rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(3), ACADM(1), ACADS(3), ACAT1(1), ECHS1(3), HADHA(4) 5419468 15 15 14 0 3 2 4 5 0 1 0.00868 0.0247 1.000 2 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(3), GOT1(3), GOT2(2), TAT(2), TYR(5) 4732052 15 15 15 1 2 1 3 4 5 0 0.149 0.0371 1.000 3 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 AKR1A1(2), ECHS1(3), EHHADH(6), HADHA(4) 4888973 15 15 14 1 1 3 4 4 3 0 0.0385 0.0443 1.000 4 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 3 CD28(1), HLA-DRA(1), HLA-DRB1(6) 1241979 8 7 8 2 1 2 1 2 2 0 0.579 0.0600 1.000 5 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(8), PDXK(2), PDXP(2), PSAT1(2) 4789589 14 14 14 1 3 1 1 6 3 0 0.147 0.0666 1.000 6 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(2), AASDH(5), AASDHPPT(3), AASS(8) 7059407 18 18 18 0 0 4 4 6 4 0 0.0127 0.0750 1.000 7 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(3), CD3E(1), CD3G(2), HLA-A(6), ICAM1(3), ITGAL(7), ITGB2(2), PRF1(1) 8328704 25 24 25 2 1 5 3 10 5 1 0.0302 0.0762 1.000 8 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RAN(2), RANBP2(27), RANGAP1(1) 8187800 30 27 24 3 1 7 4 8 10 0 0.0388 0.0762 1.000 9 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(2), AASDHPPT(3), AASS(8) 4802785 13 13 13 0 0 3 3 4 3 0 0.0402 0.0792 1.000 10 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(3), ACAT1(1), ECHS1(3), EHHADH(6), HADHA(4), HADHB(4) 8443021 21 21 20 1 1 4 5 8 3 0 0.0143 0.105 1.000 11 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(1), ASL(4), CPS1(5), GLS(6), GOT1(3) 7769460 19 19 19 1 0 4 2 7 6 0 0.0803 0.135 1.000 12 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(2), ARG1(1), GLS(6), OAT(2), PRODH(3) 5565788 14 14 14 0 1 2 5 3 3 0 0.0256 0.137 1.000 13 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(3), ICAM1(3), ITGAL(7), ITGAM(9), ITGB2(2), SELE(5), SELL(2) 10626766 31 31 31 4 2 9 5 8 7 0 0.0287 0.144 1.000 14 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(3), GOT2(2), TAT(2) 2651351 7 7 7 1 1 1 2 0 3 0 0.424 0.211 1.000 15 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCR3(2), HLA-DRA(1), HLA-DRB1(6), IL3(1) 2792284 10 9 10 2 0 2 2 2 4 0 0.527 0.231 1.000 16 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(7), EGF(5), EGFR(9), HGS(3), RAB5A(1), TFRC(3) 12803255 28 27 26 0 5 1 5 9 8 0 0.00225 0.237 1.000 17 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(1), RAB11A(1), RAB1A(3), RAB3A(2), RAB4A(1), RAB5A(1), RAB6A(1) 4248633 10 10 10 1 1 1 2 3 3 0 0.261 0.265 1.000 18 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 9 ACAT1(1), ECHS1(3), EHHADH(6), HADHA(4), SDHB(1) 6937189 15 15 14 1 1 3 4 5 2 0 0.0494 0.284 1.000 19 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 9 ACACA(9), CPT1A(2), LEP(1), LEPR(5), PRKAA1(1), PRKAB1(1), PRKAG1(5), PRKAG2(6) 13517197 30 29 30 2 2 6 8 6 8 0 0.00390 0.290 1.000 20 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 CMBL(1) 513607 1 1 1 0 0 0 0 0 1 0 1.000 0.332 1.000 21 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 12 ARF1(1), ARF3(3), CDK2(2), CDK4(6), CDKN1A(3), CDKN1B(1), CFL1(1), E2F1(1), E2F2(1) 6289236 19 19 16 3 0 0 3 5 10 1 0.638 0.334 1.000 22 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3E(1), CD3G(2) 1171958 3 3 3 0 0 0 1 1 1 0 0.585 0.344 1.000 23 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ECHS1(3), HADH(1), HADHA(4), HADHB(4), HSD17B4(1), MECR(4), PPT1(1) 8470284 18 17 18 1 2 3 5 7 1 0 0.0259 0.345 1.000 24 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 14 AKT1(2), AKT2(5), AKT3(3), GRB2(2), ILK(4), MAPK3(3), PDK1(1), PIK3CD(2), PTK2B(3), RBL2(5), SHC1(4), SOS1(8) 17214478 42 38 40 3 6 8 5 11 12 0 0.00360 0.358 1.000 25 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 17 ABCB1(4), AKT1(2), ATM(19), CDKN1A(3), CPB2(6), CSNK1A1(2), FHL2(1), HIF1A(4), IGFBP3(1), NFKBIB(2) 19418629 44 39 40 3 3 4 4 14 17 2 0.0123 0.360 1.000 26 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 GGT1(4), SHMT1(2), SHMT2(5) 4094910 11 11 11 2 1 1 2 4 3 0 0.404 0.366 1.000 27 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 6 HDAC1(2), MAX(5), MYC(1), SP1(2), SP3(2), WT1(3) 6102798 15 15 15 2 0 1 0 7 7 0 0.523 0.372 1.000 28 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 10 CD2(2), CD28(1), CD3E(1), CD3G(2), ICAM1(3), ITGAL(7), ITGB2(2), PTPRC(8) 10274303 26 25 26 3 2 3 3 11 7 0 0.103 0.374 1.000 29 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 12 CD2(2), CD34(2), CD3E(1), CD3G(2), CD58(1), CD8A(1), IL3(1), KITLG(2) 5333673 12 11 12 1 1 1 2 4 4 0 0.282 0.402 1.000 30 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 5 CCR5(1), CD28(1), CD3E(1), CD3G(2) 2342928 5 5 5 1 1 0 1 2 1 0 0.608 0.407 1.000 31 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIAS(2), LIPT1(1) 1538815 3 3 3 1 0 0 0 2 1 0 0.815 0.420 1.000 32 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(2), CD28(1), CD3E(1), CD3G(2), CD8A(1), ICAM1(3), ITGAL(7), ITGB2(2), PTPRC(8) 10584486 27 25 27 3 2 4 3 11 7 0 0.0747 0.434 1.000 33 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(3), GPD2(1), NDUFA1(1), SDHA(9), SDHB(1), SDHD(2), UQCRC1(1) 6536667 18 16 18 3 3 7 3 5 0 0 0.101 0.435 1.000 34 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 9 CD3E(1), CD3G(2), FYN(2), HLA-DRA(1), HLA-DRB1(6), LCK(1), PTPRC(8), ZAP70(1) 7855602 22 20 22 3 1 3 2 10 6 0 0.245 0.440 1.000 35 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 14 AKT1(2), AKT2(5), AKT3(3), CDKN1A(3), ELK1(1), GRB2(2), HRAS(1), MAP2K2(1), NGFR(1), NTRK1(7), PIK3CD(2), SHC1(4), SOS1(8) 13672505 40 37 39 5 3 7 3 18 8 1 0.0281 0.450 1.000 36 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(6), GLS2(4), GLUD2(7) 4425638 17 17 15 4 1 2 3 9 2 0 0.507 0.454 1.000 37 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CCNE1(2), CDK2(2), CDKN1B(1), CUL1(5), E2F1(1), NEDD8(2), RB1(4), RBX1(1), SKP2(1) 8675384 19 19 18 2 1 1 4 2 9 2 0.202 0.488 1.000 38 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 7 CD28(1), CD80(1), HLA-DRA(1), HLA-DRB1(6), IL4(1) 2846625 10 9 10 3 2 2 2 2 2 0 0.574 0.490 1.000 39 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(1) 726871 1 1 1 1 0 0 1 0 0 0 0.957 0.493 1.000 40 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(2), PGLYRP2(3) 1715205 5 5 5 2 1 1 1 2 0 0 0.717 0.495 1.000 41 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(7), CCNE1(2), CDK2(2), CUL1(5), E2F1(1), RB1(4), SKP2(1) 8733824 22 22 19 3 1 2 4 2 11 2 0.196 0.536 1.000 42 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ5(2), COQ6(1), COQ7(1), NDUFA13(2), NDUFB11(1) 4130964 7 7 7 1 3 1 0 1 2 0 0.379 0.541 1.000 43 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CCNE1(2), CDK2(2), CUL1(5), E2F1(1), FBXW7(6), RB1(4) 8487807 20 20 20 3 1 2 5 2 8 2 0.257 0.554 1.000 44 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(5), BMPR1A(1), BMPR1B(2), BMPR2(5) 6194918 13 11 13 0 0 2 3 5 3 0 0.0167 0.605 1.000 45 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 11 CCNA1(7), CCNE1(2), CCNE2(4), CDK2(2), CDK4(6), CDKN1B(1), E2F1(1), E2F2(1) 7808941 24 20 17 3 0 3 4 3 14 0 0.260 0.624 1.000 46 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(3), ICAM1(3), ITGA4(3), ITGAL(7), ITGB1(7), ITGB2(2), SELE(5), SELL(2) 12218157 32 31 32 5 1 9 6 8 8 0 0.0811 0.635 1.000 47 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM2(1), CAMK1(3), CAMK1G(3), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(3), CAMKK1(4), CAMKK2(3), SYT1(1) 11606698 23 23 22 2 2 3 4 7 7 0 0.0708 0.636 1.000 48 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 AKR1A1(2), ECHS1(3), EHHADH(6), HADH(1), HADHA(4), HSD17B4(1), NTAN1(1), SIRT1(5), SIRT5(1), SIRT7(2), VNN2(1) 11898675 27 26 26 4 3 5 5 6 8 0 0.0814 0.641 1.000 49 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(6), CTH(2), GOT1(3), GOT2(2), LDHB(2), LDHC(3), MPST(2) 6773580 20 20 18 4 1 0 3 6 10 0 0.644 0.641 1.000 50 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 10 CASP7(1), DFFA(1), DFFB(1), HMGB1(3), HMGB2(3), TOP2A(5), TOP2B(6) 10113287 20 19 20 2 3 3 2 5 6 1 0.201 0.643 1.000 51 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(5), EGFR(9), ERBB3(6), NRG1(3), UBE2D1(2) 10301766 25 25 23 4 4 2 2 8 9 0 0.260 0.644 1.000 52 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT1(1), HMGCL(2), OXCT1(2) 3424685 5 5 5 1 0 1 0 2 2 0 0.588 0.645 1.000 53 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 GRB2(2), HRAS(1), PTK2B(3), SHC1(4), SOS1(8), SRC(3) 8688524 21 19 21 3 1 7 1 7 5 0 0.149 0.649 1.000 54 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 11 CBL(3), CSF1R(6), EGF(5), EGFR(9), GRB2(2), PDGFRA(6), PRKCA(2), SH3GLB1(3), SH3GLB2(1), SH3KBP1(3), SRC(3) 16619090 43 39 41 5 4 7 5 14 13 0 0.0507 0.657 1.000 55 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(1), HGD(3) 2260400 4 4 4 1 0 0 1 0 3 0 0.830 0.663 1.000 56 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(5), ENO2(1), ENO3(2), GOT1(3), GOT2(2), PAH(5), TAT(2), YARS(1) 8346172 21 19 21 3 2 2 5 5 7 0 0.165 0.664 1.000 57 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(2), CAMP(1), DAG1(3), ITPKA(1), ITPKB(3) 5726775 10 9 10 1 2 1 2 0 5 0 0.328 0.703 1.000 58 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(3), ICAM1(3), ITGA4(3), ITGAL(7), ITGAM(9), ITGB1(7), ITGB2(2), SELE(5), SELL(2), SELP(2) 16189587 43 41 43 7 2 11 8 12 10 0 0.0531 0.711 1.000 59 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 17 CBL(3), EGF(5), EGFR(9), GRB2(2), HRAS(1), MAPK3(3), PTPRB(5), RAF1(4), RASA1(7), SHC1(4), SOS1(8), SPRY1(1), SPRY2(3), SRC(3) 24503919 58 52 56 6 4 14 8 18 14 0 0.00569 0.723 1.000 60 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(3), HPRT1(1), IMPDH1(1), MTHFD2(2), POLB(2), POLD1(7), POLG(6), PRPS2(4), RRM1(2) 12380440 28 27 26 3 2 5 2 10 9 0 0.0999 0.727 1.000 61 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(1), IARS(4), LARS(7), LARS2(2), PDHA1(1), PDHA2(3), PDHB(1) 10131170 19 17 19 2 2 3 3 5 6 0 0.134 0.727 1.000 62 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDFT1(2), FDPS(1), IDI1(1), IDI2(2), SQLE(1) 4384154 7 7 7 1 1 1 0 2 3 0 0.552 0.732 1.000 63 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(2), GNAS(6), GNB1(3), PRKACA(2), PRKAR1A(2) 6330917 15 15 15 3 2 1 1 10 1 0 0.512 0.735 1.000 64 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(3), ALPL(4), ALPP(5), ALPPL2(5), FPGS(3), GGH(2) 6105520 22 20 22 6 4 5 4 7 2 0 0.233 0.738 1.000 65 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 9 CCR3(2), HLA-DRA(1), HLA-DRB1(6), IL1B(1), IL4(1), IL5RA(2) 4231158 13 12 13 4 1 3 3 2 4 0 0.702 0.743 1.000 66 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CD80(1), CR1(8), CR2(4), HLA-DRA(1), HLA-DRB1(6), ICAM1(3), ITGAL(7), ITGB2(2), PTPRC(8) 15076622 40 38 40 7 4 5 3 17 11 0 0.202 0.756 1.000 67 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 FOSB(2), GRIA2(4), PPP1R1B(1) 3691951 7 7 7 2 1 1 1 3 1 0 0.649 0.760 1.000 68 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 5 GBA(3), GGT1(4), SHMT1(2), SHMT2(5) 4912337 14 14 14 4 1 1 2 6 4 0 0.628 0.773 1.000 69 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDFT1(2), FDPS(1), IDI1(1), SQLE(1) 3294606 5 5 5 1 0 1 0 2 2 0 0.743 0.777 1.000 70 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(3), F13B(4), HSD17B1(1), HSD17B2(1), HSD17B4(1), HSD17B7(1), HSD3B1(1) 8078703 12 11 12 1 2 3 2 4 1 0 0.103 0.783 1.000 71 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDOA(2), ALDOB(3), ALDOC(1), TPI1(2) 3865278 8 8 8 4 0 0 3 0 5 0 0.973 0.802 1.000 72 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 10 ACLY(8), ACO1(5), ACSS1(3), ACSS2(7), FH(2), IDH1(2), MDH1(2), MDH2(1), SUCLA2(2) 12531428 32 27 31 5 1 5 3 11 11 1 0.156 0.803 1.000 73 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALT(3), UGDH(1), UXS1(1) 3998272 5 5 5 1 0 1 3 1 0 0 0.500 0.806 1.000 74 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(1), CDC25B(1), CDKN1A(3), CHEK1(1), NEK1(3), WEE1(2) 7392778 11 10 11 1 0 2 0 5 3 1 0.314 0.810 1.000 75 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 5 ABCB1(4), ABCB11(4), ABCB4(8), ABCC3(8), GSTP1(2) 11495894 26 25 23 4 1 4 7 7 7 0 0.138 0.814 1.000 76 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD28(1), CD3E(1), CD3G(2), IL2RA(2), IL4(1), TGFB2(2), TGFBR1(1), TGFBR2(2), TGFBR3(3), TOB1(5), TOB2(3) 10680453 23 23 23 4 1 3 6 7 6 0 0.232 0.815 1.000 77 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 HLCS(2), SPCS1(2) 3085202 4 4 4 1 0 0 1 2 1 0 0.669 0.819 1.000 78 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(8), AGT(4), AGTR1(2), AGTR2(1), BDKRB2(1), KNG1(4), NOS3(3), REN(1) 9667579 24 23 22 4 2 4 2 9 7 0 0.197 0.823 1.000 79 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 8 ACO1(5), FH(2), IDH1(2), MDH1(2), MDH2(1), SDHB(1), SUCLA2(2) 8155773 15 15 15 3 1 2 1 7 4 0 0.325 0.843 1.000 80 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(1), CYP2C9(1) 2032463 2 2 2 1 0 0 0 1 1 0 0.774 0.843 1.000 81 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 8 ALDH1B1(4), ALDH2(4), ALDH3A2(2), ALDH7A1(1), MIOX(2), UGDH(1) 7499731 14 14 14 3 1 3 4 3 3 0 0.363 0.845 1.000 82 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(5), FOS(1), GRB2(2), HRAS(1), IL3(1), JAK2(7), MAPK3(3), PTPN6(3), RAF1(4), SHC1(4), SOS1(8), STAT5A(3), STAT5B(3) 17543882 45 42 44 6 6 4 7 16 12 0 0.0570 0.851 1.000 83 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNGR1(3), IFNGR2(2), JAK1(6), JAK2(7), STAT1(5) 8316258 23 23 23 5 3 0 3 10 7 0 0.552 0.852 1.000 84 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALT(3), UGDH(1), UGP2(1), UXS1(1) 5057310 6 6 6 1 0 1 4 1 0 0 0.382 0.856 1.000 85 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA1(1), NDUFA10(1), NDUFA11(2), NDUFB2(2), NDUFB4(1), NDUFB5(3), NDUFB6(1), NDUFB7(1), NDUFS1(8), NDUFS2(1), NDUFV1(2), NDUFV2(1) 7042130 24 24 23 5 0 1 3 10 10 0 0.541 0.858 1.000 86 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(5), ATIC(2), GART(4), MTHFD1(7), MTHFD1L(4), MTHFD2(2), MTHFR(1), SHMT1(2), SHMT2(5), TYMS(1) 17963465 33 32 33 4 3 6 3 15 6 0 0.0580 0.867 1.000 87 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(2), EPHX2(1), RDH11(4), RDH13(1) 4715015 8 8 8 2 1 0 1 6 0 0 0.595 0.874 1.000 88 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BAG4(1), BIRC3(5), CASP8(1), RIPK1(1), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TRADD(2), TRAF2(1) 8049816 14 14 14 3 0 4 4 4 2 0 0.386 0.877 1.000 89 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 14 APAF1(3), ATM(19), CCNE1(2), CDK2(2), CDK4(6), CDKN1A(3), E2F1(1), PCNA(3), RB1(4) 17036308 43 37 39 6 2 3 5 9 21 3 0.190 0.885 1.000 90 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GSR(1), GSS(1), NFKB1(2), NOX1(7), RELA(6), TNF(1), XDH(6) 9878723 24 21 19 3 1 2 5 5 10 1 0.331 0.887 1.000 91 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(6), CYP51A1(2), DHCR24(1), DHCR7(3), FDFT1(2), FDPS(1), GGCX(2), HSD17B7(1), IDI1(1), IDI2(2), LSS(4), MVK(1), NSDHL(3), PMVK(1), SQLE(1), TM7SF2(3), VKORC1(1) 19285921 35 32 33 2 2 5 2 14 12 0 0.0165 0.889 1.000 92 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(1) 1643608 1 1 1 0 0 0 0 1 0 0 0.838 0.889 1.000 93 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 MTMR1(2), MTMR2(3), MTMR6(1), NFS1(1), PHPT1(1), THTPA(1), TPK1(1) 6441584 10 10 10 2 1 2 2 5 0 0 0.387 0.898 1.000 94 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 10 ARSB(1), GALNS(6), GLB1(5), GNS(4), GUSB(5), HEXA(4), IDS(2), LCT(7), NAGLU(2) 13652659 36 32 36 7 5 5 4 11 11 0 0.180 0.906 1.000 95 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 NRF1(1), UBE2A(2), UBE2D1(2), UBE2D2(1), UBE2D3(2), UBE2H(2), UBE2I(1), UBE2J1(1), UBE2J2(1), UBE2L3(1), UBE2N(2), UBE3A(2) 10471665 18 18 18 3 1 2 2 9 4 0 0.296 0.906 1.000 96 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(3), FDFT1(2), FDPS(1), IDI1(1), LSS(4), MVK(1), NQO2(1), PMVK(1), SQLE(1), VKORC1(1) 11094202 16 16 16 1 0 2 2 7 5 0 0.115 0.909 1.000 97 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(4), CYP2E1(1), NR1I3(1), PTGS1(2), PTGS2(5) 5259683 13 13 13 4 2 1 2 4 3 1 0.702 0.913 1.000 98 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 B3GNT1(2), FUT2(2), GCNT2(3), ST8SIA1(2) 5908503 9 9 9 2 2 1 1 5 0 0 0.393 0.919 1.000 99 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNB1(1), CCNH(1), CDC25A(1), CDC25B(1), CDC25C(3), MNAT1(1), SHH(3), XPO1(7) 8685207 18 18 18 4 1 2 7 6 2 0 0.298 0.922 1.000 100 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(6), F13A1(3), F2(3), F2R(2), FGA(4), FGB(3), FGG(6), PLAT(4), PLG(8), SERPINB2(1) 13504810 40 37 35 8 6 3 5 15 11 0 0.219 0.923 1.000 101 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 10 C1QA(1), C1R(4), C2(4), C3(8), C5(6), C6(3), C7(4), C8A(1) 16103490 31 29 29 4 4 4 2 14 6 1 0.110 0.928 1.000 102 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 AOC2(4), AOC3(2), CES1(8), ESD(1) 5734455 15 15 13 4 0 2 3 5 5 0 0.535 0.932 1.000 103 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(1), GPR161(2), GPR171(1), GPR18(2), GPR39(2), GPR45(3), GPR65(5), GPR75(1) 9703900 17 17 17 4 3 4 0 7 2 1 0.212 0.933 1.000 104 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(2), CSAD(3), GAD1(2), GAD2(2), GGT1(4) 5683713 13 13 13 4 2 1 5 2 3 0 0.505 0.934 1.000 105 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 8 ALDOB(3), ENO1(5), HK1(6), PFKL(3), PGK1(3), PKLR(1), TPI1(2) 7884201 23 22 23 6 4 3 3 6 7 0 0.331 0.935 1.000 106 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 ANP32A(4), APEX1(2), CREBBP(9), DFFA(1), DFFB(1), HMGB2(3), PRF1(1) 10462724 21 20 21 4 4 3 5 2 7 0 0.122 0.938 1.000 107 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(2), CHRNA1(3), STX1A(1), VAMP2(1) 3211172 7 6 7 4 0 1 0 3 3 0 0.937 0.939 1.000 108 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 CYP51A1(2), DHCR7(3), FDFT1(2), FDPS(1), HMGCS1(2), IDI1(1), LSS(4), MVK(1), NSDHL(3), PMVK(1), SQLE(1) 13226697 21 18 21 1 0 4 2 8 7 0 0.0474 0.948 1.000 109 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(2), CYP11A1(2), CYP11B2(2), CYP17A1(3), HSD11B2(1), HSD3B1(1) 6759353 11 9 11 2 1 0 1 9 0 0 0.380 0.949 1.000 110 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(5), GABBR1(5), GPRC5A(2), GPRC5B(2), GPRC5C(1), GPRC5D(1), GRM1(4), GRM2(5), GRM3(5), GRM4(6), GRM5(8), GRM7(5), GRM8(3) 19738245 52 45 49 9 8 8 5 19 12 0 0.0934 0.949 1.000 111 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 11 ALDH1A1(1), ALDH1A2(1), ALDH1B1(4), ALDH2(4), ALDH3A2(2), ECHS1(3), EHHADH(6), HADHA(4) 11162719 25 25 24 5 2 5 7 8 3 0 0.153 0.950 1.000 112 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 8 HRAS(1), MMP14(1), MMP2(6), MMP9(1), RECK(1), TIMP2(1) 7118269 11 11 11 3 2 2 1 3 3 0 0.558 0.952 1.000 113 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(2), POLD1(7), POLE(5), POLG(6), POLL(2), POLQ(14) 16460708 36 33 34 4 3 1 2 14 16 0 0.183 0.955 1.000 114 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNA1(1), IFNAR1(3), IFNB1(2), JAK1(6), STAT1(5), STAT2(7), TYK2(7) 10778339 31 26 30 7 4 5 4 7 11 0 0.242 0.955 1.000 115 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(21), MAP2(4), PPP1CA(1), PPP2CA(1), PRKACB(2), PRKACG(2), PRKAG1(5), PRKAR2A(1), PRKAR2B(3), PRKCE(4) 18075505 44 41 41 7 5 3 3 17 15 1 0.147 0.960 1.000 116 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 28 ATG12(1), ATG3(1), ATG7(6), BECN1(2), IFNA1(1), IFNA14(1), IFNA16(2), IFNA2(1), IFNA21(3), IFNA5(1), IFNA7(3), IFNA8(2), INS(1), PIK3C3(4), PIK3R4(5), PRKAA1(1), ULK1(2), ULK2(3), ULK3(3) 20079890 43 41 43 7 4 3 3 24 9 0 0.210 0.960 1.000 117 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 DCN(3), FMOD(3), KERA(1), LUM(1) 3580606 8 8 8 3 0 1 0 5 2 0 0.790 0.962 1.000 118 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(3), DCXR(1), GUSB(5), RPE(2), UCHL1(1), UCHL3(1), UGDH(1), UGT1A1(5), UGT1A3(1), UGT1A4(2), UGT1A5(2), UGT1A6(3), UGT1A7(3), UGT1A9(5), UGT2B15(1), UGT2B4(4) 17550099 40 36 40 7 3 6 10 9 12 0 0.147 0.964 1.000 119 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 16 ADCY1(2), GNAS(6), GNB1(3), PPP2CA(1), PRKAA1(1), PRKAB1(1), PRKACB(2), PRKACG(2), PRKAG1(5), PRKAG2(6), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3) 14024223 35 35 35 6 5 3 2 15 10 0 0.168 0.965 1.000 120 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 19 B2M(3), HLA-A(6), ITGB1(7), KLRC1(3), KLRC2(3), KLRC3(2), MAPK3(3), PAK1(3), PIK3R1(5), PTK2B(3), PTPN6(3), SYK(2), VAV1(4) 16512172 47 40 46 9 3 7 5 14 16 2 0.353 0.968 1.000 121 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYA(1), NFYC(2), RB1(4), SP1(2), SP3(2) 6742291 11 11 11 3 0 2 0 2 5 2 0.835 0.972 1.000 122 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 12 ACAA1(3), ACOX1(2), ACOX3(5), ELOVL2(1), ELOVL6(1), FADS1(1), FADS2(2), FASN(9), HADHA(4), PECR(4) 13539916 32 26 32 5 4 8 2 16 2 0 0.0445 0.974 1.000 123 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(1), EPHA4(2), EPHB1(4), FYN(2), ITGA1(8), ITGB1(7), L1CAM(5), LYN(1), SELP(2) 15696413 32 31 30 5 4 4 2 13 9 0 0.173 0.975 1.000 124 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 8 CHUK(2), DNAJC3(2), EIF2S2(2), NFKB1(2), NFKBIA(2), RELA(6) 9173529 16 16 13 3 1 4 0 4 6 1 0.483 0.975 1.000 125 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP1(1), ACP2(1), ACP5(2), ENPP1(4), ENPP3(2), FLAD1(4), TYR(5) 9661735 19 18 19 4 0 4 0 11 4 0 0.506 0.978 1.000 126 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(1), FOSL2(1), IFNAR1(3), IFNB1(2), NFKB1(2), RELA(6), TRAF6(2) 10827165 17 17 14 3 2 5 0 2 7 1 0.421 0.979 1.000 127 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 7 ALDH1A1(1), ALDH1A2(1), ALDH1B1(4), ALDH2(4), ALDH3A2(2) 6952456 12 12 12 4 1 2 4 4 1 0 0.604 0.979 1.000 128 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 7 ALDH1A1(1), ALDH1A2(1), ALDH1B1(4), ALDH2(4), ALDH3A2(2) 6952456 12 12 12 4 1 2 4 4 1 0 0.604 0.979 1.000 129 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ADAM17(2), ERBB4(10), NRG2(3), NRG3(5), PRKCA(2) 9122312 22 22 22 5 3 4 3 9 3 0 0.356 0.980 1.000 130 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 13 C1QA(1), C1R(4), C2(4), C3(8), C5(6), C6(3), C7(4), C8A(1), MASP1(4), MASP2(1), MBL2(2) 19971730 38 36 36 5 6 5 3 16 7 1 0.0610 0.981 1.000 131 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 ACAT1(1), CCL2(1), LDLR(3), LPL(3) 5223024 8 8 8 3 0 2 0 4 2 0 0.679 0.983 1.000 132 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(8), C5(6), C6(3), C7(4), C8A(1) 12856880 22 21 22 4 2 2 2 12 4 0 0.327 0.983 1.000 133 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(1), F2(3), F2R(2), F5(11), F7(1), FGA(4), FGB(3), FGG(6), PROC(3), PROS1(5), TFPI(2) 16338029 41 39 39 8 5 3 3 14 15 1 0.284 0.983 1.000 134 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(4), POLR2A(13), POLR2B(7), POLR2F(4), POLR2I(1), POLR2J(1), POLRMT(5) 13160936 35 34 32 7 4 5 6 9 11 0 0.227 0.984 1.000 135 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 7 CS(2), FH(2), MDH1(2), OGDH(8), SDHA(9), SUCLA2(2) 8631859 25 23 25 7 1 8 0 11 5 0 0.440 0.984 1.000 136 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(5), CS(2), GRHPR(2), HAO1(1), MDH1(2), MDH2(1), MTHFD1(7), MTHFD1L(4), MTHFD2(2) 13478748 26 26 26 5 3 3 3 13 4 0 0.238 0.984 1.000 137 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(2), CDKN1A(3), EPOR(3), GRIN1(2), HIF1A(4), JAK2(7), NFKB1(2), NFKBIA(2), RELA(6) 12667776 31 29 28 6 1 4 4 10 9 3 0.360 0.985 1.000 138 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CCL3(1), FLT3(6), IL3(1), IL9(1), KITLG(2), TGFB2(2) 8353125 13 13 13 3 0 1 3 4 5 0 0.665 0.985 1.000 139 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(5), CS(2), GRHPR(2), HAO1(1), MDH1(2), MDH2(1), MTHFD1(7), MTHFD1L(4), MTHFD2(2) 12849668 26 26 26 5 3 3 3 13 4 0 0.238 0.985 1.000 140 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(1), ALDH1A2(1), RDH5(4) 3854221 6 6 6 3 0 0 4 1 1 0 0.857 0.987 1.000 141 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 6 CD36(1), FOS(1), FYN(2), JUN(2), MAPK14(1) 4844162 7 7 7 3 1 1 0 4 1 0 0.887 0.987 1.000 142 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 16 CD28(1), CD3E(1), CD3G(2), CD80(1), CD86(3), CTLA4(3), GRB2(2), HLA-DRA(1), HLA-DRB1(6), ICOS(3), ITK(1), LCK(1), PIK3R1(5), PTPN11(2) 10445296 32 31 31 7 4 6 3 10 9 0 0.505 0.990 1.000 143 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 CISH(2), IFNGR1(3), JAK1(6), JAK2(7), PTPRU(4), STAT1(5) 11401408 27 25 27 6 4 0 3 14 6 0 0.498 0.990 1.000 144 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(3) 3068084 3 3 3 2 0 1 0 2 0 0 0.956 0.991 1.000 145 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(2), GNB1(3), HTR2C(1), PLCB1(3), TUB(3) 7113832 12 11 12 3 1 2 0 7 2 0 0.565 0.991 1.000 146 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(1), CHAT(5), PCYT1A(1), PDHA1(1), PDHA2(3), SLC18A3(2) 6617312 13 13 11 4 1 2 1 3 6 0 0.801 0.991 1.000 147 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 12 C1QA(1), C1R(4), C2(4), C3(8), C5(6), C6(3), C7(4), C8A(1), C8B(1), MASP1(4) 19418108 36 34 34 5 7 4 2 15 7 1 0.0888 0.992 1.000 148 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 13 AKR1B10(2), DHRS2(1), PON2(2), PON3(5), RDH11(4), RDH13(1) 8273385 15 15 14 4 2 0 3 7 3 0 0.683 0.992 1.000 149 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDK(1), CTH(2), MUT(2) 4850611 5 5 5 2 1 0 1 1 2 0 0.890 0.992 1.000 150 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 B3GALNT1(1), B3GALT5(3), FUT2(2), GBGT1(2), GLA(1), HEXA(4), ST3GAL1(2), ST8SIA1(2) 10462880 17 16 17 4 3 3 2 7 2 0 0.280 0.992 1.000 151 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 22 ACP1(1), ACP2(1), ACP5(2), ACP6(3), ALPI(3), ALPL(4), ALPP(5), ALPPL2(5), CMBL(1), CYP3A43(2), CYP3A5(1), CYP3A7(2), DHRS2(1), PON2(2), PON3(5) 17063096 38 36 36 8 4 7 4 14 9 0 0.227 0.993 1.000 152 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 FUT2(2), FUT3(2), FUT6(4), ST3GAL3(3) 4672695 11 10 9 4 4 1 0 3 3 0 0.766 0.993 1.000 153 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(2), ADH1B(2), ADH4(2), ADH6(2), ADHFE1(3) 5684384 11 11 10 5 1 0 0 7 3 0 0.932 0.993 1.000 154 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(3), LPO(1), MPO(6), PRDX1(1), PRDX5(1), PRDX6(2), TPO(4), TYR(5) 9594681 23 22 23 5 1 2 6 8 6 0 0.391 0.993 1.000 155 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(1), HMOX1(3), IL10RA(4), JAK1(6), STAT1(5), STAT3(3), STAT5A(3), TNF(1) 12086486 26 26 25 5 4 0 1 11 10 0 0.649 0.993 1.000 156 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOA(2), ALDOB(3), ALDOC(1), GOT1(3), GOT2(2), GPT(4), GPT2(2), MDH1(2), MDH2(1), ME1(1), ME3(2), PGK1(3), PGK2(1), PKLR(1), RPE(2), RPIA(2), TKT(2), TKTL1(2), TKTL2(5), TPI1(2) 19919703 43 42 43 8 2 5 8 11 17 0 0.261 0.994 1.000 157 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(4), ANKRD1(1), ATF3(1), EIF4E(2), EIF4EBP1(1), IFRD1(1), IL1R1(3), NR4A3(2), WDR1(2) 10856714 17 17 17 4 1 4 4 5 3 0 0.393 0.994 1.000 158 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 8 ALAS1(5), ALAS2(5), FECH(2), PPOX(2), UROD(2) 6985769 16 16 15 8 1 1 3 6 5 0 0.900 0.994 1.000 159 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOA(2), ALDOB(3), ALDOC(1), GOT1(3), GOT2(2), GPT(4), GPT2(2), MDH1(2), MDH2(1), ME1(1), ME2(3), ME3(2), PGK1(3), PKLR(1), RPE(2), RPIA(2), TKT(2), TPI1(2) 17800341 38 36 38 7 2 5 8 7 16 0 0.256 0.994 1.000 160 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(6), POLR1B(4), POLR1C(2), POLR1D(1), POLR2A(13), POLR2B(7), POLR2F(4), POLR2I(1), POLR2J(1), POLR3A(5), POLR3B(5), POLR3G(1), POLR3H(1), POLR3K(1) 23473829 52 48 49 8 5 7 4 22 14 0 0.0876 0.994 1.000 161 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(2), GAD1(2), HDC(1), TH(4), TPH1(2) 5828899 11 11 11 4 2 2 3 2 2 0 0.692 0.995 1.000 162 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP1(1), ACP2(1), ACP5(2), ACP6(3), ENPP1(4), ENPP3(2), FLAD1(4), MTMR1(2), MTMR2(3), MTMR6(1), PHPT1(1), TYR(5) 15026149 29 28 28 5 0 6 1 18 4 0 0.275 0.995 1.000 163 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(2), IL4R(4), JAK1(6), JAK2(7), TYK2(7) 10359495 26 25 25 8 3 0 5 8 10 0 0.738 0.995 1.000 164 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(2), IL4R(4), JAK1(6), JAK2(7), TYK2(7) 10359495 26 25 25 8 3 0 5 8 10 0 0.738 0.995 1.000 165 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 CASP8(1), CFL1(1), CFLAR(1) 3849704 3 3 3 2 0 0 2 0 1 0 0.942 0.996 1.000 166 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(2), LDLR(3), MBTPS1(3), MBTPS2(1), SCAP(4), SREBF1(4), SREBF2(8) 11734006 25 25 25 6 2 4 5 6 8 0 0.453 0.996 1.000 167 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 PAPSS1(2), PAPSS2(4), SULT1E1(2), SULT2A1(1), SUOX(4) 6145351 13 13 13 5 1 2 4 2 4 0 0.708 0.996 1.000 168 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(3), IFNB1(2), JAK1(6), PTPRU(4), STAT1(5), STAT2(7), TYK2(7) 12301259 34 29 33 8 5 4 4 10 11 0 0.276 0.996 1.000 169 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT1(1), BDH1(1), BDH2(1), HMGCL(2), HMGCS1(2), HMGCS2(1), OXCT1(2) 7281201 10 10 10 3 0 2 1 5 2 0 0.674 0.996 1.000 170 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(8), CS(2), MDH1(2), ME1(1), PC(8), PDHA1(1), SLC25A1(1), SLC25A11(1) 9156149 24 23 24 6 1 3 1 10 9 0 0.530 0.996 1.000 171 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 11 ATM(19), CDC25A(1), CDC25B(1), CDC25C(3), CDK2(2), CDK4(6), CHEK1(1), MYT1(5), RB1(4), WEE1(2) 16965061 44 39 40 9 2 4 6 14 16 2 0.392 0.996 1.000 172 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 ALDOA(2), CTSD(3), GREB1(16), HSPB2(2), MTA1(4), MTA3(3), PDZK1(1) 10599857 31 28 29 8 1 2 7 14 7 0 0.688 0.996 1.000 173 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 36 ANPEP(8), G6PD(2), GCLC(4), GGT1(4), GPX6(1), GSR(1), GSS(1), GSTA1(1), GSTA2(1), GSTA3(1), GSTA4(1), GSTA5(1), GSTK1(1), GSTM1(2), GSTM2(1), GSTM4(1), GSTM5(1), GSTP1(2), GSTT1(2), IDH1(2), OPLAH(7), TXNDC12(1) 21083850 46 40 46 8 4 4 12 16 10 0 0.103 0.997 1.000 174 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 NFKB1(2), NFKBIA(2), PLCB1(3), PRKCA(2), RELA(6) 8271451 15 15 12 7 2 3 0 2 7 1 0.954 0.997 1.000 175 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARSA(2), GOT1(3), GOT2(2), PAH(5), TAT(2), YARS(1), YARS2(1) 8708104 16 16 16 4 1 1 3 5 6 0 0.672 0.997 1.000 176 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 PLCD1(3), PRKCA(2) 4863301 5 5 5 2 0 1 0 2 2 0 0.866 0.997 1.000 177 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREM(1), FOS(1), JUN(2), MAPK3(3), OPRK1(2), POLR2A(13), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3) 12685957 32 31 31 8 10 2 4 10 6 0 0.264 0.997 1.000 178 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(8), CD38(1), ENPP1(4), ENPP3(2), NADSYN1(1), NMNAT2(2), NNMT(1), NNT(7), NT5M(2), QPRT(1) 14586679 29 28 29 6 2 2 3 17 5 0 0.355 0.997 1.000 179 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(19), CDC25A(1), CDC25B(1), CDC25C(3), CHEK1(1), MYT1(5), WEE1(2) 13884133 32 29 31 7 2 4 4 13 9 0 0.372 0.997 1.000 180 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(8), EIF4E(2), FBL(1), GPT(4), LDHB(2), LDHC(3), MAPK14(1), NCL(5) 8935488 26 24 25 8 0 1 10 7 8 0 0.733 0.998 1.000 181 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 21 AKT1(2), CCNE1(2), CDK2(2), CDK4(6), CDK6(1), CDKN1A(3), CDKN1B(1), E2F1(1), HRAS(1), MAPK3(3), NFKB1(2), NFKBIA(2), PAK1(3), PIK3R1(5), RAF1(4), RB1(4), RELA(6) 18039064 48 40 42 9 4 4 5 12 19 4 0.498 0.998 1.000 182 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 16 ADRB2(2), AKT1(2), ANXA1(1), CALM2(1), GNAS(6), GNB1(3), NFKB1(2), NOS3(3), NPPA(1), NR3C1(4), PIK3R1(5), RELA(6), SYT1(1) 15525528 37 35 34 7 5 7 2 13 9 1 0.330 0.998 1.000 183 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 14 CD8A(1), IL3(1), IL4(1), IL9(1) 5091265 4 4 4 2 0 1 2 0 1 0 0.817 0.998 1.000 184 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(5), ATIC(2), FTCD(2), GART(4), MTFMT(1), MTHFD1(7), MTHFD1L(4), MTHFD2(2), MTHFR(1), SHMT1(2), SHMT2(5), TYMS(1) 19046794 36 35 36 7 3 6 3 18 6 0 0.261 0.998 1.000 185 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 12 AKT1(2), BAD(1), CHRNB1(4), MUSK(4), PIK3R1(5), PTK2(3), PTK2B(3), RAPSN(1), SRC(3), TERT(10) 14173411 36 33 36 9 4 10 2 13 7 0 0.337 0.998 1.000 186 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 14 ACADL(3), ACADM(1), ACADS(3), ACSL1(4), ACSL4(1), CPT1A(2), CPT2(2), EHHADH(6), HADHA(4), PECR(4), SCP2(3) 15357545 33 32 31 8 2 8 7 11 4 1 0.175 0.998 1.000 187 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 LPL(3), NR3C1(4), PPARG(2), RETN(1), TNF(1) 5591626 11 11 11 5 1 2 2 3 3 0 0.812 0.998 1.000 188 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 6 ATM(19), ATR(12), CDC25C(3), CHEK1(1), CHEK2(2) 15303497 37 31 36 9 3 4 4 13 13 0 0.572 0.998 1.000 189 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 28 AADAT(2), AASDH(5), AASDHPPT(3), AASS(8), ACAT1(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(4), ALDH2(4), ALDH3A2(2), BBOX1(1), DOT1L(9), ECHS1(3), EHHADH(6), EHMT1(4), EHMT2(8), HADHA(4), PLOD1(2), PLOD2(5), SHMT1(2), SHMT2(5), TMLHE(1) 32683051 81 74 79 13 8 14 14 28 17 0 0.00925 0.998 1.000 190 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 21 CCNA1(7), CCNB1(1), CCND2(1), CCNE1(2), CCNH(1), CDC25A(1), CDK2(2), CDK4(6), CDK6(1), CDKN1A(3), CDKN1B(1), CDKN2C(1), E2F1(1), RB1(4) 15496110 32 28 26 7 1 2 4 6 16 3 0.547 0.999 1.000 191 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(8), C5(6), C6(3), C7(4), ICAM1(3), ITGA4(3), ITGAL(7), ITGB1(7), ITGB2(2), SELP(2), SELPLG(3), TNF(1), VCAM1(6) 24821920 55 51 55 10 5 7 8 25 10 0 0.103 0.999 1.000 192 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(1), CAT(2), EPX(3), LPO(1), MPO(6), MTHFR(1), PRDX6(2), SHMT1(2), SHMT2(5), TPO(4) 11498705 27 26 27 6 1 3 6 10 7 0 0.379 0.999 1.000 193 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 23 ALDH1A1(1), ALDH1A2(1), ALDH1B1(4), ALDH2(4), ALDH3A2(2), ALDH3B1(4), ALDH3B2(3), AOC2(4), AOC3(2), ASPA(1), CNDP1(4), DDC(3), HAL(1), HARS(1), HDC(1), HNMT(2), MAOA(2), MAOB(2), PRPS1(1), PRPS2(4) 23222751 47 45 46 9 5 9 9 16 8 0 0.0656 0.999 1.000 194 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 ADAM17(2), DLL1(1), FURIN(3), NOTCH1(12) 8454303 18 18 16 5 3 4 0 5 5 1 0.573 0.999 1.000 195 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 CISH(2), JAK1(6), JAK2(7), JAK3(4), PIAS1(5), PIAS3(3), PTPRU(4), SOAT1(4) 13744220 35 30 33 8 2 2 8 12 11 0 0.373 0.999 1.000 196 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(3), CAMK1G(3), HDAC9(4), MEF2A(2), MEF2D(1) 8146447 13 13 12 4 2 1 2 3 5 0 0.590 0.999 1.000 197 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 B3GALT1(1), B3GALT2(2), B3GALT5(3), B3GNT5(1), FUT2(2), FUT3(2), ST3GAL3(3), ST3GAL4(2) 6991590 16 15 14 6 5 0 2 3 6 0 0.820 0.999 1.000 198 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 CHST11(1), CHST12(2), PAPSS1(2), PAPSS2(4), SULT1A1(2), SULT1E1(2), SULT2A1(1), SUOX(4) 8895794 18 18 17 6 3 3 4 2 6 0 0.664 0.999 1.000 199 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 10 AHCY(5), BHMT(7), CTH(2), DNMT3B(4), MARS(3), MARS2(4), MAT1A(1), MAT2B(1) 12279257 27 26 27 7 1 5 4 10 7 0 0.505 0.999 1.000 200 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(2), B4GALT1(1), B4GALT3(2), B4GALT5(2), ST3GAL1(2), ST3GAL3(3), ST3GAL4(2) 7686861 14 14 13 7 2 0 2 4 6 0 0.955 0.999 1.000 201 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5E(1), ATP6AP1(4), ATP6V0A1(3), ATP6V0A4(4), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(4), ATP6V1B2(4), ATP6V1D(1), ATP6V1G1(1), SHMT1(2) 15207527 31 29 31 7 2 3 7 12 6 1 0.393 1.000 1.000 202 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5E(1), ATP6AP1(4), ATP6V0A1(3), ATP6V0A4(4), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(4), ATP6V1B2(4), ATP6V1D(1), ATP6V1G1(1), SHMT1(2) 15207527 31 29 31 7 2 3 7 12 6 1 0.393 1.000 1.000 203 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5E(1), ATP6AP1(4), ATP6V0A1(3), ATP6V0A4(4), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(4), ATP6V1B2(4), ATP6V1D(1), ATP6V1G1(1), SHMT1(2) 15207527 31 29 31 7 2 3 7 12 6 1 0.393 1.000 1.000 204 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 35 ACAA1(3), ACADL(3), ACADM(1), ACADS(3), ACADSB(1), ACAT1(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(4), ALDH2(4), ALDH3A2(2), AOX1(8), BCAT1(1), BCKDHA(2), ECHS1(3), EHHADH(6), HADHA(4), HADHB(4), HIBADH(1), HMGCL(2), IVD(2), MCCC1(3), MCCC2(3), MCEE(1), MUT(2), OXCT1(2), PCCA(2), PCCB(3) 35223809 73 71 71 12 5 10 16 27 14 1 0.0233 1.000 1.000 205 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(1), COASY(2), DPYD(5), DPYS(4), ENPP1(4), ENPP3(2), PANK1(2), PANK2(5), PANK3(3), PANK4(1), PPCS(1), UPB1(1) 13783530 31 29 31 8 3 2 3 13 10 0 0.545 1.000 1.000 206 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(1), CYP11A1(2), CYP11B1(4), CYP11B2(2), CYP17A1(3), CYP21A2(2), HSD11B2(1), HSD3B1(1) 9088362 16 15 16 6 1 0 2 8 5 0 0.691 1.000 1.000 207 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(1), CYP11A1(2), CYP11B1(4), CYP11B2(2), CYP17A1(3), CYP21A2(2), HSD11B2(1), HSD3B1(1) 9088362 16 15 16 6 1 0 2 8 5 0 0.691 1.000 1.000 208 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(1), CAPN1(2), CSNK1A1(2), GSK3B(3), MAPT(4), PPP2CA(1) 9382975 13 13 11 8 0 1 2 2 8 0 0.987 1.000 1.000 209 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 19 AKT1(2), EIF4A1(1), EIF4A2(4), EIF4B(5), EIF4E(2), EIF4EBP1(1), EIF4G1(7), EIF4G2(4), EIF4G3(7), MKNK1(2), PDK2(3), PIK3R1(5), PPP2CA(1), RPS6KB1(2), TSC1(5), TSC2(12) 24719664 63 57 61 11 6 10 7 20 17 3 0.0863 1.000 1.000 210 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(2), CREM(1), FHL5(3), FSHR(2), GNAS(6), XPO1(7) 9349842 21 21 21 5 5 1 4 7 4 0 0.518 1.000 1.000 211 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 14 ADH1A(2), ADH1B(2), ADH4(2), ADH5(1), ADH6(2), ADHFE1(3), ALDH1B1(4), ALDH2(4), ALDH3A2(2), ALDH7A1(1) 12371978 23 23 22 7 2 2 3 11 5 0 0.659 1.000 1.000 212 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(5), CTH(2), GGT1(4), MARS(3), MARS2(4), MAT1A(1), MAT2B(1), PAPSS1(2), PAPSS2(4), SCLY(3), SEPHS1(1) 12160401 30 29 30 9 3 5 7 7 8 0 0.501 1.000 1.000 213 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CCNB1(1), CDC25A(1), CDC25B(1), CDC25C(3), CSK(4), GRB2(2), PRKCA(2), PTPRA(5), SRC(3) 9194770 22 20 22 6 0 7 4 8 3 0 0.420 1.000 1.000 214 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(3), GBA(3), LPO(1), MPO(6), PRDX6(2), TPO(4) 8274972 19 18 19 5 1 2 5 6 5 0 0.459 1.000 1.000 215 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 LDLR(3), NR1H3(2), NR1H4(2) 5216943 7 7 7 4 0 2 0 3 2 0 0.851 1.000 1.000 216 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA2A(5), ADORA2B(1), ADORA3(2), P2RY1(3), P2RY2(2), P2RY6(2) 5565472 15 14 15 6 3 2 2 7 1 0 0.580 1.000 1.000 217 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(1), SRP68(2), SRP72(3), SRP9(1), SRPR(1) 7594500 8 7 8 3 1 2 1 3 1 0 0.673 1.000 1.000 218 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CCL2(1), IL1B(1), MST1R(1), TNF(1) 6032580 4 4 4 2 0 1 0 1 2 0 0.944 1.000 1.000 219 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS(6), CARS2(3), CTH(2), GOT1(3), GOT2(2), LDHAL6B(1), LDHB(2), LDHC(3), MPST(2), SULT1B1(2), SULT1C2(1), SULT1C4(3), SULT4A1(1) 12512961 31 31 29 8 2 1 5 11 12 0 0.760 1.000 1.000 220 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(1), AOC2(4), AOC3(2), CES1(8), DDHD1(2), ESCO1(2), ESCO2(1), LIPA(1), PLA1A(3), PNPLA3(3), PRDX6(2), SH3GLB1(3) 25070993 32 30 30 3 1 4 4 9 14 0 0.0818 1.000 1.000 221 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 28 ATF1(2), BAD(1), BRAF(4), CREB5(3), DUSP4(1), DUSP6(2), DUSP9(2), EEF2K(4), EIF4E(2), GRB2(2), MAP2K2(1), MAP3K8(1), MAPK3(3), MKNK1(2), MKNK2(1), MOS(1), NFKB1(2), RAP1A(1), RPS6KA3(3), SHC1(4), SOS1(8), SOS2(7), TRAF3(1) 28001669 58 55 58 10 5 11 12 19 10 1 0.0416 1.000 1.000 222 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(1), CAT(2), EPX(3), LPO(1), MPO(6), PRDX1(1), PRDX5(1), PRDX6(2), SHMT1(2), SHMT2(5), TPO(4) 11705473 28 27 28 7 1 3 7 10 7 0 0.462 1.000 1.000 223 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 19 ACO1(5), CS(2), DLD(4), FH(2), IDH1(2), IDH3B(2), IDH3G(2), MDH1(2), MDH2(1), PC(8), PCK1(5), SDHA(9), SDHB(1), SUCLA2(2), SUCLG1(6), SUCLG2(2) 19750415 55 51 55 13 3 8 7 21 14 2 0.276 1.000 1.000 224 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 12 CNR1(1), CNR2(3), MTNR1B(1), PTAFR(1), PTGDR(1), PTGER2(1), PTGER4(1), PTGFR(5), PTGIR(2), TBXA2R(4) 7363229 20 19 20 9 3 3 2 8 4 0 0.790 1.000 1.000 225 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(3), GABRA2(1), GABRA3(1), GABRA4(1), GABRA5(1), GABRA6(1), PRKCE(4) 7712784 12 12 12 8 0 0 3 6 3 0 0.983 1.000 1.000 226 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX12(3), ALOX15B(3), ALOX5(4), DPEP1(1), GGT1(4), LTA4H(4), PLA2G6(4), PTGDS(1), PTGS1(2), PTGS2(5), TBXAS1(4) 15047940 35 32 33 9 4 5 8 8 9 1 0.357 1.000 1.000 227 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(2), PLCG1(4), PRKCA(2), PTK2B(3) 6689394 11 11 10 6 1 3 1 2 4 0 0.932 1.000 1.000 228 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP5E(1), ATP6AP1(4), ATP6V0A1(3), ATP6V0A4(4), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(4), ATP6V1B2(4), ATP6V1D(1), ATP6V1G1(1), FDXR(2), SHMT1(2) 16061007 33 31 33 8 2 3 7 14 6 1 0.438 1.000 1.000 229 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(3), CLOCK(4), CRY1(1), CSNK1E(3), PER1(5) 8447097 16 16 15 5 2 1 4 4 5 0 0.693 1.000 1.000 230 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(1), PSMA3(2), PSMA4(2), PSMA6(3), PSMA7(1), PSMB1(2), PSMB10(1), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(1) 8538360 16 16 16 5 1 1 1 8 5 0 0.834 1.000 1.000 231 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 13 AKT1(2), BAD(1), CASP9(2), CHUK(2), GHR(1), NFKB1(2), NFKBIA(2), PIK3R1(5), PPP2CA(1), RELA(6) 12011022 24 24 21 6 2 5 1 7 8 1 0.575 1.000 1.000 232 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), HS3ST2(2), HS3ST3A1(1), XYLT1(5), XYLT2(2) 6037936 11 11 11 7 3 3 0 3 2 0 0.806 1.000 1.000 233 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), HS3ST2(2), HS3ST3A1(1), XYLT1(5), XYLT2(2) 6037936 11 11 11 7 3 3 0 3 2 0 0.806 1.000 1.000 234 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(2), GRB2(2), IL4(1), IL4R(4), IRS1(5), JAK1(6), JAK3(4), RPS6KB1(2), SHC1(4), STAT6(5) 14280336 35 33 35 9 6 3 5 12 9 0 0.428 1.000 1.000 235 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 15 AHCY(5), AMD1(2), BHMT(7), CTH(2), DNMT3B(4), MARS(3), MARS2(4), MAT1A(1), MAT2B(1), MTAP(2), MTFMT(1), TAT(2) 15637296 34 33 34 9 3 6 6 12 7 0 0.449 1.000 1.000 236 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 11 ACTR2(2), ARPC1B(1), CDC42(1), PAK1(3), PDGFRA(6), PIK3R1(5) 9708445 18 18 18 7 2 3 1 7 5 0 0.925 1.000 1.000 237 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(8), CD44(3), IL1B(1), IL6R(2), SELL(2), SPN(1), TGFB2(2), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TNFSF8(1) 13133143 23 22 21 5 2 7 3 3 8 0 0.316 1.000 1.000 238 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 B3GNT1(2), B3GNT2(3), B3GNT3(1), B3GNT5(1), B4GALT1(1), B4GALT3(2), B4GALT4(2), FUT2(2), FUT3(2), FUT4(2), FUT6(4), FUT7(1), GCNT2(3), ST8SIA1(2) 15127214 28 26 27 6 6 4 4 9 5 0 0.249 1.000 1.000 239 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 ADAM17(2), APC(9), AXIN1(4), BTRC(2), CTNNB1(2), DLL1(1), DVL1(1), FZD1(3), GSK3B(3), NOTCH1(12), WNT1(2) 20334446 41 39 38 9 5 6 3 16 10 1 0.342 1.000 1.000 240 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 43 ABAT(1), ACAA1(3), ACADM(1), ACADS(3), ACAT1(1), ALDH1B1(4), ALDH2(4), ALDH3A2(2), ALDH7A1(1), AOX1(8), BCAT1(1), BCKDHA(2), DBT(2), DLD(4), ECHS1(3), EHHADH(6), HADH(1), HADHA(4), HADHB(4), HIBADH(1), HIBCH(1), HMGCL(2), HMGCS1(2), HMGCS2(1), HSD17B4(1), IVD(2), MCCC1(3), MCCC2(3), MCEE(1), MUT(2), OXCT1(2), PCCA(2), PCCB(3) 42410540 81 78 79 12 6 9 21 29 15 1 0.00664 1.000 1.000 241 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(3), ELK1(1), EPOR(3), FOS(1), GRB2(2), HRAS(1), JAK2(7), JUN(2), MAPK3(3), PLCG1(4), PTPN6(3), RAF1(4), SHC1(4), SOS1(8), STAT5A(3), STAT5B(3) 21357045 52 49 50 10 4 6 10 18 14 0 0.208 1.000 1.000 242 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(3), BIRC2(2), BIRC3(5), CASP10(3), CASP7(1), CASP8(1), CASP9(2), DFFA(1), DFFB(1), PRF1(1), SCAP(4), SREBF1(4), SREBF2(8) 17987606 36 35 36 8 1 7 6 11 11 0 0.317 1.000 1.000 243 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(4), AGT(4), AGTR2(1), EDNRB(3), EGF(5), EGFR(9), FOS(1), HRAS(1), JUN(2), MYC(1), NFKB1(2), PLCG1(4), PRKCA(2), RELA(6) 20353047 45 39 39 9 5 5 4 17 13 1 0.383 1.000 1.000 244 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(2), ADRB2(2), GNAS(6), PLCE1(6), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), RAP2B(2) 14475925 28 28 28 7 4 3 3 10 8 0 0.496 1.000 1.000 245 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(2), IFNA1(1), IFNB1(2), IKBKB(3), IL1B(1), IL1R1(3), IL1RAP(4), IL1RN(1), IRAK1(3), IRAK3(4), JUN(2), MAP2K3(3), MAP3K1(7), MAP3K7(3), MAPK14(1), NFKB1(2), NFKBIA(2), RELA(6), TGFB2(2), TNF(1), TRAF6(2) 29600469 55 49 51 9 7 12 1 17 16 2 0.112 1.000 1.000 246 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(3), PARK2(2), SNCAIP(4), UBE2E2(1), UBE2L3(1) 6336035 11 11 11 5 1 4 1 3 2 0 0.749 1.000 1.000 247 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CALM2(1), CAMK1(3), CAMK1G(3), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(3), ESRRA(1), HDAC5(3), MEF2A(2), MEF2D(1), PPP3CA(3), PPP3CC(3), SLC2A4(2), SYT1(1) 20534709 31 31 30 5 4 2 4 11 10 0 0.181 1.000 1.000 248 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(3), ARHGAP5(6), ARHGDIB(1), CASP1(3), CASP10(3), CASP8(1), CASP9(2), JUN(2), PRF1(1) 12699345 22 21 22 6 0 4 2 8 8 0 0.737 1.000 1.000 249 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(9), CDH1(2), CREBBP(9), EP300(16), MAP3K7(3), MAPK3(3), SKIL(2), TGFB2(2), TGFBR1(1), TGFBR2(2) 25692930 49 45 46 9 3 5 10 16 14 1 0.109 1.000 1.000 250 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(2), ADRB2(2), CFTR(8), GNAS(6), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), SLC9A3R1(1) 12776536 29 29 29 8 4 2 1 14 8 0 0.655 1.000 1.000 251 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(4), CYP2A13(5), CYP2A6(4), CYP2A7(2), NAT1(1), NAT2(1), XDH(6) 7901121 23 22 23 8 4 3 3 9 4 0 0.713 1.000 1.000 252 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 24 ABAT(1), ACADM(1), ALDH1B1(4), ALDH2(4), ALDH3A2(2), ALDH7A1(1), AOC2(4), AOC3(2), CNDP1(4), DPYD(5), DPYS(4), ECHS1(3), EHHADH(6), GAD1(2), GAD2(2), HADHA(4), HIBCH(1), MLYCD(3), SMS(2), UPB1(1) 25685376 56 54 55 12 3 7 15 15 15 1 0.113 1.000 1.000 253 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(1), FUCA1(2), FUCA2(1), GLB1(5), HEXA(4), LCT(7), MAN2C1(5), MANBA(2), NEU1(1) 16037207 28 27 28 7 3 4 3 13 5 0 0.432 1.000 1.000 254 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 28 DPM2(1), EGFR(9), ELK1(1), GNAS(6), GNB1(3), GRB2(2), HRAS(1), IGF1R(3), ITGB1(7), MAP2K2(1), MAPK3(3), MKNK1(2), MKNK2(1), MYC(1), NGFR(1), PDGFRA(6), PPP2CA(1), PTPRR(4), RAF1(4), RPS6KA5(2), SHC1(4), SOS1(8), SRC(3), STAT3(3) 31290010 77 66 75 15 8 13 7 31 18 0 0.139 1.000 1.000 255 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 18 EXT1(3), EXT2(1), EXTL1(1), EXTL3(3), GLCE(4), HS2ST1(2), HS3ST2(2), HS3ST3A1(1), HS3ST5(1), HS6ST1(3), HS6ST2(3), HS6ST3(1), NDST1(2), NDST2(4), NDST3(1), NDST4(7) 19663279 39 36 38 8 5 4 4 14 12 0 0.288 1.000 1.000 256 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 19 CSNK2A1(3), ELK1(1), FOS(1), GRB2(2), HRAS(1), INS(1), IRS1(5), JUN(2), MAPK3(3), PIK3R1(5), PTPN11(2), RAF1(4), RASA1(7), SHC1(4), SLC2A4(2), SOS1(8) 20023235 51 49 51 11 8 11 4 18 10 0 0.199 1.000 1.000 257 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(1), ST3GAL1(2), ST3GAL4(2), ST3GAL5(1), ST6GALNAC2(3), ST8SIA1(2) 5420228 11 11 11 5 1 2 1 6 1 0 0.712 1.000 1.000 258 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(1), ALDH4A1(2), CAD(12), CPS1(5), EPRS(4), GAD1(2), GAD2(2), GCLC(4), GFPT1(2), GLS(6), GLS2(4), GLUL(2), GMPS(1), GOT1(3), GOT2(2), GPT(4), GPT2(2), GSS(1), NADSYN1(1), PPAT(3), QARS(1) 33229940 64 57 60 10 5 8 12 21 17 1 0.0729 1.000 1.000 259 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 13 CHUK(2), IKBKAP(2), IKBKB(3), MAP3K1(7), NFKB1(2), NFKBIA(2), RELA(6), TNFAIP3(2), TRAF3(1), TRAF6(2) 18573647 29 27 26 5 2 7 0 7 12 1 0.317 1.000 1.000 260 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(4), POLB(2), POLD1(7), POLD3(1), POLE(5), POLE2(1), POLG(6), POLG2(5), POLH(4), POLI(3), POLK(5), POLL(2), POLM(4), POLQ(14), PRIM1(3), PRIM2(4), REV1(5), REV3L(15), RFC5(3) 41235141 93 79 87 15 5 8 6 44 30 0 0.143 1.000 1.000 261 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(2), MAPK14(1), NFKB1(2), RELA(6), TNFRSF13B(1), TNFSF13(1), TRAF2(1), TRAF3(1), TRAF5(5), TRAF6(2) 14523652 22 21 19 5 0 5 0 7 9 1 0.656 1.000 1.000 262 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(2), EIF2AK4(6), EIF2B5(2), EIF2S2(2), EIF2S3(2), EIF5(3), GSK3B(3), PPP1CA(1) 11555478 21 20 19 8 1 1 5 6 8 0 0.851 1.000 1.000 263 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(3), GNAS(6), GNB1(3), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PRKCA(2) 9484817 24 23 24 7 4 3 0 12 5 0 0.643 1.000 1.000 264 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(1), APAF1(3), CASP9(2), DAXX(6), FAS(2), FASLG(2), HSPB2(2), MAPKAPK2(1), TNF(1) 10996543 20 18 20 5 2 5 1 7 5 0 0.496 1.000 1.000 265 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 ASAH1(2), BFAR(1), BRAF(4), CAMP(1), CREB5(3), RAF1(4), SNX13(3), SRC(3) 11545453 21 17 21 6 1 4 4 8 3 1 0.563 1.000 1.000 266 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(3), ABAT(1), ADSL(3), AGXT(2), AGXT2(1), ASL(4), ASNS(2), ASPA(1), CAD(12), CRAT(3), DARS(3), DDO(1), GAD1(2), GAD2(2), GOT1(3), GOT2(2), GPT(4), GPT2(2), PC(8) 25927610 59 52 55 11 2 7 11 13 25 1 0.265 1.000 1.000 267 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(1), B4GALNT1(2), GLB1(5), HEXA(4), LCT(7), SLC33A1(2), ST3GAL1(2), ST3GAL5(1), ST6GALNAC3(3), ST6GALNAC5(4), ST6GALNAC6(1), ST8SIA1(2), ST8SIA5(1) 16040691 35 32 35 9 4 6 2 14 9 0 0.361 1.000 1.000 268 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 30 ABAT(1), ACACA(9), ACADL(3), ACADM(1), ACADSB(1), ACAT1(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(4), ALDH2(4), ALDH3A2(2), ECHS1(3), EHHADH(6), HADHA(4), LDHB(2), LDHC(3), MCEE(1), MLYCD(3), MUT(2), PCCA(2), PCCB(3), SUCLA2(2), SUCLG1(6), SUCLG2(2) 32273349 67 64 65 13 4 9 17 21 14 2 0.0565 1.000 1.000 269 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 29 CS(2), DLAT(2), DLD(4), FH(2), IDH3B(2), IDH3G(2), MDH1(2), MDH2(1), OGDH(8), PC(8), PDHA1(1), PDHA2(3), PDHB(1), PDHX(2), PDK1(1), PDK2(3), PDK3(2), PDK4(1), PDP2(2), SDHA(9), SDHB(1), SDHD(2), SUCLA2(2), SUCLG1(6), SUCLG2(2) 27593149 71 63 71 16 3 13 9 25 19 2 0.174 1.000 1.000 270 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT1(2), B3GNT2(3), B3GNT7(1), B4GALT1(1), B4GALT3(2), B4GALT4(2), CHST1(2), CHST2(2), CHST4(1), CHST6(2), ST3GAL1(2), ST3GAL3(3), ST3GAL4(2) 11591238 25 24 24 8 4 4 2 6 9 0 0.672 1.000 1.000 271 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CHPT1(3), LCMT1(1), LCMT2(4), METTL2B(1), PCYT1A(1), PRMT2(2), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(2), PRMT8(3) 13882855 24 22 24 6 1 2 4 8 9 0 0.611 1.000 1.000 272 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(1), PSMA3(2), PSMA4(2), PSMA6(3), PSMA7(1), PSMB1(2), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(1), RPN1(3), RPN2(1), UBE2A(2), UBE3A(2) 13232474 23 23 23 7 1 2 2 11 7 0 0.782 1.000 1.000 273 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 14 AKT1(2), BCAR1(6), CDKN1B(1), GRB2(2), ILK(4), ITGB1(7), MAPK3(3), PDK2(3), PIK3R1(5), PTK2(3), SHC1(4), SOS1(8) 16160917 48 41 46 12 4 7 4 15 17 1 0.615 1.000 1.000 274 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(3), BAD(1), BAK1(1), BCL10(1), BCL2L11(1), BID(2), CASP9(2), CES1(8) 11444024 19 19 17 5 1 2 3 6 7 0 0.613 1.000 1.000 275 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(1), FUCA1(2), FUCA2(1), GLB1(5), HEXA(4), LCT(7), MAN2B1(1), MAN2B2(2), MAN2C1(5), MANBA(2), NEU1(1) 19751506 31 29 31 7 4 4 4 14 5 0 0.299 1.000 1.000 276 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 12 FOS(1), JUN(2), KEAP1(3), MAPK14(1), PRKCA(2) 7538032 9 9 9 8 1 1 2 3 2 0 0.989 1.000 1.000 277 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(10), APOBEC1(2), APOBEC3B(1), APOBEC3G(1), APOBEC4(1) 7316523 15 14 15 8 3 0 5 6 1 0 0.913 1.000 1.000 278 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 11 DPM2(1), HRAS(1), MAP2K2(1), MAPK3(3), NGFR(1), RAF1(4) 7021019 11 11 11 5 1 1 2 6 1 0 0.878 1.000 1.000 279 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 32 AARS(3), AARS2(3), ABAT(1), ACY3(2), ADSL(3), ADSSL1(2), AGXT(2), AGXT2(1), ASL(4), ASNS(2), ASPA(1), ASS1(3), CAD(12), CRAT(3), DARS(3), DARS2(1), DDO(1), DLAT(2), DLD(4), GAD1(2), GAD2(2), GOT1(3), GOT2(2), GPT(4), GPT2(2), NARS2(6), PC(8), PDHA1(1), PDHA2(3), PDHB(1) 37075490 87 72 83 15 5 10 15 24 31 2 0.0759 1.000 1.000 280 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 30 ANPEP(8), G6PD(2), GCLC(4), GGT1(4), GSS(1), GSTA1(1), GSTA2(1), GSTA3(1), GSTA4(1), GSTM1(2), GSTM2(1), GSTM4(1), GSTM5(1), GSTP1(2), GSTT1(2), IDH1(2) 17455311 34 30 34 9 3 3 10 11 7 0 0.426 1.000 1.000 281 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(6), KHK(6), LCT(7), MPI(1), PGM1(1), PYGL(2), PYGM(4), TPI1(2) 13537100 29 28 29 9 8 1 5 11 4 0 0.470 1.000 1.000 282 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 DAB1(5), FYN(2), LRP8(4), RELN(7), VLDLR(4) 14040613 22 21 17 6 2 4 0 5 11 0 0.891 1.000 1.000 283 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(2), FOS(1), HRAS(1), JUN(2), MAPK3(3), MYC(1), NFKB1(2), NFKBIA(2), PLCB1(3), PRKCA(2), RAF1(4), RELA(6), TNF(1) 15171285 30 29 27 9 6 3 2 8 10 1 0.737 1.000 1.000 284 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 11 DHRS2(1), ESCO1(2), ESCO2(1), PNPLA3(3), SH3GLB1(3) 15818456 10 10 10 2 0 2 2 3 3 0 0.544 1.000 1.000 285 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 14 CCR5(1), CD2(2), CD3E(1), CD3G(2), IL12RB1(4), IL12RB2(2), JAK2(7), STAT4(2), TYK2(7) 13853267 28 28 27 8 3 0 6 11 8 0 0.755 1.000 1.000 286 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 14 AKT1(2), EGFR(9), IGF1R(3), MYC(1), POLR2A(13), PPP2CA(1), PRKCA(2), RB1(4), TEP1(9), TERF1(2), TERT(10), TNKS(6), XRCC5(4) 27088863 66 55 63 15 11 12 5 20 16 2 0.138 1.000 1.000 287 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(5), GNA12(1), PRKACB(2), PRKACG(2), PRKAG1(5), PRKAR2A(1), PRKAR2B(3) 10017406 19 19 19 6 3 2 3 7 4 0 0.616 1.000 1.000 288 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(2), CALCR(3), CALCRL(2), CD97(6), CRHR1(2), CRHR2(3), ELTD1(4), EMR1(2), EMR2(4), GIPR(2), GLP1R(3), GLP2R(3), GPR64(2), LPHN1(5), LPHN2(4), LPHN3(9), SCTR(1), VIPR1(1), VIPR2(2) 27394928 60 52 59 13 11 7 10 21 11 0 0.133 1.000 1.000 289 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 FUT2(2), GBGT1(2), GLA(1), HEXA(4), ST3GAL1(2), ST3GAL4(2), ST8SIA1(2) 9864830 15 15 15 6 1 2 1 8 3 0 0.704 1.000 1.000 290 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(2), HK1(6), IMPA1(1), PGM1(1) 10177273 10 9 10 6 3 0 0 4 3 0 0.895 1.000 1.000 291 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 15 B3GAT1(2), B3GAT2(1), B3GAT3(1), CHPF(1), CHST11(1), CHST12(2), CHST14(1), CHST3(2), CHST7(2), DSE(1), UST(1), XYLT1(5), XYLT2(2) 11335976 22 22 22 9 5 6 0 6 5 0 0.637 1.000 1.000 292 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 20 AKT1(2), BAD(1), CASP9(2), CDC42(1), CHUK(2), ELK1(1), HRAS(1), MAPK3(3), NFKB1(2), PIK3R1(5), RAF1(4), RALA(2), RALBP1(2), RELA(6) 16990469 34 33 30 8 2 6 3 11 11 1 0.596 1.000 1.000 293 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 20 ADCY1(2), CD3E(1), CD3G(2), CREBBP(9), CSK(4), GNAS(6), GNB1(3), HLA-DRA(1), HLA-DRB1(6), LCK(1), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PTPRC(8), ZAP70(1) 21399940 54 49 54 12 6 6 5 24 13 0 0.275 1.000 1.000 294 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 20 ADCY1(2), CD3E(1), CD3G(2), CREBBP(9), CSK(4), GNAS(6), GNB1(3), HLA-DRA(1), HLA-DRB1(6), LCK(1), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PTPRC(8), ZAP70(1) 21399940 54 49 54 12 6 6 5 24 13 0 0.275 1.000 1.000 295 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 17 AKT1(2), EIF2B5(2), EIF2S2(2), EIF2S3(2), EIF4E(2), EIF4EBP1(1), GSK3B(3), IGF1R(3), INPPL1(4), PDK2(3), PIK3R1(5), PPP2CA(1), RPS6KB1(2) 16706000 32 30 30 9 4 4 2 10 12 0 0.594 1.000 1.000 296 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 26 ACLY(8), ACO1(5), CLYBL(3), CS(2), DLD(4), FH(2), IDH1(2), IDH3B(2), IDH3G(2), MDH1(2), MDH2(1), OGDH(8), OGDHL(2), PC(8), PCK1(5), PCK2(2), SDHA(9), SDHB(1), SDHD(2), SUCLA2(2), SUCLG1(6), SUCLG2(2) 28986201 80 70 80 19 5 13 8 31 21 2 0.241 1.000 1.000 297 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 15 ARSB(1), GALNS(6), GLB1(5), GNS(4), GUSB(5), HEXA(4), HGSNAT(3), HPSE(2), HPSE2(4), HYAL1(2), HYAL2(1), IDS(2), LCT(7), NAGLU(2) 18761677 48 41 48 12 6 7 6 17 12 0 0.272 1.000 1.000 298 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 17 DHRS2(1), LCMT1(1), LCMT2(4), METTL2B(1), PRMT2(2), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(2), PRMT8(3) 14109858 21 19 21 5 1 2 5 6 7 0 0.481 1.000 1.000 299 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 25 AKT1(2), AKT2(5), AKT3(3), BAD(1), GRB2(2), GSK3A(2), GSK3B(3), IL4R(4), IRS1(5), JAK1(6), JAK3(4), MAP4K1(4), MAPK3(3), PDK1(1), PIK3CD(2), PIK3R1(5), PPP1R13B(4), RAF1(4), SHC1(4), SOS1(8), SOS2(7), STAT6(5) 32874411 84 72 82 17 12 11 17 26 18 0 0.0625 1.000 1.000 300 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(9), ACACB(5), FASN(9), MCAT(2), OLAH(2), OXSM(3) 15626713 30 30 30 9 3 7 5 10 5 0 0.394 1.000 1.000 301 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNA1(1), IFNB1(2), IL15(1), IL16(5), IL3(1), IL4(1), IL9(1), LTA(1), TNF(1) 9777111 14 14 14 7 0 5 2 5 2 0 0.871 1.000 1.000 302 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACOT11(1), ALDH1B1(4), ALDH2(4), ALDH3A2(2), ALDH7A1(1), CYP2C19(1), CYP2C9(1), DHRS2(1), ECHS1(3), EHHADH(6), ESCO1(2), ESCO2(1), HADHA(4), PNPLA3(3), SH3GLB1(3), YOD1(2) 29167374 39 38 38 7 2 7 8 11 11 0 0.128 1.000 1.000 303 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(9), AXIN1(4), BTRC(2), CREBBP(9), CSNK1A1(2), CSNK2A1(3), CTBP1(2), CTNNB1(2), DVL1(1), FZD1(3), GSK3B(3), HDAC1(2), MAP3K7(3), MYC(1), NLK(1), PPARD(1), PPP2CA(1), TLE1(6), WIF1(5), WNT1(2) 29096292 62 54 56 13 6 5 7 20 23 1 0.239 1.000 1.000 304 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 11 AKT1(2), CAT(2), GHR(1), HRAS(1), IGF1R(3), PIK3R1(5), SHC1(4) 10825227 18 16 18 9 3 2 1 8 4 0 0.957 1.000 1.000 305 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 31 ADH1A(2), ADH1B(2), ADH4(2), ADH6(2), ADHFE1(3), ALDH3B1(4), ALDH3B2(3), AOC2(4), AOC3(2), AOX1(8), DBH(2), DCT(4), DDC(3), FAH(1), GOT1(3), GOT2(2), HGD(3), HPD(2), MAOA(2), MAOB(2), TAT(2), TH(4), TPO(4), TYR(5) 30366538 71 65 69 17 11 6 8 26 20 0 0.311 1.000 1.000 306 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 22 ACAT1(1), ACOT11(1), DHRS2(1), ECHS1(3), EHHADH(6), ESCO1(2), ESCO2(1), FN3K(1), HADHA(4), PNPLA3(3), SH3GLB1(3), YOD1(2) 24267951 28 28 27 5 1 5 5 8 9 0 0.274 1.000 1.000 307 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(8), ATP5E(1), ATP6AP1(4), ATP6V0A1(3), ATP6V0A4(4), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(4), ATP6V1B2(4), ATP6V1D(1), ATP6V1G1(1), ATP7A(5), ATP7B(7), COX10(5), COX5A(1), COX7A1(2), COX8A(1), NDUFA1(1), NDUFA10(1), NDUFA11(2), NDUFB2(2), NDUFB4(1), NDUFB5(3), NDUFB6(1), NDUFB7(1), NDUFS1(8), NDUFS2(1), NDUFV1(2), NDUFV2(1), PPA2(2), SDHA(9), SDHB(1), SHMT1(2), UQCRC1(1), UQCRFS1(2) 38390393 99 89 97 21 7 15 18 38 20 1 0.0948 1.000 1.000 308 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 28 HLA-DRA(1), HLA-DRB1(6), IFNA1(1), IFNB1(2), IL15(1), IL3(1), IL4(1), LTA(1), TGFB2(2), TNF(1) 12046466 17 16 17 6 0 5 3 5 4 0 0.739 1.000 1.000 309 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(2), HK1(6), IMPA1(1), IMPA2(3), PGM1(1) 11508127 13 12 13 7 4 0 0 5 4 0 0.901 1.000 1.000 310 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(9), AXIN1(4), CREBBP(9), CTNNB1(2), DVL1(1), EP300(16), FZD1(3), GSK3B(3), HDAC1(2), LDB1(2), LEF1(3), PITX2(2), TRRAP(12), WNT1(2) 32696619 70 61 61 14 5 4 10 27 24 0 0.252 1.000 1.000 311 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 CAD(12), CANT1(1), DCK(1), DCTD(1), DPYD(5), DPYS(4), DTYMK(1), ENTPD1(1), NT5M(2), POLB(2), POLD1(7), POLE(5), POLG(6), POLL(2), POLQ(14), POLR1B(4), POLR2A(13), POLR2B(7), POLR2F(4), POLR2I(1), POLR2J(1), POLRMT(5), RRM1(2), RRM2(1), TK1(1), TK2(2), TXNRD1(2), TYMS(1), UCK1(1), UCK2(1), UMPS(1), UNG(1), UPB1(1), UPP1(2) 57025029 115 93 106 19 9 14 16 32 42 2 0.0311 1.000 1.000 312 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 21 ALDH3B1(4), ALDH3B2(3), AOC2(4), AOC3(2), DDC(3), EPX(3), GOT1(3), GOT2(2), HPD(2), LPO(1), MAOA(2), MAOB(2), MPO(6), PRDX1(1), PRDX5(1), PRDX6(2), TAT(2), TPO(4) 20698523 47 43 46 11 7 5 11 12 12 0 0.224 1.000 1.000 313 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 20 ALG3(3), ALG5(2), B4GALT1(1), B4GALT3(2), B4GALT5(2), DPM1(1), MAN1A1(2), MAN1B1(1), MGAT2(1), MGAT3(1), MGAT4A(3), MGAT4B(1), MGAT5(4), RPN1(3), RPN2(1), ST6GAL1(1) 18566422 29 28 29 8 2 6 1 10 10 0 0.534 1.000 1.000 314 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 25 CSNK2A1(3), EGF(5), EGFR(9), ELK1(1), FOS(1), GRB2(2), HRAS(1), JAK1(6), JUN(2), MAP3K1(7), MAPK3(3), PIK3R1(5), PLCG1(4), PRKCA(2), RAF1(4), RASA1(7), SHC1(4), SOS1(8), STAT1(5), STAT3(3), STAT5A(3) 35212701 85 75 81 17 10 13 7 26 29 0 0.264 1.000 1.000 315 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(1), CYB5R3(2), GCK(2), GFPT1(2), GNE(1), GNPDA1(1), HEXA(4), HK1(6), RENBP(4) 16947245 23 22 23 6 3 0 2 10 8 0 0.597 1.000 1.000 316 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ACY1(3), ALDH18A1(2), ARG1(1), ARG2(1), ASL(4), CKB(1), CKMT1B(1), CPS1(5), GATM(1), NAGS(1), OAT(2), ODC1(2), OTC(1), PYCR1(1), SMS(2) 17506301 28 28 28 8 0 2 5 12 9 0 0.784 1.000 1.000 317 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 AKR1B1(3), DCXR(1), GUSB(5), RPE(2), UGDH(1), UGP2(1), UGT1A1(5), UGT1A3(1), UGT1A4(2), UGT1A5(2), UGT1A6(3), UGT1A7(3), UGT1A9(5), UGT2A1(3), UGT2A3(3), UGT2B11(2), UGT2B15(1), UGT2B17(1), UGT2B28(5), UGT2B4(4), UGT2B7(6), XYLB(2) 27074632 61 56 61 14 5 7 14 18 17 0 0.309 1.000 1.000 318 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 27 CCL3(1), CCR2(2), CCR3(2), CCR5(1), CCR7(1), CD28(1), CXCR4(1), IFNGR1(3), IFNGR2(2), IL12RB1(4), IL12RB2(2), IL18R1(1), IL4(1), IL4R(4), TGFB2(2) 19119987 28 26 28 8 5 1 4 10 8 0 0.532 1.000 1.000 319 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 16 ACTA1(1), ACTR2(2), ARPC1B(1), NCK1(1), NCKAP1(2), NTRK1(7), PIR(1), PSMA7(1), WASF1(1), WASF2(2), WASF3(2) 13577222 21 21 20 9 0 4 1 11 5 0 0.907 1.000 1.000 320 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 19 APAF1(3), BAK1(1), BID(2), BIK(1), BIRC2(2), BIRC3(5), CASP7(1), CASP8(1), CASP9(2), DFFA(1), DFFB(1), DIABLO(1) 13557694 21 21 21 7 1 4 4 7 5 0 0.628 1.000 1.000 321 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(2), ACOX3(5), FADS2(2), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(4) 10376815 18 18 18 8 3 4 2 7 2 0 0.704 1.000 1.000 322 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 16 CHUK(2), CREBBP(9), EP300(16), IKBKB(3), NFKB1(2), NFKBIA(2), RELA(6), RIPK1(1), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TRADD(2), TRAF6(2) 22330282 48 43 42 11 3 7 7 10 20 1 0.422 1.000 1.000 323 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 32 ABAT(1), ACACA(9), ACACB(5), ACADM(1), ACAT1(1), ACSS1(3), ACSS2(7), ALDH1B1(4), ALDH2(4), ALDH3A2(2), ALDH7A1(1), ECHS1(3), EHHADH(6), HADHA(4), HIBCH(1), LDHAL6B(1), LDHB(2), LDHC(3), MCEE(1), MLYCD(3), MUT(2), PCCA(2), PCCB(3), SUCLA2(2), SUCLG1(6), SUCLG2(2) 38855188 79 70 76 16 4 10 22 21 20 2 0.0747 1.000 1.000 324 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 26 ABAT(1), ACADS(3), ACAT1(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(4), ALDH2(4), ALDH3A2(2), ECHS1(3), EHHADH(6), GAD1(2), GAD2(2), HADHA(4), HMGCL(2), L2HGDH(1), OXCT1(2), PDHA1(1), PDHA2(3), PDHB(1), SDHB(1) 24801031 45 44 43 10 6 8 10 13 8 0 0.122 1.000 1.000 325 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(2), IL4(1), JUNB(2), MAF(2), MAP2K3(3), MAPK14(1), NFATC1(4), NFATC2(8), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3) 11365863 33 31 31 11 7 0 2 14 10 0 0.732 1.000 1.000 326 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 40 AKT1(2), AKT2(5), AKT3(3), BRAF(4), DDIT4(1), EIF4B(5), EIF4EBP1(1), FIGF(1), HIF1A(4), INS(1), MAPK3(3), PGF(2), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PRKAA1(1), RICTOR(7), RPS6KA3(3), RPS6KA6(1), RPS6KB1(2), RPS6KB2(2), STK11(2), TSC1(5), TSC2(12), ULK1(2), ULK2(3), ULK3(3), VEGFA(1), VEGFC(2) 47733502 101 95 98 19 11 17 13 33 22 5 0.0259 1.000 1.000 327 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 33 AKT1(2), APC(9), AR(5), ASAH1(2), BRAF(4), CAMP(1), DAG1(3), EGFR(9), GNA11(1), GNA15(1), GNAI1(2), ITPKA(1), ITPKB(3), ITPR1(7), ITPR2(12), ITPR3(5), KCNJ3(4), MAPK10(2), MAPK14(1), PHKA2(5), PIK3CD(2), PIK3R1(5), PITX2(2), RAF1(4), SRC(3) 51066769 95 79 92 16 10 17 15 32 20 1 0.0145 1.000 1.000 328 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 26 ALDH3B1(4), ALDH3B2(3), AOC2(4), AOC3(2), DDC(3), EPX(3), ESCO1(2), ESCO2(1), GOT1(3), GOT2(2), HPD(2), LPO(1), MAOA(2), MAOB(2), MPO(6), PNPLA3(3), PRDX6(2), SH3GLB1(3), TAT(2), TPO(4) 32788441 54 50 53 10 7 7 11 14 15 0 0.0828 1.000 1.000 329 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 18 CHUK(2), IKBKAP(2), IKBKB(3), LTA(1), MAP3K1(7), NFKB1(2), NFKBIA(2), RELA(6), RIPK1(1), TANK(1), TNFAIP3(2), TNFRSF1B(1), TRAF2(1), TRAF3(1) 22639343 32 29 29 7 3 7 0 9 12 1 0.431 1.000 1.000 330 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 28 AMDHD2(3), CHIA(5), CHIT1(5), CMAS(1), CYB5R1(2), CYB5R3(2), GFPT1(2), GFPT2(1), GNE(1), GNPDA1(1), GNPNAT1(1), HEXA(4), HK1(6), MTMR1(2), MTMR2(3), MTMR6(1), NAGK(3), NANS(3), PHPT1(1), RENBP(4) 28022287 51 48 51 10 7 6 8 17 12 1 0.0831 1.000 1.000 331 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(6), ARHGEF1(2), GNA12(1), GNA13(4), GNB1(3), MYL2(1), MYLK(4), PLCB1(3), PPP1R12B(2), PRKCA(2), ROCK1(5) 20532945 33 33 33 9 3 2 2 17 9 0 0.665 1.000 1.000 332 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(3), CD28(1), CSK(4), CTLA4(3), DAG1(3), DTYMK(1), EPHB2(2), FBXW7(6), GRAP2(1), GRB2(2), ITK(1), ITPKA(1), ITPKB(3), LCK(1), LCP2(3), NCK1(1), NFAT5(8), NFKB1(2), NFKB2(3), NFKBIA(2), NFKBIB(2), NFKBIL1(2), PAK1(3), PAK2(4), PAK3(1), PAK4(3), PAK6(5), PAK7(3), PLCG1(4), PTPRC(8), RAF1(4), RASGRP1(3), RASGRP2(2), RASGRP3(2), RASGRP4(3), SOS1(8), SOS2(7), VAV1(4), ZAP70(1) 55484143 120 99 119 20 13 16 20 40 31 0 0.0101 1.000 1.000 333 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), DAG1(3), ITPKA(1), ITPKB(3), ITPR1(7), ITPR2(12), ITPR3(5), NFAT5(8), PDE6A(1), PDE6B(6), PDE6C(3), SLC6A13(7) 35983094 61 56 61 11 6 7 14 22 12 0 0.0561 1.000 1.000 334 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 26 ABAT(1), ACADL(3), ACADM(1), ACADSB(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(4), ALDH2(4), ALDH3A2(2), AOC2(4), AOC3(2), CNDP1(4), DPYD(5), DPYS(4), ECHS1(3), EHHADH(6), GAD1(2), GAD2(2), HADHA(4), MLYCD(3), SMS(2), UPB1(1) 27746796 60 58 59 15 3 9 15 17 14 2 0.199 1.000 1.000 335 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 40 ACY3(2), ALDH1B1(4), ALDH2(4), ALDH3A2(2), ALDH3B1(4), ALDH3B2(3), ALDH7A1(1), AMDHD1(2), AOC2(4), AOC3(2), ASPA(1), CNDP1(4), DDC(3), FTCD(2), HAL(1), HARS(1), HARS2(1), HDC(1), HNMT(2), LCMT1(1), LCMT2(4), MAOA(2), MAOB(2), METTL2B(1), PRMT2(2), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(2), PRMT8(3), PRPS1(1), PRPS2(4), UROC1(2) 38177979 75 66 74 14 7 14 13 24 17 0 0.0289 1.000 1.000 336 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 37 ACAA1(3), ACAD8(2), ACAD9(2), ADH1A(2), ADH1B(2), ADH4(2), ADH5(1), ADH6(2), ADHFE1(3), AKR1B10(2), AKR1C4(1), ALDH1B1(4), ALDH2(4), ALDH3A2(2), ALDH7A1(1), BAAT(2), CEL(3), CYP27A1(1), HADHB(4), LIPA(1), RDH11(4), RDH13(1), SLC27A5(3), SOAT1(4), SOAT2(3), SRD5A1(1) 30705319 60 56 57 13 6 4 7 26 17 0 0.301 1.000 1.000 337 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(3), ELK1(1), FOS(1), GRB2(2), HRAS(1), IL2RA(2), IL2RB(2), JAK1(6), JAK3(4), JUN(2), LCK(1), MAPK3(3), RAF1(4), SHC1(4), SOS1(8), STAT5A(3), STAT5B(3), SYK(2) 23192421 52 50 51 13 7 7 9 15 14 0 0.358 1.000 1.000 338 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD28(1), CD86(3), HLA-DRA(1), HLA-DRB1(6), IFNGR1(3), IFNGR2(2), IL12RB1(4), IL12RB2(2), IL18R1(1), IL2RA(2), IL4(1), IL4R(4) 12513657 30 28 30 10 5 3 2 9 11 0 0.734 1.000 1.000 339 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 21 CSNK2A1(3), FOS(1), GRB2(2), HRAS(1), JAK2(7), JUN(2), MAPK3(3), PIK3R1(5), PLCG1(4), PRKCA(2), RAF1(4), RASA1(7), SHC1(4), SOS1(8), STAT1(5), STAT3(3), STAT5A(3), STAT5B(3), THPO(1) 27670915 68 61 66 15 7 9 8 25 19 0 0.397 1.000 1.000 340 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 20 CSNK2A1(3), ELK1(1), FOS(1), GRB2(2), HRAS(1), IL6R(2), IL6ST(6), JAK1(6), JAK2(7), JAK3(4), JUN(2), MAPK3(3), PTPN11(2), RAF1(4), SHC1(4), SOS1(8), STAT3(3) 23498579 59 55 59 15 5 7 10 23 14 0 0.449 1.000 1.000 341 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 16 ABCC2(4), ABCG2(2), BCHE(3), CES1(8), CES2(2), CYP3A5(1), UGT1A1(5), UGT1A3(1), UGT1A4(2), UGT1A5(2), UGT1A6(3), UGT1A7(3), UGT1A9(5) 19863911 41 36 39 11 2 3 9 14 13 0 0.616 1.000 1.000 342 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CHUK(2), CREBBP(9), EP300(16), IKBKB(3), IL1B(1), MAP2K3(3), MAP3K7(3), MAPK11(1), MAPK14(1), NFKB1(2), NFKBIA(2), NR3C1(4), RELA(6), TGFBR1(1), TGFBR2(2), TLR2(2), TNF(1) 29534966 59 50 53 12 4 7 7 18 21 2 0.282 1.000 1.000 343 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(2), CHUK(2), IKBKB(3), IL4(1), JUN(2), MAP3K1(7), MAP3K5(5), MAP4K5(4), MAPK14(1), NFKB1(2), NFKBIA(2), RELA(6), TNFRSF9(1), TNFSF9(1), TRAF2(1) 19715506 40 36 37 10 2 5 1 14 17 1 0.777 1.000 1.000 344 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(3), DYRK1B(1), GLI2(4), GLI3(7), GSK3B(3), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), SHH(3), SMO(4), SUFU(3) 15784321 38 35 36 11 5 5 3 13 12 0 0.569 1.000 1.000 345 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 17 CSNK2A1(3), DPM2(1), ELK1(1), FOS(1), GRB2(2), HRAS(1), JUN(2), MAPK3(3), NGFR(1), PIK3R1(5), PLCG1(4), RAF1(4), SHC1(4), SOS1(8) 16551872 40 38 39 11 5 7 4 15 9 0 0.597 1.000 1.000 346 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 23 ATM(19), BMPR1B(2), CCND2(1), CDK4(6), CDKN1B(1), DAZL(2), ESR2(4), FSHR(2), MLH1(3), NCOR1(7), NR5A1(1), NRIP1(5), PGR(5), PRLR(3), PTGER2(1), SMPD1(4), VDR(2), ZP2(6) 33163002 74 63 69 16 9 11 8 23 22 1 0.189 1.000 1.000 347 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 33 GTF2A1(2), GTF2B(2), GTF2E1(1), GTF2E2(3), GTF2F1(1), GTF2F2(1), GTF2H1(2), GTF2H2(1), GTF2H4(1), GTF2I(4), GTF2IRD1(2), STON1(3), TAF1(7), TAF10(1), TAF1L(9), TAF2(6), TAF4(7), TAF4B(8), TAF5(2), TAF5L(3), TAF6(2), TAF7(2), TAF7L(7), TAF9B(2), TBPL2(1) 36296949 80 72 76 17 5 13 13 27 22 0 0.0911 1.000 1.000 348 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(4), IL22RA1(3), IL22RA2(1), JAK1(6), JAK2(7), JAK3(4), SOCS3(1), STAT1(5), STAT3(3), STAT5A(3), STAT5B(3), TYK2(7) 18363912 47 45 45 13 4 0 9 20 14 0 0.801 1.000 1.000 349 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(5), CTH(2), GGT1(4), LCMT1(1), LCMT2(4), MARS(3), MARS2(4), MAT1A(1), MAT2B(1), METTL2B(1), PAPSS1(2), PAPSS2(4), PRMT2(2), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(2), PRMT8(3), SCLY(3), SEPHS1(1), SEPHS2(4) 24467737 54 50 54 14 4 7 14 14 15 0 0.350 1.000 1.000 350 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 ACVR1(1), APC(9), ATF2(2), AXIN1(4), BMP10(1), BMP2(1), BMP4(1), BMP5(1), BMP7(5), BMPR1A(1), BMPR2(5), CHRD(5), CTNNB1(2), DVL1(1), FZD1(3), GATA4(2), GSK3B(3), MAP3K7(3), MYL2(1), NKX2-5(3), NOG(2), NPPA(1), NPPB(1), RFC1(5), TGFB2(2), TGFBR1(1), TGFBR2(2), TGFBR3(3), WNT1(2) 35696562 73 62 71 16 11 6 5 29 21 1 0.221 1.000 1.000 351 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 38 AKT1(2), AKT2(5), AKT3(3), BAD(1), BCR(1), BLNK(1), CD19(1), CSK(4), DAG1(3), EPHB2(2), GRB2(2), ITPKA(1), ITPKB(3), LYN(1), MAP2K2(1), NFAT5(8), NFKB1(2), NFKB2(3), NFKBIA(2), NFKBIB(2), NFKBIL1(2), PI3(1), PIK3CD(2), PIK3R1(5), PLCG2(4), PPP1R13B(4), RAF1(4), SHC1(4), SOS1(8), SOS2(7), SYK(2), VAV1(4) 49441181 95 83 95 17 12 13 16 33 21 0 0.0211 1.000 1.000 352 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 ACHE(1), CHAT(5), DBH(2), DDC(3), GAD1(2), GAD2(2), HDC(1), MAOA(2), PAH(5), SLC18A3(2), TH(4), TPH1(2) 13885177 31 30 29 10 3 5 7 8 8 0 0.669 1.000 1.000 353 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 25 CSNK2A1(3), ELK1(1), FOS(1), GRB2(2), HRAS(1), JAK1(6), JUN(2), MAP3K1(7), MAPK3(3), PDGFRA(6), PIK3R1(5), PLCG1(4), PRKCA(2), RAF1(4), RASA1(7), SHC1(4), SOS1(8), STAT1(5), STAT3(3), STAT5A(3) 32676953 77 69 75 17 9 12 6 25 25 0 0.362 1.000 1.000 354 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAD(1), CASP8(1), MAP3K1(7), MAPK3(3), NFKB1(2), NSMAF(6), RAF1(4), RELA(6), RIPK1(1), SMPD1(4), TNFRSF1A(1), TRADD(2), TRAF2(1) 20354567 39 35 35 10 4 6 6 10 12 1 0.455 1.000 1.000 355 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(8), BST1(2), CD38(1), ENPP1(4), ENPP3(2), NADK(1), NADSYN1(1), NMNAT2(2), NMNAT3(2), NNMT(1), NNT(7), NT5C1A(2), NT5C1B(2), NT5C2(1), NT5M(2), NUDT12(2), QPRT(1) 21512856 41 39 40 11 3 3 4 23 8 0 0.597 1.000 1.000 356 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(8), ACE2(2), AGT(4), AGTR1(2), AGTR2(1), ANPEP(8), CMA1(1), CTSA(1), ENPEP(5), LNPEP(3), MAS1(1), MME(5), REN(1), THOP1(1) 21043556 43 38 39 12 2 6 12 13 10 0 0.583 1.000 1.000 357 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(2), AGT(4), AGTR1(2), AGTR2(1), CMA1(1), COL4A1(3), COL4A2(2), COL4A3(7), COL4A4(4), COL4A5(8), COL4A6(7), REN(1) 25559695 42 39 42 12 4 12 5 16 5 0 0.300 1.000 1.000 358 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 CISH(2), IL6R(2), JAK1(6), JAK2(7), JAK3(4), PIAS3(3), PTPRU(4), SRC(3), STAT3(3) 15110643 34 30 34 10 2 4 5 13 10 0 0.732 1.000 1.000 359 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 61 APAF1(3), ATM(19), ATR(12), BAI1(5), BID(2), CASP8(1), CASP9(2), CCNB1(1), CCNB2(6), CCNB3(4), CCND2(1), CCNE1(2), CCNE2(4), CCNG1(1), CCNG2(2), CD82(3), CDK2(2), CDK4(6), CDK6(1), CDKN1A(3), CHEK1(1), CHEK2(2), FAS(2), GADD45B(1), GTSE1(4), IGFBP3(1), PERP(1), PPM1D(2), RCHY1(3), RFWD2(3), RRM2(1), SERPINB5(5), SESN1(2), SFN(1), STEAP3(2), TNFRSF10B(1), TP53I3(4), TP73(4), TSC2(12), ZMAT3(1) 60299984 133 109 127 25 16 22 18 33 42 2 0.0157 1.000 1.000 360 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 21 AKT1(2), BCR(1), CRKL(1), FOS(1), GRB2(2), HRAS(1), JAK2(7), JUN(2), MAP3K1(7), MAPK3(3), MYC(1), PIK3R1(5), RAF1(4), SOS1(8), STAT1(5), STAT5A(3), STAT5B(3) 25443827 56 53 55 14 5 7 7 23 14 0 0.499 1.000 1.000 361 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(4), AGTR2(1), CALM2(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), F2(3), FYN(2), GNA11(1), GNAI1(2), GNB1(3), GRB2(2), HRAS(1), JAK2(7), MAP2K2(1), MAPK14(1), MAPK3(3), MAPT(4), MYLK(4), PLCG1(4), PRKCA(2), PTK2B(3), RAF1(4), SHC1(4), SOS1(8), STAT1(5), STAT3(3), STAT5A(3), SYT1(1) 41878239 82 72 80 17 6 11 11 33 21 0 0.216 1.000 1.000 362 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 19 CSNK2A1(3), ELK1(1), FOS(1), GRB2(2), HRAS(1), IGF1R(3), IRS1(5), JUN(2), MAPK3(3), PIK3R1(5), PTPN11(2), RAF1(4), RASA1(7), SHC1(4), SOS1(8) 22005737 51 47 51 14 9 11 3 17 11 0 0.403 1.000 1.000 363 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 44 ACAA1(3), ACADL(3), ACADM(1), ACADS(3), ACADSB(1), ACAT1(1), ACOX1(2), ACOX3(5), ACSL1(4), ACSL4(1), ACSL5(1), ACSL6(5), ADH1A(2), ADH1B(2), ADH4(2), ADH5(1), ADH6(2), ADHFE1(3), ALDH1B1(4), ALDH2(4), ALDH3A2(2), ALDH7A1(1), CPT1A(2), CPT1C(4), CPT2(2), CYP4A11(5), CYP4A22(1), ECHS1(3), EHHADH(6), HADH(1), HADHA(4), HADHB(4), HSD17B4(1) 45701714 86 81 81 19 7 13 17 31 17 1 0.0907 1.000 1.000 364 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 22 CHUK(2), IKBKB(3), IL1R1(3), IRAK1(3), MAP3K1(7), MAP3K7(3), NFKB1(2), NFKBIA(2), RELA(6), RIPK1(1), TLR4(3), TNF(1), TNFAIP3(2), TNFRSF1A(1), TNFRSF1B(1), TRADD(2), TRAF6(2) 24297343 44 38 41 11 5 10 3 9 15 2 0.427 1.000 1.000 365 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP1(1), ACP2(1), ACP5(2), ALPI(3), ALPL(4), ALPP(5), ALPPL2(5), CYP19A1(2), CYP1A1(1), CYP1A2(4), CYP2A13(5), CYP2A6(4), CYP2A7(2), CYP2B6(1), CYP2C18(1), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP2D6(4), CYP2E1(1), CYP2F1(4), CYP2J2(3), CYP3A5(1), CYP3A7(2), CYP4B1(3), CYP51A1(2) 28654943 64 54 64 16 13 12 3 25 11 0 0.156 1.000 1.000 366 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 29 ACY1(3), AGMAT(2), ALDH18A1(2), ALDH1B1(4), ALDH2(4), ALDH3A2(2), ALDH7A1(1), AMD1(2), AOC2(4), AOC3(2), ARG1(1), ARG2(1), ASL(4), ASS1(3), CPS1(5), GATM(1), MAOA(2), MAOB(2), NAGS(1), ODC1(2), OTC(1), SAT1(1), SAT2(1), SMS(2) 28273900 53 51 53 13 3 7 11 18 14 0 0.317 1.000 1.000 367 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 27 ADRBK1(2), AKT1(2), AKT2(5), AKT3(3), DAG1(3), ITPKA(1), ITPKB(3), ITPR1(7), ITPR2(12), ITPR3(5), NFKB1(2), NFKB2(3), NFKBIA(2), NFKBIB(2), NFKBIL1(2), PDK1(1), PHKA2(5), PIK3CB(5), PITX2(2), PLD1(2), PLD2(5), PLD3(3) 44709441 77 66 75 15 11 12 13 24 17 0 0.0308 1.000 1.000 368 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 15 AKT1(2), MAP2K2(1), MAP2K3(3), MAP3K1(7), MAPK14(1), MAPK3(3), NFKB1(2), PIK3R1(5), RB1(4), RELA(6), SP1(2) 17485075 36 34 33 10 2 6 1 13 11 3 0.808 1.000 1.000 369 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(1), ALDH4A1(2), CAD(12), CPS1(5), EPRS(4), GAD1(2), GAD2(2), GCLC(4), GFPT1(2), GFPT2(1), GLS(6), GLS2(4), GLUD2(7), GLUL(2), GMPS(1), GNPNAT1(1), GOT1(3), GOT2(2), GPT(4), GPT2(2), GSR(1), GSS(1), NADSYN1(1), NAGK(3), PPAT(3), QARS(1) 39509883 77 67 71 17 7 8 17 26 18 1 0.227 1.000 1.000 370 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 17 DNAJA3(1), IFNGR1(3), IFNGR2(2), IKBKB(3), JAK2(7), NFKB1(2), NFKBIA(2), RB1(4), RELA(6), TNF(1), TNFRSF1A(1), TNFRSF1B(1), USH1C(4), WT1(3) 17377959 40 37 37 12 2 4 3 12 16 3 0.903 1.000 1.000 371 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 26 ACAA1(3), ADH1A(2), ADH1B(2), ADH4(2), ADH6(2), ADHFE1(3), AKR1C4(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(4), ALDH2(4), ALDH3A2(2), BAAT(2), CEL(3), CYP27A1(1), HADHB(4), SOAT2(3), SRD5A1(1) 22244139 41 39 40 12 4 3 6 18 10 0 0.675 1.000 1.000 372 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 25 AKT1(2), AKT2(5), AKT3(3), CISH(2), GRB2(2), IARS(4), IL13RA1(2), IL4(1), IL4R(4), INPP5D(2), JAK1(6), JAK2(7), JAK3(4), PI3(1), PPP1R13B(4), RPS6KB1(2), SHC1(4), SOS1(8), SOS2(7), SRC(3), STAT6(5), TYK2(7) 34349153 85 71 84 20 7 12 16 29 21 0 0.211 1.000 1.000 373 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 79 AIFM1(6), AKT1(2), AKT2(5), AKT3(3), APAF1(3), ATM(19), BAD(1), BID(2), BIRC2(2), BIRC3(5), CAPN1(2), CAPN2(4), CASP10(3), CASP7(1), CASP8(1), CASP9(2), CFLAR(1), CHUK(2), CSF2RB(5), DFFA(1), DFFB(1), FAS(2), FASLG(2), IKBKB(3), IL1B(1), IL1R1(3), IL1RAP(4), IL3(1), IRAK1(3), IRAK3(4), IRAK4(1), NFKB1(2), NFKB2(3), NFKBIA(2), NTRK1(7), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PPP3CA(3), PPP3CC(3), PRKACA(2), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), RELA(6), RIPK1(1), TNF(1), TNFRSF10B(1), TNFRSF10C(2), TNFRSF1A(1), TRADD(2), TRAF2(1) 80167084 165 134 158 29 18 22 20 62 42 1 0.00803 1.000 1.000 374 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 21 ACAD8(2), ACAD9(2), ADH1A(2), ADH1B(2), ADH4(2), ADH5(1), ADH6(2), ADHFE1(3), DHRS2(1), ESCO1(2), ESCO2(1), PNPLA3(3), SH3GLB1(3) 24325921 26 25 25 8 1 3 2 13 7 0 0.793 1.000 1.000 375 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 29 A1BG(1), AKT1(2), AKT2(5), AKT3(3), BAD(1), DAPP1(2), GRB2(2), GSK3A(2), GSK3B(3), IARS(4), IGFBP1(1), INPP5D(2), PDK1(1), PPP1R13B(4), RPS6KA3(3), RPS6KB1(2), SFN(1), SHC1(4), SOS1(8), SOS2(7), TEC(5), YWHAB(1) 30929354 64 60 62 16 4 12 12 18 18 0 0.287 1.000 1.000 376 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 AGXT(2), AGXT2(1), AKR1B10(2), ALAS1(5), ALAS2(5), AOC2(4), AOC3(2), BHMT(7), CHDH(4), CHKB(2), CTH(2), DAO(1), DLD(4), DMGDH(4), GATM(1), GLDC(4), GNMT(1), MAOA(2), MAOB(2), PHGDH(3), PIPOX(2), PISD(1), PSAT1(2), RDH11(4), RDH13(1), SARDH(4), SARS(2), SHMT1(2), SHMT2(5), TARS(5), TARS2(7) 42587499 93 85 89 22 11 14 14 27 26 1 0.169 1.000 1.000 377 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(1), IARS(4), IARS2(3), ILVBL(3), LARS(7), LARS2(2), PDHA1(1), PDHA2(3), PDHB(1), VARS(4), VARS2(6) 17577080 35 31 35 10 2 7 6 11 9 0 0.457 1.000 1.000 378 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 23 ABL1(8), ATM(19), ATR(12), CCNA1(7), CCNE1(2), CDC25A(1), CDK2(2), CDK4(6), CDK6(1), CDKN1A(3), CDKN1B(1), E2F1(1), GSK3B(3), HDAC1(2), RB1(4), SKP2(1), TGFB2(2) 28773590 75 62 66 19 4 8 9 19 32 3 0.536 1.000 1.000 379 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 20 CFL1(1), CHN1(2), MAP3K1(7), MYL2(1), MYLK(4), NCF2(1), PAK1(3), PDGFRA(6), PIK3R1(5), PLD1(2), PPP1R12B(2), RALBP1(2), RPS6KB1(2), TRIO(9), VAV1(4), WASF1(1) 31689250 52 50 52 12 3 5 5 22 17 0 0.555 1.000 1.000 380 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 20 ATM(19), ATR(12), BRCA1(7), CCNB1(1), CDC25A(1), CDC25B(1), CDC25C(3), CDKN1A(3), CHEK1(1), CHEK2(2), EP300(16), MYT1(5), PRKDC(12), WEE1(2) 40678957 85 72 81 18 3 11 10 34 26 1 0.214 1.000 1.000 381 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 17 CALM2(1), CDKN1A(3), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), PLCG1(4), PPP3CA(3), PPP3CC(3), PRKCA(2), SP1(2), SP3(2), SYT1(1) 20011083 43 38 40 13 5 5 3 10 19 1 0.831 1.000 1.000 382 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1C4(1), ARSB(1), ARSD(2), ARSE(2), CYP11B1(4), CYP11B2(2), HSD11B2(1), HSD17B2(1), HSD17B8(1), HSD3B1(1), SRD5A1(1), SULT1E1(2), SULT2A1(1), UGT1A1(5), UGT1A3(1), UGT1A4(2), UGT1A5(2), UGT1A6(3), UGT1A7(3), UGT1A9(5), UGT2B15(1), UGT2B4(4) 27033091 46 42 46 13 3 3 11 12 17 0 0.451 1.000 1.000 383 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 44 AADAC(1), ABAT(1), ACADS(3), ACAT1(1), ACSM1(3), AKR1B10(2), ALDH1B1(4), ALDH2(4), ALDH3A2(2), ALDH7A1(1), BDH1(1), BDH2(1), DDHD1(2), ECHS1(3), EHHADH(6), GAD1(2), GAD2(2), HADH(1), HADHA(4), HMGCL(2), HMGCS1(2), HMGCS2(1), HSD17B4(1), ILVBL(3), L2HGDH(1), OXCT1(2), PDHA1(1), PDHA2(3), PDHB(1), PLA1A(3), PRDX6(2), RDH11(4), RDH13(1) 39693909 71 66 69 17 8 11 13 24 15 0 0.180 1.000 1.000 384 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(2), GPLD1(2), PGAP1(6), PIGB(2), PIGC(1), PIGG(1), PIGK(1), PIGL(2), PIGM(2), PIGN(3), PIGO(5), PIGP(1), PIGQ(4), PIGS(1), PIGT(6), PIGU(1), PIGV(1), PIGZ(3) 24309100 44 41 40 13 3 8 4 16 12 1 0.638 1.000 1.000 385 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGT(4), AGTR1(2), ATF2(2), CALM2(1), EGFR(9), ELK1(1), GRB2(2), HRAS(1), JUN(2), MAP2K2(1), MAP3K1(7), MAPK3(3), MEF2A(2), MEF2D(1), PAK1(3), PRKCA(2), PTK2(3), PTK2B(3), RAF1(4), SHC1(4), SOS1(8), SRC(3), SYT1(1) 33840107 69 61 67 17 6 15 8 23 17 0 0.325 1.000 1.000 386 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(2), ALOX12(3), ALOX5(4), CBR1(4), CYP4F2(4), CYP4F3(2), EPX(3), GGT1(4), LPO(1), LTA4H(4), MPO(6), PLA2G4A(2), PLA2G6(4), PRDX1(1), PRDX5(1), PRDX6(2), PTGDS(1), PTGS1(2), PTGS2(5), TBXAS1(4), TPO(4) 27591028 63 58 61 17 7 6 16 18 15 1 0.420 1.000 1.000 387 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 21 ARHGAP5(6), DIAPH1(7), FYN(2), GSN(5), HRAS(1), ITGA1(8), ITGB1(7), MAPK3(3), MYL2(1), MYLK(4), PIK3R1(5), PTK2(3), PXN(3), RAF1(4), ROCK1(5), SHC1(4), SRC(3), TLN1(13) 35169158 84 74 83 20 6 10 9 30 29 0 0.459 1.000 1.000 388 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(1), AKT1(2), BDKRB2(1), CALM2(1), CHRM1(2), CHRNA1(3), FLT1(8), FLT4(14), KDR(6), NOS3(3), PDE2A(3), PDE3A(3), PDE3B(3), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PRKG1(4), PRKG2(3), RYR2(17), SLC7A1(3), SYT1(1), TNNI1(2) 41123979 90 81 90 22 16 15 8 33 18 0 0.126 1.000 1.000 389 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 13 ABL1(8), E2F1(1), MYC(1), PIK3R1(5), POLR1A(6), POLR1B(4), POLR1C(2), POLR1D(1), RB1(4) 16343092 32 29 32 10 2 6 1 12 9 2 0.758 1.000 1.000 390 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 55 ADH1A(2), ADH1B(2), ADH4(2), ADH5(1), ADH6(2), ADHFE1(3), ALDH3B1(4), ALDH3B2(3), AOC2(4), AOC3(2), AOX1(8), DBH(2), DCT(4), DDC(3), ECH1(2), ESCO1(2), ESCO2(1), FAH(1), GOT1(3), GOT2(2), HGD(3), HPD(2), LCMT1(1), LCMT2(4), MAOA(2), MAOB(2), METTL2B(1), PNPLA3(3), PRMT2(2), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(2), PRMT8(3), SH3GLB1(3), TAT(2), TH(4), TPO(4), TYR(5), TYRP1(4) 57842860 107 91 105 23 12 11 15 38 31 0 0.139 1.000 1.000 391 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(4), AP2A1(3), AP2M1(1), BIN1(3), CALM2(1), DNM1(4), EPN1(1), EPS15(2), PICALM(3), PPP3CA(3), PPP3CC(3), SYNJ1(6), SYNJ2(5), SYT1(1) 22148223 40 39 40 12 2 6 7 14 11 0 0.569 1.000 1.000 392 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 40 ALG1(1), ALG10(3), ALG10B(8), ALG11(4), ALG12(2), ALG13(5), ALG14(1), ALG3(3), ALG5(2), ALG6(3), ALG8(1), ALG9(2), B4GALT1(1), B4GALT3(2), DOLPP1(3), DPM1(1), MAN1A1(2), MAN1A2(1), MAN1B1(1), MAN2A1(3), MGAT2(1), MGAT3(1), MGAT4A(3), MGAT4B(1), MGAT5(4), MGAT5B(4), RFT1(1), RPN1(3), RPN2(1), ST6GAL1(1), STT3B(4) 41266086 73 60 72 16 4 14 4 24 27 0 0.255 1.000 1.000 393 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 25 ALDOA(2), ALDOB(3), ALDOC(1), G6PD(2), H6PD(3), PFKL(3), PFKM(3), PFKP(3), PGM1(1), PRPS1(1), PRPS1L1(2), PRPS2(4), RBKS(1), RPE(2), RPIA(2), TALDO1(1), TKT(2), TKTL1(2), TKTL2(5) 22799459 43 43 43 13 6 8 6 12 11 0 0.549 1.000 1.000 394 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(9), ASAH1(2), CAMP(1), CERK(6), CREB5(3), DAG1(3), EPHB2(2), FOS(1), ITPKA(1), ITPKB(3), JUN(2), MAP2K7(1), MAPK10(2), MAPK8IP1(4), MAPK8IP2(1), MAPK8IP3(2), MAPK9(2) 27735983 45 41 42 12 7 4 7 13 14 0 0.569 1.000 1.000 395 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 21 ACTA1(1), ADCY1(2), CCNB1(1), CDC25C(3), GNAI1(2), GNAS(6), GNB1(3), HRAS(1), MAPK3(3), MYT1(5), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), SRC(3) 18578089 40 38 40 12 5 6 3 20 6 0 0.545 1.000 1.000 396 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(8), CD2(2), CD33(3), CD5(1), IFNA1(1), IFNB1(2), IL3(1), IL4(1), ITGAX(8), TLR2(2), TLR4(3), TLR7(5), TLR9(1) 18230793 38 36 37 12 5 4 9 11 9 0 0.541 1.000 1.000 397 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 44 AADAT(2), AASDHPPT(3), AASS(8), ACAT1(1), AKR1B10(2), ALDH1B1(4), ALDH2(4), ALDH3A2(2), ALDH7A1(1), BBOX1(1), DOT1L(9), ECHS1(3), EHHADH(6), EHMT1(4), EHMT2(8), HADH(1), HADHA(4), HSD17B4(1), NSD1(13), OGDH(8), OGDHL(2), PIPOX(2), PLOD1(2), PLOD2(5), RDH11(4), RDH13(1), SETD1A(8), SETD7(1), SETDB1(6), SHMT1(2), SHMT2(5), SPCS1(2), SUV39H2(5), TMLHE(1) 53636779 131 111 128 29 10 22 20 47 32 0 0.0883 1.000 1.000 398 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(6), ADRBK2(2), ARRB2(1), CALM2(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CLCA1(3), CLCA4(2), CNGA3(4), CNGA4(3), CNGB1(6), GUCA1B(1), PDC(1), PDE1C(2), PRKACA(2), PRKACB(2), PRKACG(2), PRKG1(4), PRKG2(3), PRKX(2) 30876627 52 50 49 14 8 6 4 22 12 0 0.463 1.000 1.000 399 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 12 CREBBP(9), DAXX(6), HRAS(1), PAX3(2), PML(2), RARA(4), RB1(4), SIRT1(5), SP100(2), TNF(1), TNFRSF1A(1), TNFRSF1B(1) 17648356 38 37 38 12 5 4 5 10 12 2 0.727 1.000 1.000 400 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(9), EP300(16), LPL(3), NCOA1(3), NCOA2(11), PPARG(2) 18385145 44 36 35 14 3 4 5 11 21 0 0.712 1.000 1.000 401 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 50 ACTA1(1), AGT(4), AKT1(2), CALM2(1), CALR(2), CAMK1(3), CAMK1G(3), CAMK4(3), CREBBP(9), CSNK1A1(2), ELSPBP1(2), F2(3), GATA4(2), GSK3B(3), HAND2(1), HRAS(1), MAPK14(1), MAPK3(3), MYH2(9), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), NKX2-5(3), NPPA(1), PIK3R1(5), PPP3CA(3), PPP3CC(3), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), RAF1(4), RPS6KB1(2), SYT1(1) 47536759 109 92 104 27 14 11 9 35 40 0 0.363 1.000 1.000 402 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 36 ACACA(9), ACAT1(1), ADH5(1), AKR1B1(3), ALDH1A1(1), ALDH1A2(1), ALDH1B1(4), ALDH2(4), ALDH3A2(2), DLAT(2), DLD(4), GLO1(1), GRHPR(2), HAGH(1), LDHB(2), LDHC(3), MDH1(2), MDH2(1), ME1(1), ME2(3), ME3(2), PC(8), PCK1(5), PDHA1(1), PDHA2(3), PDHB(1), PKLR(1) 35734439 69 61 68 18 4 9 14 18 23 1 0.414 1.000 1.000 403 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(3), COL4A2(2), COL4A3(7), COL4A4(4), COL4A5(8), COL4A6(7), P4HB(3), SLC23A1(6), SLC23A2(2), SLC2A1(2), SLC2A3(2) 25533935 46 42 46 16 4 12 4 17 9 0 0.671 1.000 1.000 404 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CALM2(1), CHUK(2), EGR2(1), EGR3(2), MAP3K1(7), MYC(1), NFATC1(4), NFATC2(8), NFKB1(2), NFKBIA(2), PLCG1(4), PPP3CA(3), PPP3CC(3), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), RELA(6), SYT1(1), VIPR2(2) 27229521 59 54 53 17 8 6 1 17 26 1 0.778 1.000 1.000 405 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 54 ADH1A(2), ADH1B(2), ADH4(2), ADH5(1), ADH6(2), ADHFE1(3), AGK(6), AGPAT1(1), AKR1A1(2), AKR1B1(3), ALDH1B1(4), ALDH2(4), ALDH3A2(2), ALDH7A1(1), CEL(3), DAK(3), DGAT1(2), DGAT2(1), DGKA(4), DGKB(3), DGKD(3), DGKE(5), DGKG(5), DGKH(6), DGKI(1), DGKQ(3), DGKZ(5), GK(1), GK2(3), GLA(1), GLB1(5), GPAM(5), LCT(7), LIPA(1), LIPC(1), LIPF(1), LPL(3), PNLIP(4), PNPLA3(3), PPAP2B(1), PPAP2C(3) 57846106 118 101 117 28 14 16 16 42 30 0 0.106 1.000 1.000 406 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(1), CAPN1(2), CAPN2(4), EGF(5), EGFR(9), HRAS(1), ITGA1(8), ITGB1(7), MAPK3(3), MYL2(1), MYLK(4), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PTK2(3), PXN(3), TLN1(13) 32783740 74 66 71 20 8 7 6 30 23 0 0.582 1.000 1.000 407 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 27 AGA(1), ARSB(1), FUCA1(2), FUCA2(1), GALNS(6), GBA(3), GLB1(5), GNS(4), GUSB(5), HEXA(4), HGSNAT(3), HPSE(2), HPSE2(4), HYAL1(2), HYAL2(1), IDS(2), LCT(7), MAN2B1(1), MAN2B2(2), MAN2C1(5), MANBA(2), NAGLU(2), NEU1(1) 32184866 66 56 66 18 8 9 9 26 14 0 0.320 1.000 1.000 408 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 22 ALDOA(2), ALDOB(3), ALDOC(1), G6PD(2), H6PD(3), PFKM(3), PFKP(3), PGM1(1), PRPS1(1), PRPS1L1(2), PRPS2(4), RBKS(1), RPE(2), RPIA(2), TAL1(3), TALDO1(1), TKT(2) 18740246 36 35 36 12 5 5 6 10 10 0 0.723 1.000 1.000 409 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT1(2), AKT2(5), AKT3(3), ANKRD6(2), APC(9), AXIN1(4), AXIN2(1), CSNK1A1(2), CTNNB1(2), DACT1(2), DVL1(1), FSTL1(2), GSK3A(2), GSK3B(3), LRP1(12), MVP(5), NKD1(4), NKD2(4), PTPRA(5), SENP2(1), WIF1(5) 40007373 76 68 71 19 6 12 11 25 22 0 0.284 1.000 1.000 410 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 15 CREBBP(9), EP300(16), FYN(2), IL7R(1), JAK1(6), JAK3(4), LCK(1), PIK3R1(5), PTK2B(3), STAT5A(3), STAT5B(3) 25759416 53 49 49 15 4 6 10 15 18 0 0.624 1.000 1.000 411 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 41 CALM2(1), CD3E(1), CD3G(2), ELK1(1), FOS(1), FYN(2), GRB2(2), HRAS(1), JUN(2), LCK(1), MAP3K1(7), MAPK3(3), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), NFKB1(2), NFKBIA(2), PIK3R1(5), PLCG1(4), PPP3CA(3), PPP3CC(3), PRKCA(2), PTPN7(1), RAF1(4), RASA1(7), RELA(6), SHC1(4), SOS1(8), SYT1(1), VAV1(4), ZAP70(1) 44851586 103 90 97 25 12 17 8 31 34 1 0.454 1.000 1.000 412 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 35 ANAPC1(4), ANAPC10(1), ANAPC2(2), ANAPC4(6), ANAPC5(3), ANAPC7(2), BTRC(2), CDC16(4), CDC20(3), CDC23(2), CUL1(5), CUL2(4), FBXW11(2), FBXW7(6), FZR1(3), ITCH(1), RBX1(1), SKP2(1), SMURF1(1), SMURF2(3), TCEB2(1), UBA1(4), UBE2D1(2), UBE2D2(1), UBE2D3(2), UBE2E2(1), WWP1(8), WWP2(4) 36973769 79 74 75 19 7 7 16 24 24 1 0.327 1.000 1.000 413 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 28 ACTR2(2), ARHGAP1(1), ARHGAP5(6), ARHGAP6(2), ARHGEF1(2), ARHGEF11(5), ARHGEF5(3), ARPC1B(1), BAIAP2(2), CFL1(1), DIAPH1(7), GSN(5), MYL2(1), MYLK(4), OPHN1(2), PIP5K1A(2), PIP5K1B(1), PPP1R12B(2), ROCK1(5), SRC(3), TLN1(13), VCL(2) 43752436 72 65 71 15 3 8 9 25 27 0 0.323 1.000 1.000 414 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 187 ACTG1(4), ACTN1(1), ACTN2(3), ACTN4(3), AKT1(2), AKT2(5), AKT3(3), ARHGAP5(6), BAD(1), BCAR1(6), BIRC2(2), BIRC3(5), BRAF(4), CAPN2(4), CAV2(2), CAV3(1), CCND2(1), CDC42(1), CHAD(3), COL11A1(9), COL11A2(5), COL1A1(6), COL1A2(10), COL2A1(6), COL3A1(3), COL4A1(3), COL4A2(2), COL4A4(4), COL4A6(7), COL5A1(8), COL5A2(6), COL5A3(12), COL6A1(3), COL6A2(7), COL6A3(20), COL6A6(17), CRKL(1), CTNNB1(2), DIAPH1(7), DOCK1(3), EGF(5), EGFR(9), ELK1(1), ERBB2(8), FARP2(3), FIGF(1), FLNA(6), FLNB(7), FLNC(10), FLT1(8), FN1(8), FYN(2), GRB2(2), GSK3B(3), HGF(1), HRAS(1), IBSP(1), IGF1R(3), ILK(4), ITGA1(8), ITGA10(4), ITGA11(6), ITGA2(4), ITGA2B(1), ITGA3(6), ITGA4(3), ITGA5(5), ITGA6(6), ITGA7(6), ITGA8(3), ITGA9(3), ITGAV(1), ITGB1(7), ITGB3(3), ITGB4(7), ITGB5(6), ITGB6(2), ITGB7(4), ITGB8(1), JUN(2), KDR(6), LAMA1(11), LAMA2(9), LAMA3(10), LAMA4(9), LAMA5(9), LAMB1(16), LAMB2(7), LAMB3(4), LAMB4(5), LAMC1(5), LAMC2(6), LAMC3(8), MAPK10(2), MAPK3(3), MAPK9(2), MYL2(1), MYL7(2), MYL9(1), MYLK(4), MYLK2(1), PAK1(3), PAK2(4), PAK3(1), PAK4(3), PAK6(5), PAK7(3), PARVA(1), PARVB(1), PARVG(2), PDGFC(1), PDGFD(4), PDGFRA(6), PDGFRB(3), PGF(2), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PIP5K1C(4), PPP1CA(1), PPP1CC(2), PPP1R12A(3), PRKCA(2), PRKCG(6), PTK2(3), PXN(3), RAC2(1), RAC3(1), RAF1(4), RAP1A(1), RAPGEF1(5), RELN(7), ROCK1(5), ROCK2(3), SHC1(4), SHC2(4), SHC3(1), SHC4(1), SOS1(8), SOS2(7), SPP1(3), SRC(3), THBS2(3), THBS3(5), THBS4(2), TLN1(13), TLN2(11), TNC(13), TNN(2), TNR(9), TNXB(11), VAV1(4), VAV2(4), VAV3(1), VCL(2), VEGFA(1), VEGFC(2), VTN(1), VWF(15), ZYX(1) 358915253 734 391 717 206 77 95 91 260 206 5 0.262 1.000 1.000 415 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 167 ADCY1(2), ADCY2(7), ADCY3(6), ADCY4(3), ADCY7(1), ADCY8(12), ADCY9(7), ADORA2A(5), ADORA2B(1), ADRA1A(4), ADRB2(2), AGTR1(2), ATP2A1(7), ATP2A2(7), ATP2A3(5), ATP2B1(4), ATP2B3(2), ATP2B4(4), AVPR1A(1), BDKRB1(1), BDKRB2(1), BST1(2), CACNA1A(14), CACNA1B(5), CACNA1C(17), CACNA1D(9), CACNA1E(3), CACNA1F(4), CACNA1G(10), CACNA1H(7), CACNA1I(6), CACNA1S(14), CALM2(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(3), CCKAR(4), CCKBR(3), CD38(1), CHRM1(2), CHRM2(6), CHRM3(3), CHRM5(2), CHRNA7(2), CYSLTR1(1), DRD1(1), EDNRB(3), EGFR(9), ERBB2(8), ERBB3(6), ERBB4(10), F2R(2), GNA11(1), GNA15(1), GNAS(6), GRIN1(2), GRIN2A(8), GRIN2D(2), GRM1(4), GRM5(8), GRPR(2), HRH2(1), HTR2A(1), HTR2B(1), HTR2C(1), HTR4(2), HTR6(2), HTR7(2), ITPKA(1), ITPKB(3), ITPR1(7), ITPR2(12), ITPR3(5), LTB4R2(1), MYLK(4), MYLK2(1), NOS1(10), NOS3(3), NTSR1(3), OXTR(1), P2RX1(3), P2RX2(4), P2RX3(3), P2RX5(1), P2RX7(2), PDE1A(1), PDE1B(5), PDE1C(2), PDGFRA(6), PDGFRB(3), PHKA1(10), PHKA2(5), PHKB(4), PHKG1(3), PHKG2(1), PLCB1(3), PLCB2(4), PLCB3(3), PLCB4(5), PLCD1(3), PLCD3(1), PLCD4(3), PLCE1(6), PLCG1(4), PLCG2(4), PLCZ1(3), PPID(1), PPP3CA(3), PPP3CC(3), PRKACA(2), PRKACB(2), PRKACG(2), PRKCA(2), PRKCG(6), PRKX(2), PTAFR(1), PTGFR(5), PTK2B(3), RYR1(23), RYR2(17), RYR3(18), SLC25A4(2), SLC25A5(3), SLC25A6(2), SLC8A1(3), SLC8A2(3), SLC8A3(4), SPHK1(1), SPHK2(1), TACR1(1), TACR2(1), TACR3(2), TBXA2R(4), TRHR(2), TRPC1(3), VDAC2(1), VDAC3(2) 269778931 559 349 543 164 99 74 59 198 129 0 0.179 1.000 1.000 416 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 245 ACVR1B(3), ACVR1C(3), AKT1(2), AKT2(5), AKT3(3), ARRB1(3), ARRB2(1), ATF2(2), ATF4(2), BDNF(2), BRAF(4), CACNA1A(14), CACNA1B(5), CACNA1C(17), CACNA1D(9), CACNA1E(3), CACNA1F(4), CACNA1G(10), CACNA1H(7), CACNA1I(6), CACNA1S(14), CACNA2D1(6), CACNA2D4(4), CACNB1(4), CACNB2(1), CACNB4(2), CACNG2(2), CACNG3(2), CACNG4(1), CACNG5(1), CACNG6(1), CACNG7(1), CACNG8(1), CDC25B(1), CDC42(1), CHUK(2), CRKL(1), DAXX(6), DUSP10(1), DUSP16(1), DUSP3(2), DUSP4(1), DUSP5(1), DUSP6(2), DUSP8(1), DUSP9(2), ECSIT(5), EGF(5), EGFR(9), ELK1(1), ELK4(2), FAS(2), FASLG(2), FGF1(2), FGF10(2), FGF11(1), FGF12(1), FGF13(1), FGF14(1), FGF19(2), FGF20(1), FGF21(1), FGF3(4), FGF6(4), FGF7(2), FGFR1(6), FGFR2(4), FGFR3(7), FGFR4(3), FLNA(6), FLNB(7), FLNC(10), FOS(1), GADD45B(1), GNA12(1), GNG12(1), GRB2(2), HRAS(1), IKBKB(3), IL1B(1), IL1R1(3), IL1R2(8), JUN(2), KRAS(3), MAP2K2(1), MAP2K3(3), MAP2K5(3), MAP2K7(1), MAP3K1(7), MAP3K10(4), MAP3K12(4), MAP3K13(2), MAP3K2(2), MAP3K3(2), MAP3K4(7), MAP3K5(5), MAP3K6(3), MAP3K7(3), MAP3K8(1), MAP4K1(4), MAP4K3(6), MAP4K4(2), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(3), MAPK7(4), MAPK8IP1(4), MAPK8IP2(1), MAPK8IP3(2), MAPK9(2), MAPKAPK2(1), MAPT(4), MAX(5), MKNK1(2), MKNK2(1), MOS(1), MRAS(1), MYC(1), NF1(12), NFATC2(8), NFATC4(3), NFKB1(2), NFKB2(3), NLK(1), NR4A1(1), NRAS(2), NTRK1(7), NTRK2(2), PAK1(3), PAK2(4), PDGFRA(6), PDGFRB(3), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(4), PPM1A(2), PPM1B(3), PPP3CA(3), PPP3CC(3), PPP5C(2), PRKACA(2), PRKACB(2), PRKACG(2), PRKCA(2), PRKCG(6), PRKX(2), PTPN5(4), PTPN7(1), PTPRR(4), RAC2(1), RAC3(1), RAF1(4), RAP1A(1), RAPGEF2(8), RASA1(7), RASA2(2), RASGRF1(8), RASGRF2(4), RASGRP1(3), RASGRP2(2), RASGRP3(2), RASGRP4(3), RPS6KA3(3), RPS6KA4(2), RPS6KA5(2), RPS6KA6(1), SOS1(8), SOS2(7), STK3(1), TAOK2(3), TAOK3(2), TGFB2(2), TGFBR1(1), TGFBR2(2), TNF(1), TNFRSF1A(1), TRAF2(1), TRAF6(2), ZAK(4) 284905674 576 346 564 157 73 78 72 207 143 3 0.171 1.000 1.000 417 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 198 ABI2(2), ACTN1(1), ACTN2(3), ACTN4(3), APC(9), APC2(5), ARAF(1), ARHGEF1(2), ARHGEF12(5), ARHGEF4(2), ARHGEF6(4), ARHGEF7(5), ARPC1B(1), ARPC5L(1), BAIAP2(2), BCAR1(6), BDKRB1(1), BDKRB2(1), BRAF(4), CDC42(1), CFL1(1), CFL2(1), CHRM1(2), CHRM2(6), CHRM3(3), CHRM5(2), CRKL(1), CSK(4), CYFIP1(7), CYFIP2(6), DIAPH1(7), DIAPH2(2), DIAPH3(7), DOCK1(3), EGF(5), EGFR(9), EZR(2), F2(3), F2R(2), FGD1(2), FGD3(1), FGF1(2), FGF10(2), FGF11(1), FGF12(1), FGF13(1), FGF14(1), FGF19(2), FGF20(1), FGF21(1), FGF3(4), FGF6(4), FGF7(2), FGFR1(6), FGFR2(4), FGFR3(7), FGFR4(3), FN1(8), GIT1(3), GNA12(1), GNA13(4), GNG12(1), GSN(5), HRAS(1), INS(1), IQGAP1(5), IQGAP2(7), IQGAP3(6), ITGA1(8), ITGA10(4), ITGA11(6), ITGA2(4), ITGA2B(1), ITGA3(6), ITGA4(3), ITGA5(5), ITGA6(6), ITGA7(6), ITGA8(3), ITGA9(3), ITGAD(12), ITGAE(6), ITGAL(7), ITGAM(9), ITGAV(1), ITGAX(8), ITGB1(7), ITGB2(2), ITGB3(3), ITGB4(7), ITGB5(6), ITGB6(2), ITGB7(4), ITGB8(1), KRAS(3), LIMK2(4), MAP2K2(1), MAPK3(3), MOS(1), MRAS(1), MSN(3), MYH10(3), MYH14(8), MYH9(3), MYL2(1), MYL7(2), MYL9(1), MYLK(4), MYLK2(1), NCKAP1(2), NCKAP1L(5), NRAS(2), PAK1(3), PAK2(4), PAK3(1), PAK4(3), PAK6(5), PAK7(3), PDGFRA(6), PDGFRB(3), PFN3(1), PFN4(1), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PIP4K2A(4), PIP4K2B(2), PIP4K2C(3), PIP5K1A(2), PIP5K1B(1), PIP5K1C(4), PPP1CA(1), PPP1CC(2), PPP1R12A(3), PPP1R12B(2), PTK2(3), PXN(3), RAC2(1), RAC3(1), RAF1(4), RDX(2), ROCK1(5), ROCK2(3), SCIN(3), SLC9A1(3), SOS1(8), SOS2(7), SSH1(2), SSH2(12), SSH3(2), TIAM1(9), TIAM2(1), VAV1(4), VAV2(4), VAV3(1), VCL(2), WAS(1), WASF1(1), WASF2(2) 272707918 558 337 542 141 57 68 78 208 143 4 0.0986 1.000 1.000 418 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 134 ACTG1(4), CHAD(3), COL11A1(9), COL11A2(5), COL17A1(5), COL1A1(6), COL1A2(10), COL2A1(6), COL3A1(3), COL4A1(3), COL4A2(2), COL4A4(4), COL4A6(7), COL5A1(8), COL5A2(6), COL5A3(12), COL6A1(3), COL6A2(7), COL6A3(20), COL6A6(17), DES(1), DSC2(4), DSC3(3), DSG1(4), DSG2(3), DSG3(3), DSG4(5), FN1(8), GJA10(3), GJA3(2), GJA5(5), GJA8(1), GJA9(1), GJB1(2), GJB3(2), GJB5(1), GJB6(2), GJC1(3), GJC2(1), GJD2(1), IBSP(1), ITGA6(6), ITGB4(7), KRT1(3), KRT10(2), KRT12(2), KRT13(6), KRT15(2), KRT16(1), KRT17(4), KRT18(1), KRT19(2), KRT2(5), KRT20(1), KRT23(3), KRT24(1), KRT25(1), KRT27(4), KRT28(2), KRT3(2), KRT31(1), KRT32(1), KRT33A(1), KRT33B(2), KRT34(1), KRT35(2), KRT36(2), KRT37(1), KRT38(2), KRT39(1), KRT4(6), KRT40(2), KRT5(3), KRT6A(3), KRT6B(3), KRT6C(1), KRT7(1), KRT71(2), KRT72(2), KRT73(2), KRT74(2), KRT75(4), KRT76(4), KRT77(4), KRT78(3), KRT79(4), KRT81(1), KRT82(2), KRT83(2), KRT84(4), KRT85(6), KRT86(2), KRT9(2), LAMA1(11), LAMA2(9), LAMA3(10), LAMA4(9), LAMA5(9), LAMB1(16), LAMB2(7), LAMB3(4), LAMB4(5), LAMC1(5), LAMC2(6), LAMC3(8), LMNB1(3), LMNB2(1), NES(6), PRPH(3), RELN(7), SPP1(3), THBS2(3), THBS3(5), THBS4(2), TNC(13), TNN(2), TNR(9), TNXB(11), VIM(2), VTN(1), VWF(15) 240606104 515 315 506 174 62 70 52 179 150 2 0.884 1.000 1.000 419 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 234 ADCYAP1R1(2), ADORA2A(5), ADORA2B(1), ADORA3(2), ADRA1A(4), ADRA2B(1), ADRB2(2), AGTR1(2), AGTR2(1), AVPR1A(1), AVPR2(3), BDKRB1(1), BDKRB2(1), BRS3(2), C3AR1(3), C5AR1(3), CALCR(3), CALCRL(2), CCKAR(4), CCKBR(3), CGA(1), CHRM1(2), CHRM2(6), CHRM3(3), CHRM5(2), CNR1(1), CNR2(3), CRHR1(2), CRHR2(3), CYSLTR1(1), DRD1(1), DRD2(1), DRD3(3), DRD5(4), EDNRB(3), F2(3), F2R(2), F2RL1(1), F2RL2(2), F2RL3(1), FPR1(2), FSHR(2), GABBR1(5), GABRA1(3), GABRA2(1), GABRA3(1), GABRA4(1), GABRA5(1), GABRA6(1), GABRB1(2), GABRB2(3), GABRB3(2), GABRD(2), GABRE(4), GABRG1(3), GABRG2(5), GABRG3(3), GABRQ(8), GABRR1(2), GALR1(1), GH2(1), GHR(1), GIPR(2), GLP1R(3), GLP2R(3), GLRA1(3), GLRA2(2), GLRB(1), GPR156(1), GPR35(3), GPR50(3), GPR63(1), GPR83(2), GRIA1(8), GRIA2(4), GRIA3(2), GRIA4(4), GRID1(4), GRID2(9), GRIK1(3), GRIK2(4), GRIK3(6), GRIK5(5), GRIN1(2), GRIN2A(8), GRIN2B(8), GRIN2D(2), GRIN3A(2), GRIN3B(5), GRM1(4), GRM2(5), GRM3(5), GRM4(6), GRM5(8), GRM6(2), GRM7(5), GRM8(3), GRPR(2), HCRTR1(2), HCRTR2(4), HRH2(1), HRH3(2), HRH4(1), HTR1A(2), HTR1B(1), HTR1D(2), HTR1E(3), HTR1F(2), HTR2A(1), HTR2B(1), HTR2C(1), HTR4(2), HTR6(2), HTR7(2), LEP(1), LEPR(5), LTB4R2(1), MAS1(1), MC1R(2), MC2R(2), MC3R(2), MC4R(1), MC5R(1), MCHR1(1), MCHR2(2), MLNR(1), MTNR1B(1), NMUR2(6), NPBWR1(2), NPBWR2(1), NPFFR2(3), NPY1R(1), NPY2R(2), NR3C1(4), NTSR1(3), OPRD1(3), OPRK1(2), OPRL1(1), OPRM1(3), OXTR(1), P2RX1(3), P2RX2(4), P2RX3(3), P2RX5(1), P2RX7(2), P2RY1(3), P2RY10(1), P2RY11(1), P2RY13(1), P2RY14(1), P2RY2(2), P2RY4(1), P2RY6(2), P2RY8(2), PARD3(6), PRLR(3), PRSS1(6), PRSS3(9), PTAFR(1), PTGDR(1), PTGER2(1), PTGER4(1), PTGFR(5), PTGIR(2), RXFP1(1), RXFP2(3), SCTR(1), SSTR1(3), SSTR2(2), SSTR3(2), SSTR4(3), TAAR2(2), TACR1(1), TACR2(1), TACR3(2), TBXA2R(4), THRA(1), TRHR(2), TRPV1(2), TSHR(2), TSPO(1), UTS2R(2), VIPR1(1), VIPR2(2) 214927195 467 298 455 148 73 62 70 172 90 0 0.360 1.000 1.000 420 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 84 AGRN(10), CD36(1), CD44(3), CHAD(3), COL11A1(9), COL11A2(5), COL1A1(6), COL1A2(10), COL2A1(6), COL3A1(3), COL4A1(3), COL4A2(2), COL4A4(4), COL4A6(7), COL5A1(8), COL5A2(6), COL5A3(12), COL6A1(3), COL6A2(7), COL6A3(20), COL6A6(17), DAG1(3), FN1(8), FNDC1(3), FNDC3A(3), FNDC5(1), GP9(1), HMMR(1), HSPG2(13), IBSP(1), ITGA1(8), ITGA10(4), ITGA11(6), ITGA2(4), ITGA2B(1), ITGA3(6), ITGA4(3), ITGA5(5), ITGA6(6), ITGA7(6), ITGA8(3), ITGA9(3), ITGAV(1), ITGB1(7), ITGB3(3), ITGB4(7), ITGB5(6), ITGB6(2), ITGB7(4), ITGB8(1), LAMA1(11), LAMA2(9), LAMA3(10), LAMA4(9), LAMA5(9), LAMB1(16), LAMB2(7), LAMB3(4), LAMB4(5), LAMC1(5), LAMC2(6), LAMC3(8), RELN(7), SDC1(1), SDC2(1), SDC3(1), SDC4(1), SPP1(3), SV2A(1), SV2B(3), SV2C(2), THBS2(3), THBS3(5), THBS4(2), TNC(13), TNN(2), TNR(9), TNXB(11), VTN(1), VWF(15) 218343637 445 292 435 131 48 58 51 149 136 3 0.481 1.000 1.000 421 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(2), ADCY2(7), ADCY3(6), ADCY4(3), ADCY5(7), ADCY6(2), ADCY7(1), ADCY8(12), ADCY9(7), ADRA1A(4), ADRB2(2), ANXA6(3), ARRB1(3), ARRB2(1), ATP1A4(4), ATP1B1(5), ATP2A2(7), ATP2A3(5), ATP2B1(4), ATP2B3(2), CACNA1A(14), CACNA1B(5), CACNA1C(17), CACNA1D(9), CACNA1E(3), CACNA1S(14), CACNB1(4), CALM2(1), CALR(2), CAMK1(3), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(3), CASQ1(4), CASQ2(2), CHRM1(2), CHRM2(6), CHRM3(3), CHRM5(2), GJA5(5), GJB1(2), GJB3(2), GJB5(1), GJB6(2), GNA11(1), GNAI2(2), GNAI3(1), GNAO1(1), GNAZ(3), GNB1(3), GNB3(2), GNB5(2), GNG12(1), GNG3(1), GNG7(1), GRK4(2), GRK5(2), GRK6(5), ITPR1(7), ITPR2(12), ITPR3(5), KCNB1(2), KCNJ3(4), MIB1(1), MYCBP(1), NME7(2), PKIA(1), PLCB3(3), PRKACA(2), PRKACB(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PRKCA(2), PRKCD(5), PRKCE(4), PRKCG(6), PRKCH(4), PRKCQ(5), PRKCZ(1), PRKD1(4), RGS1(1), RGS11(1), RGS14(1), RGS16(2), RGS17(2), RGS18(2), RGS2(2), RGS20(1), RGS3(5), RGS6(3), RGS7(1), RGS9(5), RYR1(23), RYR2(17), RYR3(18), SFN(1), SLC8A1(3), SLC8A3(4), USP5(4), YWHAB(1) 189765843 401 272 390 123 73 49 37 135 107 0 0.380 1.000 1.000 422 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 124 ABL1(8), ABLIM1(5), ABLIM2(2), ABLIM3(3), ARHGEF12(5), CDC42(1), CFL1(1), CFL2(1), CXCR4(1), DCC(7), DPYSL2(3), EFNA1(2), EFNA3(1), EFNB1(1), EFNB2(1), EPHA1(4), EPHA2(1), EPHA3(5), EPHA4(2), EPHA5(5), EPHA6(4), EPHA7(2), EPHA8(5), EPHB1(4), EPHB2(2), EPHB4(6), EPHB6(7), FES(4), FYN(2), GNAI1(2), GNAI2(2), GNAI3(1), GSK3B(3), HRAS(1), ITGB1(7), KRAS(3), L1CAM(5), LIMK2(4), LRRC4C(2), MAPK3(3), NCK1(1), NCK2(2), NFAT5(8), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), NGEF(1), NRAS(2), NRP1(2), NTN4(2), NTNG1(3), PAK1(3), PAK2(4), PAK3(1), PAK4(3), PAK6(5), PAK7(3), PLXNA1(4), PLXNA2(10), PLXNA3(5), PLXNB1(9), PLXNB2(6), PLXNB3(4), PLXNC1(4), PPP3CA(3), PPP3CC(3), PTK2(3), RAC2(1), RAC3(1), RASA1(7), RGS3(5), RND1(2), ROBO1(5), ROBO2(9), ROBO3(4), ROCK1(5), ROCK2(3), SEMA3A(4), SEMA3C(2), SEMA3D(3), SEMA3E(3), SEMA3F(2), SEMA3G(1), SEMA4A(1), SEMA4B(1), SEMA4C(1), SEMA4D(2), SEMA4F(7), SEMA4G(5), SEMA5A(7), SEMA5B(2), SEMA6A(3), SEMA6B(2), SEMA6C(4), SEMA6D(3), SEMA7A(1), SLIT1(3), SLIT2(9), SLIT3(7), SRGAP1(10), SRGAP2(1), SRGAP3(4), UNC5A(4), UNC5B(5), UNC5C(3), UNC5D(2) 188813216 385 255 366 104 41 44 45 140 113 2 0.363 1.000 1.000 423 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 127 ACTG1(4), ACTN1(1), ACTN2(3), ACTN4(3), AKT1(2), AKT2(5), AKT3(3), AMOTL1(4), ASH1L(7), CASK(2), CDC42(1), CDK4(6), CGN(4), CLDN10(2), CLDN11(1), CLDN15(1), CLDN16(2), CLDN18(2), CLDN2(1), CLDN23(1), CLDN4(2), CLDN6(1), CLDN7(1), CSNK2A1(3), CSNK2A2(2), CSNK2B(1), CTNNA1(7), CTNNA2(7), CTNNA3(3), CTNNB1(2), EPB41(2), EPB41L1(4), EPB41L2(1), EPB41L3(7), EXOC4(3), F11R(1), GNAI1(2), GNAI2(2), GNAI3(1), HCLS1(1), HRAS(1), IGSF5(5), INADL(10), JAM3(2), KRAS(3), LLGL1(5), LLGL2(2), MAGI1(4), MAGI2(6), MAGI3(4), MLLT4(11), MPDZ(4), MPP5(1), MRAS(1), MYH1(5), MYH10(3), MYH11(10), MYH13(6), MYH14(8), MYH15(5), MYH2(9), MYH3(6), MYH4(15), MYH6(7), MYH7(13), MYH7B(6), MYH8(6), MYH9(3), MYL2(1), MYL7(2), MYL9(1), NRAS(2), OCLN(3), PARD3(6), PPM1J(3), PPP2CA(1), PPP2CB(2), PPP2R1A(2), PPP2R1B(2), PPP2R2A(6), PPP2R2B(3), PPP2R2C(3), PPP2R3A(1), PPP2R3B(1), PPP2R4(1), PRKCA(2), PRKCD(5), PRKCE(4), PRKCG(6), PRKCH(4), PRKCI(5), PRKCQ(5), PRKCZ(1), RAB13(1), RAB3B(1), SPTAN1(12), SRC(3), SYMPK(1), TJAP1(4), TJP1(6), TJP2(4), TJP3(1), YES1(2), ZAK(4) 191203220 380 253 364 122 37 46 41 122 132 2 0.927 1.000 1.000 424 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 129 ALCAM(3), CADM1(3), CADM3(3), CD2(2), CD22(4), CD276(2), CD28(1), CD34(2), CD40(1), CD58(1), CD6(3), CD80(1), CD86(3), CD8A(1), CD99(1), CDH1(2), CDH15(1), CDH2(7), CDH3(3), CDH4(5), CDH5(4), CLDN10(2), CLDN11(1), CLDN15(1), CLDN16(2), CLDN18(2), CLDN2(1), CLDN23(1), CLDN4(2), CLDN6(1), CLDN7(1), CNTN1(7), CNTN2(3), CNTNAP1(9), CNTNAP2(5), CTLA4(3), ESAM(3), F11R(1), GLG1(5), HLA-A(6), HLA-B(10), HLA-C(11), HLA-DOA(1), HLA-DPA1(1), HLA-DPB1(3), HLA-DQA1(3), HLA-DQA2(3), HLA-DQB1(3), HLA-DRA(1), HLA-DRB1(6), HLA-DRB5(8), HLA-E(2), HLA-F(1), ICAM1(3), ICOS(3), ICOSLG(1), ITGA4(3), ITGA6(6), ITGA8(3), ITGA9(3), ITGAL(7), ITGAM(9), ITGAV(1), ITGB1(7), ITGB2(2), ITGB7(4), ITGB8(1), JAM3(2), L1CAM(5), MADCAM1(3), MAG(1), MPZL1(2), NCAM1(2), NCAM2(5), NEGR1(2), NEO1(5), NFASC(8), NRCAM(4), NRXN1(10), NRXN2(5), NRXN3(4), OCLN(3), PDCD1(1), PTPRC(8), PTPRF(8), PTPRM(9), PVRL1(1), PVRL2(6), PVRL3(4), SDC1(1), SDC2(1), SDC3(1), SDC4(1), SELE(5), SELL(2), SELP(2), SELPLG(3), SIGLEC1(4), SPN(1), VCAM1(6), VCAN(15) 143069901 355 247 349 115 34 43 48 144 86 0 0.741 1.000 1.000 425 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 247 ACVR1(1), ACVR1B(3), ACVR2A(4), ACVR2B(1), BMP2(1), BMP7(5), BMPR1A(1), BMPR1B(2), BMPR2(5), CCL2(1), CCL27(2), CCL3(1), CCR2(2), CCR3(2), CCR5(1), CCR6(1), CCR7(1), CCR9(1), CD27(3), CD40(1), CLCF1(1), CNTF(1), CSF1R(6), CSF2RA(3), CSF2RB(5), CSF3R(3), CX3CL1(2), CX3CR1(1), CXCL1(1), CXCL11(1), CXCL13(1), CXCL5(1), CXCL9(1), CXCR4(1), CXCR6(1), EDA(2), EDA2R(1), EGF(5), EGFR(9), EPOR(3), FAS(2), FASLG(2), FLT1(8), FLT3(6), FLT4(14), GDF5(5), GH2(1), GHR(1), HGF(1), IFNA1(1), IFNA14(1), IFNA16(2), IFNA2(1), IFNA21(3), IFNA5(1), IFNA7(3), IFNA8(2), IFNAR1(3), IFNB1(2), IFNGR1(3), IFNGR2(2), IFNK(1), IL10RA(4), IL11RA(2), IL12RB1(4), IL12RB2(2), IL13RA1(2), IL15(1), IL15RA(2), IL17RA(1), IL17RB(4), IL18R1(1), IL18RAP(4), IL19(2), IL1B(1), IL1R1(3), IL1R2(8), IL1RAP(4), IL20RA(1), IL21(1), IL21R(5), IL22RA1(3), IL22RA2(1), IL23A(1), IL23R(4), IL25(2), IL26(1), IL2RA(2), IL2RB(2), IL3(1), IL4(1), IL4R(4), IL5RA(2), IL6R(2), IL6ST(6), IL7R(1), IL9(1), IL9R(6), INHBA(2), INHBB(2), INHBC(1), INHBE(1), KDR(6), KITLG(2), LEP(1), LEPR(5), LIFR(5), LTA(1), LTB(1), LTBR(2), NGFR(1), OSM(2), OSMR(1), PDGFC(1), PDGFRA(6), PDGFRB(3), PF4(1), PLEKHO2(1), PRLR(3), RELT(1), TGFB2(2), TGFBR1(1), TGFBR2(2), TNF(1), TNFRSF10B(1), TNFRSF10C(2), TNFRSF11B(1), TNFRSF13B(1), TNFRSF19(2), TNFRSF1A(1), TNFRSF1B(1), TNFRSF21(4), TNFRSF25(1), TNFRSF4(1), TNFRSF9(1), TNFSF13(1), TNFSF14(1), TNFSF15(2), TNFSF8(1), TNFSF9(1), TPO(4), VEGFA(1), VEGFC(2), XCL1(2), XCR1(1) 171207094 332 246 325 63 35 46 42 126 83 0 0.000793 1.000 1.000 426 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA1(1), ACTA2(1), ADCY1(2), ADCY2(7), ADCY3(6), ADCY4(3), ADCY5(7), ADCY6(2), ADCY7(1), ADCY8(12), ADCY9(7), ARRB1(3), ARRB2(1), ATF1(2), ATF2(2), ATF3(1), ATF4(2), ATF5(1), ATP2A2(7), ATP2A3(5), CALCA(1), CALM2(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CNN2(3), CORIN(2), CRHR1(2), DGKZ(5), ETS2(1), FOS(1), GABPA(2), GABPB2(1), GBA2(4), GNB1(3), GNB3(2), GNB5(2), GNG12(1), GNG3(1), GNG7(1), GRK4(2), GRK5(2), GRK6(5), GSTO1(1), GUCA2A(1), GUCA2B(1), GUCY1A3(3), IGFBP1(1), IGFBP2(2), IGFBP3(1), IGFBP4(2), IGFBP6(3), IL1B(1), ITPR1(7), ITPR2(12), ITPR3(5), JUN(2), MIB1(1), MYL2(1), MYLK2(1), NFKB1(2), NOS1(10), NOS3(3), OXTR(1), PDE4B(1), PDE4D(1), PKIA(1), PLCB3(3), PLCD1(3), PLCG1(4), PLCG2(4), PRKACA(2), PRKACB(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PRKCA(2), PRKCD(5), PRKCE(4), PRKCH(4), PRKCQ(5), PRKCZ(1), PRKD1(4), RAMP1(1), RAMP2(1), RAMP3(1), RGS1(1), RGS11(1), RGS14(1), RGS16(2), RGS17(2), RGS18(2), RGS2(2), RGS20(1), RGS3(5), RGS6(3), RGS7(1), RGS9(5), RLN1(1), RYR1(23), RYR2(17), RYR3(18), SFN(1), SLC8A1(3), SP1(2), TNXB(11), USP5(4), YWHAB(1) 172236472 343 245 336 93 54 48 32 117 92 0 0.216 1.000 1.000 427 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 126 ACACA(9), ACACB(5), AKT1(2), AKT2(5), AKT3(3), ARAF(1), BAD(1), BRAF(4), CALM2(1), CBL(3), CBLB(4), CBLC(2), CRKL(1), EIF4EBP1(1), ELK1(1), EXOC7(6), FASN(9), FLOT2(1), FOXO1(4), G6PC(3), GCK(2), GRB2(2), GSK3B(3), GYS1(3), GYS2(3), HRAS(1), IKBKB(3), INPP5D(2), INS(1), IRS1(5), IRS4(1), KRAS(3), LIPE(6), MAP2K2(1), MAPK10(2), MAPK3(3), MAPK9(2), MKNK1(2), MKNK2(1), NRAS(2), PCK1(5), PCK2(2), PDE3A(3), PDE3B(3), PFKL(3), PFKM(3), PFKP(3), PHKA1(10), PHKA2(5), PHKB(4), PHKG1(3), PHKG2(1), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PKLR(1), PPARGC1A(4), PPP1CA(1), PPP1CC(2), PPP1R3A(4), PPP1R3B(1), PPP1R3C(1), PPP1R3D(1), PRKAA1(1), PRKAB1(1), PRKACA(2), PRKACB(2), PRKACG(2), PRKAG1(5), PRKAG2(6), PRKAG3(1), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PRKCI(5), PRKCZ(1), PRKX(2), PTPN1(2), PTPRF(8), PYGB(3), PYGL(2), PYGM(4), RAF1(4), RAPGEF1(5), RHOQ(1), RPS6KB1(2), RPS6KB2(2), SH2B2(2), SHC1(4), SHC2(4), SHC3(1), SHC4(1), SLC2A4(2), SOCS3(1), SOCS4(1), SORBS1(3), SOS1(8), SOS2(7), SREBF1(4), TRIP10(2), TSC1(5), TSC2(12) 151448136 321 241 314 71 34 51 43 116 73 4 0.00636 1.000 1.000 428 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 143 APC(9), APC2(5), AXIN1(4), AXIN2(1), BTRC(2), CACYBP(4), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CCND2(1), CHD8(6), CREBBP(9), CSNK1A1(2), CSNK1E(3), CSNK2A1(3), CSNK2A2(2), CSNK2B(1), CTBP1(2), CTBP2(1), CTNNB1(2), CUL1(5), CXXC4(2), DAAM1(5), DAAM2(1), DVL1(1), DVL2(1), EP300(16), FBXW11(2), FZD1(3), FZD10(4), FZD2(2), FZD3(1), FZD4(4), FZD5(2), FZD7(1), GSK3B(3), JUN(2), LEF1(3), LRP5(6), LRP6(8), MAP3K7(3), MAPK10(2), MAPK9(2), MYC(1), NFAT5(8), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), NKD1(4), NKD2(4), NLK(1), PLCB1(3), PLCB2(4), PLCB3(3), PLCB4(5), PORCN(2), PPARD(1), PPP2CA(1), PPP2CB(2), PPP2R1A(2), PPP2R1B(2), PPP2R2A(6), PPP2R2B(3), PPP2R2C(3), PPP3CA(3), PPP3CC(3), PRICKLE1(4), PRICKLE2(2), PRKACA(2), PRKACB(2), PRKACG(2), PRKCA(2), PRKCG(6), PRKX(2), RAC2(1), RAC3(1), RBX1(1), ROCK1(5), ROCK2(3), SENP2(1), SFRP2(1), SFRP4(2), SFRP5(3), SMAD2(2), SMAD3(2), SMAD4(3), TBL1X(3), TBL1XR1(5), TCF7L1(2), TCF7L2(1), VANGL1(5), VANGL2(3), WIF1(5), WNT1(2), WNT10A(3), WNT10B(1), WNT11(1), WNT2(2), WNT2B(2), WNT3(3), WNT3A(1), WNT5B(2), WNT7B(1), WNT8A(3), WNT8B(1), WNT9B(1) 157230717 318 231 306 80 32 33 46 108 98 1 0.182 1.000 1.000 429 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 149 AKT1(2), AKT2(5), AKT3(3), CBL(3), CBLB(4), CBLC(2), CCND2(1), CISH(2), CLCF1(1), CNTF(1), CREBBP(9), CSF2RA(3), CSF2RB(5), CSF3R(3), EP300(16), EPOR(3), GH2(1), GHR(1), GRB2(2), IFNA1(1), IFNA14(1), IFNA16(2), IFNA2(1), IFNA21(3), IFNA5(1), IFNA7(3), IFNA8(2), IFNAR1(3), IFNB1(2), IFNGR1(3), IFNGR2(2), IFNK(1), IL10RA(4), IL11RA(2), IL12RB1(4), IL12RB2(2), IL13RA1(2), IL15(1), IL15RA(2), IL19(2), IL20RA(1), IL21(1), IL21R(5), IL22RA1(3), IL22RA2(1), IL23A(1), IL23R(4), IL26(1), IL2RA(2), IL2RB(2), IL3(1), IL4(1), IL4R(4), IL5RA(2), IL6R(2), IL6ST(6), IL7R(1), IL9(1), IL9R(6), IRF9(2), JAK1(6), JAK2(7), JAK3(4), LEP(1), LEPR(5), LIFR(5), MYC(1), OSM(2), OSMR(1), PIAS1(5), PIAS2(3), PIAS3(3), PIAS4(1), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PRLR(3), PTPN11(2), PTPN6(3), SOCS3(1), SOCS4(1), SOCS5(2), SOCS7(2), SOS1(8), SOS2(7), SPRED1(6), SPRED2(2), SPRY1(1), SPRY2(3), STAM(6), STAT1(5), STAT2(7), STAT3(3), STAT4(2), STAT5A(3), STAT5B(3), STAT6(5), TPO(4), TYK2(7) 141745004 311 221 302 72 26 39 54 108 84 0 0.0626 1.000 1.000 430 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(2), AKT3(3), BCAR1(6), CAPN1(2), CAPN10(2), CAPN11(5), CAPN2(4), CAPN3(8), CAPN5(2), CAPN6(2), CAPN7(4), CAPN9(3), CAV2(2), CAV3(1), CDC42(1), CSK(4), DOCK1(3), FYN(2), GIT2(4), GRB2(2), ILK(4), ITGA10(4), ITGA11(6), ITGA2(4), ITGA2B(1), ITGA3(6), ITGA4(3), ITGA5(5), ITGA6(6), ITGA7(6), ITGA8(3), ITGA9(3), ITGAD(12), ITGAE(6), ITGAL(7), ITGAM(9), ITGAV(1), ITGAX(8), ITGB1(7), ITGB2(2), ITGB3(3), ITGB4(7), ITGB5(6), ITGB6(2), ITGB7(4), ITGB8(1), MAP2K2(1), MAP2K3(3), MAPK10(2), MAPK12(1), MAPK4(2), MAPK6(1), MAPK7(4), MYLK2(1), PAK1(3), PAK2(4), PAK3(1), PAK4(3), PAK6(5), PIK3R2(3), PTK2(3), PXN(3), RAC2(1), RAC3(1), RAPGEF1(5), RHO(1), ROCK1(5), ROCK2(3), SDCCAG8(1), SEPP1(2), SHC1(4), SHC3(1), SORBS1(3), SOS1(8), SRC(3), TLN1(13), TNS1(9), VAV2(4), VAV3(1), VCL(2), ZYX(1) 134851201 296 220 285 86 22 44 40 106 82 2 0.457 1.000 1.000 431 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 141 ADA(2), ADCY1(2), ADCY2(7), ADCY3(6), ADCY4(3), ADCY5(7), ADCY6(2), ADCY7(1), ADCY8(12), ADCY9(7), ADK(1), ADSL(3), ADSSL1(2), AK2(3), AK5(2), AK7(3), ALLC(3), AMPD1(2), AMPD2(5), AMPD3(4), ATIC(2), CANT1(1), DCK(1), ENPP1(4), ENPP3(2), ENTPD1(1), ENTPD2(1), ENTPD5(3), ENTPD6(2), GART(4), GDA(3), GMPR(2), GMPS(1), GUCY1A2(1), GUCY1A3(3), GUCY1B3(3), GUCY2C(5), GUCY2D(4), GUCY2F(6), HPRT1(1), IMPDH1(1), NME7(2), NPR1(4), NPR2(5), NT5C1A(2), NT5C1B(2), NT5C2(1), NT5M(2), NUDT5(4), NUDT9(1), PAPSS1(2), PAPSS2(4), PDE10A(1), PDE11A(7), PDE1A(1), PDE1C(2), PDE2A(3), PDE3B(3), PDE4A(2), PDE4B(1), PDE4C(7), PDE4D(1), PDE5A(5), PDE7A(1), PDE7B(1), PDE8A(2), PDE8B(2), PFAS(3), PKLR(1), PNPT1(2), POLA1(4), POLD1(7), POLD3(1), POLE(5), POLE2(1), POLR1A(6), POLR1B(4), POLR1C(2), POLR1D(1), POLR2A(13), POLR2B(7), POLR2F(4), POLR2I(1), POLR2J(1), POLR3A(5), POLR3B(5), POLR3G(1), POLR3H(1), POLR3K(1), PPAT(3), PRIM1(3), PRIM2(4), PRPS1(1), PRPS1L1(2), PRPS2(4), PRUNE(3), RFC5(3), RRM1(2), RRM2(1), XDH(6) 162727812 304 217 297 69 30 44 34 116 80 0 0.0506 1.000 1.000 432 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 92 ADCY1(2), ADCY2(7), ADCY3(6), ADCY4(3), ADCY5(7), ADCY6(2), ADCY7(1), ADCY8(12), ADCY9(7), DRD1(1), DRD2(1), EGF(5), EGFR(9), GJD2(1), GNA11(1), GNAI1(2), GNAI2(2), GNAI3(1), GNAS(6), GRB2(2), GRM1(4), GRM5(8), GUCY1A2(1), GUCY1A3(3), GUCY1B3(3), GUCY2C(5), GUCY2D(4), GUCY2F(6), HRAS(1), HTR2A(1), HTR2B(1), HTR2C(1), ITPR1(7), ITPR2(12), ITPR3(5), KRAS(3), MAP2K2(1), MAP2K5(3), MAP3K2(2), MAPK3(3), MAPK7(4), NPR1(4), NPR2(5), NRAS(2), PDGFC(1), PDGFD(4), PDGFRA(6), PDGFRB(3), PLCB1(3), PLCB2(4), PLCB3(3), PLCB4(5), PRKACA(2), PRKACB(2), PRKACG(2), PRKCA(2), PRKCG(6), PRKG1(4), PRKG2(3), PRKX(2), RAF1(4), SOS1(8), SOS2(7), SRC(3), TJP1(6), TUBA1A(2), TUBA3C(1), TUBA3D(2), TUBA4A(6), TUBAL3(3), TUBB(3), TUBB1(3), TUBB2B(2), TUBB8(4) 131344298 273 200 267 85 34 44 27 105 63 0 0.674 1.000 1.000 433 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY1(2), ADCY2(7), ADCY3(6), ADCY4(3), ADCY5(7), ADCY6(2), ADCY7(1), ADCY8(12), ADCY9(7), ATF4(2), CACNA1C(17), CACNA1D(9), CACNA1F(4), CACNA1S(14), CALM2(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CDC42(1), CGA(1), EGFR(9), ELK1(1), GNA11(1), GNAS(6), GRB2(2), HRAS(1), ITPR1(7), ITPR2(12), ITPR3(5), JUN(2), KRAS(3), MAP2K2(1), MAP2K3(3), MAP2K7(1), MAP3K1(7), MAP3K2(2), MAP3K3(2), MAP3K4(7), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(3), MAPK7(4), MAPK9(2), MMP14(1), MMP2(6), NRAS(2), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(4), PLCB1(3), PLCB2(4), PLCB3(3), PLCB4(5), PLD1(2), PLD2(5), PRKACA(2), PRKACB(2), PRKACG(2), PRKCA(2), PRKCD(5), PRKX(2), PTK2B(3), RAF1(4), SOS1(8), SOS2(7), SRC(3) 128842288 268 197 260 88 37 45 29 98 59 0 0.621 1.000 1.000 434 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 109 ADA(2), ADCY1(2), ADCY2(7), ADCY3(6), ADCY4(3), ADCY5(7), ADCY6(2), ADCY7(1), ADCY8(12), ADK(1), ADSL(3), AK2(3), AK5(2), ALLC(3), AMPD1(2), AMPD2(5), AMPD3(4), ATIC(2), ATP1B1(5), ATP5A1(3), ATP5B(3), ATP5C1(1), ATP5F1(1), ATP5G2(1), CANT1(1), DCK(1), ENPP1(4), ENPP3(2), ENTPD1(1), ENTPD2(1), GART(4), GDA(3), GMPS(1), GUCY1A2(1), GUCY1A3(3), GUCY1B3(3), GUCY2C(5), GUCY2D(4), GUCY2F(6), HPRT1(1), IMPDH1(1), NPR1(4), NPR2(5), NT5M(2), PAPSS1(2), PAPSS2(4), PDE1A(1), PDE4A(2), PDE4B(1), PDE4C(7), PDE4D(1), PDE5A(5), PDE6B(6), PDE6C(3), PDE7B(1), PDE8A(2), PFAS(3), PKLR(1), POLB(2), POLD1(7), POLE(5), POLG(6), POLL(2), POLQ(14), POLR1B(4), POLR2A(13), POLR2B(7), POLR2F(4), POLR2I(1), POLR2J(1), POLRMT(5), PPAT(3), PRPS1(1), PRPS1L1(2), PRPS2(4), PRUNE(3), RRM1(2), RRM2(1) 126537800 260 197 255 52 30 34 30 94 72 0 0.0134 1.000 1.000 435 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 124 ARAF(1), BID(2), BRAF(4), CD48(1), FAS(2), FASLG(2), FCER1G(1), FYN(2), GRB2(2), HCST(1), HLA-A(6), HLA-B(10), HLA-C(11), HLA-E(2), HRAS(1), ICAM1(3), IFNA1(1), IFNA14(1), IFNA16(2), IFNA2(1), IFNA21(3), IFNA5(1), IFNA7(3), IFNA8(2), IFNAR1(3), IFNB1(2), IFNGR1(3), IFNGR2(2), ITGAL(7), ITGB2(2), KIR2DL3(1), KIR3DL1(3), KIR3DL2(1), KLRC1(3), KLRC2(3), KLRC3(2), KLRK1(3), KRAS(3), LCK(1), LCP2(3), MAP2K2(1), MAPK3(3), MICA(1), MICB(4), NCR1(1), NCR2(1), NFAT5(8), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), NRAS(2), PAK1(3), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PLCG1(4), PLCG2(4), PPP3CA(3), PPP3CC(3), PRF1(1), PRKCA(2), PRKCG(6), PTK2B(3), PTPN11(2), PTPN6(3), RAC2(1), RAC3(1), RAF1(4), SH2D1B(1), SH3BP2(6), SHC1(4), SHC2(4), SHC3(1), SHC4(1), SOS1(8), SOS2(7), SYK(2), TNF(1), TNFRSF10B(1), TNFRSF10C(2), ULBP1(2), ULBP2(1), VAV1(4), VAV2(4), VAV3(1), ZAP70(1) 108727093 264 192 258 62 23 40 33 100 66 2 0.123 1.000 1.000 436 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 ARAF(1), BRAF(4), CACNA1A(14), CRHR1(2), GNA11(1), GNA12(1), GNA13(4), GNAI1(2), GNAI2(2), GNAI3(1), GNAO1(1), GNAS(6), GNAZ(3), GRIA1(8), GRIA2(4), GRIA3(2), GRID2(9), GRM1(4), GRM5(8), GUCY1A2(1), GUCY1A3(3), GUCY1B3(3), GUCY2C(5), GUCY2D(4), GUCY2F(6), HRAS(1), IGF1R(3), ITPR1(7), ITPR2(12), ITPR3(5), KRAS(3), LYN(1), MAP2K2(1), MAPK3(3), NOS1(10), NOS3(3), NPR1(4), NPR2(5), NRAS(2), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(4), PLCB1(3), PLCB2(4), PLCB3(3), PLCB4(5), PPP2CA(1), PPP2CB(2), PPP2R1A(2), PPP2R1B(2), PPP2R2A(6), PPP2R2B(3), PPP2R2C(3), PRKCA(2), PRKCG(6), PRKG1(4), PRKG2(3), RAF1(4), RYR1(23) 110431542 244 187 241 67 42 26 24 91 60 1 0.296 1.000 1.000 437 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 71 ACP1(1), ACTG1(4), ACTN1(1), ACTN2(3), ACTN4(3), ACVR1B(3), ACVR1C(3), BAIAP2(2), CDC42(1), CDH1(2), CREBBP(9), CSNK2A1(3), CSNK2A2(2), CSNK2B(1), CTNNA1(7), CTNNA2(7), CTNNA3(3), CTNNB1(2), CTNND1(5), EGFR(9), EP300(16), ERBB2(8), FARP2(3), FER(2), FGFR1(6), FYN(2), IGF1R(3), IQGAP1(5), LEF1(3), LMO7(11), MAP3K7(3), MAPK3(3), MLLT4(11), NLK(1), PARD3(6), PTPN1(2), PTPN6(3), PTPRB(5), PTPRF(8), PTPRJ(12), PTPRM(9), PVRL1(1), PVRL2(6), PVRL3(4), RAC2(1), RAC3(1), SMAD2(2), SMAD3(2), SMAD4(3), SNAI1(1), SNAI2(3), SORBS1(3), SRC(3), SSX2IP(3), TCF7L1(2), TCF7L2(1), TGFBR1(1), TGFBR2(2), TJP1(6), VCL(2), WAS(1), WASF1(1), WASF2(2), WASF3(2), YES1(2) 112608926 248 185 233 67 27 26 36 83 74 2 0.386 1.000 1.000 438 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 161 ADORA2A(5), ADORA2B(1), ADORA3(2), ADRA1A(4), ADRB2(2), AGTR1(2), AGTR2(1), AVPR1A(1), AVPR2(3), BDKRB1(1), BDKRB2(1), BRS3(2), C3AR1(3), CCKAR(4), CCKBR(3), CCR2(2), CCR3(2), CCR5(1), CCR6(1), CCR7(1), CCR9(1), CCRL2(1), CHML(1), CHRM1(2), CHRM2(6), CHRM3(3), CHRM5(2), CMKLR1(1), CNR1(1), CNR2(3), CX3CR1(1), CXCR4(1), DRD1(1), DRD2(1), DRD3(3), DRD5(4), EDNRB(3), F2R(2), F2RL1(1), F2RL2(2), F2RL3(1), FPR1(2), FSHR(2), GALR1(1), GALT(3), GPR17(2), GPR173(2), GPR174(4), GPR27(1), GPR3(1), GPR35(3), GPR37(3), GPR37L1(2), GPR4(1), GPR50(3), GPR63(1), GPR83(2), GPR85(3), GPR87(3), GRPR(2), HCRTR1(2), HCRTR2(4), HRH2(1), HRH3(2), HTR1A(2), HTR1B(1), HTR1D(2), HTR1E(3), HTR1F(2), HTR2A(1), HTR2B(1), HTR2C(1), HTR4(2), HTR6(2), HTR7(2), MAS1(1), MC1R(2), MC3R(2), MC4R(1), MC5R(1), MLNR(1), MTNR1B(1), NMUR2(6), NPY1R(1), NPY2R(2), NTSR1(3), OPN1SW(2), OPRD1(3), OPRK1(2), OPRL1(1), OPRM1(3), OR11A1(1), OR12D3(1), OR1C1(1), OR1F1(2), OR1Q1(1), OR7A5(2), OR7C1(2), OR8B8(2), OXTR(1), P2RY1(3), P2RY10(1), P2RY11(1), P2RY12(1), P2RY13(1), P2RY14(1), P2RY2(2), P2RY6(2), PTAFR(1), PTGDR(1), PTGER2(1), PTGER4(1), PTGFR(5), PTGIR(2), RHO(1), SSTR1(3), SSTR2(2), SSTR3(2), SSTR4(3), SUCNR1(1), TBXA2R(4), TRHR(2) 115278121 238 184 236 81 40 30 31 97 40 0 0.492 1.000 1.000 439 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 79 AGL(7), AMY2A(1), AMY2B(2), ASCC3(6), ATP13A2(7), DDX18(3), DDX23(3), DDX4(5), DDX41(3), DDX47(2), DDX50(9), DDX51(1), DDX52(2), DDX54(3), DDX55(3), DDX56(2), DHX58(3), ENPP1(4), ENPP3(2), ENTPD7(3), EP400(14), ERCC2(1), ERCC3(4), G6PC(3), GAA(3), GANC(3), GBA(3), GBE1(1), GCK(2), GUSB(5), GYS1(3), GYS2(3), HK1(6), IFIH1(3), MGAM(8), MOV10L1(6), NUDT5(4), PGM1(1), PYGB(3), PYGL(2), PYGM(4), RAD54B(1), RAD54L(2), RUVBL2(3), SETX(10), SI(9), SKIV2L2(2), SMARCA2(5), SMARCA5(4), UGDH(1), UGP2(1), UGT1A1(5), UGT1A3(1), UGT1A4(2), UGT1A5(2), UGT1A6(3), UGT1A7(3), UGT1A9(5), UGT2A1(3), UGT2A3(3), UGT2B11(2), UGT2B15(1), UGT2B17(1), UGT2B28(5), UGT2B4(4), UGT2B7(6), UXS1(1) 122997694 238 181 234 76 18 28 42 85 64 1 0.780 1.000 1.000 440 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(1), ACTA2(1), ACTN2(3), ACTN4(3), DES(1), DMD(14), MYBPC1(5), MYBPC2(3), MYBPC3(2), MYH3(6), MYH6(7), MYH7(13), MYH8(6), MYL1(4), MYL2(1), MYL9(1), MYOM1(6), NEB(22), TCAP(1), TMOD1(6), TNNI1(2), TNNT1(2), TNNT2(1), TNNT3(1), TPM2(1), TPM3(1), TPM4(1), TTN(111), VIM(2) 140734031 228 180 222 69 20 37 27 90 50 4 0.555 1.000 1.000 441 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 106 ABL1(8), ANAPC1(4), ANAPC10(1), ANAPC2(2), ANAPC4(6), ANAPC5(3), ANAPC7(2), ATM(19), ATR(12), BUB1(2), BUB1B(1), BUB3(1), CCNA1(7), CCNB1(1), CCNB2(6), CCNB3(4), CCND2(1), CCNE1(2), CCNE2(4), CCNH(1), CDC14A(5), CDC14B(1), CDC16(4), CDC20(3), CDC23(2), CDC25A(1), CDC25B(1), CDC25C(3), CDC6(2), CDC7(2), CDK2(2), CDK4(6), CDK6(1), CDKN1A(3), CDKN1B(1), CDKN2C(1), CHEK1(1), CHEK2(2), CREBBP(9), CUL1(5), E2F1(1), E2F2(1), E2F3(1), EP300(16), ESPL1(12), FZR1(3), GADD45B(1), GSK3B(3), HDAC1(2), MAD1L1(1), MAD2L1(1), MCM2(10), MCM3(1), MCM4(1), MCM5(3), MCM6(5), MCM7(6), PCNA(3), PKMYT1(1), PLK1(1), PRKDC(12), RB1(4), RBL2(5), RBX1(1), SFN(1), SKP2(1), SMAD2(2), SMAD3(2), SMAD4(3), SMC1A(4), SMC1B(4), TGFB2(2), WEE1(2), YWHAB(1) 133986462 259 178 244 66 21 29 38 82 85 4 0.219 1.000 1.000 442 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 109 ACTN1(1), ACTN2(3), ACTN4(3), ARHGAP5(6), BCAR1(6), CD99(1), CDC42(1), CDH5(4), CLDN10(2), CLDN11(1), CLDN15(1), CLDN16(2), CLDN18(2), CLDN2(1), CLDN23(1), CLDN4(2), CLDN6(1), CLDN7(1), CTNNA1(7), CTNNA2(7), CTNNA3(3), CTNNB1(2), CTNND1(5), CXCR4(1), ESAM(3), EZR(2), F11R(1), GNAI1(2), GNAI2(2), GNAI3(1), ICAM1(3), ITGA4(3), ITGAL(7), ITGAM(9), ITGB1(7), ITGB2(2), ITK(1), JAM3(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(1), MLLT4(11), MMP2(6), MMP9(1), MSN(3), MYL2(1), MYL7(2), MYL9(1), NCF1(1), NCF2(1), NOX1(7), NOX3(6), OCLN(3), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PLCG1(4), PLCG2(4), PRKCA(2), PRKCG(6), PTK2(3), PTK2B(3), PTPN11(2), PXN(3), RAC2(1), RAP1A(1), RAPGEF3(2), RAPGEF4(2), ROCK1(5), ROCK2(3), SIPA1(4), TXK(1), VAV1(4), VAV2(4), VAV3(1), VCAM1(6), VCL(2) 121982234 242 177 234 71 30 29 30 88 64 1 0.616 1.000 1.000 443 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY1(2), ADCY2(7), ADCY3(6), ADCY4(3), ADCY5(7), ADCY6(2), ADCY7(1), ADCY8(12), ADCY9(7), AKAP1(3), AKAP10(2), AKAP11(3), AKAP12(7), AKAP2(2), AKAP3(3), AKAP4(2), AKAP5(1), AKAP6(5), AKAP7(1), AKAP8(2), AKAP9(21), ARHGEF1(2), CALM2(1), CHMP1B(2), GNA11(1), GNA12(1), GNA13(4), GNA15(1), GNAI2(2), GNAI3(1), GNAO1(1), GNAZ(3), GNB1(3), GNB3(2), GNB5(2), GNG10(1), GNG12(1), GNG3(1), GNG7(1), HRAS(1), IL18BP(1), ITPR1(7), KCNJ3(4), KRAS(3), NRAS(2), PALM2(1), PDE1A(1), PDE1B(5), PDE1C(2), PDE4A(2), PDE4B(1), PDE4C(7), PDE4D(1), PDE7A(1), PDE7B(1), PDE8A(2), PDE8B(2), PLCB3(3), PPP3CA(3), PPP3CC(3), PRKACA(2), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PRKCA(2), PRKCD(5), PRKCE(4), PRKCG(6), PRKCH(4), PRKCI(5), PRKCQ(5), PRKCZ(1), PRKD1(4), PRKD3(4), SLC9A1(3), USP5(4) 117000085 241 175 234 69 24 36 14 91 75 1 0.550 1.000 1.000 444 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 80 ACVR1(1), ACVR1B(3), ACVRL1(1), AKT1(2), AURKB(1), BMPR1A(1), BMPR2(5), BUB1(2), CDKL1(1), CDKL2(4), CDS2(2), CLK1(5), CLK2(2), CLK4(5), COL4A3BP(3), CSNK2A1(3), CSNK2A2(2), CSNK2B(1), DGKA(4), DGKB(3), DGKD(3), DGKE(5), DGKG(5), DGKH(6), DGKQ(3), DGKZ(5), IMPA1(1), INPP4A(2), INPP4B(4), INPP5A(1), INPPL1(4), ITPKA(1), ITPKB(3), MAP3K10(4), MOS(1), NEK1(3), NEK3(3), OCRL(3), PAK4(3), PIK3C2A(6), PIK3C2B(5), PIK3C2G(4), PIK3CB(5), PIK3CG(4), PLCB1(3), PLCB2(4), PLCB3(3), PLCB4(5), PLCD1(3), PLCG1(4), PLCG2(4), PLK3(2), PRKACA(2), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PRKCA(2), PRKCD(5), PRKCE(4), PRKCG(6), PRKCH(4), PRKCQ(5), PRKCZ(1), PRKD1(4), PRKG1(4), RAF1(4), RPS6KA3(3), RPS6KA4(2), RPS6KB1(2), STK11(2), TGFBR1(1), VRK1(1) 110028100 225 171 223 51 22 32 20 76 75 0 0.0876 1.000 1.000 445 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 84 ABL1(8), ABL2(5), AKT1(2), AKT2(5), AKT3(3), ARAF(1), AREG(1), BAD(1), BRAF(4), BTC(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CBL(3), CBLB(4), CBLC(2), CDKN1A(3), CDKN1B(1), CRKL(1), EGF(5), EGFR(9), EIF4EBP1(1), ELK1(1), ERBB2(8), ERBB3(6), ERBB4(10), GAB1(2), GRB2(2), GSK3B(3), HRAS(1), JUN(2), KRAS(3), MAP2K2(1), MAP2K7(1), MAPK10(2), MAPK3(3), MAPK9(2), MYC(1), NCK1(1), NCK2(2), NRAS(2), NRG1(3), NRG2(3), NRG3(5), PAK1(3), PAK2(4), PAK3(1), PAK4(3), PAK6(5), PAK7(3), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PLCG1(4), PLCG2(4), PRKCA(2), PRKCG(6), PTK2(3), RAF1(4), RPS6KB1(2), RPS6KB2(2), SHC1(4), SHC2(4), SHC3(1), SHC4(1), SOS1(8), SOS2(7), SRC(3), STAT5A(3), STAT5B(3), TGFA(1) 100063974 233 170 224 50 22 32 38 85 54 2 0.0341 1.000 1.000 446 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 71 CALM2(1), CDS2(2), DGKA(4), DGKB(3), DGKD(3), DGKE(5), DGKG(5), DGKH(6), DGKI(1), DGKQ(3), DGKZ(5), FN3K(1), IMPA1(1), IMPA2(3), INPP4A(2), INPP4B(4), INPP5A(1), INPP5B(5), INPP5D(2), INPP5E(2), INPPL1(4), ITPK1(2), ITPKA(1), ITPKB(3), ITPR1(7), ITPR2(12), ITPR3(5), OCRL(3), PI4KA(10), PI4KB(3), PIK3C2A(6), PIK3C2B(5), PIK3C2G(4), PIK3C3(4), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PIP4K2A(4), PIP4K2B(2), PIP4K2C(3), PIP5K1A(2), PIP5K1B(1), PIP5K1C(4), PLCB1(3), PLCB2(4), PLCB3(3), PLCB4(5), PLCD1(3), PLCD3(1), PLCD4(3), PLCE1(6), PLCG1(4), PLCG2(4), PLCZ1(3), PRKCA(2), PRKCG(6), PTPMT1(1), SYNJ1(6), SYNJ2(5) 122610042 226 168 220 69 25 36 23 78 63 1 0.614 1.000 1.000 447 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 43 ABCA1(9), ABCA10(6), ABCA12(14), ABCA13(22), ABCA2(3), ABCA3(4), ABCA4(11), ABCA5(8), ABCA6(5), ABCA7(11), ABCA8(6), ABCA9(3), ABCB1(4), ABCB10(1), ABCB11(4), ABCB4(8), ABCB5(5), ABCB6(3), ABCB7(1), ABCB8(1), ABCB9(2), ABCC10(7), ABCC11(7), ABCC12(3), ABCC2(4), ABCC3(8), ABCC4(7), ABCC5(5), ABCC6(7), ABCC8(5), ABCC9(4), ABCD1(3), ABCD2(2), ABCD3(2), ABCD4(4), ABCG1(1), ABCG2(2), ABCG4(7), ABCG5(3), ABCG8(5), CFTR(8), TAP1(1), TAP2(1) 115209665 227 167 219 70 15 34 33 92 52 1 0.516 1.000 1.000 448 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 91 AKT1(2), AKT2(5), AKT3(3), BCL10(1), CARD11(10), CBL(3), CBLB(4), CBLC(2), CD28(1), CD3E(1), CD3G(2), CD8A(1), CDC42(1), CDK4(6), CHUK(2), CTLA4(3), FOS(1), FYN(2), GRAP2(1), GRB2(2), HRAS(1), ICOS(3), IKBKB(3), IL4(1), ITK(1), JUN(2), KRAS(3), LCK(1), LCP2(3), MALT1(2), MAP3K8(1), NCK1(1), NCK2(2), NFAT5(8), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), NFKB1(2), NFKB2(3), NFKBIA(2), NFKBIB(2), NRAS(2), PAK1(3), PAK2(4), PAK3(1), PAK4(3), PAK6(5), PAK7(3), PDCD1(1), PDK1(1), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PLCG1(4), PPP3CA(3), PPP3CC(3), PRKCQ(5), PTPN6(3), PTPRC(8), RASGRP1(3), SOS1(8), SOS2(7), TEC(5), TNF(1), VAV1(4), VAV2(4), VAV3(1), ZAP70(1) 97655632 222 166 212 38 20 27 31 87 57 0 0.00461 1.000 1.000 449 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 99 ADCY1(2), ADCY2(7), ADCY3(6), ADCY4(3), ADCY5(7), ADCY6(2), ADCY7(1), ADCY8(12), ADCY9(7), ASIP(1), CALM2(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CREB3L1(1), CREB3L2(1), CREB3L3(1), CREB3L4(3), CREBBP(9), CTNNB1(2), DCT(4), DVL1(1), DVL2(1), EDNRB(3), EP300(16), FZD1(3), FZD10(4), FZD2(2), FZD3(1), FZD4(4), FZD5(2), FZD7(1), GNAI1(2), GNAI2(2), GNAI3(1), GNAO1(1), GNAS(6), GSK3B(3), HRAS(1), KITLG(2), KRAS(3), LEF1(3), MAP2K2(1), MAPK3(3), MC1R(2), MITF(5), NRAS(2), PLCB1(3), PLCB2(4), PLCB3(3), PLCB4(5), POMC(2), PRKACA(2), PRKACB(2), PRKACG(2), PRKCA(2), PRKCG(6), PRKX(2), RAF1(4), TCF7L1(2), TCF7L2(1), TYR(5), TYRP1(4), WNT1(2), WNT10A(3), WNT10B(1), WNT11(1), WNT2(2), WNT2B(2), WNT3(3), WNT3A(1), WNT5B(2), WNT7B(1), WNT8A(3), WNT8B(1), WNT9B(1) 106042160 222 166 214 58 28 27 25 87 55 0 0.185 1.000 1.000 450 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 75 ABL1(8), ACTN1(1), ACTR2(2), AKT1(2), AKT2(5), AKT3(3), ARHGEF6(4), ARHGEF7(5), BCAR1(6), BRAF(4), CDC42(1), CSE1L(4), DOCK1(3), EPHB2(2), FYN(2), GRB2(2), GRB7(5), ILK(4), ITGA1(8), ITGA10(4), ITGA11(6), ITGA2(4), ITGA3(6), ITGA4(3), ITGA5(5), ITGA6(6), ITGA7(6), ITGA8(3), ITGA9(3), ITGB3BP(1), MAP2K7(1), MAP3K11(1), MAPK10(2), MAPK8IP1(4), MAPK8IP2(1), MAPK8IP3(2), MAPK9(2), MRAS(1), MYLK(4), MYLK2(1), P4HB(3), PAK1(3), PAK2(4), PAK3(1), PAK4(3), PAK6(5), PAK7(3), PIK3CB(5), PKLR(1), PLCG1(4), PLCG2(4), PTK2(3), RAF1(4), RALA(2), RHO(1), ROCK1(5), ROCK2(3), SHC1(4), SOS1(8), SOS2(7), SRC(3), TLN1(13), TLN2(11), WAS(1), ZYX(1) 118716011 239 165 232 68 16 34 33 88 65 3 0.526 1.000 1.000 451 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CD2BP2(1), CDC40(3), CLK2(2), CLK3(2), CLK4(5), COL2A1(6), CPSF1(4), CPSF2(2), CPSF3(5), CPSF4(2), CSTF2T(2), CSTF3(4), DDX1(1), DDX20(7), DHX15(2), DHX16(3), DHX38(3), DHX8(3), DHX9(6), DICER1(5), FUS(5), GIPC1(3), METTL3(4), NONO(2), NUDT21(1), NXF1(1), PAPOLA(3), PHF5A(1), POLR2A(13), PPM1G(2), PRPF18(2), PRPF3(2), PRPF4B(7), PRPF8(14), PSKH1(1), PTBP1(1), PTBP2(1), RBM17(3), RBM5(2), RNMT(4), RNPS1(1), SF3A1(2), SF3A3(1), SF3B1(16), SF3B2(5), SF3B4(1), SNRPA(1), SNRPB(2), SNRPB2(1), SNRPE(1), SNRPN(2), SPOP(1), SRPK2(2), SRRM1(5), SUPT5H(7), TXNL4A(1), U2AF2(3), XRN2(3) 105751759 195 162 190 43 19 39 19 69 48 1 0.0766 1.000 1.000 452 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 65 A2M(8), BDKRB1(1), BDKRB2(1), C1QA(1), C1QC(1), C1R(4), C2(4), C3(8), C3AR1(3), C4BPA(3), C4BPB(3), C5(6), C5AR1(3), C6(3), C7(4), C8A(1), C8B(1), C8G(2), CD46(1), CD55(2), CD59(1), CFB(3), CFH(5), CFI(2), CPB2(6), CR1(8), CR2(4), F10(1), F11(2), F12(7), F13A1(3), F13B(4), F2(3), F2R(2), F5(11), F7(1), F8(8), F9(2), FGA(4), FGB(3), FGG(6), KLKB1(2), KNG1(4), MASP1(4), MASP2(1), MBL2(2), PLAT(4), PLAUR(2), PLG(8), PROC(3), PROS1(5), SERPINA1(3), SERPIND1(3), SERPINF2(2), SERPING1(2), TFPI(2), THBD(1), VWF(15) 88615845 209 161 201 42 24 25 23 87 47 3 0.0153 1.000 1.000 453 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 105 A4GNT(3), ALG1(1), ALG10(3), ALG10B(8), ALG11(4), ALG12(2), ALG13(5), ALG14(1), ALG3(3), ALG6(3), ALG8(1), ALG9(2), B3GNT1(2), B3GNT2(3), B3GNT6(4), B3GNT7(1), B4GALT1(1), B4GALT3(2), B4GALT4(2), B4GALT5(2), CHPF(1), CHST1(2), CHST11(1), CHST12(2), CHST14(1), CHST2(2), CHST3(2), CHST4(1), CHST6(2), CHST7(2), EXT1(3), EXT2(1), EXTL1(1), EXTL3(3), FUT11(4), GALNT1(1), GALNT10(7), GALNT11(3), GALNT13(3), GALNT14(3), GALNT2(2), GALNT4(3), GALNT5(6), GALNT6(5), GALNT7(7), GALNT8(1), GALNT9(1), GALNTL5(3), GCNT1(2), GCNT3(2), GCNT4(3), HS2ST1(2), HS3ST2(2), HS3ST3A1(1), HS3ST5(1), HS6ST1(3), HS6ST2(3), HS6ST3(1), MAN1A1(2), MAN1A2(1), MAN1B1(1), MAN2A1(3), MGAT2(1), MGAT3(1), MGAT4A(3), MGAT4B(1), MGAT5(4), MGAT5B(4), NDST1(2), NDST2(4), NDST3(1), NDST4(7), OGT(5), RPN1(3), RPN2(1), ST3GAL1(2), ST3GAL3(3), ST3GAL4(2), ST6GAL1(1), ST6GALNAC1(2), STT3B(4), UST(1), WBSCR17(5), XYLT1(5), XYLT2(2) 104876799 217 159 210 66 21 32 26 69 69 0 0.667 1.000 1.000 454 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 66 ADCY1(2), ADCY8(12), ARAF(1), ATF4(2), BRAF(4), CACNA1C(17), CALM2(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(3), CREBBP(9), EP300(16), GRIA1(8), GRIA2(4), GRIN1(2), GRIN2A(8), GRIN2B(8), GRIN2D(2), GRM1(4), GRM5(8), HRAS(1), ITPR1(7), ITPR2(12), ITPR3(5), KRAS(3), MAP2K2(1), MAPK3(3), NRAS(2), PLCB1(3), PLCB2(4), PLCB3(3), PLCB4(5), PPP1CA(1), PPP1CC(2), PPP1R12A(3), PPP1R1A(1), PPP3CA(3), PPP3CC(3), PRKACA(2), PRKACB(2), PRKACG(2), PRKCA(2), PRKCG(6), PRKX(2), RAF1(4), RAP1A(1), RAPGEF3(2), RPS6KA3(3), RPS6KA6(1) 99425787 205 156 196 56 26 30 23 74 51 1 0.247 1.000 1.000 455 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 85 ACVR1(1), ACVR1B(3), ACVR1C(3), ACVR2A(4), ACVR2B(1), ACVRL1(1), BMP2(1), BMP4(1), BMP5(1), BMP6(1), BMP7(5), BMP8B(1), BMPR1A(1), BMPR1B(2), BMPR2(5), CHRD(5), CREBBP(9), CUL1(5), DCN(3), E2F5(1), EP300(16), GDF5(5), GDF6(2), GDF7(1), INHBA(2), INHBB(2), INHBC(1), INHBE(1), LEFTY1(1), LEFTY2(1), LTBP1(8), MAPK3(3), MYC(1), NODAL(2), NOG(2), PITX2(2), PPP2CA(1), PPP2CB(2), PPP2R1A(2), PPP2R1B(2), PPP2R2A(6), PPP2R2B(3), PPP2R2C(3), RBL2(5), RBX1(1), ROCK1(5), ROCK2(3), RPS6KB1(2), RPS6KB2(2), SMAD1(1), SMAD2(2), SMAD3(2), SMAD4(3), SMAD5(1), SMAD6(1), SMAD7(1), SMAD9(1), SMURF1(1), SMURF2(3), SP1(2), TGFB2(2), TGFBR1(1), TGFBR2(2), THBS2(3), THBS3(5), THBS4(2), TNF(1), ZFYVE16(1), ZFYVE9(6) 93514179 182 146 178 43 21 17 31 60 53 0 0.108 1.000 1.000 456 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 83 ANPEP(8), CD19(1), CD1A(1), CD1B(1), CD1C(2), CD1D(2), CD1E(2), CD2(2), CD22(4), CD33(3), CD34(2), CD36(1), CD38(1), CD3E(1), CD3G(2), CD44(3), CD5(1), CD55(2), CD59(1), CD8A(1), CR1(8), CR2(4), CSF1R(6), CSF2RA(3), CSF3R(3), DNTT(4), EPOR(3), FCER2(1), FCGR1A(2), FLT3(6), GP9(1), HLA-DRA(1), HLA-DRB1(6), HLA-DRB5(8), IL11RA(2), IL1B(1), IL1R1(3), IL1R2(8), IL2RA(2), IL3(1), IL4(1), IL4R(4), IL5RA(2), IL6R(2), IL7R(1), IL9R(6), ITGA1(8), ITGA2(4), ITGA2B(1), ITGA3(6), ITGA4(3), ITGA5(5), ITGA6(6), ITGAM(9), ITGB3(3), KITLG(2), MME(5), MS4A1(1), TFRC(3), THPO(1), TNF(1), TPO(4) 80607770 192 146 182 40 15 17 27 68 64 1 0.138 1.000 1.000 457 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 90 BAD(1), CABIN1(11), CALM2(1), CAMK2B(1), CAMK4(3), CD3E(1), CD3G(2), CDKN1A(3), CNR1(1), CREBBP(9), CSNK2A1(3), CSNK2B(1), CTLA4(3), EGR2(1), EGR3(2), EP300(16), FOS(1), GATA3(2), GATA4(2), GSK3A(2), GSK3B(3), HRAS(1), ICOS(3), IFNA1(1), IFNB1(2), IL1B(1), IL2RA(2), IL3(1), IL4(1), ITK(1), JUNB(2), MAP2K7(1), MAPK14(1), MAPK9(2), MEF2A(2), MEF2D(1), NCK2(2), NFAT5(8), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), NFKB2(3), NFKBIB(2), NPPB(1), NUP214(8), OPRD1(3), P2RX7(2), PAK1(3), PPIA(1), PPP3CC(3), PTPRC(8), RELA(6), SFN(1), SLA(1), SP1(2), SP3(2), TNF(1), TRAF2(1), TRPV6(5), VAV1(4), VAV2(4), VAV3(1), XPO5(3) 88775783 188 143 177 47 19 20 28 60 59 2 0.327 1.000 1.000 458 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 80 ABL1(8), ATM(19), BUB1(2), BUB1B(1), BUB3(1), CCNA1(7), CCNB1(1), CCNB2(6), CCNB3(4), CCND2(1), CCNE1(2), CCNE2(4), CCNH(1), CDAN1(6), CDC14A(5), CDC14B(1), CDC20(3), CDC25A(1), CDC25B(1), CDC25C(3), CDC6(2), CDC7(2), CDH1(2), CDK2(2), CDK4(6), CDKN1A(3), CHEK1(1), CHEK2(2), DTX4(5), E2F1(1), E2F2(1), E2F3(1), E2F5(1), EP300(16), ESPL1(12), GSK3B(3), HDAC1(2), HDAC4(1), HDAC5(3), HDAC6(3), HDAC8(1), MAD1L1(1), MAD2L1(1), MCM2(10), MCM3(1), MCM4(1), MCM5(3), MCM6(5), MCM7(6), MPEG1(1), PCNA(3), PLK1(1), PRKDC(12), PTPRA(5), RB1(4), SKP2(1), SMAD4(3), TBC1D8(1), WEE1(2) 109835501 208 142 195 55 18 25 33 67 61 4 0.251 1.000 1.000 459 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 56 ASH1L(7), ASH2L(3), CTCFL(5), DOT1L(9), EED(1), EHMT1(4), EHMT2(8), EZH1(2), EZH2(4), FBXO11(5), HCFC1(8), HSF4(3), JMJD4(1), JMJD6(4), KDM6A(10), MEN1(1), NSD1(13), OGT(5), PAXIP1(4), PPP1CA(1), PPP1CC(2), PRDM2(4), PRDM6(1), PRDM7(3), PRDM9(8), PRMT5(3), PRMT6(2), PRMT7(2), PRMT8(3), RBBP5(5), SATB1(4), SETD1A(8), SETD1B(1), SETD7(1), SETDB1(6), SETMAR(2), SMYD3(2), SUV39H2(5), SUV420H1(3), SUZ12(6), WHSC1(5), WHSC1L1(5) 116505608 179 139 178 48 15 27 22 59 55 1 0.352 1.000 1.000 460 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 98 AKT1(2), AKT2(5), AKT3(3), CASP8(1), CCL3(1), CD40(1), CD80(1), CD86(3), CHUK(2), CXCL11(1), CXCL9(1), FOS(1), IFNA1(1), IFNA14(1), IFNA16(2), IFNA2(1), IFNA21(3), IFNA5(1), IFNA7(3), IFNA8(2), IFNAR1(3), IFNB1(2), IKBKB(3), IKBKE(3), IL1B(1), IRAK1(3), IRAK4(1), IRF5(3), IRF7(1), JUN(2), LBP(1), LY96(1), MAP2K2(1), MAP2K3(3), MAP2K7(1), MAP3K7(3), MAP3K8(1), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(3), MAPK9(2), NFKB1(2), NFKB2(3), NFKBIA(2), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), RELA(6), RIPK1(1), SPP1(3), STAT1(5), TBK1(3), TICAM1(3), TLR1(3), TLR2(2), TLR3(1), TLR4(3), TLR5(4), TLR6(2), TLR7(5), TLR8(5), TLR9(1), TNF(1), TRAF3(1), TRAF6(2) 86343029 161 133 156 37 17 19 21 73 29 2 0.153 1.000 1.000 461 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 68 ACACB(5), ACSL1(4), ACSL4(1), ACSL5(1), ACSL6(5), AKT1(2), AKT2(5), AKT3(3), CAMKK1(4), CAMKK2(3), CD36(1), CHUK(2), CPT1A(2), CPT1C(4), CPT2(2), G6PC(3), IKBKB(3), IRS1(5), IRS4(1), JAK1(6), JAK2(7), JAK3(4), LEP(1), LEPR(5), MAPK10(2), MAPK9(2), NFKB1(2), NFKB2(3), NFKBIA(2), NFKBIB(2), NPY(1), PCK1(5), PCK2(2), POMC(2), PPARGC1A(4), PRKAA1(1), PRKAB1(1), PRKAG1(5), PRKAG2(6), PRKAG3(1), PRKCQ(5), PTPN11(2), RELA(6), RXRB(4), RXRG(2), SLC2A1(2), SLC2A4(2), SOCS3(1), STAT3(3), STK11(2), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TRADD(2), TRAF2(1), TYK2(7) 78519789 162 132 156 42 14 22 29 49 47 1 0.354 1.000 1.000 462 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 83 ATF2(2), BRAF(4), CHUK(2), DAXX(6), ELK1(1), FOS(1), GRB2(2), HRAS(1), IKBKB(3), JUN(2), MAP2K2(1), MAP2K3(3), MAP2K5(3), MAP2K7(1), MAP3K1(7), MAP3K10(4), MAP3K11(1), MAP3K12(4), MAP3K13(2), MAP3K2(2), MAP3K3(2), MAP3K4(7), MAP3K5(5), MAP3K6(3), MAP3K7(3), MAP3K8(1), MAP3K9(5), MAP4K1(4), MAP4K3(6), MAP4K4(2), MAP4K5(4), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(3), MAPK4(2), MAPK6(1), MAPK7(4), MAPK9(2), MAPKAPK2(1), MAX(5), MEF2A(2), MEF2D(1), MKNK1(2), MKNK2(1), MYC(1), NFKB1(2), NFKBIA(2), PAK1(3), PAK2(4), RAF1(4), RELA(6), RIPK1(1), RPS6KA3(3), RPS6KA4(2), RPS6KA5(2), RPS6KB1(2), RPS6KB2(2), SHC1(4), SP1(2), STAT1(5), TGFB2(2), TGFBR1(1), TRADD(2), TRAF2(1) 94445350 175 130 169 42 18 18 19 64 53 3 0.326 1.000 1.000 463 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 62 AKT1(2), AKT2(5), AKT3(3), BCL10(1), BLNK(1), CARD11(10), CD19(1), CD22(4), CD72(1), CD81(1), CHUK(2), CR2(4), FOS(1), GSK3B(3), HRAS(1), IFITM1(1), IKBKB(3), INPP5D(2), JUN(2), KRAS(3), LILRB3(4), LYN(1), MALT1(2), NFAT5(8), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), NFKB1(2), NFKB2(3), NFKBIA(2), NFKBIB(2), NRAS(2), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PLCG2(4), PPP3CA(3), PPP3CC(3), PTPN6(3), RAC2(1), RAC3(1), RASGRP3(2), SYK(2), VAV1(4), VAV2(4), VAV3(1) 71797497 150 125 141 36 17 18 15 58 42 0 0.252 1.000 1.000 464 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 57 AKT1(2), AKT2(5), AKT3(3), BAD(1), CDC42(1), CDK2(2), CDKN1B(1), CREB5(3), ERBB4(10), F2RL2(2), GAB1(2), GRB2(2), GSK3A(2), GSK3B(3), IGFBP1(1), INPPL1(4), IRS1(5), IRS4(1), MYC(1), NOLC1(2), PAK1(3), PAK2(4), PAK3(1), PAK4(3), PAK6(5), PAK7(3), PARD3(6), PDK1(1), PIK3CD(2), PPP1R13B(4), PREX1(8), PTK2(3), PTPN1(2), RPS6KA3(3), RPS6KB1(2), SFN(1), SHC1(4), SLC2A4(2), SOS1(8), SOS2(7), TSC1(5), TSC2(12), YWHAB(1) 67270759 143 122 139 33 16 20 24 41 39 3 0.0868 1.000 1.000 465 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 68 AKT1(2), AKT2(5), AKT3(3), BAD(1), CASP9(2), CDC42(1), HRAS(1), KDR(6), KRAS(3), MAP2K2(1), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(3), MAPKAPK2(1), NFAT5(8), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), NOS3(3), NRAS(2), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(4), PLCG1(4), PLCG2(4), PPP3CA(3), PPP3CC(3), PRKCA(2), PRKCG(6), PTGS2(5), PTK2(3), PXN(3), RAC2(1), RAC3(1), RAF1(4), SH2D2A(3), SHC2(4), SPHK1(1), SPHK2(1), SRC(3), VEGFA(1) 68975748 152 121 147 43 14 20 20 60 38 0 0.516 1.000 1.000 466 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 42 ADAM17(2), APH1A(1), CREBBP(9), CTBP1(2), CTBP2(1), DLL1(1), DLL3(1), DLL4(2), DTX1(5), DTX3(1), DTX3L(2), DTX4(5), DVL1(1), DVL2(1), EP300(16), HDAC1(2), JAG1(9), JAG2(4), MAML1(9), MAML2(6), MAML3(8), NCOR2(6), NCSTN(2), NOTCH1(12), NOTCH2(14), NOTCH3(11), NOTCH4(6), NUMB(3), NUMBL(1), PSEN2(2), PSENEN(1), PTCRA(2), RBPJ(4), SNW1(3) 65175755 155 119 149 74 17 18 18 45 53 4 1.000 1.000 1.000 467 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 73 AKT1(2), AKT2(5), AKT3(3), FCER1G(1), FYN(2), GAB2(2), GRB2(2), HRAS(1), IL3(1), IL4(1), INPP5D(2), KRAS(3), LCP2(3), LYN(1), MAP2K2(1), MAP2K3(3), MAP2K7(1), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(3), MAPK9(2), MS4A2(1), NRAS(2), PDK1(1), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R5(4), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(4), PLCG1(4), PLCG2(4), PRKCA(2), PRKCD(5), PRKCE(4), RAC2(1), RAC3(1), RAF1(4), SOS1(8), SOS2(7), SYK(2), TNF(1), VAV1(4), VAV2(4), VAV3(1) 69832961 133 118 130 41 13 22 21 53 24 0 0.506 1.000 1.000 468 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 AICDA(3), CAD(12), CANT1(1), DCK(1), DCTD(1), DPYD(5), DPYS(4), DTYMK(1), ENTPD1(1), ENTPD5(3), ENTPD6(2), NME7(2), NT5C1A(2), NT5C1B(2), NT5C2(1), NT5M(2), PNPT1(2), POLA1(4), POLD1(7), POLD3(1), POLE(5), POLE2(1), POLR1A(6), POLR1B(4), POLR1C(2), POLR1D(1), POLR2A(13), POLR2B(7), POLR2F(4), POLR2I(1), POLR2J(1), POLR3A(5), POLR3B(5), POLR3G(1), POLR3H(1), POLR3K(1), PRIM1(3), PRIM2(4), RFC5(3), RRM1(2), RRM2(1), TK1(1), TK2(2), TXNRD1(2), TXNRD2(1), TYMS(1), UCK1(1), UCK2(1), UMPS(1), UPB1(1), UPP1(2), UPP2(2), UPRT(3) 81728932 146 116 137 34 12 23 17 48 44 2 0.159 1.000 1.000 469 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(3), ALPL(4), ALPP(5), ALPPL2(5), ASCC3(6), ATP13A2(7), DDX18(3), DDX23(3), DDX4(5), DDX41(3), DDX47(2), DDX50(9), DDX51(1), DDX52(2), DDX54(3), DDX55(3), DDX56(2), DHX58(3), ENTPD7(3), EP400(14), ERCC2(1), ERCC3(4), FPGS(3), GGH(2), IFIH1(3), MOV10L1(6), NUDT5(4), PTS(1), QDPR(1), RAD54B(1), RAD54L(2), RUVBL2(3), SETX(10), SKIV2L2(2), SMARCA2(5), SMARCA5(4) 62195910 138 116 135 41 10 23 26 46 32 1 0.372 1.000 1.000 470 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 45 AKT1(2), AKT2(5), AKT3(3), BAD(1), BCR(1), BLNK(1), CD19(1), CD22(4), CD81(1), CR2(4), CSK(4), DAG1(3), FLOT2(1), GRB2(2), GSK3A(2), GSK3B(3), INPP5D(2), ITPR1(7), ITPR2(12), ITPR3(5), LYN(1), MAP4K1(4), MAPK3(3), NFATC1(4), NFATC2(8), PDK1(1), PIK3CD(2), PIK3R1(5), PLCG2(4), PPP1R13B(4), PPP3CA(3), PPP3CC(3), PTPRC(8), RAF1(4), SHC1(4), SOS1(8), SOS2(7), SYK(2), VAV1(4) 70970293 143 115 137 32 16 19 23 44 41 0 0.109 1.000 1.000 471 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(8), ATP4A(6), ATP5A1(3), ATP5B(3), ATP5C1(1), ATP5E(1), ATP5F1(1), ATP5G2(1), ATP5L(1), ATP6AP1(4), ATP6V0A1(3), ATP6V0A2(2), ATP6V0A4(4), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(4), ATP6V1B2(4), ATP6V1D(1), ATP6V1G1(1), COX10(5), COX15(3), COX17(1), COX5A(1), COX6B2(1), COX7A1(2), COX8A(1), CYC1(1), NDUFA1(1), NDUFA10(1), NDUFA11(2), NDUFA13(2), NDUFA3(1), NDUFA6(1), NDUFB10(1), NDUFB11(1), NDUFB2(2), NDUFB4(1), NDUFB5(3), NDUFB6(1), NDUFB7(1), NDUFC1(2), NDUFS1(8), NDUFS2(1), NDUFS3(3), NDUFS5(1), NDUFS6(2), NDUFS7(1), NDUFS8(1), NDUFV1(2), NDUFV2(1), PPA2(2), SDHA(9), SDHB(1), SDHD(2), TCIRG1(2), UQCRC1(1), UQCRC2(2), UQCRFS1(2) 55948858 131 114 129 33 13 17 21 49 30 1 0.236 1.000 1.000 472 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 51 ADORA3(2), ALG6(3), CCKBR(3), CCR2(2), CCR3(2), CCR5(1), CELSR1(17), CELSR2(9), CELSR3(10), CHRM2(6), CHRM3(3), CIDEB(2), EMR2(4), EMR3(9), F2R(2), FSHR(2), GPR116(5), GPR133(7), GPR135(2), GPR143(1), GPR17(2), GPR18(2), GPR55(1), GPR56(1), GPR61(1), GPR84(3), GRM1(4), GRPR(2), HRH4(1), LGR6(2), LPHN2(4), LPHN3(9), LTB4R2(1), NTSR1(3), P2RY11(1), P2RY13(1), PTGFR(5), SMO(4), SSTR2(2), TSHR(2) 64070642 143 111 137 45 22 18 18 51 34 0 0.592 1.000 1.000 473 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 28 BRAF(4), CPEB1(3), EGFR(9), ERBB2(8), ERBB4(10), ETS1(2), ETS2(1), ETV6(2), FMN2(8), GRB2(2), KRAS(3), MAPK3(3), NOTCH1(12), NOTCH2(14), NOTCH3(11), NOTCH4(6), PIWIL1(2), PIWIL2(2), PIWIL3(4), PIWIL4(3), RAF1(4), SOS1(8), SOS2(7), SPIRE1(1), SPIRE2(2) 50297264 131 111 127 35 22 14 18 44 30 3 0.389 1.000 1.000 474 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 45 FN3K(1), IMPA1(1), IMPA2(3), INPP4A(2), INPP4B(4), INPP5A(1), INPP5B(5), INPP5E(2), INPPL1(4), IPMK(1), ITPK1(2), ITPKA(1), ITPKB(3), MINPP1(2), MIOX(2), OCRL(3), PI4KA(10), PI4KB(3), PIK3C3(4), PIK3CB(5), PIK3CD(2), PIK3CG(4), PIP4K2A(4), PIP4K2B(2), PIP4K2C(3), PIP5K1A(2), PIP5K1B(1), PIP5K1C(4), PLCB1(3), PLCB2(4), PLCB3(3), PLCB4(5), PLCD1(3), PLCD3(1), PLCD4(3), PLCE1(6), PLCG1(4), PLCG2(4), PLCZ1(3), PTPMT1(1), SYNJ1(6), SYNJ2(5) 70947574 132 107 127 44 12 17 14 45 43 1 0.895 1.000 1.000 475 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 54 BMP2(1), BMP4(1), BMP5(1), BMP6(1), BMP7(5), BMP8B(1), BTRC(2), CSNK1A1(2), CSNK1E(3), CSNK1G2(1), CSNK1G3(1), FBXW11(2), GLI1(7), GLI2(4), GLI3(7), GSK3B(3), HHIP(3), IHH(1), LRP2(24), PRKACA(2), PRKACB(2), PRKACG(2), PRKX(2), PTCH1(10), PTCH2(2), SHH(3), SMO(4), STK36(2), SUFU(3), WNT1(2), WNT10A(3), WNT10B(1), WNT11(1), WNT2(2), WNT2B(2), WNT3(3), WNT3A(1), WNT5B(2), WNT7B(1), WNT8A(3), WNT8B(1), WNT9B(1), ZIC2(1) 57495139 126 107 118 38 18 17 13 45 33 0 0.650 1.000 1.000 476 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 46 ADCY4(3), ADCY6(2), ADCY8(12), CACNA1A(14), CACNA1B(5), GNAS(6), GNB1(3), GNB3(2), GNG3(1), GRM4(6), ITPR3(5), KCNB1(2), PDE1A(1), PLCB2(4), PRKACA(2), PRKACB(2), PRKACG(2), PRKX(2), SCNN1A(4), SCNN1B(4), SCNN1G(2), TAS1R1(2), TAS1R2(8), TAS1R3(3), TAS2R10(1), TAS2R13(2), TAS2R14(1), TAS2R38(3), TAS2R39(2), TAS2R4(2), TAS2R41(1), TAS2R42(1), TAS2R46(2), TAS2R50(2), TAS2R60(1), TAS2R8(1), TAS2R9(2), TRPM5(3) 55407578 121 107 120 34 32 15 13 37 24 0 0.197 1.000 1.000 477 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 65 ADAM10(4), ADAM17(2), ATP6AP1(4), ATP6V0A1(3), ATP6V0A2(2), ATP6V0A4(4), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(4), ATP6V1B2(4), ATP6V1D(1), ATP6V1G1(1), CDC42(1), CHUK(2), CSK(4), CXCL1(1), EGFR(9), F11R(1), GIT1(3), IGSF5(5), IKBKB(3), JAM3(2), JUN(2), LYN(1), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK9(2), NFKB1(2), NFKB2(3), NFKBIA(2), NOD1(3), PAK1(3), PLCG1(4), PLCG2(4), PTPN11(2), PTPRZ1(14), RELA(6), SRC(3), TCIRG1(2), TJP1(6) 67961641 132 106 123 35 14 16 15 53 32 2 0.513 1.000 1.000 478 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 65 ACAA1(3), ACADL(3), ACADM(1), ACOX1(2), ACOX2(2), ACOX3(5), ACSL1(4), ACSL4(1), ACSL5(1), ACSL6(5), ANGPTL4(3), APOA1(1), APOA5(2), CD36(1), CPT1A(2), CPT1C(4), CPT2(2), CYP27A1(1), CYP4A11(5), CYP4A22(1), CYP8B1(3), DBI(1), EHHADH(6), FABP1(3), FABP3(1), FADS2(2), GK(1), GK2(3), HMGCS2(1), ILK(4), LPL(3), ME1(1), MMP1(1), NR1H3(2), PCK1(5), PCK2(2), PLTP(2), PPARD(1), PPARG(2), RXRB(4), RXRG(2), SCP2(3), SLC27A1(4), SLC27A2(1), SLC27A5(3), SLC27A6(7), SORBS1(3), UBC(4), UCP1(1) 62411596 125 105 119 40 11 16 17 42 38 1 0.808 1.000 1.000 479 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 72 B2M(3), CALR(2), CANX(2), CD74(1), CD8A(1), CIITA(5), CTSB(4), CTSS(1), HLA-A(6), HLA-B(10), HLA-C(11), HLA-DOA(1), HLA-DPA1(1), HLA-DPB1(3), HLA-DQA1(3), HLA-DQA2(3), HLA-DQB1(3), HLA-DRA(1), HLA-DRB1(6), HLA-DRB5(8), HLA-E(2), HLA-F(1), HSP90AA1(6), HSP90AB1(7), HSPA5(2), IFI30(1), IFNA1(1), IFNA14(1), IFNA16(2), IFNA2(1), IFNA21(3), IFNA5(1), IFNA7(3), IFNA8(2), KIR2DL3(1), KIR3DL1(3), KIR3DL2(1), KIR3DL3(3), KLRC1(3), KLRC2(3), KLRC3(2), LTA(1), NFYA(1), NFYC(2), PSME2(3), RFX5(3), RFXAP(1), TAP1(1), TAP2(1) 42078792 137 105 135 43 7 20 17 60 31 2 0.795 1.000 1.000 480 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 91 ANK2(16), B3GALT4(1), CDR1(4), DGKI(1), IL6ST(6), PIGK(1), RPL10(1), RPL11(3), RPL13(1), RPL14(1), RPL18(3), RPL18A(2), RPL19(2), RPL21(1), RPL23(1), RPL24(1), RPL26(1), RPL27(1), RPL28(1), RPL3(3), RPL30(3), RPL31(1), RPL32(1), RPL34(1), RPL38(1), RPL3L(3), RPL4(2), RPL5(3), RPL6(1), RPL7(1), RPL7A(3), RPL8(1), RPLP0(1), RPS11(1), RPS13(1), RPS14(2), RPS19(1), RPS2(2), RPS21(2), RPS24(2), RPS26(1), RPS27(1), RPS27A(1), RPS29(1), RPS3(2), RPS3A(1), RPS4Y1(1), RPS6KA3(3), RPS6KA6(1), RPS6KB1(2), RPS6KB2(2), RPS7(1), RPS8(1), RPS9(1), RPSA(1), SLC36A2(1), TBC1D10C(2), TSPAN9(1), UBA52(1), UBB(1), UBC(4) 50008845 114 104 112 33 7 13 20 43 30 1 0.630 1.000 1.000 481 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 61 ATM(19), CCNA1(7), CCNB1(1), CCND2(1), CCNE1(2), CCNE2(4), CCNG2(2), CCNH(1), CDC25A(1), CDK2(2), CDK4(6), CDKN1A(3), CDKN1B(1), CDKN2C(1), CREB3L1(1), CREB3L3(1), CREB3L4(3), E2F1(1), E2F2(1), E2F3(1), E2F5(1), GBA2(4), MCM2(10), MCM3(1), MCM4(1), MCM5(3), MCM6(5), MCM7(6), MNAT1(1), MYC(1), MYT1(5), PCNA(3), POLE(5), POLE2(1), PRIM1(3), RB1(4), RPA1(2), RPA2(1), RPA3(1), TFDP2(5), TNXB(11), WEE1(2) 70391464 135 101 126 28 14 13 15 45 45 3 0.117 1.000 1.000 482 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 62 ACSS1(3), ACSS2(7), ADH1A(2), ADH1B(2), ADH4(2), ADH5(1), ADH6(2), ADHFE1(3), AKR1A1(2), ALDH1B1(4), ALDH2(4), ALDH3A2(2), ALDH3B1(4), ALDH3B2(3), ALDH7A1(1), ALDOA(2), ALDOB(3), ALDOC(1), DLAT(2), DLD(4), ENO1(5), ENO2(1), ENO3(2), G6PC(3), GALM(3), GAPDH(4), GAPDHS(5), GCK(2), HK1(6), LDHAL6B(1), LDHB(2), LDHC(3), PDHA1(1), PDHA2(3), PDHB(1), PFKL(3), PFKM(3), PFKP(3), PGAM2(2), PGK1(3), PGK2(1), PGM1(1), PKLR(1), TPI1(2) 55703935 115 100 109 29 11 9 19 35 39 2 0.335 1.000 1.000 483 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 ACTG1(4), APAF1(3), ARHGDIB(1), BAG4(1), BID(2), BIRC2(2), BIRC3(5), CASP2(1), CASP7(1), CASP8(1), CASP9(2), CFLAR(1), CHUK(2), DAXX(6), DFFA(1), DFFB(1), GSN(5), LMNB1(3), LMNB2(1), MAP2K7(1), MAP3K1(7), MAP3K5(5), NFKB1(2), NFKBIA(2), NUMA1(6), PAK2(4), PRKCD(5), PRKDC(12), PSEN2(2), PTK2(3), RASA1(7), RB1(4), RELA(6), RIPK1(1), SPTAN1(12), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TRADD(2), TRAF2(1) 69400667 128 98 125 36 5 23 18 37 42 3 0.465 1.000 1.000 484 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT1(2), AKT2(5), AKT3(3), ASAH1(2), BRAF(4), DAG1(3), DRD2(1), EGFR(9), EPHB2(2), GRB2(2), ITPKA(1), ITPKB(3), ITPR1(7), ITPR2(12), ITPR3(5), KCNJ3(4), PI3(1), PIK3CB(5), PITX2(2), PLCB1(3), PLCB2(4), PLCB3(3), PLCB4(5), RAF1(4), RGS20(1), SHC1(4), SOS1(8), SOS2(7), SRC(3), STAT3(3) 58297991 118 95 116 28 12 18 20 38 29 1 0.129 1.000 1.000 485 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 58 APC(9), AXIN1(4), CCND2(1), CSNK1E(3), CTNNB1(2), DVL1(1), DVL2(1), FZD1(3), FZD10(4), FZD2(2), FZD3(1), FZD5(2), FZD7(1), GSK3B(3), JUN(2), LDLR(3), MAPK10(2), MAPK9(2), MYC(1), PAFAH1B1(1), PPP2R5C(3), PPP2R5E(1), PRKCA(2), PRKCD(5), PRKCE(4), PRKCG(6), PRKCH(4), PRKCI(5), PRKCQ(5), PRKCZ(1), PRKD1(4), SFRP4(2), WNT1(2), WNT10A(3), WNT10B(1), WNT11(1), WNT2(2), WNT2B(2), WNT3(3), WNT5B(2), WNT7B(1) 57268066 107 94 103 29 14 17 10 34 32 0 0.346 1.000 1.000 486 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 56 AADAT(2), ACAT1(1), ACMSD(2), ALDH1B1(4), ALDH2(4), ALDH3A2(2), ALDH7A1(1), AOC2(4), AOC3(2), AOX1(8), CAT(2), CYP1A1(1), CYP1A2(4), CYP1B1(2), DDC(3), ECHS1(3), EHHADH(6), HAAO(2), HADH(1), HADHA(4), HSD17B4(1), KYNU(3), LCMT1(1), LCMT2(4), LNX1(1), MAOA(2), MAOB(2), METTL2B(1), NFX1(3), OGDH(8), OGDHL(2), PRMT2(2), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(2), PRMT8(3), TPH1(2), TPH2(2), WARS(1), WARS2(1) 58383011 106 93 105 26 10 19 21 35 21 0 0.120 1.000 1.000 487 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 49 ACOX1(2), APOA1(1), CD36(1), CITED2(1), CREBBP(9), EHHADH(6), EP300(16), FABP1(3), HSD17B4(1), INS(1), JUN(2), LPL(3), MAPK3(3), ME1(1), MRPL11(1), MYC(1), NCOA1(3), NCOR1(7), NCOR2(6), NFKBIA(2), NR1H3(2), NR2F1(1), NRIP1(5), PIK3R1(5), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PRKCA(2), PTGS2(5), RB1(4), RELA(6), SP1(2), STAT5A(3), STAT5B(3), TNF(1) 60371809 119 93 110 47 7 14 13 40 42 3 0.984 1.000 1.000 488 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 68 ADH1A(2), ADH1B(2), ADH4(2), ADH5(1), ADH6(2), ADHFE1(3), AKR1C1(1), AKR1C2(1), AKR1C3(2), AKR1C4(1), ALDH3B1(4), ALDH3B2(3), CYP1A1(1), CYP1A2(4), CYP1B1(2), CYP2B6(1), CYP2C18(1), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP2E1(1), CYP2F1(4), CYP3A43(2), CYP3A5(1), CYP3A7(2), DHDH(5), GSTA1(1), GSTA2(1), GSTA3(1), GSTA4(1), GSTA5(1), GSTK1(1), GSTM1(2), GSTM2(1), GSTM4(1), GSTM5(1), GSTP1(2), GSTT1(2), UGT1A1(5), UGT1A3(1), UGT1A4(2), UGT1A5(2), UGT1A6(3), UGT1A7(3), UGT1A9(5), UGT2A1(3), UGT2A3(3), UGT2B11(2), UGT2B15(1), UGT2B17(1), UGT2B28(5), UGT2B4(4), UGT2B7(6) 55816845 112 92 110 30 15 10 15 43 29 0 0.426 1.000 1.000 489 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 57 BAK1(1), BFAR(1), CAD(12), CASP10(3), CASP8(1), CSNK1A1(2), DAXX(6), DEDD(2), DFFA(1), DIABLO(1), EGFR(9), EPHB2(2), FAF1(1), FAIM2(1), MAP2K7(1), MAP3K1(7), MAP3K5(5), MAPK10(2), MAPK8IP1(4), MAPK8IP2(1), MAPK8IP3(2), MAPK9(2), NFAT5(8), NFKB1(2), NFKB2(3), NFKBIA(2), NFKBIB(2), NFKBIL1(2), PTPN13(8), RALBP1(2), RIPK1(1), ROCK1(5), SMPD1(4), TPX2(2), TRAF2(1) 69095136 109 92 102 29 17 11 10 43 27 1 0.450 1.000 1.000 490 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 40 ACTR2(2), AKT1(2), AKT2(5), AKT3(3), ARHGAP1(1), ARHGEF11(5), CDC42(1), CFL1(1), CFL2(1), GDI2(2), INPPL1(4), ITPR1(7), ITPR2(12), ITPR3(5), MYLK(4), MYLK2(1), PAK1(3), PAK2(4), PAK3(1), PAK4(3), PAK6(5), PAK7(3), PDK1(1), PIK3CD(2), PIK3CG(4), PIK3R1(5), PITX2(2), PPP1R13B(4), RACGAP1(1), RHO(1), ROCK1(5), ROCK2(3), SAG(5), WASF1(1) 64986210 109 91 108 28 11 21 13 36 28 0 0.232 1.000 1.000 491 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 37 AKT1(2), ATF2(2), CDC42(1), DLD(4), DUSP10(1), DUSP4(1), DUSP8(1), GAB1(2), GCK(2), IL1R1(3), JUN(2), MAP2K5(3), MAP2K7(1), MAP3K1(7), MAP3K10(4), MAP3K11(1), MAP3K12(4), MAP3K13(2), MAP3K2(2), MAP3K3(2), MAP3K4(7), MAP3K5(5), MAP3K7(3), MAP3K9(5), MAPK10(2), MAPK7(4), MAPK9(2), MYEF2(1), NFATC3(7), NR2C2(1), PAPPA(4), SHC1(4), TRAF6(2), ZAK(4) 48939164 98 89 94 27 7 13 12 41 23 2 0.537 1.000 1.000 492 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 36 ANKHD1(13), EEF1A2(3), EEF1B2(3), EEF1D(1), EEF1G(2), EEF2(2), EEF2K(4), EIF1AX(1), EIF2AK1(4), EIF2AK2(4), EIF2AK3(2), EIF2B1(1), EIF2B2(1), EIF2B3(1), EIF2B4(1), EIF2B5(2), EIF2S2(2), EIF2S3(2), EIF4A1(1), EIF4A2(4), EIF4E(2), EIF4EBP1(1), EIF4G1(7), EIF4G3(7), EIF5(3), EIF5A(2), EIF5B(2), ETF1(2), GSPT2(1), PABPC3(17), PAIP1(3), SLC35A4(2) 42628211 103 88 99 33 11 19 16 35 21 1 0.551 1.000 1.000 493 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 44 AKT1(2), AKT2(5), AKT3(3), BRD4(4), CBL(3), CDC42(1), F2RL2(2), FLOT2(1), GRB2(2), GSK3A(2), GSK3B(3), IGFBP1(1), INPPL1(4), IRS1(5), IRS4(1), LNPEP(3), MAPK3(3), PARD3(6), PDK1(1), PIK3CD(2), PIK3R1(5), PTPN1(2), RAF1(4), RPS6KA3(3), RPS6KB1(2), SFN(1), SHC1(4), SLC2A4(2), SORBS1(3), SOS1(8), SOS2(7), YWHAB(1) 52288483 96 86 92 26 10 13 20 29 24 0 0.396 1.000 1.000 494 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 65 APAF1(3), BAD(1), BAK1(1), BCL2L11(1), BID(2), BIRC2(2), BIRC3(5), BIRC5(1), CASP1(3), CASP10(3), CASP2(1), CASP4(3), CASP7(1), CASP8(1), CASP9(2), CHUK(2), DFFA(1), DFFB(1), FAS(2), FASLG(2), HELLS(4), IKBKB(3), IRF2(2), IRF5(3), IRF6(6), IRF7(1), JUN(2), LTA(1), MAP3K1(7), MAPK10(2), MYC(1), NFKB1(2), NFKBIA(2), NFKBIB(2), PLEKHG5(1), PRF1(1), RELA(6), RIPK1(1), TNF(1), TNFRSF10B(1), TNFRSF1A(1), TNFRSF1B(1), TNFRSF21(4), TNFRSF25(1), TP73(4), TRADD(2), TRAF2(1), TRAF3(1) 55175807 102 85 95 29 8 18 16 29 30 1 0.544 1.000 1.000 495 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 64 ACHE(1), AGPAT1(1), CDS2(2), CHAT(5), CHKB(2), CHPT1(3), DGKA(4), DGKB(3), DGKD(3), DGKE(5), DGKG(5), DGKH(6), DGKI(1), DGKQ(3), DGKZ(5), ESCO1(2), ESCO2(1), ETNK1(3), ETNK2(1), GPAM(5), GPD1(1), GPD1L(3), GPD2(1), LCAT(5), LYPLA1(1), PCYT1A(1), PISD(1), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(4), PLD1(2), PLD2(5), PNPLA3(3), PPAP2B(1), PPAP2C(3), PTDSS1(2), SH3GLB1(3) 65536580 102 85 98 30 15 13 9 32 33 0 0.542 1.000 1.000 496 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 40 AGL(7), AMY2A(1), AMY2B(2), ENPP1(4), ENPP3(2), G6PC(3), GAA(3), GBE1(1), GCK(2), GUSB(5), GYS1(3), GYS2(3), HK1(6), MGAM(8), PGM1(1), PYGB(3), PYGL(2), PYGM(4), RNPC3(1), SI(9), UCHL1(1), UCHL3(1), UGDH(1), UGT1A1(5), UGT1A3(1), UGT1A4(2), UGT1A5(2), UGT1A6(3), UGT1A7(3), UGT1A9(5), UGT2B15(1), UGT2B4(4), UXS1(1) 56341088 100 85 99 31 11 10 16 36 27 0 0.692 1.000 1.000 497 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 40 ALAS1(5), ALAS2(5), BLVRA(1), COX10(5), COX15(3), CP(4), EPRS(4), FECH(2), FTMT(5), GUSB(5), HCCS(1), HMOX1(3), MMAB(1), PPOX(2), UGT1A1(5), UGT1A3(1), UGT1A4(2), UGT1A5(2), UGT1A6(3), UGT1A7(3), UGT1A9(5), UGT2A1(3), UGT2A3(3), UGT2B11(2), UGT2B15(1), UGT2B17(1), UGT2B28(5), UGT2B4(4), UGT2B7(6), UROD(2) 41298038 94 84 92 28 10 9 16 38 21 0 0.632 1.000 1.000 498 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 42 CHUK(2), DAXX(6), EGF(5), EGFR(9), ETS1(2), ETS2(1), FOS(1), HOXA7(1), HRAS(1), IKBKB(3), JUN(2), MAP2K3(3), MAP2K7(1), MAP3K1(7), MAP3K5(5), MAPK13(1), MAPK14(1), MAPK3(3), NFKB1(2), NFKBIA(2), PPP2CA(1), PRKCA(2), PRKCD(5), PRKCE(4), PRKCG(6), PRKCH(4), PRKCQ(5), RAF1(4), RELA(6), RIPK1(1), SP1(2), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TRAF2(1) 48453273 102 84 96 25 13 10 4 39 35 1 0.574 1.000 1.000 499 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 29 AKT1(2), AKT2(5), AKT3(3), BCR(1), CD19(1), DAPP1(2), FLOT2(1), GAB1(2), ITPR1(7), ITPR2(12), ITPR3(5), LYN(1), PDK1(1), PHF11(1), PITX2(2), PLCG2(4), PPP1R13B(4), PREX1(8), PTPRC(8), RPS6KA3(3), RPS6KB1(2), SAG(5), SYK(2), TEC(5), VAV1(4) 50477315 91 83 91 25 7 16 14 30 24 0 0.265 1.000 1.000 500 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(1), ACTN1(1), ACTN2(3), BCAR1(6), BCR(1), CAPN1(2), CRKL(1), CSK(4), FYN(2), GRB2(2), HRAS(1), ITGA1(8), ITGB1(7), JUN(2), MAP2K2(1), MAPK3(3), PPP1R12B(2), PTK2(3), PXN(3), RAF1(4), RAP1A(1), ROCK1(5), SHC1(4), SOS1(8), SRC(3), TLN1(13), VCL(2), ZYX(1) 46700891 94 82 93 26 6 13 8 41 25 1 0.600 1.000 1.000 501 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 52 ACAT1(1), ACMSD(2), ALDH1A1(1), ALDH1A2(1), ALDH1B1(4), ALDH2(4), ALDH3A2(2), AOC2(4), AOC3(2), AOX1(8), CAT(2), CYP19A1(2), CYP1A1(1), CYP1A2(4), CYP2A13(5), CYP2A6(4), CYP2A7(2), CYP2B6(1), CYP2C18(1), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP2D6(4), CYP2E1(1), CYP2F1(4), CYP2J2(3), CYP3A5(1), CYP3A7(2), CYP4B1(3), CYP51A1(2), DDC(3), ECHS1(3), EHHADH(6), HAAO(2), HADHA(4), KYNU(3), MAOA(2), MAOB(2), TPH1(2), WARS(1), WARS2(1) 52830338 103 82 102 27 16 14 15 40 18 0 0.198 1.000 1.000 502 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(3), COL4A2(2), COL4A3(7), COL4A4(4), COL4A5(8), COL4A6(7), F10(1), F11(2), F12(7), F2(3), F2R(2), F5(11), F8(8), F9(2), FGA(4), FGB(3), FGG(6), KLKB1(2), PROC(3), PROS1(5), SERPING1(2) 44687494 92 81 90 27 12 15 9 32 23 1 0.382 1.000 1.000 503 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 40 AKT1(2), ASAH1(2), ATF1(2), BRAF(4), CAMP(1), CREB5(3), CREBBP(9), CRKL(1), DAG1(3), EGR2(1), EGR3(2), EGR4(1), ELK1(1), FRS2(2), JUN(2), MAP1B(11), MAP2K7(1), MAPK10(2), MAPK3(3), MAPK8IP1(4), MAPK8IP2(1), MAPK8IP3(2), MAPK9(2), NTRK1(7), PIK3C2G(4), PIK3CD(2), PIK3R1(5), PTPN11(2), RPS6KA3(3), SHC1(4), SRC(3), TH(4) 47522751 96 81 94 29 12 20 10 32 21 1 0.417 1.000 1.000 504 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 35 AKT1(2), AKT2(5), AKT3(3), ARHGEF11(5), CDC42(1), DLG4(2), GNA13(4), LPA(9), MAP3K1(7), MAP3K5(5), NFKB1(2), NFKB2(3), NFKBIA(2), NFKBIB(2), NFKBIL1(2), PDK1(1), PHKA2(5), PI3(1), PIK3CB(5), PLD1(2), PLD2(5), PLD3(3), PTK2(3), RDX(2), ROCK1(5), ROCK2(3), TBXA2R(4) 48951973 93 81 89 29 12 11 11 36 23 0 0.660 1.000 1.000 505 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 44 ADH1A(2), ADH1B(2), ADH4(2), ADH6(2), ADHFE1(3), AGPAT1(1), AKR1A1(2), AKR1B1(3), ALDH1A1(1), ALDH1A2(1), ALDH1B1(4), ALDH2(4), ALDH3A2(2), CEL(3), DGAT1(2), DGKA(4), DGKB(3), DGKD(3), DGKE(5), DGKG(5), DGKH(6), DGKQ(3), DGKZ(5), GK(1), GLA(1), GLB1(5), LCT(7), LIPC(1), LIPF(1), LPL(3), PNLIP(4), PPAP2B(1), PPAP2C(3) 47288821 95 80 94 26 14 13 12 31 25 0 0.278 1.000 1.000 506 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1C4(1), ARSD(2), ARSE(2), CYP11B1(4), CYP11B2(2), CYP19A1(2), HSD11B2(1), HSD17B1(1), HSD17B2(1), HSD17B7(1), HSD17B8(1), HSD3B1(1), LCMT1(1), LCMT2(4), METTL2B(1), PRMT2(2), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(2), PRMT8(3), SRD5A1(1), SULT1E1(2), SULT2A1(1), UGT1A1(5), UGT1A3(1), UGT1A4(2), UGT1A5(2), UGT1A6(3), UGT1A7(3), UGT1A9(5), UGT2A1(3), UGT2A3(3), UGT2B11(2), UGT2B15(1), UGT2B17(1), UGT2B28(5), UGT2B4(4), UGT2B7(6) 49477840 89 80 89 25 6 7 19 29 28 0 0.498 1.000 1.000 507 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 51 ADH1A(2), ADH1B(2), ADH4(2), ADH6(2), ADHFE1(3), AKR1A1(2), ALDH1A1(1), ALDH1A2(1), ALDH1B1(4), ALDH2(4), ALDH3A2(2), ALDH3B1(4), ALDH3B2(3), ALDOA(2), ALDOB(3), ALDOC(1), DLAT(2), DLD(4), ENO1(5), ENO2(1), ENO3(2), G6PC(3), GAPDH(4), GCK(2), HK1(6), LDHB(2), LDHC(3), PDHA1(1), PDHA2(3), PDHB(1), PFKM(3), PFKP(3), PGK1(3), PGM1(1), PKLR(1), TPI1(2) 46395404 90 78 86 27 10 5 15 29 30 1 0.657 1.000 1.000 508 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(1), AGPAT1(1), AGPS(5), CDS2(2), CHAT(5), CHKB(2), CLC(2), DGKA(4), DGKB(3), DGKD(3), DGKE(5), DGKG(5), DGKH(6), DGKQ(3), DGKZ(5), ETNK1(3), GPD1(1), GPD2(1), LCAT(5), LGALS13(1), LYPLA1(1), PAFAH1B1(1), PAFAH2(2), PCYT1A(1), PISD(1), PLA2G4A(2), PLA2G6(4), PLCB2(4), PLCG1(4), PLCG2(4), PPAP2B(1), PPAP2C(3) 49908150 91 78 88 26 15 14 8 27 27 0 0.368 1.000 1.000 509 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 AGXT(2), AGXT2(1), ALAS1(5), ALAS2(5), AOC2(4), AOC3(2), BHMT(7), CHDH(4), CHKB(2), CTH(2), DAO(1), DLD(4), DMGDH(4), GATM(1), GLDC(4), MAOA(2), MAOB(2), PISD(1), PLCB2(4), PLCG1(4), PLCG2(4), SARDH(4), SARS(2), SHMT1(2), SHMT2(5), TARS(5) 41967764 83 78 79 24 9 11 14 23 25 1 0.514 1.000 1.000 510 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 51 ADH1A(2), ADH1B(2), ADH4(2), ADH6(2), ADHFE1(3), AKR1A1(2), ALDH1A1(1), ALDH1A2(1), ALDH1B1(4), ALDH2(4), ALDH3A2(2), ALDH3B1(4), ALDH3B2(3), ALDOA(2), ALDOB(3), ALDOC(1), DLAT(2), DLD(4), ENO1(5), ENO2(1), ENO3(2), G6PC(3), GAPDH(4), GCK(2), HK1(6), LDHB(2), LDHC(3), PDHA1(1), PDHA2(3), PDHB(1), PFKM(3), PFKP(3), PGK1(3), PGM1(1), PKLR(1), TPI1(2) 46395404 90 78 86 27 10 5 15 29 30 1 0.657 1.000 1.000 511 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 42 ALDOA(2), ALDOB(3), ALDOC(1), DLAT(2), DLD(4), ENO1(5), ENO2(1), ENO3(2), G6PC(3), GAPDH(4), GAPDHS(5), GCK(2), GOT1(3), GOT2(2), HK1(6), LDHAL6B(1), LDHB(2), LDHC(3), MDH1(2), MDH2(1), PC(8), PCK1(5), PDHA1(1), PDHA2(3), PDHB(1), PDHX(2), PFKL(3), PFKM(3), PFKP(3), PGAM2(2), PGK1(3), PGK2(1), PKLR(1), TNFAIP1(1), TPI1(2) 40784007 93 78 90 27 6 8 14 23 41 1 0.654 1.000 1.000 512 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 B3GALNT1(1), B3GALT1(1), B3GALT2(2), B3GALT4(1), B3GALT5(3), B3GNT1(2), B3GNT2(3), B3GNT3(1), B3GNT5(1), B4GALNT1(2), B4GALT1(1), B4GALT3(2), B4GALT4(2), B4GALT6(1), FUT2(2), FUT3(2), FUT4(2), FUT6(4), FUT7(1), GBGT1(2), GCNT2(3), PIGB(2), PIGC(1), PIGG(1), PIGK(1), PIGL(2), PIGM(2), PIGN(3), PIGO(5), PIGP(1), PIGQ(4), PIGS(1), PIGT(6), PIGU(1), PIGV(1), PIGZ(3), ST3GAL1(2), ST3GAL3(3), ST3GAL4(2), ST3GAL5(1), ST6GALNAC3(3), ST6GALNAC5(4), ST6GALNAC6(1), ST8SIA1(2), ST8SIA5(1) 47664340 92 77 86 28 12 14 10 29 26 1 0.616 1.000 1.000 513 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 36 CALM2(1), ELK1(1), FCER1G(1), FOS(1), GRB2(2), HRAS(1), JUN(2), LYN(1), MAP2K7(1), MAP3K1(7), MAPK3(3), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), PAK2(4), PIK3R1(5), PLA2G4A(2), PLCG1(4), PPP3CA(3), PPP3CC(3), RAF1(4), SHC1(4), SOS1(8), SYK(2), SYT1(1), VAV1(4) 40063381 87 76 84 29 10 10 9 30 28 0 0.858 1.000 1.000 514 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(3), AARS2(3), CARS(6), CARS2(3), DARS(3), DARS2(1), EPRS(4), FARSA(2), HARS(1), HARS2(1), IARS(4), IARS2(3), LARS(7), LARS2(2), MARS(3), MARS2(4), MTFMT(1), NARS2(6), PARS2(3), QARS(1), RARS(3), RARS2(2), SARS(2), TARS(5), TARS2(7), VARS(4), VARS2(6), WARS(1), WARS2(1), YARS(1), YARS2(1) 53298830 94 76 90 25 3 15 10 40 26 0 0.519 1.000 1.000 515 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 49 ABL1(8), ACTG1(4), ARHGEF2(3), ARPC5L(1), CDC42(1), CDH1(2), CTNNB1(2), EZR(2), FYN(2), HCLS1(1), ITGB1(7), KRT18(1), LY96(1), NCK1(1), NCK2(2), NCL(5), OCLN(3), PRKCA(2), ROCK1(5), ROCK2(3), TLR4(3), TLR5(4), TUBA1A(2), TUBA3C(1), TUBA3D(2), TUBA4A(6), TUBAL3(3), TUBB(3), TUBB1(3), TUBB2B(2), TUBB8(4), WAS(1) 49217257 90 76 89 41 10 19 18 23 20 0 0.970 1.000 1.000 516 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 49 ABL1(8), ACTG1(4), ARHGEF2(3), ARPC5L(1), CDC42(1), CDH1(2), CTNNB1(2), EZR(2), FYN(2), HCLS1(1), ITGB1(7), KRT18(1), LY96(1), NCK1(1), NCK2(2), NCL(5), OCLN(3), PRKCA(2), ROCK1(5), ROCK2(3), TLR4(3), TLR5(4), TUBA1A(2), TUBA3C(1), TUBA3D(2), TUBA4A(6), TUBAL3(3), TUBB(3), TUBB1(3), TUBB2B(2), TUBB8(4), WAS(1) 49217257 90 76 89 41 10 19 18 23 20 0 0.970 1.000 1.000 517 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(1), F11(2), F12(7), F13B(4), F2(3), F5(11), F7(1), F8(8), F9(2), FGA(4), FGB(3), FGG(6), LPA(9), PLAT(4), PLG(8), SERPINB2(1), SERPINF2(2), VWF(15) 34880438 91 75 87 31 9 8 15 30 27 2 0.739 1.000 1.000 518 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 42 AGMAT(2), ALDH1A1(1), ALDH1A2(1), ALDH1B1(4), ALDH2(4), ALDH3A2(2), ALDH4A1(2), AMD1(2), AOC2(4), AOC3(2), ARG1(1), ARG2(1), ASL(4), CKB(1), CKMT1B(1), CPS1(5), DAO(1), GATM(1), GOT1(3), GOT2(2), MAOA(2), MAOB(2), NOS1(10), NOS3(3), OAT(2), ODC1(2), OTC(1), P4HA1(4), P4HA2(1), P4HA3(1), P4HB(3), PYCR1(1), RARS(3), SMS(2) 42884256 81 74 81 23 8 7 17 26 23 0 0.532 1.000 1.000 519 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 41 ACACA(9), ACACB(5), ACAT1(1), ACOT12(1), ACSS1(3), ACSS2(7), AKR1B1(3), ALDH1B1(4), ALDH2(4), ALDH3A2(2), ALDH7A1(1), DLAT(2), DLD(4), GLO1(1), GRHPR(2), HAGH(1), LDHAL6B(1), LDHB(2), LDHC(3), MDH1(2), MDH2(1), ME1(1), ME2(3), ME3(2), PC(8), PCK1(5), PCK2(2), PDHA1(1), PDHA2(3), PDHB(1), PKLR(1) 45475330 86 74 84 22 5 12 18 19 30 2 0.385 1.000 1.000 520 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CALM2(1), CAMK1(3), CAMK1G(3), ELK1(1), FPR1(2), GNA15(1), GNB1(3), HRAS(1), MAP2K2(1), MAP2K3(3), MAP3K1(7), MAPK14(1), MAPK3(3), NCF1(1), NCF2(1), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), NFKB1(2), NFKBIA(2), PAK1(3), PIK3C2G(4), PLCB1(3), PPP3CA(3), PPP3CC(3), RAF1(4), RELA(6), SYT1(1) 38247438 85 73 79 23 11 10 6 26 31 1 0.690 1.000 1.000 521 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR1(2), AGTR2(1), ATP8A1(2), AVPR1A(1), AVPR2(3), BDKRB1(1), BDKRB2(1), BRS3(2), C3AR1(3), CCKAR(4), CCKBR(3), CCR2(2), CCR3(2), CCR5(1), CCR6(1), CCR7(1), CX3CR1(1), CXCR4(1), CXCR6(1), EDNRB(3), FPR1(2), FSHR(2), GALR1(1), GALT(3), GRPR(2), MC1R(2), MC2R(2), MC3R(2), MC4R(1), MC5R(1), NPY1R(1), NPY2R(2), NTSR1(3), OPRD1(3), OPRK1(2), OPRL1(1), OPRM1(3), OXTR(1), SSTR1(3), SSTR2(2), SSTR3(2), SSTR4(3), TACR1(1), TACR2(1), TACR3(2), TRHR(2), TSHR(2) 50346108 88 73 88 29 16 11 13 35 13 0 0.437 1.000 1.000 522 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 AKT1(2), APC(9), ASAH1(2), CAMP(1), CAV3(1), DAG1(3), DLG4(2), EPHB2(2), GNAI1(2), ITPR1(7), ITPR2(12), ITPR3(5), KCNJ3(4), PITX2(2), RHO(1), RYR1(23) 45473864 78 73 78 20 14 11 13 25 15 0 0.189 1.000 1.000 523 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 39 ARNTL(3), BTG1(3), CBX3(1), CLOCK(4), CRY1(1), EIF4G2(4), ETV6(2), GSTP1(2), HERPUD1(3), HSPA8(8), IDI1(1), KLF9(2), MYF6(3), NCKAP1(2), NCOA4(7), NR1D2(2), PER1(5), PER2(6), PPP1R3C(1), PPP2CB(2), PSMA4(2), SF3A3(1), TOB1(5), UGP2(1), ZFR(6) 36283558 77 71 76 28 4 9 15 28 20 1 0.892 1.000 1.000 524 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 41 CDC6(2), CDC7(2), CDK2(2), CDT1(2), DIAPH2(2), MCM10(4), MCM2(10), MCM3(1), MCM4(1), MCM5(3), MCM6(5), MCM7(6), PCNA(3), POLD1(7), POLD3(1), POLE(5), POLE2(1), PRIM1(3), RFC1(5), RFC2(1), RFC4(2), RFC5(3), RPA1(2), RPA2(1), RPA3(1), RPA4(2), RPS27A(1), UBA52(1), UBB(1), UBC(4) 46885015 84 71 81 23 10 8 10 32 24 0 0.530 1.000 1.000 525 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 32 ACTA1(1), CRKL(1), DOCK1(3), ELK1(1), FOS(1), GAB1(2), GRB2(2), HGF(1), HRAS(1), ITGA1(8), ITGB1(7), JUN(2), MAP2K2(1), MAP4K1(4), MAPK3(3), PAK1(3), PIK3R1(5), PTK2(3), PTK2B(3), PTPN11(2), PXN(3), RAF1(4), RAP1A(1), RASA1(7), SOS1(8), SRC(3), STAT3(3) 39125202 83 71 82 23 4 17 8 29 25 0 0.645 1.000 1.000 526 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 20 ATM(19), ATR(12), BRCA1(7), BRCA2(12), CHEK1(1), CHEK2(2), FANCA(5), FANCD2(1), FANCE(2), FANCF(2), FANCG(4), HUS1(2), MRE11A(3), RAD17(2), RAD50(4), RAD51(2), TREX1(3) 43535384 83 70 82 20 6 14 11 34 18 0 0.350 1.000 1.000 527 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BLNK(1), CALM2(1), ELK1(1), FOS(1), GRB2(2), HRAS(1), JUN(2), LYN(1), MAP3K1(7), MAPK14(1), MAPK3(3), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), PLCG1(4), PPP3CA(3), PPP3CC(3), PRKCA(2), RAF1(4), SHC1(4), SOS1(8), SYK(2), SYT1(1), VAV1(4) 37521064 78 69 75 25 9 10 9 24 26 0 0.810 1.000 1.000 528 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(7), CREBBP(9), EP300(16), ERCC3(4), GRIP1(3), GTF2A1(2), GTF2E1(1), GTF2F1(1), HDAC1(2), HDAC4(1), HDAC5(3), HDAC6(3), NCOR2(6), NRIP1(5), PELP1(1), POLR2A(13), TBP(1) 46262931 78 69 74 45 6 9 12 26 25 0 1.000 1.000 1.000 529 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 33 ACTG1(4), ACTG2(1), ACTR2(2), AKT1(2), CDC42(1), CFL1(1), CFL2(1), FLNA(6), FLNC(10), FSCN1(4), FSCN2(1), FSCN3(2), GDI2(2), MYH2(9), MYLK(4), MYLK2(1), PAK1(3), PAK2(4), PAK3(1), PAK4(3), PAK6(5), PAK7(3), RHO(1), ROCK1(5), ROCK2(3), WASF1(1) 44641749 80 68 80 28 7 15 4 25 29 0 0.817 1.000 1.000 530 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 ARHGDIB(1), CASP10(3), CASP7(1), CASP8(1), CFLAR(1), DAXX(6), DFFA(1), DFFB(1), FAF1(1), JUN(2), LMNB1(3), LMNB2(1), MAP3K1(7), MAP3K7(3), PAK1(3), PAK2(4), PRKDC(12), PTPN13(8), RB1(4), RIPK2(4), SPTAN1(12) 42361490 79 67 79 24 6 7 11 25 27 3 0.724 1.000 1.000 531 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 B3GNT6(4), B4GALT5(2), GALNT1(1), GALNT10(7), GALNT11(3), GALNT13(3), GALNT14(3), GALNT2(2), GALNT4(3), GALNT5(6), GALNT6(5), GALNT7(7), GALNT8(1), GALNT9(1), GALNTL5(3), GCNT1(2), GCNT3(2), GCNT4(3), OGT(5), ST3GAL1(2), ST6GALNAC1(2), WBSCR17(5) 32403597 72 67 68 27 5 7 15 25 20 0 0.900 1.000 1.000 532 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 AKR1C3(2), ALOX12(3), ALOX12B(2), ALOX15B(3), ALOX5(4), CBR1(4), CYP2B6(1), CYP2C18(1), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP2E1(1), CYP2J2(3), CYP2U1(1), CYP4A11(5), CYP4A22(1), CYP4F2(4), CYP4F3(2), DHRS4(3), EPHX2(1), GGT1(4), GPX6(1), LTA4H(4), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(4), PTGDS(1), PTGS1(2), PTGS2(5), TBXAS1(4) 38801290 74 67 72 20 8 8 17 22 18 1 0.336 1.000 1.000 533 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(2), CALM2(1), ELK1(1), FOS(1), GNAI1(2), GNAS(6), GNB1(3), HRAS(1), JUN(2), MAPK3(3), NFATC1(4), NFATC2(8), NFATC3(7), NFATC4(3), PLCG1(4), PPP3CA(3), PPP3CC(3), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PRKCA(2), RAF1(4), RPS6KA3(3), SYT1(1) 33890354 74 66 71 22 11 8 6 26 23 0 0.709 1.000 1.000 534 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(2), ARG1(1), ARG2(1), ASL(4), ASS1(3), CKB(1), CKMT1B(1), CPS1(5), DAO(1), EPRS(4), GATM(1), GLUD2(7), GOT1(3), GOT2(2), LAP3(4), NOS1(10), NOS3(3), OAT(2), OTC(1), P4HA1(4), P4HA2(1), P4HA3(1), PARS2(3), PRODH(3), PYCR1(1), PYCR2(1), RARS(3), RARS2(2) 35757050 75 66 73 21 8 6 16 28 17 0 0.503 1.000 1.000 535 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 33 AKT1(2), BAD(1), CBL(3), CFLAR(1), CRKL(1), E2F1(1), FOS(1), GRB2(2), HRAS(1), IL2RA(2), IL2RB(2), IRS1(5), JAK1(6), JAK3(4), MAPK3(3), MYC(1), PIK3R1(5), PPIA(1), PTPN6(3), RAF1(4), RPS6KB1(2), SHC1(4), SOCS3(1), SOS1(8), STAT5A(3), STAT5B(3), SYK(2) 33198415 72 66 71 21 9 11 12 19 21 0 0.525 1.000 1.000 536 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(7), AR(5), ESR2(4), ESRRA(1), HNF4A(2), NR1D2(2), NR1H3(2), NR1I2(1), NR1I3(1), NR2C2(1), NR2E1(1), NR2F1(1), NR2F2(4), NR2F6(1), NR3C1(4), NR4A1(1), NR4A2(1), NR5A1(1), NR5A2(2), PGR(5), PPARD(1), PPARG(2), RARA(4), RARB(2), RARG(1), RORA(2), RORC(2), RXRB(4), RXRG(2), THRA(1), VDR(2) 40701245 70 66 69 25 10 10 13 25 12 0 0.720 1.000 1.000 537 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(3), BAD(1), BCL2A1(2), CASP1(3), CASP10(3), CASP2(1), CASP4(3), CASP7(1), CASP8(1), CASP9(2), CD40(1), DAXX(6), DFFA(1), DFFB(1), FAS(2), FASLG(2), IKBKE(3), LTA(1), NFKB1(2), NFKBIA(2), NGFR(1), NR3C1(4), NTRK1(7), PTPN13(8), RIPK1(1), TFG(2), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TRADD(2), TRAF2(1), TRAF3(1), TRAF6(2) 43389187 73 65 72 18 4 14 12 29 14 0 0.281 1.000 1.000 538 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 37 CCNH(1), ERCC3(4), GTF2B(2), GTF2E1(1), GTF2E2(3), GTF2F2(1), GTF2H1(2), GTF2H2(1), GTF2H4(1), ILK(4), MNAT1(1), POLR1A(6), POLR1B(4), POLR2A(13), POLR2B(7), POLR2F(4), POLR2I(1), POLR2J(1), POLR3B(5), POLR3H(1), POLR3K(1), TAF5(2), TAF6(2), TAF7(2), TBP(1) 35228221 71 65 66 21 5 7 8 24 27 0 0.702 1.000 1.000 539 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 23 ARNT(2), EIF1(2), EIF2B1(1), EIF2B2(1), EIF2B3(1), EIF2B4(1), EIF2B5(2), EIF2S2(2), EIF2S3(2), FLT1(8), FLT4(14), HIF1A(4), HRAS(1), KDR(6), NOS3(3), PIK3R1(5), PLCG1(4), PRKCA(2), PTK2(3), PXN(3), SHC1(4) 31583049 71 63 70 24 10 7 9 21 23 1 0.842 1.000 1.000 540 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 31 ACTR2(2), AKT1(2), DAG1(3), DGKA(4), GCA(3), ITGA9(3), ITPKA(1), ITPKB(3), ITPR1(7), ITPR2(12), ITPR3(5), MAPK3(3), NR1I3(1), PAK1(3), PDE3A(3), PDE3B(3), PI3(1), PIK3C2G(4), PIK3CD(2), PIK3R1(5) 46768437 70 62 70 22 8 12 8 26 16 0 0.594 1.000 1.000 541 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 ARHGDIB(1), BAG4(1), CASP2(1), CASP8(1), DFFA(1), DFFB(1), JUN(2), LMNB1(3), LMNB2(1), MADD(8), MAP3K1(7), MAP3K7(3), PAK1(3), PAK2(4), PRKDC(12), RB1(4), RIPK1(1), SPTAN1(12), TNF(1), TNFRSF1A(1), TRADD(2), TRAF2(1) 39344213 71 62 71 24 3 8 12 20 25 3 0.830 1.000 1.000 542 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 22 IMPA1(1), INPP4A(2), INPP4B(4), INPP5A(1), INPPL1(4), ITPKA(1), ITPKB(3), MIOX(2), OCRL(3), PIK3C2A(6), PIK3C2B(5), PIK3C2G(4), PIK3CB(5), PIK3CG(4), PLCB1(3), PLCB2(4), PLCB3(3), PLCB4(5), PLCD1(3), PLCG1(4), PLCG2(4) 42879605 71 61 70 23 5 7 5 30 24 0 0.902 1.000 1.000 543 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(3), AKR1B10(2), B4GALT1(1), G6PC(3), GAA(3), GALK1(1), GALK2(2), GALT(3), GANC(3), GCK(2), GLA(1), GLB1(5), HK1(6), LALBA(1), LCT(7), MGAM(8), PFKL(3), PFKM(3), PFKP(3), PGM1(1), RDH11(4), RDH13(1), UGP2(1) 38163708 67 60 66 25 9 8 8 22 20 0 0.889 1.000 1.000 544 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(4), ACTG2(1), ADCY3(6), ADCY9(7), ARF1(1), ARF3(3), ARF5(1), ARF6(1), ARL4D(1), ATP6V0A1(3), ATP6V0A2(2), ATP6V0A4(4), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(4), ATP6V1D(1), ATP6V1G1(1), GNAS(6), PDIA4(1), PLCG1(4), PLCG2(4), PRKCA(2), SEC61B(2), TRIM23(5) 36995340 67 60 65 23 5 6 9 29 18 0 0.878 1.000 1.000 545 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 18 ABL1(8), ATM(19), BRCA1(7), CDKN1A(3), CHEK1(1), CHEK2(2), JUN(2), MRE11A(3), NFKB1(2), NFKBIA(2), RAD50(4), RAD51(2), RBBP8(2), RELA(6), TP73(4) 28706811 67 59 63 20 7 9 6 25 18 2 0.753 1.000 1.000 546 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 39 AKR1B1(3), AKR1B10(2), ALDOA(2), ALDOB(3), ALDOC(1), FPGT(1), FUK(2), GMDS(2), GMPPA(2), GMPPB(2), HK1(6), KHK(6), MPI(1), MTMR1(2), MTMR2(3), MTMR6(1), PFKFB3(4), PFKFB4(1), PFKL(3), PFKM(3), PFKP(3), PGM2(2), PHPT1(1), PMM1(1), RDH11(4), RDH13(1), TPI1(2) 36558842 64 59 64 20 9 7 12 19 17 0 0.616 1.000 1.000 547 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 ATF2(2), CDC42(1), DAXX(6), ELK1(1), GRB2(2), HRAS(1), HSPB2(2), MAP3K1(7), MAP3K5(5), MAP3K7(3), MAP3K9(5), MAPK14(1), MAPKAPK2(1), MAX(5), MEF2A(2), MEF2D(1), MKNK1(2), MYC(1), PLA2G4A(2), RIPK1(1), RPS6KA5(2), SHC1(4), STAT1(5), TGFB2(2), TGFBR1(1), TRADD(2), TRAF2(1) 36779176 68 59 66 18 8 6 4 31 18 1 0.619 1.000 1.000 548 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSA(2), ARSD(2), ARSE(2), ASAH1(2), B4GALT6(1), CERK(6), DEGS1(2), DEGS2(1), ENPP7(2), GAL3ST1(4), GALC(3), GBA(3), GLA(1), GLB1(5), LCT(7), NEU1(1), PPAP2B(1), PPAP2C(3), SGMS1(1), SGPP1(2), SMPD1(4), SMPD2(3), SMPD4(2), SPHK1(1), SPHK2(1), SPTLC1(1), SPTLC2(2), UGT8(1) 34445146 66 56 62 24 11 12 6 21 16 0 0.752 1.000 1.000 549 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 MRPL13(1), MRPS7(1), RPL10A(2), RPL11(3), RPL13(1), RPL14(1), RPL18(3), RPL18A(2), RPL19(2), RPL21(1), RPL22L1(1), RPL24(1), RPL26(1), RPL27(1), RPL28(1), RPL3(3), RPL30(3), RPL31(1), RPL32(1), RPL34(1), RPL36AL(1), RPL38(1), RPL3L(3), RPL6(1), RPL7(1), RPL8(1), RPS11(1), RPS13(1), RPS2(2), RPS21(2), RPS24(2), RPS26(1), RPS27(1), RPS29(1), RPS3(2), RPS3A(1), RPS4Y1(1), RPS7(1), RPS8(1), RPS9(1), RPSA(1) 22043805 58 56 58 16 5 6 9 23 14 1 0.606 1.000 1.000 550 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(6), CALM2(1), CRKL(1), GRB2(2), HRAS(1), JUN(2), MAP2K2(1), MAP2K3(3), MAP3K1(7), MAPK14(1), MAPK3(3), PAK1(3), PLCG1(4), PRKCA(2), PTK2B(3), RAF1(4), SHC1(4), SOS1(8), SRC(3), SYT1(1) 28336172 60 55 59 20 4 11 4 24 16 1 0.882 1.000 1.000 551 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(1), ACTN1(1), ACTN2(3), CAPN1(2), ITGA1(8), ITGB1(7), ITGB3(3), PTK2(3), PXN(3), SPTAN1(12), SRC(3), TLN1(13) 28528464 59 55 58 20 3 8 5 23 20 0 0.857 1.000 1.000 552 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 28 AKT1(2), CABIN1(11), CALM2(1), CAMK1(3), CAMK1G(3), HDAC5(3), IGF1R(3), INS(1), MAPK14(1), MAPK7(4), MEF2A(2), MEF2D(1), NFATC1(4), NFATC2(8), PIK3R1(5), PPP3CA(3), PPP3CC(3), SYT1(1) 29222876 59 53 55 18 11 6 3 22 17 0 0.642 1.000 1.000 553 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 22 GHR(1), GRB2(2), HRAS(1), INS(1), IRS1(5), JAK2(7), MAPK3(3), PIK3R1(5), PLCG1(4), PRKCA(2), PTPN6(3), RAF1(4), SHC1(4), SLC2A4(2), SOS1(8), STAT5A(3), STAT5B(3) 26298599 58 52 56 19 6 7 9 21 15 0 0.798 1.000 1.000 554 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 25 AKT1(2), APC(9), AXIN1(4), CTNNB1(2), DVL1(1), FZD1(3), GNAI1(2), GSK3B(3), IRAK1(3), LBP(1), LEF1(3), LY96(1), NFKB1(2), PIK3R1(5), PPP2CA(1), RELA(6), TLR4(3), WNT1(2) 27878814 53 51 48 16 4 7 5 19 17 1 0.719 1.000 1.000 555 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(2), ATF1(2), CDC42(1), CREB5(3), DUSP10(1), EEF2K(4), EIF4E(2), ELK1(1), IL1R1(3), MAP2K3(3), MAP3K10(4), MAP3K4(7), MAP3K5(5), MAP3K7(3), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPKAPK2(1), MKNK1(2), MKNK2(1), MYEF2(1), NFKB1(2), NR2C2(1), TRAF6(2) 33387178 55 51 55 16 4 12 3 26 9 1 0.474 1.000 1.000 556 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 40 APAF1(3), BAK1(1), BID(2), BIRC2(2), BIRC3(5), CASP2(1), CASP7(1), CASP8(1), CASP9(2), FAS(2), FASLG(2), JUN(2), MAP3K1(7), MAPK10(2), MYC(1), NFKB1(2), NFKBIA(2), PARP1(5), PRF1(1), RELA(6), RIPK1(1), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TRADD(2), TRAF2(1) 35681958 57 50 54 21 2 13 9 15 17 1 0.864 1.000 1.000 557 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(3), F2R(2), F2RL3(1), GNAI1(2), GNB1(3), HRAS(1), ITGA1(8), ITGB1(7), MAPK3(3), PLA2G4A(2), PLCB1(3), PRKCA(2), PTGS1(2), PTK2(3), RAF1(4), SRC(3), SYK(2), TBXAS1(4) 24358796 55 50 54 19 5 7 8 16 18 1 0.823 1.000 1.000 558 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 32 CHUK(2), ELK1(1), FOS(1), IKBKB(3), IRAK1(3), JUN(2), LY96(1), MAP2K3(3), MAP3K1(7), MAP3K7(3), MAPK14(1), NFKB1(2), NFKBIA(2), RELA(6), TLR10(3), TLR2(2), TLR3(1), TLR4(3), TLR6(2), TLR7(5), TLR9(1), TRAF6(2) 36225584 56 50 52 15 5 9 3 21 16 2 0.545 1.000 1.000 559 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 19 AKT1(2), APAF1(3), ATM(19), BAD(1), BID(2), CASP7(1), CASP9(2), PRKCA(2), PTK2(3), PXN(3), STAT1(5), TLN1(13) 26635246 56 49 55 16 5 7 6 19 19 0 0.588 1.000 1.000 560 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(3), B4GALT1(1), G6PC(3), GAA(3), GALK1(1), GALK2(2), GALT(3), GCK(2), GLA(1), GLB1(5), HK1(6), LALBA(1), LCT(7), MGAM(8), PFKM(3), PFKP(3), PGM1(1) 32229810 53 49 52 22 7 6 5 16 19 0 0.963 1.000 1.000 561 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(11), CALM2(1), CAPN2(4), EP300(16), HDAC1(2), MEF2D(1), NFATC1(4), NFATC2(8), PPP3CA(3), PPP3CC(3), PRKCA(2), SYT1(1) 23801443 56 49 51 19 8 4 4 21 19 0 0.884 1.000 1.000 562 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 23 ATF2(2), BCR(1), BLNK(1), ELK1(1), FOS(1), GRB2(2), HRAS(1), JUN(2), LYN(1), MAP3K1(7), MAPK3(3), MAPK8IP3(2), PAPPA(4), RPS6KA3(3), SHC1(4), SOS1(8), SYK(2), VAV1(4), VAV2(4), VAV3(1) 30115663 54 49 54 16 5 11 7 19 12 0 0.474 1.000 1.000 563 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 31 APAF1(3), BID(2), BIRC2(2), BIRC3(5), CASP10(3), CASP7(1), CASP8(1), CASP9(2), CFLAR(1), CHUK(2), DFFA(1), DFFB(1), GAS2(3), NFKB1(2), NFKBIA(2), RELA(6), RIPK1(1), SPTAN1(12), TNFRSF10B(1), TNFRSF25(1), TRADD(2), TRAF2(1) 32754440 55 48 52 16 2 8 9 17 18 1 0.625 1.000 1.000 564 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 19 AKT1(2), EIF4A1(1), EIF4A2(4), EIF4E(2), EIF4EBP1(1), EIF4G1(7), EIF4G2(4), EIF4G3(7), GHR(1), IRS1(5), MAPK14(1), MAPK3(3), MKNK1(2), PDK2(3), PIK3R1(5), PRKCA(2), RPS6KB1(2) 23636160 52 48 52 16 6 9 6 20 11 0 0.618 1.000 1.000 565 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(4), GTF2A1(2), GTF2B(2), GTF2E1(1), GTF2F1(1), NCOA1(3), NCOA2(11), NCOA3(9), NCOR2(6), POLR2A(13), RARA(4), TBP(1) 24972585 57 48 50 28 5 6 7 15 24 0 0.983 1.000 1.000 566 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 24 ADCY1(2), AKT1(2), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), GNAS(6), GRB2(2), HRAS(1), MAPK14(1), MAPK3(3), PIK3R1(5), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PRKCA(2), RPS6KA5(2), SOS1(8) 25240236 49 47 49 15 6 8 3 22 10 0 0.654 1.000 1.000 567 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM2(1), DLG4(2), GRIN1(2), GRIN2A(8), GRIN2B(8), GRIN2D(2), NOS1(10), PPP3CA(3), PPP3CC(3), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), PRKCA(2), SYT1(1) 25363665 52 47 51 19 10 8 4 21 9 0 0.707 1.000 1.000 568 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 25 BLVRA(1), CP(4), EPRS(4), FECH(2), GUSB(5), HCCS(1), HMOX1(3), PPOX(2), UGT1A1(5), UGT1A3(1), UGT1A4(2), UGT1A5(2), UGT1A6(3), UGT1A7(3), UGT1A9(5), UGT2B15(1), UGT2B4(4), UROD(2) 26672544 50 47 50 15 5 5 11 17 12 0 0.558 1.000 1.000 569 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 21 DLG4(2), EPHB2(2), F2(3), F2RL1(1), F2RL2(2), F2RL3(1), JUN(2), MAP2K5(3), MAPK7(4), MYEF2(1), PLD1(2), PLD2(5), PLD3(3), PTK2(3), RAF1(4), SRC(3), TEC(5), VAV1(4) 25929953 50 47 47 16 6 5 6 22 11 0 0.733 1.000 1.000 570 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CREBBP(9), EP300(16), NCOA3(9), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3), RARA(4) 20453810 48 46 45 17 3 3 8 17 17 0 0.748 1.000 1.000 571 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 21 ADCY1(2), AKT1(2), ASAH1(2), GNAI1(2), GNB1(3), ITGAV(1), ITGB3(3), MAPK3(3), PDGFRA(6), PIK3R1(5), PLCB1(3), PRKCA(2), PTK2(3), SMPD1(4), SMPD2(3), SPHK1(1), SRC(3) 25133053 48 46 47 21 7 9 4 16 12 0 0.948 1.000 1.000 572 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 22 BCAR1(6), CXCR4(1), GNAI1(2), GNB1(3), HRAS(1), MAPK3(3), NFKB1(2), PIK3C2G(4), PIK3R1(5), PLCG1(4), PRKCA(2), PTK2(3), PTK2B(3), PXN(3), RAF1(4), RELA(6) 25800150 52 45 48 23 3 8 5 19 15 2 0.990 1.000 1.000 573 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 32 GORASP1(1), MAP2K7(1), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(3), MAPK8IP1(4), MAPK8IP2(1), MAPK8IP3(2), MAPK9(2), NFKB1(2), NFKB2(3), NFKBIA(2), NFKBIB(2), NFKBIL1(2), PIK3CD(2), PIK3R1(5), SYT1(1), TRAF2(1), TRAF3(1), TRAF5(5), TRAF6(2) 30930118 48 45 48 13 10 6 4 20 8 0 0.392 1.000 1.000 574 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 13 BAIAP2(2), CASP1(3), CASP7(1), CASP8(1), GAPDH(4), INS(1), ITCH(1), MAGI1(4), MAGI2(6), RERE(11), WWP1(8), WWP2(4) 18937442 46 44 43 17 9 2 5 19 11 0 0.933 1.000 1.000 575 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(3), CARS(6), DARS(3), EPRS(4), HARS(1), IARS(4), LARS(7), LARS2(2), MARS(3), MARS2(4), QARS(1), RARS(3), SARS(2), TARS(5), WARS(1), WARS2(1), YARS(1) 32235504 51 43 48 13 1 5 7 21 17 0 0.615 1.000 1.000 576 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 20 CCR3(2), CFL1(1), GNAS(6), GNB1(3), HRAS(1), MAPK3(3), MYL2(1), NOX1(7), PIK3C2G(4), PLCB1(3), PPP1R12B(2), PRKCA(2), PTK2(3), RAF1(4), ROCK2(3) 24333289 45 43 43 13 3 5 7 18 12 0 0.750 1.000 1.000 577 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 31 ADRA1A(4), ADRB2(2), CHRM1(2), CHRM2(6), CHRM3(3), CHRM5(2), DRD1(1), DRD2(1), DRD3(3), DRD5(4), HRH2(1), HTR1A(2), HTR1B(1), HTR1D(2), HTR1E(3), HTR1F(2), HTR2A(1), HTR2B(1), HTR2C(1), HTR4(2), HTR6(2), HTR7(2) 24622013 48 43 46 25 8 4 3 23 10 0 0.971 1.000 1.000 578 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSA(2), ARSB(1), ARSD(2), ARSE(2), ASAH1(2), GAL3ST1(4), GALC(3), GBA(3), GLA(1), GLB1(5), LCT(7), NEU1(1), PPAP2B(1), PPAP2C(3), SMPD1(4), SMPD2(3), SPTLC1(1), SPTLC2(2) 23445985 47 42 46 17 8 7 4 17 11 0 0.752 1.000 1.000 579 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(2), AP2A1(3), AP2M1(1), ARF1(1), BAD(1), EEA1(7), GSK3A(2), GSK3B(3), LYN(1), PFKL(3), PFKM(3), PFKP(3), PLCG1(4), PRKCE(4), PRKCZ(1), RAB5A(1), RPS6KB1(2), VAV2(4) 25044969 46 42 43 16 3 6 9 15 13 0 0.834 1.000 1.000 580 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 24 AKR1B1(3), ALDOA(2), ALDOB(3), ALDOC(1), FPGT(1), GCK(2), GMDS(2), GMPPA(2), GMPPB(2), HK1(6), KHK(6), MPI(1), PFKFB3(4), PFKFB4(1), PFKM(3), PFKP(3), PMM1(1), TPI1(2) 23303734 45 41 45 18 5 3 9 12 16 0 0.938 1.000 1.000 581 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 18 ADCY1(2), ARHGEF1(2), F2(3), F2R(2), F2RL3(1), GNA12(1), GNA13(4), GNAI1(2), GNB1(3), MAP3K7(3), PIK3R1(5), PLCB1(3), PPP1R12B(2), PRKCA(2), PTK2B(3), ROCK1(5) 23428080 43 40 43 13 8 5 3 16 10 1 0.600 1.000 1.000 582 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA1(1), ANXA3(3), ANXA4(4), ANXA6(3), CYP11A1(2), EDNRB(3), HPGD(1), HSD11B2(1), PLA2G4A(2), PTGDR(1), PTGDS(1), PTGER2(1), PTGER4(1), PTGFR(5), PTGIR(2), PTGS1(2), PTGS2(5), TBXAS1(4) 20337800 42 40 42 18 5 4 7 15 10 1 0.899 1.000 1.000 583 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(1), ACTN2(3), BCAR1(6), CSK(4), CTNNA1(7), CTNNA2(7), CTNNB1(2), PTK2(3), PXN(3), SRC(3), VCL(2) 19060330 41 39 41 17 5 5 6 16 8 1 0.900 1.000 1.000 584 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1R(6), DDX20(7), E2F1(1), ETS1(2), ETS2(1), FOS(1), HDAC5(3), HRAS(1), JUN(2), NCOR2(6), RBL2(5), SIN3A(4), SIN3B(3) 26135928 42 39 42 13 7 4 3 15 13 0 0.653 1.000 1.000 585 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 23 ASNS(2), CA1(1), CA13(2), CA14(3), CA5B(1), CA6(1), CA7(1), CA9(2), CPS1(5), CTH(2), GLS(6), GLS2(4), GLUD2(7), GLUL(2), HAL(1) 20492192 40 39 38 14 2 5 6 23 4 0 0.808 1.000 1.000 586 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(9), APOA1(1), CETP(1), DGAT1(2), LCAT(5), LDLR(3), LIPC(1), LPL(3), LRP1(12), SCARB1(2), SOAT1(4) 26955573 43 39 41 13 4 7 4 15 13 0 0.550 1.000 1.000 587 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(1), GALNT10(7), GALNT2(2), GALNT4(3), GALNT6(5), GALNT7(7), GALNT8(1), GALNT9(1), GCNT1(2), ST3GAL1(2), ST3GAL4(2), WBSCR17(5) 14590676 38 37 35 22 2 2 7 12 15 0 0.998 1.000 1.000 588 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 28 BAG4(1), BIRC2(2), BIRC3(5), CASP8(1), CFLAR(1), JUN(2), MAP3K3(2), MAP3K7(3), NFKB1(2), NFKB2(3), NFKBIA(2), NFKBIB(2), NFKBIL1(2), NR2C2(1), RALBP1(2), RIPK1(1), TNF(1), TNFAIP3(2), TNFRSF1A(1), TNFRSF1B(1), TRADD(2), TRAF2(1) 26674377 40 37 40 13 4 8 6 16 5 1 0.522 1.000 1.000 589 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 25 ATF1(2), CASP2(1), CHUK(2), IKBKB(3), JUN(2), LTA(1), MAP2K3(3), MAP3K1(7), MAPK14(1), NFKB1(2), NFKBIA(2), RELA(6), RIPK1(1), TANK(1), TNF(1), TNFRSF1A(1), TRADD(2), TRAF2(1) 24269862 39 36 36 12 3 5 2 15 13 1 0.865 1.000 1.000 590 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 11 ARF1(1), ARFGAP1(1), ARFGAP3(2), ARFGEF2(8), CLTA(1), CLTB(2), COPA(7), GBF1(12), GPLD1(2) 15853316 36 35 36 12 1 2 2 18 12 1 0.901 1.000 1.000 591 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(2), ALOX5(4), CYP1A2(4), CYP2C18(1), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP2E1(1), CYP2J2(3), CYP3A43(2), CYP3A5(1), CYP3A7(2), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(4), RDH11(4), RDH13(1) 23945609 37 35 37 16 5 3 4 16 9 0 0.863 1.000 1.000 592 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT1(1), AGPS(5), CHPT1(3), ENPP2(3), ENPP6(1), PAFAH1B1(1), PAFAH1B2(1), PAFAH2(2), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(4), PLD1(2), PLD2(5), PPAP2B(1), PPAP2C(3) 23345073 37 34 35 18 7 4 3 15 8 0 0.953 1.000 1.000 593 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 14 AKT1(2), BAD(1), GRB2(2), HRAS(1), IGF1R(3), IRS1(5), MAPK3(3), PIK3R1(5), RAF1(4), SHC1(4), SOS1(8) 16298899 38 34 38 12 7 6 4 14 7 0 0.557 1.000 1.000 594 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 11 AKT1(2), DPM2(1), GRB2(2), HRAS(1), NTRK1(7), PIK3R1(5), PLCG1(4), PRKCA(2), SHC1(4), SOS1(8) 13238470 36 34 34 13 2 7 2 15 10 0 0.857 1.000 1.000 595 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(1), COASY(2), DPYD(5), DPYS(4), ENPP1(4), ENPP3(2), ILVBL(3), PANK1(2), PANK2(5), PANK3(3), PANK4(1), PPCS(1), UPB1(1), VNN1(1) 17126387 35 33 35 12 3 3 4 14 11 0 0.804 1.000 1.000 596 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CCR5(1), CD3E(1), CD3G(2), ETV5(3), IL12RB1(4), IL12RB2(2), IL18R1(1), JAK2(7), JUN(2), MAPK14(1), STAT4(2), TYK2(7) 18708322 33 33 32 11 3 1 6 15 8 0 0.861 1.000 1.000 597 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 15 AKT1(2), GRB2(2), HRAS(1), MAPK3(3), MAPK7(4), MEF2A(2), MEF2D(1), NTRK1(7), PIK3R1(5), PLCG1(4), SHC1(4) 15350205 35 32 32 12 4 4 3 17 7 0 0.802 1.000 1.000 598 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 21 ADCY1(2), AKT1(2), BAD(1), CSF2RB(5), IGF1R(3), IL3(1), KITLG(2), PIK3R1(5), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3) 19485402 31 30 31 15 8 2 1 13 7 0 0.903 1.000 1.000 599 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 ASNS(2), CA1(1), CA14(3), CA5B(1), CA6(1), CA7(1), CA9(2), CPS1(5), CTH(2), GLS(6), GLS2(4), GLUL(2), HAL(1) 18914320 31 30 31 10 1 4 4 18 4 0 0.759 1.000 1.000 600 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(6), JAK2(7), JAK3(4), MAPK3(3), STAT3(3), TYK2(7) 11689003 30 30 29 10 2 0 8 11 9 0 0.864 1.000 1.000 601 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(3), ARHGDIB(1), BIRC2(2), BIRC3(5), CASP1(3), CASP10(3), CASP2(1), CASP4(3), CASP7(1), CASP8(1), CASP9(2), DFFA(1), DFFB(1), LMNB1(3), LMNB2(1), PRF1(1) 19078382 32 29 32 12 0 8 6 10 8 0 0.801 1.000 1.000 602 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(5), EGFR(9), MAP3K1(7), MAPK14(1), NCOR2(6), RARA(4), THRA(1) 17113989 33 29 31 11 2 5 5 9 12 0 0.838 1.000 1.000 603 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(1), PSMA3(2), PSMA4(2), PSMA6(3), PSMA7(1), PSMB1(2), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(1), PSMC2(1), PSMD1(2), PSMD11(4), PSMD12(1), PSMD13(2), PSMD2(5), PSMD6(2) 16157887 32 29 31 11 3 3 4 8 14 0 0.850 1.000 1.000 604 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(3), CLOCK(4), CRY1(1), CSNK1E(3), NPAS2(1), PER1(5), PER2(6), PER3(6) 16900305 29 29 27 13 4 2 7 9 7 0 0.916 1.000 1.000 605 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(9), EP300(16), MAPK3(3), PELP1(1), SRC(3) 14702121 32 29 29 15 2 4 6 9 11 0 0.936 1.000 1.000 606 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 12 ARNT(2), COPS5(1), EP300(16), HIF1A(4), JUN(2), NOS3(3), P4HB(3) 16599924 31 28 28 11 1 0 3 11 15 1 0.924 1.000 1.000 607 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 DRD1(1), DRD2(1), GRM1(4), PLCB1(3), PPP1CA(1), PPP1R1B(1), PPP2CA(1), PPP3CA(3), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2A(1), PRKAR2B(3) 15890797 25 25 25 13 4 0 0 10 11 0 0.959 1.000 1.000 608 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 GOSR1(1), SNAP23(1), SNAP29(1), STX10(1), STX11(2), STX16(1), STX17(1), STX18(1), STX19(1), STX2(2), STX4(2), STX5(1), STX7(1), STX8(1), TSNARE1(3), USE1(1), VAMP1(1), VAMP2(1), VTI1A(1) 16806685 24 24 24 11 4 4 3 9 4 0 0.801 1.000 1.000 609 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAS1(5), ALAS2(5), CPO(1), FECH(2), GATA1(4), HBB(3), UROD(2) 8054820 22 22 20 10 2 2 3 10 5 0 0.912 1.000 1.000 610 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(4), GABRA1(3), GABRA2(1), GABRA3(1), GABRA4(1), GABRA5(1), GABRA6(1), GPHN(4), SRC(3), UBQLN1(3) 12058520 22 21 22 11 2 4 5 8 2 1 0.904 1.000 1.000 611 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 6 AKT1(2), PIK3R1(5), PLCB1(3), PLCG1(4), PRKCA(2), VAV1(4) 10730507 20 19 19 11 3 3 2 5 7 0 0.978 1.000 1.000 612 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 9 ESR2(4), ITPKA(1), PDE1A(1), PDE1B(5), PLCB1(3), PLCB2(4) 10564147 18 18 18 11 6 2 0 4 6 0 0.974 1.000 1.000 613 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM2(1), CCL2(1), CCR5(1), CXCR4(1), FOS(1), JUN(2), MAPK14(1), PLCG1(4), PRKCA(2), PTK2B(3), SYT1(1) 13655108 18 16 17 10 2 4 2 6 4 0 0.965 1.000 1.000 614 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 10 ACTA1(1), ACTR2(2), ARPC1B(1), CDC42(1), WASF1(1) 6507194 6 6 6 5 0 3 0 3 0 0 0.974 1.000 1.000 615 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(3), SUCLA2(2) 2083524 5 5 5 3 0 2 1 2 0 0 0.875 1.000 1.000 616 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 TPI1(2) 1622802 2 2 2 2 0 0 2 0 0 0 0.932 1.000 1.000