Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Glypican 2 network	193.0	773.0	4.0	-0.199	-0.127	1000.0	-1000.0	-0.027	-1000.0
Angiopoietin receptor Tie2-mediated signaling	153.0	13499.0	88.0	-0.623	0.061	1000.0	-1000.0	-0.09	-1000.0
Aurora B signaling	127.0	8518.0	67.0	-0.4	0.01	1000.0	-1000.0	-0.059	-1000.0
FOXM1 transcription factor network	125.0	6395.0	51.0	-0.548	0.01	1000.0	-1000.0	-0.202	-1000.0
Signaling events mediated by the Hedgehog family	103.0	5401.0	52.0	-0.37	0.177	1000.0	-1000.0	-0.071	-1000.0
Aurora C signaling	77.0	544.0	7.0	-0.259	0.004	1000.0	-1000.0	-0.033	-1000.0
Endothelins	74.0	7126.0	96.0	-0.299	0.025	1000.0	-1000.0	-0.073	-1000.0
HIF-1-alpha transcription factor network	70.0	5331.0	76.0	-0.476	0.016	1000.0	-1000.0	-0.157	-1000.0
Visual signal transduction: Cones	68.0	2590.0	38.0	-0.169	0.01	1000.0	-1000.0	-0.054	-1000.0
PLK1 signaling events	68.0	5820.0	85.0	-0.293	0.057	1000.0	-1000.0	-0.041	-1000.0
Signaling events regulated by Ret tyrosine kinase	59.0	4888.0	82.0	-0.157	0.01	1000.0	-1000.0	-0.073	-1000.0
IL4-mediated signaling events	56.0	5125.0	91.0	-0.78	0.511	1000.0	-1000.0	-0.181	-1000.0
Fc-epsilon receptor I signaling in mast cells	53.0	5187.0	97.0	-0.151	0.028	1000.0	-1000.0	-0.072	-1000.0
amb2 Integrin signaling	52.0	4286.0	82.0	-0.46	0.01	1000.0	-1000.0	-0.073	-1000.0
Signaling mediated by p38-alpha and p38-beta	52.0	2303.0	44.0	-0.115	0.01	1000.0	-1000.0	-0.047	-1000.0
BMP receptor signaling	51.0	4175.0	81.0	-0.341	0.027	1000.0	-1000.0	-0.075	-1000.0
FOXA2 and FOXA3 transcription factor networks	49.0	2266.0	46.0	-0.5	0.015	1000.0	-1000.0	-0.094	-1000.0
TCGA08_retinoblastoma	48.0	389.0	8.0	-0.149	0.049	1000.0	-1000.0	-0.017	-1000.0
Osteopontin-mediated events	47.0	1792.0	38.0	-0.348	0.011	1000.0	-1000.0	-0.087	-1000.0
Glucocorticoid receptor regulatory network	45.0	5139.0	114.0	-0.411	0.245	1000.0	-1000.0	-0.072	-1000.0
Visual signal transduction: Rods	45.0	2355.0	52.0	-0.149	0.01	1000.0	-1000.0	-0.066	-1000.0
Syndecan-1-mediated signaling events	44.0	1509.0	34.0	-0.334	0.01	1000.0	-1000.0	-0.053	-1000.0
TCGA08_p53	44.0	308.0	7.0	-0.102	0.052	1000.0	-1000.0	-0.018	-1000.0
LPA4-mediated signaling events	38.0	457.0	12.0	-0.115	0.012	1000.0	-1000.0	-0.018	-1000.0
Arf6 signaling events	38.0	2373.0	62.0	-0.189	0.012	1000.0	-1000.0	-0.056	-1000.0
p75(NTR)-mediated signaling	38.0	4774.0	125.0	-0.295	0.018	1000.0	-1000.0	-0.085	-1000.0
Canonical Wnt signaling pathway	37.0	1919.0	51.0	-0.342	0.147	1000.0	-1000.0	-0.053	-1000.0
Thromboxane A2 receptor signaling	36.0	3851.0	105.0	-0.09	0.028	1000.0	-1000.0	-0.061	-1000.0
Glypican 1 network	36.0	1749.0	48.0	-0.124	0.017	1000.0	-1000.0	-0.045	-1000.0
Effects of Botulinum toxin	34.0	901.0	26.0	-0.089	0.01	1000.0	-1000.0	-0.054	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	34.0	4100.0	120.0	-0.257	0.198	1000.0	-1000.0	-0.062	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	33.0	1746.0	52.0	-0.252	0.042	1000.0	-1000.0	-0.046	-1000.0
Integrins in angiogenesis	33.0	2774.0	84.0	-0.351	0.024	1000.0	-1000.0	-0.08	-1000.0
Ephrin B reverse signaling	32.0	1574.0	48.0	-0.095	0.054	1000.0	-1000.0	-0.065	-1000.0
EGFR-dependent Endothelin signaling events	32.0	682.0	21.0	-0.09	0.01	1000.0	-1000.0	-0.06	-1000.0
ErbB4 signaling events	31.0	2152.0	69.0	-0.191	0.207	1000.0	-1000.0	-0.074	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	30.0	2095.0	68.0	-0.146	0.036	1000.0	-1000.0	-0.119	-1000.0
IL23-mediated signaling events	30.0	1854.0	60.0	-0.284	0.015	1000.0	-1000.0	-0.161	-1000.0
Aurora A signaling	28.0	1710.0	60.0	-0.289	0.015	1000.0	-1000.0	-0.051	-1000.0
Syndecan-3-mediated signaling events	28.0	1001.0	35.0	-0.208	0.01	1000.0	-1000.0	-0.053	-1000.0
IL6-mediated signaling events	28.0	2173.0	75.0	-0.332	0.041	1000.0	-1000.0	-0.085	-1000.0
Presenilin action in Notch and Wnt signaling	27.0	1683.0	61.0	-0.343	0.02	1000.0	-1000.0	-0.067	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	25.0	839.0	33.0	-0.143	0.024	1000.0	-1000.0	-0.046	-1000.0
Reelin signaling pathway	24.0	1345.0	56.0	-0.096	0.01	1000.0	-1000.0	-0.063	-1000.0
Nongenotropic Androgen signaling	24.0	1250.0	52.0	-0.062	0.01	1000.0	-1000.0	-0.049	-1000.0
PDGFR-alpha signaling pathway	23.0	1023.0	44.0	-0.313	0.027	1000.0	-1000.0	-0.052	-1000.0
Class IB PI3K non-lipid kinase events	22.0	66.0	3.0	-0.012	-1000.0	1000.0	-1000.0	-0.011	-1000.0
Wnt signaling	21.0	150.0	7.0	-0.057	0.009	1000.0	-1000.0	-0.028	-1000.0
HIF-2-alpha transcription factor network	20.0	867.0	43.0	-0.121	0.046	1000.0	-1000.0	-0.09	-1000.0
Regulation of Androgen receptor activity	20.0	1425.0	70.0	-0.255	0.026	1000.0	-1000.0	-0.06	-1000.0
Syndecan-2-mediated signaling events	19.0	1316.0	69.0	-0.097	0.031	1000.0	-1000.0	-0.051	-1000.0
Coregulation of Androgen receptor activity	18.0	1391.0	76.0	-0.143	0.018	1000.0	-1000.0	-0.042	-1000.0
PLK2 and PLK4 events	18.0	56.0	3.0	-0.017	-0.003	1000.0	-1000.0	-0.02	-1000.0
Nectin adhesion pathway	18.0	1145.0	63.0	-0.045	0.01	1000.0	-1000.0	-0.06	-1000.0
Syndecan-4-mediated signaling events	18.0	1248.0	67.0	-0.165	0.016	1000.0	-1000.0	-0.076	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	16.0	875.0	54.0	-0.133	0.021	1000.0	-1000.0	-0.081	-1000.0
IL1-mediated signaling events	15.0	969.0	62.0	-0.147	0.048	1000.0	-1000.0	-0.072	-1000.0
FAS signaling pathway (CD95)	15.0	726.0	47.0	-0.25	0.011	1000.0	-1000.0	-0.037	-1000.0
LPA receptor mediated events	15.0	1578.0	102.0	-0.125	0.03	1000.0	-1000.0	-0.073	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	15.0	1207.0	78.0	-0.042	0.036	1000.0	-1000.0	-0.072	-1000.0
Caspase cascade in apoptosis	14.0	1037.0	74.0	-0.038	0.031	1000.0	-1000.0	-0.05	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	14.0	497.0	34.0	-0.041	0.01	1000.0	-1000.0	-0.05	-1000.0
IL12-mediated signaling events	14.0	1276.0	87.0	-0.095	0.039	1000.0	-1000.0	-0.127	-1000.0
Noncanonical Wnt signaling pathway	14.0	387.0	26.0	-0.057	0.01	1000.0	-1000.0	-0.074	-1000.0
Signaling events mediated by PTP1B	14.0	1109.0	76.0	-0.092	0.016	1000.0	-1000.0	-0.068	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	14.0	1763.0	125.0	-0.313	0.034	1000.0	-1000.0	-0.087	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	13.0	1156.0	85.0	-0.045	0.029	1000.0	-1000.0	-0.06	-1000.0
Signaling events mediated by HDAC Class III	13.0	548.0	40.0	-0.116	0.018	1000.0	-1000.0	-0.032	-1000.0
S1P1 pathway	13.0	470.0	36.0	-0.058	0.012	1000.0	-1000.0	-0.051	-1000.0
EPHB forward signaling	13.0	1117.0	85.0	-0.066	0.049	1000.0	-1000.0	-0.079	-1000.0
Signaling events mediated by PRL	13.0	443.0	34.0	-0.181	0.022	1000.0	-1000.0	-0.033	-1000.0
BARD1 signaling events	11.0	683.0	57.0	-0.181	0.03	1000.0	-1000.0	-0.051	-1000.0
Ephrin A  reverse signaling	11.0	82.0	7.0	-0.01	0.008	1000.0	-1000.0	-0.026	-1000.0
S1P5 pathway	11.0	200.0	17.0	-0.031	0.029	1000.0	-1000.0	-0.047	-1000.0
TCR signaling in naïve CD8+ T cells	11.0	1102.0	93.0	-0.072	0.041	1000.0	-1000.0	-0.071	-1000.0
Calcium signaling in the CD4+ TCR pathway	11.0	351.0	31.0	-0.1	0.012	1000.0	-1000.0	-0.078	-1000.0
BCR signaling pathway	11.0	1145.0	99.0	-0.136	0.025	1000.0	-1000.0	-0.076	-1000.0
ErbB2/ErbB3 signaling events	10.0	668.0	65.0	-0.1	0.02	1000.0	-1000.0	-0.062	-1000.0
Regulation of p38-alpha and p38-beta	10.0	565.0	54.0	-0.08	0.017	1000.0	-1000.0	-0.055	-1000.0
S1P4 pathway	10.0	258.0	25.0	-0.031	0.011	1000.0	-1000.0	-0.045	-1000.0
IL2 signaling events mediated by STAT5	9.0	206.0	22.0	-0.11	0.054	1000.0	-1000.0	-0.052	-1000.0
Regulation of nuclear SMAD2/3 signaling	8.0	1199.0	136.0	-0.104	0.054	1000.0	-1000.0	-0.069	-1000.0
Plasma membrane estrogen receptor signaling	8.0	764.0	86.0	-0.036	0.03	1000.0	-1000.0	-0.07	-1000.0
IL27-mediated signaling events	7.0	386.0	51.0	-0.109	0.011	1000.0	-1000.0	-0.072	-1000.0
Regulation of Telomerase	7.0	775.0	102.0	-0.092	0.03	1000.0	-1000.0	-0.082	-1000.0
Ras signaling in the CD4+ TCR pathway	7.0	129.0	17.0	-0.014	0.023	1000.0	-1000.0	-0.037	-1000.0
Sphingosine 1-phosphate (S1P) pathway	6.0	184.0	28.0	-0.031	0.021	1000.0	-1000.0	-0.052	-1000.0
Cellular roles of Anthrax toxin	6.0	235.0	39.0	-0.046	0.015	1000.0	-1000.0	-0.025	-1000.0
Hedgehog signaling events mediated by Gli proteins	6.0	434.0	65.0	-0.176	0.053	1000.0	-1000.0	-0.06	-1000.0
Signaling mediated by p38-gamma and p38-delta	6.0	94.0	15.0	-0.0	0.022	1000.0	-1000.0	-0.031	-1000.0
Retinoic acid receptors-mediated signaling	6.0	383.0	58.0	-0.169	0.031	1000.0	-1000.0	-0.061	-1000.0
Arf6 trafficking events	6.0	475.0	71.0	-0.081	0.034	1000.0	-1000.0	-0.066	-1000.0
Insulin Pathway	6.0	489.0	74.0	-0.152	0.029	1000.0	-1000.0	-0.072	-1000.0
VEGFR1 specific signals	6.0	388.0	56.0	-0.313	0.043	1000.0	-1000.0	-0.065	-1000.0
p38 MAPK signaling pathway	6.0	298.0	44.0	-0.08	0.026	1000.0	-1000.0	-0.061	-1000.0
Signaling events mediated by HDAC Class II	5.0	410.0	75.0	-0.044	0.027	1000.0	-1000.0	-0.053	-1000.0
JNK signaling in the CD4+ TCR pathway	5.0	93.0	17.0	-0.013	0.031	1000.0	-1000.0	-0.059	-1000.0
Ceramide signaling pathway	5.0	403.0	76.0	-0.09	0.036	1000.0	-1000.0	-0.058	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	5.0	453.0	83.0	-0.063	0.039	1000.0	-1000.0	-0.07	-1000.0
FoxO family signaling	5.0	323.0	64.0	-0.12	0.055	1000.0	-1000.0	-0.076	-1000.0
IL2 signaling events mediated by PI3K	5.0	293.0	58.0	-0.149	0.065	1000.0	-1000.0	-0.069	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	5.0	411.0	74.0	-0.113	0.059	1000.0	-1000.0	-0.076	-1000.0
Class I PI3K signaling events	5.0	418.0	73.0	-0.08	0.022	1000.0	-1000.0	-0.06	-1000.0
IFN-gamma pathway	4.0	337.0	68.0	-0.08	0.046	1000.0	-1000.0	-0.088	-1000.0
Signaling events mediated by HDAC Class I	4.0	516.0	104.0	-0.049	0.043	1000.0	-1000.0	-0.052	-1000.0
TCGA08_rtk_signaling	4.0	111.0	26.0	-0.024	0.036	1000.0	-1000.0	-0.021	-1000.0
Circadian rhythm pathway	3.0	73.0	22.0	-0.026	0.034	1000.0	-1000.0	-0.071	-1000.0
Arf6 downstream pathway	3.0	168.0	43.0	-0.036	0.025	1000.0	-1000.0	-0.032	-1000.0
TRAIL signaling pathway	3.0	149.0	48.0	-0.009	0.039	1000.0	-1000.0	-0.057	-1000.0
IGF1 pathway	3.0	225.0	57.0	-0.037	0.04	1000.0	-1000.0	-0.075	-1000.0
S1P3 pathway	3.0	155.0	42.0	-0.03	0.021	1000.0	-1000.0	-0.054	-1000.0
Rapid glucocorticoid signaling	3.0	63.0	20.0	-0.007	0.01	1000.0	-1000.0	-0.034	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	2.0	119.0	45.0	-0.011	0.06	1000.0	-1000.0	-0.081	-1000.0
E-cadherin signaling in the nascent adherens junction	2.0	183.0	76.0	-0.037	0.049	1000.0	-1000.0	-0.069	-1000.0
PDGFR-beta signaling pathway	2.0	227.0	97.0	-0.036	0.048	1000.0	-1000.0	-0.073	-1000.0
Canonical NF-kappaB pathway	1.0	44.0	39.0	-0.013	0.066	1000.0	-1000.0	-0.07	-1000.0
a4b1 and a4b7 Integrin signaling	1.0	8.0	5.0	-0.002	0.009	1000.0	-1000.0	-0.038	-1000.0
EPO signaling pathway	1.0	89.0	55.0	-0.005	0.058	1000.0	-1000.0	-0.075	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	1.0	41.0	37.0	-0.005	0.037	1000.0	-1000.0	-0.052	-1000.0
ceramide signaling pathway	1.0	57.0	49.0	-0.011	0.039	1000.0	-1000.0	-0.042	-1000.0
E-cadherin signaling events	1.0	8.0	5.0	-0.002	0.01	1000.0	-1000.0	-0.034	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	12.0	23.0	-0.003	0.036	1000.0	-1000.0	-0.059	-1000.0
Insulin-mediated glucose transport	0.0	25.0	32.0	-0.003	0.034	1000.0	-1000.0	-0.064	-1000.0
mTOR signaling pathway	0.0	17.0	53.0	-0.001	0.026	1000.0	-1000.0	-0.048	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	29.0	68.0	-0.033	0.045	1000.0	-1000.0	-0.05	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	19.0	36.0	-0.003	0.018	1000.0	-1000.0	-0.062	-1000.0
Atypical NF-kappaB pathway	0.0	17.0	31.0	-0.002	0.038	1000.0	-1000.0	-0.052	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	11.0	27.0	-0.001	0.023	1000.0	-1000.0	-0.043	-1000.0
E-cadherin signaling in keratinocytes	0.0	29.0	43.0	-0.007	0.037	1000.0	-1000.0	-0.056	-1000.0
Arf1 pathway	0.0	20.0	54.0	-0.006	0.024	1000.0	-1000.0	-0.042	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	0.0	0.01	1000.0	-1000.0	-0.052	-1000.0
Total	3099	179615	7203	-18.4467508443	-995.257982277	131000	-131000	-8.17679380789	-131000