rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	21	ATM(53), ATR(26), BRCA1(22), BRCA2(31), CHEK1(7), CHEK2(10), FANCA(7), FANCC(2), FANCD2(4), FANCE(3), FANCF(4), FANCG(7), HUS1(4), MRE11A(13), RAD1(1), RAD17(6), RAD50(10), RAD51(2), RAD9A(2), TP53(309), TREX1(1)	35575939	524	354	387	37	58	144	83	68	166	5	<1.00e-15	<1.00e-15	<1.37e-13
2	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	7	ATM(53), ATR(26), CDC25C(8), CHEK1(7), CHEK2(10), TP53(309), YWHAH(1)	12948811	414	334	278	13	51	105	51	52	150	5	<1.00e-15	<1.00e-15	<1.37e-13
3	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	15	ARF1(1), ARF3(1), CCND1(3), CDK2(1), CDK4(3), CDKN1A(2), CDKN1B(5), CDKN2A(22), E2F1(3), E2F2(5), MDM2(5), NXT1(2), PRB1(5), TP53(309)	6739941	367	307	228	15	50	100	42	38	134	3	<1.00e-15	<1.00e-15	<1.37e-13
4	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	7	HDAC1(4), MAX(8), MYC(4), SP1(6), SP3(6), TP53(309), WT1(16)	5699587	353	306	218	16	48	95	38	36	133	3	<1.00e-15	<1.00e-15	<1.37e-13
5	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	13	CREBBP(30), DAXX(8), HRAS(2), PAX3(10), PML(12), RARA(7), RB1(33), SIRT1(2), SP100(18), TNF(2), TNFRSF1B(2), TP53(309)	15237396	435	318	300	22	58	112	60	42	160	3	<1.00e-15	1.33e-15	1.37e-13
6	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	15	AKT1(3), BCL2(5), EGFR(86), IGF1R(8), MYC(4), POLR2A(11), PPP2CA(1), PRKCA(10), RB1(33), TEP1(39), TERF1(4), TERT(7), TNKS(11), TP53(309), XRCC5(9)	22681635	540	351	356	50	62	137	64	70	204	3	<1.00e-15	1.44e-15	1.37e-13
7	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	12	ATM(53), CDC25A(4), CDC25B(1), CDC25C(8), CDK2(1), CDK4(3), CHEK1(7), MYT1(24), RB1(33), TP53(309), WEE1(4), YWHAH(1)	14151904	448	341	310	18	54	107	51	50	181	5	<1.00e-15	1.55e-15	1.37e-13
8	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	25	ABL1(9), ATM(53), ATR(26), CCNA1(7), CCND1(3), CCNE1(7), CDC25A(4), CDK2(1), CDK4(3), CDK6(5), CDKN1A(2), CDKN1B(5), CDKN2A(22), DHFR(2), E2F1(3), GSK3B(4), HDAC1(4), RB1(33), SKP2(3), TFDP1(10), TGFB1(3), TGFB2(10), TP53(309)	24262756	528	351	385	42	63	138	71	57	194	5	<1.00e-15	2.55e-15	1.75e-13
9	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	9	CHUK(7), DNAJC3(5), EIF2S2(3), NFKB1(6), NFKBIA(4), RELA(3), TP53(309)	7863806	337	303	203	17	43	87	37	38	129	3	<1.00e-15	2.55e-15	1.75e-13
10	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	16	ABL1(9), CDKN2A(22), E2F1(3), MDM2(5), MYC(4), PIK3CA(30), PIK3R1(4), POLR1A(13), POLR1B(11), POLR1D(2), RB1(33), TBX2(8), TP53(309), TWIST1(2)	16255854	455	322	305	32	58	122	63	43	166	3	<1.00e-15	2.89e-15	1.78e-13
11	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	18	DNAJA3(2), IFNG(7), IFNGR1(7), IFNGR2(4), IKBKB(9), JAK2(16), LIN7A(7), NFKB1(6), NFKBIA(4), RB1(33), RELA(3), TNF(2), TNFRSF1B(2), TP53(309), USH1C(13), WT1(16)	14547980	440	329	304	37	54	114	55	41	172	4	<1.00e-15	3.22e-15	1.80e-13
12	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	16	APAF1(10), ATM(53), BAX(3), BCL2(5), CCND1(3), CCNE1(7), CDK2(1), CDK4(3), CDKN1A(2), E2F1(3), GADD45A(2), MDM2(5), PCNA(1), RB1(33), TIMP3(4), TP53(309)	14566640	444	342	306	24	53	111	57	50	168	5	<1.00e-15	3.89e-15	1.99e-13
13	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	19	ABCB1(45), AKT1(3), ATM(53), BAX(3), CDKN1A(2), CPB2(6), CSNK1A1(2), CSNK1D(7), FHL2(2), GADD45A(2), HIC1(1), HIF1A(2), IGFBP3(4), MAPK8(2), MDM2(5), NFKBIB(3), TP53(309)	16675533	451	346	314	27	53	131	58	51	153	5	<1.00e-15	5.22e-15	2.23e-13
14	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	19	ABL1(9), ATM(53), BRCA1(22), CDKN1A(2), CHEK1(7), CHEK2(10), GADD45A(2), JUN(3), MAPK8(2), MDM2(5), MRE11A(13), NFKB1(6), NFKBIA(4), RAD50(10), RAD51(2), RBBP8(6), RELA(3), TP53(309), TP73(7)	23963460	475	347	337	35	59	126	70	56	159	5	<1.00e-15	5.33e-15	2.23e-13
15	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	22	ATM(53), ATR(26), BRCA1(22), CCNB1(2), CDC25A(4), CDC25B(1), CDC25C(8), CDC34(2), CDKN1A(2), CDKN2D(2), CHEK1(7), CHEK2(10), EP300(11), GADD45A(2), MDM2(5), MYT1(24), PRKDC(50), RPS6KA1(6), TP53(309), WEE1(4), YWHAH(1), YWHAQ(4)	33656030	555	364	419	43	61	154	83	69	183	5	<1.00e-15	5.44e-15	2.23e-13
16	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	20	AKT1(3), APAF1(10), ATM(53), BAX(3), BCL2(5), BCL2L1(3), BID(2), CASP3(5), CASP6(3), CASP7(3), CASP9(6), CYCS(2), PRKCA(10), PTK2(6), PXN(1), STAT1(7), TLN1(15), TP53(309)	22055995	446	350	309	45	54	127	57	52	151	5	3.12e-14	6.66e-15	2.56e-13
17	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	CREB1(2), FOS(3), FXYD2(1), JUN(3), KEAP1(96), MAFG(1), MAPK1(2), MAPK14(4), MAPK8(2), NFE2L2(17), PRKCA(10)	7086933	141	131	130	14	28	41	26	14	32	0	4.27e-06	2.11e-10	7.65e-09
18	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(13), EGFR(86), ERBB3(11), NRG1(18), UBE2D1(1)	8318955	129	109	78	18	11	26	16	30	46	0	0.0242	0.00552	0.189
19	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(7), CDK2(1), CDKN1B(5), CKS1B(1), CUL1(14), E2F1(3), NEDD8(3), RB1(33), SKP2(3), TFDP1(10), UBE2M(1)	6881889	81	67	80	7	5	14	15	7	40	0	0.00191	0.0710	1.000
20	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CCNE1(7), CDC34(2), CDK2(1), CUL1(14), E2F1(3), FBXW7(15), RB1(33), TFDP1(10)	6588121	85	67	84	7	6	20	13	7	39	0	0.000710	0.0785	1.000
21	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(5), EGF(13), EGFR(86), HGS(1), RAB5A(2), TF(13), TFRC(6)	10328751	126	104	77	17	6	30	21	31	38	0	0.0308	0.149	1.000
22	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(7), CCNE1(7), CDC34(2), CDK2(1), CUL1(14), E2F1(3), RB1(33), SKP2(3), TFDP1(10)	6820981	80	65	79	7	5	20	15	7	33	0	0.00138	0.154	1.000
23	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	41	APAF1(10), BAK1(3), BAX(3), BCL2(5), BCL2L1(3), BID(2), BIRC2(2), BIRC3(4), CASP2(13), CASP3(5), CASP6(3), CASP7(3), CASP8(6), CASP9(6), CYCS(2), FADD(2), FAS(4), FASLG(10), GZMB(6), JUN(3), MAP2K4(8), MAP3K1(7), MAPK10(6), MCL1(1), MDM2(5), MYC(4), NFKB1(6), NFKBIA(4), PARP1(4), PRF1(8), RELA(3), RIPK1(11), TNF(2), TNFRSF1B(2), TNFSF10(3), TP53(309), TRADD(2), TRAF1(2), TRAF2(5)	30063453	487	333	353	68	55	154	73	52	150	3	3.32e-11	0.506	1.000
24	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(8), GOT1(3), GOT2(6), TAT(9), TYR(29)	3808360	55	53	55	9	8	22	11	6	8	0	0.0326	0.604	1.000
25	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(3), GOT2(6), TAT(9)	2128311	18	18	18	2	5	7	3	2	1	0	0.0759	0.624	1.000
26	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(8), IFNG(7), IL12A(2), IL12B(3), IL2(7)	2403481	27	26	27	5	1	16	0	1	8	1	0.201	0.733	1.000
27	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(13), EGFR(86), MAP2K1(10), MAP3K1(7), MAPK14(4), NCOR2(30), RARA(7), RXRA(1), THRA(5), THRB(4)	13649211	167	133	117	28	10	40	29	37	51	0	0.0333	0.920	1.000
28	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(7)	584333	7	7	7	3	2	1	0	2	2	0	0.742	0.926	1.000
29	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(6), SLPI(1)	1382720	7	7	6	1	1	2	1	1	2	0	0.354	0.930	1.000
30	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(2), TPI1(9)	1324024	11	10	11	3	1	3	5	0	2	0	0.593	0.961	1.000
31	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	38	AKT1(3), ATF2(10), CDC42(1), DLD(9), DUSP10(11), DUSP4(2), DUSP8(2), GAB1(7), GADD45A(2), GCK(6), IL1R1(2), JUN(3), MAP2K4(8), MAP2K5(4), MAP2K7(7), MAP3K1(7), MAP3K10(4), MAP3K11(5), MAP3K12(10), MAP3K13(12), MAP3K2(6), MAP3K3(10), MAP3K4(21), MAP3K5(14), MAP3K7(10), MAP3K9(17), MAPK10(6), MAPK7(7), MAPK8(2), MAPK9(8), MYEF2(12), NFATC3(15), NR2C2(2), PAPPA(32), SHC1(6), TP53(309), TRAF6(6), ZAK(7)	40358111	605	356	469	78	86	195	84	60	177	3	1.23e-14	0.973	1.000
32	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(7), PAPSS1(5), PAPSS2(10), SULT1A2(5), SULT1E1(11), SULT2A1(6), SUOX(5)	4954097	49	45	49	7	3	21	9	7	9	0	0.0373	0.977	1.000
33	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(8), GLS2(6), GLUD1(4), GLUD2(15)	3672284	33	31	33	5	0	17	9	2	5	0	0.130	0.984	1.000
34	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD28(4), CD4(8), CD80(3), HLA-DRA(3), HLA-DRB1(5), IL10(2), IL2(7), IL4(1)	3223968	33	29	29	7	1	14	1	3	14	0	0.418	0.988	1.000
35	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(1), LIPT1(2)	1235104	3	3	3	0	0	1	0	1	1	0	0.495	0.990	1.000
36	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3D(2), CD3E(2)	923089	4	4	4	2	0	0	1	1	2	0	0.858	0.992	1.000
37	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	ASAH1(3), BFAR(5), BRAF(44), CAMP(4), CREB1(2), CREB5(18), MAPK1(2), RAF1(6), SNX13(9), SRC(2)	8973163	95	80	70	12	8	42	29	2	13	1	0.00220	0.993	1.000
38	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(4), FDPS(5), IDI1(2), SQLE(4)	2563848	15	15	15	3	2	5	4	1	3	0	0.434	0.993	1.000
39	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(8), ALDH1A2(8), RDH5(1)	3156193	17	17	17	2	1	7	3	4	2	0	0.122	0.993	1.000
40	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(3), SUCLA2(5)	1692843	8	7	8	2	0	4	0	2	2	0	0.527	0.995	1.000
41	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD28(4), CD4(8), HLA-DRA(3), HLA-DRB1(5)	1927106	20	20	16	6	1	9	1	2	7	0	0.708	0.996	1.000
42	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	28	BRAF(44), CPEB1(12), EGFR(86), ERBB2(12), ERBB4(51), ETS1(8), ETS2(6), ETV6(5), ETV7(2), FMN2(65), GRB2(6), KRAS(169), MAP2K1(10), MAPK1(2), MAPK3(3), NOTCH1(26), NOTCH2(26), NOTCH3(11), NOTCH4(53), PIWIL1(17), PIWIL2(10), PIWIL3(9), PIWIL4(7), RAF1(6), SOS1(17), SOS2(13), SPIRE1(5), SPIRE2(5)	41513875	686	397	444	100	52	330	125	64	112	3	3.18e-13	0.996	1.000
43	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(4), FDPS(5), GGPS1(2), IDI1(2), IDI2(1), SQLE(4)	3440819	18	18	18	3	2	7	5	1	3	0	0.308	0.997	1.000
44	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	64	APAF1(10), ATM(53), ATR(26), BAI1(24), BAX(3), BID(2), CASP3(5), CASP8(6), CASP9(6), CCNB1(2), CCNB3(35), CCND1(3), CCND2(4), CCND3(1), CCNE1(7), CCNE2(3), CCNG1(2), CCNG2(1), CD82(5), CDK2(1), CDK4(3), CDK6(5), CDKN1A(2), CDKN2A(22), CHEK1(7), CHEK2(10), CYCS(2), DDB2(2), EI24(1), FAS(4), GADD45A(2), GADD45B(1), GADD45G(1), GTSE1(6), IGF1(4), IGFBP3(4), MDM2(5), MDM4(4), PERP(1), PPM1D(8), PTEN(11), RCHY1(2), RFWD2(16), RRM2(6), RRM2B(3), SERPINB5(8), SERPINE1(14), SESN1(1), SESN2(5), SESN3(2), SFN(1), SIAH1(1), STEAP3(1), THBS1(8), TNFRSF10B(3), TP53(309), TP53I3(2), TP73(7), TSC2(13), ZMAT3(5)	52014903	711	379	569	91	81	220	117	80	206	7	<1.00e-15	0.997	1.000
45	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(8), HLCS(3), SPCS1(1), SPCS3(2)	2479058	14	14	14	3	1	6	5	1	1	0	0.385	0.997	1.000
46	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(6), PGLYRP2(9)	1454837	15	15	14	5	0	4	4	3	4	0	0.632	0.998	1.000
47	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(53), CDC25A(4), CDC25B(1), CDC25C(8), CHEK1(7), MYT1(24), WEE1(4), YWHAH(1)	11082061	102	86	100	12	10	26	15	16	33	2	0.00197	0.998	1.000
48	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(6), ARG1(2), GLS(8), GLUD1(4), OAT(3), PRODH(4)	4404565	27	26	27	4	3	11	6	2	5	0	0.131	0.999	1.000
49	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(3), MTMR1(11), MTMR2(2), MTMR6(9), NFS1(5), PHPT1(1), THTPA(1), TPK1(11)	5148488	43	39	41	7	2	17	12	6	6	0	0.111	0.999	1.000
50	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(13), CYP2C9(8)	1642731	21	21	21	7	3	9	4	2	3	0	0.625	0.999	1.000
51	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(2), GSTZ1(2), HGD(5)	1795382	9	8	9	4	0	2	0	2	5	0	0.846	0.999	1.000
52	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(7), CCNA2(6), CCND1(3), CCNE1(7), CCNE2(3), CDK2(1), CDK4(3), CDKN1B(5), CDKN2A(22), E2F1(3), E2F2(5), E2F4(5), PRB1(5)	7145755	75	64	70	11	10	28	14	5	18	0	0.0127	1.000	1.000
53	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALT(5), TGDS(1), UGDH(6), UGP2(4), UXS1(6)	3969223	22	21	22	4	2	8	4	3	5	0	0.365	1.000	1.000
54	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(1), ECHS1(4), EHHADH(13), HADHA(3), SDS(4)	3872652	25	23	24	5	4	8	5	4	4	0	0.265	1.000	1.000
55	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(2), ALDOA(4), ALDOB(8), ALDOC(2), TPI1(9)	3157676	25	21	25	5	3	9	7	0	6	0	0.285	1.000	1.000
56	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALT(5), TGDS(1), UGDH(6), UXS1(6)	3115757	18	17	18	4	2	8	3	2	3	0	0.432	1.000	1.000
57	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CCR5(4), CD28(4), CD3D(2), CD3E(2), CD4(8)	2606736	20	20	20	6	1	9	1	4	5	0	0.494	1.000	1.000
58	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCL11(2), CCR3(4), HLA-DRA(3), HLA-DRB1(5), IL3(4), IL5(2)	2466150	20	20	16	6	0	5	5	4	6	0	0.842	1.000	1.000
59	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCL11(2), CCR3(4), CD4(8), HLA-DRA(3), HLA-DRB1(5), IL1B(1), IL4(1), IL5(2), IL5RA(9), IL6(2)	4330878	37	36	33	9	1	11	7	5	13	0	0.548	1.000	1.000
60	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(4), ACP2(4), ACP5(4), ACPP(8), ACPT(7), ENPP1(14), ENPP3(19), FLAD1(5), TYR(29)	7810350	94	85	93	17	10	37	19	11	17	0	0.0332	1.000	1.000
61	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(4), CDC25B(1), CDK7(3), CDKN1A(2), CHEK1(7), NEK1(11), WEE1(4)	5532285	32	30	32	5	1	11	8	5	7	0	0.214	1.000	1.000
62	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	ATP6V0C(4), GGT1(1), SHMT1(2), SHMT2(2)	3314036	9	9	8	0	2	3	2	1	1	0	0.0776	1.000	1.000
63	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ2(1), COQ3(5), COQ5(3), COQ6(1), COQ7(5), NDUFA12(5), NDUFA13(1), NDUFB11(6)	3215199	27	24	27	8	7	6	3	3	8	0	0.553	1.000	1.000
64	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(2), ACAT2(2), HMGCL(1), OXCT1(7)	2736802	12	12	12	9	1	2	3	2	4	0	0.994	1.000	1.000
65	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	59	ALG2(3), BAK1(3), BAX(3), BFAR(5), BTK(25), CAD(25), CASP10(7), CASP3(5), CASP8(6), CSNK1A1(2), DAXX(8), DEDD(2), DEDD2(3), DFFA(3), DIABLO(1), EGFR(86), EPHB2(10), FADD(2), FAF1(10), FAIM2(6), HSPB1(1), IL1A(4), MAP2K4(8), MAP2K7(7), MAP3K1(7), MAP3K5(14), MAPK1(2), MAPK10(6), MAPK8(2), MAPK8IP1(4), MAPK8IP2(2), MAPK8IP3(7), MAPK9(8), MET(22), NFAT5(13), NFKB1(6), NFKB2(5), NFKBIA(4), NFKBIB(3), NFKBIE(2), NFKBIL1(1), NR0B2(3), PFN1(1), PFN2(1), PTPN13(21), RALBP1(3), RIPK1(11), ROCK1(19), SMPD1(3), TNFRSF6B(1), TP53(309), TPX2(12), TRAF2(5)	58000166	732	390	547	101	77	217	113	98	223	4	6.77e-15	1.000	1.000
66	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(17), PARK2(15), SNCA(5), SNCAIP(12), UBE2E2(4), UBE2G2(1), UBE2L3(1), UBE2L6(1)	5191088	56	53	56	13	7	26	12	2	9	0	0.175	1.000	1.000
67	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYA(1), NFYB(1), NFYC(6), RB1(33), SP1(6), SP3(6)	5366971	53	50	52	12	0	6	10	2	35	0	0.669	1.000	1.000
68	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(4), ACADM(8), ACADS(1), ACAT1(2), ECHS1(4), HADHA(3)	4325350	22	21	22	7	0	4	5	4	9	0	0.808	1.000	1.000
69	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(8), PLCD1(4), PRKCA(10), TGM2(6)	3986370	28	25	28	8	5	12	3	5	3	0	0.341	1.000	1.000
70	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	66	APAF1(10), BAK1(3), BAX(3), BCL2(5), BCL2L1(3), BCL2L11(4), BID(2), BIRC2(2), BIRC3(4), BIRC5(3), BNIP3L(1), CASP1(8), CASP10(7), CASP2(13), CASP3(5), CASP4(6), CASP6(3), CASP7(3), CASP8(6), CASP9(6), CHUK(7), CYCS(2), DFFA(3), DFFB(4), FADD(2), FAS(4), FASLG(10), GZMB(6), HELLS(4), IKBKB(9), IRF1(1), IRF2(3), IRF4(12), IRF5(1), IRF6(12), IRF7(3), JUN(3), LTA(3), MAP2K4(8), MAP3K1(7), MAPK10(6), MDM2(5), MYC(4), NFKB1(6), NFKBIA(4), NFKBIB(3), NFKBIE(2), PLEKHG5(10), PRF1(8), RELA(3), RIPK1(11), TNF(2), TNFRSF10B(3), TNFRSF1B(2), TNFRSF21(3), TNFRSF25(2), TNFSF10(3), TP53(309), TP73(7), TRADD(2), TRAF1(2), TRAF2(5), TRAF3(4)	45868695	607	350	474	90	69	195	94	64	182	3	3.27e-12	1.000	1.000
71	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	CDK5(3), CDK5R1(3), EGR1(6), HRAS(2), KLK2(10), MAP2K1(10), MAP2K2(1), MAPK1(2), MAPK3(3), NGFR(5), RAF1(6)	6499475	51	47	47	10	6	22	14	4	5	0	0.0444	1.000	1.000
72	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNA1(2), IFNB1(7), IFNG(7), IL10(2), IL12A(2), IL12B(3), IL13(2), IL15(6), IL16(28), IL1A(4), IL2(7), IL3(4), IL4(1), IL5(2), IL6(2), IL9(1), LTA(3), TNF(2)	8021597	85	70	85	19	5	47	10	10	12	1	0.0488	1.000	1.000
73	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA2(2), ACAT1(2), ACAT2(2), ECHS1(4), EHHADH(13), HADHA(3), HADHB(10), SDS(4)	6711531	40	37	39	9	4	11	13	6	6	0	0.325	1.000	1.000
74	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH9A1(3)	6404267	49	44	49	11	5	19	11	7	7	0	0.165	1.000	1.000
75	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH9A1(3)	6404267	49	44	49	11	5	19	11	7	7	0	0.165	1.000	1.000
76	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(12), ESR2(6), ITPKA(2), PDE1A(17), PDE1B(13), PLCB1(52), PLCB2(12), PRL(3), TRH(4), VIP(6)	8866426	127	99	125	28	19	53	24	10	21	0	0.0217	1.000	1.000
77	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCNA1(7), CCNB1(2), CCND1(3), CCND2(4), CCND3(1), CCNE1(7), CCNH(3), CDC25A(4), CDK2(1), CDK4(3), CDK6(5), CDK7(3), CDKN1A(2), CDKN1B(5), CDKN2A(22), CDKN2D(2), E2F1(3), RB1(33), RBL1(7), TFDP1(10)	12813726	127	103	121	24	9	35	21	12	50	0	0.0758	1.000	1.000
78	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(7), ENO2(2), ENO3(3), FARS2(5), GOT1(3), GOT2(6), PAH(11), TAT(9), YARS(3)	6722782	49	46	49	10	7	19	11	4	8	0	0.113	1.000	1.000
79	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	BCL2(5), CASP3(5), CASP8(6), CFLAR(2)	3134220	18	17	18	8	1	6	7	1	3	0	0.873	1.000	1.000
80	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(8), ERBB4(51), NRG2(3), NRG3(31), PRKCA(10), PSEN1(6)	7252332	109	91	108	28	13	47	22	12	15	0	0.190	1.000	1.000
81	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(4), SEC61A2(6), SRP54(5), SRP68(4), SRP72(9), SRPR(5)	6095457	33	29	32	7	2	8	12	2	9	0	0.557	1.000	1.000
82	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RANBP1(1), RANBP2(34), RANGAP1(4)	6781581	39	36	39	8	6	16	9	4	4	0	0.268	1.000	1.000
83	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	14	EPO(6), FLT3(24), IGF1(4), IL1A(4), IL3(4), IL6(2), IL9(1), KITLG(6), TGFB1(3), TGFB2(10)	6569556	64	57	64	15	6	25	13	6	14	0	0.144	1.000	1.000
84	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(8), ADH1B(12), ADH4(4), ADH6(8), ADH7(11), ADHFE1(5)	4573767	48	43	45	14	3	25	7	2	11	0	0.465	1.000	1.000
85	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(4), ACP2(4), ACP5(4), ACP6(3), ACPP(8), ACPT(7), ENPP1(14), ENPP3(19), FLAD1(5), LHPP(3), MTMR1(11), MTMR2(2), MTMR6(9), PHPT1(1), TYR(29)	12088037	123	101	121	22	12	52	24	15	20	0	0.0154	1.000	1.000
86	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD28(4), CD3D(2), CD3E(2), CD80(3), CD86(11), CTLA4(3), GRB2(6), HLA-DRA(3), HLA-DRB1(5), ICOS(5), IL2(7), ITK(16), LCK(9), PIK3CA(30), PIK3R1(4), PTPN11(9)	10376357	119	98	104	26	6	51	21	13	28	0	0.179	1.000	1.000
87	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH9A1(3), ECHS1(4), EHHADH(13), HADHA(3), SDS(4)	9729696	73	64	72	15	8	27	16	11	11	0	0.0769	1.000	1.000
88	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(10), BMPR1A(4), BMPR1B(7), BMPR2(10)	5050548	31	28	30	7	5	8	10	4	4	0	0.329	1.000	1.000
89	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(1), IFNG(7), IFNGR1(7), JAK1(11), JAK2(16), PLA2G2A(5), PTPRU(19), REG1A(20), STAT1(7)	9229358	93	77	91	19	11	37	15	9	20	1	0.0404	1.000	1.000
90	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(7), IFNGR1(7), IFNGR2(4), JAK1(11), JAK2(16), STAT1(7)	6617914	52	50	52	12	6	15	12	7	11	1	0.404	1.000	1.000
91	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(3), CYP2E1(7), NR1I3(9), PTGS1(18), PTGS2(12)	4326176	49	43	48	13	3	24	10	3	9	0	0.170	1.000	1.000
92	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(5), FARSA(5), FARSB(5), GOT1(3), GOT2(6), PAH(11), TAT(9), YARS(3), YARS2(10)	7030650	57	53	57	12	12	19	12	3	11	0	0.0918	1.000	1.000
93	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(2), CLOCK(4), CRY1(7), CRY2(6), CSNK1E(6), PER1(10)	6788509	35	31	33	7	5	12	8	2	8	0	0.247	1.000	1.000
94	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	FUT1(4), FUT2(1), FUT3(5), FUT5(3), FUT6(4), ST3GAL3(4)	3992736	21	19	21	6	5	6	5	2	3	0	0.439	1.000	1.000
95	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(9), CSAD(6), GAD1(7), GAD2(27), GGT1(1)	4611376	50	45	50	14	4	22	10	4	10	0	0.387	1.000	1.000
96	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(2), CCNH(3), CDC25A(4), CDC25B(1), CDC25C(8), CDK7(3), MNAT1(2), SHH(2), XPO1(12)	6942669	37	32	37	8	3	14	8	6	6	0	0.313	1.000	1.000
97	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	64	ATM(53), CCNA1(7), CCNB1(2), CCND1(3), CCND2(4), CCND3(1), CCNE1(7), CCNE2(3), CCNG2(1), CCNH(3), CDC25A(4), CDK2(1), CDK4(3), CDK7(3), CDKN1A(2), CDKN1B(5), CDKN2A(22), CDKN2D(2), CREB3L1(4), CREB3L3(3), CREB3L4(2), E2F1(3), E2F2(5), E2F3(2), E2F4(5), E2F5(1), E2F6(1), GADD45A(2), GBA2(5), MCM2(5), MCM3(12), MCM4(11), MCM5(10), MCM6(16), MCM7(5), MDM2(5), MNAT1(2), MYC(4), MYT1(24), NACA(15), PCNA(1), POLA2(7), POLE(31), POLE2(1), PRIM1(3), RB1(33), RBL1(7), RPA1(2), RPA2(2), RPA3(1), TFDP1(10), TFDP2(7), TNXB(32), TP53(309), WEE1(4)	61819242	718	384	575	100	94	210	103	74	231	6	3.44e-15	1.000	1.000
98	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(9), LPL(8), NR3C1(8), PPARG(8), RXRA(1), TNF(2)	4649244	36	35	36	10	3	14	8	3	7	1	0.359	1.000	1.000
99	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	ANP32A(3), APEX1(3), CREBBP(30), DFFA(3), DFFB(4), GZMA(8), GZMB(6), PRF1(8), SET(1)	8510668	66	56	66	11	9	26	14	5	12	0	0.0283	1.000	1.000
100	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(2), IL13RA1(3), IL13RA2(13), IL4R(10), JAK1(11), JAK2(16), TYK2(5)	8379151	60	54	60	13	8	20	15	8	9	0	0.166	1.000	1.000
101	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(2), IL13RA1(3), IL13RA2(13), IL4R(10), JAK1(11), JAK2(16), TYK2(5)	8379151	60	54	60	13	8	20	15	8	9	0	0.166	1.000	1.000
102	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(6), F13B(28), HSD17B1(2), HSD17B2(6), HSD17B3(3), HSD17B4(8), HSD17B7(3), HSD3B1(6), HSD3B2(15)	6540842	77	66	76	20	7	33	16	8	12	1	0.214	1.000	1.000
103	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	AKT1(3), PIK3CA(30), PIK3R1(4), PLCB1(52), PLCG1(7), PRKCA(10), VAV1(8)	10362726	114	90	102	24	10	57	21	9	17	0	0.0444	1.000	1.000
104	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA1(2), NDUFA10(5), NDUFA11(1), NDUFA4(2), NDUFA5(2), NDUFA8(5), NDUFB2(2), NDUFB4(1), NDUFB5(6), NDUFB6(2), NDUFS1(10), NDUFS2(4), NDUFV1(2), NDUFV2(1)	5579121	45	38	45	10	5	19	7	3	10	1	0.233	1.000	1.000
105	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH7A1(3), ALDH9A1(3), MIOX(2), UGDH(6)	6783953	44	39	44	11	4	18	12	4	6	0	0.283	1.000	1.000
106	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(6), CD34(13), CD3D(2), CD3E(2), CD4(8), CD58(1), CD8A(4), IL3(4), IL6(2), KITLG(6)	4993395	48	39	47	15	4	21	6	4	13	0	0.469	1.000	1.000
107	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	28	CD4(8), CSF1(1), HLA-DRA(3), HLA-DRB1(5), IFNA1(2), IFNB1(7), IFNG(7), IL10(2), IL12A(2), IL12B(3), IL13(2), IL15(6), IL1A(4), IL2(7), IL3(4), IL4(1), IL5(2), IL6(2), IL7(2), LTA(3), PDGFA(5), TGFB1(3), TGFB2(10), TNF(2)	10608184	93	81	89	22	4	41	12	13	22	1	0.144	1.000	1.000
108	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(22), PDXK(2), PDXP(1), PNPO(2), PSAT1(5)	3885247	32	28	32	10	2	13	9	5	3	0	0.594	1.000	1.000
109	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	BPNT1(7), CHST11(2), CHST12(6), CHST13(3), PAPSS1(5), PAPSS2(10), SULT1A1(5), SULT1A2(5), SULT1E1(11), SULT2A1(6), SULT2B1(2), SUOX(5)	7381636	67	55	66	16	8	24	13	9	13	0	0.133	1.000	1.000
110	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(9), RAB27A(1), RAB4A(2), RAB5A(2), RAB6A(1)	3425847	15	14	15	9	1	5	5	3	1	0	0.974	1.000	1.000
111	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(3), AASDHPPT(4), AASS(20), KARS(8)	3810563	35	30	35	10	4	18	5	5	3	0	0.530	1.000	1.000
112	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	13	AKT1(3), CAT(3), GH1(7), GHR(19), HRAS(2), IGF1(4), IGF1R(8), PIK3CA(30), PIK3R1(4), SHC1(6), SOD1(1), SOD2(6), SOD3(1)	10723295	94	84	82	21	5	49	19	7	14	0	0.0905	1.000	1.000
113	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(10), CSF1R(18), EGF(13), EGFR(86), GRB2(6), MET(22), PDGFRA(41), PRKCA(10), SH3GLB2(1), SH3KBP1(7), SRC(2)	15682674	216	167	164	45	18	57	34	42	64	1	0.0879	1.000	1.000
114	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	ADAM17(8), DLL1(5), FURIN(7), NOTCH1(26), PSEN1(6)	6936866	52	47	52	13	13	14	7	7	11	0	0.156	1.000	1.000
115	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	AKT1(3), CCND1(3), CCNE1(7), CDK2(1), CDK4(3), CDK6(5), CDKN1A(2), CDKN1B(5), E2F1(3), HRAS(2), MAPK1(2), MAPK3(3), NFKB1(6), NFKBIA(4), PAK1(9), PIK3CA(30), PIK3R1(4), RAF1(6), RB1(33), RELA(3), TFDP1(10)	16217036	144	118	127	29	10	47	26	9	52	0	0.0664	1.000	1.000
116	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(4), CD3D(2), CD3E(2), IFNG(7), IL2(7), IL2RA(6), IL4(1), TGFB1(3), TGFB2(10), TGFBR1(7), TGFBR2(7), TGFBR3(19), TOB1(4), TOB2(4)	8525310	83	75	83	21	5	36	14	5	22	1	0.238	1.000	1.000
117	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(3), CAMP(4), DAG1(3), GNAQ(5), ITPKA(2), ITPKB(7)	4773910	24	23	24	8	3	8	7	3	3	0	0.607	1.000	1.000
118	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(9), ALPL(3), ALPP(13), ALPPL2(4), DHFR(2), FPGS(3), GCH1(3), GGH(9), SPR(3)	5125898	49	42	49	15	2	16	14	5	12	0	0.462	1.000	1.000
119	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(2), ACAT2(2), ACYP2(1), ECHS1(4), EHHADH(13), GCDH(7), HADHA(3), SDHB(1), SDS(4)	6259671	37	33	35	10	6	10	9	5	7	0	0.448	1.000	1.000
120	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	ASRGL1(3), GBA(7), GGT1(1), SHMT1(2), SHMT2(2)	4406742	15	15	15	6	2	5	4	1	3	0	0.822	1.000	1.000
121	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5(3), CDK5R1(3), CSNK1D(7), DRD1(13), DRD2(26), GRM1(48), PLCB1(52), PPP1CA(2), PPP1R1B(1), PPP2CA(1), PPP3CA(14), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2)	12833490	194	139	190	39	26	84	36	16	30	2	0.00175	1.000	1.000
122	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CCR5(4), CD2(6), CD3D(2), CD3E(2), CD4(8), CXCR3(3), IFNG(7), IL12A(2), IL12B(3), IL12RB1(5), IL12RB2(15), JAK2(16), STAT4(11), TYK2(5)	11741422	89	72	89	19	7	36	15	10	20	1	0.0702	1.000	1.000
123	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(2), ECHS1(4), HADH(2), HADHA(3), HADHB(10), HSD17B10(2), HSD17B4(8), MECR(2), PPT1(2), PPT2(6)	6827328	41	40	40	11	3	11	14	5	8	0	0.517	1.000	1.000
124	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(2), ASL(4), CPS1(71), GLS(8), GLUD1(4), GOT1(3)	6263846	92	82	91	25	5	40	17	13	17	0	0.451	1.000	1.000
125	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(18), AGT(4), AGTR2(6), EDN1(1), EDNRA(3), EDNRB(16), EGF(13), EGFR(86), FOS(3), HRAS(2), JUN(3), MYC(4), NFKB1(6), PLCG1(7), PRKCA(10), RELA(3)	16592775	185	143	136	36	17	47	30	40	51	0	0.0584	1.000	1.000
126	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	14	CD4(8), CD8A(4), CSF1(1), EPO(6), IL2(7), IL3(4), IL4(1), IL5(2), IL6(2), IL7(2), IL9(1)	4807995	38	33	38	13	1	18	7	4	8	0	0.623	1.000	1.000
127	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(5), NFKB1(6), NFKBIA(4), PLCB1(52), PRKCA(10), RELA(3)	6638404	80	70	79	22	7	38	12	8	15	0	0.334	1.000	1.000
128	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(8), ALOX15(5), ALOX15B(6), ALOX5(10), ALOX5AP(2), DPEP1(5), GGT1(1), LTA4H(3), PLA2G2A(5), PLA2G6(3), PTGDS(4), PTGIS(12), PTGS1(18), PTGS2(12), TBXAS1(11)	11922131	105	86	102	23	18	37	22	13	15	0	0.0217	1.000	1.000
129	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	AKT1(3), CREB1(2), MAP2K1(10), MAP2K2(1), MAP2K3(13), MAP2K6(5), MAP3K1(7), MAPK1(2), MAPK14(4), MAPK3(3), NFKB1(6), PIK3CA(30), PIK3R1(4), RB1(33), RELA(3), SP1(6)	15605414	132	111	119	27	3	44	26	10	49	0	0.155	1.000	1.000
130	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(7), FOS(3), HRAS(2), JUN(3), MAP2K1(10), MAPK1(2), MAPK3(3), MYC(4), NFKB1(6), NFKBIA(4), PLCB1(52), PRKCA(10), RAF1(6), RELA(3), TNF(2)	12532437	117	99	112	28	14	49	20	13	21	0	0.0664	1.000	1.000
131	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM1(3), CALM2(1), CAMK1(1), CAMK1G(2), CAMK2A(3), CAMK2B(16), CAMK2D(7), CAMK4(16), CAMKK1(4), CAMKK2(3), CREB1(2), SYT1(6)	9210287	64	59	64	16	5	26	11	7	15	0	0.227	1.000	1.000
132	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	247	ACVR1B(11), ACVR1C(11), AKT1(3), AKT2(7), AKT3(7), ARRB1(2), ARRB2(4), ATF2(10), ATF4(2), BDNF(1), BRAF(44), CACNA1A(32), CACNA1B(39), CACNA1C(61), CACNA1D(21), CACNA1E(111), CACNA1F(30), CACNA1G(27), CACNA1H(21), CACNA1I(31), CACNA1S(23), CACNA2D1(46), CACNA2D3(24), CACNA2D4(25), CACNB1(5), CACNB2(23), CACNB3(1), CACNB4(4), CACNG1(2), CACNG2(6), CACNG3(18), CACNG4(5), CACNG5(8), CACNG6(11), CACNG7(9), CACNG8(5), CASP3(5), CD14(1), CDC25B(1), CDC42(1), CHUK(7), CRK(1), CRKL(4), DAXX(8), DDIT3(2), DUSP1(1), DUSP10(11), DUSP14(2), DUSP16(3), DUSP2(2), DUSP3(4), DUSP4(2), DUSP5(3), DUSP6(4), DUSP7(3), DUSP8(2), DUSP9(6), EGF(13), EGFR(86), ELK1(3), ELK4(6), FAS(4), FASLG(10), FGF1(2), FGF10(10), FGF12(7), FGF13(10), FGF14(11), FGF16(1), FGF17(1), FGF18(6), FGF19(2), FGF20(1), FGF21(3), FGF22(2), FGF23(12), FGF3(2), FGF4(2), FGF5(4), FGF6(9), FGF7(3), FGF8(2), FGF9(3), FGFR1(4), FGFR2(12), FGFR3(2), FGFR4(10), FLNA(31), FLNB(16), FLNC(55), FOS(3), GADD45A(2), GADD45B(1), GADD45G(1), GNA12(1), GNG12(3), GRB2(6), HRAS(2), IKBKB(9), IL1A(4), IL1B(1), IL1R1(2), IL1R2(5), JUN(3), JUND(1), KRAS(169), MAP2K1(10), MAP2K2(1), MAP2K3(13), MAP2K4(8), MAP2K5(4), MAP2K6(5), MAP2K7(7), MAP3K1(7), MAP3K10(4), MAP3K12(10), MAP3K13(12), MAP3K2(6), MAP3K3(10), MAP3K4(21), MAP3K5(14), MAP3K6(4), MAP3K7(10), MAP3K8(4), MAP4K1(12), MAP4K2(4), MAP4K3(12), MAP4K4(8), MAPK1(2), MAPK10(6), MAPK12(2), MAPK13(1), MAPK14(4), MAPK3(3), MAPK7(7), MAPK8(2), MAPK8IP1(4), MAPK8IP2(2), MAPK8IP3(7), MAPK9(8), MAPKAPK2(2), MAPKAPK3(3), MAPKAPK5(5), MAPT(15), MAX(8), MEF2C(6), MKNK1(4), MKNK2(2), MOS(9), MRAS(1), MYC(4), NF1(65), NFATC2(15), NFATC4(11), NFKB1(6), NFKB2(5), NLK(3), NR4A1(5), NRAS(4), NTF3(11), NTRK1(14), NTRK2(21), PAK1(9), PAK2(3), PDGFA(5), PDGFB(2), PDGFRA(41), PDGFRB(18), PLA2G12A(4), PLA2G12B(3), PLA2G1B(2), PLA2G2A(5), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(6), PLA2G4A(21), PLA2G6(3), PPM1A(6), PPM1B(9), PPP3CA(14), PPP3CB(3), PPP3CC(3), PPP3R1(5), PPP5C(2), PRKACA(3), PRKACB(9), PRKACG(4), PRKCA(10), PRKCG(20), PRKX(3), PTPN5(12), PTPN7(1), PTPRR(16), RAC2(2), RAF1(6), RAP1A(1), RAP1B(2), RAPGEF2(24), RASA1(11), RASA2(8), RASGRF1(11), RASGRF2(22), RASGRP1(3), RASGRP2(7), RASGRP3(11), RASGRP4(9), RPS6KA1(6), RPS6KA2(8), RPS6KA3(6), RPS6KA4(4), RPS6KA5(10), RPS6KA6(18), RRAS(1), RRAS2(3), SOS1(17), SOS2(13), SRF(1), STK3(4), STK4(6), STMN1(2), TAOK1(8), TAOK2(11), TAOK3(9), TGFB1(3), TGFB2(10), TGFBR1(7), TGFBR2(7), TNF(2), TP53(309), TRAF2(5), TRAF6(6), ZAK(7)	227344397	2622	515	2235	655	330	1010	488	262	519	13	1.19e-10	1.000	1.000
133	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	192	ACTB(10), ACTG1(6), ACTN1(7), ACTN2(43), ACTN4(6), AKT1(3), AKT2(7), AKT3(7), ARHGAP5(17), BCAR1(3), BCL2(5), BIRC2(2), BIRC3(4), BRAF(44), CAPN2(5), CAV1(1), CAV2(1), CAV3(3), CCND1(3), CCND2(4), CCND3(1), CDC42(1), CHAD(1), COL11A1(138), COL11A2(21), COL1A1(21), COL1A2(41), COL2A1(24), COL3A1(67), COL4A1(36), COL4A2(40), COL4A4(22), COL4A6(28), COL5A1(42), COL5A2(57), COL5A3(29), COL6A1(11), COL6A2(21), COL6A3(80), COL6A6(45), COMP(4), CRK(1), CRKL(4), CTNNB1(20), DIAPH1(3), DOCK1(15), EGF(13), EGFR(86), ELK1(3), ERBB2(12), FARP2(7), FIGF(4), FLNA(31), FLNB(16), FLNC(55), FLT1(31), FN1(25), FYN(8), GRB2(6), GSK3B(4), HGF(54), HRAS(2), IBSP(9), IGF1(4), IGF1R(8), ILK(1), ITGA1(14), ITGA10(16), ITGA11(12), ITGA2(25), ITGA2B(12), ITGA3(8), ITGA4(38), ITGA5(11), ITGA6(12), ITGA7(13), ITGA8(59), ITGA9(6), ITGAV(14), ITGB1(6), ITGB3(13), ITGB4(10), ITGB5(4), ITGB6(11), ITGB7(2), ITGB8(15), JUN(3), KDR(56), LAMA1(63), LAMA2(81), LAMA3(36), LAMA4(40), LAMA5(33), LAMB1(40), LAMB2(21), LAMB3(19), LAMB4(52), LAMC1(27), LAMC2(11), LAMC3(25), MAP2K1(10), MAPK1(2), MAPK10(6), MAPK3(3), MAPK8(2), MAPK9(8), MET(22), MYL2(8), MYL5(2), MYL7(4), MYL9(3), MYLK(26), MYLK2(9), PAK1(9), PAK2(3), PAK3(16), PAK4(6), PAK6(2), PAK7(37), PARVA(3), PARVB(3), PARVG(8), PDGFA(5), PDGFB(2), PDGFC(3), PDGFD(9), PDGFRA(41), PDGFRB(18), PDPK1(3), PGF(1), PIK3CA(30), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PIP5K1C(4), PPP1CA(2), PPP1CB(4), PPP1CC(1), PPP1R12A(8), PRKCA(10), PRKCG(20), PTEN(11), PTK2(6), PXN(1), RAC2(2), RAF1(6), RAP1A(1), RAP1B(2), RAPGEF1(7), RELN(104), RHOA(4), ROCK1(19), ROCK2(9), SHC1(6), SHC2(5), SHC3(8), SHC4(7), SOS1(17), SOS2(13), SPP1(5), SRC(2), THBS1(8), THBS2(35), THBS3(5), THBS4(8), TLN1(15), TLN2(30), TNC(26), TNN(87), TNR(112), TNXB(32), VASP(2), VAV1(8), VAV2(8), VAV3(32), VCL(8), VEGFA(1), VEGFB(2), VEGFC(21), VTN(4), VWF(32), ZYX(6)	296509541	3289	504	3158	924	378	1412	606	274	602	17	0.000397	1.000	1.000
134	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	203	ABI2(4), ACTN1(7), ACTN2(43), ACTN4(6), APC(33), APC2(8), ARAF(5), ARHGEF1(5), ARHGEF12(24), ARHGEF4(11), ARHGEF6(21), ARHGEF7(6), ARPC1A(3), ARPC1B(4), ARPC2(3), ARPC3(2), ARPC5(1), BAIAP2(3), BCAR1(3), BDKRB1(1), BDKRB2(3), BRAF(44), CD14(1), CDC42(1), CFL2(3), CHRM1(5), CHRM2(39), CHRM3(27), CHRM4(8), CHRM5(6), CRK(1), CRKL(4), CSK(2), CYFIP1(12), CYFIP2(11), DIAPH1(3), DIAPH2(18), DIAPH3(16), DOCK1(15), EGF(13), EGFR(86), EZR(3), F2(9), F2R(10), FGD1(13), FGD3(8), FGF1(2), FGF10(10), FGF12(7), FGF13(10), FGF14(11), FGF16(1), FGF17(1), FGF18(6), FGF19(2), FGF20(1), FGF21(3), FGF22(2), FGF23(12), FGF3(2), FGF4(2), FGF5(4), FGF6(9), FGF7(3), FGF8(2), FGF9(3), FGFR1(4), FGFR2(12), FGFR3(2), FGFR4(10), FN1(25), GIT1(3), GNA12(1), GNA13(6), GNG12(3), GSN(4), HRAS(2), IQGAP1(8), IQGAP2(31), IQGAP3(16), ITGA1(14), ITGA10(16), ITGA11(12), ITGA2(25), ITGA2B(12), ITGA3(8), ITGA4(38), ITGA5(11), ITGA6(12), ITGA7(13), ITGA8(59), ITGA9(6), ITGAD(38), ITGAE(20), ITGAL(26), ITGAM(24), ITGAV(14), ITGAX(52), ITGB1(6), ITGB2(8), ITGB3(13), ITGB4(10), ITGB5(4), ITGB6(11), ITGB7(2), ITGB8(15), KRAS(169), LIMK1(3), LIMK2(3), MAP2K1(10), MAP2K2(1), MAPK1(2), MAPK3(3), MOS(9), MRAS(1), MSN(8), MYH10(14), MYH14(9), MYH9(19), MYL2(8), MYL5(2), MYL7(4), MYL9(3), MYLK(26), MYLK2(9), NCKAP1(11), NCKAP1L(24), NRAS(4), PAK1(9), PAK2(3), PAK3(16), PAK4(6), PAK6(2), PAK7(37), PDGFA(5), PDGFB(2), PDGFRA(41), PDGFRB(18), PFN1(1), PFN2(1), PFN4(2), PIK3CA(30), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PIP4K2A(7), PIP4K2B(3), PIP4K2C(7), PIP5K1A(6), PIP5K1B(6), PIP5K1C(4), PPP1CA(2), PPP1CB(4), PPP1CC(1), PPP1R12A(8), PPP1R12B(15), PTK2(6), PXN(1), RAC2(2), RAF1(6), RDX(2), RHOA(4), ROCK1(19), ROCK2(9), RRAS(1), RRAS2(3), SCIN(6), SLC9A1(6), SOS1(17), SOS2(13), SSH1(9), SSH2(9), SSH3(9), TIAM1(59), TIAM2(22), VAV1(8), VAV2(8), VAV3(32), VCL(8), WAS(8), WASF1(10), WASF2(3), WASL(7)	220926006	2186	497	1918	586	242	912	453	197	375	7	3.79e-05	1.000	1.000
135	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	168	ADCY1(26), ADCY2(51), ADCY3(7), ADCY4(12), ADCY7(13), ADCY8(48), ADCY9(12), ADORA2A(3), ADORA2B(1), ADRA1A(7), ADRA1B(8), ADRA1D(8), ADRB1(1), ADRB2(4), ADRB3(6), AGTR1(9), ATP2A1(9), ATP2A2(12), ATP2A3(7), ATP2B1(10), ATP2B2(28), ATP2B3(28), ATP2B4(13), AVPR1A(14), AVPR1B(7), BDKRB1(1), BDKRB2(3), BST1(3), CACNA1A(32), CACNA1B(39), CACNA1C(61), CACNA1D(21), CACNA1E(111), CACNA1F(30), CACNA1G(27), CACNA1H(21), CACNA1I(31), CACNA1S(23), CALM1(3), CALM2(1), CALML3(3), CALML6(1), CAMK2A(3), CAMK2B(16), CAMK2D(7), CAMK4(16), CCKAR(14), CCKBR(24), CD38(4), CHRM1(5), CHRM2(39), CHRM3(27), CHRM5(6), CHRNA7(3), CYSLTR1(5), CYSLTR2(12), DRD1(13), EDNRA(3), EDNRB(16), EGFR(86), ERBB2(12), ERBB3(11), ERBB4(51), F2R(10), GNA11(4), GNA14(2), GNA15(1), GNAL(5), GNAQ(5), GNAS(29), GRIN1(9), GRIN2A(61), GRIN2C(8), GRIN2D(9), GRM1(48), GRM5(40), GRPR(7), HRH1(5), HRH2(17), HTR2A(6), HTR2B(5), HTR2C(8), HTR4(6), HTR5A(21), HTR6(10), HTR7(11), ITPKA(2), ITPKB(7), ITPR1(20), ITPR2(40), ITPR3(21), LHCGR(14), MYLK(26), MYLK2(9), NOS1(29), NOS3(12), NTSR1(10), OXTR(4), P2RX1(6), P2RX2(6), P2RX3(4), P2RX5(12), P2RX7(6), PDE1A(17), PDE1B(13), PDE1C(28), PDGFRA(41), PDGFRB(18), PHKA1(16), PHKA2(14), PHKB(10), PHKG1(5), PHKG2(4), PLCB1(52), PLCB2(12), PLCB3(9), PLCB4(35), PLCD1(4), PLCD3(2), PLCD4(7), PLCE1(28), PLCG1(7), PLCG2(18), PLCZ1(8), PLN(1), PPID(2), PPP3CA(14), PPP3CB(3), PPP3CC(3), PPP3R1(5), PRKACA(3), PRKACB(9), PRKACG(4), PRKCA(10), PRKCG(20), PRKX(3), PTAFR(5), PTGER3(9), PTGFR(12), PTK2B(14), RYR1(111), RYR2(359), RYR3(124), SLC25A5(3), SLC25A6(5), SLC8A1(55), SLC8A2(10), SLC8A3(28), SPHK2(4), TACR1(4), TACR2(2), TACR3(15), TBXA2R(1), TNNC1(1), TNNC2(2), TRHR(14), TRPC1(10), VDAC1(2), VDAC2(2), VDAC3(1)	215110975	2901	486	2806	934	437	1165	582	265	434	18	0.00591	1.000	1.000
136	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	127	ABL1(9), ABLIM1(4), ABLIM2(4), ABLIM3(18), ARHGEF12(24), CDC42(1), CDK5(3), CFL2(3), CXCL12(3), CXCR4(6), DCC(41), DPYSL2(3), DPYSL5(10), EFNA2(1), EFNA3(2), EFNB1(2), EFNB2(4), EFNB3(1), EPHA1(9), EPHA2(10), EPHA3(56), EPHA4(18), EPHA5(78), EPHA6(59), EPHA7(40), EPHA8(21), EPHB1(44), EPHB2(10), EPHB3(14), EPHB4(10), EPHB6(53), FES(1), FYN(8), GNAI1(10), GNAI3(2), GSK3B(4), HRAS(2), ITGB1(6), KRAS(169), L1CAM(42), LIMK1(3), LIMK2(3), LRRC4C(53), MAPK1(2), MAPK3(3), MET(22), NCK1(5), NCK2(6), NFAT5(13), NFATC1(9), NFATC2(15), NFATC3(15), NFATC4(11), NGEF(12), NRAS(4), NRP1(9), NTN1(1), NTN4(6), NTNG1(33), PAK1(9), PAK2(3), PAK3(16), PAK4(6), PAK6(2), PAK7(37), PLXNA1(16), PLXNA2(30), PLXNA3(20), PLXNB1(12), PLXNB2(21), PLXNB3(15), PLXNC1(11), PPP3CA(14), PPP3CB(3), PPP3CC(3), PPP3R1(5), PTK2(6), RAC2(2), RASA1(11), RGS3(11), RHOA(4), RHOD(2), ROBO1(31), ROBO2(54), ROBO3(19), ROCK1(19), ROCK2(9), SEMA3A(26), SEMA3C(15), SEMA3D(33), SEMA3E(15), SEMA3F(7), SEMA3G(6), SEMA4A(5), SEMA4C(7), SEMA4D(8), SEMA4F(12), SEMA4G(3), SEMA5A(59), SEMA5B(30), SEMA6A(20), SEMA6B(12), SEMA6C(10), SEMA6D(40), SEMA7A(9), SLIT1(21), SLIT2(61), SLIT3(41), SRGAP1(20), SRGAP2(7), SRGAP3(24), UNC5A(18), UNC5B(19), UNC5C(22), UNC5D(45)	156945236	2016	463	1818	549	260	907	355	160	327	7	5.97e-07	1.000	1.000
137	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	236	ADCYAP1R1(17), ADORA1(9), ADORA2A(3), ADORA2B(1), ADORA3(4), ADRA1A(7), ADRA1B(8), ADRA2A(3), ADRA2B(4), ADRA2C(3), ADRB1(1), ADRB2(4), ADRB3(6), AGTR1(9), AGTR2(6), AVPR1A(14), AVPR1B(7), AVPR2(7), BDKRB1(1), BDKRB2(3), BRS3(8), C3AR1(11), C5AR1(7), CALCR(27), CALCRL(18), CCKAR(14), CCKBR(24), CGA(2), CHRM1(5), CHRM2(39), CHRM3(27), CHRM4(8), CHRM5(6), CNR1(15), CNR2(3), CRHR1(7), CTSG(12), CYSLTR1(5), CYSLTR2(12), DRD1(13), DRD2(26), DRD3(19), DRD4(2), DRD5(26), EDNRA(3), EDNRB(16), F2(9), F2R(10), F2RL1(2), F2RL2(12), F2RL3(2), FPR1(10), FSHB(4), FSHR(37), GABBR1(8), GABBR2(13), GABRA1(20), GABRA2(31), GABRA3(15), GABRA4(39), GABRA5(27), GABRA6(28), GABRB1(21), GABRB2(10), GABRB3(37), GABRD(8), GABRE(6), GABRG1(34), GABRG2(36), GABRG3(28), GABRP(6), GABRQ(23), GABRR1(11), GABRR2(10), GALR1(8), GALR2(3), GALR3(1), GH1(7), GH2(7), GHR(19), GHRHR(5), GHSR(5), GIPR(3), GLP1R(11), GLP2R(17), GLRA1(10), GLRA2(22), GLRA3(9), GLRB(9), GNRHR(5), GPR156(16), GPR35(8), GPR50(21), GPR63(10), GPR83(12), GRIA1(18), GRIA2(28), GRIA3(24), GRIA4(25), GRID1(30), GRID2(54), GRIK1(31), GRIK2(41), GRIK3(22), GRIK4(25), GRIK5(15), GRIN1(9), GRIN2A(61), GRIN2B(53), GRIN2C(8), GRIN2D(9), GRIN3A(38), GRIN3B(6), GRM1(48), GRM2(7), GRM3(19), GRM4(21), GRM5(40), GRM6(17), GRM7(43), GRM8(52), GRPR(7), GZMA(8), HCRTR1(4), HCRTR2(24), HRH1(5), HRH2(17), HRH3(7), HRH4(5), HTR1A(24), HTR1B(7), HTR1D(5), HTR1E(23), HTR1F(10), HTR2A(6), HTR2B(5), HTR2C(8), HTR4(6), HTR5A(21), HTR6(10), HTR7(11), LEP(4), LEPR(26), LHB(3), LHCGR(14), LTB4R(5), MAS1(5), MC1R(2), MC2R(12), MC3R(16), MC4R(3), MC5R(22), MCHR1(4), MCHR2(16), MLNR(2), MTNR1A(15), MTNR1B(13), NMBR(8), NMUR1(9), NMUR2(23), NPBWR1(5), NPBWR2(8), NPFFR1(2), NPFFR2(22), NPY1R(17), NPY2R(20), NPY5R(22), NR3C1(8), NTSR1(10), NTSR2(6), OPRD1(2), OPRK1(12), OPRL1(14), OPRM1(12), OXTR(4), P2RX1(6), P2RX2(6), P2RX3(4), P2RX5(12), P2RX7(6), P2RY1(4), P2RY10(23), P2RY11(2), P2RY13(1), P2RY14(2), P2RY2(3), P2RY4(4), P2RY6(2), P2RY8(9), PARD3(15), PRL(3), PRLHR(9), PRLR(18), PRSS1(25), PRSS3(1), PTAFR(5), PTGDR(8), PTGER2(4), PTGER3(9), PTGER4(7), PTGFR(12), PTGIR(6), PTH2R(15), RXFP1(20), RXFP2(8), SCTR(5), SSTR1(9), SSTR2(4), SSTR3(8), SSTR4(15), SSTR5(6), TAAR1(5), TAAR2(9), TAAR5(11), TAAR6(15), TAAR8(9), TACR1(4), TACR2(2), TACR3(15), TBXA2R(1), THRA(5), THRB(4), TRHR(14), TRPV1(5), TSHB(5), TSHR(22), UTS2R(4), VIPR1(2), VIPR2(3)	177489602	2931	458	2896	1017	395	1280	597	258	392	9	0.0324	1.000	1.000
138	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	92	ADCY1(26), ADCY2(51), ADCY3(7), ADCY4(12), ADCY5(27), ADCY6(10), ADCY7(13), ADCY8(48), ADCY9(12), ADRB1(1), CSNK1D(7), DRD1(13), DRD2(26), EGF(13), EGFR(86), GJA1(11), GJD2(6), GNA11(4), GNAI1(10), GNAI3(2), GNAQ(5), GNAS(29), GRB2(6), GRM1(48), GRM5(40), GUCY1A2(28), GUCY1A3(16), GUCY1B3(10), GUCY2C(11), GUCY2D(5), GUCY2F(28), HRAS(2), HTR2A(6), HTR2B(5), HTR2C(8), ITPR1(20), ITPR2(40), ITPR3(21), KRAS(169), MAP2K1(10), MAP2K2(1), MAP2K5(4), MAP3K2(6), MAPK1(2), MAPK3(3), MAPK7(7), NPR1(16), NPR2(6), NRAS(4), PDGFA(5), PDGFB(2), PDGFC(3), PDGFD(9), PDGFRA(41), PDGFRB(18), PLCB1(52), PLCB2(12), PLCB3(9), PLCB4(35), PRKACA(3), PRKACB(9), PRKACG(4), PRKCA(10), PRKCG(20), PRKG1(20), PRKG2(15), PRKX(3), RAF1(6), SOS1(17), SOS2(13), SRC(2), TJP1(15), TUBA1A(4), TUBA1B(3), TUBA1C(4), TUBA3C(28), TUBA3D(13), TUBA3E(9), TUBA4A(3), TUBA8(1), TUBAL3(3), TUBB(2), TUBB1(6), TUBB2A(3), TUBB2B(4), TUBB3(3), TUBB6(3), TUBB8(17)	105965928	1370	454	1149	359	156	588	274	136	212	4	2.22e-05	1.000	1.000
139	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	144	APC(33), APC2(8), AXIN1(7), AXIN2(5), BTRC(12), CACYBP(1), CAMK2A(3), CAMK2B(16), CAMK2D(7), CCND1(3), CCND2(4), CCND3(1), CER1(7), CHD8(29), CREBBP(30), CSNK1A1(2), CSNK1A1L(14), CSNK1E(6), CSNK2A1(5), CSNK2A2(2), CTBP1(2), CTNNB1(20), CUL1(14), CXXC4(2), DAAM1(8), DAAM2(4), DKK1(3), DKK2(14), DKK4(2), DVL1(5), DVL2(7), DVL3(13), EP300(11), FBXW11(2), FOSL1(4), FZD1(6), FZD10(26), FZD2(8), FZD3(2), FZD4(5), FZD5(5), FZD6(3), FZD7(7), FZD8(6), FZD9(4), GSK3B(4), JUN(3), LEF1(12), LRP5(17), LRP6(16), MAP3K7(10), MAPK10(6), MAPK8(2), MAPK9(8), MMP7(7), MYC(4), NFAT5(13), NFATC1(9), NFATC2(15), NFATC3(15), NFATC4(11), NKD1(6), NKD2(8), NLK(3), PLCB1(52), PLCB2(12), PLCB3(9), PLCB4(35), PORCN(7), PPARD(6), PPP2CA(1), PPP2CB(3), PPP2R1A(10), PPP2R1B(5), PPP2R2A(8), PPP2R2B(12), PPP2R2C(5), PPP3CA(14), PPP3CB(3), PPP3CC(3), PPP3R1(5), PRICKLE1(11), PRICKLE2(9), PRKACA(3), PRKACB(9), PRKACG(4), PRKCA(10), PRKCG(20), PRKX(3), PSEN1(6), RAC2(2), RHOA(4), ROCK1(19), ROCK2(9), RUVBL1(4), SENP2(6), SFRP1(2), SFRP2(6), SFRP4(7), SFRP5(1), SIAH1(1), SKP1(4), SMAD2(7), SMAD3(6), SMAD4(21), SOX17(1), TBL1X(5), TBL1XR1(6), TBL1Y(1), TCF7(3), TCF7L1(6), TCF7L2(7), TP53(309), VANGL1(9), VANGL2(15), WIF1(3), WNT1(6), WNT10A(10), WNT10B(10), WNT11(6), WNT16(9), WNT2(7), WNT2B(4), WNT3A(10), WNT4(1), WNT5A(2), WNT5B(6), WNT7A(14), WNT7B(4), WNT8A(9), WNT8B(8), WNT9A(6), WNT9B(6)	128954943	1394	447	1240	317	222	484	241	134	308	5	6.28e-09	1.000	1.000
140	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	131	ACTB(10), ACTG1(6), ACTN1(7), ACTN2(43), ACTN4(6), AKT1(3), AKT2(7), AKT3(7), AMOTL1(11), ASH1L(33), CASK(8), CDC42(1), CDK4(3), CGN(12), CLDN1(1), CLDN10(7), CLDN11(4), CLDN14(6), CLDN15(1), CLDN16(8), CLDN17(10), CLDN18(5), CLDN2(5), CLDN20(2), CLDN22(1), CLDN4(3), CLDN6(2), CLDN8(6), CLDN9(2), CSNK2A1(5), CSNK2A2(2), CTNNA1(9), CTNNA2(65), CTNNA3(22), CTNNB1(20), CTTN(6), EPB41(2), EPB41L1(10), EPB41L2(16), EPB41L3(31), EXOC3(3), EXOC4(16), F11R(3), GNAI1(10), GNAI3(2), HCLS1(17), HRAS(2), IGSF5(6), INADL(20), JAM2(9), JAM3(4), KRAS(169), LLGL1(6), LLGL2(9), MAGI1(21), MAGI2(33), MAGI3(10), MLLT4(12), MPDZ(20), MPP5(2), MRAS(1), MYH1(70), MYH10(14), MYH11(29), MYH13(47), MYH14(9), MYH15(31), MYH2(77), MYH3(37), MYH4(53), MYH6(42), MYH7(59), MYH7B(10), MYH8(73), MYH9(19), MYL2(8), MYL5(2), MYL7(4), MYL9(3), NRAS(4), OCLN(1), PARD3(15), PARD6A(1), PARD6B(4), PARD6G(2), PPM1J(2), PPP2CA(1), PPP2CB(3), PPP2R1A(10), PPP2R1B(5), PPP2R2A(8), PPP2R2B(12), PPP2R2C(5), PPP2R3A(2), PPP2R3B(6), PPP2R4(1), PRKCA(10), PRKCD(7), PRKCE(5), PRKCG(20), PRKCH(6), PRKCI(11), PRKCQ(12), PRKCZ(4), PTEN(11), RAB13(1), RAB3B(1), RHOA(4), RRAS(1), RRAS2(3), SPTAN1(21), SRC(2), SYMPK(16), TJAP1(4), TJP1(15), TJP2(6), TJP3(6), VAPA(2), YES1(3), ZAK(7)	155527927	1630	447	1450	431	194	721	339	127	245	4	4.09e-05	1.000	1.000
141	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	136	ACTB(10), ACTG1(6), CHAD(1), COL11A1(138), COL11A2(21), COL17A1(16), COL1A1(21), COL1A2(41), COL2A1(24), COL3A1(67), COL4A1(36), COL4A2(40), COL4A4(22), COL4A6(28), COL5A1(42), COL5A2(57), COL5A3(29), COL6A1(11), COL6A2(21), COL6A3(80), COL6A6(45), COMP(4), DES(4), DSC1(16), DSC2(24), DSC3(21), DSG1(29), DSG2(12), DSG3(37), DSG4(28), FN1(25), GJA1(11), GJA10(15), GJA3(3), GJA4(6), GJA5(7), GJA8(18), GJA9(12), GJB1(3), GJB2(1), GJB3(2), GJB4(10), GJB5(6), GJB6(2), GJB7(6), GJC1(8), GJC2(5), GJC3(4), GJD2(6), GJD4(3), IBSP(9), INA(4), ITGA6(12), ITGB4(10), KRT1(11), KRT10(6), KRT12(8), KRT13(5), KRT14(11), KRT15(4), KRT16(8), KRT17(9), KRT19(6), KRT2(11), KRT20(5), KRT23(7), KRT24(9), KRT25(11), KRT27(3), KRT28(11), KRT3(9), KRT31(14), KRT32(3), KRT33A(7), KRT33B(7), KRT34(15), KRT35(11), KRT36(9), KRT37(14), KRT38(15), KRT39(5), KRT4(9), KRT40(7), KRT5(14), KRT6A(14), KRT6B(19), KRT6C(5), KRT7(9), KRT71(12), KRT72(14), KRT73(10), KRT74(11), KRT75(11), KRT76(4), KRT77(6), KRT78(6), KRT79(12), KRT8(3), KRT81(2), KRT82(12), KRT83(9), KRT84(5), KRT85(5), KRT86(1), KRT9(5), LAMA1(63), LAMA2(81), LAMA3(36), LAMA4(40), LAMA5(33), LAMB1(40), LAMB2(21), LAMB3(19), LAMB4(52), LAMC1(27), LAMC2(11), LAMC3(25), LMNA(2), LMNB1(5), LMNB2(5), NES(33), PRPH(1), RELN(104), SPP1(5), THBS1(8), THBS2(35), THBS3(5), THBS4(8), TNC(26), TNN(87), TNR(112), TNXB(32), VIM(5), VTN(4), VWF(32)	199332373	2515	443	2489	781	316	1113	472	163	438	13	0.0867	1.000	1.000
142	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	95	ADCY1(26), ADCY2(51), ADCY3(7), ADCY4(12), ADCY5(27), ADCY6(10), ADCY7(13), ADCY8(48), ADCY9(12), ATF4(2), CACNA1C(61), CACNA1D(21), CACNA1F(30), CACNA1S(23), CALM1(3), CALM2(1), CALML3(3), CALML6(1), CAMK2A(3), CAMK2B(16), CAMK2D(7), CDC42(1), CGA(2), EGFR(86), ELK1(3), FSHB(4), GNA11(4), GNAQ(5), GNAS(29), GNRH1(1), GNRHR(5), GRB2(6), HRAS(2), ITPR1(20), ITPR2(40), ITPR3(21), JUN(3), KRAS(169), LHB(3), MAP2K1(10), MAP2K2(1), MAP2K3(13), MAP2K4(8), MAP2K6(5), MAP2K7(7), MAP3K1(7), MAP3K2(6), MAP3K3(10), MAP3K4(21), MAPK1(2), MAPK10(6), MAPK12(2), MAPK13(1), MAPK14(4), MAPK3(3), MAPK7(7), MAPK8(2), MAPK9(8), MMP14(4), MMP2(24), NRAS(4), PLA2G12A(4), PLA2G12B(3), PLA2G1B(2), PLA2G2A(5), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(6), PLA2G4A(21), PLA2G6(3), PLCB1(52), PLCB2(12), PLCB3(9), PLCB4(35), PLD1(19), PLD2(7), PRKACA(3), PRKACB(9), PRKACG(4), PRKCA(10), PRKCD(7), PRKX(3), PTK2B(14), RAF1(6), SOS1(17), SOS2(13), SRC(2)	101702499	1208	441	987	321	156	516	230	109	196	1	0.000146	1.000	1.000
143	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	249	ACVR1(7), ACVR1B(11), ACVR2A(5), ACVR2B(4), AMHR2(6), BMP2(1), BMP7(12), BMPR1A(4), BMPR1B(7), BMPR2(10), CCL1(4), CCL11(2), CCL13(3), CCL14(3), CCL15(5), CCL16(4), CCL17(3), CCL18(2), CCL19(1), CCL2(2), CCL20(3), CCL21(2), CCL22(1), CCL23(3), CCL24(1), CCL25(2), CCL28(6), CCL4(2), CCL7(5), CCL8(1), CCR1(3), CCR2(6), CCR3(4), CCR4(3), CCR5(4), CCR6(9), CCR8(6), CD27(1), CD40(3), CD40LG(9), CD70(1), CNTF(6), CNTFR(5), CRLF2(9), CSF1(1), CSF1R(18), CSF2RA(8), CSF2RB(14), CSF3R(6), CX3CL1(5), CX3CR1(11), CXCL1(1), CXCL10(1), CXCL11(1), CXCL12(3), CXCL14(1), CXCL2(1), CXCL6(3), CXCL9(4), CXCR3(3), CXCR4(6), CXCR6(2), EDA(4), EDA2R(9), EDAR(8), EGF(13), EGFR(86), EPO(6), EPOR(2), FAS(4), FASLG(10), FLT1(31), FLT3(24), FLT3LG(2), FLT4(20), GDF5(12), GH1(7), GH2(7), GHR(19), HGF(54), IFNA1(2), IFNA10(7), IFNA14(4), IFNA16(8), IFNA17(5), IFNA2(5), IFNA21(3), IFNA4(4), IFNA5(5), IFNA6(7), IFNA7(6), IFNA8(7), IFNAR1(4), IFNAR2(7), IFNB1(7), IFNG(7), IFNGR1(7), IFNGR2(4), IFNK(1), IFNW1(2), IL10(2), IL10RA(6), IL10RB(6), IL11RA(1), IL12A(2), IL12B(3), IL12RB1(5), IL12RB2(15), IL13(2), IL13RA1(3), IL15(6), IL15RA(2), IL17A(12), IL17B(2), IL17RA(4), IL18R1(12), IL18RAP(22), IL19(2), IL1A(4), IL1B(1), IL1R1(2), IL1R2(5), IL1RAP(4), IL2(7), IL20(2), IL20RA(5), IL21(2), IL21R(14), IL22(4), IL22RA1(7), IL22RA2(6), IL23R(6), IL24(3), IL25(2), IL26(3), IL2RA(6), IL2RB(7), IL2RG(5), IL3(4), IL3RA(8), IL4(1), IL4R(10), IL5(2), IL5RA(9), IL6(2), IL6R(8), IL6ST(3), IL7(2), IL7R(21), IL9(1), IL9R(16), INHBA(31), INHBB(4), INHBC(4), INHBE(5), KDR(56), KIT(12), KITLG(6), LEP(4), LEPR(26), LIF(3), LIFR(14), LTA(3), LTB(4), LTBR(1), MET(22), MPL(5), NGFR(5), OSM(5), OSMR(7), PDGFB(2), PDGFC(3), PDGFRA(41), PDGFRB(18), PF4(1), PF4V1(2), PLEKHO2(3), PPBP(2), PRL(3), PRLR(18), TGFB1(3), TGFB2(10), TGFBR1(7), TGFBR2(7), TNF(2), TNFRSF10B(3), TNFRSF10C(1), TNFRSF10D(2), TNFRSF11A(9), TNFRSF11B(3), TNFRSF12A(2), TNFRSF13B(3), TNFRSF13C(2), TNFRSF14(1), TNFRSF18(2), TNFRSF19(5), TNFRSF1B(2), TNFRSF21(3), TNFRSF25(2), TNFRSF4(4), TNFRSF6B(1), TNFRSF8(11), TNFRSF9(7), TNFSF10(3), TNFSF11(5), TNFSF12(1), TNFSF13B(1), TNFSF14(2), TNFSF15(3), TNFSF18(5), TNFSF4(2), TNFSF8(1), TNFSF9(3), TPO(33), TSLP(8), VEGFA(1), VEGFB(2), VEGFC(21), XCL1(7), XCL2(5), XCR1(6)	142290090	1500	434	1433	426	148	606	292	180	272	2	0.0213	1.000	1.000
144	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(26), ADCY2(51), ADCY3(7), ADCY4(12), ADCY5(27), ADCY6(10), ADCY7(13), ADCY8(48), ADCY9(12), ADRA1A(7), ADRA1B(8), ADRA1D(8), ADRB1(1), ADRB2(4), ADRB3(6), ANXA6(8), ARRB1(2), ARRB2(4), ATP1A4(19), ATP1B1(6), ATP1B2(1), ATP1B3(2), ATP2A2(12), ATP2A3(7), ATP2B1(10), ATP2B2(28), ATP2B3(28), CACNA1A(32), CACNA1B(39), CACNA1C(61), CACNA1D(21), CACNA1E(111), CACNA1S(23), CACNB1(5), CACNB3(1), CALM1(3), CALM2(1), CALR(2), CAMK1(1), CAMK2A(3), CAMK2B(16), CAMK2D(7), CAMK4(16), CASQ1(6), CASQ2(5), CHRM1(5), CHRM2(39), CHRM3(27), CHRM4(8), CHRM5(6), FXYD2(1), GJA1(11), GJA4(6), GJA5(7), GJB1(3), GJB2(1), GJB3(2), GJB4(10), GJB5(6), GJB6(2), GNA11(4), GNAI3(2), GNAO1(7), GNAQ(5), GNAZ(5), GNB1(2), GNB3(5), GNB4(3), GNB5(7), GNG12(3), GNG13(5), GNG2(6), GNG3(1), GNG4(1), GNG7(1), GNGT1(6), GRK4(5), GRK5(10), GRK6(1), ITPR1(20), ITPR2(40), ITPR3(21), KCNB1(28), KCNJ3(36), KCNJ5(10), MIB1(12), NME7(4), PEA15(1), PKIA(1), PKIB(1), PKIG(1), PLCB3(9), PLN(1), PRKACA(3), PRKACB(9), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PRKCA(10), PRKCD(7), PRKCE(5), PRKCG(20), PRKCH(6), PRKCQ(12), PRKCZ(4), PRKD1(31), RGS1(14), RGS10(3), RGS11(3), RGS14(4), RGS16(3), RGS18(14), RGS19(2), RGS2(5), RGS20(8), RGS3(11), RGS4(6), RGS5(7), RGS6(14), RGS7(33), RGS9(16), RYR1(111), RYR2(359), RYR3(124), SFN(1), SLC8A1(55), SLC8A3(28), USP5(8), YWHAB(1), YWHAH(1), YWHAQ(4)	150352635	2071	430	2040	679	301	868	426	177	282	17	0.0447	1.000	1.000
145	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(16), CD36(4), CD44(7), CD47(6), CHAD(1), COL11A1(138), COL11A2(21), COL1A1(21), COL1A2(41), COL2A1(24), COL3A1(67), COL4A1(36), COL4A2(40), COL4A4(22), COL4A6(28), COL5A1(42), COL5A2(57), COL5A3(29), COL6A1(11), COL6A2(21), COL6A3(80), COL6A6(45), DAG1(3), FN1(25), FNDC1(33), FNDC3A(9), FNDC4(1), FNDC5(1), GP5(8), GP6(6), HMMR(6), HSPG2(33), IBSP(9), ITGA1(14), ITGA10(16), ITGA11(12), ITGA2(25), ITGA2B(12), ITGA3(8), ITGA4(38), ITGA5(11), ITGA6(12), ITGA7(13), ITGA8(59), ITGA9(6), ITGAV(14), ITGB1(6), ITGB3(13), ITGB4(10), ITGB5(4), ITGB6(11), ITGB7(2), ITGB8(15), LAMA1(63), LAMA2(81), LAMA3(36), LAMA4(40), LAMA5(33), LAMB1(40), LAMB2(21), LAMB3(19), LAMB4(52), LAMC1(27), LAMC2(11), LAMC3(25), RELN(104), SDC1(4), SDC2(1), SDC3(3), SDC4(2), SPP1(5), SV2A(17), SV2B(14), SV2C(20), THBS1(8), THBS2(35), THBS3(5), THBS4(8), TNC(26), TNN(87), TNR(112), TNXB(32), VTN(4), VWF(32)	178940152	2159	430	2140	622	247	976	413	124	385	14	0.0111	1.000	1.000
146	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	85	ABL1(9), ABL2(18), AKT1(3), AKT2(7), AKT3(7), ARAF(5), AREG(1), BRAF(44), BTC(2), CAMK2A(3), CAMK2B(16), CAMK2D(7), CBL(10), CBLB(10), CBLC(1), CDKN1A(2), CDKN1B(5), CRK(1), CRKL(4), EGF(13), EGFR(86), ELK1(3), ERBB2(12), ERBB3(11), ERBB4(51), EREG(4), GAB1(7), GRB2(6), GSK3B(4), HRAS(2), JUN(3), KRAS(169), MAP2K1(10), MAP2K2(1), MAP2K4(8), MAP2K7(7), MAPK1(2), MAPK10(6), MAPK3(3), MAPK8(2), MAPK9(8), MYC(4), NCK1(5), NCK2(6), NRAS(4), NRG1(18), NRG2(3), NRG3(31), NRG4(1), PAK1(9), PAK2(3), PAK3(16), PAK4(6), PAK6(2), PAK7(37), PIK3CA(30), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PLCG1(7), PLCG2(18), PRKCA(10), PRKCG(20), PTK2(6), RAF1(6), RPS6KB1(3), RPS6KB2(3), SHC1(6), SHC2(5), SHC3(8), SHC4(7), SOS1(17), SOS2(13), SRC(2), STAT5A(3), STAT5B(8), TGFA(1)	82290086	969	428	707	207	103	431	183	93	157	2	3.78e-07	1.000	1.000
147	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	67	ADCY1(26), ADCY8(48), ARAF(5), ATF4(2), BRAF(44), CACNA1C(61), CALM1(3), CALM2(1), CALML3(3), CALML6(1), CAMK2A(3), CAMK2B(16), CAMK2D(7), CAMK4(16), CREBBP(30), EP300(11), GNAQ(5), GRIA1(18), GRIA2(28), GRIN1(9), GRIN2A(61), GRIN2B(53), GRIN2C(8), GRIN2D(9), GRM1(48), GRM5(40), HRAS(2), ITPR1(20), ITPR2(40), ITPR3(21), KRAS(169), MAP2K1(10), MAP2K2(1), MAPK1(2), MAPK3(3), NRAS(4), PLCB1(52), PLCB2(12), PLCB3(9), PLCB4(35), PPP1CA(2), PPP1CB(4), PPP1CC(1), PPP1R12A(8), PPP1R1A(2), PPP3CA(14), PPP3CB(3), PPP3CC(3), PPP3R1(5), PRKACA(3), PRKACB(9), PRKACG(4), PRKCA(10), PRKCG(20), PRKX(3), RAF1(6), RAP1A(1), RAP1B(2), RAPGEF3(7), RPS6KA1(6), RPS6KA2(8), RPS6KA3(6), RPS6KA6(18)	79663693	1081	425	886	258	128	520	220	70	139	4	9.96e-08	1.000	1.000
148	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	109	ABL1(9), ANAPC1(12), ANAPC10(1), ANAPC11(1), ANAPC2(5), ANAPC4(6), ANAPC5(8), ANAPC7(5), ATM(53), ATR(26), BUB1(10), BUB1B(10), BUB3(4), CCNA1(7), CCNA2(6), CCNB1(2), CCNB3(35), CCND1(3), CCND2(4), CCND3(1), CCNE1(7), CCNE2(3), CCNH(3), CDC14A(10), CDC14B(3), CDC16(2), CDC20(8), CDC23(3), CDC25A(4), CDC25B(1), CDC25C(8), CDC27(7), CDC6(4), CDC7(6), CDK2(1), CDK4(3), CDK6(5), CDK7(3), CDKN1A(2), CDKN1B(5), CDKN2A(22), CDKN2D(2), CHEK1(7), CHEK2(10), CREBBP(30), CUL1(14), DBF4(6), E2F1(3), E2F2(5), E2F3(2), EP300(11), ESPL1(6), FZR1(3), GADD45A(2), GADD45B(1), GADD45G(1), GSK3B(4), HDAC1(4), HDAC2(8), MAD1L1(6), MAD2L1(5), MAD2L2(2), MCM2(5), MCM3(12), MCM4(11), MCM5(10), MCM6(16), MCM7(5), MDM2(5), PCNA(1), PKMYT1(3), PLK1(9), PRKDC(50), PTTG1(2), RB1(33), RBL1(7), RBL2(5), SFN(1), SKP1(4), SKP2(3), SMAD2(7), SMAD3(6), SMAD4(21), SMC1A(9), SMC1B(8), TFDP1(10), TGFB1(3), TGFB2(10), TP53(309), WEE1(4), YWHAB(1), YWHAE(1), YWHAG(3), YWHAH(1), YWHAQ(4), YWHAZ(2)	109028105	1031	419	888	155	136	294	180	119	296	6	<1.00e-15	1.000	1.000
149	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	130	ACACA(20), ACACB(28), AKT1(3), AKT2(7), AKT3(7), ARAF(5), BRAF(44), CALM1(3), CALM2(1), CALML3(3), CALML6(1), CBL(10), CBLB(10), CBLC(1), CRK(1), CRKL(4), ELK1(3), EXOC7(4), FASN(18), FBP1(2), FBP2(2), FLOT1(1), FLOT2(4), FOXO1(5), G6PC(7), G6PC2(8), GCK(6), GRB2(6), GSK3B(4), GYS1(4), GYS2(8), HRAS(2), IKBKB(9), INPP5D(11), INSR(10), IRS1(20), IRS4(34), KRAS(169), LIPE(5), MAP2K1(10), MAP2K2(1), MAPK1(2), MAPK10(6), MAPK3(3), MAPK8(2), MAPK9(8), MKNK1(4), MKNK2(2), NRAS(4), PCK1(21), PCK2(4), PDE3A(30), PDE3B(16), PDPK1(3), PFKL(9), PFKM(7), PFKP(5), PHKA1(16), PHKA2(14), PHKB(10), PHKG1(5), PHKG2(4), PIK3CA(30), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PKLR(16), PPARGC1A(23), PPP1CA(2), PPP1CB(4), PPP1CC(1), PPP1R3A(48), PPP1R3B(1), PPP1R3C(3), PPP1R3D(5), PRKAA1(6), PRKAA2(8), PRKAB1(3), PRKACA(3), PRKACB(9), PRKACG(4), PRKAG1(1), PRKAG2(5), PRKAG3(8), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PRKCI(11), PRKCZ(4), PRKX(3), PTPN1(3), PTPRF(15), PYGB(5), PYGL(6), PYGM(9), RAF1(6), RAPGEF1(7), RHEB(4), RHOQ(1), RPS6(3), RPS6KB1(3), RPS6KB2(3), SH2B2(6), SHC1(6), SHC2(5), SHC3(8), SHC4(7), SLC2A4(4), SOCS2(3), SOCS4(1), SORBS1(12), SOS1(17), SOS2(13), SREBF1(3), TRIP10(2), TSC1(10), TSC2(13)	126813403	1138	419	935	319	140	510	241	93	150	4	0.00754	1.000	1.000
150	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	126	ARAF(5), BID(2), BRAF(44), CASP3(5), CD244(14), CD247(1), CD48(5), FAS(4), FASLG(10), FCER1G(2), FCGR3A(9), FYN(8), GRB2(6), GZMB(6), HCST(3), HLA-A(8), HLA-B(4), HLA-C(5), HLA-E(2), HLA-G(5), HRAS(2), ICAM1(2), ICAM2(2), IFNA1(2), IFNA10(7), IFNA14(4), IFNA16(8), IFNA17(5), IFNA2(5), IFNA21(3), IFNA4(4), IFNA5(5), IFNA6(7), IFNA7(6), IFNA8(7), IFNAR1(4), IFNAR2(7), IFNB1(7), IFNG(7), IFNGR1(7), IFNGR2(4), ITGAL(26), ITGB2(8), KIR2DL3(8), KIR3DL1(17), KIR3DL2(5), KLRC1(5), KLRC2(2), KLRC3(5), KLRD1(2), KLRK1(4), KRAS(169), LAT(4), LCK(9), LCP2(10), MAP2K1(10), MAP2K2(1), MAPK1(2), MAPK3(3), MICA(1), MICB(2), NCR1(9), NCR2(3), NCR3(1), NFAT5(13), NFATC1(9), NFATC2(15), NFATC3(15), NFATC4(11), NRAS(4), PAK1(9), PIK3CA(30), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PLCG1(7), PLCG2(18), PPP3CA(14), PPP3CB(3), PPP3CC(3), PPP3R1(5), PRF1(8), PRKCA(10), PRKCG(20), PTK2B(14), PTPN11(9), PTPN6(6), RAC2(2), RAF1(6), SH2D1A(3), SH2D1B(3), SH3BP2(10), SHC1(6), SHC2(5), SHC3(8), SHC4(7), SOS1(17), SOS2(13), SYK(5), TNF(2), TNFRSF10B(3), TNFRSF10C(1), TNFRSF10D(2), TNFSF10(3), TYROBP(2), ULBP1(2), ULBP2(3), ULBP3(3), VAV1(8), VAV2(8), VAV3(32), ZAP70(9)	90825368	1023	417	815	237	111	479	212	79	138	4	6.50e-07	1.000	1.000
151	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	ARAF(5), BRAF(44), CACNA1A(32), CRH(3), CRHR1(7), GNA11(4), GNA12(1), GNA13(6), GNAI1(10), GNAI3(2), GNAO1(7), GNAQ(5), GNAS(29), GNAZ(5), GRIA1(18), GRIA2(28), GRIA3(24), GRID2(54), GRM1(48), GRM5(40), GUCY1A2(28), GUCY1A3(16), GUCY1B3(10), GUCY2C(11), GUCY2D(5), GUCY2F(28), HRAS(2), IGF1(4), IGF1R(8), ITPR1(20), ITPR2(40), ITPR3(21), KRAS(169), LYN(6), MAP2K1(10), MAP2K2(1), MAPK1(2), MAPK3(3), NOS1(29), NOS3(12), NPR1(16), NPR2(6), NRAS(4), PLA2G12A(4), PLA2G12B(3), PLA2G1B(2), PLA2G2A(5), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(6), PLA2G4A(21), PLA2G6(3), PLCB1(52), PLCB2(12), PLCB3(9), PLCB4(35), PPP2CA(1), PPP2CB(3), PPP2R1A(10), PPP2R1B(5), PPP2R2A(8), PPP2R2B(12), PPP2R2C(5), PRKCA(10), PRKCG(20), PRKG1(20), PRKG2(15), RAF1(6), RYR1(111)	88226661	1207	411	1016	289	153	544	243	89	173	5	1.57e-08	1.000	1.000
152	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	82	ABL1(9), ATM(53), BUB1(10), BUB1B(10), BUB3(4), CCNA1(7), CCNA2(6), CCNB1(2), CCNB3(35), CCND2(4), CCND3(1), CCNE1(7), CCNE2(3), CCNH(3), CDAN1(8), CDC14A(10), CDC14B(3), CDC20(8), CDC25A(4), CDC25B(1), CDC25C(8), CDC6(4), CDC7(6), CDH1(6), CDK2(1), CDK4(3), CDKN1A(2), CDKN2A(22), CHEK1(7), CHEK2(10), DTX4(2), E2F1(3), E2F2(5), E2F3(2), E2F4(5), E2F5(1), E2F6(1), EP300(11), ESPL1(6), GADD45A(2), GSK3B(4), HDAC1(4), HDAC2(8), HDAC3(3), HDAC4(19), HDAC5(5), HDAC6(12), HDAC8(1), MAD1L1(6), MAD2L1(5), MAD2L2(2), MCM2(5), MCM3(12), MCM4(11), MCM5(10), MCM6(16), MCM7(5), MDM2(5), MPEG1(12), MPL(5), PCNA(1), PLK1(9), PRKDC(50), PTPRA(11), PTTG1(2), RB1(33), RBL1(7), SKP2(3), SMAD4(21), TBC1D8(9), TFDP1(10), TGFB1(3), TP53(309), WEE1(4)	88375531	917	405	774	132	112	267	147	102	283	6	<1.00e-15	1.000	1.000
153	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ACTA1(9), ACTA2(1), ADCY1(26), ADCY2(51), ADCY3(7), ADCY4(12), ADCY5(27), ADCY6(10), ADCY7(13), ADCY8(48), ADCY9(12), ADM(1), ARRB1(2), ARRB2(4), ATF1(1), ATF2(10), ATF4(2), ATF5(2), ATP2A2(12), ATP2A3(7), CACNB3(1), CALCA(7), CALM1(3), CALM2(1), CAMK2A(3), CAMK2B(16), CAMK2D(7), CNN1(5), CORIN(25), CRH(3), CRHR1(7), DGKZ(5), ETS2(6), FOS(3), GABPA(6), GABPB2(1), GBA2(5), GJA1(11), GNAQ(5), GNB1(2), GNB3(5), GNB4(3), GNB5(7), GNG12(3), GNG13(5), GNG2(6), GNG3(1), GNG4(1), GNG7(1), GNGT1(6), GRK4(5), GRK5(10), GRK6(1), GUCA2B(2), GUCY1A3(16), IGFBP1(6), IGFBP2(4), IGFBP3(4), IGFBP4(1), IGFBP6(1), IL1B(1), IL6(2), ITPR1(20), ITPR2(40), ITPR3(21), JUN(3), MIB1(12), MYL2(8), MYL4(2), MYLK2(9), NFKB1(6), NOS1(29), NOS3(12), OXT(2), OXTR(4), PDE4B(14), PDE4D(5), PKIA(1), PKIB(1), PKIG(1), PLCB3(9), PLCD1(4), PLCG1(7), PLCG2(18), PRKACA(3), PRKACB(9), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PRKCA(10), PRKCD(7), PRKCE(5), PRKCH(6), PRKCQ(12), PRKCZ(4), PRKD1(31), RAMP1(1), RAMP2(4), RAMP3(3), RGS1(14), RGS10(3), RGS11(3), RGS14(4), RGS16(3), RGS18(14), RGS19(2), RGS2(5), RGS20(8), RGS3(11), RGS4(6), RGS5(7), RGS6(14), RGS7(33), RGS9(16), RYR1(111), RYR2(359), RYR3(124), SFN(1), SLC8A1(55), SP1(6), TNXB(32), USP5(8), YWHAB(1), YWHAH(1), YWHAQ(4)	138778548	1649	405	1626	545	225	685	342	146	237	14	0.229	1.000	1.000
154	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	130	ALCAM(6), CADM1(7), CADM3(15), CD2(6), CD22(16), CD226(14), CD274(3), CD276(2), CD28(4), CD34(13), CD4(8), CD40(3), CD40LG(9), CD58(1), CD6(13), CD80(3), CD86(11), CD8A(4), CD8B(5), CD99(3), CDH1(6), CDH15(9), CDH2(35), CDH3(7), CDH4(23), CDH5(13), CLDN1(1), CLDN10(7), CLDN11(4), CLDN14(6), CLDN15(1), CLDN16(8), CLDN17(10), CLDN18(5), CLDN2(5), CLDN20(2), CLDN22(1), CLDN4(3), CLDN6(2), CLDN8(6), CLDN9(2), CNTN1(36), CNTN2(18), CNTNAP1(11), CNTNAP2(88), CTLA4(3), ESAM(2), F11R(3), GLG1(17), HLA-A(8), HLA-B(4), HLA-C(5), HLA-DMA(4), HLA-DMB(3), HLA-DOA(2), HLA-DPA1(1), HLA-DQA2(3), HLA-DQB1(4), HLA-DRA(3), HLA-DRB1(5), HLA-E(2), HLA-G(5), ICAM1(2), ICAM2(2), ICAM3(2), ICOS(5), ICOSLG(3), ITGA4(38), ITGA6(12), ITGA8(59), ITGA9(6), ITGAL(26), ITGAM(24), ITGAV(14), ITGB1(6), ITGB2(8), ITGB7(2), ITGB8(15), JAM2(9), JAM3(4), L1CAM(42), MADCAM1(2), MAG(7), MPZ(2), MPZL1(3), NCAM1(30), NCAM2(28), NEGR1(14), NEO1(12), NFASC(46), NLGN1(34), NLGN2(10), NLGN3(14), NRCAM(35), NRXN1(109), NRXN2(25), NRXN3(49), OCLN(1), PDCD1(4), PDCD1LG2(4), PTPRC(41), PTPRF(15), PTPRM(14), PVRL1(16), PVRL3(7), SDC1(4), SDC2(1), SDC3(3), SDC4(2), SELE(17), SELL(9), SELP(29), SELPLG(2), SIGLEC1(18), SPN(4), VCAM1(28), VCAN(104)	118538695	1551	402	1532	460	196	690	301	123	233	8	0.00651	1.000	1.000
155	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	92	AKT1(3), AKT2(7), AKT3(7), BCL10(4), CARD11(34), CBL(10), CBLB(10), CBLC(1), CD247(1), CD28(4), CD3D(2), CD3E(2), CD4(8), CD40LG(9), CD8A(4), CD8B(5), CDC42(1), CDK4(3), CHUK(7), CTLA4(3), FOS(3), FYN(8), GRAP2(13), GRB2(6), HRAS(2), ICOS(5), IFNG(7), IKBKB(9), IL10(2), IL2(7), IL4(1), IL5(2), ITK(16), JUN(3), KRAS(169), LAT(4), LCK(9), LCP2(10), MALT1(13), MAP3K8(4), NCK1(5), NCK2(6), NFAT5(13), NFATC1(9), NFATC2(15), NFATC3(15), NFATC4(11), NFKB1(6), NFKB2(5), NFKBIA(4), NFKBIB(3), NFKBIE(2), NRAS(4), PAK1(9), PAK2(3), PAK3(16), PAK4(6), PAK6(2), PAK7(37), PDCD1(4), PDK1(6), PIK3CA(30), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PLCG1(7), PPP3CA(14), PPP3CB(3), PPP3CC(3), PPP3R1(5), PRKCQ(12), PTPN6(6), PTPRC(41), RASGRP1(3), RHOA(4), SOS1(17), SOS2(13), TEC(12), TNF(2), VAV1(8), VAV2(8), VAV3(32), ZAP70(9)	81304899	906	402	722	202	109	433	166	60	136	2	1.31e-06	1.000	1.000
156	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	80	AIFM1(16), AKT1(3), AKT2(7), AKT3(7), APAF1(10), ATM(53), BAX(3), BCL2(5), BCL2L1(3), BID(2), BIRC2(2), BIRC3(4), CAPN1(2), CAPN2(5), CASP10(7), CASP3(5), CASP6(3), CASP7(3), CASP8(6), CASP9(6), CFLAR(2), CHUK(7), CSF2RB(14), CYCS(2), DFFA(3), DFFB(4), FADD(2), FAS(4), FASLG(10), IKBKB(9), IL1A(4), IL1B(1), IL1R1(2), IL1RAP(4), IL3(4), IL3RA(8), IRAK1(6), IRAK2(6), IRAK3(6), IRAK4(4), MYD88(1), NFKB1(6), NFKB2(5), NFKBIA(4), NTRK1(14), PIK3CA(30), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PPP3CA(14), PPP3CB(3), PPP3CC(3), PPP3R1(5), PRKACA(3), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), RELA(3), RIPK1(11), TNF(2), TNFRSF10B(3), TNFRSF10C(1), TNFRSF10D(2), TNFSF10(3), TP53(309), TRADD(2), TRAF2(5)	66856063	785	397	634	152	95	257	140	91	195	7	1.06e-07	1.000	1.000
157	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	99	ADCY1(26), ADCY2(51), ADCY3(7), ADCY4(12), ADCY5(27), ADCY6(10), ADCY7(13), ADCY8(48), ADCY9(12), ASIP(1), CALM1(3), CALM2(1), CALML3(3), CALML6(1), CAMK2A(3), CAMK2B(16), CAMK2D(7), CREB1(2), CREB3L1(4), CREB3L2(8), CREB3L3(3), CREB3L4(2), CREBBP(30), CTNNB1(20), DCT(16), DVL1(5), DVL2(7), DVL3(13), EDN1(1), EDNRB(16), EP300(11), FZD1(6), FZD10(26), FZD2(8), FZD3(2), FZD4(5), FZD5(5), FZD6(3), FZD7(7), FZD8(6), FZD9(4), GNAI1(10), GNAI3(2), GNAO1(7), GNAQ(5), GNAS(29), GSK3B(4), HRAS(2), KIT(12), KITLG(6), KRAS(169), LEF1(12), MAP2K1(10), MAP2K2(1), MAPK1(2), MAPK3(3), MC1R(2), MITF(3), NRAS(4), PLCB1(52), PLCB2(12), PLCB3(9), PLCB4(35), POMC(4), PRKACA(3), PRKACB(9), PRKACG(4), PRKCA(10), PRKCG(20), PRKX(3), RAF1(6), TCF7(3), TCF7L1(6), TCF7L2(7), TYR(29), TYRP1(5), WNT1(6), WNT10A(10), WNT10B(10), WNT11(6), WNT16(9), WNT2(7), WNT2B(4), WNT3A(10), WNT4(1), WNT5A(2), WNT5B(6), WNT7A(14), WNT7B(4), WNT8A(9), WNT8B(8), WNT9A(6), WNT9B(6)	86816850	1069	397	890	295	165	478	219	72	133	2	5.36e-05	1.000	1.000
158	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY1(26), ADCY2(51), ADCY3(7), ADCY4(12), ADCY5(27), ADCY6(10), ADCY7(13), ADCY8(48), ADCY9(12), AKAP1(14), AKAP10(4), AKAP11(14), AKAP12(9), AKAP2(11), AKAP3(15), AKAP4(17), AKAP5(2), AKAP6(45), AKAP7(1), AKAP8(5), AKAP9(32), ARHGEF1(5), CALM1(3), CALM2(1), CHMP1B(1), GNA11(4), GNA12(1), GNA13(6), GNA14(2), GNA15(1), GNAI3(2), GNAL(5), GNAO1(7), GNAQ(5), GNAZ(5), GNB1(2), GNB3(5), GNB5(7), GNG12(3), GNG13(5), GNG3(1), GNG4(1), GNG7(1), GNGT1(6), GNGT2(3), HRAS(2), IL18BP(1), ITPR1(20), KCNJ3(36), KRAS(169), NRAS(4), PALM2(7), PDE1A(17), PDE1B(13), PDE1C(28), PDE4A(7), PDE4B(14), PDE4C(4), PDE4D(5), PDE7A(3), PDE7B(6), PDE8A(3), PDE8B(10), PLCB3(9), PPP3CA(14), PPP3CC(3), PRKACA(3), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PRKCA(10), PRKCD(7), PRKCE(5), PRKCG(20), PRKCH(6), PRKCI(11), PRKCQ(12), PRKCZ(4), PRKD1(31), PRKD3(10), RHOA(4), RRAS(1), SLC9A1(6), USP5(8)	93920207	994	389	826	275	110	465	216	73	124	6	0.00452	1.000	1.000
159	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	162	ADORA1(9), ADORA2A(3), ADORA2B(1), ADORA3(4), ADRA1A(7), ADRA1B(8), ADRA1D(8), ADRA2A(3), ADRA2C(3), ADRB1(1), ADRB2(4), ADRB3(6), AGTR1(9), AGTR2(6), AVPR1A(14), AVPR1B(7), AVPR2(7), BDKRB1(1), BDKRB2(3), BRS3(8), C3AR1(11), CCKAR(14), CCKBR(24), CCR1(3), CCR10(1), CCR2(6), CCR3(4), CCR4(3), CCR5(4), CCR6(9), CCR8(6), CCRL2(2), CHML(12), CHRM1(5), CHRM2(39), CHRM3(27), CHRM4(8), CHRM5(6), CMKLR1(24), CNR1(15), CNR2(3), CX3CR1(11), CXCR3(3), CXCR4(6), DRD1(13), DRD2(26), DRD3(19), DRD4(2), DRD5(26), EDNRA(3), EDNRB(16), F2R(10), F2RL1(2), F2RL2(12), F2RL3(2), FPR1(10), FSHR(37), GALR1(8), GALR2(3), GALR3(1), GALT(5), GHSR(5), GNB2L1(3), GPR17(8), GPR173(4), GPR174(18), GPR27(5), GPR35(8), GPR37(17), GPR4(7), GPR50(21), GPR6(8), GPR63(10), GPR83(12), GPR85(16), GPR87(4), GRPR(7), HCRTR1(4), HCRTR2(24), HRH1(5), HRH2(17), HRH3(7), HTR1A(24), HTR1B(7), HTR1D(5), HTR1E(23), HTR1F(10), HTR2A(6), HTR2B(5), HTR2C(8), HTR4(6), HTR5A(21), HTR6(10), HTR7(11), LHCGR(14), LTB4R(5), MAS1(5), MC1R(2), MC3R(16), MC4R(3), MC5R(22), MLNR(2), MTNR1A(15), MTNR1B(13), NMBR(8), NMUR1(9), NMUR2(23), NPY1R(17), NPY2R(20), NPY5R(22), NTSR1(10), NTSR2(6), OPN1SW(8), OPN3(3), OPRD1(2), OPRK1(12), OPRL1(14), OPRM1(12), OR10A5(14), OR11A1(8), OR12D3(4), OR1C1(29), OR1F1(3), OR1Q1(11), OR2H1(16), OR5V1(6), OR7A5(6), OR7C1(5), OR8B8(12), OXTR(4), P2RY1(4), P2RY10(23), P2RY11(2), P2RY12(2), P2RY13(1), P2RY14(2), P2RY2(3), P2RY6(2), PTAFR(5), PTGDR(8), PTGER2(4), PTGER4(7), PTGFR(12), PTGIR(6), RGR(4), RHO(7), RRH(2), SSTR1(9), SSTR2(4), SSTR3(8), SSTR4(15), SUCNR1(1), TBXA2R(1), TRHR(14)	97389921	1426	387	1406	501	220	598	312	142	150	4	0.0130	1.000	1.000
160	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	75	ACP1(4), ACTB(10), ACTG1(6), ACTN1(7), ACTN2(43), ACTN4(6), ACVR1B(11), ACVR1C(11), BAIAP2(3), CDC42(1), CDH1(6), CREBBP(30), CSNK2A1(5), CSNK2A2(2), CTNNA1(9), CTNNA2(65), CTNNA3(22), CTNNB1(20), CTNND1(10), EGFR(86), EP300(11), ERBB2(12), FARP2(7), FER(16), FGFR1(4), FYN(8), IGF1R(8), INSR(10), IQGAP1(8), LEF1(12), LMO7(22), MAP3K7(10), MAPK1(2), MAPK3(3), MET(22), MLLT4(12), NLK(3), PARD3(15), PTPN1(3), PTPN6(6), PTPRB(50), PTPRF(15), PTPRJ(12), PTPRM(14), PVRL1(16), PVRL3(7), PVRL4(9), RAC2(2), RHOA(4), SMAD2(7), SMAD3(6), SMAD4(21), SNAI1(3), SNAI2(14), SORBS1(12), SRC(2), SSX2IP(3), TCF7(3), TCF7L1(6), TCF7L2(7), TGFBR1(7), TGFBR2(7), TJP1(15), VCL(8), WAS(8), WASF1(10), WASF2(3), WASF3(13), WASL(7), YES1(3)	96545997	845	379	776	207	110	282	162	103	188	0	0.00278	1.000	1.000
161	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	82	ACVR1(7), ACVR1B(11), ACVRL1(11), AKT1(3), AURKB(2), BMPR1A(4), BMPR2(10), BUB1(10), CDIPT(1), CDKL1(1), CDKL2(2), CDS1(3), CDS2(4), CLK1(3), CLK2(10), CLK4(4), COL4A3BP(2), CSNK2A1(5), CSNK2A2(2), DGKA(7), DGKB(40), DGKD(10), DGKE(5), DGKG(15), DGKH(14), DGKQ(1), DGKZ(5), IMPA1(1), INPP1(8), INPP4A(7), INPP4B(27), INPP5A(3), INPPL1(11), ITPKA(2), ITPKB(7), MAP3K10(4), MOS(9), NEK1(11), NEK3(4), OCRL(13), PAK4(6), PIK3C2A(12), PIK3C2B(22), PIK3C2G(19), PIK3CA(30), PIK3CB(8), PIK3CG(33), PIM2(7), PLCB1(52), PLCB2(12), PLCB3(9), PLCB4(35), PLCD1(4), PLCG1(7), PLCG2(18), PLK3(4), PRKACA(3), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PRKCA(10), PRKCD(7), PRKCE(5), PRKCG(20), PRKCH(6), PRKCQ(12), PRKCZ(4), PRKD1(31), PRKG1(20), RAF1(6), RPS6KA1(6), RPS6KA2(8), RPS6KA3(6), RPS6KA4(4), RPS6KB1(3), STK11(87), TGFBR1(7), VRK1(6)	90226248	852	373	817	208	108	313	166	81	180	4	0.00346	1.000	1.000
162	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADA(3), ADCY1(26), ADCY2(51), ADCY3(7), ADCY4(12), ADCY5(27), ADCY6(10), ADCY7(13), ADCY8(48), ADCY9(12), ADK(2), ADSL(2), ADSS(6), ADSSL1(4), AK2(4), AK5(14), AK7(13), ALLC(7), AMPD1(20), AMPD2(7), AMPD3(3), APRT(1), ATIC(7), CANT1(3), DCK(2), DGUOK(4), ENPP1(14), ENPP3(19), ENTPD1(7), ENTPD2(2), ENTPD4(4), ENTPD5(1), ENTPD6(6), ENTPD8(1), FHIT(2), GART(9), GDA(11), GMPR(5), GMPR2(1), GMPS(9), GUCY1A2(28), GUCY1A3(16), GUCY1B3(10), GUCY2C(11), GUCY2D(5), GUCY2F(28), GUK1(2), HPRT1(1), IMPDH1(7), ITPA(1), NME6(3), NME7(4), NPR1(16), NPR2(6), NT5C1A(12), NT5C1B(11), NT5C2(3), NT5E(5), NT5M(3), NUDT2(3), NUDT5(2), NUDT9(2), PAICS(1), PAPSS1(5), PAPSS2(10), PDE10A(31), PDE11A(24), PDE1A(17), PDE1C(28), PDE2A(11), PDE3B(16), PDE4A(7), PDE4B(14), PDE4C(4), PDE4D(5), PDE5A(8), PDE6G(3), PDE7A(3), PDE7B(6), PDE8A(3), PDE8B(10), PDE9A(7), PFAS(9), PKLR(16), PNPT1(12), POLA1(19), POLA2(7), POLD1(7), POLD2(3), POLD3(2), POLD4(2), POLE(31), POLE2(1), POLE4(1), POLR1A(13), POLR1B(11), POLR1D(2), POLR2A(11), POLR2B(10), POLR2C(4), POLR2D(3), POLR2E(2), POLR2F(1), POLR2G(1), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(2), POLR3A(17), POLR3B(20), POLR3G(2), POLR3H(1), POLR3K(2), PPAT(1), PRIM1(3), PRIM2(14), PRPS1(3), PRPS1L1(3), PRPS2(4), PRUNE(5), RFC5(3), RRM1(6), RRM2(6), RRM2B(3), XDH(18), ZNRD1(1)	130985627	1077	372	1071	346	121	407	250	112	184	3	0.531	1.000	1.000
163	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	62	AKT1(3), AKT2(7), AKT3(7), BCL10(4), BLNK(2), BTK(25), CARD11(34), CD19(5), CD22(16), CD72(2), CD79A(2), CD79B(2), CD81(1), CHUK(7), CR2(20), FCGR2B(7), FOS(3), GSK3B(4), HRAS(2), IFITM1(2), IKBKB(9), INPP5D(11), JUN(3), KRAS(169), LILRB3(7), LYN(6), MALT1(13), NFAT5(13), NFATC1(9), NFATC2(15), NFATC3(15), NFATC4(11), NFKB1(6), NFKB2(5), NFKBIA(4), NFKBIB(3), NFKBIE(2), NRAS(4), PIK3CA(30), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PLCG2(18), PPP3CA(14), PPP3CB(3), PPP3CC(3), PPP3R1(5), PTPN6(6), RAC2(2), RASGRP3(11), SYK(5), VAV1(8), VAV2(8), VAV3(32)	59550819	683	372	506	156	62	345	144	44	87	1	1.73e-05	1.000	1.000
164	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	150	AKT1(3), AKT2(7), AKT3(7), BCL2L1(3), CBL(10), CBLB(10), CBLC(1), CCND1(3), CCND2(4), CCND3(1), CISH(1), CNTF(6), CNTFR(5), CREBBP(30), CRLF2(9), CSF2RA(8), CSF2RB(14), CSF3R(6), EP300(11), EPO(6), EPOR(2), GH1(7), GH2(7), GHR(19), GRB2(6), IFNA1(2), IFNA10(7), IFNA14(4), IFNA16(8), IFNA17(5), IFNA2(5), IFNA21(3), IFNA4(4), IFNA5(5), IFNA6(7), IFNA7(6), IFNA8(7), IFNAR1(4), IFNAR2(7), IFNB1(7), IFNG(7), IFNGR1(7), IFNGR2(4), IFNK(1), IFNW1(2), IL10(2), IL10RA(6), IL10RB(6), IL11RA(1), IL12A(2), IL12B(3), IL12RB1(5), IL12RB2(15), IL13(2), IL13RA1(3), IL13RA2(13), IL15(6), IL15RA(2), IL19(2), IL2(7), IL20(2), IL20RA(5), IL21(2), IL21R(14), IL22(4), IL22RA1(7), IL22RA2(6), IL23R(6), IL24(3), IL26(3), IL2RA(6), IL2RB(7), IL2RG(5), IL3(4), IL3RA(8), IL4(1), IL4R(10), IL5(2), IL5RA(9), IL6(2), IL6R(8), IL6ST(3), IL7(2), IL7R(21), IL9(1), IL9R(16), IRF9(3), JAK1(11), JAK2(16), JAK3(10), LEP(4), LEPR(26), LIF(3), LIFR(14), MPL(5), MYC(4), OSM(5), OSMR(7), PIAS1(2), PIAS2(6), PIAS3(7), PIAS4(2), PIK3CA(30), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PIM1(1), PRL(3), PRLR(18), PTPN11(9), PTPN6(6), SOCS2(3), SOCS4(1), SOCS5(8), SOCS7(2), SOS1(17), SOS2(13), SPRED1(5), SPRED2(4), SPRY1(3), SPRY2(5), SPRY3(9), SPRY4(4), STAM(11), STAM2(5), STAT1(7), STAT2(6), STAT3(11), STAT4(11), STAT5A(3), STAT5B(8), STAT6(2), TPO(33), TSLP(8), TYK2(5)	116625933	974	368	958	303	91	392	216	105	169	1	0.716	1.000	1.000
165	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(9), ACTA2(1), ACTN2(43), ACTN4(6), DES(4), DMD(108), MYBPC1(21), MYBPC2(8), MYBPC3(15), MYH3(37), MYH6(42), MYH7(59), MYH8(73), MYL1(4), MYL2(8), MYL3(4), MYL4(2), MYL9(3), MYOM1(16), NEB(91), TCAP(1), TMOD1(5), TNNC2(2), TNNI1(3), TNNI2(4), TNNI3(6), TNNT1(3), TNNT2(6), TNNT3(5), TPM1(1), TPM2(3), TPM3(2), TPM4(2), TTN(654), VIM(5)	110040676	1256	368	1243	364	127	537	301	128	150	13	0.571	1.000	1.000
166	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	74	AKT1(3), AKT2(7), AKT3(7), BTK(25), FCER1A(9), FCER1G(2), FYN(8), GAB2(7), GRB2(6), HRAS(2), IL13(2), IL3(4), IL4(1), IL5(2), INPP5D(11), KRAS(169), LAT(4), LCP2(10), LYN(6), MAP2K1(10), MAP2K2(1), MAP2K3(13), MAP2K4(8), MAP2K6(5), MAP2K7(7), MAPK1(2), MAPK10(6), MAPK12(2), MAPK13(1), MAPK14(4), MAPK3(3), MAPK8(2), MAPK9(8), MS4A2(7), NRAS(4), PDK1(6), PIK3CA(30), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PLA2G12A(4), PLA2G12B(3), PLA2G1B(2), PLA2G2A(5), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(6), PLA2G4A(21), PLA2G6(3), PLCG1(7), PLCG2(18), PRKCA(10), PRKCD(7), PRKCE(5), RAC2(2), RAF1(6), SOS1(17), SOS2(13), SYK(5), TNF(2), VAV1(8), VAV2(8), VAV3(32)	57520397	672	356	495	147	61	335	145	40	89	2	4.23e-06	1.000	1.000
167	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	110	ACTN1(7), ACTN2(43), ACTN4(6), ARHGAP5(17), BCAR1(3), CD99(3), CDC42(1), CDH5(13), CLDN1(1), CLDN10(7), CLDN11(4), CLDN14(6), CLDN15(1), CLDN16(8), CLDN17(10), CLDN18(5), CLDN2(5), CLDN20(2), CLDN22(1), CLDN4(3), CLDN6(2), CLDN8(6), CLDN9(2), CTNNA1(9), CTNNA2(65), CTNNA3(22), CTNNB1(20), CTNND1(10), CXCL12(3), CXCR4(6), CYBA(1), CYBB(11), ESAM(2), EZR(3), F11R(3), GNAI1(10), GNAI3(2), ICAM1(2), ITGA4(38), ITGAL(26), ITGAM(24), ITGB1(6), ITGB2(8), ITK(16), JAM2(9), JAM3(4), MAPK12(2), MAPK13(1), MAPK14(4), MLLT4(12), MMP2(24), MMP9(10), MSN(8), MYL2(8), MYL5(2), MYL7(4), MYL9(3), NCF1(3), NCF2(8), NCF4(3), NOX1(8), NOX3(21), OCLN(1), PIK3CA(30), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PLCG1(7), PLCG2(18), PRKCA(10), PRKCG(20), PTK2(6), PTK2B(14), PTPN11(9), PXN(1), RAC2(2), RAP1A(1), RAP1B(2), RAPGEF3(7), RAPGEF4(13), RHOA(4), RHOH(6), ROCK1(19), ROCK2(9), SIPA1(2), THY1(6), TXK(7), VASP(2), VAV1(8), VAV2(8), VAV3(32), VCAM1(28), VCL(8)	99432479	935	355	912	277	113	406	197	78	139	2	0.0790	1.000	1.000
168	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	69	AKT1(3), AKT2(7), AKT3(7), CASP9(6), CDC42(1), HRAS(2), KDR(56), KRAS(169), MAP2K1(10), MAP2K2(1), MAPK1(2), MAPK12(2), MAPK13(1), MAPK14(4), MAPK3(3), MAPKAPK2(2), MAPKAPK3(3), NFAT5(13), NFATC1(9), NFATC2(15), NFATC3(15), NFATC4(11), NOS3(12), NRAS(4), PIK3CA(30), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PLA2G12A(4), PLA2G12B(3), PLA2G1B(2), PLA2G2A(5), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(6), PLA2G4A(21), PLA2G6(3), PLCG1(7), PLCG2(18), PPP3CA(14), PPP3CB(3), PPP3CC(3), PPP3R1(5), PRKCA(10), PRKCG(20), PTGS2(12), PTK2(6), PXN(1), RAC2(2), RAF1(6), SH2D2A(10), SHC2(5), SPHK2(4), SRC(2), VEGFA(1)	57134632	645	352	464	158	62	339	132	53	58	1	0.000122	1.000	1.000
169	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	78	ABL1(9), ACTN1(7), ACTR2(4), ACTR3(2), AKT1(3), AKT2(7), AKT3(7), ANGPTL2(5), ARHGEF6(21), ARHGEF7(6), BCAR1(3), BRAF(44), CAV1(1), CDC42(1), CDKN2A(22), CRK(1), CSE1L(7), DOCK1(15), EPHB2(10), FYN(8), GRB2(6), GRB7(8), ILK(1), ITGA1(14), ITGA10(16), ITGA11(12), ITGA2(25), ITGA3(8), ITGA4(38), ITGA5(11), ITGA6(12), ITGA7(13), ITGA8(59), ITGA9(6), MAP2K4(8), MAP2K7(7), MAP3K11(5), MAPK1(2), MAPK10(6), MAPK8(2), MAPK8IP1(4), MAPK8IP2(2), MAPK8IP3(7), MAPK9(8), MRAS(1), MYLK(26), MYLK2(9), P4HB(5), PAK1(9), PAK2(3), PAK3(16), PAK4(6), PAK6(2), PAK7(37), PIK3CA(30), PIK3CB(8), PKLR(16), PLCG1(7), PLCG2(18), PTEN(11), PTK2(6), RAF1(6), RALA(5), RHO(7), ROCK1(19), ROCK2(9), SHC1(6), SOS1(17), SOS2(13), SRC(2), TLN1(15), TLN2(30), VASP(2), WAS(8), ZYX(6)	97934119	818	351	767	230	99	317	171	66	163	2	0.0833	1.000	1.000
170	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(21), AMY2A(6), AMY2B(11), ASCC3(23), ATP13A2(11), DDX18(9), DDX23(5), DDX4(10), DDX41(3), DDX47(1), DDX50(12), DDX52(4), DDX54(7), DDX55(3), DDX56(3), DHX58(4), ENPP1(14), ENPP3(19), ENTPD7(6), EP400(32), ERCC2(5), ERCC3(5), G6PC(7), G6PC2(8), GAA(12), GANC(3), GBA(7), GBE1(8), GCK(6), GPI(8), GUSB(5), GYS1(4), GYS2(8), HK1(12), HK2(11), HK3(22), IFIH1(10), LYZL1(5), MGAM(51), MOV10L1(11), NUDT5(2), NUDT8(2), PGM1(3), PGM3(3), PYGB(5), PYGL(6), PYGM(9), RAD54B(8), RAD54L(7), RUVBL2(4), SETX(27), SI(117), SKIV2L2(15), SMARCA2(22), SMARCA5(5), TREH(1), UGDH(6), UGP2(4), UGT1A1(12), UGT1A10(9), UGT1A3(6), UGT1A4(4), UGT1A5(8), UGT1A6(9), UGT1A7(7), UGT1A9(7), UGT2A1(16), UGT2A3(11), UGT2B10(9), UGT2B11(23), UGT2B15(14), UGT2B17(12), UGT2B28(23), UGT2B4(28), UGT2B7(14), UXS1(6)	99524772	876	344	869	238	93	371	192	83	137	0	0.0583	1.000	1.000
171	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	108	A4GNT(6), ALG1(2), ALG10(15), ALG10B(8), ALG11(7), ALG12(3), ALG13(15), ALG14(1), ALG2(3), ALG3(4), ALG6(1), ALG8(3), ALG9(5), B3GNT1(3), B3GNT2(4), B3GNT6(5), B3GNT7(5), B4GALT1(1), B4GALT2(4), B4GALT3(2), B4GALT4(2), B4GALT5(6), C1GALT1(5), C1GALT1C1(4), CHPF(10), CHST1(17), CHST11(2), CHST12(6), CHST13(3), CHST14(2), CHST2(14), CHST3(1), CHST4(3), CHST6(7), CHST7(2), CHSY1(5), DAD1(2), DDOST(1), DPAGT1(5), EXT1(8), EXT2(11), EXTL1(8), EXTL2(3), EXTL3(13), FUT11(5), FUT8(7), GALNT1(6), GALNT10(6), GALNT11(3), GALNT12(3), GALNT13(35), GALNT14(24), GALNT2(11), GALNT3(12), GALNT4(4), GALNT5(10), GALNT6(5), GALNT7(9), GALNT8(19), GALNTL5(5), GANAB(9), GCNT1(8), GCNT3(2), GCNT4(9), HS2ST1(1), HS3ST1(8), HS3ST2(7), HS3ST3A1(7), HS3ST5(18), HS6ST1(5), HS6ST2(3), HS6ST3(12), MAN1A1(3), MAN1A2(7), MAN1B1(4), MAN1C1(3), MAN2A1(20), MGAT1(7), MGAT2(5), MGAT3(15), MGAT4A(3), MGAT4B(7), MGAT5(13), MGAT5B(22), NDST1(6), NDST2(6), NDST3(16), NDST4(36), OGT(19), RPN1(3), RPN2(4), ST3GAL1(4), ST3GAL2(4), ST3GAL3(4), ST3GAL4(4), ST6GAL1(4), ST6GALNAC1(8), STT3B(4), UST(5), WBSCR17(33), XYLT1(44), XYLT2(3)	88486212	806	341	797	271	127	297	187	85	108	2	0.672	1.000	1.000
172	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(17), ABCA10(34), ABCA12(39), ABCA13(86), ABCA2(21), ABCA3(11), ABCA4(19), ABCA5(23), ABCA6(26), ABCA7(18), ABCA8(25), ABCA9(26), ABCB1(45), ABCB10(11), ABCB11(28), ABCB4(19), ABCB5(60), ABCB6(4), ABCB7(12), ABCB8(11), ABCB9(7), ABCC1(14), ABCC10(11), ABCC11(38), ABCC12(22), ABCC2(11), ABCC3(13), ABCC4(21), ABCC5(14), ABCC6(9), ABCC8(25), ABCC9(30), ABCD1(2), ABCD2(14), ABCD3(2), ABCD4(5), ABCG1(8), ABCG2(14), ABCG4(16), ABCG5(19), ABCG8(19), CFTR(11), TAP1(1), TAP2(8)	94274026	869	341	863	263	85	335	202	88	155	4	0.109	1.000	1.000
173	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	109	ADA(3), ADCY1(26), ADCY2(51), ADCY3(7), ADCY4(12), ADCY5(27), ADCY6(10), ADCY7(13), ADCY8(48), ADK(2), ADSL(2), ADSS(6), AK2(4), AK5(14), ALLC(7), AMPD1(20), AMPD2(7), AMPD3(3), APRT(1), ATIC(7), ATP1B1(6), ATP5A1(4), ATP5B(3), ATP5C1(4), ATP5F1(3), ATP5G3(2), ATP5J2(3), CANT1(3), DCK(2), DGUOK(4), ENPP1(14), ENPP3(19), ENTPD1(7), ENTPD2(2), FHIT(2), GART(9), GDA(11), GMPS(9), GUCY1A2(28), GUCY1A3(16), GUCY1B3(10), GUCY2C(11), GUCY2D(5), GUCY2F(28), GUK1(2), HPRT1(1), IMPDH1(7), ITPA(1), NPR1(16), NPR2(6), NT5E(5), NT5M(3), NUDT2(3), PAICS(1), PAPSS1(5), PAPSS2(10), PDE1A(17), PDE4A(7), PDE4B(14), PDE4C(4), PDE4D(5), PDE5A(8), PDE6B(15), PDE6C(12), PDE6G(3), PDE7B(6), PDE8A(3), PDE9A(7), PFAS(9), PKLR(16), POLB(4), POLD1(7), POLD2(3), POLE(31), POLG(12), POLL(7), POLQ(36), POLR1B(11), POLR2A(11), POLR2B(10), POLR2C(4), POLR2D(3), POLR2E(2), POLR2F(1), POLR2G(1), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(2), POLRMT(8), PPAT(1), PRPS1(3), PRPS1L1(3), PRPS2(4), PRUNE(5), RRM1(6), RRM2(6)	102556225	846	333	841	281	101	313	191	90	149	2	0.678	1.000	1.000
174	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	73	CALM1(3), CALM2(1), CALML3(3), CALML6(1), CDIPT(1), CDS1(3), CDS2(4), DGKA(7), DGKB(40), DGKD(10), DGKE(5), DGKG(15), DGKH(14), DGKI(35), DGKQ(1), DGKZ(5), FN3K(1), IMPA1(1), IMPA2(1), INPP1(8), INPP4A(7), INPP4B(27), INPP5A(3), INPP5B(10), INPP5D(11), INPP5E(2), INPPL1(11), ITPK1(1), ITPKA(2), ITPKB(7), ITPR1(20), ITPR2(40), ITPR3(21), OCRL(13), PI4KA(17), PI4KB(10), PIK3C2A(12), PIK3C2B(22), PIK3C2G(19), PIK3C3(14), PIK3CA(30), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PIP4K2A(7), PIP4K2B(3), PIP4K2C(7), PIP5K1A(6), PIP5K1B(6), PIP5K1C(4), PLCB1(52), PLCB2(12), PLCB3(9), PLCB4(35), PLCD1(4), PLCD3(2), PLCD4(7), PLCE1(28), PLCG1(7), PLCG2(18), PLCZ1(8), PRKCA(10), PRKCG(20), PTEN(11), PTPMT1(1), SYNJ1(14), SYNJ2(9)	99499360	816	332	800	230	102	309	184	72	145	4	0.0651	1.000	1.000
175	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(3), AKT3(7), BCAR1(3), CAPN1(2), CAPN10(8), CAPN11(13), CAPN2(5), CAPN3(8), CAPN5(12), CAPN6(25), CAPN7(7), CAPN9(5), CAPNS1(1), CAV1(1), CAV2(1), CAV3(3), CDC42(1), CRK(1), CSK(2), DOCK1(15), FYN(8), GIT2(5), GRB2(6), ILK(1), ITGA10(16), ITGA11(12), ITGA2(25), ITGA2B(12), ITGA3(8), ITGA4(38), ITGA5(11), ITGA6(12), ITGA7(13), ITGA8(59), ITGA9(6), ITGAD(38), ITGAE(20), ITGAL(26), ITGAM(24), ITGAV(14), ITGAX(52), ITGB1(6), ITGB2(8), ITGB3(13), ITGB4(10), ITGB5(4), ITGB6(11), ITGB7(2), ITGB8(15), MAP2K1(10), MAP2K2(1), MAP2K3(13), MAP2K6(5), MAPK10(6), MAPK12(2), MAPK4(9), MAPK6(4), MAPK7(7), MYLK2(9), PAK1(9), PAK2(3), PAK3(16), PAK4(6), PAK6(2), PDPK1(3), PIK3R2(7), PTK2(6), PXN(1), RAC2(2), RAP1B(2), RAPGEF1(7), RHO(7), ROCK1(19), ROCK2(9), SDCCAG8(12), SEPP1(1), SHC1(6), SHC3(8), SORBS1(12), SOS1(17), SRC(2), TLN1(15), TNS1(23), VASP(2), VAV2(8), VAV3(32), VCL(8), ZYX(6)	107108167	915	332	904	268	88	386	192	75	170	4	0.108	1.000	1.000
176	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	66	A2M(24), BDKRB1(1), BDKRB2(3), C1QA(7), C1QB(11), C1QC(5), C1R(4), C1S(4), C2(10), C3(13), C3AR1(11), C4BPA(6), C4BPB(1), C5(6), C5AR1(7), C6(29), C7(39), C8A(18), C8B(20), C9(20), CD46(3), CD55(3), CFB(4), CFH(46), CFI(6), CPB2(6), CR1(34), CR2(20), F10(5), F11(13), F12(4), F13A1(29), F13B(28), F2(9), F2R(10), F3(3), F5(40), F7(10), F8(56), F9(20), FGA(20), FGB(18), FGG(4), KLKB1(6), KNG1(9), MASP1(13), MASP2(8), MBL2(13), PLAT(12), PLAUR(4), PLG(32), PROC(4), PROS1(30), SERPINA1(4), SERPINA5(18), SERPINC1(5), SERPIND1(3), SERPINE1(14), SERPINF2(2), SERPING1(7), TFPI(4), THBD(4), VWF(32)	72761103	854	331	843	243	73	400	155	75	149	2	0.157	1.000	1.000
177	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	82	ANPEP(10), CD14(1), CD19(5), CD1A(23), CD1B(17), CD1C(15), CD1D(10), CD1E(27), CD2(6), CD22(16), CD33(13), CD34(13), CD36(4), CD37(2), CD38(4), CD3D(2), CD3E(2), CD4(8), CD44(7), CD5(7), CD55(3), CD8A(4), CD8B(5), CD9(3), CR1(34), CR2(20), CSF1(1), CSF1R(18), CSF2RA(8), CSF3R(6), DNTT(6), EPO(6), EPOR(2), FCER2(2), FCGR1A(5), FLT3(24), FLT3LG(2), GP5(8), HLA-DRA(3), HLA-DRB1(5), IL11RA(1), IL1A(4), IL1B(1), IL1R1(2), IL1R2(5), IL2RA(6), IL3(4), IL3RA(8), IL4(1), IL4R(10), IL5(2), IL5RA(9), IL6(2), IL6R(8), IL7(2), IL7R(21), IL9R(16), ITGA1(14), ITGA2(25), ITGA2B(12), ITGA3(8), ITGA4(38), ITGA5(11), ITGA6(12), ITGAM(24), ITGB3(13), KIT(12), KITLG(6), MME(20), MS4A1(11), TFRC(6), THPO(7), TNF(2), TPO(33)	65727396	713	312	700	232	68	297	133	69	146	0	0.703	1.000	1.000
178	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	69	ACACB(28), ACSL1(12), ACSL3(4), ACSL4(7), ACSL5(3), ACSL6(15), ADIPOQ(6), ADIPOR1(6), ADIPOR2(3), AKT1(3), AKT2(7), AKT3(7), CAMKK1(4), CAMKK2(3), CD36(4), CHUK(7), CPT1A(11), CPT1B(6), CPT1C(13), CPT2(3), G6PC(7), G6PC2(8), IKBKB(9), IRS1(20), IRS4(34), JAK1(11), JAK2(16), JAK3(10), LEP(4), LEPR(26), MAPK10(6), MAPK8(2), MAPK9(8), NFKB1(6), NFKB2(5), NFKBIA(4), NFKBIB(3), NFKBIE(2), NPY(4), PCK1(21), PCK2(4), POMC(4), PPARA(4), PPARGC1A(23), PRKAA1(6), PRKAA2(8), PRKAB1(3), PRKAG1(1), PRKAG2(5), PRKAG3(8), PRKCQ(12), PTPN11(9), RELA(3), RXRA(1), RXRB(3), RXRG(18), SLC2A1(1), SLC2A4(4), STAT3(11), STK11(87), TNF(2), TNFRSF1B(2), TRADD(2), TRAF2(5), TYK2(5)	65718655	589	311	568	181	66	202	106	62	153	0	0.474	1.000	1.000
179	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	98	AKT1(3), AKT2(7), AKT3(7), CASP8(6), CCL4(2), CD14(1), CD40(3), CD80(3), CD86(11), CHUK(7), CXCL10(1), CXCL11(1), CXCL9(4), FADD(2), FOS(3), IFNA1(2), IFNA10(7), IFNA14(4), IFNA16(8), IFNA17(5), IFNA2(5), IFNA21(3), IFNA4(4), IFNA5(5), IFNA6(7), IFNA7(6), IFNA8(7), IFNAR1(4), IFNAR2(7), IFNB1(7), IKBKB(9), IKBKE(9), IL12A(2), IL12B(3), IL1B(1), IL6(2), IRAK1(6), IRAK4(4), IRF5(1), IRF7(3), JUN(3), LBP(8), LY96(3), MAP2K1(10), MAP2K2(1), MAP2K3(13), MAP2K4(8), MAP2K6(5), MAP2K7(7), MAP3K7(10), MAP3K8(4), MAPK1(2), MAPK10(6), MAPK12(2), MAPK13(1), MAPK14(4), MAPK3(3), MAPK8(2), MAPK9(8), MYD88(1), NFKB1(6), NFKB2(5), NFKBIA(4), PIK3CA(30), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), RELA(3), RIPK1(11), SPP1(5), STAT1(7), TBK1(4), TICAM1(3), TLR1(9), TLR2(10), TLR3(4), TLR4(64), TLR5(8), TLR6(11), TLR7(17), TLR8(16), TLR9(9), TNF(2), TOLLIP(2), TRAF3(4), TRAF6(6)	71758645	601	307	587	191	54	241	133	73	100	0	0.572	1.000	1.000
180	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	88	ACVR1(7), ACVR1B(11), ACVR1C(11), ACVR2A(5), ACVR2B(4), ACVRL1(11), AMHR2(6), BMP2(1), BMP4(6), BMP5(6), BMP6(8), BMP7(12), BMP8A(2), BMPR1A(4), BMPR1B(7), BMPR2(10), CHRD(13), COMP(4), CREBBP(30), CUL1(14), DCN(5), E2F4(5), E2F5(1), EP300(11), FST(5), GDF5(12), GDF6(10), GDF7(5), ID1(1), ID2(4), ID3(3), IFNG(7), INHBA(31), INHBB(4), INHBC(4), INHBE(5), LEFTY1(7), LEFTY2(4), LTBP1(61), MAPK1(2), MAPK3(3), MYC(4), NODAL(2), NOG(1), PITX2(8), PPP2CA(1), PPP2CB(3), PPP2R1A(10), PPP2R1B(5), PPP2R2A(8), PPP2R2B(12), PPP2R2C(5), RBL1(7), RBL2(5), RHOA(4), ROCK1(19), ROCK2(9), RPS6KB1(3), RPS6KB2(3), SKP1(4), SMAD1(7), SMAD2(7), SMAD3(6), SMAD4(21), SMAD5(1), SMAD6(2), SMAD9(4), SMURF1(8), SMURF2(4), SP1(6), TFDP1(10), TGFB1(3), TGFB2(10), TGFBR1(7), TGFBR2(7), THBS1(8), THBS2(35), THBS3(5), THBS4(8), TNF(2), ZFYVE16(7), ZFYVE9(14)	79353108	657	304	652	180	106	234	140	65	111	1	0.0539	1.000	1.000
181	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT1(3), AKT2(7), AKT3(7), ASAH1(3), BRAF(44), DAG1(3), DRD2(26), EGFR(86), EPHB2(10), GRB2(6), ITPKA(2), ITPKB(7), ITPR1(20), ITPR2(40), ITPR3(21), KCNJ3(36), KCNJ5(10), KCNJ9(2), MAPK1(2), PI3(1), PIK3CB(8), PITX2(8), PLCB1(52), PLCB2(12), PLCB3(9), PLCB4(35), RAF1(6), RGS20(8), SHC1(6), SOS1(17), SOS2(13), SRC(2), STAT3(11)	46979625	523	302	443	116	51	187	113	64	106	2	0.00251	1.000	1.000
182	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	91	ACTB(10), BCL2(5), CABIN1(10), CALM1(3), CALM2(1), CAMK2B(16), CAMK4(16), CD3E(2), CD69(2), CDKN1A(2), CNR1(15), CREBBP(30), CSNK2A1(5), CTLA4(3), EGR2(4), EGR3(1), EP300(11), FCER1A(9), FCGR3A(9), FOS(3), FOSL1(4), GATA3(12), GATA4(7), GSK3A(1), GSK3B(4), HRAS(2), ICOS(5), IFNA1(2), IFNB1(7), IFNG(7), IL10(2), IL13(2), IL1B(1), IL2(7), IL2RA(6), IL3(4), IL4(1), IL6(2), ITK(16), JUNB(1), KPNA5(4), MAP2K7(7), MAPK14(4), MAPK8(2), MAPK9(8), MEF2A(2), MEF2B(2), MEF2D(4), MYF5(12), NCK2(6), NFAT5(13), NFATC1(9), NFATC2(15), NFATC3(15), NFATC4(11), NFKB2(5), NFKBIB(3), NFKBIE(2), NPPB(3), NUP214(26), OPRD1(2), P2RX7(6), PAK1(9), PIN1(1), PPP3CB(3), PPP3CC(3), PPP3R1(5), PTPRC(41), RELA(3), RPL13A(2), SFN(1), SLA(6), SP1(6), SP3(6), TGFB1(3), TNF(2), TRAF2(5), TRPV6(25), VAV1(8), VAV2(8), VAV3(32), XPO5(6)	72801598	586	297	581	183	67	223	121	48	125	2	0.434	1.000	1.000
183	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	52	ADORA3(4), ALG6(1), CCKBR(24), CCR2(6), CCR3(4), CCR5(4), CELSR1(17), CELSR2(22), CELSR3(36), CHRM2(39), CHRM3(27), CIDEB(2), CXCR3(3), DRD4(2), EDNRA(3), EMR2(13), EMR3(10), F2R(10), FSHR(37), GHRHR(5), GNRHR(5), GPR116(11), GPR132(6), GPR133(18), GPR135(4), GPR143(2), GPR17(8), GPR18(4), GPR55(9), GPR56(6), GPR61(8), GPR84(4), GRM1(48), GRPR(7), HRH4(5), LGR6(22), LPHN2(47), LPHN3(78), NTSR1(10), OR2M4(33), P2RY11(2), P2RY13(1), PTGFR(12), SMO(17), SSTR2(4), TAAR5(11), TSHR(22), VN1R1(2)	52700176	675	297	669	208	99	272	140	67	95	2	0.0223	1.000	1.000
184	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	62	AKT1(3), AKT2(7), AKT3(7), BCL2L1(3), CDC42(1), CDK2(1), CDKN1B(5), CDKN2A(22), CREB1(2), CREB5(18), EBP(3), ERBB4(51), F2RL2(12), GAB1(7), GADD45A(2), GRB2(6), GSK3A(1), GSK3B(4), IFI27(1), IGF1(4), IGFBP1(6), INPPL1(11), IRS1(20), IRS4(34), MET(22), MYC(4), NOLC1(5), PAK1(9), PAK2(3), PAK3(16), PAK4(6), PAK6(2), PAK7(37), PARD3(15), PARD6A(1), PDK1(6), PIK3CA(30), PIK3CD(4), PPP1R13B(7), PREX1(40), PTEN(11), PTK2(6), PTPN1(3), RPS6KA1(6), RPS6KA2(8), RPS6KA3(6), RPS6KB1(3), SFN(1), SHC1(6), SLC2A4(4), SOS1(17), SOS2(13), TSC1(10), TSC2(13), YWHAB(1), YWHAE(1), YWHAG(3), YWHAH(1), YWHAQ(4), YWHAZ(2)	61212291	557	294	533	133	72	231	108	39	107	0	0.00204	1.000	1.000
185	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(9), AKT1(3), BDKRB2(3), CALM1(3), CALM2(1), CAV1(1), CHRM1(5), CHRNA1(16), FLT1(31), FLT4(20), KDR(56), NOS3(12), PDE2A(11), PDE3A(30), PDE3B(16), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PRKG1(20), PRKG2(15), RYR2(359), SLC7A1(5), SYT1(6), TNNI1(3)	32393146	649	288	629	183	62	297	127	63	91	9	0.0364	1.000	1.000
186	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(33), ASH2L(2), CARM1(4), CTCFL(21), DOT1L(14), EED(8), EHMT1(15), EHMT2(9), EZH1(4), EZH2(11), FBXO11(5), HCFC1(24), HSF4(1), JMJD4(3), JMJD6(3), KDM6A(12), MEN1(6), NSD1(23), OGT(19), PAXIP1(7), PPP1CA(2), PPP1CB(4), PPP1CC(1), PRDM2(21), PRDM7(6), PRDM9(82), PRMT5(7), PRMT6(7), PRMT7(4), PRMT8(13), RBBP5(3), SATB1(10), SETD1A(18), SETD2(39), SETD7(2), SETD8(1), SETDB1(11), SETDB2(13), SETMAR(5), SMYD3(10), STK38(3), SUV39H1(1), SUV39H2(4), SUV420H1(16), WHSC1(12), WHSC1L1(8)	95093196	527	278	521	148	56	203	125	45	92	6	0.453	1.000	1.000
187	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	44	AKT1(3), AKT2(7), AKT3(7), BRAF(44), CAB39(2), DDIT4(4), EIF4B(7), FIGF(4), HIF1A(2), IGF1(4), MAPK1(2), MAPK3(3), PDPK1(3), PGF(1), PIK3CA(30), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PRKAA1(6), PRKAA2(8), RHEB(4), RICTOR(25), RPS6(3), RPS6KA1(6), RPS6KA2(8), RPS6KA3(6), RPS6KA6(18), RPS6KB1(3), RPS6KB2(3), STK11(87), TSC1(10), TSC2(13), ULK1(8), ULK2(9), ULK3(2), VEGFA(1), VEGFB(2), VEGFC(21)	41941776	444	278	390	88	44	166	86	39	107	2	0.000285	1.000	1.000
188	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	84	ATF2(10), BRAF(44), CHUK(7), CREB1(2), DAXX(8), ELK1(3), FOS(3), GRB2(6), HRAS(2), IKBKB(9), JUN(3), MAP2K1(10), MAP2K2(1), MAP2K3(13), MAP2K4(8), MAP2K5(4), MAP2K6(5), MAP2K7(7), MAP3K1(7), MAP3K10(4), MAP3K11(5), MAP3K12(10), MAP3K13(12), MAP3K2(6), MAP3K3(10), MAP3K4(21), MAP3K5(14), MAP3K6(4), MAP3K7(10), MAP3K8(4), MAP3K9(17), MAP4K1(12), MAP4K2(4), MAP4K3(12), MAP4K4(8), MAP4K5(2), MAPK1(2), MAPK10(6), MAPK12(2), MAPK13(1), MAPK14(4), MAPK3(3), MAPK4(9), MAPK6(4), MAPK7(7), MAPK8(2), MAPK9(8), MAPKAPK2(2), MAPKAPK3(3), MAPKAPK5(5), MAX(8), MEF2A(2), MEF2B(2), MEF2C(6), MEF2D(4), MKNK1(4), MKNK2(2), MYC(4), NFKB1(6), NFKBIA(4), PAK1(9), PAK2(3), RAF1(6), RELA(3), RIPK1(11), RPS6KA1(6), RPS6KA2(8), RPS6KA3(6), RPS6KA4(4), RPS6KA5(10), RPS6KB1(3), RPS6KB2(3), SHC1(6), SP1(6), STAT1(7), TGFB1(3), TGFB2(10), TGFBR1(7), TRADD(2), TRAF2(5)	75906247	525	276	496	137	57	188	109	45	125	1	0.0711	1.000	1.000
189	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	47	FN3K(1), IMPA1(1), IMPA2(1), INPP1(8), INPP4A(7), INPP4B(27), INPP5A(3), INPP5B(10), INPP5E(2), INPPL1(11), IPMK(11), ISYNA1(1), ITPK1(1), ITPKA(2), ITPKB(7), MINPP1(3), MIOX(2), OCRL(13), PI4KA(17), PI4KB(10), PIK3C3(14), PIK3CA(30), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIP4K2A(7), PIP4K2B(3), PIP4K2C(7), PIP5K1A(6), PIP5K1B(6), PIP5K1C(4), PLCB1(52), PLCB2(12), PLCB3(9), PLCB4(35), PLCD1(4), PLCD3(2), PLCD4(7), PLCE1(28), PLCG1(7), PLCG2(18), PLCZ1(8), PTEN(11), PTPMT1(1), SYNJ1(14), SYNJ2(9)	59264272	477	269	463	136	55	186	114	41	79	2	0.139	1.000	1.000
190	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	34	AKT1(3), APC(33), AR(10), ASAH1(3), BRAF(44), CAMP(4), CCL13(3), CCL15(5), CCL16(4), DAG1(3), EGFR(86), GNA11(4), GNA15(1), GNAI1(10), GNAQ(5), ITPKA(2), ITPKB(7), ITPR1(20), ITPR2(40), ITPR3(21), KCNJ3(36), KCNJ5(10), KCNJ9(2), MAPK1(2), MAPK10(6), MAPK14(4), PHKA2(14), PIK3CA(30), PIK3CD(4), PIK3R1(4), PITX2(8), PTX3(3), RAF1(6), SRC(2)	42843438	439	268	351	81	39	150	97	49	103	1	0.000151	1.000	1.000
191	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	65	ADAM10(9), ADAM17(8), ATP6AP1(3), ATP6V0A1(6), ATP6V0A2(4), ATP6V0A4(8), ATP6V0B(2), ATP6V0C(4), ATP6V0D1(2), ATP6V0D2(8), ATP6V1A(6), ATP6V1B1(3), ATP6V1B2(5), ATP6V1C1(7), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1E2(5), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3), CASP3(5), CDC42(1), CHUK(7), CSK(2), CXCL1(1), EGFR(86), F11R(3), GIT1(3), IGSF5(6), IKBKB(9), JAM2(9), JAM3(4), JUN(3), LYN(6), MAP2K4(8), MAPK10(6), MAPK12(2), MAPK13(1), MAPK14(4), MAPK8(2), MAPK9(8), MET(22), NFKB1(6), NFKB2(5), NFKBIA(4), NOD1(7), PAK1(9), PLCG1(7), PLCG2(18), PTPN11(9), PTPRZ1(72), RELA(3), SRC(2), TCIRG1(2), TJP1(15)	56419102	450	267	394	127	44	136	78	66	125	1	0.439	1.000	1.000
192	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR1(9), AGTR2(6), ATP8A1(7), AVPR1A(14), AVPR1B(7), AVPR2(7), BDKRB1(1), BDKRB2(3), BRS3(8), C3AR1(11), CCKAR(14), CCKBR(24), CCR1(3), CCR10(1), CCR2(6), CCR3(4), CCR4(3), CCR5(4), CCR6(9), CCR8(6), CX3CR1(11), CXCR3(3), CXCR4(6), CXCR6(2), EDNRA(3), EDNRB(16), FPR1(10), FSHR(37), GALR1(8), GALR2(3), GALR3(1), GALT(5), GHSR(5), GNB2L1(3), GNRHR(5), GRPR(7), LHCGR(14), MC1R(2), MC2R(12), MC3R(16), MC4R(3), MC5R(22), NMBR(8), NPY1R(17), NPY2R(20), NPY5R(22), NTSR1(10), NTSR2(6), OPRD1(2), OPRK1(12), OPRL1(14), OPRM1(12), OXTR(4), SSTR1(9), SSTR2(4), SSTR3(8), SSTR4(15), TAC4(1), TACR1(4), TACR2(2), TACR3(15), TRHR(14), TSHR(22)	42039386	562	266	554	217	89	233	122	53	64	1	0.475	1.000	1.000
193	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	ACTR2(4), ACTR3(2), AKT1(3), AKT2(7), AKT3(7), ANGPTL2(5), ARHGAP1(5), ARHGAP4(14), ARHGEF11(24), BTK(25), CDC42(1), CFL2(3), GDI1(6), GDI2(1), INPPL1(11), ITPR1(20), ITPR2(40), ITPR3(21), LIMK1(3), MYLK(26), MYLK2(9), PAK1(9), PAK2(3), PAK3(16), PAK4(6), PAK6(2), PAK7(37), PDK1(6), PIK3CA(30), PIK3CD(4), PIK3CG(33), PIK3R1(4), PITX2(8), PPP1R13B(7), PTEN(11), RACGAP1(7), RHO(7), ROCK1(19), ROCK2(9), RPS4X(2), SAG(5), WASF1(10), WASL(7)	56336808	479	261	462	127	71	181	96	37	94	0	0.0271	1.000	1.000
194	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	AKT1(3), AKT2(7), AKT3(7), BCL2(5), BCR(11), BLNK(2), BTK(25), CD19(5), CD22(16), CD81(1), CR2(20), CSK(2), DAG1(3), FLOT1(1), FLOT2(4), GRB2(6), GSK3A(1), GSK3B(4), INPP5D(11), ITPR1(20), ITPR2(40), ITPR3(21), LYN(6), MAP4K1(12), MAPK1(2), MAPK3(3), NFATC1(9), NFATC2(15), NR0B2(3), PDK1(6), PIK3CA(30), PIK3CD(4), PIK3R1(4), PLCG2(18), PPP1R13B(7), PPP3CA(14), PPP3CB(3), PPP3CC(3), PTPRC(41), RAF1(6), SHC1(6), SOS1(17), SOS2(13), SYK(5), VAV1(8)	59335258	450	259	431	140	55	166	107	34	88	0	0.416	1.000	1.000
195	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CD2BP2(5), CDC40(4), CLK2(10), CLK3(2), CLK4(4), COL2A1(24), CPSF1(14), CPSF2(8), CPSF3(6), CSTF1(7), CSTF2(3), CSTF2T(7), CSTF3(7), DDIT3(2), DDX1(9), DDX20(4), DHX15(7), DHX16(7), DHX38(9), DHX8(14), DHX9(12), DICER1(15), DNAJC8(4), FUS(5), GIPC1(6), LSM2(1), LSM7(2), METTL3(3), NCBP1(3), NCBP2(3), NONO(6), NXF1(11), PABPN1(5), PAPOLA(11), POLR2A(11), PPM1G(6), PRPF18(3), PRPF3(5), PRPF4(3), PRPF4B(11), PRPF8(10), PSKH1(3), PTBP1(4), PTBP2(9), RBM17(4), RBM5(6), RNGTT(10), RNMT(8), RNPS1(1), SF3A1(10), SF3A2(1), SF3A3(2), SF3B1(15), SF3B2(14), SF3B4(8), SF3B5(3), SNRPA(1), SNRPA1(1), SNRPB(3), SNRPB2(1), SNRPD1(2), SNRPD3(4), SNRPE(1), SNRPG(2), SNRPN(15), SNURF(2), SPOP(4), SRPK1(5), SRPK2(6), SRRM1(4), SUPT5H(9), U2AF1(12), U2AF2(6), XRN2(8)	85058513	473	258	457	127	70	162	100	53	88	0	0.231	1.000	1.000
196	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(21), AMY2A(6), AMY2B(11), ENPP1(14), ENPP3(19), G6PC(7), GAA(12), GANAB(9), GBE1(8), GCK(6), GPI(8), GUSB(5), GYS1(4), GYS2(8), HK1(12), HK2(11), HK3(22), MGAM(51), PGM1(3), PGM3(3), PYGB(5), PYGL(6), PYGM(9), RNPC3(1), SI(117), UCHL1(4), UCHL3(1), UGDH(6), UGT1A1(12), UGT1A10(9), UGT1A3(6), UGT1A4(4), UGT1A5(8), UGT1A6(9), UGT1A7(7), UGT1A9(7), UGT2B15(14), UGT2B4(28), UXS1(6)	45835022	499	251	495	132	58	224	102	42	73	0	0.0372	1.000	1.000
197	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ADCY4(12), ADCY6(10), ADCY8(48), CACNA1A(32), CACNA1B(39), GNAS(29), GNAT3(6), GNB1(2), GNB3(5), GNG13(5), GNG3(1), GRM4(21), ITPR3(21), KCNB1(28), PDE1A(17), PLCB2(12), PRKACA(3), PRKACB(9), PRKACG(4), PRKX(3), SCNN1A(2), SCNN1B(6), SCNN1G(8), TAS1R1(5), TAS1R2(28), TAS1R3(6), TAS2R1(20), TAS2R10(2), TAS2R13(2), TAS2R14(4), TAS2R16(15), TAS2R3(2), TAS2R38(9), TAS2R39(5), TAS2R4(3), TAS2R40(7), TAS2R41(15), TAS2R42(2), TAS2R43(1), TAS2R46(5), TAS2R5(3), TAS2R50(1), TAS2R60(9), TAS2R7(3), TAS2R9(3), TRPM5(11)	45162780	484	250	476	163	86	193	118	30	57	0	0.143	1.000	1.000
198	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	51	ACTA1(9), AGT(4), AKT1(3), CALM1(3), CALM2(1), CALR(2), CAMK1(1), CAMK1G(2), CAMK4(16), CREBBP(30), CSNK1A1(2), EDN1(1), ELSPBP1(8), F2(9), GATA4(7), GSK3B(4), HAND1(5), HAND2(10), HRAS(2), IGF1(4), LIF(3), MAP2K1(10), MAPK1(2), MAPK14(4), MAPK3(3), MAPK8(2), MEF2C(6), MYH2(77), NFATC1(9), NFATC2(15), NFATC3(15), NFATC4(11), NKX2-5(8), NPPA(3), PIK3CA(30), PIK3R1(4), PPP3CA(14), PPP3CB(3), PPP3CC(3), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), RAF1(6), RPS6KB1(3), SYT1(6)	40746036	384	250	366	98	57	160	81	28	57	1	0.0185	1.000	1.000
199	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(4), AKR1D1(12), ARSD(6), ARSE(5), CARM1(4), CYP11B1(27), CYP11B2(24), CYP19A1(4), HSD11B1(9), HSD17B1(2), HSD17B12(4), HSD17B2(6), HSD17B3(3), HSD17B7(3), HSD3B1(6), HSD3B2(15), LCMT1(5), LCMT2(7), METTL2B(5), METTL6(1), PRMT2(2), PRMT3(8), PRMT5(7), PRMT6(7), PRMT7(4), PRMT8(13), SRD5A1(4), STS(9), SULT1E1(11), SULT2A1(6), SULT2B1(2), UGT1A1(12), UGT1A10(9), UGT1A3(6), UGT1A4(4), UGT1A5(8), UGT1A6(9), UGT1A7(7), UGT1A9(7), UGT2A1(16), UGT2A3(11), UGT2B10(9), UGT2B11(23), UGT2B15(14), UGT2B17(12), UGT2B28(23), UGT2B4(28), UGT2B7(14), WBSCR22(3)	40649497	440	248	434	125	40	196	106	41	56	1	0.122	1.000	1.000
200	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	AICDA(3), CAD(25), CANT1(3), CDA(2), CTPS2(6), DCK(2), DCTD(4), DHODH(1), DPYD(24), DPYS(22), ENTPD1(7), ENTPD4(4), ENTPD5(1), ENTPD6(6), ENTPD8(1), ITPA(1), NME6(3), NME7(4), NT5C1A(12), NT5C1B(11), NT5C2(3), NT5E(5), NT5M(3), NUDT2(3), PNPT1(12), POLA1(19), POLA2(7), POLD1(7), POLD2(3), POLD3(2), POLD4(2), POLE(31), POLE2(1), POLE4(1), POLR1A(13), POLR1B(11), POLR1D(2), POLR2A(11), POLR2B(10), POLR2C(4), POLR2D(3), POLR2E(2), POLR2F(1), POLR2G(1), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(2), POLR3A(17), POLR3B(20), POLR3G(2), POLR3H(1), POLR3K(2), PRIM1(3), PRIM2(14), RFC5(3), RRM1(6), RRM2(6), RRM2B(3), TK1(1), TK2(1), TXNRD1(7), TXNRD2(2), TYMS(3), UCK2(10), UMPS(4), UPB1(2), UPP1(6), UPP2(6), UPRT(5), ZNRD1(1)	64981879	430	247	429	121	51	169	101	38	68	3	0.191	1.000	1.000
201	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP2(1), BMP4(6), BMP5(6), BMP6(8), BMP7(12), BMP8A(2), BTRC(12), CSNK1A1(2), CSNK1A1L(14), CSNK1D(7), CSNK1E(6), CSNK1G1(4), CSNK1G2(2), CSNK1G3(8), DHH(2), FBXW11(2), GLI1(17), GLI2(28), GLI3(39), GSK3B(4), HHIP(4), IHH(3), LRP2(88), PRKACA(3), PRKACB(9), PRKACG(4), PRKX(3), PTCH1(16), PTCH2(8), RAB23(1), SHH(2), SMO(17), STK36(12), SUFU(2), WNT1(6), WNT10A(10), WNT10B(10), WNT11(6), WNT16(9), WNT2(7), WNT2B(4), WNT3A(10), WNT4(1), WNT5A(2), WNT5B(6), WNT7A(14), WNT7B(4), WNT8A(9), WNT8B(8), WNT9A(6), WNT9B(6), ZIC2(3)	48461340	475	245	468	135	96	190	101	33	55	0	0.0389	1.000	1.000
202	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(8), ADH1B(12), ADH4(4), ADH5(2), ADH6(8), ADH7(11), ADHFE1(5), AGK(6), AGPAT1(9), AGPAT2(3), AGPAT3(4), AGPAT4(9), AGPAT6(5), AKR1A1(1), AKR1B1(7), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH7A1(3), ALDH9A1(3), CEL(8), DAK(4), DGAT1(1), DGKA(7), DGKB(40), DGKD(10), DGKE(5), DGKG(15), DGKH(14), DGKI(35), DGKQ(1), DGKZ(5), GK(7), GK2(10), GLA(9), GLB1(3), GPAM(6), LCT(50), LIPA(2), LIPC(9), LIPF(8), LIPG(11), LPL(8), MGLL(2), PNLIP(19), PNLIPRP1(14), PNPLA3(4), PPAP2A(2), PPAP2B(3), PPAP2C(1)	46900800	443	237	435	120	52	181	95	37	77	1	0.0378	1.000	1.000
203	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	69	ADH1A(8), ADH1B(12), ADH4(4), ADH5(2), ADH6(8), ADH7(11), ADHFE1(5), AKR1C1(4), AKR1C2(2), AKR1C3(5), AKR1C4(4), ALDH1A3(4), ALDH3A1(5), ALDH3B1(2), ALDH3B2(4), CYP1A1(9), CYP1A2(3), CYP1B1(5), CYP2B6(10), CYP2C18(7), CYP2C19(13), CYP2C8(2), CYP2C9(8), CYP2E1(7), CYP2F1(3), CYP2S1(3), CYP3A4(4), CYP3A43(3), CYP3A5(5), CYP3A7(7), DHDH(3), EPHX1(7), GSTA1(7), GSTA2(7), GSTA3(2), GSTA4(2), GSTA5(6), GSTK1(1), GSTM1(1), GSTM2(4), GSTM3(2), GSTM4(1), GSTM5(3), GSTO2(3), GSTP1(2), GSTT1(1), GSTZ1(2), MGST1(1), MGST2(2), MGST3(2), UGT1A1(12), UGT1A10(9), UGT1A3(6), UGT1A4(4), UGT1A5(8), UGT1A6(9), UGT1A7(7), UGT1A9(7), UGT2A1(16), UGT2A3(11), UGT2B10(9), UGT2B11(23), UGT2B15(14), UGT2B17(12), UGT2B28(23), UGT2B4(28), UGT2B7(14)	46469574	440	237	435	124	37	200	95	35	73	0	0.108	1.000	1.000
204	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	33	AKT1(3), AKT2(7), AKT3(7), BCR(11), BTK(25), CD19(5), CDKN2A(22), DAPP1(3), FLOT1(1), FLOT2(4), GAB1(7), ITPR1(20), ITPR2(40), ITPR3(21), LYN(6), NR0B2(3), PDK1(6), PIK3CA(30), PITX2(8), PLCG2(18), PPP1R13B(7), PREX1(40), PTEN(11), PTPRC(41), RPS6KA1(6), RPS6KA2(8), RPS6KA3(6), RPS6KB1(3), SAG(5), SYK(5), TEC(12), VAV1(8)	44383020	399	236	383	91	49	152	89	26	83	0	0.00211	1.000	1.000
205	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACADL(4), ACADM(8), ACOX1(5), ACOX2(3), ACOX3(8), ACSL1(12), ACSL3(4), ACSL4(7), ACSL5(3), ACSL6(15), ADIPOQ(6), ANGPTL4(2), APOA1(3), APOA2(1), APOA5(10), APOC3(2), AQP7(7), CD36(4), CPT1A(11), CPT1B(6), CPT1C(13), CPT2(3), CYP27A1(5), CYP4A11(8), CYP4A22(1), CYP7A1(8), CYP8B1(4), EHHADH(13), FABP2(1), FABP3(4), FABP4(2), FABP5(1), FABP6(3), FABP7(2), FADS2(4), GK(7), GK2(10), HMGCS2(7), ILK(1), LPL(8), ME1(3), MMP1(11), NR1H3(4), OLR1(8), PCK1(21), PCK2(4), PDPK1(3), PLTP(7), PPARA(4), PPARD(6), PPARG(8), RXRA(1), RXRB(3), RXRG(18), SCD(3), SCP2(4), SLC27A1(4), SLC27A2(4), SLC27A4(4), SLC27A5(7), SLC27A6(24), SORBS1(12), UBC(14), UCP1(3)	52667188	406	234	404	122	51	159	79	50	67	0	0.292	1.000	1.000
206	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(9), ACTB(10), ACTG1(6), ARHGEF2(8), ARPC5(1), CD14(1), CDC42(1), CDH1(6), CLDN1(1), CTNNB1(20), CTTN(6), EZR(3), FYN(8), HCLS1(17), ITGB1(6), LY96(3), NCK1(5), NCK2(6), NCL(10), OCLN(1), PRKCA(10), RHOA(4), ROCK1(19), ROCK2(9), TLR4(64), TLR5(8), TUBA1A(4), TUBA1B(3), TUBA1C(4), TUBA3C(28), TUBA3D(13), TUBA3E(9), TUBA4A(3), TUBA8(1), TUBAL3(3), TUBB(2), TUBB1(6), TUBB2A(3), TUBB2B(4), TUBB3(3), TUBB6(3), TUBB8(17), WAS(8), WASL(7), YWHAQ(4), YWHAZ(2)	42267861	369	234	359	106	42	154	70	42	61	0	0.144	1.000	1.000
207	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(9), ACTB(10), ACTG1(6), ARHGEF2(8), ARPC5(1), CD14(1), CDC42(1), CDH1(6), CLDN1(1), CTNNB1(20), CTTN(6), EZR(3), FYN(8), HCLS1(17), ITGB1(6), LY96(3), NCK1(5), NCK2(6), NCL(10), OCLN(1), PRKCA(10), RHOA(4), ROCK1(19), ROCK2(9), TLR4(64), TLR5(8), TUBA1A(4), TUBA1B(3), TUBA1C(4), TUBA3C(28), TUBA3D(13), TUBA3E(9), TUBA4A(3), TUBA8(1), TUBAL3(3), TUBB(2), TUBB1(6), TUBB2A(3), TUBB2B(4), TUBB3(3), TUBB6(3), TUBB8(17), WAS(8), WASL(7), YWHAQ(4), YWHAZ(2)	42267861	369	234	359	106	42	154	70	42	61	0	0.144	1.000	1.000
208	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(36), COL4A2(40), COL4A3(16), COL4A4(22), COL4A5(50), COL4A6(28), F10(5), F11(13), F12(4), F2(9), F2R(10), F5(40), F8(56), F9(20), FGA(20), FGB(18), FGG(4), KLKB1(6), PROC(4), PROS1(30), SERPINC1(5), SERPING1(7)	35804097	443	234	440	122	32	230	77	32	71	1	0.437	1.000	1.000
209	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG1(6), ACTG2(10), ACTR2(4), ACTR3(2), AKT1(3), ANGPTL2(5), CDC42(1), CFL2(3), FLNA(31), FLNC(55), FSCN1(4), FSCN2(1), FSCN3(14), GDI1(6), GDI2(1), LIMK1(3), MYH2(77), MYLK(26), MYLK2(9), PAK1(9), PAK2(3), PAK3(16), PAK4(6), PAK6(2), PAK7(37), PFN1(1), PFN2(1), RHO(7), ROCK1(19), ROCK2(9), RPS4X(2), VASP(2), WASF1(10), WASL(7)	38011947	392	233	384	132	55	161	69	41	66	0	0.450	1.000	1.000
210	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	42	BCL2(5), CHUK(7), DAXX(8), EGF(13), EGFR(86), ETS1(8), ETS2(6), FOS(3), HOXA7(6), HRAS(2), IKBKB(9), JUN(3), MAP2K1(10), MAP2K3(13), MAP2K4(8), MAP2K6(5), MAP2K7(7), MAP3K1(7), MAP3K5(14), MAPK1(2), MAPK13(1), MAPK14(4), MAPK3(3), MAPK8(2), NFKB1(6), NFKBIA(4), PPP2CA(1), PRKCA(10), PRKCD(7), PRKCE(5), PRKCG(20), PRKCH(6), PRKCQ(12), RAF1(6), RELA(3), RIPK1(11), SP1(6), TNF(2), TNFRSF1B(2), TRAF2(5)	39438567	338	229	286	94	32	98	61	57	88	2	0.460	1.000	1.000
211	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(33), AXIN1(7), CCND1(3), CCND2(4), CCND3(1), CSNK1E(6), CTNNB1(20), DVL1(5), DVL2(7), DVL3(13), FBXW2(4), FOSL1(4), FZD1(6), FZD10(26), FZD2(8), FZD3(2), FZD5(5), FZD6(3), FZD7(7), FZD8(6), FZD9(4), GSK3B(4), JUN(3), LDLR(9), MAPK10(6), MAPK9(8), MYC(4), PAFAH1B1(1), PPP2R5C(1), PPP2R5E(5), PRKCA(10), PRKCD(7), PRKCE(5), PRKCG(20), PRKCH(6), PRKCI(11), PRKCQ(12), PRKCZ(4), PRKD1(31), RHOA(4), SFRP4(7), TCF7(3), WNT1(6), WNT10A(10), WNT10B(10), WNT11(6), WNT16(9), WNT2(7), WNT2B(4), WNT4(1), WNT5A(2), WNT5B(6), WNT7A(14), WNT7B(4)	47839156	414	229	402	108	87	152	73	30	70	2	0.00959	1.000	1.000
212	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	ADAM17(8), APH1A(3), CREBBP(30), CTBP1(2), DLL1(5), DLL3(6), DLL4(2), DTX1(10), DTX2(6), DTX3(6), DTX3L(3), DTX4(2), DVL1(5), DVL2(7), DVL3(13), EP300(11), HDAC1(4), HDAC2(8), HES1(2), JAG1(16), JAG2(7), LFNG(3), MAML1(9), MAML2(10), MAML3(9), MFNG(1), NCOR2(30), NCSTN(13), NOTCH1(26), NOTCH2(26), NOTCH3(11), NOTCH4(53), NUMB(3), NUMBL(3), PSEN1(6), PSEN2(9), PSENEN(2), PTCRA(8), RBPJ(3), RBPJL(5), RFNG(1), SNW1(3)	54216501	390	224	389	114	63	143	81	38	64	1	0.147	1.000	1.000
213	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	50	ACOX1(5), APOA1(3), APOA2(1), CD36(4), CITED2(3), CPT1B(6), CREBBP(30), DUSP1(1), EHHADH(13), EP300(11), HSD17B4(8), JUN(3), LPL(8), MAPK1(2), MAPK3(3), ME1(3), MRPL11(1), MYC(4), NCOA1(18), NCOR1(23), NCOR2(30), NFKBIA(4), NR0B2(3), NR1H3(4), NR2F1(7), NRIP1(13), PDGFA(5), PIK3CA(30), PIK3R1(4), PPARA(4), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PRKCA(10), PTGS2(12), RB1(33), RELA(3), RXRA(1), SP1(6), STAT5A(3), STAT5B(8), TNF(2)	50606647	356	223	342	94	48	122	70	34	81	1	0.108	1.000	1.000
214	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(5), ACSS2(4), ACYP2(1), ADH1A(8), ADH1B(12), ADH4(4), ADH5(2), ADH6(8), ADH7(11), ADHFE1(5), AKR1A1(1), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH3B1(2), ALDH3B2(4), ALDH7A1(3), ALDH9A1(3), ALDOA(4), ALDOB(8), ALDOC(2), BPGM(6), DLAT(10), DLD(9), ENO1(7), ENO2(2), ENO3(3), FBP1(2), FBP2(2), G6PC(7), G6PC2(8), GALM(2), GAPDH(5), GAPDHS(10), GCK(6), GPI(8), HK1(12), HK2(11), HK3(22), LDHA(10), LDHAL6A(1), LDHAL6B(3), LDHB(4), LDHC(6), PDHA1(5), PDHA2(29), PFKL(9), PFKM(7), PFKP(5), PGAM1(1), PGAM2(1), PGAM4(6), PGK1(4), PGK2(27), PGM1(3), PGM3(3), PKLR(16), TPI1(9)	46692040	398	221	393	118	58	163	74	37	66	0	0.133	1.000	1.000
215	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	ACTG1(6), APAF1(10), ARHGDIB(2), BCL2(5), BID(2), BIRC2(2), BIRC3(4), CASP2(13), CASP3(5), CASP6(3), CASP7(3), CASP8(6), CASP9(6), CFLAR(2), CHUK(7), CRADD(3), CYCS(2), DAXX(8), DFFA(3), DFFB(4), FADD(2), GSN(4), LMNA(2), LMNB1(5), LMNB2(5), MAP2K7(7), MAP3K1(7), MAP3K5(14), MAPK8(2), MDM2(5), NFKB1(6), NFKBIA(4), NUMA1(16), PAK2(3), PRKCD(7), PRKDC(50), PSEN1(6), PSEN2(9), PTK2(6), RASA1(11), RB1(33), RELA(3), RIPK1(11), SPTAN1(21), TNF(2), TNFRSF1B(2), TRADD(2), TRAF1(2), TRAF2(5)	55298179	348	218	346	92	27	102	76	41	102	0	0.372	1.000	1.000
216	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	IMPA1(1), INPP1(8), INPP4A(7), INPP4B(27), INPP5A(3), INPPL1(11), ITPKA(2), ITPKB(7), MIOX(2), OCRL(13), PIK3C2A(12), PIK3C2B(22), PIK3C2G(19), PIK3CA(30), PIK3CB(8), PIK3CG(33), PLCB1(52), PLCB2(12), PLCB3(9), PLCB4(35), PLCD1(4), PLCG1(7), PLCG2(18)	35920520	342	217	329	87	44	136	75	30	56	1	0.0435	1.000	1.000
217	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	35	ACTA1(9), CRK(1), CRKL(4), DOCK1(15), ELK1(3), FOS(3), GAB1(7), GRB2(6), HGF(54), HRAS(2), ITGA1(14), ITGB1(6), JUN(3), MAP2K1(10), MAP2K2(1), MAP4K1(12), MAPK1(2), MAPK3(3), MAPK8(2), MET(22), PAK1(9), PIK3CA(30), PIK3R1(4), PTEN(11), PTK2(6), PTK2B(14), PTPN11(9), PXN(1), RAF1(6), RAP1A(1), RAP1B(2), RASA1(11), SOS1(17), SRC(2), STAT3(11)	35495397	313	217	292	93	23	115	67	43	65	0	0.700	1.000	1.000
218	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	ADRB1(1), AKT1(3), APC(33), ASAH1(3), CAMP(4), CAV3(3), DAG1(3), DLG4(7), EPHB2(10), GNAI1(10), GNAQ(5), ITPR1(20), ITPR2(40), ITPR3(21), KCNJ3(36), KCNJ5(10), KCNJ9(2), MAPK1(2), PITX2(8), PTX3(3), RHO(7), RYR1(111)	36904482	342	217	337	96	60	118	80	25	57	2	0.0827	1.000	1.000
219	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(10), CD28(4), CD3D(2), CSK(2), CTLA4(3), DAG1(3), EPHB2(10), FBXW7(15), GRAP2(13), GRB2(6), ITK(16), ITPKA(2), ITPKB(7), LAT(4), LCK(9), LCP2(10), MAPK1(2), NCK1(5), NFAT5(13), NFKB1(6), NFKB2(5), NFKBIA(4), NFKBIB(3), NFKBIE(2), NFKBIL1(1), PAK1(9), PAK2(3), PAK3(16), PAK4(6), PAK6(2), PAK7(37), PLCG1(7), PTPRC(41), RAF1(6), RASGRP1(3), RASGRP2(7), RASGRP3(11), RASGRP4(9), SOS1(17), SOS2(13), VAV1(8), ZAP70(9)	44571429	361	215	351	113	50	141	66	25	79	0	0.493	1.000	1.000
220	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(134), B3GALT4(1), CDR1(15), DGKI(35), IL6ST(3), MRPL19(1), PIGK(3), RPL10(4), RPL11(2), RPL13A(2), RPL14(2), RPL15(1), RPL17(2), RPL19(2), RPL21(1), RPL22(1), RPL24(1), RPL26(3), RPL27A(2), RPL28(2), RPL29(1), RPL3(3), RPL30(2), RPL31(1), RPL34(1), RPL37(2), RPL3L(8), RPL4(5), RPL41(1), RPL5(8), RPL6(4), RPL7(2), RPL8(3), RPL9(1), RPLP0(2), RPLP1(1), RPLP2(3), RPS10(3), RPS11(1), RPS13(1), RPS14(1), RPS15(2), RPS16(4), RPS18(2), RPS19(1), RPS2(2), RPS20(1), RPS25(2), RPS26(1), RPS27(1), RPS28(1), RPS29(1), RPS3(5), RPS3A(2), RPS4X(2), RPS4Y1(1), RPS5(2), RPS6(3), RPS6KA1(6), RPS6KA2(8), RPS6KA3(6), RPS6KA6(18), RPS6KB1(3), RPS6KB2(3), RPS7(1), RPSA(1), SLC36A2(6), UBA52(1), UBC(14)	41821993	371	214	364	103	38	175	73	27	56	2	0.164	1.000	1.000
221	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(8), ADH1B(12), ADH4(4), ADH6(8), ADH7(11), ADHFE1(5), AGPAT1(9), AGPAT2(3), AGPAT3(4), AGPAT4(9), AKR1A1(1), AKR1B1(7), ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH9A1(3), CEL(8), DGAT1(1), DGKA(7), DGKB(40), DGKD(10), DGKE(5), DGKG(15), DGKH(14), DGKQ(1), DGKZ(5), GK(7), GLA(9), GLB1(3), LCT(50), LIPC(9), LIPF(8), LIPG(11), LPL(8), PNLIP(19), PNLIPRP1(14), PPAP2A(2), PPAP2B(3), PPAP2C(1)	38463524	380	213	374	91	47	155	78	31	69	0	0.00291	1.000	1.000
222	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(5), F11(13), F12(4), F13B(28), F2(9), F5(40), F7(10), F8(56), F9(20), FGA(20), FGB(18), FGG(4), LPA(47), PLAT(12), PLG(32), SERPINB2(14), SERPINE1(14), SERPINF2(2), VWF(32)	28374054	380	210	374	103	24	171	80	38	66	1	0.179	1.000	1.000
223	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AADAT(3), AANAT(1), ACAT1(2), ACAT2(2), ACMSD(2), AFMID(4), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH7A1(3), ALDH9A1(3), AOC2(6), AOC3(11), AOX1(22), ASMT(13), CARM1(4), CAT(3), CYP1A1(9), CYP1A2(3), CYP1B1(5), DDC(8), ECHS1(4), EHHADH(13), GCDH(7), HAAO(1), HADH(2), HADHA(3), HSD17B10(2), HSD17B4(8), INMT(8), KMO(9), KYNU(17), LCMT1(5), LCMT2(7), LNX1(9), MAOA(5), MAOB(3), METTL2B(5), METTL6(1), NFX1(5), OGDH(10), OGDHL(35), PRMT2(2), PRMT3(8), PRMT5(7), PRMT6(7), PRMT7(4), PRMT8(13), TDO2(9), TPH1(8), TPH2(16), WARS(6), WARS2(7), WBSCR22(3)	48745420	383	210	376	110	53	128	82	50	70	0	0.160	1.000	1.000
224	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	48	AKT1(3), AKT2(7), AKT3(7), BRD4(7), CBL(10), CDC42(1), CDKN2A(22), F2RL2(12), FLOT1(1), FLOT2(4), GRB2(6), GSK3A(1), GSK3B(4), IGFBP1(6), INPPL1(11), IRS1(20), IRS4(34), LNPEP(5), MAPK1(2), MAPK3(3), PARD3(15), PARD6A(1), PDK1(6), PIK3CA(30), PIK3CD(4), PIK3R1(4), PTEN(11), PTPN1(3), RAF1(6), RPS6KA1(6), RPS6KA2(8), RPS6KA3(6), RPS6KB1(3), SERPINB6(3), SFN(1), SHC1(6), SLC2A4(4), SORBS1(12), SOS1(17), SOS2(13), YWHAB(1), YWHAE(1), YWHAG(3), YWHAH(1), YWHAQ(4), YWHAZ(2)	47146229	337	210	318	83	41	138	80	23	54	1	0.0397	1.000	1.000
225	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(3), AASDHPPT(4), AASS(20), ACAT1(2), ACAT2(2), AKR1B10(10), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH7A1(3), ALDH9A1(3), BBOX1(11), DLST(5), DOT1L(14), ECHS1(4), EHHADH(13), EHMT1(15), EHMT2(9), GCDH(7), HADH(2), HADHA(3), HSD17B10(2), HSD17B4(8), HSD3B7(7), NSD1(23), OGDH(10), OGDHL(35), PIPOX(2), PLOD1(5), PLOD2(12), PLOD3(10), RDH11(4), RDH12(3), RDH13(1), RDH14(2), SETD1A(18), SETD7(2), SETDB1(11), SHMT1(2), SHMT2(2), SPCS1(1), SPCS3(2), SUV39H1(1), SUV39H2(4), TMLHE(9)	46424015	336	209	332	93	50	131	73	33	47	2	0.0900	1.000	1.000
226	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	EGFR(86), ELK1(3), GNAS(29), GNB1(2), GNGT1(6), GRB2(6), HRAS(2), IGF1R(8), ITGB1(6), KLK2(10), MAP2K1(10), MAP2K2(1), MAPK1(2), MAPK3(3), MKNK1(4), MKNK2(2), MYC(4), NGFR(5), PDGFRA(41), PPP2CA(1), PTPRR(16), RAF1(6), RPS6KA1(6), RPS6KA5(10), SHC1(6), SOS1(17), SRC(2), STAT3(11)	26484085	305	208	248	64	35	104	51	52	62	1	0.0160	1.000	1.000
227	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	42	AKT1(3), ASAH1(3), ATF1(1), BRAF(44), CAMP(4), CREB1(2), CREB5(18), CREBBP(30), CRKL(4), DAG1(3), EGR1(6), EGR2(4), EGR3(1), EGR4(3), ELK1(3), FRS2(10), GNAQ(5), JUN(3), MAP1B(29), MAP2K4(8), MAP2K7(7), MAPK1(2), MAPK10(6), MAPK3(3), MAPK8(2), MAPK8IP1(4), MAPK8IP2(2), MAPK8IP3(7), MAPK9(8), NTRK1(14), OPN1LW(9), PIK3C2G(19), PIK3CA(30), PIK3CD(4), PIK3R1(4), PTPN11(9), RPS6KA3(6), SHC1(6), SRC(2), TH(7)	40873459	335	208	299	83	50	137	74	20	52	2	0.00707	1.000	1.000
228	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	63	ACHE(4), AGPAT1(9), AGPAT2(3), AGPAT3(4), AGPAT4(9), AGPAT6(5), CDIPT(1), CDS1(3), CDS2(4), CHAT(22), CHKA(4), CHKB(4), CHPT1(3), DGKA(7), DGKB(40), DGKD(10), DGKE(5), DGKG(15), DGKH(14), DGKI(35), DGKQ(1), DGKZ(5), ESCO1(10), ESCO2(4), ETNK1(5), GNPAT(5), GPAM(6), GPD1(3), GPD1L(4), GPD2(9), LCAT(6), NAT6(1), PCYT1A(2), PCYT1B(3), PEMT(2), PISD(2), PLA2G12A(4), PLA2G12B(3), PLA2G1B(2), PLA2G2A(5), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(6), PLA2G4A(21), PLA2G6(3), PLD1(19), PLD2(7), PNPLA3(4), PPAP2A(2), PPAP2B(3), PPAP2C(1), PTDSS1(10), PTDSS2(3)	52161680	368	207	361	118	42	131	92	34	67	2	0.721	1.000	1.000
229	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(5), EGF(13), EGFR(86), ELK1(3), FOS(3), GRB2(6), HRAS(2), JAK1(11), JUN(3), MAP2K1(10), MAP2K4(8), MAP3K1(7), MAPK3(3), MAPK8(2), PIK3CA(30), PIK3R1(4), PLCG1(7), PRKCA(10), RAF1(6), RASA1(11), SHC1(6), SOS1(17), SRF(1), STAT1(7), STAT3(11), STAT5A(3)	30286601	275	204	211	50	24	75	45	55	76	0	0.0117	1.000	1.000
230	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(17), CALCR(27), CALCRL(18), CD97(12), CRHR1(7), ELTD1(39), EMR1(24), EMR2(13), GHRHR(5), GIPR(3), GLP1R(11), GLP2R(17), GPR64(14), LPHN1(7), LPHN2(47), LPHN3(78), SCTR(5), VIPR1(2), VIPR2(3)	21308194	349	203	346	101	34	140	68	44	62	1	0.131	1.000	1.000
231	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	CALM1(3), CALM2(1), CD3D(2), CD3E(2), ELK1(3), FOS(3), FYN(8), GRB2(6), HRAS(2), JUN(3), LAT(4), LCK(9), MAP2K1(10), MAP2K4(8), MAP3K1(7), MAPK3(3), MAPK8(2), NFATC1(9), NFATC2(15), NFATC3(15), NFATC4(11), NFKB1(6), NFKBIA(4), PIK3CA(30), PIK3R1(4), PLCG1(7), PPP3CA(14), PPP3CB(3), PPP3CC(3), PRKCA(10), PTPN7(1), RAF1(6), RASA1(11), RELA(3), SHC1(6), SOS1(17), SYT1(6), VAV1(8), ZAP70(9)	38495246	274	202	256	78	39	105	49	25	56	0	0.257	1.000	1.000
232	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAD(1), ALAS1(2), ALAS2(6), BLVRA(3), BLVRB(2), COX10(4), CP(11), CPOX(4), EARS2(5), EPRS(27), FECH(4), FTH1(2), FTMT(11), GUSB(5), HCCS(3), HMBS(5), HMOX1(3), MMAB(3), PPOX(7), UGT1A1(12), UGT1A10(9), UGT1A3(6), UGT1A4(4), UGT1A5(8), UGT1A6(9), UGT1A7(7), UGT1A9(7), UGT2A1(16), UGT2A3(11), UGT2B10(9), UGT2B11(23), UGT2B15(14), UGT2B17(12), UGT2B28(23), UGT2B4(28), UGT2B7(14), UROS(2)	34202749	322	201	320	96	21	153	77	25	46	0	0.443	1.000	1.000
233	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1A(7), ADRA1B(8), ADRA1D(8), ADRA2A(3), ADRA2C(3), ADRB1(1), ADRB2(4), ADRB3(6), CHRM1(5), CHRM2(39), CHRM3(27), CHRM4(8), CHRM5(6), DRD1(13), DRD2(26), DRD3(19), DRD4(2), DRD5(26), HRH1(5), HRH2(17), HTR1A(24), HTR1B(7), HTR1D(5), HTR1E(23), HTR1F(10), HTR2A(6), HTR2B(5), HTR2C(8), HTR4(6), HTR5A(21), HTR6(10), HTR7(11)	20500751	369	201	364	126	55	168	70	29	45	2	0.0457	1.000	1.000
234	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(9), ALPL(3), ALPP(13), ALPPL2(4), ASCC3(23), ATP13A2(11), DDX18(9), DDX23(5), DDX4(10), DDX41(3), DDX47(1), DDX50(12), DDX52(4), DDX54(7), DDX55(3), DDX56(3), DHFR(2), DHX58(4), ENTPD7(6), EP400(32), ERCC2(5), ERCC3(5), FPGS(3), GCH1(3), GGH(9), IFIH1(10), MOV10L1(11), NUDT5(2), NUDT8(2), PTS(1), QDPR(7), RAD54B(8), RAD54L(7), RUVBL2(4), SETX(27), SKIV2L2(15), SMARCA2(22), SMARCA5(5), SPR(3)	50269127	313	199	311	95	33	102	82	35	61	0	0.533	1.000	1.000
235	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	BTK(25), CALM1(3), CALM2(1), ELK1(3), FCER1A(9), FCER1G(2), FOS(3), GRB2(6), HRAS(2), JUN(3), LYN(6), MAP2K1(10), MAP2K4(8), MAP2K7(7), MAP3K1(7), MAPK1(2), MAPK3(3), MAPK8(2), NFATC1(9), NFATC2(15), NFATC3(15), NFATC4(11), PAK2(3), PIK3CA(30), PIK3R1(4), PLA2G4A(21), PLCG1(7), PPP3CA(14), PPP3CB(3), PPP3CC(3), RAF1(6), SHC1(6), SOS1(17), SYK(5), SYT1(6), VAV1(8)	34558555	285	198	267	67	33	110	65	23	54	0	0.0285	1.000	1.000
236	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP2(1), ADH1A(8), ADH1B(12), ADH4(4), ADH6(8), ADH7(11), ADHFE1(5), AKR1A1(1), ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH3B1(2), ALDH3B2(4), ALDH9A1(3), ALDOA(4), ALDOB(8), ALDOC(2), BPGM(6), DLAT(10), DLD(9), ENO1(7), ENO2(2), ENO3(3), FBP1(2), FBP2(2), G6PC(7), GAPDH(5), GCK(6), GPI(8), HK1(12), HK2(11), HK3(22), LDHA(10), LDHB(4), LDHC(6), PDHA1(5), PDHA2(29), PFKM(7), PFKP(5), PGAM1(1), PGK1(4), PGM1(3), PGM3(3), PKLR(16), TPI1(9)	39312877	333	197	329	91	48	135	63	30	57	0	0.0416	1.000	1.000
237	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP2(1), ADH1A(8), ADH1B(12), ADH4(4), ADH6(8), ADH7(11), ADHFE1(5), AKR1A1(1), ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH3B1(2), ALDH3B2(4), ALDH9A1(3), ALDOA(4), ALDOB(8), ALDOC(2), BPGM(6), DLAT(10), DLD(9), ENO1(7), ENO2(2), ENO3(3), FBP1(2), FBP2(2), G6PC(7), GAPDH(5), GCK(6), GPI(8), HK1(12), HK2(11), HK3(22), LDHA(10), LDHB(4), LDHC(6), PDHA1(5), PDHA2(29), PFKM(7), PFKP(5), PGAM1(1), PGK1(4), PGM1(3), PGM3(3), PKLR(16), TPI1(9)	39312877	333	197	329	91	48	135	63	30	57	0	0.0416	1.000	1.000
238	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(4), AGTR1(9), ATF2(10), CALM1(3), CALM2(1), EGFR(86), ELK1(3), GNAQ(5), GRB2(6), HRAS(2), JUN(3), MAP2K1(10), MAP2K2(1), MAP2K4(8), MAP3K1(7), MAPK1(2), MAPK3(3), MAPK8(2), MEF2A(2), MEF2B(2), MEF2C(6), MEF2D(4), PAK1(9), PRKCA(10), PTK2(6), PTK2B(14), RAF1(6), SHC1(6), SOS1(17), SRC(2), SYT1(6)	26949018	255	193	200	50	27	78	32	46	72	0	0.0167	1.000	1.000
239	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(12), ALDH4A1(6), ALDH5A1(2), CAD(25), CPS1(71), EARS2(5), EPRS(27), GAD1(7), GAD2(27), GCLC(13), GFPT1(8), GFPT2(10), GLS(8), GLS2(6), GLUD1(4), GLUD2(15), GLUL(6), GMPS(9), GNPNAT1(1), GOT1(3), GOT2(6), GPT2(5), GSR(5), GSS(4), NADSYN1(2), NAGK(6), PPAT(1), QARS(6)	31784864	300	193	299	75	27	122	53	35	62	1	0.0507	1.000	1.000
240	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	CAD(25), CANT1(3), CDA(2), CTPS2(6), DCK(2), DCTD(4), DHODH(1), DPYD(24), DPYS(22), ENTPD1(7), ITPA(1), NT5E(5), NT5M(3), NUDT2(3), POLB(4), POLD1(7), POLD2(3), POLE(31), POLG(12), POLL(7), POLQ(36), POLR1B(11), POLR2A(11), POLR2B(10), POLR2C(4), POLR2D(3), POLR2E(2), POLR2F(1), POLR2G(1), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(2), POLRMT(8), RRM1(6), RRM2(6), TK1(1), TK2(1), TXNRD1(7), TYMS(3), UCK2(10), UMPS(4), UNG(5), UPB1(2), UPP1(6)	45844839	316	193	314	95	39	126	70	31	48	2	0.394	1.000	1.000
241	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ADH1A(8), ADH1B(12), ADH4(4), ADH5(2), ADH6(8), ADH7(11), ADHFE1(5), ALDH1A3(4), ALDH3A1(5), ALDH3B1(2), ALDH3B2(4), AOC2(6), AOC3(11), AOX1(22), CARM1(4), COMT(1), DBH(12), DCT(16), DDC(8), ECH1(1), ESCO1(10), ESCO2(4), FAH(2), GOT1(3), GOT2(6), GSTZ1(2), HGD(5), HPD(2), LCMT1(5), LCMT2(7), MAOA(5), MAOB(3), METTL2B(5), METTL6(1), NAT6(1), PNMT(1), PNPLA3(4), PRMT2(2), PRMT3(8), PRMT5(7), PRMT6(7), PRMT7(4), PRMT8(13), TAT(9), TH(7), TPO(33), TYR(29), TYRP1(5), WBSCR22(3)	47774422	339	192	334	110	56	123	57	38	65	0	0.435	1.000	1.000
242	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	AKT1(3), AKT2(7), AKT3(7), BCR(11), BLNK(2), BTK(25), CD19(5), CSK(2), DAG1(3), EPHB2(10), GRB2(6), ITPKA(2), ITPKB(7), LYN(6), MAP2K1(10), MAP2K2(1), MAPK1(2), NFAT5(13), NFKB1(6), NFKB2(5), NFKBIA(4), NFKBIB(3), NFKBIE(2), NFKBIL1(1), PI3(1), PIK3CA(30), PIK3CD(4), PIK3R1(4), PLCG2(18), PPP1R13B(7), RAF1(6), SERPINA4(16), SHC1(6), SOS1(17), SOS2(13), SYK(5), VAV1(8)	42056644	278	191	260	83	29	102	71	27	49	0	0.390	1.000	1.000
243	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	AGMAT(2), ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH4A1(6), ALDH9A1(3), AMD1(2), AOC2(6), AOC3(11), ARG1(2), ASL(4), CKB(1), CKM(4), CKMT1A(1), CKMT1B(1), CKMT2(2), CPS1(71), DAO(7), GATM(8), GLUD1(4), GOT1(3), GOT2(6), MAOA(5), MAOB(3), NOS1(29), NOS3(12), OAT(3), ODC1(1), OTC(10), P4HA1(5), P4HA2(5), P4HA3(4), P4HB(5), PYCR1(1), RARS(6), SMS(3)	35307606	282	190	280	90	37	101	55	38	50	1	0.391	1.000	1.000
244	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(7), AKR1B10(10), B4GALT1(1), B4GALT2(4), G6PC(7), G6PC2(8), GAA(12), GALK1(3), GALK2(3), GALT(5), GANC(3), GCK(6), GLA(9), GLB1(3), HK1(12), HK2(11), HK3(22), HSD3B7(7), LCT(50), MGAM(51), PFKL(9), PFKM(7), PFKP(5), PGM1(3), PGM3(3), RDH11(4), RDH12(3), RDH13(1), RDH14(2), UGP2(4)	30815039	275	190	274	82	46	115	57	20	37	0	0.131	1.000	1.000
245	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	B2M(9), CALR(2), CANX(5), CD4(8), CD8A(4), CD8B(5), CIITA(5), CREB1(2), CTSB(2), CTSS(3), HLA-A(8), HLA-B(4), HLA-C(5), HLA-DMA(4), HLA-DMB(3), HLA-DOA(2), HLA-DPA1(1), HLA-DQA2(3), HLA-DQB1(4), HLA-DRA(3), HLA-DRB1(5), HLA-E(2), HLA-G(5), HSP90AA1(8), HSP90AB1(9), HSPA5(3), IFNA1(2), IFNA10(7), IFNA14(4), IFNA16(8), IFNA17(5), IFNA2(5), IFNA21(3), IFNA4(4), IFNA5(5), IFNA6(7), IFNA7(6), IFNA8(7), KIR2DL3(8), KIR3DL1(17), KIR3DL2(5), KIR3DL3(2), KLRC1(5), KLRC2(2), KLRC3(5), KLRC4(2), KLRD1(2), LGMN(4), LTA(3), NFYA(1), NFYB(1), NFYC(6), PDIA3(4), PSME1(2), PSME2(3), RFX5(9), RFXANK(1), TAP1(1), TAP2(8), TAPBP(4)	37467191	272	190	264	86	22	108	59	34	49	0	0.613	1.000	1.000
246	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	AANAT(1), ACAT1(2), ACAT2(2), ACMSD(2), ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH9A1(3), AOC2(6), AOC3(11), AOX1(22), ASMT(13), CAT(3), CYP19A1(4), CYP1A1(9), CYP1A2(3), CYP2A13(13), CYP2A6(6), CYP2A7(7), CYP2B6(10), CYP2C18(7), CYP2C19(13), CYP2C8(2), CYP2C9(8), CYP2D6(1), CYP2E1(7), CYP2F1(3), CYP2J2(1), CYP3A4(4), CYP3A5(5), CYP3A7(7), CYP4B1(14), CYP51A1(5), DDC(8), ECHS1(4), EHHADH(13), GCDH(7), HAAO(1), HADHA(3), KMO(9), KYNU(17), MAOA(5), MAOB(3), SDS(4), TDO2(9), TPH1(8), WARS(6), WARS2(7)	44374676	344	190	340	115	43	127	70	44	60	0	0.628	1.000	1.000
247	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CALM1(3), CALM2(1), CAMK1(1), CAMK1G(2), ELK1(3), FPR1(10), GNA15(1), GNB1(2), GNGT1(6), HRAS(2), MAP2K1(10), MAP2K2(1), MAP2K3(13), MAP2K6(5), MAP3K1(7), MAPK1(2), MAPK14(4), MAPK3(3), NCF1(3), NCF2(8), NFATC1(9), NFATC2(15), NFATC3(15), NFATC4(11), NFKB1(6), NFKBIA(4), PAK1(9), PIK3C2G(19), PLCB1(52), PPP3CA(14), PPP3CB(3), PPP3CC(3), RAF1(6), RELA(3), SYT1(6)	30659672	262	189	252	67	31	113	45	20	53	0	0.0544	1.000	1.000
248	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOA(4), ALDOB(8), ALDOC(2), DLAT(10), DLD(9), ENO1(7), ENO2(2), ENO3(3), FBP1(2), FBP2(2), G6PC(7), GAPDH(5), GAPDHS(10), GCK(6), GOT1(3), GOT2(6), GPI(8), HK1(12), HK2(11), HK3(22), LDHA(10), LDHAL6B(3), LDHB(4), LDHC(6), MDH1(3), MDH2(3), PC(9), PCK1(21), PDHA1(5), PDHA2(29), PDHX(4), PFKL(9), PFKM(7), PFKP(5), PGAM1(1), PGAM2(1), PGK1(4), PGK2(27), PKLR(16), TNFAIP1(1), TPI1(9)	34015838	316	189	315	95	52	131	50	34	49	0	0.115	1.000	1.000
249	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(7), ADRBK2(7), ARRB2(4), CALM1(3), CALM2(1), CALML3(3), CALML6(1), CAMK2A(3), CAMK2B(16), CAMK2D(7), CLCA1(14), CLCA2(29), CLCA4(30), CNGA3(15), CNGA4(15), CNGB1(10), GNAL(5), GUCA1A(7), GUCA1B(4), GUCA1C(7), PDC(1), PDE1C(28), PRKACA(3), PRKACB(9), PRKACG(4), PRKG1(20), PRKG2(15), PRKX(3)	24535411	271	187	270	86	28	118	53	22	50	0	0.440	1.000	1.000
250	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(4), AGPAT1(9), AGPAT2(3), AGPAT3(4), AGPAT4(9), AGPS(6), CDIPT(1), CDS1(3), CDS2(4), CHAT(22), CHKA(4), CHKB(4), CLC(3), CPT1B(6), DGKA(7), DGKB(40), DGKD(10), DGKE(5), DGKG(15), DGKH(14), DGKQ(1), DGKZ(5), ETNK1(5), GNPAT(5), GPD1(3), GPD2(9), LCAT(6), LGALS13(5), PAFAH1B1(1), PAFAH2(3), PCYT1A(2), PCYT1B(3), PEMT(2), PISD(2), PLA2G1B(2), PLA2G2A(5), PLA2G2E(2), PLA2G3(6), PLA2G4A(21), PLA2G6(3), PLCB2(12), PLCG1(7), PLCG2(18), PPAP2A(2), PPAP2B(3), PPAP2C(1)	39734673	307	186	301	99	45	100	77	26	58	1	0.552	1.000	1.000
251	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	26	AKT1(3), APC(33), AXIN1(7), CCND1(3), CD14(1), CTNNB1(20), DVL1(5), FZD1(6), GJA1(11), GNAI1(10), GSK3B(4), IRAK1(6), LBP(8), LEF1(12), LY96(3), MYD88(1), NFKB1(6), PDPK1(3), PIK3CA(30), PIK3R1(4), PPP2CA(1), RELA(3), TLR4(64), TOLLIP(2), WNT1(6)	24506970	252	185	232	55	24	116	43	22	47	0	0.0125	1.000	1.000
252	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	ACVR1(7), APC(33), ATF2(10), AXIN1(7), BMP10(11), BMP2(1), BMP4(6), BMP5(6), BMP7(12), BMPR1A(4), BMPR2(10), CHRD(13), CTNNB1(20), DVL1(5), FZD1(6), GATA4(7), GSK3B(4), MAP3K7(10), MEF2C(6), MYL2(8), NKX2-5(8), NOG(1), NPPA(3), NPPB(3), RFC1(13), TGFB1(3), TGFB2(10), TGFBR1(7), TGFBR2(7), TGFBR3(19), WNT1(6)	29159681	266	183	255	66	36	103	49	27	51	0	0.103	1.000	1.000
253	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(23), GABBR1(8), GPRC5A(3), GPRC5B(14), GPRC5C(10), GPRC5D(2), GRM1(48), GRM2(7), GRM3(19), GRM4(21), GRM5(40), GRM7(43), GRM8(52)	16886110	290	183	287	86	49	128	67	17	28	1	0.0406	1.000	1.000
254	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA2(2), ACADL(4), ACADM(8), ACADS(1), ACADSB(2), ACADVL(2), ACAT1(2), ACAT2(2), ACOX1(5), ACOX3(8), ACSL1(12), ACSL3(4), ACSL4(7), ACSL5(3), ACSL6(15), ADH1A(8), ADH1B(12), ADH4(4), ADH5(2), ADH6(8), ADH7(11), ADHFE1(5), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH7A1(3), ALDH9A1(3), CPT1A(11), CPT1B(6), CPT1C(13), CPT2(3), CYP4A11(8), CYP4A22(1), ECHS1(4), EHHADH(13), GCDH(7), HADH(2), HADHA(3), HADHB(10), HSD17B10(2), HSD17B4(8)	39393905	254	183	248	66	35	88	49	32	50	0	0.0878	1.000	1.000
255	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	CBL(10), EGF(13), EGFR(86), GRB2(6), HRAS(2), MAP2K1(10), MAPK1(2), MAPK3(3), PTPRB(50), RAF1(6), RASA1(11), SHC1(6), SOS1(17), SPRY1(3), SPRY2(5), SPRY3(9), SPRY4(4), SRC(2)	20159948	245	183	191	53	20	67	44	46	68	0	0.142	1.000	1.000
256	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(38), AR(10), ESR1(12), ESR2(6), HNF4A(21), NPM1(5), NR0B1(14), NR1D1(2), NR1D2(1), NR1H2(5), NR1H3(4), NR1I2(4), NR1I3(9), NR2C2(2), NR2E1(9), NR2F1(7), NR2F2(1), NR2F6(1), NR3C1(8), NR4A1(5), NR4A2(18), NR5A1(6), NR5A2(14), PGR(15), PPARA(4), PPARD(6), PPARG(8), RARA(7), RARB(7), RARG(3), ROR1(13), RORA(9), RORC(1), RXRA(1), RXRB(3), RXRG(18), THRA(5), THRB(4), VDR(4)	33642017	310	182	309	108	45	126	66	20	52	1	0.662	1.000	1.000
257	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(3), AKT2(7), AKT3(7), ARHGEF11(24), BCL2(5), CDC42(1), DLG4(7), GNA13(6), LPA(47), MAP2K4(8), MAP3K1(7), MAP3K5(14), MAPK8(2), NFKB1(6), NFKB2(5), NFKBIA(4), NFKBIB(3), NFKBIE(2), NFKBIL1(1), PDK1(6), PHKA2(14), PI3(1), PIK3CB(8), PLD1(19), PLD2(7), PLD3(4), PTK2(6), RDX(2), ROCK1(19), ROCK2(9), SERPINA4(16), SRF(1), TBXA2R(1)	39339807	272	182	268	72	25	115	50	32	50	0	0.170	1.000	1.000
258	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	ACTR2(4), ACTR3(2), AKT1(3), ANGPTL2(5), DAG1(3), DGKA(7), GCA(3), ITGA9(6), ITPKA(2), ITPKB(7), ITPR1(20), ITPR2(40), ITPR3(21), MAP2K1(10), MAPK1(2), MAPK3(3), NR1I3(9), PAK1(9), PDE3A(30), PDE3B(16), PI3(1), PIK3C2G(19), PIK3CA(30), PIK3CD(4), PIK3R1(4), PSME1(2), RIPK3(5), RPS4X(2), SGCB(4), VASP(2)	39085275	275	181	261	64	29	98	60	28	59	1	0.0300	1.000	1.000
259	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(14), AADAC(5), ABAT(12), ACADS(1), ACAT1(2), ACAT2(2), ACSM1(10), AKR1B10(10), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH5A1(2), ALDH7A1(3), ALDH9A1(3), BDH1(4), BDH2(2), DDHD1(11), ECHS1(4), EHHADH(13), GAD1(7), GAD2(27), HADH(2), HADHA(3), HMGCL(1), HMGCS1(11), HMGCS2(7), HSD17B10(2), HSD17B4(8), HSD3B7(7), ILVBL(3), L2HGDH(6), OXCT1(7), OXCT2(2), PDHA1(5), PDHA2(29), PLA1A(6), PPME1(6), PRDX6(5), RDH11(4), RDH12(3), RDH13(1), RDH14(2)	32639019	282	180	280	88	32	105	64	26	53	2	0.489	1.000	1.000
260	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM1(3), CALM2(1), DLG4(7), GRIN1(9), GRIN2A(61), GRIN2B(53), GRIN2C(8), GRIN2D(9), NOS1(29), PPP3CA(14), PPP3CB(3), PPP3CC(3), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PRKCA(10), SYT1(6)	20405710	240	180	234	75	45	99	46	15	33	2	0.196	1.000	1.000
261	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(20), ACACB(28), ACAT1(2), ACAT2(2), ACOT12(11), ACSS1(5), ACSS2(4), ACYP2(1), AKR1B1(7), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH7A1(3), ALDH9A1(3), DLAT(10), DLD(9), GLO1(1), GRHPR(4), HAGH(4), HAGHL(3), LDHA(10), LDHAL6A(1), LDHAL6B(3), LDHB(4), LDHC(6), LDHD(2), MDH1(3), MDH2(3), ME1(3), ME2(9), ME3(8), PC(9), PCK1(21), PCK2(4), PDHA1(5), PDHA2(29), PKLR(16)	37616402	283	179	282	93	43	109	49	30	52	0	0.563	1.000	1.000
262	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	ARHGDIB(2), CASP2(13), CASP3(5), CASP8(6), CRADD(3), DFFA(3), DFFB(4), FADD(2), JUN(3), LMNA(2), LMNB1(5), LMNB2(5), MADD(22), MAP2K4(8), MAP3K1(7), MAP3K7(10), MAPK8(2), PAK1(9), PAK2(3), PRKDC(50), RB1(33), RIPK1(11), SPTAN1(21), TNF(2), TRADD(2), TRAF2(5)	30950025	238	179	233	47	19	59	57	26	77	0	0.0295	1.000	1.000
263	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	ARFIP2(5), CDK5(3), CDK5R1(3), CHN1(8), LIMK1(3), MAP3K1(7), MYL2(8), MYLK(26), NCF2(8), PAK1(9), PDGFRA(41), PIK3CA(30), PIK3R1(4), PLD1(19), PPP1R12B(15), RALBP1(3), RPS6KB1(3), TRIO(37), VAV1(8), WASF1(10)	28260607	250	178	238	64	22	104	57	18	47	2	0.106	1.000	1.000
264	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	A1BG(4), AKT1(3), AKT2(7), AKT3(7), BTK(25), CDKN2A(22), DAPP1(3), GRB2(6), GSK3A(1), GSK3B(4), IARS(9), IGFBP1(6), INPP5D(11), PDK1(6), PIK3CA(30), PPP1R13B(7), PTEN(11), RPS6KA1(6), RPS6KA2(8), RPS6KA3(6), RPS6KB1(3), SFN(1), SHC1(6), SOS1(17), SOS2(13), TEC(12), YWHAB(1), YWHAE(1), YWHAG(3), YWHAH(1), YWHAQ(4), YWHAZ(2)	28989848	246	178	229	54	23	102	56	19	46	0	0.0340	1.000	1.000
265	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	112	ATP12A(13), ATP4A(16), ATP5A1(4), ATP5B(3), ATP5C1(4), ATP5E(1), ATP5F1(3), ATP5G3(2), ATP5J2(3), ATP5L(3), ATP5O(1), ATP6AP1(3), ATP6V0A1(6), ATP6V0A2(4), ATP6V0A4(8), ATP6V0B(2), ATP6V0C(4), ATP6V0D1(2), ATP6V0D2(8), ATP6V1A(6), ATP6V1B1(3), ATP6V1B2(5), ATP6V1C1(7), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1E2(5), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3), COX10(4), COX4I1(3), COX5A(1), COX5B(2), COX6B1(2), COX6B2(1), COX6C(1), COX7B2(3), COX8A(1), COX8C(2), CYC1(7), LHPP(3), NDUFA1(2), NDUFA10(5), NDUFA11(1), NDUFA12(5), NDUFA13(1), NDUFA4(2), NDUFA5(2), NDUFA6(1), NDUFA7(1), NDUFA8(5), NDUFA9(4), NDUFB1(1), NDUFB10(3), NDUFB11(6), NDUFB2(2), NDUFB4(1), NDUFB5(6), NDUFB6(2), NDUFB8(1), NDUFB9(2), NDUFC2(3), NDUFS1(10), NDUFS2(4), NDUFS3(3), NDUFS4(3), NDUFS5(1), NDUFS6(2), NDUFS7(1), NDUFS8(2), NDUFV1(2), NDUFV2(1), NDUFV3(1), PPA1(2), SDHA(8), SDHB(1), SDHD(3), TCIRG1(2), UQCRB(5), UQCRC1(2), UQCRC2(5), UQCRFS1(3), UQCRH(3), UQCRQ(2)	44713921	281	177	278	104	47	92	57	24	59	2	0.863	1.000	1.000
266	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(6), ARG1(2), ASL(4), ASS1(5), CKB(1), CKM(4), CKMT1A(1), CKMT1B(1), CKMT2(2), CPS1(71), DAO(7), EPRS(27), GATM(8), GLUD1(4), GLUD2(15), GOT1(3), GOT2(6), LAP3(4), NOS1(29), NOS3(12), OAT(3), OTC(10), P4HA1(5), P4HA2(5), P4HA3(4), PARS2(1), PRODH(4), PYCR1(1), PYCR2(6), PYCRL(1), RARS(6), RARS2(6)	28625139	264	177	261	73	29	111	51	29	43	1	0.114	1.000	1.000
267	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(5), ALOX12(8), ALOX12B(7), ALOX15(5), ALOX15B(6), ALOX5(10), CYP2B6(10), CYP2C18(7), CYP2C19(13), CYP2C8(2), CYP2C9(8), CYP2E1(7), CYP2J2(1), CYP2U1(2), CYP4A11(8), CYP4A22(1), CYP4F2(15), CYP4F3(16), DHRS4(1), EPHX2(3), GGT1(1), GPX3(2), GPX5(7), GPX6(7), GPX7(4), LTA4H(3), PLA2G12A(4), PLA2G12B(3), PLA2G1B(2), PLA2G2A(5), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(6), PLA2G4A(21), PLA2G6(3), PTGDS(4), PTGIS(12), PTGS1(18), PTGS2(12), TBXAS1(11)	31159882	266	177	263	76	38	104	60	25	39	0	0.121	1.000	1.000
268	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(9), CAPN1(2), CAPN2(5), CAPNS1(1), CAPNS2(2), CXCR3(3), EGF(13), EGFR(86), HRAS(2), ITGA1(14), ITGB1(6), MAPK1(2), MAPK3(3), MYL2(8), MYLK(26), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PTK2(6), PXN(1), TLN1(15)	26295190	228	177	179	57	20	69	38	44	56	1	0.283	1.000	1.000
269	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(12), ALDH4A1(6), ALDH5A1(2), CAD(25), CPS1(71), EPRS(27), GAD1(7), GAD2(27), GCLC(13), GFPT1(8), GLS(8), GLS2(6), GLUD1(4), GLUL(6), GMPS(9), GOT1(3), GOT2(6), GPT2(5), GSS(4), NADSYN1(2), PPAT(1), QARS(6)	26707796	258	176	257	66	23	103	44	31	56	1	0.115	1.000	1.000
270	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(26), CALM1(3), CALM2(1), CREB1(2), ELK1(3), FOS(3), GNAI1(10), GNAQ(5), GNAS(29), GNB1(2), GNGT1(6), HRAS(2), JUN(3), MAP2K1(10), MAPK3(3), NFATC1(9), NFATC2(15), NFATC3(15), NFATC4(11), PLCG1(7), PPP3CA(14), PPP3CB(3), PPP3CC(3), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PRKCA(10), RAF1(6), RPS6KA3(6), SYT1(6)	27925393	237	176	228	65	49	99	37	17	33	2	0.0958	1.000	1.000
271	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CD14(1), CHUK(7), ELK1(3), FOS(3), IKBKB(9), IRAK1(6), JUN(3), LY96(3), MAP2K3(13), MAP2K4(8), MAP2K6(5), MAP3K1(7), MAP3K7(10), MAPK14(4), MAPK8(2), MYD88(1), NFKB1(6), NFKBIA(4), PPARA(4), RELA(3), TLR10(16), TLR2(10), TLR3(4), TLR4(64), TLR6(11), TLR7(17), TLR9(9), TOLLIP(2), TRAF6(6)	29367557	241	176	240	80	15	100	47	26	53	0	0.752	1.000	1.000
272	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	24	ATM(53), BMPR1B(7), CCND2(4), CDK4(3), CDKN1B(5), DAZL(2), DMC1(1), EGR1(6), ESR2(6), FSHR(37), GJA4(6), INHA(1), LHCGR(14), MLH1(8), MSH5(8), NCOR1(23), NR5A1(6), NRIP1(13), PGR(15), PRLR(18), PTGER2(4), SMPD1(3), VDR(4), ZP2(5)	28059230	252	175	247	55	36	92	51	28	43	2	0.0177	1.000	1.000
273	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(4), AKR1D1(12), ARSB(6), ARSD(6), ARSE(5), CYP11B1(27), CYP11B2(24), HSD11B1(9), HSD17B2(6), HSD17B3(3), HSD3B1(6), HSD3B2(15), SRD5A1(4), STS(9), SULT1E1(11), SULT2A1(6), UGT1A1(12), UGT1A10(9), UGT1A3(6), UGT1A4(4), UGT1A5(8), UGT1A6(9), UGT1A7(7), UGT1A9(7), UGT2B15(14), UGT2B4(28)	22158661	257	174	254	75	21	117	64	24	30	1	0.196	1.000	1.000
274	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(4), AGTR2(6), CALM1(3), CALM2(1), CAMK2A(3), CAMK2B(16), CAMK2D(7), CDK5(3), F2(9), FYN(8), GNA11(4), GNAI1(10), GNB1(2), GNGT1(6), GRB2(6), HRAS(2), JAK2(16), MAP2K1(10), MAP2K2(1), MAPK1(2), MAPK14(4), MAPK3(3), MAPK8(2), MAPT(15), MYLK(26), PLCG1(7), PRKCA(10), PTK2B(14), RAF1(6), SHC1(6), SOS1(17), STAT1(7), STAT3(11), STAT5A(3), SYT1(6)	33357943	256	174	251	77	45	87	46	28	50	0	0.295	1.000	1.000
275	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(7), B4GALT1(1), B4GALT2(4), FBP2(2), G6PC(7), GAA(12), GALK1(3), GALK2(3), GALT(5), GANAB(9), GCK(6), GLA(9), GLB1(3), HK1(12), HK2(11), HK3(22), LCT(50), MGAM(51), PFKM(7), PFKP(5), PGM1(3), PGM3(3)	26076697	235	174	234	67	37	102	48	16	32	0	0.0743	1.000	1.000
276	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B3GNT6(5), B4GALT5(6), C1GALT1(5), C1GALT1C1(4), GALNT1(6), GALNT10(6), GALNT11(3), GALNT12(3), GALNT13(35), GALNT14(24), GALNT2(11), GALNT3(12), GALNT4(4), GALNT5(10), GALNT6(5), GALNT7(9), GALNT8(19), GALNTL5(5), GCNT1(8), GCNT3(2), GCNT4(9), OGT(19), ST3GAL1(4), ST3GAL2(4), ST6GALNAC1(8), WBSCR17(33)	26072743	259	174	255	98	35	99	69	22	34	0	0.966	1.000	1.000
277	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	ARHGDIB(2), CASP10(7), CASP3(5), CASP6(3), CASP7(3), CASP8(6), CFLAR(2), DAXX(8), DFFA(3), DFFB(4), FADD(2), FAF1(10), JUN(3), LMNA(2), LMNB1(5), LMNB2(5), MAP2K4(8), MAP3K1(7), MAP3K7(10), MAPK8(2), PAK1(9), PAK2(3), PRKDC(50), PTPN13(21), RB1(33), RIPK2(2), SPTAN1(21)	32622253	236	173	231	55	13	60	55	28	80	0	0.312	1.000	1.000
278	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	AGXT(8), AGXT2(13), AKR1B10(10), ALAS1(2), ALAS2(6), AMT(1), AOC2(6), AOC3(11), BHMT(7), CBS(1), CHDH(2), CHKA(4), CHKB(4), CTH(2), DAO(7), DLD(9), DMGDH(11), GARS(3), GATM(8), GCAT(7), GLDC(26), GNMT(1), HSD3B7(7), MAOA(5), MAOB(3), PEMT(2), PHGDH(7), PIPOX(2), PISD(2), PSAT1(5), PSPH(6), RDH11(4), RDH12(3), RDH13(1), RDH14(2), SARDH(10), SARS(5), SARS2(4), SDS(4), SHMT1(2), SHMT2(2), TARS(14), TARS2(11)	34156007	250	173	249	82	37	91	53	27	41	1	0.383	1.000	1.000
279	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(2), BTK(25), CALM1(3), CALM2(1), CD79A(2), CD79B(2), ELK1(3), FOS(3), GRB2(6), HRAS(2), JUN(3), LYN(6), MAP2K1(10), MAP3K1(7), MAPK14(4), MAPK3(3), MAPK8(2), NFATC1(9), NFATC2(15), NFATC3(15), NFATC4(11), PLCG1(7), PPP3CA(14), PPP3CB(3), PPP3CC(3), PRKCA(10), RAF1(6), SHC1(6), SOS1(17), SYK(5), SYT1(6), VAV1(8)	30760682	219	172	211	57	32	85	44	18	40	0	0.0989	1.000	1.000
280	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(7), DCXR(1), GUSB(5), RPE(3), UGDH(6), UGP2(4), UGT1A1(12), UGT1A10(9), UGT1A3(6), UGT1A4(4), UGT1A5(8), UGT1A6(9), UGT1A7(7), UGT1A9(7), UGT2A1(16), UGT2A3(11), UGT2B10(9), UGT2B11(23), UGT2B15(14), UGT2B17(12), UGT2B28(23), UGT2B4(28), UGT2B7(14), XYLB(6)	22159835	244	171	242	65	9	118	59	22	36	0	0.252	1.000	1.000
281	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(9), ACTN1(7), ACTN2(43), BCAR1(3), BCR(11), CAPN1(2), CAPNS1(1), CAPNS2(2), CAV1(1), CRKL(4), CSK(2), FYN(8), GRB2(6), HRAS(2), ITGA1(14), ITGB1(6), JUN(3), MAP2K1(10), MAP2K2(1), MAPK1(2), MAPK3(3), MAPK8(2), PPP1R12B(15), PTK2(6), PXN(1), RAF1(6), RAP1A(1), ROCK1(19), SHC1(6), SOS1(17), SRC(2), TLN1(15), VCL(8), ZYX(6)	37582153	244	171	238	85	34	84	53	32	41	0	0.761	1.000	1.000
282	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	ADCY1(26), ARHGEF1(5), F2(9), F2R(10), F2RL3(2), GNA12(1), GNA13(6), GNAI1(10), GNAQ(5), GNB1(2), GNGT1(6), MAP3K7(10), PIK3CA(30), PIK3R1(4), PLCB1(52), PPP1R12B(15), PRKCA(10), PTK2B(14), ROCK1(19)	20726309	236	171	224	49	27	106	41	19	42	1	0.00266	1.000	1.000
283	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT1(3), AKT2(7), AKT3(7), ANKRD6(2), APC(33), AXIN1(7), AXIN2(5), CER1(7), CSNK1A1(2), CTNNB1(20), DACT1(24), DKK1(3), DKK2(14), DKK4(2), DVL1(5), FSTL1(4), GSK3A(1), GSK3B(4), LRP1(36), MVP(6), NKD1(6), NKD2(8), PIN1(1), PSEN1(6), PTPRA(11), SENP2(6), SFRP1(2), TSHB(5), WIF1(3)	32236645	240	171	230	73	34	105	38	21	42	0	0.373	1.000	1.000
284	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(4), AARS2(9), CARS(4), CARS2(3), DARS(3), DARS2(4), EARS2(5), EPRS(27), FARS2(5), FARSA(5), FARSB(5), GARS(3), HARS(5), HARS2(4), IARS(9), IARS2(15), KARS(8), LARS(14), LARS2(2), MARS(5), MARS2(13), MTFMT(1), NARS(4), NARS2(6), PARS2(1), QARS(6), RARS(6), RARS2(6), SARS(5), SARS2(4), TARS(14), TARS2(11), VARS(10), VARS2(2), WARS(6), WARS2(7), YARS(3), YARS2(10)	43790134	254	170	251	63	27	95	56	24	52	0	0.0730	1.000	1.000
285	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(5), ELK1(3), FOS(3), GRB2(6), HRAS(2), JAK1(11), JUN(3), MAP2K1(10), MAP2K4(8), MAP3K1(7), MAPK3(3), MAPK8(2), PDGFA(5), PDGFRA(41), PIK3CA(30), PIK3R1(4), PLCG1(7), PRKCA(10), RAF1(6), RASA1(11), SHC1(6), SOS1(17), SRF(1), STAT1(7), STAT3(11), STAT5A(3)	28197351	222	170	207	56	26	73	46	29	47	1	0.184	1.000	1.000
286	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(2), ALG10(15), ALG10B(8), ALG11(7), ALG12(3), ALG13(15), ALG14(1), ALG2(3), ALG3(4), ALG5(1), ALG6(1), ALG8(3), ALG9(5), B4GALT1(1), B4GALT2(4), B4GALT3(2), DAD1(2), DDOST(1), DHDDS(2), DOLPP1(1), DPAGT1(5), DPM1(5), FUT8(7), GANAB(9), MAN1A1(3), MAN1A2(7), MAN1B1(4), MAN1C1(3), MAN2A1(20), MGAT1(7), MGAT2(5), MGAT3(15), MGAT4A(3), MGAT4B(7), MGAT5(13), MGAT5B(22), RFT1(4), RPN1(3), RPN2(4), ST6GAL1(4), STT3B(4)	33965732	235	169	235	63	28	96	43	28	40	0	0.159	1.000	1.000
287	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	A4GALT(1), B3GALNT1(2), B3GALT1(5), B3GALT2(4), B3GALT4(1), B3GALT5(3), B3GNT1(3), B3GNT2(4), B3GNT3(5), B3GNT4(2), B3GNT5(5), B4GALNT1(9), B4GALT1(1), B4GALT2(4), B4GALT3(2), B4GALT4(2), B4GALT6(5), FUT1(4), FUT2(1), FUT3(5), FUT5(3), FUT6(4), FUT7(3), FUT9(15), GBGT1(2), GCNT2(5), PIGA(6), PIGB(5), PIGC(1), PIGG(13), PIGK(3), PIGL(4), PIGM(2), PIGN(10), PIGO(11), PIGP(2), PIGQ(6), PIGS(4), PIGT(7), PIGU(1), PIGV(4), PIGX(4), PIGZ(3), ST3GAL1(4), ST3GAL2(4), ST3GAL3(4), ST3GAL4(4), ST3GAL5(3), ST3GAL6(6), ST6GALNAC3(15), ST6GALNAC4(1), ST6GALNAC5(11), ST6GALNAC6(2), ST8SIA1(6), ST8SIA5(12), UGCG(2)	38645581	260	167	258	98	39	93	58	26	44	0	0.828	1.000	1.000
288	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(6), ARSB(6), FUCA1(2), FUCA2(3), GALNS(3), GBA(7), GLB1(3), GNS(1), GUSB(5), HEXA(6), HGSNAT(6), HPSE(4), HPSE2(16), HYAL1(3), HYAL2(3), IDS(7), IDUA(1), LCT(50), MAN2B1(5), MAN2B2(7), MAN2C1(7), MANBA(11), NAGLU(5), NEU1(2), NEU2(7), NEU3(5), NEU4(13), SPAM1(25)	27360330	219	167	218	78	30	98	35	27	29	0	0.682	1.000	1.000
289	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(4), ACTR3(2), ARHGAP1(5), ARHGAP4(14), ARHGAP5(17), ARHGAP6(17), ARHGEF1(5), ARHGEF11(24), ARHGEF5(4), ARPC1A(3), ARPC1B(4), ARPC2(3), ARPC3(2), BAIAP2(3), DIAPH1(3), GSN(4), LIMK1(3), MYL2(8), MYLK(26), OPHN1(16), PFN1(1), PIP5K1A(6), PIP5K1B(6), PPP1R12B(15), ROCK1(19), SRC(2), TLN1(15), VCL(8)	36548965	239	167	237	65	34	86	41	26	52	0	0.109	1.000	1.000
290	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(22), CARM1(4), CCND1(3), CREBBP(30), EP300(11), ERCC3(5), ESR1(12), GRIP1(13), GTF2A1(3), GTF2E1(8), GTF2F1(4), HDAC1(4), HDAC2(8), HDAC3(3), HDAC4(19), HDAC5(5), HDAC6(12), MEF2C(6), NCOR2(30), NR0B1(14), NRIP1(13), PELP1(10), POLR2A(11), TBP(1)	36770103	251	166	251	73	38	94	64	14	41	0	0.268	1.000	1.000
291	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(12), ACAA2(2), ACADM(8), ACADS(1), ACAT1(2), ACAT2(2), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH6A1(2), ALDH7A1(3), ALDH9A1(3), AOX1(22), AUH(2), BCAT1(3), BCAT2(2), BCKDHA(1), BCKDHB(14), DBT(8), DLD(9), ECHS1(4), EHHADH(13), HADH(2), HADHA(3), HADHB(10), HIBADH(2), HIBCH(4), HMGCL(1), HMGCS1(11), HMGCS2(7), HSD17B10(2), HSD17B4(8), IVD(4), MCCC1(5), MCCC2(5), MCEE(2), MUT(13), OXCT1(7), OXCT2(2), PCCA(6), PCCB(3)	34662383	240	166	237	66	23	76	66	26	48	1	0.396	1.000	1.000
292	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(13), C5(6), C6(29), C7(39), ICAM1(2), IL1A(4), IL6(2), ITGA4(38), ITGAL(26), ITGB1(6), ITGB2(8), SELP(29), SELPLG(2), TNF(2), VCAM1(28)	19976575	234	166	233	68	15	101	59	23	35	1	0.451	1.000	1.000
293	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(10), BAX(3), BCL2(5), BCL2A1(1), BCL2L1(3), CASP1(8), CASP10(7), CASP2(13), CASP3(5), CASP4(6), CASP6(3), CASP7(3), CASP8(6), CASP9(6), CD40(3), CD40LG(9), CRADD(3), CYCS(2), DAXX(8), DFFA(3), DFFB(4), FADD(2), FAS(4), FASLG(10), IKBKE(9), LTA(3), MCL1(1), NFKB1(6), NFKBIA(4), NGFR(5), NR3C1(8), NTRK1(14), PTPN13(21), RIPK1(11), TFG(4), TNF(2), TNFRSF1B(2), TRADD(2), TRAF1(2), TRAF2(5), TRAF3(4), TRAF6(6)	34956034	236	164	235	90	15	96	56	27	41	1	0.958	1.000	1.000
294	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	ARNT(5), EIF1(2), EIF2B1(2), EIF2B2(3), EIF2B3(4), EIF2B4(3), EIF2S2(3), EIF2S3(3), ELAVL1(5), FLT1(31), FLT4(20), HIF1A(2), HRAS(2), KDR(56), NOS3(12), PIK3CA(30), PIK3R1(4), PLCG1(7), PRKCA(10), PTK2(6), PXN(1), SHC1(6), VHL(1)	27087280	218	164	205	57	30	89	40	21	38	0	0.123	1.000	1.000
295	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(4), CDC7(6), CDK2(1), CDT1(1), DIAPH2(18), GMNN(1), MCM10(10), MCM2(5), MCM3(12), MCM4(11), MCM5(10), MCM6(16), MCM7(5), NACA(15), PCNA(1), POLA2(7), POLD1(7), POLD2(3), POLD3(2), POLD4(2), POLE(31), POLE2(1), PRIM1(3), RFC1(13), RFC2(4), RFC3(3), RFC4(7), RFC5(3), RPA1(2), RPA2(2), RPA3(1), RPA4(8), UBA52(1), UBC(14)	40583197	230	163	230	64	28	79	54	24	44	1	0.436	1.000	1.000
296	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	ADCY1(26), AKT1(3), ASAH1(3), GNAI1(10), GNB1(2), GNGT1(6), ITGAV(14), ITGB3(13), MAPK1(2), MAPK3(3), PDGFA(5), PDGFRA(41), PIK3CA(30), PIK3R1(4), PLCB1(52), PRKCA(10), PTK2(6), SMPD1(3), SRC(2)	22064930	235	163	223	65	22	102	51	20	38	2	0.152	1.000	1.000
297	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	AGXT(8), AGXT2(13), ALAS1(2), ALAS2(6), AMT(1), AOC2(6), AOC3(11), ATP6V0C(4), BHMT(7), CBS(1), CHDH(2), CHKA(4), CHKB(4), CPT1B(6), CTH(2), DAO(7), DLD(9), DMGDH(11), GARS(3), GATM(8), GCAT(7), GLDC(26), MAOA(5), MAOB(3), PEMT(2), PISD(2), PLCB2(12), PLCG1(7), PLCG2(18), PSPH(6), SARDH(10), SARS(5), SHMT1(2), SHMT2(2), TARS(14)	33546941	236	163	234	81	41	76	53	29	36	1	0.551	1.000	1.000
298	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(4), AARS2(9), ABAT(12), ACY3(4), ADSL(2), ADSS(6), ADSSL1(4), AGXT(8), AGXT2(13), ASL(4), ASNS(8), ASPA(5), ASRGL1(3), ASS1(5), CAD(25), DARS(3), DARS2(4), DDO(5), DLAT(10), DLD(9), GAD1(7), GAD2(27), GOT1(3), GOT2(6), GPT2(5), NARS(4), NARS2(6), PC(9), PDHA1(5), PDHA2(29)	30242893	244	162	244	66	35	94	49	23	42	1	0.0995	1.000	1.000
299	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ACY3(4), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH3B1(2), ALDH3B2(4), ALDH7A1(3), ALDH9A1(3), AMDHD1(4), AOC2(6), AOC3(11), ASPA(5), CARM1(4), CNDP1(10), DDC(8), FTCD(8), HAL(5), HARS(5), HARS2(4), HDC(16), LCMT1(5), LCMT2(7), MAOA(5), MAOB(3), METTL2B(5), METTL6(1), PRMT2(2), PRMT3(8), PRMT5(7), PRMT6(7), PRMT7(4), PRMT8(13), PRPS1(3), PRPS2(4), UROC1(14), WBSCR22(3)	31764646	223	162	221	69	44	73	43	24	39	0	0.235	1.000	1.000
300	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(7), AKR1B10(10), ALDOA(4), ALDOB(8), ALDOC(2), FBP1(2), FBP2(2), FPGT(9), FUK(6), GMDS(9), GMPPA(7), HK1(12), HK2(11), HK3(22), HSD3B7(7), KHK(3), LHPP(3), MPI(4), MTMR1(11), MTMR2(2), MTMR6(9), PFKFB1(10), PFKFB2(2), PFKFB3(7), PFKFB4(6), PFKL(9), PFKM(7), PFKP(5), PGM2(8), PHPT1(1), PMM1(3), PMM2(1), RDH11(4), RDH12(3), RDH13(1), RDH14(2), SORD(2), TPI1(9), TSTA3(1)	29574893	231	160	230	64	46	85	44	18	38	0	0.0514	1.000	1.000
301	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(3), AASDH(15), AASDHPPT(4), AASS(20), ACAT1(2), ACAT2(2), ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH9A1(3), ATP6V0C(4), BBOX1(11), DLST(5), DOT1L(14), ECHS1(4), EHHADH(13), EHMT1(15), EHMT2(9), GCDH(7), HADHA(3), PLOD1(5), PLOD2(12), PLOD3(10), SDS(4), SHMT1(2), SHMT2(2), TMLHE(9)	29411929	224	160	221	62	30	87	49	28	29	1	0.157	1.000	1.000
302	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT1(3), AKT2(7), AKT3(7), CISH(1), GRB2(6), IARS(9), IL13RA1(3), IL2RG(5), IL4(1), IL4R(10), INPP5D(11), JAK1(11), JAK2(16), JAK3(10), NR0B2(3), PI3(1), PIK3CA(30), PPP1R13B(7), RPS6KB1(3), SERPINA4(16), SHC1(6), SOS1(17), SOS2(13), SRC(2), STAT6(2), TYK2(5)	29558969	205	160	191	65	23	85	47	23	27	0	0.625	1.000	1.000
303	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(10), CD2(6), CD33(13), CD5(7), IFNA1(2), IFNB1(7), IFNG(7), IL10(2), IL12A(2), IL12B(3), IL13(2), IL3(4), IL4(1), IL5(2), ITGAX(52), TLR2(10), TLR4(64), TLR7(17), TLR9(9)	15018623	220	159	219	65	19	111	35	21	32	2	0.0772	1.000	1.000
304	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(20), ACAT1(2), ACAT2(2), ACYP2(1), ADH5(2), AKR1B1(7), ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH9A1(3), DLAT(10), DLD(9), GLO1(1), GRHPR(4), HAGH(4), HAGHL(3), LDHA(10), LDHB(4), LDHC(6), LDHD(2), MDH1(3), MDH2(3), ME1(3), ME2(9), ME3(8), PC(9), PCK1(21), PDHA1(5), PDHA2(29), PKLR(16)	29693112	242	158	241	64	34	93	45	28	42	0	0.0983	1.000	1.000
305	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(5), ALOX12(8), ALOX15(5), ALOX5(10), CYP4F2(15), CYP4F3(16), EPX(14), GGT1(1), LPO(7), LTA4H(3), MPO(15), PLA2G1B(2), PLA2G2A(5), PLA2G2E(2), PLA2G3(6), PLA2G4A(21), PLA2G6(3), PRDX1(4), PRDX2(2), PRDX5(1), PRDX6(5), PTGDS(4), PTGIS(12), PTGS1(18), PTGS2(12), TBXAS1(11), TPO(33)	22337017	240	157	236	76	38	81	61	25	35	0	0.344	1.000	1.000
306	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2A1(3), GTF2A1L(10), GTF2A2(1), GTF2B(1), GTF2E1(8), GTF2E2(2), GTF2F1(4), GTF2H1(4), GTF2H3(1), GTF2H4(1), GTF2I(7), GTF2IRD1(10), STON1(11), TAF1(22), TAF1L(65), TAF2(13), TAF4(13), TAF4B(6), TAF5(5), TAF5L(9), TAF6(3), TAF6L(3), TAF7(3), TAF7L(6), TAF9(3), TAF9B(5), TBPL1(1), TBPL2(4)	29022582	224	156	224	51	28	81	49	21	43	2	0.0807	1.000	1.000
307	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	ATF2(10), CDC42(1), CREB1(2), DAXX(8), DDIT3(2), ELK1(3), GRB2(6), HMGN1(1), HRAS(2), HSPB1(1), HSPB2(1), MAP2K4(8), MAP2K6(5), MAP3K1(7), MAP3K5(14), MAP3K7(10), MAP3K9(17), MAPK14(4), MAPKAPK2(2), MAPKAPK5(5), MAX(8), MEF2A(2), MEF2B(2), MEF2C(6), MEF2D(4), MKNK1(4), MYC(4), PLA2G4A(21), RIPK1(11), RPS6KA5(10), SHC1(6), STAT1(7), TGFB1(3), TGFB2(10), TGFBR1(7), TRADD(2), TRAF2(5)	29475986	221	156	220	49	21	88	46	22	44	0	0.0357	1.000	1.000
308	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	ANKHD1(21), EEF1A2(8), EEF1B2(7), EEF1D(2), EEF1G(2), EEF2(7), EEF2K(7), EIF1AX(3), EIF2AK1(12), EIF2AK2(5), EIF2AK3(12), EIF2B1(2), EIF2B2(3), EIF2B3(4), EIF2B4(3), EIF2S2(3), EIF2S3(3), EIF4A1(2), EIF4A2(7), EIF4E(4), EIF4EBP2(1), EIF4G1(19), EIF4G3(20), EIF5(1), EIF5A(2), EIF5B(14), GSPT2(8), PABPC1(5), PABPC3(15), PAIP1(6), SLC35A4(1)	34830836	209	155	208	54	16	79	55	25	34	0	0.246	1.000	1.000
309	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA2(2), ACAD8(7), ACAD9(5), ADH1A(8), ADH1B(12), ADH4(4), ADH5(2), ADH6(8), ADH7(11), ADHFE1(5), AKR1B10(10), AKR1C4(4), AKR1D1(12), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH7A1(3), ALDH9A1(3), BAAT(9), CEL(8), CYP27A1(5), CYP7A1(8), HADHB(10), HSD3B7(7), LIPA(2), RDH11(4), RDH12(3), RDH13(1), RDH14(2), SLC27A5(7), SOAT1(8), SOAT2(2), SRD5A1(4)	25394461	206	153	203	63	19	81	48	22	36	0	0.368	1.000	1.000
310	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSA(2), ARSD(6), ARSE(5), ASAH1(3), B4GALT6(5), CERK(4), DEGS1(2), DEGS2(1), ENPP7(11), GAL3ST1(7), GALC(9), GBA(7), GLA(9), GLB1(3), LCT(50), NEU1(2), NEU2(7), NEU3(5), NEU4(13), PPAP2A(2), PPAP2B(3), PPAP2C(1), SGMS1(4), SGMS2(3), SGPP1(3), SGPP2(2), SMPD1(3), SMPD3(6), SMPD4(13), SPHK2(4), SPTLC1(3), SPTLC2(3), UGCG(2), UGT8(8)	28419660	211	152	209	67	37	99	42	11	22	0	0.198	1.000	1.000
311	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ADH1A(8), ADH1B(12), ADH4(4), ADH6(8), ADH7(11), ADHFE1(5), ALDH1A3(4), ALDH3A1(5), ALDH3B1(2), ALDH3B2(4), AOC2(6), AOC3(11), AOX1(22), COMT(1), DBH(12), DCT(16), DDC(8), FAH(2), GOT1(3), GOT2(6), GSTZ1(2), HGD(5), HPD(2), MAOA(5), MAOB(3), PNMT(1), TAT(9), TH(7), TPO(33), TYR(29)	25458965	246	152	243	80	38	97	35	28	48	0	0.292	1.000	1.000
312	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(17), DIAPH1(3), FYN(8), GSN(4), HRAS(2), ITGA1(14), ITGB1(6), MAP2K1(10), MAPK1(2), MAPK3(3), MYL2(8), MYLK(26), PFN1(1), PIK3CA(30), PIK3R1(4), PTK2(6), PXN(1), RAF1(6), ROCK1(19), SHC1(6), SRC(2), TLN1(15)	30127071	193	151	180	54	22	75	36	26	34	0	0.334	1.000	1.000
313	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(9), AGT(4), AGTR1(9), AGTR2(6), CMA1(8), COL4A1(36), COL4A2(40), COL4A3(16), COL4A4(22), COL4A5(50), COL4A6(28), REN(6)	20378769	234	149	233	81	20	133	35	13	32	1	0.955	1.000	1.000
314	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	ADCY1(26), AKT1(3), CAMK2A(3), CAMK2B(16), CAMK2D(7), CREB1(2), GNAS(29), GRB2(6), HRAS(2), MAPK1(2), MAPK14(4), MAPK3(3), PIK3CA(30), PIK3R1(4), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PRKCA(10), RPS6KA1(6), RPS6KA5(10), SOS1(17)	23289810	204	149	188	58	36	83	39	21	23	2	0.361	1.000	1.000
315	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	25	GH1(7), GHR(19), GRB2(6), HRAS(2), INSR(10), IRS1(20), JAK2(16), MAP2K1(10), MAPK1(2), MAPK3(3), PIK3CA(30), PIK3R1(4), PLCG1(7), PRKCA(10), PTPN6(6), RAF1(6), RPS6KA1(6), SHC1(6), SLC2A4(4), SOS1(17), SRF(1), STAT5A(3), STAT5B(8)	26607771	203	149	188	53	29	77	45	25	27	0	0.110	1.000	1.000
316	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(12), ACACA(20), ACACB(28), ACADM(8), ACAT1(2), ACAT2(2), ACSS1(5), ACSS2(4), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH6A1(2), ALDH7A1(3), ALDH9A1(3), ECHS1(4), EHHADH(13), HADHA(3), HIBCH(4), LDHA(10), LDHAL6A(1), LDHAL6B(3), LDHB(4), LDHC(6), MCEE(2), MLYCD(2), MUT(13), PCCA(6), PCCB(3), SUCLA2(5), SUCLG1(5), SUCLG2(1)	31991829	204	149	203	69	26	74	43	17	44	0	0.819	1.000	1.000
317	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	CSNK2A1(5), FOS(3), GRB2(6), HRAS(2), JAK2(16), JUN(3), MAP2K1(10), MAPK3(3), MPL(5), PIK3CA(30), PIK3R1(4), PLCG1(7), PRKCA(10), RAF1(6), RASA1(11), SHC1(6), SOS1(17), STAT1(7), STAT3(11), STAT5A(3), STAT5B(8), THPO(7)	24178108	180	149	165	48	19	62	35	26	38	0	0.353	1.000	1.000
318	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(6), ACTG2(10), ADCY3(7), ADCY9(12), ARF1(1), ARF3(1), ARF5(2), ARF6(1), ARL4D(4), ATP6V0A1(6), ATP6V0A2(4), ATP6V0A4(8), ATP6V0B(2), ATP6V0C(4), ATP6V0D1(2), ATP6V0D2(8), ATP6V1A(6), ATP6V1C1(7), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1E2(5), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3), ERO1L(5), GNAS(29), PDIA4(8), PLCG1(7), PLCG2(18), PRKCA(10), SEC61A1(5), SEC61A2(6), SEC61G(3), TRIM23(4)	29658651	204	148	198	65	34	79	40	16	34	1	0.397	1.000	1.000
319	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	ATF2(10), BCR(11), BLNK(2), ELK1(3), FOS(3), GRB2(6), HRAS(2), JUN(3), LYN(6), MAP2K1(10), MAP3K1(7), MAPK1(2), MAPK3(3), MAPK8IP3(7), PAPPA(32), RPS6KA1(6), RPS6KA3(6), SHC1(6), SOS1(17), SYK(5), VAV1(8), VAV2(8), VAV3(32)	25525164	195	148	191	51	25	71	39	24	35	1	0.120	1.000	1.000
320	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(11), GABRA1(20), GABRA2(31), GABRA3(15), GABRA4(39), GABRA5(27), GABRA6(28), GPHN(5), NSF(4), SRC(2), UBQLN1(6)	9626774	188	146	185	62	23	91	33	19	22	0	0.612	1.000	1.000
321	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(19), POLA2(7), POLB(4), POLD1(7), POLD2(3), POLD3(2), POLD4(2), POLE(31), POLE2(1), POLE4(1), POLG(12), POLG2(3), POLH(1), POLI(3), POLK(3), POLL(7), POLM(6), POLQ(36), PRIM1(3), PRIM2(14), REV1(10), REV3L(20), RFC5(3)	32635969	198	146	197	49	22	80	47	23	25	1	0.204	1.000	1.000
322	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(9), F2R(10), F2RL3(2), GNAI1(10), GNB1(2), GNGT1(6), HRAS(2), ITGA1(14), ITGB1(6), MAP2K1(10), MAPK1(2), MAPK3(3), PLA2G4A(21), PLCB1(52), PRKCA(10), PTGS1(18), PTK2(6), RAF1(6), SRC(2), SYK(5), TBXAS1(11)	19547606	207	146	202	46	21	94	41	20	31	0	0.0126	1.000	1.000
323	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	26	AKT1(3), AKT2(7), AKT3(7), BCL2(5), GRB2(6), GSK3A(1), GSK3B(4), IL4R(10), IRS1(20), JAK1(11), JAK3(10), MAP4K1(12), MAPK1(2), MAPK3(3), PDK1(6), PIK3CA(30), PIK3CD(4), PIK3R1(4), PPP1R13B(7), RAF1(6), SHC1(6), SOS1(17), SOS2(13), STAT6(2)	28596494	196	145	181	64	24	79	45	20	28	0	0.649	1.000	1.000
324	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	ATF1(1), BRAF(44), CREB1(2), CREB5(18), DUSP4(2), DUSP6(4), DUSP9(6), EEF2K(7), EIF4E(4), GRB2(6), MAP2K1(10), MAP2K2(1), MAP3K8(4), MAPK1(2), MAPK3(3), MKNK1(4), MKNK2(2), MOS(9), NFKB1(6), RAP1A(1), RPS6KA1(6), RPS6KA2(8), RPS6KA3(6), SHC1(6), SOS1(17), SOS2(13), TRAF3(4)	23617530	196	145	170	42	22	78	47	15	33	1	0.0184	1.000	1.000
325	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(26), CD3D(2), CD3E(2), CD4(8), CREBBP(30), CSK(2), GNAS(29), GNB1(2), GNGT1(6), HLA-DRA(3), HLA-DRB1(5), LCK(9), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PTPRC(41), ZAP70(9)	18346764	198	144	191	55	40	70	37	12	37	2	0.243	1.000	1.000
326	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCL11(2), CCR3(4), GNAQ(5), GNAS(29), GNB1(2), GNGT1(6), HRAS(2), LIMK1(3), MAP2K1(10), MAPK1(2), MAPK3(3), MYL2(8), NOX1(8), PIK3C2G(19), PLCB1(52), PPP1R12B(15), PRKCA(10), PTK2(6), RAF1(6), ROCK2(9)	20171859	201	144	194	43	32	84	39	18	28	0	0.0272	1.000	1.000
327	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(26), CD3D(2), CD3E(2), CD4(8), CREBBP(30), CSK(2), GNAS(29), GNB1(2), GNGT1(6), HLA-DRA(3), HLA-DRB1(5), LCK(9), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PTPRC(41), ZAP70(9)	18346764	198	144	191	55	40	70	37	12	37	2	0.243	1.000	1.000
328	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(1), ASNS(8), ASRGL1(3), CA1(6), CA12(2), CA13(1), CA14(3), CA2(2), CA3(10), CA4(6), CA5A(2), CA5B(3), CA6(4), CA7(1), CA8(5), CA9(9), CPS1(71), CTH(2), GLS(8), GLS2(6), GLUD1(4), GLUD2(15), GLUL(6), HAL(5)	17120398	183	144	182	58	17	80	31	23	32	0	0.590	1.000	1.000
329	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(12), ANAPC10(1), ANAPC11(1), ANAPC2(5), ANAPC4(6), ANAPC5(8), ANAPC7(5), BTRC(12), CDC16(2), CDC20(8), CDC23(3), CDC27(7), CUL1(14), CUL2(8), CUL3(13), FBXW11(2), FBXW7(15), FZR1(3), ITCH(8), SKP1(4), SKP2(3), SMURF1(8), SMURF2(4), TCEB1(2), UBA1(4), UBE2C(3), UBE2D1(1), UBE2D2(1), UBE2D3(3), UBE2D4(1), UBE2E2(4), UBE2E3(6), VHL(1), WWP1(13), WWP2(7)	32170628	198	144	197	46	27	61	41	31	38	0	0.0754	1.000	1.000
330	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(4), AKT1(3), AKT2(7), AKT3(7), DAG1(3), GNAQ(5), ITPKA(2), ITPKB(7), ITPR1(20), ITPR2(40), ITPR3(21), NFKB1(6), NFKB2(5), NFKBIA(4), NFKBIB(3), NFKBIE(2), NFKBIL1(1), PDK1(6), PHKA2(14), PIK3CB(8), PITX2(8), PLD1(19), PLD2(7), PLD3(4), VN1R1(2)	35811416	208	144	207	59	23	79	43	19	43	1	0.281	1.000	1.000
331	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(3), CAMK2B(16), CAMK2D(7), DAG1(3), ITPKA(2), ITPKB(7), ITPR1(20), ITPR2(40), ITPR3(21), NFAT5(13), PDE6A(17), PDE6B(15), PDE6C(12), PDE6G(3), SLC6A13(12), TF(13)	28645135	204	144	203	62	28	73	49	20	33	1	0.384	1.000	1.000
332	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA2(2), ACADL(4), ACADM(8), ACADS(1), ACADSB(2), ACAT1(2), ACAT2(2), ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH6A1(2), ALDH9A1(3), AOX1(22), BCAT1(3), BCKDHA(1), BCKDHB(14), ECHS1(4), EHHADH(13), HADHA(3), HADHB(10), HIBADH(2), HMGCL(1), IVD(4), MCCC1(5), MCCC2(5), MCEE(2), MUT(13), OXCT1(7), PCCA(6), PCCB(3), SDS(4)	28978649	194	143	192	56	16	66	47	25	40	0	0.541	1.000	1.000
333	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	34	AKT1(3), BCL2(5), BCL2L1(3), CBL(10), CFLAR(2), CRKL(4), E2F1(3), FOS(3), GRB2(6), HRAS(2), IL2RA(6), IL2RB(7), IL2RG(5), IRS1(20), JAK1(11), JAK3(10), MAPK1(2), MAPK3(3), MYC(4), NMI(2), PIK3CA(30), PIK3R1(4), PTPN6(6), RAF1(6), RPS6KB1(3), SHC1(6), SOS1(17), STAT5A(3), STAT5B(8), SYK(5)	28960398	199	142	184	61	28	72	51	23	25	0	0.466	1.000	1.000
334	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(12), ACADL(4), ACADM(8), ACADSB(2), ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH9A1(3), AOC2(6), AOC3(11), CNDP1(10), DPYD(24), DPYS(22), ECHS1(4), EHHADH(13), GAD1(7), GAD2(27), HADHA(3), MLYCD(2), SDS(4), SMS(3), UPB1(2)	23401329	213	141	211	52	26	84	39	22	41	1	0.0375	1.000	1.000
335	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(33), AXIN1(7), CREBBP(30), CTNNB1(20), DVL1(5), EP300(11), FZD1(6), GSK3B(4), HDAC1(4), LDB1(3), LEF1(12), PITX2(8), TRRAP(51), WNT1(6)	26615618	200	140	191	40	40	65	41	17	37	0	0.00489	1.000	1.000
336	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(36), COL4A2(40), COL4A3(16), COL4A4(22), COL4A5(50), COL4A6(28), P4HB(5), SLC23A1(3), SLC23A2(8), SLC2A1(1), SLC2A3(10)	20161255	219	140	218	71	23	119	34	10	32	1	0.753	1.000	1.000
337	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QA(7), C1QB(11), C1R(4), C1S(4), C2(10), C3(13), C5(6), C6(29), C7(39), C8A(18), C9(20), MASP1(13), MASP2(8), MBL2(13)	17155255	195	139	193	60	19	90	33	20	32	1	0.478	1.000	1.000
338	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(13), ATP5E(1), ATP5O(1), ATP6AP1(3), ATP6V0A1(6), ATP6V0A4(8), ATP6V0B(2), ATP6V0C(4), ATP6V0D1(2), ATP6V1A(6), ATP6V1B1(3), ATP6V1B2(5), ATP6V1C1(7), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3), ATP7A(29), ATP7B(22), COX10(4), COX4I1(3), COX5A(1), COX5B(2), COX6B1(2), COX6C(1), COX8A(1), NDUFA1(2), NDUFA10(5), NDUFA11(1), NDUFA4(2), NDUFA5(2), NDUFA8(5), NDUFB2(2), NDUFB4(1), NDUFB5(6), NDUFB6(2), NDUFS1(10), NDUFS2(4), NDUFV1(2), NDUFV2(1), SDHA(8), SDHB(1), SHMT1(2), UQCRB(5), UQCRC1(2), UQCRFS1(3), UQCRH(3)	30733115	208	139	205	78	34	79	30	22	41	2	0.800	1.000	1.000
339	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(14), ABAT(12), ACADS(1), ACAT1(2), ACAT2(2), ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH5A1(2), ALDH9A1(3), ECHS1(4), EHHADH(13), GAD1(7), GAD2(27), HADHA(3), HMGCL(1), L2HGDH(6), OXCT1(7), PDHA1(5), PDHA2(29), SDHB(1), SDS(4)	20733189	189	138	188	58	22	70	40	20	36	1	0.460	1.000	1.000
340	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	30	AKT1(3), CABIN1(10), CALM1(3), CALM2(1), CAMK1(1), CAMK1G(2), HDAC5(5), IGF1(4), IGF1R(8), INSR(10), MAP2K6(5), MAPK14(4), MAPK7(7), MEF2A(2), MEF2B(2), MEF2C(6), MEF2D(4), MYOD1(7), NFATC1(9), NFATC2(15), PIK3CA(30), PIK3R1(4), PPP3CA(14), PPP3CB(3), PPP3CC(3), SYT1(6), YWHAH(1)	27758602	169	138	155	51	20	72	27	15	35	0	0.247	1.000	1.000
341	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(3), ACO1(5), ACO2(3), CLYBL(5), CS(2), DLD(9), DLST(5), FH(13), IDH1(6), IDH2(2), IDH3A(1), IDH3B(4), IDH3G(5), MDH1(3), MDH2(3), OGDH(10), OGDHL(35), PC(9), PCK1(21), PCK2(4), SDHA(8), SDHB(1), SDHD(3), SUCLA2(5), SUCLG1(5), SUCLG2(1)	24111107	171	138	170	65	28	61	24	25	33	0	0.761	1.000	1.000
342	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(9), EPHA4(18), EPHB1(44), FYN(8), ITGA1(14), ITGB1(6), L1CAM(42), LYN(6), RAP1B(2), SELP(29)	12772799	178	137	177	47	28	68	33	22	25	2	0.131	1.000	1.000
343	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	BCL2(5), CREBBP(30), EP300(11), FYN(8), IL2RG(5), IL7(2), IL7R(21), JAK1(11), JAK3(10), LCK(9), NMI(2), PIK3CA(30), PIK3R1(4), PTK2B(14), STAT5A(3), STAT5B(8)	22465484	173	137	163	49	22	63	37	19	32	0	0.319	1.000	1.000
344	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(12), ACACA(20), ACADL(4), ACADM(8), ACADSB(2), ACAT1(2), ACAT2(2), ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH6A1(2), ALDH9A1(3), ECHS1(4), EHHADH(13), HADHA(3), LDHA(10), LDHB(4), LDHC(6), MCEE(2), MLYCD(2), MUT(13), PCCA(6), PCCB(3), SDS(4), SUCLA2(5), SUCLG1(5), SUCLG2(1)	26690520	182	137	181	50	19	62	40	19	42	0	0.418	1.000	1.000
345	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(3), ATF1(1), CDC42(1), CREB1(2), CREB5(18), DUSP1(1), DUSP10(11), EEF2K(7), EIF4E(4), ELK1(3), GADD45A(2), HSPB1(1), IL1R1(2), MAP2K3(13), MAP2K4(8), MAP2K6(5), MAP3K10(4), MAP3K4(21), MAP3K5(14), MAP3K7(10), MAPK1(2), MAPK12(2), MAPK13(1), MAPK14(4), MAPKAPK2(2), MAPKAPK5(5), MKNK1(4), MKNK2(2), MYEF2(12), NFKB1(6), NR2C2(2), SRF(1), TRAF6(6)	26680683	180	137	178	47	16	76	36	13	39	0	0.177	1.000	1.000
346	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	AKT1(3), EIF4A1(2), EIF4A2(7), EIF4E(4), EIF4G1(19), EIF4G2(5), EIF4G3(20), GHR(19), IRS1(20), MAPK1(2), MAPK14(4), MAPK3(3), MKNK1(4), PABPC1(5), PDK2(3), PDPK1(3), PIK3CA(30), PIK3R1(4), PRKCA(10), PTEN(11), RPS6KB1(3)	22744566	181	136	169	50	16	79	43	16	27	0	0.400	1.000	1.000
347	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	AKT1(3), BCL2(5), BCR(11), CRKL(4), FOS(3), GRB2(6), HRAS(2), JAK2(16), JUN(3), MAP2K1(10), MAP2K4(8), MAP3K1(7), MAPK3(3), MAPK8(2), MYC(4), PIK3CA(30), PIK3R1(4), RAF1(6), SOS1(17), STAT1(7), STAT5A(3), STAT5B(8)	22565531	162	136	146	36	15	57	42	21	27	0	0.0626	1.000	1.000
348	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA1(1), ANXA2(2), ANXA3(6), ANXA4(5), ANXA5(6), ANXA6(8), CYP11A1(5), EDN1(1), EDNRA(3), EDNRB(16), HPGD(5), HSD11B1(9), PLA2G4A(21), PRL(3), PTGDR(8), PTGDS(4), PTGER2(4), PTGER4(7), PTGFR(12), PTGIR(6), PTGIS(12), PTGS1(18), PTGS2(12), S100A6(1), SCGB1A1(2), TBXAS1(11)	16642391	188	135	186	48	25	67	44	17	33	2	0.0756	1.000	1.000
349	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QA(7), C1QB(11), C1R(4), C1S(4), C2(10), C3(13), C5(6), C6(29), C7(39), C8A(18), C8B(20), C9(20), MASP1(13)	16788403	194	134	192	56	18	89	33	23	30	1	0.313	1.000	1.000
350	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ACY1(2), AGMAT(2), ALDH18A1(3), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH7A1(3), ALDH9A1(3), AMD1(2), AOC2(6), AOC3(11), ARG1(2), ASL(4), ASS1(5), CPS1(71), GATM(8), MAOA(5), MAOB(3), NAGS(1), ODC1(1), OTC(10), SAT1(3), SMS(3), SRM(2)	23626242	180	133	179	60	22	68	35	25	29	1	0.593	1.000	1.000
351	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(12), ACADM(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH7A1(3), ALDH9A1(3), AOC2(6), AOC3(11), CNDP1(10), DPYD(24), DPYS(22), ECHS1(4), EHHADH(13), GAD1(7), GAD2(27), HADHA(3), HIBCH(4), MLYCD(2), SMS(3), SRM(2), UPB1(2)	21711201	196	133	194	48	26	78	39	17	35	1	0.0425	1.000	1.000
352	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(1), ASNS(8), CA1(6), CA12(2), CA14(3), CA2(2), CA3(10), CA4(6), CA5A(2), CA5B(3), CA6(4), CA7(1), CA8(5), CA9(9), CPS1(71), CTH(2), GLS(8), GLS2(6), GLUD1(4), GLUL(6), HAL(5)	15322390	164	133	163	49	17	67	27	22	31	0	0.468	1.000	1.000
353	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	39	ARNTL(2), AZIN1(4), BTG1(3), CBX3(4), CLOCK(4), CRY1(7), CRY2(6), DAZAP2(1), DNAJA1(3), EIF4G2(5), ETV6(5), GFRA1(20), GSTM3(2), GSTP1(2), HERPUD1(2), HSPA8(10), IDI1(2), MYF6(11), NCKAP1(11), NCOA4(6), NR1D2(1), PER1(10), PER2(11), PPP1R3C(3), PPP2CB(3), PSMA4(2), PURA(2), SF3A3(2), SUMO3(5), TOB1(4), TUBB3(3), UGP2(4), VAPA(2), ZFR(10)	29207628	172	132	171	45	20	60	39	16	36	1	0.315	1.000	1.000
354	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(20), GABRA2(31), GABRA3(15), GABRA4(39), GABRA5(27), GABRA6(28), PRKCE(5), SOD1(1)	6364786	166	132	163	55	16	85	30	16	18	1	0.611	1.000	1.000
355	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(4), ACP2(4), ACP5(4), ACPP(8), ACPT(7), ALPI(9), ALPL(3), ALPP(13), ALPPL2(4), CYP19A1(4), CYP1A1(9), CYP1A2(3), CYP2A13(13), CYP2A6(6), CYP2A7(7), CYP2B6(10), CYP2C18(7), CYP2C19(13), CYP2C8(2), CYP2C9(8), CYP2D6(1), CYP2E1(7), CYP2F1(3), CYP2J2(1), CYP3A4(4), CYP3A5(5), CYP3A7(7), CYP4B1(14), CYP51A1(5), PON1(3)	23543387	188	132	188	72	25	72	38	23	30	0	0.818	1.000	1.000
356	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(33), AXIN1(7), BTRC(12), CCND1(3), CREBBP(30), CSNK1A1(2), CSNK1D(7), CSNK2A1(5), CTBP1(2), CTNNB1(20), DVL1(5), FZD1(6), GSK3B(4), HDAC1(4), MAP3K7(10), MYC(4), NLK(3), PPARD(6), PPP2CA(1), TLE1(5), WIF1(3), WNT1(6)	23421841	178	131	169	33	28	68	33	16	33	0	0.00510	1.000	1.000
357	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(7), ICAM1(2), ITGA4(38), ITGAL(26), ITGAM(24), ITGB1(6), ITGB2(8), SELE(17), SELL(9), SELP(29)	12885072	166	130	164	51	11	81	39	12	23	0	0.547	1.000	1.000
358	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(1), BLVRA(3), BLVRB(2), CP(11), CPOX(4), EPRS(27), FECH(4), GUSB(5), HCCS(3), HMBS(5), HMOX1(3), PPOX(7), UGT1A1(12), UGT1A10(9), UGT1A3(6), UGT1A4(4), UGT1A5(8), UGT1A6(9), UGT1A7(7), UGT1A9(7), UGT2B15(14), UGT2B4(28), UROS(2)	22183495	181	130	180	51	9	88	47	12	25	0	0.356	1.000	1.000
359	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(7), ACTN2(43), BCAR1(3), CSK(2), CTNNA1(9), CTNNA2(65), CTNNB1(20), PTK2(6), PXN(1), SRC(2), VCL(8)	15247578	166	128	158	51	19	71	34	19	23	0	0.311	1.000	1.000
360	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(8), EXT2(11), EXTL1(8), EXTL2(3), EXTL3(13), GLCE(4), HS2ST1(1), HS3ST1(8), HS3ST2(7), HS3ST3A1(7), HS3ST5(18), HS6ST1(5), HS6ST2(3), HS6ST3(12), NDST1(6), NDST2(6), NDST3(16), NDST4(36)	16652374	172	128	170	49	31	58	41	23	17	2	0.217	1.000	1.000
361	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(17), ARHGEF1(5), GNA12(1), GNA13(6), GNAQ(5), GNB1(2), GNGT1(6), MYL2(8), MYLK(26), PLCB1(52), PPP1R12B(15), PRKCA(10), ROCK1(19)	16694901	172	128	171	40	18	73	28	20	33	0	0.0587	1.000	1.000
362	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(3), CHIA(5), CHIT1(11), CMAS(10), CYB5R1(1), GFPT1(8), GFPT2(10), GNE(2), GNPDA1(2), GNPDA2(2), GNPNAT1(1), HEXA(6), HK1(12), HK2(11), HK3(22), LHPP(3), MTMR1(11), MTMR2(2), MTMR6(9), NAGK(6), NANS(2), NPL(4), PGM3(3), PHPT1(1), RENBP(7), UAP1(7)	23026251	161	127	160	42	29	63	26	19	24	0	0.100	1.000	1.000
363	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(3), CALM1(3), CALM2(1), CRKL(4), GNAQ(5), GRB2(6), HRAS(2), JUN(3), MAP2K1(10), MAP2K2(1), MAP2K3(13), MAP2K4(8), MAP3K1(7), MAPK1(2), MAPK14(4), MAPK3(3), MAPK8(2), PAK1(9), PLCG1(7), PRKCA(10), PTK2B(14), RAF1(6), SHC1(6), SOS1(17), SRC(2), SYT1(6)	22790036	154	127	147	48	24	53	30	12	35	0	0.575	1.000	1.000
364	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOA(4), ALDOB(8), ALDOC(2), FBP1(2), FBP2(2), GOT1(3), GOT2(6), GPT2(5), MDH1(3), MDH2(3), ME1(3), ME3(8), PGK1(4), PGK2(27), PKLR(16), RPE(3), RPIA(8), TKT(3), TKTL1(14), TKTL2(26), TPI1(9)	16185365	159	126	159	34	18	62	33	18	28	0	0.00969	1.000	1.000
365	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	CSNK2A1(5), ELK1(3), FOS(3), GRB2(6), HRAS(2), IGF1(4), IGF1R(8), IRS1(20), JUN(3), MAP2K1(10), MAPK3(3), MAPK8(2), PIK3CA(30), PIK3R1(4), PTPN11(9), RAF1(6), RASA1(11), SHC1(6), SOS1(17), SRF(1)	20012310	153	126	138	39	17	58	31	18	29	0	0.218	1.000	1.000
366	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	AKT1(3), EIF4A1(2), EIF4A2(7), EIF4B(7), EIF4E(4), EIF4G1(19), EIF4G2(5), EIF4G3(20), MKNK1(4), PDK2(3), PDPK1(3), PIK3CA(30), PIK3R1(4), PPP2CA(1), PTEN(11), RPS6(3), RPS6KB1(3), TSC1(10), TSC2(13)	22071035	152	126	140	39	12	57	40	14	29	0	0.298	1.000	1.000
367	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	CHUK(7), FADD(2), IKBKB(9), IL1A(4), IL1R1(2), IRAK1(6), MAP3K1(7), MAP3K7(10), MYD88(1), NFKB1(6), NFKBIA(4), RELA(3), RIPK1(11), TLR4(64), TNF(2), TNFAIP3(6), TNFRSF1B(2), TRADD(2), TRAF6(6)	19518685	154	126	153	48	5	65	34	19	31	0	0.602	1.000	1.000
368	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	32	DUSP1(1), GORASP1(2), MAP2K4(8), MAP2K7(7), MAPK1(2), MAPK10(6), MAPK12(2), MAPK13(1), MAPK14(4), MAPK3(3), MAPK8(2), MAPK8IP1(4), MAPK8IP2(2), MAPK8IP3(7), MAPK9(8), MAPKAPK5(5), NFKB1(6), NFKB2(5), NFKBIA(4), NFKBIB(3), NFKBIE(2), NFKBIL1(1), PIK3CA(30), PIK3CD(4), PIK3R1(4), SYT1(6), TRAF2(5), TRAF3(4), TRAF5(5), TRAF6(6)	26390548	149	125	139	51	19	53	29	16	32	0	0.625	1.000	1.000
369	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	CSNK2A1(5), ELK1(3), FOS(3), GRB2(6), HRAS(2), INSR(10), IRS1(20), JUN(3), MAP2K1(10), MAPK3(3), MAPK8(2), PIK3CA(30), PIK3R1(4), PTPN11(9), RAF1(6), RASA1(11), SHC1(6), SLC2A4(4), SOS1(17), SRF(1)	20534203	155	124	140	44	19	54	34	21	27	0	0.385	1.000	1.000
370	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(25), DLG4(7), EPHB2(10), F2(9), F2RL1(2), F2RL2(12), F2RL3(2), JUN(3), MAP2K5(4), MAPK1(2), MAPK7(7), MAPK8(2), MYEF2(12), PLD1(19), PLD2(7), PLD3(4), PTK2(6), RAF1(6), RASAL1(10), SRC(2), TEC(12), VAV1(8)	21952267	171	124	169	38	21	70	41	8	31	0	0.0142	1.000	1.000
371	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(7), ALDOA(4), ALDOB(8), ALDOC(2), FBP1(2), FBP2(2), FPGT(9), GCK(6), GMDS(9), GMPPA(7), HK1(12), HK2(11), HK3(22), KHK(3), MPI(4), PFKFB1(10), PFKFB3(7), PFKFB4(6), PFKM(7), PFKP(5), PMM1(3), PMM2(1), SORD(2), TPI1(9)	19170829	158	122	158	38	33	55	30	13	27	0	0.0156	1.000	1.000
372	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5(3), CDK5R1(3), DAB1(34), FYN(8), LRP8(6), RELN(104), VLDLR(5)	11327920	163	122	162	50	17	62	41	14	29	0	0.623	1.000	1.000
373	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	BCAR1(3), CRK(1), CXCL12(3), CXCR4(6), GNAI1(10), GNAQ(5), GNB1(2), GNGT1(6), HRAS(2), MAP2K1(10), MAPK1(2), MAPK3(3), NFKB1(6), PIK3C2G(19), PIK3CA(30), PIK3R1(4), PLCG1(7), PRKCA(10), PTK2(6), PTK2B(14), PXN(1), RAF1(6), RELA(3)	22098127	159	121	146	40	18	71	31	14	25	0	0.103	1.000	1.000
374	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(5), F2(9), F2R(10), F3(3), F5(40), F7(10), FGA(20), FGB(18), FGG(4), PROC(4), PROS1(30), SERPINC1(5), TFPI(4)	13160754	162	121	160	41	13	81	26	11	31	0	0.197	1.000	1.000
375	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(6), F13A1(29), F2(9), F2R(10), FGA(20), FGB(18), FGG(4), PLAT(12), PLG(32), SERPINB2(14), SERPINE1(14)	10835018	168	121	163	47	14	86	33	9	26	0	0.331	1.000	1.000
376	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG3(5), ATG5(3), ATG7(6), BECN1(1), GABARAPL1(1), IFNA1(2), IFNA10(7), IFNA14(4), IFNA16(8), IFNA17(5), IFNA2(5), IFNA21(3), IFNA4(4), IFNA5(5), IFNA6(7), IFNA7(6), IFNA8(7), IFNG(7), PIK3C3(14), PIK3R4(22), PRKAA1(6), PRKAA2(8), ULK1(8), ULK2(9), ULK3(2)	16775574	155	121	153	36	11	76	33	15	19	1	0.124	1.000	1.000
377	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(3), CS(2), DLAT(10), DLD(9), DLST(5), FH(13), IDH2(2), IDH3A(1), IDH3B(4), IDH3G(5), MDH1(3), MDH2(3), OGDH(10), PC(9), PDHA1(5), PDHA2(29), PDHX(4), PDK1(6), PDK2(3), PDK3(5), PDK4(2), PDP2(4), SDHA(8), SDHB(1), SDHD(3), SUCLA2(5), SUCLG1(5), SUCLG2(1)	22875222	160	121	159	51	23	63	23	22	29	0	0.499	1.000	1.000
378	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QA(7), C1QB(11), C1R(4), C1S(4), C2(10), C3(13), C5(6), C6(29), C7(39), C8A(18), C9(20)	14117892	161	120	160	49	16	70	30	19	25	1	0.510	1.000	1.000
379	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ALDH1A3(4), ALDH3A1(5), ALDH3B1(2), ALDH3B2(4), AOC2(6), AOC3(11), DDC(8), EPX(14), ESCO1(10), ESCO2(4), GOT1(3), GOT2(6), HPD(2), LPO(7), MAOA(5), MAOB(3), MPO(15), NAT6(1), PNPLA3(4), PRDX6(5), TAT(9), TPO(33)	27575749	161	120	160	67	31	53	31	20	26	0	0.947	1.000	1.000
380	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	22	ADCY1(26), AKT1(3), BAX(3), BCL2(5), BCL2L1(3), CSF2RB(14), IGF1(4), IGF1R(8), IL3(4), IL3RA(8), KIT(12), KITLG(6), PIK3CA(30), PIK3R1(4), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), YWHAH(1)	17624187	155	119	144	53	14	70	37	12	20	2	0.631	1.000	1.000
381	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(14), ABCC2(11), ABCG2(14), BCHE(35), CES1(8), CYP3A4(4), CYP3A5(5), UGT1A1(12), UGT1A10(9), UGT1A3(6), UGT1A4(4), UGT1A5(8), UGT1A6(9), UGT1A7(7), UGT1A9(7)	18509913	153	119	152	56	12	69	36	16	20	0	0.788	1.000	1.000
382	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSA(2), ARSB(6), ARSD(6), ARSE(5), ASAH1(3), GAL3ST1(7), GALC(9), GBA(7), GLA(9), GLB1(3), LCT(50), NEU1(2), NEU2(7), NEU3(5), NEU4(13), PPAP2A(2), PPAP2B(3), PPAP2C(1), SMPD1(3), SPTLC1(3), SPTLC2(3), UGCG(2)	19347418	151	118	150	44	24	74	28	8	17	0	0.156	1.000	1.000
383	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(6), GALNS(3), GLB1(3), GNS(1), GUSB(5), HEXA(6), HGSNAT(6), HPSE(4), HPSE2(16), HYAL1(3), HYAL2(3), IDS(7), IDUA(1), LCT(50), NAGLU(5), SPAM1(25)	16293964	144	118	143	48	17	67	20	22	18	0	0.524	1.000	1.000
384	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(9), AGPAT2(3), AGPAT3(4), AGPAT4(9), AGPAT6(5), AGPS(6), CHPT1(3), ENPP2(19), ENPP6(8), PAFAH1B1(1), PAFAH1B2(2), PAFAH1B3(2), PAFAH2(3), PLA2G12A(4), PLA2G12B(3), PLA2G1B(2), PLA2G2A(5), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(6), PLA2G4A(21), PLA2G6(3), PLD1(19), PLD2(7), PPAP2A(2), PPAP2B(3), PPAP2C(1)	18600534	156	118	155	38	17	65	29	11	34	0	0.0545	1.000	1.000
385	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA2(2), ADH1A(8), ADH1B(12), ADH4(4), ADH6(8), ADH7(11), ADHFE1(5), AKR1C4(4), AKR1D1(12), ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH9A1(3), BAAT(9), CEL(8), CYP27A1(5), CYP7A1(8), HADHB(10), SOAT2(2), SRD5A1(4)	18668477	161	117	158	45	12	66	37	19	27	0	0.233	1.000	1.000
386	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(4), ABAT(12), ADSL(2), ADSS(6), AGXT(8), AGXT2(13), ASL(4), ASNS(8), ASPA(5), CAD(25), DARS(3), DDO(5), GAD1(7), GAD2(27), GOT1(3), GOT2(6), GPT2(5), NARS(4), PC(9)	20822772	156	116	156	48	22	56	27	18	32	1	0.352	1.000	1.000
387	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(9), ADCY1(26), CCNB1(2), CDC25C(8), GNAI1(10), GNAS(29), GNB1(2), GNGT1(6), HRAS(2), MAPK1(2), MAPK3(3), MYT1(24), PIN1(1), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), RPS6KA1(6), SRC(2)	16355330	156	114	153	50	33	60	27	10	24	2	0.397	1.000	1.000
388	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(7), CREBBP(30), DUSP1(1), EP300(11), IKBKB(9), IL1B(1), MAP2K3(13), MAP2K6(5), MAP3K7(10), MAPK14(4), MYD88(1), NFKB1(6), NFKBIA(4), NR3C1(8), RELA(3), TGFBR1(7), TGFBR2(7), TLR2(10), TNF(2)	23832807	139	114	138	43	12	48	29	12	38	0	0.643	1.000	1.000
389	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ALDH1A3(4), ALDH3A1(5), ALDH3B1(2), ALDH3B2(4), AOC2(6), AOC3(11), DDC(8), EPX(14), GOT1(3), GOT2(6), HPD(2), LPO(7), MAOA(5), MAOB(3), MPO(15), PRDX1(4), PRDX2(2), PRDX5(1), PRDX6(5), TAT(9), TPO(33)	17678811	149	114	148	62	30	49	28	20	22	0	0.855	1.000	1.000
390	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(33), ASAH1(3), CAMP(4), CASP3(5), CERK(4), CREB1(2), CREB5(18), CXCL2(1), DAG1(3), EPHB2(10), FOS(3), GNAQ(5), ITPKA(2), ITPKB(7), JUN(3), MAP2K4(8), MAP2K7(7), MAPK1(2), MAPK10(6), MAPK8(2), MAPK8IP1(4), MAPK8IP2(2), MAPK8IP3(7), MAPK9(8)	22589372	149	114	148	33	21	49	30	9	40	0	0.0495	1.000	1.000
391	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(10), BCL2(5), BID(2), BIRC2(2), BIRC3(4), CASP10(7), CASP3(5), CASP6(3), CASP7(3), CASP8(6), CASP9(6), CFLAR(2), CHUK(7), CYCS(2), DFFA(3), DFFB(4), FADD(2), GAS2(10), LMNA(2), NFKB1(6), NFKBIA(4), RELA(3), RIPK1(11), SPTAN1(21), TNFRSF10B(3), TNFRSF25(2), TNFSF10(3), TNFSF12(1), TRADD(2), TRAF2(5)	26779656	146	113	146	53	8	51	38	16	33	0	0.935	1.000	1.000
392	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(12), BAIAP2(3), CASP1(8), CASP3(5), CASP7(3), CASP8(6), GAPDH(5), INSR(10), ITCH(8), MAGI1(21), MAGI2(33), RERE(12), WWP1(13), WWP2(7)	19234129	146	113	145	42	16	63	21	14	32	0	0.436	1.000	1.000
393	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(9), ACTN1(7), ACTN2(43), CAPN1(2), CAPNS1(1), CAPNS2(2), ITGA1(14), ITGB1(6), ITGB3(13), PTK2(6), PXN(1), SPTAN1(21), SRC(2), TLN1(15)	22874847	142	113	141	56	15	52	38	19	18	0	0.906	1.000	1.000
394	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM1(3), CALM2(1), CHUK(7), EGR2(4), EGR3(1), GNAQ(5), MAP3K1(7), MYC(4), NFATC1(9), NFATC2(15), NFKB1(6), NFKBIA(4), PLCG1(7), PPP3CA(14), PPP3CB(3), PPP3CC(3), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), RELA(3), SYT1(6), VIP(6), VIPR2(3)	22435877	135	113	132	41	19	54	21	14	26	1	0.394	1.000	1.000
395	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(15), ACE2(9), AGT(4), AGTR1(9), AGTR2(6), ANPEP(10), CMA1(8), CPA3(16), CTSA(4), CTSG(12), ENPEP(18), LNPEP(5), MAS1(5), MME(20), NLN(7), REN(6), THOP1(8)	16967000	162	112	161	62	21	71	28	18	23	1	0.765	1.000	1.000
396	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(7), IFNA1(2), IFNB1(7), IKBKB(9), IL1A(4), IL1B(1), IL1R1(2), IL1RAP(4), IL1RN(3), IL6(2), IRAK1(6), IRAK2(6), IRAK3(6), JUN(3), MAP2K3(13), MAP2K6(5), MAP3K1(7), MAP3K7(10), MAPK14(4), MAPK8(2), MYD88(1), NFKB1(6), NFKBIA(4), RELA(3), TGFB1(3), TGFB2(10), TNF(2), TOLLIP(2), TRAF6(6)	23848641	140	112	139	51	6	50	30	17	37	0	0.928	1.000	1.000
397	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	20	CSNK2A1(5), ELK1(3), FOS(3), GRB2(6), HRAS(2), IL6(2), IL6R(8), IL6ST(3), JAK1(11), JAK2(16), JAK3(10), JUN(3), MAP2K1(10), MAPK3(3), PTPN11(9), RAF1(6), SHC1(6), SOS1(17), SRF(1), STAT3(11)	18997736	135	112	130	35	16	37	32	24	26	0	0.271	1.000	1.000
398	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(33), CDH1(6), CREBBP(30), EP300(11), MAP2K1(10), MAP3K7(10), MAPK3(3), SKIL(11), TGFB1(3), TGFB2(10), TGFBR1(7), TGFBR2(7)	20740652	141	112	138	25	14	50	28	14	35	0	0.0268	1.000	1.000
399	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(3), CR1(34), CR2(20), FCGR2B(7), HLA-DRA(3), HLA-DRB1(5), ICAM1(2), ITGAL(26), ITGB2(8), PTPRC(41)	12281228	149	111	144	48	11	63	28	10	37	0	0.776	1.000	1.000
400	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOA(4), ALDOB(8), ALDOC(2), DERA(4), FBP1(2), FBP2(2), G6PD(4), GPI(8), H6PD(5), PFKL(9), PFKM(7), PFKP(5), PGD(2), PGLS(1), PGM1(3), PGM3(3), PRPS1(3), PRPS1L1(3), PRPS2(4), RBKS(1), RPE(3), RPIA(8), TALDO1(1), TKT(3), TKTL1(14), TKTL2(26)	19391436	135	111	135	36	16	44	31	17	27	0	0.149	1.000	1.000
401	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(6), FUCA1(2), FUCA2(3), GLB1(3), HEXA(6), LCT(50), MAN2B1(5), MAN2B2(7), MAN2C1(7), MANBA(11), NEU1(2), NEU2(7), NEU3(5), NEU4(13)	16216807	127	111	126	43	21	60	22	9	15	0	0.461	1.000	1.000
402	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(10), ALOX15(5), ALOX5(10), CYP1A2(3), CYP2C18(7), CYP2C19(13), CYP2C8(2), CYP2C9(8), CYP2E1(7), CYP2J2(1), CYP3A4(4), CYP3A43(3), CYP3A5(5), CYP3A7(7), HSD3B7(7), PLA2G12A(4), PLA2G12B(3), PLA2G1B(2), PLA2G2A(5), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(6), PLA2G4A(21), PLA2G6(3), RDH11(4), RDH12(3), RDH13(1), RDH14(2)	19242354	152	111	151	62	17	66	37	15	17	0	0.905	1.000	1.000
403	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(1), B4GALNT1(9), GLB1(3), HEXA(6), LCT(50), SLC33A1(4), ST3GAL1(4), ST3GAL2(4), ST3GAL5(3), ST6GALNAC3(15), ST6GALNAC4(1), ST6GALNAC5(11), ST6GALNAC6(2), ST8SIA1(6), ST8SIA5(12)	13265083	131	111	130	49	24	47	27	12	21	0	0.684	1.000	1.000
404	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(4), CARS(4), DARS(3), EPRS(27), FARS2(5), GARS(3), HARS(5), IARS(9), KARS(8), LARS(14), LARS2(2), MARS(5), MARS2(13), NARS(4), QARS(6), RARS(6), SARS(5), TARS(14), WARS(6), WARS2(7), YARS(3)	25898121	153	110	153	38	12	59	35	18	29	0	0.232	1.000	1.000
405	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	B2M(9), HLA-A(8), ITGB1(6), KLRC1(5), KLRC2(2), KLRC3(5), KLRC4(2), KLRD1(2), LAT(4), MAP2K1(10), MAPK3(3), PAK1(9), PIK3CA(30), PIK3R1(4), PTK2B(14), PTPN6(6), SYK(5), VAV1(8)	14993870	132	109	117	29	21	48	18	16	29	0	0.0483	1.000	1.000
406	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CCNH(3), CDK7(3), ERCC3(5), GTF2A2(1), GTF2B(1), GTF2E1(8), GTF2E2(2), GTF2H1(4), GTF2H4(1), ILK(1), MNAT1(2), POLR1A(13), POLR1B(11), POLR2A(11), POLR2B(10), POLR2C(4), POLR2E(2), POLR2F(1), POLR2G(1), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(2), POLR3B(20), POLR3D(3), POLR3E(6), POLR3H(1), POLR3K(2), TAF5(5), TAF6(3), TAF7(3), TAF9(3), TBP(1)	28239498	137	108	137	47	22	40	39	14	21	1	0.865	1.000	1.000
407	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(8), DYRK1B(5), GLI2(28), GLI3(39), GSK3B(4), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), SHH(2), SMO(17), SUFU(2)	13336116	129	108	127	38	34	45	25	7	17	1	0.222	1.000	1.000
408	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	AANAT(1), ACHE(4), CHAT(22), COMT(1), DBH(12), DDC(8), GAD1(7), GAD2(27), HDC(16), MAOA(5), PAH(11), PNMT(1), SLC18A3(19), TH(7), TPH1(8)	11438375	149	106	148	53	23	60	25	10	31	0	0.592	1.000	1.000
409	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(5), ELK1(3), FOS(3), GRB2(6), HRAS(2), IL2(7), IL2RA(6), IL2RB(7), IL2RG(5), JAK1(11), JAK3(10), JUN(3), LCK(9), MAP2K1(10), MAPK3(3), MAPK8(2), RAF1(6), SHC1(6), SOS1(17), STAT5A(3), STAT5B(8), SYK(5)	18686649	137	106	132	38	16	46	29	20	26	0	0.283	1.000	1.000
410	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	CSNK2A1(5), ELK1(3), FOS(3), GRB2(6), HRAS(2), JUN(3), KLK2(10), MAP2K1(10), MAPK3(3), MAPK8(2), NGFR(5), PIK3CA(30), PIK3R1(4), PLCG1(7), RAF1(6), SHC1(6), SOS1(17)	15412157	122	106	107	27	12	50	29	14	17	0	0.0924	1.000	1.000
411	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(6), GALNT10(6), GALNT2(11), GALNT3(12), GALNT4(4), GALNT6(5), GALNT7(9), GALNT8(19), GCNT1(8), ST3GAL1(4), ST3GAL2(4), ST3GAL4(4), WBSCR17(33)	11655898	125	106	124	62	15	50	31	15	14	0	0.998	1.000	1.000
412	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	ADAM17(8), APC(33), AXIN1(7), BTRC(12), CTNNB1(20), DLL1(5), DVL1(5), FZD1(6), GSK3B(4), NOTCH1(26), PSEN1(6), WNT1(6)	16636417	138	106	130	26	28	48	23	13	26	0	0.00891	1.000	1.000
413	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	CALM1(3), CALM2(1), CDKN1A(2), GNAQ(5), MARCKS(2), NFATC1(9), NFATC2(15), NFATC3(15), NFATC4(11), PLCG1(7), PPP3CA(14), PPP3CB(3), PPP3CC(3), PRKCA(10), SP1(6), SP3(6), SYT1(6)	16789317	118	105	115	38	19	50	19	8	22	0	0.462	1.000	1.000
414	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(22), BST1(3), CD38(4), ENPP1(14), ENPP3(19), NADK(3), NADSYN1(2), NMNAT1(3), NMNAT2(8), NMNAT3(1), NNMT(7), NNT(11), NT5C1A(12), NT5C1B(11), NT5C2(3), NT5E(5), NT5M(3), NUDT12(7), QPRT(2)	17307368	140	105	138	41	15	50	21	21	33	0	0.457	1.000	1.000
415	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCL4(2), CCR1(3), CCR2(6), CCR3(4), CCR4(3), CCR5(4), CD28(4), CD4(8), CXCR3(3), CXCR4(6), IFNG(7), IFNGR1(7), IFNGR2(4), IL12A(2), IL12B(3), IL12RB1(5), IL12RB2(15), IL18R1(12), IL2(7), IL4(1), IL4R(10), IL5(2), TGFB1(3), TGFB2(10)	16147480	131	105	131	33	14	53	21	13	29	1	0.0856	1.000	1.000
416	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(17), APOA1(3), APOA4(12), APOC1(2), APOC2(2), APOC3(2), APOE(1), CETP(8), CYP7A1(8), DGAT1(1), HMGCR(5), LCAT(6), LDLR(9), LIPC(9), LPL(8), LRP1(36), SCARB1(4), SOAT1(8)	21987629	141	105	137	53	21	50	25	19	25	1	0.832	1.000	1.000
417	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(13), C5(6), C6(29), C7(39), C8A(18), C9(20)	10140162	125	103	124	37	12	55	26	11	20	1	0.578	1.000	1.000
418	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(7), DCXR(1), GUSB(5), RPE(3), UCHL1(4), UCHL3(1), UGDH(6), UGT1A1(12), UGT1A10(9), UGT1A3(6), UGT1A4(4), UGT1A5(8), UGT1A6(9), UGT1A7(7), UGT1A9(7), UGT2B15(14), UGT2B4(28)	14237894	131	103	130	40	6	59	35	13	18	0	0.514	1.000	1.000
419	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	AKT1(3), AKT2(7), AKT3(7), BPNT1(7), GRB2(6), ILK(1), MAPK1(2), MAPK3(3), PDK1(6), PIK3CA(30), PIK3CD(4), PTEN(11), PTK2B(14), RBL2(5), SHC1(6), SOS1(17)	16368664	129	103	116	35	13	57	32	12	15	0	0.347	1.000	1.000
420	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(1), CSF1R(18), DDX20(4), E2F1(3), E2F4(5), ETS1(8), ETS2(6), ETV3(2), FOS(3), HDAC2(8), HDAC5(5), HRAS(2), JUN(3), NCOR2(30), RBL1(7), RBL2(5), SIN3A(12), SIN3B(2)	20506999	124	102	124	43	15	35	33	17	24	0	0.770	1.000	1.000
421	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH3B1(2), ALDH3B2(4), ALDH9A1(3), AOC2(6), AOC3(11), ASPA(5), CNDP1(10), DDC(8), HAL(5), HARS(5), HDC(16), MAOA(5), MAOB(3), PRPS1(3), PRPS2(4)	19703306	136	102	136	40	25	46	24	18	23	0	0.194	1.000	1.000
422	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(24), AP2A1(4), AP2M1(5), BIN1(4), CALM1(3), CALM2(1), DNM1(11), EPN1(11), EPS15(7), PICALM(6), PPP3CA(14), PPP3CB(3), PPP3CC(3), SYNJ1(14), SYNJ2(9), SYT1(6)	17322327	125	102	121	39	15	46	25	11	28	0	0.694	1.000	1.000
423	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(5), GTF2A1(3), GTF2B(1), GTF2E1(8), GTF2F1(4), HDAC3(3), NCOA1(18), NCOA2(22), NCOA3(14), NCOR2(30), POLR2A(11), RARA(7), RXRA(1), TBP(1)	19823020	128	102	128	39	17	43	33	19	16	0	0.510	1.000	1.000
424	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(3), BCAT2(2), COASY(6), DPYD(24), DPYS(22), ENPP1(14), ENPP3(19), ILVBL(3), PANK1(4), PANK2(5), PANK3(5), PANK4(5), PPCDC(2), PPCS(1), UPB1(2), VNN1(10)	13820415	127	101	124	34	14	59	18	15	20	1	0.220	1.000	1.000
425	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(6), FUCA1(2), FUCA2(3), GLB1(3), HEXA(6), LCT(50), MAN2C1(7), MANBA(11), NEU1(2), NEU2(7), NEU3(5), NEU4(13)	13180834	115	101	114	36	18	57	20	7	13	0	0.333	1.000	1.000
426	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(2), ALDH18A1(3), ARG1(2), ASL(4), CKB(1), CKM(4), CKMT1A(1), CKMT1B(1), CKMT2(2), CPS1(71), GATM(8), GLUD1(4), NAGS(1), OAT(3), ODC1(1), OTC(10), PYCR1(1), SMS(3)	13907447	122	101	121	44	12	47	22	18	22	1	0.811	1.000	1.000
427	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(1), CARM1(4), CBS(1), CTH(2), GGT1(1), LCMT1(5), LCMT2(7), MARS(5), MARS2(13), MAT1A(7), MAT2B(3), METTL2B(5), METTL6(1), PAPSS1(5), PAPSS2(10), PRMT2(2), PRMT3(8), PRMT5(7), PRMT6(7), PRMT7(4), PRMT8(13), SCLY(4), SEPHS1(4), SEPHS2(2), WBSCR22(3)	20010499	124	100	122	50	22	40	27	13	22	0	0.884	1.000	1.000
428	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	AKT1(3), GRB2(6), HRAS(2), IGF1R(8), IRS1(20), MAP2K1(10), MAPK1(2), MAPK3(3), PIK3CA(30), PIK3R1(4), RAF1(6), SHC1(6), SOS1(17), YWHAH(1)	15299323	118	100	102	28	13	51	26	13	15	0	0.130	1.000	1.000
429	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	AKT1(3), AKT2(7), AKT3(7), CDKN1A(2), ELK1(3), GRB2(6), HRAS(2), MAP2K1(10), MAP2K2(1), NGFR(5), NTRK1(14), PIK3CA(30), PIK3CD(4), SHC1(6), SOS1(17)	12865991	117	100	102	28	11	53	30	12	10	1	0.112	1.000	1.000
430	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(45), ABCB11(28), ABCB4(19), ABCC1(14), ABCC3(13), GSTP1(2)	11611517	121	99	120	35	11	48	27	11	24	0	0.309	1.000	1.000
431	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	ADRB2(4), AKT1(3), ANXA1(1), CALM1(3), CALM2(1), GNAS(29), GNB1(2), GNGT1(6), NFKB1(6), NOS3(12), NPPA(3), NR3C1(8), PIK3CA(30), PIK3R1(4), RELA(3), SYT1(6)	14240325	121	98	107	28	17	52	24	8	20	0	0.117	1.000	1.000
432	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	36	ANPEP(10), G6PD(4), GCLC(13), GGT1(1), GPX3(2), GPX5(7), GPX6(7), GPX7(4), GSR(5), GSS(4), GSTA1(7), GSTA2(7), GSTA3(2), GSTA4(2), GSTA5(6), GSTK1(1), GSTM1(1), GSTM2(4), GSTM3(2), GSTM4(1), GSTM5(3), GSTO2(3), GSTP1(2), GSTT1(1), GSTZ1(2), IDH1(6), IDH2(2), MGST1(1), MGST2(2), MGST3(2), OPLAH(10), TXNDC12(2)	17465013	126	98	127	21	15	49	19	10	33	0	0.000431	1.000	1.000
433	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	AKT1(3), BCL2L1(3), CASP9(6), CDC42(1), CHUK(7), ELK1(3), H2AFX(3), HRAS(2), MAP2K1(10), MAPK3(3), NFKB1(6), PIK3CA(30), PIK3R1(4), RAF1(6), RALA(5), RALBP1(3), RALGDS(5), RELA(3), RHOA(4)	15259168	107	98	93	26	7	47	22	13	18	0	0.163	1.000	1.000
434	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	ATF1(1), CASP2(13), CHUK(7), CRADD(3), IKBKB(9), JUN(3), LTA(3), MAP2K3(13), MAP2K4(8), MAP2K6(5), MAP3K1(7), MAP4K2(4), MAPK14(4), MAPK8(2), NFKB1(6), NFKBIA(4), RELA(3), RIPK1(11), TANK(3), TNF(2), TRADD(2), TRAF2(5)	19246618	118	98	118	41	9	43	26	10	30	0	0.777	1.000	1.000
435	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(1), AMD1(2), BHMT(7), CBS(1), CTH(2), DNMT1(8), DNMT3A(25), DNMT3B(10), MARS(5), MARS2(13), MAT1A(7), MAT2B(3), MTAP(2), MTFMT(1), MTR(22), SRM(2), TAT(9)	16605481	120	97	120	40	18	44	22	11	25	0	0.623	1.000	1.000
436	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(10), CALM1(3), CALM2(1), CAPN2(5), CAPNS1(1), CAPNS2(2), EP300(11), HDAC1(4), HDAC2(8), MEF2D(4), NFATC1(9), NFATC2(15), PPP3CA(14), PPP3CB(3), PPP3CC(3), PRKCA(10), SYT1(6)	19557403	109	97	106	40	21	40	13	9	26	0	0.713	1.000	1.000
437	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ACTR2(4), ACTR3(2), ARPC1A(3), ARPC1B(4), ARPC2(3), ARPC3(2), CDC42(1), PAK1(9), PDGFRA(41), PIK3CA(30), PIK3R1(4), WASL(7)	10832772	110	96	98	32	8	42	24	10	25	1	0.670	1.000	1.000
438	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(5), ACO2(3), CS(2), DLD(9), DLST(5), FH(13), IDH1(6), IDH2(2), IDH3A(1), IDH3B(4), IDH3G(5), MDH1(3), MDH2(3), PC(9), PCK1(21), SDHA(8), SDHB(1), SUCLA2(5), SUCLG1(5), SUCLG2(1)	16611796	111	96	110	46	18	38	12	18	25	0	0.898	1.000	1.000
439	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	16	B3GAT1(5), B3GAT2(10), CHPF(10), CHST11(2), CHST12(6), CHST13(3), CHST14(2), CHST3(1), CHST7(2), CHSY1(5), DSE(19), UST(5), XYLT1(44), XYLT2(3)	11111541	117	96	115	48	29	31	28	12	17	0	0.774	1.000	1.000
440	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(7), ICAM1(2), ITGA4(38), ITGAL(26), ITGB1(6), ITGB2(8), SELE(17), SELL(9)	9773661	113	96	111	31	6	54	27	9	17	0	0.440	1.000	1.000
441	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(26), CREM(3), FHL5(15), FSHB(4), FSHR(37), GNAS(29), XPO1(12)	7620498	126	95	122	42	24	54	23	10	14	1	0.784	1.000	1.000
442	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(5), ELK1(3), EPO(6), EPOR(2), FOS(3), GRB2(6), HRAS(2), JAK2(16), JUN(3), MAP2K1(10), MAPK3(3), MAPK8(2), PLCG1(7), PTPN6(6), RAF1(6), SHC1(6), SOS1(17), STAT5A(3), STAT5B(8)	17270267	114	95	109	24	19	34	26	15	20	0	0.0459	1.000	1.000
443	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(4), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH7A1(3), ALDH9A1(3), CYP2C19(13), CYP2C9(8), DHRS2(6), DHRS3(2), DHRS7(3), DHRSX(3), ECHS1(4), EHHADH(13), ESCO1(10), ESCO2(4), HADHA(3), NAT6(1), PNPLA3(4), YOD1(1)	24862284	115	95	114	35	13	42	28	13	19	0	0.567	1.000	1.000
444	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	MRPL13(3), MRPS7(3), RPL10A(2), RPL10L(16), RPL11(2), RPL13A(2), RPL14(2), RPL19(2), RPL21(1), RPL22L1(3), RPL23A(2), RPL24(1), RPL26(3), RPL27A(2), RPL28(2), RPL29(1), RPL3(3), RPL30(2), RPL31(1), RPL34(1), RPL36A(2), RPL36AL(1), RPL37(2), RPL3L(8), RPL41(1), RPL6(4), RPL7(2), RPL8(3), RPL9(1), RPS10(3), RPS11(1), RPS13(1), RPS16(4), RPS18(2), RPS2(2), RPS20(1), RPS25(2), RPS26(1), RPS27(1), RPS28(1), RPS29(1), RPS3(5), RPS3A(2), RPS4Y1(1), RPS5(2), RPS6(3), RPS7(1), RPSA(1)	17937359	113	93	109	32	19	36	20	12	26	0	0.367	1.000	1.000
445	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(3), COASY(6), DPYD(24), DPYS(22), ENPP1(14), ENPP3(19), PANK1(4), PANK2(5), PANK3(5), PANK4(5), PPCS(1), UPB1(2)	11120123	110	93	107	31	10	51	16	13	19	1	0.410	1.000	1.000
446	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(14), LPO(7), MPO(15), PRDX1(4), PRDX2(2), PRDX5(1), PRDX6(5), TPO(33), TYR(29)	7742906	110	93	109	43	18	40	24	12	16	0	0.774	1.000	1.000
447	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	AKT1(3), CREB1(2), GRB2(6), HRAS(2), MAPK1(2), MAPK3(3), MAPK7(7), MEF2A(2), MEF2B(2), MEF2C(6), MEF2D(4), NTRK1(14), PIK3CA(30), PIK3R1(4), PLCG1(7), RPS6KA1(6), SHC1(6)	15227173	106	92	94	26	16	44	22	9	14	1	0.110	1.000	1.000
448	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(14), FOS(3), GRB2(6), HRAS(2), IL3(4), IL3RA(8), JAK2(16), MAP2K1(10), MAPK3(3), PTPN6(6), RAF1(6), SHC1(6), SOS1(17), STAT5A(3), STAT5B(8)	14173710	112	92	107	27	17	38	28	15	14	0	0.103	1.000	1.000
449	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	AKT1(3), GRB2(6), HRAS(2), KLK2(10), NTRK1(14), PIK3CA(30), PIK3R1(4), PLCG1(7), PRKCA(10), SHC1(6), SOS1(17)	12562243	109	92	95	31	13	47	26	10	12	1	0.405	1.000	1.000
450	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(3), AP2A1(4), AP2M1(5), ARF1(1), BTK(25), EEA1(5), GSK3A(1), GSK3B(4), LYN(6), PDPK1(3), PFKL(9), PFKM(7), PFKP(5), PLCG1(7), PRKCE(5), PRKCZ(4), RAB5A(2), RPS6KB1(3), VAV2(8)	19805791	107	91	106	27	12	31	28	12	23	1	0.225	1.000	1.000
451	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BIRC2(2), BIRC3(4), CASP3(5), CASP8(6), CFLAR(2), FADD(2), JUN(3), MAP2K4(8), MAP3K3(10), MAP3K7(10), NFKB1(6), NFKB2(5), NFKBIA(4), NFKBIB(3), NFKBIE(2), NFKBIL1(1), NR2C2(2), RALBP1(3), RIPK1(11), TNF(2), TNFAIP3(6), TNFRSF1B(2), TRADD(2), TRAF2(5)	21702517	106	91	105	33	9	40	24	7	26	0	0.621	1.000	1.000
452	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(6), GPLD1(10), PGAP1(8), PIGA(6), PIGB(5), PIGC(1), PIGG(13), PIGK(3), PIGL(4), PIGM(2), PIGN(10), PIGO(11), PIGP(2), PIGQ(6), PIGS(4), PIGT(7), PIGU(1), PIGV(4), PIGW(2), PIGX(4), PIGZ(3)	19033646	112	89	111	49	13	38	27	15	19	0	0.961	1.000	1.000
453	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(26), ADRB2(4), GNAS(29), PLCE1(28), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), RAP2B(2)	11785893	113	89	109	38	27	44	17	8	14	3	0.570	1.000	1.000
454	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(4), AKR1D1(12), CYP11A1(5), CYP11B1(27), CYP11B2(24), CYP17A1(6), CYP21A2(2), HSD11B1(9), HSD3B1(6), HSD3B2(15)	7379109	110	88	109	40	12	42	26	13	16	1	0.596	1.000	1.000
455	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(26), GNAS(29), GNB1(2), GNGT1(6), PPP2CA(1), PRKAA1(6), PRKAA2(8), PRKAB1(3), PRKACB(9), PRKACG(4), PRKAG1(1), PRKAG2(5), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2)	12237886	111	88	108	38	26	39	24	7	13	2	0.751	1.000	1.000
456	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(4), AKR1D1(12), CYP11A1(5), CYP11B1(27), CYP11B2(24), CYP17A1(6), CYP21A2(2), HSD11B1(9), HSD3B1(6), HSD3B2(15)	7379109	110	88	109	40	12	42	26	13	16	1	0.596	1.000	1.000
457	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP1(4), ACP2(4), ACP5(4), ACP6(3), ACPP(8), ACPT(7), ALPI(9), ALPL(3), ALPP(13), ALPPL2(4), CMBL(1), CYP3A4(4), CYP3A43(3), CYP3A5(5), CYP3A7(7), DHRS2(6), DHRS3(2), DHRS7(3), DHRSX(3), PON1(3), PON2(2), PON3(5)	14444794	103	88	103	43	5	40	22	15	21	0	0.919	1.000	1.000
458	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	AKT1(3), BCAR1(3), CDKN1B(5), GRB2(6), ILK(1), ITGB1(6), MAPK1(2), MAPK3(3), PDK2(3), PDPK1(3), PIK3CA(30), PIK3R1(4), PTEN(11), PTK2(6), SHC1(6), SOS1(17)	15476399	109	88	96	28	8	45	25	14	17	0	0.348	1.000	1.000
459	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(13), POLR1B(11), POLR1D(2), POLR2A(11), POLR2B(10), POLR2C(4), POLR2D(3), POLR2E(2), POLR2F(1), POLR2G(1), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(2), POLR3A(17), POLR3B(20), POLR3G(2), POLR3H(1), POLR3K(2), ZNRD1(1)	18917469	107	87	107	34	16	35	31	9	16	0	0.696	1.000	1.000
460	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(4), ALG5(1), B4GALT1(1), B4GALT2(4), B4GALT3(2), B4GALT5(6), DDOST(1), DPAGT1(5), DPM1(5), FUT8(7), MAN1A1(3), MAN1B1(4), MGAT1(7), MGAT2(5), MGAT3(15), MGAT4A(3), MGAT4B(7), MGAT5(13), RPN1(3), RPN2(4), ST6GAL1(4)	15889813	104	87	104	30	19	44	14	11	16	0	0.214	1.000	1.000
461	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM1(3), CALM2(1), CAMK1(1), CAMK1G(2), CAMK2A(3), CAMK2B(16), CAMK2D(7), CAMK4(16), HDAC5(5), MEF2A(2), MEF2B(2), MEF2C(6), MEF2D(4), PPARA(4), PPP3CA(14), PPP3CB(3), PPP3CC(3), SLC2A4(4), SYT1(6), YWHAH(1)	16155923	103	87	100	22	10	38	16	12	27	0	0.0702	1.000	1.000
462	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(6), CD28(4), CD3D(2), CD3E(2), CD4(8), ICAM1(2), ITGAL(26), ITGB2(8), PTPRC(41), THY1(6)	9079402	105	87	105	36	11	39	24	5	26	0	0.679	1.000	1.000
463	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	AKT1(3), CASP9(6), CHUK(7), GH1(7), GHR(19), NFKB1(6), NFKBIA(4), PDPK1(3), PIK3CA(30), PIK3R1(4), PPP2CA(1), RELA(3), YWHAH(1)	11357153	94	86	83	28	2	46	18	9	19	0	0.594	1.000	1.000
464	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(14), AMT(1), ATIC(7), DHFR(2), FTCD(8), GART(9), MTFMT(1), MTHFD1(6), MTHFD1L(12), MTHFD2(2), MTHFR(7), MTHFS(1), MTR(22), SHMT1(2), SHMT2(2), TYMS(3)	15191954	99	86	98	25	14	40	12	7	26	0	0.150	1.000	1.000
465	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(6), IL22(4), IL22RA1(7), IL22RA2(6), JAK1(11), JAK2(16), JAK3(10), STAT1(7), STAT3(11), STAT5A(3), STAT5B(8), TYK2(5)	14605481	94	86	94	28	8	24	21	18	23	0	0.584	1.000	1.000
466	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	CISH(1), IL6(2), IL6R(8), JAK1(11), JAK2(16), JAK3(10), PIAS3(7), PTPRU(19), REG1A(20), SRC(2), STAT3(11)	12181194	107	86	105	32	12	36	21	14	24	0	0.368	1.000	1.000
467	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(10), CHUK(7), IFNG(7), IKBKB(9), IL2(7), IL4(1), JUN(3), MAP3K1(7), MAP3K5(14), MAP4K5(2), MAPK14(4), MAPK8(2), NFKB1(6), NFKBIA(4), RELA(3), TNFRSF9(7), TNFSF9(3), TRAF2(5)	15554068	101	85	101	29	7	32	18	10	33	1	0.652	1.000	1.000
468	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(32), MAP2(49), PPP1CA(2), PPP2CA(1), PRKACB(9), PRKACG(4), PRKAG1(1), PRKAR2A(3), PRKAR2B(2), PRKCE(5)	14641764	108	85	107	27	9	42	27	14	14	2	0.525	1.000	1.000
469	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(10), GCK(6), GFPT1(8), GNE(2), GNPDA1(2), GNPDA2(2), HEXA(6), HK1(12), HK2(11), HK3(22), PGM3(3), RENBP(7), UAP1(7)	13601954	98	85	98	32	23	36	13	11	15	0	0.469	1.000	1.000
470	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(10), ARHGDIB(2), BIRC2(2), BIRC3(4), CASP1(8), CASP10(7), CASP2(13), CASP3(5), CASP4(6), CASP6(3), CASP7(3), CASP8(6), CASP9(6), CYCS(2), DFFA(3), DFFB(4), GZMB(6), LMNA(2), LMNB1(5), LMNB2(5), PRF1(8)	15507295	110	85	109	32	4	45	24	13	24	0	0.585	1.000	1.000
471	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	CNR1(15), CNR2(3), DNMT1(8), MTNR1A(15), MTNR1B(13), PTAFR(5), PTGDR(8), PTGER2(4), PTGER4(7), PTGFR(12), PTGIR(6), TBXA2R(1)	8843339	97	85	96	38	20	31	19	13	13	1	0.599	1.000	1.000
472	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	AKT1(3), CHRNB1(5), CHRNG(7), MUSK(12), PIK3CA(30), PIK3R1(4), PTK2(6), PTK2B(14), RAPSN(3), SRC(2), TERT(7), YWHAH(1)	13086207	94	84	83	25	12	39	19	10	14	0	0.144	1.000	1.000
473	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOA(4), ALDOB(8), ALDOC(2), FBP1(2), FBP2(2), GOT1(3), GOT2(6), GPT2(5), MDH1(3), MDH2(3), ME1(3), ME2(9), ME3(8), PGK1(4), PKLR(16), RPE(3), RPIA(8), TKT(3), TPI1(9)	14454299	101	84	100	20	14	32	21	14	20	0	0.0258	1.000	1.000
474	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	AKT1(3), EIF2S2(3), EIF2S3(3), EIF4E(4), GSK3B(4), IGF1(4), IGF1R(8), INPPL1(11), PDK2(3), PDPK1(3), PIK3CA(30), PIK3R1(4), PPP2CA(1), PTEN(11), RPS6(3), RPS6KB1(3)	15858521	98	84	87	22	8	47	19	9	15	0	0.116	1.000	1.000
475	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(1), BHMT(7), CBS(1), CTH(2), DNMT1(8), DNMT3A(25), DNMT3B(10), MARS(5), MARS2(13), MAT1A(7), MAT2B(3), MTR(22)	13939418	104	84	104	33	13	37	20	11	23	0	0.506	1.000	1.000
476	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(9), ACTR2(4), ACTR3(2), ARPC1A(3), ARPC1B(4), ARPC2(3), ARPC3(2), NCK1(5), NCKAP1(11), NTRK1(14), PIR(4), PSMA7(5), WASF1(10), WASF2(3), WASF3(13), WASL(7)	12318169	99	83	97	35	13	30	22	10	23	1	0.848	1.000	1.000
477	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BAX(3), BCL2(5), CASP8(6), CYCS(2), FADD(2), MAP2K1(10), MAP2K4(8), MAP3K1(7), MAPK1(2), MAPK3(3), MAPK8(2), NFKB1(6), NSMAF(10), RAF1(6), RELA(3), RIPK1(11), SMPD1(3), TRADD(2), TRAF2(5)	16473660	96	83	93	32	11	33	27	11	14	0	0.654	1.000	1.000
478	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CCR5(4), CD3D(2), CD3E(2), CXCR3(3), ETV5(6), IFNG(7), IL12A(2), IL12B(3), IL12RB1(5), IL12RB2(15), IL18R1(12), JAK2(16), JUN(3), MAP2K6(5), MAPK14(4), MAPK8(2), STAT4(11), TYK2(5)	14944366	107	83	107	25	10	35	21	12	28	1	0.163	1.000	1.000
479	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(2), ATP6V0C(4), CAT(3), EPX(14), LPO(7), MPO(15), PRDX1(4), PRDX2(2), PRDX5(1), PRDX6(5), SHMT1(2), SHMT2(2), TPO(33)	9442451	94	83	92	38	18	32	18	12	14	0	0.781	1.000	1.000
480	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(14), AMT(1), ATIC(7), ATP6V0C(4), DHFR(2), GART(9), MTHFD1(6), MTHFD1L(12), MTHFD2(2), MTHFR(7), MTHFS(1), MTR(22), SHMT1(2), SHMT2(2), TYMS(3)	14411684	94	83	92	22	14	36	11	8	25	0	0.0868	1.000	1.000
481	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(4), POLD1(7), POLD2(3), POLE(31), POLG(12), POLL(7), POLQ(36)	13406889	100	82	99	30	14	39	25	10	12	0	0.487	1.000	1.000
482	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(22), CD38(4), ENPP1(14), ENPP3(19), NADSYN1(2), NMNAT1(3), NMNAT2(8), NNMT(7), NNT(11), NT5E(5), NT5M(3), QPRT(2)	11710641	100	82	98	32	11	39	11	18	21	0	0.605	1.000	1.000
483	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(6), CD28(4), CD3D(2), CD3E(2), CD8A(4), ICAM1(2), ITGAL(26), ITGB2(8), PTPRC(41), THY1(6)	8651043	101	82	101	38	12	35	25	4	25	0	0.828	1.000	1.000
484	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD28(4), CD86(11), HLA-DRA(3), HLA-DRB1(5), IFNG(7), IFNGR1(7), IFNGR2(4), IL12A(2), IL12B(3), IL12RB1(5), IL12RB2(15), IL18R1(12), IL2(7), IL2RA(6), IL4(1), IL4R(10)	10203446	102	82	98	30	10	38	15	7	31	1	0.557	1.000	1.000
485	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(26), ADRB2(4), CFTR(11), GNAS(29), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), SLC9A3R1(1)	10408581	95	81	92	33	24	37	15	6	10	3	0.691	1.000	1.000
486	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(30), EP300(11), LPL(8), NCOA1(18), NCOA2(22), PPARG(8), RXRA(1)	14903897	98	81	98	19	14	34	21	11	18	0	0.0377	1.000	1.000
487	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(12), KHK(3), LCT(50), MPI(4), PGM1(3), PYGL(6), PYGM(9), TPI1(9), TREH(1)	10753455	97	80	96	27	15	44	23	5	10	0	0.133	1.000	1.000
488	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(7), ICAM1(2), ITGAL(26), ITGAM(24), ITGB2(8), SELE(17), SELL(9)	8386806	93	80	91	35	8	45	24	4	12	0	0.741	1.000	1.000
489	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(6), GALNS(3), GLB1(3), GNS(1), GUSB(5), HEXA(6), IDS(7), IDUA(1), LCT(50), NAGLU(5)	11432703	87	78	86	30	13	43	10	9	12	0	0.536	1.000	1.000
490	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(4), CREB1(2), CREBBP(30), EP300(11), NCOA3(14), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), RARA(7), RXRA(1)	16607315	93	77	93	21	14	37	20	8	13	1	0.114	1.000	1.000
491	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(3), BCAT2(2), IARS(9), IARS2(15), ILVBL(3), LARS(14), LARS2(2), PDHA1(5), PDHA2(29), VARS(10), VARS2(2)	14999013	94	77	93	26	12	35	15	11	21	0	0.334	1.000	1.000
492	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(4), ALDOB(8), ALDOC(2), FBP1(2), FBP2(2), G6PD(4), GPI(8), H6PD(5), PFKM(7), PFKP(5), PGD(2), PGLS(1), PGM1(3), PGM3(3), PRPS1(3), PRPS1L1(3), PRPS2(4), RBKS(1), RPE(3), RPIA(8), TAL1(7), TALDO1(1), TKT(3)	16397956	89	77	89	26	12	27	19	13	18	0	0.327	1.000	1.000
493	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	30	ANPEP(10), G6PD(4), GCLC(13), GGT1(1), GPX3(2), GPX5(7), GSS(4), GSTA1(7), GSTA2(7), GSTA3(2), GSTA4(2), GSTM1(1), GSTM2(4), GSTM3(2), GSTM4(1), GSTM5(3), GSTO2(3), GSTP1(2), GSTT1(1), GSTZ1(2), IDH1(6), IDH2(2), MGST1(1), MGST2(2), MGST3(2), PGD(2)	14510190	93	76	93	16	11	36	12	7	27	0	0.00372	1.000	1.000
494	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(7), ACAD9(5), ADH1A(8), ADH1B(12), ADH4(4), ADH5(2), ADH6(8), ADH7(11), ADHFE1(5), DHRS2(6), DHRS3(2), DHRS7(3), DHRSX(3), ESCO1(10), ESCO2(4), NAT6(1), PNPLA3(4)	20146303	95	76	92	30	6	39	20	8	22	0	0.648	1.000	1.000
495	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CHUK(7), CREBBP(30), EP300(11), FADD(2), HDAC3(3), IKBKB(9), NFKB1(6), NFKBIA(4), RELA(3), RIPK1(11), TNF(2), TNFRSF1B(2), TRADD(2), TRAF6(6)	17978878	98	76	98	32	11	30	23	11	23	0	0.666	1.000	1.000
496	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3D(2), CD3E(2), CD4(8), FYN(8), HLA-DRA(3), HLA-DRB1(5), LCK(9), PTPRC(41), ZAP70(9)	7299922	87	76	83	27	10	28	15	5	29	0	0.690	1.000	1.000
497	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(2), CAT(3), EPX(14), LPO(7), MPO(15), MTHFR(7), PRDX6(5), SHMT1(2), SHMT2(2), TPO(33)	9328337	90	75	89	38	19	32	16	9	14	0	0.832	1.000	1.000
498	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(20), CPT1A(11), LEP(4), LEPR(26), PRKAA1(6), PRKAA2(8), PRKAB1(3), PRKAG1(1), PRKAG2(5)	11717314	84	75	83	28	9	29	23	6	17	0	0.796	1.000	1.000
499	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(12), IL13(2), IL4(1), IL5(2), JUNB(1), MAF(3), MAP2K3(13), MAPK14(4), NFATC1(9), NFATC2(15), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2)	9567274	86	74	85	35	15	36	16	4	14	1	0.776	1.000	1.000
500	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	BET1(2), BNIP1(3), GOSR1(2), GOSR2(3), SNAP23(3), SNAP25(5), SNAP29(1), STX11(3), STX12(3), STX16(5), STX17(4), STX18(3), STX19(3), STX2(8), STX3(6), STX4(1), STX5(3), STX6(3), STX7(3), STX8(2), TSNARE1(8), USE1(2), VAMP3(1), VAMP4(2), VAMP5(1), VAMP7(4), VAMP8(1), VTI1A(2), VTI1B(1), YKT6(1)	13367893	89	74	89	26	7	28	20	12	22	0	0.501	1.000	1.000
501	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(4), CYP51A1(5), DHCR24(3), DHCR7(6), EBP(3), FDFT1(4), FDPS(5), GGCX(7), GGPS1(2), HMGCR(5), HSD17B7(3), IDI1(2), IDI2(1), LSS(10), MVD(2), MVK(4), NSDHL(7), PMVK(2), SQLE(4), TM7SF2(6)	15429563	85	73	83	26	13	24	21	11	16	0	0.459	1.000	1.000
502	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(8), ADH1B(12), ADH4(4), ADH5(2), ADH6(8), ADH7(11), ADHFE1(5), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH7A1(3), ALDH9A1(3)	10651830	86	73	83	24	7	39	17	6	17	0	0.296	1.000	1.000
503	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(14), GBA(7), LPO(7), MPO(15), PRDX6(5), TPO(33)	6754499	81	73	80	38	16	28	15	9	13	0	0.939	1.000	1.000
504	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	B3GNT1(3), B3GNT2(4), B3GNT3(5), B3GNT4(2), B3GNT5(5), B4GALT1(1), B4GALT2(4), B4GALT3(2), B4GALT4(2), FUT1(4), FUT2(1), FUT3(5), FUT5(3), FUT6(4), FUT7(3), FUT9(15), GCNT2(5), ST3GAL6(6), ST8SIA1(6)	12770463	80	72	79	25	9	37	14	8	12	0	0.293	1.000	1.000
505	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(1), JAK1(11), JAK2(16), JAK3(10), PIAS1(2), PIAS3(7), PTPRU(19), REG1A(20), SOAT1(8)	10944552	94	72	92	28	13	33	16	11	21	0	0.392	1.000	1.000
506	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	CARM1(4), DHRS2(6), DHRS3(2), DHRS7(3), DHRSX(3), LCMT1(5), LCMT2(7), METTL2B(5), METTL6(1), PRMT2(2), PRMT3(8), PRMT5(7), PRMT6(7), PRMT7(4), PRMT8(13), WBSCR22(3)	12061465	80	71	78	31	15	22	19	9	15	0	0.811	1.000	1.000
507	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(4), IFNB1(7), JAK1(11), PTPRU(19), REG1A(20), STAT1(7), STAT2(6), TYK2(5)	10025136	79	70	77	18	9	37	8	10	15	0	0.0398	1.000	1.000
508	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(7), DUSP1(1), IKBKAP(6), IKBKB(9), LTA(3), MAP3K1(7), NFKB1(6), NFKBIA(4), RELA(3), RIPK1(11), TANK(3), TNFAIP3(6), TNFRSF1B(2), TRAF1(2), TRAF2(5), TRAF3(4)	18085983	79	70	79	33	8	25	21	9	16	0	0.954	1.000	1.000
509	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(5), GNAQ(5), GNB1(2), GNGT1(6), HTR2C(8), PLCB1(52), TUB(11)	5767938	89	70	88	27	9	44	14	8	14	0	0.416	1.000	1.000
510	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(4), CHAT(22), CHKA(4), PCYT1A(2), PDHA1(5), PDHA2(29), PEMT(2), SLC18A3(19)	5570894	87	69	86	35	18	38	15	3	13	0	0.756	1.000	1.000
511	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(3), B3GNT2(4), B3GNT7(5), B4GALT1(1), B4GALT2(4), B4GALT3(2), B4GALT4(2), CHST1(17), CHST2(14), CHST4(3), CHST6(7), FUT8(7), ST3GAL1(4), ST3GAL2(4), ST3GAL3(4), ST3GAL4(4)	9963065	85	69	84	41	14	31	21	6	13	0	0.950	1.000	1.000
512	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(20), ACACB(28), FASN(18), MCAT(3), OLAH(8), OXSM(5)	12381899	82	68	82	27	15	32	14	7	14	0	0.502	1.000	1.000
513	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(5), AOC2(6), AOC3(11), CES1(8), DDHD1(11), ESCO1(10), ESCO2(4), LIPA(2), NAT6(1), PLA1A(6), PNPLA3(4), PPME1(6), PRDX6(5)	20439259	79	68	79	24	12	24	17	13	13	0	0.565	1.000	1.000
514	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(9), APAF1(10), BCL2(5), CASP3(5), CASP9(6), CYCS(2), DAXX(8), FAS(4), FASLG(10), HSPB1(1), HSPB2(1), IL1A(4), MAPKAPK2(2), MAPKAPK3(3), TNF(2)	9129702	72	68	72	30	2	34	18	10	8	0	0.939	1.000	1.000
515	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(10), ARHGAP5(17), ARHGDIB(2), CASP1(8), CASP10(7), CASP3(5), CASP8(6), CASP9(6), CYCS(2), GZMB(6), JUN(3), PRF1(8)	10442703	80	65	80	26	3	35	16	14	12	0	0.786	1.000	1.000
516	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(3), GRB2(6), IL2RG(5), IL4(1), IL4R(10), IRS1(20), JAK1(11), JAK3(10), RPS6KB1(3), SHC1(6), STAT6(2)	11837408	77	65	76	28	15	28	14	11	9	0	0.700	1.000	1.000
517	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(4), ACADM(8), ACADS(1), ACADVL(2), ACSL1(12), ACSL3(4), ACSL4(7), CPT1A(11), CPT2(3), EHHADH(13), HADHA(3), PECR(3), SCP2(4), SLC25A20(1)	13533556	76	64	75	17	11	23	13	13	16	0	0.144	1.000	1.000
518	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(1), CAMK1G(2), HDAC9(48), MEF2A(2), MEF2B(2), MEF2C(6), MEF2D(4), MYOD1(7), YWHAH(1)	6195060	73	64	73	24	8	28	13	6	16	2	0.627	1.000	1.000
519	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(15), CD44(7), CSF1(1), FCGR3A(9), IL1B(1), IL6R(8), SELL(9), SPN(4), TGFB1(3), TGFB2(10), TNF(2), TNFRSF1B(2), TNFRSF8(11), TNFSF8(1)	10550242	83	64	81	28	8	40	15	6	14	0	0.407	1.000	1.000
520	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(9), CD3D(2), CD3E(2), GZMB(6), HLA-A(8), ICAM1(2), ITGAL(26), ITGB2(8), PRF1(8)	7018562	71	63	70	26	8	20	16	9	18	0	0.683	1.000	1.000
521	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(8), ENO1(7), GPI(8), HK1(12), PFKL(9), PGAM1(1), PGK1(4), PKLR(16), TPI1(9)	7359403	74	63	74	24	13	24	19	5	13	0	0.418	1.000	1.000
522	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(5), CYSLTR2(12), GPR161(6), GPR171(2), GPR18(4), GPR34(5), GPR39(6), GPR45(14), GPR65(14), GPR68(1), GPR75(5)	7970124	74	63	73	23	9	29	23	4	9	0	0.376	1.000	1.000
523	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(4), CHPT1(3), LCMT1(5), LCMT2(7), METTL2B(5), METTL6(1), PCYT1A(2), PCYT1B(3), PRMT2(2), PRMT3(8), PRMT5(7), PRMT6(7), PRMT7(4), PRMT8(13), WBSCR22(3)	11287042	74	63	72	29	15	19	19	8	13	0	0.852	1.000	1.000
524	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARF1(1), ARFGAP1(5), ARFGAP3(5), ARFGEF2(14), CLTA(1), COPA(14), GBF1(17), GPLD1(10), KDELR1(1), KDELR3(3)	13048441	71	62	71	17	7	25	18	11	10	0	0.226	1.000	1.000
525	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(9), CYP11A1(5), CYP11B2(24), CYP17A1(6), HSD11B1(9), HSD3B1(6), HSD3B2(15)	5575349	74	62	73	29	13	28	16	6	10	1	0.567	1.000	1.000
526	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM1(3), CALM2(1), CCL2(2), CCL4(2), CCR5(4), CXCL12(3), CXCR4(6), FOS(3), GNAQ(5), JUN(3), MAPK14(4), MAPK8(2), PLCG1(7), PRKCA(10), PTK2B(14), SYT1(6)	11118315	75	61	75	23	11	30	12	6	16	0	0.437	1.000	1.000
527	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(4), CARS2(3), CTH(2), GOT1(3), GOT2(6), LDHA(10), LDHAL6A(1), LDHAL6B(3), LDHB(4), LDHC(6), SDS(4), SULT1B1(10), SULT1C2(3), SULT1C4(2), SULT4A1(6)	10064685	67	61	67	24	6	32	11	5	13	0	0.790	1.000	1.000
528	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(10), BIRC2(2), BIRC3(4), CASP10(7), CASP3(5), CASP7(3), CASP8(6), CASP9(6), DFFA(3), DFFB(4), GZMB(6), PRF1(8), SCAP(6), SREBF1(3), SREBF2(2)	14452849	75	61	75	22	1	26	18	12	18	0	0.579	1.000	1.000
529	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	CYP51A1(5), DHCR7(6), FDFT1(4), FDPS(5), HMGCR(5), HMGCS1(11), IDI1(2), LSS(10), MVD(2), MVK(4), NSDHL(7), PMVK(2), SQLE(4)	10504983	67	60	65	20	11	18	16	7	14	1	0.497	1.000	1.000
530	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	HS3ST1(8), HS3ST2(7), HS3ST3A1(7), XYLT1(44), XYLT2(3)	5218640	69	59	68	35	20	18	15	7	9	0	0.908	1.000	1.000
531	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	HS3ST1(8), HS3ST2(7), HS3ST3A1(7), XYLT1(44), XYLT2(3)	5218640	69	59	68	35	20	18	15	7	9	0	0.908	1.000	1.000
532	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(5), ACO2(3), AFMID(4), CS(2), GRHPR(4), HAO1(12), HAO2(7), MDH1(3), MDH2(3), MTHFD1(6), MTHFD1L(12), MTHFD2(2)	10822334	63	59	62	24	8	22	11	8	14	0	0.712	1.000	1.000
533	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(2), CLOCK(4), CRY1(7), CRY2(6), CSNK1D(7), CSNK1E(6), NPAS2(5), NR1D1(2), PER1(10), PER2(11), PER3(11)	13642370	71	59	69	18	8	28	17	6	11	1	0.282	1.000	1.000
534	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(2), GNAS(29), GNB1(2), GNGT1(6), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PRKCA(10)	7619071	73	58	70	21	23	28	11	5	5	1	0.455	1.000	1.000
535	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(3), BLVRB(2), HMOX1(3), IL10(2), IL10RA(6), IL10RB(6), IL1A(4), IL6(2), JAK1(11), STAT1(7), STAT3(11), STAT5A(3), TNF(2)	9843447	62	58	62	16	4	15	15	13	15	0	0.461	1.000	1.000
536	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	18	APAF1(10), BAK1(3), BAX(3), BCL2(5), BCL2L1(3), BID(2), BIRC2(2), BIRC3(4), CASP3(5), CASP6(3), CASP7(3), CASP8(6), CASP9(6), CYCS(2), DFFA(3), DFFB(4), DIABLO(1)	10829222	65	58	65	24	2	26	17	6	14	0	0.925	1.000	1.000
537	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	CDC34(2), NRF1(8), UBE2A(7), UBE2B(1), UBE2C(3), UBE2D1(1), UBE2D2(1), UBE2D3(3), UBE2E3(6), UBE2G2(1), UBE2I(2), UBE2J1(3), UBE2L3(1), UBE2L6(1), UBE2M(1), UBE2N(1), UBE2S(2), UBE3A(18)	8388658	62	58	61	19	4	27	12	6	13	0	0.574	1.000	1.000
538	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(26), GNAS(29), GNB1(2), GNGT1(6), PRKACA(3), PRKAR1A(2)	5210467	68	57	65	24	22	23	11	4	6	2	0.704	1.000	1.000
539	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(5), ASPH(6), COPS5(3), CREB1(2), EDN1(1), EP300(11), EPO(6), HIF1A(2), JUN(3), LDHA(10), NOS3(12), P4HB(5), VHL(1)	13589874	67	57	67	21	4	19	18	3	23	0	0.769	1.000	1.000
540	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(1), B3GALNT1(2), B3GALT5(3), FUT1(4), FUT2(1), FUT9(15), GBGT1(2), GLA(9), HEXA(6), NAGA(4), ST3GAL1(4), ST3GAL2(4), ST8SIA1(6)	8572537	61	57	61	31	10	22	17	5	7	0	0.945	1.000	1.000
541	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT1(2), ACAT2(2), ACOT11(4), ACYP2(1), DHRS2(6), DHRS3(2), DHRS7(3), DHRSX(3), ECHS1(4), EHHADH(13), ESCO1(10), ESCO2(4), FN3K(1), GCDH(7), HADHA(3), NAT6(1), PNPLA3(4), YOD1(1)	20889072	71	57	69	23	9	22	18	8	14	0	0.706	1.000	1.000
542	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP5E(1), ATP5O(1), ATP6AP1(3), ATP6V0A1(6), ATP6V0A4(8), ATP6V0B(2), ATP6V0C(4), ATP6V0D1(2), ATP6V1A(6), ATP6V1B1(3), ATP6V1B2(5), ATP6V1C1(7), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3), FDXR(3), SHMT1(2)	12868967	66	57	65	28	9	28	8	8	12	1	0.858	1.000	1.000
543	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(1), FUT1(4), FUT2(1), FUT9(15), GBGT1(2), GLA(9), HEXA(6), NAGA(4), ST3GAL1(4), ST3GAL2(4), ST3GAL4(4), ST8SIA1(6)	8067073	60	56	60	29	7	21	18	5	9	0	0.925	1.000	1.000
544	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(30), EP300(11), ESR1(12), MAPK1(2), MAPK3(3), PELP1(10), SRC(2)	11815841	70	56	70	17	14	25	17	2	12	0	0.147	1.000	1.000
545	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(3), FOSL1(4), FOSL2(3), IFNAR1(4), IFNAR2(7), IFNB1(7), MAPK8(2), NFKB1(6), RELA(3), TNFRSF11A(9), TNFSF11(5), TRAF6(6)	8948107	59	56	59	15	4	22	14	6	13	0	0.397	1.000	1.000
546	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(5), ACO2(3), CS(2), GRHPR(4), HAO1(12), HAO2(7), MDH1(3), MDH2(3), MTHFD1(6), MTHFD1L(12), MTHFD2(2)	10332673	59	55	58	22	6	20	11	8	14	0	0.710	1.000	1.000
547	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(9), ANKRD1(6), CYR61(2), DUSP14(2), EIF4E(4), IFNG(7), IFRD1(4), IL1A(4), IL1R1(2), JUND(1), MYOG(1), NR4A3(7), WDR1(9)	8580866	58	55	58	17	4	19	15	8	11	1	0.607	1.000	1.000
548	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5E(1), ATP5O(1), ATP6AP1(3), ATP6V0A1(6), ATP6V0A4(8), ATP6V0B(2), ATP6V0C(4), ATP6V0D1(2), ATP6V1A(6), ATP6V1B1(3), ATP6V1B2(5), ATP6V1C1(7), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3), SHMT1(2)	12120625	63	54	62	24	9	26	8	8	11	1	0.705	1.000	1.000
549	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(7), DUSP1(1), IKBKAP(6), IKBKB(9), MAP3K1(7), NFKB1(6), NFKBIA(4), RELA(3), TNFAIP3(6), TRAF3(4), TRAF6(6)	14639467	59	54	59	28	5	18	14	7	15	0	0.986	1.000	1.000
550	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5E(1), ATP5O(1), ATP6AP1(3), ATP6V0A1(6), ATP6V0A4(8), ATP6V0B(2), ATP6V0C(4), ATP6V0D1(2), ATP6V1A(6), ATP6V1B1(3), ATP6V1B2(5), ATP6V1C1(7), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3), SHMT1(2)	12120625	63	54	62	24	9	26	8	8	11	1	0.705	1.000	1.000
551	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5E(1), ATP5O(1), ATP6AP1(3), ATP6V0A1(6), ATP6V0A4(8), ATP6V0B(2), ATP6V0C(4), ATP6V0D1(2), ATP6V1A(6), ATP6V1B1(3), ATP6V1B2(5), ATP6V1C1(7), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3), SHMT1(2)	12120625	63	54	62	24	9	26	8	8	11	1	0.705	1.000	1.000
552	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(15), AGT(4), AGTR1(9), AGTR2(6), BDKRB2(3), KNG1(9), NOS3(12), REN(6)	7816341	64	53	64	32	8	31	11	6	8	0	0.896	1.000	1.000
553	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(5), CDKN1A(2), EPO(6), EPOR(2), GRIN1(9), HIF1A(2), JAK2(16), NFKB1(6), NFKBIA(4), RELA(3), SOD2(6)	10072951	61	53	60	19	3	20	18	5	15	0	0.684	1.000	1.000
554	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(5), ACOX3(8), FADS2(4), PLA2G12A(4), PLA2G12B(3), PLA2G1B(2), PLA2G2A(5), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(6), PLA2G4A(21), PLA2G6(3)	8123278	67	53	67	24	6	28	17	8	8	0	0.710	1.000	1.000
555	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(11), JAK2(16), JAK3(10), MAPK1(2), MAPK3(3), STAT3(11), TYK2(5)	9257582	58	53	58	21	7	15	13	12	11	0	0.789	1.000	1.000
556	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(3), CYP2A13(13), CYP2A6(6), CYP2A7(7), NAT1(4), NAT2(5), XDH(18)	6470567	56	52	56	23	7	28	10	7	4	0	0.633	1.000	1.000
557	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(6), HK1(12), HK2(11), HK3(22), IMPA1(1), IMPA2(1), ISYNA1(1), PGM1(3), PGM3(3), TGDS(1)	9290356	61	52	61	26	17	19	11	6	8	0	0.811	1.000	1.000
558	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	AKR1A1(1), ECHS1(4), EHHADH(13), HADH(2), HADHA(3), HSD17B10(2), HSD17B4(8), SIRT1(2), SIRT2(2), SIRT5(1), SIRT7(4), VNN2(14)	9526617	56	52	54	15	8	19	13	5	11	0	0.436	1.000	1.000
559	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(11), POLR2A(11), POLR2B(10), POLR2C(4), POLR2D(3), POLR2E(2), POLR2F(1), POLR2G(1), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(2), POLRMT(8)	10638297	57	52	57	19	7	19	16	5	10	0	0.686	1.000	1.000
560	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACOX1(5), ACOX3(8), ELOVL2(6), ELOVL5(1), ELOVL6(2), FADS2(4), FASN(18), HADHA(3), HSD17B12(4), PECR(3), SCD(3)	11182281	57	51	57	14	9	23	10	8	7	0	0.171	1.000	1.000
561	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	ALDOA(4), CTSD(3), ESR1(12), GREB1(31), HSPB1(1), HSPB2(1), MTA1(6), MTA3(2), PDZK1(3), TUBA8(1)	8607341	64	51	63	25	13	19	15	3	14	0	0.632	1.000	1.000
562	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(1), CBS(1), CTH(2), GGT1(1), MARS(5), MARS2(13), MAT1A(7), MAT2B(3), PAPSS1(5), PAPSS2(10), SCLY(4), SEPHS1(4)	9934310	56	51	56	27	7	23	10	5	11	0	0.943	1.000	1.000
563	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(6), HK1(12), HK2(11), HK3(22), IMPA1(1), PGM1(3), PGM3(3), TGDS(1)	8218088	59	51	59	25	17	19	11	5	7	0	0.831	1.000	1.000
564	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREB1(2), CREM(3), FOS(3), JUN(3), MAPK3(3), OPRK1(12), POLR2A(11), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2)	10358187	61	50	61	27	11	23	14	6	6	1	0.926	1.000	1.000
565	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(2), ADSS(6), DHFR(2), HPRT1(1), IMPDH1(7), MTHFD2(2), OAZ1(1), POLB(4), POLD1(7), POLG(12), PRPS2(4), RRM1(6), SRM(2)	9912415	56	50	56	13	8	19	11	9	9	0	0.223	1.000	1.000
566	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	HRAS(2), MMP14(4), MMP2(24), MMP9(10), RECK(9), TIMP1(1), TIMP2(2), TIMP3(4), TIMP4(4)	6044842	60	50	60	24	9	22	15	4	10	0	0.792	1.000	1.000
567	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(3), IARS(9), LARS(14), LARS2(2), PDHA1(5), PDHA2(29)	8106531	62	50	62	19	8	26	9	7	12	0	0.669	1.000	1.000
568	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(4), PSMA3(2), PSMA4(2), PSMA5(1), PSMA6(4), PSMA7(5), PSMB1(2), PSMB5(1), PSMB6(1), PSMD14(2), RPN1(3), RPN2(4), UBE2A(7), UBE3A(18)	10426013	56	49	56	13	5	22	14	9	6	0	0.258	1.000	1.000
569	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(10), CKM(4), EIF4E(4), FBL(8), LDHA(10), LDHB(4), LDHC(6), MAPK14(4), NCL(10)	7183673	60	49	60	18	9	24	8	7	12	0	0.530	1.000	1.000
570	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	AKR1B10(10), DHRS2(6), DHRS3(2), DHRS7(3), DHRSX(3), HSD3B7(7), PON1(3), PON2(2), PON3(5), RDH11(4), RDH12(3), RDH13(1), RDH14(2)	7249371	51	48	51	18	5	24	11	3	8	0	0.583	1.000	1.000
571	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(3), ACO1(5), ACO2(3), ACSS1(5), ACSS2(4), FH(13), IDH1(6), IDH2(2), MDH1(3), MDH2(3), SUCLA2(5)	10748299	52	48	52	19	5	16	5	10	16	0	0.710	1.000	1.000
572	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNA1(2), IFNAR1(4), IFNAR2(7), IFNB1(7), JAK1(11), STAT1(7), STAT2(6), TYK2(5)	8678322	49	47	49	12	4	19	9	9	8	0	0.319	1.000	1.000
573	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(10), BAK1(3), BAX(3), BCL10(4), BCL2(5), BCL2L1(3), BCL2L11(4), BID(2), CASP9(6), CES1(8)	8626031	48	47	48	22	5	22	11	6	4	0	0.970	1.000	1.000
574	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(4), PSMA3(2), PSMA4(2), PSMA5(1), PSMA6(4), PSMA7(5), PSMB1(2), PSMB5(1), PSMB6(1), PSMC2(3), PSMD1(8), PSMD11(7), PSMD12(4), PSMD13(4), PSMD2(3), PSMD6(2)	12929204	53	45	53	10	5	27	10	5	6	0	0.117	1.000	1.000
575	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(6), FDFT1(4), FDPS(5), HMGCR(5), IDI1(2), LSS(10), MVD(2), MVK(4), NQO2(3), PMVK(2), SQLE(4)	8778102	47	44	45	18	9	11	11	8	8	0	0.787	1.000	1.000
576	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(3), CS(2), FH(13), IDH2(2), MDH1(3), OGDH(10), SDHA(8), SUCLA2(5)	7617727	46	44	45	16	7	14	7	6	12	0	0.607	1.000	1.000
577	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(3), AASDH(15), AASDHPPT(4), AASS(20), KARS(8)	5621956	50	44	50	17	5	25	9	7	4	0	0.754	1.000	1.000
578	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	CREB1(2), GRB2(6), HRAS(2), PTK2B(14), SHC1(6), SOS1(17), SRC(2)	7080935	49	43	47	14	9	15	13	6	6	0	0.461	1.000	1.000
579	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(12), GAD1(7), HDC(16), PNMT(1), TH(7), TPH1(8)	4758284	51	43	51	18	10	20	9	3	9	0	0.524	1.000	1.000
580	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(11), LDLR(9), MBTPS1(7), MBTPS2(7), SCAP(6), SREBF1(3), SREBF2(2)	9331112	45	43	45	14	5	14	13	4	7	2	0.572	1.000	1.000
581	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GSR(5), GSS(4), NFKB1(6), NOX1(8), RELA(3), SOD1(1), TNF(2), XDH(18)	8029467	47	42	47	21	3	22	11	6	5	0	0.903	1.000	1.000
582	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(2), CDC25A(4), CDC25B(1), CDC25C(8), CSK(2), GRB2(6), PRKCA(10), PTPRA(11), SRC(2)	7390964	46	42	46	18	8	17	8	5	8	0	0.752	1.000	1.000
583	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(9), CAPN1(2), CAPNS1(1), CAPNS2(2), CDK5(3), CDK5R1(3), CSNK1A1(2), CSNK1D(7), GSK3B(4), MAPT(15), PPP2CA(1)	7346627	49	41	49	19	8	22	9	4	6	0	0.785	1.000	1.000
584	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(9), ACTR2(4), ACTR3(2), ARPC1A(3), ARPC1B(4), ARPC2(3), ARPC3(2), CDC42(1), WASF1(10), WASL(7)	6550870	45	41	45	19	4	13	13	5	10	0	0.933	1.000	1.000
585	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(7), MAPK14(4), MAPK8(2), NFKB1(6), RELA(3), TNFRSF13B(3), TNFRSF13C(2), TNFSF13B(1), TRAF2(5), TRAF3(4), TRAF5(5), TRAF6(6)	11647677	48	41	48	26	5	13	9	7	14	0	0.996	1.000	1.000
586	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(5), ACO2(3), FH(13), IDH1(6), IDH2(2), MDH1(3), MDH2(3), SDHB(1), SUCLA2(5)	7200223	41	39	41	15	3	14	3	8	13	0	0.715	1.000	1.000
587	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAD(1), ALAS1(2), ALAS2(6), CPO(4), FECH(4), GATA1(6), HBA2(2), HBB(9), HMBS(5), UROS(2)	6361596	41	38	41	25	2	21	8	3	7	0	0.992	1.000	1.000
588	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	9	CASP3(5), CASP7(3), DFFA(3), DFFB(4), GZMB(6), HMGB1(2), TOP2A(10), TOP2B(10)	7110700	43	38	43	10	1	10	11	5	16	0	0.625	1.000	1.000
589	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(2), ACAT2(2), BDH1(4), BDH2(2), HMGCL(1), HMGCS1(11), HMGCS2(7), OXCT1(7), OXCT2(2)	5814519	38	36	38	15	3	11	12	3	8	1	0.896	1.000	1.000
590	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(3), B4GALT1(1), B4GALT2(4), B4GALT3(2), B4GALT5(6), FUT8(7), ST3GAL1(4), ST3GAL2(4), ST3GAL3(4), ST3GAL4(4)	6322492	39	36	38	22	6	13	9	2	9	0	0.970	1.000	1.000
591	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(18), GNA12(1), PRKACB(9), PRKACG(4), PRKAG1(1), PRKAR2A(3), PRKAR2B(2)	8129650	38	34	38	11	5	15	10	4	4	0	0.637	1.000	1.000
592	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	B3GNT1(3), FUT1(4), FUT2(1), FUT9(15), GCNT2(5), ST8SIA1(6)	4888396	34	33	33	17	3	17	6	3	5	0	0.836	1.000	1.000
593	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(4), CTH(2), GOT1(3), GOT2(6), LDHA(10), LDHB(4), LDHC(6)	5511713	35	33	35	12	4	13	5	4	9	0	0.720	1.000	1.000
594	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(6), DCN(5), FMOD(3), KERA(7), LUM(17)	2934698	38	33	38	12	3	10	14	5	6	0	0.634	1.000	1.000
595	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(12), EIF2AK4(7), EIF2S2(3), EIF2S3(3), EIF5(1), GSK3B(4), PPP1CA(2)	9270131	32	32	32	11	2	14	5	3	8	0	0.825	1.000	1.000
596	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(14), BCKDK(2), CBS(1), CTH(2), MUT(13)	3908921	32	32	31	15	3	11	6	4	8	0	0.928	1.000	1.000
597	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CASP3(5), CD36(4), FOS(3), FYN(8), JUN(3), MAPK14(4), THBS1(8)	5972133	35	31	35	10	5	11	6	2	11	0	0.591	1.000	1.000
598	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(4), CYCS(2), GPD2(9), NDUFA1(2), SDHA(8), SDHB(1), SDHD(3), UQCRC1(2)	5355877	31	30	30	17	8	11	8	0	4	0	0.982	1.000	1.000
599	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	FABP6(3), LDLR(9), NR0B2(3), NR1H3(4), NR1H4(14), RXRA(1)	4348769	34	30	34	13	7	13	9	2	3	0	0.640	1.000	1.000
600	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(10), APOBEC1(1), APOBEC2(1), APOBEC3A(3), APOBEC3B(3), APOBEC3C(1), APOBEC3F(1), APOBEC3G(5), APOBEC4(7)	5940270	32	30	31	14	5	12	4	4	7	0	0.870	1.000	1.000
601	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(3), PLCG1(7), PRKCA(10), PTK2B(14)	5418338	34	30	34	12	12	11	5	2	4	0	0.550	1.000	1.000
602	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(9), ADORA2A(3), ADORA2B(1), ADORA3(4), LTB4R(5), P2RY1(4), P2RY2(3), P2RY6(2)	4799440	31	30	31	15	10	6	6	4	5	0	0.807	1.000	1.000
603	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	CDK5(3), FOSB(2), GRIA2(28), JUND(1), PPP1R1B(1)	2959877	35	29	35	14	4	13	10	0	8	0	0.776	1.000	1.000
604	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(1), ALAS1(2), ALAS2(6), CPOX(4), FECH(4), HMBS(5), PPOX(7), UROS(2)	6125365	31	29	31	20	1	10	11	3	6	0	0.997	1.000	1.000
605	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	B3GALT1(5), B3GALT2(4), B3GALT5(3), B3GNT5(5), FUT1(4), FUT2(1), FUT3(5), ST3GAL3(4), ST3GAL4(4)	5787730	35	29	35	10	8	12	7	3	5	0	0.362	1.000	1.000
606	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS2(6), DHRS3(2), DHRS7(3), DHRSX(3), ESCO1(10), ESCO2(4), NAT6(1), PNPLA3(4)	13355738	33	29	33	15	2	10	9	4	8	0	0.957	1.000	1.000
607	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BIRC3(4), CASP8(6), FADD(2), RIPK1(11), TNF(2), TNFRSF1B(2), TRADD(2), TRAF2(5)	6647115	34	29	34	10	4	10	12	4	4	0	0.525	1.000	1.000
608	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(10), EPHX2(3), HSD3B7(7), RDH11(4), RDH12(3), RDH13(1), RDH14(2)	3845148	30	27	30	12	5	15	6	1	3	0	0.650	1.000	1.000
609	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(3), CS(2), MDH1(3), ME1(3), PC(9), PDHA1(5), SLC25A11(3)	7432397	28	27	28	11	4	7	4	9	4	0	0.739	1.000	1.000
610	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	AOC2(6), AOC3(11), CES1(8), ESD(2)	4884444	27	25	27	10	6	10	4	3	4	0	0.528	1.000	1.000
611	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(5), CHRNA1(16), SNAP25(5)	2633838	26	25	26	11	4	8	5	3	6	0	0.845	1.000	1.000
612	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(1), ST3GAL1(4), ST3GAL2(4), ST3GAL4(4), ST3GAL5(3), ST6GALNAC2(2), ST6GALNAC4(1), ST8SIA1(6)	4525222	25	25	25	18	2	5	10	1	7	0	0.996	1.000	1.000
613	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(2), CCL2(2), CSF1(1), IL6(2), LDLR(9), LPL(8)	4286004	24	23	24	11	5	7	4	5	3	0	0.872	1.000	1.000
614	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(4), PSMA3(2), PSMA4(2), PSMA5(1), PSMA6(4), PSMA7(5), PSMB1(2), PSMB10(1), PSMB5(1), PSMB6(1)	7053300	23	21	23	7	4	8	6	3	2	0	0.593	1.000	1.000
615	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CCL2(2), CSF1(1), IL1B(1), MST1R(7), TNF(2)	5164336	13	13	13	9	1	7	0	3	2	0	0.931	1.000	1.000
616	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1	CMBL(1)	412157	1	1	1	2	0	0	0	1	0	0	0.987	1.000	1.000