E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.095 0.188 -9999.0 0.0 -0.475 28.0 28.0 KLHL20 -0.04 0.098 -9999.0 0.0 -0.196 35.0 35.0 CYFIP2 0.013 0.043 -9999.0 0.0 -0.381 2.0 2.0 Rac1/GDP -0.038 0.117 -9999.0 0.0 -0.244 28.0 28.0 ENAH -0.092 0.173 -9999.0 0.0 -0.433 29.0 29.0 AP1M1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.05 0.073 -9999.0 0.0 -0.245 13.0 13.0 ABI1/Sra1/Nap1 -0.05 0.061 -9999.0 0.0 -0.149 40.0 40.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.03 0.101 -9999.0 0.0 -0.199 32.0 32.0 RAPGEF1 -0.059 0.15 -9999.0 0.0 -0.351 30.0 30.0 CTNND1 0.008 0.06 -9999.0 0.0 -0.381 4.0 4.0 regulation of calcium-dependent cell-cell adhesion -0.068 0.167 -9999.0 0.0 -0.413 29.0 29.0 CRK -0.069 0.162 -9999.0 0.0 -0.384 30.0 30.0 E-cadherin/gamma catenin/alpha catenin -0.064 0.126 -9999.0 0.0 -0.196 74.0 74.0 alphaE/beta7 Integrin 0.011 0.056 -9999.0 0.0 -0.199 11.0 11.0 IQGAP1 0.015 0.03 -9999.0 0.0 -0.381 1.0 1.0 NCKAP1 -0.046 0.132 -9999.0 0.0 -0.313 33.0 33.0 Rap1/GTP/I-afadin 0.004 0.065 -9999.0 0.0 -0.186 9.0 9.0 DLG1 -0.06 0.162 -9999.0 0.0 -0.403 28.0 28.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.036 0.054 -9999.0 0.0 -0.188 11.0 11.0 MLLT4 -0.037 0.121 -9999.0 0.0 -0.298 30.0 30.0 ARF6/GTP/NME1/Tiam1 0.003 0.068 -9999.0 0.0 -0.172 15.0 15.0 PI3K -0.045 0.068 -9999.0 0.0 -0.242 11.0 11.0 ARF6 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.083 0.142 -9999.0 0.0 -0.239 71.0 71.0 TIAM1 -0.04 0.126 -9999.0 0.0 -0.31 30.0 30.0 E-cadherin(dimer)/Ca2+ -0.028 0.093 -9999.0 0.0 -0.179 34.0 34.0 AKT1 -0.023 0.042 -9999.0 0.0 -0.141 10.0 10.0 PIK3R1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.098 0.163 -9999.0 0.0 -0.319 59.0 59.0 RhoA/GDP -0.037 0.117 -9999.0 0.0 -0.245 27.0 27.0 actin cytoskeleton organization -0.028 0.073 -9999.0 0.0 -0.144 35.0 35.0 CDC42/GDP -0.037 0.117 -9999.0 0.0 -0.243 28.0 28.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.057 0.117 -9999.0 0.0 -0.226 46.0 46.0 ITGB7 0.005 0.066 -9999.0 0.0 -0.342 6.0 6.0 RAC1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin -0.03 0.1 -9999.0 0.0 -0.191 34.0 34.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.032 0.087 -9999.0 0.0 -0.18 31.0 31.0 mol:GDP -0.052 0.131 -9999.0 0.0 -0.269 35.0 35.0 CDC42/GTP/IQGAP1 0.022 0.018 -9999.0 0.0 -0.214 1.0 1.0 JUP -0.026 0.123 -9999.0 0.0 -0.375 19.0 19.0 p120 catenin/RhoA/GDP -0.038 0.12 -9999.0 0.0 -0.253 27.0 27.0 RAC1/GTP/IQGAP1 0.022 0.018 -9999.0 0.0 -0.214 1.0 1.0 PIP5K1C/AP1M1 0.026 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.008 0.06 -9999.0 0.0 -0.381 4.0 4.0 positive regulation of S phase of mitotic cell cycle -0.027 0.068 -9999.0 0.0 -0.129 41.0 41.0 NME1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.084 0.166 -9999.0 0.0 -0.415 29.0 29.0 regulation of cell-cell adhesion -0.045 0.065 -9999.0 0.0 -0.216 13.0 13.0 WASF2 -0.024 0.033 -9999.0 0.0 -0.098 13.0 13.0 Rap1/GTP -0.033 0.103 -9999.0 0.0 -0.274 14.0 14.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.046 0.12 -9999.0 0.0 -0.212 46.0 46.0 CCND1 -0.033 0.082 -9999.0 0.0 -0.158 41.0 41.0 VAV2 -0.103 0.217 -9999.0 0.0 -0.457 40.0 40.0 RAP1/GDP -0.035 0.108 -9999.0 0.0 -0.279 14.0 14.0 adherens junction assembly -0.082 0.161 -9999.0 0.0 -0.402 29.0 29.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.039 0.114 -9999.0 0.0 -0.298 15.0 15.0 E-cadherin/beta catenin -0.052 0.111 -9999.0 0.0 -0.285 28.0 28.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.079 0.171 -9999.0 0.0 -0.402 32.0 32.0 PIK3CA 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.096 0.131 -9999.0 0.0 -0.318 35.0 35.0 E-cadherin/beta catenin/alpha catenin -0.039 0.103 -9999.0 0.0 -0.214 31.0 31.0 ITGAE 0.009 0.047 -9999.0 0.0 -0.262 5.0 5.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.069 0.17 -9999.0 0.0 -0.429 28.0 28.0