CREBBP(39), EP300(39), FYN(5), IL7(1), IL7R(6), JAK1(11), JAK3(6), LCK(5), NMI(6), PIK3CA(96), PIK3R1(10), PTK2B(4), STAT5A(3), STAT5B(5) 21261803 237 188 168 29 17 87 37 58 37 1 9.83e-12 3.09e-06 3.88e-05 50 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(7), ELK1(2), FOS(6), HRAS(32), JAK1(11), JUN(1), MAP2K1(5), MAP2K4(2), MAP3K1(6), MAPK8(4), PDGFRA(14), PIK3CA(96), PIK3R1(10), PLCG1(8), PRKCA(7), RAF1(3), RASA1(17), SHC1(3), SOS1(9), SRF(1), STAT1(7), STAT3(6), STAT5A(3) 26535800 260 194 174 28 27 84 62 49 37 1 1.67e-12 3.19e-06 3.93e-05 51 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 AKT1(2), EIF2B5(4), EIF2S1(2), EIF2S2(6), EIF2S3(1), EIF4E(1), EIF4EBP1(1), GSK3B(3), IGF1(1), IGF1R(13), INPPL1(9), PDK2(1), PDPK1(4), PIK3CA(96), PIK3R1(10), PTEN(14), RPS6KB1(5) 15006074 173 139 111 19 12 74 21 39 27 0 1.79e-09 3.34e-06 4.04e-05 52 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 18 APAF1(12), BAK1(1), BAX(1), BCL2(1), BCL2L1(2), BID(3), BIK(1), BIRC2(2), BIRC3(2), CASP3(2), CASP6(5), CASP7(3), CASP8(61), CASP9(1), DIABLO(2) 10208169 99 83 87 9 10 20 13 14 40 2 1.78e-05 5.20e-05 0.000616 53 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(21), ARHGEF1(9), F2(3), F2R(4), F2RL3(3), GNA12(1), GNA13(2), GNAI1(2), GNB1(3), MAP3K7(8), PIK3CA(96), PIK3R1(10), PLCB1(21), PPP1R12B(4), PRKCA(7), PTK2B(4), ROCK1(19) 19689317 217 173 153 28 22 78 46 52 19 0 7.11e-10 9.29e-05 0.00108 54 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 AKT1(2), CREB1(1), MAP2K1(5), MAP2K2(6), MAP2K3(4), MAP2K6(1), MAP3K1(6), MAPK1(9), MAPK14(2), NFKB1(5), PIK3CA(96), PIK3R1(10), RB1(18), RELA(2), SP1(3) 14760197 170 149 102 23 19 63 23 35 30 0 1.79e-06 0.000175 0.00199 55 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 25 GH1(4), GHR(8), HRAS(32), INSR(3), IRS1(4), JAK2(5), MAP2K1(5), MAPK1(9), PIK3CA(96), PIK3R1(10), PLCG1(8), PRKCA(7), PTPN6(2), RAF1(3), RPS6KA1(10), SHC1(3), SLC2A4(3), SOCS1(1), SOS1(9), SRF(1), STAT5A(3), STAT5B(5) 25163672 231 178 140 23 31 84 56 44 16 0 3.53e-14 0.000464 0.00519 56 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 CREB1(1), FOS(6), JUN(1), KEAP1(24), MAPK1(9), MAPK14(2), MAPK8(4), NFE2L2(27), PRKCA(7) 6773267 81 72 64 11 16 16 26 14 9 0 0.000432 0.00143 0.0157 57 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 AKT1(2), BCL2(1), BCR(2), CRKL(3), FOS(6), HRAS(32), JAK2(5), JUN(1), MAP2K1(5), MAP2K4(2), MAP3K1(6), MAPK8(4), MYC(6), PIK3CA(96), PIK3R1(10), RAF1(3), SOS1(9), STAT1(7), STAT5A(3), STAT5B(5) 21419823 208 160 122 26 18 82 49 41 18 0 6.52e-10 0.00321 0.0347 58 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BAG4(6), BIRC3(2), CASP8(61), FADD(4), RIPK1(2), TNFRSF1A(1), TNFRSF1B(2), TRADD(1), TRAF2(2) 6409161 81 70 69 11 9 13 14 11 32 2 0.000431 0.00420 0.0446 59 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 33 A1BG(7), AKT1(2), AKT2(3), AKT3(6), BAD(1), BTK(8), CDKN2A(114), GSK3A(2), GSK3B(3), IARS(11), IGFBP1(3), INPP5D(9), PDK1(3), PIK3CA(96), PPP1R13B(2), PTEN(14), RPS6KA1(10), RPS6KA2(6), RPS6KA3(4), RPS6KB1(5), SFN(7), SHC1(3), SOS1(9), SOS2(11), TEC(2), YWHAB(2), YWHAE(2), YWHAG(1), YWHAH(2), YWHAQ(3), YWHAZ(2) 27402412 353 257 232 47 23 89 54 65 118 4 1.48e-11 0.00763 0.0797 60 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CCNE1(5), CDC34(4), CUL1(11), FBXW7(34), RB1(18), TFDP1(2) 6256728 74 66 65 11 7 14 16 8 28 1 0.0172 0.0100 0.103 61 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 AKT1(2), EIF4A1(3), EIF4A2(2), EIF4B(7), EIF4E(1), EIF4EBP1(1), EIF4G1(19), EIF4G2(9), EIF4G3(9), MKNK1(1), PDK2(1), PDPK1(4), PIK3CA(96), PIK3R1(10), PTEN(14), RPS6KB1(5), TSC1(4), TSC2(8) 21047491 196 158 134 23 9 78 31 42 36 0 9.97e-09 0.0289 0.292 62 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 AKT1(2), BAD(1), CHRNB1(1), CHRNG(9), MUSK(7), PIK3CA(96), PIK3R1(10), PTK2(8), PTK2B(4), TERT(3), YWHAH(2) 12473639 143 131 82 24 9 64 18 38 14 0 2.14e-06 0.0428 0.425 63 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 82 ABL1(8), ATM(16), BUB1(6), BUB1B(7), CCNA1(7), CCNA2(4), CCNB1(3), CCNB3(11), CCND2(2), CCNE1(5), CCNE2(4), CDAN1(7), CDC14A(3), CDC14B(1), CDC20(2), CDC25A(2), CDC25B(4), CDC25C(4), CDC6(2), CDC7(1), CDH1(5), CDK4(5), CDKN2A(114), CHEK1(1), CHEK2(5), DTX4(5), E2F2(3), E2F3(3), E2F4(2), E2F5(6), E2F6(1), EP300(39), ESPL1(10), GADD45A(1), GSK3B(3), HDAC1(1), HDAC2(3), HDAC3(3), HDAC4(10), HDAC5(3), HDAC6(8), HDAC8(1), MAD1L1(4), MAD2L1(1), MAD2L2(2), MCM2(4), MCM3(4), MCM4(7), MCM5(2), MCM6(4), MCM7(9), MDM2(2), MPEG1(7), MPL(4), PCNA(1), PLK1(3), PRKDC(28), PTPRA(4), RB1(18), RBL1(11), SKP2(4), SMAD4(14), TBC1D8(4), TFDP1(2), TGFB1(1), TP53(426), WEE1(1) 83552232 898 436 613 111 121 130 154 139 341 13 <1.00e-15 0.0534 0.522 64 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 35 ACTA1(4), CRK(2), CRKL(3), DOCK1(15), ELK1(2), FOS(6), GAB1(5), HGF(12), HRAS(32), ITGA1(4), ITGB1(16), JUN(1), MAP2K1(5), MAP2K2(6), MAP4K1(4), MAPK1(9), MAPK8(4), MET(4), PAK1(3), PIK3CA(96), PIK3R1(10), PTEN(14), PTK2(8), PTK2B(4), PTPN11(2), PXN(2), RAF1(3), RAP1B(3), RASA1(17), SOS1(9), STAT3(6) 33522430 311 222 215 36 41 81 74 68 46 1 2.15e-12 0.0698 0.672 65 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 22 AKT1(2), EIF4A1(3), EIF4A2(2), EIF4E(1), EIF4EBP1(1), EIF4G1(19), EIF4G2(9), EIF4G3(9), GHR(8), IRS1(4), MAPK1(9), MAPK14(2), MKNK1(1), PABPC1(1), PDK2(1), PDPK1(4), PIK3CA(96), PIK3R1(10), PRKCA(7), PTEN(14), RPS6KB1(5) 21442415 208 165 139 27 13 82 31 46 36 0 3.79e-08 0.0817 0.775 66 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(7), EGF(9), EGFR(19), ELK1(2), FOS(6), HRAS(32), JAK1(11), JUN(1), MAP2K1(5), MAP2K4(2), MAP3K1(6), MAPK8(4), PIK3CA(96), PIK3R1(10), PLCG1(8), PRKCA(7), RAF1(3), RASA1(17), SHC1(3), SOS1(9), SRF(1), STAT1(7), STAT3(6), STAT5A(3) 28485311 274 206 188 33 27 86 65 56 38 2 1.92e-11 0.0902 0.842 67 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(12), BIRC2(2), BIRC3(2), CASP10(2), CASP3(2), CASP7(3), CASP8(61), CASP9(1), GZMB(2), PRF1(4), SCAP(9), SREBF1(5), SREBF2(5) 13843945 110 91 98 12 14 19 18 17 40 2 1.83e-05 0.185 1.000 68 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 CMBL(2) 386575 2 2 2 0 0 0 0 0 2 0 0.660 0.290 1.000 69 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(2), FOS(6), HRAS(32), JUN(1), MAP2K1(5), MAPK1(9), MYC(6), NFKB1(5), NFKBIA(1), PLCB1(21), PRKCA(7), RAF1(3), RELA(2) 11837893 100 89 67 15 22 17 42 11 8 0 0.000172 0.297 1.000 70 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 BPNT1(2), PAPSS1(6), PAPSS2(6), SULT1A2(1), SULT1E1(5), SULT2A1(2), SUOX(2) 4644911 24 22 24 2 5 7 5 5 2 0 0.0310 0.455 1.000 71 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 CREB1(1), HRAS(32), PTK2B(4), SHC1(3), SOS1(9) 6702458 49 44 26 7 14 5 22 6 2 0 0.0219 0.501 1.000 72 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 ARNT(8), EIF1(2), EIF2B1(1), EIF2B2(3), EIF2B3(4), EIF2B4(4), EIF2B5(4), EIF2S1(2), EIF2S2(6), EIF2S3(1), ELAVL1(5), FLT1(17), FLT4(13), HIF1A(3), HRAS(32), KDR(13), NOS3(4), PIK3CA(96), PIK3R1(10), PLCG1(8), PRKCA(7), PTK2(8), PXN(2), SHC1(3) 25828702 256 188 172 32 35 88 57 52 24 0 7.30e-11 0.529 1.000 73 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(2) 549130 2 2 2 1 1 0 0 1 0 0 0.796 0.558 1.000 74 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 CEBPB(1), CSNK2A1(7), ELK1(2), FOS(6), HRAS(32), IL6(2), IL6R(5), IL6ST(4), JAK1(11), JAK2(5), JAK3(6), JUN(1), MAP2K1(5), PTPN11(2), RAF1(3), SHC1(3), SOS1(9), SRF(1), STAT3(6) 18102118 111 97 88 12 20 15 44 19 13 0 1.75e-05 0.566 1.000 75 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(3), PGLYRP2(6) 1383171 9 9 9 2 1 3 2 2 1 0 0.347 0.598 1.000 76 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 32 DUSP1(2), MAP2K4(2), MAP2K7(2), MAPK1(9), MAPK10(4), MAPK11(3), MAPK12(3), MAPK13(3), MAPK14(2), MAPK8(4), MAPK8IP1(3), MAPK8IP2(3), MAPK8IP3(8), MAPK9(4), MAPKAPK5(2), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(1), NFKBIE(1), NFKBIL1(1), PIK3CA(96), PIK3CD(8), PIK3R1(10), SYT1(8), TRAF2(2), TRAF3(6), TRAF5(1), TRAF6(3) 25656897 202 161 134 29 29 73 32 41 27 0 1.05e-09 0.625 1.000 77 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(4), RAB11A(1), RAB1A(2), RAB27A(1), RAB3A(2), RAB4A(1), RAB5A(3) 3208378 14 14 14 1 5 4 2 2 1 0 0.0336 0.654 1.000 78 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(6), CYP2C9(7) 1537915 13 13 13 3 0 4 5 3 1 0 0.369 0.655 1.000 79 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALT(2), TGDS(3), UGDH(4), UXS1(2) 2921501 11 11 11 0 0 1 5 4 1 0 0.104 0.662 1.000 80 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(2), TPI1(4) 1256585 6 6 6 2 1 3 2 0 0 0 0.649 0.695 1.000 81 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 34 AKT1(2), BAD(1), BCL2(1), BCL2L1(2), CBL(3), CFLAR(2), CRKL(3), FOS(6), HRAS(32), IL2RA(2), IL2RB(3), IRS1(4), JAK1(11), JAK3(6), MAPK1(9), MYC(6), NMI(6), PIK3CA(96), PIK3R1(10), PTPN6(2), RAF1(3), RPS6KB1(5), SHC1(3), SOCS1(1), SOCS3(1), SOS1(9), STAT5A(3), STAT5B(5), SYK(8) 27493128 245 181 152 30 30 90 52 49 24 0 7.65e-13 0.715 1.000 82 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(2), CDO1(2), CSAD(5), GAD1(4), GAD2(7), GGT1(4) 4376205 24 24 24 4 4 7 6 2 5 0 0.0654 0.725 1.000 83 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 ADCY1(21), AKT1(2), BAD(1), BAX(1), BCL2(1), BCL2L1(2), CSF2RB(8), IGF1(1), IGF1R(13), IL3(1), IL3RA(6), KIT(11), KITLG(1), PIK3CA(96), PIK3R1(10), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), YWHAH(2) 16694904 193 153 131 31 17 79 30 47 20 0 5.93e-08 0.737 1.000 84 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 ADAM17(5), APC(27), AXIN1(11), BTRC(1), CTNNB1(6), DLL1(5), DVL1(7), FZD1(6), GSK3B(3), NOTCH1(95), WNT1(2) 16419280 168 130 164 28 27 33 30 22 54 2 0.000149 0.749 1.000 85 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 BCAR1(3), CRK(2), CXCL12(3), CXCR4(2), GNAI1(2), GNB1(3), HRAS(32), MAP2K1(5), MAPK1(9), NFKB1(5), PIK3C2G(13), PIK3CA(96), PIK3R1(10), PLCG1(8), PRKCA(7), PTK2(8), PTK2B(4), PXN(2), RAF1(3), RELA(2) 21054454 219 168 127 31 30 71 48 47 23 0 2.65e-08 0.753 1.000 86 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 CDK5(3), CDK5R1(1), EGR1(4), HRAS(32), KLK2(2), MAP2K1(5), MAP2K2(6), MAPK1(9), NGFR(1), RAF1(3) 6215510 66 58 36 13 22 8 25 5 6 0 0.00510 0.755 1.000 87 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALT(2), TGDS(3), UGDH(4), UGP2(2), UXS1(2) 3720453 13 13 13 0 0 1 7 4 1 0 0.0736 0.763 1.000 88 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(12), ARHGDIB(1), BIRC2(2), BIRC3(2), CASP1(2), CASP10(2), CASP2(3), CASP3(2), CASP4(2), CASP6(5), CASP7(3), CASP8(61), CASP9(1), GZMB(2), LMNA(1), LMNB1(1), LMNB2(8), PRF1(4) 14688009 114 91 102 14 14 21 17 20 40 2 8.61e-05 0.764 1.000 89 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYC(2), RB1(18), SP1(3), SP3(3) 5049097 26 26 26 9 0 2 5 4 15 0 0.839 0.784 1.000 90 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 ADCY1(21), AKT1(2), ASAH1(1), GNAI1(2), GNB1(3), ITGAV(6), ITGB3(6), MAPK1(9), PDGFRA(14), PIK3CA(96), PIK3R1(10), PLCB1(21), PRKCA(7), PTK2(8), RAC1(15) 20861205 221 178 144 33 28 81 42 49 21 0 5.38e-09 0.791 1.000 91 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD28(3), CD4(1), HLA-DRA(1), HLA-DRB1(2) 1800404 7 7 6 2 0 1 0 3 3 0 0.747 0.792 1.000 92 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 LPL(4), NR3C1(6), PPARG(1), RXRA(5) 4399391 16 16 16 1 2 4 6 2 2 0 0.0307 0.809 1.000 93 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(1), ALDH1A2(10), RDH5(1) 2966657 12 12 12 2 1 1 5 2 3 0 0.404 0.826 1.000 94 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(2), GSTZ1(1), HGD(4) 1694316 7 7 7 2 1 3 2 0 1 0 0.481 0.830 1.000 95 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(39), EP300(39), ESR1(6), MAPK1(9), PELP1(2) 11210168 95 86 80 15 17 18 21 16 22 1 0.00111 0.839 1.000 96 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(2), CDC25B(4), CHEK1(1), NEK1(9), WEE1(1) 5221484 17 17 17 1 4 3 6 1 3 0 0.124 0.841 1.000 97 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(16), C5(11), C6(25), C7(12), C8A(8), C9(15) 9561208 87 71 86 14 11 24 26 13 13 0 0.00556 0.846 1.000 98 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 CDK5(3), FOSB(1), GRIA2(16), JUND(1), PPP1R1B(2) 2839623 23 22 23 6 4 6 11 2 0 0 0.219 0.874 1.000 99 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(27), CDH1(5), CREBBP(39), EP300(39), MAP2K1(5), MAP3K7(8), SKIL(3), TGFB1(1), TGFB2(3), TGFB3(1), TGFBR1(2), TGFBR2(25) 19514612 158 124 139 23 20 32 35 32 38 1 0.000286 0.891 1.000 100 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(7), ELK1(2), EPO(2), EPOR(2), FOS(6), HRAS(32), JAK2(5), JUN(1), MAP2K1(5), MAPK8(4), PLCG1(8), PTPN6(2), RAF1(3), SHC1(3), SOS1(9), STAT5A(3), STAT5B(5) 16317743 99 86 76 12 20 20 42 7 10 0 5.18e-05 0.898 1.000 101 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(10), PARK2(4), SNCA(1), SNCAIP(3), UBE2L3(2), UBE2L6(2) 4889898 22 20 22 4 4 5 4 7 2 0 0.155 0.926 1.000 102 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCR3(6), HLA-DRA(1), HLA-DRB1(2), IL3(1), IL5(2) 2305423 12 12 11 4 0 4 4 0 4 0 0.598 0.946 1.000 103 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIPT1(1) 1160551 1 1 1 0 0 0 0 1 0 0 0.757 0.951 1.000 104 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(2), IFNG(2), IL12A(1), IL12B(4), IL18(1), IL2(2) 2267286 12 12 12 4 1 2 2 4 3 0 0.769 0.956 1.000 105 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(3), PLCD1(4), PRKCA(7), TGM2(4) 3760452 18 18 18 4 2 6 5 3 2 0 0.114 0.957 1.000 106 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 B3GNT1(3), FUT2(2), FUT9(11), GCNT2(5), ST8SIA1(3) 4694960 24 23 23 5 3 6 13 2 0 0 0.154 0.957 1.000 107 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(39), EP300(39), LPL(4), NCOA1(7), NCOA2(8), PPARG(1), RXRA(5) 14060638 103 87 95 15 12 23 26 21 20 1 0.000982 0.958 1.000 108 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 42 CALM1(1), CALM2(2), CALM3(2), CD3D(1), ELK1(2), FOS(6), FYN(5), HRAS(32), JUN(1), LAT(3), LCK(5), MAP2K1(5), MAP2K4(2), MAP3K1(6), MAPK8(4), NFATC1(9), NFATC2(15), NFATC3(6), NFATC4(3), NFKB1(5), NFKBIA(1), PIK3CA(96), PIK3R1(10), PLCG1(8), PPP3CA(2), PPP3CB(1), PRKCA(7), PTPN7(4), RAC1(15), RAF1(3), RASA1(17), RELA(2), SHC1(3), SOS1(9), SYT1(8), VAV1(8), ZAP70(2) 36398434 311 218 218 41 46 88 73 60 43 1 1.24e-11 0.962 1.000 109 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 AOC2(5), AOC3(5), CES1(7), ESD(3) 4600242 20 19 20 3 2 9 7 0 2 0 0.0470 0.965 1.000 110 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3D(1) 860420 1 1 1 1 0 0 1 0 0 0 0.944 0.972 1.000 111 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 BTK(8), CALM1(1), CALM2(2), CALM3(2), ELK1(2), FCER1A(4), FOS(6), HRAS(32), JUN(1), LYN(8), MAP2K1(5), MAP2K4(2), MAP2K7(2), MAP3K1(6), MAPK1(9), MAPK8(4), NFATC1(9), NFATC2(15), NFATC3(6), NFATC4(3), PAK2(8), PIK3CA(96), PIK3R1(10), PLA2G4A(3), PLCG1(8), PPP3CA(2), PPP3CB(1), RAF1(3), SHC1(3), SOS1(9), SYK(8), SYT1(8), VAV1(8) 32740288 294 210 203 41 45 84 70 62 32 1 7.36e-10 0.975 1.000 112 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 FABP6(3), LDLR(5), NR0B2(1), NR1H3(1), NR1H4(6), RXRA(5) 4142702 21 20 20 4 4 6 6 1 4 0 0.117 0.981 1.000 113 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 FUT2(2), FUT3(3), FUT5(4), FUT6(2), ST3GAL3(4) 3898124 15 14 15 3 3 3 6 2 1 0 0.191 0.983 1.000 114 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(3), F2R(4), F2RL3(3), GNAI1(2), GNB1(3), HRAS(32), ITGA1(4), ITGB1(16), MAP2K1(5), MAPK1(9), PLA2G4A(3), PLCB1(21), PRKCA(7), PTGS1(7), PTK2(8), RAF1(3), SYK(8), TBXAS1(5) 18535678 143 115 111 23 29 21 50 22 21 0 0.000230 0.986 1.000 115 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 BPNT1(2), CHST11(4), CHST12(5), CHST13(5), PAPSS1(6), PAPSS2(6), SULT1A1(2), SULT1A2(1), SULT1E1(5), SULT2A1(2), SUOX(2) 7044363 40 37 40 7 10 7 11 8 4 0 0.0562 0.989 1.000 116 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 AKR1A1(1), ECHS1(2), EHHADH(5), HADHA(3), SDS(1) 3683426 12 10 12 2 0 4 3 3 2 0 0.269 0.989 1.000 117 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(4) 1300338 4 4 4 3 0 1 2 0 1 0 0.872 0.989 1.000 118 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(4), PSMA2(1), PSMA3(2), PSMA5(1), PSMA6(2), PSMB1(1), PSMB10(3), PSMB2(1), PSMB3(1), PSMB4(2), PSMB5(3), PSMB6(1), PSMB7(1), PSMB8(1), PSMB9(1) 6634572 25 23 25 4 1 5 8 7 4 0 0.159 0.991 1.000 119 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(4), ACADM(3), ACADS(2), ECHS1(2), HADHA(3) 4111521 14 14 14 3 2 3 4 4 1 0 0.357 0.992 1.000 120 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(10), DIAPH1(7), FYN(5), GSN(5), HRAS(32), ITGA1(4), ITGB1(16), MAP2K1(5), MAPK1(9), MYLK(8), PFN1(1), PIK3CA(96), PIK3R1(10), PTK2(8), PXN(2), RAF1(3), ROCK1(19), SHC1(3), TLN1(24) 28396862 267 192 175 38 37 80 59 61 30 0 1.21e-08 0.992 1.000 121 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(5), CYP2E1(6), NR1I3(1), PTGS1(7), PTGS2(4) 4058542 23 21 23 6 2 1 11 1 8 0 0.437 0.992 1.000 122 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT2(2), HMGCL(1), OXCT1(2) 2569006 5 5 5 2 1 0 1 1 2 0 0.781 0.993 1.000 123 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(3), B4GALT1(1), B4GALT2(5), B4GALT3(1), B4GALT5(3), FUT8(2), ST3GAL1(2), ST3GAL2(1), ST3GAL3(4), ST3GAL4(1) 6032901 23 21 23 4 6 3 7 2 5 0 0.180 0.994 1.000 124 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(6), FOSL1(3), FOSL2(10), IFNAR1(3), IFNAR2(2), MAPK8(4), NFKB1(5), RELA(2), TNFRSF11A(3), TNFSF11(1), TRAF6(3) 8440356 42 39 42 8 6 9 10 8 9 0 0.204 0.994 1.000 125 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(1), GOT2(3), TAT(1) 1997140 5 5 5 2 0 0 3 1 1 0 0.768 0.995 1.000 126 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(3), AASDHPPT(3), AASS(3), KARS(3) 3583040 12 12 12 3 1 1 2 3 5 0 0.515 0.996 1.000 127 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(2), ADH1B(2), ADH4(3), ADH6(1), ADH7(2), ADHFE1(4) 4282569 14 13 14 4 1 4 2 2 5 0 0.561 0.996 1.000 128 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(2), HLCS(1), SPCS1(2), SPCS3(1) 2321334 6 6 6 4 0 2 1 0 3 0 0.848 0.998 1.000 129 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCR3(6), CD4(1), HLA-DRA(1), HLA-DRB1(2), IL1B(1), IL4(1), IL5(2), IL5RA(3), IL6(2) 4052954 19 19 18 5 1 5 8 2 3 0 0.407 0.998 1.000 130 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(21), GNAS(12), GNB1(3), PRKACA(4), PRKAR1A(3) 5046187 43 36 42 9 15 6 13 6 3 0 0.0882 0.998 1.000 131 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(7), CCNE1(5), CDC34(4), CUL1(11), RB1(18), SKP2(4), TFDP1(2) 6468191 51 45 51 12 4 12 12 5 18 0 0.160 0.998 1.000 132 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(1), F13B(13), HSD17B1(2), HSD17B2(2), HSD17B3(2), HSD17B4(5), HSD17B7(1), HSD3B1(4), HSD3B2(4) 6158075 34 32 34 9 5 7 12 6 4 0 0.286 0.999 1.000 133 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1QA(3), C1R(4), C1S(6), C2(6), C3(16), C5(11), C6(25), C7(12), C8A(8), C9(15) 13331121 106 85 105 20 13 33 31 15 14 0 0.00398 0.999 1.000 134 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 BGN(1), DCN(4), FMOD(7), KERA(4), LUM(2) 2757273 18 14 18 6 1 8 5 2 2 0 0.389 0.999 1.000 135 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD28(3), CD4(1), CD80(5), HLA-DRA(1), HLA-DRB1(2), IL2(2), IL4(1) 3017930 15 15 14 5 0 4 4 4 3 0 0.664 0.999 1.000 136 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ3(2), COQ5(7), COQ6(2), COQ7(2), NDUFA12(1), NDUFA13(3) 3047233 17 16 17 5 2 3 7 2 3 0 0.532 0.999 1.000 137 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 49 AKT1(2), AKT2(3), AKT3(6), BRD4(9), CAP1(3), CBL(3), CDC42(3), CDKN2A(114), F2RL2(2), FLOT1(2), FLOT2(4), GSK3A(2), GSK3B(3), IGFBP1(3), INPPL1(9), IRS1(4), IRS2(6), IRS4(16), LNPEP(5), MAPK1(9), PARD3(15), PARD6A(1), PDK1(3), PIK3CA(96), PIK3CD(8), PIK3R1(10), PTEN(14), PTPN1(3), RAF1(3), RPS6KA1(10), RPS6KA2(6), RPS6KA3(4), RPS6KB1(5), SERPINB6(4), SFN(7), SHC1(3), SLC2A4(3), SORBS1(7), SOS1(9), SOS2(11), YWHAB(2), YWHAE(2), YWHAG(1), YWHAH(2), YWHAQ(3), YWHAZ(2) 45306745 442 286 313 63 50 109 70 75 135 3 5.66e-14 0.999 1.000 138 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDFT1(4), FDPS(2), GGPS1(1), IDI1(1), IDI2(1) 3251066 9 9 9 3 2 5 1 1 0 0 0.406 0.999 1.000 139 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT2(2), ACYP1(1), ECHS1(2), EHHADH(5), GCDH(2), HADHA(3), SDHB(1), SDS(1) 5938441 17 16 17 3 2 4 5 4 2 0 0.219 0.999 1.000 140 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAD(1), BAX(1), BCL2(1), CASP8(61), FADD(4), MAP2K1(5), MAP2K4(2), MAP3K1(6), MAPK1(9), MAPK8(4), NFKB1(5), NSMAF(6), RAF1(3), RELA(2), RIPK1(2), TNFRSF1A(1), TRADD(1), TRAF2(2) 15649806 116 97 97 22 22 14 25 14 39 2 0.00651 0.999 1.000 141 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 SNAP25(3), STX1A(5) 2472973 8 8 8 3 4 0 3 1 0 0 0.726 0.999 1.000 142 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(8), FOS(6), HRAS(32), IL3(1), IL3RA(6), JAK2(5), MAP2K1(5), PTPN6(2), RAF1(3), SHC1(3), SOS1(9), STAT5A(3), STAT5B(5) 13449770 88 75 65 15 16 19 35 11 7 0 0.00223 1.000 1.000 143 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(1), CD34(6), CD3D(1), CD4(1), CD58(2), CD8A(2), IL3(1), IL6(2), KITLG(1) 4699278 17 16 17 5 2 2 3 4 6 0 0.578 1.000 1.000 144 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(1), GLS2(2), GLUD1(4), GLUD2(10) 3468502 17 17 17 6 4 2 4 3 4 0 0.686 1.000 1.000 145 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDHB(4), BCKDK(6), CTH(3), MUT(5) 3728828 18 17 18 5 2 6 4 3 3 0 0.473 1.000 1.000 146 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(7), GOT1(1), GOT2(3), TAT(1), TYR(8) 3576674 20 18 20 6 2 3 10 1 4 0 0.520 1.000 1.000 147 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDFT1(4), FDPS(2), IDI1(1) 2430488 7 7 7 3 2 4 1 0 0 0 0.550 1.000 1.000 148 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNG(2), IFNGR1(4), IFNGR2(5), JAK1(11), JAK2(5), STAT1(7) 6222329 34 30 33 9 2 9 9 5 9 0 0.242 1.000 1.000 149 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(1), GPD2(5), NDUFA1(1), SDHA(7), SDHB(1), SDHC(1), UQCRC1(1) 5030336 17 17 16 4 1 5 6 4 1 0 0.336 1.000 1.000 150 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(3), SEC61A2(4), SRP54(2), SRP68(4), SRP72(1), SRPR(2) 5730942 16 15 16 3 2 8 5 1 0 0 0.202 1.000 1.000 151 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CD28(3), CD3D(1), CD4(1) 2438429 5 5 5 3 0 0 1 3 1 0 0.904 1.000 1.000 152 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 GNB1(3), HTR2C(3), PLCB1(21), TUB(3) 5432569 30 30 29 8 7 5 12 5 1 0 0.293 1.000 1.000 153 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA2(1), ACAT2(2), ECHS1(2), EHHADH(5), HADHA(3), HADHB(4), SDS(1) 6350763 18 16 18 4 1 3 8 4 2 0 0.416 1.000 1.000 154 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(7), ELK1(2), FOS(6), HRAS(32), IL2(2), IL2RA(2), IL2RB(3), JAK1(11), JAK3(6), JUN(1), LCK(5), MAP2K1(5), MAPK8(4), RAF1(3), SHC1(3), SOS1(9), STAT5A(3), STAT5B(5), SYK(8) 17713789 117 98 94 21 18 21 46 14 18 0 0.000914 1.000 1.000 155 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(3), EGF(9), EGFR(19), HRAS(32), MAP2K1(5), MAPK1(9), PTPRB(22), RAF1(3), RASA1(17), SHC1(3), SOS1(9), SPRY1(3), SPRY2(2), SPRY3(3), SPRY4(2) 18973452 141 125 109 26 28 17 49 23 22 2 0.00560 1.000 1.000 156 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CCNE1(5), CDKN1B(2), CKS1B(3), CUL1(11), NEDD8(2), RB1(18), RBX1(3), SKP2(4), TFDP1(2), UBE2M(2) 6508770 52 48 52 13 3 13 10 6 20 0 0.182 1.000 1.000 157 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(2), CAMK1G(2), HDAC9(16), MEF2A(3), MEF2B(5), MEF2C(15), MEF2D(1), MYOD1(2), YWHAH(2) 5857390 48 42 48 12 7 9 14 11 7 0 0.191 1.000 1.000 158 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CASP3(2), CD36(2), FOS(6), FYN(5), JUN(1), MAPK14(2), THBS1(8) 5637356 26 24 26 7 3 7 5 7 4 0 0.239 1.000 1.000 159 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(3), AASDH(5), AASDHPPT(3), AASS(3), KARS(3) 5282395 17 17 17 5 1 1 3 6 6 0 0.603 1.000 1.000 160 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 ANP32A(1), APEX1(1), CREBBP(39), GZMA(2), GZMB(2), HMGB2(2), PRF1(4), SET(1) 8072642 52 44 51 12 10 8 13 10 10 1 0.114 1.000 1.000 161 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1QA(3), C1R(4), C1S(6), C2(6), C3(16), C5(11), C6(25), C7(12), C8A(8), C9(15), MASP1(7), MASP2(5), MBL2(2) 16224110 120 92 118 23 15 35 32 21 17 0 0.00274 1.000 1.000 162 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(4), ADCY1(21), CAP1(3), CCNB1(3), CDC25C(4), GNAI1(2), GNAS(12), GNB1(3), HRAS(32), MAPK1(9), MYT1(12), PIN1(1), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), RPS6KA1(10) 15647677 132 106 101 22 41 22 42 15 12 0 0.000122 1.000 1.000 163 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(4), HK1(4), HK2(5), HK3(8), IMPA1(2), PGM1(5), PGM3(1), TGDS(3) 7766709 32 31 32 7 7 9 8 3 5 0 0.0943 1.000 1.000 164 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(6), AGT(4), AGTR2(2), EDN1(1), EDNRA(2), EDNRB(7), EGF(9), EGFR(19), FOS(6), HRAS(32), JUN(1), MYC(6), NFKB1(5), PLCG1(8), PRKCA(7), RELA(2) 15638469 117 102 92 26 19 24 49 16 8 1 0.0158 1.000 1.000 165 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA1(1), NDUFA5(3), NDUFB2(2), NDUFB4(1), NDUFB6(1), NDUFS1(1), NDUFS2(3), NDUFV1(3) 5283313 15 14 15 3 3 5 5 1 1 0 0.283 1.000 1.000 166 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(5), CREB1(1), CREBBP(39), EP300(39), NCOA3(8), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), RARA(4), RXRA(5) 15705952 117 99 109 23 20 29 23 19 25 1 0.00525 1.000 1.000 167 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(1), ECHS1(2), HADH(4), HADHA(3), HADHB(4), HSD17B10(1), HSD17B4(5), MECR(3), PPT1(1), PPT2(2) 6441487 26 23 26 6 2 3 10 7 4 0 0.309 1.000 1.000 168 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(16), CDC25A(2), CDC25B(4), CDC25C(4), CHEK1(1), MYT1(12), WEE1(1), YWHAH(2) 10453443 42 37 42 7 7 9 11 8 7 0 0.120 1.000 1.000 169 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(8), GAD1(4), HDC(4), PNMT(1), TH(3), TPH1(2) 4604224 22 22 22 8 3 2 11 1 5 0 0.649 1.000 1.000 170 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CHUK(6), CREBBP(39), EP300(39), FADD(4), HDAC3(3), IKBKB(12), NFKB1(5), NFKBIA(1), RELA(2), RIPK1(2), TNFRSF1A(1), TNFRSF1B(2), TRADD(1), TRAF6(3) 17062244 120 108 112 23 17 25 31 22 24 1 0.00407 1.000 1.000 171 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 CCL2(2), CSF1(2), IL6(2), LDLR(5), LPL(4) 4042609 15 15 14 5 2 5 6 1 1 0 0.487 1.000 1.000 172 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(5), CHPT1(2), HEMK1(1), LCMT1(2), LCMT2(7), METTL2B(4), METTL6(3), PCYT1A(2), PCYT1B(2), PRMT2(1), PRMT3(6), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(4) 10663831 47 41 47 9 11 11 12 6 7 0 0.0430 1.000 1.000 173 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNB1(3), CDC25A(2), CDC25B(4), CDC25C(4), MNAT1(1), SHH(2), XPO1(6) 6560593 22 22 22 5 6 5 3 5 3 0 0.322 1.000 1.000 174 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 ATF2(1), BCR(2), BLNK(5), ELK1(2), FOS(6), HRAS(32), JUN(1), LYN(8), MAP2K1(5), MAP3K1(6), MAPK1(9), MAPK8IP3(8), PAPPA(13), RAC1(15), RPS6KA1(10), RPS6KA3(4), SHC1(3), SOS1(9), SYK(8), VAV1(8), VAV2(4), VAV3(4) 24385135 163 127 126 27 45 22 50 21 25 0 0.000114 1.000 1.000 175 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ARG1(1), GLS(1), GLUD1(4), OAT(1), PRODH(1) 4210897 8 8 8 3 0 2 1 3 2 0 0.659 1.000 1.000 176 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(5), B4GALT7(2), HS3ST2(2), HS3ST3A1(3), HS3ST3B1(1), XYLT1(10), XYLT2(3) 5041172 26 25 26 8 4 3 7 7 5 0 0.440 1.000 1.000 177 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(5), B4GALT7(2), HS3ST2(2), HS3ST3A1(3), HS3ST3B1(1), XYLT1(10), XYLT2(3) 5041172 26 25 26 8 4 3 7 7 5 0 0.440 1.000 1.000 178 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(4), ST3GAL1(2), ST3GAL2(1), ST3GAL4(1), ST3GAL5(6), ST6GALNAC2(3), ST8SIA1(3) 4298913 20 19 20 7 4 4 6 2 4 0 0.426 1.000 1.000 179 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(8), ASPH(10), COPS5(2), CREB1(1), EDN1(1), EP300(39), EPO(2), HIF1A(3), JUN(1), LDHA(1), NOS3(4), P4HB(1) 12917805 73 71 66 14 11 20 14 15 13 0 0.0179 1.000 1.000 180 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(12), BAD(1), BAK1(1), BAX(1), BCL10(1), BCL2(1), BCL2L1(2), BCL2L11(1), BID(3), CASP9(1), CES1(7) 8316255 31 30 31 7 6 8 5 5 7 0 0.305 1.000 1.000 181 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(10), PDXK(1), PSAT1(1) 3686452 12 10 12 6 1 2 1 6 2 0 0.874 1.000 1.000 182 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(7), ACO2(3), FH(3), IDH1(4), IDH2(1), MDH1(1), MDH2(1), SDHB(1), SUCLA2(1) 6763942 22 19 22 5 2 8 9 1 2 0 0.223 1.000 1.000 183 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(10), CD3D(1), GZMB(2), HLA-A(24), ICAM1(6), ITGAL(7), ITGB2(4), PRF1(4) 6654400 58 49 54 16 6 7 8 8 29 0 0.234 1.000 1.000 184 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 AKT1(2), APC(27), AXIN1(11), CCND1(4), CD14(1), CTNNB1(6), DVL1(7), FZD1(6), GJA1(2), GNAI1(2), GSK3B(3), IRAK1(3), LBP(8), LEF1(5), LY96(2), NFKB1(5), PDPK1(4), PIK3CA(96), PIK3R1(10), RELA(2), TIRAP(1), TLR4(16), TOLLIP(2), WNT1(2) 23476723 227 168 164 40 20 89 38 49 30 1 6.97e-07 1.000 1.000 185 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ADAM17(5), ERBB4(21), NRG2(5), NRG3(17), PRKCA(7) 6834830 55 50 55 15 4 9 20 12 10 0 0.406 1.000 1.000 186 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 ATP6V0C(1), GGT1(4), SHMT1(1), SHMT2(2) 3159906 8 8 8 5 3 0 3 1 1 0 0.886 1.000 1.000 187 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(1), DAG1(5), ITPKB(5) 4610024 11 9 11 4 1 3 4 1 2 0 0.609 1.000 1.000 188 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1QA(3), C1R(4), C1S(6), C2(6), C3(16), C5(11), C6(25), C7(12), C8A(8), C8B(9), C9(15), MASP1(7) 15837913 122 94 120 26 15 34 36 20 17 0 0.0106 1.000 1.000 189 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(4), CTH(3), GOT1(1), GOT2(3), LDHA(1), LDHB(1), LDHC(4), MPST(2) 5208192 19 17 19 6 4 1 11 2 1 0 0.604 1.000 1.000 190 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD4(1), CD8A(2), CSF1(2), EPO(2), IL2(2), IL3(1), IL4(1), IL5(2), IL6(2), IL7(1), IL9(2) 4619492 18 18 18 9 4 3 6 3 2 0 0.833 1.000 1.000 191 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(21), CREM(1), FHL5(5), FSHB(2), FSHR(12), GNAS(12), XPO1(6) 7305896 59 50 58 13 14 11 18 13 3 0 0.135 1.000 1.000 192 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 ASAH1(1), BRAF(10), CREB1(1), CREB5(8), MAPK1(9), RAF1(3), SNX13(2) 8458472 34 26 27 8 9 5 8 6 6 0 0.257 1.000 1.000 193 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 CDC34(4), NRF1(5), TAX1BP3(1), UBE2D2(1), UBE2D3(1), UBE2E1(1), UBE2J1(1), UBE2J2(1), UBE2L3(2), UBE2L6(2), UBE2M(2), UBE2S(1), UBE3A(6) 8012959 28 26 28 8 3 11 8 0 6 0 0.377 1.000 1.000 194 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(4), ADORA2A(2), ADORA2B(1), ADORA3(3), LTB4R(3), P2RY1(5), P2RY2(3), P2RY6(2) 4542113 23 21 22 9 4 7 8 2 2 0 0.333 1.000 1.000 195 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(4), PSMA2(1), PSMA3(2), PSMA5(1), PSMA6(2), PSMB1(1), PSMB2(1), PSMB3(1), PSMB4(2), PSMB5(3), PSMB6(1), PSMB7(1), PSMC3(2), PSMD14(1), RPN1(2), RPN2(6), UBE3A(6) 9796477 37 32 37 8 1 8 14 10 4 0 0.229 1.000 1.000 196 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD28(3), CD3D(1), IFNG(2), IL2(2), IL2RA(2), IL4(1), TGFB1(1), TGFB2(3), TGFB3(1), TGFBR1(2), TGFBR2(25), TGFBR3(5), TOB2(3) 8033948 51 46 42 13 6 12 7 13 13 0 0.212 1.000 1.000 197 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 109 ABL1(8), ANAPC1(8), ANAPC2(1), ANAPC4(2), ANAPC5(1), ANAPC7(1), ATM(16), ATR(25), BUB1(6), BUB1B(7), CCNA1(7), CCNA2(4), CCNB1(3), CCNB3(11), CCND1(4), CCND2(2), CCNE1(5), CCNE2(4), CDC14A(3), CDC14B(1), CDC16(2), CDC20(2), CDC23(4), CDC25A(2), CDC25B(4), CDC25C(4), CDC26(1), CDC27(8), CDC6(2), CDC7(1), CDK4(5), CDK6(2), CDKN1B(2), CDKN2A(114), CDKN2C(1), CHEK1(1), CHEK2(5), CREBBP(39), CUL1(11), DBF4(3), E2F2(3), E2F3(3), EP300(39), ESPL1(10), FZR1(4), GADD45A(1), GADD45G(1), GSK3B(3), HDAC1(1), HDAC2(3), MAD1L1(4), MAD2L1(1), MAD2L2(2), MCM2(4), MCM3(4), MCM4(7), MCM5(2), MCM6(4), MCM7(9), MDM2(2), PCNA(1), PKMYT1(1), PLK1(3), PRKDC(28), RB1(18), RBL1(11), RBL2(6), RBX1(3), SFN(7), SKP1(1), SKP2(4), SMAD2(4), SMAD3(4), SMAD4(14), SMC1A(3), SMC1B(7), TFDP1(2), TGFB1(1), TGFB2(3), TGFB3(1), TP53(426), WEE1(1), YWHAB(2), YWHAE(2), YWHAG(1), YWHAH(2), YWHAQ(3), YWHAZ(2) 103396057 1000 440 714 138 126 159 178 167 356 14 <1.00e-15 1.000 1.000 198 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(4), CS(2), MDH1(1), ME1(2), PC(14), PDHA1(4) 7057566 27 27 27 8 4 7 6 5 5 0 0.331 1.000 1.000 199 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 27 AKT1(2), AKT2(3), AKT3(6), BAD(1), BCL2(1), GSK3A(2), GSK3B(3), IL4R(8), IRS1(4), IRS2(6), JAK1(11), JAK3(6), MAP4K1(4), MAPK1(9), PDK1(3), PIK3CA(96), PIK3CD(8), PIK3R1(10), PPP1R13B(2), RAF1(3), SHC1(3), SOCS1(1), SOS1(9), SOS2(11), STAT6(5) 27851582 217 165 149 35 28 80 36 54 19 0 3.90e-08 1.000 1.000 200 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(4), BMPR1B(4), BMPR2(6) 4760347 14 14 14 5 3 4 4 1 2 0 0.655 1.000 1.000 201 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 LHPP(1), MTMR1(1), MTMR2(5), MTMR6(4), NFS1(1), PHPT1(1), TPK1(3) 4868352 16 14 16 5 4 2 5 3 2 0 0.699 1.000 1.000 202 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 CISH(1), IFNG(2), IFNGR1(4), JAK1(11), JAK2(5), PLA2G2A(2), PTPRU(9), REG1A(13), STAT1(7) 8690684 54 48 53 14 8 16 13 7 10 0 0.108 1.000 1.000 203 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(4), EPHA4(11), EPHB1(16), FYN(5), ITGA1(4), ITGB1(16), L1CAM(10), LYN(8), RAP1B(3), SELP(15) 12007305 92 65 90 20 13 17 24 18 20 0 0.0719 1.000 1.000 204 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RAN(2), RANBP2(14), RANGAP1(1) 6414010 17 17 17 9 3 4 5 1 4 0 0.941 1.000 1.000 205 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 33 AKT1(2), AKT2(3), AKT3(6), BCR(2), BTK(8), CD19(4), CDKN2A(114), FLOT1(2), FLOT2(4), GAB1(5), ITPR1(16), ITPR2(25), ITPR3(10), LYN(8), NR0B2(1), PDK1(3), PIK3CA(96), PITX2(2), PLCG2(9), PPP1R13B(2), PREX1(15), PTEN(14), PTPRC(19), RPS6KA1(10), RPS6KA2(6), RPS6KA3(4), RPS6KB1(5), SAG(1), SYK(8), TEC(2), VAV1(8) 41848056 414 273 292 71 35 107 59 77 132 4 3.52e-11 1.000 1.000 206 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD28(3), CD86(2), HLA-DRA(1), HLA-DRB1(2), IFNG(2), IFNGR1(4), IFNGR2(5), IL12A(1), IL12B(4), IL12RB1(4), IL12RB2(11), IL18(1), IL18R1(3), IL2(2), IL2RA(2), IL4(1), IL4R(8) 9615390 56 49 54 14 4 10 18 8 16 0 0.215 1.000 1.000 207 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 A4GALT(1), FUT2(2), FUT9(11), GBGT1(4), GLA(3), HEXA(4), NAGA(5), ST3GAL1(2), ST3GAL2(1), ST3GAL4(1), ST8SIA1(3) 7710747 37 34 37 10 7 7 14 4 5 0 0.179 1.000 1.000 208 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 ASRGL1(1), GBA(3), GGT1(4), SHMT1(1), SHMT2(2) 4189992 11 11 11 5 5 2 2 1 1 0 0.639 1.000 1.000 209 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(12), BCL2(1), BID(3), BIRC2(2), BIRC3(2), CASP10(2), CASP3(2), CASP6(5), CASP7(3), CASP8(61), CASP9(1), CFLAR(2), CHUK(6), FADD(4), GAS2(3), LMNA(1), NFKB1(5), NFKBIA(1), RELA(2), RIPK1(2), SPTAN1(24), TNFRSF10A(3), TNFRSF10B(1), TNFRSF25(2), TNFSF10(1), TRADD(1), TRAF2(2) 25457278 154 118 142 25 22 31 30 19 50 2 7.20e-05 1.000 1.000 210 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT2(2), BDH1(1), BDH2(1), HMGCL(1), HMGCS1(3), HMGCS2(2), OXCT1(2), OXCT2(1) 5469959 13 12 13 8 3 2 2 4 2 0 0.925 1.000 1.000 211 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM1(1), CALM2(2), CALM3(2), CCL2(2), CXCL12(3), CXCR4(2), FOS(6), JUN(1), MAPK14(2), MAPK8(4), PLCG1(8), PRKCA(7), PTK2B(4), SYT1(8) 10487659 52 46 52 13 7 9 19 13 4 0 0.142 1.000 1.000 212 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(7), DYRK1B(8), GLI2(15), GLI3(12), GSK3B(3), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), SHH(2), SMO(3), SUFU(3) 12661824 69 61 68 17 13 17 23 8 8 0 0.0737 1.000 1.000 213 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 B3GALT1(2), B3GALT2(2), B3GALT5(1), B3GNT5(2), FUT2(2), FUT3(3), ST3GAL3(4), ST3GAL4(1) 5501975 17 16 17 7 4 2 7 2 2 0 0.746 1.000 1.000 214 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 16 B3GAT1(2), B3GAT2(1), B3GAT3(5), B4GALT7(2), CHPF(7), CHST11(4), CHST12(5), CHST13(5), CHST14(2), CHST7(2), CHSY1(3), DSE(2), UST(3), XYLT1(10), XYLT2(3) 10680334 56 51 56 12 14 5 19 11 7 0 0.0687 1.000 1.000 215 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BAG4(6), BIRC2(2), BIRC3(2), CASP3(2), CASP8(61), CFLAR(2), FADD(4), JUN(1), MAP2K4(2), MAP3K3(3), MAP3K7(8), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(1), NFKBIE(1), NFKBIL1(1), NR2C2(1), RALBP1(5), RIPK1(2), TNFAIP3(6), TNFRSF1A(1), TNFRSF1B(2), TRADD(1), TRAF2(2) 20816367 127 102 114 24 19 28 24 15 39 2 0.00106 1.000 1.000 216 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 9 CASP3(2), CASP7(3), GZMB(2), HMGB1(1), HMGB2(2), TOP2A(5), TOP2B(4) 6712693 19 16 19 9 3 6 5 2 3 0 0.928 1.000 1.000 217 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNG(2), IL12A(1), IL12B(4), IL13(1), IL16(12), IL18(1), IL1A(1), IL2(2), IL3(1), IL4(1), IL5(2), IL6(2), IL9(2), LTA(4) 7559330 36 34 36 11 7 9 10 6 4 0 0.372 1.000 1.000 218 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(2), GNAS(12), GNB1(3), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PRKCA(7) 7309401 40 35 40 10 14 9 9 4 4 0 0.184 1.000 1.000 219 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(16), GNA12(1), PRKACB(3), PRKACG(3), PRKAR2B(3) 7645574 26 24 26 8 4 10 6 3 3 0 0.441 1.000 1.000 220 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CCNB1(3), CDC25A(2), CDC25B(4), CDC25C(4), CSK(1), PRKCA(7), PTPRA(4) 6989177 25 24 25 8 6 7 6 2 4 0 0.397 1.000 1.000 221 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 AKT1(2), AVP(1), CABIN1(15), CALM1(1), CALM2(2), CALM3(2), CAMK1(2), CAMK1G(2), HDAC5(3), IGF1(1), IGF1R(13), INSR(3), MAP2K6(1), MAPK14(2), MAPK7(6), MEF2A(3), MEF2B(5), MEF2C(15), MEF2D(1), MYOD1(2), NFATC1(9), NFATC2(15), PIK3CA(96), PIK3R1(10), PPP3CA(2), PPP3CB(1), SYT1(8), YWHAH(2) 26534412 225 169 164 44 22 82 39 60 22 0 1.04e-06 1.000 1.000 222 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(4), HK1(4), HK2(5), HK3(8), IMPA1(2), IMPA2(4), ISYNA1(4), PGM1(5), PGM3(1), TGDS(3) 8868988 40 38 40 10 9 10 10 3 8 0 0.0806 1.000 1.000 223 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(6), APOBEC1(1), APOBEC2(1), APOBEC3B(5), APOBEC3C(1), APOBEC3G(1) 5573878 15 15 15 7 2 2 6 4 1 0 0.881 1.000 1.000 224 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 A4GALT(1), B3GALNT1(1), B3GALT5(1), FUT2(2), FUT9(11), GBGT1(4), GLA(3), HEXA(4), NAGA(5), ST3GAL1(2), ST3GAL2(1), ST8SIA1(3) 8183514 38 35 38 11 7 7 15 4 5 0 0.223 1.000 1.000 225 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 42 AKT1(2), ASAH1(1), ATF1(3), BRAF(10), CREB1(1), CREB5(8), CREBBP(39), CRKL(3), DAG1(5), EGR1(4), EGR2(5), EGR4(1), ELK1(2), FRS2(2), JUN(1), MAP1B(18), MAP2K4(2), MAP2K7(2), MAPK1(9), MAPK10(4), MAPK8(4), MAPK8IP1(3), MAPK8IP2(3), MAPK8IP3(8), MAPK9(4), NTRK1(3), OPN1LW(3), PIK3C2G(13), PIK3CA(96), PIK3CD(8), PIK3R1(10), PTPN11(2), RPS6KA3(4), SHC1(3), TH(3) 39150078 289 208 219 50 37 90 56 63 42 1 6.82e-08 1.000 1.000 226 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CALM1(1), CALM2(2), CALM3(2), CAMK1(2), CAMK1G(2), CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), ESRRA(5), HDAC5(3), MEF2A(3), MEF2B(5), MEF2C(15), MEF2D(1), PPARA(2), PPP3CA(2), PPP3CB(1), SLC2A4(3), SYT1(8), YWHAH(2) 15410081 70 60 69 15 5 19 23 16 7 0 0.0329 1.000 1.000 227 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(15), CALM1(1), CALM2(2), CALM3(2), CAPN2(6), CAPNS1(2), CAPNS2(2), EP300(39), HDAC1(1), HDAC2(3), MEF2D(1), NFATC1(9), NFATC2(15), PPP3CA(2), PPP3CB(1), PRKCA(7), SYT1(8) 18568573 116 99 108 28 17 27 28 26 18 0 0.0208 1.000 1.000 228 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CCL2(2), CSF1(2), IL1B(1), MST1R(8) 4955041 13 13 13 9 1 4 7 0 1 0 0.919 1.000 1.000 229 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA1(2), ANXA3(2), ANXA4(2), ANXA6(7), CYP11A1(3), EDN1(1), EDNRA(2), EDNRB(7), HPGD(1), HSD11B2(3), PLA2G4A(3), PRL(4), PTGDR(3), PTGDS(2), PTGER2(5), PTGER4(6), PTGFR(2), PTGIR(2), PTGIS(7), PTGS1(7), PTGS2(4), TBXAS1(5) 15681651 80 68 79 20 18 13 16 12 20 1 0.0720 1.000 1.000 230 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAD(2), ALAS2(5), CPOX(1), FECH(1), PPOX(1), UROD(1), UROS(4) 5738999 15 15 15 7 1 3 5 5 1 0 0.846 1.000 1.000 231 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM1(1), CALM2(2), CALM3(2), CAMK1(2), CAMK1G(2), CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), CAMKK1(1), CAMKK2(6), CREB1(1), SYT1(8) 8786689 36 36 36 10 4 7 13 8 4 0 0.410 1.000 1.000 232 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 CISH(1), IL6(2), IL6R(5), JAK1(11), JAK2(5), JAK3(6), PIAS3(4), PTPRU(9), REG1A(13), STAT3(6) 11553078 62 58 62 16 11 11 20 12 8 0 0.125 1.000 1.000 233 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(3), LDLR(5), MBTPS1(10), MBTPS2(4), SCAP(9), SREBF1(5), SREBF2(5) 9048536 41 39 40 12 6 8 13 9 5 0 0.362 1.000 1.000 234 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CHUK(6), CREBBP(39), DUSP1(2), EP300(39), IKBKB(12), IL1B(1), MAP2K3(4), MAP2K6(1), MAP3K7(8), MAPK11(3), MAPK14(2), NFKB1(5), NFKBIA(1), NR3C1(6), RELA(2), TGFBR1(2), TGFBR2(25), TLR2(3) 22592775 161 133 143 30 23 33 36 28 40 1 0.00122 1.000 1.000 235 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 CARM1(5), DHRS1(2), DHRS2(4), DHRS3(1), DHRS7(1), HEMK1(1), LCMT1(2), LCMT2(7), METTL2B(4), METTL6(3), PRMT2(1), PRMT3(6), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(4) 11404505 49 45 49 13 10 13 11 8 7 0 0.143 1.000 1.000 236 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 51 ACTA1(4), AGT(4), AKT1(2), CALM1(1), CALM2(2), CALM3(2), CALR(2), CAMK1(2), CAMK1G(2), CREBBP(39), CSNK1A1(1), EDN1(1), ELSPBP1(2), F2(3), FGF2(1), GSK3B(3), HAND1(2), HAND2(2), HRAS(32), IGF1(1), LIF(2), MAP2K1(5), MAPK1(9), MAPK14(2), MAPK8(4), MEF2C(15), MYH2(28), NFATC1(9), NFATC2(15), NFATC3(6), NFATC4(3), NKX2-5(1), NPPA(3), PIK3CA(96), PIK3R1(10), PPP3CA(2), PPP3CB(1), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), RAF1(3), RPS6KB1(5), SYT1(8) 38646036 351 230 259 66 50 106 88 65 41 1 1.25e-08 1.000 1.000 237 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGT(4), AGTR1(14), ATF2(1), CALM1(1), CALM2(2), CALM3(2), EGFR(19), ELK1(2), HRAS(32), JUN(1), MAP2K1(5), MAP2K2(6), MAP2K4(2), MAP3K1(6), MAPK1(9), MAPK8(4), MEF2A(3), MEF2B(5), MEF2C(15), MEF2D(1), PAK1(3), PRKCA(7), PTK2(8), PTK2B(4), RAC1(15), RAF1(3), SHC1(3), SOS1(9), SYT1(8) 25435181 194 147 157 37 40 34 67 36 17 0 0.000389 1.000 1.000 238 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 CDK5(3), CDK5R1(1), DAB1(8), FYN(5), LRP8(4), RELN(53), VLDLR(5) 10640095 79 65 79 23 14 16 19 16 14 0 0.233 1.000 1.000 239 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(4), F2(3), F2R(4), F3(2), F5(20), F7(3), FGA(10), FGB(4), FGG(6), PROC(2), PROS1(9), SERPINC1(4), TFPI(2) 12450168 73 58 73 19 6 23 21 13 10 0 0.158 1.000 1.000 240 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(5), ANKRD1(1), CYR61(2), DUSP14(4), EIF4E(1), EIF4EBP1(1), IFNG(2), IFRD1(5), IL18(1), IL1A(1), IL1R1(4), JUND(1), MYOG(3), NR4A3(3), WDR1(4) 8140743 38 34 38 11 5 7 9 12 5 0 0.513 1.000 1.000 241 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(4), POLR2A(11), POLR2B(10), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(3), POLR2G(4), POLR2H(1), POLR2I(1), POLR2J(2), POLR2L(2), POLRMT(6) 10251772 47 40 47 11 3 9 18 6 11 0 0.193 1.000 1.000 242 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(5), ENO1(2), GPI(3), HK1(4), PFKL(6), PGAM1(2), PGK1(2), PKLR(3), TPI1(4) 7051136 31 30 31 10 7 8 5 4 7 0 0.355 1.000 1.000 243 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1(2), CSF1R(2), DDX20(4), E2F4(2), ETS1(4), ETS2(7), FOS(6), HDAC2(3), HDAC5(3), HRAS(32), JUN(1), NCOR2(24), RBL1(11), RBL2(6), SIN3A(6), SIN3B(11) 19785971 124 93 101 29 23 30 41 17 13 0 0.00834 1.000 1.000 244 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(4), FARSA(1), FARSB(7), GOT1(1), GOT2(3), PAH(7), TAT(1), YARS(7), YARS2(4) 6612485 35 32 35 10 2 11 12 5 5 0 0.260 1.000 1.000 245 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(4), ACTN1(4), ACTN2(11), CAPN1(3), CAPNS1(2), CAPNS2(2), ITGA1(4), ITGB1(16), ITGB3(6), PTK2(8), PXN(2), RAC1(15), SPTAN1(24), TLN1(24) 21715720 125 97 117 25 24 21 43 22 15 0 0.00605 1.000 1.000 246 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(27), ASAH1(1), CASP3(2), CERK(3), CREB1(1), CREB5(8), CXCL2(1), DAG1(5), EPHB2(3), FOS(6), ITPKB(5), JUN(1), MAP2K4(2), MAP2K7(2), MAPK1(9), MAPK10(4), MAPK8(4), MAPK8IP1(3), MAPK8IP2(3), MAPK8IP3(8), MAPK9(4) 21758164 102 84 94 21 20 25 24 15 18 0 0.0118 1.000 1.000 247 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 CISH(1), JAK1(11), JAK2(5), JAK3(6), PIAS1(1), PIAS3(4), PTPRU(9), REG1A(13), SOAT1(5) 10403694 55 51 55 15 10 10 17 9 9 0 0.246 1.000 1.000 248 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 EGFR(19), ELK1(2), GNAS(12), GNB1(3), HRAS(32), IGF1R(13), ITGB1(16), KLK2(2), MAP2K1(5), MAP2K2(6), MAPK1(9), MKNK1(1), MKNK2(2), MYC(6), NGFR(1), PDGFRA(14), PTPRR(5), RAF1(3), RPS6KA1(10), RPS6KA5(5), SHC1(3), SOS1(9), STAT3(6) 25134713 184 138 151 33 50 31 64 21 18 0 0.000115 1.000 1.000 249 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(9), EGFR(19), MAP2K1(5), MAP3K1(6), MAPK14(2), NCOR2(24), RARA(4), RXRA(5), THRA(6), THRB(1) 13131412 81 68 81 22 13 13 24 16 14 1 0.179 1.000 1.000 250 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BLNK(5), BTK(8), CALM1(1), CALM2(2), CALM3(2), CD79A(1), ELK1(2), FOS(6), HRAS(32), JUN(1), LYN(8), MAP2K1(5), MAP3K1(6), MAPK14(2), MAPK8(4), NFATC1(9), NFATC2(15), NFATC3(6), NFATC4(3), PLCG1(8), PPP3CA(2), PPP3CB(1), PRKCA(7), RAC1(15), RAF1(3), SHC1(3), SOS1(9), SYK(8), SYT1(8), VAV1(8) 29084167 190 144 160 35 42 31 61 31 24 1 0.000211 1.000 1.000 251 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(27), AXIN1(11), CREBBP(39), CTNNB1(6), DVL1(7), EP300(39), FZD1(6), GSK3B(3), HDAC1(1), LDB1(2), LEF1(5), PITX2(2), TRRAP(22), WNT1(2) 25263108 172 123 163 32 28 39 38 33 32 2 0.000166 1.000 1.000 252 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 IMPA1(2), INPP1(2), INPP4A(8), INPP4B(11), INPP5A(3), INPPL1(9), ITPKB(5), MIOX(4), OCRL(4), PIK3C2A(6), PIK3C2B(10), PIK3C2G(13), PIK3CA(96), PIK3CB(7), PIK3CG(20), PLCB1(21), PLCB2(7), PLCB3(8), PLCB4(17), PLCD1(4), PLCG1(8), PLCG2(9) 34052540 274 199 208 49 35 86 61 61 31 0 1.41e-07 1.000 1.000 253 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(11), JAK2(5), JAK3(6), MAPK1(9), STAT3(6), TYK2(8) 8892236 45 40 38 13 12 7 10 9 7 0 0.258 1.000 1.000 254 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX12(3), ALOX15B(5), ALOX5(5), DPEP1(4), GGT1(4), LTA4H(1), PLA2G2A(2), PLA2G6(3), PTGDS(2), PTGIS(7), PTGS1(7), PTGS2(4), TBXAS1(5) 11454795 52 49 52 15 10 10 15 4 13 0 0.0998 1.000 1.000 255 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 50 ACOX1(1), APOA2(1), CD36(2), CPT1B(4), CREBBP(39), DUSP1(2), EHHADH(5), EP300(39), FABP1(4), HSD17B4(5), JUN(1), LPL(4), MAPK1(9), ME1(2), MYC(6), NCOA1(7), NCOR1(21), NCOR2(24), NFKBIA(1), NR0B2(1), NR1H3(1), NR2F1(3), NRIP1(9), PIK3CA(96), PIK3R1(10), PPARA(2), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PRKCA(7), PTGS2(4), RB1(18), RELA(2), RXRA(5), SP1(3), STAT5A(3), STAT5B(5) 48149726 362 241 280 63 38 119 72 66 66 1 1.29e-09 1.000 1.000 256 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(4), APAF1(12), BCL2(1), CASP3(2), CASP9(1), DAXX(5), FAS(5), FASLG(1), HSPB2(2), IL1A(1), MAPKAPK3(4) 8603698 38 35 38 12 6 11 10 6 5 0 0.430 1.000 1.000 257 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 247 ACVR1B(5), ACVR1C(8), AKT1(2), AKT2(3), AKT3(6), ARRB1(2), ARRB2(1), ATF2(1), ATF4(5), BDNF(2), BRAF(10), CACNA1A(14), CACNA1B(13), CACNA1C(23), CACNA1D(21), CACNA1E(24), CACNA1F(11), CACNA1G(19), CACNA1H(13), CACNA1I(12), CACNA1S(16), CACNA2D1(21), CACNA2D2(3), CACNA2D3(2), CACNA2D4(7), CACNB1(5), CACNB2(6), CACNB3(3), CACNB4(2), CACNG1(1), CACNG2(3), CACNG3(3), CACNG4(7), CACNG5(4), CACNG6(5), CACNG7(4), CACNG8(8), CASP3(2), CD14(1), CDC25B(4), CDC42(3), CHUK(6), CRK(2), CRKL(3), DAXX(5), DUSP1(2), DUSP10(3), DUSP14(4), DUSP16(6), DUSP2(1), DUSP3(1), DUSP4(1), DUSP5(4), DUSP6(5), DUSP7(3), DUSP8(1), DUSP9(1), ECSIT(4), EGF(9), EGFR(19), ELK1(2), ELK4(4), FAS(5), FASLG(1), FGF1(2), FGF10(2), FGF11(1), FGF12(5), FGF13(3), FGF14(1), FGF17(2), FGF19(3), FGF2(1), FGF20(1), FGF21(1), FGF23(8), FGF3(1), FGF5(3), FGF6(1), FGF7(1), FGF8(2), FGF9(1), FGFR1(2), FGFR2(3), FGFR3(15), FGFR4(5), FLNA(23), FLNB(10), FLNC(15), FOS(6), GADD45A(1), GADD45G(1), GNA12(1), GNG12(1), HRAS(32), IKBKB(12), IL1A(1), IL1B(1), IL1R1(4), IL1R2(1), JUN(1), JUND(1), KRAS(1), MAP2K1(5), MAP2K2(6), MAP2K3(4), MAP2K4(2), MAP2K5(3), MAP2K6(1), MAP2K7(2), MAP3K1(6), MAP3K10(6), MAP3K12(8), MAP3K13(15), MAP3K2(1), MAP3K3(3), MAP3K4(14), MAP3K5(6), MAP3K6(6), MAP3K7(8), MAP3K8(4), MAP4K1(4), MAP4K2(2), MAP4K3(7), MAP4K4(4), MAPK1(9), MAPK10(4), MAPK11(3), MAPK12(3), MAPK13(3), MAPK14(2), MAPK7(6), MAPK8(4), MAPK8IP1(3), MAPK8IP2(3), MAPK8IP3(8), MAPK9(4), MAPKAPK3(4), MAPKAPK5(2), MAPT(8), MAX(1), MEF2C(15), MKNK1(1), MKNK2(2), MOS(7), MYC(6), NF1(16), NFATC2(15), NFATC4(3), NFKB1(5), NFKB2(5), NLK(1), NR4A1(2), NRAS(1), NTF3(1), NTRK1(3), NTRK2(3), PAK1(3), PAK2(8), PDGFB(1), PDGFRA(14), PDGFRB(8), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PPM1A(4), PPM1B(2), PPP3CA(2), PPP3CB(1), PPP5C(4), PRKACA(4), PRKACB(3), PRKACG(3), PRKCA(7), PRKCG(12), PRKX(1), PTPN5(1), PTPN7(4), PTPRR(5), RAC1(15), RAC2(2), RAC3(3), RAF1(3), RAP1B(3), RAPGEF2(4), RASA1(17), RASA2(8), RASGRF1(16), RASGRF2(12), RASGRP1(8), RASGRP2(6), RASGRP3(8), RASGRP4(3), RPS6KA1(10), RPS6KA2(6), RPS6KA3(4), RPS6KA4(3), RPS6KA5(5), RPS6KA6(8), RRAS(2), RRAS2(1), SOS1(9), SOS2(11), SRF(1), STK3(3), STK4(1), TAOK1(6), TAOK2(13), TAOK3(5), TGFB1(1), TGFB2(3), TGFB3(1), TGFBR1(2), TGFBR2(25), TNFRSF1A(1), TP53(426), TRAF2(2), TRAF6(3), ZAK(5) 217349265 1612 472 1336 371 307 291 406 239 356 13 2.55e-15 1.000 1.000 258 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 144 APC(27), APC2(6), AXIN1(11), AXIN2(7), BTRC(1), CACYBP(5), CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), CCND1(4), CCND2(2), CER1(1), CHD8(16), CREBBP(39), CSNK1A1(1), CSNK1A1L(4), CSNK1E(6), CSNK2A1(7), CSNK2A2(3), CSNK2B(2), CTBP1(2), CTBP2(3), CTNNB1(6), CUL1(11), CXXC4(3), DAAM1(8), DAAM2(16), DKK1(2), DKK2(5), DVL1(7), DVL2(1), DVL3(9), EP300(39), FBXW11(3), FOSL1(3), FZD1(6), FZD10(5), FZD2(4), FZD3(2), FZD4(2), FZD5(1), FZD6(5), FZD7(1), FZD8(2), FZD9(2), GSK3B(3), JUN(1), LEF1(5), LRP5(9), LRP6(17), MAP3K7(8), MAPK10(4), MAPK8(4), MAPK9(4), MMP7(1), MYC(6), NFAT5(13), NFATC1(9), NFATC2(15), NFATC3(6), NFATC4(3), NKD1(8), NKD2(3), NLK(1), PLCB1(21), PLCB2(7), PLCB3(8), PLCB4(17), PORCN(2), PPARD(1), PPP2CB(3), PPP2R1A(3), PPP2R1B(4), PPP2R2A(2), PPP2R2B(4), PPP2R2C(1), PPP3CA(2), PPP3CB(1), PRICKLE1(8), PRICKLE2(7), PRKACA(4), PRKACB(3), PRKACG(3), PRKCA(7), PRKCG(12), PRKX(1), RAC1(15), RAC2(2), RAC3(3), RBX1(3), RHOA(10), ROCK1(19), ROCK2(10), SENP2(3), SFRP1(2), SFRP4(12), SFRP5(1), SIAH1(3), SKP1(1), SMAD2(4), SMAD3(4), SMAD4(14), SOX17(3), TBL1X(6), TBL1XR1(5), TBL1Y(3), TCF7(2), TCF7L1(2), TCF7L2(1), TP53(426), VANGL1(2), VANGL2(5), WIF1(1), WNT1(2), WNT10A(2), WNT10B(1), WNT11(2), WNT16(2), WNT2(3), WNT3(4), WNT3A(1), WNT4(2), WNT5A(3), WNT5B(1), WNT6(2), WNT7A(3), WNT7B(1), WNT8A(2), WNT8B(3), WNT9A(5), WNT9B(3) 123049105 1146 459 906 209 195 197 273 185 284 12 <1.00e-15 1.000 1.000 259 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 192 ACTB(5), ACTG1(3), ACTN1(4), ACTN2(11), ACTN4(6), AKT1(2), AKT2(3), AKT3(6), ARHGAP5(10), BAD(1), BCAR1(3), BCL2(1), BIRC2(2), BIRC3(2), BRAF(10), CAPN2(6), CAV1(1), CCND1(4), CCND2(2), CDC42(3), CHAD(5), COL11A1(65), COL11A2(11), COL1A1(10), COL1A2(21), COL2A1(6), COL3A1(18), COL4A1(10), COL4A2(9), COL4A4(14), COL4A6(4), COL5A1(18), COL5A2(15), COL5A3(11), COL6A1(10), COL6A2(12), COL6A3(27), COL6A6(30), CRK(2), CRKL(3), CTNNB1(6), DIAPH1(7), DOCK1(15), EGF(9), EGFR(19), ELK1(2), ERBB2(11), FARP2(3), FIGF(1), FLNA(23), FLNB(10), FLNC(15), FLT1(17), FN1(19), FYN(5), GSK3B(3), HGF(12), HRAS(32), IBSP(3), IGF1(1), IGF1R(13), ILK(4), ITGA1(4), ITGA10(9), ITGA11(10), ITGA2(7), ITGA2B(6), ITGA3(5), ITGA4(13), ITGA5(4), ITGA6(4), ITGA7(8), ITGA8(22), ITGA9(3), ITGAV(6), ITGB1(16), ITGB3(6), ITGB4(8), ITGB5(1), ITGB6(6), ITGB7(1), ITGB8(5), JUN(1), KDR(13), LAMA1(33), LAMA2(46), LAMA3(19), LAMA4(25), LAMA5(17), LAMB1(9), LAMB2(6), LAMB3(5), LAMB4(18), LAMC1(13), LAMC2(5), LAMC3(9), MAP2K1(5), MAPK1(9), MAPK10(4), MAPK8(4), MAPK9(4), MET(4), MYL7(2), MYL9(4), MYLK(8), MYLK2(5), PAK1(3), PAK2(8), PAK3(4), PAK4(1), PAK6(5), PAK7(9), PARVB(1), PARVG(2), PDGFB(1), PDGFC(3), PDGFD(6), PDGFRA(14), PDGFRB(8), PDPK1(4), PIK3CA(96), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PIP5K1C(2), PPP1CA(1), PPP1R12A(5), PRKCA(7), PRKCG(12), PTEN(14), PTK2(8), PXN(2), RAC1(15), RAC2(2), RAC3(3), RAF1(3), RAP1B(3), RAPGEF1(5), RELN(53), RHOA(10), ROCK1(19), ROCK2(10), SHC1(3), SHC2(5), SHC3(6), SHC4(4), SOS1(9), SOS2(11), SPP1(2), THBS1(8), THBS2(11), THBS3(4), THBS4(7), TLN1(24), TLN2(13), TNC(12), TNN(23), TNR(19), TNXB(23), VASP(1), VAV1(8), VAV2(4), VAV3(4), VCL(6), VEGFB(1), VEGFC(6), VTN(2), VWF(19), ZYX(2) 282453904 1670 439 1556 481 258 388 506 265 247 6 4.22e-05 1.000 1.000 260 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 203 ABI2(3), ACTN1(4), ACTN2(11), ACTN4(6), APC(27), APC2(6), ARAF(2), ARHGEF1(9), ARHGEF12(12), ARHGEF4(5), ARHGEF6(7), ARHGEF7(2), ARPC1B(3), ARPC2(2), ARPC3(1), ARPC4(1), BAIAP2(2), BCAR1(3), BDKRB1(3), BDKRB2(3), BRAF(10), CD14(1), CDC42(3), CFL1(2), CHRM2(5), CHRM3(9), CHRM4(2), CHRM5(3), CRK(2), CRKL(3), CSK(1), CYFIP1(9), CYFIP2(9), DIAPH1(7), DIAPH2(10), DIAPH3(12), DOCK1(15), EGF(9), EGFR(19), F2(3), F2R(4), FGD1(12), FGD3(5), FGF1(2), FGF10(2), FGF11(1), FGF12(5), FGF13(3), FGF14(1), FGF17(2), FGF19(3), FGF2(1), FGF20(1), FGF21(1), FGF23(8), FGF3(1), FGF5(3), FGF6(1), FGF7(1), FGF8(2), FGF9(1), FGFR1(2), FGFR2(3), FGFR3(15), FGFR4(5), FN1(19), GIT1(5), GNA12(1), GNA13(2), GNG12(1), GSN(5), HRAS(32), IQGAP1(11), IQGAP2(6), IQGAP3(10), ITGA1(4), ITGA10(9), ITGA11(10), ITGA2(7), ITGA2B(6), ITGA3(5), ITGA4(13), ITGA5(4), ITGA6(4), ITGA7(8), ITGA8(22), ITGA9(3), ITGAD(7), ITGAE(4), ITGAL(7), ITGAM(8), ITGAV(6), ITGAX(7), ITGB1(16), ITGB2(4), ITGB3(6), ITGB4(8), ITGB5(1), ITGB6(6), ITGB7(1), ITGB8(5), KRAS(1), LIMK1(5), LIMK2(6), MAP2K1(5), MAP2K2(6), MAPK1(9), MOS(7), MSN(3), MYH10(24), MYH14(7), MYH9(24), MYL7(2), MYL9(4), MYLK(8), MYLK2(5), NCKAP1(8), NCKAP1L(8), NRAS(1), PAK1(3), PAK2(8), PAK3(4), PAK4(1), PAK6(5), PAK7(9), PDGFB(1), PDGFRA(14), PDGFRB(8), PFN1(1), PFN4(1), PIK3CA(96), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PIP4K2B(3), PIP4K2C(3), PIP5K1A(4), PIP5K1B(8), PIP5K1C(2), PPP1CA(1), PPP1R12A(5), PPP1R12B(4), PTK2(8), PXN(2), RAC1(15), RAC2(2), RAC3(3), RAF1(3), RDX(1), RHOA(10), ROCK1(19), ROCK2(10), RRAS(2), RRAS2(1), SCIN(5), SLC9A1(4), SOS1(9), SOS2(11), SSH1(7), SSH2(7), SSH3(5), TIAM1(15), TIAM2(13), TMSB4Y(1), VAV1(8), VAV2(4), VAV3(4), VCL(6), WAS(2), WASF1(3), WASF2(5), WASL(2) 210031774 1171 403 1058 351 209 269 324 199 168 2 0.00129 1.000 1.000 261 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 168 ADCY1(21), ADCY2(29), ADCY3(8), ADCY4(8), ADCY7(5), ADCY8(28), ADCY9(9), ADORA2A(2), ADORA2B(1), ADRA1A(5), ADRA1B(3), ADRA1D(3), ADRB1(3), ADRB3(2), AGTR1(14), ATP2A1(8), ATP2A2(7), ATP2A3(6), ATP2B1(7), ATP2B2(6), ATP2B3(15), ATP2B4(6), AVPR1A(9), AVPR1B(7), BDKRB1(3), BDKRB2(3), BST1(2), CACNA1A(14), CACNA1B(13), CACNA1C(23), CACNA1D(21), CACNA1E(24), CACNA1F(11), CACNA1G(19), CACNA1H(13), CACNA1I(12), CACNA1S(16), CALM1(1), CALM2(2), CALM3(2), CALML3(1), CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), CCKAR(5), CCKBR(5), CD38(5), CHRM2(5), CHRM3(9), CHRM5(3), CHRNA7(2), CYSLTR1(2), CYSLTR2(5), DRD1(2), EDNRA(2), EDNRB(7), EGFR(19), ERBB2(11), ERBB3(14), ERBB4(21), F2R(4), GNA11(4), GNA14(3), GNA15(4), GNAL(4), GNAS(12), GRIN1(4), GRIN2A(21), GRIN2C(7), GRIN2D(6), GRM1(29), GRM5(12), GRPR(1), HRH1(1), HRH2(3), HTR2A(5), HTR2B(2), HTR2C(3), HTR4(2), HTR5A(8), HTR6(6), HTR7(7), ITPKB(5), ITPR1(16), ITPR2(25), ITPR3(10), LHCGR(9), LTB4R2(3), MYLK(8), MYLK2(5), NOS1(9), NOS3(4), NTSR1(3), OXTR(2), P2RX1(4), P2RX2(3), P2RX3(4), P2RX4(3), P2RX5(2), P2RX7(1), PDE1A(6), PDE1B(4), PDE1C(14), PDGFRA(14), PDGFRB(8), PHKA1(4), PHKA2(9), PHKB(3), PHKG1(3), PHKG2(2), PLCB1(21), PLCB2(7), PLCB3(8), PLCB4(17), PLCD1(4), PLCD3(2), PLCD4(2), PLCE1(21), PLCG1(8), PLCG2(9), PLCZ1(7), PPP3CA(2), PPP3CB(1), PRKACA(4), PRKACB(3), PRKACG(3), PRKCA(7), PRKCG(12), PRKX(1), PTGER3(6), PTGFR(2), PTK2B(4), RYR1(34), RYR2(79), RYR3(37), SLC25A6(4), SLC8A1(14), SLC8A2(6), SLC8A3(16), SPHK2(3), TACR1(3), TACR2(4), TACR3(6), TBXA2R(1), TNNC2(1), TRHR(7), TRPC1(10) 204682270 1227 398 1220 428 257 260 352 204 153 1 0.00847 1.000 1.000 262 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 236 ADCYAP1R1(7), ADORA1(4), ADORA2A(2), ADORA2B(1), ADORA3(3), ADRA1A(5), ADRA1B(3), ADRA2B(4), ADRA2C(3), ADRB1(3), ADRB3(2), AGTR1(14), AGTR2(2), AVPR1A(9), AVPR1B(7), AVPR2(2), BDKRB1(3), BDKRB2(3), BRS3(3), C3AR1(5), C5AR1(2), CALCR(4), CALCRL(5), CCKAR(5), CCKBR(5), CGA(1), CHRM2(5), CHRM3(9), CHRM4(2), CHRM5(3), CNR1(4), CRHR1(3), CRHR2(4), CTSG(1), CYSLTR1(2), CYSLTR2(5), DRD1(2), DRD2(4), DRD3(6), DRD4(1), DRD5(8), EDNRA(2), EDNRB(7), F2(3), F2R(4), F2RL1(1), F2RL2(2), F2RL3(3), FPR1(7), FSHB(2), FSHR(12), GABBR1(3), GABBR2(6), GABRA1(11), GABRA2(13), GABRA3(7), GABRA4(5), GABRA5(6), GABRA6(6), GABRB1(8), GABRB2(8), GABRB3(14), GABRD(2), GABRE(8), GABRG1(10), GABRG2(8), GABRG3(7), GABRP(6), GABRQ(10), GABRR1(4), GABRR2(3), GALR1(4), GALR2(4), GALR3(2), GH1(4), GH2(4), GHR(8), GHRHR(4), GHSR(3), GIPR(2), GLP1R(2), GLP2R(3), GLRA1(3), GLRA2(5), GLRA3(4), GLRB(4), GNRHR(2), GPR156(5), GPR35(2), GPR50(6), GPR63(6), GPR83(1), GRIA1(17), GRIA2(16), GRIA3(8), GRIA4(11), GRID1(20), GRID2(21), GRIK1(8), GRIK2(15), GRIK3(8), GRIK4(6), GRIK5(9), GRIN1(4), GRIN2A(21), GRIN2B(23), GRIN2C(7), GRIN2D(6), GRIN3A(17), GRIN3B(5), GRM1(29), GRM2(10), GRM3(29), GRM4(2), GRM5(12), GRM6(4), GRM7(19), GRM8(23), GRPR(1), GZMA(2), HCRTR1(3), HCRTR2(7), HRH1(1), HRH2(3), HRH3(3), HRH4(3), HTR1A(9), HTR1B(7), HTR1D(2), HTR1E(8), HTR1F(4), HTR2A(5), HTR2B(2), HTR2C(3), HTR4(2), HTR5A(8), HTR6(6), HTR7(7), LEP(1), LEPR(20), LHB(2), LHCGR(9), LTB4R(3), LTB4R2(3), MAS1(2), MC1R(2), MC2R(7), MC3R(4), MC4R(4), MC5R(9), MCHR1(3), MCHR2(5), MLNR(4), MTNR1A(3), MTNR1B(3), NMBR(3), NMUR1(5), NMUR2(1), NPBWR1(1), NPBWR2(4), NPFFR2(17), NPY1R(6), NPY2R(5), NPY5R(8), NR3C1(6), NTSR1(3), NTSR2(6), OPRD1(2), OPRK1(7), OPRL1(6), OPRM1(4), OXTR(2), P2RX1(4), P2RX2(3), P2RX3(4), P2RX4(3), P2RX5(2), P2RX7(1), P2RY1(5), P2RY10(5), P2RY11(3), P2RY13(3), P2RY14(1), P2RY2(3), P2RY6(2), P2RY8(3), PARD3(15), PRL(4), PRLHR(5), PRLR(8), PRSS1(10), PRSS3(1), PTGDR(3), PTGER2(5), PTGER3(6), PTGER4(6), PTGFR(2), PTGIR(2), PTH2R(12), RXFP1(5), RXFP2(9), SCTR(2), SSTR1(8), SSTR2(3), SSTR3(6), SSTR4(7), SSTR5(2), TAAR1(5), TAAR2(2), TAAR5(1), TAAR6(1), TAAR8(1), TACR1(3), TACR2(4), TACR3(6), TBXA2R(1), THRA(6), THRB(1), TRHR(7), TRPV1(7), TSHB(2), TSHR(4), UTS2R(3), VIPR1(1), VIPR2(6) 168761211 1262 393 1255 442 223 237 425 214 162 1 0.0153 1.000 1.000 263 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 127 ABL1(8), ABLIM1(7), ABLIM2(5), ABLIM3(5), ARHGEF12(12), CDC42(3), CDK5(3), CFL1(2), CXCL12(3), CXCR4(2), DCC(31), DPYSL2(5), DPYSL5(5), EFNA1(2), EFNA3(1), EFNA5(3), EFNB1(4), EFNB2(1), EFNB3(3), EPHA1(8), EPHA2(27), EPHA3(19), EPHA4(11), EPHA5(25), EPHA6(18), EPHA7(24), EPHA8(5), EPHB1(16), EPHB2(3), EPHB3(9), EPHB4(8), EPHB6(7), FES(6), FYN(5), GNAI1(2), GNAI2(1), GNAI3(1), GSK3B(3), HRAS(32), ITGB1(16), KRAS(1), L1CAM(10), LIMK1(5), LIMK2(6), LRRC4C(29), MAPK1(9), MET(4), NCK1(5), NCK2(7), NFAT5(13), NFATC1(9), NFATC2(15), NFATC3(6), NFATC4(3), NGEF(3), NRAS(1), NRP1(6), NTN1(3), NTN4(2), NTNG1(3), PAK1(3), PAK2(8), PAK3(4), PAK4(1), PAK6(5), PAK7(9), PLXNA1(24), PLXNA2(17), PLXNA3(15), PLXNB1(7), PLXNB2(17), PLXNB3(9), PLXNC1(9), PPP3CA(2), PPP3CB(1), PTK2(8), RAC1(15), RAC2(2), RAC3(3), RASA1(17), RGS3(10), RHOA(10), RHOD(1), ROBO1(12), ROBO2(16), ROBO3(6), ROCK1(19), ROCK2(10), SEMA3A(14), SEMA3C(8), SEMA3D(5), SEMA3E(12), SEMA3F(4), SEMA3G(4), SEMA4A(5), SEMA4B(1), SEMA4C(3), SEMA4D(8), SEMA4F(5), SEMA4G(8), SEMA5A(28), SEMA5B(13), SEMA6A(3), SEMA6B(6), SEMA6C(1), SEMA6D(11), SEMA7A(4), SLIT1(10), SLIT2(25), SLIT3(9), SRGAP1(11), SRGAP2(2), SRGAP3(7), UNC5A(5), UNC5B(8), UNC5C(20), UNC5D(20) 149810079 1011 375 959 282 165 191 315 162 173 5 0.000104 1.000 1.000 264 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 ACTB(5), ACTG1(3), CHAD(5), COL11A1(65), COL11A2(11), COL17A1(11), COL1A1(10), COL1A2(21), COL2A1(6), COL3A1(18), COL4A1(10), COL4A2(9), COL4A4(14), COL4A6(4), COL5A1(18), COL5A2(15), COL5A3(11), COL6A1(10), COL6A2(12), COL6A3(27), COL6A6(30), DES(3), DSC1(4), DSC2(8), DSC3(1), DSG1(9), DSG2(3), DSG3(2), DSG4(5), FN1(19), GJA1(2), GJA10(7), GJA3(2), GJA4(1), GJA5(6), GJA8(8), GJA9(2), GJB3(1), GJB4(2), GJB7(1), GJC1(4), GJC3(2), GJD2(2), IBSP(3), ITGA6(4), ITGB4(8), KRT1(2), KRT10(5), KRT12(8), KRT13(4), KRT14(11), KRT15(2), KRT16(2), KRT18(1), KRT19(1), KRT2(3), KRT20(1), KRT23(4), KRT24(6), KRT25(6), KRT27(3), KRT28(6), KRT3(5), KRT31(3), KRT32(2), KRT33A(4), KRT33B(4), KRT34(4), KRT35(4), KRT36(6), KRT37(2), KRT38(5), KRT39(5), KRT4(6), KRT40(5), KRT5(11), KRT6A(4), KRT6B(2), KRT6C(3), KRT7(2), KRT71(3), KRT72(4), KRT73(4), KRT74(7), KRT75(5), KRT76(3), KRT77(3), KRT78(8), KRT79(4), KRT8(1), KRT82(7), KRT83(6), KRT84(1), KRT85(5), KRT86(4), KRT9(3), LAMA1(33), LAMA2(46), LAMA3(19), LAMA4(25), LAMA5(17), LAMB1(9), LAMB2(6), LAMB3(5), LAMB4(18), LAMC1(13), LAMC2(5), LAMC3(9), LMNA(1), LMNB1(1), LMNB2(8), NES(13), RELN(53), SPP1(2), THBS1(8), THBS2(11), THBS3(4), THBS4(7), TNC(12), TNN(23), TNR(19), TNXB(23), VIM(4), VTN(2), VWF(19) 189768350 1049 361 1043 361 175 214 353 148 154 5 0.356 1.000 1.000 265 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(9), CD36(2), CD44(3), CD47(1), CHAD(5), COL11A1(65), COL11A2(11), COL1A1(10), COL1A2(21), COL2A1(6), COL3A1(18), COL4A1(10), COL4A2(9), COL4A4(14), COL4A6(4), COL5A1(18), COL5A2(15), COL5A3(11), COL6A1(10), COL6A2(12), COL6A3(27), COL6A6(30), DAG1(5), FN1(19), FNDC1(13), FNDC3A(11), FNDC4(3), FNDC5(1), GP5(4), GP6(1), GP9(2), HMMR(2), HSPG2(23), IBSP(3), ITGA1(4), ITGA10(9), ITGA11(10), ITGA2(7), ITGA2B(6), ITGA3(5), ITGA4(13), ITGA5(4), ITGA6(4), ITGA7(8), ITGA8(22), ITGA9(3), ITGAV(6), ITGB1(16), ITGB3(6), ITGB4(8), ITGB5(1), ITGB6(6), ITGB7(1), ITGB8(5), LAMA1(33), LAMA2(46), LAMA3(19), LAMA4(25), LAMA5(17), LAMB1(9), LAMB2(6), LAMB3(5), LAMB4(18), LAMC1(13), LAMC2(5), LAMC3(9), RELN(53), SDC1(2), SDC2(2), SDC3(2), SDC4(1), SPP1(2), SV2A(5), SV2B(3), SV2C(4), THBS1(8), THBS2(11), THBS3(4), THBS4(7), TNC(12), TNN(23), TNR(19), TNXB(23), VTN(2), VWF(19) 170769936 949 351 943 318 153 205 299 141 147 4 0.288 1.000 1.000 266 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 131 ACTB(5), ACTG1(3), ACTN1(4), ACTN2(11), ACTN4(6), AKT1(2), AKT2(3), AKT3(6), AMOTL1(5), ASH1L(20), CASK(4), CDC42(3), CDK4(5), CGN(5), CLDN10(4), CLDN11(1), CLDN15(3), CLDN16(6), CLDN17(3), CLDN18(3), CLDN2(2), CLDN22(2), CLDN23(1), CLDN4(1), CLDN6(2), CLDN7(1), CLDN8(1), CLDN9(1), CRB3(2), CSNK2A1(7), CSNK2A2(3), CSNK2B(2), CTNNA1(8), CTNNA2(29), CTNNA3(13), CTNNB1(6), CTTN(10), EPB41(4), EPB41L1(7), EPB41L2(12), EPB41L3(23), EXOC3(3), EXOC4(15), F11R(3), GNAI1(2), GNAI2(1), GNAI3(1), HCLS1(2), HRAS(32), IGSF5(4), INADL(11), JAM2(2), KRAS(1), LLGL1(2), LLGL2(6), MAGI1(14), MAGI2(20), MAGI3(14), MLLT4(13), MPDZ(15), MPP5(7), MYH1(22), MYH10(24), MYH11(11), MYH13(28), MYH14(7), MYH15(14), MYH2(28), MYH3(14), MYH4(19), MYH6(20), MYH7(16), MYH7B(6), MYH8(26), MYH9(24), MYL7(2), MYL9(4), NRAS(1), OCLN(1), PARD3(15), PARD6A(1), PARD6B(1), PARD6G(6), PPP2CB(3), PPP2R1A(3), PPP2R1B(4), PPP2R2A(2), PPP2R2B(4), PPP2R2C(1), PPP2R3A(13), PPP2R3B(5), PPP2R4(2), PRKCA(7), PRKCD(4), PRKCE(3), PRKCG(12), PRKCH(4), PRKCI(3), PRKCQ(8), PRKCZ(3), PTEN(14), RAB13(2), RHOA(10), RRAS(2), RRAS2(1), SPTAN1(24), SYMPK(7), TJAP1(4), TJP1(12), TJP2(5), TJP3(6), VAPA(1), YES1(2), ZAK(5) 147623367 873 346 835 259 147 189 274 137 124 2 0.00471 1.000 1.000 267 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(21), ADCY2(29), ADCY3(8), ADCY4(8), ADCY5(10), ADCY6(6), ADCY7(5), ADCY8(28), ADCY9(9), ADRA1A(5), ADRA1B(3), ADRA1D(3), ADRB1(3), ADRB3(2), ANXA6(7), ARRB1(2), ARRB2(1), ATP1A4(5), ATP1B1(2), ATP1B2(2), ATP1B3(4), ATP2A2(7), ATP2A3(6), ATP2B1(7), ATP2B2(6), ATP2B3(15), CACNA1A(14), CACNA1B(13), CACNA1C(23), CACNA1D(21), CACNA1E(24), CACNA1S(16), CACNB1(5), CACNB3(3), CALM1(1), CALM2(2), CALM3(2), CALR(2), CAMK1(2), CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), CASQ1(3), CASQ2(4), CHRM2(5), CHRM3(9), CHRM4(2), CHRM5(3), GJA1(2), GJA4(1), GJA5(6), GJB3(1), GJB4(2), GNA11(4), GNAI2(1), GNAI3(1), GNAO1(1), GNAZ(7), GNB1(3), GNB2(4), GNB3(6), GNB4(2), GNB5(2), GNG12(1), GNG13(2), GNG2(1), GRK4(1), GRK5(6), ITPR1(16), ITPR2(25), ITPR3(10), KCNB1(3), KCNJ3(11), KCNJ5(3), MIB1(5), NME7(4), PEA15(1), PKIG(1), PLCB3(8), PRKACA(4), PRKACB(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PRKCA(7), PRKCD(4), PRKCE(3), PRKCG(12), PRKCH(4), PRKCQ(8), PRKCZ(3), PRKD1(15), RGS1(3), RGS11(2), RGS14(2), RGS16(1), RGS17(5), RGS18(4), RGS19(2), RGS2(1), RGS20(4), RGS3(10), RGS4(2), RGS5(3), RGS6(5), RGS7(17), RGS9(7), RYR1(34), RYR2(79), RYR3(37), SFN(7), SLC8A1(14), SLC8A3(16), USP5(5), YWHAB(2), YWHAH(2), YWHAQ(3) 142455442 850 345 845 305 179 190 233 136 110 2 0.0560 1.000 1.000 268 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA1(4), ACTA2(3), ADCY1(21), ADCY2(29), ADCY3(8), ADCY4(8), ADCY5(10), ADCY6(6), ADCY7(5), ADCY8(28), ADCY9(9), ADM(1), ARRB1(2), ARRB2(1), ATF1(3), ATF2(1), ATF4(5), ATF5(2), ATP2A2(7), ATP2A3(6), CACNB3(3), CALCA(1), CALM1(1), CALM2(2), CALM3(2), CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), CNN1(1), CNN2(1), CORIN(6), CRH(1), CRHR1(3), DGKZ(7), ETS2(7), FOS(6), GABPA(3), GABPB2(1), GBA2(6), GJA1(2), GNB1(3), GNB2(4), GNB3(6), GNB4(2), GNB5(2), GNG12(1), GNG13(2), GNG2(1), GRK4(1), GRK5(6), GSTO1(2), GUCA2A(1), GUCY1A3(9), IGFBP1(3), IGFBP2(1), IGFBP3(1), IGFBP4(1), IL1B(1), IL6(2), ITPR1(16), ITPR2(25), ITPR3(10), JUN(1), MIB1(5), MYL4(2), MYLK2(5), NFKB1(5), NOS1(9), NOS3(4), OXTR(2), PDE4B(7), PDE4D(7), PKIG(1), PLCB3(8), PLCD1(4), PLCG1(8), PLCG2(9), PRKACA(4), PRKACB(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PRKCA(7), PRKCD(4), PRKCE(3), PRKCH(4), PRKCQ(8), PRKCZ(3), PRKD1(15), RAMP1(1), RGS1(3), RGS11(2), RGS14(2), RGS16(1), RGS17(5), RGS18(4), RGS19(2), RGS2(1), RGS20(4), RGS3(10), RGS4(2), RGS5(3), RGS6(5), RGS7(17), RGS9(7), RYR1(34), RYR2(79), RYR3(37), SFN(7), SLC8A1(14), SP1(3), TNXB(23), USP5(5), YWHAB(2), YWHAH(2), YWHAQ(3) 131546288 739 329 736 261 141 176 207 118 95 2 0.101 1.000 1.000 269 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 151 AKT1(2), AKT2(3), AKT3(6), BCL2L1(2), CBL(3), CBLB(7), CBLC(1), CCND1(4), CCND2(2), CISH(1), CNTFR(1), CREBBP(39), CRLF2(4), CSF2RA(1), CSF2RB(8), CSF3R(3), EP300(39), EPO(2), EPOR(2), GH1(4), GH2(4), GHR(8), IFNA10(1), IFNA14(1), IFNA16(4), IFNA17(3), IFNA2(1), IFNA21(2), IFNA4(4), IFNA6(1), IFNA8(3), IFNAR1(3), IFNAR2(2), IFNG(2), IFNGR1(4), IFNGR2(5), IFNK(1), IFNW1(2), IL10RA(5), IL10RB(2), IL11RA(2), IL12A(1), IL12B(4), IL12RB1(4), IL12RB2(11), IL13(1), IL13RA1(2), IL13RA2(4), IL19(4), IL2(2), IL20RA(3), IL21(3), IL21R(5), IL22(2), IL22RA1(4), IL22RA2(1), IL23R(2), IL24(2), IL26(2), IL2RA(2), IL2RB(3), IL3(1), IL3RA(6), IL4(1), IL4R(8), IL5(2), IL5RA(3), IL6(2), IL6R(5), IL6ST(4), IL7(1), IL7R(6), IL9(2), IL9R(6), IRF9(2), JAK1(11), JAK2(5), JAK3(6), LEP(1), LEPR(20), LIF(2), LIFR(13), MPL(4), MYC(6), OSMR(4), PIAS1(1), PIAS2(3), PIAS3(4), PIAS4(3), PIK3CA(96), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PIM1(3), PRL(4), PRLR(8), PTPN11(2), PTPN6(2), SOCS1(1), SOCS2(1), SOCS3(1), SOCS4(2), SOCS5(7), SOCS7(2), SOS1(9), SOS2(11), SPRED1(3), SPRED2(5), SPRY1(3), SPRY2(2), SPRY3(3), SPRY4(2), STAM(2), STAM2(3), STAT1(7), STAT2(5), STAT3(6), STAT4(6), STAT5A(3), STAT5B(5), STAT6(5), TPO(11), TSLP(1), TYK2(8) 110583230 683 328 607 172 77 183 182 144 96 1 1.22e-05 1.000 1.000 270 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 131 ACACA(15), ACACB(20), AKT1(2), AKT2(3), AKT3(6), ARAF(2), BAD(1), BRAF(10), CALM1(1), CALM2(2), CALM3(2), CALML3(1), CBL(3), CBLB(7), CBLC(1), CRK(2), CRKL(3), EIF4EBP1(1), ELK1(2), FASN(10), FBP2(1), FLOT1(2), FLOT2(4), FOXO1(3), G6PC(2), G6PC2(7), GCK(4), GSK3B(3), GYS1(6), GYS2(7), HRAS(32), IKBKB(12), INPP5D(9), INSR(3), IRS1(4), IRS2(6), IRS4(16), KRAS(1), LIPE(8), MAP2K1(5), MAP2K2(6), MAPK1(9), MAPK10(4), MAPK8(4), MAPK9(4), MKNK1(1), MKNK2(2), NRAS(1), PCK1(1), PCK2(4), PDE3A(18), PDE3B(4), PDPK1(4), PFKL(6), PFKM(6), PFKP(6), PHKA1(4), PHKA2(9), PHKB(3), PHKG1(3), PHKG2(2), PIK3CA(96), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PKLR(3), PPARGC1A(6), PPP1CA(1), PPP1R3A(13), PPP1R3B(3), PPP1R3C(2), PPP1R3D(3), PRKAA1(4), PRKAA2(4), PRKAB1(4), PRKAB2(2), PRKACA(4), PRKACB(3), PRKACG(3), PRKAG2(2), PRKAG3(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PRKCI(3), PRKCZ(3), PRKX(1), PTPN1(3), PTPRF(17), PYGB(5), PYGL(9), PYGM(8), RAF1(3), RAPGEF1(5), RHEB(1), RHOQ(1), RPS6KB1(5), RPS6KB2(2), SH2B2(1), SHC1(3), SHC2(5), SHC3(6), SHC4(4), SLC2A4(3), SOCS1(1), SOCS2(1), SOCS3(1), SOCS4(2), SORBS1(7), SOS1(9), SOS2(11), SREBF1(5), TRIP10(6), TSC1(4), TSC2(8) 121848627 705 324 609 190 132 174 181 128 90 0 2.47e-05 1.000 1.000 271 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 78 ABL1(8), ACTN1(4), ACTR2(1), AKT1(2), AKT2(3), AKT3(6), ANGPTL2(3), ARHGEF6(7), ARHGEF7(2), BCAR1(3), BRAF(10), CAV1(1), CDC42(3), CDKN2A(114), CRK(2), CSE1L(2), DOCK1(15), EPHB2(3), FYN(5), GRB7(1), ILK(4), ITGA1(4), ITGA10(9), ITGA11(10), ITGA2(7), ITGA3(5), ITGA4(13), ITGA5(4), ITGA6(4), ITGA7(8), ITGA8(22), ITGA9(3), ITGB3BP(1), MAP2K4(2), MAP2K7(2), MAP3K11(2), MAPK1(9), MAPK10(4), MAPK8(4), MAPK8IP1(3), MAPK8IP2(3), MAPK8IP3(8), MAPK9(4), MYLK(8), MYLK2(5), P4HB(1), PAK1(3), PAK2(8), PAK3(4), PAK4(1), PAK6(5), PAK7(9), PIK3CA(96), PIK3CB(7), PKLR(3), PLCG1(8), PLCG2(9), PTEN(14), PTK2(8), RAF1(3), RHO(3), ROCK1(19), ROCK2(10), SHC1(3), SOS1(9), SOS2(11), TLN1(24), TLN2(13), VASP(1), WAS(2), ZYX(2) 93006234 619 323 489 140 76 128 137 113 162 3 7.14e-07 1.000 1.000 272 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 250 ACVR1(5), ACVR1B(5), ACVR2A(1), ACVR2B(1), AMHR2(1), BMP2(5), BMP7(3), BMPR1B(4), BMPR2(6), CCL1(4), CCL15(1), CCL16(1), CCL2(2), CCL20(1), CCL23(3), CCL24(1), CCL25(3), CCL28(1), CCL3(1), CCL8(3), CCR1(1), CCR2(4), CCR3(6), CCR4(4), CCR6(2), CCR7(2), CCR9(2), CD27(3), CD40(7), CD40LG(5), CNTFR(1), CRLF2(4), CSF1(2), CSF1R(2), CSF2RA(1), CSF2RB(8), CSF3R(3), CX3CL1(3), CX3CR1(1), CXCL1(3), CXCL10(2), CXCL12(3), CXCL13(1), CXCL14(1), CXCL2(1), CXCL3(1), CXCL5(1), CXCL9(3), CXCR3(1), CXCR4(2), EDA(4), EDA2R(1), EDAR(2), EGF(9), EGFR(19), EPO(2), EPOR(2), FAS(5), FASLG(1), FLT1(17), FLT3(6), FLT3LG(1), FLT4(13), GDF5(4), GH1(4), GH2(4), GHR(8), HGF(12), IFNA10(1), IFNA14(1), IFNA16(4), IFNA17(3), IFNA2(1), IFNA21(2), IFNA4(4), IFNA6(1), IFNA8(3), IFNAR1(3), IFNAR2(2), IFNG(2), IFNGR1(4), IFNGR2(5), IFNK(1), IFNW1(2), IL10RA(5), IL10RB(2), IL11RA(2), IL12A(1), IL12B(4), IL12RB1(4), IL12RB2(11), IL13(1), IL13RA1(2), IL17A(3), IL17B(1), IL17RA(6), IL17RB(4), IL18(1), IL18R1(3), IL18RAP(6), IL19(4), IL1A(1), IL1B(1), IL1R1(4), IL1R2(1), IL1RAP(6), IL2(2), IL20RA(3), IL21(3), IL21R(5), IL22(2), IL22RA1(4), IL22RA2(1), IL23R(2), IL24(2), IL25(1), IL26(2), IL2RA(2), IL2RB(3), IL3(1), IL3RA(6), IL4(1), IL4R(8), IL5(2), IL5RA(3), IL6(2), IL6R(5), IL6ST(4), IL7(1), IL7R(6), IL9(2), IL9R(6), INHBA(4), INHBB(4), INHBC(3), INHBE(1), KDR(13), KIT(11), KITLG(1), LEP(1), LEPR(20), LIF(2), LIFR(13), LTA(4), LTBR(6), MET(4), MPL(4), NGFR(1), OSMR(4), PDGFB(1), PDGFC(3), PDGFRA(14), PDGFRB(8), PF4V1(1), PLEKHO2(2), PPBP(1), PRL(4), PRLR(8), RELT(5), TGFB1(1), TGFB2(3), TGFB3(1), TGFBR1(2), TGFBR2(25), TNFRSF10A(3), TNFRSF10B(1), TNFRSF10D(1), TNFRSF11A(3), TNFRSF11B(2), TNFRSF13B(1), TNFRSF13C(2), TNFRSF14(1), TNFRSF19(4), TNFRSF1A(1), TNFRSF1B(2), TNFRSF21(6), TNFRSF25(2), TNFRSF4(2), TNFRSF6B(4), TNFRSF8(2), TNFRSF9(4), TNFSF10(1), TNFSF11(1), TNFSF13(1), TNFSF13B(2), TNFSF14(2), TNFSF15(1), TNFSF18(1), TNFSF4(3), TNFSF8(2), TNFSF9(1), TPO(11), TSLP(1), VEGFB(1), VEGFC(6), XCL1(1), XCL2(1), XCR1(3) 134718817 692 308 679 232 106 138 215 125 107 1 0.249 1.000 1.000 273 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 130 ALCAM(7), CADM1(4), CADM3(5), CD2(1), CD22(3), CD226(5), CD274(1), CD276(1), CD28(3), CD34(6), CD4(1), CD40(7), CD40LG(5), CD58(2), CD6(1), CD80(5), CD86(2), CD8A(2), CD8B(2), CDH1(5), CDH15(3), CDH2(6), CDH3(8), CDH4(8), CDH5(7), CLDN10(4), CLDN11(1), CLDN15(3), CLDN16(6), CLDN17(3), CLDN18(3), CLDN2(2), CLDN22(2), CLDN23(1), CLDN4(1), CLDN6(2), CLDN7(1), CLDN8(1), CLDN9(1), CNTN1(10), CNTN2(8), CNTNAP1(9), CNTNAP2(27), CTLA4(2), ESAM(4), F11R(3), GLG1(4), HLA-A(24), HLA-B(26), HLA-C(5), HLA-DMB(1), HLA-DOA(3), HLA-DOB(3), HLA-DQA2(3), HLA-DQB1(2), HLA-DRA(1), HLA-DRB1(2), HLA-E(1), HLA-F(4), HLA-G(2), ICAM1(6), ICAM2(3), ICAM3(3), ICOS(1), ICOSLG(1), ITGA4(13), ITGA6(4), ITGA8(22), ITGA9(3), ITGAL(7), ITGAM(8), ITGAV(6), ITGB1(16), ITGB2(4), ITGB7(1), ITGB8(5), JAM2(2), L1CAM(10), MAG(5), MPZ(2), MPZL1(3), NCAM1(4), NCAM2(13), NEGR1(7), NEO1(4), NFASC(6), NLGN1(19), NLGN2(6), NLGN3(3), NRCAM(14), NRXN1(30), NRXN2(10), NRXN3(20), OCLN(1), PDCD1(2), PTPRC(19), PTPRF(17), PTPRM(24), PVR(3), PVRL1(1), PVRL2(3), PVRL3(9), SDC1(2), SDC2(2), SDC3(2), SDC4(1), SELE(7), SELL(2), SELP(15), SELPLG(1), SIGLEC1(13), SPN(3), VCAM1(10), VCAN(32) 112239504 705 308 692 243 104 138 197 124 142 0 0.251 1.000 1.000 274 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 126 ARAF(2), BID(3), BRAF(10), CASP3(2), CD244(3), CD247(2), CD48(1), FAS(5), FASLG(1), FCGR3A(7), FYN(5), GZMB(2), HLA-A(24), HLA-B(26), HLA-C(5), HLA-E(1), HLA-G(2), HRAS(32), ICAM1(6), ICAM2(3), IFNA10(1), IFNA14(1), IFNA16(4), IFNA17(3), IFNA2(1), IFNA21(2), IFNA4(4), IFNA6(1), IFNA8(3), IFNAR1(3), IFNAR2(2), IFNG(2), IFNGR1(4), IFNGR2(5), ITGAL(7), ITGB2(4), KIR2DL3(1), KIR3DL1(4), KIR3DL2(9), KLRC1(1), KLRC2(1), KLRC3(3), KLRK1(1), KRAS(1), LAT(3), LCK(5), LCP2(2), MAP2K1(5), MAP2K2(6), MAPK1(9), MICB(3), NCR1(6), NCR2(3), NFAT5(13), NFATC1(9), NFATC2(15), NFATC3(6), NFATC4(3), NRAS(1), PAK1(3), PIK3CA(96), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PLCG1(8), PLCG2(9), PPP3CA(2), PPP3CB(1), PRF1(4), PRKCA(7), PRKCG(12), PTK2B(4), PTPN11(2), PTPN6(2), RAC1(15), RAC2(2), RAC3(3), RAF1(3), SH2D1A(6), SH2D1B(2), SH3BP2(4), SHC1(3), SHC2(5), SHC3(6), SHC4(4), SOS1(9), SOS2(11), SYK(8), TNFRSF10A(3), TNFRSF10B(1), TNFRSF10D(1), TNFSF10(1), ULBP1(1), ULBP2(1), VAV1(8), VAV2(4), VAV3(4), ZAP70(2) 86347259 622 308 510 145 103 145 154 111 109 0 2.05e-07 1.000 1.000 275 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 110 ACTN1(4), ACTN2(11), ACTN4(6), ARHGAP5(10), BCAR1(3), CDC42(3), CDH5(7), CLDN10(4), CLDN11(1), CLDN15(3), CLDN16(6), CLDN17(3), CLDN18(3), CLDN2(2), CLDN22(2), CLDN23(1), CLDN4(1), CLDN6(2), CLDN7(1), CLDN8(1), CLDN9(1), CTNNA1(8), CTNNA2(29), CTNNA3(13), CTNNB1(6), CTNND1(8), CXCL12(3), CXCR4(2), CYBB(3), ESAM(4), F11R(3), GNAI1(2), GNAI2(1), GNAI3(1), ICAM1(6), ITGA4(13), ITGAL(7), ITGAM(8), ITGB1(16), ITGB2(4), ITK(3), JAM2(2), MAPK11(3), MAPK12(3), MAPK13(3), MAPK14(2), MLLT4(13), MMP2(5), MMP9(1), MSN(3), MYL7(2), MYL9(4), NCF1(2), NCF2(6), NCF4(2), NOX1(6), NOX3(8), OCLN(1), PIK3CA(96), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PLCG1(8), PLCG2(9), PRKCA(7), PRKCG(12), PTK2(8), PTK2B(4), PTPN11(2), PXN(2), RAC1(15), RAC2(2), RAP1B(3), RAPGEF3(6), RAPGEF4(1), RASSF5(2), RHOA(10), RHOH(1), ROCK1(19), ROCK2(10), SIPA1(3), THY1(2), TXK(5), VASP(1), VAV1(8), VAV2(4), VAV3(4), VCAM1(10), VCL(6) 94614174 607 305 529 172 90 152 146 123 95 1 0.00219 1.000 1.000 276 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 85 ABL1(8), ABL2(10), AKT1(2), AKT2(3), AKT3(6), ARAF(2), BAD(1), BRAF(10), BTC(3), CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), CBL(3), CBLB(7), CBLC(1), CDKN1B(2), CRK(2), CRKL(3), EGF(9), EGFR(19), EIF4EBP1(1), ELK1(2), ERBB2(11), ERBB3(14), ERBB4(21), EREG(1), GAB1(5), GSK3B(3), HRAS(32), JUN(1), KRAS(1), MAP2K1(5), MAP2K2(6), MAP2K4(2), MAP2K7(2), MAPK1(9), MAPK10(4), MAPK8(4), MAPK9(4), MYC(6), NCK1(5), NCK2(7), NRAS(1), NRG1(1), NRG2(5), NRG3(17), NRG4(3), PAK1(3), PAK2(8), PAK3(4), PAK4(1), PAK6(5), PAK7(9), PIK3CA(96), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PLCG1(8), PLCG2(9), PRKCA(7), PRKCG(12), PTK2(8), RAF1(3), RPS6KB1(5), RPS6KB2(2), SHC1(3), SHC2(5), SHC3(6), SHC4(4), SOS1(9), SOS2(11), STAT5A(3), STAT5B(5) 78327720 567 304 470 140 76 147 164 116 63 1 7.78e-05 1.000 1.000 277 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 63 AKT1(2), AKT2(3), AKT3(6), BAD(1), BCL2L1(2), CDC42(3), CDKN1B(2), CDKN2A(114), CREB1(1), CREB5(8), EBP(1), ERBB4(21), F2RL2(2), GAB1(5), GADD45A(1), GSK3A(2), GSK3B(3), IGF1(1), IGFBP1(3), INPPL1(9), IRS1(4), IRS2(6), IRS4(16), MET(4), MYC(6), NOLC1(6), PAK1(3), PAK2(8), PAK3(4), PAK4(1), PAK6(5), PAK7(9), PARD3(15), PARD6A(1), PDK1(3), PIK3CA(96), PIK3CD(8), PPP1R13B(2), PREX1(15), PTEN(14), PTK2(8), PTPN1(3), RPS6KA1(10), RPS6KA2(6), RPS6KA3(4), RPS6KB1(5), SFN(7), SHC1(3), SLC2A4(3), SOS1(9), SOS2(11), TSC1(4), TSC2(8), YWHAB(2), YWHAE(2), YWHAG(1), YWHAH(2), YWHAQ(3), YWHAZ(2) 58818315 509 304 386 90 48 123 95 90 150 3 2.08e-11 1.000 1.000 278 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 92 ADCY1(21), ADCY2(29), ADCY3(8), ADCY4(8), ADCY5(10), ADCY6(6), ADCY7(5), ADCY8(28), ADCY9(9), ADRB1(3), CSNK1D(1), DRD1(2), DRD2(4), EGF(9), EGFR(19), GJA1(2), GJD2(2), GNA11(4), GNAI1(2), GNAI2(1), GNAI3(1), GNAS(12), GRM1(29), GRM5(12), GUCY1A2(10), GUCY1A3(9), GUCY1B3(7), GUCY2C(10), GUCY2D(9), GUCY2F(9), HRAS(32), HTR2A(5), HTR2B(2), HTR2C(3), ITPR1(16), ITPR2(25), ITPR3(10), KRAS(1), MAP2K1(5), MAP2K2(6), MAP2K5(3), MAP3K2(1), MAPK1(9), MAPK7(6), NPR1(4), NPR2(8), NRAS(1), PDGFB(1), PDGFC(3), PDGFD(6), PDGFRA(14), PDGFRB(8), PLCB1(21), PLCB2(7), PLCB3(8), PLCB4(17), PRKACA(4), PRKACB(3), PRKACG(3), PRKCA(7), PRKCG(12), PRKG1(8), PRKG2(2), PRKX(1), RAF1(3), SOS1(9), SOS2(11), TJP1(12), TUBA1B(5), TUBA3C(10), TUBA3D(3), TUBA3E(7), TUBA4A(1), TUBA8(2), TUBAL3(4), TUBB(3), TUBB1(3), TUBB2A(1), TUBB3(1), TUBB6(4), TUBB8(2) 100460063 624 303 588 179 121 135 190 109 68 1 0.000249 1.000 1.000 279 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADA(2), ADCY1(21), ADCY2(29), ADCY3(8), ADCY4(8), ADCY5(10), ADCY6(6), ADCY7(5), ADCY8(28), ADCY9(9), ADK(2), ADSL(5), ADSS(4), ADSSL1(6), AK1(1), AK2(1), AK5(12), AK7(2), ALLC(4), AMPD1(7), AMPD2(3), AMPD3(2), ATIC(5), CANT1(3), DCK(4), ENPP1(10), ENPP3(8), ENTPD1(4), ENTPD2(1), ENTPD3(2), ENTPD4(5), ENTPD5(3), ENTPD6(2), ENTPD8(2), FHIT(1), GART(4), GDA(7), GMPR(1), GMPR2(3), GMPS(7), GUCY1A2(10), GUCY1A3(9), GUCY1B3(7), GUCY2C(10), GUCY2D(9), GUCY2F(9), GUK1(1), HPRT1(2), IMPDH1(3), IMPDH2(1), ITPA(4), NME2(1), NME4(2), NME7(4), NPR1(4), NPR2(8), NT5C1A(2), NT5C1B(7), NT5C2(2), NT5E(1), NUDT2(1), NUDT5(2), NUDT9(1), PAPSS1(6), PAPSS2(6), PDE10A(20), PDE11A(3), PDE1A(6), PDE1C(14), PDE2A(4), PDE3B(4), PDE4A(5), PDE4B(7), PDE4C(4), PDE4D(7), PDE5A(9), PDE7A(4), PDE7B(1), PDE8A(3), PDE8B(12), PDE9A(3), PFAS(13), PKLR(3), PNPT1(6), POLA1(4), POLA2(2), POLD1(11), POLD2(1), POLD3(4), POLE(11), POLE2(1), POLR1A(10), POLR1B(4), POLR1C(2), POLR2A(11), POLR2B(10), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(3), POLR2G(4), POLR2H(1), POLR2I(1), POLR2J(2), POLR2L(2), POLR3A(9), POLR3B(4), POLR3G(1), POLR3GL(2), POLR3H(1), PPAT(3), PRIM1(3), PRIM2(1), PRPS1(3), PRPS1L1(5), PRPS2(2), PRUNE(2), RFC5(2), RRM1(1), RRM2(1), RRM2B(1), XDH(6) 124133963 621 300 618 204 111 131 188 102 89 0 0.170 1.000 1.000 280 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY1(21), ADCY2(29), ADCY3(8), ADCY4(8), ADCY5(10), ADCY6(6), ADCY7(5), ADCY8(28), ADCY9(9), ATF4(5), CACNA1C(23), CACNA1D(21), CACNA1F(11), CACNA1S(16), CALM1(1), CALM2(2), CALM3(2), CALML3(1), CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), CDC42(3), CGA(1), EGFR(19), ELK1(2), FSHB(2), GNA11(4), GNAS(12), GNRHR(2), HRAS(32), ITPR1(16), ITPR2(25), ITPR3(10), JUN(1), KRAS(1), LHB(2), MAP2K1(5), MAP2K2(6), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAP2K7(2), MAP3K1(6), MAP3K2(1), MAP3K3(3), MAP3K4(14), MAPK1(9), MAPK10(4), MAPK11(3), MAPK12(3), MAPK13(3), MAPK14(2), MAPK7(6), MAPK8(4), MAPK9(4), MMP14(4), MMP2(5), NRAS(1), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PLCB1(21), PLCB2(7), PLCB3(8), PLCB4(17), PLD1(15), PLD2(1), PRKACA(4), PRKACB(3), PRKACG(3), PRKCA(7), PRKCD(4), PRKX(1), PTK2B(4), RAF1(3), SOS1(9), SOS2(11) 96498983 576 299 540 181 120 127 170 93 66 0 0.00646 1.000 1.000 281 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 92 AKT1(2), AKT2(3), AKT3(6), BCL10(1), CARD11(12), CBL(3), CBLB(7), CBLC(1), CD247(2), CD28(3), CD3D(1), CD4(1), CD40LG(5), CD8A(2), CD8B(2), CDC42(3), CDK4(5), CHUK(6), CTLA4(2), FOS(6), FYN(5), GRAP2(2), HRAS(32), ICOS(1), IFNG(2), IKBKB(12), IL2(2), IL4(1), IL5(2), ITK(3), JUN(1), KRAS(1), LAT(3), LCK(5), LCP2(2), MALT1(3), MAP3K8(4), NCK1(5), NCK2(7), NFAT5(13), NFATC1(9), NFATC2(15), NFATC3(6), NFATC4(3), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(1), NFKBIE(1), NRAS(1), PAK1(3), PAK2(8), PAK3(4), PAK4(1), PAK6(5), PAK7(9), PDCD1(2), PDK1(3), PIK3CA(96), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PLCG1(8), PPP3CA(2), PPP3CB(1), PRKCQ(8), PTPN6(2), PTPRC(19), RASGRP1(8), RHOA(10), SOS1(9), SOS2(11), TEC(2), VAV1(8), VAV2(4), VAV3(4), ZAP70(2) 77308677 521 297 432 128 72 132 141 103 73 0 0.000145 1.000 1.000 282 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 73 CALM1(1), CALM2(2), CALM3(2), CALML3(1), CDIPT(1), CDS1(3), CDS2(3), DGKA(4), DGKB(12), DGKD(7), DGKE(5), DGKG(6), DGKH(4), DGKI(11), DGKQ(7), DGKZ(7), FN3K(3), IMPA1(2), IMPA2(4), INPP1(2), INPP4A(8), INPP4B(11), INPP5A(3), INPP5B(5), INPP5D(9), INPP5E(1), INPPL1(9), ITPK1(3), ITPKB(5), ITPR1(16), ITPR2(25), ITPR3(10), OCRL(4), PI4KA(7), PI4KB(2), PIK3C2A(6), PIK3C2B(10), PIK3C2G(13), PIK3C3(5), PIK3CA(96), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PIP4K2B(3), PIP4K2C(3), PIP5K1A(4), PIP5K1B(8), PIP5K1C(2), PLCB1(21), PLCB2(7), PLCB3(8), PLCB4(17), PLCD1(4), PLCD3(2), PLCD4(2), PLCE1(21), PLCG1(8), PLCG2(9), PLCZ1(7), PRKCA(7), PRKCG(12), PTEN(14), PTPMT1(2), SYNJ1(9), SYNJ2(9) 94528826 580 296 512 149 76 156 135 122 91 0 1.41e-05 1.000 1.000 283 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 75 ACP1(1), ACTB(5), ACTG1(3), ACTN1(4), ACTN2(11), ACTN4(6), ACVR1B(5), ACVR1C(8), BAIAP2(2), CDC42(3), CDH1(5), CREBBP(39), CSNK2A1(7), CSNK2A2(3), CSNK2B(2), CTNNA1(8), CTNNA2(29), CTNNA3(13), CTNNB1(6), CTNND1(8), EGFR(19), EP300(39), ERBB2(11), FARP2(3), FER(6), FGFR1(2), FYN(5), IGF1R(13), INSR(3), IQGAP1(11), LEF1(5), LMO7(8), MAP3K7(8), MAPK1(9), MET(4), MLLT4(13), NLK(1), PARD3(15), PTPN1(3), PTPN6(2), PTPRB(22), PTPRF(17), PTPRJ(7), PTPRM(24), PVRL1(1), PVRL2(3), PVRL3(9), PVRL4(3), RAC1(15), RAC2(2), RAC3(3), RHOA(10), SMAD2(4), SMAD3(4), SMAD4(14), SNAI2(1), SORBS1(7), SSX2IP(6), TCF7(2), TCF7L1(2), TCF7L2(1), TGFBR1(2), TGFBR2(25), TJP1(12), VCL(6), WAS(2), WASF1(3), WASF2(5), WASF3(5), WASL(2), YES1(2) 90985072 569 296 530 152 99 119 148 104 97 2 0.00320 1.000 1.000 284 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY1(21), ADCY2(29), ADCY3(8), ADCY4(8), ADCY5(10), ADCY6(6), ADCY7(5), ADCY8(28), ADCY9(9), AKAP1(8), AKAP10(5), AKAP11(8), AKAP12(13), AKAP2(13), AKAP3(8), AKAP4(11), AKAP5(3), AKAP6(27), AKAP7(4), AKAP8(4), AKAP9(30), ARHGEF1(9), CALM1(1), CALM2(2), CALM3(2), CHMP1B(2), GNA11(4), GNA12(1), GNA13(2), GNA14(3), GNA15(4), GNAI2(1), GNAI3(1), GNAL(4), GNAO1(1), GNAZ(7), GNB1(3), GNB2(4), GNB3(6), GNB5(2), GNG10(1), GNG12(1), GNG13(2), HRAS(32), ITPR1(16), KCNJ3(11), KRAS(1), NRAS(1), PALM2(2), PDE1A(6), PDE1B(4), PDE1C(14), PDE4A(5), PDE4B(7), PDE4C(4), PDE4D(7), PDE7A(4), PDE7B(1), PDE8A(3), PDE8B(12), PLCB3(8), PPP3CA(2), PRKACA(4), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PRKCA(7), PRKCD(4), PRKCE(3), PRKCG(12), PRKCH(4), PRKCI(3), PRKCQ(8), PRKCZ(3), PRKD1(15), PRKD3(9), RHOA(10), RRAS(2), SLC9A1(4), USP5(5) 88823249 570 294 540 153 114 128 162 93 73 0 0.000275 1.000 1.000 285 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 99 ADCY1(21), ADCY2(29), ADCY3(8), ADCY4(8), ADCY5(10), ADCY6(6), ADCY7(5), ADCY8(28), ADCY9(9), CALM1(1), CALM2(2), CALM3(2), CALML3(1), CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), CREB1(1), CREB3L1(4), CREB3L2(3), CREB3L3(9), CREB3L4(2), CREBBP(39), CTNNB1(6), DCT(4), DVL1(7), DVL2(1), DVL3(9), EDN1(1), EDNRB(7), EP300(39), FZD1(6), FZD10(5), FZD2(4), FZD3(2), FZD4(2), FZD5(1), FZD6(5), FZD7(1), FZD8(2), FZD9(2), GNAI1(2), GNAI2(1), GNAI3(1), GNAO1(1), GNAS(12), GSK3B(3), HRAS(32), KIT(11), KITLG(1), KRAS(1), LEF1(5), MAP2K1(5), MAP2K2(6), MAPK1(9), MC1R(2), MITF(6), NRAS(1), PLCB1(21), PLCB2(7), PLCB3(8), PLCB4(17), POMC(1), PRKACA(4), PRKACB(3), PRKACG(3), PRKCA(7), PRKCG(12), PRKX(1), RAF1(3), TCF7(2), TCF7L1(2), TCF7L2(1), TYR(8), TYRP1(4), WNT1(2), WNT10A(2), WNT10B(1), WNT11(2), WNT16(2), WNT2(3), WNT3(4), WNT3A(1), WNT4(2), WNT5A(3), WNT5B(1), WNT6(2), WNT7A(3), WNT7B(1), WNT8A(2), WNT8B(3), WNT9A(5), WNT9B(3) 83004478 548 294 506 151 122 100 159 93 72 2 5.09e-05 1.000 1.000 286 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 82 ACVR1(5), ACVR1B(5), ACVRL1(4), AKT1(2), AURKB(3), BMPR2(6), BUB1(6), CDIPT(1), CDKL1(1), CDKL2(1), CDS1(3), CDS2(3), CLK1(3), CLK2(11), CLK4(2), COL4A3BP(7), CSNK2A1(7), CSNK2A2(3), CSNK2B(2), DGKA(4), DGKB(12), DGKD(7), DGKE(5), DGKG(6), DGKH(4), DGKQ(7), DGKZ(7), IMPA1(2), INPP1(2), INPP4A(8), INPP4B(11), INPP5A(3), INPPL1(9), ITPKB(5), MAP3K10(6), MOS(7), NEK1(9), NEK3(1), OCRL(4), PAK4(1), PIK3C2A(6), PIK3C2B(10), PIK3C2G(13), PIK3CA(96), PIK3CB(7), PIK3CG(20), PLCB1(21), PLCB2(7), PLCB3(8), PLCB4(17), PLCD1(4), PLCG1(8), PLCG2(9), PLK3(6), PRKACA(4), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PRKCA(7), PRKCD(4), PRKCE(3), PRKCG(12), PRKCH(4), PRKCQ(8), PRKCZ(3), PRKD1(15), PRKG1(8), RAF1(3), RPS6KA1(10), RPS6KA2(6), RPS6KA3(4), RPS6KA4(3), RPS6KB1(5), STK11(7), TGFBR1(2), VRK1(1) 85727976 552 294 484 142 84 141 144 103 80 0 7.07e-05 1.000 1.000 287 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 98 AKT1(2), AKT2(3), AKT3(6), CASP8(61), CCL3(1), CD14(1), CD40(7), CD80(5), CD86(2), CHUK(6), CXCL10(2), CXCL9(3), FADD(4), FOS(6), IFNA10(1), IFNA14(1), IFNA16(4), IFNA17(3), IFNA2(1), IFNA21(2), IFNA4(4), IFNA6(1), IFNA8(3), IFNAR1(3), IFNAR2(2), IKBKB(12), IKBKE(5), IL12A(1), IL12B(4), IL1B(1), IL6(2), IRAK1(3), IRAK4(3), IRF3(2), IRF5(3), IRF7(3), JUN(1), LBP(8), LY96(2), MAP2K1(5), MAP2K2(6), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAP2K7(2), MAP3K7(8), MAP3K8(4), MAPK1(9), MAPK10(4), MAPK11(3), MAPK12(3), MAPK13(3), MAPK14(2), MAPK8(4), MAPK9(4), NFKB1(5), NFKB2(5), NFKBIA(1), PIK3CA(96), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), RAC1(15), RELA(2), RIPK1(2), SPP1(2), STAT1(7), TBK1(3), TICAM1(5), TIRAP(1), TLR1(3), TLR2(3), TLR3(2), TLR4(16), TLR5(4), TLR6(4), TLR7(8), TLR8(7), TLR9(3), TOLLIP(2), TRAF3(6), TRAF6(3) 68325840 519 292 429 118 73 143 119 94 88 2 9.57e-08 1.000 1.000 288 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 162 ADORA1(4), ADORA2A(2), ADORA2B(1), ADORA3(3), ADRA1A(5), ADRA1B(3), ADRA1D(3), ADRA2C(3), ADRB1(3), ADRB3(2), AGTR1(14), AGTR2(2), AVPR1A(9), AVPR1B(7), AVPR2(2), BDKRB1(3), BDKRB2(3), BRS3(3), C3AR1(5), CCKAR(5), CCKBR(5), CCR1(1), CCR10(2), CCR2(4), CCR3(6), CCR4(4), CCR6(2), CCR7(2), CCR9(2), CCRL2(3), CHML(8), CHRM2(5), CHRM3(9), CHRM4(2), CHRM5(3), CMKLR1(3), CNR1(4), CX3CR1(1), CXCR3(1), CXCR4(2), DRD1(2), DRD2(4), DRD3(6), DRD4(1), DRD5(8), EDNRA(2), EDNRB(7), F2R(4), F2RL1(1), F2RL2(2), F2RL3(3), FPR1(7), FSHR(12), GALR1(4), GALR2(4), GALR3(2), GALT(2), GHSR(3), GNB2L1(1), GPR17(3), GPR173(1), GPR174(4), GPR27(2), GPR3(2), GPR35(2), GPR37(10), GPR37L1(5), GPR4(1), GPR50(6), GPR6(5), GPR63(6), GPR83(1), GRPR(1), HCRTR1(3), HCRTR2(7), HRH1(1), HRH2(3), HRH3(3), HTR1A(9), HTR1B(7), HTR1D(2), HTR1E(8), HTR1F(4), HTR2A(5), HTR2B(2), HTR2C(3), HTR4(2), HTR5A(8), HTR6(6), HTR7(7), LHCGR(9), LTB4R(3), MAS1(2), MC1R(2), MC3R(4), MC4R(4), MC5R(9), MLNR(4), MTNR1A(3), MTNR1B(3), NMBR(3), NMUR1(5), NMUR2(1), NPY1R(6), NPY2R(5), NPY5R(8), NTSR1(3), NTSR2(6), OPN1SW(1), OPN3(3), OPRD1(2), OPRK1(7), OPRL1(6), OPRM1(4), OR10A5(4), OR11A1(3), OR12D3(3), OR1C1(8), OR1F1(2), OR1Q1(2), OR2H1(4), OR5V1(6), OR7A5(7), OR8B8(1), OXTR(2), P2RY1(5), P2RY10(5), P2RY11(3), P2RY13(3), P2RY14(1), P2RY2(3), P2RY6(2), PTGDR(3), PTGER2(5), PTGER4(6), PTGFR(2), PTGIR(2), RGR(4), RHO(3), RRH(3), SSTR1(8), SSTR2(3), SSTR3(6), SSTR4(7), SUCNR1(1), TBXA2R(1), TRHR(7) 92553685 583 288 581 229 115 124 189 96 59 0 0.0732 1.000 1.000 289 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(4), ACTA2(3), ACTN2(11), ACTN4(6), DES(3), DMD(53), MYBPC1(12), MYBPC2(8), MYBPC3(5), MYH3(14), MYH6(20), MYH7(16), MYH8(26), MYL1(1), MYL4(2), MYL9(4), MYOM1(15), NEB(41), TMOD1(2), TNNC2(1), TNNI2(4), TNNI3(1), TNNT1(2), TNNT2(4), TNNT3(2), TPM1(2), TPM2(2), TPM4(1), TTN(387), VIM(4) 103717356 656 288 651 187 90 159 237 98 67 5 0.180 1.000 1.000 290 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ADCY1(21), ADCY8(28), ARAF(2), ATF4(5), BRAF(10), CACNA1C(23), CALM1(1), CALM2(2), CALM3(2), CALML3(1), CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), CREBBP(39), EP300(39), GRIA1(17), GRIA2(16), GRIN1(4), GRIN2A(21), GRIN2B(23), GRIN2C(7), GRIN2D(6), GRM1(29), GRM5(12), HRAS(32), ITPR1(16), ITPR2(25), ITPR3(10), KRAS(1), MAP2K1(5), MAP2K2(6), MAPK1(9), NRAS(1), PLCB1(21), PLCB2(7), PLCB3(8), PLCB4(17), PPP1CA(1), PPP1R12A(5), PPP1R1A(1), PPP3CA(2), PPP3CB(1), PRKACA(4), PRKACB(3), PRKACG(3), PRKCA(7), PRKCG(12), PRKX(1), RAF1(3), RAP1B(3), RAPGEF3(6), RPS6KA1(10), RPS6KA2(6), RPS6KA3(4), RPS6KA6(8) 75495212 557 284 515 165 99 123 159 103 72 1 0.00192 1.000 1.000 291 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADA(2), ADCY1(21), ADCY2(29), ADCY3(8), ADCY4(8), ADCY5(10), ADCY6(6), ADCY7(5), ADCY8(28), ADK(2), ADSL(5), ADSS(4), AK1(1), AK2(1), AK5(12), ALLC(4), AMPD1(7), AMPD2(3), AMPD3(2), ATIC(5), ATP1B1(2), ATP5A1(1), ATP5B(2), ATP5C1(1), ATP5F1(1), ATP5G1(1), ATP5G2(2), ATP5G3(1), ATP5H(1), CANT1(3), DCK(4), ENPP1(10), ENPP3(8), ENTPD1(4), ENTPD2(1), FHIT(1), GART(4), GDA(7), GMPS(7), GUCY1A2(10), GUCY1A3(9), GUCY1B3(7), GUCY2C(10), GUCY2D(9), GUCY2F(9), GUK1(1), HPRT1(2), IMPDH1(3), IMPDH2(1), ITPA(4), NME2(1), NPR1(4), NPR2(8), NT5E(1), NUDT2(1), PAPSS1(6), PAPSS2(6), PDE1A(6), PDE4A(5), PDE4B(7), PDE4C(4), PDE4D(7), PDE5A(9), PDE6B(2), PDE6C(3), PDE7B(1), PDE8A(3), PDE9A(3), PFAS(13), PKLR(3), POLB(1), POLD1(11), POLD2(1), POLE(11), POLG(8), POLL(6), POLQ(22), POLR1B(4), POLR2A(11), POLR2B(10), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(3), POLR2G(4), POLR2H(1), POLR2I(1), POLR2J(2), POLR2L(2), POLRMT(6), PPAT(3), PRPS1(3), PRPS1L1(5), PRPS2(2), PRUNE(2), RRM1(1), RRM2(1) 97524512 506 272 503 159 87 107 162 74 76 0 0.0711 1.000 1.000 292 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 74 AKT1(2), AKT2(3), AKT3(6), BTK(8), FCER1A(4), FYN(5), GAB2(4), HRAS(32), IL13(1), IL3(1), IL4(1), IL5(2), INPP5D(9), KRAS(1), LAT(3), LCP2(2), LYN(8), MAP2K1(5), MAP2K2(6), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAP2K7(2), MAPK1(9), MAPK10(4), MAPK11(3), MAPK12(3), MAPK13(3), MAPK14(2), MAPK8(4), MAPK9(4), MS4A2(5), NRAS(1), PDK1(3), PIK3CA(96), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PLCG1(8), PLCG2(9), PRKCA(7), PRKCD(4), PRKCE(3), RAC1(15), RAC2(2), RAC3(3), RAF1(3), SOS1(9), SOS2(11), SYK(8), VAV1(8), VAV2(4), VAV3(4) 54837372 430 263 330 97 71 112 111 82 53 1 5.28e-06 1.000 1.000 293 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 88 ACVR1(5), ACVR1B(5), ACVR1C(8), ACVR2A(1), ACVR2B(1), ACVRL1(4), AMHR2(1), BMP2(5), BMP4(4), BMP5(6), BMP6(7), BMP7(3), BMP8A(1), BMP8B(4), BMPR1B(4), BMPR2(6), CHRD(12), CREBBP(39), CUL1(11), DCN(4), E2F4(2), E2F5(6), EP300(39), GDF5(4), GDF6(6), ID1(1), ID2(1), ID3(1), IFNG(2), INHBA(4), INHBB(4), INHBC(3), INHBE(1), LEFTY1(2), LEFTY2(1), LTBP1(22), MAPK1(9), MYC(6), NOG(2), PITX2(2), PPP2CB(3), PPP2R1A(3), PPP2R1B(4), PPP2R2A(2), PPP2R2B(4), PPP2R2C(1), RBL1(11), RBL2(6), RBX1(3), RHOA(10), ROCK1(19), ROCK2(10), RPS6KB1(5), RPS6KB2(2), SKP1(1), SMAD1(3), SMAD2(4), SMAD3(4), SMAD4(14), SMAD5(1), SMAD6(1), SMAD9(4), SMURF1(3), SMURF2(6), SP1(3), TFDP1(2), TGFB1(1), TGFB2(3), TGFB3(1), TGFBR1(2), TGFBR2(25), THBS1(8), THBS2(11), THBS3(4), THBS4(7), ZFYVE16(10), ZFYVE9(8) 75337553 458 260 429 100 57 100 122 84 94 1 7.63e-06 1.000 1.000 294 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 62 AKT1(2), AKT2(3), AKT3(6), BCL10(1), BLNK(5), BTK(8), CARD11(12), CD19(4), CD22(3), CD72(1), CD79A(1), CHUK(6), CR2(8), FCGR2B(1), FOS(6), GSK3B(3), HRAS(32), IKBKB(12), INPP5D(9), JUN(1), KRAS(1), LILRB3(5), LYN(8), MALT1(3), NFAT5(13), NFATC1(9), NFATC2(15), NFATC3(6), NFATC4(3), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(1), NFKBIE(1), NRAS(1), PIK3CA(96), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PLCG2(9), PPP3CA(2), PPP3CB(1), PTPN6(2), RAC1(15), RAC2(2), RAC3(3), RASGRP3(8), SYK(8), VAV1(8), VAV2(4), VAV3(4) 56724681 429 260 336 96 70 120 101 85 52 1 8.60e-07 1.000 1.000 295 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 ARAF(2), BRAF(10), CACNA1A(14), CRH(1), CRHR1(3), GNA11(4), GNA12(1), GNA13(2), GNAI1(2), GNAI2(1), GNAI3(1), GNAO1(1), GNAS(12), GNAZ(7), GRIA1(17), GRIA2(16), GRIA3(8), GRID2(21), GRM1(29), GRM5(12), GUCY1A2(10), GUCY1A3(9), GUCY1B3(7), GUCY2C(10), GUCY2D(9), GUCY2F(9), HRAS(32), IGF1(1), IGF1R(13), ITPR1(16), ITPR2(25), ITPR3(10), KRAS(1), LYN(8), MAP2K1(5), MAP2K2(6), MAPK1(9), NOS1(9), NOS3(4), NPR1(4), NPR2(8), NRAS(1), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PLCB1(21), PLCB2(7), PLCB3(8), PLCB4(17), PPP2CB(3), PPP2R1A(3), PPP2R1B(4), PPP2R2A(2), PPP2R2B(4), PPP2R2C(1), PRKCA(7), PRKCG(12), PRKG1(8), PRKG2(2), RAF1(3), RYR1(34) 83587934 523 260 491 153 101 104 163 93 62 0 0.00893 1.000 1.000 296 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 69 AKT1(2), AKT2(3), AKT3(6), BAD(1), CASP9(1), CDC42(3), HRAS(32), KDR(13), KRAS(1), MAP2K1(5), MAP2K2(6), MAPK1(9), MAPK11(3), MAPK12(3), MAPK13(3), MAPK14(2), MAPKAPK3(4), NFAT5(13), NFATC1(9), NFATC2(15), NFATC3(6), NFATC4(3), NOS3(4), NRAS(1), PIK3CA(96), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PLCG1(8), PLCG2(9), PPP3CA(2), PPP3CB(1), PRKCA(7), PRKCG(12), PTGS2(4), PTK2(8), PXN(2), RAC1(15), RAC2(2), RAC3(3), RAF1(3), SHC2(5), SPHK2(3) 54870143 411 251 311 98 77 113 98 77 46 0 5.38e-06 1.000 1.000 297 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(16), ABCA10(13), ABCA12(19), ABCA13(39), ABCA2(17), ABCA3(10), ABCA4(15), ABCA5(6), ABCA6(11), ABCA7(9), ABCA8(10), ABCA9(14), ABCB1(20), ABCB11(9), ABCB4(13), ABCB5(11), ABCB6(6), ABCB7(5), ABCB8(6), ABCB9(3), ABCC1(5), ABCC10(9), ABCC11(9), ABCC12(10), ABCC2(9), ABCC3(4), ABCC4(5), ABCC5(8), ABCC6(3), ABCC8(20), ABCC9(29), ABCD1(4), ABCD2(5), ABCD3(4), ABCD4(6), ABCG1(3), ABCG2(4), ABCG4(9), ABCG8(13), CFTR(14), TAP1(6), TAP2(3) 89789433 434 246 432 141 65 90 131 70 78 0 0.0767 1.000 1.000 298 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(5), AMY2A(3), AMY2B(9), ASCC3(12), ATP13A2(2), DDX18(3), DDX19A(2), DDX23(3), DDX4(4), DDX41(5), DDX47(2), DDX50(1), DDX51(3), DDX52(6), DDX54(5), DDX55(3), DDX56(4), DHX58(2), ENPP1(10), ENPP3(8), ENTPD7(4), EP400(19), ERCC2(5), ERCC3(5), G6PC(2), G6PC2(7), GAA(3), GANC(6), GBA(3), GCK(4), GPI(3), GUSB(5), GYS1(6), GYS2(7), HK1(4), HK2(5), HK3(8), IFIH1(6), MGAM(32), MOV10L1(5), NUDT5(2), NUDT8(1), PGM1(5), PGM3(1), PYGB(5), PYGL(9), PYGM(8), RAD54B(6), RAD54L(5), RUVBL2(2), SETX(12), SI(61), SKIV2L2(4), SMARCA2(13), SMARCA5(2), UGDH(4), UGP2(2), UGT1A1(4), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A9(1), UGT2A1(6), UGT2A3(7), UGT2B10(11), UGT2B11(9), UGT2B15(4), UGT2B17(5), UGT2B28(6), UGT2B4(13), UGT2B7(7), UXS1(2) 94008768 461 244 459 145 55 90 152 94 69 1 0.421 1.000 1.000 299 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 47 FN3K(3), IMPA1(2), IMPA2(4), INPP1(2), INPP4A(8), INPP4B(11), INPP5A(3), INPP5B(5), INPP5E(1), INPPL1(9), IPMK(2), ISYNA1(4), ITPK1(3), ITPKB(5), MINPP1(4), MIOX(4), OCRL(4), PI4KA(7), PI4KB(2), PIK3C3(5), PIK3CA(96), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIP4K2B(3), PIP4K2C(3), PIP5K1A(4), PIP5K1B(8), PIP5K1C(2), PLCB1(21), PLCB2(7), PLCB3(8), PLCB4(17), PLCD1(4), PLCD3(2), PLCD4(2), PLCE1(21), PLCG1(8), PLCG2(9), PLCZ1(7), PTEN(14), PTPMT1(2), SYNJ1(9), SYNJ2(9) 56518984 379 242 313 94 56 106 87 80 50 0 2.65e-05 1.000 1.000 300 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 92 ACTB(5), BAD(1), BCL2(1), CABIN1(15), CALM1(1), CALM2(2), CALM3(2), CAMK2B(3), CD69(1), CEBPB(1), CNR1(4), CREBBP(39), CSNK2A1(7), CSNK2B(2), CTLA4(2), EGR2(5), EP300(39), FCER1A(4), FCGR3A(7), FKBP1B(1), FOS(6), FOSL1(3), GATA3(9), GSK3A(2), GSK3B(3), HRAS(32), ICOS(1), IFNG(2), IL13(1), IL1B(1), IL2(2), IL2RA(2), IL3(1), IL4(1), IL6(2), ITK(3), JUNB(2), KPNA5(2), MAP2K7(2), MAPK14(2), MAPK8(4), MAPK9(4), MEF2A(3), MEF2B(5), MEF2D(1), MYF5(6), NCK2(7), NFAT5(13), NFATC1(9), NFATC2(15), NFATC3(6), NFATC4(3), NFKB2(5), NFKBIB(1), NFKBIE(1), NPPB(2), NUP214(12), OPRD1(2), P2RX7(1), PAK1(3), PIN1(1), PPP3CB(1), PTPRC(19), RELA(2), RPL13A(2), SFN(7), SLA(1), SP1(3), SP3(3), TGFB1(1), TRAF2(2), TRPV6(7), VAV1(8), VAV2(4), VAV3(4), XPO5(4) 69365760 393 241 362 114 57 75 121 75 64 1 0.0400 1.000 1.000 301 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(2), AKT3(6), BCAR1(3), CAPN1(3), CAPN10(4), CAPN11(2), CAPN2(6), CAPN3(5), CAPN5(2), CAPN6(10), CAPN7(2), CAPN9(4), CAPNS1(2), CAV1(1), CDC42(3), CRK(2), CSK(1), DOCK1(15), FYN(5), GIT2(3), ILK(4), ITGA10(9), ITGA11(10), ITGA2(7), ITGA2B(6), ITGA3(5), ITGA4(13), ITGA5(4), ITGA6(4), ITGA7(8), ITGA8(22), ITGA9(3), ITGAD(7), ITGAE(4), ITGAL(7), ITGAM(8), ITGAV(6), ITGAX(7), ITGB1(16), ITGB2(4), ITGB3(6), ITGB4(8), ITGB5(1), ITGB6(6), ITGB7(1), ITGB8(5), MAP2K1(5), MAP2K2(6), MAP2K3(4), MAP2K6(1), MAPK10(4), MAPK12(3), MAPK4(8), MAPK6(3), MAPK7(6), MYLK2(5), PAK1(3), PAK2(8), PAK3(4), PAK4(1), PAK6(5), PDPK1(4), PIK3R2(5), PTK2(8), PXN(2), RAC1(15), RAC2(2), RAC3(3), RAP1B(3), RAPGEF1(5), RHO(3), ROCK1(19), ROCK2(10), SDCCAG8(7), SEPP1(1), SHC1(3), SHC3(6), SORBS1(7), SOS1(9), TLN1(24), TNS1(8), VASP(1), VAV2(4), VAV3(4), VCL(6), ZYX(2) 101861619 489 241 477 155 85 106 144 74 80 0 0.0530 1.000 1.000 302 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 44 ACTR2(1), AKT1(2), AKT2(3), AKT3(6), ANGPTL2(3), ARHGAP1(4), ARHGAP4(9), ARHGEF11(4), BTK(8), CDC42(3), CFL1(2), GDI1(4), GDI2(5), INPPL1(9), ITPR1(16), ITPR2(25), ITPR3(10), LIMK1(5), MYLK(8), MYLK2(5), PAK1(3), PAK2(8), PAK3(4), PAK4(1), PAK6(5), PAK7(9), PDK1(3), PIK3CA(96), PIK3CD(8), PIK3CG(20), PIK3R1(10), PITX2(2), PPP1R13B(2), PTEN(14), RACGAP1(5), RHO(3), ROCK1(19), ROCK2(10), SAG(1), WASF1(3), WASL(2) 53221706 360 232 297 102 44 121 72 76 46 1 0.00274 1.000 1.000 303 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 28 BRAF(10), CPEB1(6), EGFR(19), ERBB2(11), ERBB4(21), ETS1(4), ETS2(7), ETV6(6), ETV7(4), FMN2(41), KRAS(1), MAP2K1(5), MAPK1(9), NOTCH1(95), NOTCH2(21), NOTCH3(23), NOTCH4(8), PIWIL1(11), PIWIL2(9), PIWIL3(7), PIWIL4(3), RAF1(3), SOS1(9), SOS2(11), SPIRE1(5), SPIRE2(1) 39865975 350 230 336 86 55 63 95 50 86 1 0.0289 1.000 1.000 304 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 ADAM17(5), APH1A(4), CREBBP(39), CTBP1(2), CTBP2(3), DLL1(5), DLL3(2), DLL4(2), DTX1(4), DTX2(1), DTX3(5), DTX3L(2), DTX4(5), DVL1(7), DVL2(1), DVL3(9), EP300(39), HDAC1(1), HDAC2(3), JAG1(7), JAG2(8), LFNG(2), MAML1(6), MAML2(6), MAML3(2), MFNG(2), NCOR2(24), NCSTN(2), NOTCH1(95), NOTCH2(21), NOTCH3(23), NOTCH4(8), NUMB(3), NUMBL(3), PSEN2(1), PTCRA(3), RBPJ(8), RBPJL(4), RFNG(3), SNW1(3) 52922862 373 229 362 106 66 76 80 49 100 2 0.0193 1.000 1.000 305 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 85 ATF2(1), BRAF(10), CHUK(6), CREB1(1), DAXX(5), ELK1(2), FOS(6), HRAS(32), IKBKB(12), JUN(1), MAP2K1(5), MAP2K2(6), MAP2K3(4), MAP2K4(2), MAP2K5(3), MAP2K6(1), MAP2K7(2), MAP3K1(6), MAP3K10(6), MAP3K11(2), MAP3K12(8), MAP3K13(15), MAP3K2(1), MAP3K3(3), MAP3K4(14), MAP3K5(6), MAP3K6(6), MAP3K7(8), MAP3K8(4), MAP3K9(9), MAP4K1(4), MAP4K2(2), MAP4K3(7), MAP4K4(4), MAP4K5(2), MAPK1(9), MAPK10(4), MAPK11(3), MAPK12(3), MAPK13(3), MAPK14(2), MAPK4(8), MAPK6(3), MAPK7(6), MAPK8(4), MAPK9(4), MAPKAPK3(4), MAPKAPK5(2), MAX(1), MEF2A(3), MEF2B(5), MEF2C(15), MEF2D(1), MKNK1(1), MKNK2(2), MYC(6), NFKB1(5), NFKBIA(1), PAK1(3), PAK2(8), RAC1(15), RAF1(3), RELA(2), RIPK1(2), RPS6KA1(10), RPS6KA2(6), RPS6KA3(4), RPS6KA4(3), RPS6KA5(5), RPS6KB1(5), RPS6KB2(2), SHC1(3), SP1(3), STAT1(7), TGFB1(1), TGFB2(3), TGFB3(1), TGFBR1(2), TRADD(1), TRAF2(2) 72623910 392 226 350 107 77 78 129 57 51 0 0.0195 1.000 1.000 306 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT1(2), AKT2(3), AKT3(6), BAD(1), BCL2(1), BCR(2), BLNK(5), BTK(8), CD19(4), CD22(3), CR2(8), CSK(1), DAG1(5), FLOT1(2), FLOT2(4), GSK3A(2), GSK3B(3), INPP5D(9), ITPR1(16), ITPR2(25), ITPR3(10), LYN(8), MAP4K1(4), MAPK1(9), NFATC1(9), NFATC2(15), NR0B2(1), PDK1(3), PIK3CA(96), PIK3CD(8), PIK3R1(10), PLCG2(9), PPP1R13B(2), PPP3CA(2), PPP3CB(1), PTPRC(19), RAF1(3), SHC1(3), SOS1(9), SOS2(11), SYK(8), VAV1(8) 56212303 358 222 289 95 52 114 62 85 44 1 0.000358 1.000 1.000 307 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 67 A2M(7), BDKRB1(3), BDKRB2(3), C1QA(3), C1QC(1), C1R(4), C1S(6), C2(6), C3(16), C3AR1(5), C4BPA(5), C4BPB(2), C5(11), C5AR1(2), C6(25), C7(12), C8A(8), C8B(9), C8G(1), C9(15), CD46(2), CD59(1), CFB(4), CFH(19), CFI(5), CPB2(4), CR1(10), CR2(8), F10(4), F11(2), F12(2), F13A1(8), F13B(13), F2(3), F2R(4), F3(2), F5(20), F7(3), F8(8), F9(9), FGA(10), FGB(4), FGG(6), KLKB1(7), KNG1(4), MASP1(7), MASP2(5), MBL2(2), PLAT(3), PLG(13), PROC(2), PROS1(9), SERPINA1(5), SERPINA5(9), SERPINC1(4), SERPIND1(4), SERPINE1(8), SERPING1(5), TFPI(2), THBD(2), VWF(19) 68851679 405 215 402 135 48 103 116 72 65 1 0.380 1.000 1.000 308 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 108 A4GNT(6), ALG1(4), ALG10(7), ALG10B(3), ALG11(3), ALG12(5), ALG13(4), ALG2(2), ALG3(1), ALG6(4), ALG8(1), B3GNT1(3), B3GNT2(1), B3GNT6(2), B3GNT7(3), B4GALT1(1), B4GALT2(5), B4GALT3(1), B4GALT4(2), B4GALT5(3), B4GALT7(2), C1GALT1(4), C1GALT1C1(3), CHPF(7), CHST1(4), CHST11(4), CHST12(5), CHST13(5), CHST14(2), CHST2(5), CHST4(4), CHST6(8), CHST7(2), CHSY1(3), DDOST(1), DPAGT1(1), EXT1(3), EXT2(5), EXTL1(3), EXTL2(3), EXTL3(2), FUT8(2), GALNT1(2), GALNT10(5), GALNT11(4), GALNT12(4), GALNT13(10), GALNT14(6), GALNT2(7), GALNT3(6), GALNT4(3), GALNT5(5), GALNT6(4), GALNT7(3), GALNT8(6), GALNTL5(5), GANAB(3), GCNT1(1), GCNT3(1), GCNT4(3), HS2ST1(5), HS3ST2(2), HS3ST3A1(3), HS3ST3B1(1), HS3ST5(6), HS6ST1(3), HS6ST2(1), HS6ST3(1), MAN1A1(2), MAN1A2(1), MAN1B1(4), MAN1C1(3), MAN2A1(4), MGAT1(4), MGAT2(2), MGAT3(5), MGAT4A(1), MGAT4B(3), MGAT5(4), MGAT5B(5), NDST1(1), NDST2(2), NDST3(7), NDST4(15), OGT(4), RPN1(2), RPN2(6), ST3GAL1(2), ST3GAL2(1), ST3GAL3(4), ST3GAL4(1), ST6GAL1(3), ST6GALNAC1(4), STT3B(2), UST(3), WBSCR17(9), XYLT1(10), XYLT2(3) 84055408 356 214 356 140 72 71 115 50 47 1 0.799 1.000 1.000 309 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 44 AKT1(2), AKT2(3), AKT3(6), BRAF(10), DDIT4(1), EIF4B(7), EIF4EBP1(1), FIGF(1), HIF1A(3), IGF1(1), MAPK1(9), PDPK1(4), PIK3CA(96), PIK3CB(7), PIK3CD(8), PIK3CG(20), PIK3R1(10), PIK3R2(5), PIK3R3(5), PIK3R5(11), PRKAA1(4), PRKAA2(4), RHEB(1), RICTOR(9), RPS6KA1(10), RPS6KA2(6), RPS6KA3(4), RPS6KA6(8), RPS6KB1(5), RPS6KB2(2), STK11(7), TSC1(4), TSC2(8), ULK1(8), ULK2(2), VEGFB(1), VEGFC(6) 40431581 299 209 228 55 43 98 56 61 41 0 2.65e-07 1.000 1.000 310 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 ASH1L(20), ASH2L(3), CARM1(5), CTCFL(4), DOT1L(9), EED(3), EHMT1(7), EHMT2(11), EZH1(5), EZH2(5), FBXO11(7), HCFC1(8), HSF4(1), JMJD4(2), JMJD6(2), KDM6A(17), MEN1(3), NSD1(73), OGT(4), PAXIP1(5), PPP1CA(1), PRDM2(14), PRDM7(3), PRDM9(37), PRMT1(2), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(4), RBBP5(2), SATB1(6), SETD1A(11), SETD2(12), SETD7(4), SETD8(1), SETDB1(10), SETDB2(2), SETMAR(2), SMYD3(2), STK38(3), SUV39H1(4), SUV39H2(2), SUV420H1(8), SUV420H2(4), SUZ12(2), WHSC1(9), WHSC1L1(6) 90336613 353 208 347 82 45 60 97 55 90 6 0.0144 1.000 1.000 311 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 AKT1(2), APC(27), AR(6), ASAH1(1), BRAF(10), CCL15(1), CCL16(1), DAG1(5), EGFR(19), GNA11(4), GNA15(4), GNAI1(2), ITPKB(5), ITPR1(16), ITPR2(25), ITPR3(10), KCNJ3(11), KCNJ5(3), KCNJ9(1), MAPK1(9), MAPK10(4), MAPK14(2), PHKA2(9), PIK3CA(96), PIK3CD(8), PIK3R1(10), PITX2(2), PTX3(4), RAF1(3) 40448312 300 207 230 64 39 100 58 69 34 0 3.12e-06 1.000 1.000 312 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 AKT1(2), AKT2(3), AKT3(6), BAD(1), BCR(2), BLNK(5), BTK(8), CD19(4), CSK(1), DAG1(5), EPHB2(3), ITPKB(5), LYN(8), MAP2K1(5), MAP2K2(6), MAPK1(9), NFAT5(13), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(1), NFKBIE(1), NFKBIL1(1), PI3(2), PIK3CA(96), PIK3CD(8), PIK3R1(10), PLCG2(9), PPP1R13B(2), RAF1(3), SERPINA4(7), SHC1(3), SOS1(9), SOS2(11), SYK(8), VAV1(8) 40209608 276 202 208 57 43 87 51 58 36 1 4.16e-06 1.000 1.000 313 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 70 ACACB(20), ACSL1(3), ACSL3(3), ACSL4(6), ACSL5(5), ACSL6(3), ADIPOQ(3), ADIPOR1(3), ADIPOR2(3), AGRP(1), AKT1(2), AKT2(3), AKT3(6), CAMKK1(1), CAMKK2(6), CD36(2), CHUK(6), CPT1A(6), CPT1B(4), CPT1C(8), CPT2(7), G6PC(2), G6PC2(7), IKBKB(12), IRS1(4), IRS2(6), IRS4(16), JAK1(11), JAK2(5), JAK3(6), LEP(1), LEPR(20), MAPK10(4), MAPK8(4), MAPK9(4), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(1), NFKBIE(1), NPY(5), PCK1(1), PCK2(4), POMC(1), PPARA(2), PPARGC1A(6), PRKAA1(4), PRKAA2(4), PRKAB1(4), PRKAB2(2), PRKAG2(2), PRKAG3(3), PRKCQ(8), PTPN11(2), RELA(2), RXRA(5), RXRB(3), RXRG(7), SLC2A1(4), SLC2A4(3), SOCS3(1), STAT3(6), STK11(7), TNFRSF1A(1), TNFRSF1B(2), TRADD(1), TRAF2(2), TYK2(8) 63166369 316 190 316 101 54 62 93 55 51 1 0.120 1.000 1.000 314 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 ACTG1(3), APAF1(12), ARHGDIB(1), BAG4(6), BCL2(1), BID(3), BIRC2(2), BIRC3(2), CASP2(3), CASP3(2), CASP6(5), CASP7(3), CASP8(61), CASP9(1), CFLAR(2), CHUK(6), CRADD(1), DAXX(5), FADD(4), GSN(5), LMNA(1), LMNB1(1), LMNB2(8), MAP2K7(2), MAP3K1(6), MAP3K5(6), MAPK8(4), MDM2(2), NFKB1(5), NFKBIA(1), NUMA1(17), PAK2(8), PRKCD(4), PRKDC(28), PSEN2(1), PTK2(8), RASA1(17), RB1(18), RELA(2), RIPK1(2), SPTAN1(24), TNFRSF1A(1), TNFRSF1B(2), TRADD(1), TRAF2(2) 52736295 299 189 285 73 34 55 73 45 89 3 0.0126 1.000 1.000 315 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR1(14), AGTR2(2), ATP8A1(17), AVPR1A(9), AVPR1B(7), AVPR2(2), BDKRB1(3), BDKRB2(3), BRS3(3), C3AR1(5), CCKAR(5), CCKBR(5), CCR1(1), CCR10(2), CCR2(4), CCR3(6), CCR4(4), CCR6(2), CCR7(2), CX3CR1(1), CXCR3(1), CXCR4(2), EDNRA(2), EDNRB(7), FPR1(7), FSHR(12), GALR1(4), GALR2(4), GALR3(2), GALT(2), GHSR(3), GNB2L1(1), GNRHR(2), GRPR(1), LHCGR(9), MC1R(2), MC2R(7), MC3R(4), MC4R(4), MC5R(9), NMBR(3), NPY1R(6), NPY2R(5), NPY5R(8), NTSR1(3), NTSR2(6), OPRD1(2), OPRK1(7), OPRL1(6), OPRM1(4), OXTR(2), SSTR1(8), SSTR2(3), SSTR3(6), SSTR4(7), TACR1(3), TACR2(4), TACR3(6), TRHR(7), TSHR(4) 39853918 282 185 282 98 52 67 85 43 35 0 0.0260 1.000 1.000 316 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 ACTR2(1), AKT1(2), ANGPTL2(3), DAG1(5), DGKA(4), ETFA(3), GCA(2), ITGA9(3), ITPKB(5), ITPR1(16), ITPR2(25), ITPR3(10), MAP2K1(5), MAPK1(9), NR1I3(1), PAK1(3), PDE3A(18), PDE3B(4), PI3(2), PIK3C2G(13), PIK3CA(96), PIK3CD(8), PIK3R1(10), PSME1(1), RIPK3(1), SGCB(3), VASP(1) 36911873 254 183 185 58 27 91 45 56 35 0 0.000202 1.000 1.000 317 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 CDK5(3), CDK5R1(1), CFL1(2), CHN1(7), LIMK1(5), MAP3K1(6), MYLK(8), NCF2(6), PAK1(3), PDGFRA(14), PIK3CA(96), PIK3R1(10), PLD1(15), PPP1R12B(4), RAC1(15), RALBP1(5), RPS6KB1(5), TRIO(22), VAV1(8), WASF1(3) 26559896 238 179 170 55 28 88 51 46 25 0 0.000910 1.000 1.000 318 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CD2BP2(6), CDC40(3), CLK2(11), CLK3(4), CLK4(2), COL2A1(6), CPSF1(6), CPSF2(5), CPSF3(2), CSTF1(2), CSTF2(2), CSTF2T(2), CSTF3(2), DDX1(5), DDX20(4), DHX15(4), DHX16(9), DHX38(3), DHX8(5), DHX9(7), DICER1(15), DNAJC8(2), FUS(4), GIPC1(3), LSM2(1), METTL3(5), NCBP1(6), NCBP2(3), NONO(5), NUDT21(3), NXF1(4), PABPN1(4), PAPOLA(3), PHF5A(2), POLR2A(11), PRPF18(1), PRPF3(7), PRPF4(2), PRPF4B(7), PRPF8(13), PTBP1(3), PTBP2(4), RBM17(1), RBM5(9), RNGTT(2), RNMT(5), RNPS1(5), SF3A1(2), SF3A2(3), SF3A3(2), SF3B1(6), SF3B2(4), SF3B5(1), SNRPA(3), SNRPA1(1), SNRPB(1), SNRPB2(1), SNRPD2(2), SNRPE(1), SNRPN(8), SNURF(1), SPOP(5), SRPK1(1), SRPK2(8), SRRM1(4), SUPT5H(4), U2AF1(2), U2AF2(2), XRN2(8) 80511676 290 178 288 102 33 71 81 49 56 0 0.804 1.000 1.000 319 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 83 CD14(1), CD19(4), CD1A(7), CD1B(3), CD1C(5), CD1D(5), CD1E(14), CD2(1), CD22(3), CD33(2), CD34(6), CD36(2), CD38(5), CD3D(1), CD4(1), CD44(3), CD5(1), CD59(1), CD7(2), CD8A(2), CD8B(2), CD9(1), CR1(10), CR2(8), CSF1(2), CSF1R(2), CSF2RA(1), CSF3R(3), DNTT(3), EPO(2), EPOR(2), FCER2(1), FCGR1A(1), FLT3(6), FLT3LG(1), GP5(4), GP9(2), HLA-DRA(1), HLA-DRB1(2), IL11RA(2), IL1A(1), IL1B(1), IL1R1(4), IL1R2(1), IL2RA(2), IL3(1), IL3RA(6), IL4(1), IL4R(8), IL5(2), IL5RA(3), IL6(2), IL6R(5), IL7(1), IL7R(6), IL9R(6), ITGA1(4), ITGA2(7), ITGA2B(6), ITGA3(5), ITGA4(13), ITGA5(4), ITGA6(4), ITGAM(8), ITGB3(6), KIT(11), KITLG(1), MME(16), MS4A1(3), TFRC(7), THPO(1), TPO(11) 62037120 282 172 279 114 44 60 79 54 45 0 0.908 1.000 1.000 320 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 65 ADAM10(5), ADAM17(5), ATP6AP1(2), ATP6V0A1(4), ATP6V0A2(3), ATP6V0A4(6), ATP6V0B(1), ATP6V0C(1), ATP6V0D1(2), ATP6V0D2(3), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(3), ATP6V1C1(4), ATP6V1C2(3), ATP6V1D(2), ATP6V1E1(2), ATP6V1E2(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(3), ATP6V1H(3), CASP3(2), CDC42(3), CHUK(6), CSK(1), CXCL1(3), EGFR(19), F11R(3), GIT1(5), IGSF5(4), IKBKB(12), JAM2(2), JUN(1), LYN(8), MAP2K4(2), MAPK10(4), MAPK11(3), MAPK12(3), MAPK13(3), MAPK14(2), MAPK8(4), MAPK9(4), MET(4), NFKB1(5), NFKB2(5), NFKBIA(1), NOD1(7), PAK1(3), PLCG1(8), PLCG2(9), PTPN11(2), PTPRZ1(16), RAC1(15), RELA(2), TCIRG1(8), TJP1(12) 53414859 251 172 243 77 32 56 76 49 38 0 0.250 1.000 1.000 321 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 53 ADORA3(3), ALG6(4), CCKBR(5), CCR2(4), CCR3(6), CELSR1(23), CELSR2(25), CELSR3(17), CHRM2(5), CHRM3(9), CXCR3(1), DRD4(1), EDNRA(2), EMR2(2), EMR3(3), F2R(4), FSHR(12), GHRHR(4), GNRHR(2), GPR116(8), GPR132(4), GPR133(9), GPR135(1), GPR143(1), GPR17(3), GPR18(1), GPR55(1), GPR56(2), GPR61(3), GPR84(3), GRM1(29), GRPR(1), HRH4(3), LGR6(10), LPHN2(11), LPHN3(24), LTB4R2(3), NTSR1(3), OR2M4(6), P2RY11(3), P2RY13(3), PTGFR(2), SMO(3), SSTR2(3), TAAR5(1), TSHR(4), VN1R1(2) 50653530 279 171 278 112 51 62 85 47 34 0 0.460 1.000 1.000 322 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(12), CARM1(5), CCND1(4), CREBBP(39), EP300(39), ERCC3(5), ESR1(6), GRIP1(11), GTF2A1(3), GTF2E1(7), GTF2F1(4), HDAC1(1), HDAC2(3), HDAC3(3), HDAC4(10), HDAC5(3), HDAC6(8), MEF2C(15), NCOR2(24), NR0B1(5), NRIP1(9), PELP1(2), POLR2A(11), TBP(2) 34991761 231 168 223 64 24 47 65 46 48 1 0.0670 1.000 1.000 323 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(3), CD28(3), CD3D(1), CSK(1), CTLA4(2), DAG1(5), EPHB2(3), FBXW7(34), GRAP2(2), ITK(3), ITPKB(5), LAT(3), LCK(5), LCP2(2), MAPK1(9), NCK1(5), NFAT5(13), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(1), NFKBIE(1), NFKBIL1(1), PAK1(3), PAK2(8), PAK3(4), PAK4(1), PAK6(5), PAK7(9), PLCG1(8), PTPRC(19), RAF1(3), RASGRP1(8), RASGRP2(6), RASGRP3(8), RASGRP4(3), SOS1(9), SOS2(11), VAV1(8), ZAP70(2) 42523276 228 167 212 69 34 39 69 32 53 1 0.352 1.000 1.000 324 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT1(2), AKT2(3), AKT3(6), CISH(1), IARS(11), IL13RA1(2), IL4(1), IL4R(8), INPP5D(9), JAK1(11), JAK2(5), JAK3(6), NR0B2(1), PI3(2), PIK3CA(96), PPP1R13B(2), RPS6KB1(5), SERPINA4(7), SHC1(3), SOS1(9), SOS2(11), STAT6(5), TYK2(8) 28058909 214 165 153 46 20 79 44 54 17 0 0.000132 1.000 1.000 325 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(5), AMY2A(3), AMY2B(9), ENPP1(10), ENPP3(8), G6PC(2), GAA(3), GANAB(3), GCK(4), GPI(3), GUSB(5), GYS1(6), GYS2(7), HK1(4), HK2(5), HK3(8), MGAM(32), PGM1(5), PGM3(1), PYGB(5), PYGL(9), PYGM(8), SI(61), UCHL3(1), UGDH(4), UGT1A1(4), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A9(1), UGT2B15(4), UGT2B4(13), UXS1(2) 43197822 248 165 246 84 30 45 81 51 40 1 0.626 1.000 1.000 326 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 58 APC(27), AXIN1(11), CCND1(4), CCND2(2), CSNK1E(6), CTNNB1(6), DVL1(7), DVL2(1), DVL3(9), FBXW2(2), FOSL1(3), FZD1(6), FZD10(5), FZD2(4), FZD3(2), FZD5(1), FZD6(5), FZD7(1), FZD8(2), FZD9(2), GSK3B(3), JUN(1), LDLR(5), MAPK10(4), MAPK9(4), MYC(6), PAFAH1B1(1), PPP2R5C(3), PPP2R5E(3), PRKCA(7), PRKCD(4), PRKCE(3), PRKCG(12), PRKCH(4), PRKCI(3), PRKCQ(8), PRKCZ(3), PRKD1(15), RAC1(15), RHOA(10), SFRP4(12), TCF7(2), WNT1(2), WNT10A(2), WNT10B(1), WNT11(2), WNT16(2), WNT2(3), WNT3(4), WNT4(2), WNT5A(3), WNT5B(1), WNT6(2), WNT7A(3), WNT7B(1) 45758600 262 165 248 88 44 56 83 53 25 1 0.201 1.000 1.000 327 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AADAT(3), AASDHPPT(3), AASS(3), ACAT2(2), AKR1B10(4), ALDH1A3(1), ALDH1B1(4), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), ALDH9A1(3), BBOX1(1), DLST(6), DOT1L(9), ECHS1(2), EHHADH(5), EHMT1(7), EHMT2(11), GCDH(2), HADH(4), HADHA(3), HSD17B10(1), HSD17B4(5), HSD3B7(2), NSD1(73), OGDH(10), OGDHL(12), PIPOX(2), PLOD1(3), PLOD2(7), PLOD3(4), RDH11(2), RDH12(4), SETD1A(11), SETD7(4), SETDB1(10), SHMT1(1), SHMT2(2), SPCS1(2), SPCS3(1), SUV39H1(4), SUV39H2(2), TMLHE(2) 44109520 243 164 242 67 35 39 60 38 65 6 0.107 1.000 1.000 328 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT1(2), AKT2(3), AKT3(6), ASAH1(1), BRAF(10), DAG1(5), DRD2(4), EGFR(19), EPHB2(3), ITPKB(5), ITPR1(16), ITPR2(25), ITPR3(10), KCNJ3(11), KCNJ5(3), KCNJ9(1), MAPK1(9), PI3(2), PIK3CB(7), PITX2(2), PLCB1(21), PLCB2(7), PLCB3(8), PLCB4(17), RAF1(3), RGS20(4), SHC1(3), SOS1(9), SOS2(11), STAT3(6) 44362804 233 164 225 76 40 51 63 55 24 0 0.195 1.000 1.000 329 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACADL(4), ACADM(3), ACOX1(1), ACOX2(2), ACOX3(2), ACSL1(3), ACSL3(3), ACSL4(6), ACSL5(5), ACSL6(3), ADIPOQ(3), ANGPTL4(3), APOA2(1), APOA5(2), AQP7(3), CD36(2), CPT1A(6), CPT1B(4), CPT1C(8), CPT2(7), CYP27A1(3), CYP4A11(13), CYP4A22(9), CYP7A1(6), CYP8B1(6), DBI(4), EHHADH(5), FABP1(4), FABP2(2), FABP3(1), FABP4(4), FABP5(1), FABP6(3), FABP7(1), FADS2(4), GK(5), GK2(8), HMGCS2(2), ILK(4), LPL(4), ME1(2), MMP1(7), NR1H3(1), OLR1(1), PCK1(1), PCK2(4), PDPK1(4), PLTP(2), PPARA(2), PPARD(1), PPARG(1), RXRA(5), RXRB(3), RXRG(7), SCD(1), SCP2(2), SLC27A1(3), SLC27A2(2), SLC27A4(3), SLC27A5(4), SLC27A6(6), SORBS1(7), UBC(5), UCP1(1) 49785711 235 161 234 82 39 55 65 35 40 1 0.347 1.000 1.000 330 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 56 BMP2(5), BMP4(4), BMP5(6), BMP6(7), BMP7(3), BMP8A(1), BMP8B(4), BTRC(1), CSNK1A1(1), CSNK1A1L(4), CSNK1D(1), CSNK1E(6), CSNK1G1(1), CSNK1G2(1), CSNK1G3(1), DHH(1), FBXW11(3), GLI1(7), GLI2(15), GLI3(12), GSK3B(3), HHIP(6), IHH(2), LRP2(42), PRKACA(4), PRKACB(3), PRKACG(3), PRKX(1), PTCH1(14), PTCH2(11), RAB23(2), SHH(2), SMO(3), STK36(6), SUFU(3), WNT1(2), WNT10A(2), WNT10B(1), WNT11(2), WNT16(2), WNT2(3), WNT3(4), WNT3A(1), WNT4(2), WNT5A(3), WNT5B(1), WNT6(2), WNT7A(3), WNT7B(1), WNT8A(2), WNT8B(3), WNT9A(5), WNT9B(3), ZIC2(6) 46317598 237 158 236 89 51 45 83 33 25 0 0.579 1.000 1.000 331 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CALM1(1), CALM2(2), CALM3(2), CAMK1(2), CAMK1G(2), ELK1(2), FPR1(7), GNA15(4), GNB1(3), HRAS(32), MAP2K1(5), MAP2K2(6), MAP2K3(4), MAP2K6(1), MAP3K1(6), MAPK1(9), MAPK14(2), NCF1(2), NCF2(6), NFATC1(9), NFATC2(15), NFATC3(6), NFATC4(3), NFKB1(5), NFKBIA(1), PAK1(3), PIK3C2G(13), PLCB1(21), PPP3CA(2), PPP3CB(1), RAC1(15), RAF1(3), RELA(2), SYT1(8) 29082466 205 157 166 49 52 31 71 29 22 0 0.0103 1.000 1.000 332 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 ARHGDIB(1), CASP10(2), CASP3(2), CASP6(5), CASP7(3), CASP8(61), CFLAR(2), DAXX(5), FADD(4), FAF1(2), JUN(1), LMNA(1), LMNB1(1), LMNB2(8), MAP2K4(2), MAP3K1(6), MAP3K7(8), MAPK8(4), PAK1(3), PAK2(8), PRKDC(28), PTPN13(13), RB1(18), RIPK2(6), SPTAN1(24) 31054098 218 156 205 38 22 42 53 31 68 2 0.000572 1.000 1.000 333 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 AICDA(3), CAD(5), CANT1(3), CTPS2(1), DCK(4), DHODH(6), DPYD(16), DPYS(7), ENTPD1(4), ENTPD3(2), ENTPD4(5), ENTPD5(3), ENTPD6(2), ENTPD8(2), ITPA(4), NME2(1), NME4(2), NME7(4), NT5C1A(2), NT5C1B(7), NT5C2(2), NT5E(1), NUDT2(1), PNPT1(6), POLA1(4), POLA2(2), POLD1(11), POLD2(1), POLD3(4), POLE(11), POLE2(1), POLR1A(10), POLR1B(4), POLR1C(2), POLR2A(11), POLR2B(10), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(3), POLR2G(4), POLR2H(1), POLR2I(1), POLR2J(2), POLR2L(2), POLR3A(9), POLR3B(4), POLR3G(1), POLR3GL(2), POLR3H(1), PRIM1(3), PRIM2(1), RFC5(2), RRM1(1), RRM2(1), RRM2B(1), TXNRD1(6), TXNRD2(2), TYMS(2), UCK1(3), UCK2(4), UMPS(2), UPB1(2), UPP1(3), UPP2(4), UPRT(2) 61520900 236 156 236 94 40 40 67 50 39 0 0.927 1.000 1.000 334 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 43 BCL2(1), CHUK(6), DAXX(5), EGF(9), EGFR(19), ETS1(4), ETS2(7), FOS(6), HOXA7(4), HRAS(32), IKBKB(12), JUN(1), MAP2K1(5), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAP2K7(2), MAP3K1(6), MAP3K5(6), MAPK1(9), MAPK13(3), MAPK14(2), MAPK8(4), NFKB1(5), NFKBIA(1), PRKCA(7), PRKCD(4), PRKCE(3), PRKCG(12), PRKCH(4), PRKCQ(8), RAF1(3), RELA(2), RIPK1(2), SP1(3), TNFRSF1A(1), TNFRSF1B(2), TRAF2(2) 37521254 209 153 179 67 42 38 71 29 28 1 0.236 1.000 1.000 335 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(4), AKT1(2), BDKRB2(3), CALM1(1), CALM2(2), CALM3(2), CAV1(1), FLT1(17), FLT4(13), KDR(13), NOS3(4), PDE2A(4), PDE3A(18), PDE3B(4), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PRKG1(8), PRKG2(2), RYR2(79), SLC7A1(4), SYT1(8) 30730065 205 149 205 74 34 52 58 36 24 1 0.516 1.000 1.000 336 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 ARHGDIB(1), BAG4(6), CASP2(3), CASP3(2), CASP8(61), CRADD(1), FADD(4), JUN(1), LMNA(1), LMNB1(1), LMNB2(8), MADD(10), MAP2K4(2), MAP3K1(6), MAP3K7(8), MAPK8(4), PAK1(3), PAK2(8), PRKDC(28), RB1(18), RIPK1(2), SPTAN1(24), TNFRSF1A(1), TRADD(1), TRAF2(2) 29604604 206 149 193 42 23 34 55 31 61 2 0.00515 1.000 1.000 337 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ADCY4(8), ADCY6(6), ADCY8(28), CACNA1A(14), CACNA1B(13), GNAS(12), GNAT3(6), GNB1(3), GNB3(6), GNG13(2), GRM4(2), ITPR3(10), KCNB1(3), PDE1A(6), PLCB2(7), PRKACA(4), PRKACB(3), PRKACG(3), PRKX(1), SCNN1A(4), SCNN1B(6), SCNN1G(6), TAS1R1(8), TAS1R2(3), TAS1R3(3), TAS2R1(3), TAS2R10(2), TAS2R13(1), TAS2R14(5), TAS2R16(4), TAS2R3(2), TAS2R38(3), TAS2R39(1), TAS2R40(6), TAS2R41(3), TAS2R42(2), TAS2R43(1), TAS2R46(5), TAS2R50(1), TAS2R60(3), TAS2R7(2), TAS2R8(7), TAS2R9(2), TRPM5(5) 43345617 225 147 223 110 49 40 54 46 36 0 0.967 1.000 1.000 338 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(12), BAD(1), BAX(1), BCL2(1), BCL2A1(2), BCL2L1(2), BCL2L2(1), CASP1(2), CASP10(2), CASP2(3), CASP3(2), CASP4(2), CASP6(5), CASP7(3), CASP8(61), CASP9(1), CD40(7), CD40LG(5), CRADD(1), DAXX(5), FADD(4), FAS(5), FASLG(1), IKBKE(5), LTA(4), MCL1(3), NFKB1(5), NFKBIA(1), NGFR(1), NR3C1(6), NTRK1(3), PTPN13(13), RIPK1(2), TFG(1), TNFRSF1A(1), TNFRSF1B(2), TRADD(1), TRAF2(2), TRAF3(6), TRAF6(3) 33094398 188 145 176 36 24 42 38 29 53 2 0.000468 1.000 1.000 339 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AADAT(3), AANAT(1), ACAT2(2), ACMSD(4), AFMID(6), ALDH1A3(1), ALDH1B1(4), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), ALDH9A1(3), AOC2(5), AOC3(5), AOX1(10), ASMT(4), CARM1(5), CAT(4), CYP1A1(2), CYP1A2(5), CYP1B1(5), DDC(7), ECHS1(2), EHHADH(5), GCDH(2), HAAO(1), HADH(4), HADHA(3), HEMK1(1), HSD17B10(1), HSD17B4(5), KMO(1), KYNU(9), LCMT1(2), LCMT2(7), MAOA(1), MAOB(1), METTL2B(4), METTL6(3), NFX1(2), OGDH(10), OGDHL(12), PRMT2(1), PRMT3(6), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(4), TDO2(4), TPH1(2), TPH2(6), WARS(2), WARS2(8) 45967534 199 145 199 66 28 44 62 32 33 0 0.387 1.000 1.000 340 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1A(2), ADH1B(2), ADH4(3), ADH5(3), ADH6(1), ADH7(2), ADHFE1(4), AGK(3), AGPAT1(2), AGPAT2(3), AGPAT3(3), AGPAT4(2), AGPAT6(2), AKR1A1(1), AKR1B1(2), ALDH1A3(1), ALDH1B1(4), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), ALDH9A1(3), CEL(2), DAK(4), DGAT1(1), DGAT2(2), DGKA(4), DGKB(12), DGKD(7), DGKE(5), DGKG(6), DGKH(4), DGKI(11), DGKQ(7), DGKZ(7), GK(5), GK2(8), GLA(3), GLB1(5), GPAM(8), LCT(17), LIPA(3), LIPC(5), LIPF(1), LIPG(4), LPL(4), PNLIP(4), PNLIPRP1(7), PPAP2A(1), PPAP2B(1) 44508420 197 141 196 63 26 43 50 40 38 0 0.201 1.000 1.000 341 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 B2M(10), CALR(2), CANX(3), CD4(1), CD74(3), CD8A(2), CD8B(2), CIITA(12), CREB1(1), CTSS(4), HLA-A(24), HLA-B(26), HLA-C(5), HLA-DMB(1), HLA-DOA(3), HLA-DOB(3), HLA-DQA2(3), HLA-DQB1(2), HLA-DRA(1), HLA-DRB1(2), HLA-E(1), HLA-F(4), HLA-G(2), HSP90AA1(9), HSP90AB1(8), HSPA5(4), IFI30(1), IFNA10(1), IFNA14(1), IFNA16(4), IFNA17(3), IFNA2(1), IFNA21(2), IFNA4(4), IFNA6(1), IFNA8(3), KIR2DL3(1), KIR3DL1(4), KIR3DL2(9), KIR3DL3(3), KLRC1(1), KLRC2(1), KLRC3(3), KLRC4(1), LGMN(5), LTA(4), NFYC(2), PSME1(1), PSME2(2), RFX5(4), RFXAP(2), TAP1(6), TAP2(3), TAPBP(4) 35345030 215 140 203 60 20 44 57 29 65 0 0.0930 1.000 1.000 342 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 CAD(5), CANT1(3), CTPS2(1), DCK(4), DHODH(6), DPYD(16), DPYS(7), ENTPD1(4), ITPA(4), NME2(1), NT5E(1), NUDT2(1), POLB(1), POLD1(11), POLD2(1), POLE(11), POLG(8), POLL(6), POLQ(22), POLR1B(4), POLR2A(11), POLR2B(10), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(3), POLR2G(4), POLR2H(1), POLR2I(1), POLR2J(2), POLR2L(2), POLRMT(6), RRM1(1), RRM2(1), TXNRD1(6), TYMS(2), UCK1(3), UCK2(4), UMPS(2), UNG(2), UPB1(2), UPP1(3) 43605398 186 138 186 61 27 33 59 32 35 0 0.432 1.000 1.000 343 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(8), ACTB(5), ACTG1(3), ARHGEF2(3), CD14(1), CDC42(3), CDH1(5), CTNNB1(6), CTTN(10), FYN(5), HCLS1(2), ITGB1(16), KRT18(1), LY96(2), NCK1(5), NCK2(7), NCL(4), OCLN(1), PRKCA(7), RHOA(10), ROCK1(19), ROCK2(10), TLR4(16), TLR5(4), TUBA1B(5), TUBA3C(10), TUBA3D(3), TUBA3E(7), TUBA4A(1), TUBA8(2), TUBAL3(4), TUBB(3), TUBB1(3), TUBB2A(1), TUBB3(1), TUBB6(4), TUBB8(2), WAS(2), WASL(2), YWHAQ(3), YWHAZ(2) 39948764 208 137 202 74 30 48 64 27 38 1 0.437 1.000 1.000 344 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(8), ACTB(5), ACTG1(3), ARHGEF2(3), CD14(1), CDC42(3), CDH1(5), CTNNB1(6), CTTN(10), FYN(5), HCLS1(2), ITGB1(16), KRT18(1), LY96(2), NCK1(5), NCK2(7), NCL(4), OCLN(1), PRKCA(7), RHOA(10), ROCK1(19), ROCK2(10), TLR4(16), TLR5(4), TUBA1B(5), TUBA3C(10), TUBA3D(3), TUBA3E(7), TUBA4A(1), TUBA8(2), TUBAL3(4), TUBB(3), TUBB1(3), TUBB2A(1), TUBB3(1), TUBB6(4), TUBB8(2), WAS(2), WASL(2), YWHAQ(3), YWHAZ(2) 39948764 208 137 202 74 30 48 64 27 38 1 0.437 1.000 1.000 345 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 AANAT(1), ACAT2(2), ACMSD(4), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), AOC2(5), AOC3(5), AOX1(10), ASMT(4), CAT(4), CYP19A1(3), CYP1A1(2), CYP1A2(5), CYP2A13(4), CYP2A6(2), CYP2A7(4), CYP2B6(5), CYP2C18(3), CYP2C19(6), CYP2C8(6), CYP2C9(7), CYP2D6(5), CYP2E1(6), CYP2F1(2), CYP2J2(7), CYP3A4(6), CYP3A5(1), CYP3A7(1), CYP4B1(3), CYP51A1(1), DDC(7), ECHS1(2), EHHADH(5), GCDH(2), HAAO(1), HADHA(3), KMO(1), KYNU(9), MAOA(1), MAOB(1), SDS(1), TDO2(4), TPH1(2), WARS(2), WARS2(8) 41837003 186 137 186 66 25 40 60 33 27 1 0.552 1.000 1.000 346 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(5), ACSS2(2), ACYP1(1), ADH1A(2), ADH1B(2), ADH4(3), ADH5(3), ADH6(1), ADH7(2), ADHFE1(4), AKR1A1(1), ALDH1A3(1), ALDH1B1(4), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH3B1(3), ALDH3B2(4), ALDH7A1(2), ALDH9A1(3), ALDOA(1), ALDOB(5), ALDOC(4), DLAT(4), DLD(1), ENO1(2), ENO2(1), ENO3(3), FBP2(1), G6PC(2), G6PC2(7), GAPDH(2), GAPDHS(1), GCK(4), GPI(3), HK1(4), HK2(5), HK3(8), LDHA(1), LDHAL6A(2), LDHAL6B(6), LDHB(1), LDHC(4), PDHA1(4), PDHA2(14), PDHB(1), PFKL(6), PFKM(6), PFKP(6), PGAM1(2), PGAM2(4), PGAM4(1), PGK1(2), PGK2(5), PGM1(5), PGM3(1), PKLR(3), TPI1(4) 44194172 183 136 183 76 29 48 45 29 32 0 0.768 1.000 1.000 347 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 69 ADH1A(2), ADH1B(2), ADH4(3), ADH5(3), ADH6(1), ADH7(2), ADHFE1(4), AKR1C1(1), AKR1C4(3), ALDH1A3(1), ALDH3A1(1), ALDH3B1(3), ALDH3B2(4), CYP1A1(2), CYP1A2(5), CYP1B1(5), CYP2B6(5), CYP2C18(3), CYP2C19(6), CYP2C8(6), CYP2C9(7), CYP2E1(6), CYP2F1(2), CYP2S1(1), CYP3A4(6), CYP3A43(2), CYP3A5(1), CYP3A7(1), EPHX1(2), GSTA1(3), GSTA2(1), GSTA3(2), GSTA5(2), GSTK1(2), GSTM1(1), GSTM2(3), GSTM3(1), GSTM4(5), GSTM5(1), GSTP1(1), GSTT1(1), GSTZ1(1), MGST1(1), MGST2(1), MGST3(2), UGT1A1(4), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A9(1), UGT2A1(6), UGT2A3(7), UGT2B10(11), UGT2B11(9), UGT2B15(4), UGT2B17(5), UGT2B28(6), UGT2B4(13), UGT2B7(7) 43717129 204 136 204 82 28 40 68 39 28 1 0.864 1.000 1.000 348 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(4), AGTR2(2), CALM1(1), CALM2(2), CALM3(2), CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), CDK5(3), F2(3), FYN(5), GNA11(4), GNAI1(2), GNB1(3), HRAS(32), JAK2(5), MAP2K1(5), MAP2K2(6), MAPK1(9), MAPK14(2), MAPK8(4), MAPT(8), MYLK(8), PLCG1(8), PRKCA(7), PTK2B(4), RAF1(3), SHC1(3), SOS1(9), STAT1(7), STAT3(6), STAT5A(3), SYT1(8) 31586294 179 135 149 49 45 36 60 23 15 0 0.0252 1.000 1.000 349 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1C4(3), AKR1D1(3), ARSD(4), ARSE(2), CARM1(5), CYP11B1(6), CYP11B2(4), CYP19A1(3), HEMK1(1), HSD11B2(3), HSD17B1(2), HSD17B2(2), HSD17B3(2), HSD17B7(1), HSD17B8(3), HSD3B1(4), HSD3B2(4), LCMT1(2), LCMT2(7), METTL2B(4), METTL6(3), PRMT2(1), PRMT3(6), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(4), STS(3), SULT1E1(5), SULT2A1(2), UGT1A1(4), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A9(1), UGT2A1(6), UGT2A3(7), UGT2B10(11), UGT2B11(9), UGT2B15(4), UGT2B17(5), UGT2B28(6), UGT2B4(13), UGT2B7(7) 38193915 183 134 183 61 34 33 60 36 20 0 0.433 1.000 1.000 350 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(4), ACTN1(4), ACTN2(11), BCAR1(3), BCR(2), CAPN1(3), CAPNS1(2), CAPNS2(2), CAV1(1), CRKL(3), CSK(1), FYN(5), HRAS(32), ITGA1(4), ITGB1(16), JUN(1), MAP2K1(5), MAP2K2(6), MAPK1(9), MAPK8(4), PPP1R12B(4), PTK2(8), PXN(2), RAF1(3), ROCK1(19), SHC1(3), SOS1(9), TLN1(24), VCL(6), ZYX(2) 35893183 198 134 167 44 42 30 75 29 22 0 0.00685 1.000 1.000 351 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(21), CALM1(1), CALM2(2), CALM3(2), CREB1(1), ELK1(2), FOS(6), GNAI1(2), GNAS(12), GNB1(3), HRAS(32), JUN(1), MAP2K1(5), NFATC1(9), NFATC2(15), NFATC3(6), NFATC4(3), PLCG1(8), PPP3CA(2), PPP3CB(1), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PRKCA(7), RAF1(3), RPS6KA3(4), SYT1(8) 26575351 172 133 148 36 42 29 58 25 18 0 0.00117 1.000 1.000 352 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 ADRB1(3), AKT1(2), APC(27), ASAH1(1), DAG1(5), DLG4(3), EPHB2(3), GNAI1(2), ITPR1(16), ITPR2(25), ITPR3(10), KCNJ3(11), KCNJ5(3), KCNJ9(1), MAPK1(9), PITX2(2), PTX3(4), RAC1(15), RHO(3), RYR1(34) 34733583 179 132 164 60 43 40 40 28 28 0 0.119 1.000 1.000 353 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(3), ALPL(4), ALPP(3), ALPPL2(7), ASCC3(12), ATP13A2(2), DDX18(3), DDX19A(2), DDX23(3), DDX4(4), DDX41(5), DDX47(2), DDX50(1), DDX51(3), DDX52(6), DDX54(5), DDX55(3), DDX56(4), DHFR(3), DHX58(2), ENTPD7(4), EP400(19), ERCC2(5), ERCC3(5), FPGS(2), GGH(3), IFIH1(6), MOV10L1(5), NUDT5(2), NUDT8(1), QDPR(3), RAD54B(6), RAD54L(5), RUVBL2(2), SETX(12), SKIV2L2(4), SMARCA2(13), SMARCA5(2) 47813003 176 131 176 54 22 34 58 35 27 0 0.388 1.000 1.000 354 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG1(3), ACTG2(5), ACTR2(1), AKT1(2), ANGPTL2(3), CDC42(3), CFL1(2), FLNA(23), FLNC(15), FSCN1(2), FSCN2(1), FSCN3(6), GDI1(4), GDI2(5), LIMK1(5), MYH2(28), MYLK(8), MYLK2(5), PAK1(3), PAK2(8), PAK3(4), PAK4(1), PAK6(5), PAK7(9), PFN1(1), RHO(3), ROCK1(19), ROCK2(10), VASP(1), WASF1(3), WASL(2) 36437833 190 131 190 75 31 45 53 28 33 0 0.677 1.000 1.000 355 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(4), CAPN1(3), CAPN2(6), CAPNS1(2), CAPNS2(2), CXCR3(1), EGF(9), EGFR(19), HRAS(32), ITGA1(4), ITGB1(16), MAPK1(9), MYLK(8), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PTK2(8), PXN(2), TLN1(24) 24863168 165 127 133 44 38 24 57 26 19 1 0.0730 1.000 1.000 356 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 ATF2(1), CDC42(3), CREB1(1), DAXX(5), ELK1(2), HRAS(32), HSPB2(2), MAP2K4(2), MAP2K6(1), MAP3K1(6), MAP3K5(6), MAP3K7(8), MAP3K9(9), MAPK14(2), MAPKAPK5(2), MAX(1), MEF2A(3), MEF2B(5), MEF2C(15), MEF2D(1), MKNK1(1), MYC(6), PLA2G4A(3), RAC1(15), RIPK1(2), RPS6KA5(5), SHC1(3), STAT1(7), TGFB1(1), TGFB2(3), TGFB3(1), TGFBR1(2), TRADD(1), TRAF2(2) 27836826 159 127 126 38 30 33 53 22 21 0 0.0322 1.000 1.000 357 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(9), ATP4A(6), ATP4B(2), ATP5A1(1), ATP5B(2), ATP5C1(1), ATP5F1(1), ATP5G1(1), ATP5G2(2), ATP5G3(1), ATP5H(1), ATP5L(1), ATP5O(1), ATP6AP1(2), ATP6V0A1(4), ATP6V0A2(3), ATP6V0A4(6), ATP6V0B(1), ATP6V0C(1), ATP6V0D1(2), ATP6V0D2(3), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(3), ATP6V1C1(4), ATP6V1C2(3), ATP6V1D(2), ATP6V1E1(2), ATP6V1E2(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(3), ATP6V1H(3), COX10(3), COX15(4), COX17(2), COX4I2(1), COX5A(2), COX5B(1), COX7B2(2), COX8A(1), CYC1(3), LHPP(1), NDUFA1(1), NDUFA12(1), NDUFA13(3), NDUFA2(1), NDUFA3(1), NDUFA5(3), NDUFA7(2), NDUFA9(2), NDUFB10(1), NDUFB2(2), NDUFB3(2), NDUFB4(1), NDUFB6(1), NDUFB8(2), NDUFB9(2), NDUFS1(1), NDUFS2(3), NDUFS3(2), NDUFS4(1), NDUFS5(3), NDUFS7(2), NDUFS8(2), NDUFV1(3), NDUFV3(1), PPA1(1), SDHA(7), SDHB(1), SDHC(1), TCIRG1(8), UQCRC1(1), UQCRC2(1), UQCRFS1(4) 42404427 166 125 165 46 17 36 56 31 26 0 0.138 1.000 1.000 358 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(35), B3GALT4(4), CDR1(7), DGKI(11), IL6ST(4), MRPL19(3), PIGK(6), RPL10(3), RPL12(1), RPL13A(2), RPL15(1), RPL17(1), RPL18A(1), RPL22(1), RPL23(1), RPL26(1), RPL27(1), RPL28(1), RPL3(5), RPL31(2), RPL32(1), RPL36(2), RPL37(2), RPL39(1), RPL3L(1), RPL4(1), RPL5(2), RPL6(3), RPL7A(1), RPL8(1), RPLP0(4), RPLP2(2), RPS10(2), RPS13(2), RPS15(1), RPS19(1), RPS20(1), RPS21(1), RPS23(1), RPS25(2), RPS26(1), RPS27A(1), RPS28(1), RPS3(1), RPS5(1), RPS6KA1(10), RPS6KA2(6), RPS6KA3(4), RPS6KA6(8), RPS6KB1(5), RPS6KB2(2), SLC36A2(3), TBC1D10C(3), TSPAN9(1), UBA52(3), UBB(1), UBC(5) 39813299 179 125 179 74 21 38 68 24 28 0 0.945 1.000 1.000 359 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 ACVR1(5), APC(27), ATF2(1), AXIN1(11), BMP10(2), BMP2(5), BMP4(4), BMP5(6), BMP7(3), BMPR2(6), CHRD(12), CTNNB1(6), DVL1(7), FZD1(6), GSK3B(3), MAP3K7(8), MEF2C(15), NKX2-5(1), NOG(2), NPPA(3), NPPB(2), RFC1(3), TGFB1(1), TGFB2(3), TGFB3(1), TGFBR1(2), TGFBR2(25), TGFBR3(5), WNT1(2) 27783473 177 124 166 39 24 41 39 36 36 1 0.00657 1.000 1.000 360 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ADH1A(2), ADH1B(2), ADH4(3), ADH5(3), ADH6(1), ADH7(2), ADHFE1(4), ALDH1A3(1), ALDH3A1(1), ALDH3B1(3), ALDH3B2(4), AOC2(5), AOC3(5), AOX1(10), CARM1(5), COMT(1), DBH(8), DCT(4), DDC(7), ECH1(2), ESCO1(4), ESCO2(4), FAH(2), GOT1(1), GOT2(3), GSTZ1(1), HEMK1(1), HGD(4), HPD(3), LCMT1(2), LCMT2(7), MAOA(1), MAOB(1), METTL2B(4), METTL6(3), PNMT(1), PRMT2(1), PRMT3(6), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(4), SH3GLB1(2), TAT(1), TH(3), TPO(11), TYR(8), TYRP1(4) 45187717 163 124 162 53 27 40 48 21 27 0 0.247 1.000 1.000 361 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(10), COL4A2(9), COL4A3(19), COL4A4(14), COL4A5(14), COL4A6(4), F10(4), F11(2), F12(2), F2(3), F2R(4), F5(20), F8(8), F9(9), FGA(10), FGB(4), FGG(6), KLKB1(7), PROC(2), PROS1(9), SERPINC1(4), SERPING1(5) 33727835 169 124 168 55 16 52 46 29 26 0 0.611 1.000 1.000 362 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(2), ADH1B(2), ADH4(3), ADH6(1), ADH7(2), ADHFE1(4), AGPAT1(2), AGPAT2(3), AGPAT3(3), AGPAT4(2), AKR1A1(1), AKR1B1(2), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), CEL(2), DGAT1(1), DGKA(4), DGKB(12), DGKD(7), DGKE(5), DGKG(6), DGKH(4), DGKQ(7), DGKZ(7), GK(5), GLA(3), GLB1(5), LCT(17), LIPC(5), LIPF(1), LIPG(4), LPL(4), PNLIP(4), PNLIPRP1(7), PPAP2A(1), PPAP2B(1) 36570399 162 123 161 54 21 32 42 30 37 0 0.323 1.000 1.000 363 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 ALOX12(3), ALOX12B(4), ALOX15B(5), ALOX5(5), CBR3(1), CYP2B6(5), CYP2C18(3), CYP2C19(6), CYP2C8(6), CYP2C9(7), CYP2E1(6), CYP2J2(7), CYP2U1(1), CYP4A11(13), CYP4A22(9), CYP4F2(7), CYP4F3(3), DHRS4(2), EPHX2(4), GGT1(4), GPX2(1), GPX5(2), GPX6(4), GPX7(1), LTA4H(1), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PTGDS(2), PTGES2(1), PTGIS(7), PTGS1(7), PTGS2(4), TBXAS1(5) 29595932 153 121 153 52 20 32 47 25 28 1 0.274 1.000 1.000 364 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT1(2), AKT2(3), AKT3(6), ANKRD6(3), APC(27), AXIN1(11), AXIN2(7), CER1(1), CSNK1A1(1), CTNNB1(6), DACT1(6), DKK1(2), DKK2(5), DKK3(2), DVL1(7), FSTL1(3), GSK3A(2), GSK3B(3), LRP1(34), MVP(5), NKD1(8), NKD2(3), PIN1(1), PTPRA(4), SENP2(3), SFRP1(2), TSHB(2), WIF1(1) 30754359 160 121 159 55 22 38 42 32 25 1 0.449 1.000 1.000 365 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCR3(6), CFL1(2), GNAS(12), GNB1(3), HRAS(32), LIMK1(5), MAP2K1(5), MAPK1(9), NOX1(6), PIK3C2G(13), PLCB1(21), PPP1R12B(4), PRKCA(7), PTK2(8), RAF1(3), ROCK2(10) 19131878 146 120 114 33 32 24 57 15 18 0 0.0556 1.000 1.000 366 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 64 ACHE(2), AGPAT1(2), AGPAT2(3), AGPAT3(3), AGPAT4(2), AGPAT6(2), CDIPT(1), CDS1(3), CDS2(3), CHAT(9), CHKB(1), CHPT1(2), CRLS1(1), DGKA(4), DGKB(12), DGKD(7), DGKE(5), DGKG(6), DGKH(4), DGKI(11), DGKQ(7), DGKZ(7), ESCO1(4), ESCO2(4), ETNK1(1), ETNK2(3), GNPAT(3), GPAM(8), GPD1(1), GPD2(5), LCAT(2), LYPLA1(1), LYPLA2(1), PCYT1A(2), PCYT1B(2), PHOSPHO1(1), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PLD1(15), PLD2(1), PPAP2A(1), PPAP2B(1), PTDSS1(7), PTDSS2(2), SH3GLB1(2) 49774432 181 120 180 55 19 37 53 29 43 0 0.248 1.000 1.000 367 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(8), ANAPC2(1), ANAPC4(2), ANAPC5(1), ANAPC7(1), BTRC(1), CDC16(2), CDC20(2), CDC23(4), CDC26(1), CDC27(8), CUL1(11), CUL2(3), CUL3(14), FBXW11(3), FBXW7(34), FZR1(4), ITCH(7), RBX1(3), SKP1(1), SKP2(4), SMURF1(3), SMURF2(6), TCEB1(2), UBA1(1), UBE2D2(1), UBE2D3(1), UBE2D4(1), UBE2E1(1), WWP1(7), WWP2(5) 30450179 143 117 134 40 16 32 35 28 31 1 0.355 1.000 1.000 368 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ADH1A(2), ADH1B(2), ADH4(3), ADH6(1), ADH7(2), ADHFE1(4), AKR1A1(1), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH3B1(3), ALDH3B2(4), ALDH9A1(3), ALDOA(1), ALDOB(5), ALDOC(4), DLAT(4), DLD(1), ENO1(2), ENO2(1), ENO3(3), FBP2(1), G6PC(2), GAPDH(2), GCK(4), GPI(3), HK1(4), HK2(5), HK3(8), LDHA(1), LDHB(1), LDHC(4), PDHA1(4), PDHA2(14), PDHB(1), PFKM(6), PFKP(6), PGAM1(2), PGK1(2), PGM1(5), PGM3(1), PKLR(3), TPI1(4) 37124672 150 116 150 57 22 39 37 25 27 0 0.610 1.000 1.000 369 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ADH1A(2), ADH1B(2), ADH4(3), ADH6(1), ADH7(2), ADHFE1(4), AKR1A1(1), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH3B1(3), ALDH3B2(4), ALDH9A1(3), ALDOA(1), ALDOB(5), ALDOC(4), DLAT(4), DLD(1), ENO1(2), ENO2(1), ENO3(3), FBP2(1), G6PC(2), GAPDH(2), GCK(4), GPI(3), HK1(4), HK2(5), HK3(8), LDHA(1), LDHB(1), LDHC(4), PDHA1(4), PDHA2(14), PDHB(1), PFKM(6), PFKP(6), PGAM1(2), PGK1(2), PGM1(5), PGM3(1), PKLR(3), TPI1(4) 37124672 150 116 150 57 22 39 37 25 27 0 0.610 1.000 1.000 370 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 A4GALT(1), B3GALNT1(1), B3GALT1(2), B3GALT2(2), B3GALT4(4), B3GALT5(1), B3GNT1(3), B3GNT2(1), B3GNT3(5), B3GNT5(2), B4GALNT1(3), B4GALT1(1), B4GALT2(5), B4GALT3(1), B4GALT4(2), B4GALT6(2), FUT2(2), FUT3(3), FUT5(4), FUT6(2), FUT7(1), FUT9(11), GBGT1(4), GCNT2(5), PIGA(2), PIGB(3), PIGC(2), PIGG(6), PIGK(6), PIGN(3), PIGO(4), PIGP(1), PIGQ(4), PIGS(2), PIGT(2), PIGU(1), PIGV(1), PIGX(2), PIGZ(2), ST3GAL1(2), ST3GAL2(1), ST3GAL3(4), ST3GAL4(1), ST3GAL5(6), ST3GAL6(4), ST6GALNAC3(8), ST6GALNAC5(5), ST6GALNAC6(4), ST8SIA1(3), ST8SIA5(7), UGCG(1) 36951387 155 116 153 60 29 37 52 18 19 0 0.471 1.000 1.000 371 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(17), AR(6), ESR1(6), ESR2(1), ESRRA(5), HNF4A(7), NPM1(2), NR0B1(5), NR1D1(1), NR1D2(3), NR1H2(2), NR1H3(1), NR1I2(4), NR1I3(1), NR2C2(1), NR2E1(8), NR2F1(3), NR2F2(9), NR2F6(1), NR3C1(6), NR4A1(2), NR4A2(4), NR5A2(5), PGR(5), PPARA(2), PPARD(1), PPARG(1), RARA(4), RARB(6), RARG(11), ROR1(9), RORA(3), RORC(3), RXRA(5), RXRB(3), RXRG(7), THRA(6), THRB(1), VDR(2) 31972831 169 116 167 48 30 29 59 24 26 1 0.102 1.000 1.000 372 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(2), AGPAT1(2), AGPAT2(3), AGPAT3(3), AGPAT4(2), AGPS(5), CDIPT(1), CDS1(3), CDS2(3), CHAT(9), CHKB(1), CLC(3), CPT1B(4), DGKA(4), DGKB(12), DGKD(7), DGKE(5), DGKG(6), DGKH(4), DGKQ(7), DGKZ(7), ETNK1(1), GNPAT(3), GPD1(1), GPD2(5), LCAT(2), LGALS13(1), LYPLA1(1), LYPLA2(1), PAFAH1B1(1), PAFAH2(1), PCYT1A(2), PCYT1B(2), PLA2G1B(2), PLA2G2A(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PLCB2(7), PLCG1(8), PLCG2(9), PPAP2A(1), PPAP2B(1) 37943344 153 115 152 51 20 25 45 26 37 0 0.365 1.000 1.000 373 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(15), ACACB(20), ACAT2(2), ACOT12(3), ACSS1(5), ACSS2(2), ACYP1(1), AKR1B1(2), ALDH1A3(1), ALDH1B1(4), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), ALDH9A1(3), DLAT(4), DLD(1), GLO1(2), GRHPR(1), HAGH(1), LDHA(1), LDHAL6A(2), LDHAL6B(6), LDHB(1), LDHC(4), LDHD(1), MDH1(1), MDH2(1), ME1(2), ME2(3), ME3(7), PC(14), PCK1(1), PCK2(4), PDHA1(4), PDHA2(14), PDHB(1), PKLR(3) 35530493 143 114 143 55 30 26 40 27 20 0 0.785 1.000 1.000 374 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(2), AKR1B10(4), B4GALT1(1), B4GALT2(5), G6PC(2), G6PC2(7), GAA(3), GALK1(1), GALK2(2), GALT(2), GANC(6), GCK(4), GLA(3), GLB1(5), HK1(4), HK2(5), HK3(8), HSD3B7(2), LALBA(1), LCT(17), MGAM(32), PFKL(6), PFKM(6), PFKP(6), PGM1(5), PGM3(1), RDH11(2), RDH12(4), UGP2(2) 29300594 148 113 147 38 26 32 45 21 23 1 0.0230 1.000 1.000 375 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA2(1), ACADL(4), ACADM(3), ACADS(2), ACADSB(3), ACADVL(4), ACAT2(2), ACOX1(1), ACOX3(2), ACSL1(3), ACSL3(3), ACSL4(6), ACSL5(5), ACSL6(3), ADH1A(2), ADH1B(2), ADH4(3), ADH5(3), ADH6(1), ADH7(2), ADHFE1(4), ALDH1A3(1), ALDH1B1(4), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), ALDH9A1(3), CPT1A(6), CPT1B(4), CPT1C(8), CPT2(7), CYP4A11(13), CYP4A22(9), ECHS1(2), EHHADH(5), GCDH(2), HADH(4), HADHA(3), HADHB(4), HSD17B10(1), HSD17B4(5) 37199236 146 113 146 50 14 36 39 32 25 0 0.485 1.000 1.000 376 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(14), BAIAP2(2), CASP1(2), CASP3(2), CASP7(3), CASP8(61), GAPDH(2), INSR(3), ITCH(7), MAGI1(14), MAGI2(20), RERE(7), WWP1(7), WWP2(5) 18243627 149 113 137 37 17 34 29 24 43 2 0.0618 1.000 1.000 377 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(2), AKT2(3), AKT3(6), ARHGEF11(4), BCL2(1), CDC42(3), DLG4(3), GNA13(2), LPA(16), MAP2K4(2), MAP3K1(6), MAP3K5(6), MAPK8(4), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(1), NFKBIE(1), NFKBIL1(1), PDK1(3), PHKA2(9), PI3(2), PIK3CB(7), PLD1(15), PLD2(1), PLD3(2), PTK2(8), RDX(1), ROCK1(19), ROCK2(10), SERPINA4(7), SRF(1), TBXA2R(1) 37381120 158 113 158 58 12 41 50 27 28 0 0.724 1.000 1.000 378 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(8), AKT1(2), AKT2(3), AKT3(6), DAG1(5), ITPKB(5), ITPR1(16), ITPR2(25), ITPR3(10), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(1), NFKBIE(1), NFKBIL1(1), PDK1(3), PHKA2(9), PIK3CB(7), PITX2(2), PLD1(15), PLD2(1), PLD3(2), VN1R1(2) 34047169 135 112 135 52 15 43 31 25 21 0 0.510 1.000 1.000 379 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOA(1), ALDOB(5), ALDOC(4), DLAT(4), DLD(1), ENO1(2), ENO2(1), ENO3(3), FBP2(1), G6PC(2), GAPDH(2), GAPDHS(1), GCK(4), GOT1(1), GOT2(3), GPI(3), HK1(4), HK2(5), HK3(8), LDHA(1), LDHAL6B(6), LDHB(1), LDHC(4), MDH1(1), MDH2(1), PC(14), PCK1(1), PDHA1(4), PDHA2(14), PDHB(1), PDHX(4), PFKL(6), PFKM(6), PFKP(6), PGAM1(2), PGAM2(4), PGK1(2), PGK2(5), PKLR(3), TNFAIP1(4), TPI1(4) 32250973 149 110 149 56 25 39 39 24 22 0 0.450 1.000 1.000 380 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 ANKHD1(17), EEF1A2(3), EEF1B2(1), EEF1D(1), EEF1G(2), EEF2(5), EEF2K(6), EIF1AX(1), EIF2AK1(8), EIF2AK2(1), EIF2AK3(7), EIF2B1(1), EIF2B2(3), EIF2B3(4), EIF2B4(4), EIF2B5(4), EIF2S1(2), EIF2S2(6), EIF2S3(1), EIF4A1(3), EIF4A2(2), EIF4E(1), EIF4EBP1(1), EIF4G1(19), EIF4G3(9), EIF5(3), EIF5A(5), EIF5B(6), ETF1(3), GSPT2(6), PABPC1(1), PABPC3(7), PAIP1(5), SLC35A4(1) 33334084 149 110 148 41 16 32 49 28 24 0 0.286 1.000 1.000 381 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(3), AARS2(5), CARS(4), CARS2(1), DARS(5), DARS2(3), EARS2(4), EPRS(4), FARS2(4), FARSA(1), FARSB(7), GARS(1), HARS(1), HARS2(3), IARS(11), IARS2(3), KARS(3), LARS(5), LARS2(2), MARS(2), MARS2(5), MTFMT(4), NARS(2), NARS2(2), PARS2(5), QARS(5), RARS(1), RARS2(3), SARS(1), TARS(6), TARS2(4), VARS(6), VARS2(4), WARS(2), WARS2(8), YARS(7), YARS2(4) 41248531 141 108 141 38 16 29 47 28 21 0 0.154 1.000 1.000 382 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(3), CALM1(1), CALM2(2), CALM3(2), CRKL(3), HRAS(32), JUN(1), MAP2K1(5), MAP2K2(6), MAP2K3(4), MAP2K4(2), MAP3K1(6), MAPK1(9), MAPK14(2), MAPK8(4), PAK1(3), PLCG1(8), PRKCA(7), PTK2B(4), RAC1(15), RAF1(3), SHC1(3), SOS1(9), SYT1(8) 21663863 142 108 105 30 41 20 51 18 12 0 0.00676 1.000 1.000 383 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(3), AARS2(5), ABAT(6), ACY3(3), ADSL(5), ADSS(4), ADSSL1(6), AGXT(2), AGXT2(5), ASL(2), ASNS(5), ASPA(4), ASRGL1(1), ASS1(2), CAD(5), CRAT(6), DARS(5), DARS2(3), DDO(1), DLAT(4), DLD(1), GAD1(4), GAD2(7), GOT1(1), GOT2(3), GPT(1), GPT2(3), NARS(2), NARS2(2), PC(14), PDHA1(4), PDHA2(14), PDHB(1) 28751414 134 107 134 44 19 34 42 20 19 0 0.294 1.000 1.000 384 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAD(2), ALAS2(5), BLVRA(3), COX10(3), COX15(4), CP(8), CPOX(1), EARS2(4), EPRS(4), FECH(1), FTMT(6), GUSB(5), HCCS(2), HMOX1(1), HMOX2(1), MMAB(2), PPOX(1), UGT1A1(4), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A9(1), UGT2A1(6), UGT2A3(7), UGT2B10(11), UGT2B11(9), UGT2B15(4), UGT2B17(5), UGT2B28(6), UGT2B4(13), UGT2B7(7), UROD(1), UROS(4) 32129286 144 107 144 59 17 22 57 35 13 0 0.961 1.000 1.000 385 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2A1(3), GTF2A1L(8), GTF2A2(1), GTF2B(1), GTF2E1(7), GTF2F1(4), GTF2F2(3), GTF2H1(3), GTF2H3(2), GTF2H4(3), GTF2I(4), GTF2IRD1(5), STON1(6), TAF1(13), TAF10(4), TAF13(1), TAF1L(25), TAF2(8), TAF4(5), TAF4B(5), TAF5(7), TAF5L(4), TAF6(5), TAF6L(2), TAF7(2), TAF7L(4), TAF9(3), TBPL1(2), TBPL2(1) 27383127 141 106 140 51 18 32 38 28 25 0 0.791 1.000 1.000 386 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR2(1), ARHGAP1(4), ARHGAP4(9), ARHGAP5(10), ARHGAP6(8), ARHGEF1(9), ARHGEF11(4), ARHGEF5(4), ARPC1B(3), ARPC2(2), ARPC3(1), ARPC4(1), BAIAP2(2), CFL1(2), DIAPH1(7), GSN(5), LIMK1(5), MYLK(8), OPHN1(6), PFN1(1), PIP5K1A(4), PIP5K1B(8), PPP1R12B(4), ROCK1(19), TLN1(24), VCL(6) 34447041 157 106 157 64 24 35 47 32 19 0 0.918 1.000 1.000 387 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 ARNTL(2), AZIN1(3), BTG1(1), CBX3(2), CEBPB(1), CLOCK(6), CRY1(6), CRY2(3), DAZAP2(2), DNAJA1(3), EIF4G2(9), ETV6(6), G0S2(1), GFRA1(8), GSTM3(1), GSTP1(1), HERPUD1(5), HSPA8(10), IDI1(1), KLF9(1), MYF6(2), NCKAP1(8), NCOA4(7), NR1D2(3), PER1(7), PER2(2), PPP1R3C(2), PPP2CB(3), SF3A3(2), SUMO3(1), TUBB3(1), UCP3(5), UGP2(2), VAPA(1), ZFR(5) 27841024 123 105 123 43 16 23 45 23 16 0 0.804 1.000 1.000 388 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(9), GABBR1(3), GPRC5A(2), GPRC5B(2), GPRC5C(3), GPRC5D(1), GRM1(29), GRM2(10), GRM3(29), GRM4(2), GRM5(12), GRM7(19), GRM8(23) 15909035 144 105 142 45 31 28 43 29 13 0 0.0832 1.000 1.000 389 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(16), C5(11), C6(25), C7(12), ICAM1(6), IL1A(1), IL6(2), ITGA4(13), ITGAL(7), ITGB1(16), ITGB2(4), SELP(15), SELPLG(1), VCAM1(10) 18856603 139 104 138 36 13 37 40 21 28 0 0.0429 1.000 1.000 390 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(4), F11(2), F12(2), F13B(13), F2(3), F5(20), F7(3), F8(8), F9(9), FGA(10), FGB(4), FGG(6), LPA(16), PLAT(3), PLG(13), SERPINB2(2), SERPINE1(8), VWF(19) 26846529 145 102 144 40 14 39 44 26 22 0 0.137 1.000 1.000 391 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(4), POLA2(2), POLB(1), POLD1(11), POLD2(1), POLD3(4), POLE(11), POLE2(1), POLG(8), POLG2(2), POLH(3), POLI(4), POLK(9), POLL(6), POLM(2), POLQ(22), PRIM1(3), PRIM2(1), REV1(3), REV3L(25), RFC5(2) 30787268 125 102 124 32 20 28 31 20 26 0 0.131 1.000 1.000 392 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(2), AKR1B10(4), ALDOA(1), ALDOB(5), ALDOC(4), FBP2(1), FPGT(5), FUK(3), GMDS(5), GMPPA(1), HK1(4), HK2(5), HK3(8), HSD3B7(2), KHK(3), LHPP(1), MPI(5), MTMR1(1), MTMR2(5), MTMR6(4), PFKFB1(3), PFKFB2(5), PFKFB3(2), PFKFB4(1), PFKL(6), PFKM(6), PFKP(6), PGM2(3), PHPT1(1), PMM2(2), RDH11(2), RDH12(4), SORD(2), TPI1(4), TSTA3(2) 28192307 118 101 118 35 24 26 32 22 14 0 0.0928 1.000 1.000 393 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(27), AXIN1(11), BTRC(1), CCND1(4), CREBBP(39), CSNK1A1(1), CSNK1D(1), CSNK2A1(7), CTBP1(2), CTNNB1(6), DVL1(7), FZD1(6), GSK3B(3), HDAC1(1), MAP3K7(8), MYC(6), NLK(1), PPARD(1), TLE1(8), WIF1(1), WNT1(2) 22357252 143 100 138 36 18 34 36 24 29 2 0.0564 1.000 1.000 394 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ACY3(3), ALDH1A3(1), ALDH1B1(4), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH3B1(3), ALDH3B2(4), ALDH7A1(2), ALDH9A1(3), AMDHD1(3), AOC2(5), AOC3(5), ASPA(4), CARM1(5), CNDP1(9), DDC(7), FTCD(2), HAL(6), HARS(1), HARS2(3), HDC(4), HEMK1(1), HNMT(1), LCMT1(2), LCMT2(7), MAOA(1), MAOB(1), METTL2B(4), METTL6(3), PRMT2(1), PRMT3(6), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(4), PRPS1(3), PRPS2(2), UROC1(4) 30069281 126 99 126 37 22 34 39 17 14 0 0.0628 1.000 1.000 395 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(4), AADAC(5), ABAT(6), ACADS(2), ACAT2(2), ACSM1(6), AKR1B10(4), ALDH1A3(1), ALDH1B1(4), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH5A1(1), ALDH7A1(2), ALDH9A1(3), BDH1(1), BDH2(1), DDHD1(5), ECHS1(2), EHHADH(5), GAD1(4), GAD2(7), HADH(4), HADHA(3), HMGCL(1), HMGCS1(3), HMGCS2(2), HSD17B10(1), HSD17B4(5), HSD3B7(2), ILVBL(6), L2HGDH(4), OXCT1(2), OXCT2(1), PDHA1(4), PDHA2(14), PDHB(1), PLA1A(8), PRDX6(1), RDH11(2), RDH12(4) 30830480 137 99 137 55 17 38 42 25 15 0 0.754 1.000 1.000 396 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1A(5), ADRA1B(3), ADRA1D(3), ADRA2C(3), ADRB1(3), ADRB3(2), CHRM2(5), CHRM3(9), CHRM4(2), CHRM5(3), DRD1(2), DRD2(4), DRD3(6), DRD4(1), DRD5(8), HRH1(1), HRH2(3), HTR1A(9), HTR1B(7), HTR1D(2), HTR1E(8), HTR1F(4), HTR2A(5), HTR2B(2), HTR2C(3), HTR4(2), HTR5A(8), HTR6(6), HTR7(7) 19574300 126 99 126 61 34 17 39 21 15 0 0.747 1.000 1.000 397 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(2), B4GALT1(1), B4GALT2(5), FBP2(1), G6PC(2), GAA(3), GALK1(1), GALK2(2), GALT(2), GANAB(3), GCK(4), GLA(3), GLB1(5), HK1(4), HK2(5), HK3(8), LALBA(1), LCT(17), MGAM(32), PFKM(6), PFKP(6), PGM1(5), PGM3(1) 24702425 119 98 118 28 20 28 33 16 21 1 0.0153 1.000 1.000 398 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(6), ACAA2(1), ACADM(3), ACADS(2), ACAT2(2), ALDH1A3(1), ALDH1B1(4), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH6A1(2), ALDH7A1(2), ALDH9A1(3), AOX1(10), AUH(1), BCAT1(4), BCAT2(4), BCKDHA(3), BCKDHB(4), DBT(7), DLD(1), ECHS1(2), EHHADH(5), HADH(4), HADHA(3), HADHB(4), HIBADH(1), HIBCH(2), HMGCL(1), HMGCS1(3), HMGCS2(2), HSD17B10(1), HSD17B4(5), IVD(5), MCCC1(2), MCCC2(4), MUT(5), OXCT1(2), OXCT2(1), PCCA(9), PCCB(1) 32713574 126 98 125 44 16 33 32 27 18 0 0.608 1.000 1.000 399 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(2), CDC7(1), CDT1(1), DIAPH2(10), GMNN(3), MCM10(6), MCM2(4), MCM3(4), MCM4(7), MCM5(2), MCM6(4), MCM7(9), NACA(25), PCNA(1), POLA2(2), POLD1(11), POLD2(1), POLD3(4), POLE(11), POLE2(1), PRIM1(3), RFC1(3), RFC2(3), RFC3(2), RFC4(4), RFC5(2), RPA1(5), RPA2(1), RPA4(1), RPS27A(1), UBA52(3), UBB(1), UBC(5) 38518834 143 97 142 50 15 38 48 18 23 1 0.774 1.000 1.000 400 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(8), ADRBK2(5), ARRB2(1), CALM1(1), CALM2(2), CALM3(2), CALML3(1), CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), CLCA1(5), CLCA2(6), CLCA4(6), CNGA3(10), CNGA4(5), CNGB1(13), GNAL(4), GUCA1C(1), PDC(2), PDE1C(14), PRKACA(4), PRKACB(3), PRKACG(3), PRKG1(8), PRKG2(2), PRKX(1) 23203428 118 97 118 46 18 26 35 23 16 0 0.630 1.000 1.000 401 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(3), ACTG2(5), ADCY3(8), ADCY9(9), AK1(1), ARF4(1), ARF6(2), ARL4D(1), ATP6V0A1(4), ATP6V0A2(3), ATP6V0A4(6), ATP6V0B(1), ATP6V0C(1), ATP6V0D1(2), ATP6V0D2(3), ATP6V1A(2), ATP6V1C1(4), ATP6V1C2(3), ATP6V1D(2), ATP6V1E1(2), ATP6V1E2(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(3), ATP6V1H(3), ERO1L(3), GNAS(12), PDIA4(1), PLCG1(8), PLCG2(9), PRKCA(7), SEC61A1(4), SEC61A2(4), SEC61B(1), TRIM23(6) 28098922 127 97 127 36 24 28 36 21 18 0 0.0799 1.000 1.000 402 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 ATM(16), BMPR1B(4), CCND2(2), CDK4(5), CDKN1B(2), CEBPB(1), DAZL(3), DMC1(2), EGR1(4), ESR2(1), FSHR(12), GJA4(1), INHA(2), LHCGR(9), MLH1(5), MSH5(3), NCOR1(21), NRIP1(9), PGR(5), PRLR(8), PTGER2(5), VDR(2), ZP2(6) 26643751 128 96 124 37 14 32 39 22 21 0 0.232 1.000 1.000 403 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(2), ATF1(3), CDC42(3), CREB1(1), CREB5(8), DUSP1(2), DUSP10(3), EEF2K(6), EIF4E(1), ELK1(2), GADD45A(1), IL1R1(4), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAP3K10(6), MAP3K4(14), MAP3K5(6), MAP3K7(8), MAPK1(9), MAPK11(3), MAPK12(3), MAPK13(3), MAPK14(2), MAPKAPK5(2), MKNK1(1), MKNK2(2), MYEF2(7), NFKB1(5), NR2C2(1), SRF(1), TRAF6(3) 25354134 119 96 110 34 23 25 32 22 17 0 0.171 1.000 1.000 404 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(6), ACACA(15), ACACB(20), ACADM(3), ACAT2(2), ACSS1(5), ACSS2(2), ALDH1A3(1), ALDH1B1(4), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH6A1(2), ALDH7A1(2), ALDH9A1(3), ECHS1(2), EHHADH(5), HADHA(3), HIBCH(2), LDHA(1), LDHAL6A(2), LDHAL6B(6), LDHB(1), LDHC(4), MLYCD(3), MUT(5), PCCA(9), PCCB(1), SUCLA2(1), SUCLG1(1), SUCLG2(4) 30167579 119 93 119 45 23 22 34 23 17 0 0.777 1.000 1.000 405 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(21), CD3D(1), CD4(1), CREBBP(39), CSK(1), GNAS(12), GNB1(3), HLA-DRA(1), HLA-DRB1(2), LCK(5), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PTPRC(19), ZAP70(2) 17491281 123 92 120 39 23 25 31 20 23 1 0.269 1.000 1.000 406 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(21), CD3D(1), CD4(1), CREBBP(39), CSK(1), GNAS(12), GNB1(3), HLA-DRA(1), HLA-DRB1(2), LCK(5), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PTPRC(19), ZAP70(2) 17491281 123 92 120 39 23 25 31 20 23 1 0.269 1.000 1.000 407 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(7), CALCR(4), CALCRL(5), CD97(5), CRHR1(3), CRHR2(4), ELTD1(11), EMR1(7), EMR2(2), GHRHR(4), GIPR(2), GLP1R(2), GLP2R(3), GPR64(6), LPHN1(11), LPHN2(11), LPHN3(24), SCTR(2), VIPR1(1), VIPR2(6) 20246798 120 92 120 43 15 15 36 38 16 0 0.584 1.000 1.000 408 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM1(1), CALM2(2), CALM3(2), DLG4(3), GRIN1(4), GRIN2A(21), GRIN2B(23), GRIN2C(7), GRIN2D(6), NOS1(9), PPP3CA(2), PPP3CB(1), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), PRKCA(7), SYT1(8) 19451476 112 92 112 41 22 27 30 20 13 0 0.255 1.000 1.000 409 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CD14(1), CHUK(6), ELK1(2), FOS(6), IKBKB(12), IRAK1(3), JUN(1), LY96(2), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAP3K1(6), MAP3K7(8), MAPK14(2), MAPK8(4), NFKB1(5), NFKBIA(1), PPARA(2), RELA(2), TIRAP(1), TLR10(4), TLR2(3), TLR3(2), TLR4(16), TLR6(4), TLR7(8), TLR9(3), TOLLIP(2), TRAF6(3) 27776437 116 91 115 47 18 25 38 14 21 0 0.819 1.000 1.000 410 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP1(1), ACP2(2), ACP5(2), ACPP(2), ACPT(2), ALPI(3), ALPL(4), ALPP(3), ALPPL2(7), CYP19A1(3), CYP1A1(2), CYP1A2(5), CYP2A13(4), CYP2A6(2), CYP2A7(4), CYP2B6(5), CYP2C18(3), CYP2C19(6), CYP2C8(6), CYP2C9(7), CYP2D6(5), CYP2E1(6), CYP2F1(2), CYP2J2(7), CYP3A4(6), CYP3A5(1), CYP3A7(1), CYP4B1(3), CYP51A1(1), PON1(7) 22321126 112 90 112 44 15 18 42 21 15 1 0.782 1.000 1.000 411 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 AGXT(2), AGXT2(5), ALAS2(5), AMT(2), AOC2(5), AOC3(5), ATP6V0C(1), BHMT(1), CHDH(3), CHKB(1), CPT1B(4), CTH(3), DAO(2), DLD(1), DMGDH(6), GAMT(2), GARS(1), GATM(4), GCAT(5), GLDC(11), MAOA(1), MAOB(1), PLCB2(7), PLCG1(8), PLCG2(9), PSPH(2), SARDH(9), SARS(1), SHMT1(1), SHMT2(2), TARS(6) 31847778 116 90 116 47 28 20 39 19 10 0 0.702 1.000 1.000 412 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(9), ATP4B(2), ATP5O(1), ATP6AP1(2), ATP6V0A1(4), ATP6V0A4(6), ATP6V0B(1), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(3), ATP6V1C1(4), ATP6V1C2(3), ATP6V1D(2), ATP6V1E1(2), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(3), ATP6V1H(3), ATP7A(12), ATP7B(8), COX10(3), COX5A(2), COX5B(1), COX8A(1), NDUFA1(1), NDUFA5(3), NDUFB2(2), NDUFB4(1), NDUFB6(1), NDUFS1(1), NDUFS2(3), NDUFV1(3), SDHA(7), SDHB(1), SHMT1(1), UQCRC1(1), UQCRFS1(4) 28976279 111 90 109 30 16 28 33 24 10 0 0.0962 1.000 1.000 413 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(15), ACAT2(2), ACYP1(1), ADH5(3), AKR1B1(2), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), DLAT(4), DLD(1), GLO1(2), GRHPR(1), HAGH(1), LDHA(1), LDHB(1), LDHC(4), LDHD(1), MDH1(1), MDH2(1), ME1(2), ME2(3), ME3(7), PC(14), PCK1(1), PDHA1(4), PDHA2(14), PDHB(1), PKLR(3) 28074114 113 89 113 40 21 23 32 22 15 0 0.637 1.000 1.000 414 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 ATF1(3), BAD(1), BRAF(10), CREB1(1), CREB5(8), DUSP4(1), DUSP6(5), DUSP9(1), EEF2K(6), EIF4E(1), MAP2K1(5), MAP2K2(6), MAP3K8(4), MAPK1(9), MKNK1(1), MKNK2(2), MOS(7), NFKB1(5), RPS6KA1(10), RPS6KA2(6), RPS6KA3(4), SHC1(3), SOS1(9), SOS2(11), TRAF3(6) 22423570 125 89 117 29 33 23 35 20 14 0 0.0232 1.000 1.000 415 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 AGMAT(1), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), AMD1(4), AOC2(5), AOC3(5), ARG1(1), ARG2(1), ASL(2), CKB(4), CKM(3), CKMT1B(2), CPS1(13), DAO(2), GAMT(2), GATM(4), GLUD1(4), GOT1(1), GOT2(3), MAOA(1), MAOB(1), NOS1(9), NOS3(4), OAT(1), ODC1(3), OTC(2), P4HA1(3), P4HA2(3), P4HA3(1), P4HB(1), PYCR1(1), RARS(1), SMS(3) 33577243 114 88 114 40 22 25 30 21 16 0 0.467 1.000 1.000 416 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA2(1), ACADL(4), ACADM(3), ACADS(2), ACADSB(3), ACAT2(2), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH6A1(2), ALDH9A1(3), AOX1(10), BCAT1(4), BCKDHA(3), BCKDHB(4), ECHS1(2), EHHADH(5), HADHA(3), HADHB(4), HIBADH(1), HMGCL(1), IVD(5), MCCC1(2), MCCC2(4), MUT(5), OXCT1(2), PCCA(9), PCCB(1), SDS(1) 27373833 106 88 105 35 11 22 30 25 18 0 0.640 1.000 1.000 417 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(6), ACADL(4), ACADM(3), ACADSB(3), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), AOC2(5), AOC3(5), CNDP1(9), DPYD(16), DPYS(7), ECHS1(2), EHHADH(5), GAD1(4), GAD2(7), HADHA(3), MLYCD(3), SDS(1), SMS(3), UPB1(2) 22098133 111 87 111 32 12 30 36 22 11 0 0.198 1.000 1.000 418 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(6), ALDH5A1(1), CAD(5), CPS1(13), EARS2(4), EPRS(4), GAD1(4), GAD2(7), GCLC(4), GCLM(1), GFPT1(3), GFPT2(5), GLS(1), GLS2(2), GLUD1(4), GLUD2(10), GLUL(3), GMPS(7), GNPNAT1(1), GOT1(1), GOT2(3), GPT(1), GPT2(3), GSS(3), NADSYN1(2), PPAT(3), QARS(5) 30042916 106 87 106 51 18 24 26 20 18 0 0.954 1.000 1.000 419 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(3), CS(2), DLAT(4), DLD(1), DLST(6), FH(3), IDH2(1), IDH3A(1), IDH3B(1), IDH3G(1), MDH1(1), MDH2(1), OGDH(10), PC(14), PDHA1(4), PDHA2(14), PDHB(1), PDHX(4), PDK1(3), PDK2(1), PDK3(3), PDK4(8), SDHA(7), SDHB(1), SDHC(1), SUCLA2(1), SUCLG1(1), SUCLG2(4) 21552481 102 86 101 29 12 24 35 17 14 0 0.202 1.000 1.000 420 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AADAT(3), AASDH(5), AASDHPPT(3), AASS(3), ACAT2(2), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), ATP6V0C(1), BBOX1(1), DLST(6), DOT1L(9), ECHS1(2), EHHADH(5), EHMT1(7), EHMT2(11), GCDH(2), HADHA(3), PLOD1(3), PLOD2(7), PLOD3(4), SDS(1), SHMT1(1), SHMT2(2), TMLHE(2) 28166869 106 85 106 47 19 18 25 23 21 0 0.887 1.000 1.000 421 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(6), ACACA(15), ACADL(4), ACADM(3), ACADSB(3), ACAT2(2), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH6A1(2), ALDH9A1(3), ECHS1(2), EHHADH(5), HADHA(3), LDHA(1), LDHB(1), LDHC(4), MLYCD(3), MUT(5), PCCA(9), PCCB(1), SDS(1), SUCLA2(1), SUCLG1(1), SUCLG2(4) 25172960 99 85 99 32 17 17 31 19 15 0 0.585 1.000 1.000 422 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 ERCC3(5), GTF2A2(1), GTF2B(1), GTF2E1(7), GTF2F2(3), GTF2H1(3), GTF2H4(3), ILK(4), MNAT1(1), POLR1A(10), POLR1B(4), POLR2A(11), POLR2B(10), POLR2C(1), POLR2E(1), POLR2F(3), POLR2G(4), POLR2H(1), POLR2I(1), POLR2J(2), POLR3B(4), POLR3D(3), POLR3E(5), POLR3H(1), TAF13(1), TAF5(7), TAF6(5), TAF7(2), TAF9(3), TBP(2) 26651829 109 85 109 39 8 25 27 22 27 0 0.681 1.000 1.000 423 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ADH1A(2), ADH1B(2), ADH4(3), ADH6(1), ADH7(2), ADHFE1(4), ALDH1A3(1), ALDH3A1(1), ALDH3B1(3), ALDH3B2(4), AOC2(5), AOC3(5), AOX1(10), COMT(1), DBH(8), DCT(4), DDC(7), FAH(2), GOT1(1), GOT2(3), GSTZ1(1), HGD(4), HPD(3), MAOA(1), MAOB(1), PNMT(1), TAT(1), TH(3), TPO(11), TYR(8) 24089511 103 85 102 39 17 25 31 11 19 0 0.494 1.000 1.000 424 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 AKR1B1(2), GUSB(5), RPE(1), UGDH(4), UGP2(2), UGT1A1(4), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A9(1), UGT2A1(6), UGT2A3(7), UGT2B10(11), UGT2B11(9), UGT2B15(4), UGT2B17(5), UGT2B28(6), UGT2B4(13), UGT2B7(7), XYLB(3) 20775690 103 84 103 41 14 15 39 25 10 0 0.911 1.000 1.000 425 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 AGXT(2), AGXT2(5), AKR1B10(4), ALAS2(5), AMT(2), AOC2(5), AOC3(5), BHMT(1), CHDH(3), CHKB(1), CTH(3), DAO(2), DLD(1), DMGDH(6), GAMT(2), GARS(1), GATM(4), GCAT(5), GLDC(11), HSD3B7(2), MAOA(1), MAOB(1), PHGDH(1), PIPOX(2), PSAT1(1), PSPH(2), RDH11(2), RDH12(4), SARDH(9), SARS(1), SDS(1), SHMT1(1), SHMT2(2), TARS(6), TARS2(4) 32368566 108 84 108 44 27 20 38 15 7 1 0.682 1.000 1.000 426 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 ARSB(2), FUCA1(1), FUCA2(1), GALNS(1), GBA(3), GLB1(5), GNS(3), GUSB(5), HEXA(4), HGSNAT(3), HPSE(4), HPSE2(4), HYAL1(2), HYAL2(2), IDS(7), IDUA(6), LCT(17), MAN2B1(4), MAN2B2(3), MAN2C1(4), MANBA(4), NAGLU(4), NEU1(2), NEU2(2), NEU3(1), NEU4(2), SPAM1(3) 26180325 99 84 99 44 23 20 20 17 19 0 0.801 1.000 1.000 427 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(2), AP2A1(3), AP2M1(3), BAD(1), BTK(8), EEA1(11), GRASP(1), GSK3A(2), GSK3B(3), LYN(8), PDPK1(4), PFKL(6), PFKM(6), PFKP(6), PLCG1(8), PRKCE(3), PRKCZ(3), RAB5A(3), RAC1(15), RPS6KB1(5), VAV2(4) 19026716 105 84 97 29 18 21 31 16 18 1 0.127 1.000 1.000 428 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CALM1(1), CALM2(2), CALM3(2), CHUK(6), EGR2(5), MAP3K1(6), MYC(6), NFATC1(9), NFATC2(15), NFKB1(5), NFKBIA(1), PLCG1(8), PPP3CA(2), PPP3CB(1), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), RELA(2), SYT1(8), VIP(1), VIPR2(6) 21280054 102 83 100 37 23 20 31 16 12 0 0.444 1.000 1.000 429 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(3), CAMK2B(3), CAMK2D(3), CAMK2G(2), DAG1(5), ITPKB(5), ITPR1(16), ITPR2(25), ITPR3(10), NFAT5(13), PDE6A(3), PDE6B(2), PDE6C(3), SLC6A13(4), TF(5) 27079943 102 81 102 40 10 36 27 16 13 0 0.533 1.000 1.000 430 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(16), APOA4(4), APOC1(1), CETP(2), CYP7A1(6), DGAT1(1), HMGCR(4), LCAT(2), LDLR(5), LIPC(5), LPL(4), LRP1(34), SCARB1(1), SOAT1(5) 20853162 90 81 89 27 12 21 26 18 13 0 0.252 1.000 1.000 431 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(3), AGT(4), AGTR1(14), AGTR2(2), CMA1(5), COL4A1(10), COL4A2(9), COL4A3(19), COL4A4(14), COL4A5(14), COL4A6(4), REN(3) 19141541 101 80 100 40 12 31 29 18 11 0 0.871 1.000 1.000 432 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(6), ACADM(3), ALDH1A3(1), ALDH1B1(4), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), ALDH9A1(3), AOC2(5), AOC3(5), CNDP1(9), DPYD(16), DPYS(7), ECHS1(2), EHHADH(5), GAD1(4), GAD2(7), HADHA(3), HIBCH(2), MLYCD(3), SMS(3), UPB1(2) 20536304 96 80 96 30 11 30 29 19 7 0 0.258 1.000 1.000 433 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(4), ALG10(7), ALG10B(3), ALG11(3), ALG12(5), ALG13(4), ALG2(2), ALG3(1), ALG5(2), ALG6(4), ALG8(1), B4GALT1(1), B4GALT2(5), B4GALT3(1), DDOST(1), DHDDS(3), DOLPP1(2), DPAGT1(1), DPM1(2), FUT8(2), GANAB(3), MAN1A1(2), MAN1A2(1), MAN1B1(4), MAN1C1(3), MAN2A1(4), MGAT1(4), MGAT2(2), MGAT3(5), MGAT4A(1), MGAT4B(3), MGAT5(4), MGAT5B(5), RFT1(1), RPN1(2), RPN2(6), ST6GAL1(3), STT3B(2) 32231042 109 80 109 42 14 22 36 17 20 0 0.775 1.000 1.000 434 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 B3GNT6(2), B4GALT5(3), C1GALT1(4), C1GALT1C1(3), GALNT1(2), GALNT10(5), GALNT11(4), GALNT12(4), GALNT13(10), GALNT14(6), GALNT2(7), GALNT3(6), GALNT4(3), GALNT5(5), GALNT6(4), GALNT7(3), GALNT8(6), GALNTL5(5), GCNT1(1), GCNT3(1), GCNT4(3), OGT(4), ST3GAL1(2), ST3GAL2(1), ST6GALNAC1(4), WBSCR17(9) 24558538 107 80 107 37 17 28 30 15 16 1 0.537 1.000 1.000 435 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(8), ACE2(3), AGT(4), AGTR1(14), AGTR2(2), CMA1(5), CPA3(7), CTSA(1), CTSG(1), ENPEP(14), LNPEP(5), MAS1(2), MME(16), NLN(10), REN(3), THOP1(1) 16088430 96 80 96 33 13 18 33 20 12 0 0.458 1.000 1.000 436 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(8), DLG4(3), EPHB2(3), F2(3), F2RL1(1), F2RL2(2), F2RL3(3), JUN(1), MAP2K5(3), MAPK1(9), MAPK7(6), MAPK8(4), MYEF2(7), PLD1(15), PLD2(1), PLD3(2), PTK2(8), RAF1(3), RASAL1(5), TEC(2), VAV1(8) 20902749 97 80 90 26 13 20 26 16 21 1 0.136 1.000 1.000 437 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 ALOX12(3), ALOX5(5), CBR3(1), CYP4F2(7), CYP4F3(3), EPX(10), GGT1(4), LTA4H(1), MPO(8), PLA2G1B(2), PLA2G2A(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PRDX2(2), PRDX6(1), PTGDS(2), PTGES2(1), PTGIS(7), PTGS1(7), PTGS2(4), TBXAS1(5), TPO(11) 21251910 95 78 94 47 22 17 27 10 19 0 0.898 1.000 1.000 438 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(6), IKBKB(12), IL1A(1), IL1B(1), IL1R1(4), IL1RAP(6), IL6(2), IRAK1(3), IRAK2(2), IRAK3(9), JUN(1), MAP2K3(4), MAP2K6(1), MAP3K1(6), MAP3K7(8), MAPK14(2), MAPK8(4), NFKB1(5), NFKBIA(1), RELA(2), TGFB1(1), TGFB2(3), TGFB3(1), TOLLIP(2), TRAF6(3) 22629746 90 77 89 32 18 17 25 12 18 0 0.640 1.000 1.000 439 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(4), ACO1(7), ACO2(3), CLYBL(1), CS(2), DLD(1), DLST(6), FH(3), IDH1(4), IDH2(1), IDH3A(1), IDH3B(1), IDH3G(1), MDH1(1), MDH2(1), OGDH(10), OGDHL(12), PC(14), PCK1(1), PCK2(4), SDHA(7), SDHB(1), SDHC(1), SUCLA2(1), SUCLG1(1), SUCLG2(4) 22686178 93 76 92 36 18 18 29 15 13 0 0.618 1.000 1.000 440 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSA(1), ARSD(4), ARSE(2), ASAH1(1), B4GALT6(2), CERK(3), DEGS1(1), DEGS2(1), ENPP7(5), GAL3ST1(3), GALC(2), GBA(3), GLA(3), GLB1(5), LCT(17), NEU1(2), NEU2(2), NEU3(1), NEU4(2), PPAP2A(1), PPAP2B(1), SGMS1(2), SGMS2(1), SGPP1(5), SGPP2(2), SMPD3(2), SMPD4(5), SPHK2(3), SPTLC1(5), SPTLC2(3), UGCG(1) 27239418 91 76 91 43 19 22 25 12 13 0 0.764 1.000 1.000 441 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(3), ABAT(6), ADSL(5), ADSS(4), AGXT(2), AGXT2(5), ASL(2), ASNS(5), ASPA(4), CAD(5), CRAT(6), DARS(5), DDO(1), GAD1(4), GAD2(7), GOT1(1), GOT2(3), GPT(1), GPT2(3), NARS(2), PC(14) 19803813 88 75 88 28 15 17 30 14 12 0 0.322 1.000 1.000 442 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOA(1), ALDOB(5), ALDOC(4), FBP2(1), G6PD(4), GPI(3), H6PD(2), PFKL(6), PFKM(6), PFKP(6), PGD(2), PGM1(5), PGM3(1), PRPS1(3), PRPS1L1(5), PRPS2(2), RBKS(3), RPE(1), RPIA(3), TALDO1(5), TKT(3), TKTL1(6), TKTL2(8) 18450820 85 75 85 31 14 16 25 19 11 0 0.491 1.000 1.000 443 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ARG1(1), ARG2(1), ASL(2), ASS1(2), CKB(4), CKM(3), CKMT1B(2), CPS1(13), DAO(2), EPRS(4), GAMT(2), GATM(4), GLUD1(4), GLUD2(10), GOT1(1), GOT2(3), LAP3(2), NOS1(9), NOS3(4), OAT(1), OTC(2), P4HA1(3), P4HA2(3), P4HA3(1), PARS2(5), PRODH(1), PYCR1(1), RARS(1), RARS2(3) 27312081 94 75 94 33 20 17 22 22 13 0 0.544 1.000 1.000 444 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(6), ALDH5A1(1), CAD(5), CPS1(13), EPRS(4), GAD1(4), GAD2(7), GCLC(4), GCLM(1), GFPT1(3), GLS(1), GLS2(2), GLUD1(4), GLUL(3), GMPS(7), GOT1(1), GOT2(3), GPT(1), GPT2(3), GSS(3), NADSYN1(2), PPAT(3), QARS(5) 25243521 86 74 86 41 13 21 21 17 14 0 0.941 1.000 1.000 445 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(5), GTF2A1(3), GTF2B(1), GTF2E1(7), GTF2F1(4), HDAC3(3), NCOA1(7), NCOA2(8), NCOA3(8), NCOR2(24), POLR2A(11), RARA(4), RXRA(5), TBP(2) 18982669 92 74 92 26 12 21 25 23 11 0 0.158 1.000 1.000 446 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1C4(3), AKR1D1(3), ARSB(2), ARSD(4), ARSE(2), CYP11B1(6), CYP11B2(4), HSD11B2(3), HSD17B2(2), HSD17B3(2), HSD17B8(3), HSD3B1(4), HSD3B2(4), STS(3), SULT1E1(5), SULT2A1(2), UGT1A1(4), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A9(1), UGT2B15(4), UGT2B4(13) 20760596 87 72 87 35 18 14 27 19 9 0 0.767 1.000 1.000 447 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA2(1), ACAD8(4), ACAD9(2), ADH1A(2), ADH1B(2), ADH4(3), ADH5(3), ADH6(1), ADH7(2), ADHFE1(4), AKR1B10(4), AKR1C4(3), AKR1D1(3), ALDH1A3(1), ALDH1B1(4), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), ALDH9A1(3), BAAT(2), CEL(2), CYP27A1(3), CYP7A1(6), HADHB(4), HSD3B7(2), LIPA(3), RDH11(2), RDH12(4), SLC27A5(4), SOAT1(5), SOAT2(2) 24044556 87 72 87 38 17 20 26 16 8 0 0.839 1.000 1.000 448 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(4), ABAT(6), ACADS(2), ACAT2(2), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH5A1(1), ALDH9A1(3), ECHS1(2), EHHADH(5), GAD1(4), GAD2(7), HADHA(3), HMGCL(1), L2HGDH(4), OXCT1(2), PDHA1(4), PDHA2(14), PDHB(1), SDHB(1), SDS(1) 19612415 87 71 87 33 10 26 25 12 14 0 0.676 1.000 1.000 449 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(2), ALDOA(1), ALDOB(5), ALDOC(4), FBP2(1), FPGT(5), GCK(4), GMDS(5), GMPPA(1), HK1(4), HK2(5), HK3(8), KHK(3), MPI(5), PFKFB1(3), PFKFB3(2), PFKFB4(1), PFKM(6), PFKP(6), PMM2(2), SORD(2), TPI1(4) 18131556 79 71 79 22 14 22 18 14 11 0 0.0594 1.000 1.000 450 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 CHUK(6), FADD(4), IKBKB(12), IL1A(1), IL1R1(4), IRAK1(3), MAP3K1(6), MAP3K7(8), NFKB1(5), NFKBIA(1), RELA(2), RIPK1(2), TLR4(16), TNFAIP3(6), TNFRSF1A(1), TNFRSF1B(2), TRADD(1), TRAF6(3) 18588574 83 71 82 29 15 17 26 13 12 0 0.506 1.000 1.000 451 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(4), ALOX5(5), CYP1A2(5), CYP2C18(3), CYP2C19(6), CYP2C8(6), CYP2C9(7), CYP2E1(6), CYP2J2(7), CYP3A4(6), CYP3A43(2), CYP3A5(1), CYP3A7(1), HSD3B7(2), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), RDH11(2), RDH12(4) 18172097 84 70 84 31 11 15 36 12 9 1 0.584 1.000 1.000 452 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 AMT(2), ASNS(5), ASRGL1(1), CA1(1), CA12(2), CA14(3), CA2(1), CA3(5), CA4(5), CA5A(1), CA5B(1), CA6(3), CA7(1), CA8(5), CA9(1), CPS1(13), CTH(3), GLS(1), GLS2(2), GLUD1(4), GLUD2(10), GLUL(3), HAL(6) 16146378 79 70 79 33 16 17 21 16 9 0 0.834 1.000 1.000 453 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(17), AP2A1(3), AP2M1(3), BIN1(4), CALM1(1), CALM2(2), CALM3(2), DNM1(2), EPN1(5), EPS15(7), NME2(1), PICALM(4), PPP3CA(2), PPP3CB(1), SYNJ1(9), SYNJ2(9), SYT1(8) 16499519 80 70 80 34 10 15 27 15 13 0 0.909 1.000 1.000 454 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(3), CHIA(6), CHIT1(4), CTBS(3), CYB5R1(1), CYB5R3(6), GFPT1(3), GFPT2(5), GNE(2), GNPDA1(2), GNPNAT1(1), HEXA(4), HK1(4), HK2(5), HK3(8), LHPP(1), MTMR1(1), MTMR2(5), MTMR6(4), NANS(2), PGM3(1), PHPT1(1), RENBP(5), UAP1(4) 21800018 81 69 81 27 20 16 21 8 16 0 0.357 1.000 1.000 455 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(10), ARHGEF1(9), GNA12(1), GNA13(2), GNB1(3), MYLK(8), PLCB1(21), PPP1R12B(4), PRKCA(7), ROCK1(19) 15718096 84 69 83 30 14 16 28 15 11 0 0.695 1.000 1.000 456 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(10), COL4A2(9), COL4A3(19), COL4A4(14), COL4A5(14), COL4A6(4), P4HB(1), SLC23A1(3), SLC23A2(7), SLC2A1(4), SLC2A3(2) 18991315 87 69 86 40 10 27 23 15 12 0 0.959 1.000 1.000 457 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(3), CARS(4), DARS(5), EPRS(4), FARS2(4), GARS(1), HARS(1), IARS(11), KARS(3), LARS(5), LARS2(2), MARS(2), MARS2(5), NARS(2), QARS(5), RARS(1), SARS(1), TARS(6), WARS(2), WARS2(8), YARS(7) 24299185 82 67 82 21 6 14 33 20 9 0 0.266 1.000 1.000 458 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(3), CSF1R(2), EGF(9), EGFR(19), MET(4), PDGFRA(14), PRKCA(7), SH3GLB1(2), SH3GLB2(3), SH3KBP1(8) 14746309 71 67 71 21 9 15 23 12 11 1 0.248 1.000 1.000 459 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CDK5(3), CDK5R1(1), CSNK1D(1), DRD1(2), DRD2(4), GRM1(29), PLCB1(21), PPP1CA(1), PPP1R1B(2), PPP3CA(2), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3) 12136445 82 67 80 30 15 21 24 18 4 0 0.364 1.000 1.000 460 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH3B1(3), ALDH3B2(4), ALDH9A1(3), AOC2(5), AOC3(5), ASPA(4), CNDP1(9), DDC(7), HAL(6), HARS(1), HDC(4), HNMT(1), MAOA(1), MAOB(1), PRPS1(3), PRPS2(2) 18542350 79 67 79 25 11 18 28 12 10 0 0.278 1.000 1.000 461 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ACY1(3), AGMAT(1), ALDH18A1(2), ALDH1A3(1), ALDH1B1(4), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), ALDH9A1(3), AMD1(4), AOC2(5), AOC3(5), ARG1(1), ARG2(1), ASL(2), ASS1(2), CPS1(13), GATM(4), MAOA(1), MAOB(1), NAGS(3), ODC1(3), OTC(2), SAT1(4), SAT2(2), SMS(3) 22360443 76 66 76 26 17 21 19 11 8 0 0.349 1.000 1.000 462 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCL3(1), CCR1(1), CCR2(4), CCR3(6), CCR4(4), CCR7(2), CD28(3), CD4(1), CXCR3(1), CXCR4(2), IFNG(2), IFNGR1(4), IFNGR2(5), IL12A(1), IL12B(4), IL12RB1(4), IL12RB2(11), IL18R1(3), IL2(2), IL4(1), IL4R(8), IL5(2), TGFB1(1), TGFB2(3), TGFB3(1) 15203829 77 64 76 26 10 13 24 14 16 0 0.387 1.000 1.000 463 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 CALM1(1), CALM2(2), CALM3(2), MARCKS(1), NFATC1(9), NFATC2(15), NFATC3(6), NFATC4(3), PLCG1(8), PPP3CA(2), PPP3CB(1), PRKCA(7), SP1(3), SP3(3), SYT1(8) 15979389 71 62 71 26 14 13 22 15 7 0 0.535 1.000 1.000 464 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(4), ACTN2(11), BCAR1(3), CSK(1), CTNNA1(8), CTNNA2(29), CTNNB1(6), PTK2(8), PXN(2), VCL(6) 14613213 78 62 76 37 10 16 28 12 11 1 0.968 1.000 1.000 465 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(2), GALNS(1), GLB1(5), GNS(3), GUSB(5), HEXA(4), HGSNAT(3), HPSE(4), HPSE2(4), HYAL1(2), HYAL2(2), IDS(7), IDUA(6), LCT(17), NAGLU(4), SPAM1(3) 15532358 72 62 72 31 13 15 14 16 14 0 0.802 1.000 1.000 466 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(4), B4GALNT1(3), GLB1(5), HEXA(4), LCT(17), SLC33A1(2), ST3GAL1(2), ST3GAL2(1), ST3GAL5(6), ST6GALNAC3(8), ST6GALNAC5(5), ST6GALNAC6(4), ST8SIA1(3), ST8SIA5(7) 12508670 71 62 71 23 15 14 20 11 11 0 0.269 1.000 1.000 467 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(3), ICAM1(6), ITGA4(13), ITGAL(7), ITGAM(8), ITGB1(16), ITGB2(4), SELE(7), SELL(2), SELP(15) 12108439 81 62 80 29 9 18 21 12 21 0 0.540 1.000 1.000 468 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(2), ASNS(5), CA1(1), CA12(2), CA14(3), CA2(1), CA3(5), CA4(5), CA5A(1), CA5B(1), CA6(3), CA7(1), CA8(5), CA9(1), CPS1(13), CTH(3), GLS(1), GLS2(2), GLUD1(4), GLUL(3), HAL(6) 14444489 68 62 68 28 12 16 18 15 7 0 0.804 1.000 1.000 469 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOA(1), ALDOB(5), ALDOC(4), FBP2(1), G6PD(4), GPI(3), H6PD(2), PFKM(6), PFKP(6), PGD(2), PGM1(5), PGM3(1), PRPS1(3), PRPS1L1(5), PRPS2(2), RBKS(3), RPE(1), RPIA(3), TAL1(3), TALDO1(5), TKT(3) 15543179 68 62 68 25 11 13 19 16 9 0 0.458 1.000 1.000 470 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ALDH1A3(1), ALDH3A1(1), ALDH3B1(3), ALDH3B2(4), AOC2(5), AOC3(5), DDC(7), EPX(10), ESCO1(4), ESCO2(4), GOT1(1), GOT2(3), HPD(3), MAOA(1), MAOB(1), MPO(8), PRDX6(1), SH3GLB1(2), TAT(1), TPO(11) 26016506 76 61 75 37 15 16 27 6 12 0 0.924 1.000 1.000 471 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 ALAD(2), BLVRA(3), CP(8), CPOX(1), EPRS(4), FECH(1), GUSB(5), HCCS(2), HMOX1(1), HMOX2(1), PPOX(1), UGT1A1(4), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A9(1), UGT2B15(4), UGT2B4(13), UROD(1), UROS(4) 20864118 69 61 69 36 8 11 25 17 8 0 0.993 1.000 1.000 472 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 ATF1(3), CASP2(3), CHUK(6), CRADD(1), IKBKB(12), JUN(1), LTA(4), MAP2K3(4), MAP2K4(2), MAP2K6(1), MAP3K1(6), MAP4K2(2), MAPK14(2), MAPK8(4), NFKB1(5), NFKBIA(1), RELA(2), RIPK1(2), TANK(2), TNFRSF1A(1), TRADD(1), TRAF2(2) 18415390 67 61 67 25 13 12 21 9 12 0 0.665 1.000 1.000 473 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(9), IL13(1), IL4(1), IL5(2), JUNB(2), MAF(1), MAP2K3(4), MAPK14(2), NFATC1(9), NFATC2(15), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3) 9250727 62 60 62 26 18 13 13 9 9 0 0.414 1.000 1.000 474 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP1(1), ACP2(2), ACP5(2), ACP6(5), ACPP(2), ACPT(2), ALPI(3), ALPL(4), ALPP(3), ALPPL2(7), CMBL(2), CYP3A4(6), CYP3A43(2), CYP3A5(1), CYP3A7(1), DHRS1(2), DHRS2(4), DHRS3(1), DHRS7(1), PON1(7), PON2(1), PON3(9) 13706360 68 59 67 28 10 9 23 12 14 0 0.849 1.000 1.000 475 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(1), CARM1(5), CTH(3), GGT1(4), HEMK1(1), LCMT1(2), LCMT2(7), MARS(2), MARS2(5), MAT1A(1), METTL2B(4), METTL6(3), PAPSS1(6), PAPSS2(6), PRMT2(1), PRMT3(6), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(4), SCLY(1), SEPHS1(1), SEPHS2(3) 18938494 74 59 74 23 17 20 19 11 7 0 0.179 1.000 1.000 476 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(3), EXT2(5), EXTL1(3), EXTL2(3), EXTL3(2), GLCE(1), HS2ST1(5), HS3ST2(2), HS3ST3A1(3), HS3ST3B1(1), HS3ST5(6), HS6ST1(3), HS6ST2(1), HS6ST3(1), NDST1(1), NDST2(2), NDST3(7), NDST4(15) 15808855 64 59 64 31 14 11 23 9 7 0 0.929 1.000 1.000 477 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 CHUK(6), DUSP1(2), IKBKAP(6), IKBKB(12), LTA(4), MAP3K1(6), NFKB1(5), NFKBIA(1), RELA(2), RIPK1(2), TANK(2), TNFAIP3(6), TNFRSF1B(2), TRAF2(2), TRAF3(6) 17108010 64 59 64 22 12 14 17 7 14 0 0.448 1.000 1.000 478 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(10), BST1(2), CD38(5), ENPP1(10), ENPP3(8), NADK(2), NADSYN1(2), NMNAT1(4), NMNAT2(1), NNMT(3), NNT(6), NT5C1A(2), NT5C1B(7), NT5C2(2), NT5E(1), NUDT12(4), QPRT(1) 16385816 70 58 70 36 9 9 23 18 11 0 0.984 1.000 1.000 479 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ALDH1A3(1), ALDH3A1(1), ALDH3B1(3), ALDH3B2(4), AOC2(5), AOC3(5), DDC(7), EPX(10), GOT1(1), GOT2(3), HPD(3), MAOA(1), MAOB(1), MPO(8), PRDX2(2), PRDX6(1), TAT(1), TPO(11) 16695952 68 58 67 32 15 15 23 6 9 0 0.769 1.000 1.000 480 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 AANAT(1), ACHE(2), CHAT(9), COMT(1), DBH(8), DDC(7), GAD1(4), GAD2(7), HDC(4), MAOA(1), PAH(7), PNMT(1), SLC18A3(6), TH(3), TPH1(2) 10979411 63 57 63 28 9 13 23 5 13 0 0.766 1.000 1.000 481 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(21), CFTR(14), GNAS(12), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), SLC9A3R1(1) 9965823 64 57 63 20 18 13 18 9 6 0 0.322 1.000 1.000 482 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(21), GNAS(12), GNB1(3), PRKAA1(4), PRKAA2(4), PRKAB1(4), PRKAB2(2), PRKACB(3), PRKACG(3), PRKAG2(2), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3) 11662340 68 57 67 23 20 10 20 10 8 0 0.578 1.000 1.000 483 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(1), POLD1(11), POLD2(1), POLE(11), POLG(8), POLL(6), POLQ(22) 12728592 60 57 60 17 11 12 14 7 16 0 0.229 1.000 1.000 484 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOA(1), ALDOB(5), ALDOC(4), FBP2(1), GOT1(1), GOT2(3), GPT(1), GPT2(3), MDH1(1), MDH2(1), ME1(2), ME3(7), PGK1(2), PGK2(5), PKLR(3), RPE(1), RPIA(3), TKT(3), TKTL1(6), TKTL2(8), TPI1(4) 15364646 65 57 65 23 10 14 23 11 7 0 0.519 1.000 1.000 485 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(21), GNAS(12), PLCE1(21), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3), RAP2B(2) 11244945 72 57 71 23 20 14 21 8 9 0 0.328 1.000 1.000 486 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(4), BCAT2(4), COASY(2), DPYD(16), DPYS(7), ENPP1(10), ENPP3(8), ILVBL(6), PANK1(2), PANK2(2), PANK3(2), PANK4(1), PPCS(2), UPB1(2), VNN1(3) 13169729 71 56 71 29 8 15 23 16 9 0 0.823 1.000 1.000 487 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(30), MAP2(20), PPP1CA(1), PRKACB(3), PRKACG(3), PRKAR2B(3), PRKCE(3) 13782702 63 55 62 20 4 7 24 11 17 0 0.836 1.000 1.000 488 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CD80(5), CR1(10), CR2(8), FCGR2B(1), HLA-DRA(1), HLA-DRB1(2), ICAM1(6), ITGAL(7), ITGB2(4), PTPRC(19) 11557965 63 55 62 29 4 17 17 9 16 0 0.919 1.000 1.000 489 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT1(2), AGPAT2(3), AGPAT3(3), AGPAT4(2), AGPAT6(2), AGPS(5), CHPT1(2), ENPP2(10), ENPP6(5), PAFAH1B1(1), PAFAH1B3(1), PAFAH2(1), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PLD1(15), PLD2(1), PPAP2A(1), PPAP2B(1) 17648206 72 55 72 23 5 20 23 12 12 0 0.350 1.000 1.000 490 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSA(1), ARSB(2), ARSD(4), ARSE(2), ASAH1(1), GAL3ST1(3), GALC(2), GBA(3), GLA(3), GLB1(5), LCT(17), NEU1(2), NEU2(2), NEU3(1), NEU4(2), PPAP2A(1), PPAP2B(1), SPTLC1(5), SPTLC2(3), UGCG(1) 18358974 61 54 61 32 13 16 16 6 10 0 0.894 1.000 1.000 491 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 36 G6PD(4), GCLC(4), GCLM(1), GGT1(4), GPX2(1), GPX5(2), GPX6(4), GPX7(1), GSS(3), GSTA1(3), GSTA2(1), GSTA3(2), GSTA5(2), GSTK1(2), GSTM1(1), GSTM2(3), GSTM3(1), GSTM4(5), GSTM5(1), GSTP1(1), GSTT1(1), GSTZ1(1), IDH1(4), IDH2(1), MGST1(1), MGST2(1), MGST3(2), OPLAH(6) 16828021 63 54 63 29 11 17 17 12 6 0 0.662 1.000 1.000 492 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(5), IL22(2), IL22RA1(4), IL22RA2(1), JAK1(11), JAK2(5), JAK3(6), SOCS3(1), STAT1(7), STAT3(6), STAT5A(3), STAT5B(5), TYK2(8) 13969727 64 54 64 26 8 19 18 10 9 0 0.527 1.000 1.000 493 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(15), CPT1A(6), LEP(1), LEPR(20), PRKAA1(4), PRKAA2(4), PRKAB1(4), PRKAB2(2), PRKAG2(2) 10992549 58 54 58 30 9 8 21 8 12 0 0.990 1.000 1.000 494 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(4), F13A1(8), F2(3), F2R(4), FGA(10), FGB(4), FGG(6), PLAT(3), PLG(13), SERPINB2(2), SERPINE1(8) 10177414 65 53 65 22 5 16 18 9 17 0 0.595 1.000 1.000 495 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(1), AMD1(4), BHMT(1), CTH(3), DNMT1(11), DNMT3A(13), DNMT3B(9), MARS(2), MARS2(5), MAT1A(1), MTAP(4), MTFMT(4), MTR(8), TAT(1) 15762418 67 53 67 25 9 14 15 13 16 0 0.489 1.000 1.000 496 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(4), BCAT2(4), IARS(11), IARS2(3), ILVBL(6), LARS(5), LARS2(2), PDHA1(4), PDHA2(14), PDHB(1), VARS(6), VARS2(4) 14172257 64 53 64 23 3 24 20 7 10 0 0.571 1.000 1.000 497 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(10), POLR1B(4), POLR1C(2), POLR2A(11), POLR2B(10), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(3), POLR2G(4), POLR2H(1), POLR2I(1), POLR2J(2), POLR2L(2), POLR3A(9), POLR3B(4), POLR3G(1), POLR3GL(2), POLR3H(1) 17836859 70 53 70 21 6 16 20 13 15 0 0.351 1.000 1.000 498 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(1), CHUK(6), IFNG(2), IKBKB(12), IL2(2), IL4(1), JUN(1), MAP3K1(6), MAP3K5(6), MAP4K5(2), MAPK14(2), MAPK8(4), NFKB1(5), NFKBIA(1), RELA(2), TNFRSF9(4), TNFSF9(1), TRAF2(2) 14780390 60 52 60 20 9 9 21 7 14 0 0.624 1.000 1.000 499 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(4), ACTR2(1), ARPC1B(3), ARPC2(2), ARPC3(1), ARPC4(1), NCK1(5), NCKAP1(8), NTRK1(3), PIR(1), RAC1(15), WASF1(3), WASF2(5), WASF3(5), WASL(2) 11577433 59 52 52 22 16 14 13 12 4 0 0.683 1.000 1.000 500 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA2(1), ADH1A(2), ADH1B(2), ADH4(3), ADH6(1), ADH7(2), ADHFE1(4), AKR1C4(3), AKR1D1(3), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), BAAT(2), CEL(2), CYP27A1(3), CYP7A1(6), HADHB(4), SOAT2(2) 17667332 63 52 63 28 10 11 18 14 10 0 0.901 1.000 1.000 501 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(7), ACO2(3), CS(2), DLD(1), DLST(6), FH(3), IDH1(4), IDH2(1), IDH3A(1), IDH3B(1), IDH3G(1), MDH1(1), MDH2(1), PC(14), PCK1(1), SDHA(7), SDHB(1), SUCLA2(1), SUCLG1(1), SUCLG2(4) 15649727 61 52 60 21 10 16 18 10 7 0 0.351 1.000 1.000 502 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(11), EGF(9), EGFR(19), HGS(2), RAB5A(3), TF(5), TFRC(7) 9752921 56 52 56 21 5 12 17 11 10 1 0.810 1.000 1.000 503 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(4), ALDH1A3(1), ALDH1B1(4), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), ALDH9A1(3), CYP2C19(6), CYP2C9(7), DHRS1(2), DHRS2(4), DHRS3(1), DHRS7(1), ECHS1(2), EHHADH(5), ESCO1(4), ESCO2(4), HADHA(3), SH3GLB1(2), YOD1(4) 23523236 63 52 63 28 3 14 20 16 10 0 0.924 1.000 1.000 504 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(5), ABCC2(9), ABCG2(4), BCHE(5), CES1(7), CES2(8), CYP3A4(6), CYP3A5(1), UGT1A1(4), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A9(1) 17365735 63 52 63 35 13 10 24 8 8 0 0.964 1.000 1.000 505 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ACY1(3), ALDH18A1(2), ARG1(1), ARG2(1), ASL(2), CKB(4), CKM(3), CKMT1B(2), CPS1(13), GAMT(2), GATM(4), GLUD1(4), NAGS(3), OAT(1), ODC1(3), OTC(2), PYCR1(1), SMS(3) 13320479 54 52 54 16 15 15 13 7 4 0 0.162 1.000 1.000 506 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 CHUK(6), DUSP1(2), IKBKAP(6), IKBKB(12), MAP3K1(6), NFKB1(5), NFKBIA(1), RELA(2), TNFAIP3(6), TRAF3(6), TRAF6(3) 13818226 55 51 55 18 10 12 15 5 13 0 0.472 1.000 1.000 507 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 B3GNT1(3), B3GNT2(1), B3GNT3(5), B3GNT5(2), B4GALT1(1), B4GALT2(5), B4GALT3(1), B4GALT4(2), FUT2(2), FUT3(3), FUT5(4), FUT6(2), FUT7(1), FUT9(11), GCNT2(5), ST3GAL6(4), ST8SIA1(3) 12353169 55 51 53 16 8 15 23 5 4 0 0.165 1.000 1.000 508 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(9), AMT(2), ATIC(5), DHFR(3), FTCD(2), GART(4), MTFMT(4), MTHFD1(7), MTHFD1L(6), MTHFD2(3), MTHFR(2), MTHFS(2), MTR(8), SHMT1(1), SHMT2(2), TYMS(2) 14376024 62 51 62 25 9 6 25 9 12 1 0.845 1.000 1.000 509 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP1(1), ACP2(2), ACP5(2), ACP6(5), ACPP(2), ACPT(2), ENPP1(10), ENPP3(8), FLAD1(5), LHPP(1), MTMR1(1), MTMR2(5), MTMR6(4), PHPT1(1), TYR(8) 11427331 57 51 57 18 11 5 24 6 11 0 0.700 1.000 1.000 510 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 BET1(1), BNIP1(1), GOSR1(4), GOSR2(1), SNAP25(3), STX11(6), STX12(1), STX17(4), STX18(4), STX19(3), STX4(7), STX5(4), STX7(3), STX8(2), TSNARE1(5), USE1(1), VAMP1(3), VAMP5(1), VAMP7(1), VTI1A(1), YKT6(1) 12701549 57 51 56 17 11 13 16 4 13 0 0.291 1.000 1.000 511 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 BECN1(2), GABARAPL1(1), IFNA10(1), IFNA14(1), IFNA16(4), IFNA17(3), IFNA2(1), IFNA21(2), IFNA4(4), IFNA6(1), IFNA8(3), IFNG(2), PIK3C3(5), PIK3R4(11), PRKAA1(4), PRKAA2(4), ULK1(8), ULK2(2) 16075307 59 51 59 27 8 8 27 11 5 0 0.952 1.000 1.000 512 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CD3D(1), CXCR3(1), ETV5(5), IFNG(2), IL12A(1), IL12B(4), IL12RB1(4), IL12RB2(11), IL18(1), IL18R1(3), JAK2(5), JUN(1), MAP2K6(1), MAPK14(2), MAPK8(4), STAT4(6), TYK2(8) 14191291 60 51 60 23 5 13 18 8 16 0 0.772 1.000 1.000 513 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(3), JAK1(11), PTPRU(9), REG1A(13), STAT1(7), STAT2(5), TYK2(8) 9506297 56 50 56 22 9 14 15 7 11 0 0.593 1.000 1.000 514 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(20), ABCB11(9), ABCB4(13), ABCC1(5), ABCC3(4), GSTP1(1) 10885488 52 49 52 24 7 10 18 3 14 0 0.806 1.000 1.000 515 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 HRAS(32), MMP14(4), MMP2(5), MMP9(1), RECK(10), TIMP1(1), TIMP2(1), TIMP4(1) 5716600 55 49 32 19 9 11 23 9 3 0 0.456 1.000 1.000 516 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(2), GALNS(1), GLB1(5), GNS(3), GUSB(5), HEXA(4), IDS(7), IDUA(6), LCT(17), NAGLU(4) 10912235 54 48 54 23 11 14 12 10 7 0 0.644 1.000 1.000 517 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(15), ACACB(20), FASN(10), MCAT(3), OLAH(3), OXSM(3) 12070202 54 48 54 23 13 12 14 10 5 0 0.676 1.000 1.000 518 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(3), ICAM1(6), ITGA4(13), ITGAL(7), ITGB1(16), ITGB2(4), SELE(7), SELL(2) 9205718 58 48 57 23 7 14 13 8 16 0 0.651 1.000 1.000 519 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(9), AMT(2), ATIC(5), ATP6V0C(1), DHFR(3), GART(4), MTHFD1(7), MTHFD1L(6), MTHFD2(3), MTHFR(2), MTHFS(2), MTR(8), SHMT1(1), SHMT2(2), TYMS(2) 13581168 57 48 57 26 9 5 25 8 9 1 0.940 1.000 1.000 520 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(4), COASY(2), DPYD(16), DPYS(7), ENPP1(10), ENPP3(8), PANK1(2), PANK2(2), PANK3(2), PANK4(1), PPCS(2), UPB1(2) 10610737 58 48 58 22 7 10 19 14 8 0 0.775 1.000 1.000 521 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(6), ESR2(1), PDE1A(6), PDE1B(4), PLCB1(21), PLCB2(7), PRL(4), TRH(2), VIP(1) 8460897 52 48 51 23 6 7 24 10 5 0 0.844 1.000 1.000 522 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(2), GABRA1(11), GABRA2(13), GABRA3(7), GABRA4(5), GABRA5(6), GABRA6(6), GPHN(4), NSF(1), UBQLN1(2) 9111054 57 47 56 25 5 10 21 9 12 0 0.943 1.000 1.000 523 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CYB5R3(6), GCK(4), GFPT1(3), GNE(2), GNPDA1(2), HEXA(4), HK1(4), HK2(5), HK3(8), PGM3(1), RENBP(5), UAP1(4) 12878816 48 46 48 16 13 13 9 6 7 0 0.352 1.000 1.000 524 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 CD2(1), CD33(2), CD5(1), CD7(2), IFNG(2), IL12A(1), IL12B(4), IL13(1), IL3(1), IL4(1), IL5(2), ITGAX(7), TLR2(3), TLR4(16), TLR7(8), TLR9(3) 14151845 55 46 55 28 8 12 17 9 9 0 0.897 1.000 1.000 525 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(2), GUSB(5), RPE(1), UCHL3(1), UGDH(4), UGT1A1(4), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A9(1), UGT2B15(4), UGT2B4(13) 13372374 48 46 48 26 9 4 15 15 5 0 0.980 1.000 1.000 526 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 FUCA1(1), FUCA2(1), GLB1(5), HEXA(4), LCT(17), MAN2B1(4), MAN2B2(3), MAN2C1(4), MANBA(4), NEU1(2), NEU2(2), NEU3(1), NEU4(2) 15482055 50 45 50 25 15 8 12 6 9 0 0.825 1.000 1.000 527 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(7), ACO2(3), AFMID(6), CS(2), GRHPR(1), HAO1(12), HAO2(1), HYI(1), MDH1(1), MDH2(1), MTHFD1(7), MTHFD1L(6), MTHFD2(3) 10171935 51 45 51 16 6 13 17 8 6 1 0.483 1.000 1.000 528 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(4), ACADM(3), ACADS(2), ACADVL(4), ACSL1(3), ACSL3(3), ACSL4(6), CPT1A(6), CPT2(7), EHHADH(5), HADHA(3), SCP2(2), SLC25A20(3) 12775859 51 45 51 20 5 13 11 12 10 0 0.762 1.000 1.000 529 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(2), GALNT10(5), GALNT2(7), GALNT3(6), GALNT4(3), GALNT6(4), GALNT7(3), GALNT8(6), GCNT1(1), ST3GAL1(2), ST3GAL2(1), ST3GAL4(1), WBSCR17(9) 10976813 50 45 50 19 8 14 14 5 8 1 0.591 1.000 1.000 530 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(4), KHK(3), LCT(17), MPI(5), PGM1(5), PYGL(9), PYGM(8), TPI1(4) 10134954 55 44 55 18 10 14 15 8 8 0 0.227 1.000 1.000 531 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(11), GABRA2(13), GABRA3(7), GABRA4(5), GABRA5(6), GABRA6(6), PRKCE(3), SOD1(1) 5981221 52 44 51 19 4 7 21 8 12 0 0.805 1.000 1.000 532 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 30 G6PD(4), GCLC(4), GCLM(1), GGT1(4), GPX2(1), GPX5(2), GSS(3), GSTA1(3), GSTA2(1), GSTA3(2), GSTM1(1), GSTM2(3), GSTM3(1), GSTM4(5), GSTM5(1), GSTP1(1), GSTT1(1), GSTZ1(1), IDH1(4), IDH2(1), MGST1(1), MGST2(1), MGST3(2), PGD(2) 13740469 50 44 50 20 11 13 11 9 6 0 0.489 1.000 1.000 533 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(1), GPLD1(3), PGAP1(4), PIGA(2), PIGB(3), PIGC(2), PIGG(6), PIGK(6), PIGN(3), PIGO(4), PIGP(1), PIGQ(4), PIGS(2), PIGT(2), PIGU(1), PIGV(1), PIGW(2), PIGX(2), PIGZ(2) 18076612 51 44 51 33 8 13 15 6 9 0 0.995 1.000 1.000 534 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOA(1), ALDOB(5), ALDOC(4), FBP2(1), GOT1(1), GOT2(3), GPT(1), GPT2(3), MDH1(1), MDH2(1), ME1(2), ME2(3), ME3(7), PGK1(2), PKLR(3), RPE(1), RPIA(3), TKT(3), TPI1(4) 13746524 49 43 49 18 9 10 16 9 5 0 0.565 1.000 1.000 535 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(5), AOC2(5), AOC3(5), CES1(7), DDHD1(5), ESCO1(4), ESCO2(4), LIPA(3), PLA1A(8), PRDX6(1), SH3GLB1(2) 19292782 49 43 49 12 4 12 19 8 6 0 0.268 1.000 1.000 536 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(1), BHMT(1), CTH(3), DNMT1(11), DNMT3A(13), DNMT3B(9), MARS(2), MARS2(5), MAT1A(1), MTR(8) 13211457 54 43 54 23 8 12 13 11 10 0 0.679 1.000 1.000 537 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(10), CD38(5), ENPP1(10), ENPP3(8), NADSYN1(2), NMNAT1(4), NMNAT2(1), NNMT(3), NNT(6), NT5E(1), QPRT(1) 11070058 51 43 51 27 4 7 19 13 8 0 0.981 1.000 1.000 538 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(2), IL4(1), IL4R(8), IRS1(4), JAK1(11), JAK3(6), RPS6KB1(5), SHC1(3), STAT6(5) 11221458 45 42 45 13 7 11 12 8 7 0 0.220 1.000 1.000 539 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(1), ALG5(2), B4GALT1(1), B4GALT2(5), B4GALT3(1), B4GALT5(3), DDOST(1), DPAGT1(1), DPM1(2), FUT8(2), MAN1A1(2), MAN1B1(4), MGAT1(4), MGAT2(2), MGAT3(5), MGAT4A(1), MGAT4B(3), MGAT5(4), RPN1(2), RPN2(6), ST6GAL1(3) 15241478 55 42 55 18 9 9 15 9 13 0 0.448 1.000 1.000 540 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(5), ADSS(4), DHFR(3), HPRT1(2), IMPDH1(3), MTHFD2(3), NME2(1), OAZ1(2), POLB(1), POLD1(11), POLG(8), PRPS2(2), RRM1(1) 9527178 46 42 46 16 12 5 18 2 9 0 0.554 1.000 1.000 541 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(1), CD28(3), CD3D(1), CD8A(2), ICAM1(6), ITGAL(7), ITGB2(4), PTPRC(19), THY1(2) 8175122 45 42 45 22 4 8 10 9 14 0 0.872 1.000 1.000 542 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(7), ACO2(3), CS(2), GRHPR(1), HAO1(12), HAO2(1), HYI(1), MDH1(1), MDH2(1), MTHFD1(7), MTHFD1L(6), MTHFD2(3) 9711714 45 41 45 16 6 10 16 7 5 1 0.666 1.000 1.000 543 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(1), CD28(3), CD3D(1), CD4(1), ICAM1(6), ITGAL(7), ITGB2(4), PTPRC(19), THY1(2) 8577979 44 41 44 22 3 8 10 10 13 0 0.885 1.000 1.000 544 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(8), AGT(4), AGTR1(14), AGTR2(2), BDKRB2(3), KNG1(4), NOS3(4), REN(3) 7503265 42 40 42 17 7 12 10 8 5 0 0.509 1.000 1.000 545 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARFGAP1(3), ARFGAP3(5), ARFGEF2(14), CLTA(1), CLTB(1), COPA(7), GBF1(12), GPLD1(3) 12328265 46 40 46 14 5 16 12 4 9 0 0.253 1.000 1.000 546 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREB1(1), CREM(1), FOS(6), JUN(1), OPRK1(7), POLR2A(11), PRKACB(3), PRKACG(3), PRKAR1A(3), PRKAR1B(4), PRKAR2B(3) 9805793 43 40 43 17 9 12 11 6 5 0 0.541 1.000 1.000 547 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(9), EGFR(19), ERBB3(14), NRG1(1) 7831161 43 40 43 16 5 9 11 12 5 1 0.759 1.000 1.000 548 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT1(3), B3GNT2(1), B3GNT7(3), B4GALT1(1), B4GALT2(5), B4GALT3(1), B4GALT4(2), CHST1(4), CHST2(5), CHST4(4), CHST6(8), FUT8(2), ST3GAL1(2), ST3GAL2(1), ST3GAL3(4), ST3GAL4(1) 9584644 47 40 47 22 19 8 14 2 4 0 0.756 1.000 1.000 549 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT2(2), ACOT11(4), ACYP1(1), DHRS1(2), DHRS2(4), DHRS3(1), DHRS7(1), ECHS1(2), EHHADH(5), ESCO1(4), ESCO2(4), FN3K(3), GCDH(2), HADHA(3), SH3GLB1(2), YOD1(4) 19773448 44 40 44 16 2 11 12 11 8 0 0.675 1.000 1.000 550 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 ALDOA(1), CTSD(5), ESR1(6), GREB1(18), HSPB2(2), MTA1(8), MTA3(2), PDZK1(1), TUBA8(2) 8345615 45 40 45 21 12 3 16 8 6 0 0.832 1.000 1.000 551 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 FUCA1(1), FUCA2(1), GLB1(5), HEXA(4), LCT(17), MAN2C1(4), MANBA(4), NEU1(2), NEU2(2), NEU3(1), NEU4(2) 12562163 43 39 43 21 12 6 12 6 7 0 0.829 1.000 1.000 552 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(3), CYP51A1(1), DHCR24(1), DHCR7(1), EBP(1), FDFT1(4), FDPS(2), GGCX(5), GGPS1(1), HMGCR(4), HSD17B7(1), IDI1(1), IDI2(1), LSS(4), MVD(2), NQO1(3), NSDHL(2), PMVK(4), TM7SF2(2) 14668829 43 38 43 18 11 10 9 5 8 0 0.643 1.000 1.000 553 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(3), CAT(4), EPX(10), MPO(8), MTHFR(2), PRDX6(1), SHMT1(1), SHMT2(2), TPO(11) 8827971 42 38 41 22 15 6 15 3 3 0 0.892 1.000 1.000 554 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(4), PSMA2(1), PSMA3(2), PSMA5(1), PSMA6(2), PSMB1(1), PSMB2(1), PSMB3(1), PSMB4(2), PSMB5(3), PSMB6(1), PSMB7(1), PSMC2(6), PSMC3(2), PSMD1(6), PSMD11(1), PSMD12(1), PSMD13(1), PSMD2(6) 12149192 43 38 43 15 3 8 16 11 5 0 0.710 1.000 1.000 555 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(3), ATP6V0C(1), CAT(4), EPX(10), MPO(8), PRDX2(2), PRDX6(1), SHMT1(1), SHMT2(2), TPO(11) 8975989 43 38 42 22 14 6 15 5 3 0 0.890 1.000 1.000 556 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 MRPS7(1), RPL10A(1), RPL10L(6), RPL12(1), RPL13A(2), RPL18A(1), RPL26(1), RPL27(1), RPL28(1), RPL3(5), RPL31(2), RPL32(1), RPL37(2), RPL37A(1), RPL39(1), RPL3L(1), RPL6(3), RPL8(1), RPS10(2), RPS13(2), RPS15A(1), RPS20(1), RPS21(1), RPS23(1), RPS25(2), RPS26(1), RPS28(1), RPS3(1), RPS5(1) 17258755 46 37 46 23 5 10 18 4 9 0 0.921 1.000 1.000 557 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(2), CLOCK(6), CRY1(6), CRY2(3), CSNK1D(1), CSNK1E(6), NPAS2(2), NR1D1(1), PER1(7), PER2(2), PER3(7) 12977866 43 37 43 18 11 10 10 9 3 0 0.681 1.000 1.000 558 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(3), HMOX1(1), IL10RA(5), IL10RB(2), IL1A(1), IL6(2), JAK1(11), STAT1(7), STAT3(6), STAT5A(3) 9254119 41 37 41 19 3 15 11 6 6 0 0.579 1.000 1.000 559 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CD2(1), CD3D(1), CD4(1), CXCR3(1), IFNG(2), IL12A(1), IL12B(4), IL12RB1(4), IL12RB2(11), JAK2(5), STAT4(6), TYK2(8) 11170748 45 37 45 19 4 10 14 7 10 0 0.789 1.000 1.000 560 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP5O(1), ATP6AP1(2), ATP6V0A1(4), ATP6V0A4(6), ATP6V0B(1), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(3), ATP6V1C1(4), ATP6V1C2(3), ATP6V1D(2), ATP6V1E1(2), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(3), ATP6V1H(3), FDXR(3), SHMT1(1) 12146771 48 37 48 16 6 9 17 9 7 0 0.590 1.000 1.000 561 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP1(1), ACP2(2), ACP5(2), ACPP(2), ACPT(2), ENPP1(10), ENPP3(8), FLAD1(5), TYR(8) 7388664 40 37 40 14 5 5 19 4 7 0 0.741 1.000 1.000 562 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(8), CD44(3), CSF1(2), FCGR3A(7), IL1B(1), IL6R(5), SELL(2), SPN(3), TGFB1(1), TGFB2(3), TNFRSF1A(1), TNFRSF1B(2), TNFRSF8(2), TNFSF8(2) 10031334 42 37 42 19 6 12 10 10 4 0 0.679 1.000 1.000 563 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(6), MAPK14(2), MAPK8(4), NFKB1(5), RELA(2), TNFRSF13B(1), TNFRSF13C(2), TNFSF13(1), TNFSF13B(2), TRAF2(2), TRAF3(6), TRAF5(1), TRAF6(3) 11090459 37 37 36 13 4 9 12 1 11 0 0.598 1.000 1.000 564 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 C9orf47(1), CNR1(4), DNMT1(11), MTNR1A(3), MTNR1B(3), PTGDR(3), PTGER2(5), PTGER4(6), PTGFR(2), PTGIR(2), TBXA2R(1) 8514322 41 36 41 22 8 8 16 5 4 0 0.770 1.000 1.000 565 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(1), ATP6AP1(2), ATP6V0A1(4), ATP6V0A4(6), ATP6V0B(1), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(3), ATP6V1C1(4), ATP6V1C2(3), ATP6V1D(2), ATP6V1E1(2), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(3), ATP6V1H(3), SHMT1(1) 11410965 45 35 45 14 5 9 15 9 7 0 0.486 1.000 1.000 566 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(1), ATP6AP1(2), ATP6V0A1(4), ATP6V0A4(6), ATP6V0B(1), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(3), ATP6V1C1(4), ATP6V1C2(3), ATP6V1D(2), ATP6V1E1(2), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(3), ATP6V1H(3), SHMT1(1) 11410965 45 35 45 14 5 9 15 9 7 0 0.486 1.000 1.000 567 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS(4), CARS2(1), CDO1(2), CTH(3), GOT1(1), GOT2(3), LDHA(1), LDHAL6A(2), LDHAL6B(6), LDHB(1), LDHC(4), MPST(2), SDS(1), SULT1B1(3), SULT1C2(3), SULT1C4(2), SULT4A1(1) 9523891 40 35 40 15 8 5 15 7 5 0 0.688 1.000 1.000 568 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(4), ACAD9(2), ADH1A(2), ADH1B(2), ADH4(3), ADH5(3), ADH6(1), ADH7(2), ADHFE1(4), DHRS1(2), DHRS2(4), DHRS3(1), DHRS7(1), ESCO1(4), ESCO2(4), SH3GLB1(2) 18987938 41 35 41 16 3 12 8 8 10 0 0.754 1.000 1.000 569 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(10), MPO(8), PRDX2(2), PRDX6(1), TPO(11), TYR(8) 7343191 40 35 39 18 11 4 17 4 4 0 0.818 1.000 1.000 570 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(1), ATP6AP1(2), ATP6V0A1(4), ATP6V0A4(6), ATP6V0B(1), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(3), ATP6V1C1(4), ATP6V1C2(3), ATP6V1D(2), ATP6V1E1(2), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(3), ATP6V1H(3), SHMT1(1) 11410965 45 35 45 14 5 9 15 9 7 0 0.486 1.000 1.000 571 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(4), IARS(11), LARS(5), LARS2(2), PDHA1(4), PDHA2(14), PDHB(1) 7603533 41 35 41 13 0 16 13 6 6 0 0.622 1.000 1.000 572 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(2), CYSLTR2(5), GPR161(4), GPR171(3), GPR18(1), GPR34(1), GPR39(7), GPR45(5), GPR65(2), GPR68(2), GPR75(5) 7484334 37 34 37 19 11 6 7 7 6 0 0.887 1.000 1.000 573 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 NFKB1(5), NFKBIA(1), PLCB1(21), PRKCA(7), RELA(2) 6273776 36 34 35 12 5 6 15 6 4 0 0.519 1.000 1.000 574 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13(1), IL13RA1(2), IL13RA2(4), IL4R(8), JAK1(11), JAK2(5), TYK2(8) 7970737 39 34 39 14 8 8 9 7 7 0 0.578 1.000 1.000 575 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13(1), IL13RA1(2), IL13RA2(4), IL4R(8), JAK1(11), JAK2(5), TYK2(8) 7970737 39 34 39 14 8 8 9 7 7 0 0.578 1.000 1.000 576 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(2), CHAT(9), PCYT1A(2), PDHA1(4), PDHA2(14), SLC18A3(6) 5331209 37 33 37 19 4 10 14 4 5 0 0.874 1.000 1.000 577 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(7), EIF2AK4(7), EIF2B5(4), EIF2S1(2), EIF2S2(6), EIF2S3(1), EIF5(3), GSK3B(3), PPP1CA(1) 8797320 34 33 34 14 3 9 10 4 8 0 0.895 1.000 1.000 578 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(8), EPO(2), EPOR(2), GRIN1(4), HIF1A(3), JAK2(5), NFKB1(5), NFKBIA(1), RELA(2), SOD2(1) 9657990 33 33 33 10 4 11 6 7 5 0 0.276 1.000 1.000 579 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(3), ICAM1(6), ITGAL(7), ITGAM(8), ITGB2(4), SELE(7), SELL(2) 7886915 37 33 37 21 4 9 7 5 12 0 0.895 1.000 1.000 580 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(4), ACTR2(1), ARPC1B(3), ARPC2(2), ARPC3(1), ARPC4(1), CDC42(3), RAC1(15), WASF1(3), WASL(2) 6161554 35 33 28 15 10 9 7 7 2 0 0.769 1.000 1.000 581 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 AKR1B10(4), DHRS1(2), DHRS2(4), DHRS3(1), DHRS7(1), HSD3B7(2), PON1(7), PON2(1), PON3(9), RDH11(2), RDH12(4) 6840643 37 32 36 17 3 7 11 11 5 0 0.830 1.000 1.000 582 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNAR1(3), IFNAR2(2), JAK1(11), STAT1(7), STAT2(5), TYK2(8) 8257040 36 32 36 16 5 10 7 5 9 0 0.739 1.000 1.000 583 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3D(1), CD4(1), FYN(5), HLA-DRA(1), HLA-DRB1(2), LCK(5), PTPRC(19), ZAP70(2) 6869407 36 32 35 18 3 8 8 7 10 0 0.907 1.000 1.000 584 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CD4(1), CSF1(2), HLA-DRA(1), HLA-DRB1(2), IFNG(2), IL12A(1), IL12B(4), IL13(1), IL1A(1), IL2(2), IL3(1), IL4(1), IL5(2), IL6(2), IL7(1), LTA(4), TGFB1(1), TGFB2(3), TGFB3(1) 10113759 33 31 32 17 5 8 6 8 6 0 0.913 1.000 1.000 585 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), ECHS1(2), EHHADH(5), HADHA(3), SDS(1) 9244748 34 31 34 14 4 5 10 9 6 0 0.825 1.000 1.000 586 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(3), AKR1D1(3), CYP11A1(3), CYP11B1(6), CYP11B2(4), CYP17A1(1), HSD11B2(3), HSD3B1(4), HSD3B2(4) 7004272 31 29 31 15 10 3 8 5 4 1 0.837 1.000 1.000 587 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(3), AKR1D1(3), CYP11A1(3), CYP11B1(6), CYP11B2(4), CYP17A1(1), HSD11B2(3), HSD3B1(4), HSD3B2(4) 7004272 31 29 31 15 10 3 8 5 4 1 0.837 1.000 1.000 588 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(2), ADH1B(2), ADH4(3), ADH5(3), ADH6(1), ADH7(2), ADHFE1(4), ALDH1A3(1), ALDH1B1(4), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), ALDH9A1(3) 10054416 31 29 31 15 4 8 6 7 6 0 0.876 1.000 1.000 589 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(10), GBA(3), MPO(8), PRDX6(1), TPO(11) 6371299 33 29 32 16 11 5 12 2 3 0 0.804 1.000 1.000 590 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(2), CLOCK(6), CRY1(6), CRY2(3), CSNK1E(6), PER1(7) 6487339 30 28 30 11 6 6 8 9 1 0 0.632 1.000 1.000 591 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(4), ACO1(7), ACO2(3), ACSS1(5), ACSS2(2), FH(3), IDH1(4), IDH2(1), MDH1(1), MDH2(1), SUCLA2(1) 10104755 32 28 32 14 3 10 11 2 6 0 0.723 1.000 1.000 592 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(7), CAPN1(3), CAPNS1(2), CAPNS2(2), CDK5(3), CDK5R1(1), CSNK1A1(1), CSNK1D(1), GSK3B(3), MAPT(8) 7011957 31 28 31 10 6 8 10 5 2 0 0.367 1.000 1.000 593 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(1), CTH(3), GGT1(4), MARS(2), MARS2(5), MAT1A(1), PAPSS1(6), PAPSS2(6), SCLY(1), SEPHS1(1) 9404841 30 28 30 12 7 9 7 5 2 0 0.567 1.000 1.000 594 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(3), CS(2), FH(3), IDH2(1), MDH1(1), OGDH(10), SDHA(7), SUCLA2(1) 7148129 28 27 27 10 4 4 11 5 4 0 0.705 1.000 1.000 595 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 CYP51A1(1), DHCR7(1), FDFT1(4), FDPS(2), HMGCR(4), HMGCS1(3), IDI1(1), LSS(4), MVD(2), NSDHL(2), PMVK(4) 10028443 28 25 28 12 9 8 3 4 4 0 0.564 1.000 1.000 596 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 AKR1A1(1), ECHS1(2), EHHADH(5), HADH(4), HADHA(3), HSD17B10(1), HSD17B4(5), NTAN1(1), SIRT1(2), SIRT2(1), SIRT5(2), SIRT7(1), VNN2(2) 9007518 30 24 30 11 0 10 10 5 5 0 0.716 1.000 1.000 597 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(2), ENO2(1), ENO3(3), FARS2(4), GOT1(1), GOT2(3), PAH(7), TAT(1), YARS(7) 6306436 29 24 29 11 0 9 11 3 6 0 0.603 1.000 1.000 598 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(3), ALPL(4), ALPP(3), ALPPL2(7), DHFR(3), FPGS(2), GGH(3) 4978860 25 23 25 11 3 2 13 3 4 0 0.769 1.000 1.000 599 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACOX1(1), ACOX3(2), ELOVL2(1), ELOVL5(1), ELOVL6(1), FADS1(1), FADS2(4), FASN(10), HADHA(3), SCD(1) 10918791 25 23 25 16 5 8 5 2 5 0 0.916 1.000 1.000 600 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3) 6074660 23 22 23 12 4 2 7 6 4 0 0.935 1.000 1.000 601 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3) 6074660 23 22 23 12 4 2 7 6 4 0 0.935 1.000 1.000 602 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(1), FDFT1(4), FDPS(2), HMGCR(4), IDI1(1), LSS(4), MVD(2), NQO1(3), PMVK(4) 8415959 25 22 25 10 10 7 2 2 4 0 0.440 1.000 1.000 603 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GSS(3), NFKB1(5), NOX1(6), RELA(2), SOD1(1), XDH(6) 7528437 23 22 23 13 4 5 6 4 4 0 0.883 1.000 1.000 604 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(1), ALDH1B1(4), ALDH2(1), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), ALDH9A1(3), MIOX(4), UGDH(4) 6469482 22 22 22 10 4 3 4 8 3 0 0.785 1.000 1.000 605 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(3), PLCG1(8), PRKCA(7), PTK2B(4) 5101404 22 22 22 10 5 4 9 3 1 0 0.655 1.000 1.000 606 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(1), ASL(2), CPS1(13), GLS(1), GLUD1(4), GOT1(1) 5928982 22 22 22 10 4 5 5 5 3 0 0.801 1.000 1.000 607 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(5), CYP11A1(3), CYP11B2(4), CYP17A1(1), HSD11B2(3), HSD3B1(4), HSD3B2(4) 5250461 24 21 24 17 7 3 7 2 4 1 0.960 1.000 1.000 608 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(1), ACOX3(2), FADS2(4), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3) 7706334 24 21 24 14 3 6 8 1 6 0 0.916 1.000 1.000 609 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(5), CYP2A13(4), CYP2A6(2), CYP2A7(4), NAT1(2), XDH(6) 6066385 23 20 23 13 3 5 9 4 2 0 0.906 1.000 1.000 610 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAD(2), ALAS2(5), CPO(4), FECH(1), HBA2(2), UROD(1), UROS(4) 5939473 19 19 19 10 2 3 7 6 1 0 0.906 1.000 1.000 611 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CCL3(1), EPO(2), FLT3(6), IGF1(1), IL1A(1), IL3(1), IL6(2), IL9(2), KITLG(1), TGFB1(1), TGFB2(3), TGFB3(1) 6285319 22 19 22 11 6 2 7 5 2 0 0.850 1.000 1.000 612 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS1(2), DHRS2(4), DHRS3(1), DHRS7(1), ESCO1(4), ESCO2(4), SH3GLB1(2) 12617181 18 17 18 10 0 4 5 4 5 0 0.957 1.000 1.000 613 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(2), ALDOA(1), ALDOB(5), ALDOC(4), TPI1(4) 2979765 16 16 16 7 1 6 4 5 0 0 0.692 1.000 1.000 614 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 CKM(3), EIF4E(1), GPT(1), LDHA(1), LDHB(1), LDHC(4), MAPK14(2), NCL(4) 6833447 17 16 17 10 3 2 4 4 4 0 0.949 1.000 1.000 615 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(4), EPHX2(4), HSD3B7(2), RDH11(2), RDH12(4) 3644574 16 15 16 7 3 3 7 3 0 0 0.695 1.000 1.000 616 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(6), SUCLA2(1) 1601806 7 7 7 4 0 2 4 1 0 0 0.831 1.000 1.000