rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 30 ANPEP(3), G6PD(2), GCLC(1), GGT1(2), GPX2(2), GSS(1), GSTA1(1), GSTA2(1), GSTA3(1), GSTA4(1), GSTM4(1), GSTM5(1), GSTT1(1), GSTZ1(3), IDH1(398), IDH2(20), PGD(1) 13770087 440 422 27 13 384 16 7 29 4 0 1.22e-15 <1.00e-15 <3.08e-14 2 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 36 ANPEP(3), G6PD(2), GCLC(1), GGT1(2), GPX2(2), GPX6(1), GSS(1), GSTA1(1), GSTA2(1), GSTA3(1), GSTA4(1), GSTA5(3), GSTK1(1), GSTM4(1), GSTM5(1), GSTT1(1), GSTZ1(3), IDH1(398), IDH2(20), OPLAH(2) 16786375 446 422 33 14 386 20 7 30 3 0 <1.00e-15 <1.00e-15 <3.08e-14 3 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(3), ACO1(5), ACO2(4), ACSS1(1), ACSS2(4), FH(1), IDH1(398), IDH2(20) 10145121 436 421 23 1 384 16 4 29 3 0 <1.00e-15 <1.00e-15 <3.08e-14 4 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(3), ACO1(5), ACO2(4), CLYBL(1), DLD(1), FH(1), IDH1(398), IDH2(20), IDH3B(1), OGDH(1), OGDHL(4), PC(2), PCK1(3), SDHA(4), SDHC(2), SUCLG2(1) 22764387 451 420 37 8 388 18 9 32 4 0 <1.00e-15 <1.00e-15 <3.08e-14 5 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(5), ACO2(4), FH(1), IDH1(398), IDH2(20) 6791681 428 419 15 0 381 14 4 28 1 0 <1.00e-15 <1.00e-15 <3.08e-14 6 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 80 AIFM1(4), AKT1(1), APAF1(3), ATM(8), BAX(1), BIRC2(2), CASP8(2), CFLAR(1), CSF2RB(2), CYCS(2), DFFA(2), FAS(1), FASLG(1), IKBKB(1), IL1B(2), IL1R1(2), IL1RAP(1), IL3(1), IL3RA(2), IRAK1(1), IRAK2(2), IRAK3(6), IRAK4(2), NFKB1(1), NFKB2(1), NFKBIA(2), NTRK1(2), PIK3CA(50), PIK3CB(3), PIK3CD(3), PIK3CG(5), PIK3R1(23), PIK3R2(1), PIK3R3(1), PIK3R5(1), PPP3CA(1), PPP3CC(1), PRKACG(1), PRKAR1A(2), RELA(1), RIPK1(3), TNF(1), TNFRSF10C(1), TNFRSF10D(1), TP53(312), TRADD(1), TRAF2(2) 63687268 470 314 272 36 128 59 77 98 100 8 <1.00e-15 <1.00e-15 <3.08e-14 7 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 15 AKT1(1), EGFR(45), IGF1R(7), POLR2A(7), PPP2CA(4), PRKCA(5), RB1(6), TEP1(8), TERF1(1), TERT(2), TNKS(1), TP53(312), XRCC5(3) 21504324 402 294 214 10 129 47 57 93 68 8 <1.00e-15 <1.00e-15 <3.08e-14 8 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 64 APAF1(3), ATM(8), ATR(6), BAI1(4), BAX(1), CASP8(2), CCNB1(2), CCNB2(1), CCNB3(4), CCND1(4), CCNE1(1), CCNE2(1), CCNG2(2), CDK2(1), CDK4(1), CDKN1A(1), CDKN2A(4), CHEK1(3), CHEK2(3), CYCS(2), DDB2(2), EI24(4), FAS(1), GTSE1(4), IGF1(1), MDM2(3), MDM4(1), PPM1D(3), PTEN(25), RCHY1(1), RFWD2(4), RRM2B(1), SERPINB5(1), SERPINE1(2), SESN1(1), SESN2(1), SESN3(1), SFN(2), SIAH1(3), STEAP3(2), THBS1(4), TP53(312), TP53I3(1), TSC2(3), ZMAT3(3) 49759824 440 293 266 29 128 48 71 98 88 7 <1.00e-15 <1.00e-15 <3.08e-14 9 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 16 APAF1(3), ATM(8), BAX(1), CCND1(4), CCNE1(1), CDK2(1), CDK4(1), CDKN1A(1), E2F1(1), MDM2(3), RB1(6), TIMP3(1), TP53(312) 13840624 343 263 172 7 112 33 53 72 66 7 <1.00e-15 <1.00e-15 <3.08e-14 10 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 41 APAF1(3), BAK1(2), BAX(1), BIRC2(2), CASP2(1), CASP8(2), CYCS(2), FAS(1), FASLG(1), GZMB(1), MAP3K1(3), MAPK10(1), MDM2(3), NFKB1(1), NFKBIA(2), PARP1(2), PRF1(3), RELA(1), RIPK1(3), TNF(1), TNFRSF1B(2), TP53(312), TRADD(1), TRAF2(2) 28486853 353 262 182 17 120 37 52 73 64 7 <1.00e-15 <1.00e-15 <3.08e-14 11 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 25 ABL1(4), ATM(8), ATR(6), CCNA1(2), CCND1(4), CCNE1(1), CDC25A(1), CDK2(1), CDK4(1), CDKN1A(1), CDKN1B(3), CDKN2A(4), DHFR(1), E2F1(1), RB1(6), SKP2(2), TGFB2(2), TGFB3(1), TP53(312) 23044919 361 262 190 9 117 35 55 73 74 7 <1.00e-15 <1.00e-15 <3.08e-14 12 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 22 ATM(8), ATR(6), BRCA1(2), CCNB1(2), CDC25A(1), CDC25B(1), CDC34(2), CDKN1A(1), CHEK1(3), CHEK2(3), EP300(5), MDM2(3), MYT1(7), PRKDC(11), RPS6KA1(4), TP53(312), WEE1(1), YWHAH(1), YWHAQ(1) 31816853 374 260 203 19 121 36 54 81 74 8 <1.00e-15 <1.00e-15 <3.08e-14 13 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 38 AKT1(1), ATF2(2), DLD(1), DUSP10(1), DUSP4(1), GCK(2), IL1R1(2), MAP2K5(2), MAP3K1(3), MAP3K10(1), MAP3K12(5), MAP3K13(2), MAP3K3(2), MAP3K4(4), MAP3K5(3), MAP3K9(3), MAPK10(1), MAPK7(5), MAPK8(2), MAPK9(1), MYEF2(3), NFATC3(2), NR2C2(2), PAPPA(4), SHC1(1), TP53(312), ZAK(2) 38409600 370 258 199 20 125 36 58 79 65 7 <1.00e-15 <1.00e-15 <3.08e-14 14 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 20 AKT1(1), APAF1(3), ATM(8), BAX(1), CYCS(2), PRKCA(5), PTK2(2), STAT1(2), TLN1(5), TP53(312) 20883638 341 257 170 9 113 32 51 74 62 9 <1.00e-15 <1.00e-15 <3.08e-14 15 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 18 DNAJA3(3), IFNGR2(1), IKBKB(1), JAK2(4), NFKB1(1), NFKBIA(2), RB1(6), RELA(1), TNF(1), TNFRSF1B(2), TP53(312), USH1C(1), WT1(1) 13823788 336 257 165 10 111 32 49 69 68 7 <1.00e-15 <1.00e-15 <3.08e-14 16 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 12 ATM(8), CDC25A(1), CDC25B(1), CDK2(1), CDK4(1), CHEK1(3), MYT1(7), RB1(6), TP53(312), WEE1(1), YWHAH(1) 13432550 342 255 171 8 111 32 51 67 74 7 <1.00e-15 <1.00e-15 <3.08e-14 17 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 9 DNAJC3(2), EIF2S2(1), NFKB1(1), NFKBIA(2), RELA(1), TP53(312) 7447224 319 249 148 6 108 32 47 66 59 7 <1.00e-15 <1.00e-15 <3.08e-14 18 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 AKT1(1), CCND1(4), CCNE1(1), CDK2(1), CDK4(1), CDKN1A(1), CDKN1B(3), E2F1(1), MAPK1(2), MAPK3(1), NFKB1(1), NFKBIA(2), PAK1(2), PIK3CA(50), PIK3R1(23), RAC1(1), RAF1(1), RB1(6), RELA(1) 15429192 103 78 76 8 8 16 25 12 40 2 9.39e-06 <1.00e-15 <3.08e-14 19 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 CSNK2A1(2), ELK1(3), FOS(1), MAPK3(1), MAPK8(2), NGFR(1), PIK3CA(50), PIK3R1(23), PLCG1(6), RAF1(1), SHC1(1), SOS1(4) 14582566 95 77 67 8 5 22 22 14 30 2 1.52e-05 <1.00e-15 <3.08e-14 20 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 ADRB2(1), AKT1(1), ANXA1(2), CALM3(1), GNAS(4), NFKB1(1), NOS3(7), NR3C1(3), PIK3CA(50), PIK3R1(23), RELA(1), SYT1(1) 13662769 95 76 68 10 12 18 23 13 28 1 0.000332 <1.00e-15 <3.08e-14 21 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 AKT1(1), EIF4A1(6), EIF4A2(2), EIF4B(2), EIF4E(2), EIF4G1(4), EIF4G2(1), EIF4G3(6), MKNK1(2), PIK3CA(50), PIK3R1(23), PPP2CA(4), PTEN(25), RPS6KB1(2), TSC1(2), TSC2(3) 21044906 135 106 106 11 13 27 30 25 39 1 3.03e-07 1.67e-15 4.56e-14 22 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 16 ABL1(4), CDKN2A(4), E2F1(1), MDM2(3), PIK3CA(50), PIK3R1(23), POLR1A(5), POLR1B(2), RAC1(1), RB1(6), TBX2(1), TP53(312) 15511338 412 303 214 12 114 47 70 78 95 8 <1.00e-15 1.78e-15 4.56e-14 23 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 AKT1(1), EIF2S2(1), EIF4E(2), IGF1(1), IGF1R(7), INPPL1(5), PIK3CA(50), PIK3R1(23), PPP2CA(4), PTEN(25), RPS6KB1(2) 14998106 121 97 92 5 8 22 29 23 38 1 2.22e-09 1.78e-15 4.56e-14 24 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 AKT1(1), NTRK1(2), PIK3CA(50), PIK3R1(23), PLCG1(6), PRKCA(5), SHC1(1), SOS1(4) 11877269 92 78 64 7 6 18 23 14 29 2 2.56e-05 1.78e-15 4.56e-14 25 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(5), ACO2(4), DLD(1), FH(1), IDH1(398), IDH2(20), IDH3B(1), PC(2), PCK1(3), SDHA(4), SUCLG2(1) 15706931 440 419 26 2 384 17 7 29 3 0 <1.00e-15 2.11e-15 5.00e-14 26 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 ADCY1(2), AKT1(1), BAX(1), CSF2RB(2), IGF1(1), IGF1R(7), IL3(1), IL3RA(2), KIT(6), KITLG(2), PIK3CA(50), PIK3R1(23), PRKACG(1), PRKAR1A(2), YWHAH(1) 16746155 102 80 75 8 9 16 27 17 32 1 4.75e-06 2.11e-15 5.00e-14 27 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 21 ATM(8), ATR(6), BRCA1(2), BRCA2(9), CHEK1(3), CHEK2(3), FANCA(4), FANCC(1), FANCD2(8), FANCE(2), HUS1(1), MRE11A(2), RAD1(2), RAD17(2), RAD50(5), RAD9A(2), TP53(312), TREX1(2) 33704497 374 264 202 13 120 45 58 77 67 7 <1.00e-15 2.33e-15 5.19e-14 28 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 7 MAX(4), SP3(4), TP53(312), WT1(1) 5382811 321 254 148 2 111 31 48 65 59 7 <1.00e-15 2.44e-15 5.19e-14 29 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 7 ATM(8), ATR(6), CHEK1(3), CHEK2(3), TP53(312), YWHAH(1) 12233125 333 249 162 7 111 34 50 68 63 7 <1.00e-15 2.44e-15 5.19e-14 30 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(2), EGF(7), EGFR(45), ELK1(3), FOS(1), JAK1(1), MAP3K1(3), MAPK3(1), MAPK8(2), PIK3CA(50), PIK3R1(23), PLCG1(6), PRKCA(5), RAF1(1), RASA1(4), SHC1(1), SOS1(4), SRF(2), STAT1(2), STAT3(2), STAT5A(1) 28629486 166 117 121 14 22 39 26 39 36 4 2.05e-09 2.55e-15 5.24e-14 31 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 59 BAK1(2), BAX(1), BFAR(1), BTK(2), CAD(5), CASP8(2), CD7(1), CSNK1A1(2), DAXX(2), DEDD2(1), DFFA(2), DIABLO(1), EGFR(45), EPHB2(2), FAF1(3), MAP3K1(3), MAP3K5(3), MAPK1(2), MAPK10(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(3), MAPK8IP3(3), MAPK9(1), MET(10), NFAT5(3), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIE(1), PTPN13(3), RALBP1(2), RIPK1(3), ROCK1(2), SMPD1(1), TNFRSF6B(1), TP53(312), TPX2(5), TRAF2(2) 55439306 440 290 252 22 138 58 61 97 79 7 <1.00e-15 2.78e-15 5.34e-14 32 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 AKT1(1), GH1(1), GHR(4), NFKB1(1), NFKBIA(2), PIK3CA(50), PIK3R1(23), PPP2CA(4), RELA(1), YWHAH(1) 10741939 88 70 61 6 5 18 21 15 28 1 1.82e-05 2.78e-15 5.34e-14 33 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 19 ABL1(4), ATM(8), BRCA1(2), CDKN1A(1), CHEK1(3), CHEK2(3), MAPK8(2), MDM2(3), MRE11A(2), NFKB1(1), NFKBIA(2), RAD50(5), RBBP8(2), RELA(1), TP53(312) 22752004 351 255 180 14 116 38 53 74 63 7 <1.00e-15 2.89e-15 5.39e-14 34 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 19 ABCB1(5), AKT1(1), ATM(8), BAX(1), CDKN1A(1), CPB2(1), CSNK1A1(2), CSNK1D(1), MAPK8(2), MDM2(3), NQO1(1), TP53(312) 15859090 338 255 167 11 112 32 50 74 63 7 <1.00e-15 3.00e-15 5.43e-14 35 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 66 APAF1(3), BAK1(2), BAX(1), BCL2L11(1), BIRC2(2), CASP1(4), CASP2(1), CASP4(1), CASP8(2), CYCS(2), DFFA(2), FAS(1), FASLG(1), GZMB(1), HELLS(3), IKBKB(1), IRF1(4), IRF2(1), IRF3(1), IRF4(2), IRF5(1), IRF6(2), IRF7(3), MAP3K1(3), MAPK10(1), MDM2(3), NFKB1(1), NFKBIA(2), NFKBIE(1), PLEKHG5(3), PRF1(3), RELA(1), RIPK1(3), TNF(1), TNFRSF1B(2), TNFRSF21(2), TNFRSF25(1), TP53(312), TRADD(1), TRAF2(2), TRAF3(1) 43592440 385 265 214 28 134 41 52 81 70 7 <1.00e-15 3.22e-15 5.67e-14 36 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 AKT1(1), IGF1R(7), IRS1(4), MAPK1(2), MAPK3(1), PIK3CA(50), PIK3R1(23), RAF1(1), SHC1(1), SOS1(4), YWHAH(1) 14488390 95 78 68 7 7 19 23 12 32 2 4.63e-06 3.33e-15 5.70e-14 37 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 144 APC(2), AXIN1(1), AXIN2(1), BTRC(1), CAMK2A(2), CAMK2D(1), CAMK2G(2), CCND1(4), CHD8(2), CREBBP(9), CSNK1A1(2), CSNK1A1L(2), CSNK1E(1), CSNK2A1(2), CSNK2B(1), CTBP1(5), CTBP2(1), CTNNB1(3), CUL1(1), CXXC4(1), DAAM1(1), DAAM2(2), DKK1(1), DKK2(2), DKK4(2), DVL2(1), DVL3(2), EP300(5), FZD1(2), FZD10(2), FZD4(1), FZD5(1), FZD6(2), FZD7(2), FZD8(2), FZD9(3), LEF1(1), LRP5(7), LRP6(7), MAPK10(1), MAPK8(2), MAPK9(1), NFAT5(3), NFATC1(2), NFATC2(5), NFATC3(2), NFATC4(3), NKD1(1), NKD2(4), NLK(1), PLCB1(3), PLCB2(4), PLCB3(4), PLCB4(3), PORCN(5), PPP2CA(4), PPP2CB(1), PPP2R1B(1), PPP2R2A(4), PPP2R2C(3), PPP3CA(1), PPP3CC(1), PRICKLE1(2), PRICKLE2(4), PRKACG(1), PRKCA(5), PRKCG(2), RAC1(1), RAC2(1), RBX1(1), ROCK1(2), ROCK2(4), RUVBL1(1), SENP2(3), SFRP1(1), SFRP2(2), SFRP4(1), SIAH1(3), SMAD2(3), SMAD3(3), SOX17(3), TBL1XR1(3), TBL1Y(1), TCF7L2(4), TP53(312), VANGL1(1), VANGL2(2), WIF1(2), WNT11(4), WNT16(2), WNT2(3), WNT2B(1), WNT3A(1), WNT5B(1), WNT7A(2), WNT8A(1), WNT8B(1), WNT9A(1), WNT9B(1) 123390588 535 301 363 73 178 60 74 118 97 8 <1.00e-15 3.55e-15 5.79e-14 38 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 109 ABL1(4), ANAPC1(2), ANAPC10(1), ANAPC2(2), ANAPC5(4), ANAPC7(1), ATM(8), ATR(6), BUB1(4), BUB1B(2), BUB3(3), CCNA1(2), CCNB1(2), CCNB2(1), CCNB3(4), CCND1(4), CCNE1(1), CCNE2(1), CCNH(2), CDC14A(2), CDC14B(5), CDC16(2), CDC20(1), CDC23(2), CDC25A(1), CDC25B(1), CDC27(4), CDC6(1), CDC7(2), CDK2(1), CDK4(1), CDKN1A(1), CDKN1B(3), CDKN2A(4), CDKN2C(3), CHEK1(3), CHEK2(3), CREBBP(9), CUL1(1), DBF4(5), E2F1(1), E2F2(1), E2F3(1), EP300(5), ESPL1(5), FZR1(3), HDAC2(4), MCM3(1), MCM4(3), MCM5(1), MCM6(3), MCM7(4), MDM2(3), PKMYT1(1), PLK1(2), PRKDC(11), RB1(6), RBL1(4), RBL2(3), RBX1(1), SFN(2), SKP2(2), SMAD2(3), SMAD3(3), SMC1A(5), SMC1B(7), TGFB2(2), TGFB3(1), TP53(312), WEE1(1), YWHAB(2), YWHAE(1), YWHAG(1), YWHAH(1), YWHAQ(1), YWHAZ(1) 103471764 517 293 346 57 142 64 83 118 100 10 <1.00e-15 3.66e-15 5.79e-14 39 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 CSNK2A1(2), ELK1(3), FOS(1), INSR(4), IRS1(4), MAPK3(1), MAPK8(2), PIK3CA(50), PIK3R1(23), PTPN11(7), RAF1(1), RASA1(4), SHC1(1), SLC2A4(1), SOS1(4), SRF(2) 19466630 110 85 81 12 11 25 22 19 31 2 3.39e-05 3.66e-15 5.79e-14 40 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 15 ARF1(1), CCND1(4), CDK2(1), CDK4(1), CDKN1A(1), CDKN1B(3), CDKN2A(4), CFL1(1), E2F1(1), E2F2(1), MDM2(3), PRB1(1), TP53(312) 6401614 334 255 163 5 112 31 51 67 66 7 <1.00e-15 3.77e-15 5.81e-14 41 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 13 CREBBP(9), DAXX(2), PAX3(1), PML(3), RB1(6), SIRT1(1), SP100(4), TNF(1), TNFRSF1B(2), TP53(312) 14514662 341 261 170 7 113 33 50 71 67 7 <1.00e-15 3.89e-15 5.84e-14 42 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ACTR2(2), ACTR3(1), ARPC1A(1), ARPC1B(2), ARPC3(1), PAK1(2), PDGFRA(18), PIK3CA(50), PIK3R1(23), RAC1(1), WASL(2) 10240289 103 76 74 9 2 24 22 21 33 1 6.05e-05 4.11e-15 6.02e-14 43 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 82 ABL1(4), ATM(8), BUB1(4), BUB1B(2), BUB3(3), CCNA1(2), CCNB1(2), CCNB2(1), CCNB3(4), CCNE1(1), CCNE2(1), CCNH(2), CDAN1(3), CDC14A(2), CDC14B(5), CDC20(1), CDC25A(1), CDC25B(1), CDC6(1), CDC7(2), CDH1(4), CDK2(1), CDK4(1), CDKN1A(1), CDKN2A(4), CHEK1(3), CHEK2(3), DTX4(2), E2F1(1), E2F2(1), E2F3(1), E2F5(1), EP300(5), ESPL1(5), HDAC2(4), HDAC3(1), HDAC4(3), HDAC5(1), HDAC6(3), MCM3(1), MCM4(3), MCM5(1), MCM6(3), MCM7(4), MDM2(3), MPEG1(2), MPL(2), PLK1(2), PRKDC(11), PTPRA(4), RB1(6), RBL1(4), SKP2(2), TBC1D8(1), TP53(312), WEE1(1) 83564504 457 277 286 50 134 56 67 102 88 10 <1.00e-15 4.22e-15 6.04e-14 44 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 AKT1(1), BCAR1(3), CDKN1B(3), ILK(1), ITGB1(2), MAPK1(2), MAPK3(1), PIK3CA(50), PIK3R1(23), PTEN(25), PTK2(2), SHC1(1), SOS1(4) 14720027 118 96 89 5 8 20 27 19 42 2 1.40e-08 4.33e-15 6.06e-14 45 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 13 AKT1(1), CAT(3), GH1(1), GHR(4), IGF1(1), IGF1R(7), PIK3CA(50), PIK3R1(23), SHC1(1), SOD2(1) 10169188 92 76 65 3 6 18 24 14 29 1 2.98e-08 4.55e-15 6.23e-14 46 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 CSNK2A1(2), ELK1(3), FOS(1), IGF1(1), IGF1R(7), IRS1(4), MAPK3(1), MAPK8(2), PIK3CA(50), PIK3R1(23), PTPN11(7), RAF1(1), RASA1(4), SHC1(1), SOS1(4), SRF(2) 18943384 113 91 84 11 10 24 25 19 33 2 6.47e-06 4.66e-15 6.24e-14 47 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 22 AKT1(1), EIF4A1(6), EIF4A2(2), EIF4E(2), EIF4G1(4), EIF4G2(1), EIF4G3(6), GHR(4), IRS1(4), MAPK1(2), MAPK3(1), MKNK1(2), PABPC1(4), PIK3CA(50), PIK3R1(23), PRKCA(5), PTEN(25), RPS6KB1(2) 21466241 144 110 115 16 16 28 31 24 42 3 8.42e-06 4.88e-15 6.40e-14 48 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 64 ATM(8), CCNA1(2), CCNB1(2), CCND1(4), CCNE1(1), CCNE2(1), CCNG2(2), CCNH(2), CDC25A(1), CDK2(1), CDK4(1), CDKN1A(1), CDKN1B(3), CDKN2A(4), CDKN2C(3), CREB3L1(1), E2F1(1), E2F2(1), E2F3(1), E2F5(1), GBA2(1), MCM3(1), MCM4(3), MCM5(1), MCM6(3), MCM7(4), MDM2(3), MYT1(7), NACA(5), POLA2(1), POLE(8), PRIM1(1), RB1(6), RBL1(4), RPA1(3), TNXB(11), TP53(312), WEE1(1) 58855578 416 276 245 35 126 39 62 88 94 7 <1.00e-15 5.22e-15 6.70e-14 49 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 AKT1(1), CREB1(1), MAPK1(2), MAPK3(1), MAPK7(5), MEF2A(2), MEF2B(1), NTRK1(2), PIK3CA(50), PIK3R1(23), PLCG1(6), RPS6KA1(4), SHC1(1) 14437791 99 80 71 11 5 20 23 16 33 2 0.000259 5.44e-15 6.70e-14 50 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD28(1), CD3D(1), CD86(1), CTLA4(1), HLA-DRA(3), HLA-DRB1(1), ICOS(1), ITK(1), LCK(1), PIK3CA(50), PIK3R1(23), PTPN11(7) 9780497 91 75 62 7 4 19 22 17 28 1 3.62e-05 5.44e-15 6.70e-14 51 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 35 CRKL(1), DOCK1(1), ELK1(3), FOS(1), HGF(3), ITGA1(2), ITGB1(2), MAP2K2(1), MAP4K1(1), MAPK1(2), MAPK3(1), MAPK8(2), MET(10), PAK1(2), PIK3CA(50), PIK3R1(23), PTEN(25), PTK2(2), PTK2B(2), PTPN11(7), RAF1(1), RASA1(4), SOS1(4), STAT3(2) 33579590 152 110 121 19 15 26 31 31 47 2 1.03e-05 5.77e-15 6.97e-14 52 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 CSNK2A1(2), FOS(1), JAK2(4), MAPK3(1), MPL(2), PIK3CA(50), PIK3R1(23), PLCG1(6), PRKCA(5), RAF1(1), RASA1(4), SHC1(1), SOS1(4), STAT1(2), STAT3(2), STAT5A(1), STAT5B(2), THPO(1) 22885449 112 85 84 11 11 21 24 20 32 4 1.97e-05 5.88e-15 6.97e-14 53 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 ARFIP2(2), CFL1(1), LIMK1(4), MAP3K1(3), MYL2(2), MYLK(5), NCF2(3), PAK1(2), PDGFRA(18), PIK3CA(50), PIK3R1(23), PLD1(7), RAC1(1), RALBP1(2), RPS6KB1(2), TRIO(5), VAV1(5), WASF1(1) 26630188 136 94 107 12 16 26 30 24 39 1 1.97e-07 6.66e-15 7.59e-14 54 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 AKT1(1), CREB1(1), MAP2K2(1), MAP2K3(3), MAP3K1(3), MAPK1(2), MAPK3(1), NFKB1(1), PIK3CA(50), PIK3R1(23), RB1(6), RELA(1) 14830803 93 73 66 10 8 17 23 10 33 2 0.000438 6.66e-15 7.59e-14 55 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 AKT1(1), PIK3CA(50), PIK3R1(23), PLCB1(3), PLCG1(6), PRKCA(5), VAV1(5) 9804294 93 77 65 8 7 18 22 17 27 2 6.87e-05 6.77e-15 7.59e-14 56 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 HLA-A(1), IL18(3), ITGB1(2), KLRC1(2), KLRC2(1), KLRC4(1), LAT(2), MAPK3(1), PAK1(2), PIK3CA(50), PIK3R1(23), PTK2B(2), RAC1(1), VAV1(5) 14225470 96 74 69 9 7 18 23 14 32 2 4.65e-05 7.66e-15 8.43e-14 57 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 AKT1(1), CHRNB1(2), CHRNG(2), MUSK(4), PIK3CA(50), PIK3R1(23), PTK2(2), PTK2B(2), RAPSN(1), TERT(2), YWHAH(1) 12450892 90 74 63 10 7 16 22 15 29 1 0.000487 7.99e-15 8.61e-14 58 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 AKT1(1), BPNT1(1), ILK(1), MAPK1(2), MAPK3(1), PDK1(2), PIK3CA(50), PIK3CD(3), PTEN(25), PTK2B(2), RBL2(3), SHC1(1), SOS1(4) 15556776 96 76 73 9 6 21 21 25 22 1 9.25e-06 8.10e-15 8.61e-14 59 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 AKT1(1), APC(2), AR(4), ASAH1(1), BRAF(6), CCL16(1), DAG1(1), EGFR(45), GNA11(1), GNA15(1), GNAI1(4), ITPR1(4), ITPR2(12), ITPR3(13), KCNJ3(1), KCNJ5(3), KCNJ9(1), MAPK1(2), MAPK10(1), PHKA2(5), PIK3CA(50), PIK3CD(3), PIK3R1(23), PITX2(4), PTX3(2), RAF1(1) 40782051 192 128 147 25 25 37 44 47 36 3 2.62e-07 9.77e-15 1.02e-13 60 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(7), EGFR(45), ERBB3(4), NRG1(3) 7872833 59 43 42 3 13 17 2 20 7 0 1.06e-05 1.30e-14 1.33e-13 61 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 AKT1(1), ELK1(3), H2AFX(1), MAPK3(1), NFKB1(1), PIK3CA(50), PIK3R1(23), RAC1(1), RAF1(1), RALA(2), RALBP1(2), RALGDS(2), RELA(1) 14539343 89 66 62 10 5 16 21 13 32 2 0.000539 2.08e-14 2.10e-13 62 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 AKT1(1), BCR(3), CRKL(1), FOS(1), JAK2(4), MAP3K1(3), MAPK3(1), MAPK8(2), PIK3CA(50), PIK3R1(23), RAF1(1), SOS1(4), STAT1(2), STAT5A(1), STAT5B(2) 21457321 99 74 72 10 8 21 23 15 29 3 3.18e-05 4.26e-14 4.24e-13 63 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT1(1), CDKN1A(1), ELK1(3), MAP2K2(1), NGFR(1), NTRK1(2), PIK3CA(50), PIK3CD(3), SHC1(1), SOS1(4) 12312407 67 52 46 5 7 15 17 14 14 0 2.08e-05 9.81e-14 9.60e-13 64 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 28 BRAF(6), CPEB1(3), EGFR(45), ERBB2(2), ERBB4(5), ETS1(3), ETV6(4), ETV7(1), FMN2(3), KRAS(3), MAPK1(2), MAPK3(1), NOTCH1(52), NOTCH2(11), NOTCH3(6), NOTCH4(8), PIWIL2(3), PIWIL3(3), PIWIL4(1), RAF1(1), SOS1(4), SOS2(5), SPIRE1(1), SPIRE2(2) 39905040 175 113 145 22 30 36 15 50 39 5 2.88e-06 2.16e-13 2.08e-12 65 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 ADCY1(2), AKT1(1), CAMK2A(2), CAMK2D(1), CAMK2G(2), CREB1(1), GNAS(4), MAPK1(2), MAPK3(1), PIK3CA(50), PIK3R1(23), PRKACG(1), PRKAR1A(2), PRKCA(5), RAC1(1), RPS6KA1(4), RPS6KA5(1), SOS1(4) 22233763 107 82 80 12 14 17 24 15 34 3 0.000176 3.33e-13 3.16e-12 66 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(3), EGF(7), EGFR(45), HGS(3), TF(2), TFRC(2) 9806502 62 45 45 6 12 18 4 23 5 0 0.000189 5.25e-13 4.90e-12 67 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 33 A1BG(1), AKT1(1), BTK(2), CDKN2A(4), IARS(1), INPP5D(2), PDK1(2), PIK3CA(50), PPP1R13B(1), PTEN(25), RPS6KA1(4), RPS6KA2(3), RPS6KA3(3), RPS6KB1(2), SFN(2), SHC1(1), SOS1(4), SOS2(5), TEC(3), YWHAB(2), YWHAE(1), YWHAG(1), YWHAH(1), YWHAQ(1), YWHAZ(1) 27422364 123 89 100 14 9 22 30 33 29 0 1.02e-05 1.06e-12 9.78e-12 68 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 FURIN(1), NOTCH1(52) 7076426 53 42 41 4 5 8 2 11 24 3 0.00943 1.12e-12 1.01e-11 69 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 25 GH1(1), GHR(4), INSR(4), IRS1(4), JAK2(4), MAPK1(2), MAPK3(1), PIK3CA(50), PIK3R1(23), PLCG1(6), PRKCA(5), RAF1(1), RPS6KA1(4), SHC1(1), SLC2A4(1), SOS1(4), SRF(2), STAT5A(1), STAT5B(2) 25258014 120 90 92 16 11 25 26 22 33 3 0.000155 1.56e-12 1.39e-11 70 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 49 AKT1(1), BRD4(1), CBL(1), CDKN2A(4), FLOT2(3), INPPL1(5), IRS1(4), IRS2(1), IRS4(5), LNPEP(1), MAPK1(2), MAPK3(1), PARD3(2), PARD6A(1), PDK1(2), PIK3CA(50), PIK3CD(3), PIK3R1(23), PTEN(25), PTPN1(1), RAF1(1), RPS6KA1(4), RPS6KA2(3), RPS6KA3(3), RPS6KB1(2), SFN(2), SHC1(1), SLC2A4(1), SORBS1(1), SOS1(4), SOS2(5), YWHAB(2), YWHAE(1), YWHAG(1), YWHAH(1), YWHAQ(1), YWHAZ(1) 45393970 170 115 141 19 16 28 36 39 49 2 5.90e-07 1.62e-12 1.43e-11 71 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(2), ELK1(3), FOS(1), JAK1(1), MAP3K1(3), MAPK3(1), MAPK8(2), PDGFA(1), PDGFRA(18), PIK3CA(50), PIK3R1(23), PLCG1(6), PRKCA(5), RAF1(1), RASA1(4), SHC1(1), SOS1(4), SRF(2), STAT1(2), STAT3(2), STAT5A(1) 26670905 133 94 103 17 13 30 26 24 36 4 4.74e-05 4.41e-12 3.83e-11 72 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(1), CSF1R(4), EGF(7), EGFR(45), MET(10), PDGFRA(18), PRKCA(5), SH3GLB1(3), SH3KBP1(5) 14808804 98 60 79 13 19 25 8 33 12 1 5.93e-05 9.06e-12 7.75e-11 73 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 AKT1(1), APC(2), AXIN1(1), CCND1(4), CD14(1), CTNNB1(3), FZD1(2), GJA1(5), GNAI1(4), IRAK1(1), LBP(2), LEF1(1), NFKB1(1), PIK3CA(50), PIK3R1(23), PPP2CA(4), RELA(1), TLR4(2), TOLLIP(1) 23445146 109 84 82 14 13 20 27 17 31 1 0.000198 1.25e-11 1.06e-10 74 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 ADCY1(2), AKT1(1), ASAH1(1), GNAI1(4), ITGAV(2), ITGB3(2), MAPK1(2), MAPK3(1), PDGFA(1), PDGFRA(18), PIK3CA(50), PIK3R1(23), PLCB1(3), PRKCA(5), PTK2(2), RAC1(1), SMPD1(1), SMPD2(1) 20944922 120 83 91 17 8 23 30 20 36 3 0.000336 2.44e-11 2.03e-10 75 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 CREBBP(9), EP300(5), FYN(1), IL7R(1), JAK1(1), JAK3(3), LCK(1), PIK3CA(50), PIK3R1(23), PTK2B(2), STAT5A(1), STAT5B(2) 21364089 99 77 72 13 8 18 23 19 30 1 0.00134 3.47e-11 2.85e-10 76 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 42 CALM3(1), CD3D(1), ELK1(3), FOS(1), FYN(1), LAT(2), LCK(1), MAP3K1(3), MAPK3(1), MAPK8(2), NFATC1(2), NFATC2(5), NFATC3(2), NFATC4(3), NFKB1(1), NFKBIA(2), PIK3CA(50), PIK3R1(23), PLCG1(6), PPP3CA(1), PPP3CC(1), PRKCA(5), PTPN7(2), RAC1(1), RAF1(1), RASA1(4), RELA(1), SHC1(1), SOS1(4), SYT1(1), VAV1(5), ZAP70(5) 36517448 142 96 114 17 22 27 26 27 37 3 2.51e-06 6.85e-11 5.55e-10 77 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 AKT1(1), CABIN1(6), CALM3(1), CAMK1(1), CAMK1G(1), HDAC5(1), IGF1(1), IGF1R(7), INSR(4), MAPK7(5), MEF2A(2), MEF2B(1), NFATC1(2), NFATC2(5), PIK3CA(50), PIK3R1(23), PPP3CA(1), PPP3CC(1), SYT1(1), YWHAH(1) 26541448 115 84 88 16 15 22 26 18 33 1 0.000190 8.44e-11 6.75e-10 78 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 BTK(2), CALM3(1), ELK1(3), FCER1A(2), FOS(1), MAP3K1(3), MAPK1(2), MAPK3(1), MAPK8(2), NFATC1(2), NFATC2(5), NFATC3(2), NFATC4(3), PAK2(2), PIK3CA(50), PIK3R1(23), PLA2G4A(4), PLCG1(6), PPP3CA(1), PPP3CC(1), RAF1(1), SHC1(1), SOS1(4), SYT1(1), VAV1(5) 32874618 128 90 100 15 14 25 28 26 33 2 1.14e-05 4.19e-10 3.31e-09 79 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 32 DUSP1(1), MAPK1(2), MAPK10(1), MAPK12(2), MAPK13(1), MAPK3(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(3), MAPK8IP3(3), MAPK9(1), MAPKAPK5(2), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIE(1), PIK3CA(50), PIK3CD(3), PIK3R1(23), SYT1(1), TRAF2(2), TRAF3(1), TRAF5(3) 25634364 108 79 81 13 14 20 25 16 31 2 5.10e-05 1.33e-09 1.03e-08 80 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(2), DIAPH1(5), FYN(1), GSN(1), ITGA1(2), ITGB1(2), MAPK1(2), MAPK3(1), MYL2(2), MYLK(5), PIK3CA(50), PIK3R1(23), PTK2(2), RAF1(1), ROCK1(2), SHC1(1), TLN1(5) 28487252 107 80 80 13 12 16 28 18 31 2 0.000153 6.73e-09 5.18e-08 81 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 42 AKT1(1), ASAH1(1), ATF1(1), BRAF(6), CREB1(1), CREBBP(9), CRKL(1), DAG1(1), EGR1(2), EGR3(1), ELK1(3), FRS2(1), MAP1B(8), MAPK1(2), MAPK10(1), MAPK3(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(3), MAPK8IP3(3), MAPK9(1), NTRK1(2), OPN1LW(1), PIK3C2G(1), PIK3CA(50), PIK3CD(3), PIK3R1(23), PTPN11(7), RPS6KA3(3), SHC1(1), TERF2IP(1), TH(3) 39218137 145 98 115 20 16 25 32 32 38 2 3.73e-05 9.54e-09 7.25e-08 82 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 51 AGT(2), AKT1(1), CALM3(1), CALR(2), CAMK1(1), CAMK1G(1), CAMK4(2), CREBBP(9), CSNK1A1(2), F2(3), GATA4(1), IGF1(1), MAPK1(2), MAPK3(1), MAPK8(2), MYH2(16), NFATC1(2), NFATC2(5), NFATC3(2), NFATC4(3), PIK3CA(50), PIK3R1(23), PPP3CA(1), PPP3CC(1), PRKACG(1), PRKAR1A(2), RAF1(1), RPS6KB1(2), SYT1(1) 38788188 141 94 113 17 25 22 30 27 35 2 2.52e-06 1.67e-08 1.26e-07 83 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 33 AKT1(1), BCR(3), BTK(2), CD19(1), CDKN2A(4), FLOT2(3), ITPR1(4), ITPR2(12), ITPR3(13), PDK1(2), PHF11(1), PIK3CA(50), PITX2(4), PLCG2(9), PPP1R13B(1), PREX1(5), PTEN(25), PTPRC(7), RPS6KA1(4), RPS6KA2(3), RPS6KA3(3), RPS6KB1(2), SAG(2), TEC(3), VAV1(5) 42076749 169 109 146 27 31 29 34 44 30 1 1.04e-05 4.99e-08 3.71e-07 84 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 63 AKT1(1), CDK2(1), CDKN1B(3), CDKN2A(4), CREB1(1), ERBB4(5), IGF1(1), INPPL1(5), IRS1(4), IRS2(1), IRS4(5), MET(10), PAK1(2), PAK2(2), PAK3(3), PAK4(1), PAK6(3), PAK7(4), PARD3(2), PARD6A(1), PDK1(2), PIK3CA(50), PIK3CD(3), PPP1R13B(1), PREX1(5), PTEN(25), PTK2(2), PTPN1(1), RPS6KA1(4), RPS6KA2(3), RPS6KA3(3), RPS6KB1(2), SFN(2), SHC1(1), SLC2A4(1), SOS1(4), SOS2(5), TSC1(2), TSC2(3), YWHAB(2), YWHAE(1), YWHAG(1), YWHAH(1), YWHAQ(1), YWHAZ(1) 58889933 185 118 162 25 24 32 40 49 40 0 3.97e-07 7.23e-08 5.25e-07 85 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT1(1), CISH(1), IARS(1), IL13RA1(3), IL4R(2), INPP5D(2), JAK1(1), JAK2(4), JAK3(3), PI3(2), PIK3CA(50), PPP1R13B(1), RPS6KB1(2), SERPINA4(2), SHC1(1), SOS1(4), SOS2(5), STAT6(4), TYK2(7) 28158111 96 68 75 7 13 16 23 24 20 0 6.69e-07 7.25e-08 5.25e-07 86 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 44 AKT1(1), BRAF(6), CAB39(2), EIF4B(2), IGF1(1), MAPK1(2), MAPK3(1), PGF(1), PIK3CA(50), PIK3CB(3), PIK3CD(3), PIK3CG(5), PIK3R1(23), PIK3R2(1), PIK3R3(1), PIK3R5(1), PRKAA1(3), PRKAA2(2), RPS6KA1(4), RPS6KA2(3), RPS6KA3(3), RPS6KA6(3), RPS6KB1(2), RPS6KB2(3), STK11(1), TSC1(2), TSC2(3), ULK1(1), ULK2(5), VEGFA(2), VEGFB(2), VEGFC(2) 40539457 144 94 115 18 20 22 33 30 37 2 1.72e-05 1.03e-07 7.39e-07 87 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(7), EGFR(45), MAP3K1(3), NCOR2(7), RXRA(1), THRA(2), THRB(2) 13153693 67 51 49 9 15 19 3 22 8 0 0.000487 1.83e-07 1.29e-06 88 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 27 AKT1(1), IL4R(2), IRS1(4), IRS2(1), JAK1(1), JAK3(3), MAP4K1(1), MAPK1(2), MAPK3(1), PDK1(2), PIK3CA(50), PIK3CD(3), PIK3R1(23), PPP1R13B(1), RAF1(1), SHC1(1), SOS1(4), SOS2(5), STAT6(4) 27815109 110 81 83 15 9 20 23 23 33 2 0.000664 6.50e-07 4.55e-06 89 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(1), EGF(7), EGFR(45), MAPK1(2), MAPK3(1), PTPRB(6), RAF1(1), RASA1(4), SHC1(1), SOS1(4), SPRY1(1), SPRY2(3), SPRY3(1), SPRY4(3) 19031632 80 54 63 9 17 17 6 25 14 1 0.000152 3.44e-06 2.38e-05 90 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 APC(2), AXIN1(1), BTRC(1), CTNNB1(3), FZD1(2), NOTCH1(52) 16327101 61 47 49 8 6 9 3 13 27 3 0.0873 1.27e-05 8.71e-05 91 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 34 AKT1(1), CBL(1), CFLAR(1), CRKL(1), E2F1(1), FOS(1), IL2RB(2), IRS1(4), JAK1(1), JAK3(3), MAPK1(2), MAPK3(1), PIK3CA(50), PIK3R1(23), RAF1(1), RPS6KB1(2), SHC1(1), SOS1(4), STAT5A(1), STAT5B(2) 27596363 103 80 76 16 7 22 23 16 33 2 0.00212 1.37e-05 9.30e-05 92 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 BCAR1(3), CXCR4(2), GNAI1(4), MAPK1(2), MAPK3(1), NFKB1(1), PIK3C2G(1), PIK3CA(50), PIK3R1(23), PLCG1(6), PRKCA(5), PTK2(2), PTK2B(2), RAF1(1), RELA(1) 21075384 104 85 76 20 9 18 27 15 32 3 0.0188 7.63e-05 0.000511 93 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 44 ACTR2(2), ACTR3(1), AKT1(1), ANGPTL2(2), ARHGAP1(1), ARHGAP4(2), ARHGEF11(2), BTK(2), CFL1(1), CFL2(1), GDI1(3), GDI2(1), INPPL1(5), ITPR1(4), ITPR2(12), ITPR3(13), LIMK1(4), MYLK(5), MYLK2(1), PAK1(2), PAK2(2), PAK3(3), PAK4(1), PAK6(3), PAK7(4), PDK1(2), PIK3CA(50), PIK3CD(3), PIK3CG(5), PIK3R1(23), PITX2(4), PPP1R13B(1), PTEN(25), ROCK1(2), ROCK2(4), RPS4X(2), SAG(2), WASF1(1), WASL(2) 53475792 204 129 175 31 30 39 44 45 44 2 3.36e-06 8.02e-05 0.000531 94 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(4), FH(1), IDH2(20), OGDH(1), SDHA(4) 7172508 30 28 12 5 4 12 6 7 1 0 0.0218 9.66e-05 0.000633 95 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 85 ABL1(4), ABL2(1), AKT1(1), ARAF(1), AREG(2), BRAF(6), BTC(1), CAMK2A(2), CAMK2D(1), CAMK2G(2), CBL(1), CBLB(2), CBLC(2), CDKN1A(1), CDKN1B(3), CRKL(1), EGF(7), EGFR(45), ELK1(3), ERBB2(2), ERBB3(4), ERBB4(5), EREG(1), HBEGF(1), KRAS(3), MAP2K2(1), MAPK1(2), MAPK10(1), MAPK3(1), MAPK8(2), MAPK9(1), NCK1(2), NRAS(4), NRG1(3), NRG2(1), PAK1(2), PAK2(2), PAK3(3), PAK4(1), PAK6(3), PAK7(4), PIK3CA(50), PIK3CB(3), PIK3CD(3), PIK3CG(5), PIK3R1(23), PIK3R2(1), PIK3R3(1), PIK3R5(1), PLCG1(6), PLCG2(9), PRKCA(5), PRKCG(2), PTK2(2), RAF1(1), RPS6KB1(2), RPS6KB2(3), SHC1(1), SHC2(1), SHC3(1), SHC4(1), SOS1(4), SOS2(5), STAT5A(1), STAT5B(2) 78517936 268 161 221 38 47 50 43 64 61 3 7.36e-09 0.000139 0.000902 96 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(2), ARHGEF1(1), F2(3), F2R(2), F2RL3(1), GNA13(1), GNAI1(4), PIK3CA(50), PIK3R1(23), PLCB1(3), PRKCA(5), PTK2B(2), ROCK1(2) 19725086 99 76 72 18 8 18 25 17 29 2 0.0121 0.000183 0.00118 97 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 AGT(2), AGTR2(3), EDNRA(1), EDNRB(1), EGF(7), EGFR(45), FOS(1), NFKB1(1), PLCG1(6), PRKCA(5), RELA(1) 15656635 73 52 55 14 14 20 5 28 5 1 0.00685 0.00103 0.00656 98 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 ARNT(1), EIF2B4(1), EIF2S2(1), FLT1(5), FLT4(6), KDR(6), NOS3(7), PIK3CA(50), PIK3R1(23), PLCG1(6), PRKCA(5), PTK2(2), SHC1(1) 25920426 114 88 86 24 11 21 28 20 32 2 0.0328 0.00111 0.00698 99 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 AKT1(1), BCR(3), BLNK(2), BTK(2), CD19(1), CSK(1), DAG1(1), EPHB2(2), MAP2K2(1), MAPK1(2), NFAT5(3), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIE(1), PI3(2), PIK3CA(50), PIK3CD(3), PIK3R1(23), PLCG2(9), PPP1R13B(1), RAF1(1), SERPINA4(2), SHC1(1), SOS1(4), SOS2(5), VAV1(5) 40153640 130 91 103 22 25 22 25 24 33 1 0.000578 0.00162 0.0101 100 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(4), CYP2C9(3) 1546684 7 7 7 0 3 2 0 1 1 0 0.127 0.00262 0.0162 101 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGT(2), ATF2(2), CALM3(1), EGFR(45), ELK1(3), MAP2K2(1), MAP3K1(3), MAPK1(2), MAPK3(1), MAPK8(2), MEF2A(2), MEF2B(1), PAK1(2), PRKCA(5), PTK2(2), PTK2B(2), RAC1(1), RAF1(1), SHC1(1), SOS1(4), SYT1(1) 25563321 84 54 67 13 13 22 7 26 14 2 0.000611 0.00622 0.0380 102 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(2), CCND1(4), CCNE1(1), CCNE2(1), CDK2(1), CDK4(1), CDKN1B(3), CDKN2A(4), E2F1(1), E2F2(1), PRB1(1) 6796377 20 16 20 0 4 1 5 2 8 0 0.00260 0.00789 0.0476 103 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 EGFR(45), ELK1(3), GNAS(4), IGF1R(7), ITGB1(2), MAP2K2(1), MAPK1(2), MAPK3(1), MKNK1(2), NGFR(1), PDGFRA(18), PPP2CA(4), PTPRR(3), RAF1(1), RPS6KA1(4), RPS6KA5(1), SHC1(1), SOS1(4), STAT3(2) 25232574 106 65 87 18 19 26 10 34 16 1 0.000801 0.0152 0.0911 104 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(2), GSTZ1(3), HGD(5) 1697424 10 6 10 2 4 0 1 2 3 0 0.309 0.0283 0.168 105 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT1(1), ASAH1(1), BRAF(6), DAG1(1), EGFR(45), EPHB2(2), ITPR1(4), ITPR2(12), ITPR3(13), KCNJ3(1), KCNJ5(3), KCNJ9(1), MAPK1(2), PI3(2), PIK3CB(3), PITX2(4), PLCB1(3), PLCB2(4), PLCB3(4), PLCB4(3), RAF1(1), SHC1(1), SOS1(4), SOS2(5), STAT3(2), TERF2IP(1) 44620819 129 77 111 21 27 23 21 47 10 1 9.87e-05 0.0303 0.178 106 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP1(1), ACPP(4), ENPP1(4), ENPP3(2), FLAD1(2), TYR(4) 7393124 17 14 17 1 6 2 2 5 2 0 0.0379 0.0326 0.190 107 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CCNA1(2), CCNB1(2), CCND1(4), CCNE1(1), CCNH(2), CDC25A(1), CDK2(1), CDK4(1), CDKN1A(1), CDKN1B(3), CDKN2A(4), CDKN2C(3), E2F1(1), RB1(6), RBL1(4) 12244687 36 25 36 4 7 3 8 5 13 0 0.0196 0.0365 0.210 108 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 ACTR2(2), ACTR3(1), AKT1(1), ANGPTL2(2), DAG1(1), DGKA(3), ITPR1(4), ITPR2(12), ITPR3(13), MAPK1(2), MAPK3(1), PAK1(2), PDE3A(2), PI3(2), PIK3C2G(1), PIK3CA(50), PIK3CD(3), PIK3R1(23), PSME1(3), RPS4X(2), SGCB(1) 37125845 131 92 104 28 14 20 34 24 36 3 0.0228 0.0373 0.213 109 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CCNE1(1), CDC34(2), CDK2(1), CUL1(1), E2F1(1), FBXW7(4), RB1(6) 6310719 16 13 16 1 4 2 2 2 6 0 0.0855 0.0409 0.231 110 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(2), CCNE1(1), CDC34(2), CDK2(1), CUL1(1), E2F1(1), RB1(6), SKP2(2) 6521310 16 13 16 1 2 2 4 1 7 0 0.0980 0.0447 0.250 111 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 247 ACVR1B(3), ACVR1C(1), AKT1(1), ARRB1(2), ARRB2(1), ATF2(2), ATF4(1), BDNF(1), BRAF(6), CACNA1A(3), CACNA1B(9), CACNA1C(2), CACNA1D(7), CACNA1E(7), CACNA1F(6), CACNA1G(7), CACNA1H(7), CACNA1I(6), CACNA1S(7), CACNA2D1(6), CACNA2D2(1), CACNA2D3(2), CACNA2D4(2), CACNB2(3), CACNB3(2), CACNB4(2), CACNG1(2), CACNG2(1), CACNG3(6), CACNG7(3), CACNG8(1), CD14(1), CDC25B(1), CRKL(1), DAXX(2), DDIT3(1), DUSP1(1), DUSP10(1), DUSP14(1), DUSP16(3), DUSP4(1), DUSP5(3), DUSP7(1), DUSP9(2), EGF(7), EGFR(45), ELK1(3), ELK4(1), FAS(1), FASLG(1), FGF13(2), FGF14(1), FGF16(1), FGF4(1), FGF5(3), FGF6(1), FGF7(1), FGFR1(2), FGFR2(2), FGFR3(2), FGFR4(3), FLNA(13), FLNB(9), FLNC(12), FOS(1), GNG12(1), IKBKB(1), IL1B(2), IL1R1(2), IL1R2(3), KRAS(3), MAP2K2(1), MAP2K3(3), MAP2K5(2), MAP3K1(3), MAP3K10(1), MAP3K12(5), MAP3K13(2), MAP3K3(2), MAP3K4(4), MAP3K5(3), MAP3K6(1), MAP3K8(4), MAP4K1(1), MAP4K3(2), MAP4K4(2), MAPK1(2), MAPK10(1), MAPK12(2), MAPK13(1), MAPK3(1), MAPK7(5), MAPK8(2), MAPK8IP1(1), MAPK8IP2(3), MAPK8IP3(3), MAPK9(1), MAPKAPK2(1), MAPKAPK3(1), MAPKAPK5(2), MAX(4), MKNK1(2), MRAS(1), NF1(38), NFATC2(5), NFATC4(3), NFKB1(1), NFKB2(1), NLK(1), NR4A1(1), NRAS(4), NTF3(1), NTRK1(2), PAK1(2), PAK2(2), PDGFA(1), PDGFRA(18), PDGFRB(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(4), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PPM1A(1), PPM1B(2), PPP3CA(1), PPP3CC(1), PRKACG(1), PRKCA(5), PRKCG(2), PTPN5(1), PTPN7(2), PTPRR(3), RAC1(1), RAC2(1), RAF1(1), RAPGEF2(4), RASA1(4), RASA2(3), RASGRF1(4), RASGRF2(4), RASGRP1(1), RASGRP2(2), RASGRP3(2), RASGRP4(2), RPS6KA1(4), RPS6KA2(3), RPS6KA3(3), RPS6KA5(1), RPS6KA6(3), RRAS(1), SOS1(4), SOS2(5), SRF(2), STK3(2), STMN1(1), TAOK1(2), TAOK2(4), TGFB2(2), TGFB3(1), TGFBR1(2), TGFBR2(3), TNF(1), TP53(312), TRAF2(2), ZAK(2) 217849524 824 381 629 154 239 121 106 180 156 22 <1.00e-15 0.0480 0.266 112 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(1), ALPP(5), ALPPL2(2), DHFR(1), FPGS(2), GGH(1), SPR(1) 4957773 13 12 13 2 5 2 3 1 2 0 0.161 0.0636 0.350 113 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ2(1), COQ3(2), COQ5(3), COQ6(2), NDUFB11(1) 3060056 9 7 9 0 1 4 0 2 2 0 0.0791 0.0725 0.395 114 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP1(1), ACPP(4), ENPP1(4), ENPP3(2), FLAD1(2), MTMR1(4), MTMR2(3), MTMR6(1), TYR(4) 11461538 25 19 25 2 6 4 4 7 4 0 0.0235 0.0743 0.401 115 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(5), ENPP1(4), ENPP3(2), NADSYN1(4), NMNAT1(1), NNMT(1), NNT(5), NT5C(3), NT5E(1), NT5M(1) 11099026 27 18 27 2 4 9 4 7 3 0 0.00451 0.0836 0.446 116 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CCNE1(1), CDK2(1), CDKN1B(3), CUL1(1), E2F1(1), RB1(6), RBX1(1), SKP2(2), UBE2M(1) 6533825 17 14 17 2 1 3 4 1 8 0 0.188 0.0840 0.446 117 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYA(1), RB1(6), SP3(4) 5084809 11 9 11 1 1 0 2 1 7 0 0.413 0.109 0.576 118 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(2), CYP2A13(1), CYP2A7(1), NAT1(1), NAT2(3), XDH(8) 6079271 16 11 16 1 4 3 1 6 2 0 0.0312 0.145 0.760 119 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(4), IL12B(2), IL18(3) 2273114 9 5 9 2 2 1 1 5 0 0 0.469 0.148 0.764 120 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RANBP1(1), RANBP2(11) 6433347 12 10 12 1 2 2 3 4 1 0 0.0803 0.175 0.899 121 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(2), ACOX3(3), FADS2(2), PLA2G12B(1), PLA2G2D(1), PLA2G3(4), PLA2G4A(4), PLA2G5(1), PLA2G6(2) 7701930 20 11 20 3 4 3 4 6 3 0 0.123 0.202 1.000 122 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(1), ENO1(2), GPI(2), HK1(4), PFKL(4), PGK1(2), PKLR(3), TPI1(1) 7067262 19 12 19 0 7 7 0 1 4 0 0.000165 0.214 1.000 123 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCL11(2), CCR3(1), CD4(1), HLA-DRA(3), HLA-DRB1(1), IL1B(2), IL5(1), IL5RA(2), IL6(1) 4080134 14 9 14 2 2 4 0 7 1 0 0.115 0.218 1.000 124 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(5) 1614982 5 4 5 0 2 1 0 2 0 0 0.207 0.236 1.000 125 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3D(1), CD4(1), FYN(1), HLA-DRA(3), HLA-DRB1(1), LCK(1), PTPRC(7), ZAP70(5) 6907169 20 13 20 4 5 5 1 8 1 0 0.195 0.245 1.000 126 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(1), COASY(2), DPYD(4), DPYS(4), ENPP1(4), ENPP3(2), PANK2(1), PANK4(3) 10605104 21 16 20 4 4 5 0 7 5 0 0.303 0.254 1.000 127 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(5), AMY2B(3), ENPP1(4), ENPP3(2), G6PC(7), GAA(5), GANAB(4), GBE1(1), GCK(2), GPI(2), GUSB(3), GYS1(1), GYS2(2), HK1(4), HK2(3), HK3(3), MGAM(7), PGM3(1), PYGB(1), PYGL(5), PYGM(1), SI(9), UCHL3(1), UGDH(1), UGT1A1(5), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A5(2), UGT1A6(2), UGT1A7(2), UGT2B15(2), UGT2B4(4), UXS1(2) 43400818 101 62 100 15 35 18 13 23 12 0 5.24e-05 0.256 1.000 128 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(1), COASY(2), DPYD(4), DPYS(4), ENPP1(4), ENPP3(2), ILVBL(5), PANK2(1), PANK4(3), VNN1(2) 13159542 28 21 27 4 6 6 1 9 6 0 0.0909 0.266 1.000 129 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDFT1(1), FDPS(1), IDI1(2), SQLE(1) 2417614 5 4 5 0 0 0 3 0 2 0 0.337 0.282 1.000 130 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(5), ENPP1(4), ENPP3(2), NADK(1), NADSYN1(4), NMNAT1(1), NMNAT3(1), NNMT(1), NNT(5), NT5C(3), NT5C1A(1), NT5C1B(5), NT5C2(1), NT5E(1), NT5M(1) 16405697 36 22 36 6 7 11 5 8 5 0 0.0262 0.283 1.000 131 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDFT1(1), FDPS(1), GGPS1(1), IDI1(2), SQLE(1) 3243017 6 5 6 0 0 0 4 0 2 0 0.227 0.284 1.000 132 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD28(1), CD4(1), HLA-DRA(3), HLA-DRB1(1) 1812037 6 4 6 1 1 1 0 3 1 0 0.359 0.306 1.000 133 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 FUT8(6), ST3GAL1(2), ST3GAL2(1), ST3GAL3(2), ST3GAL4(3) 6001895 14 13 14 3 5 2 3 2 2 0 0.264 0.311 1.000 134 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(7), GABRA2(2), GABRA3(2), GABRA4(6), GABRA5(1), GABRA6(4) 6029315 22 16 22 6 5 5 2 7 3 0 0.299 0.311 1.000 135 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCL11(2), CCL5(1), CCR3(1), HLA-DRA(3), HLA-DRB1(1), IL3(1), IL5(1) 2322073 10 6 10 3 2 2 0 4 2 0 0.491 0.321 1.000 136 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(2), HTR2C(3), PLCB1(3), TUB(4) 5455663 12 9 12 3 4 2 0 5 1 0 0.371 0.331 1.000 137 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(5), LPO(5), MPO(2), PRDX1(1), TPO(6), TYR(4) 7359075 23 13 23 5 9 7 1 5 0 1 0.0660 0.340 1.000 138 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(4), DLD(1), FH(1), IDH2(20), IDH3B(1), OGDH(1), PC(2), PDHA1(5), PDHA2(4), PDHB(1), PDK1(2), PDK3(3), PDK4(1), PDP2(2), SDHA(4), SDHC(2), SUCLG2(1) 21635043 55 42 36 12 7 18 9 15 6 0 0.0270 0.340 1.000 139 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(4), GALNT10(1), GALNT2(2), GALNT3(1), GALNT4(3), GALNT6(3), GALNT8(1), GALNT9(2), ST3GAL1(2), ST3GAL2(1), ST3GAL4(3), WBSCR17(5) 11013829 28 18 28 5 10 4 3 8 3 0 0.0910 0.348 1.000 140 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 CEBPB(1), CSNK2A1(2), ELK1(3), FOS(1), IL6(1), IL6R(1), IL6ST(3), JAK1(1), JAK2(4), JAK3(3), MAPK3(1), PTPN11(7), RAF1(1), SHC1(1), SOS1(4), SRF(2), STAT3(2) 18217559 38 25 36 7 6 8 2 14 7 1 0.0611 0.378 1.000 141 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(2), ANKRD1(1), DUSP14(1), EIF4E(2), HBEGF(1), IFRD1(2), IL18(3), IL1R1(2), NR4A3(1), WDR1(1) 8196234 16 12 16 2 5 1 2 4 4 0 0.161 0.388 1.000 142 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNB1(1), IL10(1), IL12B(2), IL15(2), IL16(8), IL18(3), IL3(1), IL5(1), IL6(1), IL9(1), TNF(1) 7573570 22 15 22 5 3 2 4 9 4 0 0.329 0.390 1.000 143 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 AANAT(1), ACHE(2), CHAT(4), DBH(3), DDC(2), GAD1(2), GAD2(1), HDC(2), MAOA(2), PAH(2), TH(3), TPH1(3) 10957299 27 16 27 6 11 8 0 6 2 0 0.0554 0.394 1.000 144 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(2), COL4A2(4), COL4A4(4), COL4A5(8), COL4A6(6), F10(1), F12(1), F2(3), F2R(2), F5(7), F8(18), F9(3), FGA(6), FGB(1), FGG(1), KLKB1(5), PROS1(1), SERPINC1(1), SERPING1(3) 33846408 77 49 77 16 20 13 13 19 11 1 0.00743 0.399 1.000 145 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(3), CKM(2), EIF4E(2), FBL(2), LDHA(1), LDHB(2), LDHC(1), NCL(2) 6807778 15 9 15 3 3 4 1 4 3 0 0.240 0.404 1.000 146 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(3), ARHGAP5(2), ARHGDIB(1), CASP1(4), CASP8(2), CYCS(2), GZMB(1), PRF1(3) 9820796 18 13 18 4 5 5 2 6 0 0 0.239 0.405 1.000 147 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(1), CDO1(1), GAD1(2), GAD2(1), GGT1(2) 4384590 7 6 7 0 2 1 2 2 0 0 0.0978 0.409 1.000 148 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(2), CHAT(4), PDHA1(5), PDHA2(4) 5311617 15 10 14 4 2 7 1 3 2 0 0.181 0.413 1.000 149 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(4), TPI1(1) 1258225 5 2 5 0 0 3 0 2 0 0 0.195 0.421 1.000 150 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 B3GALT1(2), B3GALT2(1), B3GALT5(1), B3GNT5(4), FUT2(2), ST3GAL3(2), ST3GAL4(3) 5498489 15 10 15 3 7 0 1 5 2 0 0.231 0.438 1.000 151 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ASL(2), CPS1(3), GLS(2), GLUD1(4), GOT1(2) 5952610 13 7 13 2 2 1 0 5 5 0 0.415 0.455 1.000 152 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(3), GAD1(2), HDC(2), TH(3), TPH1(3) 4587198 13 8 13 2 7 3 0 2 1 0 0.0691 0.455 1.000 153 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 CASP8(2), CFL1(1), CFLAR(1) 2960244 4 4 4 0 0 1 1 1 1 0 0.228 0.457 1.000 154 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(1), PGLYRP2(2) 1387798 3 3 3 1 2 0 0 1 0 0 0.732 0.482 1.000 155 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(5), PDXK(1), PSAT1(2) 3702602 8 6 8 3 3 3 0 2 0 0 0.560 0.489 1.000 156 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 CAPNS1(1), CAPNS2(1), EGF(7), EGFR(45), ITGA1(2), ITGB1(2), MAPK1(2), MAPK3(1), MYL2(2), MYLK(5), PRKACG(1), PRKAR1A(2), PTK2(2), TLN1(5) 24924968 78 51 61 16 19 16 10 25 7 1 0.0102 0.489 1.000 157 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAD(2), ALAS1(1), ALAS2(1), CPO(2), FECH(1), HBA2(1), HBB(1), UROD(1), UROS(1) 5987987 11 7 11 2 4 2 1 3 1 0 0.215 0.495 1.000 158 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 MTMR1(4), MTMR2(3), MTMR6(1), NFS1(3), THTPA(2) 4887224 13 6 13 2 1 3 2 5 2 0 0.308 0.505 1.000 159 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(2), GOT1(2), TAT(1), TYR(4) 3592854 9 6 9 3 4 0 1 4 0 0 0.679 0.513 1.000 160 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(3), IL4R(2), JAK1(1), JAK2(4), TYK2(7) 8009960 17 10 17 2 5 0 3 5 4 0 0.103 0.514 1.000 161 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(3), IL4R(2), JAK1(1), JAK2(4), TYK2(7) 8009960 17 10 17 2 5 0 3 5 4 0 0.103 0.514 1.000 162 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 GUSB(3), UCHL3(1), UGDH(1), UGT1A1(5), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A5(2), UGT1A6(2), UGT1A7(2), UGT2B15(2), UGT2B4(4) 13413175 27 19 26 5 7 3 6 10 1 0 0.0806 0.516 1.000 163 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 50 ACOX1(2), APOA1(1), CD36(4), CITED2(1), CREBBP(9), DUSP1(1), EHHADH(1), EP300(5), HSD17B4(2), LPL(2), MAPK1(2), MAPK3(1), ME1(1), NCOA1(2), NCOR1(8), NCOR2(7), NFKBIA(2), NR1H3(5), NR2F1(1), NRIP1(2), PDGFA(1), PIK3CA(50), PIK3R1(23), PPARA(3), PRKACG(1), PRKAR1A(2), PRKCA(5), PTGS2(2), RB1(6), RELA(1), RXRA(1), STAT5A(1), STAT5B(2), TNF(1) 48256440 158 105 129 32 23 27 30 29 45 4 0.00756 0.519 1.000 164 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 47 INPP4A(1), INPP4B(4), INPP5B(3), INPPL1(5), IPMK(2), ISYNA1(2), ITPK1(3), MINPP1(1), OCRL(5), PI4KA(7), PI4KB(2), PIK3C3(2), PIK3CA(50), PIK3CB(3), PIK3CD(3), PIK3CG(5), PIP4K2A(1), PIP4K2B(1), PIP4K2C(2), PIP5K1B(1), PIP5K1C(1), PLCB1(3), PLCB2(4), PLCB3(4), PLCB4(3), PLCD1(1), PLCD3(2), PLCE1(8), PLCG1(6), PLCG2(9), PLCZ1(4), PTEN(25), PTPMT1(1), SYNJ1(6), SYNJ2(8) 56683833 188 116 164 35 32 39 32 48 37 0 0.000119 0.523 1.000 165 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(2), GCK(2), GFPT1(4), GNPDA1(2), HEXA(1), HEXB(1), HK1(4), HK2(3), HK3(3), PGM3(1), RENBP(3), UAP1(2) 12926250 28 19 28 4 8 7 4 6 3 0 0.0273 0.531 1.000 166 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 ALAD(2), BLVRA(2), CP(3), EPRS(3), FECH(1), GUSB(3), HCCS(4), PPOX(1), UGT1A1(5), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A5(2), UGT1A6(2), UGT1A7(2), UGT2B15(2), UGT2B4(4), UROD(1), UROS(1) 20873622 43 29 42 8 11 5 11 15 1 0 0.0370 0.532 1.000 167 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 ASAH1(1), BFAR(1), BRAF(6), CREB1(1), MAPK1(2), RAF1(1), SNX13(1), TERF2IP(1) 8503172 14 9 13 1 1 0 4 5 4 0 0.0834 0.533 1.000 168 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 INPP4A(1), INPP4B(4), INPPL1(5), OCRL(5), PIK3C2A(4), PIK3C2B(2), PIK3C2G(1), PIK3CA(50), PIK3CB(3), PIK3CG(5), PLCB1(3), PLCB2(4), PLCB3(4), PLCB4(3), PLCD1(1), PLCG1(6), PLCG2(9) 34139560 110 80 88 25 17 25 23 26 19 0 0.0151 0.539 1.000 169 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 GLB1(2), GUSB(3), HEXA(1), HEXB(1), HGSNAT(2), HPSE(2), HPSE2(3), HYAL1(3), HYAL2(1), IDS(2), LCT(10), NAGLU(3), SPAM1(3) 15626810 36 22 36 6 16 2 6 6 6 0 0.0400 0.542 1.000 170 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 FABP6(1), NR1H3(5), RXRA(1) 4151467 7 6 6 2 3 2 2 0 0 0 0.339 0.560 1.000 171 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 FUT2(2), FUT5(3), FUT6(2), ST3GAL3(2) 3878740 9 6 9 2 6 1 0 1 1 0 0.342 0.560 1.000 172 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(7), ATP4B(2), ATP6AP1(2), ATP6V0C(1), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1G3(2), ATP6V1H(1), ATP7A(9), ATP7B(4), COX10(3), COX6B1(1), COX7A1(1), COX7B(3), NDUFA10(3), NDUFB5(1), NDUFS1(2), NDUFV1(2), NDUFV2(1), SDHA(4), SHMT1(2), UQCRC1(3), UQCRH(2) 29114842 61 36 59 9 10 10 13 19 8 1 0.00266 0.561 1.000 173 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 65 ADAM10(2), ATP6AP1(2), ATP6V0A2(1), ATP6V0C(1), ATP6V0D2(2), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1E2(2), ATP6V1G3(2), ATP6V1H(1), CCL5(1), CSK(1), EGFR(45), F11R(1), GIT1(2), HBEGF(1), IKBKB(1), JAM2(4), JAM3(2), MAPK10(1), MAPK12(2), MAPK13(1), MAPK8(2), MAPK9(1), MET(10), NFKB1(1), NFKB2(1), NFKBIA(2), NOD1(1), PAK1(2), PLCG1(6), PLCG2(9), PTPN11(7), PTPRZ1(12), RAC1(1), RELA(1), TCIRG1(2), TJP1(5) 53580484 143 84 123 27 28 30 18 41 25 1 0.000284 0.571 1.000 174 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(2), MBTPS1(2), MBTPS2(3), SCAP(2), SREBF1(6), SREBF2(3) 9136512 18 12 18 4 4 3 3 5 3 0 0.235 0.574 1.000 175 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 APEX1(2), CREBBP(9), DFFA(2), GZMA(1), GZMB(1), HMGB2(1), PRF1(3), SET(1) 8065853 20 12 20 3 9 1 2 5 3 0 0.117 0.592 1.000 176 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(1), F12(1), F13B(4), F2(3), F5(7), F7(2), F8(18), F9(3), FGA(6), FGB(1), FGG(1), LPA(7), PLAT(1), PLG(4), SERPINB2(2), SERPINE1(2), SERPINF2(1), VWF(7) 26922907 71 40 71 16 18 11 10 20 12 0 0.0270 0.596 1.000 177 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 ATP6V0C(1), GGT1(2), SHMT1(2) 3177317 5 4 5 1 2 1 2 0 0 0 0.351 0.609 1.000 178 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 CHIA(2), CMAS(2), GFPT1(4), GFPT2(3), GNPDA1(2), GNPNAT1(2), HEXA(1), HEXB(1), HK1(4), HK2(3), HK3(3), MTMR1(4), MTMR2(3), MTMR6(1), NANS(1), PGM3(1), RENBP(3), UAP1(2) 21873426 42 29 42 7 9 9 7 10 7 0 0.0302 0.615 1.000 179 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT2(1), AGPAT3(1), AGPAT6(1), AGPS(3), ENPP2(3), ENPP6(1), PAFAH1B1(4), PAFAH1B3(1), PAFAH2(2), PLA2G12B(1), PLA2G2D(1), PLA2G3(4), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLD1(7), PPAP2A(2), PPAP2C(1) 17651031 40 22 40 7 8 6 8 13 5 0 0.0408 0.623 1.000 180 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(3), ME1(1), PC(2), PDHA1(5), SLC25A1(1) 7069209 12 11 11 3 1 3 0 4 4 0 0.361 0.627 1.000 181 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD28(1), CD4(1), HLA-DRA(3), HLA-DRB1(1), IL10(1) 3033626 7 5 7 3 1 1 1 3 1 0 0.637 0.631 1.000 182 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 42 DAXX(2), EGF(7), EGFR(45), ETS1(3), FOS(1), HOXA7(2), IKBKB(1), MAP2K3(3), MAP3K1(3), MAP3K5(3), MAPK1(2), MAPK13(1), MAPK3(1), MAPK8(2), NFKB1(1), NFKBIA(2), PPP2CA(4), PRKCA(5), PRKCG(2), PRKCH(3), PRKCQ(2), RAF1(1), RELA(1), RIPK1(3), TNF(1), TNFRSF1B(2), TRAF2(2) 37425317 105 68 88 23 26 27 9 27 13 3 0.00146 0.632 1.000 183 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 74 AKT1(1), BTK(2), FCER1A(2), FYN(1), GAB2(2), IL3(1), IL5(1), INPP5D(2), KRAS(3), LAT(2), LCP2(1), MAP2K2(1), MAP2K3(3), MAPK1(2), MAPK10(1), MAPK12(2), MAPK13(1), MAPK3(1), MAPK8(2), MAPK9(1), NRAS(4), PDK1(2), PIK3CA(50), PIK3CB(3), PIK3CD(3), PIK3CG(5), PIK3R1(23), PIK3R2(1), PIK3R3(1), PIK3R5(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(4), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLCG1(6), PLCG2(9), PRKCA(5), RAC1(1), RAC2(1), RAF1(1), SOS1(4), SOS2(5), TNF(1), VAV1(5), VAV2(2), VAV3(2) 54992666 180 117 151 34 31 33 36 37 40 3 0.000317 0.633 1.000 184 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CD36(4), FOS(1), FYN(1), THBS1(4) 5643849 10 7 10 3 3 4 2 0 1 0 0.295 0.633 1.000 185 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(2), HLCS(3) 2346946 5 3 5 2 1 1 0 2 1 0 0.649 0.636 1.000 186 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 CYCS(2), SDHA(4), SDHC(2), UQCRC1(3) 5041064 11 7 10 2 2 2 4 3 0 0 0.228 0.681 1.000 187 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(2), CYP2E1(1), PTGS1(2), PTGS2(2) 4079876 7 6 7 2 4 0 0 2 1 0 0.690 0.684 1.000 188 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(4), LCT(10), MPI(1), PYGL(5), PYGM(1), TPI1(1) 10224406 22 13 22 4 5 4 3 4 6 0 0.0639 0.685 1.000 189 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(2), TAT(1) 2007314 3 2 3 1 1 0 1 1 0 0 0.729 0.687 1.000 190 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 18 APAF1(3), BAK1(2), BAX(1), BIRC2(2), CASP8(2), CYCS(2), DFFA(2), DIABLO(1) 10226683 15 11 15 3 4 4 2 4 1 0 0.191 0.693 1.000 191 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(4), ALDOA(1), ALDOB(1), TPI1(1) 2987206 7 3 7 0 0 4 0 2 1 0 0.101 0.693 1.000 192 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(1), JAK2(4), JAK3(3), MAPK1(2), MAPK3(1), STAT3(2), TYK2(7) 8962076 20 10 20 3 6 0 2 6 5 1 0.164 0.712 1.000 193 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(2), PLCD1(1), PRKCA(5) 3758369 8 5 8 3 3 0 1 3 0 1 0.602 0.715 1.000 194 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(2), CHRNA1(4) 2482127 6 6 6 3 2 1 1 1 1 0 0.706 0.716 1.000 195 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(1), CAT(3), EPX(5), LPO(5), MPO(2), MTHFR(6), SHMT1(2), TPO(6) 8843261 30 13 30 7 11 9 3 5 2 0 0.0541 0.718 1.000 196 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 DHRS2(2), DHRS3(1), DHRS7(1), DHRSX(1), LCMT1(2), LCMT2(1), METTL2B(3), METTL6(1), PRMT2(2), PRMT5(4), PRMT6(1), PRMT7(1), PRMT8(4), WBSCR22(2) 11432026 26 12 25 5 7 3 6 6 4 0 0.0957 0.719 1.000 197 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(8), CDC25A(1), CDC25B(1), CHEK1(3), MYT1(7), WEE1(1), YWHAH(1) 10510208 22 13 22 6 3 2 2 4 11 0 0.688 0.719 1.000 198 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOA(1), ALDOB(1), DLD(1), ENO1(2), ENO2(1), ENO3(1), FBP1(1), FBP2(1), G6PC(7), GAPDHS(1), GCK(2), GOT1(2), GPI(2), HK1(4), HK2(3), HK3(3), LDHA(1), LDHAL6B(1), LDHB(2), LDHC(1), PC(2), PCK1(3), PDHA1(5), PDHA2(4), PDHB(1), PFKL(4), PFKP(1), PGAM2(1), PGK1(2), PKLR(3), TNFAIP1(2), TPI1(1) 32377455 67 40 66 7 25 20 3 10 9 0 6.14e-06 0.721 1.000 199 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3D(1) 868472 1 1 1 1 0 1 0 0 0 0 0.898 0.724 1.000 200 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 69 AKT1(1), KDR(6), KRAS(3), MAP2K2(1), MAPK1(2), MAPK12(2), MAPK13(1), MAPK3(1), MAPKAPK2(1), MAPKAPK3(1), NFAT5(3), NFATC1(2), NFATC2(5), NFATC3(2), NFATC4(3), NOS3(7), NRAS(4), PIK3CA(50), PIK3CB(3), PIK3CD(3), PIK3CG(5), PIK3R1(23), PIK3R2(1), PIK3R3(1), PIK3R5(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(4), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLCG1(6), PLCG2(9), PPP3CA(1), PPP3CC(1), PRKCA(5), PRKCG(2), PTGS2(2), PTK2(2), RAC1(1), RAC2(1), RAF1(1), SH2D2A(1), SHC2(1), VEGFA(2) 54863572 180 113 151 35 33 29 40 33 42 3 0.000295 0.731 1.000 201 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(2), GLS(2), GLUD1(4), OAT(1) 4198168 9 6 9 3 2 1 0 4 2 0 0.636 0.735 1.000 202 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP1(1), ACPP(4), ALPI(1), ALPP(5), ALPPL2(2), CYP3A4(3), CYP3A7(1), DHRS2(2), DHRS3(1), DHRS7(1), DHRSX(1), PON1(2), PON3(1) 13713969 25 21 24 5 12 1 2 4 6 0 0.119 0.740 1.000 203 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 TGDS(1), UGDH(1), UXS1(2) 2914616 4 3 4 0 0 1 2 0 1 0 0.317 0.752 1.000 204 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 SRP68(2), SRP72(3), SRPR(5) 5765664 10 5 10 1 4 0 2 2 2 0 0.238 0.755 1.000 205 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(4), ACE2(5), AGT(2), AGTR2(3), ANPEP(3), CMA1(2), CTSA(1), CTSG(2), ENPEP(6), LNPEP(1), MME(2), NLN(1), REN(2), THOP1(5) 16156609 39 25 38 10 11 6 6 10 6 0 0.169 0.761 1.000 206 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 CALM3(1), CDKN1A(1), MARCKS(1), NFATC1(2), NFATC2(5), NFATC3(2), NFATC4(3), PLCG1(6), PPP3CA(1), PPP3CC(1), PRKCA(5), SP3(4), SYT1(1) 16012806 33 21 32 8 9 4 5 9 5 1 0.169 0.771 1.000 207 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 GGT1(2), SHMT1(2) 4188970 4 4 4 1 1 1 2 0 0 0 0.463 0.775 1.000 208 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAD(2), ALAS1(1), ALAS2(1), FECH(1), PPOX(1), UROD(1), UROS(1) 5773801 8 5 8 1 2 2 1 3 0 0 0.243 0.777 1.000 209 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDHB(1), BCKDK(3), CBS(4), CTH(1), MUT(1) 3745831 10 4 10 0 2 5 0 2 1 0 0.0264 0.777 1.000 210 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(12), ACAT2(1), ADH5(1), ALDH1A1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), DLD(1), LDHA(1), LDHB(2), LDHC(1), LDHD(1), ME1(1), ME2(1), ME3(1), PC(2), PCK1(3), PDHA1(5), PDHA2(4), PDHB(1), PKLR(3) 28207645 55 36 54 11 15 15 5 11 9 0 0.0187 0.778 1.000 211 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(2), HK1(4), HK2(3), HK3(3), PGM3(1), TGDS(1) 7788788 14 9 14 2 6 4 2 1 1 0 0.0618 0.786 1.000 212 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(5), LPO(5), MPO(2), TPO(6) 6374007 18 11 18 5 8 7 1 2 0 0 0.142 0.790 1.000 213 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(3), PARK2(1), SNCA(1), SNCAIP(1), UBE2G2(1), UBE2L6(1) 4918182 8 8 8 3 5 1 0 1 1 0 0.481 0.792 1.000 214 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT2(1), OXCT1(1) 2581413 2 2 2 0 0 1 0 1 0 0 0.592 0.793 1.000 215 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(1), RDH5(1) 2977776 2 2 2 1 0 2 0 0 0 0 0.705 0.799 1.000 216 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 LCMT1(2), LCMT2(1), METTL2B(3), METTL6(1), PCYT1B(1), PRMT2(2), PRMT5(4), PRMT6(1), PRMT7(1), PRMT8(4), WBSCR22(2) 10700515 22 10 22 5 4 3 5 6 4 0 0.210 0.804 1.000 217 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 CBS(4), CTH(1), GGT1(2), MARS(5), MARS2(2), SCLY(2), SEPHS1(1) 9435296 17 9 17 1 3 6 3 3 2 0 0.0123 0.808 1.000 218 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(10), MAP2(7), PPP1CA(1), PPP2CA(4), PRKACG(1), PRKAG1(1) 13881910 24 12 24 4 4 4 2 8 6 0 0.224 0.811 1.000 219 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 C1GALT1(1), GALNT1(4), GALNT10(1), GALNT11(2), GALNT12(3), GALNT13(2), GALNT14(4), GALNT2(2), GALNT3(1), GALNT4(3), GALNT5(3), GALNT6(3), GALNT8(1), GALNT9(2), GALNTL5(1), GCNT3(1), GCNT4(2), OGT(8), ST3GAL1(2), ST3GAL2(1), ST6GALNAC1(2), WBSCR17(5) 24666893 54 33 53 11 16 11 4 16 7 0 0.0495 0.815 1.000 220 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(12), CPT1A(1), LEPR(2), PRKAA1(3), PRKAA2(2), PRKAG1(1), PRKAG2(1) 11046208 22 10 22 2 6 3 1 7 5 0 0.0364 0.817 1.000 221 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CYP11A1(4), CYP11B2(1), HSD3B1(2), HSD3B2(1) 5263021 8 8 8 3 4 0 1 1 2 0 0.522 0.820 1.000 222 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(3), IL5(1), MAF(3), MAP2K3(3), NFATC1(2), NFATC2(5), PRKACG(1), PRKAR1A(2) 9304757 20 13 20 6 8 1 3 6 2 0 0.311 0.825 1.000 223 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(2), HK1(4), HK2(3), HK3(3), ISYNA1(2), PGM3(1), TGDS(1) 8890894 16 10 16 2 6 5 2 2 1 0 0.0330 0.827 1.000 224 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG5(3), ATG7(3), IFNA21(4), IFNA5(1), IFNA6(1), IFNA7(1), IFNA8(1), PIK3C3(2), PIK3R4(3), PRKAA1(3), PRKAA2(2), ULK1(1), ULK2(5) 16083087 30 13 30 3 6 2 8 9 5 0 0.0124 0.833 1.000 225 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(5), ACO2(4), AFMID(1), HAO1(2), HAO2(1), HYI(2), MTHFD1(2), MTHFD1L(1) 10212064 18 10 18 3 3 5 2 3 5 0 0.172 0.835 1.000 226 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(1), ACADM(2), ACADS(2), ECHS1(2), HADHA(2) 4118875 9 6 9 4 2 1 1 2 3 0 0.655 0.835 1.000 227 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 RAB27A(2), RAB3A(1), RAB9A(1) 3233959 4 3 4 0 2 1 0 1 0 0 0.225 0.838 1.000 228 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT2(1), BDH1(1), BDH2(1), HMGCS1(2), HMGCS2(3), OXCT1(1) 5455379 9 4 9 0 1 3 0 4 1 0 0.0803 0.842 1.000 229 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 GLB1(2), GUSB(3), HEXA(1), HEXB(1), IDS(2), LCT(10), NAGLU(3) 10970400 22 13 22 5 9 2 4 3 4 0 0.182 0.844 1.000 230 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CTH(1), GOT1(2), LDHA(1), LDHB(2), LDHC(1) 5226256 7 4 7 1 1 4 0 2 0 0 0.259 0.846 1.000 231 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1D1(1), CYP11A1(4), CYP11B1(1), CYP11B2(1), HSD3B1(2), HSD3B2(1) 7039220 10 9 10 3 4 0 2 1 3 0 0.401 0.852 1.000 232 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1D1(1), CYP11A1(4), CYP11B1(1), CYP11B2(1), HSD3B1(2), HSD3B2(1) 7039220 10 9 10 3 4 0 2 1 3 0 0.401 0.852 1.000 233 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(4), CD44(3), FCGR3A(1), IL1B(2), IL6R(1), SPN(1), TGFB2(2), TNF(1), TNFRSF1B(2), TNFRSF8(2), TNFSF8(2) 9951983 21 13 21 5 9 6 2 2 2 0 0.0957 0.852 1.000 234 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CCNB1(2), CDC25A(1), CDC25B(1), CSK(1), PRKCA(5), PTPRA(4) 7019909 14 7 14 4 6 2 3 2 0 1 0.340 0.853 1.000 235 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNAR1(2), IFNAR2(1), IFNB1(1), JAK1(1), STAT1(2), STAT2(1), TYK2(7) 8277078 15 8 15 4 4 0 1 7 2 1 0.498 0.856 1.000 236 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(1), FUCA1(2), FUCA2(3), GLB1(2), HEXA(1), HEXB(1), LCT(10), MAN2C1(2), MANBA(1), NEU1(1), NEU2(5), NEU3(2) 12590038 31 23 31 8 8 3 6 9 5 0 0.334 0.859 1.000 237 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(2), GNAS(4), PRKACG(1), PRKAR1A(2), PRKCA(5) 7333525 14 11 14 4 6 0 1 5 1 1 0.629 0.861 1.000 238 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 TGDS(1), UGDH(1), UGP2(1), UXS1(2) 3718351 5 3 5 0 0 1 2 1 1 0 0.259 0.864 1.000 239 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 MMP9(2), RECK(3), TIMP1(1), TIMP3(1), TIMP4(2) 5742287 9 6 9 2 3 2 1 1 2 0 0.354 0.867 1.000 240 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(8), PRKACG(1), PRKAG1(1) 7703463 10 6 10 3 2 0 1 5 2 0 0.669 0.870 1.000 241 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT1(1), BCR(3), BLNK(2), BTK(2), CD19(1), CD22(3), CD81(2), CR2(4), CSK(1), DAG1(1), FLOT2(3), INPP5D(2), ITPR1(4), ITPR2(12), ITPR3(13), MAP4K1(1), MAPK1(2), MAPK3(1), NFATC1(2), NFATC2(5), PDK1(2), PIK3CA(50), PIK3CD(3), PIK3R1(23), PLCG2(9), PPP1R13B(1), PPP3CA(1), PPP3CC(1), PTPRC(7), RAF1(1), SHC1(1), SOS1(4), SOS2(5), VAV1(5) 56346712 178 115 151 36 36 31 32 40 36 3 0.000630 0.874 1.000 242 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(3), ICAM1(2), ITGA4(5), ITGAL(2), ITGB1(2), ITGB2(1), SELE(6) 9231031 21 17 20 8 8 4 6 1 2 0 0.412 0.875 1.000 243 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(1), AASDHPPT(1) 3609161 2 2 2 0 0 0 0 1 1 0 0.606 0.876 1.000 244 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 FBP2(1), G6PC(7), GAA(5), GANAB(4), GCK(2), GLA(2), GLB1(2), HK1(4), HK2(3), HK3(3), LCT(10), MGAM(7), PFKP(1), PGM3(1) 24783286 52 29 52 10 29 6 4 9 4 0 0.00949 0.876 1.000 245 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(1), ATP6V0C(1), CAT(3), EPX(5), LPO(5), MPO(2), PRDX1(1), SHMT1(2), TPO(6) 9002295 26 12 26 7 10 9 2 3 1 1 0.0825 0.876 1.000 246 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(5), ACO2(4), HAO1(2), HAO2(1), HYI(2), MTHFD1(2), MTHFD1L(1) 9752655 17 9 17 3 3 5 2 3 4 0 0.175 0.876 1.000 247 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(1), PSMA2(2), PSMA3(1), PSMA4(1), PSMB1(1), PSMB2(1), PSMB3(1), PSMB4(1), PSMB5(1), PSMB6(1), PSMB8(1) 6659547 12 5 12 3 3 3 2 3 1 0 0.415 0.878 1.000 248 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 CBS(4), CTH(1), GGT1(2), LCMT1(2), LCMT2(1), MARS(5), MARS2(2), METTL2B(3), METTL6(1), PRMT2(2), PRMT5(4), PRMT6(1), PRMT7(1), PRMT8(4), SCLY(2), SEPHS1(1), WBSCR22(2) 19003661 38 18 38 6 6 9 8 9 6 0 0.0158 0.887 1.000 249 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(1), AASDH(3), AASDHPPT(1) 5320402 5 4 5 1 0 0 1 2 2 0 0.604 0.890 1.000 250 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNB1(2), CCNH(2), CDC25A(1), CDC25B(1), SHH(1), XPO1(1) 6620167 8 6 8 3 3 4 1 0 0 0 0.496 0.890 1.000 251 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ERBB4(5), NRG2(1), PRKCA(5) 6884087 11 7 11 2 3 1 2 3 1 1 0.288 0.890 1.000 252 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTR2(2), ACTR3(1), ARPC1A(1), ARPC1B(2), ARPC3(1), NCK1(2), NCKAP1(4), NTRK1(2), RAC1(1), WASF1(1), WASF2(1), WASF3(3), WASL(2) 11646456 23 12 23 5 3 4 3 9 4 0 0.208 0.892 1.000 253 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 AKR1B10(2), DHRS2(2), DHRS3(1), DHRS7(1), DHRSX(1), HSD3B7(1), PON1(2), PON3(1) 6832399 11 7 10 4 5 0 1 3 2 0 0.671 0.894 1.000 254 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CDO1(1), CTH(1), GOT1(2), LDHA(1), LDHAL6B(1), LDHB(2), LDHC(1), SDS(1), SULT1B1(2), SULT1C2(3) 9563792 15 8 15 4 3 5 1 4 2 0 0.388 0.896 1.000 255 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(3), BAK1(2), BAX(1), BCL2L11(1), CES1(1) 8260191 8 6 8 1 3 1 1 2 1 0 0.225 0.898 1.000 256 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 CREB1(1), FOS(1), MAPK1(2), MAPK8(2), NFE2L2(1), PRKCA(5) 6757602 12 8 12 3 2 2 3 1 3 1 0.230 0.898 1.000 257 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 ALDOA(1), CTSD(1), ESR1(2), GREB1(7), MTA3(2), PDZK1(1), TUBA8(1) 8297612 15 8 15 3 6 3 1 3 2 0 0.181 0.902 1.000 258 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(1), PSMA2(2), PSMA3(1), PSMA4(1), PSMB1(1), PSMB2(1), PSMB3(1), PSMB4(1), PSMB5(1), PSMB6(1), PSMC3(1), RPN1(1), RPN2(1) 9833552 14 7 14 4 4 4 2 2 2 0 0.453 0.905 1.000 259 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM3(1), CAMK1(1), CAMK1G(1), CAMK2A(2), CAMK2D(1), CAMK2G(2), CAMK4(2), CAMKK1(1), CAMKK2(2), CREB1(1), SYT1(1) 8814705 15 7 15 4 4 5 3 0 3 0 0.201 0.906 1.000 260 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4) 6095720 14 8 14 5 6 2 2 2 2 0 0.470 0.908 1.000 261 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4) 6095720 14 8 14 5 6 2 2 2 2 0 0.470 0.908 1.000 262 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B10(2), G6PC(7), G6PC2(1), GAA(5), GANC(5), GCK(2), GLA(2), GLB1(2), HK1(4), HK2(3), HK3(3), HSD3B7(1), LCT(10), MGAM(7), PFKL(4), PFKP(1), PGM3(1), UGP2(1) 29397326 61 33 61 12 32 6 5 13 5 0 0.00682 0.913 1.000 263 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 GUSB(3), UGDH(1), UGP2(1), UGT1A1(5), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A5(2), UGT1A6(2), UGT1A7(2), UGT2A1(5), UGT2A3(6), UGT2B10(3), UGT2B11(3), UGT2B15(2), UGT2B17(2), UGT2B28(2), UGT2B4(4), UGT2B7(2) 20827374 50 34 49 12 12 5 10 21 2 0 0.134 0.913 1.000 264 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSA(1), ARSD(3), ARSE(3), ASAH1(1), GALC(1), GLA(2), GLB1(2), LCT(10), NEU1(1), NEU2(5), NEU3(2), PPAP2A(2), PPAP2C(1), SMPD1(1), SMPD2(1), SPTLC1(2), SPTLC2(2), UGCG(2) 18459515 42 23 42 10 14 4 8 12 3 1 0.133 0.916 1.000 265 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(12), ACACB(11), ACAT2(1), ACSS1(1), ACSS2(4), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH7A1(2), DLD(1), LDHA(1), LDHAL6B(1), LDHB(2), LDHC(1), LDHD(1), ME1(1), ME2(1), ME3(1), PC(2), PCK1(3), PDHA1(5), PDHA2(4), PDHB(1), PKLR(3) 35675658 72 47 71 15 24 17 6 14 11 0 0.00917 0.919 1.000 266 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(1), F2(3), F2R(2), F5(7), F7(2), FGA(6), FGB(1), FGG(1), PROS1(1), SERPINC1(1) 12501458 25 20 25 8 9 1 6 7 2 0 0.404 0.921 1.000 267 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CD28(1), CD3D(1), CD4(1) 2453023 3 2 3 2 1 1 0 1 0 0 0.810 0.922 1.000 268 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1A(2), ADRA1B(2), ADRA2A(1), ADRA2C(1), ADRB2(1), CHRM1(2), CHRM3(3), CHRM4(1), CHRM5(4), DRD3(2), DRD5(3), HRH1(3), HTR1A(1), HTR1B(1), HTR1D(2), HTR1E(1), HTR1F(2), HTR2A(1), HTR2B(2), HTR2C(3), HTR4(1), HTR5A(4), HTR6(1), HTR7(1) 19607700 45 28 45 11 20 8 4 7 6 0 0.0151 0.923 1.000 269 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 AKR1A1(2), ECHS1(2), EHHADH(1), HADHA(2), SDS(1) 3678320 8 5 8 6 3 0 2 1 2 0 0.883 0.924 1.000 270 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSA(1), ARSD(3), ARSE(3), ASAH1(1), B4GALT6(1), DEGS1(2), DEGS2(2), GALC(1), GLA(2), GLB1(2), LCT(10), NEU1(1), NEU2(5), NEU3(2), PPAP2A(2), PPAP2C(1), SGMS2(2), SGPP1(1), SGPP2(1), SMPD1(1), SMPD2(1), SMPD3(2), SMPD4(1), SPTLC1(2), SPTLC2(2), UGCG(2), UGT8(1) 27198398 55 28 55 12 17 5 11 17 4 1 0.0597 0.927 1.000 271 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH7A1(2), UGDH(1) 6500331 16 8 16 4 8 2 2 2 2 0 0.236 0.929 1.000 272 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(2), AXIN1(1), BTRC(1), CCND1(4), CREBBP(9), CSNK1A1(2), CSNK1D(1), CSNK2A1(2), CTBP1(5), CTNNB1(3), FZD1(2), NLK(1), PPP2CA(4), WIF1(2) 22377907 39 20 39 6 10 5 5 11 8 0 0.0394 0.930 1.000 273 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(2), ATP6V0C(1), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1G3(2), ATP6V1H(1), SHMT1(2) 11486061 13 9 13 3 3 5 3 1 0 1 0.198 0.931 1.000 274 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(2), ATP6V0C(1), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1G3(2), ATP6V1H(1), SHMT1(2) 11486061 13 9 13 3 3 5 3 1 0 1 0.198 0.931 1.000 275 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(2), ATP6V0C(1), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1G3(2), ATP6V1H(1), SHMT1(2) 11486061 13 9 13 3 3 5 3 1 0 1 0.198 0.931 1.000 276 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 IL6(1), LPL(2) 4068509 3 3 3 0 0 0 0 3 0 0 0.585 0.934 1.000 277 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 EPHA4(7), EPHB1(2), FYN(1), ITGA1(2), ITGB1(2), L1CAM(7), SELP(2) 12040343 23 11 23 7 6 5 3 8 1 0 0.357 0.934 1.000 278 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(5), ABCB11(1), ABCB4(6), ABCC1(5), ABCC3(5) 10940122 22 11 22 7 4 3 3 8 3 1 0.490 0.936 1.000 279 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(9), EP300(5), ESR1(2), MAPK1(2), MAPK3(1), PELP1(2) 11260876 21 10 20 4 9 1 2 5 3 1 0.161 0.937 1.000 280 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(2), CD3D(1), CD4(1), CREBBP(9), CSK(1), GNAS(4), HLA-DRA(3), HLA-DRB1(1), LCK(1), PRKACG(1), PRKAR1A(2), PTPRC(7), ZAP70(5) 17549534 38 24 38 9 12 6 2 13 5 0 0.218 0.937 1.000 281 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(2), CD3D(1), CD4(1), CREBBP(9), CSK(1), GNAS(4), HLA-DRA(3), HLA-DRB1(1), LCK(1), PRKACG(1), PRKAR1A(2), PTPRC(7), ZAP70(5) 17549534 38 24 38 9 12 6 2 13 5 0 0.218 0.937 1.000 282 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(1), ACACA(12), ACACB(11), ACADM(2), ACAT2(1), ACSS1(1), ACSS2(4), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH6A1(4), ALDH7A1(2), ECHS1(2), EHHADH(1), HADHA(2), HIBCH(1), LDHA(1), LDHAL6B(1), LDHB(2), LDHC(1), MLYCD(3), MUT(1), PCCA(1), PCCB(3), SUCLG2(1) 30258890 71 37 71 17 22 16 6 16 11 0 0.0395 0.938 1.000 283 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(3), BIRC2(2), CASP8(2), DFFA(2), GZMB(1), PRF1(3), SCAP(2), SREBF1(6), SREBF2(3) 13921178 24 18 24 6 9 6 4 4 1 0 0.196 0.938 1.000 284 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(2), AGPAT2(1), AGPAT3(1), AGPS(3), CDS2(2), CHAT(4), CHKB(1), CLC(1), DGKA(3), DGKB(2), DGKD(3), DGKE(1), DGKG(2), DGKH(3), DGKQ(2), DGKZ(1), ETNK1(1), GNPAT(1), LGALS13(3), LYPLA1(1), PAFAH1B1(4), PAFAH2(2), PCYT1B(1), PISD(1), PLA2G3(4), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLCB2(4), PLCG1(6), PLCG2(9), PPAP2A(2), PPAP2C(1) 37972350 79 48 78 17 24 18 10 16 11 0 0.00998 0.939 1.000 285 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTR2(2), ACTR3(1), ARPC1A(1), ARPC1B(2), ARPC3(1), RAC1(1), WASF1(1), WASL(2) 6205319 11 5 11 2 0 2 1 7 1 0 0.351 0.946 1.000 286 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(1), PSMA2(2), PSMA3(1), PSMA4(1), PSMB1(1), PSMB2(1), PSMB3(1), PSMB4(1), PSMB5(1), PSMB6(1), PSMC2(1), PSMC3(1), PSMD1(1), PSMD11(2), PSMD2(3) 12213032 19 9 19 3 3 8 2 4 2 0 0.108 0.946 1.000 287 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 FOSB(1), GRIA2(2) 2868283 3 2 3 0 1 0 0 2 0 0 0.422 0.947 1.000 288 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 IL1B(2), MST1R(2), TNF(1) 4993252 5 3 5 2 1 3 0 1 0 0 0.538 0.948 1.000 289 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(1), ALDH4A1(2), ALDH5A1(1), CAD(5), CPS1(3), EPRS(3), GAD1(2), GAD2(1), GCLC(1), GFPT1(4), GLS(2), GLS2(1), GLUD1(4), GLUL(1), GOT1(2), GSS(1), NADSYN1(4), PPAT(2), QARS(3) 25273146 43 24 43 7 10 7 6 12 8 0 0.0366 0.948 1.000 290 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 CLOCK(1), CRY1(2), CSNK1E(1), PER1(5) 6500414 9 5 9 3 2 2 1 3 1 0 0.630 0.949 1.000 291 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CD3D(1), CD4(1), IL12B(2), IL12RB1(2), IL12RB2(2), JAK2(4), STAT4(2), TYK2(7) 11215590 21 8 21 6 7 2 3 7 2 0 0.397 0.951 1.000 292 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(2), AR(4), ESR1(2), ESR2(3), ESRRA(2), HNF4A(3), NPM1(2), NR0B1(1), NR1D1(1), NR1D2(1), NR1H2(2), NR1H3(5), NR1I2(1), NR2C2(2), NR2E1(2), NR2F1(1), NR2F2(3), NR3C1(3), NR4A1(1), NR4A2(1), NR5A1(1), NR5A2(1), PGR(4), PPARA(3), PPARG(2), RARB(1), ROR1(3), RORA(1), RORC(1), RXRA(1), RXRG(3), THRA(2), THRB(2), VDR(2) 32068659 69 39 67 15 29 10 11 14 5 0 0.0128 0.953 1.000 293 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 BPNT1(1), SULT1A2(1), SULT2A1(2), SUOX(1) 4665623 5 2 5 5 0 1 0 2 2 0 0.980 0.956 1.000 294 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 ARHGDIB(1), CASP8(2), CFLAR(1), DAXX(2), DFFA(2), FAF1(3), LMNA(2), LMNB2(2), MAP3K1(3), MAPK8(2), PAK1(2), PAK2(2), PRKDC(11), PTPN13(3), RB1(6), RIPK2(1), SPTAN1(5) 30892555 50 29 50 9 10 10 8 11 10 1 0.0473 0.956 1.000 295 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6AP1(2), ATP6V0C(1), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1G3(2), ATP6V1H(1), FDXR(1), SHMT1(2) 12217542 14 9 14 3 4 5 3 1 0 1 0.160 0.957 1.000 296 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNGR2(1), JAK1(1), JAK2(4), STAT1(2) 6245827 8 3 8 4 1 0 1 3 2 1 0.840 0.957 1.000 297 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD3D(1), CD4(1), CD58(1), IL3(1), IL6(1), KITLG(2) 4702666 7 3 7 2 0 1 1 5 0 0 0.603 0.958 1.000 298 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 ATF1(1), BRAF(6), CREB1(1), DUSP4(1), DUSP9(2), EEF2K(2), EIF4E(2), MAP2K2(1), MAP3K8(4), MAPK1(2), MAPK3(1), MKNK1(2), NFKB1(1), RPS6KA1(4), RPS6KA2(3), RPS6KA3(3), SHC1(1), SOS1(4), SOS2(5), TRAF3(1) 22523028 47 24 46 11 12 3 6 16 9 1 0.165 0.958 1.000 299 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(1), ACSS2(4), ADH1A(1), ADH1B(2), ADH5(1), ADH6(3), ADH7(2), ADHFE1(2), AKR1A1(2), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH3B2(2), ALDH7A1(2), ALDOA(1), ALDOB(1), DLD(1), ENO1(2), ENO2(1), ENO3(1), FBP1(1), FBP2(1), G6PC(7), G6PC2(1), GALM(1), GAPDHS(1), GCK(2), GPI(2), HK1(4), HK2(3), HK3(3), LDHA(1), LDHAL6B(1), LDHB(2), LDHC(1), PDHA1(5), PDHA2(4), PDHB(1), PFKL(4), PFKP(1), PGAM2(1), PGAM4(1), PGK1(2), PGM3(1), PKLR(3), TPI1(1) 44341509 97 53 96 20 36 20 8 21 12 0 0.000899 0.958 1.000 300 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 CISH(1), IL6(1), IL6R(1), JAK1(1), JAK2(4), JAK3(3), PIAS3(2), PTPRU(2), REG1A(2), STAT3(2) 11601328 19 14 19 5 4 1 2 6 6 0 0.364 0.961 1.000 301 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(1), ACTN2(6), BCAR1(3), CSK(1), CTNNA2(3), CTNNB1(3), PTK2(2), VCL(1) 14626400 20 11 20 4 9 3 2 2 4 0 0.167 0.962 1.000 302 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 9 DFFA(2), GZMB(1), HMGB2(1), TOP2A(4), TOP2B(3) 6763414 11 6 11 4 5 1 1 3 1 0 0.684 0.965 1.000 303 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(2), ENO2(1), ENO3(1), FARS2(3), GOT1(2), PAH(2), TAT(1), YARS(1) 6334074 13 6 13 3 6 3 1 1 2 0 0.294 0.970 1.000 304 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 ATF2(2), BCR(3), BLNK(2), ELK1(3), FOS(1), MAP3K1(3), MAPK1(2), MAPK3(1), MAPK8IP3(3), PAPPA(4), RAC1(1), RPS6KA1(4), RPS6KA3(3), SHC1(1), SOS1(4), VAV1(5), VAV2(2), VAV3(2) 24416270 46 25 46 11 9 8 2 15 11 1 0.143 0.970 1.000 305 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD28(1), CD3D(1), TGFB2(2), TGFB3(1), TGFBR1(2), TGFBR2(3), TGFBR3(2), TOB1(1), TOB2(1) 8037390 14 7 14 4 5 4 1 3 1 0 0.320 0.970 1.000 306 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(2), IKBKB(1), MAP3K1(3), MAP3K5(3), MAP4K5(1), MAPK8(2), NFKB1(1), NFKBIA(2), RELA(1), TNFRSF9(3), TNFSF9(2), TRAF2(2) 14757003 23 19 22 8 6 3 3 2 9 0 0.619 0.971 1.000 307 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(4), AGT(2), AGTR2(3), KNG1(2), NOS3(7), REN(2) 7529957 20 15 19 8 9 2 2 4 3 0 0.674 0.971 1.000 308 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(2), DLG4(3), EPHB2(2), F2(3), F2RL1(4), F2RL3(1), MAP2K5(2), MAPK1(2), MAPK7(5), MAPK8(2), MYEF2(3), PLD1(7), PLD3(1), PTK2(2), RAF1(1), RASAL1(4), TEC(3), VAV1(5) 20931161 52 31 51 13 16 7 6 15 8 0 0.103 0.975 1.000 309 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(5), ABCC2(1), ABCG2(1), CES1(1), CES2(2), CYP3A4(3), UGT1A1(5), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A5(2), UGT1A6(2), UGT1A7(2) 17444095 29 19 28 8 8 3 7 7 4 0 0.250 0.977 1.000 310 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(2), ELK1(3), EPO(1), EPOR(1), FOS(1), JAK2(4), MAPK3(1), MAPK8(2), PLCG1(6), RAF1(1), SHC1(1), SOS1(4), STAT5A(1), STAT5B(2) 16401154 30 20 29 8 4 7 4 9 5 1 0.205 0.977 1.000 311 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(5), AGT(2), AGTR2(3), CMA1(2), COL4A1(2), COL4A2(4), COL4A4(4), COL4A5(8), COL4A6(6), REN(2) 19182913 38 22 37 12 10 10 4 8 5 1 0.301 0.978 1.000 312 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 28 CD4(1), HLA-DRA(3), HLA-DRB1(1), IFNB1(1), IL10(1), IL12B(2), IL15(2), IL3(1), IL5(1), IL6(1), PDGFA(1), TGFB2(2), TGFB3(1), TNF(1) 10017261 19 12 19 6 4 2 4 7 2 0 0.468 0.979 1.000 313 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(3), GOT1(2), PAH(2), TAT(1), YARS(1) 6644347 9 6 9 3 3 3 1 1 1 0 0.552 0.979 1.000 314 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(2), EPHX2(2), HSD3B7(1) 3638708 5 5 5 3 2 0 0 3 0 0 0.876 0.979 1.000 315 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 CYP51A1(2), DHCR7(3), FDFT1(1), FDPS(1), HMGCS1(2), IDI1(2), LSS(1), MVD(3), NSDHL(2), SQLE(1) 10040039 18 10 18 6 6 1 3 5 3 0 0.595 0.980 1.000 316 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD28(1), CD86(1), HLA-DRA(3), HLA-DRB1(1), IFNGR2(1), IL12B(2), IL12RB1(2), IL12RB2(2), IL18(3), IL18R1(2), IL4R(2) 9657479 20 15 20 9 2 2 2 10 4 0 0.826 0.980 1.000 317 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(1), ADH1B(2), ADH6(3), ADH7(2), ADHFE1(2), AKR1A1(2), ALDH1A1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH3B2(2), ALDOA(1), ALDOB(1), DLD(1), ENO1(2), ENO2(1), ENO3(1), FBP1(1), FBP2(1), G6PC(7), GCK(2), GPI(2), HK1(4), HK2(3), HK3(3), LDHA(1), LDHB(2), LDHC(1), PDHA1(5), PDHA2(4), PDHB(1), PFKP(1), PGK1(2), PGM3(1), PKLR(3), TPI1(1) 37239647 80 46 79 19 28 19 7 17 9 0 0.0106 0.980 1.000 318 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(1), ADH1B(2), ADH6(3), ADH7(2), ADHFE1(2), AKR1A1(2), ALDH1A1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH3B2(2), ALDOA(1), ALDOB(1), DLD(1), ENO1(2), ENO2(1), ENO3(1), FBP1(1), FBP2(1), G6PC(7), GCK(2), GPI(2), HK1(4), HK2(3), HK3(3), LDHA(1), LDHB(2), LDHC(1), PDHA1(5), PDHA2(4), PDHB(1), PFKP(1), PGK1(2), PGM3(1), PKLR(3), TPI1(1) 37239647 80 46 79 19 28 19 7 17 9 0 0.0106 0.980 1.000 319 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 CISH(1), JAK1(1), JAK2(4), JAK3(3), PIAS1(1), PIAS3(2), PTPRU(2), REG1A(2), SOAT1(2) 10445505 18 13 18 9 2 1 3 6 6 0 0.867 0.980 1.000 320 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(2), FHL5(3), FSHR(2), GNAS(4), XPO1(1) 7316980 12 11 12 4 3 1 3 3 2 0 0.663 0.981 1.000 321 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(2), IFNB1(1), JAK1(1), PTPRU(2), REG1A(2), STAT1(2), STAT2(1), TYK2(7) 9519803 18 11 18 6 4 1 1 6 5 1 0.517 0.983 1.000 322 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(2), ESR2(3), PDE1A(1), PDE1B(2), PLCB1(3), PLCB2(4), PRL(1), VIP(2) 8487670 18 15 18 6 6 4 0 5 3 0 0.497 0.984 1.000 323 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 78 ABL1(4), ACTN1(1), ACTR2(2), ACTR3(1), AKT1(1), ANGPTL2(2), ARHGEF6(5), BCAR1(3), BRAF(6), CDKN2A(4), DOCK1(1), EPHB2(2), FYN(1), GRB7(4), ILK(1), ITGA1(2), ITGA10(4), ITGA11(2), ITGA2(4), ITGA4(5), ITGA5(2), ITGA6(3), ITGA7(2), ITGA8(5), MAPK1(2), MAPK10(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(3), MAPK8IP3(3), MAPK9(1), MRAS(1), MYLK(5), MYLK2(1), PAK1(2), PAK2(2), PAK3(3), PAK4(1), PAK6(3), PAK7(4), PIK3CA(50), PIK3CB(3), PKLR(3), PLCG1(6), PLCG2(9), PTEN(25), PTK2(2), RAF1(1), RALA(2), ROCK1(2), ROCK2(4), SHC1(1), SOS1(4), SOS2(5), TERF2IP(1), TLN1(5), TLN2(6), WAS(2) 93154665 233 137 208 44 45 40 41 62 45 0 1.44e-05 0.984 1.000 324 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(2), COL4A2(4), COL4A4(4), COL4A5(8), COL4A6(6), SLC23A1(1), SLC23A2(3), SLC2A1(2), SLC2A3(3) 19031248 33 20 33 10 12 7 4 6 3 1 0.151 0.984 1.000 325 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA10(3), NDUFB5(1), NDUFS1(2), NDUFV1(2), NDUFV2(1) 5303323 9 4 9 4 0 0 2 4 3 0 0.857 0.985 1.000 326 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(2), GNAS(4), PRKAR1A(2) 5040026 8 8 8 3 4 0 0 2 2 0 0.717 0.985 1.000 327 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(1), ACADM(2), ACADS(2), ACADVL(2), ACSL1(3), ACSL3(2), ACSL4(5), CPT1A(1), CPT2(1), EHHADH(1), HADHA(2), PECR(2), SCP2(1), SLC25A20(1) 12822677 26 15 26 7 2 6 2 7 9 0 0.306 0.986 1.000 328 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(3), ECHS1(2), HADHA(2), HSD17B4(2), MECR(1), PPT2(2) 6456563 12 8 12 6 2 1 2 3 4 0 0.824 0.986 1.000 329 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 EGR1(2), MAP2K2(1), MAPK1(2), MAPK3(1), NGFR(1), RAF1(1) 6275748 8 4 8 3 1 3 1 0 2 1 0.357 0.986 1.000 330 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 CISH(1), JAK1(1), JAK2(4), PTPRU(2), REG1A(2), STAT1(2) 8703704 12 6 12 6 2 1 1 3 4 1 0.733 0.987 1.000 331 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(3), ICAM1(2), ITGAL(2), ITGAM(2), ITGB2(1), SELE(6) 7911970 16 13 15 7 8 4 3 0 1 0 0.463 0.988 1.000 332 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(3), ARHGDIB(1), BIRC2(2), CASP1(4), CASP2(1), CASP4(1), CASP8(2), CYCS(2), DFFA(2), GZMB(1), LMNA(2), LMNB2(2), PRF1(3) 14726202 26 16 26 7 8 7 3 7 1 0 0.281 0.989 1.000 333 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(9), EP300(5), LPL(2), NCOA1(2), NCOA2(2), PPARG(2), RXRA(1) 14092549 23 14 22 7 6 5 1 9 2 0 0.443 0.989 1.000 334 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BAG4(1), CASP8(2), RIPK1(3), TNF(1), TNFRSF1B(2), TRADD(1), TRAF2(2) 6390003 12 11 12 5 4 3 1 1 3 0 0.638 0.990 1.000 335 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(3), BMPR1A(1), BMPR1B(1) 4799181 5 4 5 3 2 0 1 1 1 0 0.925 0.990 1.000 336 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(2), ABAT(1), ADSL(4), ADSSL1(1), AGXT(2), AGXT2(2), ASL(2), ASNS(2), ASPA(1), ASS1(3), CAD(5), CRAT(1), DARS2(2), DLD(1), GAD1(2), GAD2(1), GOT1(2), NARS(1), NARS2(1), PC(2), PDHA1(5), PDHA2(4), PDHB(1) 28831714 48 27 47 9 14 11 3 11 9 0 0.0271 0.990 1.000 337 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 BPNT1(1), CHST11(3), CHST13(2), SULT1A1(1), SULT1A2(1), SULT2A1(2), SULT2B1(2), SUOX(1) 7003860 13 9 13 6 2 1 0 7 3 0 0.840 0.990 1.000 338 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(3), FDFT1(1), FDPS(1), IDI1(2), LSS(1), MVD(3), NQO1(1), NQO2(1), SQLE(1) 8415107 14 7 14 5 4 1 3 3 3 0 0.614 0.990 1.000 339 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT2(1), ECHS1(2), EHHADH(1), GCDH(1), HADHA(2), SDS(1) 5937443 8 6 8 7 2 1 1 2 2 0 0.949 0.990 1.000 340 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(3), AMT(1), ATIC(1), ATP6V0C(1), DHFR(1), GART(4), MTHFD1(2), MTHFD1L(1), MTHFR(6), MTHFS(2), MTR(2), SHMT1(2) 13642820 26 9 26 8 6 7 5 3 4 1 0.227 0.991 1.000 341 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(2), FOS(1), IL3(1), IL3RA(2), JAK2(4), MAPK3(1), RAF1(1), SHC1(1), SOS1(4), STAT5A(1), STAT5B(2) 13498729 20 11 20 5 3 2 3 7 4 1 0.312 0.991 1.000 342 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 AKR1A1(2), ECHS1(2), EHHADH(1), HADHA(2), HSD17B4(2), SIRT1(1), SIRT5(2), SIRT7(1) 9016735 13 9 13 9 3 0 2 4 4 0 0.957 0.991 1.000 343 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 ACVR1(3), APC(2), ATF2(2), AXIN1(1), BMP10(2), BMP4(2), BMP5(4), BMPR1A(1), CHRD(1), CTNNB1(3), FZD1(2), GATA4(1), MYL2(2), RFC1(1), TGFB2(2), TGFB3(1), TGFBR1(2), TGFBR2(3), TGFBR3(2) 27739741 37 21 37 7 13 5 4 5 10 0 0.0807 0.991 1.000 344 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA2(3), ACAT2(1), ECHS1(2), EHHADH(1), HADHA(2), SDS(1) 6374315 10 8 10 9 2 1 2 2 3 0 0.970 0.992 1.000 345 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(1), CDKN1A(1), EPO(1), EPOR(1), GRIN1(2), JAK2(4), NFKB1(1), NFKBIA(2), RELA(1), SOD2(1) 9650173 15 9 15 5 4 1 1 6 3 0 0.589 0.992 1.000 346 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(2), ABAT(1), ACADS(2), ACAT2(1), ACSM1(5), AKR1B10(2), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH5A1(1), ALDH7A1(2), BDH1(1), BDH2(1), ECHS1(2), EHHADH(1), GAD1(2), GAD2(1), HADHA(2), HMGCS1(2), HMGCS2(3), HSD17B4(2), HSD3B7(1), ILVBL(5), L2HGDH(1), OXCT1(1), PDHA1(5), PDHA2(4), PDHB(1), PLA1A(3) 30882332 67 37 66 18 19 9 6 21 12 0 0.0910 0.992 1.000 347 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B4GALNT1(2), GLB1(2), HEXA(1), HEXB(1), LCT(10), SLC33A1(3), ST3GAL1(2), ST3GAL2(1), ST6GALNAC3(2), ST6GALNAC6(1), ST8SIA1(1), ST8SIA5(3) 12575808 29 18 29 9 11 1 4 5 8 0 0.581 0.993 1.000 348 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 NFKB1(1), NFKBIA(2), PLCB1(3), PRKCA(5), RELA(1) 6279992 12 9 12 7 3 0 1 6 1 1 0.889 0.993 1.000 349 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(1), CDC25B(1), CDKN1A(1), CHEK1(3), NEK1(2), WEE1(1) 5245630 9 7 9 4 4 2 2 0 1 0 0.817 0.993 1.000 350 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(6), BAIAP2(3), CASP1(4), CASP8(2), INSR(4), MAGI1(4), MAGI2(4), RERE(7), WWP1(3), WWP2(1) 18276470 38 22 38 10 13 8 3 10 4 0 0.224 0.993 1.000 351 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(2), ABAT(1), ADSL(4), AGXT(2), AGXT2(2), ASL(2), ASNS(2), ASPA(1), CAD(5), CRAT(1), GAD1(2), GAD2(1), GOT1(2), NARS(1), PC(2) 19858601 30 14 30 4 8 7 1 8 6 0 0.0284 0.993 1.000 352 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 ST3GAL1(2), ST3GAL2(1), ST3GAL4(3), ST8SIA1(1) 4304453 7 7 7 4 3 0 1 2 1 0 0.892 0.995 1.000 353 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(1), ALDH4A1(2), ALDH5A1(1), CAD(5), CPS1(3), EARS2(1), EPRS(3), GAD1(2), GAD2(1), GCLC(1), GFPT1(4), GFPT2(3), GLS(2), GLS2(1), GLUD1(4), GLUD2(1), GLUL(1), GNPNAT1(2), GOT1(2), GSS(1), NADSYN1(4), PPAT(2), QARS(3) 30078426 50 28 50 11 10 9 7 14 10 0 0.107 0.995 1.000 354 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 16 CHPF(1), CHST11(3), CHST13(2), CHST3(3), CHSY1(2), DSE(3), XYLT1(2), XYLT2(1) 10706660 17 12 17 5 6 2 1 6 2 0 0.412 0.995 1.000 355 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 FUT2(2), ST8SIA1(1) 4681304 3 2 3 4 1 0 0 1 1 0 0.996 0.996 1.000 356 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 ALDOA(1), ALDOB(1), FBP1(1), FBP2(1), FPGT(2), GCK(2), GMDS(1), GMPPA(2), HK1(4), HK2(3), HK3(3), MPI(1), PFKFB1(4), PFKFB3(2), PFKP(1), SORD(1), TPI1(1) 18222971 31 14 31 8 11 9 1 6 4 0 0.0820 0.996 1.000 357 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(1), ACACA(12), ACADL(1), ACADM(2), ACAT2(1), ALDH1A1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH6A1(4), ECHS1(2), EHHADH(1), HADHA(2), LDHA(1), LDHB(2), LDHC(1), MLYCD(3), MUT(1), PCCA(1), PCCB(3), SDS(1), SUCLG2(1) 25260109 54 26 54 14 14 14 4 13 9 0 0.128 0.996 1.000 358 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(1), ADH1B(2), ADH6(3), ADH7(2), ADHFE1(2), AGPAT2(1), AGPAT3(1), AKR1A1(2), ALDH1A1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), CEL(2), DGKA(3), DGKB(2), DGKD(3), DGKE(1), DGKG(2), DGKH(3), DGKQ(2), DGKZ(1), GK(1), GLA(2), GLB1(2), LCT(10), LIPC(1), LIPG(3), LPL(2), PNLIP(1), PNLIPRP1(4), PPAP2A(2), PPAP2C(1) 36638110 76 35 76 19 27 10 13 19 7 0 0.0325 0.996 1.000 359 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ARG2(2), ASL(2), CKM(2), CKMT1A(2), CKMT1B(2), CKMT2(1), CPS1(3), GLUD1(4), OAT(1), ODC1(3), SMS(1) 13339764 23 12 23 6 5 4 0 6 8 0 0.390 0.996 1.000 360 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CSNK1D(1), GRM1(4), PLCB1(3), PPP1CA(1), PPP2CA(4), PPP3CA(1), PRKACG(1), PRKAR1A(2) 12241106 17 10 17 6 4 2 1 9 1 0 0.717 0.996 1.000 361 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(2), CDH1(4), CREBBP(9), EP300(5), MAPK3(1), SKIL(3), TGFB2(2), TGFB3(1), TGFBR1(2), TGFBR2(3) 19594517 32 13 32 7 9 4 3 12 3 1 0.220 0.996 1.000 362 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAD(2), ALAS1(1), ALAS2(1), BLVRA(2), COX10(3), COX15(1), CP(3), EARS2(1), EPRS(3), FECH(1), FTH1(3), GUSB(3), HCCS(4), MMAB(2), PPOX(1), UGT1A1(5), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A5(2), UGT1A6(2), UGT1A7(2), UGT2A1(5), UGT2A3(6), UGT2B10(3), UGT2B11(3), UGT2B15(2), UGT2B17(2), UGT2B28(2), UGT2B4(4), UGT2B7(2), UROD(1), UROS(1) 32174527 78 50 77 20 20 10 16 30 2 0 0.0942 0.997 1.000 363 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ADCY1(2), CCNB1(2), GNAI1(4), GNAS(4), MAPK1(2), MAPK3(1), MYT1(7), PRKACG(1), PRKAR1A(2), RPS6KA1(4) 15657241 29 24 29 9 7 0 4 5 12 1 0.633 0.997 1.000 364 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 CBS(4), CTH(1), DNMT1(3), DNMT3A(11), DNMT3B(4), MARS(5), MARS2(2), MTR(2) 13252885 32 17 32 10 7 7 2 9 5 2 0.258 0.997 1.000 365 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 62 AKT1(1), BLNK(2), BTK(2), CARD11(3), CD19(1), CD22(3), CD72(3), CD79A(1), CD81(2), CR2(4), FOS(1), IFITM1(1), IKBKB(1), INPP5D(2), KRAS(3), LILRB3(2), MALT1(2), NFAT5(3), NFATC1(2), NFATC2(5), NFATC3(2), NFATC4(3), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIE(1), NRAS(4), PIK3CA(50), PIK3CB(3), PIK3CD(3), PIK3CG(5), PIK3R1(23), PIK3R2(1), PIK3R3(1), PIK3R5(1), PLCG2(9), PPP3CA(1), PPP3CC(1), RAC1(1), RAC2(1), RASGRP3(2), VAV1(5), VAV2(2), VAV3(2) 56643421 169 106 141 38 35 34 26 32 41 1 0.00369 0.997 1.000 366 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AP2A1(1), AP2M1(1), BIN1(2), CALM3(1), DNM1(1), EPN1(1), EPS15(1), PICALM(2), PPP3CA(1), PPP3CC(1), SYNJ1(6), SYNJ2(8), SYT1(1) 16393408 27 13 27 8 7 5 5 4 6 0 0.312 0.997 1.000 367 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 FUT2(2), GBGT1(1), GLA(2), HEXA(1), HEXB(1), ST3GAL1(2), ST3GAL2(1), ST3GAL4(3), ST8SIA1(1) 7707321 14 9 14 6 5 1 1 4 3 0 0.821 0.997 1.000 368 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS2(2), DHRS3(1), DHRS7(1), DHRSX(1), ESCO1(1), ESCO2(2), PNPLA3(1), SH3GLB1(3) 12645156 12 5 11 1 5 3 1 2 1 0 0.0852 0.997 1.000 369 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(4), APOBEC1(3), APOBEC3B(1), APOBEC3C(1), APOBEC3F(2), APOBEC3G(1), APOBEC4(1) 5595902 13 12 13 5 4 3 0 5 1 0 0.612 0.998 1.000 370 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP1(1), ACPP(4), ALPI(1), ALPP(5), ALPPL2(2), CYP1A2(2), CYP2A13(1), CYP2A7(1), CYP2B6(2), CYP2C18(3), CYP2C19(4), CYP2C8(2), CYP2C9(3), CYP2E1(1), CYP3A4(3), CYP3A7(1), CYP4B1(1), CYP51A1(2), PON1(2) 22281676 41 35 41 10 16 3 4 8 10 0 0.185 0.998 1.000 371 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(1), ACAA2(3), ACADM(2), ACADS(2), ACAT2(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH6A1(4), ALDH7A1(2), AOX1(5), BCAT1(1), BCKDHA(1), BCKDHB(1), DBT(2), DLD(1), ECHS1(2), EHHADH(1), HADHA(2), HIBADH(1), HIBCH(1), HMGCS1(2), HMGCS2(3), HSD17B4(2), MCCC1(3), MCCC2(5), MUT(1), OXCT1(1), PCCA(1), PCCB(3) 32766155 67 34 66 17 20 15 6 14 12 0 0.0871 0.998 1.000 372 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1A(1), ADH1B(2), ADH5(1), ADH6(3), ADH7(2), ADHFE1(2), AGK(1), AGPAT2(1), AGPAT3(1), AGPAT6(1), AKR1A1(2), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH7A1(2), CEL(2), DAK(2), DGKA(3), DGKB(2), DGKD(3), DGKE(1), DGKG(2), DGKH(3), DGKQ(2), DGKZ(1), GK(1), GK2(4), GLA(2), GLB1(2), GPAM(1), LCT(10), LIPA(2), LIPC(1), LIPG(3), LPL(2), MGLL(1), PNLIP(1), PNLIPRP1(4), PNPLA3(1), PPAP2A(2), PPAP2C(1) 44636438 91 40 91 22 33 10 16 24 8 0 0.0193 0.998 1.000 373 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 B3GALT5(1), FUT2(2), GBGT1(1), GLA(2), HEXA(1), HEXB(1), ST3GAL1(2), ST3GAL2(1), ST8SIA1(1) 8181990 12 6 12 8 4 1 1 3 3 0 0.961 0.998 1.000 374 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(2), GLS2(1), GLUD1(4), GLUD2(1) 3477988 8 7 8 4 1 2 0 4 1 0 0.840 0.998 1.000 375 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 MRPS7(2), RPL10L(1), RPL13A(1), RPL18A(1), RPL24(1), RPL29(1), RPL32(1), RPL35(2), RPL37A(1), RPL6(1), RPL7(2), RPS11(1), RPS12(1), RPS18(2), RPS2(1), RPS24(1), RPS3(3) 17172785 23 11 23 3 8 1 3 7 4 0 0.182 0.998 1.000 376 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 F13B(4), HSD17B4(2), HSD17B7(2), HSD3B1(2), HSD3B2(1) 6177440 11 11 10 6 2 3 3 2 1 0 0.758 0.998 1.000 377 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(1), ADH1B(2), ADH5(1), ADH6(3), ADH7(2), ADHFE1(2), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH7A1(2) 10101558 26 12 26 10 9 2 3 10 2 0 0.584 0.999 1.000 378 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 CD3D(1), GZMB(1), HLA-A(1), ICAM1(2), ITGAL(2), ITGB2(1), PRF1(3) 6665765 11 8 11 7 8 2 0 0 1 0 0.731 0.999 1.000 379 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(1), GPLD1(1), PGAP1(3), PIGA(3), PIGB(1), PIGC(1), PIGG(1), PIGN(1), PIGO(3), PIGQ(3), PIGS(2), PIGT(1), PIGU(1), PIGW(2), PIGX(1), PIGZ(1) 18144274 26 9 26 7 9 2 5 6 4 0 0.261 0.999 1.000 380 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(1), IARS(1), LARS(4), PDHA1(5), PDHA2(4), PDHB(1) 7640916 16 11 15 6 1 5 2 4 4 0 0.627 0.999 1.000 381 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(1), CAMK1G(1), HDAC9(1), MEF2A(2), MEF2B(1), YWHAH(1) 5870532 7 3 7 4 1 2 1 0 3 0 0.869 0.999 1.000 382 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BLNK(2), BTK(2), CALM3(1), CD79A(1), ELK1(3), FOS(1), MAP3K1(3), MAPK3(1), MAPK8(2), NFATC1(2), NFATC2(5), NFATC3(2), NFATC4(3), PLCG1(6), PPP3CA(1), PPP3CC(1), PRKCA(5), RAC1(1), RAF1(1), SHC1(1), SOS1(4), SYT1(1), VAV1(5) 29168505 54 29 53 14 14 9 5 15 9 2 0.107 0.999 1.000 383 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 HS3ST1(1), HS3ST3A1(1), XYLT1(2), XYLT2(1) 5006724 5 5 5 3 2 2 0 1 0 0 0.677 0.999 1.000 384 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 HS3ST1(1), HS3ST3A1(1), XYLT1(2), XYLT2(1) 5006724 5 5 5 3 2 2 0 1 0 0 0.677 0.999 1.000 385 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(2), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH7A1(2), CYP2C19(4), CYP2C9(3), DHRS2(2), DHRS3(1), DHRS7(1), DHRSX(1), ECHS1(2), EHHADH(1), ESCO1(1), ESCO2(2), HADHA(2), PNPLA3(1), SH3GLB1(3) 23564980 41 22 40 11 18 6 5 6 6 0 0.148 0.999 1.000 386 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(1), GABRA1(7), GABRA2(2), GABRA3(2), GABRA4(6), GABRA5(1), GABRA6(4), GPHN(1), NSF(2), UBQLN1(2) 9130343 28 19 28 10 5 8 3 7 5 0 0.551 0.999 1.000 387 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(2), CYSLTR2(1), GPR161(1), GPR171(1), GPR18(2), GPR34(2), GPR45(1), GPR75(1) 7509135 11 7 11 9 3 2 2 1 3 0 0.929 0.999 1.000 388 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(2), ALG5(3), DPAGT1(2), DPM1(2), FUT8(6), MAN1A1(2), MAN1B1(1), MGAT1(3), MGAT2(2), MGAT3(3), MGAT4A(1), MGAT5(1), RPN1(1), RPN2(1), ST6GAL1(1) 15161357 31 18 31 9 6 10 5 3 7 0 0.203 0.999 1.000 389 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(1), IL4R(2), IRS1(4), JAK1(1), JAK3(3), RPS6KB1(2), SHC1(1), STAT6(4) 11274265 18 13 18 6 3 3 1 7 4 0 0.556 0.999 1.000 390 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG1(1), ACTR2(2), ACTR3(1), AKT1(1), ANGPTL2(2), CFL1(1), CFL2(1), FLNA(13), FLNC(12), FSCN1(2), FSCN2(1), FSCN3(3), GDI1(3), GDI2(1), LIMK1(4), MYH2(16), MYLK(5), MYLK2(1), PAK1(2), PAK2(2), PAK3(3), PAK4(1), PAK6(3), PAK7(4), ROCK1(2), ROCK2(4), RPS4X(2), WASF1(1), WASL(2) 36550931 96 53 95 28 36 14 12 24 9 1 0.0597 0.999 1.000 391 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(3), CALM3(1), CRKL(1), MAP2K2(1), MAP2K3(3), MAP3K1(3), MAPK1(2), MAPK3(1), MAPK8(2), PAK1(2), PLCG1(6), PRKCA(5), PTK2B(2), RAC1(1), RAF1(1), SHC1(1), SOS1(4), SYT1(1) 21754827 40 26 39 11 9 9 6 6 8 2 0.132 0.999 1.000 392 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREB1(1), FOS(1), MAPK3(1), OPRK1(1), POLR2A(7), PRKACG(1), PRKAR1A(2) 9836712 14 11 14 5 4 1 2 5 1 1 0.561 0.999 1.000 393 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(1), IARS(1), IARS2(3), ILVBL(5), LARS(4), PDHA1(5), PDHA2(4), PDHB(1), VARS(3), VARS2(1) 14152220 28 16 27 8 4 7 2 10 5 0 0.407 0.999 1.000 394 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(2), GNAS(4), PPP2CA(4), PRKAA1(3), PRKAA2(2), PRKACG(1), PRKAG1(1), PRKAG2(1), PRKAR1A(2) 11711537 20 11 20 6 8 1 0 8 3 0 0.591 0.999 1.000 395 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B10(2), ALDOA(1), ALDOB(1), FBP1(1), FBP2(1), FPGT(2), GMDS(1), GMPPA(2), HK1(4), HK2(3), HK3(3), HSD3B7(1), MPI(1), MTMR1(4), MTMR2(3), MTMR6(1), PFKFB1(4), PFKFB2(2), PFKFB3(2), PFKL(4), PFKP(1), PGM2(4), SORD(1), TPI1(1), TSTA3(1) 28312461 51 24 51 13 18 10 4 11 8 0 0.0792 1.000 1.000 396 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 ARHGDIB(1), BAG4(1), CASP2(1), CASP8(2), CRADD(1), DFFA(2), LMNA(2), LMNB2(2), MADD(2), MAP3K1(3), MAPK8(2), PAK1(2), PAK2(2), PRKDC(11), RB1(6), RIPK1(3), SPTAN1(5), TNF(1), TRADD(1), TRAF2(2) 29449092 52 37 52 12 13 10 8 9 11 1 0.123 1.000 1.000 397 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(3), F2R(2), F2RL3(1), GNAI1(4), ITGA1(2), ITGB1(2), MAPK1(2), MAPK3(1), PLA2G4A(4), PLCB1(3), PRKCA(5), PTGS1(2), PTK2(2), RAF1(1), TBXAS1(1) 18595668 35 25 35 10 5 1 9 13 5 2 0.352 1.000 1.000 398 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GSS(1), NFKB1(1), NOX1(1), RELA(1), TNF(1), XDH(8) 7555417 13 6 13 7 3 4 0 5 1 0 0.782 1.000 1.000 399 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(2), ADRB2(1), GNAS(4), PLCE1(8), PRKACG(1), PRKAR1A(2), RAP2B(2) 11278800 20 15 20 7 9 4 1 3 3 0 0.540 1.000 1.000 400 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(2), ALOX15(2), ALOX5(1), CYP1A2(2), CYP2C18(3), CYP2C19(4), CYP2C8(2), CYP2C9(3), CYP2E1(1), CYP3A4(3), CYP3A7(1), HSD3B7(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(4), PLA2G4A(4), PLA2G5(1), PLA2G6(2) 18196334 38 30 38 11 12 5 5 8 8 0 0.290 1.000 1.000 401 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(3), CAPNS1(1), CAPNS2(1), CSNK1A1(2), CSNK1D(1), PPP2CA(4) 7056883 12 4 12 5 3 1 3 4 1 0 0.746 1.000 1.000 402 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(1), FOSL2(1), IFNAR1(2), IFNAR2(1), IFNB1(1), MAPK8(2), NFKB1(1), RELA(1), TNFRSF11A(2) 8449322 12 7 12 8 1 3 2 5 1 0 0.920 1.000 1.000 403 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 14 CD4(1), EPO(1), IL3(1), IL5(1), IL6(1), IL9(1) 4546118 6 4 6 5 1 0 0 4 1 0 0.961 1.000 1.000 404 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(3), AMT(1), ATIC(1), DHFR(1), FTCD(4), GART(4), MTFMT(1), MTHFD1(2), MTHFD1L(1), MTHFR(6), MTHFS(2), MTR(2), SHMT1(2) 14430898 30 13 30 10 8 7 5 4 5 1 0.303 1.000 1.000 405 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(2), ACAD9(1), ADH1A(1), ADH1B(2), ADH5(1), ADH6(3), ADH7(2), ADHFE1(2), DHRS2(2), DHRS3(1), DHRS7(1), DHRSX(1), ESCO1(1), ESCO2(2), PNPLA3(1), SH3GLB1(3) 19045120 26 11 25 9 6 5 2 12 1 0 0.607 1.000 1.000 406 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(2), ADRB2(1), CFTR(4), GNAS(4), PRKACG(1), PRKAR1A(2), SLC9A3R1(1) 9985321 15 13 15 5 7 2 1 3 2 0 0.550 1.000 1.000 407 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 CES1(1) 4606534 1 1 1 1 0 1 0 0 0 0 0.829 1.000 1.000 408 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAX(1), CASP8(2), CYCS(2), MAP3K1(3), MAPK1(2), MAPK3(1), MAPK8(2), NFKB1(1), NSMAF(1), RAF1(1), RELA(1), RIPK1(3), SMPD1(1), TRADD(1), TRAF2(2) 15647175 24 17 24 9 6 5 4 3 5 1 0.473 1.000 1.000 409 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 CBS(4), CTH(1), DNMT1(3), DNMT3A(11), DNMT3B(4), MARS(5), MARS2(2), MTFMT(1), MTR(2), SRM(2), TAT(1) 15780562 36 19 36 12 8 7 3 11 5 2 0.326 1.000 1.000 410 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 FOS(1), MAPK1(2), MAPK3(1), NFKB1(1), NFKBIA(2), PLCB1(3), PRKCA(5), RAF1(1), RELA(1), TNF(1) 11846307 18 13 18 9 3 2 2 6 3 2 0.708 1.000 1.000 411 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(2), POLR2A(7), POLR2B(3), POLR2C(2), POLR2G(1), POLRMT(1) 10310202 16 11 16 6 5 2 2 6 1 0 0.626 1.000 1.000 412 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(2), ABAT(1), ACADS(2), ACAT2(1), ALDH1A1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH5A1(1), ECHS1(2), EHHADH(1), GAD1(2), GAD2(1), HADHA(2), L2HGDH(1), OXCT1(1), PDHA1(5), PDHA2(4), PDHB(1), SDS(1) 19672597 42 26 41 14 13 7 4 9 9 0 0.233 1.000 1.000 413 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(1), CD28(1), CD3D(1), CSK(1), CTLA4(1), DAG1(1), EPHB2(2), FBXW7(4), GRAP2(1), ITK(1), LAT(2), LCK(1), LCP2(1), MAPK1(2), NCK1(2), NFAT5(3), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIE(1), PAK1(2), PAK2(2), PAK3(3), PAK4(1), PAK6(3), PAK7(4), PLCG1(6), PTPRC(7), RAF1(1), RASGRP1(1), RASGRP2(2), RASGRP3(2), RASGRP4(2), SOS1(4), SOS2(5), VAV1(5), ZAP70(5) 42431766 85 48 84 20 24 17 8 21 15 0 0.0375 1.000 1.000 414 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM3(1), CXCR4(2), FOS(1), MAPK8(2), PLCG1(6), PRKCA(5), PTK2B(2), SYT1(1) 10519687 20 18 19 9 3 6 5 4 1 1 0.570 1.000 1.000 415 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG10B(2), ALG12(2), ALG13(4), ALG14(1), ALG3(2), ALG5(3), ALG6(3), DAD1(1), DHDDS(1), DPAGT1(2), DPM1(2), FUT8(6), GANAB(4), MAN1A1(2), MAN1A2(1), MAN1B1(1), MAN1C1(2), MAN2A1(4), MGAT1(3), MGAT2(2), MGAT3(3), MGAT4A(1), MGAT5(1), MGAT5B(1), RPN1(1), RPN2(1), ST6GAL1(1), STT3B(2) 32247634 59 32 59 15 12 16 9 8 14 0 0.109 1.000 1.000 416 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOA(1), ALDOB(1), FBP1(1), FBP2(1), GOT1(2), ME1(1), ME2(1), ME3(1), PGK1(2), PKLR(3), RPIA(1), TKT(2), TPI1(1) 13758488 18 11 18 6 5 4 1 5 3 0 0.497 1.000 1.000 417 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(2), EPRS(3), FARS2(3), GARS(3), HARS(2), IARS(1), LARS(4), MARS(5), MARS2(2), NARS(1), QARS(3), RARS(2), SARS(1), WARS2(2), YARS(1) 24437873 35 17 35 9 5 10 3 11 6 0 0.328 1.000 1.000 418 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(3), GLI2(2), GLI3(5), PRKACG(1), PRKAR1A(2), SHH(1), SMO(2), SUFU(3) 12703482 19 12 19 9 5 5 2 4 3 0 0.710 1.000 1.000 419 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 92 AKT1(1), CARD11(3), CBL(1), CBLB(2), CBLC(2), CD28(1), CD3D(1), CD4(1), CD40LG(2), CDK4(1), CTLA4(1), FOS(1), FYN(1), GRAP2(1), ICOS(1), IKBKB(1), IL10(1), IL5(1), ITK(1), KRAS(3), LAT(2), LCK(1), LCP2(1), MALT1(2), MAP3K8(4), NCK1(2), NFAT5(3), NFATC1(2), NFATC2(5), NFATC3(2), NFATC4(3), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIE(1), NRAS(4), PAK1(2), PAK2(2), PAK3(3), PAK4(1), PAK6(3), PAK7(4), PDK1(2), PIK3CA(50), PIK3CB(3), PIK3CD(3), PIK3CG(5), PIK3R1(23), PIK3R2(1), PIK3R3(1), PIK3R5(1), PLCG1(6), PPP3CA(1), PPP3CC(1), PRKCQ(2), PTPRC(7), RASGRP1(1), SOS1(4), SOS2(5), TEC(3), TNF(1), VAV1(5), VAV2(2), VAV3(2), ZAP70(5) 77333559 212 125 183 45 39 41 37 46 47 2 0.00102 1.000 1.000 420 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(2), IL10(1), IL10RB(1), IL6(1), JAK1(1), STAT1(2), STAT3(2), STAT5A(1), TNF(1) 9265383 12 7 12 6 3 1 2 5 0 1 0.784 1.000 1.000 421 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 64 ACHE(2), AGPAT2(1), AGPAT3(1), AGPAT6(1), CDS2(2), CHAT(4), CHKB(1), DGKA(3), DGKB(2), DGKD(3), DGKE(1), DGKG(2), DGKH(3), DGKQ(2), DGKZ(1), ESCO1(1), ESCO2(2), ETNK1(1), ETNK2(2), GNPAT(1), GPAM(1), LYPLA1(1), PCYT1B(1), PHOSPHO1(1), PISD(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(4), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLD1(7), PNPLA3(1), PPAP2A(2), PPAP2C(1), PTDSS1(2), SH3GLB1(3) 49859830 70 32 70 15 22 18 8 13 9 0 0.00940 1.000 1.000 422 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ADH1A(1), ADH1B(2), ADH6(3), ADH7(2), ADHFE1(2), ALDH1A3(4), ALDH3A1(4), ALDH3B2(2), AOX1(5), DBH(3), DDC(2), FAH(2), GOT1(2), GSTZ1(3), HGD(5), HPD(1), MAOA(2), TAT(1), TH(3), TPO(6), TYR(4) 24148464 59 32 59 20 21 7 6 19 6 0 0.280 1.000 1.000 423 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(6), CALM3(1), CAPNS1(1), CAPNS2(1), EP300(5), HDAC2(4), NFATC1(2), NFATC2(5), PPP3CA(1), PPP3CC(1), PRKCA(5), SYT1(1) 18592690 33 17 33 11 9 4 5 8 6 1 0.461 1.000 1.000 424 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 14 EPO(1), FLT3(4), IGF1(1), IL3(1), IL6(1), IL9(1), KITLG(2), TGFB2(2), TGFB3(1) 6198671 14 7 14 6 3 1 3 5 2 0 0.728 1.000 1.000 425 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 MAPK8(2), NFKB1(1), RELA(1), TNFRSF13B(1), TNFRSF17(1), TNFSF13B(1), TRAF2(2), TRAF3(1), TRAF5(3) 11076415 13 8 13 7 5 4 2 1 1 0 0.789 1.000 1.000 426 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CD3D(1), ETV5(2), IL12B(2), IL12RB1(2), IL12RB2(2), IL18(3), IL18R1(2), JAK2(4), MAPK8(2), STAT4(2), TYK2(7) 14234081 29 15 29 10 8 3 6 10 2 0 0.543 1.000 1.000 427 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 DUSP1(1), IKBKAP(1), IKBKB(1), MAP3K1(3), NFKB1(1), NFKBIA(2), RELA(1), TNFAIP3(2), TRAF3(1) 13825823 13 9 13 9 7 1 1 2 2 0 0.909 1.000 1.000 428 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA2(3), ACADL(1), ACADM(2), ACADS(2), ACAT2(1), ALDH1A1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH6A1(4), AOX1(5), BCAT1(1), BCKDHA(1), BCKDHB(1), ECHS1(2), EHHADH(1), HADHA(2), HIBADH(1), MCCC1(3), MCCC2(5), MUT(1), OXCT1(1), PCCA(1), PCCB(3), SDS(1) 27454596 56 29 55 18 15 16 5 11 9 0 0.249 1.000 1.000 429 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(3), ICAM1(2), ITGA4(5), ITGAL(2), ITGAM(2), ITGB1(2), ITGB2(1), SELE(6), SELP(2) 12153975 25 19 24 10 9 4 7 3 2 0 0.496 1.000 1.000 430 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(12), ACACB(11), FASN(3), MCAT(2), OXSM(2) 12024579 30 21 30 11 8 5 4 7 6 0 0.451 1.000 1.000 431 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH3B2(2), ALDH7A1(2), AMDHD1(2), ASPA(1), CNDP1(2), DDC(2), FTCD(4), HAL(1), HARS(2), HARS2(1), HDC(2), HNMT(1), LCMT1(2), LCMT2(1), MAOA(2), METTL2B(3), METTL6(1), PRMT2(2), PRMT5(4), PRMT6(1), PRMT7(1), PRMT8(4), PRPS1(1), PRPS2(3), UROC1(1), WBSCR22(2) 30196195 63 34 63 20 24 9 9 14 7 0 0.189 1.000 1.000 432 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTN1(1), ACTN2(6), CAPNS1(1), CAPNS2(1), ITGA1(2), ITGB1(2), ITGB3(2), PTK2(2), RAC1(1), SPTAN1(5), TLN1(5) 21754738 28 12 28 8 9 3 6 6 4 0 0.322 1.000 1.000 433 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ADH1A(1), ADH1B(2), ADH5(1), ADH6(3), ADH7(2), ADHFE1(2), ALDH1A3(4), ALDH3A1(4), ALDH3B2(2), AOX1(5), DBH(3), DDC(2), ECH1(1), ESCO1(1), ESCO2(2), FAH(2), GOT1(2), GSTZ1(3), HGD(5), HPD(1), LCMT1(2), LCMT2(1), MAOA(2), METTL2B(3), METTL6(1), PNPLA3(1), PRMT2(2), PRMT5(4), PRMT6(1), PRMT7(1), PRMT8(4), SH3GLB1(3), TAT(1), TH(3), TPO(6), TYR(4), TYRP1(4), WBSCR22(2) 45304110 93 44 92 27 26 14 12 28 13 0 0.116 1.000 1.000 434 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 73 CALM3(1), CALML3(1), CALML6(1), CDS2(2), DGKA(3), DGKB(2), DGKD(3), DGKE(1), DGKG(2), DGKH(3), DGKQ(2), DGKZ(1), INPP4A(1), INPP4B(4), INPP5B(3), INPP5D(2), INPPL1(5), ITPK1(3), ITPR1(4), ITPR2(12), ITPR3(13), OCRL(5), PI4KA(7), PI4KB(2), PIK3C2A(4), PIK3C2B(2), PIK3C2G(1), PIK3C3(2), PIK3CA(50), PIK3CB(3), PIK3CD(3), PIK3CG(5), PIK3R1(23), PIK3R2(1), PIK3R3(1), PIK3R5(1), PIP4K2A(1), PIP4K2B(1), PIP4K2C(2), PIP5K1B(1), PIP5K1C(1), PLCB1(3), PLCB2(4), PLCB3(4), PLCB4(3), PLCD1(1), PLCD3(2), PLCE1(8), PLCG1(6), PLCG2(9), PLCZ1(4), PRKCA(5), PRKCG(2), PTEN(25), PTPMT1(1), SYNJ1(6), SYNJ2(8) 94940119 276 159 246 60 57 51 46 59 60 3 0.000274 1.000 1.000 435 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARF1(1), ARFGEF2(3), CLTA(1), COPA(2), GBF1(4), GPLD1(1), KDELR1(1), KDELR2(1), KDELR3(1) 12375308 15 9 15 6 3 4 3 2 3 0 0.602 1.000 1.000 436 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 ATF2(2), CREB1(1), DAXX(2), DDIT3(1), ELK1(3), MAP3K1(3), MAP3K5(3), MAP3K9(3), MAPKAPK2(1), MAPKAPK5(2), MAX(4), MEF2A(2), MEF2B(1), MKNK1(2), PLA2G4A(4), RAC1(1), RIPK1(3), RPS6KA5(1), SHC1(1), STAT1(2), TGFB2(2), TGFB3(1), TGFBR1(2), TRADD(1), TRAF2(2) 27928825 50 31 48 14 14 7 8 11 9 1 0.264 1.000 1.000 437 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 CREB1(1), PTK2B(2), SHC1(1), SOS1(4) 6731930 8 6 8 4 1 2 0 3 2 0 0.730 1.000 1.000 438 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 CES1(1), ESCO1(1), ESCO2(2), LIPA(2), PLA1A(3), PNPLA3(1), SH3GLB1(3) 19324133 13 4 13 3 2 4 1 4 2 0 0.342 1.000 1.000 439 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 CREBBP(9), CTBP1(5), CTBP2(1), DLL3(1), DTX1(4), DTX3L(1), DTX4(2), DVL2(1), DVL3(2), EP300(5), HDAC2(4), JAG1(4), JAG2(1), LFNG(2), MAML1(4), MAML2(2), MAML3(4), MFNG(1), NCOR2(7), NCSTN(4), NOTCH1(52), NOTCH2(11), NOTCH3(6), NOTCH4(8), NUMB(1), NUMBL(2), RBPJ(7), RBPJL(2), SNW1(2) 52698109 155 96 142 39 34 21 12 30 54 4 0.145 1.000 1.000 440 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(2), AGTR2(3), CALM3(1), CAMK2A(2), CAMK2D(1), CAMK2G(2), F2(3), FYN(1), GNA11(1), GNAI1(4), JAK2(4), MAP2K2(1), MAPK1(2), MAPK3(1), MAPK8(2), MYLK(5), PLCG1(6), PRKCA(5), PTK2B(2), RAF1(1), SHC1(1), SOS1(4), STAT1(2), STAT3(2), STAT5A(1), SYT1(1) 31773570 60 35 59 18 15 8 12 14 8 3 0.175 1.000 1.000 441 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOA(1), ALDOB(1), FBP1(1), FBP2(1), GOT1(2), ME1(1), ME3(1), PGK1(2), PKLR(3), RPIA(1), TKT(2), TKTL2(2), TPI1(1) 15384007 19 12 19 8 5 4 1 5 4 0 0.711 1.000 1.000 442 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(1), ACADM(2), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH7A1(2), CNDP1(2), DPYD(4), DPYS(4), ECHS1(2), EHHADH(1), GAD1(2), GAD2(1), HADHA(2), HIBCH(1), MLYCD(3), SMS(1), SRM(2) 20575775 43 19 42 15 14 6 4 11 8 0 0.415 1.000 1.000 443 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 CLOCK(1), CRY1(2), CSNK1D(1), CSNK1E(1), NPAS2(1), NR1D1(1), PER1(5), PER2(3), PER3(1) 13016512 16 6 16 8 2 4 1 8 1 0 0.877 1.000 1.000 444 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 126 ARAF(1), BRAF(6), CD244(1), FAS(1), FASLG(1), FCGR3A(1), FYN(1), GZMB(1), HLA-A(1), HLA-C(1), HLA-E(1), ICAM1(2), ICAM2(1), IFNA21(4), IFNA5(1), IFNA6(1), IFNA7(1), IFNA8(1), IFNAR1(2), IFNAR2(1), IFNB1(1), IFNGR2(1), ITGAL(2), ITGB2(1), KIR2DL3(2), KIR3DL1(1), KLRC1(2), KLRC2(1), KRAS(3), LAT(2), LCK(1), LCP2(1), MAP2K2(1), MAPK1(2), MAPK3(1), MICA(4), MICB(1), NCR1(1), NFAT5(3), NFATC1(2), NFATC2(5), NFATC3(2), NFATC4(3), NRAS(4), PAK1(2), PIK3CA(50), PIK3CB(3), PIK3CD(3), PIK3CG(5), PIK3R1(23), PIK3R2(1), PIK3R3(1), PIK3R5(1), PLCG1(6), PLCG2(9), PPP3CA(1), PPP3CC(1), PRF1(3), PRKCA(5), PRKCG(2), PTK2B(2), PTPN11(7), RAC1(1), RAC2(1), RAF1(1), SH2D1A(2), SH2D1B(1), SH3BP2(1), SHC1(1), SHC2(1), SHC3(1), SHC4(1), SOS1(4), SOS2(5), TNF(1), TNFRSF10C(1), TNFRSF10D(1), ULBP1(1), ULBP3(4), VAV1(5), VAV2(2), VAV3(2), ZAP70(5) 86455370 244 153 212 58 43 40 42 61 55 3 0.00211 1.000 1.000 445 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 AKT1(1), APC(2), ASAH1(1), DAG1(1), DLG4(3), EPHB2(2), GNAI1(4), ITPR1(4), ITPR2(12), ITPR3(13), KCNJ3(1), KCNJ5(3), KCNJ9(1), MAPK1(2), PITX2(4), PTX3(2), RAC1(1), RYR1(11) 34848750 68 38 68 21 17 8 17 16 9 1 0.237 1.000 1.000 446 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(2), CALM3(1), CREB1(1), ELK1(3), FOS(1), GNAI1(4), GNAS(4), MAPK3(1), NFATC1(2), NFATC2(5), NFATC3(2), NFATC4(3), PLCG1(6), PPP3CA(1), PPP3CC(1), PRKACG(1), PRKAR1A(2), PRKCA(5), RAF1(1), RPS6KA3(3), SYT1(1) 26677921 50 34 49 16 13 5 7 13 10 2 0.348 1.000 1.000 447 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1D1(1), ARSD(3), ARSE(3), CYP11B1(1), CYP11B2(1), HSD17B7(2), HSD17B8(1), HSD3B1(2), HSD3B2(1), LCMT1(2), LCMT2(1), METTL2B(3), METTL6(1), PRMT2(2), PRMT5(4), PRMT6(1), PRMT7(1), PRMT8(4), SRD5A1(1), SULT2A1(2), SULT2B1(2), UGT1A1(5), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A5(2), UGT1A6(2), UGT1A7(2), UGT2A1(5), UGT2A3(6), UGT2B10(3), UGT2B11(3), UGT2B15(2), UGT2B17(2), UGT2B28(2), UGT2B4(4), UGT2B7(2), WBSCR22(2) 38270867 86 55 84 28 21 11 18 28 8 0 0.231 1.000 1.000 448 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM3(1), DLG4(3), GRIN1(2), GRIN2A(7), GRIN2B(6), GRIN2C(4), GRIN2D(4), NOS1(5), PPP3CA(1), PPP3CC(1), PRKACG(1), PRKAR1A(2), PRKCA(5), SYT1(1) 19464413 43 34 43 16 17 6 6 9 4 1 0.386 1.000 1.000 449 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT2(1), ACOT11(2), DHRS2(2), DHRS3(1), DHRS7(1), DHRSX(1), ECHS1(2), EHHADH(1), ESCO1(1), ESCO2(2), GCDH(1), HADHA(2), PNPLA3(1), SH3GLB1(3) 19795829 21 10 20 8 7 4 3 4 3 0 0.556 1.000 1.000 450 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(2), ASAH1(1), CREB1(1), DAG1(1), EPHB2(2), FOS(1), MAPK1(2), MAPK10(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(3), MAPK8IP3(3), MAPK9(1) 21844628 21 13 21 7 4 4 5 4 4 0 0.383 1.000 1.000 451 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CALM3(1), EGR3(1), MAP3K1(3), NFATC1(2), NFATC2(5), NFKB1(1), NFKBIA(2), PLCG1(6), PPP3CA(1), PPP3CC(1), PRKACG(1), PRKAR1A(2), RELA(1), SYT1(1), VIP(2), VIPR2(1) 21363306 31 22 30 11 7 4 2 13 5 0 0.588 1.000 1.000 452 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(13), C5(6), C6(3), C7(5), ICAM1(2), IL6(1), ITGA4(5), ITGAL(2), ITGB1(2), ITGB2(1), SELP(2), SELPLG(1), TNF(1), VCAM1(1) 18896072 45 29 45 18 14 6 7 11 7 0 0.479 1.000 1.000 453 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1QA(2), C1QB(1), C1R(2), C1S(2), C2(5), C3(13), C5(6), C6(3), C7(5), C8A(2), MASP1(2), MBL2(3) 16182545 46 25 46 17 18 4 4 13 7 0 0.518 1.000 1.000 454 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 APAF1(3), CYCS(2), DAXX(2), FAS(1), FASLG(1), MAPKAPK2(1), MAPKAPK3(1), TNF(1) 8644454 12 6 12 5 0 3 3 5 1 0 0.772 1.000 1.000 455 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ALDH1A3(4), ALDH3A1(4), ALDH3B2(2), DDC(2), EPX(5), GOT1(2), HPD(1), LPO(5), MAOA(2), MPO(2), PRDX1(1), TAT(1), TPO(6) 16747382 37 21 37 13 16 8 4 6 2 1 0.227 1.000 1.000 456 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2A1L(1), GTF2A2(1), GTF2E1(3), GTF2F1(1), GTF2H1(1), GTF2H4(1), GTF2IRD1(3), STON1(2), TAF1(8), TAF10(1), TAF1L(4), TAF2(3), TAF4(3), TAF4B(3), TAF5L(2), TAF6L(1), TAF7L(2), TAF9(2), TAF9B(1), TBPL1(1), TBPL2(1) 27486416 45 22 45 13 9 8 6 14 7 1 0.295 1.000 1.000 457 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CALM3(1), CAMK1(1), CAMK1G(1), CAMK2A(2), CAMK2D(1), CAMK2G(2), CAMK4(2), ESRRA(2), HDAC5(1), MEF2A(2), MEF2B(1), PPARA(3), PPP3CA(1), PPP3CC(1), SLC2A4(1), SYT1(1), YWHAH(1) 15426037 24 9 24 9 6 7 3 2 6 0 0.472 1.000 1.000 458 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 AKR1C3(1), ALOX12(1), ALOX12B(2), ALOX15(2), ALOX5(1), CBR3(1), CYP2B6(2), CYP2C18(3), CYP2C19(4), CYP2C8(2), CYP2C9(3), CYP2E1(1), CYP2U1(1), CYP4A11(1), CYP4A22(2), CYP4F3(4), DHRS4(1), EPHX2(2), GGT1(2), GPX2(2), GPX6(1), LTA4H(4), PLA2G12B(1), PLA2G2D(1), PLA2G3(4), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PTGES(1), PTGES2(1), PTGS1(2), PTGS2(2), TBXAS1(1) 29656133 63 46 63 20 17 10 8 14 14 0 0.268 1.000 1.000 459 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOA(1), ALDOB(1), DERA(1), FBP1(1), FBP2(1), G6PD(2), GPI(2), H6PD(3), PFKL(4), PFKP(1), PGD(1), PGM3(1), PRPS1(1), PRPS1L1(1), PRPS2(3), RBKS(1), RPIA(1), TALDO1(2), TKT(2), TKTL2(2) 18523774 32 20 32 12 13 7 0 4 8 0 0.354 1.000 1.000 460 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 AGA(1), FUCA1(2), FUCA2(3), GLB1(2), GUSB(3), HEXA(1), HEXB(1), HGSNAT(2), HPSE(2), HPSE2(3), HYAL1(3), HYAL2(1), IDS(2), LCT(10), MAN2B1(2), MAN2B2(5), MAN2C1(2), MANBA(1), NAGLU(3), NEU1(1), NEU2(5), NEU3(2), SPAM1(3) 26265325 60 40 60 20 22 5 9 15 9 0 0.401 1.000 1.000 461 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 98 AKT1(1), CASP8(2), CCL5(1), CD14(1), CD40(1), CD86(1), CXCL9(1), FOS(1), IFNA21(4), IFNA5(1), IFNA6(1), IFNA7(1), IFNA8(1), IFNAR1(2), IFNAR2(1), IFNB1(1), IKBKB(1), IKBKE(5), IL12B(2), IL1B(2), IL6(1), IRAK1(1), IRAK4(2), IRF3(1), IRF5(1), IRF7(3), LBP(2), MAP2K2(1), MAP2K3(3), MAP3K8(4), MAPK1(2), MAPK10(1), MAPK12(2), MAPK13(1), MAPK3(1), MAPK8(2), MAPK9(1), NFKB1(1), NFKB2(1), NFKBIA(2), PIK3CA(50), PIK3CB(3), PIK3CD(3), PIK3CG(5), PIK3R1(23), PIK3R2(1), PIK3R3(1), PIK3R5(1), RAC1(1), RELA(1), RIPK1(3), SPP1(2), STAT1(2), TBK1(2), TICAM1(1), TLR1(4), TLR2(1), TLR3(5), TLR4(2), TLR5(2), TLR6(3), TLR7(6), TLR9(3), TNF(1), TOLLIP(1), TRAF3(1) 68432583 192 126 164 48 33 36 39 40 41 3 0.00780 1.000 1.000 462 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ALDH1A3(4), ALDH3A1(4), ALDH3B2(2), DDC(2), EPX(5), ESCO1(1), ESCO2(2), GOT1(2), HPD(1), LPO(5), MAOA(2), MPO(2), PNPLA3(1), SH3GLB1(3), TAT(1), TPO(6) 26102042 43 23 43 14 17 11 4 8 3 0 0.209 1.000 1.000 463 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(7), ATP4A(5), ATP4B(2), ATP5B(2), ATP5G2(1), ATP6AP1(2), ATP6V0A2(1), ATP6V0C(1), ATP6V0D2(2), ATP6V1A(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1E2(2), ATP6V1G3(2), ATP6V1H(1), COX10(3), COX15(1), COX17(1), COX6B1(1), COX7A1(1), COX7B(3), COX7B2(1), NDUFA10(3), NDUFA3(1), NDUFA7(1), NDUFA9(3), NDUFB11(1), NDUFB5(1), NDUFS1(2), NDUFS3(1), NDUFS8(1), NDUFV1(2), NDUFV2(1), SDHA(4), SDHC(2), TCIRG1(2), UQCRC1(3), UQCRC2(1), UQCRH(2) 42441395 75 39 73 22 15 12 13 21 13 1 0.207 1.000 1.000 464 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 ATM(8), BMPR1B(1), CDK4(1), CDKN1B(3), CEBPB(1), DMC1(2), EGR1(2), ESR2(3), FSHR(2), GJA4(1), MLH1(4), MSH5(2), NCOR1(8), NR5A1(1), NRIP1(2), PGR(4), PRLR(2), SMPD1(1), VDR(2), ZP2(4) 26759652 54 29 54 18 10 10 7 14 12 1 0.618 1.000 1.000 465 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 ANKHD1(3), EEF1A2(1), EEF1B2(1), EEF1D(3), EEF2(1), EEF2K(2), EIF1AX(4), EIF2AK1(1), EIF2AK3(2), EIF2B4(1), EIF2S2(1), EIF4A1(6), EIF4A2(2), EIF4E(2), EIF4G1(4), EIF4G3(6), EIF5A(1), GSPT2(4), PABPC1(4), PABPC3(1), PAIP1(1), SLC35A4(1) 33477557 52 33 51 16 12 7 5 18 10 0 0.467 1.000 1.000 466 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 CALR(2), CANX(1), CD4(1), CIITA(1), CREB1(1), CTSB(3), HLA-A(1), HLA-C(1), HLA-DMA(2), HLA-DMB(4), HLA-DOA(1), HLA-DPB1(1), HLA-DQA1(1), HLA-DQA2(2), HLA-DRA(3), HLA-DRB1(1), HLA-DRB5(1), HLA-E(1), HLA-F(1), HSP90AA1(1), HSP90AB1(1), IFI30(1), IFNA21(4), IFNA5(1), IFNA6(1), IFNA7(1), IFNA8(1), KIR2DL3(2), KIR3DL1(1), KIR3DL3(1), KLRC1(2), KLRC2(1), KLRC4(1), LGMN(1), NFYA(1), PSME1(3), RFX5(1), RFXANK(1), TAP1(1) 35248753 56 32 56 19 8 9 9 19 11 0 0.408 1.000 1.000 467 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 75 ACP1(1), ACTB(2), ACTG1(1), ACTN1(1), ACTN2(6), ACTN4(2), ACVR1B(3), ACVR1C(1), BAIAP2(3), CDH1(4), CREBBP(9), CSNK2A1(2), CSNK2B(1), CTNNA2(3), CTNNA3(3), CTNNB1(3), CTNND1(1), EGFR(45), EP300(5), ERBB2(2), FARP2(2), FER(1), FGFR1(2), FYN(1), IGF1R(7), INSR(4), IQGAP1(9), LEF1(1), LMO7(6), MAPK1(2), MAPK3(1), MET(10), MLLT4(7), NLK(1), PARD3(2), PTPN1(1), PTPRB(6), PTPRF(5), PTPRJ(4), PTPRM(7), PVRL1(1), PVRL3(2), PVRL4(1), RAC1(1), RAC2(1), SMAD2(3), SMAD3(3), SORBS1(1), SSX2IP(1), TCF7L2(4), TGFBR1(2), TGFBR2(3), TJP1(5), VCL(1), WAS(2), WASF1(1), WASF2(1), WASF3(3), WASL(2), YES1(2) 91303223 217 117 200 47 61 33 24 63 35 1 0.000168 1.000 1.000 468 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 150 AKT1(1), CBL(1), CBLB(2), CBLC(2), CCND1(4), CISH(1), CLCF1(1), CNTF(1), CNTFR(2), CREBBP(9), CRLF2(3), CSF2RA(7), CSF2RB(2), CSF3R(2), EP300(5), EPO(1), EPOR(1), GH1(1), GH2(2), GHR(4), IFNA21(4), IFNA5(1), IFNA6(1), IFNA7(1), IFNA8(1), IFNAR1(2), IFNAR2(1), IFNB1(1), IFNGR2(1), IFNK(1), IFNW1(2), IL10(1), IL10RB(1), IL12B(2), IL12RB1(2), IL12RB2(2), IL13RA1(3), IL15(2), IL19(1), IL20RA(2), IL21R(1), IL22RA1(1), IL23A(1), IL23R(5), IL26(1), IL2RB(2), IL3(1), IL3RA(2), IL4R(2), IL5(1), IL5RA(2), IL6(1), IL6R(1), IL6ST(3), IL7R(1), IL9(1), IL9R(2), IRF9(3), JAK1(1), JAK2(4), JAK3(3), LEPR(2), LIFR(2), MPL(2), OSMR(3), PIAS1(1), PIAS3(2), PIAS4(2), PIK3CA(50), PIK3CB(3), PIK3CD(3), PIK3CG(5), PIK3R1(23), PIK3R2(1), PIK3R3(1), PIK3R5(1), PIM1(2), PRL(1), PRLR(2), PTPN11(7), SOCS4(2), SOCS5(2), SOS1(4), SOS2(5), SPRED1(1), SPRED2(3), SPRY1(1), SPRY2(3), SPRY3(1), SPRY4(3), STAM(2), STAM2(1), STAT1(2), STAT2(1), STAT3(2), STAT4(2), STAT5A(1), STAT5B(2), STAT6(4), TPO(6), TYK2(7) 110713110 291 156 262 66 52 45 56 83 53 2 0.000744 1.000 1.000 469 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH7A1(2), ARG2(2), ASL(2), ASS1(3), CPS1(3), MAOA(2), ODC1(3), SMS(1), SRM(2) 22447678 33 18 33 12 12 4 2 7 8 0 0.574 1.000 1.000 470 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 CEBPB(1), CLOCK(1), CRY1(2), DNAJA1(3), EIF4G2(1), ETV6(4), HERPUD1(1), HSPA8(3), IDI1(2), KLF9(2), MYF6(2), NCKAP1(4), NCOA4(3), NR1D2(1), PER1(5), PER2(3), PPP1R3C(1), PPP2CB(1), PSMA4(1), PURA(1), SF3A3(1), TOB1(1), UGP2(1), ZFR(1) 27915352 46 22 46 15 7 9 7 19 4 0 0.545 1.000 1.000 471 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(1), ASPH(3), CREB1(1), EP300(5), EPO(1), LDHA(1), NOS3(7) 12947005 19 11 19 8 8 1 2 7 1 0 0.694 1.000 1.000 472 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 AKT1(1), CALM3(1), CHRM1(2), CHRNA1(4), FLT1(5), FLT4(6), KDR(6), NOS3(7), PDE2A(4), PDE3A(2), PRKACG(1), PRKAR1A(2), PRKG1(1), PRKG2(1), RYR2(28), SLC7A1(2), SYT1(1), TNNI1(1) 30758382 75 55 75 28 23 11 17 15 9 0 0.406 1.000 1.000 473 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(4), ACTB(2), ACTG1(1), ARHGEF2(5), CD14(1), CDH1(4), CLDN1(1), CTNNB1(3), CTTN(1), FYN(1), HCLS1(1), ITGB1(2), KRT18(1), NCK1(2), NCL(2), OCLN(2), PRKCA(5), ROCK1(2), ROCK2(4), TLR4(2), TLR5(2), TUBA1A(2), TUBA3C(5), TUBA3D(1), TUBA4A(1), TUBA8(1), TUBB(1), TUBB6(3), TUBB8(3), WAS(2), WASL(2), YWHAQ(1), YWHAZ(1) 40091357 71 40 71 25 25 10 11 14 10 1 0.288 1.000 1.000 474 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(4), ACTB(2), ACTG1(1), ARHGEF2(5), CD14(1), CDH1(4), CLDN1(1), CTNNB1(3), CTTN(1), FYN(1), HCLS1(1), ITGB1(2), KRT18(1), NCK1(2), NCL(2), OCLN(2), PRKCA(5), ROCK1(2), ROCK2(4), TLR4(2), TLR5(2), TUBA1A(2), TUBA3C(5), TUBA3D(1), TUBA4A(1), TUBA8(1), TUBB(1), TUBB6(3), TUBB8(3), WAS(2), WASL(2), YWHAQ(1), YWHAZ(1) 40091357 71 40 71 25 25 10 11 14 10 1 0.288 1.000 1.000 475 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ADCY1(2), ADCY8(1), ARAF(1), ATF4(1), BRAF(6), CACNA1C(2), CALM3(1), CALML3(1), CALML6(1), CAMK2A(2), CAMK2D(1), CAMK2G(2), CAMK4(2), CREBBP(9), EP300(5), GRIA1(5), GRIA2(2), GRIN1(2), GRIN2A(7), GRIN2B(6), GRIN2C(4), GRIN2D(4), GRM1(4), GRM5(4), ITPR1(4), ITPR2(12), ITPR3(13), KRAS(3), MAP2K2(1), MAPK1(2), MAPK3(1), NRAS(4), PLCB1(3), PLCB2(4), PLCB3(4), PLCB4(3), PPP1CA(1), PPP1CB(1), PPP1R12A(1), PPP3CA(1), PPP3CC(1), PRKACG(1), PRKCA(5), PRKCG(2), RAF1(1), RAPGEF3(1), RPS6KA1(4), RPS6KA2(3), RPS6KA3(3), RPS6KA6(3) 75879731 157 92 155 39 46 14 23 47 24 3 0.0115 1.000 1.000 476 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 58 APC(2), AXIN1(1), CCND1(4), CSNK1E(1), CTNNB1(3), DVL2(1), DVL3(2), FZD1(2), FZD10(2), FZD5(1), FZD6(2), FZD7(2), FZD8(2), FZD9(3), MAPK10(1), MAPK9(1), PAFAH1B1(4), PPP2R5C(1), PPP2R5E(2), PRKCA(5), PRKCG(2), PRKCH(3), PRKCI(2), PRKCQ(2), RAC1(1), SFRP4(1), WNT11(4), WNT16(2), WNT2(3), WNT2B(1), WNT5B(1), WNT7A(2) 45817464 66 40 66 23 24 5 10 12 13 2 0.313 1.000 1.000 477 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 CAD(5), CANT1(3), CDA(1), CTPS2(2), DCK(1), DCTD(1), DHODH(2), DPYD(4), DPYS(4), ENTPD1(3), NT5C(3), NT5E(1), NT5M(1), POLB(3), POLD1(2), POLD2(2), POLE(8), POLG(1), POLL(1), POLQ(4), POLR1B(2), POLR2A(7), POLR2B(3), POLR2C(2), POLR2G(1), POLRMT(1), RRM1(3), TK2(3), UCK1(3), UMPS(1), UPP1(1) 43668317 79 43 78 26 20 14 7 27 11 0 0.461 1.000 1.000 478 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 192 ACTB(2), ACTG1(1), ACTN1(1), ACTN2(6), ACTN4(2), AKT1(1), ARHGAP5(2), BCAR1(3), BIRC2(2), BRAF(6), CCND1(4), CHAD(1), COL11A1(6), COL11A2(4), COL1A1(3), COL1A2(9), COL2A1(5), COL3A1(5), COL4A1(2), COL4A2(4), COL4A4(4), COL4A6(6), COL5A1(4), COL5A2(2), COL5A3(1), COL6A1(4), COL6A2(1), COL6A3(15), COL6A6(4), COMP(1), CRKL(1), CTNNB1(3), DIAPH1(5), DOCK1(1), EGF(7), EGFR(45), ELK1(3), ERBB2(2), FARP2(2), FLNA(13), FLNB(9), FLNC(12), FLT1(5), FN1(6), FYN(1), HGF(3), IBSP(1), IGF1(1), IGF1R(7), ILK(1), ITGA1(2), ITGA10(4), ITGA11(2), ITGA2(4), ITGA2B(1), ITGA4(5), ITGA5(2), ITGA6(3), ITGA7(2), ITGA8(5), ITGAV(2), ITGB1(2), ITGB3(2), ITGB4(5), ITGB6(7), ITGB7(4), ITGB8(1), KDR(6), LAMA1(8), LAMA2(11), LAMA3(11), LAMA4(4), LAMA5(12), LAMB1(4), LAMB2(1), LAMB3(1), LAMB4(5), LAMC1(3), LAMC2(4), LAMC3(3), MAPK1(2), MAPK10(1), MAPK3(1), MAPK8(2), MAPK9(1), MET(10), MYL2(2), MYL5(1), MYLK(5), MYLK2(1), PAK1(2), PAK2(2), PAK3(3), PAK4(1), PAK6(3), PAK7(4), PARVA(1), PARVB(2), PDGFA(1), PDGFC(2), PDGFD(2), PDGFRA(18), PDGFRB(1), PGF(1), PIK3CA(50), PIK3CB(3), PIK3CD(3), PIK3CG(5), PIK3R1(23), PIK3R2(1), PIK3R3(1), PIK3R5(1), PIP5K1C(1), PPP1CA(1), PPP1CB(1), PPP1R12A(1), PRKCA(5), PRKCG(2), PTEN(25), PTK2(2), RAC1(1), RAC2(1), RAF1(1), RAPGEF1(4), RELN(12), ROCK1(2), ROCK2(4), SHC1(1), SHC2(1), SHC3(1), SHC4(1), SOS1(4), SOS2(5), SPP1(2), THBS1(4), THBS2(6), THBS3(4), THBS4(3), TLN1(5), TLN2(6), TNC(8), TNN(6), TNR(5), TNXB(11), VAV1(5), VAV2(2), VAV3(2), VCL(1), VEGFA(2), VEGFB(2), VEGFC(2), VWF(7) 282651719 680 278 628 173 169 136 95 163 111 6 2.16e-07 1.000 1.000 479 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 203 ABI2(2), ACTN1(1), ACTN2(6), ACTN4(2), APC(2), ARAF(1), ARHGEF1(1), ARHGEF12(3), ARHGEF4(4), ARHGEF6(5), ARPC1A(1), ARPC1B(2), ARPC3(1), BAIAP2(3), BCAR1(3), BRAF(6), CD14(1), CFL1(1), CFL2(1), CHRM1(2), CHRM3(3), CHRM4(1), CHRM5(4), CRKL(1), CSK(1), CYFIP2(4), DIAPH1(5), DIAPH2(2), DIAPH3(2), DOCK1(1), EGF(7), EGFR(45), F2(3), F2R(2), FGD1(1), FGD3(2), FGF13(2), FGF14(1), FGF16(1), FGF4(1), FGF5(3), FGF6(1), FGF7(1), FGFR1(2), FGFR2(2), FGFR3(2), FGFR4(3), FN1(6), GIT1(2), GNA13(1), GNG12(1), GSN(1), IQGAP1(9), IQGAP2(5), IQGAP3(1), ITGA1(2), ITGA10(4), ITGA11(2), ITGA2(4), ITGA2B(1), ITGA4(5), ITGA5(2), ITGA6(3), ITGA7(2), ITGA8(5), ITGAD(2), ITGAE(6), ITGAL(2), ITGAM(2), ITGAV(2), ITGAX(2), ITGB1(2), ITGB2(1), ITGB3(2), ITGB4(5), ITGB6(7), ITGB7(4), ITGB8(1), KRAS(3), LIMK1(4), MAP2K2(1), MAPK1(2), MAPK3(1), MRAS(1), MSN(1), MYH10(7), MYH14(4), MYL2(2), MYL5(1), MYLK(5), MYLK2(1), NCKAP1(4), NCKAP1L(3), NRAS(4), PAK1(2), PAK2(2), PAK3(3), PAK4(1), PAK6(3), PAK7(4), PDGFA(1), PDGFRA(18), PDGFRB(1), PFN4(1), PIK3CA(50), PIK3CB(3), PIK3CD(3), PIK3CG(5), PIK3R1(23), PIK3R2(1), PIK3R3(1), PIK3R5(1), PIP4K2A(1), PIP4K2B(1), PIP4K2C(2), PIP5K1B(1), PIP5K1C(1), PPP1CA(1), PPP1CB(1), PPP1R12A(1), PTK2(2), RAC1(1), RAC2(1), RAF1(1), RDX(5), ROCK1(2), ROCK2(4), RRAS(1), SCIN(2), SOS1(4), SOS2(5), SSH1(2), SSH2(1), SSH3(2), TIAM1(5), TIAM2(9), VAV1(5), VAV2(2), VAV3(2), VCL(1), WAS(2), WASF1(1), WASF2(1), WASL(2) 210482784 484 227 436 131 97 90 75 129 90 3 0.000628 1.000 1.000 480 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 168 ADCY1(2), ADCY2(4), ADCY3(2), ADCY4(5), ADCY7(2), ADCY8(1), ADCY9(7), ADRA1A(2), ADRA1B(2), ADRB2(1), ATP2A1(1), ATP2A2(4), ATP2A3(2), ATP2B2(4), ATP2B3(6), AVPR1A(4), AVPR1B(1), CACNA1A(3), CACNA1B(9), CACNA1C(2), CACNA1D(7), CACNA1E(7), CACNA1F(6), CACNA1G(7), CACNA1H(7), CACNA1I(6), CACNA1S(7), CALM3(1), CALML3(1), CALML6(1), CAMK2A(2), CAMK2D(1), CAMK2G(2), CAMK4(2), CCKBR(2), CHRM1(2), CHRM3(3), CHRM5(4), CHRNA7(1), CYSLTR1(2), CYSLTR2(1), EDNRA(1), EDNRB(1), EGFR(45), ERBB2(2), ERBB3(4), ERBB4(5), F2R(2), GNA11(1), GNA14(3), GNA15(1), GNAL(1), GNAS(4), GRIN1(2), GRIN2A(7), GRIN2C(4), GRIN2D(4), GRM1(4), GRM5(4), GRPR(3), HRH1(3), HTR2A(1), HTR2B(2), HTR2C(3), HTR4(1), HTR5A(4), HTR6(1), HTR7(1), ITPR1(4), ITPR2(12), ITPR3(13), LTB4R2(1), MYLK(5), MYLK2(1), NOS1(5), NOS3(7), NTSR1(1), P2RX1(2), P2RX2(1), P2RX3(1), P2RX4(1), P2RX5(1), P2RX7(1), PDE1A(1), PDE1B(2), PDE1C(5), PDGFRA(18), PDGFRB(1), PHKA1(3), PHKA2(5), PHKB(1), PHKG1(2), PLCB1(3), PLCB2(4), PLCB3(4), PLCB4(3), PLCD1(1), PLCD3(2), PLCE1(8), PLCG1(6), PLCG2(9), PLCZ1(4), PPID(1), PPP3CA(1), PPP3CC(1), PRKACG(1), PRKCA(5), PRKCG(2), PTAFR(1), PTGER3(1), PTGFR(6), PTK2B(2), RYR1(11), RYR2(28), RYR3(11), SLC25A4(1), SLC25A5(4), SLC25A6(1), SLC8A1(3), SLC8A2(3), SLC8A3(2), TACR2(2), TACR3(3), TBXA2R(1), TNNC1(1), TRHR(2), TRPC1(1), VDAC2(1), VDAC3(3) 205152495 487 216 466 158 160 91 58 109 66 3 0.00390 1.000 1.000 481 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 236 ADCYAP1R1(4), ADORA3(2), ADRA1A(2), ADRA1B(2), ADRA2A(1), ADRA2B(1), ADRA2C(1), ADRB2(1), AGTR2(3), AVPR1A(4), AVPR1B(1), AVPR2(3), BRS3(1), C3AR1(3), C5AR1(1), CALCR(1), CCKBR(2), CHRM1(2), CHRM3(3), CHRM4(1), CHRM5(4), CNR1(1), CNR2(2), CRHR2(3), CTSG(2), CYSLTR1(2), CYSLTR2(1), DRD3(2), DRD5(3), EDNRA(1), EDNRB(1), F2(3), F2R(2), F2RL1(4), F2RL3(1), FPR1(1), FSHR(2), GABBR1(2), GABBR2(1), GABRA1(7), GABRA2(2), GABRA3(2), GABRA4(6), GABRA5(1), GABRA6(4), GABRB1(5), GABRB2(4), GABRB3(1), GABRD(4), GABRE(3), GABRG1(5), GABRG2(2), GABRG3(2), GABRP(3), GABRQ(1), GABRR1(3), GALR1(1), GH1(1), GH2(2), GHR(4), GHRHR(2), GIPR(2), GLP1R(1), GLP2R(1), GLRA1(1), GLRA2(1), GLRA3(2), GLRB(4), GNRHR(2), GPR156(1), GPR35(1), GPR50(2), GPR63(1), GPR83(2), GRIA1(5), GRIA2(2), GRIA3(6), GRIA4(4), GRID1(2), GRID2(3), GRIK1(4), GRIK2(3), GRIK3(2), GRIK4(5), GRIK5(3), GRIN1(2), GRIN2A(7), GRIN2B(6), GRIN2C(4), GRIN2D(4), GRIN3A(3), GRIN3B(1), GRM1(4), GRM2(4), GRM3(7), GRM4(4), GRM5(4), GRM6(3), GRM7(3), GRM8(2), GRPR(3), GZMA(1), HCRTR2(2), HRH1(3), HRH4(2), HTR1A(1), HTR1B(1), HTR1D(2), HTR1E(1), HTR1F(2), HTR2A(1), HTR2B(2), HTR2C(3), HTR4(1), HTR5A(4), HTR6(1), HTR7(1), LEPR(2), LTB4R(1), LTB4R2(1), MC1R(3), MC3R(2), MC4R(3), MC5R(3), MCHR1(1), MCHR2(1), MLNR(1), MTNR1A(2), MTNR1B(1), NMBR(5), NMUR1(3), NMUR2(2), NPBWR1(1), NPBWR2(2), NPY1R(3), NPY2R(1), NR3C1(3), NTSR1(1), OPRD1(1), OPRK1(1), OPRL1(1), OPRM1(2), P2RX1(2), P2RX2(1), P2RX3(1), P2RX4(1), P2RX5(1), P2RX7(1), P2RY1(1), P2RY11(3), P2RY13(1), P2RY2(2), P2RY4(1), P2RY6(2), P2RY8(3), PARD3(2), PRL(1), PRLR(2), PRSS1(1), PRSS3(2), PTAFR(1), PTGER3(1), PTGER4(1), PTGFR(6), PTH2R(2), RXFP1(2), RXFP2(5), SCTR(1), SSTR2(2), SSTR3(5), SSTR4(8), TAAR2(2), TAAR5(1), TAAR6(1), TAAR8(1), TACR2(2), TACR3(3), TBXA2R(1), THRA(2), THRB(2), TRHR(2), TRPV1(2), TSHR(4), UTS2R(1), VIPR1(1), VIPR2(1) 169224991 426 192 423 134 146 75 50 107 48 0 0.00121 1.000 1.000 482 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 ACTB(2), ACTG1(1), CHAD(1), COL11A1(6), COL11A2(4), COL17A1(2), COL1A1(3), COL1A2(9), COL2A1(5), COL3A1(5), COL4A1(2), COL4A2(4), COL4A4(4), COL4A6(6), COL5A1(4), COL5A2(2), COL5A3(1), COL6A1(4), COL6A2(1), COL6A3(15), COL6A6(4), COMP(1), DSC1(3), DSC2(2), DSC3(6), DSG1(6), DSG2(7), DSG3(2), DSG4(2), FN1(6), GJA1(5), GJA10(1), GJA3(1), GJA4(1), GJA8(1), GJB2(1), GJB4(1), GJB6(2), GJC3(1), GJD4(1), IBSP(1), INA(1), ITGA6(3), ITGB4(5), KRT1(3), KRT12(1), KRT13(3), KRT14(1), KRT15(6), KRT16(3), KRT17(2), KRT18(1), KRT19(1), KRT2(2), KRT20(3), KRT23(1), KRT24(2), KRT25(2), KRT27(2), KRT28(5), KRT3(4), KRT31(3), KRT33A(5), KRT33B(2), KRT34(2), KRT35(3), KRT36(4), KRT37(3), KRT39(2), KRT40(1), KRT5(4), KRT6A(2), KRT6B(4), KRT6C(3), KRT7(1), KRT71(4), KRT73(5), KRT75(4), KRT76(1), KRT77(1), KRT78(2), KRT79(3), KRT8(4), KRT81(3), KRT82(1), KRT83(4), KRT84(3), KRT86(3), KRT9(1), LAMA1(8), LAMA2(11), LAMA3(11), LAMA4(4), LAMA5(12), LAMB1(4), LAMB2(1), LAMB3(1), LAMB4(5), LAMC1(3), LAMC2(4), LAMC3(3), LMNA(2), LMNB2(2), NES(2), PRPH(1), RELN(12), SPP1(2), THBS1(4), THBS2(6), THBS3(4), THBS4(3), TNC(8), TNN(6), TNR(5), TNXB(11), VIM(2), VWF(7) 189688234 409 186 403 148 152 92 36 89 38 2 0.0641 1.000 1.000 483 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 131 ACTB(2), ACTG1(1), ACTN1(1), ACTN2(6), ACTN4(2), AKT1(1), AMOTL1(4), ASH1L(5), CASK(2), CDK4(1), CGN(1), CLDN1(1), CLDN11(1), CLDN14(1), CLDN16(2), CLDN19(2), CLDN2(2), CLDN22(1), CLDN7(1), CLDN8(1), CRB3(2), CSNK2A1(2), CSNK2B(1), CTNNA2(3), CTNNA3(3), CTNNB1(3), CTTN(1), EPB41L1(2), EPB41L2(7), EPB41L3(7), EXOC3(1), EXOC4(3), F11R(1), GNAI1(4), GNAI2(1), GNAI3(2), HCLS1(1), INADL(5), JAM2(4), JAM3(2), KRAS(3), LLGL1(3), LLGL2(3), MAGI1(4), MAGI2(4), MAGI3(5), MLLT4(7), MPDZ(10), MRAS(1), MYH1(12), MYH10(7), MYH11(9), MYH13(11), MYH14(4), MYH15(7), MYH2(16), MYH3(9), MYH4(15), MYH6(5), MYH7(11), MYH7B(9), MYH8(15), MYL2(2), MYL5(1), NRAS(4), OCLN(2), PARD3(2), PARD6A(1), PARD6B(2), PPM1J(2), PPP2CA(4), PPP2CB(1), PPP2R1B(1), PPP2R2A(4), PPP2R2C(3), PPP2R3A(3), PPP2R4(1), PRKCA(5), PRKCG(2), PRKCH(3), PRKCI(2), PRKCQ(2), PTEN(25), RAB3B(1), RRAS(1), SPTAN1(5), SYMPK(3), TJAP1(1), TJP1(5), TJP2(1), TJP3(3), YES1(2), ZAK(2) 147774777 359 182 354 93 123 46 47 91 50 2 0.000619 1.000 1.000 484 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 250 ACVR1(3), ACVR1B(3), ACVR2A(2), AMHR2(1), BMPR1A(1), BMPR1B(1), CCL1(1), CCL11(2), CCL16(1), CCL20(1), CCL26(2), CCL27(1), CCL5(1), CCR2(2), CCR3(1), CCR4(1), CCR6(2), CCR7(1), CCR8(1), CCR9(2), CD40(1), CD40LG(2), CD70(1), CLCF1(1), CNTF(1), CNTFR(2), CRLF2(3), CSF1R(4), CSF2RA(7), CSF2RB(2), CSF3R(2), CX3CL1(1), CX3CR1(1), CXCL13(1), CXCL9(1), CXCR4(2), CXCR6(1), EDA(1), EDAR(6), EGF(7), EGFR(45), EPO(1), EPOR(1), FAS(1), FASLG(1), FLT1(5), FLT3(4), FLT4(6), GDF5(1), GH1(1), GH2(2), GHR(4), HGF(3), IFNA21(4), IFNA5(1), IFNA6(1), IFNA7(1), IFNA8(1), IFNAR1(2), IFNAR2(1), IFNB1(1), IFNGR2(1), IFNK(1), IFNW1(2), IL10(1), IL10RB(1), IL12B(2), IL12RB1(2), IL12RB2(2), IL13RA1(3), IL15(2), IL17B(1), IL17RA(1), IL17RB(1), IL18(3), IL18R1(2), IL18RAP(3), IL19(1), IL1B(2), IL1R1(2), IL1R2(3), IL1RAP(1), IL20RA(2), IL21R(1), IL22RA1(1), IL23A(1), IL23R(5), IL26(1), IL2RB(2), IL3(1), IL3RA(2), IL4R(2), IL5(1), IL5RA(2), IL6(1), IL6R(1), IL6ST(3), IL7R(1), IL9(1), IL9R(2), INHBB(1), INHBE(2), KDR(6), KIT(6), KITLG(2), LEPR(2), LIFR(2), LTB(1), LTBR(2), MET(10), MPL(2), NGFR(1), OSMR(3), PDGFC(2), PDGFRA(18), PDGFRB(1), PLEKHO2(1), PPBP(1), PRL(1), PRLR(2), RELT(3), TGFB2(2), TGFB3(1), TGFBR1(2), TGFBR2(3), TNF(1), TNFRSF10C(1), TNFRSF10D(1), TNFRSF11A(2), TNFRSF11B(2), TNFRSF13B(1), TNFRSF14(1), TNFRSF17(1), TNFRSF1B(2), TNFRSF21(2), TNFRSF25(1), TNFRSF6B(1), TNFRSF8(2), TNFRSF9(3), TNFSF13B(1), TNFSF14(5), TNFSF15(3), TNFSF8(2), TNFSF9(2), TPO(6), VEGFA(2), VEGFB(2), VEGFC(2), XCL1(1) 135028801 355 170 334 112 82 75 56 94 48 0 0.0138 1.000 1.000 485 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 131 ACACA(12), ACACB(11), AKT1(1), ARAF(1), BRAF(6), CALM3(1), CALML3(1), CALML6(1), CBL(1), CBLB(2), CBLC(2), CRKL(1), ELK1(3), EXOC7(1), FASN(3), FBP1(1), FBP2(1), FLOT2(3), G6PC(7), G6PC2(1), GCK(2), GYS1(1), GYS2(2), IKBKB(1), INPP5D(2), INSR(4), IRS1(4), IRS2(1), IRS4(5), KRAS(3), LIPE(3), MAP2K2(1), MAPK1(2), MAPK10(1), MAPK3(1), MAPK8(2), MAPK9(1), MKNK1(2), NRAS(4), PCK1(3), PDE3A(2), PFKL(4), PFKP(1), PHKA1(3), PHKA2(5), PHKB(1), PHKG1(2), PIK3CA(50), PIK3CB(3), PIK3CD(3), PIK3CG(5), PIK3R1(23), PIK3R2(1), PIK3R3(1), PIK3R5(1), PKLR(3), PPARGC1A(1), PPP1CA(1), PPP1CB(1), PPP1R3A(6), PPP1R3C(1), PRKAA1(3), PRKAA2(2), PRKACG(1), PRKAG1(1), PRKAG2(1), PRKAR1A(2), PRKCI(2), PTPN1(1), PTPRF(5), PYGB(1), PYGL(5), PYGM(1), RAF1(1), RAPGEF1(4), RPS6KB1(2), RPS6KB2(3), SH2B2(1), SHC1(1), SHC2(1), SHC3(1), SHC4(1), SLC2A4(1), SOCS4(2), SORBS1(1), SOS1(4), SOS2(5), SREBF1(6), TSC1(2), TSC2(3) 122172215 287 162 258 77 60 50 48 69 56 4 0.00758 1.000 1.000 486 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 127 ABL1(4), ABLIM1(3), ABLIM2(2), ABLIM3(5), ARHGEF12(3), CFL1(1), CFL2(1), CXCR4(2), DCC(6), EFNA1(1), EFNA3(3), EFNA5(1), EFNB1(2), EFNB2(1), EFNB3(1), EPHA2(2), EPHA3(7), EPHA4(7), EPHA5(5), EPHA6(1), EPHA7(5), EPHA8(5), EPHB1(2), EPHB2(2), EPHB3(1), EPHB4(4), EPHB6(6), FES(5), FYN(1), GNAI1(4), GNAI2(1), GNAI3(2), ITGB1(2), KRAS(3), L1CAM(7), LIMK1(4), LRRC4C(4), MAPK1(2), MAPK3(1), MET(10), NCK1(2), NFAT5(3), NFATC1(2), NFATC2(5), NFATC3(2), NFATC4(3), NGEF(6), NRAS(4), NRP1(4), NTN1(1), NTN4(2), NTNG1(1), PAK1(2), PAK2(2), PAK3(3), PAK4(1), PAK6(3), PAK7(4), PLXNA1(10), PLXNA2(6), PLXNA3(6), PLXNB1(6), PLXNB2(3), PLXNB3(8), PLXNC1(2), PPP3CA(1), PPP3CC(1), PTK2(2), RAC1(1), RAC2(1), RASA1(4), RGS3(9), RHOD(1), RND1(1), ROBO1(4), ROBO2(9), ROBO3(5), ROCK1(2), ROCK2(4), SEMA3A(5), SEMA3C(1), SEMA3D(3), SEMA3E(6), SEMA3F(2), SEMA4A(2), SEMA4B(1), SEMA4D(2), SEMA4F(3), SEMA4G(3), SEMA5B(1), SEMA6A(3), SEMA6B(4), SEMA6C(2), SEMA6D(5), SEMA7A(3), SLIT1(7), SLIT2(5), SLIT3(2), SRGAP1(2), SRGAP2(3), SRGAP3(1), UNC5A(1), UNC5B(1), UNC5C(2), UNC5D(1) 150437752 336 153 333 101 98 50 49 87 51 1 0.0119 1.000 1.000 487 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 110 ACTN1(1), ACTN2(6), ACTN4(2), ARHGAP5(2), BCAR1(3), CDH5(2), CLDN1(1), CLDN11(1), CLDN14(1), CLDN16(2), CLDN19(2), CLDN2(2), CLDN22(1), CLDN7(1), CLDN8(1), CTNNA2(3), CTNNA3(3), CTNNB1(3), CTNND1(1), CXCR4(2), CYBA(1), CYBB(1), ESAM(1), F11R(1), GNAI1(4), GNAI2(1), GNAI3(2), ICAM1(2), ITGA4(5), ITGAL(2), ITGAM(2), ITGB1(2), ITGB2(1), ITK(1), JAM2(4), JAM3(2), MAPK12(2), MAPK13(1), MLLT4(7), MMP9(2), MSN(1), MYL2(2), MYL5(1), NCF1(2), NCF2(3), NCF4(1), NOX1(1), NOX3(1), OCLN(2), PIK3CA(50), PIK3CB(3), PIK3CD(3), PIK3CG(5), PIK3R1(23), PIK3R2(1), PIK3R3(1), PIK3R5(1), PLCG1(6), PLCG2(9), PRKCA(5), PRKCG(2), PTK2(2), PTK2B(2), PTPN11(7), RAC1(1), RAC2(1), RAPGEF3(1), RAPGEF4(2), RHOH(1), ROCK1(2), ROCK2(4), SIPA1(2), TXK(1), VAV1(5), VAV2(2), VAV3(2), VCAM1(1), VCL(1) 94733940 244 144 214 75 56 41 43 52 50 2 0.0886 1.000 1.000 488 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(1), CD36(4), CD44(3), CHAD(1), COL11A1(6), COL11A2(4), COL1A1(3), COL1A2(9), COL2A1(5), COL3A1(5), COL4A1(2), COL4A2(4), COL4A4(4), COL4A6(6), COL5A1(4), COL5A2(2), COL5A3(1), COL6A1(4), COL6A2(1), COL6A3(15), COL6A6(4), DAG1(1), FN1(6), FNDC1(4), FNDC3A(5), FNDC5(1), GP5(2), GP9(1), HMMR(1), HSPG2(16), IBSP(1), ITGA1(2), ITGA10(4), ITGA11(2), ITGA2(4), ITGA2B(1), ITGA4(5), ITGA5(2), ITGA6(3), ITGA7(2), ITGA8(5), ITGAV(2), ITGB1(2), ITGB3(2), ITGB4(5), ITGB6(7), ITGB7(4), ITGB8(1), LAMA1(8), LAMA2(11), LAMA3(11), LAMA4(4), LAMA5(12), LAMB1(4), LAMB2(1), LAMB3(1), LAMB4(5), LAMC1(3), LAMC2(4), LAMC3(3), RELN(12), SDC1(1), SDC3(1), SPP1(2), SV2A(2), SV2B(3), SV2C(2), THBS1(4), THBS2(6), THBS3(4), THBS4(3), TNC(8), TNN(6), TNR(5), TNXB(11), VWF(7) 170265532 323 142 321 103 104 76 36 70 35 2 0.0111 1.000 1.000 489 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 92 ADCY1(2), ADCY2(4), ADCY3(2), ADCY4(5), ADCY5(2), ADCY7(2), ADCY8(1), ADCY9(7), CSNK1D(1), EGF(7), EGFR(45), GJA1(5), GNA11(1), GNAI1(4), GNAI2(1), GNAI3(2), GNAS(4), GRM1(4), GRM5(4), GUCY1A2(2), GUCY1A3(2), GUCY2C(4), GUCY2F(3), HTR2A(1), HTR2B(2), HTR2C(3), ITPR1(4), ITPR2(12), ITPR3(13), KRAS(3), MAP2K2(1), MAP2K5(2), MAPK1(2), MAPK3(1), MAPK7(5), NPR1(1), NPR2(3), NRAS(4), PDGFA(1), PDGFC(2), PDGFD(2), PDGFRA(18), PDGFRB(1), PLCB1(3), PLCB2(4), PLCB3(4), PLCB4(3), PRKACG(1), PRKCA(5), PRKCG(2), PRKG1(1), PRKG2(1), RAF1(1), SOS1(4), SOS2(5), TJP1(5), TUBA1A(2), TUBA3C(5), TUBA3D(1), TUBA4A(1), TUBA8(1), TUBB(1), TUBB6(3), TUBB8(3) 100958586 251 140 231 72 69 45 32 65 37 3 0.0125 1.000 1.000 490 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(2), ADCY2(4), ADCY3(2), ADCY4(5), ADCY5(2), ADCY7(2), ADCY8(1), ADCY9(7), ADRA1A(2), ADRA1B(2), ADRB2(1), ANXA6(3), ARRB1(2), ARRB2(1), ATP1B1(1), ATP1B2(1), ATP2A2(4), ATP2A3(2), ATP2B2(4), ATP2B3(6), CACNA1A(3), CACNA1B(9), CACNA1C(2), CACNA1D(7), CACNA1E(7), CACNA1S(7), CACNB3(2), CALM3(1), CALR(2), CAMK1(1), CAMK2A(2), CAMK2D(1), CAMK2G(2), CAMK4(2), CASQ1(2), CASQ2(2), CHRM1(2), CHRM3(3), CHRM4(1), CHRM5(4), GJA1(5), GJA4(1), GJB2(1), GJB4(1), GJB6(2), GNA11(1), GNAI2(1), GNAI3(2), GNAO1(2), GNAZ(1), GNB2(2), GNB3(1), GNB5(1), GNG12(1), GRK4(5), GRK5(4), ITPR1(4), ITPR2(12), ITPR3(13), KCNB1(3), KCNJ3(1), KCNJ5(3), MIB1(1), MYCBP(1), PEA15(1), PLCB3(4), PRKAR1A(2), PRKCA(5), PRKCG(2), PRKCH(3), PRKCQ(2), RGS11(1), RGS18(2), RGS19(1), RGS3(9), RGS4(2), RGS6(2), RGS7(3), RGS9(1), RYR1(11), RYR2(28), RYR3(11), SFN(2), SLC8A1(3), SLC8A3(2), USP5(1), YWHAB(2), YWHAH(1), YWHAQ(1) 142683625 287 137 286 102 101 45 42 53 43 3 0.138 1.000 1.000 491 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA2(2), ADCY1(2), ADCY2(4), ADCY3(2), ADCY4(5), ADCY5(2), ADCY7(2), ADCY8(1), ADCY9(7), ARRB1(2), ARRB2(1), ATF1(1), ATF2(2), ATF4(1), ATF5(2), ATP2A2(4), ATP2A3(2), CACNB3(2), CALM3(1), CAMK2A(2), CAMK2D(1), CAMK2G(2), CNN2(2), CORIN(3), DGKZ(1), FOS(1), GABPA(2), GBA2(1), GJA1(5), GNB2(2), GNB3(1), GNB5(1), GNG12(1), GRK4(5), GRK5(4), GUCY1A3(2), IGFBP2(1), IGFBP6(1), IL1B(2), IL6(1), ITPR1(4), ITPR2(12), ITPR3(13), MIB1(1), MYL2(2), MYLK2(1), NFKB1(1), NOS1(5), NOS3(7), PDE4B(1), PDE4D(6), PLCB3(4), PLCD1(1), PLCG1(6), PLCG2(9), PRKAR1A(2), PRKCA(5), PRKCH(3), PRKCQ(2), RAMP3(1), RGS11(1), RGS18(2), RGS19(1), RGS3(9), RGS4(2), RGS6(2), RGS7(3), RGS9(1), RLN1(1), RYR1(11), RYR2(28), RYR3(11), SFN(2), SLC8A1(3), TNXB(11), USP5(1), YWHAB(2), YWHAH(1), YWHAQ(1) 131649080 265 128 263 98 89 38 40 57 38 3 0.290 1.000 1.000 492 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY1(2), ADCY2(4), ADCY3(2), ADCY4(5), ADCY5(2), ADCY7(2), ADCY8(1), ADCY9(7), ATF4(1), CACNA1C(2), CACNA1D(7), CACNA1F(6), CACNA1S(7), CALM3(1), CALML3(1), CALML6(1), CAMK2A(2), CAMK2D(1), CAMK2G(2), EGFR(45), ELK1(3), GNA11(1), GNAS(4), GNRHR(2), HBEGF(1), ITPR1(4), ITPR2(12), ITPR3(13), KRAS(3), MAP2K2(1), MAP2K3(3), MAP3K1(3), MAP3K3(2), MAP3K4(4), MAPK1(2), MAPK10(1), MAPK12(2), MAPK13(1), MAPK3(1), MAPK7(5), MAPK8(2), MAPK9(1), NRAS(4), PLA2G12B(1), PLA2G2D(1), PLA2G3(4), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLCB1(3), PLCB2(4), PLCB3(4), PLCB4(3), PLD1(7), PRKACG(1), PRKCA(5), PTK2B(2), RAF1(1), SOS1(4), SOS2(5) 97028810 228 123 210 66 70 38 31 57 29 3 0.00735 1.000 1.000 493 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 82 ACVR1(3), ACVR1B(3), ACVRL1(5), AKT1(1), BMPR1A(1), BUB1(4), CDS2(2), CLK1(2), CLK2(1), CLK4(2), CSNK2A1(2), CSNK2B(1), DGKA(3), DGKB(2), DGKD(3), DGKE(1), DGKG(2), DGKH(3), DGKQ(2), DGKZ(1), INPP4A(1), INPP4B(4), INPPL1(5), MAP3K10(1), NEK1(2), NEK3(2), OCRL(5), PAK4(1), PIK3C2A(4), PIK3C2B(2), PIK3C2G(1), PIK3CA(50), PIK3CB(3), PIK3CG(5), PIM2(2), PLCB1(3), PLCB2(4), PLCB3(4), PLCB4(3), PLCD1(1), PLCG1(6), PLCG2(9), PLK3(1), PRKACG(1), PRKAR1A(2), PRKCA(5), PRKCG(2), PRKCH(3), PRKCQ(2), PRKG1(1), RAF1(1), RPS6KA1(4), RPS6KA2(3), RPS6KA3(3), RPS6KB1(2), STK11(1), TGFBR1(2), VRK1(3) 85856202 198 123 176 55 46 36 34 43 36 3 0.0367 1.000 1.000 494 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 130 ALCAM(2), CADM1(3), CD22(3), CD226(1), CD274(1), CD276(1), CD28(1), CD4(1), CD40(1), CD40LG(2), CD58(1), CD86(1), CDH1(4), CDH15(1), CDH2(2), CDH3(3), CDH4(6), CDH5(2), CLDN1(1), CLDN11(1), CLDN14(1), CLDN16(2), CLDN19(2), CLDN2(2), CLDN22(1), CLDN7(1), CLDN8(1), CNTN1(2), CNTN2(2), CNTNAP1(4), CNTNAP2(4), CTLA4(1), ESAM(1), F11R(1), GLG1(2), HLA-A(1), HLA-C(1), HLA-DMA(2), HLA-DMB(4), HLA-DOA(1), HLA-DPB1(1), HLA-DQA1(1), HLA-DQA2(2), HLA-DRA(3), HLA-DRB1(1), HLA-DRB5(1), HLA-E(1), HLA-F(1), ICAM1(2), ICAM2(1), ICOS(1), ICOSLG(2), ITGA4(5), ITGA6(3), ITGA8(5), ITGAL(2), ITGAM(2), ITGAV(2), ITGB1(2), ITGB2(1), ITGB7(4), ITGB8(1), JAM2(4), JAM3(2), L1CAM(7), MAG(2), MPZ(1), NCAM1(2), NEGR1(3), NEO1(8), NFASC(1), NLGN1(3), NLGN2(4), NLGN3(4), NRCAM(5), NRXN1(5), NRXN3(5), OCLN(2), PDCD1LG2(1), PTPRC(7), PTPRF(5), PTPRM(7), PVR(2), PVRL1(1), PVRL3(2), SDC1(1), SDC3(1), SELE(6), SELP(2), SELPLG(1), SIGLEC1(4), SPN(1), VCAM1(1), VCAN(7) 112548450 225 114 223 87 63 47 22 55 38 0 0.359 1.000 1.000 495 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADA(1), ADCY1(2), ADCY2(4), ADCY3(2), ADCY4(5), ADCY5(2), ADCY7(2), ADCY8(1), ADCY9(7), ADK(1), ADSL(4), ADSSL1(1), AK5(2), AK7(4), ALLC(2), AMPD1(5), AMPD2(3), AMPD3(1), ATIC(1), CANT1(3), DCK(1), ENPP1(4), ENPP3(2), ENTPD1(3), ENTPD5(1), ENTPD6(2), ENTPD8(1), GART(4), GDA(1), GMPR(1), GMPR2(2), GUCY1A2(2), GUCY1A3(2), GUCY2C(4), GUCY2F(3), HPRT1(1), IMPDH1(3), NPR1(1), NPR2(3), NT5C(3), NT5C1A(1), NT5C1B(5), NT5C2(1), NT5E(1), NT5M(1), PAICS(2), PDE10A(1), PDE11A(4), PDE1A(1), PDE1C(5), PDE2A(4), PDE4A(1), PDE4B(1), PDE4C(1), PDE4D(6), PDE5A(1), PDE7A(2), PDE7B(2), PDE8A(6), PDE8B(1), PDE9A(2), PFAS(6), PKLR(3), POLA1(2), POLA2(1), POLD1(2), POLD2(2), POLD3(2), POLE(8), POLR1A(5), POLR1B(2), POLR2A(7), POLR2B(3), POLR2C(2), POLR2G(1), POLR3A(7), POLR3B(2), POLR3GL(1), POLR3K(1), PPAT(2), PRIM1(1), PRIM2(1), PRPS1(1), PRPS1L1(1), PRPS2(3), RRM1(3), RRM2B(1), XDH(8) 124440620 224 113 223 79 66 41 25 58 34 0 0.244 1.000 1.000 496 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA2(2), ACTN2(6), ACTN4(2), DMD(12), MYBPC1(4), MYBPC2(4), MYH3(9), MYH6(5), MYH7(11), MYH8(15), MYL1(2), MYL2(2), MYOM1(3), NEB(20), TNNI1(1), TNNT1(1), TNNT3(4), TPM1(6), TPM2(1), TPM3(2), TPM4(1), TTN(119), VIM(2) 103748379 234 113 233 69 71 41 27 71 22 2 0.0583 1.000 1.000 497 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 162 ADORA3(2), ADRA1A(2), ADRA1B(2), ADRA2A(1), ADRA2C(1), ADRB2(1), AGTR2(3), AVPR1A(4), AVPR1B(1), AVPR2(3), BRS3(1), C3AR1(3), CCKBR(2), CCR10(1), CCR2(2), CCR3(1), CCR4(1), CCR6(2), CCR7(1), CCR8(1), CCR9(2), CHML(2), CHRM1(2), CHRM3(3), CHRM4(1), CHRM5(4), CMKLR1(1), CNR1(1), CNR2(2), CX3CR1(1), CXCR4(2), DRD3(2), DRD5(3), EDNRA(1), EDNRB(1), F2R(2), F2RL1(4), F2RL3(1), FPR1(1), FSHR(2), GALR1(1), GNB2L1(2), GPR17(1), GPR173(1), GPR174(1), GPR35(1), GPR37(3), GPR37L1(1), GPR4(1), GPR50(2), GPR6(2), GPR63(1), GPR83(2), GPR85(2), GPR87(1), GRPR(3), HCRTR2(2), HRH1(3), HTR1A(1), HTR1B(1), HTR1D(2), HTR1E(1), HTR1F(2), HTR2A(1), HTR2B(2), HTR2C(3), HTR4(1), HTR5A(4), HTR6(1), HTR7(1), LTB4R(1), MC1R(3), MC3R(2), MC4R(3), MC5R(3), MLNR(1), MTNR1A(2), MTNR1B(1), NMBR(5), NMUR1(3), NMUR2(2), NPY1R(3), NPY2R(1), NTSR1(1), OPN1SW(1), OPRD1(1), OPRK1(1), OPRL1(1), OPRM1(2), OR10A5(2), OR11A1(1), OR1C1(3), OR1F1(1), OR1Q1(1), OR5V1(3), OR7C1(1), P2RY1(1), P2RY11(3), P2RY12(2), P2RY13(1), P2RY2(2), P2RY6(2), PTAFR(1), PTGER4(1), PTGFR(6), RRH(1), SSTR2(2), SSTR3(5), SSTR4(8), SUCNR1(2), TBXA2R(1), TRHR(2) 92831438 212 108 211 78 77 33 31 54 17 0 0.0816 1.000 1.000 498 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 ARAF(1), BRAF(6), CACNA1A(3), GNA11(1), GNA13(1), GNAI1(4), GNAI2(1), GNAI3(2), GNAO1(2), GNAS(4), GNAZ(1), GRIA1(5), GRIA2(2), GRIA3(6), GRID2(3), GRM1(4), GRM5(4), GUCY1A2(2), GUCY1A3(2), GUCY2C(4), GUCY2F(3), IGF1(1), IGF1R(7), ITPR1(4), ITPR2(12), ITPR3(13), KRAS(3), MAP2K2(1), MAPK1(2), MAPK3(1), NOS1(5), NOS3(7), NPR1(1), NPR2(3), NRAS(4), PLA2G12B(1), PLA2G2D(1), PLA2G3(4), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLCB1(3), PLCB2(4), PLCB3(4), PLCB4(3), PPP2CA(4), PPP2CB(1), PPP2R1B(1), PPP2R2A(4), PPP2R2C(3), PRKCA(5), PRKCG(2), PRKG1(1), PRKG2(1), RAF1(1), RYR1(11) 83981379 186 106 184 51 44 24 37 47 31 3 0.0352 1.000 1.000 499 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(5), AMY2B(3), ASCC3(3), ATP13A2(1), DDX19A(2), DDX23(3), DDX4(5), DDX41(2), DDX47(2), DDX51(3), DDX52(2), DDX54(2), DDX55(1), DDX56(3), DHX58(1), ENPP1(4), ENPP3(2), ENTPD7(2), EP400(3), ERCC2(3), ERCC3(2), G6PC(7), G6PC2(1), GAA(5), GANC(5), GBE1(1), GCK(2), GPI(2), GUSB(3), GYS1(1), GYS2(2), HK1(4), HK2(3), HK3(3), IFIH1(3), LYZL1(1), MGAM(7), MOV10L1(3), PGM3(1), PYGB(1), PYGL(5), PYGM(1), RAD54B(3), RAD54L(5), RUVBL2(2), SETX(4), SI(9), SKIV2L2(3), SMARCA2(2), SMARCA5(2), UGDH(1), UGP2(1), UGT1A1(5), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A5(2), UGT1A6(2), UGT1A7(2), UGT2A1(5), UGT2A3(6), UGT2B10(3), UGT2B11(3), UGT2B15(2), UGT2B17(2), UGT2B28(2), UGT2B4(4), UGT2B7(2), UXS1(2) 94292444 194 104 193 48 60 33 25 51 25 0 0.00589 1.000 1.000 500 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 99 ADCY1(2), ADCY2(4), ADCY3(2), ADCY4(5), ADCY5(2), ADCY7(2), ADCY8(1), ADCY9(7), ASIP(1), CALM3(1), CALML3(1), CALML6(1), CAMK2A(2), CAMK2D(1), CAMK2G(2), CREB1(1), CREB3L1(1), CREB3L2(1), CREBBP(9), CTNNB1(3), DVL2(1), DVL3(2), EDNRB(1), EP300(5), FZD1(2), FZD10(2), FZD4(1), FZD5(1), FZD6(2), FZD7(2), FZD8(2), FZD9(3), GNAI1(4), GNAI2(1), GNAI3(2), GNAO1(2), GNAS(4), KIT(6), KITLG(2), KRAS(3), LEF1(1), MAP2K2(1), MAPK1(2), MAPK3(1), MC1R(3), NRAS(4), PLCB1(3), PLCB2(4), PLCB3(4), PLCB4(3), PRKACG(1), PRKCA(5), PRKCG(2), RAF1(1), TCF7L2(4), TYR(4), TYRP1(4), WNT11(4), WNT16(2), WNT2(3), WNT2B(1), WNT3A(1), WNT5B(1), WNT7A(2), WNT8A(1), WNT8B(1), WNT9A(1), WNT9B(1) 83189038 162 97 160 54 56 12 22 39 31 2 0.254 1.000 1.000 501 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 67 A2M(5), C1QA(2), C1QB(1), C1R(2), C1S(2), C2(5), C3(13), C3AR1(3), C4BPA(6), C4BPB(1), C5(6), C5AR1(1), C6(3), C7(5), C8A(2), C8B(4), CD46(3), CD55(1), CFB(1), CFD(1), CFH(8), CPB2(1), CR1(5), CR2(4), F10(1), F12(1), F13A1(2), F13B(4), F2(3), F2R(2), F5(7), F7(2), F8(18), F9(3), FGA(6), FGB(1), FGG(1), KLKB1(5), KNG1(2), MASP1(2), MBL2(3), PLAT(1), PLG(4), PROS1(1), SERPINA5(1), SERPINC1(1), SERPIND1(1), SERPINE1(2), SERPINF2(1), SERPING1(3), VWF(7) 68950664 170 93 170 51 53 29 21 45 22 0 0.0397 1.000 1.000 502 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY1(2), ADCY2(4), ADCY3(2), ADCY4(5), ADCY5(2), ADCY7(2), ADCY8(1), ADCY9(7), AKAP1(1), AKAP11(2), AKAP12(1), AKAP2(3), AKAP3(2), AKAP4(6), AKAP5(2), AKAP6(9), AKAP7(1), AKAP8(4), AKAP9(10), ARHGEF1(1), CALM3(1), GNA11(1), GNA13(1), GNA14(3), GNA15(1), GNAI2(1), GNAI3(2), GNAL(1), GNAO1(2), GNAZ(1), GNB2(2), GNB3(1), GNB5(1), GNG12(1), ITPR1(4), KCNJ3(1), KRAS(3), NRAS(4), PALM2(1), PDE1A(1), PDE1B(2), PDE1C(5), PDE4A(1), PDE4B(1), PDE4C(1), PDE4D(6), PDE7A(2), PDE7B(2), PDE8A(6), PDE8B(1), PLCB3(4), PPP3CA(1), PPP3CC(1), PRKACG(1), PRKAR1A(2), PRKCA(5), PRKCG(2), PRKCH(3), PRKCI(2), PRKCQ(2), RRAS(1), USP5(1) 89202908 152 90 151 65 42 22 18 37 31 2 0.776 1.000 1.000 503 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADA(1), ADCY1(2), ADCY2(4), ADCY3(2), ADCY4(5), ADCY5(2), ADCY7(2), ADCY8(1), ADK(1), ADSL(4), AK5(2), ALLC(2), AMPD1(5), AMPD2(3), AMPD3(1), ATIC(1), ATP1B1(1), ATP5B(2), ATP5G2(1), CANT1(3), DCK(1), ENPP1(4), ENPP3(2), ENTPD1(3), GART(4), GDA(1), GUCY1A2(2), GUCY1A3(2), GUCY2C(4), GUCY2F(3), HPRT1(1), IMPDH1(3), NPR1(1), NPR2(3), NT5C(3), NT5E(1), NT5M(1), PAICS(2), PDE1A(1), PDE4A(1), PDE4B(1), PDE4C(1), PDE4D(6), PDE5A(1), PDE6B(3), PDE6C(7), PDE7B(2), PDE8A(6), PDE9A(2), PFAS(6), PKLR(3), POLB(3), POLD1(2), POLD2(2), POLE(8), POLG(1), POLL(1), POLQ(4), POLR1B(2), POLR2A(7), POLR2B(3), POLR2C(2), POLR2G(1), POLRMT(1), PPAT(2), PRPS1(1), PRPS1L1(1), PRPS2(3), RRM1(3) 97777520 173 90 173 71 55 35 18 43 22 0 0.621 1.000 1.000 504 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 108 ALG10B(2), ALG12(2), ALG13(4), ALG14(1), ALG3(2), ALG6(3), B3GNT2(1), B3GNT7(1), C1GALT1(1), CHPF(1), CHST1(1), CHST11(3), CHST13(2), CHST3(3), CHST4(1), CHSY1(2), DAD1(1), DPAGT1(2), EXT1(3), EXT2(2), EXTL1(3), EXTL2(2), EXTL3(1), FUT8(6), GALNT1(4), GALNT10(1), GALNT11(2), GALNT12(3), GALNT13(2), GALNT14(4), GALNT2(2), GALNT3(1), GALNT4(3), GALNT5(3), GALNT6(3), GALNT8(1), GALNT9(2), GALNTL5(1), GANAB(4), GCNT3(1), GCNT4(2), HS3ST1(1), HS3ST3A1(1), HS6ST2(4), HS6ST3(1), MAN1A1(2), MAN1A2(1), MAN1B1(1), MAN1C1(2), MAN2A1(4), MGAT1(3), MGAT2(2), MGAT3(3), MGAT4A(1), MGAT5(1), MGAT5B(1), NDST1(2), NDST2(2), NDST3(3), NDST4(2), OGT(8), RPN1(1), RPN2(1), ST3GAL1(2), ST3GAL2(1), ST3GAL3(2), ST3GAL4(3), ST6GAL1(1), ST6GALNAC1(2), STT3B(2), WBSCR17(5), XYLT1(2), XYLT2(1) 84081651 157 88 156 48 51 29 19 36 22 0 0.0951 1.000 1.000 505 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(6), ABCA10(1), ABCA12(4), ABCA13(17), ABCA2(4), ABCA3(4), ABCA4(6), ABCA5(4), ABCA6(6), ABCA7(9), ABCA8(5), ABCA9(3), ABCB1(5), ABCB10(3), ABCB11(1), ABCB4(6), ABCB5(6), ABCB7(5), ABCB8(1), ABCB9(2), ABCC1(5), ABCC10(11), ABCC11(7), ABCC12(4), ABCC2(1), ABCC3(5), ABCC4(4), ABCC5(3), ABCC6(1), ABCC8(6), ABCC9(6), ABCD1(2), ABCD2(1), ABCG1(1), ABCG2(1), ABCG4(3), ABCG5(3), ABCG8(4), CFTR(4), TAP1(1) 89939375 171 79 171 66 46 28 27 49 18 3 0.475 1.000 1.000 506 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 ASH1L(5), ASH2L(2), CTCFL(4), DOT1L(3), EHMT1(5), EHMT2(3), EZH1(2), EZH2(2), FBXO11(2), HCFC1(7), HSF4(2), JMJD4(1), JMJD6(3), KDM6A(3), MEN1(1), NSD1(4), OGT(8), PAXIP1(2), PPP1CA(1), PPP1CB(1), PRDM2(5), PRDM7(1), PRDM9(8), PRMT1(1), PRMT5(4), PRMT6(1), PRMT7(1), PRMT8(4), RBBP5(1), SATB1(3), SETD1A(1), SETD2(12), SETD7(2), SETD8(1), SETDB1(7), SETDB2(1), SETMAR(3), STK38(1), SUV39H1(2), SUV420H1(2), SUZ12(1), WHSC1L1(4) 90481891 127 73 127 30 36 20 20 29 22 0 0.0242 1.000 1.000 507 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(1), BCAR1(3), CAPN10(4), CAPN11(4), CAPN3(3), CAPN5(2), CAPN6(1), CAPN7(1), CAPN9(4), CAPNS1(1), CSK(1), DOCK1(1), FYN(1), ILK(1), ITGA10(4), ITGA11(2), ITGA2(4), ITGA2B(1), ITGA4(5), ITGA5(2), ITGA6(3), ITGA7(2), ITGA8(5), ITGAD(2), ITGAE(6), ITGAL(2), ITGAM(2), ITGAV(2), ITGAX(2), ITGB1(2), ITGB2(1), ITGB3(2), ITGB4(5), ITGB6(7), ITGB7(4), ITGB8(1), MAP2K2(1), MAP2K3(3), MAPK10(1), MAPK12(2), MAPK4(2), MAPK7(5), MYLK2(1), PAK1(2), PAK2(2), PAK3(3), PAK4(1), PAK6(3), PIK3R2(1), PTK2(2), RAC1(1), RAC2(1), RAPGEF1(4), ROCK1(2), ROCK2(4), SDCCAG8(2), SHC1(1), SHC3(1), SORBS1(1), SOS1(4), TLN1(5), TNS1(3), VAV2(2), VAV3(2), VCL(1) 101991591 157 73 157 55 48 22 22 40 25 0 0.316 1.000 1.000 508 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CDC40(2), CLK2(1), CLK3(3), CLK4(2), COL2A1(5), CPSF1(2), CPSF2(2), CPSF3(3), CSTF1(2), CSTF2(3), CSTF3(4), DDIT3(1), DHX15(1), DHX16(4), DHX38(3), DHX8(7), DHX9(2), DICER1(2), FUS(3), METTL3(4), NCBP1(1), NONO(2), PAPOLA(5), PHF5A(2), POLR2A(7), PRPF18(1), PRPF4(1), PRPF4B(3), PRPF8(10), PSKH1(1), PTBP1(2), RNGTT(4), SF3A3(1), SF3B1(7), SF3B2(1), SNRPA(1), SNRPB(1), SNRPB2(1), SNRPD2(1), SNRPD3(1), SNRPE(1), SNURF(2), SPOP(4), SRPK1(1), SRPK2(1), SRRM1(2), SUPT5H(2), TXNL4A(1), U2AF1(3), U2AF2(3), XRN2(3) 80549010 132 72 131 31 40 19 14 39 19 1 0.0654 1.000 1.000 509 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 89 ACVR1(3), ACVR1B(3), ACVR1C(1), ACVR2A(2), ACVRL1(5), AMHR2(1), BMP4(2), BMP5(4), BMP6(2), BMPR1A(1), BMPR1B(1), CHRD(1), COMP(1), CREBBP(9), CUL1(1), DCN(2), E2F5(1), EP300(5), FST(1), GDF5(1), GDF6(1), GDF7(1), INHBB(1), INHBE(2), LEFTY2(2), LTBP1(7), MAPK1(2), MAPK3(1), NODAL(1), PITX2(4), PPP2CA(4), PPP2CB(1), PPP2R1B(1), PPP2R2A(4), PPP2R2C(3), RBL1(4), RBL2(3), RBX1(1), ROCK1(2), ROCK2(4), RPS6KB1(2), RPS6KB2(3), SMAD1(4), SMAD2(3), SMAD3(3), SMAD5(1), SMAD6(1), SMAD7(2), SMAD9(3), SMURF1(2), SMURF2(2), TGFB2(2), TGFB3(1), TGFBR1(2), TGFBR2(3), THBS1(4), THBS2(6), THBS3(4), THBS4(3), TNF(1), ZFYVE16(1), ZFYVE9(1) 75697233 150 70 150 41 45 21 24 39 20 1 0.0311 1.000 1.000 510 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 84 ATF2(2), BRAF(6), CREB1(1), DAXX(2), ELK1(3), FOS(1), IKBKB(1), MAP2K2(1), MAP2K3(3), MAP2K5(2), MAP3K1(3), MAP3K10(1), MAP3K12(5), MAP3K13(2), MAP3K3(2), MAP3K4(4), MAP3K5(3), MAP3K6(1), MAP3K8(4), MAP3K9(3), MAP4K1(1), MAP4K3(2), MAP4K4(2), MAP4K5(1), MAPK1(2), MAPK10(1), MAPK12(2), MAPK13(1), MAPK3(1), MAPK4(2), MAPK7(5), MAPK8(2), MAPK9(1), MAPKAPK2(1), MAPKAPK3(1), MAPKAPK5(2), MAX(4), MEF2A(2), MEF2B(1), MKNK1(2), NFKB1(1), NFKBIA(2), PAK1(2), PAK2(2), RAC1(1), RAF1(1), RELA(1), RIPK1(3), RPS6KA1(4), RPS6KA2(3), RPS6KA3(3), RPS6KA5(1), RPS6KB1(2), RPS6KB2(3), SHC1(1), STAT1(2), TGFB2(2), TGFB3(1), TGFBR1(2), TRADD(1), TRAF2(2) 72344165 126 69 123 43 32 14 22 28 28 2 0.373 1.000 1.000 511 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 53 ADORA3(2), ALG6(3), CCKBR(2), CCR2(2), CCR3(1), CELSR1(9), CELSR2(12), CELSR3(12), CHRM3(3), EDNRA(1), EMR2(5), EMR3(1), F2R(2), FSHR(2), GHRHR(2), GNRHR(2), GPR116(6), GPR132(5), GPR133(4), GPR143(4), GPR17(1), GPR18(2), GPR61(3), GPR84(2), GRM1(4), GRPR(3), HRH4(2), LPHN2(7), LPHN3(5), LTB4R2(1), NTSR1(1), P2RY11(3), P2RY13(1), PTGFR(6), SMO(2), SSTR2(2), TAAR5(1), TSHR(4) 50799301 130 67 129 41 42 27 18 30 13 0 0.0432 1.000 1.000 512 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 82 ANPEP(3), CD14(1), CD19(1), CD1A(3), CD1B(4), CD1E(4), CD22(3), CD33(1), CD36(4), CD3D(1), CD4(1), CD44(3), CD55(1), CD7(1), CR1(5), CR2(4), CSF1R(4), CSF2RA(7), CSF3R(2), DNTT(1), EPO(1), EPOR(1), FCGR1A(1), FLT3(4), GP5(2), GP9(1), HLA-DRA(3), HLA-DRB1(1), HLA-DRB5(1), IL1B(2), IL1R1(2), IL1R2(3), IL3(1), IL3RA(2), IL4R(2), IL5(1), IL5RA(2), IL6(1), IL6R(1), IL7R(1), IL9R(2), ITGA1(2), ITGA2(4), ITGA2B(1), ITGA4(5), ITGA5(2), ITGA6(3), ITGAM(2), ITGB3(2), KIT(6), KITLG(2), MME(2), MS4A1(3), TFRC(2), THPO(1), TNF(1), TPO(6) 62003480 133 67 133 44 34 28 20 35 16 0 0.108 1.000 1.000 513 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 70 ACACB(11), ACSL1(3), ACSL3(2), ACSL4(5), ACSL6(2), ADIPOR1(2), ADIPOR2(3), AGRP(1), AKT1(1), CAMKK1(1), CAMKK2(2), CD36(4), CPT1A(1), CPT1C(1), CPT2(1), G6PC(7), G6PC2(1), IKBKB(1), IRS1(4), IRS2(1), IRS4(5), JAK1(1), JAK2(4), JAK3(3), LEPR(2), MAPK10(1), MAPK8(2), MAPK9(1), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIE(1), NPY(3), PCK1(3), PPARA(3), PPARGC1A(1), PRKAA1(3), PRKAA2(2), PRKAG1(1), PRKAG2(1), PRKCQ(2), PTPN11(7), RELA(1), RXRA(1), RXRG(3), SLC2A1(2), SLC2A4(1), STAT3(2), STK11(1), TNF(1), TNFRSF1B(2), TRADD(1), TRAF2(2), TYK2(7) 63216380 128 64 126 46 36 25 8 38 20 1 0.328 1.000 1.000 514 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 69 ADH1A(1), ADH1B(2), ADH5(1), ADH6(3), ADH7(2), ADHFE1(2), AKR1C1(1), AKR1C2(1), AKR1C3(1), ALDH1A3(4), ALDH3A1(4), ALDH3B2(2), CYP1A2(2), CYP1B1(1), CYP2B6(2), CYP2C18(3), CYP2C19(4), CYP2C8(2), CYP2C9(3), CYP2E1(1), CYP2S1(1), CYP3A4(3), CYP3A7(1), EPHX1(3), GSTA1(1), GSTA2(1), GSTA3(1), GSTA4(1), GSTA5(3), GSTK1(1), GSTM4(1), GSTM5(1), GSTT1(1), GSTZ1(3), UGT1A1(5), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A5(2), UGT1A6(2), UGT1A7(2), UGT2A1(5), UGT2A3(6), UGT2B10(3), UGT2B11(3), UGT2B15(2), UGT2B17(2), UGT2B28(2), UGT2B4(4), UGT2B7(2) 43714439 109 63 108 34 31 14 18 34 12 0 0.202 1.000 1.000 515 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 92 ACTB(2), CABIN1(6), CALM3(1), CAMK4(2), CDKN1A(1), CEBPB(1), CNR1(1), CREBBP(9), CSNK2A1(2), CSNK2B(1), CTLA4(1), EGR3(1), EP300(5), FCER1A(2), FCGR3A(1), FOS(1), GATA3(3), GATA4(1), ICOS(1), IFNB1(1), IL10(1), IL1B(2), IL3(1), IL6(1), ITK(1), KPNA5(3), MAPK8(2), MAPK9(1), MEF2A(2), MEF2B(1), MYF5(4), NFAT5(3), NFATC1(2), NFATC2(5), NFATC3(2), NFATC4(3), NFKB2(1), NFKBIE(1), NUP214(2), OPRD1(1), P2RX7(1), PAK1(2), PPP3CC(1), PTPRC(7), RELA(1), RPL13A(1), SFN(2), SLA(2), SP3(4), TNF(1), TRAF2(2), TRPV6(7), VAV1(5), VAV2(2), VAV3(2), XPO5(1) 69330577 123 60 123 38 31 28 14 30 20 0 0.0982 1.000 1.000 516 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 AICDA(2), CAD(5), CANT1(3), CDA(1), CTPS2(2), DCK(1), DCTD(1), DHODH(2), DPYD(4), DPYS(4), ENTPD1(3), ENTPD5(1), ENTPD6(2), ENTPD8(1), NT5C(3), NT5C1A(1), NT5C1B(5), NT5C2(1), NT5E(1), NT5M(1), POLA1(2), POLA2(1), POLD1(2), POLD2(2), POLD3(2), POLE(8), POLR1A(5), POLR1B(2), POLR2A(7), POLR2B(3), POLR2C(2), POLR2G(1), POLR3A(7), POLR3B(2), POLR3GL(1), POLR3K(1), PRIM1(1), PRIM2(1), RRM1(3), RRM2B(1), TK2(3), TXNRD2(3), UCK1(3), UMPS(1), UPP1(1), UPP2(2), UPRT(2) 61634891 113 60 112 35 24 16 13 39 21 0 0.334 1.000 1.000 517 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ADCY4(5), ADCY8(1), CACNA1A(3), CACNA1B(9), GNAS(4), GNAT3(1), GNB3(1), GRM4(4), ITPR3(13), KCNB1(3), PDE1A(1), PLCB2(4), PRKACG(1), SCNN1B(3), SCNN1G(2), TAS1R2(3), TAS1R3(1), TAS2R1(3), TAS2R10(2), TAS2R13(1), TAS2R16(4), TAS2R3(1), TAS2R38(1), TAS2R4(2), TAS2R40(2), TAS2R41(3), TAS2R42(1), TAS2R46(1), TAS2R5(1), TAS2R7(1), TAS2R9(4), TRPM5(2) 43337612 88 60 88 30 34 15 9 21 9 0 0.266 1.000 1.000 518 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR2(3), ATP8A1(3), AVPR1A(4), AVPR1B(1), AVPR2(3), BRS3(1), C3AR1(3), CCKBR(2), CCR10(1), CCR2(2), CCR3(1), CCR4(1), CCR6(2), CCR7(1), CCR8(1), CX3CR1(1), CXCR4(2), CXCR6(1), EDNRA(1), EDNRB(1), FPR1(1), FSHR(2), GALR1(1), GNB2L1(2), GNRHR(2), GRPR(3), MC1R(3), MC3R(2), MC4R(3), MC5R(3), NMBR(5), NPY1R(3), NPY2R(1), NTSR1(1), OPRD1(1), OPRK1(1), OPRL1(1), OPRM1(2), SSTR2(2), SSTR3(5), SSTR4(8), TACR2(2), TACR3(3), TRHR(2), TSHR(4) 39988057 98 60 98 47 32 12 22 26 6 0 0.769 1.000 1.000 519 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 ACTG1(1), APAF1(3), ARHGDIB(1), BAG4(1), BIRC2(2), CASP2(1), CASP8(2), CFLAR(1), CRADD(1), CYCS(2), DAXX(2), DFFA(2), GSN(1), LMNA(2), LMNB2(2), MAP3K1(3), MAP3K5(3), MAPK8(2), MDM2(3), NFKB1(1), NFKBIA(2), NUMA1(8), PAK2(2), PRKDC(11), PTK2(2), RASA1(4), RB1(6), RELA(1), RIPK1(3), SPTAN1(5), TNF(1), TNFRSF1B(2), TRADD(1), TRAF2(2) 52611772 86 54 86 27 22 14 14 21 14 1 0.308 1.000 1.000 520 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACADL(1), ACADM(2), ACOX1(2), ACOX2(2), ACOX3(3), ACSL1(3), ACSL3(2), ACSL4(5), ACSL6(2), ANGPTL4(1), APOA1(1), AQP7(3), CD36(4), CPT1A(1), CPT1C(1), CPT2(1), CYP27A1(1), CYP4A11(1), CYP4A22(2), CYP7A1(2), CYP8B1(1), DBI(1), EHHADH(1), FABP4(1), FABP6(1), FABP7(1), FADS2(2), GK(1), GK2(4), HMGCS2(3), ILK(1), LPL(2), ME1(1), MMP1(1), NR1H3(5), OLR1(1), PCK1(3), PPARA(3), PPARG(2), RXRA(1), RXRG(3), SCD(1), SCP2(1), SLC27A1(2), SLC27A2(2), SLC27A4(1), SLC27A5(4), SORBS1(1), UBC(5) 49826175 96 52 95 35 22 21 12 27 14 0 0.359 1.000 1.000 521 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 56 BMP4(2), BMP5(4), BMP6(2), BTRC(1), CSNK1A1(2), CSNK1A1L(2), CSNK1D(1), CSNK1E(1), CSNK1G1(1), CSNK1G2(2), GLI1(2), GLI2(2), GLI3(5), HHIP(2), IHH(2), LRP2(22), PRKACG(1), PTCH1(3), RAB23(1), SHH(1), SMO(2), STK36(2), SUFU(3), WNT11(4), WNT16(2), WNT2(3), WNT2B(1), WNT3A(1), WNT5B(1), WNT7A(2), WNT8A(1), WNT8B(1), WNT9A(1), WNT9B(1), ZIC2(1) 46475326 85 48 85 35 32 14 12 16 11 0 0.613 1.000 1.000 522 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(1), ALPP(5), ALPPL2(2), ASCC3(3), ATP13A2(1), DDX19A(2), DDX23(3), DDX4(5), DDX41(2), DDX47(2), DDX51(3), DDX52(2), DDX54(2), DDX55(1), DDX56(3), DHFR(1), DHX58(1), ENTPD7(2), EP400(3), ERCC2(3), ERCC3(2), FPGS(2), GGH(1), IFIH1(3), MOV10L1(3), QDPR(2), RAD54B(3), RAD54L(5), RUVBL2(2), SETX(4), SKIV2L2(3), SMARCA2(2), SMARCA5(2), SPR(1) 47815696 82 47 82 29 26 15 10 16 15 0 0.497 1.000 1.000 523 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AADAT(1), AANAT(1), ACAT2(1), ACMSD(1), AFMID(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH7A1(2), AOX1(5), ASMT(1), CAT(3), CYP1A2(2), CYP1B1(1), DDC(2), ECHS1(2), EHHADH(1), GCDH(1), HADHA(2), HSD17B4(2), KMO(3), KYNU(1), LCMT1(2), LCMT2(1), LNX1(4), MAOA(2), METTL2B(3), METTL6(1), NFX1(2), OGDH(1), OGDHL(4), PRMT2(2), PRMT5(4), PRMT6(1), PRMT7(1), PRMT8(4), TDO2(2), TPH1(3), TPH2(2), WARS2(2), WBSCR22(2) 46158327 89 46 89 31 29 12 12 22 14 0 0.343 1.000 1.000 524 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 AANAT(1), ACAT2(1), ACMSD(1), ALDH1A1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), AOX1(5), ASMT(1), CAT(3), CYP1A2(2), CYP2A13(1), CYP2A7(1), CYP2B6(2), CYP2C18(3), CYP2C19(4), CYP2C8(2), CYP2C9(3), CYP2E1(1), CYP3A4(3), CYP3A7(1), CYP4B1(1), CYP51A1(2), DDC(2), ECHS1(2), EHHADH(1), GCDH(1), HADHA(2), KMO(3), KYNU(1), MAOA(2), SDS(1), TDO2(2), TPH1(3), WARS2(2) 41951055 74 45 74 27 26 11 6 18 13 0 0.481 1.000 1.000 525 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(1), ADCY3(2), ADCY9(7), ARF1(1), ARF6(1), ATP6V0A2(1), ATP6V0C(1), ATP6V0D2(2), ATP6V1A(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1E2(2), ATP6V1G3(2), ATP6V1H(1), ERO1L(1), GNAS(4), PDIA4(3), PLCG1(6), PLCG2(9), PRKCA(5), SEC61A1(1), TRIM23(2) 28202868 55 39 54 22 22 11 6 7 8 1 0.549 1.000 1.000 526 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA2(3), ACADL(1), ACADM(2), ACADS(2), ACADVL(2), ACAT2(1), ACOX1(2), ACOX3(3), ACSL1(3), ACSL3(2), ACSL4(5), ACSL6(2), ADH1A(1), ADH1B(2), ADH5(1), ADH6(3), ADH7(2), ADHFE1(2), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH7A1(2), CPT1A(1), CPT1C(1), CPT2(1), CYP4A11(1), CYP4A22(2), ECHS1(2), EHHADH(1), GCDH(1), HADHA(2), HSD17B4(2) 37314430 68 35 68 30 16 9 7 20 16 0 0.786 1.000 1.000 527 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(2), CCND1(4), CREBBP(9), EP300(5), ERCC3(2), ESR1(2), GRIP1(2), GTF2E1(3), GTF2F1(1), HDAC2(4), HDAC3(1), HDAC4(3), HDAC5(1), HDAC6(3), NCOR2(7), NR0B1(1), NRIP1(2), PELP1(2), POLR2A(7) 35177150 61 34 60 24 22 4 5 16 14 0 0.756 1.000 1.000 528 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AADAT(1), AASDHPPT(1), ACAT2(1), AKR1B10(2), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH7A1(2), DOT1L(3), ECHS1(2), EHHADH(1), EHMT1(5), EHMT2(3), GCDH(1), HADHA(2), HSD17B4(2), HSD3B7(1), NSD1(4), OGDH(1), OGDHL(4), PIPOX(1), PLOD1(3), PLOD2(2), PLOD3(1), SETD1A(1), SETD7(2), SETDB1(7), SHMT1(2), SUV39H1(2), TMLHE(2) 44246315 72 34 72 29 26 7 9 18 12 0 0.578 1.000 1.000 529 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR2(2), ACTR3(1), ARHGAP1(1), ARHGAP4(2), ARHGAP5(2), ARHGAP6(2), ARHGEF1(1), ARHGEF11(2), ARHGEF5(1), ARPC1A(1), ARPC1B(2), ARPC3(1), BAIAP2(3), CFL1(1), DIAPH1(5), GSN(1), LIMK1(4), MYL2(2), MYLK(5), OPHN1(4), PIP5K1B(1), ROCK1(2), TLN1(5), VCL(1) 34569349 52 34 52 20 13 5 7 20 7 0 0.647 1.000 1.000 530 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(1), ALOX12(1), ALOX15(2), ALOX5(1), CBR3(1), CYP4F3(4), EPX(5), GGT1(2), LPO(5), LTA4H(4), MPO(2), PLA2G3(4), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PRDX1(1), PTGES2(1), PTGS1(2), PTGS2(2), TBXAS1(1), TPO(6) 21251572 52 33 52 20 16 13 6 9 7 1 0.331 1.000 1.000 531 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(7), IL6ST(3), MRPL19(2), RPL10(4), RPL13A(1), RPL15(1), RPL18A(1), RPL23(1), RPL24(1), RPL29(1), RPL32(1), RPL35(2), RPL36(1), RPL5(3), RPL6(1), RPL7(2), RPL7A(1), RPS11(1), RPS12(1), RPS18(2), RPS19(1), RPS2(1), RPS24(1), RPS3(3), RPS4X(2), RPS6KA1(4), RPS6KA2(3), RPS6KA3(3), RPS6KA6(3), RPS6KB1(2), RPS6KB2(3), SLC36A2(1), TBC1D10C(1), UBC(5) 39869450 70 33 70 20 15 11 8 23 13 0 0.379 1.000 1.000 532 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(1), ARHGEF11(2), DLG4(3), GNA13(1), LPA(7), MAP3K1(3), MAP3K5(3), MAPK8(2), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIE(1), PDK1(2), PHKA2(5), PI3(2), PIK3CB(3), PLD1(7), PLD3(1), PTK2(2), RDX(5), ROCK1(2), ROCK2(4), SERPINA4(2), SRF(2), TBXA2R(1) 37424850 65 32 65 23 18 10 11 17 8 1 0.478 1.000 1.000 533 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(3), AKT1(1), DAG1(1), ITPR1(4), ITPR2(12), ITPR3(13), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIE(1), PDK1(2), PHKA2(5), PIK3CB(3), PITX2(4), PLD1(7), PLD3(1) 34177495 61 32 61 26 20 8 11 17 3 2 0.652 1.000 1.000 534 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(3), BAX(1), CASP1(4), CASP2(1), CASP4(1), CASP8(2), CD40(1), CD40LG(2), CRADD(1), CYCS(2), DAXX(2), DFFA(2), FAS(1), FASLG(1), IKBKE(5), NFKB1(1), NFKBIA(2), NGFR(1), NR3C1(3), NTRK1(2), PTPN13(3), RIPK1(3), TFG(1), TNF(1), TNFRSF1B(2), TRADD(1), TRAF2(2), TRAF3(1) 33086951 52 31 52 20 16 9 4 12 11 0 0.570 1.000 1.000 535 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 B3GALT1(2), B3GALT2(1), B3GALT5(1), B3GNT2(1), B3GNT3(2), B3GNT4(2), B3GNT5(4), B4GALNT1(2), B4GALT6(1), FUT2(2), FUT5(3), FUT6(2), GBGT1(1), PIGA(3), PIGB(1), PIGC(1), PIGG(1), PIGN(1), PIGO(3), PIGQ(3), PIGS(2), PIGT(1), PIGU(1), PIGX(1), PIGZ(1), ST3GAL1(2), ST3GAL2(1), ST3GAL3(2), ST3GAL4(3), ST3GAL6(3), ST6GALNAC3(2), ST6GALNAC6(1), ST8SIA1(1), ST8SIA5(3), UGCG(2) 37013996 63 31 63 23 23 6 5 19 10 0 0.566 1.000 1.000 536 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT1(1), ANKRD6(2), APC(2), AXIN1(1), AXIN2(1), CSNK1A1(2), CTNNB1(3), DACT1(3), DKK1(1), DKK2(2), DKK4(2), LRP1(20), NKD1(1), NKD2(4), PTPRA(4), SENP2(3), SFRP1(1), WIF1(2) 30710260 55 30 54 21 15 9 5 15 11 0 0.758 1.000 1.000 537 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(2), CAMK2D(1), CAMK2G(2), DAG1(1), ITPR1(4), ITPR2(12), ITPR3(13), NFAT5(3), PDE6A(2), PDE6B(3), PDE6C(7), SLC6A13(2), TF(2) 27295249 54 30 54 22 16 10 10 12 5 1 0.502 1.000 1.000 538 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CD14(1), ELK1(3), FOS(1), IKBKB(1), IRAK1(1), MAP2K3(3), MAP3K1(3), MAPK8(2), NFKB1(1), NFKBIA(2), PPARA(3), RELA(1), TLR10(5), TLR2(1), TLR3(5), TLR4(2), TLR6(3), TLR7(6), TLR9(3), TOLLIP(1) 27835313 48 30 47 19 16 7 8 13 4 0 0.565 1.000 1.000 539 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 ALDH1A1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH4A1(2), ARG2(2), ASL(2), CKM(2), CKMT1A(2), CKMT1B(2), CKMT2(1), CPS1(3), GLUD1(4), GOT1(2), MAOA(2), NOS1(5), NOS3(7), OAT(1), ODC1(3), P4HA1(1), RARS(2), SMS(1) 33655967 58 29 58 25 17 11 6 14 10 0 0.701 1.000 1.000 540 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 AGXT(2), AGXT2(2), ALAS1(1), ALAS2(1), AMT(1), ATP6V0C(1), CBS(4), CHKB(1), CTH(1), DLD(1), DMGDH(1), GARS(3), GCAT(1), GLDC(2), MAOA(2), PISD(1), PLCB2(4), PLCG1(6), PLCG2(9), PSPH(1), SARDH(2), SARS(1), SHMT1(2) 32027069 50 29 49 20 16 15 3 9 7 0 0.379 1.000 1.000 541 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(4), CALCR(1), CD97(2), CRHR2(3), ELTD1(1), EMR1(4), EMR2(5), GHRHR(2), GIPR(2), GLP1R(1), GLP2R(1), GPR64(3), LPHN1(1), LPHN2(7), LPHN3(5), SCTR(1), VIPR1(1), VIPR2(1) 20325843 45 29 45 20 11 8 10 14 2 0 0.748 1.000 1.000 542 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(2), ARG2(2), ASL(2), ASS1(3), CKM(2), CKMT1A(2), CKMT1B(2), CKMT2(1), CPS1(3), EPRS(3), GLUD1(4), GLUD2(1), GOT1(2), LAP3(1), NOS1(5), NOS3(7), OAT(1), P4HA1(1), PARS2(1), RARS(2), RARS2(4) 27330755 51 28 51 22 15 10 5 13 8 0 0.733 1.000 1.000 543 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1D1(1), ARSD(3), ARSE(3), CYP11B1(1), CYP11B2(1), HSD17B8(1), HSD3B1(2), HSD3B2(1), SRD5A1(1), SULT2A1(2), UGT1A1(5), UGT1A10(1), UGT1A3(3), UGT1A4(1), UGT1A5(2), UGT1A6(2), UGT1A7(2), UGT2B15(2), UGT2B4(4) 20847939 38 27 37 15 13 4 9 9 3 0 0.455 1.000 1.000 544 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(1), FUCA1(2), FUCA2(3), GLB1(2), HEXA(1), HEXB(1), LCT(10), MAN2B1(2), MAN2B2(5), MAN2C1(2), MANBA(1), NEU1(1), NEU2(5), NEU3(2) 15530173 38 27 38 17 12 3 6 11 6 0 0.812 1.000 1.000 545 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(2), ANAPC10(1), ANAPC2(2), ANAPC5(4), ANAPC7(1), BTRC(1), CDC16(2), CDC20(1), CDC23(2), CDC27(4), CUL1(1), CUL2(6), CUL3(1), FBXW7(4), FZR1(3), RBX1(1), SKP2(2), SMURF1(2), SMURF2(2), UBE2D4(2), WWP1(3), WWP2(1) 30661395 48 26 48 23 13 7 9 15 4 0 0.920 1.000 1.000 546 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1QA(2), C1QB(1), C1R(2), C1S(2), C2(5), C3(13), C5(6), C6(3), C7(5), C8A(2), C8B(4), MASP1(2) 15822569 47 25 47 21 18 6 3 14 6 0 0.732 1.000 1.000 547 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(6), APOA1(1), APOA4(3), APOE(2), CETP(1), CYP7A1(2), LIPC(1), LPL(2), LRP1(20), SOAT1(2) 20867206 40 25 40 17 10 8 4 14 4 0 0.746 1.000 1.000 548 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCL11(2), CCR3(1), CFL1(1), GNAS(4), LIMK1(4), MAPK1(2), MAPK3(1), MYL2(2), NOX1(1), PIK3C2G(1), PLCB1(3), PRKCA(5), PTK2(2), RAF1(1), ROCK2(4) 19157942 34 24 34 11 6 2 7 11 6 2 0.536 1.000 1.000 549 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(1), ATF1(1), CREB1(1), DUSP1(1), DUSP10(1), EEF2K(2), EIF4E(2), ELK1(3), IL1R1(2), MAP2K3(3), MAP3K10(1), MAP3K4(4), MAP3K5(3), MAPK1(2), MAPK12(2), MAPK13(1), MAPKAPK2(1), MAPKAPK5(2), MKNK1(2), MYEF2(3), NFKB1(1), NR2C2(2), SRF(2) 25383431 43 24 43 20 13 3 10 12 5 0 0.825 1.000 1.000 550 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1QA(2), C1QB(1), C1R(2), C1S(2), C2(5), C3(13), C5(6), C6(3), C7(5), C8A(2) 13311548 41 23 41 16 16 3 3 13 6 0 0.623 1.000 1.000 551 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CALM3(1), CAMK1(1), CAMK1G(1), ELK1(3), FPR1(1), GNA15(1), MAP2K2(1), MAP2K3(3), MAP3K1(3), MAPK1(2), MAPK3(1), NCF1(2), NCF2(3), NFATC1(2), NFATC2(5), NFATC3(2), NFATC4(3), NFKB1(1), NFKBIA(2), PAK1(2), PIK3C2G(1), PLCB1(3), PPP3CA(1), PPP3CC(1), RAC1(1), RAF1(1), RELA(1), SYT1(1) 29198737 50 23 50 21 15 5 6 12 11 1 0.598 1.000 1.000 552 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(2), ADRBK2(5), ARRB2(1), CALM3(1), CALML3(1), CALML6(1), CAMK2A(2), CAMK2D(1), CAMK2G(2), CLCA1(3), CLCA2(4), CLCA4(1), CNGA3(4), CNGA4(1), CNGB1(3), GNAL(1), GUCA1A(1), PDC(1), PDE1C(5), PRKACG(1), PRKG1(1), PRKG2(1) 23256927 43 23 43 19 19 6 2 10 6 0 0.620 1.000 1.000 553 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AADAT(1), AASDH(3), AASDHPPT(1), ACAT2(1), ALDH1A1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ATP6V0C(1), DOT1L(3), ECHS1(2), EHHADH(1), EHMT1(5), EHMT2(3), GCDH(1), HADHA(2), PLOD1(3), PLOD2(2), PLOD3(1), SDS(1), SHMT1(2), TMLHE(2) 28251030 49 23 49 21 18 7 7 9 8 0 0.518 1.000 1.000 554 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(1), CDC7(2), CDK2(1), DIAPH2(2), GMNN(1), MCM10(4), MCM3(1), MCM4(3), MCM5(1), MCM6(3), MCM7(4), NACA(5), POLA2(1), POLD1(2), POLD2(2), POLD3(2), POLE(8), PRIM1(1), RFC1(1), RFC4(3), RPA1(3), UBC(5) 38615485 56 22 56 30 7 6 7 21 15 0 0.977 1.000 1.000 555 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(2), GABBR1(2), GPRC5C(1), GPRC5D(2), GRM1(4), GRM2(4), GRM3(7), GRM4(4), GRM5(4), GRM7(3), GRM8(2) 16034603 35 22 35 18 14 5 2 9 5 0 0.810 1.000 1.000 556 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA2(3), ACAD8(2), ACAD9(1), ADH1A(1), ADH1B(2), ADH5(1), ADH6(3), ADH7(2), ADHFE1(2), AKR1B10(2), AKR1D1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH7A1(2), BAAT(1), CEL(2), CYP27A1(1), CYP7A1(2), HSD3B7(1), LIPA(2), SLC27A5(4), SOAT1(2), SOAT2(1), SRD5A1(1) 24031038 52 22 52 24 13 5 8 21 5 0 0.867 1.000 1.000 557 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(2), AXIN1(1), CREBBP(9), CTNNB1(3), EP300(5), FZD1(2), LDB1(2), LEF1(1), PITX2(4), TRRAP(12) 25291335 41 22 41 16 13 4 6 12 6 0 0.641 1.000 1.000 558 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(3), BIRC2(2), CASP8(2), CFLAR(1), CYCS(2), DFFA(2), GAS2(1), LMNA(2), NFKB1(1), NFKBIA(2), RELA(1), RIPK1(3), SPTAN1(5), TNFRSF25(1), TRADD(1), TRAF2(2) 25444337 31 21 31 11 9 7 3 8 4 0 0.481 1.000 1.000 559 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 AGXT(2), AGXT2(2), AKR1B10(2), ALAS1(1), ALAS2(1), AMT(1), CBS(4), CHKB(1), CTH(1), DLD(1), DMGDH(1), GARS(3), GCAT(1), GLDC(2), HSD3B7(1), MAOA(2), PHGDH(4), PIPOX(1), PISD(1), PSAT1(2), PSPH(1), SARDH(2), SARS(1), SARS2(1), SDS(1), SHMT1(2), TARS2(1) 32498870 43 21 43 17 11 13 4 9 6 0 0.388 1.000 1.000 560 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(2), DARS2(2), EARS2(1), EPRS(3), FARS2(3), GARS(3), HARS(2), HARS2(1), IARS(1), IARS2(3), LARS(4), MARS(5), MARS2(2), MTFMT(1), NARS(1), NARS2(1), PARS2(1), QARS(3), RARS(2), RARS2(4), SARS(1), SARS2(1), TARS2(1), VARS(3), VARS2(1), WARS2(2), YARS(1) 41343983 55 21 55 17 7 14 6 19 9 0 0.455 1.000 1.000 561 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(2), POLA2(1), POLB(3), POLD1(2), POLD2(2), POLD3(2), POLE(8), POLG(1), POLH(1), POLI(3), POLK(2), POLL(1), POLM(3), POLQ(4), PRIM1(1), PRIM2(1), REV1(3), REV3L(7) 30868620 47 21 47 18 11 6 6 15 9 0 0.815 1.000 1.000 562 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA1(2), ANXA2(2), ANXA3(2), ANXA5(1), ANXA6(3), CYP11A1(4), EDNRA(1), EDNRB(1), PLA2G4A(4), PRL(1), PTGER4(1), PTGFR(6), PTGS1(2), PTGS2(2), SCGB1A1(1), TBXAS1(1) 15744427 34 21 34 16 9 3 4 12 6 0 0.837 1.000 1.000 563 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 ATF1(1), CASP2(1), CRADD(1), IKBKB(1), MAP2K3(3), MAP3K1(3), MAPK8(2), NFKB1(1), NFKBIA(2), RELA(1), RIPK1(3), TANK(3), TNF(1), TRADD(1), TRAF2(2) 18386194 26 21 26 11 9 6 2 4 5 0 0.654 1.000 1.000 564 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ALDH1A1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ALDH3B2(2), ASPA(1), CNDP1(2), DDC(2), HAL(1), HARS(2), HDC(2), HNMT(1), MAOA(2), PRPS1(1), PRPS2(3) 18638396 33 20 33 13 15 5 4 7 2 0 0.489 1.000 1.000 565 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 IFNB1(1), IKBKB(1), IL1B(2), IL1R1(2), IL1RAP(1), IL6(1), IRAK1(1), IRAK2(2), IRAK3(6), MAP2K3(3), MAP3K1(3), MAPK8(2), NFKB1(1), NFKBIA(2), RELA(1), TGFB2(2), TGFB3(1), TNF(1), TOLLIP(1) 22587364 34 20 34 12 9 7 6 7 5 0 0.413 1.000 1.000 566 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(1), ACADL(1), ACADM(2), ALDH1A1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), CNDP1(2), DPYD(4), DPYS(4), ECHS1(2), EHHADH(1), GAD1(2), GAD2(1), HADHA(2), MLYCD(3), SDS(1), SMS(1) 22159269 41 19 40 17 12 7 3 11 8 0 0.641 1.000 1.000 567 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA2(3), ADH1A(1), ADH1B(2), ADH6(3), ADH7(2), ADHFE1(2), AKR1D1(1), ALDH1A1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), BAAT(1), CEL(2), CYP27A1(1), CYP7A1(2), SOAT2(1), SRD5A1(1) 17702128 36 19 36 17 10 4 5 13 4 0 0.802 1.000 1.000 568 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CR1(5), CR2(4), HLA-DRA(3), HLA-DRB1(1), ICAM1(2), ITGAL(2), ITGB2(1), PTPRC(7) 11592340 25 19 25 10 8 6 1 6 4 0 0.555 1.000 1.000 569 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(1), F13A1(2), F2(3), F2R(2), FGA(6), FGB(1), FGG(1), PLAT(1), PLG(4), SERPINB2(2), SERPINE1(2) 10221119 25 19 25 10 8 3 3 7 4 0 0.632 1.000 1.000 570 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(3), EXT2(2), EXTL1(3), EXTL2(2), EXTL3(1), HS3ST1(1), HS3ST3A1(1), HS6ST2(4), HS6ST3(1), NDST1(2), NDST2(2), NDST3(3), NDST4(2) 15810266 27 19 27 11 13 1 5 7 1 0 0.648 1.000 1.000 571 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTN1(1), ACTN2(6), BCAR1(3), BCR(3), CAPNS1(1), CAPNS2(1), CRKL(1), CSK(1), FYN(1), ITGA1(2), ITGB1(2), MAP2K2(1), MAPK1(2), MAPK3(1), MAPK8(2), PTK2(2), RAF1(1), ROCK1(2), SHC1(1), SOS1(4), TLN1(5), VCL(1) 35951535 44 19 44 16 15 6 8 9 5 1 0.464 1.000 1.000 572 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CREBBP(9), DUSP1(1), EP300(5), IKBKB(1), IL1B(2), MAP2K3(3), NFKB1(1), NFKBIA(2), NR3C1(3), RELA(1), TGFBR1(2), TGFBR2(3), TLR2(1), TNF(1) 22636812 35 19 35 14 9 6 4 11 5 0 0.673 1.000 1.000 573 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(2), GTF2E1(3), GTF2F1(1), HDAC3(1), NCOA1(2), NCOA2(2), NCOA3(4), NCOR2(7), POLR2A(7), RXRA(1) 18996749 30 19 29 21 5 6 1 11 7 0 0.992 1.000 1.000 574 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(13), C5(6), C6(3), C7(5), C8A(2) 9566157 29 18 29 13 11 2 3 8 5 0 0.728 1.000 1.000 575 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(2), ELK1(3), FOS(1), IL2RB(2), JAK1(1), JAK3(3), LCK(1), MAPK3(1), MAPK8(2), RAF1(1), SHC1(1), SOS1(4), STAT5A(1), STAT5B(2) 17782970 25 18 25 10 4 6 2 7 5 1 0.526 1.000 1.000 576 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 CCNH(2), ERCC3(2), GTF2A2(1), GTF2E1(3), GTF2H1(1), GTF2H4(1), ILK(1), POLR1A(5), POLR1B(2), POLR2A(7), POLR2B(3), POLR2C(2), POLR2G(1), POLR3B(2), POLR3D(1), POLR3E(1), POLR3K(1), TAF9(2) 26732547 38 18 38 24 10 6 4 14 4 0 0.982 1.000 1.000 577 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(3), CD33(1), CD7(1), IFNB1(1), IL10(1), IL12B(2), IL3(1), IL5(1), ITGAX(2), TLR2(1), TLR4(2), TLR7(6), TLR9(3) 14182948 25 17 24 15 6 2 4 10 3 0 0.949 1.000 1.000 578 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 AMT(1), ASNS(2), CA1(1), CA12(2), CA13(1), CA14(1), CA2(1), CA5A(1), CPS1(3), CTH(1), GLS(2), GLS2(1), GLUD1(4), GLUD2(1), GLUL(1), HAL(1) 16202851 24 17 24 14 6 5 1 8 4 0 0.938 1.000 1.000 579 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(5), POLR1B(2), POLR2A(7), POLR2B(3), POLR2C(2), POLR2G(1), POLR3A(7), POLR3B(2), POLR3GL(1), POLR3K(1) 17895966 31 17 31 13 8 3 5 11 4 0 0.727 1.000 1.000 580 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 IKBKB(1), IL1R1(2), IRAK1(1), MAP3K1(3), NFKB1(1), NFKBIA(2), RELA(1), RIPK1(3), TLR4(2), TNF(1), TNFAIP3(2), TNFRSF1B(2), TRADD(1) 18554607 22 17 22 14 11 3 2 2 4 0 0.919 1.000 1.000 581 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCR2(2), CCR3(1), CCR4(1), CCR7(1), CD28(1), CD4(1), CXCR4(2), IFNGR2(1), IL12B(2), IL12RB1(2), IL12RB2(2), IL18R1(2), IL4R(2), IL5(1), TGFB2(2), TGFB3(1) 15230009 24 17 24 16 6 3 4 9 2 0 0.958 1.000 1.000 582 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BAG4(1), BIRC2(2), CASP8(2), CFLAR(1), MAP3K3(2), NFKB1(1), NFKB2(1), NFKBIA(2), NFKBIE(1), NR2C2(2), RALBP1(2), RIPK1(3), TNF(1), TNFAIP3(2), TNFRSF1B(2), TRADD(1), TRAF2(2) 20739828 28 17 28 11 12 5 2 4 5 0 0.609 1.000 1.000 583 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 DUSP1(1), IKBKAP(1), IKBKB(1), MAP3K1(3), NFKB1(1), NFKBIA(2), RELA(1), RIPK1(3), TANK(3), TNFAIP3(2), TNFRSF1B(2), TRAF2(2), TRAF3(1) 17107871 23 17 23 10 11 3 1 3 5 0 0.636 1.000 1.000 584 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1R(4), E2F1(1), ETS1(3), ETV3(1), FOS(1), HDAC2(4), HDAC5(1), NCOR2(7), RBL1(4), RBL2(3), SIN3A(3), SIN3B(1) 19780306 33 16 33 13 7 5 4 7 10 0 0.680 1.000 1.000 585 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT2(1), B3GNT7(1), CHST1(1), CHST4(1), FUT8(6), ST3GAL1(2), ST3GAL2(1), ST3GAL3(2), ST3GAL4(3) 9512730 18 16 18 10 6 3 4 3 2 0 0.828 1.000 1.000 586 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(1), ASNS(2), CA1(1), CA12(2), CA14(1), CA2(1), CA5A(1), CPS1(3), CTH(1), GLS(2), GLS2(1), GLUD1(4), GLUL(1), HAL(1) 14500153 22 16 22 10 6 4 1 7 4 0 0.795 1.000 1.000 587 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(1), AP2A1(1), AP2M1(1), ARF1(1), BTK(2), EEA1(3), GRASP(1), PFKL(4), PFKP(1), PLCG1(6), RAC1(1), RPS6KB1(2), VAV2(2) 18970402 26 16 25 15 7 6 3 5 5 0 0.879 1.000 1.000 588 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CREBBP(9), EP300(5), HDAC3(1), IKBKB(1), NFKB1(1), NFKBIA(2), RELA(1), RIPK1(3), TNF(1), TNFRSF1B(2), TRADD(1) 17058765 27 15 27 11 9 3 1 8 6 0 0.690 1.000 1.000 589 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CREB1(1), CREBBP(9), EP300(5), NCOA3(4), PRKACG(1), PRKAR1A(2), RXRA(1) 15783936 23 14 23 10 7 3 1 8 4 0 0.794 1.000 1.000 590 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(1), CYP51A1(2), DHCR24(2), DHCR7(3), FDFT1(1), FDPS(1), GGCX(1), GGPS1(1), HSD17B7(2), IDI1(2), LSS(1), MVD(3), NQO1(1), NSDHL(2), SQLE(1) 14660783 24 14 23 11 7 3 5 6 3 0 0.804 1.000 1.000 591 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOA(1), ALDOB(1), FBP1(1), FBP2(1), G6PD(2), GPI(2), H6PD(3), PFKP(1), PGD(1), PGM3(1), PRPS1(1), PRPS1L1(1), PRPS2(3), RBKS(1), RPIA(1), TAL1(1), TALDO1(2), TKT(2) 15570476 26 14 26 11 10 7 0 3 6 0 0.420 1.000 1.000 592 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 B3GNT2(1), B3GNT3(2), B3GNT4(2), B3GNT5(4), FUT2(2), FUT5(3), FUT6(2), ST3GAL6(3), ST8SIA1(1) 12357989 20 13 20 11 6 2 2 6 4 0 0.918 1.000 1.000 593 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(2), PLCG1(6), PRKCA(5), PTK2B(2) 5139223 15 13 14 10 4 3 2 4 1 1 0.904 1.000 1.000 594 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(2), ARHGEF1(1), GNA13(1), MYL2(2), MYLK(5), PLCB1(3), PRKCA(5), ROCK1(2) 15731746 21 13 21 12 8 2 4 5 1 1 0.861 1.000 1.000 595 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX12(1), ALOX15(2), ALOX5(1), ALOX5AP(1), GGT1(2), LTA4H(4), PLA2G6(2), PTGES(1), PTGS1(2), PTGS2(2), TBXAS1(1) 11459224 19 12 19 11 5 6 2 2 4 0 0.869 1.000 1.000 596 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 BNIP1(1), GOSR2(1), SNAP29(1), STX11(2), STX16(1), TSNARE1(2), USE1(2), VAMP4(1), VAMP5(2), VAMP8(1), VTI1A(2) 12713081 16 12 15 10 7 3 3 1 2 0 0.870 1.000 1.000 597 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL22RA1(1), JAK1(1), JAK2(4), JAK3(3), STAT1(2), STAT3(2), STAT5A(1), STAT5B(2), TYK2(7) 14030163 23 12 23 10 6 0 2 10 4 1 0.814 1.000 1.000 598 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(1), ALDH1A3(4), ALDH1B1(4), ALDH2(1), ALDH3A1(4), ECHS1(2), EHHADH(1), HADHA(2), SDS(1) 9265337 20 12 20 11 8 2 3 3 4 0 0.782 1.000 1.000 599 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(4), DHFR(1), HPRT1(1), IMPDH1(3), OAZ1(1), POLB(3), POLD1(2), POLG(1), PRPS2(3), RRM1(3), SRM(2) 9483692 24 12 24 10 8 5 5 4 2 0 0.540 1.000 1.000 600 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACOX1(2), ACOX3(3), ELOVL2(1), ELOVL6(1), FADS2(2), FASN(3), HADHA(2), PECR(2), SCD(1) 10908483 17 11 17 15 3 3 2 7 2 0 0.990 1.000 1.000 601 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 BGN(3), DCN(2), FMOD(1), KERA(4), LUM(2) 2766981 12 11 12 6 1 2 3 6 0 0 0.809 1.000 1.000 602 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD28(1), CD3D(1), ICAM1(2), ITGAL(2), ITGB2(1), PTPRC(7) 8208258 14 11 14 10 6 4 0 3 1 0 0.901 1.000 1.000 603 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD28(1), CD3D(1), CD4(1), ICAM1(2), ITGAL(2), ITGB2(1), PTPRC(7) 8611085 15 11 15 10 6 4 0 4 1 0 0.889 1.000 1.000 604 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(3), POLD1(2), POLD2(2), POLE(8), POLG(1), POLL(1), POLQ(4) 12687575 21 9 21 12 7 3 2 8 1 0 0.920 1.000 1.000 605 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 FYN(1), RELN(12), VLDLR(2) 10689186 15 8 15 10 6 5 1 2 1 0 0.866 1.000 1.000 606 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 LPL(2), NR3C1(3), PPARG(2), RXRA(1), TNF(1) 4434246 9 8 9 5 1 3 1 4 0 0 0.750 1.000 1.000 607 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 C9orf47(1), CNR1(1), CNR2(2), DNMT1(3), MTNR1A(2), MTNR1B(1), PTAFR(1), PTGER4(1), PTGFR(6), TBXA2R(1) 8495625 19 7 19 10 6 3 0 9 1 0 0.808 1.000 1.000 608 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 CDC34(2), NRF1(1), UBE2G2(1), UBE2L6(1), UBE2M(1) 8029378 6 6 6 10 4 0 1 0 1 0 0.999 1.000 1.000 609 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(1), ADH1B(2), ADH6(3), ADH7(2), ADHFE1(2) 4303186 10 5 10 6 1 1 1 7 0 0 0.910 1.000 1.000 610 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(2), EIF2AK4(2), EIF2S2(1), PPP1CA(1) 8807549 6 4 6 7 1 1 2 2 0 0 0.987 1.000 1.000 611 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA3(2), LTB4R(1), P2RY1(1), P2RY2(2), P2RY6(2) 4553771 8 3 8 6 4 2 0 2 0 0 0.902 1.000 1.000 612 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(1), DAG1(1) 4638088 2 2 2 3 0 0 2 0 0 0 0.968 1.000 1.000 613 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 548681 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 614 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 388742 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 615 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 1167814 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 616 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 1307056 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000