rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(8), GOT1(3), GOT2(6), TAT(9), TYR(29)	3808360	55	53	55	9	8	22	11	6	8	0	0.0326	0.604	1.000
2	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(3), GOT2(6), TAT(9)	2128311	18	18	18	2	5	7	3	2	1	0	0.0759	0.624	1.000
3	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(8), IFNG(7), IL12A(2), IL12B(3), IL2(7)	2403481	27	26	27	5	1	16	0	1	8	1	0.201	0.733	1.000
4	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	6	ATM(53), ATR(26), CDC25C(8), CHEK1(7), CHEK2(10), YWHAH(1)	12280972	105	90	103	9	9	26	18	19	31	2	0.000478	0.795	1.000
5	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(7)	584333	7	7	7	3	2	1	0	2	2	0	0.742	0.926	1.000
6	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(6), SLPI(1)	1382720	7	7	6	1	1	2	1	1	2	0	0.354	0.930	1.000
7	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(2), TPI1(9)	1324024	11	10	11	3	1	3	5	0	2	0	0.593	0.961	1.000
8	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(7), PAPSS1(5), PAPSS2(10), SULT1A2(5), SULT1E1(11), SULT2A1(6), SUOX(5)	4954097	49	45	49	7	3	21	9	7	9	0	0.0373	0.977	1.000
9	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(8), GLS2(6), GLUD1(4), GLUD2(15)	3672284	33	31	33	5	0	17	9	2	5	0	0.130	0.984	1.000
10	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD28(4), CD4(8), CD80(3), HLA-DRA(3), HLA-DRB1(5), IL10(2), IL2(7), IL4(1)	3223968	33	29	29	7	1	14	1	3	14	0	0.418	0.988	1.000
11	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(1), LIPT1(2)	1235104	3	3	3	0	0	1	0	1	1	0	0.495	0.990	1.000
12	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3D(2), CD3E(2)	923089	4	4	4	2	0	0	1	1	2	0	0.858	0.992	1.000
13	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(4), FDPS(5), IDI1(2), SQLE(4)	2563848	15	15	15	3	2	5	4	1	3	0	0.434	0.993	1.000
14	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(8), ALDH1A2(8), RDH5(1)	3156193	17	17	17	2	1	7	3	4	2	0	0.122	0.993	1.000
15	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	11	CCNE1(7), CDK2(1), CDKN1B(5), CKS1B(1), CUL1(14), E2F1(3), NEDD8(3), SKP2(3), TFDP1(10), UBE2M(1)	5488264	48	38	48	6	5	13	12	6	12	0	0.0228	0.995	1.000
16	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	7	CCNE1(7), CDC34(2), CDK2(1), CUL1(14), E2F1(3), FBXW7(15), TFDP1(10)	5194496	52	38	52	6	6	19	10	6	11	0	0.00765	0.995	1.000
17	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(3), SUCLA2(5)	1692843	8	7	8	2	0	4	0	2	2	0	0.527	0.995	1.000
18	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD28(4), CD4(8), HLA-DRA(3), HLA-DRB1(5)	1927106	20	20	16	6	1	9	1	2	7	0	0.708	0.996	1.000
19	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(4), FDPS(5), GGPS1(2), IDI1(2), IDI2(1), SQLE(4)	3440819	18	18	18	3	2	7	5	1	3	0	0.308	0.997	1.000
20	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(8), HLCS(3), SPCS1(1), SPCS3(2)	2479058	14	14	14	3	1	6	5	1	1	0	0.385	0.997	1.000
21	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(6), PGLYRP2(9)	1454837	15	15	14	5	0	4	4	3	4	0	0.632	0.998	1.000
22	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(53), CDC25A(4), CDC25B(1), CDC25C(8), CHEK1(7), MYT1(24), WEE1(4), YWHAH(1)	11082061	102	86	100	12	10	26	15	16	33	2	0.00197	0.998	1.000
23	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(6), ARG1(2), GLS(8), GLUD1(4), OAT(3), PRODH(4)	4404565	27	26	27	4	3	11	6	2	5	0	0.131	0.999	1.000
24	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(3), MTMR1(11), MTMR2(2), MTMR6(9), NFS1(5), PHPT1(1), THTPA(1), TPK1(11)	5148488	43	39	41	7	2	17	12	6	6	0	0.111	0.999	1.000
25	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(13), CYP2C9(8)	1642731	21	21	21	7	3	9	4	2	3	0	0.625	0.999	1.000
26	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(2), GSTZ1(2), HGD(5)	1795382	9	8	9	4	0	2	0	2	5	0	0.846	0.999	1.000
27	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	8	CCNA1(7), CCNE1(7), CDC34(2), CDK2(1), CUL1(14), E2F1(3), SKP2(3), TFDP1(10)	5427356	47	36	47	6	5	19	12	6	5	0	0.0164	0.999	1.000
28	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALT(5), TGDS(1), UGDH(6), UGP2(4), UXS1(6)	3969223	22	21	22	4	2	8	4	3	5	0	0.365	1.000	1.000
29	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(1), ECHS1(4), EHHADH(13), HADHA(3), SDS(4)	3872652	25	23	24	5	4	8	5	4	4	0	0.265	1.000	1.000
30	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(2), ALDOA(4), ALDOB(8), ALDOC(2), TPI1(9)	3157676	25	21	25	5	3	9	7	0	6	0	0.285	1.000	1.000
31	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALT(5), TGDS(1), UGDH(6), UXS1(6)	3115757	18	17	18	4	2	8	3	2	3	0	0.432	1.000	1.000
32	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	10	ATM(53), CDC25A(4), CDC25B(1), CDC25C(8), CDK2(1), CDK4(3), CHEK1(7), MYT1(24), WEE1(4), YWHAH(1)	12090440	106	90	103	13	12	27	15	16	34	2	0.00203	1.000	1.000
33	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	12	CCNA1(7), CCNA2(6), CCND1(3), CCNE1(7), CCNE2(3), CDK2(1), CDK4(3), CDKN1B(5), E2F1(3), E2F2(5), E2F4(5), PRB1(5)	6694029	53	47	52	8	7	22	10	3	11	0	0.0266	1.000	1.000
34	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CCR5(4), CD28(4), CD3D(2), CD3E(2), CD4(8)	2606736	20	20	20	6	1	9	1	4	5	0	0.494	1.000	1.000
35	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCL11(2), CCR3(4), HLA-DRA(3), HLA-DRB1(5), IL3(4), IL5(2)	2466150	20	20	16	6	0	5	5	4	6	0	0.842	1.000	1.000
36	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCL11(2), CCR3(4), CD4(8), HLA-DRA(3), HLA-DRB1(5), IL1B(1), IL4(1), IL5(2), IL5RA(9), IL6(2)	4330878	37	36	33	9	1	11	7	5	13	0	0.548	1.000	1.000
37	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(4), ACP2(4), ACP5(4), ACPP(8), ACPT(7), ENPP1(14), ENPP3(19), FLAD1(5), TYR(29)	7810350	94	85	93	17	10	37	19	11	17	0	0.0332	1.000	1.000
38	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(4), CDC25B(1), CDK7(3), CDKN1A(2), CHEK1(7), NEK1(11), WEE1(4)	5532285	32	30	32	5	1	11	8	5	7	0	0.214	1.000	1.000
39	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	ATP6V0C(4), GGT1(1), SHMT1(2), SHMT2(2)	3314036	9	9	8	0	2	3	2	1	1	0	0.0776	1.000	1.000
40	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ2(1), COQ3(5), COQ5(3), COQ6(1), COQ7(5), NDUFA12(5), NDUFA13(1), NDUFB11(6)	3215199	27	24	27	8	7	6	3	3	8	0	0.553	1.000	1.000
41	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(2), ACAT2(2), HMGCL(1), OXCT1(7)	2736802	12	12	12	9	1	2	3	2	4	0	0.994	1.000	1.000
42	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(17), PARK2(15), SNCA(5), SNCAIP(12), UBE2E2(4), UBE2G2(1), UBE2L3(1), UBE2L6(1)	5191088	56	53	56	13	7	26	12	2	9	0	0.175	1.000	1.000
43	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(4), ACADM(8), ACADS(1), ACAT1(2), ECHS1(4), HADHA(3)	4325350	22	21	22	7	0	4	5	4	9	0	0.808	1.000	1.000
44	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(8), PLCD1(4), PRKCA(10), TGM2(6)	3986370	28	25	28	8	5	12	3	5	3	0	0.341	1.000	1.000
45	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	CDK5(3), CDK5R1(3), EGR1(6), HRAS(2), KLK2(10), MAP2K1(10), MAP2K2(1), MAPK1(2), MAPK3(3), NGFR(5), RAF1(6)	6499475	51	47	47	10	6	22	14	4	5	0	0.0444	1.000	1.000
46	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNA1(2), IFNB1(7), IFNG(7), IL10(2), IL12A(2), IL12B(3), IL13(2), IL15(6), IL16(28), IL1A(4), IL2(7), IL3(4), IL4(1), IL5(2), IL6(2), IL9(1), LTA(3), TNF(2)	8021597	85	70	85	19	5	47	10	10	12	1	0.0488	1.000	1.000
47	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA2(2), ACAT1(2), ACAT2(2), ECHS1(4), EHHADH(13), HADHA(3), HADHB(10), SDS(4)	6711531	40	37	39	9	4	11	13	6	6	0	0.325	1.000	1.000
48	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH9A1(3)	6404267	49	44	49	11	5	19	11	7	7	0	0.165	1.000	1.000
49	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH9A1(3)	6404267	49	44	49	11	5	19	11	7	7	0	0.165	1.000	1.000
50	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	13	ARF1(1), ARF3(1), CCND1(3), CDK2(1), CDK4(3), CDKN1A(2), CDKN1B(5), E2F1(3), E2F2(5), MDM2(5), NXT1(2), PRB1(5)	5620376	36	33	35	8	5	15	5	3	8	0	0.197	1.000	1.000
51	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(12), ESR2(6), ITPKA(2), PDE1A(17), PDE1B(13), PLCB1(52), PLCB2(12), PRL(3), TRH(4), VIP(6)	8866426	127	99	125	28	19	53	24	10	21	0	0.0217	1.000	1.000
52	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(7), ENO2(2), ENO3(3), FARS2(5), GOT1(3), GOT2(6), PAH(11), TAT(9), YARS(3)	6722782	49	46	49	10	7	19	11	4	8	0	0.113	1.000	1.000
53	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	BCL2(5), CASP3(5), CASP8(6), CFLAR(2)	3134220	18	17	18	8	1	6	7	1	3	0	0.873	1.000	1.000
54	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(4), SEC61A2(6), SRP54(5), SRP68(4), SRP72(9), SRPR(5)	6095457	33	29	32	7	2	8	12	2	9	0	0.557	1.000	1.000
55	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RANBP1(1), RANBP2(34), RANGAP1(4)	6781581	39	36	39	8	6	16	9	4	4	0	0.268	1.000	1.000
56	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	14	EPO(6), FLT3(24), IGF1(4), IL1A(4), IL3(4), IL6(2), IL9(1), KITLG(6), TGFB1(3), TGFB2(10)	6569556	64	57	64	15	6	25	13	6	14	0	0.144	1.000	1.000
57	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	18	ABCB1(45), AKT1(3), ATM(53), BAX(3), CDKN1A(2), CPB2(6), CSNK1A1(2), CSNK1D(7), FHL2(2), GADD45A(2), HIC1(1), HIF1A(2), IGFBP3(4), MAPK8(2), MDM2(5), NFKBIB(3)	16007694	142	121	139	23	11	52	25	18	34	2	0.0116	1.000	1.000
58	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(8), ADH1B(12), ADH4(4), ADH6(8), ADH7(11), ADHFE1(5)	4573767	48	43	45	14	3	25	7	2	11	0	0.465	1.000	1.000
59	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(4), ACP2(4), ACP5(4), ACP6(3), ACPP(8), ACPT(7), ENPP1(14), ENPP3(19), FLAD1(5), LHPP(3), MTMR1(11), MTMR2(2), MTMR6(9), PHPT1(1), TYR(29)	12088037	123	101	121	22	12	52	24	15	20	0	0.0154	1.000	1.000
60	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH9A1(3), ECHS1(4), EHHADH(13), HADHA(3), SDS(4)	9729696	73	64	72	15	8	27	16	11	11	0	0.0769	1.000	1.000
61	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(10), BMPR1A(4), BMPR1B(7), BMPR2(10)	5050548	31	28	30	7	5	8	10	4	4	0	0.329	1.000	1.000
62	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(1), IFNG(7), IFNGR1(7), JAK1(11), JAK2(16), PLA2G2A(5), PTPRU(19), REG1A(20), STAT1(7)	9229358	93	77	91	19	11	37	15	9	20	1	0.0404	1.000	1.000
63	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(7), IFNGR1(7), IFNGR2(4), JAK1(11), JAK2(16), STAT1(7)	6617914	52	50	52	12	6	15	12	7	11	1	0.404	1.000	1.000
64	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(3), CYP2E1(7), NR1I3(9), PTGS1(18), PTGS2(12)	4326176	49	43	48	13	3	24	10	3	9	0	0.170	1.000	1.000
65	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(5), FARSA(5), FARSB(5), GOT1(3), GOT2(6), PAH(11), TAT(9), YARS(3), YARS2(10)	7030650	57	53	57	12	12	19	12	3	11	0	0.0918	1.000	1.000
66	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(2), CLOCK(4), CRY1(7), CRY2(6), CSNK1E(6), PER1(10)	6788509	35	31	33	7	5	12	8	2	8	0	0.247	1.000	1.000
67	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	FUT1(4), FUT2(1), FUT3(5), FUT5(3), FUT6(4), ST3GAL3(4)	3992736	21	19	21	6	5	6	5	2	3	0	0.439	1.000	1.000
68	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(9), CSAD(6), GAD1(7), GAD2(27), GGT1(1)	4611376	50	45	50	14	4	22	10	4	10	0	0.387	1.000	1.000
69	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(2), CCNH(3), CDC25A(4), CDC25B(1), CDC25C(8), CDK7(3), MNAT1(2), SHH(2), XPO1(12)	6942669	37	32	37	8	3	14	8	6	6	0	0.313	1.000	1.000
70	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(9), LPL(8), NR3C1(8), PPARG(8), RXRA(1), TNF(2)	4649244	36	35	36	10	3	14	8	3	7	1	0.359	1.000	1.000
71	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	ANP32A(3), APEX1(3), CREBBP(30), DFFA(3), DFFB(4), GZMA(8), GZMB(6), PRF1(8), SET(1)	8510668	66	56	66	11	9	26	14	5	12	0	0.0283	1.000	1.000
72	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	6	HDAC1(4), MAX(8), MYC(4), SP1(6), SP3(6), WT1(16)	5031748	44	41	43	12	6	16	5	3	14	0	0.366	1.000	1.000
73	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(2), IL13RA1(3), IL13RA2(13), IL4R(10), JAK1(11), JAK2(16), TYK2(5)	8379151	60	54	60	13	8	20	15	8	9	0	0.166	1.000	1.000
74	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(2), IL13RA1(3), IL13RA2(13), IL4R(10), JAK1(11), JAK2(16), TYK2(5)	8379151	60	54	60	13	8	20	15	8	9	0	0.166	1.000	1.000
75	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(6), F13B(28), HSD17B1(2), HSD17B2(6), HSD17B3(3), HSD17B4(8), HSD17B7(3), HSD3B1(6), HSD3B2(15)	6540842	77	66	76	20	7	33	16	8	12	1	0.214	1.000	1.000
76	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA1(2), NDUFA10(5), NDUFA11(1), NDUFA4(2), NDUFA5(2), NDUFA8(5), NDUFB2(2), NDUFB4(1), NDUFB5(6), NDUFB6(2), NDUFS1(10), NDUFS2(4), NDUFV1(2), NDUFV2(1)	5579121	45	38	45	10	5	19	7	3	10	1	0.233	1.000	1.000
77	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH7A1(3), ALDH9A1(3), MIOX(2), UGDH(6)	6783953	44	39	44	11	4	18	12	4	6	0	0.283	1.000	1.000
78	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	14	APAF1(10), ATM(53), BAX(3), BCL2(5), CCND1(3), CCNE1(7), CDK2(1), CDK4(3), CDKN1A(2), E2F1(3), GADD45A(2), MDM2(5), PCNA(1), TIMP3(4)	12505176	102	84	99	19	11	31	21	16	21	2	0.0772	1.000	1.000
79	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	5	ADAM17(8), ERBB4(51), NRG2(3), PRKCA(10), PSEN1(6)	6213389	78	69	78	21	10	32	13	10	13	0	0.305	1.000	1.000
80	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(6), CD34(13), CD3D(2), CD3E(2), CD4(8), CD58(1), CD8A(4), IL3(4), IL6(2), KITLG(6)	4993395	48	39	47	15	4	21	6	4	13	0	0.469	1.000	1.000
81	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	28	CD4(8), CSF1(1), HLA-DRA(3), HLA-DRB1(5), IFNA1(2), IFNB1(7), IFNG(7), IL10(2), IL12A(2), IL12B(3), IL13(2), IL15(6), IL1A(4), IL2(7), IL3(4), IL4(1), IL5(2), IL6(2), IL7(2), LTA(3), PDGFA(5), TGFB1(3), TGFB2(10), TNF(2)	10608184	93	81	89	22	4	41	12	13	22	1	0.144	1.000	1.000
82	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(22), PDXK(2), PDXP(1), PNPO(2), PSAT1(5)	3885247	32	28	32	10	2	13	9	5	3	0	0.594	1.000	1.000
83	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	BPNT1(7), CHST11(2), CHST12(6), CHST13(3), PAPSS1(5), PAPSS2(10), SULT1A1(5), SULT1A2(5), SULT1E1(11), SULT2A1(6), SULT2B1(2), SUOX(5)	7381636	67	55	66	16	8	24	13	9	13	0	0.133	1.000	1.000
84	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(9), RAB27A(1), RAB4A(2), RAB5A(2), RAB6A(1)	3425847	15	14	15	9	1	5	5	3	1	0	0.974	1.000	1.000
85	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(3), AASDHPPT(4), AASS(20), KARS(8)	3810563	35	30	35	10	4	18	5	5	3	0	0.530	1.000	1.000
86	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	ADAM17(8), DLL1(5), FURIN(7), NOTCH1(26), PSEN1(6)	6936866	52	47	52	13	13	14	7	7	11	0	0.156	1.000	1.000
87	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(4), CD3D(2), CD3E(2), IFNG(7), IL2(7), IL2RA(6), IL4(1), TGFB1(3), TGFB2(10), TGFBR1(7), TGFBR2(7), TGFBR3(19), TOB1(4), TOB2(4)	8525310	83	75	83	21	5	36	14	5	22	1	0.238	1.000	1.000
88	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(3), CAMP(4), DAG1(3), GNAQ(5), ITPKA(2), ITPKB(7)	4773910	24	23	24	8	3	8	7	3	3	0	0.607	1.000	1.000
89	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(9), ALPL(3), ALPP(13), ALPPL2(4), DHFR(2), FPGS(3), GCH1(3), GGH(9), SPR(3)	5125898	49	42	49	15	2	16	14	5	12	0	0.462	1.000	1.000
90	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(2), ACAT2(2), ACYP2(1), ECHS1(4), EHHADH(13), GCDH(7), HADHA(3), SDHB(1), SDS(4)	6259671	37	33	35	10	6	10	9	5	7	0	0.448	1.000	1.000
91	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	ASRGL1(3), GBA(7), GGT1(1), SHMT1(2), SHMT2(2)	4406742	15	15	15	6	2	5	4	1	3	0	0.822	1.000	1.000
92	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	11	ASAH1(3), BFAR(5), CAMP(4), CREB1(2), CREB5(18), MAPK1(2), RAF1(6), SNX13(9), SRC(2)	7759959	51	43	49	11	6	24	15	1	5	0	0.185	1.000	1.000
93	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CCR5(4), CD2(6), CD3D(2), CD3E(2), CD4(8), CXCR3(3), IFNG(7), IL12A(2), IL12B(3), IL12RB1(5), IL12RB2(15), JAK2(16), STAT4(11), TYK2(5)	11741422	89	72	89	19	7	36	15	10	20	1	0.0702	1.000	1.000
94	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(2), ECHS1(4), HADH(2), HADHA(3), HADHB(10), HSD17B10(2), HSD17B4(8), MECR(2), PPT1(2), PPT2(6)	6827328	41	40	40	11	3	11	14	5	8	0	0.517	1.000	1.000
95	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(2), ASL(4), CPS1(71), GLS(8), GLUD1(4), GOT1(3)	6263846	92	82	91	25	5	40	17	13	17	0	0.451	1.000	1.000
96	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	14	CD4(8), CD8A(4), CSF1(1), EPO(6), IL2(7), IL3(4), IL4(1), IL5(2), IL6(2), IL7(2), IL9(1)	4807995	38	33	38	13	1	18	7	4	8	0	0.623	1.000	1.000
97	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(5), NFKB1(6), NFKBIA(4), PLCB1(52), PRKCA(10), RELA(3)	6638404	80	70	79	22	7	38	12	8	15	0	0.334	1.000	1.000
98	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(8), ALOX15(5), ALOX15B(6), ALOX5(10), ALOX5AP(2), DPEP1(5), GGT1(1), LTA4H(3), PLA2G2A(5), PLA2G6(3), PTGDS(4), PTGIS(12), PTGS1(18), PTGS2(12), TBXAS1(11)	11922131	105	86	102	23	18	37	22	13	15	0	0.0217	1.000	1.000
99	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(7), FOS(3), HRAS(2), JUN(3), MAP2K1(10), MAPK1(2), MAPK3(3), MYC(4), NFKB1(6), NFKBIA(4), PLCB1(52), PRKCA(10), RAF1(6), RELA(3), TNF(2)	12532437	117	99	112	28	14	49	20	13	21	0	0.0664	1.000	1.000
100	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM1(3), CALM2(1), CAMK1(1), CAMK1G(2), CAMK2A(3), CAMK2B(16), CAMK2D(7), CAMK4(16), CAMKK1(4), CAMKK2(3), CREB1(2), SYT1(6)	9210287	64	59	64	16	5	26	11	7	15	0	0.227	1.000	1.000
101	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	186	ACTB(10), ACTG1(6), ACTN1(7), ACTN2(43), ACTN4(6), AKT1(3), AKT2(7), AKT3(7), ARHGAP5(17), BCAR1(3), BCL2(5), BIRC2(2), BIRC3(4), CAPN2(5), CAV1(1), CAV2(1), CAV3(3), CCND1(3), CCND2(4), CCND3(1), CDC42(1), CHAD(1), COL11A2(21), COL1A1(21), COL1A2(41), COL2A1(24), COL3A1(67), COL4A1(36), COL4A2(40), COL4A4(22), COL4A6(28), COL5A1(42), COL5A2(57), COL5A3(29), COL6A1(11), COL6A2(21), COL6A3(80), COL6A6(45), COMP(4), CRK(1), CRKL(4), DIAPH1(3), DOCK1(15), EGF(13), ELK1(3), ERBB2(12), FARP2(7), FIGF(4), FLNA(31), FLNB(16), FLNC(55), FLT1(31), FN1(25), FYN(8), GRB2(6), GSK3B(4), HGF(54), HRAS(2), IBSP(9), IGF1(4), IGF1R(8), ILK(1), ITGA1(14), ITGA10(16), ITGA11(12), ITGA2(25), ITGA2B(12), ITGA3(8), ITGA4(38), ITGA5(11), ITGA6(12), ITGA7(13), ITGA8(59), ITGA9(6), ITGAV(14), ITGB1(6), ITGB3(13), ITGB4(10), ITGB5(4), ITGB6(11), ITGB7(2), ITGB8(15), JUN(3), KDR(56), LAMA1(63), LAMA2(81), LAMA3(36), LAMA4(40), LAMA5(33), LAMB1(40), LAMB2(21), LAMB3(19), LAMB4(52), LAMC1(27), LAMC2(11), LAMC3(25), MAP2K1(10), MAPK1(2), MAPK10(6), MAPK3(3), MAPK8(2), MAPK9(8), MET(22), MYL2(8), MYL5(2), MYL7(4), MYL9(3), MYLK(26), MYLK2(9), PAK1(9), PAK2(3), PAK3(16), PAK4(6), PAK6(2), PAK7(37), PARVA(3), PARVB(3), PARVG(8), PDGFA(5), PDGFB(2), PDGFC(3), PDGFD(9), PDGFRA(41), PDGFRB(18), PDPK1(3), PGF(1), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PIP5K1C(4), PPP1CA(2), PPP1CB(4), PPP1CC(1), PPP1R12A(8), PRKCA(10), PRKCG(20), PTEN(11), PTK2(6), PXN(1), RAC2(2), RAF1(6), RAP1A(1), RAP1B(2), RAPGEF1(7), RELN(104), RHOA(4), ROCK1(19), ROCK2(9), SHC1(6), SHC2(5), SHC3(8), SHC4(7), SOS1(17), SOS2(13), SPP1(5), SRC(2), THBS1(8), THBS2(35), THBS3(5), THBS4(8), TLN1(15), TLN2(30), TNC(26), TNN(87), TNXB(32), VASP(2), VAV1(8), VAV2(8), VAV3(32), VCL(8), VEGFA(1), VEGFB(2), VEGFC(21), VTN(4), VWF(32), ZYX(6)	284735848	2859	469	2822	878	360	1224	522	231	511	11	0.0981	1.000	1.000
102	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	166	ADCY1(26), ADCY2(51), ADCY3(7), ADCY4(12), ADCY7(13), ADCY8(48), ADCY9(12), ADORA2A(3), ADORA2B(1), ADRA1A(7), ADRA1B(8), ADRA1D(8), ADRB1(1), ADRB2(4), ADRB3(6), AGTR1(9), ATP2A1(9), ATP2A2(12), ATP2A3(7), ATP2B1(10), ATP2B2(28), ATP2B3(28), ATP2B4(13), AVPR1A(14), AVPR1B(7), BDKRB1(1), BDKRB2(3), BST1(3), CACNA1A(32), CACNA1B(39), CACNA1C(61), CACNA1D(21), CACNA1E(111), CACNA1F(30), CACNA1G(27), CACNA1H(21), CACNA1I(31), CACNA1S(23), CALM1(3), CALM2(1), CALML3(3), CALML6(1), CAMK2A(3), CAMK2B(16), CAMK2D(7), CAMK4(16), CCKAR(14), CCKBR(24), CD38(4), CHRM1(5), CHRM2(39), CHRM3(27), CHRM5(6), CHRNA7(3), CYSLTR1(5), CYSLTR2(12), DRD1(13), EDNRA(3), EDNRB(16), ERBB2(12), ERBB3(11), ERBB4(51), F2R(10), GNA11(4), GNA14(2), GNA15(1), GNAL(5), GNAQ(5), GNAS(29), GRIN1(9), GRIN2A(61), GRIN2C(8), GRIN2D(9), GRM1(48), GRM5(40), GRPR(7), HRH1(5), HRH2(17), HTR2A(6), HTR2B(5), HTR2C(8), HTR4(6), HTR5A(21), HTR6(10), HTR7(11), ITPKA(2), ITPKB(7), ITPR1(20), ITPR2(40), ITPR3(21), LHCGR(14), MYLK(26), MYLK2(9), NOS1(29), NOS3(12), NTSR1(10), OXTR(4), P2RX1(6), P2RX2(6), P2RX3(4), P2RX5(12), P2RX7(6), PDE1A(17), PDE1B(13), PDE1C(28), PDGFRA(41), PDGFRB(18), PHKA1(16), PHKA2(14), PHKB(10), PHKG1(5), PHKG2(4), PLCB1(52), PLCB2(12), PLCB3(9), PLCB4(35), PLCD1(4), PLCD3(2), PLCD4(7), PLCE1(28), PLCG1(7), PLCG2(18), PLCZ1(8), PLN(1), PPID(2), PPP3CB(3), PPP3CC(3), PPP3R1(5), PRKACA(3), PRKACB(9), PRKACG(4), PRKCA(10), PRKCG(20), PRKX(3), PTAFR(5), PTGER3(9), PTGFR(12), PTK2B(14), RYR1(111), RYR2(359), RYR3(124), SLC25A5(3), SLC25A6(5), SLC8A1(55), SLC8A2(10), SLC8A3(28), SPHK2(4), TACR1(4), TACR2(2), TACR3(15), TBXA2R(1), TNNC1(1), TNNC2(2), TRHR(14), TRPC1(10), VDAC1(2), VDAC2(2), VDAC3(1)	212109110	2801	462	2757	931	432	1147	573	235	396	18	0.0212	1.000	1.000
103	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	233	ADCYAP1R1(17), ADORA1(9), ADORA2A(3), ADORA2B(1), ADORA3(4), ADRA1A(7), ADRA1B(8), ADRA2A(3), ADRA2B(4), ADRA2C(3), ADRB1(1), ADRB2(4), ADRB3(6), AGTR1(9), AGTR2(6), AVPR1A(14), AVPR1B(7), AVPR2(7), BDKRB1(1), BDKRB2(3), BRS3(8), C3AR1(11), C5AR1(7), CALCR(27), CALCRL(18), CCKAR(14), CCKBR(24), CGA(2), CHRM1(5), CHRM2(39), CHRM3(27), CHRM4(8), CHRM5(6), CNR1(15), CNR2(3), CRHR1(7), CTSG(12), CYSLTR1(5), CYSLTR2(12), DRD1(13), DRD3(19), DRD4(2), DRD5(26), EDNRA(3), EDNRB(16), F2(9), F2R(10), F2RL1(2), F2RL2(12), F2RL3(2), FPR1(10), FSHB(4), FSHR(37), GABBR1(8), GABBR2(13), GABRA1(20), GABRA2(31), GABRA3(15), GABRA4(39), GABRA5(27), GABRA6(28), GABRB1(21), GABRB2(10), GABRB3(37), GABRD(8), GABRE(6), GABRG1(34), GABRG3(28), GABRP(6), GABRQ(23), GABRR1(11), GABRR2(10), GALR1(8), GALR2(3), GALR3(1), GH1(7), GH2(7), GHR(19), GHRHR(5), GHSR(5), GIPR(3), GLP1R(11), GLP2R(17), GLRA1(10), GLRA2(22), GLRA3(9), GLRB(9), GNRHR(5), GPR156(16), GPR35(8), GPR50(21), GPR63(10), GPR83(12), GRIA1(18), GRIA2(28), GRIA3(24), GRIA4(25), GRID1(30), GRID2(54), GRIK1(31), GRIK2(41), GRIK3(22), GRIK4(25), GRIK5(15), GRIN1(9), GRIN2A(61), GRIN2B(53), GRIN2C(8), GRIN2D(9), GRIN3A(38), GRIN3B(6), GRM1(48), GRM2(7), GRM3(19), GRM4(21), GRM5(40), GRM6(17), GRM7(43), GRM8(52), GRPR(7), GZMA(8), HCRTR1(4), HCRTR2(24), HRH1(5), HRH2(17), HRH3(7), HRH4(5), HTR1A(24), HTR1B(7), HTR1D(5), HTR1E(23), HTR1F(10), HTR2A(6), HTR2B(5), HTR2C(8), HTR4(6), HTR5A(21), HTR6(10), HTR7(11), LEP(4), LEPR(26), LHB(3), LHCGR(14), LTB4R(5), MAS1(5), MC1R(2), MC2R(12), MC3R(16), MC4R(3), MC5R(22), MCHR1(4), MCHR2(16), MLNR(2), MTNR1A(15), MTNR1B(13), NMBR(8), NMUR1(9), NMUR2(23), NPBWR1(5), NPBWR2(8), NPFFR1(2), NPY1R(17), NPY2R(20), NPY5R(22), NR3C1(8), NTSR1(10), NTSR2(6), OPRD1(2), OPRK1(12), OPRL1(14), OPRM1(12), OXTR(4), P2RX1(6), P2RX2(6), P2RX3(4), P2RX5(12), P2RX7(6), P2RY1(4), P2RY10(23), P2RY11(2), P2RY13(1), P2RY14(2), P2RY2(3), P2RY4(4), P2RY6(2), P2RY8(9), PARD3(15), PRL(3), PRLHR(9), PRLR(18), PRSS1(25), PRSS3(1), PTAFR(5), PTGDR(8), PTGER2(4), PTGER3(9), PTGER4(7), PTGFR(12), PTGIR(6), PTH2R(15), RXFP1(20), RXFP2(8), SCTR(5), SSTR1(9), SSTR2(4), SSTR3(8), SSTR4(15), SSTR5(6), TAAR1(5), TAAR2(9), TAAR5(11), TAAR6(15), TAAR8(9), TACR1(4), TACR2(2), TACR3(15), TBXA2R(1), THRA(5), THRB(4), TRHR(14), TRPV1(5), TSHB(5), TSHR(22), UTS2R(4), VIPR1(2), VIPR2(3)	175095851	2847	455	2813	1011	385	1244	586	246	378	8	0.113	1.000	1.000
104	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	242	ACVR1B(11), ACVR1C(11), AKT1(3), AKT2(7), AKT3(7), ARRB1(2), ARRB2(4), ATF2(10), ATF4(2), BDNF(1), CACNA1A(32), CACNA1B(39), CACNA1C(61), CACNA1D(21), CACNA1E(111), CACNA1F(30), CACNA1G(27), CACNA1H(21), CACNA1I(31), CACNA1S(23), CACNA2D1(46), CACNA2D3(24), CACNA2D4(25), CACNB1(5), CACNB2(23), CACNB3(1), CACNB4(4), CACNG1(2), CACNG2(6), CACNG3(18), CACNG4(5), CACNG5(8), CACNG6(11), CACNG7(9), CACNG8(5), CASP3(5), CD14(1), CDC25B(1), CDC42(1), CHUK(7), CRK(1), CRKL(4), DAXX(8), DDIT3(2), DUSP1(1), DUSP10(11), DUSP14(2), DUSP16(3), DUSP2(2), DUSP3(4), DUSP4(2), DUSP5(3), DUSP6(4), DUSP7(3), DUSP8(2), DUSP9(6), EGF(13), ELK1(3), ELK4(6), FAS(4), FASLG(10), FGF1(2), FGF10(10), FGF12(7), FGF13(10), FGF14(11), FGF16(1), FGF17(1), FGF18(6), FGF19(2), FGF20(1), FGF21(3), FGF22(2), FGF23(12), FGF3(2), FGF4(2), FGF5(4), FGF6(9), FGF7(3), FGF8(2), FGF9(3), FGFR1(4), FGFR2(12), FGFR3(2), FGFR4(10), FLNA(31), FLNB(16), FLNC(55), FOS(3), GADD45A(2), GADD45B(1), GADD45G(1), GNA12(1), GNG12(3), GRB2(6), HRAS(2), IKBKB(9), IL1A(4), IL1B(1), IL1R1(2), IL1R2(5), JUN(3), JUND(1), MAP2K1(10), MAP2K2(1), MAP2K3(13), MAP2K4(8), MAP2K5(4), MAP2K6(5), MAP2K7(7), MAP3K1(7), MAP3K10(4), MAP3K12(10), MAP3K13(12), MAP3K2(6), MAP3K3(10), MAP3K4(21), MAP3K5(14), MAP3K6(4), MAP3K7(10), MAP3K8(4), MAP4K1(12), MAP4K2(4), MAP4K3(12), MAP4K4(8), MAPK1(2), MAPK10(6), MAPK12(2), MAPK13(1), MAPK14(4), MAPK3(3), MAPK7(7), MAPK8(2), MAPK8IP1(4), MAPK8IP2(2), MAPK8IP3(7), MAPK9(8), MAPKAPK2(2), MAPKAPK3(3), MAPKAPK5(5), MAPT(15), MAX(8), MEF2C(6), MKNK1(4), MKNK2(2), MOS(9), MRAS(1), MYC(4), NF1(65), NFATC2(15), NFATC4(11), NFKB1(6), NFKB2(5), NLK(3), NR4A1(5), NRAS(4), NTF3(11), NTRK1(14), NTRK2(21), PAK1(9), PAK2(3), PDGFA(5), PDGFB(2), PDGFRA(41), PDGFRB(18), PLA2G12A(4), PLA2G12B(3), PLA2G1B(2), PLA2G2A(5), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(6), PLA2G4A(21), PLA2G6(3), PPM1A(6), PPM1B(9), PPP3CB(3), PPP3CC(3), PPP3R1(5), PPP5C(2), PRKACA(3), PRKACB(9), PRKACG(4), PRKCA(10), PRKCG(20), PRKX(3), PTPN5(12), PTPN7(1), PTPRR(16), RAC2(2), RAF1(6), RAP1A(1), RAP1B(2), RAPGEF2(24), RASA1(11), RASA2(8), RASGRF1(11), RASGRF2(22), RASGRP1(3), RASGRP2(7), RASGRP3(11), RASGRP4(9), RPS6KA1(6), RPS6KA2(8), RPS6KA3(6), RPS6KA4(4), RPS6KA5(10), RPS6KA6(18), RRAS(1), RRAS2(3), SOS1(17), SOS2(13), SRF(1), STK3(4), STK4(6), STMN1(2), TAOK1(8), TAOK2(11), TAOK3(9), TGFB1(3), TGFB2(10), TGFBR1(7), TGFBR2(7), TNF(2), TRAF2(5), TRAF6(6), ZAK(7)	222088450	2000	454	1979	647	281	754	405	198	353	9	0.286	1.000	1.000
105	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	123	ABL1(9), ABLIM1(4), ABLIM2(4), ABLIM3(18), ARHGEF12(24), CDC42(1), CDK5(3), CFL2(3), CXCL12(3), CXCR4(6), DCC(41), DPYSL2(3), DPYSL5(10), EFNA2(1), EFNA3(2), EFNB1(2), EFNB2(4), EFNB3(1), EPHA1(9), EPHA2(10), EPHA3(56), EPHA4(18), EPHA5(78), EPHA8(21), EPHB1(44), EPHB2(10), EPHB3(14), EPHB4(10), EPHB6(53), FES(1), FYN(8), GNAI1(10), GNAI3(2), GSK3B(4), HRAS(2), ITGB1(6), L1CAM(42), LIMK1(3), LIMK2(3), LRRC4C(53), MAPK1(2), MAPK3(3), MET(22), NCK1(5), NCK2(6), NFAT5(13), NFATC1(9), NFATC2(15), NFATC3(15), NFATC4(11), NGEF(12), NRAS(4), NRP1(9), NTN1(1), NTN4(6), NTNG1(33), PAK1(9), PAK2(3), PAK3(16), PAK4(6), PAK6(2), PAK7(37), PLXNA1(16), PLXNA2(30), PLXNA3(20), PLXNB1(12), PLXNB2(21), PLXNB3(15), PLXNC1(11), PPP3CB(3), PPP3CC(3), PPP3R1(5), PTK2(6), RAC2(2), RASA1(11), RGS3(11), RHOA(4), RHOD(2), ROBO1(31), ROBO2(54), ROBO3(19), ROCK1(19), ROCK2(9), SEMA3A(26), SEMA3C(15), SEMA3D(33), SEMA3E(15), SEMA3F(7), SEMA3G(6), SEMA4A(5), SEMA4C(7), SEMA4D(8), SEMA4F(12), SEMA4G(3), SEMA5A(59), SEMA5B(30), SEMA6A(20), SEMA6B(12), SEMA6C(10), SEMA6D(40), SEMA7A(9), SLIT1(21), SLIT2(61), SLIT3(41), SRGAP1(20), SRGAP2(7), SRGAP3(24), UNC5A(18), UNC5B(19), UNC5C(22), UNC5D(45)	152345381	1734	439	1699	536	251	705	314	152	306	6	0.0207	1.000	1.000
106	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	199	ABI2(4), ACTN1(7), ACTN2(43), ACTN4(6), APC(33), APC2(8), ARAF(5), ARHGEF1(5), ARHGEF12(24), ARHGEF4(11), ARHGEF6(21), ARHGEF7(6), ARPC1A(3), ARPC1B(4), ARPC2(3), ARPC3(2), ARPC5(1), BAIAP2(3), BCAR1(3), BDKRB1(1), BDKRB2(3), CD14(1), CDC42(1), CFL2(3), CHRM1(5), CHRM2(39), CHRM3(27), CHRM4(8), CHRM5(6), CRK(1), CRKL(4), CSK(2), CYFIP1(12), CYFIP2(11), DIAPH1(3), DIAPH2(18), DIAPH3(16), DOCK1(15), EGF(13), EZR(3), F2(9), F2R(10), FGD1(13), FGD3(8), FGF1(2), FGF10(10), FGF12(7), FGF13(10), FGF14(11), FGF16(1), FGF17(1), FGF18(6), FGF19(2), FGF20(1), FGF21(3), FGF22(2), FGF23(12), FGF3(2), FGF4(2), FGF5(4), FGF6(9), FGF7(3), FGF8(2), FGF9(3), FGFR1(4), FGFR2(12), FGFR3(2), FGFR4(10), FN1(25), GIT1(3), GNA12(1), GNA13(6), GNG12(3), GSN(4), HRAS(2), IQGAP1(8), IQGAP2(31), IQGAP3(16), ITGA1(14), ITGA10(16), ITGA11(12), ITGA2(25), ITGA2B(12), ITGA3(8), ITGA4(38), ITGA5(11), ITGA6(12), ITGA7(13), ITGA8(59), ITGA9(6), ITGAD(38), ITGAE(20), ITGAL(26), ITGAM(24), ITGAV(14), ITGAX(52), ITGB1(6), ITGB2(8), ITGB3(13), ITGB4(10), ITGB5(4), ITGB6(11), ITGB7(2), ITGB8(15), LIMK1(3), LIMK2(3), MAP2K1(10), MAP2K2(1), MAPK1(2), MAPK3(3), MOS(9), MRAS(1), MSN(8), MYH10(14), MYH14(9), MYH9(19), MYL2(8), MYL5(2), MYL7(4), MYL9(3), MYLK(26), MYLK2(9), NCKAP1(11), NCKAP1L(24), NRAS(4), PAK1(9), PAK2(3), PAK3(16), PAK4(6), PAK6(2), PAK7(37), PDGFA(5), PDGFB(2), PDGFRA(41), PDGFRB(18), PFN1(1), PFN2(1), PFN4(2), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PIP4K2A(7), PIP4K2B(3), PIP4K2C(7), PIP5K1A(6), PIP5K1B(6), PIP5K1C(4), PPP1CA(2), PPP1CB(4), PPP1CC(1), PPP1R12A(8), PPP1R12B(15), PTK2(6), PXN(1), RAC2(2), RAF1(6), RDX(2), RHOA(4), ROCK1(19), ROCK2(9), RRAS(1), RRAS2(3), SCIN(6), SLC9A1(6), SOS1(17), SOS2(13), SSH1(9), SSH2(9), SSH3(9), TIAM1(59), TIAM2(22), VAV1(8), VAV2(8), VAV3(32), VCL(8), WAS(8), WASF1(10), WASF2(3), WASL(7)	215419490	1857	439	1828	580	237	722	396	165	331	6	0.200	1.000	1.000
107	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	134	ACTB(10), ACTG1(6), CHAD(1), COL11A2(21), COL17A1(16), COL1A1(21), COL1A2(41), COL2A1(24), COL3A1(67), COL4A1(36), COL4A2(40), COL4A4(22), COL4A6(28), COL5A1(42), COL5A2(57), COL5A3(29), COL6A1(11), COL6A2(21), COL6A3(80), COL6A6(45), COMP(4), DES(4), DSC1(16), DSC2(24), DSC3(21), DSG1(29), DSG2(12), DSG3(37), DSG4(28), FN1(25), GJA1(11), GJA10(15), GJA3(3), GJA4(6), GJA5(7), GJA8(18), GJA9(12), GJB1(3), GJB2(1), GJB3(2), GJB4(10), GJB5(6), GJB6(2), GJB7(6), GJC1(8), GJC2(5), GJC3(4), GJD2(6), GJD4(3), IBSP(9), INA(4), ITGA6(12), ITGB4(10), KRT1(11), KRT10(6), KRT12(8), KRT13(5), KRT14(11), KRT15(4), KRT16(8), KRT17(9), KRT19(6), KRT2(11), KRT20(5), KRT23(7), KRT24(9), KRT25(11), KRT27(3), KRT28(11), KRT3(9), KRT31(14), KRT32(3), KRT33A(7), KRT33B(7), KRT34(15), KRT35(11), KRT36(9), KRT37(14), KRT38(15), KRT39(5), KRT4(9), KRT40(7), KRT5(14), KRT6A(14), KRT6B(19), KRT6C(5), KRT7(9), KRT71(12), KRT72(14), KRT73(10), KRT74(11), KRT75(11), KRT76(4), KRT77(6), KRT78(6), KRT79(12), KRT8(3), KRT81(2), KRT82(12), KRT83(9), KRT84(5), KRT85(5), KRT86(1), KRT9(5), LAMA1(63), LAMA2(81), LAMA3(36), LAMA4(40), LAMA5(33), LAMB1(40), LAMB2(21), LAMB3(19), LAMB4(52), LAMC1(27), LAMC2(11), LAMC3(25), LMNA(2), LMNB1(5), LMNB2(5), NES(33), PRPH(1), RELN(104), SPP1(5), THBS1(8), THBS2(35), THBS3(5), THBS4(8), TNC(26), TNN(87), TNXB(32), VIM(5), VTN(4), VWF(32)	193998247	2265	437	2245	741	303	987	422	154	391	8	0.433	1.000	1.000
108	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ADCY1(26), ADCY2(51), ADCY3(7), ADCY4(12), ADCY5(27), ADCY6(10), ADCY7(13), ADCY8(48), ADCY9(12), ADRA1A(7), ADRA1B(8), ADRA1D(8), ADRB1(1), ADRB2(4), ADRB3(6), ANXA6(8), ARRB1(2), ARRB2(4), ATP1A4(19), ATP1B1(6), ATP1B2(1), ATP1B3(2), ATP2A2(12), ATP2A3(7), ATP2B1(10), ATP2B2(28), ATP2B3(28), CACNA1A(32), CACNA1B(39), CACNA1C(61), CACNA1D(21), CACNA1E(111), CACNA1S(23), CACNB1(5), CACNB3(1), CALM1(3), CALM2(1), CALR(2), CAMK1(1), CAMK2A(3), CAMK2B(16), CAMK2D(7), CAMK4(16), CASQ1(6), CASQ2(5), CHRM1(5), CHRM2(39), CHRM3(27), CHRM4(8), CHRM5(6), FXYD2(1), GJA1(11), GJA4(6), GJA5(7), GJB1(3), GJB2(1), GJB3(2), GJB4(10), GJB5(6), GJB6(2), GNA11(4), GNAI3(2), GNAO1(7), GNAQ(5), GNAZ(5), GNB1(2), GNB3(5), GNB4(3), GNB5(7), GNG12(3), GNG13(5), GNG2(6), GNG3(1), GNG4(1), GNG7(1), GNGT1(6), GRK4(5), GRK5(10), GRK6(1), ITPR1(20), ITPR2(40), ITPR3(21), KCNB1(28), KCNJ3(36), KCNJ5(10), MIB1(12), NME7(4), PEA15(1), PKIA(1), PKIB(1), PKIG(1), PLCB3(9), PLN(1), PRKACA(3), PRKACB(9), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PRKCA(10), PRKCD(7), PRKCE(5), PRKCG(20), PRKCH(6), PRKCQ(12), PRKCZ(4), PRKD1(31), RGS1(14), RGS10(3), RGS11(3), RGS14(4), RGS16(3), RGS18(14), RGS19(2), RGS2(5), RGS20(8), RGS3(11), RGS4(6), RGS5(7), RGS6(14), RGS9(16), RYR1(111), RYR2(359), RYR3(124), SFN(1), SLC8A1(55), SLC8A3(28), USP5(8), YWHAB(1), YWHAH(1), YWHAQ(4)	149525202	2038	429	2008	677	298	851	420	177	276	16	0.0825	1.000	1.000
109	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	83	AGRN(16), CD36(4), CD44(7), CD47(6), CHAD(1), COL11A2(21), COL1A1(21), COL1A2(41), COL2A1(24), COL3A1(67), COL4A1(36), COL4A2(40), COL4A4(22), COL4A6(28), COL5A1(42), COL5A2(57), COL5A3(29), COL6A1(11), COL6A2(21), COL6A3(80), COL6A6(45), DAG1(3), FN1(25), FNDC1(33), FNDC3A(9), FNDC4(1), FNDC5(1), GP5(8), GP6(6), HMMR(6), HSPG2(33), IBSP(9), ITGA1(14), ITGA10(16), ITGA11(12), ITGA2(25), ITGA2B(12), ITGA3(8), ITGA4(38), ITGA5(11), ITGA6(12), ITGA7(13), ITGA8(59), ITGA9(6), ITGAV(14), ITGB1(6), ITGB3(13), ITGB4(10), ITGB5(4), ITGB6(11), ITGB7(2), ITGB8(15), LAMA1(63), LAMA2(81), LAMA3(36), LAMA4(40), LAMA5(33), LAMB1(40), LAMB2(21), LAMB3(19), LAMB4(52), LAMC1(27), LAMC2(11), LAMC3(25), RELN(104), SDC1(4), SDC2(1), SDC3(3), SDC4(2), SPP1(5), SV2A(17), SV2B(14), SV2C(20), THBS1(8), THBS2(35), THBS3(5), THBS4(8), TNC(26), TNN(87), TNXB(32), VTN(4), VWF(32)	173606026	1909	423	1896	582	234	850	363	115	338	9	0.140	1.000	1.000
110	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	129	ACTB(10), ACTG1(6), ACTN1(7), ACTN2(43), ACTN4(6), AKT1(3), AKT2(7), AKT3(7), AMOTL1(11), ASH1L(33), CASK(8), CDC42(1), CDK4(3), CGN(12), CLDN1(1), CLDN10(7), CLDN11(4), CLDN14(6), CLDN15(1), CLDN16(8), CLDN17(10), CLDN18(5), CLDN2(5), CLDN20(2), CLDN22(1), CLDN4(3), CLDN6(2), CLDN8(6), CLDN9(2), CSNK2A1(5), CSNK2A2(2), CTNNA1(9), CTNNA2(65), CTNNA3(22), CTTN(6), EPB41(2), EPB41L1(10), EPB41L2(16), EPB41L3(31), EXOC3(3), EXOC4(16), F11R(3), GNAI1(10), GNAI3(2), HCLS1(17), HRAS(2), IGSF5(6), INADL(20), JAM2(9), JAM3(4), LLGL1(6), LLGL2(9), MAGI1(21), MAGI2(33), MAGI3(10), MLLT4(12), MPDZ(20), MPP5(2), MRAS(1), MYH1(70), MYH10(14), MYH11(29), MYH13(47), MYH14(9), MYH15(31), MYH2(77), MYH3(37), MYH4(53), MYH6(42), MYH7(59), MYH7B(10), MYH8(73), MYH9(19), MYL2(8), MYL5(2), MYL7(4), MYL9(3), NRAS(4), OCLN(1), PARD3(15), PARD6A(1), PARD6B(4), PARD6G(2), PPM1J(2), PPP2CA(1), PPP2CB(3), PPP2R1A(10), PPP2R1B(5), PPP2R2A(8), PPP2R2B(12), PPP2R2C(5), PPP2R3A(2), PPP2R3B(6), PPP2R4(1), PRKCA(10), PRKCD(7), PRKCE(5), PRKCG(20), PRKCH(6), PRKCI(11), PRKCQ(12), PRKCZ(4), PTEN(11), RAB13(1), RAB3B(1), RHOA(4), RRAS(1), RRAS2(3), SPTAN1(21), SRC(2), SYMPK(16), TJAP1(4), TJP1(15), TJP2(6), TJP3(6), VAPA(2), YES1(3), ZAK(7)	153848798	1441	412	1426	431	194	567	308	125	243	4	0.0764	1.000	1.000
111	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	137	ACTA1(9), ACTA2(1), ADCY1(26), ADCY2(51), ADCY3(7), ADCY4(12), ADCY5(27), ADCY6(10), ADCY7(13), ADCY8(48), ADCY9(12), ADM(1), ARRB1(2), ARRB2(4), ATF1(1), ATF2(10), ATF4(2), ATF5(2), ATP2A2(12), ATP2A3(7), CACNB3(1), CALCA(7), CALM1(3), CALM2(1), CAMK2A(3), CAMK2B(16), CAMK2D(7), CNN1(5), CORIN(25), CRH(3), CRHR1(7), DGKZ(5), ETS2(6), FOS(3), GABPA(6), GABPB2(1), GBA2(5), GJA1(11), GNAQ(5), GNB1(2), GNB3(5), GNB4(3), GNB5(7), GNG12(3), GNG13(5), GNG2(6), GNG3(1), GNG4(1), GNG7(1), GNGT1(6), GRK4(5), GRK5(10), GRK6(1), GUCA2B(2), GUCY1A3(16), IGFBP1(6), IGFBP2(4), IGFBP3(4), IGFBP4(1), IGFBP6(1), IL1B(1), IL6(2), ITPR1(20), ITPR2(40), ITPR3(21), JUN(3), MIB1(12), MYL2(8), MYL4(2), MYLK2(9), NFKB1(6), NOS1(29), NOS3(12), OXT(2), OXTR(4), PDE4B(14), PDE4D(5), PKIA(1), PKIB(1), PKIG(1), PLCB3(9), PLCD1(4), PLCG1(7), PLCG2(18), PRKACA(3), PRKACB(9), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PRKCA(10), PRKCD(7), PRKCE(5), PRKCH(6), PRKCQ(12), PRKCZ(4), PRKD1(31), RAMP1(1), RAMP2(4), RAMP3(3), RGS1(14), RGS10(3), RGS11(3), RGS14(4), RGS16(3), RGS18(14), RGS19(2), RGS2(5), RGS20(8), RGS3(11), RGS4(6), RGS5(7), RGS6(14), RGS9(16), RYR1(111), RYR2(359), RYR3(124), SFN(1), SLC8A1(55), SP1(6), TNXB(32), USP5(8), YWHAB(1), YWHAH(1), YWHAQ(4)	137951115	1616	405	1594	543	222	668	336	146	231	13	0.348	1.000	1.000
112	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	245	ACVR1(7), ACVR1B(11), ACVR2A(5), ACVR2B(4), AMHR2(6), BMP2(1), BMP7(12), BMPR1A(4), BMPR1B(7), BMPR2(10), CCL1(4), CCL11(2), CCL13(3), CCL14(3), CCL15(5), CCL16(4), CCL17(3), CCL18(2), CCL19(1), CCL2(2), CCL20(3), CCL21(2), CCL22(1), CCL23(3), CCL24(1), CCL25(2), CCL28(6), CCL4(2), CCL7(5), CCL8(1), CCR1(3), CCR2(6), CCR3(4), CCR4(3), CCR5(4), CCR6(9), CCR8(6), CD27(1), CD40(3), CD40LG(9), CD70(1), CNTF(6), CNTFR(5), CRLF2(9), CSF1(1), CSF1R(18), CSF2RA(8), CSF2RB(14), CSF3R(6), CX3CL1(5), CX3CR1(11), CXCL1(1), CXCL10(1), CXCL11(1), CXCL12(3), CXCL14(1), CXCL2(1), CXCL6(3), CXCL9(4), CXCR3(3), CXCR4(6), CXCR6(2), EDA(4), EDA2R(9), EDAR(8), EGF(13), EPO(6), EPOR(2), FAS(4), FASLG(10), FLT1(31), FLT3(24), FLT3LG(2), FLT4(20), GDF5(12), GH1(7), GH2(7), GHR(19), HGF(54), IFNA1(2), IFNA10(7), IFNA14(4), IFNA16(8), IFNA17(5), IFNA2(5), IFNA21(3), IFNA4(4), IFNA5(5), IFNA7(6), IFNA8(7), IFNAR1(4), IFNAR2(7), IFNB1(7), IFNG(7), IFNGR1(7), IFNGR2(4), IFNK(1), IFNW1(2), IL10(2), IL10RA(6), IL10RB(6), IL11RA(1), IL12A(2), IL12B(3), IL12RB1(5), IL12RB2(15), IL13(2), IL13RA1(3), IL15(6), IL15RA(2), IL17A(12), IL17B(2), IL17RA(4), IL18R1(12), IL18RAP(22), IL19(2), IL1A(4), IL1B(1), IL1R1(2), IL1R2(5), IL1RAP(4), IL2(7), IL20(2), IL20RA(5), IL21(2), IL21R(14), IL22(4), IL22RA1(7), IL22RA2(6), IL23R(6), IL24(3), IL25(2), IL26(3), IL2RA(6), IL2RB(7), IL2RG(5), IL3(4), IL3RA(8), IL4(1), IL4R(10), IL5(2), IL5RA(9), IL6(2), IL6R(8), IL6ST(3), IL7(2), IL7R(21), IL9(1), IL9R(16), INHBB(4), INHBC(4), INHBE(5), KDR(56), KIT(12), KITLG(6), LEP(4), LEPR(26), LIF(3), LIFR(14), LTA(3), LTB(4), LTBR(1), MET(22), MPL(5), NGFR(5), OSM(5), OSMR(7), PDGFB(2), PDGFC(3), PDGFRA(41), PDGFRB(18), PF4(1), PF4V1(2), PLEKHO2(3), PPBP(2), PRL(3), PRLR(18), TGFB1(3), TGFB2(10), TGFBR1(7), TGFBR2(7), TNF(2), TNFRSF10B(3), TNFRSF10C(1), TNFRSF10D(2), TNFRSF11A(9), TNFRSF11B(3), TNFRSF12A(2), TNFRSF13B(3), TNFRSF13C(2), TNFRSF14(1), TNFRSF18(2), TNFRSF19(5), TNFRSF1B(2), TNFRSF21(3), TNFRSF25(2), TNFRSF4(4), TNFRSF6B(1), TNFRSF8(11), TNFRSF9(7), TNFSF10(3), TNFSF11(5), TNFSF12(1), TNFSF13B(1), TNFSF14(2), TNFSF15(3), TNFSF18(5), TNFSF4(2), TNFSF8(1), TNFSF9(3), TPO(33), VEGFA(1), VEGFB(2), VEGFC(21), XCL1(7), XCL2(5), XCR1(6)	138869143	1368	400	1351	413	140	572	272	148	234	2	0.108	1.000	1.000
113	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	128	ALCAM(6), CADM1(7), CADM3(15), CD2(6), CD22(16), CD226(14), CD274(3), CD276(2), CD28(4), CD34(13), CD4(8), CD40(3), CD40LG(9), CD58(1), CD6(13), CD80(3), CD86(11), CD8A(4), CD8B(5), CD99(3), CDH1(6), CDH15(9), CDH2(35), CDH3(7), CDH4(23), CDH5(13), CLDN1(1), CLDN10(7), CLDN11(4), CLDN14(6), CLDN15(1), CLDN16(8), CLDN17(10), CLDN18(5), CLDN2(5), CLDN20(2), CLDN22(1), CLDN4(3), CLDN6(2), CLDN8(6), CLDN9(2), CNTN1(36), CNTN2(18), CNTNAP1(11), CNTNAP2(88), CTLA4(3), ESAM(2), F11R(3), GLG1(17), HLA-A(8), HLA-B(4), HLA-C(5), HLA-DMA(4), HLA-DMB(3), HLA-DOA(2), HLA-DPA1(1), HLA-DQA2(3), HLA-DQB1(4), HLA-DRA(3), HLA-DRB1(5), HLA-E(2), HLA-G(5), ICAM1(2), ICAM2(2), ICAM3(2), ICOS(5), ICOSLG(3), ITGA4(38), ITGA6(12), ITGA8(59), ITGA9(6), ITGAL(26), ITGAM(24), ITGAV(14), ITGB1(6), ITGB2(8), ITGB7(2), ITGB8(15), JAM2(9), JAM3(4), L1CAM(42), MADCAM1(2), MAG(7), MPZ(2), MPZL1(3), NCAM1(30), NCAM2(28), NEGR1(14), NEO1(12), NFASC(46), NLGN1(34), NLGN2(10), NLGN3(14), NRCAM(35), NRXN2(25), NRXN3(49), OCLN(1), PDCD1(4), PDCD1LG2(4), PTPRC(41), PTPRF(15), PTPRM(14), PVRL1(16), PVRL3(7), SDC1(4), SDC2(1), SDC3(3), SDC4(2), SELL(9), SELP(29), SELPLG(2), SIGLEC1(18), SPN(4), VCAM1(28), VCAN(104)	115140551	1425	388	1411	439	177	629	281	114	218	6	0.0486	1.000	1.000
114	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	160	ADORA1(9), ADORA2A(3), ADORA2B(1), ADORA3(4), ADRA1A(7), ADRA1B(8), ADRA1D(8), ADRA2A(3), ADRA2C(3), ADRB1(1), ADRB2(4), ADRB3(6), AGTR1(9), AGTR2(6), AVPR1A(14), AVPR1B(7), AVPR2(7), BDKRB1(1), BDKRB2(3), BRS3(8), C3AR1(11), CCKAR(14), CCKBR(24), CCR1(3), CCR10(1), CCR2(6), CCR3(4), CCR4(3), CCR5(4), CCR6(9), CCR8(6), CCRL2(2), CHML(12), CHRM1(5), CHRM2(39), CHRM3(27), CHRM4(8), CHRM5(6), CNR1(15), CNR2(3), CX3CR1(11), CXCR3(3), CXCR4(6), DRD1(13), DRD3(19), DRD4(2), DRD5(26), EDNRA(3), EDNRB(16), F2R(10), F2RL1(2), F2RL2(12), F2RL3(2), FPR1(10), FSHR(37), GALR1(8), GALR2(3), GALR3(1), GALT(5), GHSR(5), GNB2L1(3), GPR17(8), GPR173(4), GPR174(18), GPR27(5), GPR35(8), GPR37(17), GPR4(7), GPR50(21), GPR6(8), GPR63(10), GPR83(12), GPR85(16), GPR87(4), GRPR(7), HCRTR1(4), HCRTR2(24), HRH1(5), HRH2(17), HRH3(7), HTR1A(24), HTR1B(7), HTR1D(5), HTR1E(23), HTR1F(10), HTR2A(6), HTR2B(5), HTR2C(8), HTR4(6), HTR5A(21), HTR6(10), HTR7(11), LHCGR(14), LTB4R(5), MAS1(5), MC1R(2), MC3R(16), MC4R(3), MC5R(22), MLNR(2), MTNR1A(15), MTNR1B(13), NMBR(8), NMUR1(9), NMUR2(23), NPY1R(17), NPY2R(20), NPY5R(22), NTSR1(10), NTSR2(6), OPN1SW(8), OPN3(3), OPRD1(2), OPRK1(12), OPRL1(14), OPRM1(12), OR10A5(14), OR11A1(8), OR12D3(4), OR1C1(29), OR1F1(3), OR1Q1(11), OR2H1(16), OR5V1(6), OR7A5(6), OR7C1(5), OR8B8(12), OXTR(4), P2RY1(4), P2RY10(23), P2RY11(2), P2RY12(2), P2RY13(1), P2RY14(2), P2RY2(3), P2RY6(2), PTAFR(5), PTGDR(8), PTGER2(4), PTGER4(7), PTGFR(12), PTGIR(6), RGR(4), RHO(7), RRH(2), SSTR1(9), SSTR2(4), SSTR3(8), SSTR4(15), SUCNR1(1), TBXA2R(1), TRHR(14)	96041042	1376	384	1356	497	214	580	302	131	146	3	0.0443	1.000	1.000
115	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	141	APC(33), APC2(8), AXIN1(7), AXIN2(5), BTRC(12), CACYBP(1), CAMK2A(3), CAMK2B(16), CAMK2D(7), CCND1(3), CCND2(4), CCND3(1), CER1(7), CHD8(29), CREBBP(30), CSNK1A1(2), CSNK1A1L(14), CSNK1E(6), CSNK2A1(5), CSNK2A2(2), CTBP1(2), CUL1(14), CXXC4(2), DAAM1(8), DAAM2(4), DKK1(3), DKK2(14), DKK4(2), DVL1(5), DVL2(7), DVL3(13), EP300(11), FBXW11(2), FOSL1(4), FZD1(6), FZD10(26), FZD2(8), FZD3(2), FZD4(5), FZD5(5), FZD6(3), FZD7(7), FZD8(6), FZD9(4), GSK3B(4), JUN(3), LEF1(12), LRP5(17), LRP6(16), MAP3K7(10), MAPK10(6), MAPK8(2), MAPK9(8), MMP7(7), MYC(4), NFAT5(13), NFATC1(9), NFATC2(15), NFATC3(15), NFATC4(11), NKD1(6), NKD2(8), NLK(3), PLCB1(52), PLCB2(12), PLCB3(9), PLCB4(35), PORCN(7), PPARD(6), PPP2CA(1), PPP2CB(3), PPP2R1A(10), PPP2R1B(5), PPP2R2A(8), PPP2R2B(12), PPP2R2C(5), PPP3CB(3), PPP3CC(3), PPP3R1(5), PRICKLE1(11), PRICKLE2(9), PRKACA(3), PRKACB(9), PRKACG(4), PRKCA(10), PRKCG(20), PRKX(3), PSEN1(6), RAC2(2), RHOA(4), ROCK1(19), ROCK2(9), RUVBL1(4), SENP2(6), SFRP1(2), SFRP2(6), SFRP4(7), SFRP5(1), SIAH1(1), SKP1(4), SMAD2(7), SMAD3(6), SMAD4(21), SOX17(1), TBL1X(5), TBL1XR1(6), TBL1Y(1), TCF7(3), TCF7L1(6), TCF7L2(7), VANGL1(9), VANGL2(15), WIF1(3), WNT1(6), WNT10A(10), WNT10B(10), WNT11(6), WNT16(9), WNT2(7), WNT2B(4), WNT3A(10), WNT4(1), WNT5A(2), WNT5B(6), WNT7A(14), WNT7B(4), WNT8A(9), WNT8B(8), WNT9A(6), WNT9B(6)	126116160	1051	375	1041	313	178	387	203	97	184	2	0.0864	1.000	1.000
116	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	141	ADA(3), ADCY1(26), ADCY2(51), ADCY3(7), ADCY4(12), ADCY5(27), ADCY6(10), ADCY7(13), ADCY8(48), ADCY9(12), ADK(2), ADSL(2), ADSS(6), ADSSL1(4), AK2(4), AK5(14), AK7(13), ALLC(7), AMPD1(20), AMPD2(7), AMPD3(3), APRT(1), ATIC(7), CANT1(3), DCK(2), DGUOK(4), ENPP1(14), ENPP3(19), ENTPD1(7), ENTPD2(2), ENTPD4(4), ENTPD5(1), ENTPD6(6), ENTPD8(1), FHIT(2), GART(9), GDA(11), GMPR(5), GMPR2(1), GMPS(9), GUCY1A2(28), GUCY1A3(16), GUCY1B3(10), GUCY2C(11), GUCY2D(5), GUCY2F(28), GUK1(2), HPRT1(1), IMPDH1(7), ITPA(1), NME6(3), NME7(4), NPR1(16), NPR2(6), NT5C1A(12), NT5C1B(11), NT5C2(3), NT5E(5), NT5M(3), NUDT2(3), NUDT5(2), NUDT9(2), PAICS(1), PAPSS1(5), PAPSS2(10), PDE10A(31), PDE11A(24), PDE1A(17), PDE1C(28), PDE2A(11), PDE3B(16), PDE4A(7), PDE4B(14), PDE4C(4), PDE4D(5), PDE5A(8), PDE6G(3), PDE7A(3), PDE7B(6), PDE8A(3), PDE8B(10), PDE9A(7), PFAS(9), PKLR(16), PNPT1(12), POLA1(19), POLA2(7), POLD1(7), POLD2(3), POLD3(2), POLD4(2), POLE(31), POLE2(1), POLE4(1), POLR1A(13), POLR1B(11), POLR1D(2), POLR2A(11), POLR2B(10), POLR2C(4), POLR2D(3), POLR2E(2), POLR2F(1), POLR2G(1), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(2), POLR3A(17), POLR3B(20), POLR3G(2), POLR3H(1), POLR3K(2), PPAT(1), PRIM1(3), PRPS1(3), PRPS1L1(3), PRPS2(4), PRUNE(5), RFC5(3), RRM1(6), RRM2(6), RRM2B(3), XDH(18), ZNRD1(1)	130309123	1063	370	1057	346	121	398	248	112	182	2	0.617	1.000	1.000
117	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	89	ADCY1(26), ADCY2(51), ADCY3(7), ADCY4(12), ADCY5(27), ADCY6(10), ADCY7(13), ADCY8(48), ADCY9(12), ADRB1(1), CSNK1D(7), DRD1(13), EGF(13), GJA1(11), GJD2(6), GNA11(4), GNAI1(10), GNAI3(2), GNAQ(5), GNAS(29), GRB2(6), GRM1(48), GRM5(40), GUCY1A2(28), GUCY1A3(16), GUCY1B3(10), GUCY2C(11), GUCY2D(5), GUCY2F(28), HRAS(2), HTR2A(6), HTR2B(5), HTR2C(8), ITPR1(20), ITPR2(40), ITPR3(21), MAP2K1(10), MAP2K2(1), MAP2K5(4), MAP3K2(6), MAPK1(2), MAPK3(3), MAPK7(7), NPR1(16), NPR2(6), NRAS(4), PDGFA(5), PDGFB(2), PDGFC(3), PDGFD(9), PDGFRA(41), PDGFRB(18), PLCB1(52), PLCB2(12), PLCB3(9), PLCB4(35), PRKACA(3), PRKACB(9), PRKACG(4), PRKCA(10), PRKCG(20), PRKG1(20), PRKG2(15), PRKX(3), RAF1(6), SOS1(17), SOS2(13), SRC(2), TJP1(15), TUBA1A(4), TUBA1B(3), TUBA1C(4), TUBA3C(28), TUBA3D(13), TUBA3E(9), TUBA4A(3), TUBA8(1), TUBAL3(3), TUBB(2), TUBB1(6), TUBB2A(3), TUBB2B(4), TUBB3(3), TUBB6(3), TUBB8(17)	102719217	1089	369	1074	353	149	424	234	105	174	3	0.292	1.000	1.000
118	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(9), ACTA2(1), ACTN2(43), ACTN4(6), DES(4), DMD(108), MYBPC1(21), MYBPC2(8), MYBPC3(15), MYH3(37), MYH6(42), MYH7(59), MYH8(73), MYL1(4), MYL2(8), MYL3(4), MYL4(2), MYL9(3), MYOM1(16), NEB(91), TCAP(1), TMOD1(5), TNNC2(2), TNNI1(3), TNNI2(4), TNNI3(6), TNNT1(3), TNNT2(6), TNNT3(5), TPM1(1), TPM2(3), TPM3(2), TPM4(2), TTN(654), VIM(5)	110040676	1256	368	1243	364	127	537	301	128	150	13	0.571	1.000	1.000
119	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	147	AKT1(3), AKT2(7), AKT3(7), BCL2L1(3), CBL(10), CBLB(10), CBLC(1), CCND1(3), CCND2(4), CCND3(1), CISH(1), CNTF(6), CNTFR(5), CREBBP(30), CRLF2(9), CSF2RA(8), CSF2RB(14), CSF3R(6), EP300(11), EPO(6), EPOR(2), GH1(7), GH2(7), GHR(19), GRB2(6), IFNA1(2), IFNA10(7), IFNA14(4), IFNA16(8), IFNA17(5), IFNA2(5), IFNA21(3), IFNA4(4), IFNA5(5), IFNA7(6), IFNA8(7), IFNAR1(4), IFNAR2(7), IFNB1(7), IFNG(7), IFNGR1(7), IFNGR2(4), IFNK(1), IFNW1(2), IL10(2), IL10RA(6), IL10RB(6), IL11RA(1), IL12A(2), IL12B(3), IL12RB1(5), IL12RB2(15), IL13(2), IL13RA1(3), IL13RA2(13), IL15(6), IL15RA(2), IL19(2), IL2(7), IL20(2), IL20RA(5), IL21(2), IL21R(14), IL22(4), IL22RA1(7), IL22RA2(6), IL23R(6), IL24(3), IL26(3), IL2RA(6), IL2RB(7), IL2RG(5), IL3(4), IL3RA(8), IL4(1), IL4R(10), IL5(2), IL5RA(9), IL6(2), IL6R(8), IL6ST(3), IL7(2), IL7R(21), IL9(1), IL9R(16), IRF9(3), JAK1(11), JAK2(16), JAK3(10), LEP(4), LEPR(26), LIF(3), LIFR(14), MPL(5), MYC(4), OSM(5), OSMR(7), PIAS1(2), PIAS2(6), PIAS3(7), PIAS4(2), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PIM1(1), PRL(3), PRLR(18), PTPN11(9), PTPN6(6), SOCS2(3), SOCS4(1), SOCS5(8), SOCS7(2), SOS1(17), SOS2(13), SPRED1(5), SPRED2(4), SPRY1(3), SPRY2(5), SPRY3(9), SPRY4(4), STAM(11), STAM2(5), STAT1(7), STAT2(6), STAT3(11), STAT4(11), STAT5A(3), STAT5B(8), STAT6(2), TPO(33), TYK2(5)	114260646	929	360	923	297	91	368	202	100	167	1	0.814	1.000	1.000
120	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	64	ADCY1(26), ADCY8(48), ARAF(5), ATF4(2), CACNA1C(61), CALM1(3), CALM2(1), CALML3(3), CALML6(1), CAMK2A(3), CAMK2B(16), CAMK2D(7), CAMK4(16), CREBBP(30), EP300(11), GNAQ(5), GRIA1(18), GRIA2(28), GRIN1(9), GRIN2A(61), GRIN2B(53), GRIN2C(8), GRIN2D(9), GRM1(48), GRM5(40), HRAS(2), ITPR1(20), ITPR2(40), ITPR3(21), MAP2K1(10), MAP2K2(1), MAPK1(2), MAPK3(3), NRAS(4), PLCB1(52), PLCB2(12), PLCB3(9), PLCB4(35), PPP1CA(2), PPP1CB(4), PPP1CC(1), PPP1R12A(8), PPP1R1A(2), PPP3CB(3), PPP3CC(3), PPP3R1(5), PRKACA(3), PRKACB(9), PRKACG(4), PRKCA(10), PRKCG(20), PRKX(3), RAF1(6), RAP1A(1), RAP1B(2), RAPGEF3(7), RPS6KA1(6), RPS6KA2(8), RPS6KA3(6), RPS6KA6(18)	77212596	854	355	843	257	124	356	178	67	126	3	0.0577	1.000	1.000
121	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	93	ADCY1(26), ADCY2(51), ADCY3(7), ADCY4(12), ADCY5(27), ADCY6(10), ADCY7(13), ADCY8(48), ADCY9(12), ATF4(2), CACNA1C(61), CACNA1D(21), CACNA1F(30), CACNA1S(23), CALM1(3), CALM2(1), CALML3(3), CALML6(1), CAMK2A(3), CAMK2B(16), CAMK2D(7), CDC42(1), CGA(2), ELK1(3), FSHB(4), GNA11(4), GNAQ(5), GNAS(29), GNRH1(1), GNRHR(5), GRB2(6), HRAS(2), ITPR1(20), ITPR2(40), ITPR3(21), JUN(3), LHB(3), MAP2K1(10), MAP2K2(1), MAP2K3(13), MAP2K4(8), MAP2K6(5), MAP2K7(7), MAP3K1(7), MAP3K2(6), MAP3K3(10), MAP3K4(21), MAPK1(2), MAPK10(6), MAPK12(2), MAPK13(1), MAPK14(4), MAPK3(3), MAPK7(7), MAPK8(2), MAPK9(8), MMP14(4), MMP2(24), NRAS(4), PLA2G12A(4), PLA2G12B(3), PLA2G1B(2), PLA2G2A(5), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(6), PLA2G4A(21), PLA2G6(3), PLCB1(52), PLCB2(12), PLCB3(9), PLCB4(35), PLD1(19), PLD2(7), PRKACA(3), PRKACB(9), PRKACG(4), PRKCA(10), PRKCD(7), PRKX(3), PTK2B(14), RAF1(6), SOS1(17), SOS2(13), SRC(2)	99192449	953	355	938	318	153	362	195	81	161	1	0.450	1.000	1.000
122	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	72	ARAF(5), CACNA1A(32), CRH(3), CRHR1(7), GNA11(4), GNA12(1), GNA13(6), GNAI1(10), GNAI3(2), GNAO1(7), GNAQ(5), GNAS(29), GNAZ(5), GRIA1(18), GRIA2(28), GRIA3(24), GRID2(54), GRM1(48), GRM5(40), GUCY1A2(28), GUCY1A3(16), GUCY1B3(10), GUCY2C(11), GUCY2D(5), GUCY2F(28), HRAS(2), IGF1(4), IGF1R(8), ITPR1(20), ITPR2(40), ITPR3(21), LYN(6), MAP2K1(10), MAP2K2(1), MAPK1(2), MAPK3(3), NOS1(29), NOS3(12), NPR1(16), NPR2(6), NRAS(4), PLA2G12A(4), PLA2G12B(3), PLA2G1B(2), PLA2G2A(5), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(6), PLA2G4A(21), PLA2G6(3), PLCB1(52), PLCB2(12), PLCB3(9), PLCB4(35), PPP2CA(1), PPP2CB(3), PPP2R1A(10), PPP2R1B(5), PPP2R2A(8), PPP2R2B(12), PPP2R2C(5), PRKCA(10), PRKCG(20), PRKG1(20), PRKG2(15), RAF1(6), RYR1(111)	86640418	994	349	984	288	151	385	202	88	164	4	0.0126	1.000	1.000
123	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	127	ACACA(20), ACACB(28), AKT1(3), AKT2(7), AKT3(7), ARAF(5), CALM1(3), CALM2(1), CALML3(3), CALML6(1), CBL(10), CBLB(10), CBLC(1), CRK(1), CRKL(4), ELK1(3), EXOC7(4), FASN(18), FBP1(2), FBP2(2), FLOT1(1), FLOT2(4), FOXO1(5), G6PC(7), G6PC2(8), GCK(6), GRB2(6), GSK3B(4), GYS1(4), GYS2(8), HRAS(2), IKBKB(9), INPP5D(11), INSR(10), IRS1(20), IRS4(34), LIPE(5), MAP2K1(10), MAP2K2(1), MAPK1(2), MAPK10(6), MAPK3(3), MAPK8(2), MAPK9(8), MKNK1(4), MKNK2(2), NRAS(4), PCK1(21), PCK2(4), PDE3A(30), PDE3B(16), PDPK1(3), PFKL(9), PFKM(7), PFKP(5), PHKA1(16), PHKA2(14), PHKB(10), PHKG1(5), PHKG2(4), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PKLR(16), PPARGC1A(23), PPP1CA(2), PPP1CB(4), PPP1CC(1), PPP1R3A(48), PPP1R3B(1), PPP1R3C(3), PPP1R3D(5), PRKAA1(6), PRKAA2(8), PRKAB1(3), PRKACA(3), PRKACB(9), PRKACG(4), PRKAG1(1), PRKAG2(5), PRKAG3(8), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PRKCI(11), PRKCZ(4), PRKX(3), PTPN1(3), PTPRF(15), PYGB(5), PYGL(6), PYGM(9), RAF1(6), RAPGEF1(7), RHEB(4), RHOQ(1), RPS6(3), RPS6KB1(3), RPS6KB2(3), SH2B2(6), SHC1(6), SHC2(5), SHC3(8), SHC4(7), SLC2A4(4), SOCS2(3), SOCS4(1), SORBS1(12), SOS1(17), SOS2(13), SREBF1(3), TRIP10(2), TSC1(10), TSC2(13)	123443898	895	345	883	316	138	333	192	89	140	3	0.900	1.000	1.000
124	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	79	AGL(21), AMY2A(6), AMY2B(11), ASCC3(23), ATP13A2(11), DDX18(9), DDX23(5), DDX4(10), DDX41(3), DDX47(1), DDX50(12), DDX52(4), DDX54(7), DDX55(3), DDX56(3), DHX58(4), ENPP1(14), ENPP3(19), ENTPD7(6), EP400(32), ERCC2(5), ERCC3(5), G6PC(7), G6PC2(8), GAA(12), GANC(3), GBA(7), GBE1(8), GCK(6), GPI(8), GUSB(5), GYS1(4), GYS2(8), HK1(12), HK2(11), HK3(22), IFIH1(10), LYZL1(5), MGAM(51), MOV10L1(11), NUDT5(2), NUDT8(2), PGM1(3), PGM3(3), PYGB(5), PYGL(6), PYGM(9), RAD54B(8), RAD54L(7), RUVBL2(4), SETX(27), SI(117), SKIV2L2(15), SMARCA2(22), SMARCA5(5), TREH(1), UGDH(6), UGP2(4), UGT1A1(12), UGT1A10(9), UGT1A3(6), UGT1A4(4), UGT1A5(8), UGT1A6(9), UGT1A7(7), UGT1A9(7), UGT2A1(16), UGT2A3(11), UGT2B10(9), UGT2B11(23), UGT2B15(14), UGT2B17(12), UGT2B4(28), UGT2B7(14), UXS1(6)	98662401	853	341	846	234	93	358	186	81	135	0	0.0748	1.000	1.000
125	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	108	A4GNT(6), ALG1(2), ALG10(15), ALG10B(8), ALG11(7), ALG12(3), ALG13(15), ALG14(1), ALG2(3), ALG3(4), ALG6(1), ALG8(3), ALG9(5), B3GNT1(3), B3GNT2(4), B3GNT6(5), B3GNT7(5), B4GALT1(1), B4GALT2(4), B4GALT3(2), B4GALT4(2), B4GALT5(6), C1GALT1(5), C1GALT1C1(4), CHPF(10), CHST1(17), CHST11(2), CHST12(6), CHST13(3), CHST14(2), CHST2(14), CHST3(1), CHST4(3), CHST6(7), CHST7(2), CHSY1(5), DAD1(2), DDOST(1), DPAGT1(5), EXT1(8), EXT2(11), EXTL1(8), EXTL2(3), EXTL3(13), FUT11(5), FUT8(7), GALNT1(6), GALNT10(6), GALNT11(3), GALNT12(3), GALNT13(35), GALNT14(24), GALNT2(11), GALNT3(12), GALNT4(4), GALNT5(10), GALNT6(5), GALNT7(9), GALNT8(19), GALNTL5(5), GANAB(9), GCNT1(8), GCNT3(2), GCNT4(9), HS2ST1(1), HS3ST1(8), HS3ST2(7), HS3ST3A1(7), HS3ST5(18), HS6ST1(5), HS6ST2(3), HS6ST3(12), MAN1A1(3), MAN1A2(7), MAN1B1(4), MAN1C1(3), MAN2A1(20), MGAT1(7), MGAT2(5), MGAT3(15), MGAT4A(3), MGAT4B(7), MGAT5(13), MGAT5B(22), NDST1(6), NDST2(6), NDST3(16), NDST4(36), OGT(19), RPN1(3), RPN2(4), ST3GAL1(4), ST3GAL2(4), ST3GAL3(4), ST3GAL4(4), ST6GAL1(4), ST6GALNAC1(8), STT3B(4), UST(5), WBSCR17(33), XYLT1(44), XYLT2(3)	88486212	806	341	797	271	127	297	187	85	108	2	0.672	1.000	1.000
126	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(17), ABCA10(34), ABCA12(39), ABCA13(86), ABCA2(21), ABCA3(11), ABCA4(19), ABCA5(23), ABCA6(26), ABCA7(18), ABCA8(25), ABCA9(26), ABCB1(45), ABCB10(11), ABCB11(28), ABCB4(19), ABCB5(60), ABCB6(4), ABCB7(12), ABCB8(11), ABCB9(7), ABCC1(14), ABCC10(11), ABCC11(38), ABCC12(22), ABCC2(11), ABCC3(13), ABCC4(21), ABCC5(14), ABCC6(9), ABCC8(25), ABCC9(30), ABCD1(2), ABCD2(14), ABCD3(2), ABCD4(5), ABCG1(8), ABCG2(14), ABCG4(16), ABCG5(19), ABCG8(19), CFTR(11), TAP1(1), TAP2(8)	94274026	869	341	863	263	85	335	202	88	155	4	0.109	1.000	1.000
127	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	108	ACTN1(7), ACTN2(43), ACTN4(6), ARHGAP5(17), BCAR1(3), CD99(3), CDC42(1), CDH5(13), CLDN1(1), CLDN10(7), CLDN11(4), CLDN14(6), CLDN15(1), CLDN16(8), CLDN17(10), CLDN18(5), CLDN2(5), CLDN20(2), CLDN22(1), CLDN4(3), CLDN6(2), CLDN8(6), CLDN9(2), CTNNA1(9), CTNNA2(65), CTNNA3(22), CTNND1(10), CXCL12(3), CXCR4(6), CYBA(1), CYBB(11), ESAM(2), EZR(3), F11R(3), GNAI1(10), GNAI3(2), ICAM1(2), ITGA4(38), ITGAL(26), ITGAM(24), ITGB1(6), ITGB2(8), ITK(16), JAM2(9), JAM3(4), MAPK12(2), MAPK13(1), MAPK14(4), MLLT4(12), MMP2(24), MMP9(10), MSN(8), MYL2(8), MYL5(2), MYL7(4), MYL9(3), NCF1(3), NCF2(8), NCF4(3), NOX1(8), NOX3(21), OCLN(1), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PLCG1(7), PLCG2(18), PRKCA(10), PRKCG(20), PTK2(6), PTK2B(14), PTPN11(9), PXN(1), RAC2(2), RAP1A(1), RAP1B(2), RAPGEF3(7), RAPGEF4(13), RHOA(4), RHOH(6), ROCK1(19), ROCK2(9), SIPA1(2), THY1(6), TXK(7), VASP(2), VAV1(8), VAV2(8), VAV3(32), VCAM1(28), VCL(8)	96343127	885	337	879	275	113	375	185	73	137	2	0.200	1.000	1.000
128	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	97	ADCY1(26), ADCY2(51), ADCY3(7), ADCY4(12), ADCY5(27), ADCY6(10), ADCY7(13), ADCY8(48), ADCY9(12), ASIP(1), CALM1(3), CALM2(1), CALML3(3), CALML6(1), CAMK2A(3), CAMK2B(16), CAMK2D(7), CREB1(2), CREB3L1(4), CREB3L2(8), CREB3L3(3), CREB3L4(2), CREBBP(30), DCT(16), DVL1(5), DVL2(7), DVL3(13), EDN1(1), EDNRB(16), EP300(11), FZD1(6), FZD10(26), FZD2(8), FZD3(2), FZD4(5), FZD5(5), FZD6(3), FZD7(7), FZD8(6), FZD9(4), GNAI1(10), GNAI3(2), GNAO1(7), GNAQ(5), GNAS(29), GSK3B(4), HRAS(2), KIT(12), KITLG(6), LEF1(12), MAP2K1(10), MAP2K2(1), MAPK1(2), MAPK3(3), MC1R(2), MITF(3), NRAS(4), PLCB1(52), PLCB2(12), PLCB3(9), PLCB4(35), POMC(4), PRKACA(3), PRKACB(9), PRKACG(4), PRKCA(10), PRKCG(20), PRKX(3), RAF1(6), TCF7(3), TCF7L1(6), TCF7L2(7), TYR(29), TYRP1(5), WNT1(6), WNT10A(10), WNT10B(10), WNT11(6), WNT16(9), WNT2(7), WNT2B(4), WNT3A(10), WNT4(1), WNT5A(2), WNT5B(6), WNT7A(14), WNT7B(4), WNT8A(9), WNT8B(8), WNT9A(6), WNT9B(6)	85137721	880	333	866	295	165	324	188	70	131	2	0.249	1.000	1.000
129	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	109	ADA(3), ADCY1(26), ADCY2(51), ADCY3(7), ADCY4(12), ADCY5(27), ADCY6(10), ADCY7(13), ADCY8(48), ADK(2), ADSL(2), ADSS(6), AK2(4), AK5(14), ALLC(7), AMPD1(20), AMPD2(7), AMPD3(3), APRT(1), ATIC(7), ATP1B1(6), ATP5A1(4), ATP5B(3), ATP5C1(4), ATP5F1(3), ATP5G3(2), ATP5J2(3), CANT1(3), DCK(2), DGUOK(4), ENPP1(14), ENPP3(19), ENTPD1(7), ENTPD2(2), FHIT(2), GART(9), GDA(11), GMPS(9), GUCY1A2(28), GUCY1A3(16), GUCY1B3(10), GUCY2C(11), GUCY2D(5), GUCY2F(28), GUK1(2), HPRT1(1), IMPDH1(7), ITPA(1), NPR1(16), NPR2(6), NT5E(5), NT5M(3), NUDT2(3), PAICS(1), PAPSS1(5), PAPSS2(10), PDE1A(17), PDE4A(7), PDE4B(14), PDE4C(4), PDE4D(5), PDE5A(8), PDE6B(15), PDE6C(12), PDE6G(3), PDE7B(6), PDE8A(3), PDE9A(7), PFAS(9), PKLR(16), POLB(4), POLD1(7), POLD2(3), POLE(31), POLG(12), POLL(7), POLQ(36), POLR1B(11), POLR2A(11), POLR2B(10), POLR2C(4), POLR2D(3), POLR2E(2), POLR2F(1), POLR2G(1), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(2), POLRMT(8), PPAT(1), PRPS1(3), PRPS1L1(3), PRPS2(4), PRUNE(5), RRM1(6), RRM2(6)	102556225	846	333	841	281	101	313	191	90	149	2	0.678	1.000	1.000
130	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(3), AKT3(7), BCAR1(3), CAPN1(2), CAPN10(8), CAPN11(13), CAPN2(5), CAPN3(8), CAPN5(12), CAPN6(25), CAPN7(7), CAPN9(5), CAPNS1(1), CAV1(1), CAV2(1), CAV3(3), CDC42(1), CRK(1), CSK(2), DOCK1(15), FYN(8), GIT2(5), GRB2(6), ILK(1), ITGA10(16), ITGA11(12), ITGA2(25), ITGA2B(12), ITGA3(8), ITGA4(38), ITGA5(11), ITGA6(12), ITGA7(13), ITGA8(59), ITGA9(6), ITGAD(38), ITGAE(20), ITGAL(26), ITGAM(24), ITGAV(14), ITGAX(52), ITGB1(6), ITGB2(8), ITGB3(13), ITGB4(10), ITGB5(4), ITGB6(11), ITGB7(2), ITGB8(15), MAP2K1(10), MAP2K2(1), MAP2K3(13), MAP2K6(5), MAPK10(6), MAPK12(2), MAPK4(9), MAPK6(4), MAPK7(7), MYLK2(9), PAK1(9), PAK2(3), PAK3(16), PAK4(6), PAK6(2), PDPK1(3), PIK3R2(7), PTK2(6), PXN(1), RAC2(2), RAP1B(2), RAPGEF1(7), RHO(7), ROCK1(19), ROCK2(9), SDCCAG8(12), SEPP1(1), SHC1(6), SHC3(8), SORBS1(12), SOS1(17), SRC(2), TLN1(15), TNS1(23), VASP(2), VAV2(8), VAV3(32), VCL(8), ZYX(6)	107108167	915	332	904	268	88	386	192	75	170	4	0.108	1.000	1.000
131	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	73	ACP1(4), ACTB(10), ACTG1(6), ACTN1(7), ACTN2(43), ACTN4(6), ACVR1B(11), ACVR1C(11), BAIAP2(3), CDC42(1), CDH1(6), CREBBP(30), CSNK2A1(5), CSNK2A2(2), CTNNA1(9), CTNNA2(65), CTNNA3(22), CTNND1(10), EP300(11), ERBB2(12), FARP2(7), FER(16), FGFR1(4), FYN(8), IGF1R(8), INSR(10), IQGAP1(8), LEF1(12), LMO7(22), MAP3K7(10), MAPK1(2), MAPK3(3), MET(22), MLLT4(12), NLK(3), PARD3(15), PTPN1(3), PTPN6(6), PTPRB(50), PTPRF(15), PTPRJ(12), PTPRM(14), PVRL1(16), PVRL3(7), PVRL4(9), RAC2(2), RHOA(4), SMAD2(7), SMAD3(6), SMAD4(21), SNAI1(3), SNAI2(14), SORBS1(12), SRC(2), SSX2IP(3), TCF7(3), TCF7L1(6), TCF7L2(7), TGFBR1(7), TGFBR2(7), TJP1(15), VCL(8), WAS(8), WASF1(10), WASF2(3), WASF3(13), WASL(7), YES1(3)	93102896	739	329	725	204	107	256	150	73	153	0	0.0503	1.000	1.000
132	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	65	A2M(24), BDKRB1(1), BDKRB2(3), C1QA(7), C1QB(11), C1QC(5), C1R(4), C1S(4), C2(10), C3(13), C3AR1(11), C4BPA(6), C4BPB(1), C5(6), C5AR1(7), C6(29), C8A(18), C8B(20), C9(20), CD46(3), CD55(3), CFB(4), CFH(46), CFI(6), CPB2(6), CR1(34), CR2(20), F10(5), F11(13), F12(4), F13A1(29), F13B(28), F2(9), F2R(10), F3(3), F5(40), F7(10), F8(56), F9(20), FGA(20), FGB(18), FGG(4), KLKB1(6), KNG1(9), MASP1(13), MASP2(8), MBL2(13), PLAT(12), PLAUR(4), PLG(32), PROC(4), PROS1(30), SERPINA1(4), SERPINA5(18), SERPINC1(5), SERPIND1(3), SERPINE1(14), SERPINF2(2), SERPING1(7), TFPI(4), THBD(4), VWF(32)	71504592	815	328	805	239	72	379	146	71	145	2	0.260	1.000	1.000
133	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	80	ACVR1(7), ACVR1B(11), ACVRL1(11), AKT1(3), AURKB(2), BMPR1A(4), BMPR2(10), BUB1(10), CDIPT(1), CDKL1(1), CDKL2(2), CDS1(3), CDS2(4), CLK1(3), CLK2(10), CLK4(4), COL4A3BP(2), CSNK2A1(5), CSNK2A2(2), DGKA(7), DGKB(40), DGKD(10), DGKE(5), DGKG(15), DGKH(14), DGKQ(1), DGKZ(5), IMPA1(1), INPP1(8), INPP4A(7), INPP4B(27), INPP5A(3), INPPL1(11), ITPKA(2), ITPKB(7), MAP3K10(4), MOS(9), NEK1(11), NEK3(4), OCRL(13), PAK4(6), PIK3C2A(12), PIK3C2B(22), PIK3C2G(19), PIK3CB(8), PIK3CG(33), PIM2(7), PLCB1(52), PLCB2(12), PLCB3(9), PLCB4(35), PLCD1(4), PLCG1(7), PLCG2(18), PLK3(4), PRKACA(3), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PRKCA(10), PRKCD(7), PRKCE(5), PRKCG(20), PRKCH(6), PRKCQ(12), PRKCZ(4), PRKD1(31), PRKG1(20), RAF1(6), RPS6KA1(6), RPS6KA2(8), RPS6KA3(6), RPS6KA4(4), RPS6KB1(3), TGFBR1(7), VRK1(6)	88089357	735	328	728	204	107	279	152	73	120	4	0.0797	1.000	1.000
134	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	75	ABL1(9), ACTN1(7), ACTR2(4), ACTR3(2), AKT1(3), AKT2(7), AKT3(7), ANGPTL2(5), ARHGEF6(21), ARHGEF7(6), BCAR1(3), CAV1(1), CDC42(1), CRK(1), CSE1L(7), DOCK1(15), EPHB2(10), FYN(8), GRB2(6), GRB7(8), ILK(1), ITGA1(14), ITGA10(16), ITGA11(12), ITGA2(25), ITGA3(8), ITGA4(38), ITGA5(11), ITGA6(12), ITGA7(13), ITGA8(59), ITGA9(6), MAP2K4(8), MAP2K7(7), MAP3K11(5), MAPK1(2), MAPK10(6), MAPK8(2), MAPK8IP1(4), MAPK8IP2(2), MAPK8IP3(7), MAPK9(8), MRAS(1), MYLK(26), MYLK2(9), P4HB(5), PAK1(9), PAK2(3), PAK3(16), PAK4(6), PAK6(2), PAK7(37), PIK3CB(8), PKLR(16), PLCG1(7), PLCG2(18), PTEN(11), PTK2(6), RAF1(6), RALA(5), RHO(7), ROCK1(19), ROCK2(9), SHC1(6), SOS1(17), SOS2(13), SRC(2), TLN1(15), TLN2(30), VASP(2), WAS(8), ZYX(6)	94485927	722	327	708	224	94	275	145	60	147	1	0.401	1.000	1.000
135	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	106	ABL1(9), ANAPC1(12), ANAPC10(1), ANAPC11(1), ANAPC2(5), ANAPC4(6), ANAPC5(8), ANAPC7(5), ATM(53), ATR(26), BUB1(10), BUB1B(10), BUB3(4), CCNA1(7), CCNA2(6), CCNB1(2), CCNB3(35), CCND1(3), CCND2(4), CCND3(1), CCNE1(7), CCNE2(3), CCNH(3), CDC14A(10), CDC14B(3), CDC16(2), CDC20(8), CDC23(3), CDC25A(4), CDC25B(1), CDC25C(8), CDC27(7), CDC6(4), CDC7(6), CDK2(1), CDK4(3), CDK6(5), CDK7(3), CDKN1A(2), CDKN1B(5), CDKN2D(2), CHEK1(7), CHEK2(10), CREBBP(30), CUL1(14), DBF4(6), E2F1(3), E2F2(5), E2F3(2), EP300(11), ESPL1(6), FZR1(3), GADD45A(2), GADD45B(1), GADD45G(1), GSK3B(4), HDAC1(4), HDAC2(8), MAD1L1(6), MAD2L1(5), MAD2L2(2), MCM2(5), MCM3(12), MCM4(11), MCM5(10), MCM6(16), MCM7(5), MDM2(5), PCNA(1), PKMYT1(3), PLK1(9), PRKDC(50), PTTG1(2), RBL1(7), RBL2(5), SFN(1), SKP1(4), SKP2(3), SMAD2(7), SMAD3(6), SMAD4(21), SMC1A(9), SMC1B(8), TFDP1(10), TGFB1(3), TGFB2(10), WEE1(4), YWHAB(1), YWHAE(1), YWHAG(3), YWHAH(1), YWHAQ(4), YWHAZ(2)	106514915	667	325	663	147	91	208	140	83	142	3	0.000425	1.000	1.000
136	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	72	CALM1(3), CALM2(1), CALML3(3), CALML6(1), CDIPT(1), CDS1(3), CDS2(4), DGKA(7), DGKB(40), DGKD(10), DGKE(5), DGKG(15), DGKH(14), DGKI(35), DGKQ(1), DGKZ(5), FN3K(1), IMPA1(1), IMPA2(1), INPP1(8), INPP4A(7), INPP4B(27), INPP5A(3), INPP5B(10), INPP5D(11), INPP5E(2), INPPL1(11), ITPK1(1), ITPKA(2), ITPKB(7), ITPR1(20), ITPR2(40), ITPR3(21), OCRL(13), PI4KA(17), PI4KB(10), PIK3C2A(12), PIK3C2B(22), PIK3C2G(19), PIK3C3(14), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PIP4K2A(7), PIP4K2B(3), PIP4K2C(7), PIP5K1A(6), PIP5K1B(6), PIP5K1C(4), PLCB1(52), PLCB2(12), PLCB3(9), PLCB4(35), PLCD1(4), PLCD3(2), PLCD4(7), PLCE1(28), PLCG1(7), PLCG2(18), PLCZ1(8), PRKCA(10), PRKCG(20), PTEN(11), PTPMT1(1), SYNJ1(14), SYNJ2(9)	97716098	786	323	780	228	102	291	176	69	144	4	0.117	1.000	1.000
137	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	121	ARAF(5), BID(2), CASP3(5), CD244(14), CD247(1), CD48(5), FAS(4), FASLG(10), FCER1G(2), FCGR3A(9), FYN(8), GRB2(6), GZMB(6), HCST(3), HLA-A(8), HLA-B(4), HLA-C(5), HLA-E(2), HLA-G(5), HRAS(2), ICAM1(2), ICAM2(2), IFNA1(2), IFNA10(7), IFNA14(4), IFNA16(8), IFNA17(5), IFNA2(5), IFNA21(3), IFNA4(4), IFNA5(5), IFNA7(6), IFNA8(7), IFNAR1(4), IFNAR2(7), IFNB1(7), IFNG(7), IFNGR1(7), IFNGR2(4), ITGAL(26), ITGB2(8), KIR2DL3(8), KIR3DL1(17), KIR3DL2(5), KLRC1(5), KLRC2(2), KLRC3(5), KLRD1(2), KLRK1(4), LAT(4), LCK(9), LCP2(10), MAP2K1(10), MAP2K2(1), MAPK1(2), MAPK3(3), MICA(1), MICB(2), NCR1(9), NCR2(3), NCR3(1), NFAT5(13), NFATC1(9), NFATC2(15), NFATC3(15), NFATC4(11), NRAS(4), PAK1(9), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PLCG1(7), PLCG2(18), PPP3CB(3), PPP3CC(3), PPP3R1(5), PRF1(8), PRKCA(10), PRKCG(20), PTK2B(14), PTPN11(9), PTPN6(6), RAC2(2), RAF1(6), SH2D1A(3), SH2D1B(3), SH3BP2(10), SHC1(6), SHC2(5), SHC3(8), SHC4(7), SOS1(17), SOS2(13), SYK(5), TNF(2), TNFRSF10B(3), TNFRSF10C(1), TNFRSF10D(2), TNFSF10(3), TYROBP(2), ULBP1(2), ULBP2(3), ULBP3(3), VAV1(8), VAV2(8), VAV3(32), ZAP70(9)	86279270	759	323	745	231	107	293	161	71	124	3	0.193	1.000	1.000
138	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	90	ADCY1(26), ADCY2(51), ADCY3(7), ADCY4(12), ADCY5(27), ADCY6(10), ADCY7(13), ADCY8(48), ADCY9(12), AKAP1(14), AKAP10(4), AKAP11(14), AKAP12(9), AKAP2(11), AKAP3(15), AKAP4(17), AKAP5(2), AKAP6(45), AKAP7(1), AKAP8(5), AKAP9(32), ARHGEF1(5), CALM1(3), CALM2(1), CHMP1B(1), GNA11(4), GNA12(1), GNA13(6), GNA14(2), GNA15(1), GNAI3(2), GNAL(5), GNAO1(7), GNAQ(5), GNAZ(5), GNB1(2), GNB3(5), GNB5(7), GNG12(3), GNG13(5), GNG3(1), GNG4(1), GNG7(1), GNGT1(6), GNGT2(3), HRAS(2), IL18BP(1), ITPR1(20), KCNJ3(36), NRAS(4), PALM2(7), PDE1A(17), PDE1B(13), PDE1C(28), PDE4A(7), PDE4B(14), PDE4C(4), PDE4D(5), PDE7A(3), PDE7B(6), PDE8A(3), PDE8B(10), PLCB3(9), PPP3CC(3), PRKACA(3), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PRKCA(10), PRKCD(7), PRKCE(5), PRKCG(20), PRKCH(6), PRKCI(11), PRKCQ(12), PRKCZ(4), PRKD1(31), PRKD3(10), RHOA(4), RRAS(1), SLC9A1(6), USP5(8)	92682314	811	322	804	275	108	319	188	71	119	6	0.713	1.000	1.000
139	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	89	AKT1(3), AKT2(7), AKT3(7), BCL10(4), CARD11(34), CBL(10), CBLB(10), CBLC(1), CD247(1), CD28(4), CD3D(2), CD3E(2), CD4(8), CD40LG(9), CD8A(4), CD8B(5), CDC42(1), CDK4(3), CHUK(7), CTLA4(3), FOS(3), FYN(8), GRAP2(13), GRB2(6), HRAS(2), ICOS(5), IFNG(7), IKBKB(9), IL10(2), IL2(7), IL4(1), IL5(2), ITK(16), JUN(3), LAT(4), LCK(9), LCP2(10), MALT1(13), MAP3K8(4), NCK1(5), NCK2(6), NFAT5(13), NFATC1(9), NFATC2(15), NFATC3(15), NFATC4(11), NFKB1(6), NFKB2(5), NFKBIA(4), NFKBIB(3), NFKBIE(2), NRAS(4), PAK1(9), PAK2(3), PAK3(16), PAK4(6), PAK6(2), PAK7(37), PDCD1(4), PDK1(6), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PLCG1(7), PPP3CB(3), PPP3CC(3), PPP3R1(5), PRKCQ(12), PTPN6(6), PTPRC(41), RASGRP1(3), RHOA(4), SOS1(17), SOS2(13), TEC(12), TNF(2), VAV1(8), VAV2(8), VAV3(32), ZAP70(9)	78283744	693	321	680	200	107	269	130	55	130	2	0.121	1.000	1.000
140	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	81	ANPEP(10), CD14(1), CD19(5), CD1B(17), CD1C(15), CD1D(10), CD1E(27), CD2(6), CD22(16), CD33(13), CD34(13), CD36(4), CD37(2), CD38(4), CD3D(2), CD3E(2), CD4(8), CD44(7), CD5(7), CD55(3), CD8A(4), CD8B(5), CD9(3), CR1(34), CR2(20), CSF1(1), CSF1R(18), CSF2RA(8), CSF3R(6), DNTT(6), EPO(6), EPOR(2), FCER2(2), FCGR1A(5), FLT3(24), FLT3LG(2), GP5(8), HLA-DRA(3), HLA-DRB1(5), IL11RA(1), IL1A(4), IL1B(1), IL1R1(2), IL1R2(5), IL2RA(6), IL3(4), IL3RA(8), IL4(1), IL4R(10), IL5(2), IL5RA(9), IL6(2), IL6R(8), IL7(2), IL7R(21), IL9R(16), ITGA1(14), ITGA2(25), ITGA2B(12), ITGA3(8), ITGA4(38), ITGA5(11), ITGA6(12), ITGAM(24), ITGB3(13), KIT(12), KITLG(6), MME(20), MS4A1(11), TFRC(6), THPO(7), TNF(2), TPO(33)	65178047	690	306	678	230	63	288	130	69	140	0	0.807	1.000	1.000
141	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	79	ABL1(9), ATM(53), BUB1(10), BUB1B(10), BUB3(4), CCNA1(7), CCNA2(6), CCNB1(2), CCNB3(35), CCND2(4), CCND3(1), CCNE1(7), CCNE2(3), CCNH(3), CDAN1(8), CDC14A(10), CDC14B(3), CDC20(8), CDC25A(4), CDC25B(1), CDC25C(8), CDC6(4), CDC7(6), CDH1(6), CDK2(1), CDK4(3), CDKN1A(2), CHEK1(7), CHEK2(10), DTX4(2), E2F1(3), E2F2(5), E2F3(2), E2F4(5), E2F5(1), E2F6(1), EP300(11), ESPL1(6), GADD45A(2), GSK3B(4), HDAC1(4), HDAC2(8), HDAC3(3), HDAC4(19), HDAC5(5), HDAC6(12), HDAC8(1), MAD1L1(6), MAD2L1(5), MAD2L2(2), MCM2(5), MCM3(12), MCM4(11), MCM5(10), MCM6(16), MCM7(5), MDM2(5), MPEG1(12), MPL(5), PCNA(1), PLK1(9), PRKDC(50), PTPRA(11), PTTG1(2), RBL1(7), SKP2(3), SMAD4(21), TBC1D8(9), TFDP1(10), TGFB1(3), WEE1(4)	85862341	553	299	549	124	67	181	107	66	129	3	0.000945	1.000	1.000
142	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	91	ACTB(10), BCL2(5), CABIN1(10), CALM1(3), CALM2(1), CAMK2B(16), CAMK4(16), CD3E(2), CD69(2), CDKN1A(2), CNR1(15), CREBBP(30), CSNK2A1(5), CTLA4(3), EGR2(4), EGR3(1), EP300(11), FCER1A(9), FCGR3A(9), FOS(3), FOSL1(4), GATA3(12), GATA4(7), GSK3A(1), GSK3B(4), HRAS(2), ICOS(5), IFNA1(2), IFNB1(7), IFNG(7), IL10(2), IL13(2), IL1B(1), IL2(7), IL2RA(6), IL3(4), IL4(1), IL6(2), ITK(16), JUNB(1), KPNA5(4), MAP2K7(7), MAPK14(4), MAPK8(2), MAPK9(8), MEF2A(2), MEF2B(2), MEF2D(4), MYF5(12), NCK2(6), NFAT5(13), NFATC1(9), NFATC2(15), NFATC3(15), NFATC4(11), NFKB2(5), NFKBIB(3), NFKBIE(2), NPPB(3), NUP214(26), OPRD1(2), P2RX7(6), PAK1(9), PIN1(1), PPP3CB(3), PPP3CC(3), PPP3R1(5), PTPRC(41), RELA(3), RPL13A(2), SFN(1), SLA(6), SP1(6), SP3(6), TGFB1(3), TNF(2), TRAF2(5), TRPV6(25), VAV1(8), VAV2(8), VAV3(32), XPO5(6)	72801598	586	297	581	183	67	223	121	48	125	2	0.434	1.000	1.000
143	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	52	ADORA3(4), ALG6(1), CCKBR(24), CCR2(6), CCR3(4), CCR5(4), CELSR1(17), CELSR2(22), CELSR3(36), CHRM2(39), CHRM3(27), CIDEB(2), CXCR3(3), DRD4(2), EDNRA(3), EMR2(13), EMR3(10), F2R(10), FSHR(37), GHRHR(5), GNRHR(5), GPR116(11), GPR132(6), GPR133(18), GPR135(4), GPR143(2), GPR17(8), GPR18(4), GPR55(9), GPR56(6), GPR61(8), GPR84(4), GRM1(48), GRPR(7), HRH4(5), LGR6(22), LPHN2(47), LPHN3(78), NTSR1(10), OR2M4(33), P2RY11(2), P2RY13(1), PTGFR(12), SMO(17), SSTR2(4), TAAR5(11), TSHR(22), VN1R1(2)	52700176	675	297	669	208	99	272	140	67	95	2	0.0223	1.000	1.000
144	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	87	ACVR1(7), ACVR1B(11), ACVR1C(11), ACVR2A(5), ACVR2B(4), ACVRL1(11), AMHR2(6), BMP2(1), BMP4(6), BMP5(6), BMP6(8), BMP7(12), BMP8A(2), BMPR1A(4), BMPR1B(7), BMPR2(10), CHRD(13), COMP(4), CREBBP(30), CUL1(14), DCN(5), E2F4(5), E2F5(1), EP300(11), FST(5), GDF5(12), GDF6(10), GDF7(5), ID1(1), ID2(4), ID3(3), IFNG(7), INHBB(4), INHBC(4), INHBE(5), LEFTY1(7), LEFTY2(4), LTBP1(61), MAPK1(2), MAPK3(3), MYC(4), NODAL(2), NOG(1), PITX2(8), PPP2CA(1), PPP2CB(3), PPP2R1A(10), PPP2R1B(5), PPP2R2A(8), PPP2R2B(12), PPP2R2C(5), RBL1(7), RBL2(5), RHOA(4), ROCK1(19), ROCK2(9), RPS6KB1(3), RPS6KB2(3), SKP1(4), SMAD1(7), SMAD2(7), SMAD3(6), SMAD4(21), SMAD5(1), SMAD6(2), SMAD9(4), SMURF1(8), SMURF2(4), SP1(6), TFDP1(10), TGFB1(3), TGFB2(10), TGFBR1(7), TGFBR2(7), THBS1(8), THBS2(35), THBS3(5), THBS4(8), TNF(2), ZFYVE16(7), ZFYVE9(14)	78651197	626	296	623	174	101	219	134	63	108	1	0.0837	1.000	1.000
145	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	96	AKT1(3), AKT2(7), AKT3(7), CASP8(6), CCL4(2), CD14(1), CD40(3), CD80(3), CD86(11), CHUK(7), CXCL10(1), CXCL11(1), CXCL9(4), FADD(2), FOS(3), IFNA1(2), IFNA10(7), IFNA14(4), IFNA16(8), IFNA17(5), IFNA2(5), IFNA21(3), IFNA4(4), IFNA5(5), IFNA7(6), IFNA8(7), IFNAR1(4), IFNAR2(7), IFNB1(7), IKBKB(9), IKBKE(9), IL12A(2), IL12B(3), IL1B(1), IL6(2), IRAK1(6), IRAK4(4), IRF5(1), IRF7(3), JUN(3), LBP(8), LY96(3), MAP2K1(10), MAP2K2(1), MAP2K3(13), MAP2K4(8), MAP2K6(5), MAP2K7(7), MAP3K7(10), MAP3K8(4), MAPK1(2), MAPK10(6), MAPK12(2), MAPK13(1), MAPK14(4), MAPK3(3), MAPK8(2), MAPK9(8), MYD88(1), NFKB1(6), NFKB2(5), NFKBIA(4), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), RELA(3), RIPK1(11), SPP1(5), STAT1(7), TBK1(4), TICAM1(3), TLR1(9), TLR2(10), TLR3(4), TLR4(64), TLR5(8), TLR6(11), TLR7(17), TLR8(16), TLR9(9), TNF(2), TOLLIP(2), TRAF3(4), TRAF6(6)	69663644	564	295	560	186	54	219	124	68	99	0	0.701	1.000	1.000
146	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(9), AKT1(3), BDKRB2(3), CALM1(3), CALM2(1), CAV1(1), CHRM1(5), CHRNA1(16), FLT1(31), FLT4(20), KDR(56), NOS3(12), PDE2A(11), PDE3A(30), PDE3B(16), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PRKG1(20), PRKG2(15), RYR2(359), SLC7A1(5), SYT1(6), TNNI1(3)	32393146	649	288	629	183	62	297	127	63	91	9	0.0364	1.000	1.000
147	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	80	ABL1(9), ABL2(18), AKT1(3), AKT2(7), AKT3(7), ARAF(5), AREG(1), BTC(2), CAMK2A(3), CAMK2B(16), CAMK2D(7), CBL(10), CBLB(10), CBLC(1), CDKN1A(2), CDKN1B(5), CRK(1), CRKL(4), EGF(13), ELK1(3), ERBB2(12), ERBB3(11), ERBB4(51), EREG(4), GAB1(7), GRB2(6), GSK3B(4), HRAS(2), JUN(3), MAP2K1(10), MAP2K2(1), MAP2K4(8), MAP2K7(7), MAPK1(2), MAPK10(6), MAPK3(3), MAPK8(2), MAPK9(8), MYC(4), NCK1(5), NCK2(6), NRAS(4), NRG1(18), NRG2(3), NRG4(1), PAK1(9), PAK2(3), PAK3(16), PAK4(6), PAK6(2), PAK7(37), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PLCG1(7), PLCG2(18), PRKCA(10), PRKCG(20), PTK2(6), RAF1(6), RPS6KB1(3), RPS6KB2(3), SHC1(6), SHC2(5), SHC3(8), SHC4(7), SOS1(17), SOS2(13), SRC(2), STAT5A(3), STAT5B(8), TGFA(1)	75744627	609	282	587	194	95	226	117	59	111	1	0.536	1.000	1.000
148	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	60	AKT1(3), AKT2(7), AKT3(7), BCL2L1(3), CDC42(1), CDK2(1), CDKN1B(5), CREB1(2), CREB5(18), EBP(3), ERBB4(51), F2RL2(12), GAB1(7), GADD45A(2), GRB2(6), GSK3A(1), GSK3B(4), IFI27(1), IGF1(4), IGFBP1(6), INPPL1(11), IRS1(20), IRS4(34), MET(22), MYC(4), NOLC1(5), PAK1(9), PAK2(3), PAK3(16), PAK4(6), PAK6(2), PAK7(37), PARD3(15), PARD6A(1), PDK1(6), PIK3CD(4), PPP1R13B(7), PREX1(40), PTEN(11), PTK2(6), PTPN1(3), RPS6KA1(6), RPS6KA2(8), RPS6KA3(6), RPS6KB1(3), SFN(1), SHC1(6), SLC2A4(4), SOS1(17), SOS2(13), TSC1(10), TSC2(13), YWHAB(1), YWHAE(1), YWHAG(3), YWHAH(1), YWHAQ(4), YWHAZ(2)	58977303	505	273	495	128	69	207	96	34	99	0	0.00927	1.000	1.000
149	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR1(9), AGTR2(6), ATP8A1(7), AVPR1A(14), AVPR1B(7), AVPR2(7), BDKRB1(1), BDKRB2(3), BRS3(8), C3AR1(11), CCKAR(14), CCKBR(24), CCR1(3), CCR10(1), CCR2(6), CCR3(4), CCR4(3), CCR5(4), CCR6(9), CCR8(6), CX3CR1(11), CXCR3(3), CXCR4(6), CXCR6(2), EDNRA(3), EDNRB(16), FPR1(10), FSHR(37), GALR1(8), GALR2(3), GALR3(1), GALT(5), GHSR(5), GNB2L1(3), GNRHR(5), GRPR(7), LHCGR(14), MC1R(2), MC2R(12), MC3R(16), MC4R(3), MC5R(22), NMBR(8), NPY1R(17), NPY2R(20), NPY5R(22), NTSR1(10), NTSR2(6), OPRD1(2), OPRK1(12), OPRL1(14), OPRM1(12), OXTR(4), SSTR1(9), SSTR2(4), SSTR3(8), SSTR4(15), TAC4(1), TACR1(4), TACR2(2), TACR3(15), TRHR(14), TSHR(22)	42039386	562	266	554	217	89	233	122	53	64	1	0.475	1.000	1.000
150	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	59	AKT1(3), AKT2(7), AKT3(7), BCL10(4), BLNK(2), BTK(25), CARD11(34), CD19(5), CD22(16), CD72(2), CD79A(2), CD79B(2), CD81(1), CHUK(7), CR2(20), FCGR2B(7), FOS(3), GSK3B(4), HRAS(2), IFITM1(2), IKBKB(9), INPP5D(11), JUN(3), LILRB3(7), LYN(6), MALT1(13), NFAT5(13), NFATC1(9), NFATC2(15), NFATC3(15), NFATC4(11), NFKB1(6), NFKB2(5), NFKBIA(4), NFKBIB(3), NFKBIE(2), NRAS(4), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PLCG2(18), PPP3CB(3), PPP3CC(3), PPP3R1(5), PTPN6(6), RAC2(2), RASGRP3(11), SYK(5), VAV1(8), VAV2(8), VAV3(32)	56529664	470	265	464	154	60	181	108	39	81	1	0.546	1.000	1.000
151	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	68	ACACB(28), ACSL1(12), ACSL3(4), ACSL4(7), ACSL5(3), ACSL6(15), ADIPOQ(6), ADIPOR1(6), ADIPOR2(3), AKT1(3), AKT2(7), AKT3(7), CAMKK1(4), CAMKK2(3), CD36(4), CHUK(7), CPT1A(11), CPT1B(6), CPT1C(13), CPT2(3), G6PC(7), G6PC2(8), IKBKB(9), IRS1(20), IRS4(34), JAK1(11), JAK2(16), JAK3(10), LEP(4), LEPR(26), MAPK10(6), MAPK8(2), MAPK9(8), NFKB1(6), NFKB2(5), NFKBIA(4), NFKBIB(3), NFKBIE(2), NPY(4), PCK1(21), PCK2(4), POMC(4), PPARA(4), PPARGC1A(23), PRKAA1(6), PRKAA2(8), PRKAB1(3), PRKAG1(1), PRKAG2(5), PRKAG3(8), PRKCQ(12), PTPN11(9), RELA(3), RXRA(1), RXRB(3), RXRG(18), SLC2A1(1), SLC2A4(4), STAT3(11), TNF(2), TNFRSF1B(2), TRADD(2), TRAF2(5), TYK2(5)	65365026	502	265	499	179	65	186	100	57	94	0	0.881	1.000	1.000
152	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	54	ASH1L(33), ASH2L(2), CARM1(4), CTCFL(21), DOT1L(14), EED(8), EHMT1(15), EHMT2(9), EZH1(4), EZH2(11), FBXO11(5), HCFC1(24), HSF4(1), JMJD4(3), JMJD6(3), KDM6A(12), MEN1(6), NSD1(23), OGT(19), PAXIP1(7), PPP1CA(2), PPP1CB(4), PPP1CC(1), PRDM2(21), PRDM7(6), PRDM9(82), PRMT5(7), PRMT6(7), PRMT7(4), PRMT8(13), RBBP5(3), SATB1(10), SETD1A(18), SETD7(2), SETD8(1), SETDB1(11), SETDB2(13), SETMAR(5), SMYD3(10), STK38(3), SUV39H1(1), SUV39H2(4), SUV420H1(16), WHSC1(12), WHSC1L1(8)	91640318	488	261	482	146	54	197	117	42	75	3	0.657	1.000	1.000
153	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	83	ATF2(10), CHUK(7), CREB1(2), DAXX(8), ELK1(3), FOS(3), GRB2(6), HRAS(2), IKBKB(9), JUN(3), MAP2K1(10), MAP2K2(1), MAP2K3(13), MAP2K4(8), MAP2K5(4), MAP2K6(5), MAP2K7(7), MAP3K1(7), MAP3K10(4), MAP3K11(5), MAP3K12(10), MAP3K13(12), MAP3K2(6), MAP3K3(10), MAP3K4(21), MAP3K5(14), MAP3K6(4), MAP3K7(10), MAP3K8(4), MAP3K9(17), MAP4K1(12), MAP4K2(4), MAP4K3(12), MAP4K4(8), MAP4K5(2), MAPK1(2), MAPK10(6), MAPK12(2), MAPK13(1), MAPK14(4), MAPK3(3), MAPK4(9), MAPK6(4), MAPK7(7), MAPK8(2), MAPK9(8), MAPKAPK2(2), MAPKAPK3(3), MAPKAPK5(5), MAX(8), MEF2A(2), MEF2B(2), MEF2C(6), MEF2D(4), MKNK1(4), MKNK2(2), MYC(4), NFKB1(6), NFKBIA(4), PAK1(9), PAK2(3), RAF1(6), RELA(3), RIPK1(11), RPS6KA1(6), RPS6KA2(8), RPS6KA3(6), RPS6KA4(4), RPS6KA5(10), RPS6KB1(3), RPS6KB2(3), SHC1(6), SP1(6), STAT1(7), TGFB1(3), TGFB2(10), TGFBR1(7), TRADD(2), TRAF2(5)	74693043	481	258	475	136	55	170	95	44	117	0	0.262	1.000	1.000
154	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	46	FN3K(1), IMPA1(1), IMPA2(1), INPP1(8), INPP4A(7), INPP4B(27), INPP5A(3), INPP5B(10), INPP5E(2), INPPL1(11), IPMK(11), ISYNA1(1), ITPK1(1), ITPKA(2), ITPKB(7), MINPP1(3), MIOX(2), OCRL(13), PI4KA(17), PI4KB(10), PIK3C3(14), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIP4K2A(7), PIP4K2B(3), PIP4K2C(7), PIP5K1A(6), PIP5K1B(6), PIP5K1C(4), PLCB1(52), PLCB2(12), PLCB3(9), PLCB4(35), PLCD1(4), PLCD3(2), PLCD4(7), PLCE1(28), PLCG1(7), PLCG2(18), PLCZ1(8), PTEN(11), PTPMT1(1), SYNJ1(14), SYNJ2(9)	57481010	447	256	443	134	55	168	106	38	78	2	0.256	1.000	1.000
155	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(21), AMY2A(6), AMY2B(11), ENPP1(14), ENPP3(19), G6PC(7), GAA(12), GANAB(9), GBE1(8), GCK(6), GPI(8), GUSB(5), GYS1(4), GYS2(8), HK1(12), HK2(11), HK3(22), MGAM(51), PGM1(3), PGM3(3), PYGB(5), PYGL(6), PYGM(9), RNPC3(1), SI(117), UCHL1(4), UCHL3(1), UGDH(6), UGT1A1(12), UGT1A10(9), UGT1A3(6), UGT1A4(4), UGT1A5(8), UGT1A6(9), UGT1A7(7), UGT1A9(7), UGT2B15(14), UGT2B4(28), UXS1(6)	45835022	499	251	495	132	58	224	102	42	73	0	0.0372	1.000	1.000
156	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	90	CD2BP2(5), CDC40(4), CLK2(10), CLK3(2), CLK4(4), COL2A1(24), CPSF1(14), CPSF2(8), CPSF3(6), CSTF1(7), CSTF2(3), CSTF2T(7), CSTF3(7), DDIT3(2), DDX1(9), DDX20(4), DHX15(7), DHX16(7), DHX38(9), DHX8(14), DHX9(12), DICER1(15), DNAJC8(4), FUS(5), GIPC1(6), LSM2(1), LSM7(2), METTL3(3), NCBP1(3), NCBP2(3), NONO(6), NXF1(11), PABPN1(5), PAPOLA(11), POLR2A(11), PPM1G(6), PRPF18(3), PRPF3(5), PRPF4(3), PRPF4B(11), PRPF8(10), PSKH1(3), PTBP1(4), PTBP2(9), RBM17(4), RBM5(6), RNGTT(10), RNMT(8), RNPS1(1), SF3A1(10), SF3A2(1), SF3A3(2), SF3B1(15), SF3B2(14), SF3B4(8), SF3B5(3), SNRPA(1), SNRPA1(1), SNRPB(3), SNRPB2(1), SNRPD1(2), SNRPE(1), SNRPG(2), SNRPN(15), SNURF(2), SPOP(4), SRPK1(5), SRPK2(6), SRRM1(4), SUPT5H(9), U2AF2(6), XRN2(8)	84401454	457	249	453	126	70	148	98	53	88	0	0.330	1.000	1.000
157	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	72	AKT1(3), AKT2(7), AKT3(7), BTK(25), FCER1A(9), FCER1G(2), FYN(8), GAB2(7), GRB2(6), HRAS(2), IL13(2), IL3(4), IL4(1), IL5(2), INPP5D(11), LAT(4), LCP2(10), LYN(6), MAP2K1(10), MAP2K2(1), MAP2K3(13), MAP2K4(8), MAP2K6(5), MAP2K7(7), MAPK1(2), MAPK10(6), MAPK12(2), MAPK13(1), MAPK14(4), MAPK3(3), MAPK8(2), MAPK9(8), MS4A2(7), NRAS(4), PDK1(6), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PLA2G12A(4), PLA2G12B(3), PLA2G1B(2), PLA2G2A(5), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(6), PLA2G4A(21), PLA2G6(3), PLCG1(7), PLCG2(18), PRKCA(10), PRKCD(7), PRKCE(5), RAC2(2), RAF1(6), SOS1(17), SOS2(13), SYK(5), TNF(2), VAV1(8), VAV2(8), VAV3(32)	55364096	473	247	464	145	61	176	110	37	87	2	0.353	1.000	1.000
158	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	66	AKT1(3), AKT2(7), AKT3(7), CASP9(6), CDC42(1), HRAS(2), KDR(56), MAP2K1(10), MAP2K2(1), MAPK1(2), MAPK12(2), MAPK13(1), MAPK14(4), MAPK3(3), MAPKAPK2(2), MAPKAPK3(3), NFAT5(13), NFATC1(9), NFATC2(15), NFATC3(15), NFATC4(11), NOS3(12), NRAS(4), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PLA2G12A(4), PLA2G12B(3), PLA2G1B(2), PLA2G2A(5), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(6), PLA2G4A(21), PLA2G6(3), PLCG1(7), PLCG2(18), PPP3CB(3), PPP3CC(3), PPP3R1(5), PRKCA(10), PRKCG(20), PTGS2(12), PTK2(6), PXN(1), RAC2(2), RAF1(6), SH2D2A(10), SHC2(5), SPHK2(4), SRC(2), VEGFA(1)	54113477	432	246	422	156	60	175	96	48	52	1	0.793	1.000	1.000
159	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	43	ACTR2(4), ACTR3(2), AKT1(3), AKT2(7), AKT3(7), ANGPTL2(5), ARHGAP1(5), ARHGAP4(14), ARHGEF11(24), BTK(25), CDC42(1), CFL2(3), GDI1(6), GDI2(1), INPPL1(11), ITPR1(20), ITPR2(40), ITPR3(21), LIMK1(3), MYLK(26), MYLK2(9), PAK1(9), PAK2(3), PAK3(16), PAK4(6), PAK6(2), PAK7(37), PDK1(6), PIK3CD(4), PIK3CG(33), PIK3R1(4), PITX2(8), PPP1R13B(7), PTEN(11), RACGAP1(7), RHO(7), ROCK1(19), ROCK2(9), RPS4X(2), SAG(5), WASF1(10), WASL(7)	54553546	449	246	442	125	71	163	88	34	93	0	0.0649	1.000	1.000
160	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP2(1), BMP4(6), BMP5(6), BMP6(8), BMP7(12), BMP8A(2), BTRC(12), CSNK1A1(2), CSNK1A1L(14), CSNK1D(7), CSNK1E(6), CSNK1G1(4), CSNK1G2(2), CSNK1G3(8), DHH(2), FBXW11(2), GLI1(17), GLI2(28), GLI3(39), GSK3B(4), HHIP(4), IHH(3), LRP2(88), PRKACA(3), PRKACB(9), PRKACG(4), PRKX(3), PTCH1(16), PTCH2(8), RAB23(1), SHH(2), SMO(17), STK36(12), SUFU(2), WNT1(6), WNT10A(10), WNT10B(10), WNT11(6), WNT16(9), WNT2(7), WNT2B(4), WNT3A(10), WNT4(1), WNT5A(2), WNT5B(6), WNT7A(14), WNT7B(4), WNT8A(9), WNT8B(8), WNT9A(6), WNT9B(6), ZIC2(3)	48461340	475	245	468	135	96	190	101	33	55	0	0.0389	1.000	1.000
161	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	85	AICDA(3), CAD(25), CANT1(3), CDA(2), CTPS2(6), DCK(2), DCTD(4), DHODH(1), DPYD(24), DPYS(22), ENTPD1(7), ENTPD4(4), ENTPD5(1), ENTPD6(6), ENTPD8(1), ITPA(1), NME6(3), NME7(4), NT5C1A(12), NT5C1B(11), NT5C2(3), NT5E(5), NT5M(3), NUDT2(3), PNPT1(12), POLA1(19), POLA2(7), POLD1(7), POLD2(3), POLD3(2), POLD4(2), POLE(31), POLE2(1), POLE4(1), POLR1A(13), POLR1B(11), POLR1D(2), POLR2A(11), POLR2B(10), POLR2C(4), POLR2D(3), POLR2E(2), POLR2F(1), POLR2G(1), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(2), POLR3A(17), POLR3B(20), POLR3G(2), POLR3H(1), POLR3K(2), PRIM1(3), RFC5(3), RRM1(6), RRM2(6), RRM2B(3), TK1(1), TK2(1), TXNRD1(7), TXNRD2(2), TYMS(3), UCK2(10), UMPS(4), UPB1(2), UPP1(6), UPP2(6), UPRT(5), ZNRD1(1)	64305375	416	244	415	121	51	160	99	38	66	2	0.301	1.000	1.000
162	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	77	AIFM1(16), AKT1(3), AKT2(7), AKT3(7), APAF1(10), ATM(53), BAX(3), BCL2(5), BCL2L1(3), BID(2), BIRC2(2), BIRC3(4), CAPN1(2), CAPN2(5), CASP10(7), CASP3(5), CASP6(3), CASP7(3), CASP8(6), CASP9(6), CFLAR(2), CHUK(7), CSF2RB(14), CYCS(2), DFFA(3), DFFB(4), FADD(2), FAS(4), FASLG(10), IKBKB(9), IL1A(4), IL1B(1), IL1R1(2), IL1RAP(4), IL3(4), IL3RA(8), IRAK1(6), IRAK2(6), IRAK3(6), IRAK4(4), MYD88(1), NFKB1(6), NFKB2(5), NFKBIA(4), NTRK1(14), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PPP3CB(3), PPP3CC(3), PPP3R1(5), PRKACA(3), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), RELA(3), RIPK1(11), TNF(2), TNFRSF10B(3), TNFRSF10C(1), TNFRSF10D(2), TNFSF10(3), TRADD(2), TRAF2(5)	63540108	432	244	428	146	51	155	98	53	71	4	0.849	1.000	1.000
163	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	47	ADCY4(12), ADCY6(10), ADCY8(48), CACNA1A(32), CACNA1B(39), GNAS(29), GNAT3(6), GNB1(2), GNB3(5), GNG13(5), GNG3(1), GRM4(21), ITPR3(21), KCNB1(28), PDE1A(17), PLCB2(12), PRKACA(3), PRKACB(9), PRKACG(4), PRKX(3), SCNN1A(2), SCNN1B(6), SCNN1G(8), TAS1R1(5), TAS1R2(28), TAS1R3(6), TAS2R10(2), TAS2R13(2), TAS2R14(4), TAS2R16(15), TAS2R3(2), TAS2R38(9), TAS2R39(5), TAS2R4(3), TAS2R40(7), TAS2R41(15), TAS2R42(2), TAS2R43(1), TAS2R46(5), TAS2R5(3), TAS2R50(1), TAS2R60(9), TAS2R7(3), TAS2R9(3), TRPM5(11)	44672020	464	242	456	163	85	182	114	29	54	0	0.279	1.000	1.000
164	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	53	AKR1C4(4), AKR1D1(12), ARSD(6), ARSE(5), CARM1(4), CYP11B1(27), CYP11B2(24), CYP19A1(4), HSD11B1(9), HSD17B1(2), HSD17B12(4), HSD17B2(6), HSD17B3(3), HSD17B7(3), HSD3B1(6), HSD3B2(15), LCMT1(5), LCMT2(7), METTL2B(5), METTL6(1), PRMT2(2), PRMT3(8), PRMT5(7), PRMT6(7), PRMT7(4), PRMT8(13), SRD5A1(4), STS(9), SULT1E1(11), SULT2A1(6), SULT2B1(2), UGT1A1(12), UGT1A10(9), UGT1A3(6), UGT1A4(4), UGT1A5(8), UGT1A6(9), UGT1A7(7), UGT1A9(7), UGT2A1(16), UGT2A3(11), UGT2B10(9), UGT2B11(23), UGT2B15(14), UGT2B17(12), UGT2B4(28), UGT2B7(14), WBSCR22(3)	39787126	417	240	411	121	40	183	100	39	54	1	0.164	1.000	1.000
165	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACADL(4), ACADM(8), ACOX1(5), ACOX2(3), ACOX3(8), ACSL1(12), ACSL3(4), ACSL4(7), ACSL5(3), ACSL6(15), ADIPOQ(6), ANGPTL4(2), APOA1(3), APOA2(1), APOA5(10), APOC3(2), AQP7(7), CD36(4), CPT1A(11), CPT1B(6), CPT1C(13), CPT2(3), CYP27A1(5), CYP4A11(8), CYP4A22(1), CYP7A1(8), CYP8B1(4), EHHADH(13), FABP2(1), FABP3(4), FABP4(2), FABP5(1), FABP6(3), FABP7(2), FADS2(4), GK(7), GK2(10), HMGCS2(7), ILK(1), LPL(8), ME1(3), MMP1(11), NR1H3(4), OLR1(8), PCK1(21), PCK2(4), PDPK1(3), PLTP(7), PPARA(4), PPARD(6), PPARG(8), RXRA(1), RXRB(3), RXRG(18), SCD(3), SCP2(4), SLC27A1(4), SLC27A2(4), SLC27A4(4), SLC27A5(7), SLC27A6(24), SORBS1(12), UBC(14), UCP1(3)	52667188	406	234	404	122	51	159	79	50	67	0	0.292	1.000	1.000
166	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(36), COL4A2(40), COL4A3(16), COL4A4(22), COL4A5(50), COL4A6(28), F10(5), F11(13), F12(4), F2(9), F2R(10), F5(40), F8(56), F9(20), FGA(20), FGB(18), FGG(4), KLKB1(6), PROC(4), PROS1(30), SERPINC1(5), SERPING1(7)	35804097	443	234	440	122	32	230	77	32	71	1	0.437	1.000	1.000
167	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	44	AKT1(3), AKT2(7), AKT3(7), BCL2(5), BCR(11), BLNK(2), BTK(25), CD19(5), CD22(16), CD81(1), CR2(20), CSK(2), DAG1(3), FLOT1(1), FLOT2(4), GRB2(6), GSK3A(1), GSK3B(4), INPP5D(11), ITPR1(20), ITPR2(40), ITPR3(21), LYN(6), MAP4K1(12), MAPK1(2), MAPK3(3), NFATC1(9), NFATC2(15), NR0B2(3), PDK1(6), PIK3CD(4), PIK3R1(4), PLCG2(18), PPP1R13B(7), PPP3CB(3), PPP3CC(3), PTPRC(41), RAF1(6), SHC1(6), SOS1(17), SOS2(13), SYK(5), VAV1(8)	56687142	406	233	400	138	53	143	98	29	83	0	0.709	1.000	1.000
168	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG1(6), ACTG2(10), ACTR2(4), ACTR3(2), AKT1(3), ANGPTL2(5), CDC42(1), CFL2(3), FLNA(31), FLNC(55), FSCN1(4), FSCN2(1), FSCN3(14), GDI1(6), GDI2(1), LIMK1(3), MYH2(77), MYLK(26), MYLK2(9), PAK1(9), PAK2(3), PAK3(16), PAK4(6), PAK6(2), PAK7(37), PFN1(1), PFN2(1), RHO(7), ROCK1(19), ROCK2(9), RPS4X(2), VASP(2), WASF1(10), WASL(7)	38011947	392	233	384	132	55	161	69	41	66	0	0.450	1.000	1.000
169	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	54	ADH1A(8), ADH1B(12), ADH4(4), ADH5(2), ADH6(8), ADH7(11), ADHFE1(5), AGK(6), AGPAT1(9), AGPAT2(3), AGPAT3(4), AGPAT4(9), AGPAT6(5), AKR1A1(1), AKR1B1(7), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH7A1(3), ALDH9A1(3), CEL(8), DAK(4), DGAT1(1), DGKA(7), DGKB(40), DGKD(10), DGKE(5), DGKG(15), DGKH(14), DGKI(35), DGKQ(1), DGKZ(5), GK(7), GK2(10), GLA(9), GLB1(3), GPAM(6), LCT(50), LIPA(2), LIPC(9), LIPF(8), LIPG(11), LPL(8), MGLL(2), PNLIPRP1(14), PNPLA3(4), PPAP2A(2), PPAP2B(3), PPAP2C(1)	46126752	424	231	416	119	51	174	91	36	71	1	0.0768	1.000	1.000
170	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	68	ADH1A(8), ADH1B(12), ADH4(4), ADH5(2), ADH6(8), ADH7(11), ADHFE1(5), AKR1C1(4), AKR1C2(2), AKR1C3(5), AKR1C4(4), ALDH1A3(4), ALDH3A1(5), ALDH3B1(2), ALDH3B2(4), CYP1A1(9), CYP1A2(3), CYP1B1(5), CYP2B6(10), CYP2C18(7), CYP2C19(13), CYP2C8(2), CYP2C9(8), CYP2E1(7), CYP2F1(3), CYP2S1(3), CYP3A4(4), CYP3A43(3), CYP3A5(5), CYP3A7(7), DHDH(3), EPHX1(7), GSTA1(7), GSTA2(7), GSTA3(2), GSTA4(2), GSTA5(6), GSTK1(1), GSTM1(1), GSTM2(4), GSTM3(2), GSTM4(1), GSTM5(3), GSTO2(3), GSTP1(2), GSTT1(1), GSTZ1(2), MGST1(1), MGST2(2), MGST3(2), UGT1A1(12), UGT1A10(9), UGT1A3(6), UGT1A4(4), UGT1A5(8), UGT1A6(9), UGT1A7(7), UGT1A9(7), UGT2A1(16), UGT2A3(11), UGT2B10(9), UGT2B11(23), UGT2B15(14), UGT2B17(12), UGT2B4(28), UGT2B7(14)	45607203	417	231	412	120	37	187	89	33	71	0	0.148	1.000	1.000
171	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	62	APAF1(10), ATM(53), ATR(26), BAI1(24), BAX(3), BID(2), CASP3(5), CASP8(6), CASP9(6), CCNB1(2), CCNB3(35), CCND1(3), CCND2(4), CCND3(1), CCNE1(7), CCNE2(3), CCNG1(2), CCNG2(1), CD82(5), CDK2(1), CDK4(3), CDK6(5), CDKN1A(2), CHEK1(7), CHEK2(10), CYCS(2), DDB2(2), EI24(1), FAS(4), GADD45A(2), GADD45B(1), GADD45G(1), GTSE1(6), IGF1(4), IGFBP3(4), MDM2(5), MDM4(4), PERP(1), PPM1D(8), PTEN(11), RCHY1(2), RFWD2(16), RRM2(6), RRM2B(3), SERPINB5(8), SERPINE1(14), SESN1(1), SESN2(5), SESN3(2), SFN(1), SIAH1(1), STEAP3(1), THBS1(8), TNFRSF10B(3), TP53I3(2), TP73(7), TSC2(13), ZMAT3(5)	50895338	380	229	376	84	36	135	80	45	80	4	0.00880	1.000	1.000
172	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	31	AKT1(3), AKT2(7), AKT3(7), ASAH1(3), DAG1(3), EPHB2(10), GRB2(6), ITPKA(2), ITPKB(7), ITPR1(20), ITPR2(40), ITPR3(21), KCNJ3(36), KCNJ5(10), KCNJ9(2), MAPK1(2), PI3(1), PIK3CB(8), PITX2(8), PLCB1(52), PLCB2(12), PLCB3(9), PLCB4(35), RAF1(6), RGS20(8), SHC1(6), SOS1(17), SOS2(13), SRC(2), STAT3(11)	42892749	367	228	358	109	42	146	86	32	61	0	0.330	1.000	1.000
173	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	61	ATM(53), CCNA1(7), CCNB1(2), CCND1(3), CCND2(4), CCND3(1), CCNE1(7), CCNE2(3), CCNG2(1), CCNH(3), CDC25A(4), CDK2(1), CDK4(3), CDK7(3), CDKN1A(2), CDKN1B(5), CDKN2D(2), CREB3L1(4), CREB3L3(3), CREB3L4(2), E2F1(3), E2F2(5), E2F3(2), E2F4(5), E2F5(1), E2F6(1), GADD45A(2), GBA2(5), MCM2(5), MCM3(12), MCM4(11), MCM5(10), MCM6(16), MCM7(5), MDM2(5), MNAT1(2), MYC(4), MYT1(24), NACA(15), PCNA(1), POLA2(7), POLE(31), POLE2(1), PRIM1(3), RBL1(7), RPA1(2), RPA2(2), RPA3(1), TFDP1(10), TFDP2(7), TNXB(32), WEE1(4)	59306052	354	226	350	92	49	124	63	38	77	3	0.0701	1.000	1.000
174	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	25	CPEB1(12), ERBB2(12), ERBB4(51), ETS1(8), ETS2(6), ETV6(5), ETV7(2), FMN2(65), GRB2(6), MAP2K1(10), MAPK1(2), MAPK3(3), NOTCH1(26), NOTCH2(26), NOTCH3(11), NOTCH4(53), PIWIL1(17), PIWIL2(10), PIWIL3(9), PIWIL4(7), RAF1(6), SOS1(17), SOS2(13), SPIRE1(5), SPIRE2(5)	37790621	387	226	374	96	47	158	76	35	69	2	0.0351	1.000	1.000
175	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	ADAM17(8), APH1A(3), CREBBP(30), CTBP1(2), DLL1(5), DLL3(6), DLL4(2), DTX1(10), DTX2(6), DTX3(6), DTX3L(3), DTX4(2), DVL1(5), DVL2(7), DVL3(13), EP300(11), HDAC1(4), HDAC2(8), HES1(2), JAG1(16), JAG2(7), LFNG(3), MAML1(9), MAML2(10), MAML3(9), MFNG(1), NCOR2(30), NCSTN(13), NOTCH1(26), NOTCH2(26), NOTCH3(11), NOTCH4(53), NUMB(3), NUMBL(3), PSEN1(6), PSEN2(9), PSENEN(2), PTCRA(8), RBPJ(3), RBPJL(5), RFNG(1), SNW1(3)	54216501	390	224	389	114	63	143	81	38	64	1	0.147	1.000	1.000
176	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ABL1(9), ACTB(10), ACTG1(6), ARHGEF2(8), ARPC5(1), CD14(1), CDC42(1), CDH1(6), CLDN1(1), CTTN(6), EZR(3), FYN(8), HCLS1(17), ITGB1(6), LY96(3), NCK1(5), NCK2(6), NCL(10), OCLN(1), PRKCA(10), RHOA(4), ROCK1(19), ROCK2(9), TLR4(64), TLR5(8), TUBA1A(4), TUBA1B(3), TUBA1C(4), TUBA3C(28), TUBA3D(13), TUBA3E(9), TUBA4A(3), TUBA8(1), TUBAL3(3), TUBB(2), TUBB1(6), TUBB2A(3), TUBB2B(4), TUBB3(3), TUBB6(3), TUBB8(17), WAS(8), WASL(7), YWHAQ(4), YWHAZ(2)	40961771	349	223	346	106	42	141	66	40	60	0	0.272	1.000	1.000
177	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ABL1(9), ACTB(10), ACTG1(6), ARHGEF2(8), ARPC5(1), CD14(1), CDC42(1), CDH1(6), CLDN1(1), CTTN(6), EZR(3), FYN(8), HCLS1(17), ITGB1(6), LY96(3), NCK1(5), NCK2(6), NCL(10), OCLN(1), PRKCA(10), RHOA(4), ROCK1(19), ROCK2(9), TLR4(64), TLR5(8), TUBA1A(4), TUBA1B(3), TUBA1C(4), TUBA3C(28), TUBA3D(13), TUBA3E(9), TUBA4A(3), TUBA8(1), TUBAL3(3), TUBB(2), TUBB1(6), TUBB2A(3), TUBB2B(4), TUBB3(3), TUBB6(3), TUBB8(17), WAS(8), WASL(7), YWHAQ(4), YWHAZ(2)	40961771	349	223	346	106	42	141	66	40	60	0	0.272	1.000	1.000
178	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(5), ACSS2(4), ACYP2(1), ADH1A(8), ADH1B(12), ADH4(4), ADH5(2), ADH6(8), ADH7(11), ADHFE1(5), AKR1A1(1), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH3B1(2), ALDH3B2(4), ALDH7A1(3), ALDH9A1(3), ALDOA(4), ALDOB(8), ALDOC(2), BPGM(6), DLAT(10), DLD(9), ENO1(7), ENO2(2), ENO3(3), FBP1(2), FBP2(2), G6PC(7), G6PC2(8), GALM(2), GAPDH(5), GAPDHS(10), GCK(6), GPI(8), HK1(12), HK2(11), HK3(22), LDHA(10), LDHAL6A(1), LDHAL6B(3), LDHB(4), LDHC(6), PDHA1(5), PDHA2(29), PFKL(9), PFKM(7), PFKP(5), PGAM1(1), PGAM2(1), PGAM4(6), PGK1(4), PGK2(27), PGM1(3), PGM3(3), PKLR(16), TPI1(9)	46692040	398	221	393	118	58	163	74	37	66	0	0.133	1.000	1.000
179	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	49	ACTA1(9), AGT(4), AKT1(3), CALM1(3), CALM2(1), CALR(2), CAMK1(1), CAMK1G(2), CAMK4(16), CREBBP(30), CSNK1A1(2), EDN1(1), ELSPBP1(8), F2(9), GATA4(7), GSK3B(4), HAND1(5), HAND2(10), HRAS(2), IGF1(4), LIF(3), MAP2K1(10), MAPK1(2), MAPK14(4), MAPK3(3), MAPK8(2), MEF2C(6), MYH2(77), NFATC1(9), NFATC2(15), NFATC3(15), NFATC4(11), NKX2-5(8), NPPA(3), PIK3R1(4), PPP3CB(3), PPP3CC(3), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), RAF1(6), RPS6KB1(3), SYT1(6)	38097920	340	220	335	96	55	137	72	23	52	1	0.0897	1.000	1.000
180	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	57	APC(33), AXIN1(7), CCND1(3), CCND2(4), CCND3(1), CSNK1E(6), DVL1(5), DVL2(7), DVL3(13), FBXW2(4), FOSL1(4), FZD1(6), FZD10(26), FZD2(8), FZD3(2), FZD5(5), FZD6(3), FZD7(7), FZD8(6), FZD9(4), GSK3B(4), JUN(3), LDLR(9), MAPK10(6), MAPK9(8), MYC(4), PAFAH1B1(1), PPP2R5C(1), PPP2R5E(5), PRKCA(10), PRKCD(7), PRKCE(5), PRKCG(20), PRKCH(6), PRKCI(11), PRKCQ(12), PRKCZ(4), PRKD1(31), RHOA(4), SFRP4(7), TCF7(3), WNT1(6), WNT10A(10), WNT10B(10), WNT11(6), WNT16(9), WNT2(7), WNT2B(4), WNT4(1), WNT5A(2), WNT5B(6), WNT7A(14), WNT7B(4)	46533066	394	219	389	108	87	139	69	28	69	2	0.0274	1.000	1.000
181	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	64	ADAM10(9), ADAM17(8), ATP6AP1(3), ATP6V0A1(6), ATP6V0A2(4), ATP6V0A4(8), ATP6V0B(2), ATP6V0C(4), ATP6V0D1(2), ATP6V0D2(8), ATP6V1A(6), ATP6V1B1(3), ATP6V1B2(5), ATP6V1C1(7), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1E2(5), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3), CASP3(5), CDC42(1), CHUK(7), CSK(2), CXCL1(1), F11R(3), GIT1(3), IGSF5(6), IKBKB(9), JAM2(9), JAM3(4), JUN(3), LYN(6), MAP2K4(8), MAPK10(6), MAPK12(2), MAPK13(1), MAPK14(4), MAPK8(2), MAPK9(8), MET(22), NFKB1(6), NFKB2(5), NFKBIA(4), NOD1(7), PAK1(9), PLCG1(7), PLCG2(18), PTPN11(9), PTPRZ1(72), RELA(3), SRC(2), TCIRG1(2), TJP1(15)	54282091	364	218	356	124	41	123	70	38	91	1	0.852	1.000	1.000
182	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	57	ALG2(3), BAK1(3), BAX(3), BFAR(5), BTK(25), CAD(25), CASP10(7), CASP3(5), CASP8(6), CSNK1A1(2), DAXX(8), DEDD(2), DEDD2(3), DFFA(3), DIABLO(1), EPHB2(10), FADD(2), FAF1(10), FAIM2(6), HSPB1(1), IL1A(4), MAP2K4(8), MAP2K7(7), MAP3K1(7), MAP3K5(14), MAPK1(2), MAPK10(6), MAPK8(2), MAPK8IP1(4), MAPK8IP2(2), MAPK8IP3(7), MAPK9(8), MET(22), NFAT5(13), NFKB1(6), NFKB2(5), NFKBIA(4), NFKBIB(3), NFKBIE(2), NFKBIL1(1), NR0B2(3), PFN1(1), PFN2(1), PTPN13(21), RALBP1(3), RIPK1(11), ROCK1(19), SMPD1(3), TNFRSF6B(1), TPX2(12), TRAF2(5)	55195316	337	218	334	94	32	125	72	37	70	1	0.209	1.000	1.000
183	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	ADRB1(1), AKT1(3), APC(33), ASAH1(3), CAMP(4), CAV3(3), DAG1(3), DLG4(7), EPHB2(10), GNAI1(10), GNAQ(5), ITPR1(20), ITPR2(40), ITPR3(21), KCNJ3(36), KCNJ5(10), KCNJ9(2), MAPK1(2), PITX2(8), PTX3(3), RHO(7), RYR1(111)	36904482	342	217	337	96	60	118	80	25	57	2	0.0827	1.000	1.000
184	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(10), CD28(4), CD3D(2), CSK(2), CTLA4(3), DAG1(3), EPHB2(10), FBXW7(15), GRAP2(13), GRB2(6), ITK(16), ITPKA(2), ITPKB(7), LAT(4), LCK(9), LCP2(10), MAPK1(2), NCK1(5), NFAT5(13), NFKB1(6), NFKB2(5), NFKBIA(4), NFKBIB(3), NFKBIE(2), NFKBIL1(1), PAK1(9), PAK2(3), PAK3(16), PAK4(6), PAK6(2), PAK7(37), PLCG1(7), PTPRC(41), RAF1(6), RASGRP1(3), RASGRP2(7), RASGRP3(11), RASGRP4(9), SOS1(17), SOS2(13), VAV1(8), ZAP70(9)	44571429	361	215	351	113	50	141	66	25	79	0	0.493	1.000	1.000
185	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	92	ANK2(134), B3GALT4(1), CDR1(15), DGKI(35), IL6ST(3), MRPL19(1), PIGK(3), RPL10(4), RPL11(2), RPL13A(2), RPL14(2), RPL15(1), RPL17(2), RPL19(2), RPL21(1), RPL22(1), RPL24(1), RPL26(3), RPL27A(2), RPL28(2), RPL29(1), RPL3(3), RPL30(2), RPL31(1), RPL34(1), RPL37(2), RPL3L(8), RPL4(5), RPL41(1), RPL5(8), RPL6(4), RPL7(2), RPL8(3), RPL9(1), RPLP0(2), RPLP1(1), RPLP2(3), RPS10(3), RPS11(1), RPS13(1), RPS14(1), RPS15(2), RPS18(2), RPS19(1), RPS2(2), RPS20(1), RPS25(2), RPS26(1), RPS27(1), RPS28(1), RPS29(1), RPS3(5), RPS3A(2), RPS4X(2), RPS4Y1(1), RPS5(2), RPS6(3), RPS6KA1(6), RPS6KA2(8), RPS6KA3(6), RPS6KA6(18), RPS6KB1(3), RPS6KB2(3), RPS7(1), RPSA(1), SLC36A2(6), UBA52(1), UBC(14)	41571862	367	213	361	103	38	173	72	27	55	2	0.191	1.000	1.000
186	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	31	AKT1(3), AKT2(7), AKT3(7), BCR(11), BTK(25), CD19(5), DAPP1(3), FLOT1(1), FLOT2(4), GAB1(7), ITPR1(20), ITPR2(40), ITPR3(21), LYN(6), NR0B2(3), PDK1(6), PITX2(8), PLCG2(18), PPP1R13B(7), PREX1(40), PTEN(11), PTPRC(41), RPS6KA1(6), RPS6KA2(8), RPS6KA3(6), RPS6KB1(3), SAG(5), SYK(5), TEC(12), VAV1(8)	42148032	347	212	345	86	46	128	77	21	75	0	0.0123	1.000	1.000
187	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(5), F11(13), F12(4), F13B(28), F2(9), F5(40), F7(10), F8(56), F9(20), FGA(20), FGB(18), FGG(4), LPA(47), PLAT(12), PLG(32), SERPINB2(14), SERPINE1(14), SERPINF2(2), VWF(32)	28374054	380	210	374	103	24	171	80	38	66	1	0.179	1.000	1.000
188	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AADAT(3), AANAT(1), ACAT1(2), ACAT2(2), ACMSD(2), AFMID(4), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH7A1(3), ALDH9A1(3), AOC2(6), AOC3(11), AOX1(22), ASMT(13), CARM1(4), CAT(3), CYP1A1(9), CYP1A2(3), CYP1B1(5), DDC(8), ECHS1(4), EHHADH(13), GCDH(7), HAAO(1), HADH(2), HADHA(3), HSD17B10(2), HSD17B4(8), INMT(8), KMO(9), KYNU(17), LCMT1(5), LCMT2(7), LNX1(9), MAOA(5), MAOB(3), METTL2B(5), METTL6(1), NFX1(5), OGDH(10), OGDHL(35), PRMT2(2), PRMT3(8), PRMT5(7), PRMT6(7), PRMT7(4), PRMT8(13), TDO2(9), TPH1(8), TPH2(16), WARS(6), WARS2(7), WBSCR22(3)	48745420	383	210	376	110	53	128	82	50	70	0	0.160	1.000	1.000
189	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(3), AASDHPPT(4), AASS(20), ACAT1(2), ACAT2(2), AKR1B10(10), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH7A1(3), ALDH9A1(3), BBOX1(11), DLST(5), DOT1L(14), ECHS1(4), EHHADH(13), EHMT1(15), EHMT2(9), GCDH(7), HADH(2), HADHA(3), HSD17B10(2), HSD17B4(8), HSD3B7(7), NSD1(23), OGDH(10), OGDHL(35), PIPOX(2), PLOD1(5), PLOD2(12), PLOD3(10), RDH11(4), RDH12(3), RDH13(1), RDH14(2), SETD1A(18), SETD7(2), SETDB1(11), SHMT1(2), SHMT2(2), SPCS1(1), SPCS3(2), SUV39H1(1), SUV39H2(4), TMLHE(9)	46424015	336	209	332	93	50	131	73	33	47	2	0.0900	1.000	1.000
190	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	44	ADH1A(8), ADH1B(12), ADH4(4), ADH6(8), ADH7(11), ADHFE1(5), AGPAT1(9), AGPAT2(3), AGPAT3(4), AGPAT4(9), AKR1A1(1), AKR1B1(7), ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH9A1(3), CEL(8), DGAT1(1), DGKA(7), DGKB(40), DGKD(10), DGKE(5), DGKG(15), DGKH(14), DGKQ(1), DGKZ(5), GK(7), GLA(9), GLB1(3), LCT(50), LIPC(9), LIPF(8), LIPG(11), LPL(8), PNLIPRP1(14), PPAP2A(2), PPAP2B(3), PPAP2C(1)	37689476	361	207	355	90	46	148	74	30	63	0	0.00844	1.000	1.000
191	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	63	ACHE(4), AGPAT1(9), AGPAT2(3), AGPAT3(4), AGPAT4(9), AGPAT6(5), CDIPT(1), CDS1(3), CDS2(4), CHAT(22), CHKA(4), CHKB(4), CHPT1(3), DGKA(7), DGKB(40), DGKD(10), DGKE(5), DGKG(15), DGKH(14), DGKI(35), DGKQ(1), DGKZ(5), ESCO1(10), ESCO2(4), ETNK1(5), GNPAT(5), GPAM(6), GPD1(3), GPD1L(4), GPD2(9), LCAT(6), NAT6(1), PCYT1A(2), PCYT1B(3), PEMT(2), PISD(2), PLA2G12A(4), PLA2G12B(3), PLA2G1B(2), PLA2G2A(5), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(6), PLA2G4A(21), PLA2G6(3), PLD1(19), PLD2(7), PNPLA3(4), PPAP2A(2), PPAP2B(3), PPAP2C(1), PTDSS1(10), PTDSS2(3)	52161680	368	207	361	118	42	131	92	34	67	2	0.721	1.000	1.000
192	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	22	IMPA1(1), INPP1(8), INPP4A(7), INPP4B(27), INPP5A(3), INPPL1(11), ITPKA(2), ITPKB(7), MIOX(2), OCRL(13), PIK3C2A(12), PIK3C2B(22), PIK3C2G(19), PIK3CB(8), PIK3CG(33), PLCB1(52), PLCB2(12), PLCB3(9), PLCB4(35), PLCD1(4), PLCG1(7), PLCG2(18)	34137258	312	202	309	85	44	118	67	27	55	1	0.108	1.000	1.000
193	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	51	ACTG1(6), APAF1(10), ARHGDIB(2), BCL2(5), BID(2), BIRC2(2), BIRC3(4), CASP2(13), CASP3(5), CASP6(3), CASP7(3), CASP8(6), CASP9(6), CFLAR(2), CHUK(7), CRADD(3), CYCS(2), DAXX(8), DFFA(3), DFFB(4), FADD(2), GSN(4), LMNA(2), LMNB1(5), LMNB2(5), MAP2K7(7), MAP3K1(7), MAP3K5(14), MAPK8(2), MDM2(5), NFKB1(6), NFKBIA(4), NUMA1(16), PAK2(3), PRKCD(7), PRKDC(50), PSEN1(6), PSEN2(9), PTK2(6), RASA1(11), RELA(3), RIPK1(11), SPTAN1(21), TNF(2), TNFRSF1B(2), TRADD(2), TRAF1(2), TRAF2(5)	53904554	315	201	314	91	27	101	73	40	74	0	0.558	1.000	1.000
194	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(9), ALPL(3), ALPP(13), ALPPL2(4), ASCC3(23), ATP13A2(11), DDX18(9), DDX23(5), DDX4(10), DDX41(3), DDX47(1), DDX50(12), DDX52(4), DDX54(7), DDX55(3), DDX56(3), DHFR(2), DHX58(4), ENTPD7(6), EP400(32), ERCC2(5), ERCC3(5), FPGS(3), GCH1(3), GGH(9), IFIH1(10), MOV10L1(11), NUDT5(2), NUDT8(2), PTS(1), QDPR(7), RAD54B(8), RAD54L(7), RUVBL2(4), SETX(27), SKIV2L2(15), SMARCA2(22), SMARCA5(5), SPR(3)	50269127	313	199	311	95	33	102	82	35	61	0	0.533	1.000	1.000
195	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	34	ACTA1(9), CRK(1), CRKL(4), DOCK1(15), ELK1(3), FOS(3), GAB1(7), GRB2(6), HGF(54), HRAS(2), ITGA1(14), ITGB1(6), JUN(3), MAP2K1(10), MAP2K2(1), MAP4K1(12), MAPK1(2), MAPK3(3), MAPK8(2), MET(22), PAK1(9), PIK3R1(4), PTEN(11), PTK2(6), PTK2B(14), PTPN11(9), PXN(1), RAF1(6), RAP1A(1), RAP1B(2), RASA1(11), SOS1(17), SRC(2), STAT3(11)	33712135	283	198	272	91	23	97	59	40	64	0	0.859	1.000	1.000
196	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP2(1), ADH1A(8), ADH1B(12), ADH4(4), ADH6(8), ADH7(11), ADHFE1(5), AKR1A1(1), ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH3B1(2), ALDH3B2(4), ALDH9A1(3), ALDOA(4), ALDOB(8), ALDOC(2), BPGM(6), DLAT(10), DLD(9), ENO1(7), ENO2(2), ENO3(3), FBP1(2), FBP2(2), G6PC(7), GAPDH(5), GCK(6), GPI(8), HK1(12), HK2(11), HK3(22), LDHA(10), LDHB(4), LDHC(6), PDHA1(5), PDHA2(29), PFKM(7), PFKP(5), PGAM1(1), PGK1(4), PGM1(3), PGM3(3), PKLR(16), TPI1(9)	39312877	333	197	329	91	48	135	63	30	57	0	0.0416	1.000	1.000
197	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP2(1), ADH1A(8), ADH1B(12), ADH4(4), ADH6(8), ADH7(11), ADHFE1(5), AKR1A1(1), ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH3B1(2), ALDH3B2(4), ALDH9A1(3), ALDOA(4), ALDOB(8), ALDOC(2), BPGM(6), DLAT(10), DLD(9), ENO1(7), ENO2(2), ENO3(3), FBP1(2), FBP2(2), G6PC(7), GAPDH(5), GCK(6), GPI(8), HK1(12), HK2(11), HK3(22), LDHA(10), LDHB(4), LDHC(6), PDHA1(5), PDHA2(29), PFKM(7), PFKP(5), PGAM1(1), PGK1(4), PGM1(3), PGM3(3), PKLR(16), TPI1(9)	39312877	333	197	329	91	48	135	63	30	57	0	0.0416	1.000	1.000
198	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	31	ADRA1A(7), ADRA1B(8), ADRA1D(8), ADRA2A(3), ADRA2C(3), ADRB1(1), ADRB2(4), ADRB3(6), CHRM1(5), CHRM2(39), CHRM3(27), CHRM4(8), CHRM5(6), DRD1(13), DRD3(19), DRD4(2), DRD5(26), HRH1(5), HRH2(17), HTR1A(24), HTR1B(7), HTR1D(5), HTR1E(23), HTR1F(10), HTR2A(6), HTR2B(5), HTR2C(8), HTR4(6), HTR5A(21), HTR6(10), HTR7(11)	19764090	343	197	338	123	51	158	65	26	42	1	0.116	1.000	1.000
199	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(12), ALDH4A1(6), ALDH5A1(2), CAD(25), CPS1(71), EARS2(5), EPRS(27), GAD1(7), GAD2(27), GCLC(13), GFPT1(8), GFPT2(10), GLS(8), GLS2(6), GLUD1(4), GLUD2(15), GLUL(6), GMPS(9), GNPNAT1(1), GOT1(3), GOT2(6), GPT2(5), GSR(5), GSS(4), NADSYN1(2), NAGK(6), PPAT(1), QARS(6)	31784864	300	193	299	75	27	122	53	35	62	1	0.0507	1.000	1.000
200	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	CAD(25), CANT1(3), CDA(2), CTPS2(6), DCK(2), DCTD(4), DHODH(1), DPYD(24), DPYS(22), ENTPD1(7), ITPA(1), NT5E(5), NT5M(3), NUDT2(3), POLB(4), POLD1(7), POLD2(3), POLE(31), POLG(12), POLL(7), POLQ(36), POLR1B(11), POLR2A(11), POLR2B(10), POLR2C(4), POLR2D(3), POLR2E(2), POLR2F(1), POLR2G(1), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(2), POLRMT(8), RRM1(6), RRM2(6), TK1(1), TK2(1), TXNRD1(7), TYMS(3), UCK2(10), UMPS(4), UNG(5), UPB1(2), UPP1(6)	45844839	316	193	314	95	39	126	70	31	48	2	0.394	1.000	1.000
201	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ADH1A(8), ADH1B(12), ADH4(4), ADH5(2), ADH6(8), ADH7(11), ADHFE1(5), ALDH1A3(4), ALDH3A1(5), ALDH3B1(2), ALDH3B2(4), AOC2(6), AOC3(11), AOX1(22), CARM1(4), COMT(1), DBH(12), DCT(16), DDC(8), ECH1(1), ESCO1(10), ESCO2(4), FAH(2), GOT1(3), GOT2(6), GSTZ1(2), HGD(5), HPD(2), LCMT1(5), LCMT2(7), MAOA(5), MAOB(3), METTL2B(5), METTL6(1), NAT6(1), PNMT(1), PNPLA3(4), PRMT2(2), PRMT3(8), PRMT5(7), PRMT6(7), PRMT7(4), PRMT8(13), TAT(9), TH(7), TPO(33), TYR(29), TYRP1(5), WBSCR22(3)	47774422	339	192	334	110	56	123	57	38	65	0	0.435	1.000	1.000
202	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	41	AKT1(3), AKT2(7), AKT3(7), CAB39(2), DDIT4(4), EIF4B(7), FIGF(4), HIF1A(2), IGF1(4), MAPK1(2), MAPK3(3), PDPK1(3), PGF(1), PIK3CB(8), PIK3CD(4), PIK3CG(33), PIK3R1(4), PIK3R2(7), PIK3R3(5), PIK3R5(17), PRKAA1(6), PRKAA2(8), RHEB(4), RICTOR(25), RPS6(3), RPS6KA1(6), RPS6KA2(8), RPS6KA3(6), RPS6KA6(18), RPS6KB1(3), RPS6KB2(3), TSC1(10), TSC2(13), ULK1(8), ULK2(9), ULK3(2), VEGFA(1), VEGFB(2), VEGFC(21)	38591681	283	192	280	83	41	114	58	30	39	1	0.269	1.000	1.000
203	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	40	ALAD(1), ALAS1(2), ALAS2(6), BLVRA(3), BLVRB(2), COX10(4), CP(11), CPOX(4), EARS2(5), EPRS(27), FECH(4), FTH1(2), FTMT(11), GUSB(5), HCCS(3), HMBS(5), HMOX1(3), MMAB(3), PPOX(7), UGT1A1(12), UGT1A10(9), UGT1A3(6), UGT1A4(4), UGT1A5(8), UGT1A6(9), UGT1A7(7), UGT1A9(7), UGT2A1(16), UGT2A3(11), UGT2B10(9), UGT2B11(23), UGT2B15(14), UGT2B17(12), UGT2B4(28), UGT2B7(14), UROS(2)	33340378	299	191	297	92	21	140	71	23	44	0	0.536	1.000	1.000
204	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	AGMAT(2), ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH4A1(6), ALDH9A1(3), AMD1(2), AOC2(6), AOC3(11), ARG1(2), ASL(4), CKB(1), CKM(4), CKMT1A(1), CKMT1B(1), CKMT2(2), CPS1(71), DAO(7), GATM(8), GLUD1(4), GOT1(3), GOT2(6), MAOA(5), MAOB(3), NOS1(29), NOS3(12), OAT(3), ODC1(1), OTC(10), P4HA1(5), P4HA2(5), P4HA3(4), P4HB(5), PYCR1(1), RARS(6), SMS(3)	35307606	282	190	280	90	37	101	55	38	50	1	0.391	1.000	1.000
205	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(7), AKR1B10(10), B4GALT1(1), B4GALT2(4), G6PC(7), G6PC2(8), GAA(12), GALK1(3), GALK2(3), GALT(5), GANC(3), GCK(6), GLA(9), GLB1(3), HK1(12), HK2(11), HK3(22), HSD3B7(7), LCT(50), MGAM(51), PFKL(9), PFKM(7), PFKP(5), PGM1(3), PGM3(3), RDH11(4), RDH12(3), RDH13(1), RDH14(2), UGP2(4)	30815039	275	190	274	82	46	115	57	20	37	0	0.131	1.000	1.000
206	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	AANAT(1), ACAT1(2), ACAT2(2), ACMSD(2), ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH9A1(3), AOC2(6), AOC3(11), AOX1(22), ASMT(13), CAT(3), CYP19A1(4), CYP1A1(9), CYP1A2(3), CYP2A13(13), CYP2A6(6), CYP2A7(7), CYP2B6(10), CYP2C18(7), CYP2C19(13), CYP2C8(2), CYP2C9(8), CYP2D6(1), CYP2E1(7), CYP2F1(3), CYP2J2(1), CYP3A4(4), CYP3A5(5), CYP3A7(7), CYP4B1(14), CYP51A1(5), DDC(8), ECHS1(4), EHHADH(13), GCDH(7), HAAO(1), HADHA(3), KMO(9), KYNU(17), MAOA(5), MAOB(3), SDS(4), TDO2(9), TPH1(8), WARS(6), WARS2(7)	44374676	344	190	340	115	43	127	70	44	60	0	0.628	1.000	1.000
207	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOA(4), ALDOB(8), ALDOC(2), DLAT(10), DLD(9), ENO1(7), ENO2(2), ENO3(3), FBP1(2), FBP2(2), G6PC(7), GAPDH(5), GAPDHS(10), GCK(6), GOT1(3), GOT2(6), GPI(8), HK1(12), HK2(11), HK3(22), LDHA(10), LDHAL6B(3), LDHB(4), LDHC(6), MDH1(3), MDH2(3), PC(9), PCK1(21), PDHA1(5), PDHA2(29), PDHX(4), PFKL(9), PFKM(7), PFKP(5), PGAM1(1), PGAM2(1), PGK1(4), PGK2(27), PKLR(16), TNFAIP1(1), TPI1(9)	34015838	316	189	315	95	52	131	50	34	49	0	0.115	1.000	1.000
208	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	19	ADCYAP1R1(17), CALCR(27), CALCRL(18), CD97(12), CRHR1(7), EMR1(24), EMR2(13), GHRHR(5), GIPR(3), GLP1R(11), GLP2R(17), GPR64(14), LPHN1(7), LPHN2(47), LPHN3(78), SCTR(5), VIPR1(2), VIPR2(3)	20181072	310	188	307	97	34	129	57	36	53	1	0.264	1.000	1.000
209	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	37	AKT1(3), ATF2(10), CDC42(1), DLD(9), DUSP10(11), DUSP4(2), DUSP8(2), GAB1(7), GADD45A(2), GCK(6), IL1R1(2), JUN(3), MAP2K4(8), MAP2K5(4), MAP2K7(7), MAP3K1(7), MAP3K10(4), MAP3K11(5), MAP3K12(10), MAP3K13(12), MAP3K2(6), MAP3K3(10), MAP3K4(21), MAP3K5(14), MAP3K7(10), MAP3K9(17), MAPK10(6), MAPK7(7), MAPK8(2), MAPK9(8), MYEF2(12), NFATC3(15), NR2C2(2), PAPPA(32), SHC1(6), TRAF6(6), ZAK(7)	39690272	296	188	294	74	44	116	51	27	58	0	0.0784	1.000	1.000
210	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(7), ADRBK2(7), ARRB2(4), CALM1(3), CALM2(1), CALML3(3), CALML6(1), CAMK2A(3), CAMK2B(16), CAMK2D(7), CLCA1(14), CLCA2(29), CLCA4(30), CNGA3(15), CNGA4(15), CNGB1(10), GNAL(5), GUCA1A(7), GUCA1B(4), GUCA1C(7), PDC(1), PDE1C(28), PRKACA(3), PRKACB(9), PRKACG(4), PRKG1(20), PRKG2(15), PRKX(3)	24535411	271	187	270	86	28	118	53	22	50	0	0.440	1.000	1.000
211	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	65	APAF1(10), BAK1(3), BAX(3), BCL2(5), BCL2L1(3), BCL2L11(4), BID(2), BIRC2(2), BIRC3(4), BIRC5(3), BNIP3L(1), CASP1(8), CASP10(7), CASP2(13), CASP3(5), CASP4(6), CASP6(3), CASP7(3), CASP8(6), CASP9(6), CHUK(7), CYCS(2), DFFA(3), DFFB(4), FADD(2), FAS(4), FASLG(10), GZMB(6), HELLS(4), IKBKB(9), IRF1(1), IRF2(3), IRF4(12), IRF5(1), IRF6(12), IRF7(3), JUN(3), LTA(3), MAP2K4(8), MAP3K1(7), MAPK10(6), MDM2(5), MYC(4), NFKB1(6), NFKBIA(4), NFKBIB(3), NFKBIE(2), PLEKHG5(10), PRF1(8), RELA(3), RIPK1(11), TNF(2), TNFRSF10B(3), TNFRSF1B(2), TNFRSF21(3), TNFRSF25(2), TNFSF10(3), TP73(7), TRADD(2), TRAF1(2), TRAF2(5), TRAF3(4)	45200856	298	186	299	86	27	116	61	31	63	0	0.328	1.000	1.000
212	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(4), AGPAT1(9), AGPAT2(3), AGPAT3(4), AGPAT4(9), AGPS(6), CDIPT(1), CDS1(3), CDS2(4), CHAT(22), CHKA(4), CHKB(4), CLC(3), CPT1B(6), DGKA(7), DGKB(40), DGKD(10), DGKE(5), DGKG(15), DGKH(14), DGKQ(1), DGKZ(5), ETNK1(5), GNPAT(5), GPD1(3), GPD2(9), LCAT(6), LGALS13(5), PAFAH1B1(1), PAFAH2(3), PCYT1A(2), PCYT1B(3), PEMT(2), PISD(2), PLA2G1B(2), PLA2G2A(5), PLA2G2E(2), PLA2G3(6), PLA2G4A(21), PLA2G6(3), PLCB2(12), PLCG1(7), PLCG2(18), PPAP2A(2), PPAP2B(3), PPAP2C(1)	39734673	307	186	301	99	45	100	77	26	58	1	0.552	1.000	1.000
213	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(23), GABBR1(8), GPRC5A(3), GPRC5B(14), GPRC5C(10), GPRC5D(2), GRM1(48), GRM2(7), GRM3(19), GRM4(21), GRM5(40), GRM7(43), GRM8(52)	16886110	290	183	287	86	49	128	67	17	28	1	0.0406	1.000	1.000
214	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA2(2), ACADL(4), ACADM(8), ACADS(1), ACADSB(2), ACADVL(2), ACAT1(2), ACAT2(2), ACOX1(5), ACOX3(8), ACSL1(12), ACSL3(4), ACSL4(7), ACSL5(3), ACSL6(15), ADH1A(8), ADH1B(12), ADH4(4), ADH5(2), ADH6(8), ADH7(11), ADHFE1(5), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH7A1(3), ALDH9A1(3), CPT1A(11), CPT1B(6), CPT1C(13), CPT2(3), CYP4A11(8), CYP4A22(1), ECHS1(4), EHHADH(13), GCDH(7), HADH(2), HADHA(3), HADHB(10), HSD17B10(2), HSD17B4(8)	39393905	254	183	248	66	35	88	49	32	50	0	0.0878	1.000	1.000
215	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	71	CALR(2), CANX(5), CD4(8), CD8A(4), CD8B(5), CIITA(5), CREB1(2), CTSB(2), CTSS(3), HLA-A(8), HLA-B(4), HLA-C(5), HLA-DMA(4), HLA-DMB(3), HLA-DOA(2), HLA-DPA1(1), HLA-DQA2(3), HLA-DQB1(4), HLA-DRA(3), HLA-DRB1(5), HLA-E(2), HLA-G(5), HSP90AA1(8), HSP90AB1(9), HSPA5(3), IFNA1(2), IFNA10(7), IFNA14(4), IFNA16(8), IFNA17(5), IFNA2(5), IFNA21(3), IFNA4(4), IFNA5(5), IFNA7(6), IFNA8(7), KIR2DL3(8), KIR3DL1(17), KIR3DL2(5), KIR3DL3(2), KLRC1(5), KLRC2(2), KLRC3(5), KLRC4(2), KLRD1(2), LGMN(4), LTA(3), NFYA(1), NFYB(1), NFYC(6), PDIA3(4), PSME1(2), PSME2(3), RFX5(9), RFXANK(1), TAP1(1), TAP2(8), TAPBP(4)	36952896	256	183	249	82	22	104	58	28	44	0	0.645	1.000	1.000
216	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	31	AKT1(3), APC(33), AR(10), ASAH1(3), CAMP(4), CCL13(3), CCL15(5), CCL16(4), DAG1(3), GNA11(4), GNA15(1), GNAI1(10), GNAQ(5), ITPKA(2), ITPKB(7), ITPR1(20), ITPR2(40), ITPR3(21), KCNJ3(36), KCNJ5(10), KCNJ9(2), MAPK1(2), MAPK10(6), MAPK14(4), PHKA2(14), PIK3CD(4), PIK3R1(4), PITX2(8), PTX3(3), RAF1(6), SRC(2)	37709961	279	183	272	75	34	101	67	17	60	0	0.174	1.000	1.000
217	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(38), AR(10), ESR1(12), ESR2(6), HNF4A(21), NPM1(5), NR0B1(14), NR1D1(2), NR1D2(1), NR1H2(5), NR1H3(4), NR1I2(4), NR1I3(9), NR2C2(2), NR2E1(9), NR2F1(7), NR2F2(1), NR2F6(1), NR3C1(8), NR4A1(5), NR4A2(18), NR5A1(6), NR5A2(14), PGR(15), PPARA(4), PPARD(6), PPARG(8), RARA(7), RARB(7), RARG(3), ROR1(13), RORA(9), RORC(1), RXRA(1), RXRB(3), RXRG(18), THRA(5), THRB(4), VDR(4)	33642017	310	182	309	108	45	126	66	20	52	1	0.662	1.000	1.000
218	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	48	ACOX1(5), APOA1(3), APOA2(1), CD36(4), CITED2(3), CPT1B(6), CREBBP(30), DUSP1(1), EHHADH(13), EP300(11), HSD17B4(8), JUN(3), LPL(8), MAPK1(2), MAPK3(3), ME1(3), MRPL11(1), MYC(4), NCOA1(18), NCOR1(23), NCOR2(30), NFKBIA(4), NR0B2(3), NR1H3(4), NR2F1(7), NRIP1(13), PDGFA(5), PIK3R1(4), PPARA(4), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PRKCA(10), PTGS2(12), RELA(3), RXRA(1), SP1(6), STAT5A(3), STAT5B(8), TNF(2)	47429760	293	182	290	91	48	103	59	30	52	1	0.389	1.000	1.000
219	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	46	AKT1(3), AKT2(7), AKT3(7), BRD4(7), CBL(10), CDC42(1), F2RL2(12), FLOT1(1), FLOT2(4), GRB2(6), GSK3A(1), GSK3B(4), IGFBP1(6), INPPL1(11), IRS1(20), IRS4(34), LNPEP(5), MAPK1(2), MAPK3(3), PARD3(15), PARD6A(1), PDK1(6), PIK3CD(4), PIK3R1(4), PTEN(11), PTPN1(3), RAF1(6), RPS6KA1(6), RPS6KA2(8), RPS6KA3(6), RPS6KB1(3), SERPINB6(3), SFN(1), SHC1(6), SLC2A4(4), SORBS1(12), SOS1(17), SOS2(13), YWHAB(1), YWHAE(1), YWHAG(3), YWHAH(1), YWHAQ(4), YWHAZ(2)	44911241	285	182	280	78	38	114	68	18	46	1	0.153	1.000	1.000
220	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(3), AKT2(7), AKT3(7), ARHGEF11(24), BCL2(5), CDC42(1), DLG4(7), GNA13(6), LPA(47), MAP2K4(8), MAP3K1(7), MAP3K5(14), MAPK8(2), NFKB1(6), NFKB2(5), NFKBIA(4), NFKBIB(3), NFKBIE(2), NFKBIL1(1), PDK1(6), PHKA2(14), PI3(1), PIK3CB(8), PLD1(19), PLD2(7), PLD3(4), PTK2(6), RDX(2), ROCK1(19), ROCK2(9), SERPINA4(16), SRF(1), TBXA2R(1)	39339807	272	182	268	72	25	115	50	32	50	0	0.170	1.000	1.000
221	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	21	ATM(53), ATR(26), BRCA1(22), CCNB1(2), CDC25A(4), CDC25B(1), CDC25C(8), CDC34(2), CDKN1A(2), CDKN2D(2), CHEK1(7), CHEK2(10), EP300(11), GADD45A(2), MDM2(5), MYT1(24), PRKDC(50), RPS6KA1(6), WEE1(4), YWHAH(1), YWHAQ(4)	32988191	246	180	244	39	19	75	50	36	64	2	0.000718	1.000	1.000
222	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(14), AADAC(5), ABAT(12), ACADS(1), ACAT1(2), ACAT2(2), ACSM1(10), AKR1B10(10), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH5A1(2), ALDH7A1(3), ALDH9A1(3), BDH1(4), BDH2(2), DDHD1(11), ECHS1(4), EHHADH(13), GAD1(7), GAD2(27), HADH(2), HADHA(3), HMGCL(1), HMGCS1(11), HMGCS2(7), HSD17B10(2), HSD17B4(8), HSD3B7(7), ILVBL(3), L2HGDH(6), OXCT1(7), OXCT2(2), PDHA1(5), PDHA2(29), PLA1A(6), PPME1(6), PRDX6(5), RDH11(4), RDH12(3), RDH13(1), RDH14(2)	32639019	282	180	280	88	32	105	64	26	53	2	0.489	1.000	1.000
223	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(20), ACACB(28), ACAT1(2), ACAT2(2), ACOT12(11), ACSS1(5), ACSS2(4), ACYP2(1), AKR1B1(7), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH7A1(3), ALDH9A1(3), DLAT(10), DLD(9), GLO1(1), GRHPR(4), HAGH(4), HAGHL(3), LDHA(10), LDHAL6A(1), LDHAL6B(3), LDHB(4), LDHC(6), LDHD(2), MDH1(3), MDH2(3), ME1(3), ME2(9), ME3(8), PC(9), PCK1(21), PCK2(4), PDHA1(5), PDHA2(29), PKLR(16)	37616402	283	179	282	93	43	109	49	30	52	0	0.563	1.000	1.000
224	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	36	CALM1(3), CALM2(1), CAMK1(1), CAMK1G(2), ELK1(3), FPR1(10), GNA15(1), GNB1(2), GNGT1(6), HRAS(2), MAP2K1(10), MAP2K2(1), MAP2K3(13), MAP2K6(5), MAP3K1(7), MAPK1(2), MAPK14(4), MAPK3(3), NCF1(3), NCF2(8), NFATC1(9), NFATC2(15), NFATC3(15), NFATC4(11), NFKB1(6), NFKBIA(4), PAK1(9), PIK3C2G(19), PLCB1(52), PPP3CB(3), PPP3CC(3), RAF1(6), RELA(3), SYT1(6)	29794818	248	177	241	67	29	108	44	18	49	0	0.109	1.000	1.000
225	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	112	ATP12A(13), ATP4A(16), ATP5A1(4), ATP5B(3), ATP5C1(4), ATP5E(1), ATP5F1(3), ATP5G3(2), ATP5J2(3), ATP5L(3), ATP5O(1), ATP6AP1(3), ATP6V0A1(6), ATP6V0A2(4), ATP6V0A4(8), ATP6V0B(2), ATP6V0C(4), ATP6V0D1(2), ATP6V0D2(8), ATP6V1A(6), ATP6V1B1(3), ATP6V1B2(5), ATP6V1C1(7), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1E2(5), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3), COX10(4), COX4I1(3), COX5A(1), COX5B(2), COX6B1(2), COX6B2(1), COX6C(1), COX7B2(3), COX8A(1), COX8C(2), CYC1(7), LHPP(3), NDUFA1(2), NDUFA10(5), NDUFA11(1), NDUFA12(5), NDUFA13(1), NDUFA4(2), NDUFA5(2), NDUFA6(1), NDUFA7(1), NDUFA8(5), NDUFA9(4), NDUFB1(1), NDUFB10(3), NDUFB11(6), NDUFB2(2), NDUFB4(1), NDUFB5(6), NDUFB6(2), NDUFB8(1), NDUFB9(2), NDUFC2(3), NDUFS1(10), NDUFS2(4), NDUFS3(3), NDUFS4(3), NDUFS5(1), NDUFS6(2), NDUFS7(1), NDUFS8(2), NDUFV1(2), NDUFV2(1), NDUFV3(1), PPA1(2), SDHA(8), SDHB(1), SDHD(3), TCIRG1(2), UQCRB(5), UQCRC1(2), UQCRC2(5), UQCRFS1(3), UQCRH(3), UQCRQ(2)	44713921	281	177	278	104	47	92	57	24	59	2	0.863	1.000	1.000
226	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(6), ARG1(2), ASL(4), ASS1(5), CKB(1), CKM(4), CKMT1A(1), CKMT1B(1), CKMT2(2), CPS1(71), DAO(7), EPRS(27), GATM(8), GLUD1(4), GLUD2(15), GOT1(3), GOT2(6), LAP3(4), NOS1(29), NOS3(12), OAT(3), OTC(10), P4HA1(5), P4HA2(5), P4HA3(4), PARS2(1), PRODH(4), PYCR1(1), PYCR2(6), PYCRL(1), RARS(6), RARS2(6)	28625139	264	177	261	73	29	111	51	29	43	1	0.114	1.000	1.000
227	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(5), ALOX12(8), ALOX12B(7), ALOX15(5), ALOX15B(6), ALOX5(10), CYP2B6(10), CYP2C18(7), CYP2C19(13), CYP2C8(2), CYP2C9(8), CYP2E1(7), CYP2J2(1), CYP2U1(2), CYP4A11(8), CYP4A22(1), CYP4F2(15), CYP4F3(16), DHRS4(1), EPHX2(3), GGT1(1), GPX3(2), GPX5(7), GPX6(7), GPX7(4), LTA4H(3), PLA2G12A(4), PLA2G12B(3), PLA2G1B(2), PLA2G2A(5), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(6), PLA2G4A(21), PLA2G6(3), PTGDS(4), PTGIS(12), PTGS1(18), PTGS2(12), TBXAS1(11)	31159882	266	177	263	76	38	104	60	25	39	0	0.121	1.000	1.000
228	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	41	BCL2(5), CHUK(7), DAXX(8), EGF(13), ETS1(8), ETS2(6), FOS(3), HOXA7(6), HRAS(2), IKBKB(9), JUN(3), MAP2K1(10), MAP2K3(13), MAP2K4(8), MAP2K6(5), MAP2K7(7), MAP3K1(7), MAP3K5(14), MAPK1(2), MAPK13(1), MAPK14(4), MAPK3(3), MAPK8(2), NFKB1(6), NFKBIA(4), PPP2CA(1), PRKCA(10), PRKCD(7), PRKCE(5), PRKCG(20), PRKCH(6), PRKCQ(12), RAF1(6), RELA(3), RIPK1(11), SP1(6), TNF(2), TNFRSF1B(2), TRAF2(5)	37301556	252	177	248	91	29	85	53	29	54	2	0.904	1.000	1.000
229	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	40	CALM1(3), CALM2(1), CD3D(2), CD3E(2), ELK1(3), FOS(3), FYN(8), GRB2(6), HRAS(2), JUN(3), LAT(4), LCK(9), MAP2K1(10), MAP2K4(8), MAP3K1(7), MAPK3(3), MAPK8(2), NFATC1(9), NFATC2(15), NFATC3(15), NFATC4(11), NFKB1(6), NFKBIA(4), PIK3R1(4), PLCG1(7), PPP3CB(3), PPP3CC(3), PRKCA(10), PTPN7(1), RAF1(6), RASA1(11), RELA(3), SHC1(6), SOS1(17), SYT1(6), VAV1(8), ZAP70(9)	35847130	230	177	225	76	37	82	40	20	51	0	0.625	1.000	1.000
230	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(12), ALDH4A1(6), ALDH5A1(2), CAD(25), CPS1(71), EPRS(27), GAD1(7), GAD2(27), GCLC(13), GFPT1(8), GLS(8), GLS2(6), GLUD1(4), GLUL(6), GMPS(9), GOT1(3), GOT2(6), GPT2(5), GSS(4), NADSYN1(2), PPAT(1), QARS(6)	26707796	258	176	257	66	23	103	44	31	56	1	0.115	1.000	1.000
231	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	38	AKT1(3), AKT2(7), AKT3(7), BCR(11), BLNK(2), BTK(25), CD19(5), CSK(2), DAG1(3), EPHB2(10), GRB2(6), ITPKA(2), ITPKB(7), LYN(6), MAP2K1(10), MAP2K2(1), MAPK1(2), NFAT5(13), NFKB1(6), NFKB2(5), NFKBIA(4), NFKBIB(3), NFKBIE(2), NFKBIL1(1), PI3(1), PIK3CD(4), PIK3R1(4), PLCG2(18), PPP1R13B(7), RAF1(6), SERPINA4(16), SHC1(6), SOS1(17), SOS2(13), SYK(5), VAV1(8)	40273382	248	176	240	81	29	84	63	24	48	0	0.630	1.000	1.000
232	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CD14(1), CHUK(7), ELK1(3), FOS(3), IKBKB(9), IRAK1(6), JUN(3), LY96(3), MAP2K3(13), MAP2K4(8), MAP2K6(5), MAP3K1(7), MAP3K7(10), MAPK14(4), MAPK8(2), MYD88(1), NFKB1(6), NFKBIA(4), PPARA(4), RELA(3), TLR10(16), TLR2(10), TLR3(4), TLR4(64), TLR6(11), TLR7(17), TLR9(9), TOLLIP(2), TRAF6(6)	29367557	241	176	240	80	15	100	47	26	53	0	0.752	1.000	1.000
233	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	24	ATM(53), BMPR1B(7), CCND2(4), CDK4(3), CDKN1B(5), DAZL(2), DMC1(1), EGR1(6), ESR2(6), FSHR(37), GJA4(6), INHA(1), LHCGR(14), MLH1(8), MSH5(8), NCOR1(23), NR5A1(6), NRIP1(13), PGR(15), PRLR(18), PTGER2(4), SMPD1(3), VDR(4), ZP2(5)	28059230	252	175	247	55	36	92	51	28	43	2	0.0177	1.000	1.000
234	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(4), AKR1D1(12), ARSB(6), ARSD(6), ARSE(5), CYP11B1(27), CYP11B2(24), HSD11B1(9), HSD17B2(6), HSD17B3(3), HSD3B1(6), HSD3B2(15), SRD5A1(4), STS(9), SULT1E1(11), SULT2A1(6), UGT1A1(12), UGT1A10(9), UGT1A3(6), UGT1A4(4), UGT1A5(8), UGT1A6(9), UGT1A7(7), UGT1A9(7), UGT2B15(14), UGT2B4(28)	22158661	257	174	254	75	21	117	64	24	30	1	0.196	1.000	1.000
235	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(4), AGTR2(6), CALM1(3), CALM2(1), CAMK2A(3), CAMK2B(16), CAMK2D(7), CDK5(3), F2(9), FYN(8), GNA11(4), GNAI1(10), GNB1(2), GNGT1(6), GRB2(6), HRAS(2), JAK2(16), MAP2K1(10), MAP2K2(1), MAPK1(2), MAPK14(4), MAPK3(3), MAPK8(2), MAPT(15), MYLK(26), PLCG1(7), PRKCA(10), PTK2B(14), RAF1(6), SHC1(6), SOS1(17), STAT1(7), STAT3(11), STAT5A(3), SYT1(6)	33357943	256	174	251	77	45	87	46	28	50	0	0.295	1.000	1.000
236	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(7), B4GALT1(1), B4GALT2(4), FBP2(2), G6PC(7), GAA(12), GALK1(3), GALK2(3), GALT(5), GANAB(9), GCK(6), GLA(9), GLB1(3), HK1(12), HK2(11), HK3(22), LCT(50), MGAM(51), PFKM(7), PFKP(5), PGM1(3), PGM3(3)	26076697	235	174	234	67	37	102	48	16	32	0	0.0743	1.000	1.000
237	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B3GNT6(5), B4GALT5(6), C1GALT1(5), C1GALT1C1(4), GALNT1(6), GALNT10(6), GALNT11(3), GALNT12(3), GALNT13(35), GALNT14(24), GALNT2(11), GALNT3(12), GALNT4(4), GALNT5(10), GALNT6(5), GALNT7(9), GALNT8(19), GALNTL5(5), GCNT1(8), GCNT3(2), GCNT4(9), OGT(19), ST3GAL1(4), ST3GAL2(4), ST6GALNAC1(8), WBSCR17(33)	26072743	259	174	255	98	35	99	69	22	34	0	0.966	1.000	1.000
238	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	AGXT(8), AGXT2(13), AKR1B10(10), ALAS1(2), ALAS2(6), AMT(1), AOC2(6), AOC3(11), BHMT(7), CBS(1), CHDH(2), CHKA(4), CHKB(4), CTH(2), DAO(7), DLD(9), DMGDH(11), GARS(3), GATM(8), GCAT(7), GLDC(26), GNMT(1), HSD3B7(7), MAOA(5), MAOB(3), PEMT(2), PHGDH(7), PIPOX(2), PISD(2), PSAT1(5), PSPH(6), RDH11(4), RDH12(3), RDH13(1), RDH14(2), SARDH(10), SARS(5), SARS2(4), SDS(4), SHMT1(2), SHMT2(2), TARS(14), TARS2(11)	34156007	250	173	249	82	37	91	53	27	41	1	0.383	1.000	1.000
239	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(9), ACTN1(7), ACTN2(43), BCAR1(3), BCR(11), CAPN1(2), CAPNS1(1), CAPNS2(2), CAV1(1), CRKL(4), CSK(2), FYN(8), GRB2(6), HRAS(2), ITGA1(14), ITGB1(6), JUN(3), MAP2K1(10), MAP2K2(1), MAPK1(2), MAPK3(3), MAPK8(2), PPP1R12B(15), PTK2(6), PXN(1), RAF1(6), RAP1A(1), ROCK1(19), SHC1(6), SOS1(17), SRC(2), TLN1(15), VCL(8), ZYX(6)	37582153	244	171	238	85	34	84	53	32	41	0	0.761	1.000	1.000
240	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	40	AKT1(3), ASAH1(3), ATF1(1), CAMP(4), CREB1(2), CREB5(18), CREBBP(30), CRKL(4), DAG1(3), EGR1(6), EGR2(4), EGR3(1), EGR4(3), ELK1(3), FRS2(10), GNAQ(5), JUN(3), MAP1B(29), MAP2K4(8), MAP2K7(7), MAPK1(2), MAPK10(6), MAPK3(3), MAPK8(2), MAPK8IP1(4), MAPK8IP2(2), MAPK8IP3(7), MAPK9(8), NTRK1(14), OPN1LW(9), PIK3C2G(19), PIK3CD(4), PIK3R1(4), PTPN11(9), RPS6KA3(6), SHC1(6), SRC(2), TH(7)	37876993	261	171	258	80	48	101	52	16	43	1	0.173	1.000	1.000
241	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	31	ACVR1(7), APC(33), ATF2(10), AXIN1(7), BMP10(11), BMP2(1), BMP4(6), BMP5(6), BMP7(12), BMPR1A(4), BMPR2(10), CHRD(13), DVL1(5), FZD1(6), GATA4(7), GSK3B(4), MAP3K7(10), MEF2C(6), MYL2(8), NKX2-5(8), NOG(1), NPPA(3), NPPB(3), RFC1(13), TGFB1(3), TGFB2(10), TGFBR1(7), TGFBR2(7), TGFBR3(19), WNT1(6)	27853591	246	170	242	66	36	90	45	25	50	0	0.233	1.000	1.000
242	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(4), AARS2(9), CARS(4), CARS2(3), DARS(3), DARS2(4), EARS2(5), EPRS(27), FARS2(5), FARSA(5), FARSB(5), GARS(3), HARS(5), HARS2(4), IARS(9), IARS2(15), KARS(8), LARS(14), LARS2(2), MARS(5), MARS2(13), MTFMT(1), NARS(4), NARS2(6), PARS2(1), QARS(6), RARS(6), RARS2(6), SARS(5), SARS2(4), TARS(14), TARS2(11), VARS(10), VARS2(2), WARS(6), WARS2(7), YARS(3), YARS2(10)	43790134	254	170	251	63	27	95	56	24	52	0	0.0730	1.000	1.000
243	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	35	BTK(25), CALM1(3), CALM2(1), ELK1(3), FCER1A(9), FCER1G(2), FOS(3), GRB2(6), HRAS(2), JUN(3), LYN(6), MAP2K1(10), MAP2K4(8), MAP2K7(7), MAP3K1(7), MAPK1(2), MAPK3(3), MAPK8(2), NFATC1(9), NFATC2(15), NFATC3(15), NFATC4(11), PAK2(3), PIK3R1(4), PLA2G4A(21), PLCG1(7), PPP3CB(3), PPP3CC(3), RAF1(6), SHC1(6), SOS1(17), SYK(5), SYT1(6), VAV1(8)	31910439	241	169	236	65	31	87	56	18	49	0	0.156	1.000	1.000
244	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(2), ALG10(15), ALG10B(8), ALG11(7), ALG12(3), ALG13(15), ALG14(1), ALG2(3), ALG3(4), ALG5(1), ALG6(1), ALG8(3), ALG9(5), B4GALT1(1), B4GALT2(4), B4GALT3(2), DAD1(2), DDOST(1), DHDDS(2), DOLPP1(1), DPAGT1(5), DPM1(5), FUT8(7), GANAB(9), MAN1A1(3), MAN1A2(7), MAN1B1(4), MAN1C1(3), MAN2A1(20), MGAT1(7), MGAT2(5), MGAT3(15), MGAT4A(3), MGAT4B(7), MGAT5(13), MGAT5B(22), RFT1(4), RPN1(3), RPN2(4), ST6GAL1(4), STT3B(4)	33965732	235	169	235	63	28	96	43	28	40	0	0.159	1.000	1.000
245	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	20	CALM1(3), CALM2(1), DLG4(7), GRIN1(9), GRIN2A(61), GRIN2B(53), GRIN2C(8), GRIN2D(9), NOS1(29), PPP3CB(3), PPP3CC(3), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PRKCA(10), SYT1(6)	19540856	226	169	223	75	43	94	45	13	29	2	0.314	1.000	1.000
246	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	31	ACTR2(4), ACTR3(2), AKT1(3), ANGPTL2(5), DAG1(3), DGKA(7), GCA(3), ITGA9(6), ITPKA(2), ITPKB(7), ITPR1(20), ITPR2(40), ITPR3(21), MAP2K1(10), MAPK1(2), MAPK3(3), NR1I3(9), PAK1(9), PDE3A(30), PDE3B(16), PI3(1), PIK3C2G(19), PIK3CD(4), PIK3R1(4), PSME1(2), RIPK3(5), RPS4X(2), SGCB(4), VASP(2)	37302013	245	168	241	62	29	80	52	25	58	1	0.0977	1.000	1.000
247	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	A4GALT(1), B3GALNT1(2), B3GALT1(5), B3GALT2(4), B3GALT4(1), B3GALT5(3), B3GNT1(3), B3GNT2(4), B3GNT3(5), B3GNT4(2), B3GNT5(5), B4GALNT1(9), B4GALT1(1), B4GALT2(4), B4GALT3(2), B4GALT4(2), B4GALT6(5), FUT1(4), FUT2(1), FUT3(5), FUT5(3), FUT6(4), FUT7(3), FUT9(15), GBGT1(2), GCNT2(5), PIGA(6), PIGB(5), PIGC(1), PIGG(13), PIGK(3), PIGL(4), PIGM(2), PIGN(10), PIGO(11), PIGP(2), PIGQ(6), PIGS(4), PIGT(7), PIGU(1), PIGV(4), PIGX(4), PIGZ(3), ST3GAL1(4), ST3GAL2(4), ST3GAL3(4), ST3GAL4(4), ST3GAL5(3), ST3GAL6(6), ST6GALNAC3(15), ST6GALNAC4(1), ST6GALNAC5(11), ST6GALNAC6(2), ST8SIA1(6), ST8SIA5(12), UGCG(2)	38645581	260	167	258	98	39	93	58	26	44	0	0.828	1.000	1.000
248	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(6), ARSB(6), FUCA1(2), FUCA2(3), GALNS(3), GBA(7), GLB1(3), GNS(1), GUSB(5), HEXA(6), HGSNAT(6), HPSE(4), HPSE2(16), HYAL1(3), HYAL2(3), IDS(7), IDUA(1), LCT(50), MAN2B1(5), MAN2B2(7), MAN2C1(7), MANBA(11), NAGLU(5), NEU1(2), NEU2(7), NEU3(5), NEU4(13), SPAM1(25)	27360330	219	167	218	78	30	98	35	27	29	0	0.682	1.000	1.000
249	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(4), ACTR3(2), ARHGAP1(5), ARHGAP4(14), ARHGAP5(17), ARHGAP6(17), ARHGEF1(5), ARHGEF11(24), ARHGEF5(4), ARPC1A(3), ARPC1B(4), ARPC2(3), ARPC3(2), BAIAP2(3), DIAPH1(3), GSN(4), LIMK1(3), MYL2(8), MYLK(26), OPHN1(16), PFN1(1), PIP5K1A(6), PIP5K1B(6), PPP1R12B(15), ROCK1(19), SRC(2), TLN1(15), VCL(8)	36548965	239	167	237	65	34	86	41	26	52	0	0.109	1.000	1.000
250	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(22), CARM1(4), CCND1(3), CREBBP(30), EP300(11), ERCC3(5), ESR1(12), GRIP1(13), GTF2A1(3), GTF2E1(8), GTF2F1(4), HDAC1(4), HDAC2(8), HDAC3(3), HDAC4(19), HDAC5(5), HDAC6(12), MEF2C(6), NCOR2(30), NR0B1(14), NRIP1(13), PELP1(10), POLR2A(11), TBP(1)	36770103	251	166	251	73	38	94	64	14	41	0	0.268	1.000	1.000
251	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	33	ADCY1(26), CALM1(3), CALM2(1), CREB1(2), ELK1(3), FOS(3), GNAI1(10), GNAQ(5), GNAS(29), GNB1(2), GNGT1(6), HRAS(2), JUN(3), MAP2K1(10), MAPK3(3), NFATC1(9), NFATC2(15), NFATC3(15), NFATC4(11), PLCG1(7), PPP3CB(3), PPP3CC(3), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PRKCA(10), RAF1(6), RPS6KA3(6), SYT1(6)	27060539	223	166	217	65	47	94	36	15	29	2	0.180	1.000	1.000
252	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(10), BAX(3), BCL2(5), BCL2A1(1), BCL2L1(3), CASP1(8), CASP10(7), CASP2(13), CASP3(5), CASP4(6), CASP6(3), CASP7(3), CASP8(6), CASP9(6), CD40(3), CD40LG(9), CRADD(3), CYCS(2), DAXX(8), DFFA(3), DFFB(4), FADD(2), FAS(4), FASLG(10), IKBKE(9), LTA(3), MCL1(1), NFKB1(6), NFKBIA(4), NGFR(5), NR3C1(8), NTRK1(14), PTPN13(21), RIPK1(11), TFG(4), TNF(2), TNFRSF1B(2), TRADD(2), TRAF1(2), TRAF2(5), TRAF3(4), TRAF6(6)	34956034	236	164	235	90	15	96	56	27	41	1	0.958	1.000	1.000
253	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(4), CDC7(6), CDK2(1), CDT1(1), DIAPH2(18), GMNN(1), MCM10(10), MCM2(5), MCM3(12), MCM4(11), MCM5(10), MCM6(16), MCM7(5), NACA(15), PCNA(1), POLA2(7), POLD1(7), POLD2(3), POLD3(2), POLD4(2), POLE(31), POLE2(1), PRIM1(3), RFC1(13), RFC2(4), RFC3(3), RFC4(7), RFC5(3), RPA1(2), RPA2(2), RPA3(1), RPA4(8), UBA52(1), UBC(14)	40583197	230	163	230	64	28	79	54	24	44	1	0.436	1.000	1.000
254	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	AGXT(8), AGXT2(13), ALAS1(2), ALAS2(6), AMT(1), AOC2(6), AOC3(11), ATP6V0C(4), BHMT(7), CBS(1), CHDH(2), CHKA(4), CHKB(4), CPT1B(6), CTH(2), DAO(7), DLD(9), DMGDH(11), GARS(3), GATM(8), GCAT(7), GLDC(26), MAOA(5), MAOB(3), PEMT(2), PISD(2), PLCB2(12), PLCG1(7), PLCG2(18), PSPH(6), SARDH(10), SARS(5), SHMT1(2), SHMT2(2), TARS(14)	33546941	236	163	234	81	41	76	53	29	36	1	0.551	1.000	1.000
255	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(4), AARS2(9), ABAT(12), ACY3(4), ADSL(2), ADSS(6), ADSSL1(4), AGXT(8), AGXT2(13), ASL(4), ASNS(8), ASPA(5), ASRGL1(3), ASS1(5), CAD(25), DARS(3), DARS2(4), DDO(5), DLAT(10), DLD(9), GAD1(7), GAD2(27), GOT1(3), GOT2(6), GPT2(5), NARS(4), NARS2(6), PC(9), PDHA1(5), PDHA2(29)	30242893	244	162	244	66	35	94	49	23	42	1	0.0995	1.000	1.000
256	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ACY3(4), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH3B1(2), ALDH3B2(4), ALDH7A1(3), ALDH9A1(3), AMDHD1(4), AOC2(6), AOC3(11), ASPA(5), CARM1(4), CNDP1(10), DDC(8), FTCD(8), HAL(5), HARS(5), HARS2(4), HDC(16), LCMT1(5), LCMT2(7), MAOA(5), MAOB(3), METTL2B(5), METTL6(1), PRMT2(2), PRMT3(8), PRMT5(7), PRMT6(7), PRMT7(4), PRMT8(13), PRPS1(3), PRPS2(4), UROC1(14), WBSCR22(3)	31764646	223	162	221	69	44	73	43	24	39	0	0.235	1.000	1.000
257	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	21	ARFIP2(5), CDK5(3), CDK5R1(3), CHN1(8), LIMK1(3), MAP3K1(7), MYL2(8), MYLK(26), NCF2(8), PAK1(9), PDGFRA(41), PIK3R1(4), PLD1(19), PPP1R12B(15), RALBP1(3), RPS6KB1(3), TRIO(37), VAV1(8), WASF1(10)	26477345	220	162	218	62	22	86	49	15	46	2	0.244	1.000	1.000
258	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	20	ATM(53), ATR(26), BRCA1(22), BRCA2(31), CHEK1(7), CHEK2(10), FANCA(7), FANCC(2), FANCD2(4), FANCE(3), FANCF(4), FANCG(7), HUS1(4), MRE11A(13), RAD1(1), RAD17(6), RAD50(10), RAD51(2), RAD9A(2), TREX1(1)	34908100	215	160	212	33	16	65	50	35	47	2	0.00220	1.000	1.000
259	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	24	AKR1B1(7), DCXR(1), GUSB(5), RPE(3), UGDH(6), UGP2(4), UGT1A1(12), UGT1A10(9), UGT1A3(6), UGT1A4(4), UGT1A5(8), UGT1A6(9), UGT1A7(7), UGT1A9(7), UGT2A1(16), UGT2A3(11), UGT2B10(9), UGT2B11(23), UGT2B15(14), UGT2B17(12), UGT2B4(28), UGT2B7(14), XYLB(6)	21297464	221	160	219	61	9	105	53	20	34	0	0.335	1.000	1.000
260	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(7), AKR1B10(10), ALDOA(4), ALDOB(8), ALDOC(2), FBP1(2), FBP2(2), FPGT(9), FUK(6), GMDS(9), GMPPA(7), HK1(12), HK2(11), HK3(22), HSD3B7(7), KHK(3), LHPP(3), MPI(4), MTMR1(11), MTMR2(2), MTMR6(9), PFKFB1(10), PFKFB2(2), PFKFB3(7), PFKFB4(6), PFKL(9), PFKM(7), PFKP(5), PGM2(8), PHPT1(1), PMM1(3), PMM2(1), RDH11(4), RDH12(3), RDH13(1), RDH14(2), SORD(2), TPI1(9), TSTA3(1)	29574893	231	160	230	64	46	85	44	18	38	0	0.0514	1.000	1.000
261	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(3), AASDH(15), AASDHPPT(4), AASS(20), ACAT1(2), ACAT2(2), ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH9A1(3), ATP6V0C(4), BBOX1(11), DLST(5), DOT1L(14), ECHS1(4), EHHADH(13), EHMT1(15), EHMT2(9), GCDH(7), HADHA(3), PLOD1(5), PLOD2(12), PLOD3(10), SDS(4), SHMT1(2), SHMT2(2), TMLHE(9)	29411929	224	160	221	62	30	87	49	28	29	1	0.157	1.000	1.000
262	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	29	AKT1(3), AKT2(7), AKT3(7), ANKRD6(2), APC(33), AXIN1(7), AXIN2(5), CER1(7), CSNK1A1(2), DACT1(24), DKK1(3), DKK2(14), DKK4(2), DVL1(5), FSTL1(4), GSK3A(1), GSK3B(4), LRP1(36), MVP(6), NKD1(6), NKD2(8), PIN1(1), PSEN1(6), PTPRA(11), SENP2(6), SFRP1(2), TSHB(5), WIF1(3)	30930555	220	160	217	73	34	92	34	19	41	0	0.601	1.000	1.000
263	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(10), CD2(6), CD33(13), CD5(7), IFNA1(2), IFNB1(7), IFNG(7), IL10(2), IL12A(2), IL12B(3), IL13(2), IL3(4), IL4(1), IL5(2), ITGAX(52), TLR2(10), TLR4(64), TLR7(17), TLR9(9)	15018623	220	159	219	65	19	111	35	21	32	2	0.0772	1.000	1.000
264	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	33	BLNK(2), BTK(25), CALM1(3), CALM2(1), CD79A(2), CD79B(2), ELK1(3), FOS(3), GRB2(6), HRAS(2), JUN(3), LYN(6), MAP2K1(10), MAP3K1(7), MAPK14(4), MAPK3(3), MAPK8(2), NFATC1(9), NFATC2(15), NFATC3(15), NFATC4(11), PLCG1(7), PPP3CB(3), PPP3CC(3), PRKCA(10), RAF1(6), SHC1(6), SOS1(17), SYK(5), SYT1(6), VAV1(8)	29895828	205	158	200	57	30	80	43	16	36	0	0.192	1.000	1.000
265	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	43	ABAT(12), ACAA2(2), ACADM(8), ACADS(1), ACAT1(2), ACAT2(2), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH6A1(2), ALDH7A1(3), ALDH9A1(3), AOX1(22), AUH(2), BCAT1(3), BCAT2(2), BCKDHA(1), DBT(8), DLD(9), ECHS1(4), EHHADH(13), HADH(2), HADHA(3), HADHB(10), HIBADH(2), HIBCH(4), HMGCL(1), HMGCS1(11), HMGCS2(7), HSD17B10(2), HSD17B4(8), IVD(4), MCCC1(5), MCCC2(5), MCEE(2), MUT(13), OXCT1(7), OXCT2(2), PCCA(6), PCCB(3)	34088869	226	158	224	65	23	71	64	23	44	1	0.510	1.000	1.000
266	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(20), ACAT1(2), ACAT2(2), ACYP2(1), ADH5(2), AKR1B1(7), ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH9A1(3), DLAT(10), DLD(9), GLO1(1), GRHPR(4), HAGH(4), HAGHL(3), LDHA(10), LDHB(4), LDHC(6), LDHD(2), MDH1(3), MDH2(3), ME1(3), ME2(9), ME3(8), PC(9), PCK1(21), PDHA1(5), PDHA2(29), PKLR(16)	29693112	242	158	241	64	34	93	45	28	42	0	0.0983	1.000	1.000
267	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(5), ALOX12(8), ALOX15(5), ALOX5(10), CYP4F2(15), CYP4F3(16), EPX(14), GGT1(1), LPO(7), LTA4H(3), MPO(15), PLA2G1B(2), PLA2G2A(5), PLA2G2E(2), PLA2G3(6), PLA2G4A(21), PLA2G6(3), PRDX1(4), PRDX2(2), PRDX5(1), PRDX6(5), PTGDS(4), PTGIS(12), PTGS1(18), PTGS2(12), TBXAS1(11), TPO(33)	22337017	240	157	236	76	38	81	61	25	35	0	0.344	1.000	1.000
268	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	27	ARHGDIB(2), CASP2(13), CASP3(5), CASP8(6), CRADD(3), DFFA(3), DFFB(4), FADD(2), JUN(3), LMNA(2), LMNB1(5), LMNB2(5), MADD(22), MAP2K4(8), MAP3K1(7), MAP3K7(10), MAPK8(2), PAK1(9), PAK2(3), PRKDC(50), RIPK1(11), SPTAN1(21), TNF(2), TRADD(2), TRAF2(5)	29556400	205	157	201	46	19	58	54	25	49	0	0.0900	1.000	1.000
269	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2A1(3), GTF2A1L(10), GTF2A2(1), GTF2B(1), GTF2E1(8), GTF2E2(2), GTF2F1(4), GTF2H1(4), GTF2H3(1), GTF2H4(1), GTF2I(7), GTF2IRD1(10), STON1(11), TAF1(22), TAF1L(65), TAF2(13), TAF4(13), TAF4B(6), TAF5(5), TAF5L(9), TAF6(3), TAF6L(3), TAF7(3), TAF7L(6), TAF9(3), TAF9B(5), TBPL1(1), TBPL2(4)	29022582	224	156	224	51	28	81	49	21	43	2	0.0807	1.000	1.000
270	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	ATF2(10), CDC42(1), CREB1(2), DAXX(8), DDIT3(2), ELK1(3), GRB2(6), HMGN1(1), HRAS(2), HSPB1(1), HSPB2(1), MAP2K4(8), MAP2K6(5), MAP3K1(7), MAP3K5(14), MAP3K7(10), MAP3K9(17), MAPK14(4), MAPKAPK2(2), MAPKAPK5(5), MAX(8), MEF2A(2), MEF2B(2), MEF2C(6), MEF2D(4), MKNK1(4), MYC(4), PLA2G4A(21), RIPK1(11), RPS6KA5(10), SHC1(6), STAT1(7), TGFB1(3), TGFB2(10), TGFBR1(7), TRADD(2), TRAF2(5)	29475986	221	156	220	49	21	88	46	22	44	0	0.0357	1.000	1.000
271	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	24	AKT1(3), APC(33), AXIN1(7), CCND1(3), CD14(1), DVL1(5), FZD1(6), GJA1(11), GNAI1(10), GSK3B(4), IRAK1(6), LBP(8), LEF1(12), LY96(3), MYD88(1), NFKB1(6), PDPK1(3), PIK3R1(4), PPP2CA(1), RELA(3), TLR4(64), TOLLIP(2), WNT1(6)	21417618	202	155	199	53	24	85	31	17	45	0	0.122	1.000	1.000
272	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	ANKHD1(21), EEF1A2(8), EEF1B2(7), EEF1D(2), EEF1G(2), EEF2(7), EEF2K(7), EIF1AX(3), EIF2AK1(12), EIF2AK2(5), EIF2AK3(12), EIF2B1(2), EIF2B2(3), EIF2B3(4), EIF2B4(3), EIF2S2(3), EIF2S3(3), EIF4A1(2), EIF4A2(7), EIF4E(4), EIF4EBP2(1), EIF4G1(19), EIF4G3(20), EIF5(1), EIF5A(2), EIF5B(14), GSPT2(8), PABPC1(5), PABPC3(15), PAIP1(6), SLC35A4(1)	34830836	209	155	208	54	16	79	55	25	34	0	0.246	1.000	1.000
273	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	26	ARHGDIB(2), CASP10(7), CASP3(5), CASP6(3), CASP7(3), CASP8(6), CFLAR(2), DAXX(8), DFFA(3), DFFB(4), FADD(2), FAF1(10), JUN(3), LMNA(2), LMNB1(5), LMNB2(5), MAP2K4(8), MAP3K1(7), MAP3K7(10), MAPK8(2), PAK1(9), PAK2(3), PRKDC(50), PTPN13(21), RIPK2(2), SPTAN1(21)	31228628	203	154	199	54	13	59	52	27	52	0	0.533	1.000	1.000
274	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	28	ELK1(3), GNAS(29), GNB1(2), GNGT1(6), GRB2(6), HRAS(2), IGF1R(8), ITGB1(6), KLK2(10), MAP2K1(10), MAP2K2(1), MAPK1(2), MAPK3(3), MKNK1(4), MKNK2(2), MYC(4), NGFR(5), PDGFRA(41), PPP2CA(1), PTPRR(16), RAF1(6), RPS6KA1(6), RPS6KA5(10), SHC1(6), SOS1(17), SRC(2), STAT3(11)	24347074	219	153	210	61	32	91	43	24	28	1	0.222	1.000	1.000
275	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA2(2), ACAD8(7), ACAD9(5), ADH1A(8), ADH1B(12), ADH4(4), ADH5(2), ADH6(8), ADH7(11), ADHFE1(5), AKR1B10(10), AKR1C4(4), AKR1D1(12), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH7A1(3), ALDH9A1(3), BAAT(9), CEL(8), CYP27A1(5), CYP7A1(8), HADHB(10), HSD3B7(7), LIPA(2), RDH11(4), RDH12(3), RDH13(1), RDH14(2), SLC27A5(7), SOAT1(8), SOAT2(2), SRD5A1(4)	25394461	206	153	203	63	19	81	48	22	36	0	0.368	1.000	1.000
276	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSA(2), ARSD(6), ARSE(5), ASAH1(3), B4GALT6(5), CERK(4), DEGS1(2), DEGS2(1), ENPP7(11), GAL3ST1(7), GALC(9), GBA(7), GLA(9), GLB1(3), LCT(50), NEU1(2), NEU2(7), NEU3(5), NEU4(13), PPAP2A(2), PPAP2B(3), PPAP2C(1), SGMS1(4), SGMS2(3), SGPP1(3), SGPP2(2), SMPD1(3), SMPD3(6), SMPD4(13), SPHK2(4), SPTLC1(3), SPTLC2(3), UGCG(2), UGT8(8)	28419660	211	152	209	67	37	99	42	11	22	0	0.198	1.000	1.000
277	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ADH1A(8), ADH1B(12), ADH4(4), ADH6(8), ADH7(11), ADHFE1(5), ALDH1A3(4), ALDH3A1(5), ALDH3B1(2), ALDH3B2(4), AOC2(6), AOC3(11), AOX1(22), COMT(1), DBH(12), DCT(16), DDC(8), FAH(2), GOT1(3), GOT2(6), GSTZ1(2), HGD(5), HPD(2), MAOA(5), MAOB(3), PNMT(1), TAT(9), TH(7), TPO(33), TYR(29)	25458965	246	152	243	80	38	97	35	28	48	0	0.292	1.000	1.000
278	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	18	ADCY1(26), ARHGEF1(5), F2(9), F2R(10), F2RL3(2), GNA12(1), GNA13(6), GNAI1(10), GNAQ(5), GNB1(2), GNGT1(6), MAP3K7(10), PIK3R1(4), PLCB1(52), PPP1R12B(15), PRKCA(10), PTK2B(14), ROCK1(19)	18943047	206	151	204	47	27	88	33	16	41	1	0.0112	1.000	1.000
279	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	25	CSNK2A1(5), ELK1(3), FOS(3), GRB2(6), HRAS(2), JAK1(11), JUN(3), MAP2K1(10), MAP2K4(8), MAP3K1(7), MAPK3(3), MAPK8(2), PDGFA(5), PDGFRA(41), PIK3R1(4), PLCG1(7), PRKCA(10), RAF1(6), RASA1(11), SHC1(6), SOS1(17), SRF(1), STAT1(7), STAT3(11), STAT5A(3)	26414089	192	151	187	54	26	55	38	26	46	1	0.400	1.000	1.000
280	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(9), AGT(4), AGTR1(9), AGTR2(6), CMA1(8), COL4A1(36), COL4A2(40), COL4A3(16), COL4A4(22), COL4A5(50), COL4A6(28), REN(6)	20378769	234	149	233	81	20	133	35	13	32	1	0.955	1.000	1.000
281	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(12), ACACA(20), ACACB(28), ACADM(8), ACAT1(2), ACAT2(2), ACSS1(5), ACSS2(4), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH6A1(2), ALDH7A1(3), ALDH9A1(3), ECHS1(4), EHHADH(13), HADHA(3), HIBCH(4), LDHA(10), LDHAL6A(1), LDHAL6B(3), LDHB(4), LDHC(6), MCEE(2), MLYCD(2), MUT(13), PCCA(6), PCCB(3), SUCLA2(5), SUCLG1(5), SUCLG2(1)	31991829	204	149	203	69	26	74	43	17	44	0	0.819	1.000	1.000
282	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(6), ACTG2(10), ADCY3(7), ADCY9(12), ARF1(1), ARF3(1), ARF5(2), ARF6(1), ARL4D(4), ATP6V0A1(6), ATP6V0A2(4), ATP6V0A4(8), ATP6V0B(2), ATP6V0C(4), ATP6V0D1(2), ATP6V0D2(8), ATP6V1A(6), ATP6V1C1(7), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1E2(5), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3), ERO1L(5), GNAS(29), PDIA4(8), PLCG1(7), PLCG2(18), PRKCA(10), SEC61A1(5), SEC61A2(6), SEC61G(3), TRIM23(4)	29658651	204	148	198	65	34	79	40	16	34	1	0.397	1.000	1.000
283	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	ATF2(10), BCR(11), BLNK(2), ELK1(3), FOS(3), GRB2(6), HRAS(2), JUN(3), LYN(6), MAP2K1(10), MAP3K1(7), MAPK1(2), MAPK3(3), MAPK8IP3(7), PAPPA(32), RPS6KA1(6), RPS6KA3(6), SHC1(6), SOS1(17), SYK(5), VAV1(8), VAV2(8), VAV3(32)	25525164	195	148	191	51	25	71	39	24	35	1	0.120	1.000	1.000
284	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(11), GABRA1(20), GABRA2(31), GABRA3(15), GABRA4(39), GABRA5(27), GABRA6(28), GPHN(5), NSF(4), SRC(2), UBQLN1(6)	9626774	188	146	185	62	23	91	33	19	22	0	0.612	1.000	1.000
285	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	15	C3(13), C5(6), C6(29), ICAM1(2), IL1A(4), IL6(2), ITGA4(38), ITGAL(26), ITGB1(6), ITGB2(8), SELP(29), SELPLG(2), TNF(2), VCAM1(28)	18720064	195	146	195	64	14	80	50	19	31	1	0.746	1.000	1.000
286	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(9), F2R(10), F2RL3(2), GNAI1(10), GNB1(2), GNGT1(6), HRAS(2), ITGA1(14), ITGB1(6), MAP2K1(10), MAPK1(2), MAPK3(3), PLA2G4A(21), PLCB1(52), PRKCA(10), PTGS1(18), PTK2(6), RAF1(6), SRC(2), SYK(5), TBXAS1(11)	19547606	207	146	202	46	21	94	41	20	31	0	0.0126	1.000	1.000
287	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(26), CD3D(2), CD3E(2), CD4(8), CREBBP(30), CSK(2), GNAS(29), GNB1(2), GNGT1(6), HLA-DRA(3), HLA-DRB1(5), LCK(9), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PTPRC(41), ZAP70(9)	18346764	198	144	191	55	40	70	37	12	37	2	0.243	1.000	1.000
288	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCL11(2), CCR3(4), GNAQ(5), GNAS(29), GNB1(2), GNGT1(6), HRAS(2), LIMK1(3), MAP2K1(10), MAPK1(2), MAPK3(3), MYL2(8), NOX1(8), PIK3C2G(19), PLCB1(52), PPP1R12B(15), PRKCA(10), PTK2(6), RAF1(6), ROCK2(9)	20171859	201	144	194	43	32	84	39	18	28	0	0.0272	1.000	1.000
289	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(26), CD3D(2), CD3E(2), CD4(8), CREBBP(30), CSK(2), GNAS(29), GNB1(2), GNGT1(6), HLA-DRA(3), HLA-DRB1(5), LCK(9), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PTPRC(41), ZAP70(9)	18346764	198	144	191	55	40	70	37	12	37	2	0.243	1.000	1.000
290	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	21	ADCY1(26), AKT1(3), ASAH1(3), GNAI1(10), GNB1(2), GNGT1(6), ITGAV(14), ITGB3(13), MAPK1(2), MAPK3(3), PDGFA(5), PDGFRA(41), PIK3R1(4), PLCB1(52), PRKCA(10), PTK2(6), SMPD1(3), SRC(2)	20281668	205	144	203	63	22	84	43	17	37	2	0.322	1.000	1.000
291	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(1), ASNS(8), ASRGL1(3), CA1(6), CA12(2), CA13(1), CA14(3), CA2(2), CA3(10), CA4(6), CA5A(2), CA5B(3), CA6(4), CA7(1), CA8(5), CA9(9), CPS1(71), CTH(2), GLS(8), GLS2(6), GLUD1(4), GLUD2(15), GLUL(6), HAL(5)	17120398	183	144	182	58	17	80	31	23	32	0	0.590	1.000	1.000
292	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(12), ANAPC10(1), ANAPC11(1), ANAPC2(5), ANAPC4(6), ANAPC5(8), ANAPC7(5), BTRC(12), CDC16(2), CDC20(8), CDC23(3), CDC27(7), CUL1(14), CUL2(8), CUL3(13), FBXW11(2), FBXW7(15), FZR1(3), ITCH(8), SKP1(4), SKP2(3), SMURF1(8), SMURF2(4), TCEB1(2), UBA1(4), UBE2C(3), UBE2D1(1), UBE2D2(1), UBE2D3(3), UBE2D4(1), UBE2E2(4), UBE2E3(6), VHL(1), WWP1(13), WWP2(7)	32170628	198	144	197	46	27	61	41	31	38	0	0.0754	1.000	1.000
293	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(4), AKT1(3), AKT2(7), AKT3(7), DAG1(3), GNAQ(5), ITPKA(2), ITPKB(7), ITPR1(20), ITPR2(40), ITPR3(21), NFKB1(6), NFKB2(5), NFKBIA(4), NFKBIB(3), NFKBIE(2), NFKBIL1(1), PDK1(6), PHKA2(14), PIK3CB(8), PITX2(8), PLD1(19), PLD2(7), PLD3(4), VN1R1(2)	35811416	208	144	207	59	23	79	43	19	43	1	0.281	1.000	1.000
294	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(3), CAMK2B(16), CAMK2D(7), DAG1(3), ITPKA(2), ITPKB(7), ITPR1(20), ITPR2(40), ITPR3(21), NFAT5(13), PDE6A(17), PDE6B(15), PDE6C(12), PDE6G(3), SLC6A13(12), TF(13)	28645135	204	144	203	62	28	73	49	20	33	1	0.384	1.000	1.000
295	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	31	A1BG(4), AKT1(3), AKT2(7), AKT3(7), BTK(25), DAPP1(3), GRB2(6), GSK3A(1), GSK3B(4), IARS(9), IGFBP1(6), INPP5D(11), PDK1(6), PPP1R13B(7), PTEN(11), RPS6KA1(6), RPS6KA2(8), RPS6KA3(6), RPS6KB1(3), SFN(1), SHC1(6), SOS1(17), SOS2(13), TEC(12), YWHAB(1), YWHAE(1), YWHAG(3), YWHAH(1), YWHAQ(4), YWHAZ(2)	26754860	194	143	191	49	20	78	44	14	38	0	0.154	1.000	1.000
296	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	24	ARNT(5), EIF1(2), EIF2B1(2), EIF2B2(3), EIF2B3(4), EIF2B4(3), EIF2S2(3), EIF2S3(3), ELAVL1(5), FLT1(31), FLT4(20), HIF1A(2), HRAS(2), KDR(56), NOS3(12), PIK3R1(4), PLCG1(7), PRKCA(10), PTK2(6), PXN(1), SHC1(6), VHL(1)	25304018	188	143	185	55	30	71	32	18	37	0	0.297	1.000	1.000
297	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(12), ACADL(4), ACADM(8), ACADSB(2), ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH9A1(3), AOC2(6), AOC3(11), CNDP1(10), DPYD(24), DPYS(22), ECHS1(4), EHHADH(13), GAD1(7), GAD2(27), HADHA(3), MLYCD(2), SDS(4), SMS(3), UPB1(2)	23401329	213	141	211	52	26	84	39	22	41	1	0.0375	1.000	1.000
298	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	25	AKT1(3), AKT2(7), AKT3(7), CISH(1), GRB2(6), IARS(9), IL13RA1(3), IL2RG(5), IL4(1), IL4R(10), INPP5D(11), JAK1(11), JAK2(16), JAK3(10), NR0B2(3), PI3(1), PPP1R13B(7), RPS6KB1(3), SERPINA4(16), SHC1(6), SOS1(17), SOS2(13), SRC(2), STAT6(2), TYK2(5)	27775707	175	141	171	63	23	67	39	20	26	0	0.849	1.000	1.000
299	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(36), COL4A2(40), COL4A3(16), COL4A4(22), COL4A5(50), COL4A6(28), P4HB(5), SLC23A1(3), SLC23A2(8), SLC2A1(1), SLC2A3(10)	20161255	219	140	218	71	23	119	34	10	32	1	0.753	1.000	1.000
300	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(13), ATP5E(1), ATP5O(1), ATP6AP1(3), ATP6V0A1(6), ATP6V0A4(8), ATP6V0B(2), ATP6V0C(4), ATP6V0D1(2), ATP6V1A(6), ATP6V1B1(3), ATP6V1B2(5), ATP6V1C1(7), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3), ATP7A(29), ATP7B(22), COX10(4), COX4I1(3), COX5A(1), COX5B(2), COX6B1(2), COX6C(1), COX8A(1), NDUFA1(2), NDUFA10(5), NDUFA11(1), NDUFA4(2), NDUFA5(2), NDUFA8(5), NDUFB2(2), NDUFB4(1), NDUFB5(6), NDUFB6(2), NDUFS1(10), NDUFS2(4), NDUFV1(2), NDUFV2(1), SDHA(8), SDHB(1), SHMT1(2), UQCRB(5), UQCRC1(2), UQCRFS1(3), UQCRH(3)	30733115	208	139	205	78	34	79	30	22	41	2	0.800	1.000	1.000
301	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(14), ABAT(12), ACADS(1), ACAT1(2), ACAT2(2), ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH5A1(2), ALDH9A1(3), ECHS1(4), EHHADH(13), GAD1(7), GAD2(27), HADHA(3), HMGCL(1), L2HGDH(6), OXCT1(7), PDHA1(5), PDHA2(29), SDHB(1), SDS(4)	20733189	189	138	188	58	22	70	40	20	36	1	0.460	1.000	1.000
302	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(3), ACO1(5), ACO2(3), CLYBL(5), CS(2), DLD(9), DLST(5), FH(13), IDH1(6), IDH2(2), IDH3A(1), IDH3B(4), IDH3G(5), MDH1(3), MDH2(3), OGDH(10), OGDHL(35), PC(9), PCK1(21), PCK2(4), SDHA(8), SDHB(1), SDHD(3), SUCLA2(5), SUCLG1(5), SUCLG2(1)	24111107	171	138	170	65	28	61	24	25	33	0	0.761	1.000	1.000
303	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	23	POLA1(19), POLA2(7), POLB(4), POLD1(7), POLD2(3), POLD3(2), POLD4(2), POLE(31), POLE2(1), POLE4(1), POLG(12), POLG2(3), POLH(1), POLI(3), POLK(3), POLL(7), POLM(6), POLQ(36), PRIM1(3), REV1(10), REV3L(20), RFC5(3)	31959465	184	138	183	49	22	71	45	23	23	0	0.367	1.000	1.000
304	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	32	AGT(4), AGTR1(9), ATF2(10), CALM1(3), CALM2(1), ELK1(3), GNAQ(5), GRB2(6), HRAS(2), JUN(3), MAP2K1(10), MAP2K2(1), MAP2K4(8), MAP3K1(7), MAPK1(2), MAPK3(3), MAPK8(2), MEF2A(2), MEF2B(2), MEF2C(6), MEF2D(4), PAK1(9), PRKCA(10), PTK2(6), PTK2B(14), RAF1(6), SHC1(6), SOS1(17), SRC(2), SYT1(6)	24812007	169	137	162	47	24	65	24	18	38	0	0.314	1.000	1.000
305	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(9), EPHA4(18), EPHB1(44), FYN(8), ITGA1(14), ITGB1(6), L1CAM(42), LYN(6), RAP1B(2), SELP(29)	12772799	178	137	177	47	28	68	33	22	25	2	0.131	1.000	1.000
306	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(12), ACACA(20), ACADL(4), ACADM(8), ACADSB(2), ACAT1(2), ACAT2(2), ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH6A1(2), ALDH9A1(3), ECHS1(4), EHHADH(13), HADHA(3), LDHA(10), LDHB(4), LDHC(6), MCEE(2), MLYCD(2), MUT(13), PCCA(6), PCCB(3), SDS(4), SUCLA2(5), SUCLG1(5), SUCLG2(1)	26690520	182	137	181	50	19	62	40	19	42	0	0.418	1.000	1.000
307	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(3), ATF1(1), CDC42(1), CREB1(2), CREB5(18), DUSP1(1), DUSP10(11), EEF2K(7), EIF4E(4), ELK1(3), GADD45A(2), HSPB1(1), IL1R1(2), MAP2K3(13), MAP2K4(8), MAP2K6(5), MAP3K10(4), MAP3K4(21), MAP3K5(14), MAP3K7(10), MAPK1(2), MAPK12(2), MAPK13(1), MAPK14(4), MAPKAPK2(2), MAPKAPK5(5), MKNK1(4), MKNK2(2), MYEF2(12), NFKB1(6), NR2C2(2), SRF(1), TRAF6(6)	26680683	180	137	178	47	16	76	36	13	39	0	0.177	1.000	1.000
308	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA1(1), ANXA2(2), ANXA3(6), ANXA4(5), ANXA5(6), ANXA6(8), CYP11A1(5), EDN1(1), EDNRA(3), EDNRB(16), HPGD(5), HSD11B1(9), PLA2G4A(21), PRL(3), PTGDR(8), PTGDS(4), PTGER2(4), PTGER4(7), PTGFR(12), PTGIR(6), PTGIS(12), PTGS1(18), PTGS2(12), S100A6(1), SCGB1A1(2), TBXAS1(11)	16642391	188	135	186	48	25	67	44	17	33	2	0.0756	1.000	1.000
309	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	18	ABL1(9), ATM(53), BRCA1(22), CDKN1A(2), CHEK1(7), CHEK2(10), GADD45A(2), JUN(3), MAPK8(2), MDM2(5), MRE11A(13), NFKB1(6), NFKBIA(4), RAD50(10), RAD51(2), RBBP8(6), RELA(3), TP73(7)	23295621	166	134	162	31	17	47	37	23	40	2	0.0630	1.000	1.000
310	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	40	APAF1(10), BAK1(3), BAX(3), BCL2(5), BCL2L1(3), BID(2), BIRC2(2), BIRC3(4), CASP2(13), CASP3(5), CASP6(3), CASP7(3), CASP8(6), CASP9(6), CYCS(2), FADD(2), FAS(4), FASLG(10), GZMB(6), JUN(3), MAP2K4(8), MAP3K1(7), MAPK10(6), MCL1(1), MDM2(5), MYC(4), NFKB1(6), NFKBIA(4), PARP1(4), PRF1(8), RELA(3), RIPK1(11), TNF(2), TNFRSF1B(2), TNFSF10(3), TRADD(2), TRAF1(2), TRAF2(5)	29395614	178	133	178	64	13	75	40	19	31	0	0.869	1.000	1.000
311	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	25	ADCY1(26), AKT1(3), CAMK2A(3), CAMK2B(16), CAMK2D(7), CREB1(2), GNAS(29), GRB2(6), HRAS(2), MAPK1(2), MAPK14(4), MAPK3(3), PIK3R1(4), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PRKCA(10), RPS6KA1(6), RPS6KA5(10), SOS1(17)	21506548	174	133	168	56	36	65	31	18	22	2	0.622	1.000	1.000
312	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ACY1(2), AGMAT(2), ALDH18A1(3), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH7A1(3), ALDH9A1(3), AMD1(2), AOC2(6), AOC3(11), ARG1(2), ASL(4), ASS1(5), CPS1(71), GATM(8), MAOA(5), MAOB(3), NAGS(1), ODC1(1), OTC(10), SAT1(3), SMS(3), SRM(2)	23626242	180	133	179	60	22	68	35	25	29	1	0.593	1.000	1.000
313	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(12), ACADM(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH7A1(3), ALDH9A1(3), AOC2(6), AOC3(11), CNDP1(10), DPYD(24), DPYS(22), ECHS1(4), EHHADH(13), GAD1(7), GAD2(27), HADHA(3), HIBCH(4), MLYCD(2), SMS(3), SRM(2), UPB1(2)	21711201	196	133	194	48	26	78	39	17	35	1	0.0425	1.000	1.000
314	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(1), ASNS(8), CA1(6), CA12(2), CA14(3), CA2(2), CA3(10), CA4(6), CA5A(2), CA5B(3), CA6(4), CA7(1), CA8(5), CA9(9), CPS1(71), CTH(2), GLS(8), GLS2(6), GLUD1(4), GLUL(6), HAL(5)	15322390	164	133	163	49	17	67	27	22	31	0	0.468	1.000	1.000
315	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	35	ACAA2(2), ACADL(4), ACADM(8), ACADS(1), ACADSB(2), ACAT1(2), ACAT2(2), ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH6A1(2), ALDH9A1(3), AOX1(22), BCAT1(3), BCKDHA(1), ECHS1(4), EHHADH(13), HADHA(3), HADHB(10), HIBADH(2), HMGCL(1), IVD(4), MCCC1(5), MCCC2(5), MCEE(2), MUT(13), OXCT1(7), PCCA(6), PCCB(3), SDS(4)	28405135	180	133	179	55	16	61	45	22	36	0	0.666	1.000	1.000
316	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	39	ARNTL(2), AZIN1(4), BTG1(3), CBX3(4), CLOCK(4), CRY1(7), CRY2(6), DAZAP2(1), DNAJA1(3), EIF4G2(5), ETV6(5), GFRA1(20), GSTM3(2), GSTP1(2), HERPUD1(2), HSPA8(10), IDI1(2), MYF6(11), NCKAP1(11), NCOA4(6), NR1D2(1), PER1(10), PER2(11), PPP1R3C(3), PPP2CB(3), PSMA4(2), PURA(2), SF3A3(2), SUMO3(5), TOB1(4), TUBB3(3), UGP2(4), VAPA(2), ZFR(10)	29207628	172	132	171	45	20	60	39	16	36	1	0.315	1.000	1.000
317	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(20), GABRA2(31), GABRA3(15), GABRA4(39), GABRA5(27), GABRA6(28), PRKCE(5), SOD1(1)	6364786	166	132	163	55	16	85	30	16	18	1	0.611	1.000	1.000
318	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(4), ACP2(4), ACP5(4), ACPP(8), ACPT(7), ALPI(9), ALPL(3), ALPP(13), ALPPL2(4), CYP19A1(4), CYP1A1(9), CYP1A2(3), CYP2A13(13), CYP2A6(6), CYP2A7(7), CYP2B6(10), CYP2C18(7), CYP2C19(13), CYP2C8(2), CYP2C9(8), CYP2D6(1), CYP2E1(7), CYP2F1(3), CYP2J2(1), CYP3A4(4), CYP3A5(5), CYP3A7(7), CYP4B1(14), CYP51A1(5), PON1(3)	23543387	188	132	188	72	25	72	38	23	30	0	0.818	1.000	1.000
319	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	21	ARHGAP5(17), DIAPH1(3), FYN(8), GSN(4), HRAS(2), ITGA1(14), ITGB1(6), MAP2K1(10), MAPK1(2), MAPK3(3), MYL2(8), MYLK(26), PFN1(1), PIK3R1(4), PTK2(6), PXN(1), RAF1(6), ROCK1(19), SHC1(6), SRC(2), TLN1(15)	28343809	163	130	160	52	22	57	28	23	33	0	0.606	1.000	1.000
320	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	22	ABL1(9), ATM(53), ATR(26), CCNA1(7), CCND1(3), CCNE1(7), CDC25A(4), CDK2(1), CDK4(3), CDK6(5), CDKN1A(2), CDKN1B(5), DHFR(2), E2F1(3), GSK3B(4), HDAC1(4), SKP2(3), TFDP1(10), TGFB1(3), TGFB2(10)	21749566	164	130	160	34	18	52	31	21	40	2	0.0543	1.000	1.000
321	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(1), BLVRA(3), BLVRB(2), CP(11), CPOX(4), EPRS(27), FECH(4), GUSB(5), HCCS(3), HMBS(5), HMOX1(3), PPOX(7), UGT1A1(12), UGT1A10(9), UGT1A3(6), UGT1A4(4), UGT1A5(8), UGT1A6(9), UGT1A7(7), UGT1A9(7), UGT2B15(14), UGT2B4(28), UROS(2)	22183495	181	130	180	51	9	88	47	12	25	0	0.356	1.000	1.000
322	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	24	CSNK2A1(5), EGF(13), ELK1(3), FOS(3), GRB2(6), HRAS(2), JAK1(11), JUN(3), MAP2K1(10), MAP2K4(8), MAP3K1(7), MAPK3(3), MAPK8(2), PIK3R1(4), PLCG1(7), PRKCA(10), RAF1(6), RASA1(11), SHC1(6), SOS1(17), SRF(1), STAT1(7), STAT3(11), STAT5A(3)	26366328	159	128	153	45	21	44	29	24	41	0	0.513	1.000	1.000
323	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	24	GH1(7), GHR(19), GRB2(6), HRAS(2), INSR(10), IRS1(20), JAK2(16), MAP2K1(10), MAPK1(2), MAPK3(3), PIK3R1(4), PLCG1(7), PRKCA(10), PTPN6(6), RAF1(6), RPS6KA1(6), SHC1(6), SLC2A4(4), SOS1(17), SRF(1), STAT5A(3), STAT5B(8)	24824509	173	128	168	51	29	59	37	22	26	0	0.299	1.000	1.000
324	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(8), EXT2(11), EXTL1(8), EXTL2(3), EXTL3(13), GLCE(4), HS2ST1(1), HS3ST1(8), HS3ST2(7), HS3ST3A1(7), HS3ST5(18), HS6ST1(5), HS6ST2(3), HS6ST3(12), NDST1(6), NDST2(6), NDST3(16), NDST4(36)	16652374	172	128	170	49	31	58	41	23	17	2	0.217	1.000	1.000
325	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(17), ARHGEF1(5), GNA12(1), GNA13(6), GNAQ(5), GNB1(2), GNGT1(6), MYL2(8), MYLK(26), PLCB1(52), PPP1R12B(15), PRKCA(10), ROCK1(19)	16694901	172	128	171	40	18	73	28	20	33	0	0.0587	1.000	1.000
326	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	21	CSNK2A1(5), FOS(3), GRB2(6), HRAS(2), JAK2(16), JUN(3), MAP2K1(10), MAPK3(3), MPL(5), PIK3R1(4), PLCG1(7), PRKCA(10), RAF1(6), RASA1(11), SHC1(6), SOS1(17), STAT1(7), STAT3(11), STAT5A(3), STAT5B(8), THPO(7)	22394846	150	128	145	46	19	44	27	23	37	0	0.647	1.000	1.000
327	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(3), CHIA(5), CHIT1(11), CMAS(10), CYB5R1(1), GFPT1(8), GFPT2(10), GNE(2), GNPDA1(2), GNPDA2(2), GNPNAT1(1), HEXA(6), HK1(12), HK2(11), HK3(22), LHPP(3), MTMR1(11), MTMR2(2), MTMR6(9), NAGK(6), NANS(2), NPL(4), PGM3(3), PHPT1(1), RENBP(7), UAP1(7)	23026251	161	127	160	42	29	63	26	19	24	0	0.100	1.000	1.000
328	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	33	AKT1(3), BCL2(5), BCL2L1(3), CBL(10), CFLAR(2), CRKL(4), E2F1(3), FOS(3), GRB2(6), HRAS(2), IL2RA(6), IL2RB(7), IL2RG(5), IRS1(20), JAK1(11), JAK3(10), MAPK1(2), MAPK3(3), MYC(4), NMI(2), PIK3R1(4), PTPN6(6), RAF1(6), RPS6KB1(3), SHC1(6), SOS1(17), STAT5A(3), STAT5B(8), SYK(5)	27177136	169	127	164	59	28	54	43	20	24	0	0.746	1.000	1.000
329	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	13	APC(33), AXIN1(7), CREBBP(30), DVL1(5), EP300(11), FZD1(6), GSK3B(4), HDAC1(4), LDB1(3), LEF1(12), PITX2(8), TRRAP(51), WNT1(6)	25309528	180	127	178	40	40	52	37	15	36	0	0.0239	1.000	1.000
330	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(3), CALM1(3), CALM2(1), CRKL(4), GNAQ(5), GRB2(6), HRAS(2), JUN(3), MAP2K1(10), MAP2K2(1), MAP2K3(13), MAP2K4(8), MAP3K1(7), MAPK1(2), MAPK14(4), MAPK3(3), MAPK8(2), PAK1(9), PLCG1(7), PRKCA(10), PTK2B(14), RAF1(6), SHC1(6), SOS1(17), SRC(2), SYT1(6)	22790036	154	127	147	48	24	53	30	12	35	0	0.575	1.000	1.000
331	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOA(4), ALDOB(8), ALDOC(2), FBP1(2), FBP2(2), GOT1(3), GOT2(6), GPT2(5), MDH1(3), MDH2(3), ME1(3), ME3(8), PGK1(4), PGK2(27), PKLR(16), RPE(3), RPIA(8), TKT(3), TKTL1(14), TKTL2(26), TPI1(9)	16185365	159	126	159	34	18	62	33	18	28	0	0.00969	1.000	1.000
332	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	CHUK(7), FADD(2), IKBKB(9), IL1A(4), IL1R1(2), IRAK1(6), MAP3K1(7), MAP3K7(10), MYD88(1), NFKB1(6), NFKBIA(4), RELA(3), RIPK1(11), TLR4(64), TNF(2), TNFAIP3(6), TNFRSF1B(2), TRADD(2), TRAF6(6)	19518685	154	126	153	48	5	65	34	19	31	0	0.602	1.000	1.000
333	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	25	AKT1(3), AKT2(7), AKT3(7), BCL2(5), GRB2(6), GSK3A(1), GSK3B(4), IL4R(10), IRS1(20), JAK1(11), JAK3(10), MAP4K1(12), MAPK1(2), MAPK3(3), PDK1(6), PIK3CD(4), PIK3R1(4), PPP1R13B(7), RAF1(6), SHC1(6), SOS1(17), SOS2(13), STAT6(2)	26813232	166	125	161	62	24	61	37	17	27	0	0.871	1.000	1.000
334	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	17	CBL(10), EGF(13), GRB2(6), HRAS(2), MAP2K1(10), MAPK1(2), MAPK3(3), PTPRB(50), RAF1(6), RASA1(11), SHC1(6), SOS1(17), SPRY1(3), SPRY2(5), SPRY3(9), SPRY4(4), SRC(2)	18022937	159	124	153	50	17	54	36	18	34	0	0.774	1.000	1.000
335	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(25), DLG4(7), EPHB2(10), F2(9), F2RL1(2), F2RL2(12), F2RL3(2), JUN(3), MAP2K5(4), MAPK1(2), MAPK7(7), MAPK8(2), MYEF2(12), PLD1(19), PLD2(7), PLD3(4), PTK2(6), RAF1(6), RASAL1(10), SRC(2), TEC(12), VAV1(8)	21952267	171	124	169	38	21	70	41	8	31	0	0.0142	1.000	1.000
336	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(7), ALDOA(4), ALDOB(8), ALDOC(2), FBP1(2), FBP2(2), FPGT(9), GCK(6), GMDS(9), GMPPA(7), HK1(12), HK2(11), HK3(22), KHK(3), MPI(4), PFKFB1(10), PFKFB3(7), PFKFB4(6), PFKM(7), PFKP(5), PMM1(3), PMM2(1), SORD(2), TPI1(9)	19170829	158	122	158	38	33	55	30	13	27	0	0.0156	1.000	1.000
337	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5(3), CDK5R1(3), DAB1(34), FYN(8), LRP8(6), RELN(104), VLDLR(5)	11327920	163	122	162	50	17	62	41	14	29	0	0.623	1.000	1.000
338	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	15	CDK5(3), CDK5R1(3), CSNK1D(7), DRD1(13), GRM1(48), PLCB1(52), PPP1CA(2), PPP1R1B(1), PPP2CA(1), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2)	11231975	154	121	153	36	20	69	30	11	23	1	0.0301	1.000	1.000
339	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	13	C1QA(7), C1QB(11), C1R(4), C1S(4), C2(10), C3(13), C5(6), C6(29), C8A(18), C9(20), MASP1(13), MASP2(8), MBL2(13)	15898744	156	121	155	56	18	69	24	16	28	1	0.787	1.000	1.000
340	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(5), F2(9), F2R(10), F3(3), F5(40), F7(10), FGA(20), FGB(18), FGG(4), PROC(4), PROS1(30), SERPINC1(5), TFPI(4)	13160754	162	121	160	41	13	81	26	11	31	0	0.197	1.000	1.000
341	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(6), F13A1(29), F2(9), F2R(10), FGA(20), FGB(18), FGG(4), PLAT(12), PLG(32), SERPINB2(14), SERPINE1(14)	10835018	168	121	163	47	14	86	33	9	26	0	0.331	1.000	1.000
342	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(3), CS(2), DLAT(10), DLD(9), DLST(5), FH(13), IDH2(2), IDH3A(1), IDH3B(4), IDH3G(5), MDH1(3), MDH2(3), OGDH(10), PC(9), PDHA1(5), PDHA2(29), PDHX(4), PDK1(6), PDK2(3), PDK3(5), PDK4(2), PDP2(4), SDHA(8), SDHB(1), SDHD(3), SUCLA2(5), SUCLG1(5), SUCLG2(1)	22875222	160	121	159	51	23	63	23	22	29	0	0.499	1.000	1.000
343	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ALDH1A3(4), ALDH3A1(5), ALDH3B1(2), ALDH3B2(4), AOC2(6), AOC3(11), DDC(8), EPX(14), ESCO1(10), ESCO2(4), GOT1(3), GOT2(6), HPD(2), LPO(7), MAOA(5), MAOB(3), MPO(15), NAT6(1), PNPLA3(4), PRDX6(5), TAT(9), TPO(33)	27575749	161	120	160	67	31	53	31	20	26	0	0.947	1.000	1.000
344	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(14), ABCC2(11), ABCG2(14), BCHE(35), CES1(8), CYP3A4(4), CYP3A5(5), UGT1A1(12), UGT1A10(9), UGT1A3(6), UGT1A4(4), UGT1A5(8), UGT1A6(9), UGT1A7(7), UGT1A9(7)	18509913	153	119	152	56	12	69	36	16	20	0	0.788	1.000	1.000
345	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	21	APC(33), AXIN1(7), BTRC(12), CCND1(3), CREBBP(30), CSNK1A1(2), CSNK1D(7), CSNK2A1(5), CTBP1(2), DVL1(5), FZD1(6), GSK3B(4), HDAC1(4), MAP3K7(10), MYC(4), NLK(3), PPARD(6), PPP2CA(1), TLE1(5), WIF1(3), WNT1(6)	22115751	158	119	156	33	28	55	29	14	32	0	0.0274	1.000	1.000
346	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	12	C1QA(7), C1QB(11), C1R(4), C1S(4), C2(10), C3(13), C5(6), C6(29), C8A(18), C8B(20), C9(20), MASP1(13)	15531892	155	118	154	52	17	68	24	19	26	1	0.636	1.000	1.000
347	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSA(2), ARSB(6), ARSD(6), ARSE(5), ASAH1(3), GAL3ST1(7), GALC(9), GBA(7), GLA(9), GLB1(3), LCT(50), NEU1(2), NEU2(7), NEU3(5), NEU4(13), PPAP2A(2), PPAP2B(3), PPAP2C(1), SMPD1(3), SPTLC1(3), SPTLC2(3), UGCG(2)	19347418	151	118	150	44	24	74	28	8	17	0	0.156	1.000	1.000
348	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(6), GALNS(3), GLB1(3), GNS(1), GUSB(5), HEXA(6), HGSNAT(6), HPSE(4), HPSE2(16), HYAL1(3), HYAL2(3), IDS(7), IDUA(1), LCT(50), NAGLU(5), SPAM1(25)	16293964	144	118	143	48	17	67	20	22	18	0	0.524	1.000	1.000
349	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(9), AGPAT2(3), AGPAT3(4), AGPAT4(9), AGPAT6(5), AGPS(6), CHPT1(3), ENPP2(19), ENPP6(8), PAFAH1B1(1), PAFAH1B2(2), PAFAH1B3(2), PAFAH2(3), PLA2G12A(4), PLA2G12B(3), PLA2G1B(2), PLA2G2A(5), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(6), PLA2G4A(21), PLA2G6(3), PLD1(19), PLD2(7), PPAP2A(2), PPAP2B(3), PPAP2C(1)	18600534	156	118	155	38	17	65	29	11	34	0	0.0545	1.000	1.000
350	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	10	CD44(7), ICAM1(2), ITGA4(38), ITGAL(26), ITGAM(24), ITGB1(6), ITGB2(8), SELL(9), SELP(29)	11861905	149	118	147	49	11	75	32	11	20	0	0.669	1.000	1.000
351	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA2(2), ADH1A(8), ADH1B(12), ADH4(4), ADH6(8), ADH7(11), ADHFE1(5), AKR1C4(4), AKR1D1(12), ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH9A1(3), BAAT(9), CEL(8), CYP27A1(5), CYP7A1(8), HADHB(10), SOAT2(2), SRD5A1(4)	18668477	161	117	158	45	12	66	37	19	27	0	0.233	1.000	1.000
352	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	21	AKT1(3), EIF4A1(2), EIF4A2(7), EIF4E(4), EIF4G1(19), EIF4G2(5), EIF4G3(20), GHR(19), IRS1(20), MAPK1(2), MAPK14(4), MAPK3(3), MKNK1(4), PABPC1(5), PDK2(3), PDPK1(3), PIK3R1(4), PRKCA(10), PTEN(11), RPS6KB1(3)	20961304	151	117	149	48	16	61	35	13	26	0	0.677	1.000	1.000
353	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	28	ATG3(5), ATG5(3), ATG7(6), BECN1(1), GABARAPL1(1), IFNA1(2), IFNA10(7), IFNA14(4), IFNA16(8), IFNA17(5), IFNA2(5), IFNA21(3), IFNA4(4), IFNA5(5), IFNA7(6), IFNA8(7), IFNG(7), PIK3C3(14), PIK3R4(22), PRKAA1(6), PRKAA2(8), ULK1(8), ULK2(9), ULK3(2)	16463835	148	117	146	33	11	72	32	13	19	1	0.0957	1.000	1.000
354	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(4), ABAT(12), ADSL(2), ADSS(6), AGXT(8), AGXT2(13), ASL(4), ASNS(8), ASPA(5), CAD(25), DARS(3), DDO(5), GAD1(7), GAD2(27), GOT1(3), GOT2(6), GPT2(5), NARS(4), PC(9)	20822772	156	116	156	48	22	56	27	18	32	1	0.352	1.000	1.000
355	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	23	ACTA1(9), CAPN1(2), CAPN2(5), CAPNS1(1), CAPNS2(2), CXCR3(3), EGF(13), HRAS(2), ITGA1(14), ITGB1(6), MAPK1(2), MAPK3(3), MYL2(8), MYLK(26), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PTK2(6), PXN(1), TLN1(15)	24158179	142	116	141	54	17	56	30	16	22	1	0.890	1.000	1.000
356	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	19	AKT1(3), APAF1(10), ATM(53), BAX(3), BCL2(5), BCL2L1(3), BID(2), CASP3(5), CASP6(3), CASP7(3), CASP9(6), CYCS(2), PRKCA(10), PTK2(6), PXN(1), STAT1(7), TLN1(15)	21388156	137	115	134	41	12	48	24	19	32	2	0.677	1.000	1.000
357	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	21	AKT1(3), BCL2(5), BCR(11), CRKL(4), FOS(3), GRB2(6), HRAS(2), JAK2(16), JUN(3), MAP2K1(10), MAP2K4(8), MAP3K1(7), MAPK3(3), MAPK8(2), MYC(4), PIK3R1(4), RAF1(6), SOS1(17), STAT1(7), STAT5A(3), STAT5B(8)	20782269	132	115	126	34	15	39	34	18	26	0	0.213	1.000	1.000
358	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(9), ADCY1(26), CCNB1(2), CDC25C(8), GNAI1(10), GNAS(29), GNB1(2), GNGT1(6), HRAS(2), MAPK1(2), MAPK3(3), MYT1(24), PIN1(1), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), RPS6KA1(6), SRC(2)	16355330	156	114	153	50	33	60	27	10	24	2	0.397	1.000	1.000
359	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(7), CREBBP(30), DUSP1(1), EP300(11), IKBKB(9), IL1B(1), MAP2K3(13), MAP2K6(5), MAP3K7(10), MAPK14(4), MYD88(1), NFKB1(6), NFKBIA(4), NR3C1(8), RELA(3), TGFBR1(7), TGFBR2(7), TLR2(10), TNF(2)	23832807	139	114	138	43	12	48	29	12	38	0	0.643	1.000	1.000
360	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ALDH1A3(4), ALDH3A1(5), ALDH3B1(2), ALDH3B2(4), AOC2(6), AOC3(11), DDC(8), EPX(14), GOT1(3), GOT2(6), HPD(2), LPO(7), MAOA(5), MAOB(3), MPO(15), PRDX1(4), PRDX2(2), PRDX5(1), PRDX6(5), TAT(9), TPO(33)	17678811	149	114	148	62	30	49	28	20	22	0	0.855	1.000	1.000
361	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(33), ASAH1(3), CAMP(4), CASP3(5), CERK(4), CREB1(2), CREB5(18), CXCL2(1), DAG1(3), EPHB2(10), FOS(3), GNAQ(5), ITPKA(2), ITPKB(7), JUN(3), MAP2K4(8), MAP2K7(7), MAPK1(2), MAPK10(6), MAPK8(2), MAPK8IP1(4), MAPK8IP2(2), MAPK8IP3(7), MAPK9(8)	22589372	149	114	148	33	21	49	30	9	40	0	0.0495	1.000	1.000
362	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(10), BCL2(5), BID(2), BIRC2(2), BIRC3(4), CASP10(7), CASP3(5), CASP6(3), CASP7(3), CASP8(6), CASP9(6), CFLAR(2), CHUK(7), CYCS(2), DFFA(3), DFFB(4), FADD(2), GAS2(10), LMNA(2), NFKB1(6), NFKBIA(4), RELA(3), RIPK1(11), SPTAN1(21), TNFRSF10B(3), TNFRSF25(2), TNFSF10(3), TNFSF12(1), TRADD(2), TRAF2(5)	26779656	146	113	146	53	8	51	38	16	33	0	0.935	1.000	1.000
363	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(12), BAIAP2(3), CASP1(8), CASP3(5), CASP7(3), CASP8(6), GAPDH(5), INSR(10), ITCH(8), MAGI1(21), MAGI2(33), RERE(12), WWP1(13), WWP2(7)	19234129	146	113	145	42	16	63	21	14	32	0	0.436	1.000	1.000
364	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	15	BCL2(5), CREBBP(30), EP300(11), FYN(8), IL2RG(5), IL7(2), IL7R(21), JAK1(11), JAK3(10), LCK(9), NMI(2), PIK3R1(4), PTK2B(14), STAT5A(3), STAT5B(8)	20682222	143	113	143	47	22	45	29	16	31	0	0.608	1.000	1.000
365	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(9), ACTN1(7), ACTN2(43), CAPN1(2), CAPNS1(1), CAPNS2(2), ITGA1(14), ITGB1(6), ITGB3(13), PTK2(6), PXN(1), SPTAN1(21), SRC(2), TLN1(15)	22874847	142	113	141	56	15	52	38	19	18	0	0.906	1.000	1.000
366	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	12	ACTN1(7), ACTN2(43), BCAR1(3), CSK(2), CTNNA1(9), CTNNA2(65), PTK2(6), PXN(1), SRC(2), VCL(8)	13941488	146	112	145	51	19	58	30	17	22	0	0.571	1.000	1.000
367	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(15), ACE2(9), AGT(4), AGTR1(9), AGTR2(6), ANPEP(10), CMA1(8), CPA3(16), CTSA(4), CTSG(12), ENPEP(18), LNPEP(5), MAS1(5), MME(20), NLN(7), REN(6), THOP1(8)	16967000	162	112	161	62	21	71	28	18	23	1	0.765	1.000	1.000
368	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(7), IFNA1(2), IFNB1(7), IKBKB(9), IL1A(4), IL1B(1), IL1R1(2), IL1RAP(4), IL1RN(3), IL6(2), IRAK1(6), IRAK2(6), IRAK3(6), JUN(3), MAP2K3(13), MAP2K6(5), MAP3K1(7), MAP3K7(10), MAPK14(4), MAPK8(2), MYD88(1), NFKB1(6), NFKBIA(4), RELA(3), TGFB1(3), TGFB2(10), TNF(2), TOLLIP(2), TRAF6(6)	23848641	140	112	139	51	6	50	30	17	37	0	0.928	1.000	1.000
369	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	20	CSNK2A1(5), ELK1(3), FOS(3), GRB2(6), HRAS(2), IL6(2), IL6R(8), IL6ST(3), JAK1(11), JAK2(16), JAK3(10), JUN(3), MAP2K1(10), MAPK3(3), PTPN11(9), RAF1(6), SHC1(6), SOS1(17), SRF(1), STAT3(11)	18997736	135	112	130	35	16	37	32	24	26	0	0.271	1.000	1.000
370	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	28	ATF1(1), CREB1(2), CREB5(18), DUSP4(2), DUSP6(4), DUSP9(6), EEF2K(7), EIF4E(4), GRB2(6), MAP2K1(10), MAP2K2(1), MAP3K8(4), MAPK1(2), MAPK3(3), MKNK1(4), MKNK2(2), MOS(9), NFKB1(6), RAP1A(1), RPS6KA1(6), RPS6KA2(8), RPS6KA3(6), SHC1(6), SOS1(17), SOS2(13), TRAF3(4)	22404326	152	112	149	41	20	60	33	14	25	0	0.229	1.000	1.000
371	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(33), CDH1(6), CREBBP(30), EP300(11), MAP2K1(10), MAP3K7(10), MAPK3(3), SKIL(11), TGFB1(3), TGFB2(10), TGFBR1(7), TGFBR2(7)	20740652	141	112	138	25	14	50	28	14	35	0	0.0268	1.000	1.000
372	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(3), CR1(34), CR2(20), FCGR2B(7), HLA-DRA(3), HLA-DRB1(5), ICAM1(2), ITGAL(26), ITGB2(8), PTPRC(41)	12281228	149	111	144	48	11	63	28	10	37	0	0.776	1.000	1.000
373	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOA(4), ALDOB(8), ALDOC(2), DERA(4), FBP1(2), FBP2(2), G6PD(4), GPI(8), H6PD(5), PFKL(9), PFKM(7), PFKP(5), PGD(2), PGLS(1), PGM1(3), PGM3(3), PRPS1(3), PRPS1L1(3), PRPS2(4), RBKS(1), RPE(3), RPIA(8), TALDO1(1), TKT(3), TKTL1(14), TKTL2(26)	19391436	135	111	135	36	16	44	31	17	27	0	0.149	1.000	1.000
374	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(6), FUCA1(2), FUCA2(3), GLB1(3), HEXA(6), LCT(50), MAN2B1(5), MAN2B2(7), MAN2C1(7), MANBA(11), NEU1(2), NEU2(7), NEU3(5), NEU4(13)	16216807	127	111	126	43	21	60	22	9	15	0	0.461	1.000	1.000
375	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(10), ALOX15(5), ALOX5(10), CYP1A2(3), CYP2C18(7), CYP2C19(13), CYP2C8(2), CYP2C9(8), CYP2E1(7), CYP2J2(1), CYP3A4(4), CYP3A43(3), CYP3A5(5), CYP3A7(7), HSD3B7(7), PLA2G12A(4), PLA2G12B(3), PLA2G1B(2), PLA2G2A(5), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(6), PLA2G4A(21), PLA2G6(3), RDH11(4), RDH12(3), RDH13(1), RDH14(2)	19242354	152	111	151	62	17	66	37	15	17	0	0.905	1.000	1.000
376	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(1), B4GALNT1(9), GLB1(3), HEXA(6), LCT(50), SLC33A1(4), ST3GAL1(4), ST3GAL2(4), ST3GAL5(3), ST6GALNAC3(15), ST6GALNAC4(1), ST6GALNAC5(11), ST6GALNAC6(2), ST8SIA1(6), ST8SIA5(12)	13265083	131	111	130	49	24	47	27	12	21	0	0.684	1.000	1.000
377	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(4), CARS(4), DARS(3), EPRS(27), FARS2(5), GARS(3), HARS(5), IARS(9), KARS(8), LARS(14), LARS2(2), MARS(5), MARS2(13), NARS(4), QARS(6), RARS(6), SARS(5), TARS(14), WARS(6), WARS2(7), YARS(3)	25898121	153	110	153	38	12	59	35	18	29	0	0.232	1.000	1.000
378	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CCNH(3), CDK7(3), ERCC3(5), GTF2A2(1), GTF2B(1), GTF2E1(8), GTF2E2(2), GTF2H1(4), GTF2H4(1), ILK(1), MNAT1(2), POLR1A(13), POLR1B(11), POLR2A(11), POLR2B(10), POLR2C(4), POLR2E(2), POLR2F(1), POLR2G(1), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(2), POLR3B(20), POLR3D(3), POLR3E(6), POLR3H(1), POLR3K(2), TAF5(5), TAF6(3), TAF7(3), TAF9(3), TBP(1)	28239498	137	108	137	47	22	40	39	14	21	1	0.865	1.000	1.000
379	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(8), DYRK1B(5), GLI2(28), GLI3(39), GSK3B(4), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), SHH(2), SMO(17), SUFU(2)	13336116	129	108	127	38	34	45	25	7	17	1	0.222	1.000	1.000
380	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	19	CSNK2A1(5), ELK1(3), FOS(3), GRB2(6), HRAS(2), IGF1(4), IGF1R(8), IRS1(20), JUN(3), MAP2K1(10), MAPK3(3), MAPK8(2), PIK3R1(4), PTPN11(9), RAF1(6), RASA1(11), SHC1(6), SOS1(17), SRF(1)	18229048	123	107	118	37	17	40	23	15	28	0	0.511	1.000	1.000
381	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	AANAT(1), ACHE(4), CHAT(22), COMT(1), DBH(12), DDC(8), GAD1(7), GAD2(27), HDC(16), MAOA(5), PAH(11), PNMT(1), SLC18A3(19), TH(7), TPH1(8)	11438375	149	106	148	53	23	60	25	10	31	0	0.592	1.000	1.000
382	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(5), ELK1(3), FOS(3), GRB2(6), HRAS(2), IL2(7), IL2RA(6), IL2RB(7), IL2RG(5), JAK1(11), JAK3(10), JUN(3), LCK(9), MAP2K1(10), MAPK3(3), MAPK8(2), RAF1(6), SHC1(6), SOS1(17), STAT5A(3), STAT5B(8), SYK(5)	18686649	137	106	132	38	16	46	29	20	26	0	0.283	1.000	1.000
383	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(6), GALNT10(6), GALNT2(11), GALNT3(12), GALNT4(4), GALNT6(5), GALNT7(9), GALNT8(19), GCNT1(8), ST3GAL1(4), ST3GAL2(4), ST3GAL4(4), WBSCR17(33)	11655898	125	106	124	62	15	50	31	15	14	0	0.998	1.000	1.000
384	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	11	CBL(10), CSF1R(18), EGF(13), GRB2(6), MET(22), PDGFRA(41), PRKCA(10), SH3GLB2(1), SH3KBP1(7), SRC(2)	13545663	130	105	126	42	15	44	26	14	30	1	0.702	1.000	1.000
385	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(22), BST1(3), CD38(4), ENPP1(14), ENPP3(19), NADK(3), NADSYN1(2), NMNAT1(3), NMNAT2(8), NMNAT3(1), NNMT(7), NNT(11), NT5C1A(12), NT5C1B(11), NT5C2(3), NT5E(5), NT5M(3), NUDT12(7), QPRT(2)	17307368	140	105	138	41	15	50	21	21	33	0	0.457	1.000	1.000
386	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	20	CSNK2A1(5), ELK1(3), FOS(3), GRB2(6), HRAS(2), INSR(10), IRS1(20), JUN(3), MAP2K1(10), MAPK3(3), MAPK8(2), PIK3R1(4), PTPN11(9), RAF1(6), RASA1(11), SHC1(6), SLC2A4(4), SOS1(17), SRF(1)	18750941	125	105	120	42	19	36	26	18	26	0	0.707	1.000	1.000
387	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCL4(2), CCR1(3), CCR2(6), CCR3(4), CCR4(3), CCR5(4), CD28(4), CD4(8), CXCR3(3), CXCR4(6), IFNG(7), IFNGR1(7), IFNGR2(4), IL12A(2), IL12B(3), IL12RB1(5), IL12RB2(15), IL18R1(12), IL2(7), IL4(1), IL4R(10), IL5(2), TGFB1(3), TGFB2(10)	16147480	131	105	131	33	14	53	21	13	29	1	0.0856	1.000	1.000
388	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(17), APOA1(3), APOA4(12), APOC1(2), APOC2(2), APOC3(2), APOE(1), CETP(8), CYP7A1(8), DGAT1(1), HMGCR(5), LCAT(6), LDLR(9), LIPC(9), LPL(8), LRP1(36), SCARB1(4), SOAT1(8)	21987629	141	105	137	53	21	50	25	19	25	1	0.832	1.000	1.000
389	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	28	AKT1(3), CABIN1(10), CALM1(3), CALM2(1), CAMK1(1), CAMK1G(2), HDAC5(5), IGF1(4), IGF1R(8), INSR(10), MAP2K6(5), MAPK14(4), MAPK7(7), MEF2A(2), MEF2B(2), MEF2C(6), MEF2D(4), MYOD1(7), NFATC1(9), NFATC2(15), PIK3R1(4), PPP3CB(3), PPP3CC(3), SYT1(6), YWHAH(1)	25110486	125	103	124	49	18	49	18	10	30	0	0.731	1.000	1.000
390	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(7), DCXR(1), GUSB(5), RPE(3), UCHL1(4), UCHL3(1), UGDH(6), UGT1A1(12), UGT1A10(9), UGT1A3(6), UGT1A4(4), UGT1A5(8), UGT1A6(9), UGT1A7(7), UGT1A9(7), UGT2B15(14), UGT2B4(28)	14237894	131	103	130	40	6	59	35	13	18	0	0.514	1.000	1.000
391	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	31	DUSP1(1), GORASP1(2), MAP2K4(8), MAP2K7(7), MAPK1(2), MAPK10(6), MAPK12(2), MAPK13(1), MAPK14(4), MAPK3(3), MAPK8(2), MAPK8IP1(4), MAPK8IP2(2), MAPK8IP3(7), MAPK9(8), MAPKAPK5(5), NFKB1(6), NFKB2(5), NFKBIA(4), NFKBIB(3), NFKBIE(2), NFKBIL1(1), PIK3CD(4), PIK3R1(4), SYT1(6), TRAF2(5), TRAF3(4), TRAF5(5), TRAF6(6)	24607286	119	103	119	49	19	35	21	13	31	0	0.890	1.000	1.000
392	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(1), CSF1R(18), DDX20(4), E2F1(3), E2F4(5), ETS1(8), ETS2(6), ETV3(2), FOS(3), HDAC2(8), HDAC5(5), HRAS(2), JUN(3), NCOR2(30), RBL1(7), RBL2(5), SIN3A(12), SIN3B(2)	20506999	124	102	124	43	15	35	33	17	24	0	0.770	1.000	1.000
393	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ALDH1A1(8), ALDH1A2(8), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH3B1(2), ALDH3B2(4), ALDH9A1(3), AOC2(6), AOC3(11), ASPA(5), CNDP1(10), DDC(8), HAL(5), HARS(5), HDC(16), MAOA(5), MAOB(3), PRPS1(3), PRPS2(4)	19703306	136	102	136	40	25	46	24	18	23	0	0.194	1.000	1.000
394	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	20	AKT1(3), EIF4A1(2), EIF4A2(7), EIF4B(7), EIF4E(4), EIF4G1(19), EIF4G2(5), EIF4G3(20), MKNK1(4), PDK2(3), PDPK1(3), PIK3R1(4), PPP2CA(1), PTEN(11), RPS6(3), RPS6KB1(3), TSC1(10), TSC2(13)	20287773	122	102	120	37	12	39	32	11	28	0	0.612	1.000	1.000
395	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(5), GTF2A1(3), GTF2B(1), GTF2E1(8), GTF2F1(4), HDAC3(3), NCOA1(18), NCOA2(22), NCOA3(14), NCOR2(30), POLR2A(11), RARA(7), RXRA(1), TBP(1)	19823020	128	102	128	39	17	43	33	19	16	0	0.510	1.000	1.000
396	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(3), BCAT2(2), COASY(6), DPYD(24), DPYS(22), ENPP1(14), ENPP3(19), ILVBL(3), PANK1(4), PANK2(5), PANK3(5), PANK4(5), PPCDC(2), PPCS(1), UPB1(2), VNN1(10)	13820415	127	101	124	34	14	59	18	15	20	1	0.220	1.000	1.000
397	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(6), FUCA1(2), FUCA2(3), GLB1(3), HEXA(6), LCT(50), MAN2C1(7), MANBA(11), NEU1(2), NEU2(7), NEU3(5), NEU4(13)	13180834	115	101	114	36	18	57	20	7	13	0	0.333	1.000	1.000
398	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(2), ALDH18A1(3), ARG1(2), ASL(4), CKB(1), CKM(4), CKMT1A(1), CKMT1B(1), CKMT2(2), CPS1(71), GATM(8), GLUD1(4), NAGS(1), OAT(3), ODC1(1), OTC(10), PYCR1(1), SMS(3)	13907447	122	101	121	44	12	47	22	18	22	1	0.811	1.000	1.000
399	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	26	CALM1(3), CALM2(1), CHUK(7), EGR2(4), EGR3(1), GNAQ(5), MAP3K1(7), MYC(4), NFATC1(9), NFATC2(15), NFKB1(6), NFKBIA(4), PLCG1(7), PPP3CB(3), PPP3CC(3), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), RELA(3), SYT1(6), VIP(6), VIPR2(3)	21571023	121	101	121	41	17	49	20	12	22	1	0.610	1.000	1.000
400	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	10	C1QA(7), C1QB(11), C1R(4), C1S(4), C2(10), C3(13), C5(6), C6(29), C8A(18), C9(20)	12861381	122	100	122	45	15	49	21	15	21	1	0.839	1.000	1.000
401	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	22	BCAR1(3), CRK(1), CXCL12(3), CXCR4(6), GNAI1(10), GNAQ(5), GNB1(2), GNGT1(6), HRAS(2), MAP2K1(10), MAPK1(2), MAPK3(3), NFKB1(6), PIK3C2G(19), PIK3R1(4), PLCG1(7), PRKCA(10), PTK2(6), PTK2B(14), PXN(1), RAF1(6), RELA(3)	20314865	129	100	126	38	18	53	23	11	24	0	0.305	1.000	1.000
402	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(1), CARM1(4), CBS(1), CTH(2), GGT1(1), LCMT1(5), LCMT2(7), MARS(5), MARS2(13), MAT1A(7), MAT2B(3), METTL2B(5), METTL6(1), PAPSS1(5), PAPSS2(10), PRMT2(2), PRMT3(8), PRMT5(7), PRMT6(7), PRMT7(4), PRMT8(13), SCLY(4), SEPHS1(4), SEPHS2(2), WBSCR22(3)	20010499	124	100	122	50	22	40	27	13	22	0	0.884	1.000	1.000
403	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(45), ABCB11(28), ABCB4(19), ABCC1(14), ABCC3(13), GSTP1(2)	11611517	121	99	120	35	11	48	27	11	24	0	0.309	1.000	1.000
404	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	36	ANPEP(10), G6PD(4), GCLC(13), GGT1(1), GPX3(2), GPX5(7), GPX6(7), GPX7(4), GSR(5), GSS(4), GSTA1(7), GSTA2(7), GSTA3(2), GSTA4(2), GSTA5(6), GSTK1(1), GSTM1(1), GSTM2(4), GSTM3(2), GSTM4(1), GSTM5(3), GSTO2(3), GSTP1(2), GSTT1(1), GSTZ1(2), IDH1(6), IDH2(2), MGST1(1), MGST2(2), MGST3(2), OPLAH(10), TXNDC12(2)	17465013	126	98	127	21	15	49	19	10	33	0	0.000431	1.000	1.000
405	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	ATF1(1), CASP2(13), CHUK(7), CRADD(3), IKBKB(9), JUN(3), LTA(3), MAP2K3(13), MAP2K4(8), MAP2K6(5), MAP3K1(7), MAP4K2(4), MAPK14(4), MAPK8(2), NFKB1(6), NFKBIA(4), RELA(3), RIPK1(11), TANK(3), TNF(2), TRADD(2), TRAF2(5)	19246618	118	98	118	41	9	43	26	10	30	0	0.777	1.000	1.000
406	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(1), AMD1(2), BHMT(7), CBS(1), CTH(2), DNMT1(8), DNMT3A(25), DNMT3B(10), MARS(5), MARS2(13), MAT1A(7), MAT2B(3), MTAP(2), MTFMT(1), MTR(22), SRM(2), TAT(9)	16605481	120	97	120	40	18	44	22	11	25	0	0.623	1.000	1.000
407	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	21	ADCY1(26), AKT1(3), BAX(3), BCL2(5), BCL2L1(3), CSF2RB(14), IGF1(4), IGF1R(8), IL3(4), IL3RA(8), KIT(12), KITLG(6), PIK3R1(4), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), YWHAH(1)	15840925	125	96	124	51	14	52	29	9	19	2	0.870	1.000	1.000
408	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(5), ACO2(3), CS(2), DLD(9), DLST(5), FH(13), IDH1(6), IDH2(2), IDH3A(1), IDH3B(4), IDH3G(5), MDH1(3), MDH2(3), PC(9), PCK1(21), SDHA(8), SDHB(1), SUCLA2(5), SUCLG1(5), SUCLG2(1)	16611796	111	96	110	46	18	38	12	18	25	0	0.898	1.000	1.000
409	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	16	B3GAT1(5), B3GAT2(10), CHPF(10), CHST11(2), CHST12(6), CHST13(3), CHST14(2), CHST3(1), CHST7(2), CHSY1(5), DSE(19), UST(5), XYLT1(44), XYLT2(3)	11111541	117	96	115	48	29	31	28	12	17	0	0.774	1.000	1.000
410	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(26), CREM(3), FHL5(15), FSHB(4), FSHR(37), GNAS(29), XPO1(12)	7620498	126	95	122	42	24	54	23	10	14	1	0.784	1.000	1.000
411	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(5), ELK1(3), EPO(6), EPOR(2), FOS(3), GRB2(6), HRAS(2), JAK2(16), JUN(3), MAP2K1(10), MAPK3(3), MAPK8(2), PLCG1(7), PTPN6(6), RAF1(6), SHC1(6), SOS1(17), STAT5A(3), STAT5B(8)	17270267	114	95	109	24	19	34	26	15	20	0	0.0459	1.000	1.000
412	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(4), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH7A1(3), ALDH9A1(3), CYP2C19(13), CYP2C9(8), DHRS2(6), DHRS3(2), DHRS7(3), DHRSX(3), ECHS1(4), EHHADH(13), ESCO1(10), ESCO2(4), HADHA(3), NAT6(1), PNPLA3(4), YOD1(1)	24862284	115	95	114	35	13	42	28	13	19	0	0.567	1.000	1.000
413	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(3), COASY(6), DPYD(24), DPYS(22), ENPP1(14), ENPP3(19), PANK1(4), PANK2(5), PANK3(5), PANK4(5), PPCS(1), UPB1(2)	11120123	110	93	107	31	10	51	16	13	19	1	0.410	1.000	1.000
414	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(14), LPO(7), MPO(15), PRDX1(4), PRDX2(2), PRDX5(1), PRDX6(5), TPO(33), TYR(29)	7742906	110	93	109	43	18	40	24	12	16	0	0.774	1.000	1.000
415	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	17	CALM1(3), CALM2(1), CDKN1A(2), GNAQ(5), MARCKS(2), NFATC1(9), NFATC2(15), NFATC3(15), NFATC4(11), PLCG1(7), PPP3CB(3), PPP3CC(3), PRKCA(10), SP1(6), SP3(6), SYT1(6)	15924463	104	92	104	38	17	45	18	6	18	0	0.684	1.000	1.000
416	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(14), FOS(3), GRB2(6), HRAS(2), IL3(4), IL3RA(8), JAK2(16), MAP2K1(10), MAPK3(3), PTPN6(6), RAF1(6), SHC1(6), SOS1(17), STAT5A(3), STAT5B(8)	14173710	112	92	107	27	17	38	28	15	14	0	0.103	1.000	1.000
417	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	11	ADAM17(8), APC(33), AXIN1(7), BTRC(12), DLL1(5), DVL1(5), FZD1(6), GSK3B(4), NOTCH1(26), PSEN1(6), WNT1(6)	15330327	118	92	117	26	28	35	19	11	25	0	0.0505	1.000	1.000
418	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(3), AP2A1(4), AP2M1(5), ARF1(1), BTK(25), EEA1(5), GSK3A(1), GSK3B(4), LYN(6), PDPK1(3), PFKL(9), PFKM(7), PFKP(5), PLCG1(7), PRKCE(5), PRKCZ(4), RAB5A(2), RPS6KB1(3), VAV2(8)	19805791	107	91	106	27	12	31	28	12	23	1	0.225	1.000	1.000
419	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BIRC2(2), BIRC3(4), CASP3(5), CASP8(6), CFLAR(2), FADD(2), JUN(3), MAP2K4(8), MAP3K3(10), MAP3K7(10), NFKB1(6), NFKB2(5), NFKBIA(4), NFKBIB(3), NFKBIE(2), NFKBIL1(1), NR2C2(2), RALBP1(3), RIPK1(11), TNF(2), TNFAIP3(6), TNFRSF1B(2), TRADD(2), TRAF2(5)	21702517	106	91	105	33	9	40	24	7	26	0	0.621	1.000	1.000
420	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(6), GPLD1(10), PGAP1(8), PIGA(6), PIGB(5), PIGC(1), PIGG(13), PIGK(3), PIGL(4), PIGM(2), PIGN(10), PIGO(11), PIGP(2), PIGQ(6), PIGS(4), PIGT(7), PIGU(1), PIGV(4), PIGW(2), PIGX(4), PIGZ(3)	19033646	112	89	111	49	13	38	27	15	19	0	0.961	1.000	1.000
421	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	18	AMPH(24), AP2A1(4), AP2M1(5), BIN1(4), CALM1(3), CALM2(1), DNM1(11), EPN1(11), EPS15(7), PICALM(6), PPP3CB(3), PPP3CC(3), SYNJ1(14), SYNJ2(9), SYT1(6)	16457473	111	89	110	39	13	41	24	9	24	0	0.863	1.000	1.000
422	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(26), ADRB2(4), GNAS(29), PLCE1(28), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), RAP2B(2)	11785893	113	89	109	38	27	44	17	8	14	3	0.570	1.000	1.000
423	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	12	AKT1(3), BCL2(5), IGF1R(8), MYC(4), POLR2A(11), PPP2CA(1), PRKCA(10), TEP1(39), TERF1(4), TERT(7), TNKS(11), XRCC5(9)	18483160	112	89	111	42	17	44	20	8	23	0	0.665	1.000	1.000
424	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(4), AKR1D1(12), CYP11A1(5), CYP11B1(27), CYP11B2(24), CYP17A1(6), CYP21A2(2), HSD11B1(9), HSD3B1(6), HSD3B2(15)	7379109	110	88	109	40	12	42	26	13	16	1	0.596	1.000	1.000
425	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(26), GNAS(29), GNB1(2), GNGT1(6), PPP2CA(1), PRKAA1(6), PRKAA2(8), PRKAB1(3), PRKACB(9), PRKACG(4), PRKAG1(1), PRKAG2(5), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2)	12237886	111	88	108	38	26	39	24	7	13	2	0.751	1.000	1.000
426	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(4), AKR1D1(12), CYP11A1(5), CYP11B1(27), CYP11B2(24), CYP17A1(6), CYP21A2(2), HSD11B1(9), HSD3B1(6), HSD3B2(15)	7379109	110	88	109	40	12	42	26	13	16	1	0.596	1.000	1.000
427	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP1(4), ACP2(4), ACP5(4), ACP6(3), ACPP(8), ACPT(7), ALPI(9), ALPL(3), ALPP(13), ALPPL2(4), CMBL(1), CYP3A4(4), CYP3A43(3), CYP3A5(5), CYP3A7(7), DHRS2(6), DHRS3(2), DHRS7(3), DHRSX(3), PON1(3), PON2(2), PON3(5)	14444794	103	88	103	43	5	40	22	15	21	0	0.919	1.000	1.000
428	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(13), POLR1B(11), POLR1D(2), POLR2A(11), POLR2B(10), POLR2C(4), POLR2D(3), POLR2E(2), POLR2F(1), POLR2G(1), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(2), POLR3A(17), POLR3B(20), POLR3G(2), POLR3H(1), POLR3K(2), ZNRD1(1)	18917469	107	87	107	34	16	35	31	9	16	0	0.696	1.000	1.000
429	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(4), ALG5(1), B4GALT1(1), B4GALT2(4), B4GALT3(2), B4GALT5(6), DDOST(1), DPAGT1(5), DPM1(5), FUT8(7), MAN1A1(3), MAN1B1(4), MGAT1(7), MGAT2(5), MGAT3(15), MGAT4A(3), MGAT4B(7), MGAT5(13), RPN1(3), RPN2(4), ST6GAL1(4)	15889813	104	87	104	30	19	44	14	11	16	0	0.214	1.000	1.000
430	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(6), CD28(4), CD3D(2), CD3E(2), CD4(8), ICAM1(2), ITGAL(26), ITGB2(8), PTPRC(41), THY1(6)	9079402	105	87	105	36	11	39	24	5	26	0	0.679	1.000	1.000
431	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(14), AMT(1), ATIC(7), DHFR(2), FTCD(8), GART(9), MTFMT(1), MTHFD1(6), MTHFD1L(12), MTHFD2(2), MTHFR(7), MTHFS(1), MTR(22), SHMT1(2), SHMT2(2), TYMS(3)	15191954	99	86	98	25	14	40	12	7	26	0	0.150	1.000	1.000
432	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(6), IL22(4), IL22RA1(7), IL22RA2(6), JAK1(11), JAK2(16), JAK3(10), STAT1(7), STAT3(11), STAT5A(3), STAT5B(8), TYK2(5)	14605481	94	86	94	28	8	24	21	18	23	0	0.584	1.000	1.000
433	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	CISH(1), IL6(2), IL6R(8), JAK1(11), JAK2(16), JAK3(10), PIAS3(7), PTPRU(19), REG1A(20), SRC(2), STAT3(11)	12181194	107	86	105	32	12	36	21	14	24	0	0.368	1.000	1.000
434	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(10), CHUK(7), IFNG(7), IKBKB(9), IL2(7), IL4(1), JUN(3), MAP3K1(7), MAP3K5(14), MAP4K5(2), MAPK14(4), MAPK8(2), NFKB1(6), NFKBIA(4), RELA(3), TNFRSF9(7), TNFSF9(3), TRAF2(5)	15554068	101	85	101	29	7	32	18	10	33	1	0.652	1.000	1.000
435	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(32), MAP2(49), PPP1CA(2), PPP2CA(1), PRKACB(9), PRKACG(4), PRKAG1(1), PRKAR2A(3), PRKAR2B(2), PRKCE(5)	14641764	108	85	107	27	9	42	27	14	14	2	0.525	1.000	1.000
436	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(10), GCK(6), GFPT1(8), GNE(2), GNPDA1(2), GNPDA2(2), HEXA(6), HK1(12), HK2(11), HK3(22), PGM3(3), RENBP(7), UAP1(7)	13601954	98	85	98	32	23	36	13	11	15	0	0.469	1.000	1.000
437	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(10), ARHGDIB(2), BIRC2(2), BIRC3(4), CASP1(8), CASP10(7), CASP2(13), CASP3(5), CASP4(6), CASP6(3), CASP7(3), CASP8(6), CASP9(6), CYCS(2), DFFA(3), DFFB(4), GZMB(6), LMNA(2), LMNB1(5), LMNB2(5), PRF1(8)	15507295	110	85	109	32	4	45	24	13	24	0	0.585	1.000	1.000
438	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	CNR1(15), CNR2(3), DNMT1(8), MTNR1A(15), MTNR1B(13), PTAFR(5), PTGDR(8), PTGER2(4), PTGER4(7), PTGFR(12), PTGIR(6), TBXA2R(1)	8843339	97	85	96	38	20	31	19	13	13	1	0.599	1.000	1.000
439	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOA(4), ALDOB(8), ALDOC(2), FBP1(2), FBP2(2), GOT1(3), GOT2(6), GPT2(5), MDH1(3), MDH2(3), ME1(3), ME2(9), ME3(8), PGK1(4), PKLR(16), RPE(3), RPIA(8), TKT(3), TPI1(9)	14454299	101	84	100	20	14	32	21	14	20	0	0.0258	1.000	1.000
440	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(1), BHMT(7), CBS(1), CTH(2), DNMT1(8), DNMT3A(25), DNMT3B(10), MARS(5), MARS2(13), MAT1A(7), MAT2B(3), MTR(22)	13939418	104	84	104	33	13	37	20	11	23	0	0.506	1.000	1.000
441	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	17	CSNK2A1(5), ELK1(3), FOS(3), GRB2(6), HRAS(2), JUN(3), KLK2(10), MAP2K1(10), MAPK3(3), MAPK8(2), NGFR(5), PIK3R1(4), PLCG1(7), RAF1(6), SHC1(6), SOS1(17)	13628895	92	84	87	25	12	32	21	11	16	0	0.331	1.000	1.000
442	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(9), ACTR2(4), ACTR3(2), ARPC1A(3), ARPC1B(4), ARPC2(3), ARPC3(2), NCK1(5), NCKAP1(11), NTRK1(14), PIR(4), PSMA7(5), WASF1(10), WASF2(3), WASF3(13), WASL(7)	12318169	99	83	97	35	13	30	22	10	23	1	0.848	1.000	1.000
443	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	15	ADAM12(18), AGT(4), AGTR2(6), EDN1(1), EDNRA(3), EDNRB(16), EGF(13), FOS(3), HRAS(2), JUN(3), MYC(4), NFKB1(6), PLCG1(7), PRKCA(10), RELA(3)	14455764	99	83	98	33	14	34	22	12	17	0	0.677	1.000	1.000
444	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BAX(3), BCL2(5), CASP8(6), CYCS(2), FADD(2), MAP2K1(10), MAP2K4(8), MAP3K1(7), MAPK1(2), MAPK3(3), MAPK8(2), NFKB1(6), NSMAF(10), RAF1(6), RELA(3), RIPK1(11), SMPD1(3), TRADD(2), TRAF2(5)	16473660	96	83	93	32	11	33	27	11	14	0	0.654	1.000	1.000
445	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CCR5(4), CD3D(2), CD3E(2), CXCR3(3), ETV5(6), IFNG(7), IL12A(2), IL12B(3), IL12RB1(5), IL12RB2(15), IL18R1(12), JAK2(16), JUN(3), MAP2K6(5), MAPK14(4), MAPK8(2), STAT4(11), TYK2(5)	14944366	107	83	107	25	10	35	21	12	28	1	0.163	1.000	1.000
446	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	17	CABIN1(10), CALM1(3), CALM2(1), CAPN2(5), CAPNS1(1), CAPNS2(2), EP300(11), HDAC1(4), HDAC2(8), MEF2D(4), NFATC1(9), NFATC2(15), PPP3CB(3), PPP3CC(3), PRKCA(10), SYT1(6)	18692549	95	83	95	40	19	35	12	7	22	0	0.879	1.000	1.000
447	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(2), ATP6V0C(4), CAT(3), EPX(14), LPO(7), MPO(15), PRDX1(4), PRDX2(2), PRDX5(1), PRDX6(5), SHMT1(2), SHMT2(2), TPO(33)	9442451	94	83	92	38	18	32	18	12	14	0	0.781	1.000	1.000
448	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(14), AMT(1), ATIC(7), ATP6V0C(4), DHFR(2), GART(9), MTHFD1(6), MTHFD1L(12), MTHFD2(2), MTHFR(7), MTHFS(1), MTR(22), SHMT1(2), SHMT2(2), TYMS(3)	14411684	94	83	92	22	14	36	11	8	25	0	0.0868	1.000	1.000
449	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	16	DNAJA3(2), IFNG(7), IFNGR1(7), IFNGR2(4), IKBKB(9), JAK2(16), LIN7A(7), NFKB1(6), NFKBIA(4), RELA(3), TNF(2), TNFRSF1B(2), USH1C(13), WT1(16)	12486516	98	83	97	32	12	34	19	7	25	1	0.610	1.000	1.000
450	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(4), POLD1(7), POLD2(3), POLE(31), POLG(12), POLL(7), POLQ(36)	13406889	100	82	99	30	14	39	25	10	12	0	0.487	1.000	1.000
451	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	8	CD44(7), ICAM1(2), ITGA4(38), ITGAL(26), ITGB1(6), ITGB2(8), SELL(9)	8750494	96	82	94	29	6	48	20	8	14	0	0.600	1.000	1.000
452	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(22), CD38(4), ENPP1(14), ENPP3(19), NADSYN1(2), NMNAT1(3), NMNAT2(8), NNMT(7), NNT(11), NT5E(5), NT5M(3), QPRT(2)	11710641	100	82	98	32	11	39	11	18	21	0	0.605	1.000	1.000
453	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(6), CD28(4), CD3D(2), CD3E(2), CD8A(4), ICAM1(2), ITGAL(26), ITGB2(8), PTPRC(41), THY1(6)	8651043	101	82	101	38	12	35	25	4	25	0	0.828	1.000	1.000
454	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD28(4), CD86(11), HLA-DRA(3), HLA-DRB1(5), IFNG(7), IFNGR1(7), IFNGR2(4), IL12A(2), IL12B(3), IL12RB1(5), IL12RB2(15), IL18R1(12), IL2(7), IL2RA(6), IL4(1), IL4R(10)	10203446	102	82	98	30	10	38	15	7	31	1	0.557	1.000	1.000
455	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(26), ADRB2(4), CFTR(11), GNAS(29), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), SLC9A3R1(1)	10408581	95	81	92	33	24	37	15	6	10	3	0.691	1.000	1.000
456	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	18	HLA-A(8), ITGB1(6), KLRC1(5), KLRC2(2), KLRC3(5), KLRC4(2), KLRD1(2), LAT(4), MAP2K1(10), MAPK3(3), PAK1(9), PIK3R1(4), PTK2B(14), PTPN6(6), SYK(5), VAV1(8)	13008052	93	81	89	26	21	30	10	9	23	0	0.251	1.000	1.000
457	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(30), EP300(11), LPL(8), NCOA1(18), NCOA2(22), PPARG(8), RXRA(1)	14903897	98	81	98	19	14	34	21	11	18	0	0.0377	1.000	1.000
458	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(12), KHK(3), LCT(50), MPI(4), PGM1(3), PYGL(6), PYGM(9), TPI1(9), TREH(1)	10753455	97	80	96	27	15	44	23	5	10	0	0.133	1.000	1.000
459	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	65	MRPL13(3), MRPS7(3), RPL10A(2), RPL11(2), RPL13A(2), RPL14(2), RPL19(2), RPL21(1), RPL22L1(3), RPL23A(2), RPL24(1), RPL26(3), RPL27A(2), RPL28(2), RPL29(1), RPL3(3), RPL30(2), RPL31(1), RPL34(1), RPL36A(2), RPL36AL(1), RPL37(2), RPL3L(8), RPL41(1), RPL6(4), RPL7(2), RPL8(3), RPL9(1), RPS10(3), RPS11(1), RPS13(1), RPS18(2), RPS2(2), RPS20(1), RPS25(2), RPS26(1), RPS27(1), RPS28(1), RPS29(1), RPS3(5), RPS3A(2), RPS4Y1(1), RPS5(2), RPS6(3), RPS7(1), RPSA(1)	17333526	93	80	91	30	16	31	17	8	21	0	0.606	1.000	1.000
460	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	15	AKT1(3), AKT2(7), AKT3(7), BPNT1(7), GRB2(6), ILK(1), MAPK1(2), MAPK3(3), PDK1(6), PIK3CD(4), PTEN(11), PTK2B(14), RBL2(5), SHC1(6), SOS1(17)	14585402	99	80	96	33	13	39	24	9	14	0	0.690	1.000	1.000
461	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	5	C3(13), C5(6), C6(29), C8A(18), C9(20)	8883651	86	79	86	33	11	34	17	7	16	1	0.903	1.000	1.000
462	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(6), GALNS(3), GLB1(3), GNS(1), GUSB(5), HEXA(6), IDS(7), IDUA(1), LCT(50), NAGLU(5)	11432703	87	78	86	30	13	43	10	9	12	0	0.536	1.000	1.000
463	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	14	AKT1(3), GRB2(6), HRAS(2), IGF1R(8), IRS1(20), MAP2K1(10), MAPK1(2), MAPK3(3), PIK3R1(4), RAF1(6), SHC1(6), SOS1(17), YWHAH(1)	13516061	88	78	82	26	13	33	18	10	14	0	0.423	1.000	1.000
464	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(4), CREB1(2), CREBBP(30), EP300(11), NCOA3(14), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), RARA(7), RXRA(1)	16607315	93	77	93	21	14	37	20	8	13	1	0.114	1.000	1.000
465	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(3), BCAT2(2), IARS(9), IARS2(15), ILVBL(3), LARS(14), LARS2(2), PDHA1(5), PDHA2(29), VARS(10), VARS2(2)	14999013	94	77	93	26	12	35	15	11	21	0	0.334	1.000	1.000
466	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(4), ALDOB(8), ALDOC(2), FBP1(2), FBP2(2), G6PD(4), GPI(8), H6PD(5), PFKM(7), PFKP(5), PGD(2), PGLS(1), PGM1(3), PGM3(3), PRPS1(3), PRPS1L1(3), PRPS2(4), RBKS(1), RPE(3), RPIA(8), TAL1(7), TALDO1(1), TKT(3)	16397956	89	77	89	26	12	27	19	13	18	0	0.327	1.000	1.000
467	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	11	CREBBP(30), DAXX(8), HRAS(2), PAX3(10), PML(12), RARA(7), SIRT1(2), SP100(18), TNF(2), TNFRSF1B(2)	13175932	93	77	93	17	16	32	24	8	13	0	0.0194	1.000	1.000
468	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	14	AKT1(3), AKT2(7), AKT3(7), CDKN1A(2), ELK1(3), GRB2(6), HRAS(2), MAP2K1(10), MAP2K2(1), NGFR(5), NTRK1(14), PIK3CD(4), SHC1(6), SOS1(17)	11082729	87	77	82	26	11	35	22	9	9	1	0.385	1.000	1.000
469	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	16	ADRB2(4), AKT1(3), ANXA1(1), CALM1(3), CALM2(1), GNAS(29), GNB1(2), GNGT1(6), NFKB1(6), NOS3(12), NPPA(3), NR3C1(8), PIK3R1(4), RELA(3), SYT1(6)	12457063	91	76	87	26	17	34	16	5	19	0	0.362	1.000	1.000
470	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	30	ANPEP(10), G6PD(4), GCLC(13), GGT1(1), GPX3(2), GPX5(7), GSS(4), GSTA1(7), GSTA2(7), GSTA3(2), GSTA4(2), GSTM1(1), GSTM2(4), GSTM3(2), GSTM4(1), GSTM5(3), GSTO2(3), GSTP1(2), GSTT1(1), GSTZ1(2), IDH1(6), IDH2(2), MGST1(1), MGST2(2), MGST3(2), PGD(2)	14510190	93	76	93	16	11	36	12	7	27	0	0.00372	1.000	1.000
471	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(7), ACAD9(5), ADH1A(8), ADH1B(12), ADH4(4), ADH5(2), ADH6(8), ADH7(11), ADHFE1(5), DHRS2(6), DHRS3(2), DHRS7(3), DHRSX(3), ESCO1(10), ESCO2(4), NAT6(1), PNPLA3(4)	20146303	95	76	92	30	6	39	20	8	22	0	0.648	1.000	1.000
472	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CHUK(7), CREBBP(30), EP300(11), FADD(2), HDAC3(3), IKBKB(9), NFKB1(6), NFKBIA(4), RELA(3), RIPK1(11), TNF(2), TNFRSF1B(2), TRADD(2), TRAF6(6)	17978878	98	76	98	32	11	30	23	11	23	0	0.666	1.000	1.000
473	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3D(2), CD3E(2), CD4(8), FYN(8), HLA-DRA(3), HLA-DRB1(5), LCK(9), PTPRC(41), ZAP70(9)	7299922	87	76	83	27	10	28	15	5	29	0	0.690	1.000	1.000
474	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	16	CD28(4), CD3D(2), CD3E(2), CD80(3), CD86(11), CTLA4(3), GRB2(6), HLA-DRA(3), HLA-DRB1(5), ICOS(5), IL2(7), ITK(16), LCK(9), PIK3R1(4), PTPN11(9)	8593095	89	75	84	24	6	33	13	10	27	0	0.478	1.000	1.000
475	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(2), CAT(3), EPX(14), LPO(7), MPO(15), MTHFR(7), PRDX6(5), SHMT1(2), SHMT2(2), TPO(33)	9328337	90	75	89	38	19	32	16	9	14	0	0.832	1.000	1.000
476	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(20), CPT1A(11), LEP(4), LEPR(26), PRKAA1(6), PRKAA2(8), PRKAB1(3), PRKAG1(1), PRKAG2(5)	11717314	84	75	83	28	9	29	23	6	17	0	0.796	1.000	1.000
477	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	22	CALM1(3), CALM2(1), CAMK1(1), CAMK1G(2), CAMK2A(3), CAMK2B(16), CAMK2D(7), CAMK4(16), HDAC5(5), MEF2A(2), MEF2B(2), MEF2C(6), MEF2D(4), PPARA(4), PPP3CB(3), PPP3CC(3), SLC2A4(4), SYT1(6), YWHAH(1)	15291069	89	75	89	22	8	33	15	10	23	0	0.204	1.000	1.000
478	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(12), IL13(2), IL4(1), IL5(2), JUNB(1), MAF(3), MAP2K3(13), MAPK14(4), NFATC1(9), NFATC2(15), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2)	9567274	86	74	85	35	15	36	16	4	14	1	0.776	1.000	1.000
479	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	BET1(2), BNIP1(3), GOSR1(2), GOSR2(3), SNAP23(3), SNAP25(5), SNAP29(1), STX11(3), STX12(3), STX16(5), STX17(4), STX18(3), STX19(3), STX2(8), STX3(6), STX4(1), STX5(3), STX6(3), STX7(3), STX8(2), TSNARE1(8), USE1(2), VAMP3(1), VAMP4(2), VAMP5(1), VAMP7(4), VAMP8(1), VTI1A(2), VTI1B(1), YKT6(1)	13367893	89	74	89	26	7	28	20	12	22	0	0.501	1.000	1.000
480	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(4), CYP51A1(5), DHCR24(3), DHCR7(6), EBP(3), FDFT1(4), FDPS(5), GGCX(7), GGPS1(2), HMGCR(5), HSD17B7(3), IDI1(2), IDI2(1), LSS(10), MVD(2), MVK(4), NSDHL(7), PMVK(2), SQLE(4), TM7SF2(6)	15429563	85	73	83	26	13	24	21	11	16	0	0.459	1.000	1.000
481	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(8), ADH1B(12), ADH4(4), ADH5(2), ADH6(8), ADH7(11), ADHFE1(5), ALDH1A3(4), ALDH1B1(12), ALDH2(3), ALDH3A1(5), ALDH3A2(6), ALDH7A1(3), ALDH9A1(3)	10651830	86	73	83	24	7	39	17	6	17	0	0.296	1.000	1.000
482	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(14), GBA(7), LPO(7), MPO(15), PRDX6(5), TPO(33)	6754499	81	73	80	38	16	28	15	9	13	0	0.939	1.000	1.000
483	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	20	AKT1(3), BCL2L1(3), CASP9(6), CDC42(1), CHUK(7), ELK1(3), H2AFX(3), HRAS(2), MAP2K1(10), MAPK3(3), NFKB1(6), PIK3R1(4), RAF1(6), RALA(5), RALBP1(3), RALGDS(5), RELA(3), RHOA(4)	13475906	77	73	73	24	7	29	14	10	17	0	0.502	1.000	1.000
484	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	13	ACTR2(4), ACTR3(2), ARPC1A(3), ARPC1B(4), ARPC2(3), ARPC3(2), CDC42(1), PAK1(9), PDGFRA(41), PIK3R1(4), WASL(7)	9049510	80	72	78	30	8	24	16	7	24	1	0.916	1.000	1.000
485	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	B3GNT1(3), B3GNT2(4), B3GNT3(5), B3GNT4(2), B3GNT5(5), B4GALT1(1), B4GALT2(4), B4GALT3(2), B4GALT4(2), FUT1(4), FUT2(1), FUT3(5), FUT5(3), FUT6(4), FUT7(3), FUT9(15), GCNT2(5), ST3GAL6(6), ST8SIA1(6)	12770463	80	72	79	25	9	37	14	8	12	0	0.293	1.000	1.000
486	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(1), JAK1(11), JAK2(16), JAK3(10), PIAS1(2), PIAS3(7), PTPRU(19), REG1A(20), SOAT1(8)	10944552	94	72	92	28	13	33	16	11	21	0	0.392	1.000	1.000
487	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	CARM1(4), DHRS2(6), DHRS3(2), DHRS7(3), DHRSX(3), LCMT1(5), LCMT2(7), METTL2B(5), METTL6(1), PRMT2(2), PRMT3(8), PRMT5(7), PRMT6(7), PRMT7(4), PRMT8(13), WBSCR22(3)	12061465	80	71	78	31	15	22	19	9	15	0	0.811	1.000	1.000
488	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	9	EGF(13), MAP2K1(10), MAP3K1(7), MAPK14(4), NCOR2(30), RARA(7), RXRA(1), THRA(5), THRB(4)	11512200	81	70	79	25	7	27	21	9	17	0	0.632	1.000	1.000
489	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(4), IFNB1(7), JAK1(11), PTPRU(19), REG1A(20), STAT1(7), STAT2(6), TYK2(5)	10025136	79	70	77	18	9	37	8	10	15	0	0.0398	1.000	1.000
490	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(7), DUSP1(1), IKBKAP(6), IKBKB(9), LTA(3), MAP3K1(7), NFKB1(6), NFKBIA(4), RELA(3), RIPK1(11), TANK(3), TNFAIP3(6), TNFRSF1B(2), TRAF1(2), TRAF2(5), TRAF3(4)	18085983	79	70	79	33	8	25	21	9	16	0	0.954	1.000	1.000
491	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	11	AKT1(3), GRB2(6), HRAS(2), KLK2(10), NTRK1(14), PIK3R1(4), PLCG1(7), PRKCA(10), SHC1(6), SOS1(17)	10778981	79	70	75	29	13	29	18	7	11	1	0.772	1.000	1.000
492	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(5), GNAQ(5), GNB1(2), GNGT1(6), HTR2C(8), PLCB1(52), TUB(11)	5767938	89	70	88	27	9	44	14	8	14	0	0.416	1.000	1.000
493	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(4), CHAT(22), CHKA(4), PCYT1A(2), PDHA1(5), PDHA2(29), PEMT(2), SLC18A3(19)	5570894	87	69	86	35	18	38	15	3	13	0	0.756	1.000	1.000
494	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(3), B3GNT2(4), B3GNT7(5), B4GALT1(1), B4GALT2(4), B4GALT3(2), B4GALT4(2), CHST1(17), CHST2(14), CHST4(3), CHST6(7), FUT8(7), ST3GAL1(4), ST3GAL2(4), ST3GAL3(4), ST3GAL4(4)	9963065	85	69	84	41	14	31	21	6	13	0	0.950	1.000	1.000
495	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	6	AKT1(3), PIK3R1(4), PLCB1(52), PLCG1(7), PRKCA(10), VAV1(8)	8579464	84	69	82	22	10	39	13	6	16	0	0.185	1.000	1.000
496	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(20), ACACB(28), FASN(18), MCAT(3), OLAH(8), OXSM(5)	12381899	82	68	82	27	15	32	14	7	14	0	0.502	1.000	1.000
497	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(5), AOC2(6), AOC3(11), CES1(8), DDHD1(11), ESCO1(10), ESCO2(4), LIPA(2), NAT6(1), PLA1A(6), PNPLA3(4), PPME1(6), PRDX6(5)	20439259	79	68	79	24	12	24	17	13	13	0	0.565	1.000	1.000
498	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(9), APAF1(10), BCL2(5), CASP3(5), CASP9(6), CYCS(2), DAXX(8), FAS(4), FASLG(10), HSPB1(1), HSPB2(1), IL1A(4), MAPKAPK2(2), MAPKAPK3(3), TNF(2)	9129702	72	68	72	30	2	34	18	10	8	0	0.939	1.000	1.000
499	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	20	AKT1(3), CCND1(3), CCNE1(7), CDK2(1), CDK4(3), CDK6(5), CDKN1A(2), CDKN1B(5), E2F1(3), HRAS(2), MAPK1(2), MAPK3(3), NFKB1(6), NFKBIA(4), PAK1(9), PIK3R1(4), RAF1(6), RELA(3), TFDP1(10)	13040149	81	68	75	26	10	28	15	5	23	0	0.567	1.000	1.000
500	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	7	CD44(7), ICAM1(2), ITGAL(26), ITGAM(24), ITGB2(8), SELL(9)	7363639	76	67	74	33	8	39	17	3	9	0	0.870	1.000	1.000
501	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	16	AKT1(3), CREB1(2), GRB2(6), HRAS(2), MAPK1(2), MAPK3(3), MAPK7(7), MEF2A(2), MEF2B(2), MEF2C(6), MEF2D(4), NTRK1(14), PIK3R1(4), PLCG1(7), RPS6KA1(6), SHC1(6)	13443911	76	66	74	24	16	26	14	6	13	1	0.416	1.000	1.000
502	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	15	AKT1(3), BCAR1(3), CDKN1B(5), GRB2(6), ILK(1), ITGB1(6), MAPK1(2), MAPK3(3), PDK2(3), PDPK1(3), PIK3R1(4), PTEN(11), PTK2(6), SHC1(6), SOS1(17)	13693137	79	66	76	26	8	27	17	11	16	0	0.721	1.000	1.000
503	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(10), ARHGAP5(17), ARHGDIB(2), CASP1(8), CASP10(7), CASP3(5), CASP8(6), CASP9(6), CYCS(2), GZMB(6), JUN(3), PRF1(8)	10442703	80	65	80	26	3	35	16	14	12	0	0.786	1.000	1.000
504	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(3), GRB2(6), IL2RG(5), IL4(1), IL4R(10), IRS1(20), JAK1(11), JAK3(10), RPS6KB1(3), SHC1(6), STAT6(2)	11837408	77	65	76	28	15	28	14	11	9	0	0.700	1.000	1.000
505	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(4), ACADM(8), ACADS(1), ACADVL(2), ACSL1(12), ACSL3(4), ACSL4(7), CPT1A(11), CPT2(3), EHHADH(13), HADHA(3), PECR(3), SCP2(4), SLC25A20(1)	13533556	76	64	75	17	11	23	13	13	16	0	0.144	1.000	1.000
506	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(1), CAMK1G(2), HDAC9(48), MEF2A(2), MEF2B(2), MEF2C(6), MEF2D(4), MYOD1(7), YWHAH(1)	6195060	73	64	73	24	8	28	13	6	16	2	0.627	1.000	1.000
507	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(15), CD44(7), CSF1(1), FCGR3A(9), IL1B(1), IL6R(8), SELL(9), SPN(4), TGFB1(3), TGFB2(10), TNF(2), TNFRSF1B(2), TNFRSF8(11), TNFSF8(1)	10550242	83	64	81	28	8	40	15	6	14	0	0.407	1.000	1.000
508	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(8), ENO1(7), GPI(8), HK1(12), PFKL(9), PGAM1(1), PGK1(4), PKLR(16), TPI1(9)	7359403	74	63	74	24	13	24	19	5	13	0	0.418	1.000	1.000
509	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(5), CYSLTR2(12), GPR161(6), GPR171(2), GPR18(4), GPR34(5), GPR39(6), GPR45(14), GPR65(14), GPR68(1), GPR75(5)	7970124	74	63	73	23	9	29	23	4	9	0	0.376	1.000	1.000
510	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	14	AKT1(3), CREB1(2), MAP2K1(10), MAP2K2(1), MAP2K3(13), MAP2K6(5), MAP3K1(7), MAPK1(2), MAPK14(4), MAPK3(3), NFKB1(6), PIK3R1(4), RELA(3), SP1(6)	12428527	69	63	67	24	3	25	15	6	20	0	0.780	1.000	1.000
511	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(4), CHPT1(3), LCMT1(5), LCMT2(7), METTL2B(5), METTL6(1), PCYT1A(2), PCYT1B(3), PRMT2(2), PRMT3(8), PRMT5(7), PRMT6(7), PRMT7(4), PRMT8(13), WBSCR22(3)	11287042	74	63	72	29	15	19	19	8	13	0	0.852	1.000	1.000
512	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARF1(1), ARFGAP1(5), ARFGAP3(5), ARFGEF2(14), CLTA(1), COPA(14), GBF1(17), GPLD1(10), KDELR1(1), KDELR3(3)	13048441	71	62	71	17	7	25	18	11	10	0	0.226	1.000	1.000
513	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(9), CYP11A1(5), CYP11B2(24), CYP17A1(6), HSD11B1(9), HSD3B1(6), HSD3B2(15)	5575349	74	62	73	29	13	28	16	6	10	1	0.567	1.000	1.000
514	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM1(3), CALM2(1), CCL2(2), CCL4(2), CCR5(4), CXCL12(3), CXCR4(6), FOS(3), GNAQ(5), JUN(3), MAPK14(4), MAPK8(2), PLCG1(7), PRKCA(10), PTK2B(14), SYT1(6)	11118315	75	61	75	23	11	30	12	6	16	0	0.437	1.000	1.000
515	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(4), CARS2(3), CTH(2), GOT1(3), GOT2(6), LDHA(10), LDHAL6A(1), LDHAL6B(3), LDHB(4), LDHC(6), SDS(4), SULT1B1(10), SULT1C2(3), SULT1C4(2), SULT4A1(6)	10064685	67	61	67	24	6	32	11	5	13	0	0.790	1.000	1.000
516	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(10), BIRC2(2), BIRC3(4), CASP10(7), CASP3(5), CASP7(3), CASP8(6), CASP9(6), DFFA(3), DFFB(4), GZMB(6), PRF1(8), SCAP(6), SREBF1(3), SREBF2(2)	14452849	75	61	75	22	1	26	18	12	18	0	0.579	1.000	1.000
517	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	CYP51A1(5), DHCR7(6), FDFT1(4), FDPS(5), HMGCR(5), HMGCS1(11), IDI1(2), LSS(10), MVD(2), MVK(4), NSDHL(7), PMVK(2), SQLE(4)	10504983	67	60	65	20	11	18	16	7	14	1	0.497	1.000	1.000
518	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	12	AKT1(3), CHRNB1(5), CHRNG(7), MUSK(12), PIK3R1(4), PTK2(6), PTK2B(14), RAPSN(3), SRC(2), TERT(7), YWHAH(1)	11302945	64	59	63	23	12	21	11	7	13	0	0.506	1.000	1.000
519	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	13	AKT1(3), CASP9(6), CHUK(7), GH1(7), GHR(19), NFKB1(6), NFKBIA(4), PDPK1(3), PIK3R1(4), PPP2CA(1), RELA(3), YWHAH(1)	9573891	64	59	63	26	2	28	10	6	18	0	0.905	1.000	1.000
520	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	HS3ST1(8), HS3ST2(7), HS3ST3A1(7), XYLT1(44), XYLT2(3)	5218640	69	59	68	35	20	18	15	7	9	0	0.908	1.000	1.000
521	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	HS3ST1(8), HS3ST2(7), HS3ST3A1(7), XYLT1(44), XYLT2(3)	5218640	69	59	68	35	20	18	15	7	9	0	0.908	1.000	1.000
522	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(5), ACO2(3), AFMID(4), CS(2), GRHPR(4), HAO1(12), HAO2(7), MDH1(3), MDH2(3), MTHFD1(6), MTHFD1L(12), MTHFD2(2)	10822334	63	59	62	24	8	22	11	8	14	0	0.712	1.000	1.000
523	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(2), CLOCK(4), CRY1(7), CRY2(6), CSNK1D(7), CSNK1E(6), NPAS2(5), NR1D1(2), PER1(10), PER2(11), PER3(11)	13642370	71	59	69	18	8	28	17	6	11	1	0.282	1.000	1.000
524	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	18	AKT1(3), EIF2S2(3), EIF2S3(3), EIF4E(4), GSK3B(4), IGF1(4), IGF1R(8), INPPL1(11), PDK2(3), PDPK1(3), PIK3R1(4), PPP2CA(1), PTEN(11), RPS6(3), RPS6KB1(3)	14075259	68	59	67	20	8	29	11	6	14	0	0.423	1.000	1.000
525	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(2), GNAS(29), GNB1(2), GNGT1(6), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2), PRKCA(10)	7619071	73	58	70	21	23	28	11	5	5	1	0.455	1.000	1.000
526	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(3), BLVRB(2), HMOX1(3), IL10(2), IL10RA(6), IL10RB(6), IL1A(4), IL6(2), JAK1(11), STAT1(7), STAT3(11), STAT5A(3), TNF(2)	9843447	62	58	62	16	4	15	15	13	15	0	0.461	1.000	1.000
527	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	12	AKT1(3), CAT(3), GH1(7), GHR(19), HRAS(2), IGF1(4), IGF1R(8), PIK3R1(4), SHC1(6), SOD1(1), SOD2(6), SOD3(1)	8940033	64	58	62	19	5	31	11	4	13	0	0.347	1.000	1.000
528	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	18	APAF1(10), BAK1(3), BAX(3), BCL2(5), BCL2L1(3), BID(2), BIRC2(2), BIRC3(4), CASP3(5), CASP6(3), CASP7(3), CASP8(6), CASP9(6), CYCS(2), DFFA(3), DFFB(4), DIABLO(1)	10829222	65	58	65	24	2	26	17	6	14	0	0.925	1.000	1.000
529	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	CDC34(2), NRF1(8), UBE2A(7), UBE2B(1), UBE2C(3), UBE2D1(1), UBE2D2(1), UBE2D3(3), UBE2E3(6), UBE2G2(1), UBE2I(2), UBE2J1(3), UBE2L3(1), UBE2L6(1), UBE2M(1), UBE2N(1), UBE2S(2), UBE3A(18)	8388658	62	58	61	19	4	27	12	6	13	0	0.574	1.000	1.000
530	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	9	CD3D(2), CD3E(2), GZMB(6), HLA-A(8), ICAM1(2), ITGAL(26), ITGB2(8), PRF1(8)	6816006	62	57	62	25	8	20	16	5	13	0	0.779	1.000	1.000
531	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(26), GNAS(29), GNB1(2), GNGT1(6), PRKACA(3), PRKAR1A(2)	5210467	68	57	65	24	22	23	11	4	6	2	0.704	1.000	1.000
532	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(5), ASPH(6), COPS5(3), CREB1(2), EDN1(1), EP300(11), EPO(6), HIF1A(2), JUN(3), LDHA(10), NOS3(12), P4HB(5), VHL(1)	13589874	67	57	67	21	4	19	18	3	23	0	0.769	1.000	1.000
533	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(1), B3GALNT1(2), B3GALT5(3), FUT1(4), FUT2(1), FUT9(15), GBGT1(2), GLA(9), HEXA(6), NAGA(4), ST3GAL1(4), ST3GAL2(4), ST8SIA1(6)	8572537	61	57	61	31	10	22	17	5	7	0	0.945	1.000	1.000
534	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT1(2), ACAT2(2), ACOT11(4), ACYP2(1), DHRS2(6), DHRS3(2), DHRS7(3), DHRSX(3), ECHS1(4), EHHADH(13), ESCO1(10), ESCO2(4), FN3K(1), GCDH(7), HADHA(3), NAT6(1), PNPLA3(4), YOD1(1)	20889072	71	57	69	23	9	22	18	8	14	0	0.706	1.000	1.000
535	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP5E(1), ATP5O(1), ATP6AP1(3), ATP6V0A1(6), ATP6V0A4(8), ATP6V0B(2), ATP6V0C(4), ATP6V0D1(2), ATP6V1A(6), ATP6V1B1(3), ATP6V1B2(5), ATP6V1C1(7), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3), FDXR(3), SHMT1(2)	12868967	66	57	65	28	9	28	8	8	12	1	0.858	1.000	1.000
536	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	20	CCNA1(7), CCNB1(2), CCND1(3), CCND2(4), CCND3(1), CCNE1(7), CCNH(3), CDC25A(4), CDK2(1), CDK4(3), CDK6(5), CDK7(3), CDKN1A(2), CDKN1B(5), CDKN2D(2), E2F1(3), RBL1(7), TFDP1(10)	10968375	72	56	71	20	6	28	14	9	15	0	0.416	1.000	1.000
537	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(1), FUT1(4), FUT2(1), FUT9(15), GBGT1(2), GLA(9), HEXA(6), NAGA(4), ST3GAL1(4), ST3GAL2(4), ST3GAL4(4), ST8SIA1(6)	8067073	60	56	60	29	7	21	18	5	9	0	0.925	1.000	1.000
538	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(30), EP300(11), ESR1(12), MAPK1(2), MAPK3(3), PELP1(10), SRC(2)	11815841	70	56	70	17	14	25	17	2	12	0	0.147	1.000	1.000
539	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(3), FOSL1(4), FOSL2(3), IFNAR1(4), IFNAR2(7), IFNB1(7), MAPK8(2), NFKB1(6), RELA(3), TNFRSF11A(9), TNFSF11(5), TRAF6(6)	8948107	59	56	59	15	4	22	14	6	13	0	0.397	1.000	1.000
540	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	12	ABL1(9), E2F1(3), MDM2(5), MYC(4), PIK3R1(4), POLR1A(13), POLR1B(11), POLR1D(2), TBX2(8), TWIST1(2)	11959402	61	55	60	22	13	18	15	4	11	0	0.704	1.000	1.000
541	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(5), ACO2(3), CS(2), GRHPR(4), HAO1(12), HAO2(7), MDH1(3), MDH2(3), MTHFD1(6), MTHFD1L(12), MTHFD2(2)	10332673	59	55	58	22	6	20	11	8	14	0	0.710	1.000	1.000
542	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(9), ANKRD1(6), CYR61(2), DUSP14(2), EIF4E(4), IFNG(7), IFRD1(4), IL1A(4), IL1R1(2), JUND(1), MYOG(1), NR4A3(7), WDR1(9)	8580866	58	55	58	17	4	19	15	8	11	1	0.607	1.000	1.000
543	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5E(1), ATP5O(1), ATP6AP1(3), ATP6V0A1(6), ATP6V0A4(8), ATP6V0B(2), ATP6V0C(4), ATP6V0D1(2), ATP6V1A(6), ATP6V1B1(3), ATP6V1B2(5), ATP6V1C1(7), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3), SHMT1(2)	12120625	63	54	62	24	9	26	8	8	11	1	0.705	1.000	1.000
544	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(7), DUSP1(1), IKBKAP(6), IKBKB(9), MAP3K1(7), NFKB1(6), NFKBIA(4), RELA(3), TNFAIP3(6), TRAF3(4), TRAF6(6)	14639467	59	54	59	28	5	18	14	7	15	0	0.986	1.000	1.000
545	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5E(1), ATP5O(1), ATP6AP1(3), ATP6V0A1(6), ATP6V0A4(8), ATP6V0B(2), ATP6V0C(4), ATP6V0D1(2), ATP6V1A(6), ATP6V1B1(3), ATP6V1B2(5), ATP6V1C1(7), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3), SHMT1(2)	12120625	63	54	62	24	9	26	8	8	11	1	0.705	1.000	1.000
546	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5E(1), ATP5O(1), ATP6AP1(3), ATP6V0A1(6), ATP6V0A4(8), ATP6V0B(2), ATP6V0C(4), ATP6V0D1(2), ATP6V1A(6), ATP6V1B1(3), ATP6V1B2(5), ATP6V1C1(7), ATP6V1C2(2), ATP6V1D(2), ATP6V1E1(1), ATP6V1F(3), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3), SHMT1(2)	12120625	63	54	62	24	9	26	8	8	11	1	0.705	1.000	1.000
547	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(15), AGT(4), AGTR1(9), AGTR2(6), BDKRB2(3), KNG1(9), NOS3(12), REN(6)	7816341	64	53	64	32	8	31	11	6	8	0	0.896	1.000	1.000
548	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(5), CDKN1A(2), EPO(6), EPOR(2), GRIN1(9), HIF1A(2), JAK2(16), NFKB1(6), NFKBIA(4), RELA(3), SOD2(6)	10072951	61	53	60	19	3	20	18	5	15	0	0.684	1.000	1.000
549	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(5), ACOX3(8), FADS2(4), PLA2G12A(4), PLA2G12B(3), PLA2G1B(2), PLA2G2A(5), PLA2G2D(1), PLA2G2E(2), PLA2G2F(3), PLA2G3(6), PLA2G4A(21), PLA2G6(3)	8123278	67	53	67	24	6	28	17	8	8	0	0.710	1.000	1.000
550	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(11), JAK2(16), JAK3(10), MAPK1(2), MAPK3(3), STAT3(11), TYK2(5)	9257582	58	53	58	21	7	15	13	12	11	0	0.789	1.000	1.000
551	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(3), CYP2A13(13), CYP2A6(6), CYP2A7(7), NAT1(4), NAT2(5), XDH(18)	6470567	56	52	56	23	7	28	10	7	4	0	0.633	1.000	1.000
552	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(6), HK1(12), HK2(11), HK3(22), IMPA1(1), IMPA2(1), ISYNA1(1), PGM1(3), PGM3(3), TGDS(1)	9290356	61	52	61	26	17	19	11	6	8	0	0.811	1.000	1.000
553	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	AKR1A1(1), ECHS1(4), EHHADH(13), HADH(2), HADHA(3), HSD17B10(2), HSD17B4(8), SIRT1(2), SIRT2(2), SIRT5(1), SIRT7(4), VNN2(14)	9526617	56	52	54	15	8	19	13	5	11	0	0.436	1.000	1.000
554	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(11), POLR2A(11), POLR2B(10), POLR2C(4), POLR2D(3), POLR2E(2), POLR2F(1), POLR2G(1), POLR2H(2), POLR2I(1), POLR2J(1), POLR2K(2), POLRMT(8)	10638297	57	52	57	19	7	19	16	5	10	0	0.686	1.000	1.000
555	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACOX1(5), ACOX3(8), ELOVL2(6), ELOVL5(1), ELOVL6(2), FADS2(4), FASN(18), HADHA(3), HSD17B12(4), PECR(3), SCD(3)	11182281	57	51	57	14	9	23	10	8	7	0	0.171	1.000	1.000
556	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	ALDOA(4), CTSD(3), ESR1(12), GREB1(31), HSPB1(1), HSPB2(1), MTA1(6), MTA3(2), PDZK1(3), TUBA8(1)	8607341	64	51	63	25	13	19	15	3	14	0	0.632	1.000	1.000
557	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(1), CBS(1), CTH(2), GGT1(1), MARS(5), MARS2(13), MAT1A(7), MAT2B(3), PAPSS1(5), PAPSS2(10), SCLY(4), SEPHS1(4)	9934310	56	51	56	27	7	23	10	5	11	0	0.943	1.000	1.000
558	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(6), HK1(12), HK2(11), HK3(22), IMPA1(1), PGM1(3), PGM3(3), TGDS(1)	8218088	59	51	59	25	17	19	11	5	7	0	0.831	1.000	1.000
559	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREB1(2), CREM(3), FOS(3), JUN(3), MAPK3(3), OPRK1(12), POLR2A(11), PRKACB(9), PRKACG(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(3), PRKAR2B(2)	10358187	61	50	61	27	11	23	14	6	6	1	0.926	1.000	1.000
560	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(2), ADSS(6), DHFR(2), HPRT1(1), IMPDH1(7), MTHFD2(2), OAZ1(1), POLB(4), POLD1(7), POLG(12), PRPS2(4), RRM1(6), SRM(2)	9912415	56	50	56	13	8	19	11	9	9	0	0.223	1.000	1.000
561	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	HRAS(2), MMP14(4), MMP2(24), MMP9(10), RECK(9), TIMP1(1), TIMP2(2), TIMP3(4), TIMP4(4)	6044842	60	50	60	24	9	22	15	4	10	0	0.792	1.000	1.000
562	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(3), IARS(9), LARS(14), LARS2(2), PDHA1(5), PDHA2(29)	8106531	62	50	62	19	8	26	9	7	12	0	0.669	1.000	1.000
563	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(4), PSMA3(2), PSMA4(2), PSMA5(1), PSMA6(4), PSMA7(5), PSMB1(2), PSMB5(1), PSMB6(1), PSMD14(2), RPN1(3), RPN2(4), UBE2A(7), UBE3A(18)	10426013	56	49	56	13	5	22	14	9	6	0	0.258	1.000	1.000
564	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(10), CKM(4), EIF4E(4), FBL(8), LDHA(10), LDHB(4), LDHC(6), MAPK14(4), NCL(10)	7183673	60	49	60	18	9	24	8	7	12	0	0.530	1.000	1.000
565	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	AKR1B10(10), DHRS2(6), DHRS3(2), DHRS7(3), DHRSX(3), HSD3B7(7), PON1(3), PON2(2), PON3(5), RDH11(4), RDH12(3), RDH13(1), RDH14(2)	7249371	51	48	51	18	5	24	11	3	8	0	0.583	1.000	1.000
566	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(3), ACO1(5), ACO2(3), ACSS1(5), ACSS2(4), FH(13), IDH1(6), IDH2(2), MDH1(3), MDH2(3), SUCLA2(5)	10748299	52	48	52	19	5	16	5	10	16	0	0.710	1.000	1.000
567	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNA1(2), IFNAR1(4), IFNAR2(7), IFNB1(7), JAK1(11), STAT1(7), STAT2(6), TYK2(5)	8678322	49	47	49	12	4	19	9	9	8	0	0.319	1.000	1.000
568	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(10), BAK1(3), BAX(3), BCL10(4), BCL2(5), BCL2L1(3), BCL2L11(4), BID(2), CASP9(6), CES1(8)	8626031	48	47	48	22	5	22	11	6	4	0	0.970	1.000	1.000
569	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(4), PSMA3(2), PSMA4(2), PSMA5(1), PSMA6(4), PSMA7(5), PSMB1(2), PSMB5(1), PSMB6(1), PSMC2(3), PSMD1(8), PSMD11(7), PSMD12(4), PSMD13(4), PSMD2(3), PSMD6(2)	12929204	53	45	53	10	5	27	10	5	6	0	0.117	1.000	1.000
570	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(6), FDFT1(4), FDPS(5), HMGCR(5), IDI1(2), LSS(10), MVD(2), MVK(4), NQO2(3), PMVK(2), SQLE(4)	8778102	47	44	45	18	9	11	11	8	8	0	0.787	1.000	1.000
571	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(3), CS(2), FH(13), IDH2(2), MDH1(3), OGDH(10), SDHA(8), SUCLA2(5)	7617727	46	44	45	16	7	14	7	6	12	0	0.607	1.000	1.000
572	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(3), AASDH(15), AASDHPPT(4), AASS(20), KARS(8)	5621956	50	44	50	17	5	25	9	7	4	0	0.754	1.000	1.000
573	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	CREB1(2), GRB2(6), HRAS(2), PTK2B(14), SHC1(6), SOS1(17), SRC(2)	7080935	49	43	47	14	9	15	13	6	6	0	0.461	1.000	1.000
574	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(12), GAD1(7), HDC(16), PNMT(1), TH(7), TPH1(8)	4758284	51	43	51	18	10	20	9	3	9	0	0.524	1.000	1.000
575	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(11), LDLR(9), MBTPS1(7), MBTPS2(7), SCAP(6), SREBF1(3), SREBF2(2)	9331112	45	43	45	14	5	14	13	4	7	2	0.572	1.000	1.000
576	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GSR(5), GSS(4), NFKB1(6), NOX1(8), RELA(3), SOD1(1), TNF(2), XDH(18)	8029467	47	42	47	21	3	22	11	6	5	0	0.903	1.000	1.000
577	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(2), CDC25A(4), CDC25B(1), CDC25C(8), CSK(2), GRB2(6), PRKCA(10), PTPRA(11), SRC(2)	7390964	46	42	46	18	8	17	8	5	8	0	0.752	1.000	1.000
578	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(9), CAPN1(2), CAPNS1(1), CAPNS2(2), CDK5(3), CDK5R1(3), CSNK1A1(2), CSNK1D(7), GSK3B(4), MAPT(15), PPP2CA(1)	7346627	49	41	49	19	8	22	9	4	6	0	0.785	1.000	1.000
579	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(9), ACTR2(4), ACTR3(2), ARPC1A(3), ARPC1B(4), ARPC2(3), ARPC3(2), CDC42(1), WASF1(10), WASL(7)	6550870	45	41	45	19	4	13	13	5	10	0	0.933	1.000	1.000
580	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(7), MAPK14(4), MAPK8(2), NFKB1(6), RELA(3), TNFRSF13B(3), TNFRSF13C(2), TNFSF13B(1), TRAF2(5), TRAF3(4), TRAF5(5), TRAF6(6)	11647677	48	41	48	26	5	13	9	7	14	0	0.996	1.000	1.000
581	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	4	EGF(13), ERBB3(11), NRG1(18), UBE2D1(1)	6181944	43	39	40	15	8	13	8	2	12	0	0.826	1.000	1.000
582	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(5), ACO2(3), FH(13), IDH1(6), IDH2(2), MDH1(3), MDH2(3), SDHB(1), SUCLA2(5)	7200223	41	39	41	15	3	14	3	8	13	0	0.715	1.000	1.000
583	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAD(1), ALAS1(2), ALAS2(6), CPO(4), FECH(4), GATA1(6), HBA2(2), HBB(9), HMBS(5), UROS(2)	6361596	41	38	41	25	2	21	8	3	7	0	0.992	1.000	1.000
584	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	9	CASP3(5), CASP7(3), DFFA(3), DFFB(4), GZMB(6), HMGB1(2), TOP2A(10), TOP2B(10)	7110700	43	38	43	10	1	10	11	5	16	0	0.625	1.000	1.000
585	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	6	EEA1(5), EGF(13), HGS(1), RAB5A(2), TF(13), TFRC(6)	8191740	40	36	39	14	3	17	13	3	4	0	0.869	1.000	1.000
586	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(2), ACAT2(2), BDH1(4), BDH2(2), HMGCL(1), HMGCS1(11), HMGCS2(7), OXCT1(7), OXCT2(2)	5814519	38	36	38	15	3	11	12	3	8	1	0.896	1.000	1.000
587	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(3), B4GALT1(1), B4GALT2(4), B4GALT3(2), B4GALT5(6), FUT8(7), ST3GAL1(4), ST3GAL2(4), ST3GAL3(4), ST3GAL4(4)	6322492	39	36	38	22	6	13	9	2	9	0	0.970	1.000	1.000
588	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(18), GNA12(1), PRKACB(9), PRKACG(4), PRKAG1(1), PRKAR2A(3), PRKAR2B(2)	8129650	38	34	38	11	5	15	10	4	4	0	0.637	1.000	1.000
589	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	B3GNT1(3), FUT1(4), FUT2(1), FUT9(15), GCNT2(5), ST8SIA1(6)	4888396	34	33	33	17	3	17	6	3	5	0	0.836	1.000	1.000
590	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(4), CTH(2), GOT1(3), GOT2(6), LDHA(10), LDHB(4), LDHC(6)	5511713	35	33	35	12	4	13	5	4	9	0	0.720	1.000	1.000
591	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(12), EIF2AK4(7), EIF2S2(3), EIF2S3(3), EIF5(1), GSK3B(4), PPP1CA(2)	9270131	32	32	32	11	2	14	5	3	8	0	0.825	1.000	1.000
592	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CASP3(5), CD36(4), FOS(3), FYN(8), JUN(3), MAPK14(4), THBS1(8)	5972133	35	31	35	10	5	11	6	2	11	0	0.591	1.000	1.000
593	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(4), CYCS(2), GPD2(9), NDUFA1(2), SDHA(8), SDHB(1), SDHD(3), UQCRC1(2)	5355877	31	30	30	17	8	11	8	0	4	0	0.982	1.000	1.000
594	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	FABP6(3), LDLR(9), NR0B2(3), NR1H3(4), NR1H4(14), RXRA(1)	4348769	34	30	34	13	7	13	9	2	3	0	0.640	1.000	1.000
595	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(10), APOBEC1(1), APOBEC2(1), APOBEC3A(3), APOBEC3B(3), APOBEC3C(1), APOBEC3F(1), APOBEC3G(5), APOBEC4(7)	5940270	32	30	31	14	5	12	4	4	7	0	0.870	1.000	1.000
596	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(3), PLCG1(7), PRKCA(10), PTK2B(14)	5418338	34	30	34	12	12	11	5	2	4	0	0.550	1.000	1.000
597	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(9), ADORA2A(3), ADORA2B(1), ADORA3(4), LTB4R(5), P2RY1(4), P2RY2(3), P2RY6(2)	4799440	31	30	31	15	10	6	6	4	5	0	0.807	1.000	1.000
598	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	CDK5(3), FOSB(2), GRIA2(28), JUND(1), PPP1R1B(1)	2959877	35	29	35	14	4	13	10	0	8	0	0.776	1.000	1.000
599	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(1), ALAS1(2), ALAS2(6), CPOX(4), FECH(4), HMBS(5), PPOX(7), UROS(2)	6125365	31	29	31	20	1	10	11	3	6	0	0.997	1.000	1.000
600	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	B3GALT1(5), B3GALT2(4), B3GALT5(3), B3GNT5(5), FUT1(4), FUT2(1), FUT3(5), ST3GAL3(4), ST3GAL4(4)	5787730	35	29	35	10	8	12	7	3	5	0	0.362	1.000	1.000
601	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS2(6), DHRS3(2), DHRS7(3), DHRSX(3), ESCO1(10), ESCO2(4), NAT6(1), PNPLA3(4)	13355738	33	29	33	15	2	10	9	4	8	0	0.957	1.000	1.000
602	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BIRC3(4), CASP8(6), FADD(2), RIPK1(11), TNF(2), TNFRSF1B(2), TRADD(2), TRAF2(5)	6647115	34	29	34	10	4	10	12	4	4	0	0.525	1.000	1.000
603	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(10), EPHX2(3), HSD3B7(7), RDH11(4), RDH12(3), RDH13(1), RDH14(2)	3845148	30	27	30	12	5	15	6	1	3	0	0.650	1.000	1.000
604	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(3), CS(2), MDH1(3), ME1(3), PC(9), PDHA1(5), SLC25A11(3)	7432397	28	27	28	11	4	7	4	9	4	0	0.739	1.000	1.000
605	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	8	CHUK(7), DNAJC3(5), EIF2S2(3), NFKB1(6), NFKBIA(4), RELA(3)	7195967	28	27	28	13	1	8	4	5	10	0	0.956	1.000	1.000
606	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	11	CREB1(2), FOS(3), FXYD2(1), JUN(3), MAFG(1), MAPK1(2), MAPK14(4), MAPK8(2), PRKCA(10)	5200078	28	26	28	12	4	8	8	1	7	0	0.909	1.000	1.000
607	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	AOC2(6), AOC3(11), CES1(8), ESD(2)	4884444	27	25	27	10	6	10	4	3	4	0	0.528	1.000	1.000
608	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(5), CHRNA1(16), SNAP25(5)	2633838	26	25	26	11	4	8	5	3	6	0	0.845	1.000	1.000
609	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(1), ST3GAL1(4), ST3GAL2(4), ST3GAL4(4), ST3GAL5(3), ST6GALNAC2(2), ST6GALNAC4(1), ST8SIA1(6)	4525222	25	25	25	18	2	5	10	1	7	0	0.996	1.000	1.000
610	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(2), CCL2(2), CSF1(1), IL6(2), LDLR(9), LPL(8)	4286004	24	23	24	11	5	7	4	5	3	0	0.872	1.000	1.000
611	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(4), PSMA3(2), PSMA4(2), PSMA5(1), PSMA6(4), PSMA7(5), PSMB1(2), PSMB10(1), PSMB5(1), PSMB6(1)	7053300	23	21	23	7	4	8	6	3	2	0	0.593	1.000	1.000
612	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	5	NFYA(1), NFYB(1), NFYC(6), SP1(6), SP3(6)	3973346	20	20	20	11	0	5	7	1	7	0	0.980	1.000	1.000
613	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	4	BCKDK(2), CBS(1), CTH(2), MUT(13)	3335407	18	18	18	14	3	6	4	1	4	0	0.993	1.000	1.000
614	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	4	BGN(6), DCN(5), FMOD(3), KERA(7)	2376887	21	17	21	11	2	4	9	4	2	0	0.939	1.000	1.000
615	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CCL2(2), CSF1(1), IL1B(1), MST1R(7), TNF(2)	5164336	13	13	13	9	1	7	0	3	2	0	0.931	1.000	1.000
616	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1	CMBL(1)	412157	1	1	1	2	0	0	0	1	0	0	0.987	1.000	1.000