rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(4), ANAPC2(1), ANAPC4(5), ANAPC5(1), ANAPC7(2), BTRC(2), CDC16(3), CDC20(1), CDC23(2), CDC27(1), CUL1(3), CUL2(1), CUL3(6), FBXW11(1), FBXW7(2), FZR1(3), ITCH(1), SKP2(1), SMURF1(1), SMURF2(2), TCEB1(3), TCEB2(1), UBA1(1), UBE2D1(2), UBE2D2(1), UBE2D3(2), UBE2E2(1), VHL(237), WWP2(3) 26842932 294 255 193 13 10 17 29 83 153 2 9.24e-12 <1.00e-15 <3.08e-13 2 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 ARNT(2), EIF1(2), EIF2B1(1), EIF2B2(1), EIF2B3(1), EIF2B5(2), EIF2S2(2), FLT1(7), FLT4(7), HIF1A(3), HRAS(1), KDR(5), NOS3(2), PIK3CA(10), PIK3R1(2), PLCG1(2), PRKCA(2), PTK2(1), PXN(1), SHC1(3), VHL(237) 22290046 294 252 193 16 12 21 29 80 151 1 5.37e-11 <1.00e-15 <3.08e-13 3 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(2), COPS5(1), EP300(11), HIF1A(3), JUN(2), NOS3(2), VHL(237) 11058426 258 235 158 10 8 11 27 68 143 1 2.16e-11 4.22e-15 8.66e-13 4 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 AKT1(1), AKT2(3), AKT3(1), GRB2(2), ILK(4), MAPK3(1), PDK1(1), PIK3CA(10), PIK3CD(1), PTEN(21), PTK2B(3), RBL2(2), SHC1(3), SOS1(5) 13295530 58 51 53 3 4 13 4 14 22 1 0.000370 1.93e-07 2.97e-05 5 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 7 HDAC1(2), MAX(5), SP1(2), SP3(2), TP53(15), WT1(3) 4549903 29 25 27 3 1 3 1 10 12 2 0.138 0.000105 0.0110 6 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD28(1), CD4(10), HLA-DRA(1), HLA-DRB1(1) 1356343 13 13 7 1 1 1 0 1 9 1 0.705 0.000111 0.0110 7 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 15 ARF1(1), ARF3(1), CDK2(2), CDK4(6), CDKN1A(1), CDKN2A(3), CFL1(1), E2F1(1), PRB1(6), TP53(15) 5336707 37 29 27 3 1 2 4 6 22 2 0.106 0.000127 0.0110 8 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT1(1), AKT2(3), AKT3(1), CDKN1A(1), ELK1(1), GRB2(2), HRAS(1), NGFR(1), NTRK1(5), PIK3CA(10), PIK3CD(1), SHC1(3), SOS1(5) 10262631 35 34 31 1 2 10 3 16 4 0 0.000681 0.000142 0.0110 9 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ACTR2(1), ARPC2(8), CDC42(1), PAK1(2), PDGFRA(5), PIK3CA(10), PIK3R1(2), WASL(6) 8954221 35 35 26 2 0 7 2 13 13 0 0.0123 0.000252 0.0173 10 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 17 ABCB1(4), AKT1(1), ATM(15), CDKN1A(1), CPB2(5), CSNK1A1(2), FHL2(1), HIF1A(3), IGFBP3(1), NFKBIB(1), TP53(15) 13158403 49 43 44 3 1 6 5 14 21 2 0.00597 0.000387 0.0238 11 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CD28(1), CD3E(1), CD3G(2), CD4(10) 2162366 14 14 8 1 1 1 1 2 8 1 0.536 0.000997 0.0558 12 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 9 CHUK(1), DNAJC3(2), EIF2S2(2), NFKB1(1), RELA(5), TP53(15) 6588881 26 22 21 1 1 6 1 5 10 3 0.0262 0.00251 0.129 13 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(2), CD34(2), CD3E(1), CD3G(2), CD4(10), CD8A(1), IL3(1), KITLG(2) 4130035 21 19 15 2 1 2 1 5 11 1 0.461 0.00329 0.156 14 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(2), GOT1(3), GOT2(2), TAT(1), TYR(5) 3135385 13 13 13 1 1 0 3 4 5 0 0.272 0.00415 0.183 15 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 AKT1(1), BCAR1(3), GRB2(2), ILK(4), ITGB1(4), MAPK3(1), PDK2(2), PIK3CA(10), PIK3R1(2), PTEN(21), PTK2(1), SHC1(3), SOS1(5) 12533863 59 50 54 7 3 11 3 17 24 1 0.0524 0.00482 0.198 16 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(2), GNAS(5), GNB1(2), PPP2CA(1), PRKAA2(4), PRKAB1(1), PRKACB(2), PRKACG(2), PRKAG1(4), PRKAG2(4), PRKAR1A(2), PRKAR2B(2) 9860005 31 29 28 1 3 3 2 12 11 0 0.00869 0.00947 0.352 17 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(1), BHMT(2), CTH(1), DNMT1(21), DNMT3A(12), DNMT3B(2), MARS(2), MARS2(3) 11258234 44 39 25 2 2 2 5 9 26 0 0.0585 0.00971 0.352 18 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(6), EGF(4), EGFR(9), HGS(2), RAB5A(1), TFRC(2) 8444563 24 23 22 0 4 1 5 6 8 0 0.00556 0.0108 0.369 19 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3E(1), CD3G(2), CD4(10), FYN(2), HLA-DRA(1), HLA-DRB1(1), PTPRC(6) 5701434 23 22 17 1 0 2 1 8 11 1 0.249 0.0126 0.407 20 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 AKT1(1), EIF2B5(2), EIF2S2(2), EIF4E(1), GSK3B(3), IGF1R(1), INPPL1(2), PDK2(2), PIK3CA(10), PIK3R1(2), PPP2CA(1), PTEN(21), RPS6KB1(2) 12904411 50 44 45 5 2 9 1 14 23 1 0.0179 0.0146 0.450 21 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(6), CTH(1), GOT1(3), GOT2(2), LDHB(1), LDHC(3), MPST(2) 4479216 18 18 16 2 1 0 2 5 10 0 0.390 0.0168 0.493 22 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(7), PDXK(2), PDXP(1), PSAT1(1) 3151763 11 11 11 0 2 1 0 6 2 0 0.0942 0.0182 0.495 23 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(1), BHMT(2), CTH(1), DNMT1(21), DNMT3A(12), DNMT3B(2), MARS(2), MARS2(3), MTAP(2), TAT(1) 13471379 47 42 28 2 3 2 6 10 26 0 0.0300 0.0187 0.495 24 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 AKT1(1), EIF4A2(3), EIF4B(3), EIF4E(1), EIF4G1(3), EIF4G2(3), EIF4G3(3), MKNK1(2), PDK2(2), PIK3CA(10), PIK3R1(2), PPP2CA(1), PTEN(21), RPS6KB1(2), TSC1(1), TSC2(5) 18200218 63 57 58 7 3 11 3 20 24 2 0.0140 0.0193 0.495 25 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RAN(1), RANBP2(20), RANGAP1(1) 5391270 22 19 16 1 1 6 2 4 9 0 0.0238 0.0219 0.540 26 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 33 A1BG(1), AKT1(1), AKT2(3), AKT3(1), CDKN2A(3), GRB2(2), GSK3A(1), GSK3B(3), IARS(4), INPP5D(2), PDK1(1), PIK3CA(10), PPP1R13B(3), PTEN(21), RPS6KA1(7), RPS6KB1(2), SHC1(3), SOS1(5), SOS2(3), TEC(5), YWHAB(1) 23615050 82 70 73 10 3 14 7 22 34 2 0.0149 0.0254 0.582 27 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD28(1), CD4(10), HLA-DRA(1), HLA-DRB1(1), IL4(1) 2419155 14 14 8 2 1 1 1 1 9 1 0.768 0.0262 0.582 28 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 CNR1(1), CNR2(2), DNMT1(21), MTNR1B(1), PTAFR(1), PTGER2(1), PTGER4(1), PTGFR(3), PTGIR(1), TBXA2R(2) 6746905 34 33 19 4 1 3 3 7 20 0 0.426 0.0265 0.582 29 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(2), CD3E(1), CD3G(2), CD4(10), CREBBP(5), CSK(3), GNAS(5), GNB1(2), HLA-DRA(1), HLA-DRB1(1), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2), PTPRC(6) 14449478 46 40 40 2 4 3 2 20 16 1 0.0124 0.0346 0.710 30 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(2), CD3E(1), CD3G(2), CD4(10), CREBBP(5), CSK(3), GNAS(5), GNB1(2), HLA-DRA(1), HLA-DRB1(1), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2), PTPRC(6) 14449478 46 40 40 2 4 3 2 20 16 1 0.0124 0.0346 0.710 31 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 FOS(1), FYN(2), JUN(2), MAPK14(1), THBS1(11) 4734833 17 15 14 1 1 2 2 6 6 0 0.133 0.0357 0.710 32 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(2), CD28(1), CD3E(1), CD3G(2), CD4(10), ICAM1(1), ITGAL(5), ITGB2(1), PTPRC(6) 7370757 29 26 23 3 1 3 2 10 12 1 0.268 0.0391 0.737 33 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(7), CCNE1(1), CCNE2(2), CDK2(2), CDK4(6), CDKN2A(3), E2F1(1), PRB1(6) 5784289 28 21 16 2 0 1 3 2 22 0 0.260 0.0395 0.737 34 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(1), ASL(4), CPS1(4), GLS(3), GOT1(3) 5133932 15 15 15 1 0 3 1 6 5 0 0.175 0.0413 0.748 35 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(6), ACO1(4), ACSS1(2), ACSS2(7), IDH1(2), IDH2(5), MDH1(1), SUCLA2(1) 8812773 28 23 24 2 1 5 3 8 10 1 0.0484 0.0583 0.997 36 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 ADRB2(2), AKT1(1), CALM2(1), GNAS(5), GNB1(2), NFKB1(1), NOS3(2), NPPA(1), PIK3CA(10), PIK3R1(2), RELA(5), SYT1(1) 11513017 33 32 27 3 1 10 1 12 8 1 0.0460 0.0586 0.997 37 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 AKT1(1), CASP9(1), CHUK(1), GHR(1), NFKB1(1), PIK3CA(10), PIK3R1(2), PPP2CA(1), RELA(5) 9326040 23 23 17 0 0 8 1 7 6 1 0.00343 0.0599 0.997 38 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(2), GNAS(5), GNB1(2), PRKACA(1), PRKAR1A(2) 4071859 12 12 12 1 1 1 0 9 1 0 0.287 0.0635 1.000 39 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(3), CYP2E1(1), NR1I3(1), PTGS1(2), PTGS2(4) 3459591 11 11 11 2 1 1 1 4 3 1 0.531 0.0647 1.000 40 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(3), GOT2(2), TAT(1) 1757669 6 6 6 1 1 0 2 0 3 0 0.569 0.0674 1.000 41 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(18), MAP2(4), PPP2CA(1), PRKACB(2), PRKACG(2), PRKAG1(4), PRKAR2B(2), PRKCE(2) 12102647 35 33 32 3 4 2 2 13 13 1 0.0464 0.0693 1.000 42 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 48 AKT1(1), AKT2(3), AKT3(1), BRD4(4), CBL(2), CDC42(1), CDKN2A(3), F2RL2(1), FLOT2(1), GRB2(2), GSK3A(1), GSK3B(3), INPPL1(2), IRS1(4), IRS4(1), LNPEP(2), MAPK3(1), PARD3(5), PDK1(1), PIK3CA(10), PIK3CD(1), PIK3R1(2), PTEN(21), PTPN1(1), RAF1(1), RPS6KA1(7), RPS6KB1(2), SHC1(3), SORBS1(1), SOS1(5), SOS2(3), YWHAB(1) 37359333 97 81 86 8 7 14 12 25 37 2 0.000266 0.0757 1.000 43 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 81 AIFM1(4), AKT1(1), AKT2(3), AKT3(1), APAF1(2), ATM(15), BID(1), BIRC2(2), BIRC3(2), CAPN1(1), CAPN2(2), CASP10(2), CASP7(1), CASP8(1), CASP9(1), CFLAR(1), CHUK(1), CSF2RB(1), DFFB(1), FAS(1), IKBKB(1), IL1B(1), IL1R1(1), IL1RAP(4), IL3(1), IRAK1(3), IRAK3(3), IRAK4(1), NFKB1(1), NFKB2(1), NTRK1(5), PIK3CA(10), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PPP3CA(2), PPP3CC(3), PRKACA(1), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2), RELA(5), RIPK1(1), TNFRSF10C(1), TNFRSF1A(1), TNFSF10(6), TP53(15), TRADD(2), TRAF2(1) 54726124 136 105 122 12 9 22 13 49 40 3 1.51e-05 0.0782 1.000 44 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(4), EGFR(9), MAP3K1(5), MAPK14(1), NCOR2(6), RARA(4), THRA(1) 11146341 30 26 28 2 2 4 5 8 11 0 0.0288 0.0806 1.000 45 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(3), ENO1(3), GPI(3), HK1(5), PFKL(1), PGK1(3), TPI1(1) 5888375 19 18 17 2 3 2 2 4 8 0 0.150 0.0836 1.000 46 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(2), CREM(1), FHL5(2), FSHR(2), GNAS(5), XPO1(5) 6080934 17 17 17 2 3 1 3 7 3 0 0.226 0.0940 1.000 47 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(2), MPO(4), PRDX1(1), PRDX5(1), TPO(4), TYR(5) 6283322 17 16 17 1 0 2 3 7 5 0 0.0918 0.0966 1.000 48 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD28(1), CD3E(1), CD3G(2), CD86(1), CTLA4(1), GRB2(2), HLA-DRA(1), HLA-DRB1(1), ICOS(2), ITK(1), PIK3CA(10), PIK3R1(2), PTPN11(1) 8302598 26 26 22 3 1 7 2 8 8 0 0.153 0.112 1.000 49 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 ECHS1(2), EHHADH(5), HADHA(2) 3225085 9 9 8 0 1 3 2 1 2 0 0.0459 0.113 1.000 50 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADM(1), ACADS(3), ECHS1(2), HADHA(2) 3565989 8 8 7 0 3 1 3 1 0 0 0.0479 0.120 1.000 51 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(2), ADRB2(2), GNAS(5), PLCE1(3), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2), RAP2B(2) 9420366 22 22 22 2 3 1 2 9 7 0 0.147 0.129 1.000 52 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(6), CPT1A(1), LEP(1), LEPR(1), PRKAA2(4), PRKAB1(1), PRKAG1(4), PRKAG2(4) 9711466 22 22 19 1 1 4 4 3 10 0 0.0146 0.129 1.000 53 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CD4(10), HLA-DRA(1), HLA-DRB1(1), IL1B(1), IL4(1) 3343993 14 14 8 2 0 2 1 1 9 1 0.816 0.131 1.000 54 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3E(1), CD3G(2) 778537 3 3 3 0 0 0 1 1 1 0 0.585 0.138 1.000 55 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(2), EGF(4), EGFR(9), GRB2(2), HRAS(1), MAPK3(1), PTPRB(3), RAF1(1), RASA1(3), SHC1(3), SOS1(5), SPRY1(1), SPRY2(2), SPRY4(10), SRC(1) 16509407 48 39 39 4 5 11 5 10 17 0 0.0164 0.139 1.000 56 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 HRAS(1), MMP14(1), MMP2(6), MMP9(1), RECK(1), TIMP3(4) 4896566 14 13 11 1 2 2 1 3 6 0 0.201 0.170 1.000 57 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(2), GLI2(4), GLI3(5), GSK3B(3), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2), SHH(1), SMO(3), SUFU(1) 10138090 27 26 25 3 5 3 2 10 7 0 0.0575 0.190 1.000 58 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(4), EGFR(9), ERBB3(4), NRG1(1), UBE2D1(2) 6806238 20 20 18 3 3 1 2 6 8 0 0.353 0.191 1.000 59 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 AKT1(1), CASP9(1), CDC42(1), CHUK(1), ELK1(1), HRAS(1), MAPK3(1), NFKB1(1), PIK3CA(10), PIK3R1(2), RAF1(1), RALA(2), RALBP1(1), RELA(5) 12565092 29 29 22 2 1 9 1 9 8 1 0.0291 0.193 1.000 60 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 ECHS1(2), EHHADH(5), HADH(1), HADHA(2), SIRT1(3), SIRT5(1), SIRT7(2), VNN2(1) 7846258 17 16 16 1 3 4 3 2 5 0 0.0309 0.195 1.000 61 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(2), CD28(1), CD3E(1), CD3G(2), CD8A(1), ICAM1(1), ITGAL(5), ITGB2(1), PTPRC(6) 6954807 20 18 20 2 1 3 2 9 5 0 0.144 0.202 1.000 62 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(2), ALPL(2), ALPP(3), ALPPL2(3), FPGS(2) 3825796 12 11 12 2 1 3 1 6 1 0 0.241 0.208 1.000 63 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GSR(1), GSS(1), NFKB1(1), NOX1(6), RELA(5), XDH(5) 6455005 19 16 14 1 1 2 3 4 8 1 0.149 0.223 1.000 64 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ECHS1(2), EHHADH(5), GCDH(3), HADHA(2), SDHB(1) 5173720 13 13 10 0 1 3 3 1 5 0 0.0336 0.225 1.000 65 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNGR1(2), IFNGR2(2), JAK1(4), JAK2(5), STAT1(3) 5533825 16 16 16 3 1 0 2 6 7 0 0.562 0.233 1.000 66 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(1), AASDH(3), AASDHPPT(2), AASS(4) 4697753 10 10 10 0 0 2 1 3 4 0 0.160 0.237 1.000 67 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNH(1), CDC25A(1), CDC25B(1), CDC25C(2), MNAT1(1), SHH(1), XPO1(5) 5730976 12 12 12 1 0 1 4 6 1 0 0.151 0.240 1.000 68 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ECHS1(2), EHHADH(5), HADHA(2), HADHB(3) 5572378 12 12 11 0 1 4 3 2 2 0 0.0187 0.243 1.000 69 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(3), GLS2(4) 2902056 7 7 7 0 0 1 0 5 1 0 0.273 0.243 1.000 70 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTR2(1), ARPC2(8), CDC42(1), WASL(6) 5343040 16 16 10 2 0 2 0 5 9 0 0.260 0.248 1.000 71 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CREBBP(5), EP300(11), NCOA3(5), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2), RARA(4) 13385859 33 31 30 3 3 1 7 13 9 0 0.0207 0.259 1.000 72 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(1), AASDHPPT(2), AASS(4) 3196928 7 7 7 0 0 1 1 2 3 0 0.273 0.272 1.000 73 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 GRB2(2), HRAS(1), PTK2B(3), SHC1(3), SOS1(5), SRC(1) 5690638 15 13 15 2 1 5 1 5 3 0 0.252 0.274 1.000 74 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(4), GNA12(1), PRKACB(2), PRKACG(2), PRKAG1(4), PRKAR2B(2) 6577458 15 15 15 2 2 2 3 5 3 0 0.189 0.275 1.000 75 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 16 ABL1(4), CDKN2A(3), E2F1(1), PIK3CA(10), PIK3R1(2), POLR1A(4), POLR1B(2), POLR1C(2), RB1(2), TP53(15) 12935489 45 41 40 6 1 10 2 15 15 2 0.0404 0.278 1.000 76 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 NRF1(1), UBE2A(2), UBE2D1(2), UBE2D2(1), UBE2D3(2), UBE2H(2), UBE2J1(1), UBE2J2(1), UBE3A(1) 6888798 13 13 13 1 1 2 1 5 4 0 0.163 0.288 1.000 77 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 ADCY1(2), AKT1(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), GNAS(5), GRB2(2), HRAS(1), MAPK14(1), MAPK3(1), PIK3CA(10), PIK3R1(2), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2), PRKCA(2), RPS6KA1(7), RPS6KA5(1), SOS1(5) 18932386 52 50 45 6 5 11 3 21 11 1 0.0305 0.291 1.000 78 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(4), ABCB11(3), ABCB4(5), ABCC1(8), ABCC3(7) 9684385 27 21 21 2 1 3 5 7 11 0 0.0589 0.292 1.000 79 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(2), ADH1B(2), ADH4(1), ADH6(1), ADHFE1(2) 3778160 8 8 7 1 1 0 0 5 2 0 0.569 0.306 1.000 80 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(2), CD3E(1), CD3G(2), ICAM1(1), ITGAL(5), ITGB2(1), PRF1(1) 5356831 13 12 13 1 0 3 2 4 4 0 0.142 0.307 1.000 81 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(1) 481049 1 1 1 0 0 0 1 0 0 0 0.751 0.311 1.000 82 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(2), ADRB2(2), CFTR(4), GNAS(5), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2) 8295712 21 21 21 3 3 2 0 11 5 0 0.317 0.314 1.000 83 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(1), ARG1(1), GLS(3), OAT(1), PRODH(1) 3619832 7 7 7 0 0 1 3 2 1 0 0.148 0.316 1.000 84 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 DCN(3), FMOD(3), LUM(1) 2353850 7 7 7 2 0 1 0 4 2 0 0.683 0.319 1.000 85 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 AKR1B10(2), DHRS2(1), DHRSX(5), PON3(4), RDH11(3) 5824116 15 14 10 1 1 0 3 4 7 0 0.363 0.321 1.000 86 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 62 AKT1(1), AKT2(3), AKT3(1), CDC42(1), CDK2(2), CDKN2A(3), CREB5(2), ERBB4(6), F2RL2(1), GAB1(1), GRB2(2), GSK3A(1), GSK3B(3), INPPL1(2), IRS1(4), IRS4(1), MET(6), PAK1(2), PAK2(2), PAK4(2), PAK6(4), PAK7(2), PARD3(5), PDK1(1), PIK3CA(10), PIK3CD(1), PPP1R13B(3), PREX1(6), PTEN(21), PTK2(1), PTPN1(1), RPS6KA1(7), RPS6KB1(2), SHC1(3), SOS1(5), SOS2(3), TSC1(1), TSC2(5), YWHAB(1) 49096208 128 102 116 16 10 18 9 40 48 3 0.00305 0.322 1.000 87 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CR1(7), CR2(2), HLA-DRA(1), HLA-DRB1(1), ICAM1(1), ITGAL(5), ITGB2(1), PTPRC(6) 9718536 24 23 24 3 1 2 1 12 8 0 0.275 0.326 1.000 88 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(1), CHUK(1), IKBKB(1), IL4(1), JUN(2), MAP3K1(5), MAP3K5(5), MAP4K5(4), MAPK14(1), NFKB1(1), RELA(5), TNFRSF9(1), TNFSF9(1), TRAF2(1) 13014003 30 26 27 3 0 4 1 11 13 1 0.224 0.345 1.000 89 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1QA(1), C1R(3), C1S(16), C2(4), C3(6), C5(5), C6(1), C7(3), C8A(1) 11483685 40 31 25 5 3 5 1 17 13 1 0.0911 0.347 1.000 90 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(1), GALNS(2), GLB1(5), GNS(1), GUSB(5), HEXA(3), IDS(2), IDUA(1), LCT(2), NAGLU(2) 9307263 24 21 24 3 2 3 3 9 7 0 0.0919 0.349 1.000 91 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(1), HPRT1(1), IMPDH1(1), POLB(1), POLD1(6), POLG(4), PRPS2(3), RRM1(2) 8012839 19 18 17 2 2 4 1 5 7 0 0.162 0.350 1.000 92 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ5(2), COQ6(1), NDUFA13(2) 2720684 5 5 5 0 2 1 0 1 1 0 0.218 0.351 1.000 93 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIAS(2) 1021533 2 2 2 1 0 0 0 1 1 0 0.880 0.367 1.000 94 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREM(1), FOS(1), JUN(2), MAPK3(1), POLR2A(8), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2) 8295387 21 20 21 3 6 2 2 6 5 0 0.134 0.379 1.000 95 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA1(1), NDUFA10(1), NDUFB2(1), NDUFB6(1), NDUFS1(5), NDUFS2(1), NDUFV1(1), NDUFV2(1) 4638002 12 12 12 2 0 1 1 7 3 0 0.529 0.382 1.000 96 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(2), CSF1R(4), EGF(4), EGFR(9), GRB2(2), MET(6), PDGFRA(5), PRKCA(2), SH3GLB1(2), SH3GLB2(1), SH3KBP1(1), SRC(1) 12895146 39 36 36 5 3 5 4 13 14 0 0.130 0.398 1.000 97 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(2), CDKN1A(1), GRIN1(2), HIF1A(3), JAK2(5), NFKB1(1), RELA(5) 8256148 19 18 16 2 0 4 1 6 7 1 0.183 0.402 1.000 98 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 GGT1(2), SHMT1(2), SHMT2(3) 2637325 7 7 7 2 0 1 1 2 3 0 0.687 0.403 1.000 99 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(1), CAT(2), EPX(2), MPO(4), PRDX1(1), PRDX5(1), SHMT1(2), SHMT2(3), TPO(4) 7662500 20 19 20 3 0 3 4 7 6 0 0.240 0.406 1.000 100 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(4), IDH1(2), IDH2(5), MDH1(1), SDHB(1), SUCLA2(1) 5926418 14 13 11 2 1 2 1 5 5 0 0.368 0.409 1.000 101 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM2(1), CAMK1(1), CAMK1G(3), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(1), CAMKK1(2), CAMKK2(2), SYT1(1) 7576560 15 15 14 0 1 1 2 6 5 0 0.0570 0.411 1.000 102 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(3), ENO2(1), ENO3(2), GOT1(3), GOT2(2), PAH(3), TAT(1), YARS(1) 5536066 16 14 16 3 2 1 4 3 6 0 0.376 0.414 1.000 103 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 AKT1(1), MAP2K3(2), MAP3K1(5), MAPK14(1), MAPK3(1), NFKB1(1), PIK3CA(10), PIK3R1(2), RB1(2), RELA(5), SP1(2) 12998076 32 31 26 4 1 9 1 11 9 1 0.0894 0.418 1.000 104 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(7), CD38(1), ENPP3(1), NADSYN1(1), NMNAT2(2), NNMT(1), NNT(6), NT5M(2), QPRT(1) 9614289 22 22 22 3 1 2 3 12 4 0 0.165 0.419 1.000 105 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 ASRGL1(4), GBA(2), GGT1(2), SHMT1(2), SHMT2(3) 3581936 13 13 10 4 0 1 1 3 8 0 0.720 0.424 1.000 106 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 PGLYRP2(2) 1107719 2 2 2 1 0 1 0 1 0 0 0.763 0.443 1.000 107 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(2), EPHX2(1), RDH11(3) 3085748 6 6 6 0 1 0 1 4 0 0 0.235 0.445 1.000 108 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG12(1), ATG3(1), ATG7(4), BECN1(1), IFNA1(1), IFNA14(1), IFNA16(1), IFNA21(2), IFNA5(1), IFNA7(1), IFNA8(2), PIK3C3(2), PIK3R4(4), PRKAA2(4), ULK1(1), ULK2(1), ULK3(3) 13894331 31 29 28 3 2 2 1 16 10 0 0.122 0.447 1.000 109 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(6), CS(2), MDH1(1), ME1(1), PC(3), PDHA1(1), SLC25A11(1) 6003931 15 15 15 2 1 3 0 6 5 0 0.204 0.456 1.000 110 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 13 CREBBP(5), DAXX(5), HRAS(1), PAX3(1), PML(2), RARA(4), RB1(2), SIRT1(3), SP100(1), TNFRSF1A(1), TP53(15) 12015404 40 35 38 6 5 3 5 13 12 2 0.0947 0.476 1.000 111 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 7 ATM(15), ATR(7), CDC25C(2), CHEK2(1), TP53(15) 10758508 40 35 38 7 1 5 3 12 17 2 0.402 0.489 1.000 112 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 GNAS(5), GNB1(2), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2), PRKCA(2) 6151940 17 16 17 3 2 2 0 9 4 0 0.417 0.490 1.000 113 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD28(1), CD3E(1), CD3G(2), IL2RA(2), IL4(1), TGFB2(1), TGFBR2(1), TGFBR3(3), TOB1(2), TOB2(3) 7049851 17 17 17 3 1 2 4 4 6 0 0.336 0.495 1.000 114 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(1), GPR171(1), GPR39(1), GPR45(3), GPR65(3), GPR75(1) 6370681 10 10 10 1 1 2 0 4 2 1 0.0882 0.501 1.000 115 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(1), GALNS(2), GLB1(5), GNS(1), GUSB(5), HEXA(3), HGSNAT(1), HPSE(1), HPSE2(3), HYAL1(1), HYAL2(1), IDS(2), IDUA(1), LCT(2), NAGLU(2), SPAM1(6) 13332496 37 31 37 5 4 6 4 15 8 0 0.0359 0.519 1.000 116 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 RAB1A(2), RAB3A(1), RAB4A(1), RAB5A(1) 2793408 5 5 5 0 1 0 1 1 2 0 0.222 0.523 1.000 117 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1QA(1), C1R(3), C1S(16), C2(4), C3(6), C5(5), C6(1), C7(3), C8A(1), MASP1(2), MASP2(1), MBL2(1) 14029008 44 35 29 6 5 6 1 18 13 1 0.0685 0.524 1.000 118 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDOA(1), ALDOB(3), TPI1(1) 2534776 5 5 5 3 0 0 1 0 4 0 0.993 0.534 1.000 119 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTR2(1), ARPC2(8), NCK1(1), NCKAP1(1), NTRK1(5), WASF2(2), WASF3(2), WASL(6) 9986316 26 23 19 3 0 2 1 11 12 0 0.192 0.534 1.000 120 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(3), BMPR1B(1), BMPR2(5) 4067154 9 7 9 0 0 1 2 4 2 0 0.0715 0.538 1.000 121 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(1), FOS(1), GRB2(2), HRAS(1), IL3(1), JAK2(5), MAPK3(1), PTPN6(3), RAF1(1), SHC1(3), SOS1(5), STAT5A(2), STAT5B(2) 11441752 28 26 27 4 4 3 3 10 8 0 0.175 0.542 1.000 122 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(5), GABBR1(3), GPRC5A(1), GPRC5B(2), GPRC5C(1), GRM1(4), GRM2(2), GRM3(3), GRM4(3), GRM5(7), GRM7(4), GRM8(2) 12621622 37 31 34 5 4 5 3 14 11 0 0.136 0.546 1.000 123 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1QA(1), C1R(3), C1S(16), C2(4), C3(6), C5(5), C6(1), C7(3), C8A(1), C8B(1), MASP1(2) 13681391 43 34 28 6 6 5 1 17 13 1 0.0812 0.557 1.000 124 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 16 APAF1(2), ATM(15), CCNE1(1), CDK2(2), CDK4(6), CDKN1A(1), E2F1(1), PCNA(2), RB1(2), TIMP3(4), TP53(15) 12080368 51 35 43 7 1 5 5 10 28 2 0.189 0.563 1.000 125 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(1), HGD(2) 1497521 3 3 3 1 0 0 1 0 2 0 0.902 0.568 1.000 126 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(1), IFNAR1(2), IFNB1(2), NFKB1(1), RELA(5), TRAF6(2) 7067516 13 13 10 1 1 5 0 1 5 1 0.250 0.581 1.000 127 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALT(3), UXS1(1) 2648399 4 4 4 1 0 1 2 1 0 0 0.620 0.585 1.000 128 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 B2M(2), ITGB1(4), KLRC1(2), KLRC2(3), KLRC3(1), MAPK3(1), PAK1(2), PIK3CA(10), PIK3R1(2), PTK2B(3), PTPN6(3), SYK(1), VAV1(3) 12279664 37 33 33 6 2 9 3 10 13 0 0.152 0.587 1.000 129 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 65 APAF1(2), ATM(15), ATR(7), BID(1), CASP8(1), CASP9(1), CCNB2(5), CCNB3(4), CCND2(1), CCNE1(1), CCNE2(2), CCNG2(1), CD82(3), CDK2(2), CDK4(6), CDKN1A(1), CDKN2A(3), CHEK2(1), FAS(1), GTSE1(2), IGFBP3(1), PTEN(21), RCHY1(1), RFWD2(2), RRM2(1), SERPINB5(3), STEAP3(2), THBS1(11), TP53(15), TP53I3(4), TP73(3), TSC2(5) 42330430 129 94 120 19 6 18 12 30 59 4 0.0135 0.587 1.000 130 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 HLA-DRA(1), HLA-DRB1(1), IL3(1) 1780309 3 3 3 0 0 0 0 0 3 0 0.826 0.588 1.000 131 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALT(3), UGP2(1), UXS1(1) 3354142 5 5 5 1 0 1 3 1 0 0 0.488 0.592 1.000 132 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDFT1(2), FDPS(1), IDI1(1) 2183565 4 4 4 1 0 0 0 2 2 0 0.892 0.605 1.000 133 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 44 ACTR2(1), AKT1(1), AKT2(3), AKT3(1), ARHGAP1(1), ARHGEF11(5), CDC42(1), CFL1(1), GDI2(1), INPPL1(2), ITPR1(4), ITPR2(9), ITPR3(4), LIMK1(4), MYLK(4), MYLK2(1), PAK1(2), PAK2(2), PAK4(2), PAK6(4), PAK7(2), PDK1(1), PIK3CA(10), PIK3CD(1), PIK3CG(3), PIK3R1(2), PITX2(2), PPP1R13B(3), PTEN(21), RACGAP1(1), RHO(1), ROCK1(4), ROCK2(2), SAG(5), WASL(6) 46030110 117 93 111 14 6 22 10 36 42 1 0.000496 0.612 1.000 134 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(7), CCNE1(1), CDK2(2), CUL1(3), E2F1(1), RB1(2), SKP2(1) 5788222 17 17 14 3 0 2 2 2 11 0 0.357 0.612 1.000 135 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(5), EIF4E(1), FBL(1), GPT(2), LDHB(1), LDHC(3), MAPK14(1), NCL(3) 5863439 17 15 16 4 0 0 4 6 7 0 0.682 0.615 1.000 136 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(1), IARS(4), LARS(3), LARS2(2), PDHA1(1), PDHA2(2), PDHB(1) 6720053 14 12 14 2 0 3 2 5 4 0 0.266 0.628 1.000 137 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 AKT1(1), GRB2(2), HRAS(1), MAPK3(1), MAPK7(1), MEF2D(1), NTRK1(5), PIK3CA(10), PIK3R1(2), PLCG1(2), RPS6KA1(7), SHC1(3) 12412009 36 34 27 5 4 7 1 13 10 1 0.148 0.630 1.000 138 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD4(10), CD8A(1), IL3(1), IL4(1) 3900358 13 13 7 3 0 2 1 1 8 1 0.887 0.632 1.000 139 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 44 AKT1(1), AKT2(3), AKT3(1), BRAF(2), EIF4B(3), FIGF(1), HIF1A(3), MAPK3(1), PGF(2), PIK3CA(10), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PRKAA2(4), RHEB(3), RICTOR(4), RPS6KA1(7), RPS6KA6(1), RPS6KB1(2), RPS6KB2(2), TSC1(1), TSC2(5), ULK1(1), ULK2(1), ULK3(3), VEGFC(2) 34531290 77 71 63 7 6 12 6 28 22 3 0.00194 0.643 1.000 140 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 4 FOSB(1), GRIA2(3), PPP1R1B(1) 2312513 5 5 5 2 1 1 0 3 0 0 0.748 0.646 1.000 141 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ECHS1(2), HADH(1), HADHA(2), HADHB(3), MECR(1) 5555699 9 8 9 0 1 2 3 3 0 0 0.0521 0.647 1.000 142 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BAG4(1), BIRC3(2), CASP8(1), RIPK1(1), TNFRSF1A(1), TRADD(2), TRAF2(1) 5178481 9 9 9 2 0 3 3 2 1 0 0.405 0.649 1.000 143 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDFT1(2), FDPS(1), IDI1(1), IDI2(1) 2908836 5 5 5 1 0 0 0 2 3 0 0.831 0.656 1.000 144 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 AKT1(1), FOS(1), GRB2(2), HRAS(1), JAK2(5), JUN(2), MAP3K1(5), MAPK3(1), PIK3CA(10), PIK3R1(2), RAF1(1), SOS1(5), STAT1(3), STAT5A(2), STAT5B(2) 18108538 43 42 39 6 3 9 4 20 7 0 0.0561 0.661 1.000 145 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 CASP8(1), CFL1(1), CFLAR(1) 2545277 3 3 3 1 0 0 2 0 1 0 0.770 0.662 1.000 146 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 DRD1(1), DRD2(1), GRM1(4), PLCB1(1), PPP1R1B(1), PPP2CA(1), PPP3CA(2), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2) 10437781 19 19 19 2 3 0 0 8 8 0 0.140 0.666 1.000 147 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 TPI1(1) 1058489 1 1 1 1 0 0 1 0 0 0 0.943 0.666 1.000 148 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(1), IFNA1(1), IFNB1(2), IKBKB(1), IL1B(1), IL1R1(1), IL1RAP(4), IRAK1(3), IRAK3(3), JUN(2), MAP2K3(2), MAP3K1(5), MAP3K7(1), MAPK14(1), NFKB1(1), RELA(5), TGFB2(1), TRAF6(2) 19456804 37 34 33 3 3 10 0 12 11 1 0.0228 0.670 1.000 149 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(1), CSAD(1), GAD2(1), GGT1(2) 3696433 5 5 5 1 0 0 2 1 2 0 0.469 0.672 1.000 150 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACOX1(1), ACOX3(2), ELOVL2(1), ELOVL5(6), FADS2(2), FASN(3), HADHA(2), PECR(1) 9051181 18 17 15 3 3 2 4 5 4 0 0.169 0.679 1.000 151 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(1), CTH(1), GGT1(2), MARS(2), MARS2(3), PAPSS1(2), PAPSS2(2), SCLY(2), SEPHS1(1) 7909012 16 16 16 3 2 0 5 4 5 0 0.314 0.680 1.000 152 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(1), MAPK14(1), NFKB1(1), RELA(5), TNFRSF13B(1), TRAF2(1), TRAF3(1), TRAF5(3), TRAF6(2) 9546530 16 15 13 1 0 4 0 6 5 1 0.183 0.692 1.000 153 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDK(1), CTH(1), MUT(2) 3173931 4 4 4 0 1 0 1 0 2 0 0.468 0.695 1.000 154 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 32 MAP2K7(1), MAPK10(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8IP1(3), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2), NFKB1(1), NFKB2(1), NFKBIB(1), NFKBIL1(1), PIK3CA(10), PIK3CD(1), PIK3R1(2), SYT1(1), TRAF2(1), TRAF3(1), TRAF5(3), TRAF6(2) 21095269 38 36 35 3 5 9 2 18 4 0 0.00271 0.700 1.000 155 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRNA1(2), STX1A(1), VAMP2(1) 2113258 4 4 4 3 0 0 0 1 3 0 0.986 0.706 1.000 156 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(1) 1070228 1 1 1 0 0 0 0 1 0 0 0.838 0.711 1.000 157 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(3), EXT2(1), EXTL1(1), EXTL2(7), EXTL3(3), GLCE(1), HS2ST1(1), HS3ST2(1), HS3ST5(1), HS6ST1(1), HS6ST2(1), NDST1(2), NDST2(3), NDST4(5) 13199599 31 29 25 3 2 4 3 8 14 0 0.0596 0.712 1.000 158 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(2), ICAM1(1), ITGAL(5), ITGAM(5), ITGB2(1), SELE(4) 6986089 18 18 18 4 0 6 2 4 6 0 0.285 0.713 1.000 159 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CCNE1(1), CDK2(2), CUL1(3), E2F1(1), NEDD8(2), RB1(2), SKP2(1) 5746773 12 12 11 2 0 1 1 2 8 0 0.519 0.714 1.000 160 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CCL3(1), FLT3(6), IL3(1), KITLG(2), TGFB2(1) 5477520 11 11 11 2 0 1 1 4 5 0 0.608 0.715 1.000 161 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(2), POLR2A(8), POLR2B(4), POLR2F(3), POLR2I(1), POLRMT(2) 8545476 20 19 18 3 1 4 4 3 8 0 0.193 0.719 1.000 162 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(2), EIF2AK4(4), EIF2B5(2), EIF2S2(2), EIF5(2), GSK3B(3) 7634764 15 14 13 2 0 1 2 4 8 0 0.425 0.733 1.000 163 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 EGF(4), EGFR(9), ELK1(1), FOS(1), GRB2(2), HRAS(1), JAK1(4), JUN(2), MAP3K1(5), MAPK3(1), PIK3CA(10), PIK3R1(2), PLCG1(2), PRKCA(2), RAF1(1), RASA1(3), SHC1(3), SOS1(5), STAT1(3), STAT3(3), STAT5A(2) 24617467 66 59 59 10 6 13 5 21 21 0 0.0848 0.734 1.000 164 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(2), SUCLA2(1) 1344260 3 3 3 2 0 2 0 1 0 0 0.868 0.735 1.000 165 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 25 AKT1(1), AKT2(3), AKT3(1), GRB2(2), GSK3A(1), GSK3B(3), IL4R(2), IRS1(4), JAK1(4), JAK3(3), MAP4K1(1), MAPK3(1), PDK1(1), PIK3CA(10), PIK3CD(1), PIK3R1(2), PPP1R13B(3), RAF1(1), SHC1(3), SOS1(5), SOS2(3), STAT6(4) 22819697 59 52 54 9 6 13 9 20 11 0 0.0243 0.744 1.000 166 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 25 ABL1(4), ATM(15), ATR(7), CCNA1(7), CCNE1(1), CDC25A(1), CDK2(2), CDK4(6), CDKN1A(1), CDKN2A(3), E2F1(1), GSK3B(3), HDAC1(2), RB1(2), SKP2(1), TGFB2(1), TP53(15) 19775709 72 56 62 12 1 9 6 17 37 2 0.151 0.757 1.000 167 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(2), ICAM1(1), ITGA4(2), ITGAL(5), ITGB1(4), ITGB2(1), SELE(4) 8049451 19 18 19 4 0 5 3 5 6 0 0.325 0.763 1.000 168 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 12 ATM(15), CDC25A(1), CDC25B(1), CDC25C(2), CDK2(2), CDK4(6), MYT1(2), RB1(2), TP53(15), WEE1(1) 11800521 47 37 42 8 1 5 5 13 21 2 0.268 0.766 1.000 169 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(4), ATIC(2), FTCD(2), GART(1), MTHFD1(4), MTHFD1L(3), MTHFR(1), SHMT1(2), SHMT2(3) 12548008 22 21 22 3 3 4 0 10 5 0 0.181 0.770 1.000 170 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 DHRS2(1), DHRSX(5), LCMT1(1), LCMT2(3), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(3) 9596586 18 17 14 1 1 2 2 5 8 0 0.213 0.772 1.000 171 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 16 ADAM10(4), ANKRD1(1), EIF4E(1), IFRD1(1), IL1R1(1), NR4A3(2), WDR1(1) 7034714 11 11 11 2 0 3 2 3 3 0 0.387 0.779 1.000 172 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(2) 2037938 2 2 2 1 0 1 0 1 0 0 0.891 0.784 1.000 173 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 17 DNAJA3(1), IFNGR1(2), IFNGR2(2), IKBKB(1), JAK2(5), NFKB1(1), RB1(2), RELA(5), TNFRSF1A(1), TP53(15), USH1C(3), WT1(3) 11741949 41 35 36 7 1 5 3 9 20 3 0.345 0.785 1.000 174 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(6), C5(5), C6(1), C7(3), C8A(1) 8544986 16 16 16 3 2 2 1 8 3 0 0.325 0.785 1.000 175 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(1), CDC25B(1), CDKN1A(1), NEK1(3), WEE1(1) 4906037 7 6 7 1 0 2 0 3 2 0 0.447 0.796 1.000 176 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD28(1), CD86(1), HLA-DRA(1), HLA-DRB1(1), IFNGR1(2), IFNGR2(2), IL12RB1(2), IL12RB2(2), IL18R1(1), IL2RA(2), IL4(1), IL4R(2) 8183213 18 17 18 4 4 1 1 5 7 0 0.531 0.799 1.000 177 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 IFNGR1(2), JAK1(4), JAK2(5), PTPRU(4), STAT1(3) 7501440 18 16 18 4 2 0 2 9 5 0 0.570 0.800 1.000 178 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(3), GUSB(5), RPE(1), UCHL3(1), UGT1A1(3), UGT1A4(2), UGT1A5(1), UGT1A6(3), UGT1A7(3), UGT2B15(1), UGT2B4(2) 11577235 25 22 25 4 2 5 3 5 10 0 0.253 0.802 1.000 179 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 51 AGT(1), AKT1(1), CALM2(1), CALR(1), CAMK1(1), CAMK1G(3), CAMK4(1), CREBBP(5), CSNK1A1(2), ELSPBP1(1), F2(2), GATA4(2), GSK3B(3), HRAS(1), MAPK14(1), MAPK3(1), MYH2(9), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), NPPA(1), PIK3CA(10), PIK3R1(2), PPP3CA(2), PPP3CC(3), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2), RAF1(1), RPS6KB1(2), SYT1(1) 32539613 81 67 73 8 7 10 6 26 32 0 0.00187 0.805 1.000 180 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 APAF1(2), CASP9(1), DAXX(5), FAS(1), HSPB2(2), MAPKAPK2(1) 7180948 12 12 12 2 2 1 0 7 2 0 0.359 0.807 1.000 181 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(2), ARHGAP5(4), ARHGDIB(1), CASP1(2), CASP10(2), CASP8(1), CASP9(1), JUN(2), PRF1(1) 8351688 16 15 16 3 0 3 1 7 5 0 0.481 0.807 1.000 182 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(3), AP2A1(2), BIN1(1), CALM2(1), DNM1(1), EPN1(1), EPS15(1), PICALM(1), PPP3CA(2), PPP3CC(3), SYNJ1(5), SYNJ2(5), SYT1(1) 14557266 27 27 27 4 1 6 1 12 7 0 0.166 0.808 1.000 183 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(4), ATIC(2), GART(1), MTHFD1(4), MTHFD1L(3), MTHFR(1), SHMT1(2), SHMT2(3) 11867713 20 19 20 3 3 4 0 8 5 0 0.224 0.809 1.000 184 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(1), POLD1(6), POLE(4), POLG(4), POLL(2), POLQ(9) 10720371 26 23 24 3 2 0 0 11 13 0 0.315 0.811 1.000 185 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADM(1), ACADS(3), ACSL1(2), ACSL3(13), ACSL4(1), CPT1A(1), CPT2(1), EHHADH(5), HADHA(2), PECR(1), SCP2(2) 11117341 32 28 20 6 2 5 6 14 5 0 0.117 0.811 1.000 186 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA3(2), PSMA4(2), PSMA6(3), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(1), RPN1(2), RPN2(1), UBE2A(2), UBE3A(1) 8767774 17 17 17 3 0 1 2 8 6 0 0.577 0.814 1.000 187 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(2), FDFT1(2), FDPS(1), IDI1(1), LSS(2), MVK(1), PMVK(1), VKORC1(1) 7266876 11 11 11 1 0 0 1 7 3 0 0.460 0.814 1.000 188 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 AKT1(1), CCNE1(1), CDK2(2), CDK4(6), CDKN1A(1), E2F1(1), HRAS(1), MAPK3(1), NFKB1(1), PAK1(2), PIK3CA(10), PIK3R1(2), RAF1(1), RB1(2), RELA(5) 13308701 37 32 28 5 1 8 3 10 14 1 0.143 0.816 1.000 189 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(7), AXIN1(2), BTRC(2), CREBBP(5), CSNK1A1(2), CTBP1(1), CTNNB1(1), DVL1(1), FZD1(1), GSK3B(3), HDAC1(2), MAP3K7(1), PPARD(1), PPP2CA(1), TLE1(4), WIF1(4) 18971371 38 34 32 3 2 2 5 14 15 0 0.0177 0.817 1.000 190 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 33 AKT1(1), AKT2(3), AKT3(1), CD19(1), CDKN2A(3), FLOT2(1), GAB1(1), ITPR1(4), ITPR2(9), ITPR3(4), PDK1(1), PIK3CA(10), PITX2(2), PLCG2(2), PPP1R13B(3), PREX1(6), PTEN(21), PTPRC(6), RPS6KA1(7), RPS6KB1(2), SAG(5), SYK(1), TEC(5), VAV1(3) 36400706 102 89 95 16 7 18 10 29 36 2 0.00956 0.827 1.000 191 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(1), F13B(2), HSD17B1(1), HSD17B2(1), HSD3B1(1) 5329177 6 6 6 0 1 1 2 2 0 0 0.138 0.832 1.000 192 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 CAPN1(1), CSNK1A1(2), GSK3B(3), MAPT(3), PPP2CA(1) 6119567 10 10 8 0 0 1 1 1 7 0 0.108 0.836 1.000 193 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 AOC2(3), AOC3(1), CES1(7) 3671618 11 11 9 3 0 1 1 4 5 0 0.640 0.844 1.000 194 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 AKT1(1), APC(7), AXIN1(2), CTNNB1(1), DVL1(1), FZD1(1), GNAI1(1), GSK3B(3), IRAK1(3), LBP(1), LEF1(1), LY96(1), NFKB1(1), PIK3CA(10), PIK3R1(2), PPP2CA(1), RELA(5), TLR4(2) 19541154 44 44 36 6 1 11 5 14 12 1 0.0302 0.844 1.000 195 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 HLCS(1), SPCS1(1) 2028703 2 2 2 1 0 0 0 1 1 0 0.869 0.847 1.000 196 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAS1(5), ALAS2(3), CPOX(5), FECH(2), PPOX(1), UROD(1) 5062066 17 17 12 6 0 0 3 6 8 0 0.893 0.851 1.000 197 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(1), CAT(2), EPX(2), MPO(4), MTHFR(1), SHMT1(2), SHMT2(3), TPO(4) 7542016 19 18 19 4 0 3 3 7 6 0 0.440 0.853 1.000 198 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(5), F13A1(1), F2(2), FGA(2), FGB(1), FGG(5), PLAT(4), PLG(5) 8931892 25 23 20 5 1 0 4 10 10 0 0.399 0.854 1.000 199 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(1), GRB2(2), IL4(1), IL4R(2), IRS1(4), JAK1(4), JAK3(3), RPS6KB1(2), SHC1(3), STAT6(4) 9209886 26 24 26 5 4 3 4 8 7 0 0.294 0.855 1.000 200 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 ELK1(1), FOS(1), GRB2(2), HRAS(1), INSR(4), IRS1(4), JUN(2), MAPK3(1), PIK3CA(10), PIK3R1(2), PTPN11(1), RAF1(1), RASA1(3), SHC1(3), SOS1(5) 16234316 41 38 36 7 5 12 3 14 7 0 0.0932 0.860 1.000 201 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(2), IL4(1), JUNB(1), MAF(1), MAP2K3(2), MAPK14(1), NFATC1(2), NFATC2(5), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2) 7255388 23 22 21 5 4 0 1 10 8 0 0.439 0.864 1.000 202 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 CHUK(1), IKBKAP(2), IKBKB(1), MAP3K1(5), NFKB1(1), RELA(5), TRAF3(1), TRAF6(2) 12025983 18 16 15 1 0 5 0 3 9 1 0.108 0.867 1.000 203 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(1) 1350624 1 1 1 1 0 0 0 1 0 0 0.940 0.867 1.000 204 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CHUK(1), CREBBP(5), EP300(11), IKBKB(1), NFKB1(1), RELA(5), RIPK1(1), TNFRSF1A(1), TRADD(2), TRAF6(2) 14388684 30 26 24 4 1 4 6 5 13 1 0.165 0.869 1.000 205 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(1), CAMK1G(3), HDAC9(2), MEF2D(1) 5358220 7 7 6 1 1 0 0 2 4 0 0.614 0.873 1.000 206 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 DAB1(5), FYN(2), LRP8(4), RELN(5), VLDLR(2) 9287001 18 17 13 2 1 3 0 4 10 0 0.530 0.876 1.000 207 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 22 ATM(15), ATR(7), BRCA1(5), CDC25A(1), CDC25B(1), CDC25C(2), CDKN1A(1), CHEK2(1), EP300(11), MYT1(2), PRKDC(10), RPS6KA1(7), TP53(15), WEE1(1) 28513136 79 62 70 11 2 9 8 29 28 3 0.0480 0.880 1.000 208 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(2), ADH1B(2), ADH4(1), ADH5(1), ADH6(1), ADHFE1(2), ALDH1A3(3), ALDH1B1(1), ALDH2(2), ALDH7A1(1) 8806978 16 16 13 3 1 1 0 7 7 0 0.654 0.885 1.000 209 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ADH1A(2), ADH1B(2), ADH4(1), ADH6(1), ADHFE1(2), ALDH1A3(3), ALDH3B1(3), ALDH3B2(2), AOC2(3), AOC3(1), AOX1(7), DBH(2), DCT(4), DDC(2), FAH(1), GOT1(3), GOT2(2), HGD(2), MAOA(1), TAT(1), TH(2), TPO(4), TYR(5) 20485286 56 49 52 10 5 4 7 20 20 0 0.243 0.886 1.000 210 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(5), EP300(11), LPL(2), NCOA1(2), NCOA2(9), PPARG(2) 12108595 31 23 22 4 2 1 4 8 16 0 0.0951 0.887 1.000 211 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(1), CHAT(4), PCYT1A(1), PDHA1(1), PDHA2(2), SLC18A3(1) 4258777 10 10 8 3 0 2 0 2 6 0 0.887 0.889 1.000 212 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 B3GALT5(1), GBGT1(2), GLA(1), HEXA(3), ST3GAL1(1), ST8SIA1(2) 6814216 10 10 10 2 1 2 1 5 1 0 0.313 0.889 1.000 213 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(5), AGT(1), AGTR1(2), BDKRB2(1), KNG1(2), NOS3(2), REN(1) 6220091 14 13 12 3 1 3 1 3 6 0 0.454 0.889 1.000 214 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CCNE1(1), CDK2(2), CUL1(3), E2F1(1), FBXW7(2), RB1(2) 5632778 11 11 11 3 0 1 1 2 7 0 0.709 0.891 1.000 215 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(4), POLR1B(2), POLR1C(2), POLR2A(8), POLR2B(4), POLR2F(3), POLR2I(1), POLR3A(4), POLR3B(3), POLR3G(1), POLR3H(1), POLR3K(1) 15491738 34 31 32 4 1 5 3 14 11 0 0.0927 0.893 1.000 216 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 DHCR7(2), FDFT1(2), FDPS(1), HMGCS1(1), IDI1(1), LSS(2), MVK(1), NSDHL(3), PMVK(1) 8670732 14 12 14 1 0 2 1 7 4 0 0.244 0.896 1.000 217 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 ANP32A(2), CREBBP(5), DFFB(1), PRF1(1) 6823412 9 8 9 0 2 1 2 2 2 0 0.0619 0.897 1.000 218 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(3), ADRBK2(1), ARRB2(1), CALM2(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CLCA1(1), CLCA4(2), CNGA3(3), CNGA4(2), CNGB1(6), PDC(1), PDE1C(1), PRKACA(1), PRKACB(2), PRKACG(2), PRKG1(3), PRKG2(2) 20348083 36 34 33 4 5 5 2 14 10 0 0.0703 0.899 1.000 219 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 EPHA4(1), EPHB1(1), FYN(2), ITGA1(5), ITGB1(4), L1CAM(5), SELP(2) 10345754 20 19 19 4 2 2 2 8 6 0 0.367 0.900 1.000 220 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 CFL1(1), CHN1(2), LIMK1(4), MAP3K1(5), MYL2(1), MYLK(4), NCF2(1), PAK1(2), PDGFRA(5), PIK3CA(10), PIK3R1(2), PLD1(2), PPP1R12B(1), RALBP1(1), RPS6KB1(2), TRIO(2), VAV1(3) 23141692 48 45 43 5 1 7 3 20 17 0 0.0541 0.900 1.000 221 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CDC25A(1), CDC25B(1), CDC25C(2), CSK(3), GRB2(2), PRKCA(2), PTPRA(3), SRC(1) 6030235 15 13 15 4 0 5 1 6 3 0 0.505 0.903 1.000 222 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(2), GBA(2), MPO(4), TPO(4) 5410392 12 11 12 3 0 2 2 4 4 0 0.510 0.905 1.000 223 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(1), ALDH1A2(1), RDH5(2) 2542945 4 4 4 2 0 0 2 1 1 0 0.861 0.908 1.000 224 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 10 CASP7(1), DFFB(1), TOP2A(4), TOP2B(1) 6729138 7 7 7 0 2 1 0 2 2 0 0.240 0.909 1.000 225 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(1), ACADM(1), ACADS(3), ALDH1A3(3), ALDH1B1(1), ALDH2(2), ALDH7A1(1), AOX1(7), BCAT1(1), BCKDHA(1), DLD(2), ECHS1(2), EHHADH(5), HADH(1), HADHA(2), HADHB(3), HIBADH(1), HMGCS1(1), HMGCS2(1), IVD(2), MCCC1(2), MCCC2(3), MCEE(1), MUT(2), OXCT1(1), PCCA(1), PCCB(3) 28556934 54 52 50 6 4 6 11 18 15 0 0.0190 0.914 1.000 226 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH2(2), ECHS1(2), EHHADH(5), HADHA(2) 7977735 17 17 14 4 1 4 3 3 6 0 0.456 0.915 1.000 227 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 PAPSS1(2), PAPSS2(2), SULT2A1(1), SUOX(4) 4078790 9 9 9 3 1 0 3 1 4 0 0.701 0.919 1.000 228 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 ATF1(2), CASP2(1), CHUK(1), IKBKB(1), JUN(2), LTA(1), MAP2K3(2), MAP3K1(5), MAPK14(1), NFKB1(1), RELA(5), RIPK1(1), TANK(1), TNFRSF1A(1), TRADD(2), TRAF2(1) 15660452 28 25 25 4 1 4 2 11 9 1 0.305 0.920 1.000 229 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(2), NDUFA1(1), SDHA(1), SDHB(1), SDHD(1), UQCRC1(1) 4300772 7 6 7 2 1 2 1 3 0 0 0.532 0.921 1.000 230 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ADCY1(2), CDC25C(2), GNAI1(1), GNAS(5), GNB1(2), HRAS(1), MAPK3(1), MYT1(2), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2), RPS6KA1(7), SRC(1) 13011651 32 30 28 5 5 2 0 16 8 1 0.260 0.921 1.000 231 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 AKT1(1), CHRNB1(2), MUSK(1), PIK3CA(10), PIK3R1(2), PTK2(1), PTK2B(3), SRC(1), TERT(5) 10697791 26 24 23 5 2 11 1 8 4 0 0.178 0.922 1.000 232 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 B3GNT1(1), GCNT2(2), ST8SIA1(2) 3802567 5 5 5 2 1 1 1 2 0 0 0.646 0.923 1.000 233 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCL3(1), CD28(1), CD4(10), CXCR4(1), IFNGR1(2), IFNGR2(2), IL12RB1(2), IL12RB2(2), IL18R1(1), IL4(1), IL4R(2), TGFB2(1) 13175511 26 25 20 4 4 2 2 6 11 1 0.380 0.926 1.000 234 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CD4(10), HLA-DRA(1), HLA-DRB1(1), IFNA1(1), IFNB1(2), IL15(1), IL3(1), IL4(1), LTA(1), TGFB2(1) 8368491 20 19 14 4 0 4 1 4 10 1 0.719 0.926 1.000 235 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CCNA1(7), CCND2(1), CCNE1(1), CCNH(1), CDC25A(1), CDK2(2), CDK4(6), CDKN1A(1), CDKN2A(3), CDKN2C(1), E2F1(1), RB1(2) 10455994 27 24 21 6 0 1 3 6 17 0 0.582 0.927 1.000 236 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(5), KHK(3), LCT(2), MPI(1), PYGL(1), PYGM(3), TPI1(1) 8882163 16 15 16 3 4 0 3 6 3 0 0.278 0.927 1.000 237 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 38 AKT1(1), ATF2(1), CDC42(1), DLD(2), DUSP10(1), DUSP4(1), DUSP8(1), GAB1(1), IL1R1(1), JUN(2), MAP2K5(1), MAP2K7(1), MAP3K1(5), MAP3K10(3), MAP3K11(1), MAP3K12(4), MAP3K13(2), MAP3K2(2), MAP3K3(2), MAP3K4(5), MAP3K5(5), MAP3K7(1), MAP3K9(3), MAPK10(1), MAPK7(1), MAPK9(2), NFATC3(5), NR2C2(1), PAPPA(1), SHC1(3), TP53(15), TRAF6(2), ZAK(3) 32617384 81 69 76 12 6 10 9 30 24 2 0.0353 0.928 1.000 238 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 AKT1(1), APC(7), AR(1), ASAH1(1), BRAF(2), EGFR(9), GNA15(1), GNAI1(1), ITPKB(2), ITPR1(4), ITPR2(9), ITPR3(4), KCNJ3(3), MAPK10(1), MAPK14(1), PHKA2(3), PIK3CA(10), PIK3CD(1), PIK3R1(2), PITX2(2), RAF1(1), SRC(1) 34879153 67 52 62 7 8 15 10 24 9 1 0.000558 0.928 1.000 239 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNA1(1), IFNAR1(2), IFNB1(2), JAK1(4), STAT1(3), STAT2(6), TYK2(6) 7056471 24 20 23 6 2 5 3 5 9 0 0.427 0.929 1.000 240 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(4), CS(2), GRHPR(2), MDH1(1), MTHFD1(4), MTHFD1L(3) 8497018 16 16 16 4 3 1 1 10 1 0 0.454 0.930 1.000 241 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(6), C5(5), C6(1), C7(3), ICAM1(1), ITGA4(2), ITGAL(5), ITGB1(4), ITGB2(1), SELP(2), SELPLG(2), VCAM1(3) 16371292 35 33 35 7 3 5 5 15 7 0 0.181 0.933 1.000 242 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 11 CHST11(1), CHST12(2), PAPSS1(2), PAPSS2(2), SULT1A1(1), SULT2A1(1), SUOX(4) 5671732 13 13 13 4 2 1 3 1 6 0 0.745 0.934 1.000 243 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CHPT1(2), LCMT1(1), LCMT2(3), PCYT1A(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(3) 9072873 15 14 15 2 1 2 1 6 5 0 0.481 0.935 1.000 244 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 OXCT1(1) 2272771 1 1 1 1 0 0 0 0 1 0 0.967 0.936 1.000 245 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CALM2(1), CAMK1(1), CAMK1G(3), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(1), MEF2D(1), PPP3CA(2), PPP3CC(3), SYT1(1) 13416740 17 17 16 1 2 1 1 5 8 0 0.116 0.936 1.000 246 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 LPL(2), PPARG(2), RETN(1) 3623001 5 5 5 2 1 1 0 1 2 0 0.732 0.936 1.000 247 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), IL4R(2), JAK1(4), JAK2(5), TYK2(6) 6769437 18 18 17 5 1 0 3 6 8 0 0.830 0.936 1.000 248 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), IL4R(2), JAK1(4), JAK2(5), TYK2(6) 6769437 18 18 17 5 1 0 3 6 8 0 0.830 0.936 1.000 249 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA3(2), PSMA4(2), PSMA6(3), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(1) 5547482 11 11 11 3 0 1 1 5 4 0 0.847 0.939 1.000 250 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(1), FUCA2(1), GLB1(5), HEXA(3), LCT(2), MAN2C1(5), MANBA(1), NEU1(1) 10318615 19 18 19 4 1 3 2 10 3 0 0.366 0.939 1.000 251 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(3), ALDH1B1(1), ALDH2(2), ALDH7A1(1), MIOX(2) 5551696 9 9 7 2 0 2 0 1 6 0 0.742 0.940 1.000 252 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR2(2), PDE1A(1), PDE1B(5), PLCB1(1), PLCB2(2), TRH(8) 7190204 19 17 12 9 3 2 0 3 11 0 0.986 0.941 1.000 253 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(2), TH(2), TPH1(1) 3765718 5 5 5 2 1 1 1 1 1 0 0.762 0.941 1.000 254 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM2(1), DLG4(1), GRIN1(2), GRIN2A(6), GRIN2B(6), NOS1(9), PPP3CA(2), PPP3CC(3), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2), PRKCA(2), SYT1(1) 16559708 41 36 40 8 7 7 1 19 7 0 0.147 0.942 1.000 255 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS(6), CARS2(3), CTH(1), GOT1(3), GOT2(2), LDHAL6B(1), LDHB(1), LDHC(3), MPST(2), SULT1B1(2), SULT1C4(1), SULT4A1(1) 8238711 26 26 24 6 2 1 2 9 12 0 0.742 0.943 1.000 256 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(1), ITPKB(2) 3678919 3 3 3 0 1 1 0 0 1 0 0.298 0.944 1.000 257 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(3), CLOCK(1), PER1(4) 5502413 8 8 7 2 0 0 2 2 4 0 0.688 0.945 1.000 258 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 FUT6(2), ST3GAL3(3) 2932945 5 5 4 2 1 1 0 0 3 0 0.882 0.948 1.000 259 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 DHRS2(1), DHRSX(5), ECHS1(2), EHHADH(5), ESCO1(2), ESCO2(1), FN3K(1), GCDH(3), HADHA(2), PNPLA3(2), SH3GLB1(2), YOD1(1) 16967600 27 25 20 2 1 4 3 4 15 0 0.153 0.948 1.000 260 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACADM(1), ACADS(3), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH2(2), AOX1(7), BCAT1(1), BCKDHA(1), ECHS1(2), EHHADH(5), HADHA(2), HADHB(3), HIBADH(1), IVD(2), MCCC1(2), MCCC2(3), MCEE(1), MUT(2), OXCT1(1), PCCA(1), PCCB(3) 23862148 49 47 45 7 3 6 10 16 14 0 0.0726 0.950 1.000 261 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(4), CS(2), GRHPR(2), MDH1(1), MTHFD1(4), MTHFD1L(3) 8913722 16 16 16 4 3 1 1 10 1 0 0.451 0.950 1.000 262 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYC(2), RB1(2), SP1(2), SP3(2) 4473590 8 8 8 3 0 1 0 2 5 0 0.894 0.954 1.000 263 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 ATF2(1), CDC42(1), DAXX(5), ELK1(1), GRB2(2), HRAS(1), HSPB2(2), MAP3K1(5), MAP3K5(5), MAP3K7(1), MAP3K9(3), MAPK14(1), MAPKAPK2(1), MAX(5), MEF2D(1), MKNK1(2), PLA2G4A(1), RIPK1(1), RPS6KA5(1), SHC1(3), STAT1(3), TGFB2(1), TRADD(2), TRAF2(1) 24138594 50 43 48 7 6 5 2 24 13 0 0.0707 0.955 1.000 264 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CCL2(1), IL1B(1), MST1R(1) 3807978 3 3 3 1 0 1 0 1 1 0 0.845 0.955 1.000 265 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 B3GALT1(1), B3GALT2(2), B3GALT5(1), B3GNT5(1), ST3GAL3(3), ST3GAL4(1) 4537861 9 8 8 4 1 0 1 1 6 0 0.938 0.955 1.000 266 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ALDH1A3(3), ALDH3B1(3), ALDH3B2(2), AOC2(3), AOC3(1), DDC(2), EPX(2), GOT1(3), GOT2(2), MAOA(1), MPO(4), PRDX1(1), PRDX5(1), TAT(1), TPO(4) 14132890 33 29 30 5 2 3 8 7 13 0 0.156 0.955 1.000 267 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 ATF1(2), BRAF(2), CREB5(2), DUSP4(1), DUSP9(1), EEF2K(1), EIF4E(1), GRB2(2), MAPK3(1), MKNK1(2), MKNK2(1), MOS(1), NFKB1(1), RAP1A(1), RPS6KA1(7), SHC1(3), SOS1(5), SOS2(3), TRAF3(1) 19323486 38 35 34 5 4 5 5 13 9 2 0.153 0.956 1.000 268 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 CHUK(1), IKBKAP(2), IKBKB(1), LTA(1), MAP3K1(5), NFKB1(1), RELA(5), RIPK1(1), TANK(1), TRAF2(1), TRAF3(1) 14638426 20 17 17 2 1 4 0 5 9 1 0.171 0.956 1.000 269 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 ADCY1(2), AKT1(1), CSF2RB(1), IGF1R(1), IL3(1), KITLG(2), PIK3CA(10), PIK3R1(2), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2) 14196205 28 28 25 5 5 6 1 11 5 0 0.104 0.956 1.000 270 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 22 AKT1(1), EIF4A2(3), EIF4E(1), EIF4G1(3), EIF4G2(3), EIF4G3(3), GHR(1), IRS1(4), MAPK14(1), MAPK3(1), MKNK1(2), PABPC1(9), PDK2(2), PIK3CA(10), PIK3R1(2), PRKCA(2), PTEN(21), RPS6KB1(2) 18319467 71 62 68 14 7 15 4 23 21 1 0.124 0.956 1.000 271 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(1), ACADM(1), ALDH1A3(3), ALDH1B1(1), ALDH2(2), ALDH7A1(1), AOC2(3), AOC3(1), CNDP1(3), DPYD(4), DPYS(2), ECHS1(2), EHHADH(5), GAD2(1), HADHA(2), MLYCD(2), SMS(2), UPB1(1) 17467757 37 33 34 6 2 4 10 7 14 0 0.0761 0.958 1.000 272 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 CCL2(1), LDLR(1), LPL(2) 3413036 4 4 4 2 0 2 0 1 1 0 0.732 0.958 1.000 273 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F2(2), F5(7), F7(1), FGA(2), FGB(1), FGG(5), PROC(3), PROS1(4), TFPI(1) 10725276 26 25 24 6 1 1 1 10 12 1 0.562 0.959 1.000 274 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 LDLR(1), NR1H3(2), NR1H4(2) 3365546 5 5 5 2 0 2 0 2 1 0 0.733 0.959 1.000 275 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 DPM2(1), EGR1(9), HRAS(1), MAPK3(1), NGFR(1), RAF1(1) 5216259 14 14 7 4 2 1 0 3 8 0 0.881 0.959 1.000 276 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(2), ICAM1(1), ITGA4(2), ITGAL(5), ITGAM(5), ITGB1(4), ITGB2(1), SELE(4), SELP(2) 10666870 26 24 26 6 0 7 4 7 8 0 0.322 0.960 1.000 277 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(1), AOC2(3), AOC3(1), CES1(7), DDHD1(2), ESCO1(2), ESCO2(1), PLA1A(3), PNPLA3(2), SH3GLB1(2) 16430976 24 22 22 2 1 2 1 8 12 0 0.160 0.961 1.000 278 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(1), B4GALT3(2), B4GALT5(1), ST3GAL1(1), ST3GAL3(3), ST3GAL4(1) 5027823 9 9 8 5 1 0 1 1 6 0 0.970 0.963 1.000 279 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(3), DHCR7(2), FDFT1(2), FDPS(1), GGCX(1), IDI1(1), IDI2(1), LSS(2), MVK(1), NSDHL(3), PMVK(1), TM7SF2(1), VKORC1(1) 12617987 20 18 18 2 0 2 1 8 9 0 0.332 0.966 1.000 280 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(7), CD38(1), ENPP3(1), NADSYN1(1), NMNAT2(2), NMNAT3(2), NNMT(1), NNT(6), NT5C1B(1), NT5C2(1), NT5M(2), NUDT12(2), QPRT(1) 14178712 28 27 28 5 1 3 4 13 7 0 0.294 0.967 1.000 281 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 12 AKT1(1), CAT(2), GHR(1), HRAS(1), IGF1R(1), PIK3CA(10), PIK3R1(2), SHC1(3) 8559038 21 20 18 5 2 6 2 8 3 0 0.365 0.969 1.000 282 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 AKT1(1), DPM2(1), GRB2(2), HRAS(1), NTRK1(5), PIK3CA(10), PIK3R1(2), PLCG1(2), PRKCA(2), SHC1(3), SOS1(5) 10114817 34 33 29 8 1 10 2 14 7 0 0.447 0.970 1.000 283 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(15), CDC25A(1), CDC25B(1), CDC25C(2), MYT1(2), WEE1(1) 9173713 22 19 22 5 0 3 2 9 8 0 0.561 0.971 1.000 284 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACADM(1), ACADS(3), ACOX1(1), ACOX3(2), ACSL1(2), ACSL3(13), ACSL4(1), ACSL5(1), ACSL6(4), ADH1A(2), ADH1B(2), ADH4(1), ADH5(1), ADH6(1), ADHFE1(2), ALDH1A3(3), ALDH1B1(1), ALDH2(2), ALDH7A1(1), CPT1A(1), CPT1C(4), CPT2(1), CYP4A11(4), ECHS1(2), EHHADH(5), GCDH(3), HADH(1), HADHA(2), HADHB(3) 32352413 70 57 51 10 5 7 11 25 22 0 0.0355 0.972 1.000 285 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS2(1), DHRSX(5), ESCO1(2), ESCO2(1), PNPLA3(2), SH3GLB1(2) 10831774 13 13 9 0 0 1 1 3 8 0 0.266 0.973 1.000 286 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 APC(7), AXIN1(2), BTRC(2), CTNNB1(1), DLL1(1), DVL1(1), FZD1(1), GSK3B(3), NOTCH1(5) 12978526 23 22 20 4 1 3 3 10 6 0 0.269 0.974 1.000 287 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD9(1), ADH1A(2), ADH1B(2), ADH4(1), ADH5(1), ADH6(1), ADHFE1(2), DHRS2(1), DHRSX(5), ESCO1(2), ESCO2(1), PNPLA3(2), SH3GLB1(2) 16469964 23 20 18 2 1 1 1 9 11 0 0.365 0.974 1.000 288 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AADAT(1), AASDH(3), AASDHPPT(2), AASS(4), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH2(2), BBOX1(1), DOT1L(2), ECHS1(2), EHHADH(5), EHMT1(3), EHMT2(3), GCDH(3), HADHA(2), PLOD1(2), PLOD2(4), PLOD3(11), SHMT1(2), SHMT2(3), TMLHE(1) 23315967 62 50 50 9 4 10 6 14 27 1 0.123 0.974 1.000 289 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 NFKB1(1), PLCB1(1), PRKCA(2), RELA(5) 5442041 9 9 6 4 0 3 0 0 5 1 0.927 0.975 1.000 290 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(2), IFNB1(2), JAK1(4), PTPRU(4), STAT1(3), STAT2(6), TYK2(6) 8016205 27 23 26 7 3 4 3 8 9 0 0.459 0.975 1.000 291 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 DPM2(1), ELK1(1), FOS(1), GRB2(2), HRAS(1), JUN(2), MAPK3(1), NGFR(1), PIK3CA(10), PIK3R1(2), PLCG1(2), RAF1(1), SHC1(3), SOS1(5) 12245002 33 32 29 7 3 9 2 14 5 0 0.332 0.975 1.000 292 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 DPM2(1), EGFR(9), ELK1(1), GNAS(5), GNB1(2), GRB2(2), HRAS(1), IGF1R(1), ITGB1(4), MAPK3(1), MKNK1(2), MKNK2(1), NGFR(1), PDGFRA(5), PPP2CA(1), PTPRR(3), RAF1(1), RPS6KA1(7), RPS6KA5(1), SHC1(3), SOS1(5), SRC(1), STAT3(3) 21388019 61 51 55 12 7 10 5 22 16 1 0.259 0.977 1.000 293 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(4), CS(2), DLD(2), IDH1(2), IDH2(5), IDH3B(1), IDH3G(2), MDH1(1), PC(3), PCK1(4), SDHA(1), SDHB(1), SUCLA2(1), SUCLG1(5), SUCLG2(2) 13517464 36 32 33 8 2 3 5 15 11 0 0.460 0.977 1.000 294 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CYP11A1(1), CYP11B2(2), CYP17A1(1), HSD3B1(1) 4396277 5 5 5 2 0 0 1 4 0 0 0.741 0.977 1.000 295 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 CAD(9), CANT1(1), DCTD(1), DPYD(4), DPYS(2), DTYMK(1), NT5M(2), POLB(1), POLD1(6), POLE(4), POLG(4), POLL(2), POLQ(9), POLR1B(2), POLR2A(8), POLR2B(4), POLR2F(3), POLR2I(1), POLRMT(2), RRM1(2), RRM2(1), TK1(1), TK2(1), UCK1(1), UCK2(1), UMPS(1), UNG(1), UPB1(1) 37263633 76 58 68 10 3 10 10 20 32 1 0.0222 0.977 1.000 296 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(4), JAK2(5), JAK3(3), MAPK3(1), STAT3(3), TYK2(6) 7595297 22 22 21 9 1 0 4 8 9 0 0.962 0.978 1.000 297 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 ELK1(1), FOS(1), GRB2(2), HRAS(1), JAK1(4), JUN(2), MAP3K1(5), MAPK3(1), PDGFRA(5), PIK3CA(10), PIK3R1(2), PLCG1(2), PRKCA(2), RAF1(1), RASA1(3), SHC1(3), SOS1(5), STAT1(3), STAT3(3), STAT5A(2) 22937485 58 55 53 10 4 12 4 21 17 0 0.154 0.979 1.000 298 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 92 AKT1(1), AKT2(3), AKT3(1), BCL10(1), CARD11(8), CBL(2), CBLB(2), CBLC(1), CD28(1), CD3E(1), CD3G(2), CD4(10), CD8A(1), CDC42(1), CDK4(6), CHUK(1), CTLA4(1), FOS(1), FYN(2), GRAP2(1), GRB2(2), HRAS(1), ICOS(2), IKBKB(1), IL4(1), ITK(1), JUN(2), KRAS(1), LCP2(1), MALT1(1), NCK1(1), NFAT5(6), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), NFKB1(1), NFKB2(1), NFKBIB(1), PAK1(2), PAK2(2), PAK4(2), PAK6(4), PAK7(2), PDK1(1), PIK3CA(10), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PLCG1(2), PPP3CA(2), PPP3CC(3), PRKCQ(4), PTPN6(3), PTPRC(6), RASGRP1(2), SOS1(5), SOS2(3), TEC(5), VAV1(3), VAV2(4) 65780591 164 115 146 22 7 24 18 64 50 1 0.00598 0.980 1.000 299 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CD2(2), CD3E(1), CD3G(2), CD4(10), IL12RB1(2), IL12RB2(2), JAK2(5), STAT4(1), TYK2(6) 9673965 31 29 24 7 2 1 3 10 14 1 0.840 0.980 1.000 300 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ALDH1A3(3), ALDH1B1(1), ALDH2(2), ALDH3B1(3), ALDH3B2(2), ALDH7A1(1), AMDHD1(1), AOC2(3), AOC3(1), ASPA(1), CNDP1(3), DDC(2), FTCD(2), HAL(1), HARS(1), HARS2(1), HNMT(1), LCMT1(1), LCMT2(3), MAOA(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(3), PRPS1(1), PRPS2(3), UROC1(1) 25522496 47 42 44 5 2 10 7 14 14 0 0.0127 0.981 1.000 301 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP1(1), ACP2(1), ACP5(2), ACP6(1), ALPI(2), ALPL(2), ALPP(3), ALPPL2(3), CYP3A7(1), DHRS2(1), DHRSX(5), PON3(4) 11460846 26 25 21 5 1 5 2 9 9 0 0.399 0.982 1.000 302 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 AKT1(1), GRB2(2), HRAS(1), IGF1R(1), IRS1(4), MAPK3(1), PIK3CA(10), PIK3R1(2), RAF1(1), SHC1(3), SOS1(5) 12073442 31 29 28 7 5 9 2 12 3 0 0.211 0.983 1.000 303 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 GNB1(2), HTR2C(1), PLCB1(1), TUB(1) 4682284 5 5 5 2 0 0 0 4 1 0 0.848 0.984 1.000 304 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARSA(1), GOT1(3), GOT2(2), PAH(3), TAT(1), YARS(1) 5743651 11 11 11 4 1 0 2 3 5 0 0.877 0.984 1.000 305 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 AKR1B1(3), GUSB(5), RPE(1), UGP2(1), UGT1A1(3), UGT1A4(2), UGT1A5(1), UGT1A6(3), UGT1A7(3), UGT2A1(3), UGT2A3(2), UGT2B11(2), UGT2B15(1), UGT2B28(3), UGT2B4(2), UGT2B7(3), XYLB(1) 17938184 39 35 39 7 3 6 6 12 12 0 0.221 0.984 1.000 306 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 MTMR1(1), MTMR2(1), NFS1(1), THTPA(1) 4262104 4 4 4 2 1 0 1 2 0 0 0.826 0.984 1.000 307 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(1), FUCA2(1), GLB1(5), HEXA(3), LCT(2), MAN2B2(2), MAN2C1(5), MANBA(1), NEU1(1) 12702405 21 19 21 4 1 3 3 11 3 0 0.276 0.985 1.000 308 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX12(2), ALOX15B(2), ALOX5(2), DPEP1(1), GGT1(2), LTA4H(4), PLA2G6(2), PTGDS(1), PTGS1(2), PTGS2(4), TBXAS1(3) 9760650 25 22 23 6 2 4 6 5 7 1 0.410 0.985 1.000 309 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 42 CALM2(1), CD3E(1), CD3G(2), ELK1(1), FOS(1), FYN(2), GRB2(2), HRAS(1), JUN(2), MAP3K1(5), MAPK3(1), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), NFKB1(1), PIK3CA(10), PIK3R1(2), PLCG1(2), PPP3CA(2), PPP3CC(3), PRKCA(2), PTPN7(1), RAF1(1), RASA1(3), RELA(5), SHC1(3), SOS1(5), SYT1(1), VAV1(3) 30766912 78 70 69 14 6 18 6 23 24 1 0.102 0.985 1.000 310 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOA(1), ALDOB(3), GOT1(3), GOT2(2), GPT(2), GPT2(2), MDH1(1), ME1(1), ME2(2), ME3(2), PGK1(3), RPE(1), TKT(1), TPI1(1) 11637287 25 23 25 6 0 3 5 5 12 0 0.590 0.986 1.000 311 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 CASP8(1), MAP3K1(5), MAPK3(1), NFKB1(1), NSMAF(3), RAF1(1), RELA(5), RIPK1(1), TNFRSF1A(1), TRADD(2), TRAF2(1) 13355727 22 19 19 4 1 4 3 4 9 1 0.260 0.986 1.000 312 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 66 A2M(5), BDKRB1(1), BDKRB2(1), C1QA(1), C1QC(1), C1R(3), C1S(16), C2(4), C3(6), C3AR1(1), C4BPA(3), C4BPB(2), C5(5), C5AR1(2), C6(1), C7(3), C8A(1), C8B(1), C8G(1), CD55(1), CFB(2), CFH(4), CFI(1), CPB2(5), CR1(7), CR2(2), F11(1), F12(3), F13A1(1), F13B(2), F2(2), F5(7), F7(1), F8(5), F9(2), FGA(2), FGB(1), FGG(5), KLKB1(2), KNG1(2), MASP1(2), MASP2(1), MBL2(1), PLAT(4), PLAUR(2), PLG(5), PROC(3), PROS1(4), SERPINA1(2), SERPIND1(2), SERPINF2(2), SERPING1(2), TFPI(1), VWF(11) 58915164 158 109 137 27 13 18 15 67 42 3 0.0101 0.987 1.000 313 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 JAK1(4), JAK2(5), JAK3(3), PIAS1(4), PIAS3(2), PTPRU(4), SOAT1(4) 8989340 26 22 24 6 1 1 5 9 10 0 0.455 0.987 1.000 314 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP1(1), ACP2(1), ACP5(2), ENPP3(1), FLAD1(2), TYR(5) 6339264 12 12 12 4 0 3 0 6 3 0 0.770 0.988 1.000 315 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARF1(1), ARFGEF2(6), CLTB(1), COPA(6), GBF1(6), GPLD1(1), KDELR3(2) 10825705 23 22 23 5 1 1 2 11 7 1 0.604 0.988 1.000 316 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(2), GABRA2(1), GABRA3(1), GABRA4(1), GABRA5(1), PRKCE(2) 5231754 8 8 8 4 0 0 1 4 3 0 0.939 0.988 1.000 317 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(1), PLCG1(2), PRKCA(2), PTK2B(3) 4390874 8 8 7 5 0 3 0 1 4 0 0.959 0.989 1.000 318 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 24 ATM(15), BMPR1B(1), CCND2(1), CDK4(6), EGR1(9), ESR2(2), FSHR(2), MLH1(2), NCOR1(4), NRIP1(4), PGR(2), PRLR(2), PTGER2(1), VDR(1), ZP2(2) 22374800 54 46 44 8 4 7 5 13 25 0 0.172 0.990 1.000 319 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(1), HMOX1(2), JAK1(4), STAT1(3), STAT3(3), STAT5A(2) 7906947 15 15 14 4 1 0 1 5 8 0 0.882 0.990 1.000 320 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(1), CTH(1), GGT1(2), LCMT1(1), LCMT2(3), MARS(2), MARS2(3), PAPSS1(2), PAPSS2(2), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(3), SCLY(2), SEPHS1(1), SEPHS2(2) 15925758 30 29 30 5 3 2 8 9 8 0 0.200 0.991 1.000 321 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 B3GNT1(1), B3GNT2(3), B3GNT3(1), B3GNT5(1), B4GALT3(2), B4GALT4(2), FUT6(2), GCNT2(2), ST8SIA1(2) 9677693 16 15 16 4 2 4 3 3 4 0 0.423 0.991 1.000 322 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOA(1), ALDOB(3), GOT1(3), GOT2(2), GPT(2), GPT2(2), MDH1(1), ME1(1), ME3(2), PGK1(3), RPE(1), TKT(1), TKTL1(1), TKTL2(2), TPI1(1) 13036866 26 25 26 7 0 2 5 6 13 0 0.736 0.992 1.000 323 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 11 ALAS1(5), ALAS2(3), CPO(1), FECH(2), GATA1(1), HBB(3), UROD(1) 5212363 16 16 14 5 0 1 3 9 3 0 0.698 0.992 1.000 324 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 DLL1(1), FURIN(3), NOTCH1(5) 5218392 9 9 7 3 1 1 0 3 4 0 0.883 0.992 1.000 325 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 CAPN1(1), CAPN2(2), EGF(4), EGFR(9), HRAS(1), ITGA1(5), ITGB1(4), MAPK3(1), MYL2(1), MYLK(4), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2), PTK2(1), PXN(1), TLN1(6) 21454073 48 43 45 9 8 4 3 17 16 0 0.246 0.993 1.000 326 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ERBB4(6), NRG2(2), NRG3(2), PRKCA(2) 6056416 12 12 12 4 1 3 1 5 2 0 0.681 0.993 1.000 327 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(2), CALCR(2), CALCRL(1), CD97(4), CRHR1(1), CRHR2(2), ELTD1(2), EMR1(2), EMR2(2), GIPR(1), GLP1R(1), GLP2R(2), GPR64(2), LPHN1(2), LPHN2(3), LPHN3(8), SCTR(1), VIPR1(1) 18037113 39 33 39 8 6 5 4 16 8 0 0.164 0.994 1.000 328 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT1(1), B3GNT2(3), B3GNT7(1), B4GALT3(2), B4GALT4(2), CHST1(2), CHST2(1), CHST4(1), ST3GAL1(1), ST3GAL3(3), ST3GAL4(1) 7451397 18 17 17 5 1 3 2 3 9 0 0.703 0.994 1.000 329 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 AGXT(1), AKR1B10(2), ALAS1(5), ALAS2(3), AOC2(3), AOC3(1), BHMT(2), CHDH(2), CHKB(2), CTH(1), DAO(1), DLD(2), DMGDH(4), GATM(1), GLDC(3), GNMT(1), MAOA(1), PHGDH(3), PISD(1), PSAT1(1), RDH11(3), SARDH(3), SARS(2), SHMT1(2), SHMT2(3), TARS(5), TARS2(5) 27800539 63 56 59 11 8 9 10 18 18 0 0.0416 0.994 1.000 330 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(3), CLOCK(1), PER1(4), PER2(4), PER3(3) 11025602 15 15 13 3 0 1 4 5 5 0 0.441 0.995 1.000 331 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH2(2) 5203296 8 8 6 4 0 1 1 2 4 0 0.963 0.995 1.000 332 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH2(2) 5203296 8 8 6 4 0 1 1 2 4 0 0.963 0.995 1.000 333 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(3), CYP2A13(3), NAT1(1), NAT2(1), XDH(5) 5170152 13 13 13 5 2 1 2 4 4 0 0.860 0.995 1.000 334 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAD9(1), ADH1A(2), ADH1B(2), ADH4(1), ADH5(1), ADH6(1), ADHFE1(2), AKR1B10(2), ALDH1A3(3), ALDH1B1(1), ALDH2(2), ALDH7A1(1), BAAT(1), CEL(1), CYP27A1(1), HADHB(3), RDH11(3), SLC27A5(2), SOAT1(4), SOAT2(2) 20802444 36 33 31 5 4 2 3 14 13 0 0.184 0.995 1.000 335 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(1), LDLR(1), MBTPS1(2), SCAP(1), SREBF1(2), SREBF2(6) 7505675 13 13 13 4 1 3 2 2 5 0 0.681 0.995 1.000 336 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(2), CHIA(3), CHIT1(4), CYB5R1(2), CYB5R3(2), GFPT2(1), GNE(1), GNPDA1(1), HEXA(3), HK1(5), MTMR1(1), MTMR2(1), NAGK(2), NANS(2), NPL(5), RENBP(2) 18875362 37 34 34 6 4 4 5 11 13 0 0.0701 0.996 1.000 337 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 34 ACTG1(3), ACTG2(1), ACTR2(1), AKT1(1), CDC42(1), CFL1(1), FLNA(4), FLNC(5), FSCN1(3), FSCN3(2), GDI2(1), LIMK1(4), MYH2(9), MYLK(4), MYLK2(1), PAK1(2), PAK2(2), PAK4(2), PAK6(4), PAK7(2), RHO(1), ROCK1(4), ROCK2(2), WASL(6) 30169321 66 54 64 11 4 9 2 20 31 0 0.143 0.996 1.000 338 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 15 B3GAT1(2), B3GAT2(1), B3GAT3(1), CHST11(1), CHST12(2), CHST14(1), CHST7(1), CHSY1(8), DSE(1), XYLT1(2), XYLT2(2) 7901368 22 20 16 5 2 5 0 5 10 0 0.517 0.996 1.000 339 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA2A(1), ADORA2B(1), P2RY1(1), P2RY2(1) 3573278 4 4 4 5 0 1 0 2 1 0 0.974 0.996 1.000 340 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1R(4), DDX20(4), E2F1(1), ETS1(1), ETS2(1), FOS(1), HRAS(1), JUN(2), NCOR2(6), RBL2(2), SIN3A(1), SIN3B(1) 16981032 25 23 25 4 2 2 1 10 10 0 0.324 0.996 1.000 341 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 AKT1(1), BDKRB2(1), CALM2(1), CHRNA1(2), FLT1(7), FLT4(7), KDR(5), NOS3(2), PDE2A(1), PDE3A(3), PDE3B(1), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2), PRKG1(3), PRKG2(2), RYR2(11), SLC7A1(1), SYT1(1), TNNI1(2) 26966845 59 55 59 10 10 10 6 19 14 0 0.0382 0.996 1.000 342 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH2(2), ALDH3B1(3), ALDH3B2(2), AOC2(3), AOC3(1), ASPA(1), CNDP1(3), DDC(2), HAL(1), HARS(1), HNMT(1), MAOA(1), PRPS1(1), PRPS2(3) 15828919 31 30 28 6 1 6 6 8 10 0 0.207 0.996 1.000 343 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(7), AXIN1(2), CREBBP(5), CTNNB1(1), DVL1(1), EP300(11), FZD1(1), GSK3B(3), HDAC1(2), LDB1(1), LEF1(1), PITX2(2), TRRAP(8) 21404191 45 39 37 6 1 2 8 17 17 0 0.0964 0.997 1.000 344 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 CS(2), IDH2(5), MDH1(1), OGDH(3), SDHA(1), SUCLA2(1) 6227804 13 12 10 5 0 3 0 5 5 0 0.906 0.997 1.000 345 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 55 ADH1A(2), ADH1B(2), ADH4(1), ADH5(1), ADH6(1), ADHFE1(2), ALDH1A3(3), ALDH3B1(3), ALDH3B2(2), AOC2(3), AOC3(1), AOX1(7), DBH(2), DCT(4), DDC(2), ECH1(2), ESCO1(2), ESCO2(1), FAH(1), GOT1(3), GOT2(2), HGD(2), LCMT1(1), LCMT2(3), MAOA(1), PNPLA3(2), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(3), SH3GLB1(2), TAT(1), TH(2), TPO(4), TYR(5), TYRP1(1) 38483713 79 66 75 12 6 7 10 29 27 0 0.0859 0.997 1.000 346 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CALM2(1), CHUK(1), EGR2(1), EGR3(1), MAP3K1(5), NFATC1(2), NFATC2(5), NFKB1(1), PLCG1(2), PPP3CA(2), PPP3CC(3), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2), RELA(5), SYT1(1) 17766085 38 34 32 6 4 5 0 10 18 1 0.250 0.997 1.000 347 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 84 ANPEP(5), CD19(1), CD1A(1), CD1B(1), CD1C(1), CD1D(2), CD1E(2), CD2(2), CD22(4), CD33(1), CD34(2), CD38(1), CD3E(1), CD3G(2), CD4(10), CD44(2), CD55(1), CD8A(1), CR1(7), CR2(2), CSF1R(4), CSF2RA(2), CSF3R(2), DNTT(4), FLT3(6), HLA-DRA(1), HLA-DRB1(1), IL11RA(1), IL1B(1), IL1R1(1), IL1R2(4), IL2RA(2), IL3(1), IL4(1), IL4R(2), IL6R(2), IL9R(2), ITGA1(5), ITGA2(2), ITGA3(3), ITGA4(2), ITGA5(3), ITGA6(4), ITGAM(5), ITGB3(1), KITLG(2), MME(5), MS4A1(1), TFRC(2), TPO(4) 53253971 125 85 111 22 6 11 13 39 55 1 0.249 0.997 1.000 348 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 15 AKT1(1), EGFR(9), IGF1R(1), POLR2A(8), PPP2CA(1), PRKCA(2), RB1(2), TEP1(4), TERT(5), TNKS(4), TP53(15), XRCC5(3) 18382141 55 42 51 12 7 10 5 13 18 2 0.142 0.997 1.000 349 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 PLCD1(1), PRKCA(2) 3139352 3 3 3 2 0 1 0 1 1 0 0.914 0.998 1.000 350 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 26 ALDH1A3(3), ALDH3B1(3), ALDH3B2(2), AOC2(3), AOC3(1), DDC(2), EPX(2), ESCO1(2), ESCO2(1), GOT1(3), GOT2(2), MAOA(1), MPO(4), PNPLA3(2), SH3GLB1(2), TAT(1), TPO(4) 22080165 38 35 35 5 2 4 7 9 16 0 0.108 0.998 1.000 351 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(2), ARHGEF1(2), F2(2), GNA12(1), GNA13(4), GNAI1(1), GNB1(2), MAP3K7(1), PIK3CA(10), PIK3R1(2), PLCB1(1), PPP1R12B(1), PRKCA(2), PTK2B(3), ROCK1(4) 16828076 38 37 35 8 2 8 2 18 8 0 0.243 0.998 1.000 352 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 AKT1(1), CABIN1(7), CALM2(1), CAMK1(1), CAMK1G(3), IGF1R(1), INSR(4), MAPK14(1), MAPK7(1), MEF2D(1), NFATC1(2), NFATC2(5), PIK3CA(10), PIK3R1(2), PPP3CA(2), PPP3CC(3), SYT1(1) 22207763 46 42 38 8 4 9 3 14 16 0 0.124 0.998 1.000 353 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 ASAH1(1), BRAF(2), CREB5(2), RAF1(1), SNX13(2), SRC(1) 7645801 9 6 9 3 0 3 1 4 0 1 0.687 0.998 1.000 354 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 IL6R(2), JAK1(4), JAK2(5), JAK3(3), PIAS3(2), PTPRU(4), SRC(1), STAT3(3) 9856128 24 21 24 9 1 2 3 9 9 0 0.920 0.998 1.000 355 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 84 ATF2(1), BRAF(2), CHUK(1), DAXX(5), ELK1(1), FOS(1), GRB2(2), HRAS(1), IKBKB(1), JUN(2), MAP2K3(2), MAP2K5(1), MAP2K7(1), MAP3K1(5), MAP3K10(3), MAP3K11(1), MAP3K12(4), MAP3K13(2), MAP3K2(2), MAP3K3(2), MAP3K4(5), MAP3K5(5), MAP3K6(2), MAP3K7(1), MAP3K9(3), MAP4K1(1), MAP4K3(4), MAP4K4(2), MAP4K5(4), MAPK10(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK4(1), MAPK7(1), MAPK9(2), MAPKAPK2(1), MAX(5), MEF2D(1), MKNK1(2), MKNK2(1), NFKB1(1), PAK1(2), PAK2(2), RAF1(1), RELA(5), RIPK1(1), RPS6KA1(7), RPS6KA4(1), RPS6KA5(1), RPS6KB1(2), RPS6KB2(2), SHC1(3), SP1(2), STAT1(3), TGFB2(1), TRADD(2), TRAF2(1) 62711428 123 88 114 16 14 13 7 43 43 3 0.0113 0.998 1.000 356 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AADAT(1), AASDHPPT(2), AASS(4), AKR1B10(2), ALDH1A3(3), ALDH1B1(1), ALDH2(2), ALDH7A1(1), BBOX1(1), DOT1L(2), ECHS1(2), EHHADH(5), EHMT1(3), EHMT2(3), GCDH(3), HADH(1), HADHA(2), NSD1(8), OGDH(3), OGDHL(2), PLOD1(2), PLOD2(4), PLOD3(11), RDH11(3), SETD1A(4), SETD7(1), SETDB1(4), SHMT1(2), SHMT2(3), SPCS1(1), SUV39H2(4), TMLHE(1) 37046209 91 69 78 17 6 15 11 23 35 1 0.174 0.998 1.000 357 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ALDH1A3(3), ALDH1B1(1), ALDH2(2), ALDH7A1(1), CYP2C19(1), DHRS2(1), DHRSX(5), ECHS1(2), EHHADH(5), ESCO1(2), ESCO2(1), HADHA(2), PNPLA3(2), SH3GLB1(2), YOD1(1) 20234780 31 28 24 4 1 5 3 6 16 0 0.260 0.998 1.000 358 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(6), ACO1(4), CLYBL(2), CS(2), DLD(2), IDH1(2), IDH2(5), IDH3B(1), IDH3G(2), MDH1(1), OGDH(3), OGDHL(2), PC(3), PCK1(4), PCK2(1), SDHA(1), SDHB(1), SDHD(1), SUCLA2(1), SUCLG1(5), SUCLG2(2) 19614320 51 44 48 11 3 7 5 21 15 0 0.349 0.999 1.000 359 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(1), ST3GAL1(1), ST3GAL4(1), ST3GAL5(1), ST6GALNAC2(2), ST8SIA1(2) 3499094 8 8 8 4 0 2 1 4 1 0 0.742 0.999 1.000 360 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(1), COASY(1), DPYD(4), DPYS(2), ENPP3(1), PANK1(2), PANK2(4), PANK3(1), PANK4(1), UPB1(1) 9047276 18 17 18 5 1 2 3 7 5 0 0.554 0.999 1.000 361 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2B(1), CAMK2D(1), CAMK2G(2), ITPKB(2), ITPR1(4), ITPR2(9), ITPR3(4), NFAT5(6), PDE6A(1), PDE6B(3), PDE6C(2), SLC6A13(2) 23627157 37 34 37 6 5 4 7 14 7 0 0.0867 0.999 1.000 362 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 AKT1(1), PIK3CA(10), PIK3R1(2), PLCB1(1), PLCG1(2), PRKCA(2), VAV1(3) 8540621 21 21 17 8 1 7 2 5 6 0 0.732 0.999 1.000 363 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 41 APAF1(2), BID(1), BIRC2(2), BIRC3(2), CASP2(1), CASP7(1), CASP8(1), CASP9(1), FAS(1), JUN(2), MAP3K1(5), MAPK10(1), NFKB1(1), PARP1(3), PRF1(1), RELA(5), RIPK1(1), TNFRSF1A(1), TNFSF10(6), TP53(15), TRADD(2), TRAF2(1) 24064447 56 43 48 11 1 10 6 15 21 3 0.204 0.999 1.000 364 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT1(1), AKT2(3), AKT3(1), GRB2(2), IARS(4), IL13RA1(1), IL4(1), IL4R(2), INPP5D(2), JAK1(4), JAK2(5), JAK3(3), PIK3CA(10), PPP1R13B(3), RPS6KB1(2), SHC1(3), SOS1(5), SOS2(3), SRC(1), STAT6(4), TYK2(6) 23899296 66 56 62 13 2 13 12 23 16 0 0.156 0.999 1.000 365 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(1), ACADM(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH2(2), AOC2(3), AOC3(1), CNDP1(3), DPYD(4), DPYS(2), ECHS1(2), EHHADH(5), GAD2(1), HADHA(2), MLYCD(2), SMS(2), UPB1(1) 18839524 38 34 35 8 2 4 11 8 13 0 0.178 0.999 1.000 366 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 19 ABL1(4), ATM(15), BRCA1(5), CDKN1A(1), CHEK2(1), JUN(2), MRE11A(1), NFKB1(1), RAD50(4), RAD51(2), RELA(5), TP53(15), TP73(3) 19442110 59 50 54 11 2 10 5 19 20 3 0.282 0.999 1.000 367 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(7), CDH1(1), CREBBP(5), EP300(11), MAP3K7(1), MAPK3(1), SKIL(1), TGFB2(1), TGFBR2(1) 16947697 29 27 26 5 2 2 7 10 8 0 0.148 0.999 1.000 368 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 BDH1(1), BDH2(1), HMGCS1(1), HMGCS2(1), OXCT1(1) 4779260 5 5 5 3 0 1 0 3 1 0 0.950 0.999 1.000 369 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 ACVR1(1), APC(7), ATF2(1), AXIN1(2), BMP10(1), BMP2(1), BMP4(1), BMP5(1), BMP7(3), BMPR2(5), CHRD(3), CTNNB1(1), DVL1(1), FZD1(1), GATA4(2), GSK3B(3), MAP3K7(1), MYL2(1), NPPA(1), NPPB(1), RFC1(4), TGFB2(1), TGFBR2(1), TGFBR3(3) 23282567 47 41 45 7 4 5 4 20 14 0 0.0720 0.999 1.000 370 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 ALOX12(2), ALOX5(2), CBR1(2), CYP4F2(2), EPX(2), GGT1(2), LTA4H(4), MPO(4), PLA2G4A(1), PLA2G6(2), PRDX1(1), PRDX5(1), PTGDS(1), PTGS1(2), PTGS2(4), TBXAS1(3), TPO(4) 17956538 39 36 37 8 3 6 9 10 10 1 0.207 0.999 1.000 371 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 ACHE(1), CHAT(4), DBH(2), DDC(2), GAD2(1), MAOA(1), PAH(3), SLC18A3(1), TH(2), TPH1(1) 8959575 18 17 16 7 1 3 3 4 7 0 0.873 0.999 1.000 372 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGT(1), AGTR1(2), ATF2(1), CALM2(1), EGFR(9), ELK1(1), GRB2(2), HRAS(1), JUN(2), MAP3K1(5), MAPK3(1), MEF2D(1), PAK1(2), PRKCA(2), PTK2(1), PTK2B(3), RAF1(1), SHC1(3), SOS1(5), SRC(1), SYT1(1) 22267611 46 39 44 9 6 11 4 15 10 0 0.207 0.999 1.000 373 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 CREBBP(5), EP300(11), FYN(2), JAK1(4), JAK3(3), PIK3CA(10), PIK3R1(2), PTK2B(3), STAT5A(2), STAT5B(2) 18354788 44 39 37 9 1 8 8 14 13 0 0.224 0.999 1.000 374 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(2), AARS2(2), ABAT(1), ADSL(1), ADSSL1(1), AGXT(1), ASL(4), ASNS(1), ASPA(1), ASRGL1(4), ASS1(2), CAD(9), CRAT(1), DARS(1), DARS2(1), DLAT(2), DLD(2), GAD2(1), GOT1(3), GOT2(2), GPT(2), GPT2(2), NARS2(4), PC(3), PDHA1(1), PDHA2(2), PDHB(1) 24693317 57 44 50 10 2 5 11 13 25 1 0.175 0.999 1.000 375 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA3(2), PSMA4(2), PSMA6(3), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(1), PSMC2(1), PSMD1(1), PSMD11(3), PSMD13(2), PSMD2(5), PSMD6(1) 10694207 24 21 23 6 1 3 3 6 11 0 0.624 0.999 1.000 376 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(2), BCL2A1(2), CASP1(2), CASP10(2), CASP2(1), CASP7(1), CASP8(1), CASP9(1), DAXX(5), DFFB(1), FAS(1), IKBKE(1), LTA(1), NFKB1(1), NGFR(1), NTRK1(5), PTPN13(7), RIPK1(1), TFG(2), TNFRSF1A(1), TRADD(2), TRAF2(1), TRAF3(1), TRAF6(2) 28439569 45 40 44 7 3 8 3 22 9 0 0.101 0.999 1.000 377 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 59 CAD(9), CASP10(2), CASP8(1), CSNK1A1(2), DAXX(5), DEDD(1), EGFR(9), EPHB2(2), FAF1(1), FAIM2(1), MAP2K7(1), MAP3K1(5), MAP3K5(5), MAPK10(1), MAPK8IP1(3), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2), MET(6), NFAT5(6), NFKB1(1), NFKB2(1), NFKBIB(1), NFKBIL1(1), PTPN13(7), RALBP1(1), RIPK1(1), ROCK1(4), TP53(15), TPX2(1), TRAF2(1) 47567384 98 79 89 15 10 8 7 40 30 3 0.0438 0.999 1.000 378 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 12 FOS(1), JUN(2), KEAP1(2), MAPK14(1), NFE2L2(7), PRKCA(2) 5598849 15 15 15 6 1 3 2 7 2 0 0.768 0.999 1.000 379 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 33 GTF2A1(1), GTF2E1(1), GTF2E2(2), GTF2F1(1), GTF2F2(1), GTF2H1(2), GTF2H2(1), GTF2I(3), GTF2IRD1(1), STON1(2), TAF1(5), TAF1L(6), TAF2(5), TAF4(5), TAF4B(5), TAF5(2), TAF5L(2), TAF6(1), TAF7(1), TAF7L(5), TAF9B(1) 23845446 53 47 49 10 4 7 6 18 18 0 0.157 0.999 1.000 380 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ADCY4(2), ADCY6(1), ADCY8(8), CACNA1A(5), CACNA1B(4), GNAS(5), GNB1(2), GNB3(2), GNG3(1), GRM4(3), ITPR3(4), KCNB1(1), PDE1A(1), PLCB2(2), PRKACA(1), PRKACB(2), PRKACG(2), SCNN1A(2), SCNN1B(2), SCNN1G(2), TAS1R2(3), TAS1R3(2), TAS2R13(1), TAS2R3(14), TAS2R38(2), TAS2R39(1), TAS2R42(1), TAS2R43(2), TAS2R46(1), TAS2R50(1), TAS2R60(1), TAS2R8(1), TAS2R9(2), TRPM5(1) 36868061 85 66 75 15 14 6 7 39 19 0 0.0813 0.999 1.000 381 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(1), SRP68(2), SRP72(2), SRP9(1) 5035886 6 6 6 3 0 2 0 3 1 0 0.825 0.999 1.000 382 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 GBGT1(2), GLA(1), HEXA(3), ST3GAL1(1), ST3GAL4(1), ST8SIA1(2) 6422822 10 10 10 4 0 2 1 5 2 0 0.646 0.999 1.000 383 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(6), APOBEC1(1), APOBEC3B(1), APOBEC4(1) 4821591 9 8 9 6 2 0 2 4 1 0 0.943 0.999 1.000 384 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(1), ATF1(2), CDC42(1), CREB5(2), DUSP10(1), EEF2K(1), EIF4E(1), ELK1(1), IL1R1(1), MAP2K3(2), MAP3K10(3), MAP3K4(5), MAP3K5(5), MAP3K7(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPKAPK2(1), MKNK1(2), MKNK2(1), NFKB1(1), NR2C2(1), TRAF6(2) 21858948 38 36 38 7 2 9 0 21 6 0 0.174 1.000 1.000 385 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(2), BIRC2(2), BIRC3(2), CASP10(2), CASP7(1), CASP8(1), CASP9(1), DFFB(1), PRF1(1), SCAP(1), SREBF1(2), SREBF2(6) 11618458 22 21 22 5 1 5 2 6 8 0 0.425 1.000 1.000 386 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(1), GTF2A1(1), GTF2E1(1), GTF2F1(1), NCOA1(2), NCOA2(9), NCOA3(5), NCOR2(6), POLR2A(8), RARA(4), TBP(1) 16358051 39 31 33 9 1 5 5 9 19 0 0.387 1.000 1.000 387 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(1), AKT1(1), AKT2(3), AKT3(1), ITPKB(2), ITPR1(4), ITPR2(9), ITPR3(4), NFKB1(1), NFKB2(1), NFKBIB(1), NFKBIL1(1), PDK1(1), PHKA2(3), PIK3CB(3), PITX2(2), PLD1(2), PLD2(5), PLD3(3) 28922609 48 38 46 7 6 9 8 14 11 0 0.0181 1.000 1.000 388 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 HK1(5) 6631308 5 4 5 5 2 0 0 1 2 0 0.972 1.000 1.000 389 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CHUK(1), ELK1(1), FOS(1), IKBKB(1), IRAK1(3), JUN(2), LY96(1), MAP2K3(2), MAP3K1(5), MAP3K7(1), MAPK14(1), NFKB1(1), RELA(5), TLR10(2), TLR2(2), TLR4(2), TLR6(1), TLR7(3), TLR9(1), TRAF6(2) 23441123 38 34 34 6 2 8 1 13 13 1 0.179 1.000 1.000 390 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(1), CALM2(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), F2(2), FYN(2), GNAI1(1), GNB1(2), GRB2(2), HRAS(1), JAK2(5), MAPK14(1), MAPK3(1), MAPT(3), MYLK(4), PLCG1(2), PRKCA(2), PTK2B(3), RAF1(1), SHC1(3), SOS1(5), STAT1(3), STAT3(3), STAT5A(2), SYT1(1) 27480771 55 48 53 10 4 9 6 21 15 0 0.187 1.000 1.000 391 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(1), PARK2(1), SNCAIP(2), UBE2E2(1) 4184639 5 5 5 3 0 3 1 0 1 0 0.829 1.000 1.000 392 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(1), POLB(1), POLD1(6), POLD3(1), POLE(4), POLE2(1), POLG(4), POLG2(4), POLH(4), POLI(3), POLK(3), POLL(2), POLM(3), POLQ(9), PRIM1(2), PRIM2(2), REV1(2), REV3L(12), RFC5(1) 27198763 65 52 59 12 4 4 3 32 22 0 0.341 1.000 1.000 393 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 ALDOA(1), GREB1(11), HSPB2(2), MTA1(1), MTA3(2) 6796750 17 16 15 6 0 1 2 10 4 0 0.895 1.000 1.000 394 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(2), ABAT(1), ADSL(1), AGXT(1), ASL(4), ASNS(1), ASPA(1), CAD(9), CRAT(1), DARS(1), GAD2(1), GOT1(3), GOT2(2), GPT(2), GPT2(2), PC(3) 16996699 35 31 31 7 1 3 9 4 17 1 0.420 1.000 1.000 395 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(2), ATP6V0A1(2), ATP6V0A4(1), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(2), ATP6V1B2(2), ATP6V1D(1), ATP6V1G1(1), SHMT1(2) 10060370 18 17 18 6 0 2 4 6 6 0 0.774 1.000 1.000 396 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(2), ATP6V0A1(2), ATP6V0A4(1), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(2), ATP6V1B2(2), ATP6V1D(1), ATP6V1G1(1), SHMT1(2) 10060370 18 17 18 6 0 2 4 6 6 0 0.774 1.000 1.000 397 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(2), ATP6V0A1(2), ATP6V0A4(1), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(2), ATP6V1B2(2), ATP6V1D(1), ATP6V1G1(1), SHMT1(2) 10060370 18 17 18 6 0 2 4 6 6 0 0.774 1.000 1.000 398 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(5), CD44(2), IL1B(1), IL6R(2), SPN(1), TGFB2(1), TNFRSF1A(1) 8490160 13 13 11 4 2 4 0 1 6 0 0.691 1.000 1.000 399 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(1), ACACA(6), ACACB(4), ACADM(1), ACSS1(2), ACSS2(7), ALDH1A3(3), ALDH1B1(1), ALDH2(2), ALDH7A1(1), ECHS1(2), EHHADH(5), HADHA(2), LDHAL6B(1), LDHB(1), LDHC(3), MCEE(1), MLYCD(2), MUT(2), PCCA(1), PCCB(3), SUCLA2(1), SUCLG1(5), SUCLG2(2) 26298582 59 49 54 12 3 7 15 13 20 1 0.198 1.000 1.000 400 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 HK1(5), IMPA2(3) 7466458 8 7 8 6 3 0 0 2 3 0 0.970 1.000 1.000 401 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(5), EP300(11), MAPK3(1), PELP1(1), SRC(1) 9572843 19 16 16 7 2 1 4 5 7 0 0.789 1.000 1.000 402 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(2), ALG5(1), B4GALT3(2), B4GALT5(1), DPAGT1(5), DPM1(1), MAN1A1(2), MGAT4A(3), MGAT4B(1), MGAT5(3), RPN1(2), RPN2(1) 12592340 24 24 24 7 0 6 0 9 9 0 0.645 1.000 1.000 403 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(8), CASP1(2), CASP7(1), CASP8(1), GAPDH(2), INSR(4), ITCH(1), MAGI1(3), MAGI2(4), RERE(4), WWP2(3) 15438477 33 29 24 8 5 2 3 8 13 2 0.788 1.000 1.000 404 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(2), BCL10(1), BID(1), CASP9(1), CES1(7) 7571865 12 12 10 4 0 1 0 6 5 0 0.867 1.000 1.000 405 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 ABAT(1), ACADS(3), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH2(2), ECHS1(2), EHHADH(5), GAD2(1), HADHA(2), L2HGDH(1), OXCT1(1), PDHA1(1), PDHA2(2), PDHB(1), SDHB(1) 16974815 29 28 25 6 4 5 6 5 9 0 0.227 1.000 1.000 406 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 21 ATM(15), ATR(7), BRCA1(5), BRCA2(7), CHEK2(1), FANCA(4), FANCE(2), FANCF(2), FANCG(3), HUS1(2), MRE11A(1), RAD17(1), RAD50(4), RAD51(2), TP53(15), TREX1(2) 29412454 73 61 71 12 3 13 7 27 21 2 0.134 1.000 1.000 407 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(1), GLB1(5), HEXA(3), LCT(2), SLC33A1(2), ST3GAL1(1), ST3GAL5(1), ST6GALNAC3(3), ST6GALNAC5(1), ST6GALNAC6(1), ST8SIA1(2), ST8SIA5(1) 10442846 23 21 23 6 1 4 2 10 6 0 0.399 1.000 1.000 408 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 AGA(1), ARSB(1), FUCA2(1), GALNS(2), GBA(2), GLB1(5), GNS(1), GUSB(5), HEXA(3), HGSNAT(1), HPSE(1), HPSE2(3), HYAL1(1), HYAL2(1), IDS(2), IDUA(1), LCT(2), MAN2B2(2), MAN2C1(5), MANBA(1), NAGLU(2), NEU1(1), SPAM1(6) 21861110 50 42 50 10 5 8 6 21 10 0 0.108 1.000 1.000 409 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOA(1), ALDOB(3), G6PD(2), GPI(3), PFKM(3), PFKP(2), PRPS1(1), PRPS1L1(2), PRPS2(3), RPE(1), TALDO1(1), TKT(1) 12977377 23 22 21 8 1 4 4 4 10 0 0.821 1.000 1.000 410 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 B2M(2), CALR(1), CANX(1), CD4(10), CD74(1), CD8A(1), CIITA(3), CTSB(3), CTSS(1), HLA-B(1), HLA-C(2), HLA-DPA1(1), HLA-DPB1(1), HLA-DQB1(2), HLA-DRA(1), HLA-DRB1(1), HLA-E(2), HLA-F(1), HSP90AA1(4), HSP90AB1(3), HSPA5(2), IFI30(1), IFNA1(1), IFNA14(1), IFNA16(1), IFNA21(2), IFNA5(1), IFNA7(1), IFNA8(2), KIR2DL3(1), KIR3DL1(3), KIR3DL3(1), KLRC1(2), KLRC2(3), KLRC3(1), LTA(1), NFYC(2), RFX5(2), RFXAP(1), TAP2(1) 27085430 72 56 65 15 2 8 7 29 25 1 0.608 1.000 1.000 411 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CYB5R3(2), GNE(1), GNPDA1(1), HEXA(3), HK1(5), RENBP(2) 11123051 14 13 14 5 2 0 2 4 6 0 0.743 1.000 1.000 412 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(2), AGT(1), EDNRB(3), EGF(4), EGFR(9), FOS(1), HRAS(1), JUN(2), NFKB1(1), PLCG1(2), PRKCA(2), RELA(5) 13362042 33 29 27 8 4 4 3 10 11 1 0.604 1.000 1.000 413 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6AP1(2), ATP6V0A1(2), ATP6V0A4(1), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(2), ATP6V1B2(2), ATP6V1D(1), ATP6V1G1(1), SHMT1(2) 10593136 18 17 18 6 0 2 4 6 6 0 0.771 1.000 1.000 414 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(5), CD2(2), CD33(1), IFNA1(1), IFNB1(2), IL3(1), IL4(1), ITGAX(3), TLR2(2), TLR4(2), TLR7(3), TLR9(1) 11884722 24 23 23 9 2 4 4 7 7 0 0.810 1.000 1.000 415 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CHUK(1), CREBBP(5), EP300(11), IKBKB(1), IL1B(1), MAP2K3(2), MAP3K7(1), MAPK14(1), NFKB1(1), RELA(5), TGFBR2(1), TLR2(2) 19371642 32 28 26 5 1 3 4 10 13 1 0.288 1.000 1.000 416 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 ARHGDIB(1), CASP10(2), CASP7(1), CASP8(1), CFLAR(1), DAXX(5), DFFB(1), FAF1(1), JUN(2), LMNB1(3), MAP3K1(5), MAP3K7(1), PAK1(2), PAK2(2), PRKDC(10), PTPN13(7), RB1(2), RIPK2(2), SPTAN1(6) 28042411 55 47 55 9 3 6 6 21 19 0 0.0927 1.000 1.000 417 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 CHUK(1), IKBKB(1), IL1R1(1), IRAK1(3), MAP3K1(5), MAP3K7(1), NFKB1(1), RELA(5), RIPK1(1), TLR4(2), TNFRSF1A(1), TRADD(2), TRAF6(2) 15645914 26 23 23 6 1 7 2 4 11 1 0.457 1.000 1.000 418 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(7), ASAH1(1), CERK(5), CREB5(2), EPHB2(2), FOS(1), ITPKB(2), JUN(2), MAP2K7(1), MAPK10(1), MAPK8IP1(3), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2) 17965013 31 28 28 6 5 4 3 11 8 0 0.262 1.000 1.000 419 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 31 ANPEP(5), G6PD(2), GCLC(1), GGT1(2), GSS(1), GSTA3(1), GSTA4(1), GSTM1(1), IDH1(2), IDH2(5) 11898082 21 18 18 8 0 2 5 5 9 0 0.928 1.000 1.000 420 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 ATF2(1), ELK1(1), FOS(1), GRB2(2), HRAS(1), JUN(2), MAP3K1(5), MAPK3(1), MAPK8IP3(1), PAPPA(1), RPS6KA1(7), SHC1(3), SOS1(5), SYK(1), VAV1(3), VAV2(4) 20598662 39 34 35 8 5 6 3 14 10 1 0.290 1.000 1.000 421 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(8), ABCC2(1), BCHE(2), CES1(7), CES2(2), UGT1A1(3), UGT1A4(2), UGT1A5(1), UGT1A6(3), UGT1A7(3) 15191546 32 25 27 7 2 3 4 9 14 0 0.580 1.000 1.000 422 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(1), ACACA(6), ACADM(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH2(2), ECHS1(2), EHHADH(5), HADHA(2), LDHB(1), LDHC(3), MCEE(1), MLYCD(2), MUT(2), PCCA(1), PCCB(3), SUCLA2(1), SUCLG1(5), SUCLG2(2) 21966427 46 42 42 10 3 5 11 12 15 0 0.258 1.000 1.000 423 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(1), GPLD1(1), PGAP1(1), PIGB(1), PIGC(1), PIGG(1), PIGK(1), PIGL(2), PIGM(2), PIGN(2), PIGO(4), PIGP(1), PIGQ(3), PIGT(6), PIGU(1), PIGV(1), PIGZ(3) 15947146 32 30 28 8 1 4 4 12 10 1 0.643 1.000 1.000 424 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 CYP11A1(1), CYP11B2(2), CYP17A1(1), CYP21A2(1), HSD3B1(1) 5903596 6 6 6 3 0 0 1 5 0 0 0.813 1.000 1.000 425 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 CYP11A1(1), CYP11B2(2), CYP17A1(1), CYP21A2(1), HSD3B1(1) 5903596 6 6 6 3 0 0 1 5 0 0 0.813 1.000 1.000 426 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 42 AKT1(1), ASAH1(1), ATF1(2), BRAF(2), CREB5(2), CREBBP(5), EGR1(9), EGR2(1), EGR3(1), ELK1(1), FRS2(2), JUN(2), MAP1B(7), MAP2K7(1), MAPK10(1), MAPK3(1), MAPK8IP1(3), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2), NTRK1(5), PIK3C2G(2), PIK3CA(10), PIK3CD(1), PIK3R1(2), PTPN11(1), SHC1(3), SRC(1), TH(2) 32906311 73 60 61 15 8 15 3 24 22 1 0.190 1.000 1.000 427 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNA1(1), IFNB1(2), IL15(1), IL16(4), IL3(1), IL4(1), LTA(1) 6394068 11 11 11 5 0 4 1 5 1 0 0.786 1.000 1.000 428 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(1), GABRA1(2), GABRA2(1), GABRA3(1), GABRA4(1), GABRA5(1), GPHN(1), SRC(1), UBQLN1(2) 7898767 11 11 11 5 0 3 2 4 2 0 0.838 1.000 1.000 429 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 19 APAF1(2), BID(1), BIK(1), BIRC2(2), BIRC3(2), CASP7(1), CASP8(1), CASP9(1), DFFB(1) 8930987 12 12 12 5 0 2 1 5 4 0 0.815 1.000 1.000 430 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(1), COASY(1), DPYD(4), DPYS(2), ENPP3(1), ILVBL(2), PANK1(2), PANK2(4), PANK3(1), PANK4(1), UPB1(1), VNN1(1) 11219940 21 20 21 8 1 3 3 8 6 0 0.798 1.000 1.000 431 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(2), FOS(1), HRAS(1), JUN(2), MAPK3(1), NFKB1(1), PLCB1(1), PRKCA(2), RAF1(1), RELA(5) 9892034 17 17 14 6 4 3 0 4 5 1 0.755 1.000 1.000 432 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(1), IARS(4), IARS2(2), ILVBL(2), LARS(3), LARS2(2), PDHA1(1), PDHA2(2), PDHB(1), VARS(2), VARS2(2) 11227977 22 18 22 8 0 6 2 8 6 0 0.713 1.000 1.000 433 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(1), ALG10(3), ALG10B(6), ALG11(3), ALG12(2), ALG13(4), ALG14(1), ALG3(2), ALG5(1), ALG6(2), ALG8(1), B4GALT3(2), DOLPP1(2), DPAGT1(5), DPM1(1), MAN1A1(2), MAN1A2(1), MAN2A1(3), MGAT4A(3), MGAT4B(1), MGAT5(3), MGAT5B(2), RPN1(2), RPN2(1), STT3B(3) 27562098 57 47 56 11 0 12 2 21 22 0 0.250 1.000 1.000 434 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(4), ARHGEF1(2), GNA12(1), GNA13(4), GNB1(2), MYL2(1), MYLK(4), PLCB1(1), PPP1R12B(1), PRKCA(2), ROCK1(4) 13493006 26 26 26 8 1 2 0 16 7 0 0.781 1.000 1.000 435 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ADH1A(2), ADH1B(2), ADH4(1), ADH6(1), ADHFE1(2), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH2(2), BAAT(1), CEL(1), CYP27A1(1), HADHB(3), SOAT2(2) 15300366 24 23 21 6 2 2 2 10 8 0 0.741 1.000 1.000 436 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP1(1), ACP2(1), ACP5(2), ACP6(1), ENPP3(1), FLAD1(2), MTMR1(1), MTMR2(1), TYR(5) 9877713 15 15 15 5 0 3 0 9 3 0 0.794 1.000 1.000 437 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CD3E(1), CD3G(2), ETV5(1), IL12RB1(2), IL12RB2(2), IL18R1(1), JAK2(5), JUN(2), MAPK14(1), STAT4(1), TYK2(6) 12283508 24 24 23 7 2 0 3 12 7 0 0.830 1.000 1.000 438 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOA(1), ALDOB(3), G6PD(2), GPI(3), PFKL(1), PFKM(3), PFKP(2), PRPS1(1), PRPS1L1(2), PRPS2(3), RPE(1), TALDO1(1), TKT(1), TKTL1(1), TKTL2(2) 15635698 27 26 25 8 1 5 4 6 11 0 0.709 1.000 1.000 439 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ALDH18A1(2), ARG1(1), ASL(4), CPS1(4), GATM(1), OAT(1), ODC1(2), OTC(1), PYCR1(1), SMS(2) 11356087 19 19 19 6 0 2 4 8 5 0 0.765 1.000 1.000 440 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 FOS(1), GRB2(2), HRAS(1), JAK2(5), JUN(2), MAPK3(1), PIK3CA(10), PIK3R1(2), PLCG1(2), PRKCA(2), RAF1(1), RASA1(3), SHC1(3), SOS1(5), STAT1(3), STAT3(3), STAT5A(2), STAT5B(2) 19635714 50 46 45 11 4 10 4 20 12 0 0.397 1.000 1.000 441 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 37 ANPEP(5), G6PD(2), GCLC(1), GGT1(2), GPX6(1), GSR(1), GSS(1), GSTA3(1), GSTA4(1), GSTA5(1), GSTM1(1), IDH1(2), IDH2(5), OPLAH(2), TXNDC12(1) 14138763 27 23 24 7 0 2 6 8 11 0 0.724 1.000 1.000 442 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 28 BRAF(2), CPEB1(3), EGFR(9), ERBB2(4), ERBB4(6), ETS1(1), ETS2(1), ETV6(2), FMN2(5), GRB2(2), KRAS(1), MAPK3(1), NOTCH1(5), NOTCH2(9), NOTCH3(8), NOTCH4(5), PIWIL1(2), PIWIL2(2), PIWIL3(3), PIWIL4(1), RAF1(1), SOS1(5), SOS2(3), SPIRE1(1), SPIRE2(1) 32271932 83 69 80 17 12 7 10 33 19 2 0.221 1.000 1.000 443 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(7), CALM2(1), CAPN2(2), EP300(11), HDAC1(2), MEF2D(1), NFATC1(2), NFATC2(5), PPP3CA(2), PPP3CC(3), PRKCA(2), SYT1(1) 15555640 39 32 34 10 4 4 4 14 13 0 0.485 1.000 1.000 444 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(2), CD28(1), CSK(3), CTLA4(1), DTYMK(1), EPHB2(2), FBXW7(2), GRAP2(1), GRB2(2), ITK(1), ITPKB(2), LCP2(1), NCK1(1), NFAT5(6), NFKB1(1), NFKB2(1), NFKBIB(1), NFKBIL1(1), PAK1(2), PAK2(2), PAK4(2), PAK6(4), PAK7(2), PLCG1(2), PTPRC(6), RAF1(1), RASGRP1(2), RASGRP2(2), RASGRP3(1), RASGRP4(2), SOS1(5), SOS2(3), VAV1(3) 36156246 69 57 68 12 6 9 7 27 20 0 0.126 1.000 1.000 445 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(5), ACE2(2), AGT(1), AGTR1(2), ANPEP(5), CMA1(1), CTSA(1), ENPEP(2), LNPEP(2), MAS1(1), MME(5), REN(1), THOP1(1) 13831036 29 26 25 8 1 4 8 7 9 0 0.665 1.000 1.000 446 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(2), CALM2(1), ELK1(1), FOS(1), GNAI1(1), GNAS(5), GNB1(2), HRAS(1), JUN(2), MAPK3(1), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), PLCG1(2), PPP3CA(2), PPP3CC(3), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2), PRKCA(2), RAF1(1), SYT1(1) 21997311 51 44 48 12 7 6 2 19 17 0 0.465 1.000 1.000 447 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAS1(5), ALAS2(3), BLVRA(1), COX10(2), COX15(1), CP(1), CPOX(5), EPRS(2), FECH(2), FTMT(3), GUSB(5), HCCS(1), HMOX1(2), MMAB(1), PPOX(1), UGT1A1(3), UGT1A4(2), UGT1A5(1), UGT1A6(3), UGT1A7(3), UGT2A1(3), UGT2A3(2), UGT2B11(2), UGT2B15(1), UGT2B28(3), UGT2B4(2), UGT2B7(3), UROD(1) 27766131 64 56 58 14 5 8 8 24 19 0 0.322 1.000 1.000 448 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 24 GHR(1), GRB2(2), HRAS(1), INSR(4), IRS1(4), JAK2(5), MAPK3(1), PIK3CA(10), PIK3R1(2), PLCG1(2), PRKCA(2), PTPN6(3), RAF1(1), RPS6KA1(7), SHC1(3), SOS1(5), STAT5A(2), STAT5B(2) 21326306 57 50 46 13 5 10 5 18 18 1 0.423 1.000 1.000 449 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 62 AKT1(1), AKT2(3), AKT3(1), BCL10(1), CARD11(8), CD19(1), CD22(4), CD72(1), CHUK(1), CR2(2), FOS(1), GSK3B(3), HRAS(1), IKBKB(1), INPP5D(2), JUN(2), KRAS(1), LILRB3(3), MALT1(1), NFAT5(6), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), NFKB1(1), NFKB2(1), NFKBIB(1), PIK3CA(10), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PLCG2(2), PPP3CA(2), PPP3CC(3), PTPN6(3), RAC3(1), RASGRP3(1), SYK(1), VAV1(3), VAV2(4) 48185133 106 87 95 20 5 19 9 39 34 0 0.104 1.000 1.000 450 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM2(1), CCL2(1), CXCR4(1), FOS(1), JUN(2), MAPK14(1), PLCG1(2), PRKCA(2), PTK2B(3), SYT1(1) 8980806 15 14 14 6 2 4 1 4 4 0 0.819 1.000 1.000 451 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(1), ALDH4A1(1), CAD(9), CPS1(4), EPRS(2), GAD2(1), GCLC(1), GLS(3), GLS2(4), GOT1(3), GOT2(2), GPT(2), GPT2(2), GSS(1), NADSYN1(1), QARS(1) 21914311 38 33 34 7 2 4 7 11 13 1 0.356 1.000 1.000 452 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 AKT1(1), AKT2(3), AKT3(1), CD19(1), CSK(3), EPHB2(2), GRB2(2), ITPKB(2), NFAT5(6), NFKB1(1), NFKB2(1), NFKBIB(1), NFKBIL1(1), PIK3CA(10), PIK3CD(1), PIK3R1(2), PLCG2(2), PPP1R13B(3), RAF1(1), SHC1(3), SOS1(5), SOS2(3), SYK(1), VAV1(3) 33550726 59 52 56 10 5 14 7 21 12 0 0.0318 1.000 1.000 453 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(1), ACOX3(2), FADS2(2), PLA2G10(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(2) 6802671 10 10 10 5 2 1 2 4 1 0 0.775 1.000 1.000 454 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR2(1), ARHGAP1(1), ARHGAP5(4), ARHGAP6(2), ARHGEF1(2), ARHGEF11(5), ARHGEF5(1), ARPC2(8), CFL1(1), DIAPH1(3), GSN(2), LIMK1(4), MYL2(1), MYLK(4), OPHN1(2), PIP5K1A(2), PPP1R12B(1), ROCK1(4), SRC(1), TLN1(6), VCL(2) 29634613 57 49 48 9 2 5 2 18 30 0 0.243 1.000 1.000 455 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 42 CHUK(1), DAXX(5), EGF(4), EGFR(9), ETS1(1), ETS2(1), FOS(1), HRAS(1), IKBKB(1), JUN(2), MAP2K3(2), MAP2K7(1), MAP3K1(5), MAP3K5(5), MAPK13(1), MAPK14(1), MAPK3(1), NFKB1(1), PPP2CA(1), PRKCA(2), PRKCD(3), PRKCE(2), PRKCG(2), PRKCH(4), PRKCQ(4), RAF1(1), RELA(5), RIPK1(1), SP1(2), TNFRSF1A(1), TRAF2(1) 31927150 72 57 66 15 9 7 2 27 26 1 0.387 1.000 1.000 456 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(1), AP2A1(2), ARF1(1), EEA1(6), GSK3A(1), GSK3B(3), PFKL(1), PFKM(3), PFKP(2), PLCG1(2), PRKCE(2), PRKCZ(1), RAB5A(1), RPS6KB1(2), VAV2(4) 16531177 32 28 29 8 2 5 4 9 12 0 0.511 1.000 1.000 457 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 66 APAF1(2), BID(1), BIRC2(2), BIRC3(2), CASP1(2), CASP10(2), CASP2(1), CASP7(1), CASP8(1), CASP9(1), CHUK(1), DFFB(1), FAS(1), HELLS(2), IKBKB(1), IRF5(1), IRF6(5), IRF7(1), JUN(2), LTA(1), MAP3K1(5), MAPK10(1), NFKB1(1), NFKBIB(1), PRF1(1), RELA(5), RIPK1(1), TNFRSF1A(1), TNFRSF21(1), TNFSF10(6), TP53(15), TP73(3), TRADD(2), TRAF2(1), TRAF3(1) 36615953 76 56 64 15 2 11 6 23 31 3 0.256 1.000 1.000 458 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 MRPS7(1), RPL10A(1), RPL11(1), RPL18(2), RPL18A(1), RPL19(1), RPL21(1), RPL22L1(1), RPL27(1), RPL28(1), RPL3(1), RPL30(2), RPL31(1), RPL32(1), RPL34(1), RPL36AL(1), RPL38(1), RPL3L(2), RPL7(1), RPS11(1), RPS13(1), RPS2(1), RPS21(2), RPS24(1), RPS26(1), RPS27(1), RPS29(1), RPS3(2), RPS3A(1), RPS4Y1(1), RPS9(1) 14457472 36 34 36 9 2 3 6 18 7 0 0.494 1.000 1.000 459 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AADAC(1), ABAT(1), ACADS(3), ACSM1(1), AKR1B10(2), ALDH1A3(3), ALDH1B1(1), ALDH2(2), ALDH7A1(1), BDH1(1), BDH2(1), DDHD1(2), ECHS1(2), EHHADH(5), GAD2(1), HADH(1), HADHA(2), HMGCS1(1), HMGCS2(1), ILVBL(2), L2HGDH(1), OXCT1(1), PDHA1(1), PDHA2(2), PDHB(1), PLA1A(3), RDH11(3) 26710355 46 40 42 9 6 7 6 12 15 0 0.192 1.000 1.000 460 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(6), ACACB(4), FASN(3), OLAH(1), OXSM(1) 10057712 15 15 15 5 2 0 4 6 3 0 0.683 1.000 1.000 461 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 ASNS(1), CA14(3), CA5B(1), CA7(1), CA9(1), CPS1(4), CTH(1), GLS(3), GLS2(4), HAL(1) 12473657 20 19 20 6 1 2 2 14 1 0 0.667 1.000 1.000 462 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 20 AKT1(1), APAF1(2), ATM(15), BID(1), CASP7(1), CASP9(1), PRKCA(2), PTK2(1), PXN(1), STAT1(3), TLN1(6), TP53(15) 18131537 49 41 47 11 3 7 3 15 19 2 0.407 1.000 1.000 463 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 64 ATM(15), CCNA1(7), CCND2(1), CCNE1(1), CCNE2(2), CCNG2(1), CCNH(1), CDC25A(1), CDK2(2), CDK4(6), CDKN1A(1), CDKN2A(3), CDKN2C(1), CREB3L1(1), CREB3L4(3), E2F1(1), E2F5(1), GBA2(3), MCM2(6), MCM5(2), MCM6(3), MCM7(5), MNAT1(1), MYT1(2), NACA(10), PCNA(2), POLE(4), POLE2(1), PRIM1(2), RB1(2), RPA1(2), RPA2(1), RPA3(1), TFDP2(5), TNXB(5), TP53(15), WEE1(1) 49024551 121 79 105 22 6 11 10 38 54 2 0.178 1.000 1.000 464 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 ELK1(1), FOS(1), GRB2(2), HRAS(1), JAK2(5), JUN(2), MAPK3(1), PLCG1(2), PTPN6(3), RAF1(1), SHC1(3), SOS1(5), STAT5A(2), STAT5B(2) 13912285 31 29 29 8 3 4 3 12 9 0 0.640 1.000 1.000 465 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 35 DOCK1(1), ELK1(1), FOS(1), GAB1(1), GRB2(2), HGF(1), HRAS(1), ITGA1(5), ITGB1(4), JUN(2), MAP4K1(1), MAPK3(1), MET(6), PAK1(2), PIK3CA(10), PIK3R1(2), PTEN(21), PTK2(1), PTK2B(3), PTPN11(1), PXN(1), RAF1(1), RAP1A(1), RASA1(3), SOS1(5), SRC(1), STAT3(3) 29700800 82 64 77 18 5 18 3 26 29 1 0.327 1.000 1.000 466 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(2), AGT(1), AGTR1(2), CMA1(1), COL4A1(1), COL4A2(1), COL4A3(5), COL4A4(2), COL4A5(7), COL4A6(4), REN(1) 16834151 27 25 27 9 3 10 3 7 4 0 0.534 1.000 1.000 467 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(2), ACSS2(7), ADH1A(2), ADH1B(2), ADH4(1), ADH5(1), ADH6(1), ADHFE1(2), ALDH1A3(3), ALDH1B1(1), ALDH2(2), ALDH3B1(3), ALDH3B2(2), ALDH7A1(1), ALDOA(1), ALDOB(3), DLAT(2), DLD(2), ENO1(3), ENO2(1), ENO3(2), G6PC(3), GALM(2), GAPDH(2), GAPDHS(2), GPI(3), HK1(5), LDHAL6B(1), LDHB(1), LDHC(3), PDHA1(1), PDHA2(2), PDHB(1), PFKL(1), PFKM(3), PFKP(2), PGAM2(1), PGK1(3), TPI1(1) 37949123 81 64 72 17 6 7 11 23 33 1 0.324 1.000 1.000 468 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 GOSR1(1), SNAP23(1), STX10(1), STX11(1), STX16(1), STX19(1), STX2(1), STX4(1), STX7(1), STX8(1), TSNARE1(2), VAMP2(1) 11051827 13 13 13 8 2 2 1 5 3 0 0.926 1.000 1.000 469 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 37 CCNH(1), ERCC3(1), GTF2E1(1), GTF2E2(2), GTF2F2(1), GTF2H1(2), GTF2H2(1), ILK(4), MNAT1(1), POLR1A(4), POLR1B(2), POLR2A(8), POLR2B(4), POLR2F(3), POLR2I(1), POLR3B(3), POLR3H(1), POLR3K(1), TAF5(2), TAF6(1), TAF7(1), TBP(1) 23174090 46 41 42 9 1 6 5 13 21 0 0.324 1.000 1.000 470 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(3), AKR1B10(2), ALDOA(1), ALDOB(3), FPGT(1), FUK(2), GMDS(1), GMPPA(1), GMPPB(1), HK1(5), KHK(3), MPI(1), MTMR1(1), MTMR2(1), PFKFB3(1), PFKL(1), PFKM(3), PFKP(2), PGM2(2), RDH11(3), SORD(10), TPI1(1) 24272749 49 45 42 11 8 3 6 11 21 0 0.493 1.000 1.000 471 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(2), ARHGDIB(1), BIRC2(2), BIRC3(2), CASP1(2), CASP10(2), CASP2(1), CASP7(1), CASP8(1), CASP9(1), DFFB(1), LMNB1(3), PRF1(1) 12493614 20 19 20 7 0 6 2 7 5 0 0.692 1.000 1.000 472 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1A(2), ADH1B(2), ADH4(1), ADH5(1), ADH6(1), ADHFE1(2), AGK(5), AKR1B1(3), ALDH1A3(3), ALDH1B1(1), ALDH2(2), ALDH7A1(1), CEL(1), DAK(2), DGKA(2), DGKB(1), DGKD(1), DGKE(3), DGKG(2), DGKH(3), DGKI(1), DGKQ(1), DGKZ(2), GK(1), GK2(1), GLA(1), GLB1(5), GPAM(2), LCT(2), LIPC(1), LIPF(1), LPL(2), PNLIP(4), PNPLA3(2), PPAP2B(1), PPAP2C(2) 38525819 68 55 65 13 6 10 8 22 22 0 0.120 1.000 1.000 473 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT1(1), AKT2(3), AKT3(1), CD19(1), CD22(4), CR2(2), CSK(3), FLOT2(1), GRB2(2), GSK3A(1), GSK3B(3), INPP5D(2), ITPR1(4), ITPR2(9), ITPR3(4), MAP4K1(1), MAPK3(1), NFATC1(2), NFATC2(5), PDK1(1), PIK3CA(10), PIK3CD(1), PIK3R1(2), PLCG2(2), PPP1R13B(3), PPP3CA(2), PPP3CC(3), PTPRC(6), RAF1(1), SHC1(3), SOS1(5), SOS2(3), SYK(1), VAV1(3) 47914536 96 74 87 18 8 19 10 30 29 0 0.0430 1.000 1.000 474 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(4), DIAPH1(3), FYN(2), GSN(2), HRAS(1), ITGA1(5), ITGB1(4), MAPK3(1), MYL2(1), MYLK(4), PIK3CA(10), PIK3R1(2), PTK2(1), PXN(1), RAF1(1), ROCK1(4), SHC1(3), SRC(1), TLN1(6) 24546785 56 51 52 13 4 11 3 21 17 0 0.346 1.000 1.000 475 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 ELK1(1), FOS(1), GRB2(2), HRAS(1), IGF1R(1), IRS1(4), JUN(2), MAPK3(1), PIK3CA(10), PIK3R1(2), PTPN11(1), RAF1(1), RASA1(3), SHC1(3), SOS1(5) 15775979 38 36 35 10 6 12 2 14 4 0 0.309 1.000 1.000 476 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADCY1(2), ADCY2(4), ADCY3(3), ADCY4(2), ADCY5(5), ADCY6(1), ADCY7(1), ADCY8(8), ADSL(1), AK2(1), AK5(1), ALLC(2), AMPD1(1), AMPD2(1), AMPD3(3), ATIC(2), ATP5A1(2), ATP5B(2), ATP5C1(1), ATP5G2(1), CANT1(1), ENPP3(1), ENTPD2(1), GART(1), GDA(1), GUCY1A2(1), GUCY1A3(2), GUCY1B3(1), GUCY2C(3), GUCY2D(1), GUCY2F(6), HPRT1(1), IMPDH1(1), NPR1(4), NPR2(4), NT5M(2), PAPSS1(2), PAPSS2(2), PDE1A(1), PDE4A(2), PDE4B(1), PDE4C(7), PDE4D(1), PDE5A(1), PDE6B(3), PDE6C(2), PDE8A(2), PDE9A(8), PFAS(2), POLB(1), POLD1(6), POLE(4), POLG(4), POLL(2), POLQ(9), POLR1B(2), POLR2A(8), POLR2B(4), POLR2F(3), POLR2I(1), POLRMT(2), PRPS1(1), PRPS1L1(2), PRPS2(3), PRUNE(2), RRM1(2), RRM2(1) 83661134 166 119 155 28 16 20 15 58 57 0 0.0229 1.000 1.000 477 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSA(1), ARSB(1), ARSE(1), ASAH1(1), GAL3ST1(2), GALC(1), GBA(2), GLA(1), GLB1(5), LCT(2), NEU1(1), PPAP2B(1), PPAP2C(2), SMPD2(2), SPTLC1(1) 15163689 24 22 24 8 1 5 4 8 6 0 0.678 1.000 1.000 478 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(1), ALDH4A1(1), CAD(9), CPS1(4), EPRS(2), GAD2(1), GCLC(1), GFPT2(1), GLS(3), GLS2(4), GOT1(3), GOT2(2), GPT(2), GPT2(2), GSR(1), GSS(1), NADSYN1(1), NAGK(2), QARS(1) 26048357 42 36 38 8 3 4 9 12 13 1 0.301 1.000 1.000 479 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CALM2(1), CAMK1(1), CAMK1G(3), ELK1(1), FPR1(2), GNA15(1), GNB1(2), HRAS(1), MAP2K3(2), MAP3K1(5), MAPK14(1), MAPK3(1), NCF1(1), NCF2(1), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), NFKB1(1), PAK1(2), PIK3C2G(2), PLCB1(1), PPP3CA(2), PPP3CC(3), RAF1(1), RELA(5), SYT1(1) 25044200 56 45 50 13 5 7 3 17 23 1 0.506 1.000 1.000 480 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT1(1), AKT2(3), AKT3(1), ANKRD6(2), APC(7), AXIN1(2), AXIN2(1), CSNK1A1(2), CTNNB1(1), DACT1(1), DVL1(1), FSTL1(2), GSK3A(1), GSK3B(3), LRP1(11), MVP(4), NKD1(2), NKD2(1), PTPRA(3), SENP2(1), WIF1(4) 26105870 54 46 50 12 3 10 7 16 18 0 0.223 1.000 1.000 481 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 ARSB(1), ARSE(1), CYP11B2(2), HSD17B2(1), HSD17B8(1), HSD3B1(1), SULT2A1(1), UGT1A1(3), UGT1A4(2), UGT1A5(1), UGT1A6(3), UGT1A7(3), UGT2B15(1), UGT2B4(2) 17731963 23 21 23 6 1 3 3 7 9 0 0.531 1.000 1.000 482 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 69 ACACB(4), ACSL1(2), ACSL3(13), ACSL4(1), ACSL5(1), ACSL6(4), AKT1(1), AKT2(3), AKT3(1), CAMKK1(2), CAMKK2(2), CHUK(1), CPT1A(1), CPT1C(4), CPT2(1), G6PC(3), IKBKB(1), IRS1(4), IRS4(1), JAK1(4), JAK2(5), JAK3(3), LEP(1), LEPR(1), MAPK10(1), MAPK9(2), NFKB1(1), NFKB2(1), NFKBIB(1), NPY(1), PCK1(4), PCK2(1), POMC(1), PPARGC1A(3), PRKAA2(4), PRKAB1(1), PRKAG1(4), PRKAG2(4), PRKCQ(4), PTPN11(1), RELA(5), RXRB(4), RXRG(2), SLC2A1(1), SOCS3(1), STAT3(3), TNFRSF1A(1), TRADD(2), TRAF2(1), TYK2(6) 52609862 124 93 105 26 5 16 18 42 42 1 0.278 1.000 1.000 483 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 ASNS(1), ASRGL1(4), CA14(3), CA5B(1), CA7(1), CA9(1), CPS1(4), CTH(1), GLS(3), GLS2(4), HAL(1) 13903166 24 23 21 7 1 2 2 14 5 0 0.681 1.000 1.000 484 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(2), BID(1), BIRC2(2), BIRC3(2), CASP10(2), CASP7(1), CASP8(1), CASP9(1), CFLAR(1), CHUK(1), DFFB(1), GAS2(2), NFKB1(1), RELA(5), RIPK1(1), SPTAN1(6), TNFSF10(6), TRADD(2), TRAF2(1) 21839088 39 32 33 8 0 5 4 13 16 1 0.387 1.000 1.000 485 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 49 ACOX1(1), CREBBP(5), EHHADH(5), EP300(11), FABP1(3), JUN(2), LPL(2), MAPK3(1), ME1(1), NCOA1(2), NCOR1(4), NCOR2(6), NR1H3(2), NRIP1(4), PIK3CA(10), PIK3R1(2), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2), PRKCA(2), PTGS2(4), RB1(2), RELA(5), SP1(2), STAT5A(2), STAT5B(2) 40707164 88 64 76 19 4 14 9 30 30 1 0.199 1.000 1.000 486 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(6), ACACB(4), ACSS1(2), ACSS2(7), AKR1B1(3), ALDH1A3(3), ALDH1B1(1), ALDH2(2), ALDH7A1(1), DLAT(2), DLD(2), GLO1(1), GRHPR(2), HAGH(1), LDHAL6B(1), LDHB(1), LDHC(3), MDH1(1), ME1(1), ME2(2), ME3(2), PC(3), PCK1(4), PCK2(1), PDHA1(1), PDHA2(2), PDHB(1) 30516346 60 50 56 13 2 8 11 12 26 1 0.340 1.000 1.000 487 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 98 AKT1(1), AKT2(3), AKT3(1), CASP8(1), CCL3(1), CD86(1), CHUK(1), CXCL11(1), CXCL9(1), FOS(1), IFNA1(1), IFNA14(1), IFNA16(1), IFNA21(2), IFNA5(1), IFNA7(1), IFNA8(2), IFNAR1(2), IFNB1(2), IKBKB(1), IKBKE(1), IL1B(1), IRAK1(3), IRAK4(1), IRF5(1), IRF7(1), JUN(2), LBP(1), LY96(1), MAP2K3(2), MAP2K7(1), MAP3K7(1), MAPK10(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK9(2), NFKB1(1), NFKB2(1), PIK3CA(10), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), RELA(5), RIPK1(1), SPP1(3), STAT1(3), TBK1(2), TICAM1(3), TLR1(1), TLR2(2), TLR4(2), TLR5(2), TLR6(1), TLR7(3), TLR8(5), TLR9(1), TRAF3(1), TRAF6(2) 57605629 112 93 104 20 8 20 12 52 19 1 0.0361 1.000 1.000 488 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ADCY1(2), ADCY8(8), ATF4(2), BRAF(2), CACNA1C(9), CALM2(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(1), CREBBP(5), EP300(11), GRIA1(6), GRIA2(3), GRIN1(2), GRIN2A(6), GRIN2B(6), GRM1(4), GRM5(7), HRAS(1), ITPR1(4), ITPR2(9), ITPR3(4), KRAS(1), MAPK3(1), PLCB1(1), PLCB2(2), PLCB3(2), PLCB4(4), PPP1R12A(2), PPP3CA(2), PPP3CC(3), PRKACA(1), PRKACB(2), PRKACG(2), PRKCA(2), PRKCG(2), RAF1(1), RAP1A(1), RAPGEF3(1), RPS6KA1(7), RPS6KA6(1) 66267243 135 97 125 26 15 14 12 51 41 2 0.0713 1.000 1.000 489 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(2), ALOX5(2), CYP1A2(3), CYP2C18(1), CYP2C19(1), CYP2E1(1), CYP2J2(3), CYP3A7(1), PLA2G10(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(2), RDH11(3) 15699422 22 22 22 8 3 2 3 9 5 0 0.688 1.000 1.000 490 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 91 ACTB(1), CABIN1(7), CALM2(1), CAMK2B(1), CAMK4(1), CD3E(1), CD3G(2), CDKN1A(1), CNR1(1), CREBBP(5), CSNK2B(1), CTLA4(1), EGR2(1), EGR3(1), EP300(11), FOS(1), GATA3(2), GATA4(2), GSK3A(1), GSK3B(3), HRAS(1), ICOS(2), IFNA1(1), IFNB1(2), IL1B(1), IL2RA(2), IL3(1), IL4(1), ITK(1), JUNB(1), MAP2K7(1), MAPK14(1), MAPK9(2), MEF2D(1), NFAT5(6), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), NFKB2(1), NFKBIB(1), NPPB(1), NUP214(3), OPRD1(2), P2RX7(1), PAK1(2), PPP3CC(3), PTPRC(6), RELA(5), SLA(1), SP1(2), SP3(2), TRAF2(1), TRPV6(4), VAV1(3), VAV2(4), XPO5(3) 58343361 129 92 118 26 12 14 16 44 42 1 0.120 1.000 1.000 491 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 CS(2), DLAT(2), DLD(2), IDH2(5), IDH3B(1), IDH3G(2), MDH1(1), OGDH(3), PC(3), PDHA1(1), PDHA2(2), PDHB(1), PDHX(1), PDK1(1), PDK2(2), PDK3(2), PDP2(2), SDHA(1), SDHB(1), SDHD(1), SUCLA2(1), SUCLG1(5), SUCLG2(2) 18653873 44 36 41 12 1 7 6 17 13 0 0.562 1.000 1.000 492 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 ARHGDIB(1), BAG4(1), CASP2(1), CASP8(1), DFFB(1), JUN(2), LMNB1(3), MADD(5), MAP3K1(5), MAP3K7(1), PAK1(2), PAK2(2), PRKDC(10), RB1(2), RIPK1(1), SPTAN1(6), TNFRSF1A(1), TRADD(2), TRAF2(1) 25861196 48 42 48 10 1 7 7 15 18 0 0.221 1.000 1.000 493 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 CALM2(1), ELK1(1), FOS(1), GRB2(2), HRAS(1), JUN(2), MAP2K7(1), MAP3K1(5), MAPK3(1), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), PAK2(2), PIK3CA(10), PIK3R1(2), PLA2G4A(1), PLCG1(2), PPP3CA(2), PPP3CC(3), RAF1(1), SHC1(3), SOS1(5), SYK(1), SYT1(1), VAV1(3) 27670642 66 58 60 16 6 12 5 22 21 0 0.377 1.000 1.000 494 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 CREBBP(5), CTBP1(1), CTBP2(1), DLL1(1), DLL4(2), DTX1(4), DTX3(1), DTX3L(1), DTX4(4), DVL1(1), DVL2(1), EP300(11), HDAC1(2), JAG1(5), JAG2(2), MAML1(5), MAML2(2), MAML3(4), NCOR2(6), NCSTN(1), NOTCH1(5), NOTCH2(9), NOTCH3(8), NOTCH4(5), NUMB(2), NUMBL(1), PSEN2(2), PSENEN(1), PTCRA(1), RBPJ(3), RBPJL(7), SNW1(3) 41783564 107 78 97 25 11 8 14 30 42 2 0.411 1.000 1.000 495 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(6), ADH5(1), AKR1B1(3), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH2(2), DLAT(2), DLD(2), GLO1(1), GRHPR(2), HAGH(1), LDHB(1), LDHC(3), MDH1(1), ME1(1), ME2(2), ME3(2), PC(3), PCK1(4), PDHA1(1), PDHA2(2), PDHB(1) 24117765 47 42 44 11 2 6 7 11 21 0 0.437 1.000 1.000 496 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BAG4(1), BIRC2(2), BIRC3(2), CASP8(1), CFLAR(1), JUN(2), MAP3K3(2), MAP3K7(1), NFKB1(1), NFKB2(1), NFKBIB(1), NFKBIL1(1), NR2C2(1), RALBP1(1), RIPK1(1), TNFRSF1A(1), TRADD(2), TRAF2(1) 17018286 23 22 23 7 0 5 5 9 4 0 0.512 1.000 1.000 497 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 33 AKT1(1), CBL(2), CFLAR(1), E2F1(1), FOS(1), GRB2(2), HRAS(1), IL2RA(2), IL2RB(2), IRS1(4), JAK1(4), JAK3(3), MAPK3(1), PIK3CA(10), PIK3R1(2), PTPN6(3), RAF1(1), RPS6KB1(2), SHC1(3), SOCS3(1), SOS1(5), STAT5A(2), STAT5B(2), SYK(1) 22934644 57 53 53 15 6 13 7 15 16 0 0.324 1.000 1.000 498 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 ARSE(1), CYP11B2(2), CYP19A1(2), HSD17B1(1), HSD17B2(1), HSD17B8(1), HSD3B1(1), LCMT1(1), LCMT2(3), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(3), SULT2A1(1), UGT1A1(3), UGT1A4(2), UGT1A5(1), UGT1A6(3), UGT1A7(3), UGT2A1(3), UGT2A3(2), UGT2B11(2), UGT2B15(1), UGT2B28(3), UGT2B4(2), UGT2B7(3) 32479861 50 45 50 11 4 7 7 19 13 0 0.324 1.000 1.000 499 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPS(1), CHPT1(2), ENPP2(1), PAFAH1B1(1), PAFAH2(1), PLA2G10(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(2), PLD1(2), PLD2(5), PPAP2B(1), PPAP2C(2) 15330061 21 20 19 9 3 2 2 9 5 0 0.901 1.000 1.000 500 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT1(1), AKT2(3), AKT3(1), ASAH1(1), BRAF(2), DRD2(1), EGFR(9), EPHB2(2), GRB2(2), ITPKB(2), ITPR1(4), ITPR2(9), ITPR3(4), KCNJ3(3), PIK3CB(3), PITX2(2), PLCB1(1), PLCB2(2), PLCB3(2), PLCB4(4), RAF1(1), SHC1(3), SOS1(5), SOS2(3), SRC(1), STAT3(3) 38247862 74 56 72 16 8 12 12 26 15 1 0.120 1.000 1.000 501 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(5), ATP6AP1(2), ATP6V0A1(2), ATP6V0A4(1), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(2), ATP6V1B2(2), ATP6V1D(1), ATP6V1G1(1), ATP7A(3), ATP7B(5), COX10(2), NDUFA1(1), NDUFA10(1), NDUFB2(1), NDUFB6(1), NDUFS1(5), NDUFS2(1), NDUFV1(1), NDUFV2(1), PPA2(2), SDHA(1), SDHB(1), SHMT1(2), UQCRC1(1), UQCRFS1(1) 25317507 51 43 50 13 3 9 8 20 11 0 0.357 1.000 1.000 502 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(1), COL4A2(1), COL4A3(5), COL4A4(2), COL4A5(7), COL4A6(4), F11(1), F12(3), F2(2), F5(7), F8(5), F9(2), FGA(2), FGB(1), FGG(5), KLKB1(2), PROC(3), PROS1(4), SERPING1(2) 29418959 59 53 57 16 6 11 3 21 17 1 0.423 1.000 1.000 503 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 AICDA(1), CAD(9), CANT1(1), DCTD(1), DPYD(4), DPYS(2), DTYMK(1), ENTPD5(1), NME7(1), NT5C1B(1), NT5C2(1), NT5M(2), POLA1(1), POLD1(6), POLD3(1), POLE(4), POLE2(1), POLR1A(4), POLR1B(2), POLR1C(2), POLR2A(8), POLR2B(4), POLR2F(3), POLR2I(1), POLR3A(4), POLR3B(3), POLR3G(1), POLR3H(1), POLR3K(1), PRIM1(2), PRIM2(2), RFC5(1), RRM1(2), RRM2(1), TK1(1), TK2(1), TXNRD2(1), UCK1(1), UCK2(1), UMPS(1), UPB1(1), UPP2(2), UPRT(2) 53777536 91 70 83 17 3 16 11 28 32 1 0.0640 1.000 1.000 504 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(2), ADH1B(2), ADH4(1), ADH6(1), ADHFE1(2), AKR1B1(3), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH2(2), CEL(1), DGKA(2), DGKB(1), DGKD(1), DGKE(3), DGKG(2), DGKH(3), DGKQ(1), DGKZ(2), GK(1), GLA(1), GLB1(5), LCT(2), LIPC(1), LIPF(1), LPL(2), PNLIP(4), PPAP2B(1), PPAP2C(2) 31560764 55 44 52 13 6 9 5 16 19 0 0.314 1.000 1.000 505 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 57 ASH1L(4), ASH2L(2), CTCFL(2), DOT1L(2), EHMT1(3), EHMT2(3), EZH1(1), EZH2(4), FBXO11(2), HCFC1(6), HSF4(3), JMJD4(1), JMJD6(4), KDM6A(3), MEN1(1), NSD1(8), OGT(4), PAXIP1(1), PRDM2(1), PRDM6(1), PRDM7(2), PRDM9(3), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(3), RBBP5(3), SATB1(2), SETD1A(4), SETD2(52), SETD7(1), SETDB1(4), SETMAR(2), SMYD3(2), SUV39H2(4), SUV420H1(2), SUZ12(5), WHSC1(4), WHSC1L1(5) 79066801 157 116 153 29 9 19 14 45 67 3 0.0542 1.000 1.000 506 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOA(1), ALDOB(3), DLAT(2), DLD(2), ENO1(3), ENO2(1), ENO3(2), G6PC(3), GAPDH(2), GAPDHS(2), GOT1(3), GOT2(2), GPI(3), HK1(5), LDHAL6B(1), LDHB(1), LDHC(3), MDH1(1), PC(3), PCK1(4), PDHA1(1), PDHA2(2), PDHB(1), PDHX(1), PFKL(1), PFKM(3), PFKP(2), PGAM2(1), PGK1(3), TNFAIP1(1), TPI1(1) 27486661 64 52 60 17 4 6 9 15 30 0 0.584 1.000 1.000 507 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(2), ADH1B(2), ADH4(1), ADH6(1), ADHFE1(2), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH2(2), ALDH3B1(3), ALDH3B2(2), ALDOA(1), ALDOB(3), DLAT(2), DLD(2), ENO1(3), ENO2(1), ENO3(2), G6PC(3), GAPDH(2), GPI(3), HK1(5), LDHB(1), LDHC(3), PDHA1(1), PDHA2(2), PDHB(1), PFKM(3), PFKP(2), PGK1(3), TPI1(1) 31870819 65 52 57 16 6 4 7 20 28 0 0.587 1.000 1.000 508 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(2), ADH1B(2), ADH4(1), ADH6(1), ADHFE1(2), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH2(2), ALDH3B1(3), ALDH3B2(2), ALDOA(1), ALDOB(3), DLAT(2), DLD(2), ENO1(3), ENO2(1), ENO3(2), G6PC(3), GAPDH(2), GPI(3), HK1(5), LDHB(1), LDHC(3), PDHA1(1), PDHA2(2), PDHB(1), PFKM(3), PFKP(2), PGK1(3), TPI1(1) 31870819 65 52 57 16 6 4 7 20 28 0 0.587 1.000 1.000 509 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 BLVRA(1), CP(1), CPOX(5), EPRS(2), FECH(2), GUSB(5), HCCS(1), HMOX1(2), PPOX(1), UGT1A1(3), UGT1A4(2), UGT1A5(1), UGT1A6(3), UGT1A7(3), UGT2B15(1), UGT2B4(2), UROD(1) 18053735 36 33 32 10 4 4 4 10 14 0 0.676 1.000 1.000 510 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 85 ABL1(4), ABL2(4), AKT1(1), AKT2(3), AKT3(1), BRAF(2), CAMK2B(1), CAMK2D(1), CAMK2G(2), CBL(2), CBLB(2), CBLC(1), CDKN1A(1), EGF(4), EGFR(9), ELK1(1), ERBB2(4), ERBB3(4), ERBB4(6), GAB1(1), GRB2(2), GSK3B(3), HRAS(1), JUN(2), KRAS(1), MAP2K7(1), MAPK10(1), MAPK3(1), MAPK9(2), NCK1(1), NRG1(1), NRG2(2), NRG3(2), PAK1(2), PAK2(2), PAK4(2), PAK6(4), PAK7(2), PIK3CA(10), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PLCG1(2), PLCG2(2), PRKCA(2), PRKCG(2), PTK2(1), RAF1(1), RPS6KB1(2), RPS6KB2(2), SHC1(3), SHC2(1), SOS1(5), SOS2(3), SRC(1), STAT5A(2), STAT5B(2) 66806047 141 102 130 29 11 25 17 49 38 1 0.0934 1.000 1.000 511 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 51 ALG6(2), CCKBR(1), CELSR1(11), CELSR2(6), CELSR3(5), CHRM2(3), CHRM3(2), CIDEB(1), EMR2(2), EMR3(9), FSHR(2), GPR116(4), GPR133(3), GPR143(1), GPR17(2), GPR61(1), GPR84(3), GRM1(4), GRPR(1), HRH4(1), LGR6(2), LPHN2(3), LPHN3(8), NTSR1(1), P2RY11(1), P2RY13(1), PTGFR(3), SMO(3), TSHR(2) 41481571 88 67 84 21 13 14 7 27 27 0 0.187 1.000 1.000 512 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(1), COL4A2(1), COL4A3(5), COL4A4(2), COL4A5(7), COL4A6(4), SLC23A1(4), SLC23A2(1), SLC2A1(1), SLC2A3(2) 16805555 28 27 28 10 3 10 1 9 5 0 0.704 1.000 1.000 513 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 AKT1(1), APC(7), ASAH1(1), DLG4(1), EPHB2(2), GNAI1(1), ITPR1(4), ITPR2(9), ITPR3(4), KCNJ3(3), PITX2(2), RHO(1), RYR1(13) 29642229 49 44 49 12 9 8 7 17 8 0 0.172 1.000 1.000 514 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 55 BMP2(1), BMP4(1), BMP5(1), BMP6(1), BMP7(3), BMP8A(4), BMP8B(1), BTRC(2), CSNK1A1(2), CSNK1G2(1), CSNK1G3(1), FBXW11(1), GLI1(4), GLI2(4), GLI3(5), GSK3B(3), HHIP(3), LRP2(17), PRKACA(1), PRKACB(2), PRKACG(2), PTCH1(9), PTCH2(2), SHH(1), SMO(3), STK36(2), SUFU(1), WNT10A(1), WNT11(1), WNT2(1), WNT3(1), WNT3A(1), WNT5B(1), WNT7B(1), WNT8A(2), WNT9B(1) 37361099 88 72 78 22 10 9 6 37 26 0 0.508 1.000 1.000 515 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 88 ACVR1(1), ACVR1B(3), ACVR1C(3), ACVR2A(1), ACVR2B(1), AMHR2(7), BMP2(1), BMP4(1), BMP5(1), BMP6(1), BMP7(3), BMP8A(4), BMP8B(1), BMPR1B(1), BMPR2(5), CHRD(3), CREBBP(5), CUL1(3), DCN(3), E2F5(1), EP300(11), GDF5(1), GDF6(1), INHBA(2), INHBB(1), INHBC(1), INHBE(1), LEFTY2(1), LTBP1(3), MAPK3(1), NODAL(1), PITX2(2), PPP2CA(1), PPP2CB(1), PPP2R1A(1), PPP2R1B(1), PPP2R2A(3), PPP2R2B(3), PPP2R2C(1), RBL2(2), ROCK1(4), ROCK2(2), RPS6KB1(2), RPS6KB2(2), SMAD2(2), SMAD3(1), SMAD4(1), SMAD5(1), SMAD9(1), SMURF1(1), SMURF2(2), SP1(2), TGFB2(1), TGFBR2(1), THBS1(11), THBS2(1), THBS3(4), THBS4(1), ZFYVE16(1), ZFYVE9(5) 63765341 134 101 121 27 9 9 15 49 52 0 0.230 1.000 1.000 516 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 AGMAT(1), ALDH18A1(2), ALDH1A3(3), ALDH1B1(1), ALDH2(2), ALDH7A1(1), AOC2(3), AOC3(1), ARG1(1), ASL(4), ASS1(2), CPS1(4), GATM(1), MAOA(1), ODC1(2), OTC(1), SAT1(1), SMS(2) 19122684 33 33 31 10 0 5 6 10 12 0 0.725 1.000 1.000 517 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 99 ADCY1(2), ADCY2(4), ADCY3(3), ADCY4(2), ADCY5(5), ADCY6(1), ADCY7(1), ADCY8(8), ADCY9(4), CALM2(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CREB3L1(1), CREB3L2(1), CREB3L4(3), CREBBP(5), CTNNB1(1), DCT(4), DVL1(1), DVL2(1), EDNRB(3), EP300(11), FZD1(1), FZD10(3), FZD2(2), FZD3(1), FZD4(3), FZD5(1), GNAI1(1), GNAI2(1), GNAO1(1), GNAS(5), GSK3B(3), HRAS(1), KITLG(2), KRAS(1), LEF1(1), MAPK3(1), MC1R(2), MITF(2), PLCB1(1), PLCB2(2), PLCB3(2), PLCB4(4), POMC(1), PRKACA(1), PRKACB(2), PRKACG(2), PRKCA(2), PRKCG(2), RAF1(1), TCF7L2(1), TYR(5), TYRP1(1), WNT10A(1), WNT11(1), WNT2(1), WNT3(1), WNT3A(1), WNT5B(1), WNT7B(1), WNT8A(2), WNT9B(1) 68695131 135 100 129 28 14 13 16 59 33 0 0.0728 1.000 1.000 518 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AADAT(1), ALDH1A3(3), ALDH1B1(1), ALDH2(2), ALDH7A1(1), AOC2(3), AOC3(1), AOX1(7), CAT(2), CYP1A1(1), CYP1A2(3), CYP1B1(1), DDC(2), ECHS1(2), EHHADH(5), GCDH(3), HAAO(1), HADH(1), HADHA(2), LCMT1(1), LCMT2(3), MAOA(1), NFX1(1), OGDH(3), OGDHL(2), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(3), TPH1(1), TPH2(1), WARS(1), WARS2(1) 39559123 65 56 60 15 4 12 10 20 19 0 0.327 1.000 1.000 519 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(2), CARS(6), DARS(1), EPRS(2), HARS(1), IARS(4), LARS(3), LARS2(2), MARS(2), MARS2(3), QARS(1), RARS(2), SARS(2), TARS(5), WARS(1), WARS2(1), YARS(1) 21368148 39 32 36 10 0 4 6 17 12 0 0.598 1.000 1.000 520 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(1), AKT2(3), AKT3(1), ARHGEF11(5), CDC42(1), DLG4(1), GNA13(4), LPA(6), MAP3K1(5), MAP3K5(5), NFKB1(1), NFKB2(1), NFKBIB(1), NFKBIL1(1), PDK1(1), PHKA2(3), PIK3CB(3), PLD1(2), PLD2(5), PLD3(3), PTK2(1), RDX(1), ROCK1(4), ROCK2(2), TBXA2R(2) 31808522 63 54 59 15 4 7 7 26 19 0 0.447 1.000 1.000 521 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 47 FN3K(1), IMPA2(3), INPP4A(2), INPP4B(2), INPP5A(1), INPP5B(2), INPP5E(1), INPPL1(2), IPMK(1), ITPK1(1), ITPKB(2), MINPP1(1), MIOX(2), OCRL(2), PI4KA(9), PI4KB(3), PIK3C3(2), PIK3CA(10), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIP4K2A(2), PIP4K2B(2), PIP4K2C(3), PIP5K1A(2), PIP5K1C(1), PLCB1(1), PLCB2(2), PLCB3(2), PLCB4(4), PLCD1(1), PLCD3(1), PLCD4(3), PLCE1(3), PLCG1(2), PLCG2(2), PLCZ1(2), PTEN(21), PTPMT1(1), SYNJ1(5), SYNJ2(5) 48426727 119 92 112 29 8 17 8 38 46 2 0.467 1.000 1.000 522 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 39 ARNTL(3), BTG1(2), CLOCK(1), EIF4G2(3), ETV6(2), HERPUD1(1), HSPA8(7), IDI1(1), KLF9(2), MYF6(2), NCKAP1(1), NCOA4(5), NR1D2(1), PER1(4), PER2(4), PPP1R3C(1), PPP2CB(1), PSMA4(2), SF3A3(1), TOB1(2), UGP2(1), ZFR(4) 23817899 51 48 50 14 2 7 10 17 15 0 0.490 1.000 1.000 523 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(11), B3GALT4(1), CDR1(2), DGKI(1), IL6ST(3), PIGK(1), RPL11(1), RPL18(2), RPL18A(1), RPL19(1), RPL21(1), RPL22(2), RPL23(1), RPL27(1), RPL28(1), RPL3(1), RPL30(2), RPL31(1), RPL32(1), RPL34(1), RPL38(1), RPL3L(2), RPL4(2), RPL5(3), RPL7(1), RPLP0(1), RPS11(1), RPS13(1), RPS14(1), RPS19(1), RPS2(1), RPS21(2), RPS24(1), RPS26(1), RPS27(1), RPS27A(1), RPS29(1), RPS3(2), RPS3A(1), RPS4Y1(1), RPS6KA1(7), RPS6KA6(1), RPS6KB1(2), RPS6KB2(2), RPS9(1), TBC1D10C(1), TSPAN9(1), UBB(1), UBC(3) 33964219 81 71 77 19 4 7 13 31 25 1 0.491 1.000 1.000 524 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(3), AKR1B10(2), G6PC(3), GAA(1), GALK1(1), GALK2(1), GALT(3), GANC(2), GLA(1), GLB1(5), HK1(5), LALBA(1), LCT(2), MGAM(5), PFKL(1), PFKM(3), PFKP(2), RDH11(3), UGP2(1) 24901001 45 40 44 13 4 6 6 13 16 0 0.597 1.000 1.000 525 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 AGXT(1), ALAS1(5), ALAS2(3), AOC2(3), AOC3(1), BHMT(2), CHDH(2), CHKB(2), CTH(1), DAO(1), DLD(2), DMGDH(4), GATM(1), GLDC(3), MAOA(1), PISD(1), PLCB2(2), PLCG1(2), PLCG2(2), SARDH(3), SARS(2), SHMT1(2), SHMT2(3), TARS(5) 27427385 54 50 50 15 5 7 9 14 19 0 0.499 1.000 1.000 526 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(1), ARG1(1), ASL(4), ASS1(2), CPS1(4), DAO(1), EPRS(2), GATM(1), GOT1(3), GOT2(2), LAP3(2), NOS1(9), NOS3(2), OAT(1), OTC(1), P4HA1(3), P4HA2(1), PARS2(3), PRODH(1), PYCR1(1), PYCR2(1), RARS(2) 23285057 48 43 48 14 3 5 11 17 12 0 0.609 1.000 1.000 527 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 70 ADH1A(2), ADH1B(2), ADH4(1), ADH5(1), ADH6(1), ADHFE1(2), AKR1C1(1), ALDH1A3(3), ALDH3B1(3), ALDH3B2(2), CYP1A1(1), CYP1A2(3), CYP1B1(1), CYP2B6(1), CYP2C18(1), CYP2C19(1), CYP2E1(1), CYP2F1(1), CYP3A7(1), DHDH(2), EPHX1(4), GSTA3(1), GSTA4(1), GSTA5(1), GSTM1(1), UGT1A1(3), UGT1A4(2), UGT1A5(1), UGT1A6(3), UGT1A7(3), UGT2A1(3), UGT2A3(2), UGT2B11(2), UGT2B15(1), UGT2B28(3), UGT2B4(2), UGT2B7(3) 38058446 67 53 63 17 7 7 9 24 20 0 0.481 1.000 1.000 528 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACADM(1), ACOX1(1), ACOX2(1), ACOX3(2), ACSL1(2), ACSL3(13), ACSL4(1), ACSL5(1), ACSL6(4), ANGPTL4(2), APOA5(2), AQP7(3), CPT1A(1), CPT1C(4), CPT2(1), CYP27A1(1), CYP4A11(4), CYP8B1(3), DBI(1), EHHADH(5), FABP1(3), FABP3(1), FADS2(2), GK(1), GK2(1), HMGCS2(1), ILK(4), LPL(2), ME1(1), NR1H3(2), PCK1(4), PCK2(1), PLTP(2), PPARD(1), PPARG(2), RXRB(4), RXRG(2), SCP2(2), SLC27A1(2), SLC27A2(1), SLC27A5(2), SLC27A6(6), SORBS1(1), UBC(3), UCP1(1) 42196205 105 79 88 28 6 11 14 41 33 0 0.583 1.000 1.000 529 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(1), CDC7(1), CDK2(2), CDT1(1), DIAPH2(2), MCM10(2), MCM2(6), MCM5(2), MCM6(3), MCM7(5), NACA(10), PCNA(2), POLD1(6), POLD3(1), POLE(4), POLE2(1), PRIM1(2), RFC1(4), RFC2(1), RFC4(1), RFC5(1), RPA1(2), RPA2(1), RPA3(1), RPA4(1), RPS27A(1), UBB(1), UBC(3) 33302474 68 55 60 18 5 7 6 24 26 0 0.689 1.000 1.000 530 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 B3GALT1(1), B3GALT2(2), B3GALT4(1), B3GALT5(1), B3GNT1(1), B3GNT2(3), B3GNT3(1), B3GNT5(1), B4GALT3(2), B4GALT4(2), B4GALT6(1), FUT6(2), GBGT1(2), GCNT2(2), PIGB(1), PIGC(1), PIGG(1), PIGK(1), PIGL(2), PIGM(2), PIGN(2), PIGO(4), PIGP(1), PIGQ(3), PIGT(6), PIGU(1), PIGV(1), PIGZ(3), ST3GAL1(1), ST3GAL3(3), ST3GAL4(1), ST3GAL5(1), ST6GALNAC3(3), ST6GALNAC5(1), ST6GALNAC6(1), ST8SIA1(2), ST8SIA5(1) 30918368 65 54 60 19 5 9 8 18 24 1 0.702 1.000 1.000 531 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTN1(1), ACTN2(3), BCAR1(3), CAPN1(1), CSK(3), FYN(2), GRB2(2), HRAS(1), ITGA1(5), ITGB1(4), JUN(2), MAPK3(1), PPP1R12B(1), PTK2(1), PXN(1), RAF1(1), RAP1A(1), ROCK1(4), SHC1(3), SOS1(5), SRC(1), TLN1(6), VCL(2), ZYX(1) 30457734 55 46 54 15 4 8 2 26 15 0 0.633 1.000 1.000 532 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSA(1), ARSE(1), ASAH1(1), B4GALT6(1), CERK(5), DEGS1(2), ENPP7(2), GAL3ST1(2), GALC(1), GBA(2), GLA(1), GLB1(5), LCT(2), NEU1(1), PPAP2B(1), PPAP2C(2), SGPP1(2), SMPD2(2), SPHK2(1), SPTLC1(1), UGT8(1) 22215704 37 33 34 12 4 7 5 10 11 0 0.685 1.000 1.000 533 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 192 ACTB(1), ACTG1(3), ACTN1(1), ACTN2(3), ACTN4(2), AKT1(1), AKT2(3), AKT3(1), ARHGAP5(4), BCAR1(3), BIRC2(2), BIRC3(2), BRAF(2), CAPN2(2), CAV2(1), CCND2(1), CDC42(1), CHAD(2), COL11A1(8), COL11A2(4), COL1A1(2), COL1A2(8), COL2A1(5), COL3A1(2), COL4A1(1), COL4A2(1), COL4A4(2), COL4A6(4), COL5A1(4), COL5A2(5), COL5A3(10), COL6A1(1), COL6A2(6), COL6A3(12), COL6A6(13), CTNNB1(1), DIAPH1(3), DOCK1(1), EGF(4), EGFR(9), ELK1(1), ERBB2(4), FARP2(2), FIGF(1), FLNA(4), FLNB(4), FLNC(5), FLT1(7), FN1(4), FYN(2), GRB2(2), GSK3B(3), HGF(1), HRAS(1), IBSP(1), IGF1R(1), ILK(4), ITGA1(5), ITGA10(3), ITGA11(5), ITGA2(2), ITGA3(3), ITGA4(2), ITGA5(3), ITGA6(4), ITGA7(4), ITGA9(1), ITGAV(1), ITGB1(4), ITGB3(1), ITGB4(2), ITGB5(1), ITGB6(2), ITGB7(3), ITGB8(1), JUN(2), KDR(5), LAMA1(9), LAMA2(7), LAMA3(7), LAMA4(6), LAMA5(5), LAMB1(8), LAMB2(3), LAMB3(1), LAMB4(3), LAMC1(5), LAMC2(6), LAMC3(5), MAPK10(1), MAPK3(1), MAPK9(2), MET(6), MYL2(1), MYL7(1), MYL9(1), MYLK(4), MYLK2(1), PAK1(2), PAK2(2), PAK4(2), PAK6(4), PAK7(2), PARVB(1), PARVG(1), PDGFC(1), PDGFD(2), PDGFRA(5), PDGFRB(1), PGF(2), PIK3CA(10), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PIP5K1C(1), PPP1R12A(2), PRKCA(2), PRKCG(2), PTEN(21), PTK2(1), PXN(1), RAC3(1), RAF1(1), RAP1A(1), RAPGEF1(3), RELN(5), ROCK1(4), ROCK2(2), SHC1(3), SHC2(1), SOS1(5), SOS2(3), SPP1(3), SRC(1), THBS1(11), THBS2(1), THBS3(4), THBS4(1), TLN1(6), TLN2(8), TNC(8), TNN(2), TNR(8), TNXB(5), VAV1(3), VAV2(4), VCL(2), VEGFC(2), VTN(1), VWF(11), ZYX(1) 239556698 515 256 493 140 50 74 52 172 164 3 0.299 1.000 1.000 534 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 168 ADCY1(2), ADCY2(4), ADCY3(3), ADCY4(2), ADCY7(1), ADCY8(8), ADCY9(4), ADORA2A(1), ADORA2B(1), ADRA1A(4), ADRB2(2), AGTR1(2), ATP2A1(6), ATP2A2(6), ATP2A3(4), ATP2B1(1), ATP2B3(1), ATP2B4(3), AVPR1A(1), BDKRB1(1), BDKRB2(1), CACNA1A(5), CACNA1B(4), CACNA1C(9), CACNA1D(6), CACNA1E(3), CACNA1F(4), CACNA1G(7), CACNA1H(3), CACNA1I(3), CACNA1S(8), CALM2(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(1), CCKAR(2), CCKBR(1), CD38(1), CHRM2(3), CHRM3(2), CHRM5(2), CHRNA7(1), CYSLTR1(1), DRD1(1), EDNRB(3), EGFR(9), ERBB2(4), ERBB3(4), ERBB4(6), GNA15(1), GNAS(5), GRIN1(2), GRIN2A(6), GRM1(4), GRM5(7), GRPR(1), HRH2(1), HTR2A(1), HTR2C(1), HTR4(1), HTR6(1), HTR7(2), ITPKB(2), ITPR1(4), ITPR2(9), ITPR3(4), MYLK(4), MYLK2(1), NOS1(9), NOS3(2), NTSR1(1), P2RX1(2), P2RX2(3), P2RX3(2), P2RX7(1), PDE1A(1), PDE1B(5), PDE1C(1), PDGFRA(5), PDGFRB(1), PHKA1(5), PHKA2(3), PHKB(2), PHKG1(2), PHKG2(1), PLCB1(1), PLCB2(2), PLCB3(2), PLCB4(4), PLCD1(1), PLCD3(1), PLCD4(3), PLCE1(3), PLCG1(2), PLCG2(2), PLCZ1(2), PPID(1), PPP3CA(2), PPP3CC(3), PRKACA(1), PRKACB(2), PRKACG(2), PRKCA(2), PRKCG(2), PTAFR(1), PTGER3(5), PTGFR(3), PTK2B(3), RYR1(13), RYR2(11), RYR3(13), SLC25A4(2), SLC25A6(1), SLC8A1(1), SLC8A2(2), SLC8A3(3), SPHK2(1), TACR1(1), TACR3(2), TBXA2R(2), TRHR(2), TRPC1(2), VDAC3(1) 176508822 366 224 349 95 53 47 29 136 101 0 0.113 1.000 1.000 535 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 246 ACVR1B(3), ACVR1C(3), AKT1(1), AKT2(3), AKT3(1), ARRB2(1), ATF2(1), ATF4(2), BRAF(2), CACNA1A(5), CACNA1B(4), CACNA1C(9), CACNA1D(6), CACNA1E(3), CACNA1F(4), CACNA1G(7), CACNA1H(3), CACNA1I(3), CACNA1S(8), CACNA2D1(3), CACNA2D4(3), CACNB1(1), CACNB2(1), CACNB4(1), CACNG3(2), CACNG5(1), CACNG6(1), CACNG7(1), CDC25B(1), CDC42(1), CHUK(1), DAXX(5), DUSP10(1), DUSP3(2), DUSP4(1), DUSP5(1), DUSP8(1), DUSP9(1), ECSIT(4), EGF(4), EGFR(9), ELK1(1), ELK4(2), FAS(1), FGF10(1), FGF11(1), FGF13(1), FGF14(1), FGF19(1), FGF20(1), FGF3(1), FGF6(2), FGF7(2), FGFR1(5), FGFR2(4), FGFR3(1), FGFR4(3), FLNA(4), FLNB(4), FLNC(5), FOS(1), GNA12(1), GRB2(2), HRAS(1), IKBKB(1), IL1B(1), IL1R1(1), IL1R2(4), JUN(2), KRAS(1), MAP2K3(2), MAP2K5(1), MAP2K7(1), MAP3K1(5), MAP3K10(3), MAP3K12(4), MAP3K13(2), MAP3K2(2), MAP3K3(2), MAP3K4(5), MAP3K5(5), MAP3K6(2), MAP3K7(1), MAP4K1(1), MAP4K3(4), MAP4K4(2), MAPK10(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK7(1), MAPK8IP1(3), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2), MAPKAPK2(1), MAPT(3), MAX(5), MKNK1(2), MKNK2(1), MOS(1), MRAS(1), NF1(9), NFATC2(5), NFATC4(3), NFKB1(1), NFKB2(1), NTRK1(5), NTRK2(1), PAK1(2), PAK2(2), PDGFRA(5), PDGFRB(1), PLA2G10(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(2), PPM1B(2), PPP3CA(2), PPP3CC(3), PPP5C(2), PRKACA(1), PRKACB(2), PRKACG(2), PRKCA(2), PRKCG(2), PTPN5(3), PTPN7(1), PTPRR(3), RAC3(1), RAF1(1), RAP1A(1), RAPGEF2(7), RASA1(3), RASA2(1), RASGRF1(3), RASGRF2(3), RASGRP1(2), RASGRP2(2), RASGRP3(1), RASGRP4(2), RPS6KA1(7), RPS6KA4(1), RPS6KA5(1), RPS6KA6(1), RRAS2(8), SOS1(5), SOS2(3), TAOK2(2), TAOK3(1), TGFB2(1), TGFBR2(1), TNFRSF1A(1), TP53(15), TRAF2(1), TRAF6(2), ZAK(3) 187165167 385 221 364 83 38 55 32 138 118 4 0.0228 1.000 1.000 536 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 202 ABI2(2), ACTN1(1), ACTN2(3), ACTN4(2), APC(7), ARHGEF1(2), ARHGEF12(2), ARHGEF6(2), ARHGEF7(4), ARPC2(8), ARPC5L(1), BCAR1(3), BDKRB1(1), BDKRB2(1), BRAF(2), CDC42(1), CFL1(1), CHRM2(3), CHRM3(2), CHRM5(2), CSK(3), CYFIP1(5), CYFIP2(5), DIAPH1(3), DIAPH2(2), DIAPH3(4), DOCK1(1), EGF(4), EGFR(9), EZR(1), F2(2), FGD1(2), FGF10(1), FGF11(1), FGF13(1), FGF14(1), FGF19(1), FGF20(1), FGF3(1), FGF6(2), FGF7(2), FGFR1(5), FGFR2(4), FGFR3(1), FGFR4(3), FN1(4), GIT1(1), GNA12(1), GNA13(4), GSN(2), HRAS(1), IQGAP1(3), IQGAP2(3), IQGAP3(4), ITGA1(5), ITGA10(3), ITGA11(5), ITGA2(2), ITGA3(3), ITGA4(2), ITGA5(3), ITGA6(4), ITGA7(4), ITGA9(1), ITGAD(9), ITGAE(5), ITGAL(5), ITGAM(5), ITGAV(1), ITGAX(3), ITGB1(4), ITGB2(1), ITGB3(1), ITGB4(2), ITGB5(1), ITGB6(2), ITGB7(3), ITGB8(1), KRAS(1), LIMK1(4), LIMK2(2), MAPK3(1), MOS(1), MRAS(1), MSN(2), MYH10(2), MYH14(4), MYL2(1), MYL7(1), MYL9(1), MYLK(4), MYLK2(1), NCKAP1(1), NCKAP1L(3), PAK1(2), PAK2(2), PAK4(2), PAK6(4), PAK7(2), PDGFRA(5), PDGFRB(1), PFN4(1), PIK3CA(10), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PIP4K2A(2), PIP4K2B(2), PIP4K2C(3), PIP5K1A(2), PIP5K1C(1), PPP1R12A(2), PPP1R12B(1), PTK2(1), PXN(1), RAC3(1), RAF1(1), RDX(1), ROCK1(4), ROCK2(2), RRAS2(8), SCIN(1), SLC9A1(2), SOS1(5), SOS2(3), SSH1(2), SSH2(8), SSH3(2), TIAM1(6), TIAM2(1), VAV1(3), VAV2(4), VCL(2), WASF2(2), WASL(6) 181384471 365 209 334 87 24 43 42 131 124 1 0.203 1.000 1.000 537 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 ACTB(1), ACTG1(3), CHAD(2), COL11A1(8), COL11A2(4), COL17A1(3), COL1A1(2), COL1A2(8), COL2A1(5), COL3A1(2), COL4A1(1), COL4A2(1), COL4A4(2), COL4A6(4), COL5A1(4), COL5A2(5), COL5A3(10), COL6A1(1), COL6A2(6), COL6A3(12), COL6A6(13), DSC2(2), DSG1(3), DSG2(2), DSG3(2), DSG4(2), FN1(4), GJA10(2), GJA3(1), GJA5(5), GJA8(1), GJA9(1), GJB1(1), GJB3(1), GJB6(2), GJC1(1), GJC2(1), GJD2(1), IBSP(1), ITGA6(4), ITGB4(2), KRT1(1), KRT10(1), KRT12(2), KRT13(3), KRT15(1), KRT16(1), KRT17(2), KRT19(1), KRT2(2), KRT23(2), KRT24(1), KRT25(1), KRT27(2), KRT28(2), KRT3(1), KRT31(1), KRT33B(2), KRT36(2), KRT39(1), KRT4(4), KRT5(2), KRT6A(1), KRT6B(2), KRT6C(1), KRT7(1), KRT71(2), KRT72(2), KRT73(2), KRT74(2), KRT75(3), KRT76(1), KRT77(1), KRT78(3), KRT79(4), KRT82(2), KRT83(1), KRT84(2), KRT85(4), KRT86(1), LAMA1(9), LAMA2(7), LAMA3(7), LAMA4(6), LAMA5(5), LAMB1(8), LAMB2(3), LAMB3(1), LAMB4(3), LAMC1(5), LAMC2(6), LAMC3(5), LMNB1(3), NES(6), PRPH(1), RELN(5), SPP1(3), THBS1(11), THBS2(1), THBS3(4), THBS4(1), TNC(8), TNN(2), TNR(8), TNXB(5), VIM(1), VTN(1), VWF(11) 157743068 342 203 331 108 38 50 33 104 116 1 0.734 1.000 1.000 538 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 234 ADCYAP1R1(2), ADORA2A(1), ADORA2B(1), ADRA1A(4), ADRA2B(1), ADRB2(2), AGTR1(2), AVPR1A(1), AVPR2(2), BDKRB1(1), BDKRB2(1), BRS3(1), C3AR1(1), C5AR1(2), CALCR(2), CALCRL(1), CCKAR(2), CCKBR(1), CGA(1), CHRM2(3), CHRM3(2), CHRM5(2), CNR1(1), CNR2(2), CRHR1(1), CRHR2(2), CYSLTR1(1), DRD1(1), DRD2(1), DRD3(2), DRD5(1), EDNRB(3), F2(2), F2RL1(1), F2RL2(1), FPR1(2), FSHR(2), GABBR1(3), GABRA1(2), GABRA2(1), GABRA3(1), GABRA4(1), GABRA5(1), GABRB1(2), GABRB3(1), GABRE(3), GABRG1(2), GABRG2(3), GABRQ(7), GABRR1(2), GALR1(1), GH2(1), GHR(1), GIPR(1), GLP1R(1), GLP2R(2), GLRA1(2), GLRA2(1), GLRB(1), GPR156(1), GPR35(2), GPR50(1), GPR63(1), GPR83(1), GRIA1(6), GRIA2(3), GRIA3(2), GRIA4(3), GRID1(3), GRID2(6), GRIK1(2), GRIK2(4), GRIK3(4), GRIK5(4), GRIN1(2), GRIN2A(6), GRIN2B(6), GRIN3B(2), GRM1(4), GRM2(2), GRM3(3), GRM4(3), GRM5(7), GRM6(2), GRM7(4), GRM8(2), GRPR(1), HRH2(1), HRH4(1), HTR1A(2), HTR1D(2), HTR1E(3), HTR1F(1), HTR2A(1), HTR2C(1), HTR4(1), HTR6(1), HTR7(2), LEP(1), LEPR(1), MAS1(1), MC1R(2), MC2R(2), MC3R(2), MC4R(1), MC5R(1), MCHR2(2), MTNR1B(1), NMUR2(4), NPBWR1(1), NPBWR2(1), NPFFR2(2), NTSR1(1), OPRD1(2), OPRL1(1), OPRM1(3), P2RX1(2), P2RX2(3), P2RX3(2), P2RX7(1), P2RY1(1), P2RY10(1), P2RY11(1), P2RY13(1), P2RY14(1), P2RY2(1), P2RY4(1), P2RY8(2), PARD3(5), PRLR(2), PRSS3(2), PTAFR(1), PTGER2(1), PTGER3(5), PTGER4(1), PTGFR(3), PTGIR(1), RXFP1(1), RXFP2(1), SCTR(1), SSTR1(1), SSTR3(1), SSTR4(1), TAAR2(1), TACR1(1), TACR3(2), TBXA2R(2), THRA(1), TRHR(2), TRPV1(1), TSHR(2), VIPR1(1) 140192782 288 185 275 84 39 37 27 108 77 0 0.430 1.000 1.000 539 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(5), CD44(2), CHAD(2), COL11A1(8), COL11A2(4), COL1A1(2), COL1A2(8), COL2A1(5), COL3A1(2), COL4A1(1), COL4A2(1), COL4A4(2), COL4A6(4), COL5A1(4), COL5A2(5), COL5A3(10), COL6A1(1), COL6A2(6), COL6A3(12), COL6A6(13), FN1(4), FNDC1(1), FNDC3A(2), FNDC5(1), HMMR(1), HSPG2(9), IBSP(1), ITGA1(5), ITGA10(3), ITGA11(5), ITGA2(2), ITGA3(3), ITGA4(2), ITGA5(3), ITGA6(4), ITGA7(4), ITGA9(1), ITGAV(1), ITGB1(4), ITGB3(1), ITGB4(2), ITGB5(1), ITGB6(2), ITGB7(3), ITGB8(1), LAMA1(9), LAMA2(7), LAMA3(7), LAMA4(6), LAMA5(5), LAMB1(8), LAMB2(3), LAMB3(1), LAMB4(3), LAMC1(5), LAMC2(6), LAMC3(5), RELN(5), SDC3(1), SPP1(3), SV2A(1), SV2B(1), SV2C(1), THBS1(11), THBS2(1), THBS3(4), THBS4(1), TNC(8), TNN(2), TNR(8), TNXB(5), VTN(1), VWF(11) 142965294 292 185 282 90 30 43 30 87 101 1 0.704 1.000 1.000 540 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 130 ACTB(1), ACTG1(3), ACTN1(1), ACTN2(3), ACTN4(2), AKT1(1), AKT2(3), AKT3(1), AMOTL1(1), ASH1L(4), CASK(1), CDC42(1), CDK4(6), CGN(1), CLDN10(2), CLDN15(1), CLDN16(1), CLDN18(1), CLDN2(1), CLDN4(2), CLDN6(1), CLDN7(1), CSNK2A2(1), CSNK2B(1), CTNNA1(4), CTNNA2(4), CTNNA3(2), CTNNB1(1), EPB41(2), EPB41L1(1), EPB41L2(1), EPB41L3(4), EXOC4(2), F11R(1), GNAI1(1), GNAI2(1), HCLS1(1), HRAS(1), IGSF5(4), INADL(4), JAM3(1), KRAS(1), LLGL1(5), LLGL2(1), MAGI1(3), MAGI2(4), MAGI3(4), MLLT4(8), MPDZ(4), MPP5(1), MRAS(1), MYH1(4), MYH10(2), MYH11(8), MYH13(3), MYH14(4), MYH15(3), MYH2(9), MYH3(5), MYH4(10), MYH6(4), MYH7(8), MYH7B(4), MYH8(5), MYL2(1), MYL7(1), MYL9(1), OCLN(2), PARD3(5), PARD6B(4), PPM1J(3), PPP2CA(1), PPP2CB(1), PPP2R1A(1), PPP2R1B(1), PPP2R2A(3), PPP2R2B(3), PPP2R2C(1), PPP2R3A(1), PPP2R3B(1), PPP2R4(1), PRKCA(2), PRKCD(3), PRKCE(2), PRKCG(2), PRKCH(4), PRKCI(2), PRKCQ(4), PRKCZ(1), PTEN(21), RRAS2(8), SPTAN1(6), SRC(1), TJAP1(1), TJP1(2), TJP2(2), TJP3(1), YES1(1), ZAK(3) 127258964 274 167 253 73 25 31 17 84 115 2 0.561 1.000 1.000 541 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(2), ADCY2(4), ADCY3(3), ADCY4(2), ADCY5(5), ADCY6(1), ADCY7(1), ADCY8(8), ADCY9(4), ADRA1A(4), ADRB2(2), ANXA6(2), ARRB2(1), ATP1A4(4), ATP2A2(6), ATP2A3(4), ATP2B1(1), ATP2B3(1), CACNA1A(5), CACNA1B(4), CACNA1C(9), CACNA1D(6), CACNA1E(3), CACNA1S(8), CACNB1(1), CALM2(1), CALR(1), CAMK1(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(1), CASQ1(4), CASQ2(2), CHRM2(3), CHRM3(2), CHRM5(2), GJA5(5), GJB1(1), GJB3(1), GJB6(2), GNAI2(1), GNAO1(1), GNAZ(1), GNB1(2), GNB3(2), GNB5(2), GNG3(1), GRK4(1), GRK5(1), GRK6(5), ITPR1(4), ITPR2(9), ITPR3(4), KCNB1(1), KCNJ3(3), MYCBP(1), NME7(1), PKIA(1), PLCB3(2), PRKACA(1), PRKACB(2), PRKAR1A(2), PRKAR2B(2), PRKCA(2), PRKCD(3), PRKCE(2), PRKCG(2), PRKCH(4), PRKCQ(4), PRKCZ(1), PRKD1(3), RGS11(1), RGS17(2), RGS18(2), RGS2(2), RGS3(3), RGS6(2), RGS9(4), RYR1(13), RYR2(11), RYR3(13), SLC8A1(1), SLC8A3(3), USP5(2), YWHAB(1) 124492271 252 165 243 69 41 32 19 87 73 0 0.219 1.000 1.000 542 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 127 ABL1(4), ABLIM1(4), ABLIM2(1), ABLIM3(3), ARHGEF12(2), CDC42(1), CFL1(1), CXCR4(1), DCC(4), DPYSL2(2), EFNA3(1), EFNB1(1), EFNB3(12), EPHA1(3), EPHA3(2), EPHA4(1), EPHA5(5), EPHA6(2), EPHA7(1), EPHA8(3), EPHB1(1), EPHB2(2), EPHB4(4), EPHB6(5), FES(3), FYN(2), GNAI1(1), GNAI2(1), GSK3B(3), HRAS(1), ITGB1(4), KRAS(1), L1CAM(5), LIMK1(4), LIMK2(2), MAPK3(1), MET(6), NCK1(1), NFAT5(6), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), NGEF(1), NRP1(2), NTN4(2), NTNG1(1), PAK1(2), PAK2(2), PAK4(2), PAK6(4), PAK7(2), PLXNA1(2), PLXNA2(2), PLXNA3(3), PLXNB1(4), PLXNB2(3), PLXNC1(3), PPP3CA(2), PPP3CC(3), PTK2(1), RAC3(1), RASA1(3), RGS3(3), RND1(2), ROBO1(2), ROBO2(5), ROBO3(1), ROCK1(4), ROCK2(2), SEMA3A(2), SEMA3C(1), SEMA3D(2), SEMA3E(2), SEMA3F(1), SEMA3G(1), SEMA4A(1), SEMA4B(1), SEMA4C(1), SEMA4D(1), SEMA4F(6), SEMA4G(2), SEMA5A(5), SEMA5B(1), SEMA6C(4), SEMA6D(3), SLIT1(2), SLIT2(7), SLIT3(5), SRGAP1(4), SRGAP2(1), SRGAP3(3), UNC5A(2), UNC5B(3), UNC5C(2), UNC5D(2) 125480090 251 156 222 62 18 28 21 83 100 1 0.531 1.000 1.000 543 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 137 ADCY1(2), ADCY2(4), ADCY3(3), ADCY4(2), ADCY5(5), ADCY6(1), ADCY7(1), ADCY8(8), ADCY9(4), ARRB2(1), ATF1(2), ATF2(1), ATF4(2), ATF5(1), ATP2A2(6), ATP2A3(4), CALCA(1), CALM2(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CNN2(3), CORIN(2), CRHR1(1), DGKZ(2), ETS2(1), FOS(1), GABPA(1), GABPB2(1), GBA2(3), GNB1(2), GNB3(2), GNB5(2), GNG3(1), GRK4(1), GRK5(1), GRK6(5), GSTO1(1), GUCA2A(1), GUCY1A3(2), IGFBP2(2), IGFBP3(1), IGFBP4(1), IGFBP6(1), IL1B(1), ITPR1(4), ITPR2(9), ITPR3(4), JUN(2), MYL2(1), MYLK2(1), NFKB1(1), NOS1(9), NOS3(2), PDE4B(1), PDE4D(1), PKIA(1), PLCB3(2), PLCD1(1), PLCG1(2), PLCG2(2), PRKACA(1), PRKACB(2), PRKAR1A(2), PRKAR2B(2), PRKCA(2), PRKCD(3), PRKCE(2), PRKCH(4), PRKCQ(4), PRKCZ(1), PRKD1(3), RAMP1(1), RAMP2(1), RAMP3(1), RGS11(1), RGS17(2), RGS18(2), RGS2(2), RGS3(3), RGS6(2), RGS9(4), RLN1(1), RYR1(13), RYR2(11), RYR3(13), SLC8A1(1), SP1(2), TNXB(5), USP5(2), YWHAB(1) 112147180 229 155 222 55 34 32 19 79 65 0 0.160 1.000 1.000 544 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 250 ACVR1(1), ACVR1B(3), ACVR2A(1), ACVR2B(1), AMHR2(7), BMP2(1), BMP7(3), BMPR1B(1), BMPR2(5), CCL2(1), CCL27(1), CCL3(1), CCR6(1), CCR9(1), CD27(1), CLCF1(1), CSF1R(4), CSF2RA(2), CSF2RB(1), CSF3R(2), CX3CR1(1), CXCL11(1), CXCL9(1), CXCR4(1), CXCR6(1), EDA(1), EGF(4), EGFR(9), FAS(1), FLT1(7), FLT3(6), FLT4(7), GDF5(1), GH2(1), GHR(1), HGF(1), IFNA1(1), IFNA14(1), IFNA16(1), IFNA21(2), IFNA5(1), IFNA7(1), IFNA8(2), IFNAR1(2), IFNB1(2), IFNGR1(2), IFNGR2(2), IFNK(1), IL11RA(1), IL12RB1(2), IL12RB2(2), IL13RA1(1), IL15(1), IL15RA(1), IL17RA(1), IL17RB(1), IL18R1(1), IL18RAP(3), IL19(2), IL1B(1), IL1R1(1), IL1R2(4), IL1RAP(4), IL20RA(1), IL21(1), IL21R(3), IL22RA1(1), IL22RA2(1), IL23A(1), IL23R(4), IL25(2), IL26(1), IL2RA(2), IL2RB(2), IL3(1), IL4(1), IL4R(2), IL6R(2), IL6ST(3), IL9R(2), INHBA(2), INHBB(1), INHBC(1), INHBE(1), KDR(5), KITLG(2), LEP(1), LEPR(1), LIFR(2), LTA(1), LTB(1), LTBR(2), MET(6), NGFR(1), OSMR(1), PDGFC(1), PDGFRA(5), PDGFRB(1), PF4(1), PLEKHO2(1), PRLR(2), RELT(1), TGFB2(1), TGFBR2(1), TNFRSF10C(1), TNFRSF11B(1), TNFRSF13B(1), TNFRSF1A(1), TNFRSF21(1), TNFRSF4(1), TNFRSF9(1), TNFSF10(6), TNFSF14(1), TNFSF15(1), TNFSF9(1), TPO(4), VEGFC(2), XCL1(1), XCR1(1) 115120482 223 153 209 41 16 30 21 88 68 0 0.0189 1.000 1.000 545 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 129 ACACA(6), ACACB(4), AKT1(1), AKT2(3), AKT3(1), BRAF(2), CALM2(1), CBL(2), CBLB(2), CBLC(1), ELK1(1), EXOC7(4), FASN(3), FLOT2(1), FOXO1(1), G6PC(3), GRB2(2), GSK3B(3), GYS1(3), GYS2(1), HRAS(1), IKBKB(1), INPP5D(2), INSR(4), IRS1(4), IRS4(1), KRAS(1), LIPE(4), MAPK10(1), MAPK3(1), MAPK9(2), MKNK1(2), MKNK2(1), PCK1(4), PCK2(1), PDE3A(3), PDE3B(1), PFKL(1), PFKM(3), PFKP(2), PHKA1(5), PHKA2(3), PHKB(2), PHKG1(2), PHKG2(1), PIK3CA(10), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PPARGC1A(3), PPP1R3A(3), PPP1R3C(1), PPP1R3D(1), PRKAA2(4), PRKAB1(1), PRKACA(1), PRKACB(2), PRKACG(2), PRKAG1(4), PRKAG2(4), PRKAR1A(2), PRKAR2B(2), PRKCI(2), PRKCZ(1), PTPN1(1), PTPRF(4), PYGB(2), PYGL(1), PYGM(3), RAF1(1), RAPGEF1(3), RHEB(3), RHOQ(1), RPS6KB1(2), RPS6KB2(2), SH2B2(1), SHC1(3), SHC2(1), SOCS3(1), SOCS4(1), SORBS1(1), SOS1(5), SOS2(3), SREBF1(2), TRIP10(1), TSC1(1), TSC2(5) 102633158 203 146 188 35 18 31 21 75 56 2 0.00462 1.000 1.000 546 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 150 AKT1(1), AKT2(3), AKT3(1), CBL(2), CBLB(2), CBLC(1), CCND2(1), CLCF1(1), CREBBP(5), CSF2RA(2), CSF2RB(1), CSF3R(2), EP300(11), GH2(1), GHR(1), GRB2(2), IFNA1(1), IFNA14(1), IFNA16(1), IFNA21(2), IFNA5(1), IFNA7(1), IFNA8(2), IFNAR1(2), IFNB1(2), IFNGR1(2), IFNGR2(2), IFNK(1), IL11RA(1), IL12RB1(2), IL12RB2(2), IL13RA1(1), IL15(1), IL15RA(1), IL19(2), IL20RA(1), IL21(1), IL21R(3), IL22RA1(1), IL22RA2(1), IL23A(1), IL23R(4), IL26(1), IL2RA(2), IL2RB(2), IL3(1), IL4(1), IL4R(2), IL6R(2), IL6ST(3), IL9R(2), IRF9(2), JAK1(4), JAK2(5), JAK3(3), LEP(1), LEPR(1), LIFR(2), OSMR(1), PIAS1(4), PIAS2(1), PIAS3(2), PIK3CA(10), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PRLR(2), PTPN11(1), PTPN6(3), SOCS3(1), SOCS4(1), SOCS5(1), SOS1(5), SOS2(3), SPRED1(6), SPRED2(1), SPRY1(1), SPRY2(2), SPRY4(10), STAM(2), STAT1(3), STAT2(6), STAT3(3), STAT4(1), STAT5A(2), STAT5B(2), STAT6(4), TPO(4), TYK2(6) 94558184 213 140 196 47 13 31 31 72 66 0 0.113 1.000 1.000 547 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 143 APC(7), AXIN1(2), AXIN2(1), BTRC(2), CACYBP(3), CAMK2B(1), CAMK2D(1), CAMK2G(2), CCND2(1), CHD8(3), CREBBP(5), CSNK1A1(2), CSNK2A2(1), CSNK2B(1), CTBP1(1), CTBP2(1), CTNNB1(1), CUL1(3), CXXC4(2), DAAM1(2), DVL1(1), DVL2(1), EP300(11), FBXW11(1), FZD1(1), FZD10(3), FZD2(2), FZD3(1), FZD4(3), FZD5(1), GSK3B(3), JUN(2), LEF1(1), LRP5(3), LRP6(4), MAP3K7(1), MAPK10(1), MAPK9(2), NFAT5(6), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), NKD1(2), NKD2(1), PLCB1(1), PLCB2(2), PLCB3(2), PLCB4(4), PORCN(1), PPARD(1), PPP2CA(1), PPP2CB(1), PPP2R1A(1), PPP2R1B(1), PPP2R2A(3), PPP2R2B(3), PPP2R2C(1), PPP3CA(2), PPP3CC(3), PRICKLE1(3), PRICKLE2(1), PRKACA(1), PRKACB(2), PRKACG(2), PRKCA(2), PRKCG(2), RAC3(1), ROCK1(4), ROCK2(2), SENP2(1), SFRP2(1), SFRP4(2), SFRP5(1), SMAD2(2), SMAD3(1), SMAD4(1), TBL1X(2), TBL1XR1(3), TCF7L2(1), TP53(15), VANGL1(1), VANGL2(3), WIF1(4), WNT10A(1), WNT11(1), WNT2(1), WNT3(1), WNT3A(1), WNT5B(1), WNT7B(1), WNT8A(2), WNT9B(1) 102183611 203 136 191 51 12 22 25 75 67 2 0.358 1.000 1.000 548 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 129 ALCAM(2), CADM1(2), CADM3(1), CD2(2), CD22(4), CD28(1), CD34(2), CD4(10), CD6(2), CD86(1), CD8A(1), CDH1(1), CDH2(6), CDH3(3), CDH4(4), CDH5(3), CLDN10(2), CLDN15(1), CLDN16(1), CLDN18(1), CLDN2(1), CLDN4(2), CLDN6(1), CLDN7(1), CNTN1(4), CNTN2(2), CNTNAP1(7), CNTNAP2(5), CTLA4(1), ESAM(1), F11R(1), GLG1(4), HLA-B(1), HLA-C(2), HLA-DPA1(1), HLA-DPB1(1), HLA-DQB1(2), HLA-DRA(1), HLA-DRB1(1), HLA-E(2), HLA-F(1), ICAM1(1), ICOS(2), ICOSLG(1), ITGA4(2), ITGA6(4), ITGA9(1), ITGAL(5), ITGAM(5), ITGAV(1), ITGB1(4), ITGB2(1), ITGB7(3), ITGB8(1), JAM3(1), L1CAM(5), MPZL1(1), NCAM2(1), NEGR1(2), NEO1(2), NFASC(5), NRCAM(2), NRXN1(7), NRXN2(3), NRXN3(3), OCLN(2), PTPRC(6), PTPRF(4), PTPRM(3), PVRL2(3), PVRL3(2), SDC3(1), SELE(4), SELP(2), SELPLG(2), SIGLEC1(2), SPN(1), VCAM1(3), VCAN(6) 93306626 196 133 185 61 15 26 22 75 57 1 0.801 1.000 1.000 549 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADCY1(2), ADCY2(4), ADCY3(3), ADCY4(2), ADCY5(5), ADCY6(1), ADCY7(1), ADCY8(8), ADCY9(4), ADSL(1), ADSSL1(1), AK2(1), AK5(1), AK7(1), ALLC(2), AMPD1(1), AMPD2(1), AMPD3(3), ATIC(2), CANT1(1), ENPP3(1), ENTPD2(1), ENTPD5(1), GART(1), GDA(1), GMPR(1), GUCY1A2(1), GUCY1A3(2), GUCY1B3(1), GUCY2C(3), GUCY2D(1), GUCY2F(6), HPRT1(1), IMPDH1(1), NME7(1), NPR1(4), NPR2(4), NT5C1B(1), NT5C2(1), NT5M(2), NUDT5(3), NUDT9(1), PAPSS1(2), PAPSS2(2), PDE10A(1), PDE11A(5), PDE1A(1), PDE1C(1), PDE2A(1), PDE3B(1), PDE4A(2), PDE4B(1), PDE4C(7), PDE4D(1), PDE5A(1), PDE8A(2), PDE8B(1), PDE9A(8), PFAS(2), POLA1(1), POLD1(6), POLD3(1), POLE(4), POLE2(1), POLR1A(4), POLR1B(2), POLR1C(2), POLR2A(8), POLR2B(4), POLR2F(3), POLR2I(1), POLR3A(4), POLR3B(3), POLR3G(1), POLR3H(1), POLR3K(1), PRIM1(2), PRIM2(2), PRPS1(1), PRPS1L1(2), PRPS2(3), PRUNE(2), RFC5(1), RRM1(2), RRM2(1), XDH(5) 107731605 191 127 178 33 14 27 18 66 66 0 0.0210 1.000 1.000 550 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 75 ACP1(1), ACTB(1), ACTG1(3), ACTN1(1), ACTN2(3), ACTN4(2), ACVR1B(3), ACVR1C(3), CDC42(1), CDH1(1), CREBBP(5), CSNK2A2(1), CSNK2B(1), CTNNA1(4), CTNNA2(4), CTNNA3(2), CTNNB1(1), CTNND1(5), EGFR(9), EP300(11), ERBB2(4), FARP2(2), FER(2), FGFR1(5), FYN(2), IGF1R(1), INSR(4), IQGAP1(3), LEF1(1), LMO7(10), MAP3K7(1), MAPK3(1), MET(6), MLLT4(8), PARD3(5), PTPN1(1), PTPN6(3), PTPRB(3), PTPRF(4), PTPRJ(7), PTPRM(3), PVRL2(3), PVRL3(2), RAC3(1), SMAD2(2), SMAD3(1), SMAD4(1), SNAI1(1), SNAI2(2), SORBS1(1), SRC(1), SSX2IP(1), TCF7L2(1), TGFBR2(1), TJP1(2), VCL(2), WASF2(2), WASF3(2), WASL(6), YES1(1) 78785612 171 125 153 42 17 14 23 62 55 0 0.364 1.000 1.000 551 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY1(2), ADCY2(4), ADCY3(3), ADCY4(2), ADCY5(5), ADCY6(1), ADCY7(1), ADCY8(8), ADCY9(4), ATF4(2), CACNA1C(9), CACNA1D(6), CACNA1F(4), CACNA1S(8), CALM2(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CDC42(1), CGA(1), EGFR(9), ELK1(1), GNAS(5), GRB2(2), HRAS(1), ITPR1(4), ITPR2(9), ITPR3(4), JUN(2), KRAS(1), MAP2K3(2), MAP2K7(1), MAP3K1(5), MAP3K2(2), MAP3K3(2), MAP3K4(5), MAPK10(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK7(1), MAPK9(2), MMP14(1), MMP2(6), PLA2G10(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(2), PLCB1(1), PLCB2(2), PLCB3(2), PLCB4(4), PLD1(2), PLD2(5), PRKACA(1), PRKACB(2), PRKACG(2), PRKCA(2), PRKCD(3), PTK2B(3), RAF1(1), SOS1(5), SOS2(3), SRC(1) 84485985 180 125 176 45 23 27 19 71 40 0 0.139 1.000 1.000 552 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 109 ABL1(4), ANAPC1(4), ANAPC2(1), ANAPC4(5), ANAPC5(1), ANAPC7(2), ATM(15), ATR(7), BUB1B(1), BUB3(1), CCNA1(7), CCNB2(5), CCNB3(4), CCND2(1), CCNE1(1), CCNE2(2), CCNH(1), CDC14A(5), CDC16(3), CDC20(1), CDC23(2), CDC25A(1), CDC25B(1), CDC25C(2), CDC27(1), CDC6(1), CDC7(1), CDK2(2), CDK4(6), CDKN1A(1), CDKN2A(3), CDKN2C(1), CHEK2(1), CREBBP(5), CUL1(3), E2F1(1), EP300(11), ESPL1(7), FZR1(3), GSK3B(3), HDAC1(2), MAD2L1(1), MCM2(6), MCM5(2), MCM6(3), MCM7(5), PCNA(2), PRKDC(10), RB1(2), RBL2(2), SKP2(1), SMAD2(2), SMAD3(1), SMAD4(1), SMC1A(2), SMC1B(2), TGFB2(1), TP53(15), WEE1(1), YWHAB(1) 90202137 189 123 173 39 9 22 21 59 75 3 0.0795 1.000 1.000 553 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(1), AKT3(1), BCAR1(3), CAPN1(1), CAPN10(1), CAPN11(1), CAPN2(2), CAPN3(6), CAPN6(2), CAPN7(1), CAPN9(2), CAV2(1), CDC42(1), CSK(3), DOCK1(1), FYN(2), GIT2(2), GRB2(2), ILK(4), ITGA10(3), ITGA11(5), ITGA2(2), ITGA3(3), ITGA4(2), ITGA5(3), ITGA6(4), ITGA7(4), ITGA9(1), ITGAD(9), ITGAE(5), ITGAL(5), ITGAM(5), ITGAV(1), ITGAX(3), ITGB1(4), ITGB2(1), ITGB3(1), ITGB4(2), ITGB5(1), ITGB6(2), ITGB7(3), ITGB8(1), MAP2K3(2), MAPK10(1), MAPK12(1), MAPK4(1), MAPK7(1), MYLK2(1), PAK1(2), PAK2(2), PAK4(2), PAK6(4), PIK3R2(2), PTK2(1), PXN(1), RAC3(1), RAPGEF1(3), RHO(1), ROCK1(4), ROCK2(2), SDCCAG8(1), SEPP1(1), SHC1(3), SORBS1(1), SOS1(5), SRC(1), TLN1(6), TNS1(7), VAV2(4), VCL(2), ZYX(1) 88189962 171 123 162 48 9 26 19 58 59 0 0.590 1.000 1.000 554 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 92 ADCY1(2), ADCY2(4), ADCY3(3), ADCY4(2), ADCY5(5), ADCY6(1), ADCY7(1), ADCY8(8), ADCY9(4), DRD1(1), DRD2(1), EGF(4), EGFR(9), GJD2(1), GNAI1(1), GNAI2(1), GNAS(5), GRB2(2), GRM1(4), GRM5(7), GUCY1A2(1), GUCY1A3(2), GUCY1B3(1), GUCY2C(3), GUCY2D(1), GUCY2F(6), HRAS(1), HTR2A(1), HTR2C(1), ITPR1(4), ITPR2(9), ITPR3(4), KRAS(1), MAP2K5(1), MAP3K2(2), MAPK3(1), MAPK7(1), NPR1(4), NPR2(4), PDGFC(1), PDGFD(2), PDGFRA(5), PDGFRB(1), PLCB1(1), PLCB2(2), PLCB3(2), PLCB4(4), PRKACA(1), PRKACB(2), PRKACG(2), PRKCA(2), PRKCG(2), PRKG1(3), PRKG2(2), RAF1(1), SOS1(5), SOS2(3), SRC(1), TJP1(2), TUBA1A(2), TUBA3C(1), TUBA3D(1), TUBA4A(4), TUBAL3(3), TUBB(2), TUBB1(2), TUBB2B(2) 85841526 175 121 171 39 19 25 17 68 46 0 0.152 1.000 1.000 555 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 78 ABL1(4), ACTN1(1), ACTR2(1), AKT1(1), AKT2(3), AKT3(1), ARHGEF6(2), ARHGEF7(4), BCAR1(3), BRAF(2), CDC42(1), CDKN2A(3), CSE1L(2), DOCK1(1), EPHB2(2), FYN(2), GRB2(2), GRB7(2), ILK(4), ITGA1(5), ITGA10(3), ITGA11(5), ITGA2(2), ITGA3(3), ITGA4(2), ITGA5(3), ITGA6(4), ITGA7(4), ITGA9(1), MAP2K7(1), MAP3K11(1), MAPK10(1), MAPK8IP1(3), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2), MRAS(1), MYLK(4), MYLK2(1), PAK1(2), PAK2(2), PAK4(2), PAK6(4), PAK7(2), PIK3CA(10), PIK3CB(3), PLCG1(2), PLCG2(2), PTEN(21), PTK2(1), RAF1(1), RALA(2), RHO(1), ROCK1(4), ROCK2(2), SHC1(3), SOS1(5), SOS2(3), SRC(1), TLN1(6), TLN2(8), ZYX(1) 79963137 177 120 168 39 8 31 17 57 62 2 0.127 1.000 1.000 556 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTN2(3), ACTN4(2), DMD(7), MYBPC1(2), MYBPC2(3), MYH3(5), MYH6(4), MYH7(8), MYH8(5), MYL1(3), MYL2(1), MYL9(1), MYOM1(5), NEB(12), TMOD1(5), TNNI1(2), TNNT1(2), TNNT2(1), TNNT3(1), TPM2(1), TPM3(1), TTN(83), VIM(1) 93467529 158 120 154 44 14 28 14 63 36 3 0.421 1.000 1.000 557 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY1(2), ADCY2(4), ADCY3(3), ADCY4(2), ADCY5(5), ADCY6(1), ADCY7(1), ADCY8(8), ADCY9(4), AKAP1(2), AKAP10(1), AKAP11(2), AKAP12(5), AKAP2(2), AKAP3(1), AKAP4(2), AKAP6(4), AKAP7(1), AKAP8(2), AKAP9(18), ARHGEF1(2), CALM2(1), CHMP1B(2), GNA12(1), GNA13(4), GNA15(1), GNAI2(1), GNAO1(1), GNAZ(1), GNB1(2), GNB3(2), GNB5(2), GNG3(1), HRAS(1), IL18BP(1), ITPR1(4), KCNJ3(3), KRAS(1), PDE1A(1), PDE1B(5), PDE1C(1), PDE4A(2), PDE4B(1), PDE4C(7), PDE4D(1), PDE8A(2), PDE8B(1), PLCB3(2), PPP3CA(2), PPP3CC(3), PRKACA(1), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2), PRKCA(2), PRKCD(3), PRKCE(2), PRKCG(2), PRKCH(4), PRKCI(2), PRKCQ(4), PRKCZ(1), PRKD1(3), PRKD3(3), SLC9A1(2), USP5(2) 76969295 168 119 162 38 18 22 5 68 54 1 0.204 1.000 1.000 558 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 109 ACTN1(1), ACTN2(3), ACTN4(2), ARHGAP5(4), BCAR1(3), CDC42(1), CDH5(3), CLDN10(2), CLDN15(1), CLDN16(1), CLDN18(1), CLDN2(1), CLDN4(2), CLDN6(1), CLDN7(1), CTNNA1(4), CTNNA2(4), CTNNA3(2), CTNNB1(1), CTNND1(5), CXCR4(1), ESAM(1), EZR(1), F11R(1), GNAI1(1), GNAI2(1), ICAM1(1), ITGA4(2), ITGAL(5), ITGAM(5), ITGB1(4), ITGB2(1), ITK(1), JAM3(1), MAPK12(1), MAPK13(1), MAPK14(1), MLLT4(8), MMP2(6), MMP9(1), MSN(2), MYL2(1), MYL7(1), MYL9(1), NCF1(1), NCF2(1), NOX1(6), NOX3(4), OCLN(2), PIK3CA(10), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PLCG1(2), PLCG2(2), PRKCA(2), PRKCG(2), PTK2(1), PTK2B(3), PTPN11(1), PXN(1), RAP1A(1), RAPGEF3(1), RAPGEF4(1), ROCK1(4), ROCK2(2), SIPA1(1), VAV1(3), VAV2(4), VCAM1(3), VCL(2) 81195193 166 119 155 49 16 24 19 57 50 0 0.596 1.000 1.000 559 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 73 CALM2(1), CDS2(1), DGKA(2), DGKB(1), DGKD(1), DGKE(3), DGKG(2), DGKH(3), DGKI(1), DGKQ(1), DGKZ(2), FN3K(1), IMPA2(3), INPP4A(2), INPP4B(2), INPP5A(1), INPP5B(2), INPP5D(2), INPP5E(1), INPPL1(2), ITPK1(1), ITPKB(2), ITPR1(4), ITPR2(9), ITPR3(4), OCRL(2), PI4KA(9), PI4KB(3), PIK3C2A(3), PIK3C2B(2), PIK3C2G(2), PIK3C3(2), PIK3CA(10), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PIP4K2A(2), PIP4K2B(2), PIP4K2C(3), PIP5K1A(2), PIP5K1C(1), PLCB1(1), PLCB2(2), PLCB3(2), PLCB4(4), PLCD1(1), PLCD3(1), PLCD4(3), PLCE1(3), PLCG1(2), PLCG2(2), PLCZ1(2), PRKCA(2), PRKCG(2), PTEN(21), PTPMT1(1), SYNJ1(5), SYNJ2(5) 82461019 170 117 162 44 14 28 12 56 58 2 0.362 1.000 1.000 560 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 BRAF(2), CACNA1A(5), CRHR1(1), GNA12(1), GNA13(4), GNAI1(1), GNAI2(1), GNAO1(1), GNAS(5), GNAZ(1), GRIA1(6), GRIA2(3), GRIA3(2), GRID2(6), GRM1(4), GRM5(7), GUCY1A2(1), GUCY1A3(2), GUCY1B3(1), GUCY2C(3), GUCY2D(1), GUCY2F(6), HRAS(1), IGF1R(1), ITPR1(4), ITPR2(9), ITPR3(4), KRAS(1), MAPK3(1), NOS1(9), NOS3(2), NPR1(4), NPR2(4), PLA2G10(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(2), PLCB1(1), PLCB2(2), PLCB3(2), PLCB4(4), PPP2CA(1), PPP2CB(1), PPP2R1A(1), PPP2R1B(1), PPP2R2A(3), PPP2R2B(3), PPP2R2C(1), PRKCA(2), PRKCG(2), PRKG1(3), PRKG2(2), RAF1(1), RYR1(13) 72272749 152 115 150 44 24 16 9 61 41 1 0.548 1.000 1.000 561 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 126 BID(1), BRAF(2), CD48(1), FAS(1), FYN(2), GRB2(2), HCST(1), HLA-B(1), HLA-C(2), HLA-E(2), HRAS(1), ICAM1(1), IFNA1(1), IFNA14(1), IFNA16(1), IFNA21(2), IFNA5(1), IFNA7(1), IFNA8(2), IFNAR1(2), IFNB1(2), IFNGR1(2), IFNGR2(2), ITGAL(5), ITGB2(1), KIR2DL3(1), KIR3DL1(3), KLRC1(2), KLRC2(3), KLRC3(1), KRAS(1), LCP2(1), MAPK3(1), MICA(1), MICB(2), NCR1(1), NFAT5(6), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), PAK1(2), PIK3CA(10), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PLCG1(2), PLCG2(2), PPP3CA(2), PPP3CC(3), PRF1(1), PRKCA(2), PRKCG(2), PTK2B(3), PTPN11(1), PTPN6(3), RAC3(1), RAF1(1), SH2D1B(1), SH3BP2(2), SHC1(3), SHC2(1), SOS1(5), SOS2(3), SYK(1), TNFRSF10C(1), TNFSF10(6), ULBP2(1), VAV1(3), VAV2(4) 72635902 158 114 147 36 8 28 17 57 47 1 0.235 1.000 1.000 562 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 161 ADORA2A(1), ADORA2B(1), ADRA1A(4), ADRB2(2), AGTR1(2), AVPR1A(1), AVPR2(2), BDKRB1(1), BDKRB2(1), BRS3(1), C3AR1(1), CCKAR(2), CCKBR(1), CCR6(1), CCR9(1), CHML(1), CHRM2(3), CHRM3(2), CHRM5(2), CMKLR1(1), CNR1(1), CNR2(2), CX3CR1(1), CXCR4(1), DRD1(1), DRD2(1), DRD3(2), DRD5(1), EDNRB(3), F2RL1(1), F2RL2(1), FPR1(2), FSHR(2), GALR1(1), GALT(3), GPR17(2), GPR173(1), GPR174(2), GPR35(2), GPR37(1), GPR37L1(1), GPR4(1), GPR50(1), GPR63(1), GPR83(1), GPR85(2), GPR87(1), GRPR(1), HRH2(1), HTR1A(2), HTR1D(2), HTR1E(3), HTR1F(1), HTR2A(1), HTR2C(1), HTR4(1), HTR6(1), HTR7(2), MAS1(1), MC1R(2), MC3R(2), MC4R(1), MC5R(1), MTNR1B(1), NMUR2(4), NTSR1(1), OPN1SW(2), OPRD1(2), OPRL1(1), OPRM1(3), OR12D3(1), OR1C1(1), OR1F1(1), OR5V1(2), OR7A5(1), OR7C1(2), OR8B8(2), P2RY1(1), P2RY10(1), P2RY11(1), P2RY12(1), P2RY13(1), P2RY14(1), P2RY2(1), PTAFR(1), PTGER2(1), PTGER4(1), PTGFR(3), PTGIR(1), RHO(1), SSTR1(1), SSTR3(1), SSTR4(1), TBXA2R(2), TRHR(2) 74811985 139 110 137 46 23 19 15 55 27 0 0.496 1.000 1.000 563 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 107 A4GNT(2), ALG1(1), ALG10(3), ALG10B(6), ALG11(3), ALG12(2), ALG13(4), ALG14(1), ALG3(2), ALG6(2), ALG8(1), B3GNT1(1), B3GNT2(3), B3GNT6(1), B3GNT7(1), B4GALT3(2), B4GALT4(2), B4GALT5(1), CHST1(2), CHST11(1), CHST12(2), CHST14(1), CHST2(1), CHST4(1), CHST7(1), CHSY1(8), DPAGT1(5), EXT1(3), EXT2(1), EXTL1(1), EXTL2(7), EXTL3(3), FUT11(1), GALNT1(1), GALNT10(5), GALNT11(2), GALNT13(3), GALNT14(1), GALNT2(1), GALNT4(1), GALNT5(5), GALNT6(1), GALNT7(5), GALNT9(1), GALNTL5(2), GCNT1(2), GCNT4(1), HS2ST1(1), HS3ST2(1), HS3ST5(1), HS6ST1(1), HS6ST2(1), MAN1A1(2), MAN1A2(1), MAN2A1(3), MGAT4A(3), MGAT4B(1), MGAT5(3), MGAT5B(2), NDST1(2), NDST2(3), NDST4(5), OGT(4), RPN1(2), RPN2(1), ST3GAL1(1), ST3GAL3(3), ST3GAL4(1), ST6GALNAC1(2), STT3B(3), WBSCR17(3), XYLT1(2), XYLT2(2) 70053130 161 109 144 41 5 26 13 52 65 0 0.551 1.000 1.000 564 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(4), AMY2A(1), AMY2B(1), ASCC3(5), ATP13A2(4), DDX18(3), DDX23(2), DDX4(3), DDX50(5), DDX52(1), DDX54(1), DDX55(2), DHX58(1), ENPP3(1), EP400(8), ERCC2(1), ERCC3(1), G6PC(3), GAA(1), GANC(2), GBA(2), GPI(3), GUSB(5), GYS1(3), GYS2(1), HK1(5), IFIH1(1), MGAM(5), MOV10L1(5), NUDT5(3), PYGB(2), PYGL(1), PYGM(3), RAD54L(2), RUVBL2(2), SETX(7), SI(6), SMARCA2(5), SMARCA5(1), UGP2(1), UGT1A1(3), UGT1A4(2), UGT1A5(1), UGT1A6(3), UGT1A7(3), UGT2A1(3), UGT2A3(2), UGT2B11(2), UGT2B15(1), UGT2B28(3), UGT2B4(2), UGT2B7(3), UXS1(1) 81764248 142 107 136 47 7 22 18 42 53 0 0.866 1.000 1.000 565 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(6), ABCA10(4), ABCA12(7), ABCA13(17), ABCA2(2), ABCA3(3), ABCA4(7), ABCA5(5), ABCA6(3), ABCA7(7), ABCA8(4), ABCA9(3), ABCB1(4), ABCB11(3), ABCB4(5), ABCB5(3), ABCB6(1), ABCB8(1), ABCC1(8), ABCC10(4), ABCC11(5), ABCC12(2), ABCC2(1), ABCC3(7), ABCC4(5), ABCC5(2), ABCC6(5), ABCC8(4), ABCC9(3), ABCD2(1), ABCD3(2), ABCD4(3), ABCG1(1), ABCG4(5), ABCG5(2), ABCG8(3), CFTR(4), TAP2(1) 77455409 153 106 142 38 6 24 19 60 43 1 0.239 1.000 1.000 566 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 82 ACVR1(1), ACVR1B(3), AKT1(1), BMPR2(5), CDKL1(1), CDS2(1), CLK1(4), CLK2(2), CLK4(3), COL4A3BP(2), CSNK2A2(1), CSNK2B(1), DGKA(2), DGKB(1), DGKD(1), DGKE(3), DGKG(2), DGKH(3), DGKQ(1), DGKZ(2), INPP4A(2), INPP4B(2), INPP5A(1), INPPL1(2), ITPKB(2), MAP3K10(3), MOS(1), NEK1(3), NEK3(3), OCRL(2), PAK4(2), PIK3C2A(3), PIK3C2B(2), PIK3C2G(2), PIK3CA(10), PIK3CB(3), PIK3CG(3), PLCB1(1), PLCB2(2), PLCB3(2), PLCB4(4), PLCD1(1), PLCG1(2), PLCG2(2), PLK3(1), PRKACA(1), PRKACB(2), PRKACG(2), PRKAR1A(2), PRKAR2B(2), PRKCA(2), PRKCD(3), PRKCE(2), PRKCG(2), PRKCH(4), PRKCQ(4), PRKCZ(1), PRKD1(3), PRKG1(3), RAF1(1), RPS6KA1(7), RPS6KA4(1), RPS6KB1(2) 74646129 145 106 136 32 10 23 7 50 54 1 0.235 1.000 1.000 567 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 82 ABL1(4), ATM(15), BUB1B(1), BUB3(1), CCNA1(7), CCNB2(5), CCNB3(4), CCND2(1), CCNE1(1), CCNE2(2), CCNH(1), CDAN1(4), CDC14A(5), CDC20(1), CDC25A(1), CDC25B(1), CDC25C(2), CDC6(1), CDC7(1), CDH1(1), CDK2(2), CDK4(6), CDKN1A(1), CDKN2A(3), CHEK2(1), DTX4(4), E2F1(1), E2F5(1), EP300(11), ESPL1(7), GSK3B(3), HDAC1(2), HDAC4(1), HDAC6(2), MAD2L1(1), MCM2(6), MCM5(2), MCM6(3), MCM7(5), PCNA(2), PRKDC(10), PTPRA(3), RB1(2), SKP2(1), SMAD4(1), TBC1D8(1), TP53(15), WEE1(1) 73140385 157 99 143 36 9 19 22 47 57 3 0.135 1.000 1.000 568 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CD2BP2(1), CDC40(1), CLK2(2), CLK3(1), CLK4(3), COL2A1(5), CPSF1(3), CPSF2(2), CPSF3(4), CPSF4(2), CSTF2T(1), CSTF3(4), DDX1(1), DDX20(4), DHX15(2), DHX16(1), DHX8(2), DHX9(3), DICER1(3), FUS(5), GIPC1(1), METTL3(4), NONO(2), NUDT21(1), NXF1(1), PAPOLA(2), POLR2A(8), PPM1G(1), PRPF3(2), PRPF4B(3), PRPF8(11), PSKH1(1), PTBP1(1), PTBP2(1), RBM17(1), RBM5(1), RNMT(1), SF3A1(1), SF3A3(1), SF3B1(7), SF3B2(2), SNRPB(1), SNRPN(2), SPOP(1), SRPK2(2), SRRM1(2), SUPT5H(4), TXNL4A(1), U2AF2(2), XRN2(2) 69462013 120 98 117 31 8 29 9 41 32 1 0.347 1.000 1.000 569 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 74 AKT1(1), AKT2(3), AKT3(1), FYN(2), GAB2(1), GRB2(2), HRAS(1), IL3(1), IL4(1), INPP5D(2), KRAS(1), LCP2(1), MAP2K3(2), MAP2K7(1), MAPK10(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK9(2), MS4A2(1), PDK1(1), PIK3CA(10), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PLA2G10(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(2), PLCG1(2), PLCG2(2), PRKCA(2), PRKCD(3), PRKCE(2), RAC3(1), RAF1(1), SOS1(5), SOS2(3), SYK(1), VAV1(3), VAV2(4) 47420285 87 77 82 26 7 19 13 33 15 0 0.399 1.000 1.000 570 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 69 AKT1(1), AKT2(3), AKT3(1), CASP9(1), CDC42(1), HRAS(1), KDR(5), KRAS(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPKAPK2(1), NFAT5(6), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), NOS3(2), PIK3CA(10), PIK3CB(3), PIK3CD(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PLA2G10(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(2), PLCG1(2), PLCG2(2), PPP3CA(2), PPP3CC(3), PRKCA(2), PRKCG(2), PTGS2(4), PTK2(1), PXN(1), RAC3(1), RAF1(1), SH2D2A(1), SHC2(1), SPHK2(1), SRC(1) 46331947 96 76 89 29 6 17 9 41 23 0 0.599 1.000 1.000 571 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(2), ALPL(2), ALPP(3), ALPPL2(3), ASCC3(5), ATP13A2(4), DDX18(3), DDX23(2), DDX4(3), DDX50(5), DDX52(1), DDX54(1), DDX55(2), DHX58(1), EP400(8), ERCC2(1), ERCC3(1), FPGS(2), IFIH1(1), MOV10L1(5), NUDT5(3), QDPR(1), RAD54L(2), RUVBL2(2), SETX(7), SMARCA2(5), SMARCA5(1) 40685480 76 64 73 22 2 16 9 21 28 0 0.502 1.000 1.000 572 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 65 ADAM10(4), ATP6AP1(2), ATP6V0A1(2), ATP6V0A2(2), ATP6V0A4(1), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(2), ATP6V1B2(2), ATP6V1D(1), ATP6V1G1(1), CDC42(1), CHUK(1), CSK(3), EGFR(9), F11R(1), GIT1(1), IGSF5(4), IKBKB(1), JAM3(1), JUN(2), MAPK10(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK9(2), MET(6), NFKB1(1), NFKB2(1), NOD1(1), PAK1(2), PLCG1(2), PLCG2(2), PTPN11(1), PTPRZ1(9), RELA(5), SRC(1), TJP1(2) 46433030 85 64 75 20 6 12 9 31 26 1 0.481 1.000 1.000 573 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 ACTG1(3), APAF1(2), ARHGDIB(1), BAG4(1), BID(1), BIRC2(2), BIRC3(2), CASP2(1), CASP7(1), CASP8(1), CASP9(1), CFLAR(1), CHUK(1), DAXX(5), DFFB(1), GSN(2), LMNB1(3), MAP2K7(1), MAP3K1(5), MAP3K5(5), NFKB1(1), NUMA1(3), PAK2(2), PRKCD(3), PRKDC(10), PSEN2(2), PTK2(1), RASA1(3), RB1(2), RELA(5), RIPK1(1), SPTAN1(6), TNFRSF1A(1), TRADD(2), TRAF2(1) 45462088 83 63 80 19 3 17 10 28 24 1 0.160 1.000 1.000 574 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(5), ATP4A(5), ATP5A1(2), ATP5B(2), ATP5C1(1), ATP5G2(1), ATP6AP1(2), ATP6V0A1(2), ATP6V0A2(2), ATP6V0A4(1), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(2), ATP6V1B2(2), ATP6V1D(1), ATP6V1G1(1), COX10(2), COX15(1), COX17(1), COX6B2(1), CYC1(1), NDUFA1(1), NDUFA10(1), NDUFA13(2), NDUFA3(1), NDUFA6(1), NDUFB2(1), NDUFB6(1), NDUFC1(2), NDUFS1(5), NDUFS2(1), NDUFS3(2), NDUFS5(1), NDUFS6(1), NDUFS8(1), NDUFV1(1), NDUFV2(1), PPA2(2), SDHA(1), SDHB(1), SDHD(1), UQCRC1(1), UQCRC2(1), UQCRFS1(1) 36695426 71 61 70 22 5 10 9 29 18 0 0.702 1.000 1.000 575 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 ANKHD1(9), EEF1A2(1), EEF1G(1), EEF2K(1), EIF2AK1(1), EIF2AK2(4), EIF2AK3(2), EIF2B1(1), EIF2B2(1), EIF2B3(1), EIF2B5(2), EIF2S2(2), EIF4A2(3), EIF4E(1), EIF4G1(3), EIF4G3(3), EIF5(2), EIF5A(2), ETF1(2), PABPC1(9), PABPC3(7), PAIP1(3), SLC35A4(2) 28841964 63 56 63 23 7 11 6 23 16 0 0.831 1.000 1.000 576 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 58 APC(7), AXIN1(2), CCND2(1), CTNNB1(1), DVL1(1), DVL2(1), FZD1(1), FZD10(3), FZD2(2), FZD3(1), FZD5(1), GSK3B(3), JUN(2), LDLR(1), MAPK10(1), MAPK9(2), PAFAH1B1(1), PRKCA(2), PRKCD(3), PRKCE(2), PRKCG(2), PRKCH(4), PRKCI(2), PRKCQ(4), PRKCZ(1), PRKD1(3), SFRP4(2), WNT10A(1), WNT11(1), WNT2(1), WNT3(1), WNT5B(1), WNT7B(1) 37193972 62 56 59 21 5 13 6 20 18 0 0.716 1.000 1.000 577 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(4), AMY2A(1), AMY2B(1), ENPP3(1), G6PC(3), GAA(1), GPI(3), GUSB(5), GYS1(3), GYS2(1), HK1(5), MGAM(5), PYGB(2), PYGL(1), PYGM(3), RNPC3(1), SI(6), UCHL3(1), UGT1A1(3), UGT1A4(2), UGT1A5(1), UGT1A6(3), UGT1A7(3), UGT2B15(1), UGT2B4(2), UXS1(1) 37840880 63 53 60 20 5 9 8 19 22 0 0.746 1.000 1.000 578 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(4), ACTB(1), ACTG1(3), ARHGEF2(1), ARPC5L(1), CDC42(1), CDH1(1), CTNNB1(1), EZR(1), FYN(2), HCLS1(1), ITGB1(4), LY96(1), NCK1(1), NCL(3), OCLN(2), PRKCA(2), ROCK1(4), ROCK2(2), TLR4(2), TLR5(2), TUBA1A(2), TUBA3C(1), TUBA3D(1), TUBA4A(4), TUBAL3(3), TUBB(2), TUBB1(2), TUBB2B(2), WASL(6) 33048574 63 52 62 23 3 14 9 21 16 0 0.856 1.000 1.000 579 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(4), ACTB(1), ACTG1(3), ARHGEF2(1), ARPC5L(1), CDC42(1), CDH1(1), CTNNB1(1), EZR(1), FYN(2), HCLS1(1), ITGB1(4), LY96(1), NCK1(1), NCL(3), OCLN(2), PRKCA(2), ROCK1(4), ROCK2(2), TLR4(2), TLR5(2), TUBA1A(2), TUBA3C(1), TUBA3D(1), TUBA4A(4), TUBAL3(3), TUBB(2), TUBB1(2), TUBB2B(2), WASL(6) 33048574 63 52 62 23 3 14 9 21 16 0 0.856 1.000 1.000 580 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 AGMAT(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH2(2), ALDH4A1(1), AOC2(3), AOC3(1), ARG1(1), ASL(4), CPS1(4), DAO(1), GATM(1), GOT1(3), GOT2(2), MAOA(1), NOS1(9), NOS3(2), OAT(1), ODC1(2), OTC(1), P4HA1(3), P4HA2(1), PYCR1(1), RARS(2), SMS(2) 28582659 55 50 53 18 3 5 11 17 19 0 0.800 1.000 1.000 581 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(2), AARS2(2), CARS(6), CARS2(3), DARS(1), DARS2(1), EPRS(2), FARSA(1), HARS(1), HARS2(1), IARS(4), IARS2(2), LARS(3), LARS2(2), MARS(2), MARS2(3), NARS2(4), PARS2(3), QARS(1), RARS(2), SARS(2), TARS(5), TARS2(5), VARS(2), VARS2(2), WARS(1), WARS2(1), YARS(1) 34829011 65 50 61 16 1 11 7 27 19 0 0.458 1.000 1.000 582 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F11(1), F12(3), F13B(2), F2(2), F5(7), F7(1), F8(5), F9(2), FGA(2), FGB(1), FGG(5), LPA(6), PLAT(4), PLG(5), SERPINF2(2), VWF(11) 22827589 59 49 55 19 4 3 11 20 19 2 0.681 1.000 1.000 583 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 63 ACHE(1), CDS2(1), CHAT(4), CHKB(2), CHPT1(2), DGKA(2), DGKB(1), DGKD(1), DGKE(3), DGKG(2), DGKH(3), DGKI(1), DGKQ(1), DGKZ(2), ESCO1(2), ESCO2(1), ETNK1(2), GPAM(2), LCAT(1), LYPLA1(1), PCYT1A(1), PISD(1), PLA2G10(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(2), PLD1(2), PLD2(5), PNPLA3(2), PPAP2B(1), PPAP2C(2), PTDSS1(2), SH3GLB1(2) 42731591 58 48 54 15 8 7 4 17 22 0 0.511 1.000 1.000 584 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 ALDH1A1(1), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH2(2), AOC2(3), AOC3(1), AOX1(7), CAT(2), CYP19A1(2), CYP1A1(1), CYP1A2(3), CYP2A13(3), CYP2B6(1), CYP2C18(1), CYP2C19(1), CYP2E1(1), CYP2F1(1), CYP2J2(3), CYP3A7(1), CYP4B1(3), DDC(2), ECHS1(2), EHHADH(5), GCDH(3), HAAO(1), HADHA(2), MAOA(1), TPH1(1), WARS(1), WARS2(1) 35913132 61 48 56 21 6 10 7 20 18 0 0.795 1.000 1.000 585 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 CALM2(1), ELK1(1), FOS(1), GRB2(2), HRAS(1), JUN(2), MAP3K1(5), MAPK14(1), MAPK3(1), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), PLCG1(2), PPP3CA(2), PPP3CC(3), PRKCA(2), RAF1(1), SHC1(3), SOS1(5), SYK(1), SYT1(1), VAV1(3) 24547456 53 46 50 19 6 8 4 16 19 0 0.876 1.000 1.000 586 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR1(2), ATP8A1(2), AVPR1A(1), AVPR2(2), BDKRB1(1), BDKRB2(1), BRS3(1), C3AR1(1), CCKAR(2), CCKBR(1), CCR6(1), CX3CR1(1), CXCR4(1), CXCR6(1), EDNRB(3), FPR1(2), FSHR(2), GALR1(1), GALT(3), GRPR(1), MC1R(2), MC2R(2), MC3R(2), MC4R(1), MC5R(1), NTSR1(1), OPRD1(2), OPRL1(1), OPRM1(3), SSTR1(1), SSTR3(1), SSTR4(1), TACR1(1), TACR3(2), TRHR(2), TSHR(2) 32739361 55 44 55 18 13 7 6 19 10 0 0.437 1.000 1.000 587 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(5), CREBBP(5), EP300(11), ERCC3(1), GRIP1(1), GTF2A1(1), GTF2E1(1), GTF2F1(1), HDAC1(2), HDAC4(1), HDAC6(2), NCOR2(6), NRIP1(4), PELP1(1), POLR2A(8), TBP(1) 30162873 51 43 48 16 2 6 8 17 18 0 0.643 1.000 1.000 588 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 INPP4A(2), INPP4B(2), INPP5A(1), INPPL1(2), ITPKB(2), MIOX(2), OCRL(2), PIK3C2A(3), PIK3C2B(2), PIK3C2G(2), PIK3CA(10), PIK3CB(3), PIK3CG(3), PLCB1(1), PLCB2(2), PLCB3(2), PLCB4(4), PLCD1(1), PLCG1(2), PLCG2(2) 29634825 50 43 46 15 1 7 3 22 17 0 0.827 1.000 1.000 589 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 ALOX12(2), ALOX15B(2), ALOX5(2), CBR1(2), CYP2B6(1), CYP2C18(1), CYP2C19(1), CYP2E1(1), CYP2J2(3), CYP2U1(1), CYP4A11(4), CYP4F2(2), DHRS4(3), EPHX2(1), GGT1(2), GPX6(1), LTA4H(4), PLA2G10(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(2), PTGDS(1), PTGS1(2), PTGS2(4), TBXAS1(3) 25276434 48 42 46 14 4 6 12 12 13 1 0.483 1.000 1.000 590 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 ACTR2(1), AKT1(1), DGKA(2), GCA(2), ITGA9(1), ITPKB(2), ITPR1(4), ITPR2(9), ITPR3(4), MAPK3(1), NR1I3(1), PAK1(2), PDE3A(3), PDE3B(1), PIK3C2G(2), PIK3CA(10), PIK3CD(1), PIK3R1(2) 32164513 49 42 46 13 6 11 5 17 10 0 0.247 1.000 1.000 591 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 B3GNT6(1), B4GALT5(1), GALNT1(1), GALNT10(5), GALNT11(2), GALNT13(3), GALNT14(1), GALNT2(1), GALNT4(1), GALNT5(5), GALNT6(1), GALNT7(5), GALNT9(1), GALNTL5(2), GCNT1(2), GCNT4(1), OGT(4), ST3GAL1(1), ST6GALNAC1(2), WBSCR17(3) 21376454 43 41 40 18 1 5 6 19 12 0 0.962 1.000 1.000 592 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(1), AGPS(1), CDS2(1), CHAT(4), CHKB(2), CLC(2), DGKA(2), DGKB(1), DGKD(1), DGKE(3), DGKG(2), DGKH(3), DGKQ(1), DGKZ(2), ETNK1(2), LCAT(1), LYPLA1(1), PAFAH1B1(1), PAFAH2(1), PCYT1A(1), PISD(1), PLA2G4A(1), PLA2G6(2), PLCB2(2), PLCG1(2), PLCG2(2), PPAP2B(1), PPAP2C(2) 32534496 46 39 43 17 6 9 2 11 18 0 0.803 1.000 1.000 593 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(4), AR(1), ESR2(2), NR1D2(1), NR1H3(2), NR1I2(1), NR1I3(1), NR2C2(1), NR2F2(2), NR4A2(1), NR5A2(2), PGR(2), PPARD(1), PPARG(2), RARA(4), RARB(2), RORA(2), RORC(1), RXRB(4), RXRG(2), THRA(1), VDR(1) 26236564 40 38 40 15 6 3 9 13 9 0 0.810 1.000 1.000 594 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(3), ACTG2(1), ADCY3(3), ADCY9(4), ARF1(1), ARF3(1), ARF6(1), ARL4D(1), ATP6V0A1(2), ATP6V0A2(2), ATP6V0A4(1), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1D(1), ATP6V1G1(1), GNAS(5), PLCG1(2), PLCG2(2), PRKCA(2), SEC61B(1), TRIM23(3) 24292078 42 37 41 14 1 6 5 16 14 0 0.881 1.000 1.000 595 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 20 ELK1(1), FOS(1), GRB2(2), HRAS(1), IL6R(2), IL6ST(3), JAK1(4), JAK2(5), JAK3(3), JUN(2), MAPK3(1), PTPN11(1), RAF1(1), SHC1(3), SOS1(5), STAT3(3) 15363821 38 35 38 13 3 4 6 15 10 0 0.860 1.000 1.000 596 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 BCAR1(3), CXCR4(1), GNAI1(1), GNB1(2), HRAS(1), MAPK3(1), NFKB1(1), PIK3C2G(2), PIK3CA(10), PIK3R1(2), PLCG1(2), PRKCA(2), PTK2(1), PTK2B(3), PXN(1), RAF1(1), RELA(5) 18409884 39 34 32 15 1 10 2 15 10 1 0.890 1.000 1.000 597 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(3), ALDOA(1), ALDOB(3), FPGT(1), GMDS(1), GMPPA(1), GMPPB(1), HK1(5), KHK(3), MPI(1), PFKFB3(1), PFKM(3), PFKP(2), SORD(10), TPI1(1) 15651531 37 34 30 12 5 2 4 6 20 0 0.913 1.000 1.000 598 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(3), CALM2(1), GRB2(2), HRAS(1), JUN(2), MAP2K3(2), MAP3K1(5), MAPK14(1), MAPK3(1), PAK1(2), PLCG1(2), PRKCA(2), PTK2B(3), RAF1(1), SHC1(3), SOS1(5), SRC(1), SYT1(1) 18578940 38 34 37 12 3 8 1 15 11 0 0.813 1.000 1.000 599 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 DLG4(1), EPHB2(2), F2(2), F2RL1(1), F2RL2(1), JUN(2), MAP2K5(1), MAPK7(1), PLD1(2), PLD2(5), PLD3(3), PTK2(1), RAF1(1), RASAL1(5), SRC(1), TEC(5), VAV1(3) 17863193 37 34 32 12 4 1 3 16 13 0 0.923 1.000 1.000 600 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(3), G6PC(3), GAA(1), GALK1(1), GALK2(1), GALT(3), GLA(1), GLB1(5), HK1(5), LALBA(1), LCT(2), MGAM(5), PFKM(3), PFKP(2) 21050291 36 33 35 13 3 5 4 9 15 0 0.843 1.000 1.000 601 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 ADCY1(2), AKT1(1), ASAH1(1), GNAI1(1), GNB1(2), ITGAV(1), ITGB3(1), MAPK3(1), PDGFRA(5), PIK3CA(10), PIK3R1(2), PLCB1(1), PRKCA(2), PTK2(1), SMPD2(2), SRC(1) 18022500 34 31 31 14 2 10 3 12 7 0 0.856 1.000 1.000 602 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP1(1), ACP2(1), ACP5(2), ALPI(2), ALPL(2), ALPP(3), ALPPL2(3), CYP19A1(2), CYP1A1(1), CYP1A2(3), CYP2A13(3), CYP2B6(1), CYP2C18(1), CYP2C19(1), CYP2E1(1), CYP2F1(1), CYP2J2(3), CYP3A7(1), CYP4B1(3) 18605266 35 31 35 11 6 8 1 14 6 0 0.472 1.000 1.000 603 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 ELK1(1), FOS(1), GRB2(2), HRAS(1), IL2RA(2), IL2RB(2), JAK1(4), JAK3(3), JUN(2), MAPK3(1), RAF1(1), SHC1(3), SOS1(5), STAT5A(2), STAT5B(2), SYK(1) 15080632 33 31 32 11 4 5 4 11 9 0 0.764 1.000 1.000 604 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL22RA1(1), IL22RA2(1), JAK1(4), JAK2(5), JAK3(3), SOCS3(1), STAT1(3), STAT3(3), STAT5A(2), STAT5B(2), TYK2(6) 11937463 31 30 29 12 1 0 5 12 13 0 0.977 1.000 1.000 605 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 31 ADRA1A(4), ADRB2(2), CHRM2(3), CHRM3(2), CHRM5(2), DRD1(1), DRD2(1), DRD3(2), DRD5(1), HRH2(1), HTR1A(2), HTR1D(2), HTR1E(3), HTR1F(1), HTR2A(1), HTR2C(1), HTR4(1), HTR6(1), HTR7(2) 15949244 33 30 31 15 5 3 2 14 9 0 0.908 1.000 1.000 606 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CFL1(1), GNAS(5), GNB1(2), HRAS(1), LIMK1(4), MAPK3(1), MYL2(1), NOX1(6), PIK3C2G(2), PLCB1(1), PPP1R12B(1), PRKCA(2), PTK2(1), RAF1(1), ROCK2(2) 16827317 31 28 27 11 1 2 1 15 12 0 0.975 1.000 1.000 607 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA3(2), ANXA4(2), ANXA6(2), CYP11A1(1), EDNRB(3), HPGD(1), PLA2G4A(1), PTGDS(1), PTGER2(1), PTGER4(1), PTGFR(3), PTGIR(1), PTGS1(2), PTGS2(4), TBXAS1(3) 13322619 28 28 28 14 2 4 4 10 7 1 0.953 1.000 1.000 608 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTN1(1), ACTN2(3), CAPN1(1), ITGA1(5), ITGB1(4), ITGB3(1), PTK2(1), PXN(1), SPTAN1(6), SRC(1), TLN1(6) 18685380 30 28 29 12 2 3 1 12 12 0 0.954 1.000 1.000 609 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 17 CALM2(1), CDKN1A(1), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(3), PLCG1(2), PPP3CA(2), PPP3CC(3), PRKCA(2), SP1(2), SP3(2), SYT1(1) 13047876 31 27 28 11 2 5 2 7 15 0 0.901 1.000 1.000 610 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(6), LCAT(1), LDLR(1), LIPC(1), LPL(2), LRP1(11), SCARB1(1), SOAT1(4) 17613083 27 26 25 10 2 5 3 7 10 0 0.758 1.000 1.000 611 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(2), GNAI1(1), GNB1(2), HRAS(1), ITGA1(5), ITGB1(4), MAPK3(1), PLA2G4A(1), PLCB1(1), PRKCA(2), PTGS1(2), PTK2(1), RAF1(1), SRC(1), SYK(1), TBXAS1(3) 16063605 29 25 28 15 2 4 3 8 11 1 0.984 1.000 1.000 612 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(1), ACTN2(3), BCAR1(3), CSK(3), CTNNA1(4), CTNNA2(4), CTNNB1(1), PTK2(1), PXN(1), SRC(1), VCL(2) 12436358 24 23 24 13 3 3 3 12 3 0 0.973 1.000 1.000 613 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(1), GALNT10(5), GALNT2(1), GALNT4(1), GALNT6(1), GALNT7(5), GALNT9(1), GCNT1(2), ST3GAL1(1), ST3GAL4(1), WBSCR17(3) 9626314 22 22 19 14 0 1 5 6 10 0 0.998 1.000 1.000 614 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), HS3ST2(1), XYLT1(2), XYLT2(2) 3749783 6 6 6 5 1 3 0 2 0 0 0.859 1.000 1.000 615 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), HS3ST2(1), XYLT1(2), XYLT2(2) 3749783 6 6 6 5 1 3 0 2 0 0 0.859 1.000 1.000 616 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 341605 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000