rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 16 ABL1(5), CDKN2A(31), MDM2(2), PIK3CA(4), PIK3R1(1), POLR1A(3), POLR1B(3), RB1(3), TBX2(1), TP53(100) 4538065 153 108 113 4 28 21 21 25 58 0 6.45e-14 <1.00e-15 <8.55e-14 2 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 15 ARF1(1), ARF3(1), CDK4(2), CDKN2A(31), MDM2(2), NXT1(1), TP53(100) 1893625 138 106 98 2 28 17 17 21 55 0 1.99e-14 <1.00e-15 <8.55e-14 3 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 18 DNAJA3(1), IFNGR1(2), IKBKB(4), JAK2(6), LIN7A(1), NFKBIA(1), RB1(3), RELA(2), TNFRSF1A(2), TNFRSF1B(1), TP53(100), USH1C(1) 4102157 124 104 95 10 28 15 19 22 40 0 4.70e-07 <1.00e-15 <8.55e-14 4 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 16 APAF1(3), ATM(10), CCNE1(1), CDK4(2), MDM2(2), RB1(3), TP53(100) 4021908 121 103 93 3 29 15 18 23 36 0 1.09e-10 <1.00e-15 <8.55e-14 5 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 7 MAX(1), SP1(1), SP3(1), TP53(100) 1555114 103 102 75 0 25 12 13 19 34 0 7.99e-14 <1.00e-15 <8.55e-14 6 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 13 CREBBP(3), DAXX(3), HRAS(1), PML(2), RB1(3), SIRT1(1), SP100(3), TNFRSF1A(2), TNFRSF1B(1), TP53(100) 4264146 119 101 91 6 30 15 18 23 33 0 1.27e-09 <1.00e-15 <8.55e-14 7 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 9 CHUK(1), DNAJC3(2), NFKBIA(1), RELA(2), TP53(100) 2220923 106 101 78 2 25 13 13 21 34 0 3.12e-10 <1.00e-15 <8.55e-14 8 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 20 AKT1(1), APAF1(3), ATM(10), BAD(1), CASP3(2), CASP7(1), CASP9(1), PTK2(3), PXN(1), STAT1(3), TLN1(12), TP53(100) 6076312 138 104 110 6 35 20 17 25 40 1 1.50e-10 1.11e-15 8.55e-14 9 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 12 ATM(10), CDC25A(1), CDC25B(1), CDK4(2), MYT1(11), RB1(3), TP53(100), YWHAH(1) 3877709 129 104 101 4 32 16 19 25 37 0 3.17e-10 1.67e-15 1.14e-13 10 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 22 ATM(10), ATR(9), BRCA1(3), CCNB1(1), CDC25A(1), CDC25B(1), CDC34(1), EP300(6), MDM2(2), MYT1(11), PRKDC(7), TP53(100), YWHAH(1) 9364724 153 109 125 10 36 20 21 32 44 0 8.39e-09 2.11e-15 1.30e-13 11 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 19 ABCB1(5), AKT1(1), ATM(10), CSNK1D(1), FHL2(1), HIC1(2), HIF1A(1), MAPK8(2), MDM2(2), NFKBIB(1), TP53(100) 4637114 126 103 98 7 27 15 19 27 38 0 1.02e-08 2.33e-15 1.31e-13 12 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 25 ABL1(5), ATM(10), ATR(9), CCNA1(3), CCNE1(1), CDC25A(1), CDK4(2), CDK6(2), CDKN2A(31), DHFR(1), GSK3B(2), RB1(3), SKP2(3), TFDP1(1), TGFB1(1), TP53(100) 6699802 175 111 135 14 31 26 26 28 64 0 1.34e-08 2.66e-15 1.32e-13 13 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 19 ABL1(5), ATM(10), BRCA1(3), MAPK8(2), MDM2(2), MRE11A(2), NFKBIA(1), RAD50(1), RBBP8(3), RELA(2), TP53(100) 6591814 131 106 103 3 31 17 19 24 40 0 2.59e-11 2.78e-15 1.32e-13 14 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1QA(1), C1QB(35), C1R(1), C1S(6), C2(2), C3(11), C5(2), C6(6), C7(4), C8A(4), C9(2) 3891103 74 47 41 7 9 7 8 6 44 0 0.0436 3.00e-15 1.32e-13 15 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 21 ATM(10), ATR(9), BRCA1(3), BRCA2(7), FANCA(4), FANCC(1), FANCD2(5), FANCG(1), HUS1(1), MRE11A(2), RAD17(2), RAD50(1), TP53(100) 9672457 146 109 118 11 32 21 19 28 46 0 8.16e-07 3.89e-15 1.60e-13 16 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 7 ATM(10), ATR(9), TP53(100), YWHAH(1) 3507307 120 105 92 4 27 14 16 23 40 0 9.10e-08 4.55e-15 1.75e-13 17 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 41 APAF1(3), BAK1(1), BIRC2(2), CASP2(3), CASP3(2), CASP7(1), CASP8(2), CASP9(1), FASLG(1), MAP2K4(5), MAP3K1(3), MDM2(2), NFKBIA(1), PARP1(2), PRF1(1), RELA(2), TNFRSF1A(2), TNFRSF1B(1), TP53(100), TRADD(1), TRAF2(1) 8357997 137 104 109 13 33 17 24 24 39 0 2.48e-07 5.22e-15 1.86e-13 18 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 15 AKT1(1), EGFR(2), IGF1R(6), POLR2A(5), PPP2CA(1), RB1(3), TEP1(7), TERF1(1), TERT(5), TNKS(4), TP53(100), XRCC5(3) 6255053 138 106 110 12 40 17 16 26 39 0 2.80e-08 5.44e-15 1.86e-13 19 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1QA(1), C1QB(35), C1R(1), C1S(6), C2(2), C3(11), C5(2), C6(6), C7(4), C8A(4), C9(2), MASP1(2) 4732130 76 47 43 9 9 7 8 7 45 0 0.0854 6.77e-15 2.20e-13 20 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1QA(1), C1QB(35), C1R(1), C1S(6), C2(2), C3(11), C5(2), C6(6), C7(4), C8A(4), C9(2), MASP1(2) 4609907 76 47 43 7 9 7 8 7 45 0 0.0316 8.99e-15 2.77e-13 21 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 38 AKT1(1), CDC42(1), DUSP10(2), GCK(1), MAP2K4(5), MAP2K7(3), MAP3K1(3), MAP3K10(2), MAP3K12(2), MAP3K13(1), MAP3K2(2), MAP3K4(2), MAP3K5(1), MAP3K7(2), MAP3K9(6), MAPK7(4), MAPK8(2), MAPK9(1), MYEF2(2), NFATC3(2), NR2C2(1), PAPPA(3), SHC1(1), TP53(100), TRAF6(1), ZAK(2) 11240716 153 103 124 15 41 20 21 28 43 0 1.60e-07 5.16e-14 1.51e-12 22 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 65 APAF1(3), ATM(10), ATR(9), BAI1(5), CASP3(2), CASP8(2), CASP9(1), CCNB1(1), CCNB2(2), CCNB3(1), CCND2(3), CCND3(1), CCNE1(1), CCNE2(1), CCNG1(1), CCNG2(2), CDK4(2), CDK6(2), CDKN2A(31), DDB2(1), EI24(1), GTSE1(2), MDM2(2), MDM4(1), PERP(1), RFWD2(1), RRM2B(1), SERPINB5(2), SERPINE1(2), SESN1(1), SESN2(3), SESN3(2), STEAP3(3), THBS1(3), TNFRSF10B(2), TP53(100), TSC2(6), ZMAT3(2) 14634920 216 115 176 24 50 36 28 30 72 0 6.40e-09 3.52e-13 9.87e-12 23 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 66 APAF1(3), BAD(1), BAK1(1), BIRC2(2), CASP1(1), CASP10(3), CASP2(3), CASP3(2), CASP4(2), CASP7(1), CASP8(2), CASP9(1), CHUK(1), DFFB(1), FASLG(1), HELLS(1), IKBKB(4), IRF1(1), IRF2(1), IRF3(2), IRF5(1), IRF6(3), IRF7(2), MAP2K4(5), MAP3K1(3), MDM2(2), NFKBIA(1), NFKBIB(1), NFKBIE(1), PRF1(1), RELA(2), TNFRSF10B(2), TNFRSF1A(2), TNFRSF1B(1), TNFRSF21(2), TP53(100), TRADD(1), TRAF2(1) 12889076 165 109 137 17 39 25 27 27 47 0 4.28e-08 1.08e-12 2.89e-11 24 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(3), CCNA2(3), CCNE1(1), CCNE2(1), CDK4(2), CDKN2A(31), E2F4(3) 2029082 44 32 32 4 2 8 7 5 22 0 0.00877 4.21e-12 1.08e-10 25 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 82 ABL1(5), ATM(10), BUB1(3), BUB3(1), CCNA1(3), CCNA2(3), CCNB1(1), CCNB2(2), CCNB3(1), CCND2(3), CCND3(1), CCNE1(1), CCNE2(1), CDAN1(4), CDC14A(2), CDC14B(1), CDC25A(1), CDC25B(1), CDC6(1), CDC7(2), CDH1(1), CDK4(2), CDKN2A(31), E2F3(2), E2F4(3), E2F5(3), EP300(6), ESPL1(4), GSK3B(2), HDAC4(4), HDAC5(2), HDAC6(1), MAD1L1(1), MAD2L1(1), MCM2(6), MCM3(4), MCM5(2), MCM6(5), MCM7(1), MDM2(2), MPEG1(2), PRKDC(7), PTPRA(1), RB1(3), RBL1(2), SKP2(3), SMAD4(32), TBC1D8(3), TFDP1(1), TGFB1(1), TP53(100) 24567895 285 124 242 24 63 39 42 50 90 1 2.10e-13 4.04e-10 9.95e-09 26 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 28 BRAF(3), CPEB1(1), EGFR(2), ERBB2(6), ERBB4(6), ETS1(2), ETS2(2), ETV6(1), ETV7(1), FMN2(4), KRAS(126), NOTCH1(9), NOTCH2(6), NOTCH3(7), NOTCH4(5), PIWIL1(2), PIWIL2(3), PIWIL3(2), PIWIL4(1), SOS1(2), SOS2(1) 11749208 192 125 68 30 19 67 78 18 10 0 2.63e-06 2.49e-09 5.89e-08 27 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CCNA1(3), CCNB1(1), CCND2(3), CCND3(1), CCNE1(1), CDC25A(1), CDK4(2), CDK6(2), CDK7(1), CDKN2A(31), RB1(3), RBL1(2), TFDP1(1) 3597480 52 38 40 7 2 10 8 6 26 0 0.0317 1.10e-08 2.50e-07 28 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 81 AIFM1(1), AKT1(1), AKT2(2), AKT3(2), APAF1(3), ATM(10), BAD(1), BIRC2(2), CAPN1(1), CASP10(3), CASP3(2), CASP7(1), CASP8(2), CASP9(1), CFLAR(3), CHUK(1), CSF2RB(2), DFFB(1), FASLG(1), IKBKB(4), IL1B(1), IL1RAP(2), IL3RA(2), IRAK3(1), IRAK4(1), NFKB2(1), NFKBIA(1), NTRK1(2), PIK3CA(4), PIK3CB(1), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PPP3CA(2), PPP3CC(1), PPP3R1(1), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), RELA(2), TNFRSF10A(2), TNFRSF10B(2), TNFRSF1A(2), TP53(100), TRADD(1), TRAF2(1) 18722526 194 113 166 20 54 32 24 34 50 0 1.03e-09 3.38e-07 7.43e-06 29 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 65 ATM(10), CCNA1(3), CCNB1(1), CCND2(3), CCND3(1), CCNE1(1), CCNE2(1), CCNG2(2), CDC25A(1), CDK4(2), CDK7(1), CDKN2A(31), CREB3L1(1), CREB3L3(1), E2F3(2), E2F4(3), E2F5(3), GBA2(4), MCM2(6), MCM3(4), MCM5(2), MCM6(5), MCM7(1), MDM2(2), MYT1(11), NACA(8), POLA2(1), POLE(8), POLE2(5), PRIM1(1), RB1(3), RBL1(2), RPA1(1), RPA2(2), RPA3(1), TFDP1(1), TNXB(9), TP53(100) 17324559 244 112 202 27 58 34 38 41 72 1 2.94e-10 4.75e-07 1.01e-05 30 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 74 AKT1(1), AKT2(2), AKT3(2), BTK(1), FCER1A(1), GAB2(2), HRAS(1), INPP5D(1), KRAS(126), LCP2(3), MAP2K3(1), MAP2K4(5), MAP2K6(3), MAP2K7(3), MAPK11(1), MAPK12(1), MAPK13(1), MAPK8(2), MAPK9(1), MS4A2(3), PDK1(1), PIK3CA(4), PIK3CB(1), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PLA2G1B(1), PLA2G3(1), PLA2G6(4), PLCG1(1), PLCG2(7), PRKCD(4), PRKCE(1), RAC2(1), SOS1(2), SOS2(1), SYK(2), VAV1(4) 16063836 208 126 84 31 21 73 76 21 16 1 3.39e-08 1.67e-05 0.000342 31 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 62 AKT1(1), AKT2(2), AKT3(2), BLNK(1), BTK(1), CARD11(3), CD19(1), CD22(2), CD72(2), CD81(2), CHUK(1), CR2(5), FCGR2B(2), GSK3B(2), HRAS(1), IKBKB(4), INPP5D(1), KRAS(126), LILRB3(1), MALT1(4), NFAT5(4), NFATC1(4), NFATC2(3), NFATC3(2), NFATC4(5), NFKB2(1), NFKBIA(1), NFKBIB(1), NFKBIE(1), PIK3CA(4), PIK3CB(1), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PLCG2(7), PPP3CA(2), PPP3CC(1), PPP3R1(1), PTPN6(4), RAC2(1), RASGRP3(2), SYK(2), VAV1(4) 16554143 227 126 105 31 27 83 74 24 18 1 1.79e-10 5.08e-05 0.000987 32 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 69 AKT1(1), AKT2(2), AKT3(2), BAD(1), CASP9(1), CDC42(1), HRAS(1), KDR(1), KRAS(126), MAPK11(1), MAPK12(1), MAPK13(1), MAPKAPK3(1), NFAT5(4), NFATC1(4), NFATC2(3), NFATC3(2), NFATC4(5), NOS3(8), PIK3CA(4), PIK3CB(1), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PLA2G1B(1), PLA2G3(1), PLA2G6(4), PLCG1(1), PLCG2(7), PPP3CA(2), PPP3CC(1), PPP3R1(1), PRKCG(2), PTK2(3), PXN(1), RAC2(1), SH2D2A(1), SHC2(2), SPHK1(1), SRC(2) 16182739 214 125 92 31 26 78 79 19 12 0 1.57e-09 5.13e-05 0.000987 33 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA2A(1), ADORA3(6), LTB4R(3), P2RY1(6), P2RY2(1), P2RY6(1) 1319717 18 13 16 1 6 5 3 1 3 0 0.00473 9.13e-05 0.00170 34 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ADCY1(4), ADCY8(4), ARAF(2), BRAF(3), CACNA1C(8), CALML3(1), CAMK2D(1), CAMK4(1), CREBBP(3), EP300(6), GNAQ(1), GRIA1(1), GRIN1(1), GRIN2A(6), GRIN2B(7), GRIN2C(4), GRIN2D(5), GRM1(9), GRM5(7), HRAS(1), ITPR1(10), ITPR2(4), ITPR3(8), KRAS(126), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), PPP1CA(1), PPP3CA(2), PPP3CC(1), PPP3R1(1), PRKACB(1), PRKACG(3), PRKCG(2), RAP1B(3), RAPGEF3(3), RPS6KA2(2), RPS6KA3(1), RPS6KA6(4) 22417489 258 132 135 40 46 76 86 27 21 2 4.13e-10 0.00138 0.0250 35 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(2), CREB1(2), CREBBP(3), EP300(6), NCOA3(16), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), RXRA(1) 4570097 38 23 28 5 8 4 5 3 17 1 0.143 0.00592 0.104 36 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 59 BAK1(1), BFAR(2), BTK(1), CAD(6), CASP10(3), CASP3(2), CASP8(2), DAXX(3), DEDD(1), DIABLO(1), EGFR(2), EPHB2(4), FAF1(1), MAP2K4(5), MAP2K7(3), MAP3K1(3), MAP3K5(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(4), MAPK9(1), MET(4), NFAT5(4), NFKB2(1), NFKBIA(1), NFKBIB(1), NFKBIE(1), PTPN13(4), RALBP1(2), ROCK1(5), SMPD1(2), TP53(100), TPX2(2), TRAF2(1) 16463005 178 108 150 25 41 30 27 32 47 1 5.06e-06 0.00673 0.115 37 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 92 AKT1(1), AKT2(2), AKT3(2), CARD11(3), CBL(3), CBLB(2), CD3E(1), CD4(2), CD8B(2), CDC42(1), CDK4(2), CHUK(1), GRAP2(2), HRAS(1), IKBKB(4), ITK(1), KRAS(126), LCK(1), LCP2(3), MALT1(4), NCK1(4), NCK2(2), NFAT5(4), NFATC1(4), NFATC2(3), NFATC3(2), NFATC4(5), NFKB2(1), NFKBIA(1), NFKBIB(1), NFKBIE(1), PAK2(2), PAK4(1), PAK6(1), PAK7(2), PDCD1(1), PDK1(1), PIK3CA(4), PIK3CB(1), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PLCG1(1), PPP3CA(2), PPP3CC(1), PPP3R1(1), PRKCQ(2), PTPN6(4), PTPRC(2), RASGRP1(2), RHOA(1), SOS1(2), SOS2(1), TEC(2), VAV1(4), ZAP70(6) 22579789 248 128 124 37 35 88 76 26 21 2 2.27e-09 0.0138 0.230 38 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 85 ABL1(5), ABL2(1), AKT1(1), AKT2(2), AKT3(2), ARAF(2), BAD(1), BRAF(3), CAMK2D(1), CBL(3), CBLB(2), CRK(1), CRKL(1), EGF(5), EGFR(2), ELK1(2), ERBB2(6), ERBB3(4), ERBB4(6), GSK3B(2), HRAS(1), KRAS(126), MAP2K4(5), MAP2K7(3), MAPK8(2), MAPK9(1), NCK1(4), NCK2(2), NRG1(2), NRG2(1), PAK2(2), PAK4(1), PAK6(1), PAK7(2), PIK3CA(4), PIK3CB(1), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PLCG1(1), PLCG2(7), PRKCG(2), PTK2(3), RPS6KB2(1), SHC1(1), SHC2(2), SHC4(1), SOS1(2), SOS2(1), SRC(2), STAT5A(1) 23007042 246 128 123 34 36 80 82 25 22 1 6.39e-10 0.0188 0.305 39 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 ARAF(2), BRAF(3), CACNA1A(8), CRHR1(1), GNA11(2), GNAI1(1), GNAI2(1), GNAO1(2), GNAQ(1), GNAS(12), GNAZ(1), GRIA1(1), GRIA3(2), GRID2(8), GRM1(9), GRM5(7), GUCY1A3(2), GUCY1B3(2), GUCY2C(4), GUCY2D(1), GUCY2F(3), HRAS(1), IGF1R(6), ITPR1(10), ITPR2(4), ITPR3(8), KRAS(126), NOS1(7), NOS3(8), NPR1(1), NPR2(2), PLA2G1B(1), PLA2G3(1), PLA2G6(4), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), PPP2CA(1), PPP2R1A(4), PPP2R1B(3), PPP2R2A(2), PPP2R2B(2), PRKCG(2), PRKG1(1), PRKG2(1), RYR1(23) 24729363 302 132 175 44 73 73 100 33 23 0 2.45e-11 0.0246 0.385 40 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(4), ADRB2(1), CFTR(7), GNAS(12), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), SLC9A3R1(1) 2957408 33 18 25 3 15 6 4 4 4 0 0.0101 0.0250 0.385 41 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD3E(1), TGFB1(1), TGFBR1(8), TGFBR2(10) 2344836 20 14 20 4 5 3 2 3 7 0 0.272 0.0365 0.549 42 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 ASAH1(1), BFAR(2), BRAF(3), CAMP(2), CREB1(2), CREB5(1), SNX13(5), SRC(2), TERF2IP(1) 2499222 19 10 19 1 2 2 4 4 7 0 0.0801 0.0476 0.698 43 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 99 ADCY1(4), ADCY2(2), ADCY3(6), ADCY4(1), ADCY5(5), ADCY6(3), ADCY7(2), ADCY8(4), ADCY9(4), CALML3(1), CAMK2D(1), CREB1(2), CREB3L1(1), CREB3L2(2), CREB3L3(1), CREBBP(3), CTNNB1(7), DCT(2), DVL1(4), DVL2(4), DVL3(1), EDN1(1), EDNRB(2), EP300(6), FZD1(5), FZD10(4), FZD2(2), FZD3(3), FZD7(2), FZD8(1), FZD9(2), GNAI1(1), GNAI2(1), GNAO1(2), GNAQ(1), GNAS(12), GSK3B(2), HRAS(1), KIT(4), KRAS(126), LEF1(2), MITF(3), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), POMC(1), PRKACB(1), PRKACG(3), PRKCG(2), TCF7(1), TCF7L1(4), TCF7L2(1), TYR(4), TYRP1(1), WNT1(1), WNT10A(1), WNT11(1), WNT2(3), WNT2B(3), WNT3A(4), WNT5A(5), WNT6(1), WNT7A(2), WNT7B(2), WNT8A(2) 24649361 297 131 168 60 77 83 86 31 19 1 2.91e-09 0.0499 0.714 44 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 126 ARAF(2), BRAF(3), CASP3(2), FASLG(1), HLA-A(2), HLA-G(2), HRAS(1), ICAM1(2), IFNA10(1), IFNA16(1), IFNA7(2), IFNAR1(2), IFNAR2(2), IFNGR1(2), ITGAL(2), ITGB2(1), KIR2DL3(2), KIR3DL1(2), KLRC3(2), KRAS(126), LCK(1), LCP2(3), NCR1(1), NFAT5(4), NFATC1(4), NFATC2(3), NFATC3(2), NFATC4(5), PIK3CA(4), PIK3CB(1), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PLCG1(1), PLCG2(7), PPP3CA(2), PPP3CC(1), PPP3R1(1), PRF1(1), PRKCG(2), PTPN6(4), RAC2(1), SHC1(1), SHC2(2), SHC4(1), SOS1(2), SOS2(1), SYK(2), TNFRSF10A(2), TNFRSF10B(2), VAV1(4), ZAP70(6) 25297910 243 128 119 43 36 81 77 27 21 1 1.24e-07 0.0525 0.735 45 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(4), FHL5(1), FSHB(1), FSHR(3), GNAS(12), XPO1(2) 2159135 23 14 18 2 12 2 4 3 2 0 0.0709 0.0586 0.802 46 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 110 ABL1(5), ANAPC1(5), ANAPC2(4), ANAPC4(3), ANAPC5(5), ANAPC7(1), ATM(10), ATR(9), BUB1(3), BUB3(1), CCNA1(3), CCNA2(3), CCNB1(1), CCNB2(2), CCNB3(1), CCND2(3), CCND3(1), CCNE1(1), CCNE2(1), CDC14A(2), CDC14B(1), CDC16(1), CDC23(1), CDC25A(1), CDC25B(1), CDC27(7), CDC6(1), CDC7(2), CDK4(2), CDK6(2), CDK7(1), CDKN2A(31), CREBBP(3), CUL1(2), E2F3(2), EP300(6), ESPL1(4), GSK3B(2), MAD1L1(1), MAD2L1(1), MCM2(6), MCM3(4), MCM5(2), MCM6(5), MCM7(1), MDM2(2), PKMYT1(2), PRKDC(7), RB1(3), RBL1(2), RBL2(6), SKP1(1), SKP2(3), SMAD2(1), SMAD4(32), SMC1A(2), SMC1B(3), TFDP1(1), TGFB1(1), TP53(100), YWHAE(2), YWHAG(1), YWHAH(1) 30324667 324 127 278 33 66 48 49 51 109 1 1.65e-11 0.0958 1.000 47 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(1), GNAS(12), GNB1(3), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1) 2195611 24 13 19 2 14 4 3 2 1 0 0.0212 0.123 1.000 48 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(3), RAB11A(1), RAB27A(2), RAB3A(1), RAB4A(2), RAB6A(1), RAB9A(1) 941380 11 5 11 1 5 3 1 1 1 0 0.0815 0.133 1.000 49 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY1(4), ADCY2(2), ADCY3(6), ADCY4(1), ADCY5(5), ADCY6(3), ADCY7(2), ADCY8(4), ADCY9(4), AKAP10(2), AKAP11(3), AKAP12(6), AKAP2(5), AKAP3(2), AKAP4(1), AKAP6(5), AKAP7(2), AKAP9(7), ARHGEF1(2), CHMP1B(1), GNA11(2), GNA14(1), GNA15(3), GNAI2(1), GNAL(2), GNAO1(2), GNAQ(1), GNAZ(1), GNB1(3), GNB2(1), GNB3(2), GNB5(1), HRAS(1), ITPR1(10), KRAS(126), PDE1B(1), PDE1C(1), PDE4A(1), PDE4C(2), PDE4D(2), PDE7B(1), PDE8A(2), PDE8B(3), PLCB3(4), PPP3CA(2), PPP3CC(1), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PRKCD(4), PRKCE(1), PRKCG(2), PRKCH(1), PRKCI(4), PRKCQ(2), PRKD3(4), RHOA(1), RRAS(2), USP5(2) 26044372 275 131 152 59 53 87 91 30 12 2 1.61e-06 0.166 1.000 50 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(1), GNAQ(1), GNB1(3), HTR2C(5), PLCB1(1), TUB(2) 1571371 13 9 13 2 4 3 0 4 2 0 0.196 0.171 1.000 51 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 92 ADCY1(4), ADCY2(2), ADCY3(6), ADCY4(1), ADCY5(5), ADCY6(3), ADCY7(2), ADCY8(4), ADCY9(4), CSNK1D(1), DRD1(5), EGF(5), EGFR(2), GJA1(1), GNA11(2), GNAI1(1), GNAI2(1), GNAQ(1), GNAS(12), GRM1(9), GRM5(7), GUCY1A3(2), GUCY1B3(2), GUCY2C(4), GUCY2D(1), GUCY2F(3), HRAS(1), HTR2A(3), HTR2B(1), HTR2C(5), ITPR1(10), ITPR2(4), ITPR3(8), KRAS(126), MAP3K2(2), MAPK7(4), NPR1(1), NPR2(2), PDGFC(2), PDGFRA(3), PDGFRB(3), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), PRKACB(1), PRKACG(3), PRKCG(2), PRKG1(1), PRKG2(1), SOS1(2), SOS2(1), SRC(2), TJP1(6), TUBA1A(2), TUBA1B(1), TUBA3C(3), TUBA3D(3), TUBA3E(4), TUBA8(4), TUBAL3(1), TUBB1(3), TUBB2B(1), TUBB3(2), TUBB6(1), TUBB8(2) 29541835 322 133 194 53 79 93 94 34 22 0 5.66e-12 0.175 1.000 52 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(11), C5(2), C6(6), C7(4), C8A(4), C9(2) 2775102 29 12 29 6 7 7 4 4 7 0 0.128 0.180 1.000 53 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT1(2), ACAT2(1), BDH1(1), BDH2(1), HMGCS2(2), OXCT1(2), OXCT2(1) 1598389 10 6 10 1 1 4 0 1 4 0 0.200 0.188 1.000 54 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 ADRB2(1), AKT1(1), ANXA1(3), GNAS(12), GNB1(3), NOS3(8), NR3C1(2), PIK3CA(4), PIK3R1(1), RELA(2), SYT1(2) 4041489 39 22 34 6 13 4 11 7 3 1 0.0967 0.189 1.000 55 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY1(4), ADCY2(2), ADCY3(6), ADCY4(1), ADCY5(5), ADCY6(3), ADCY7(2), ADCY8(4), ADCY9(4), CACNA1C(8), CACNA1D(10), CACNA1F(4), CACNA1S(5), CALML3(1), CAMK2D(1), CDC42(1), CGA(1), EGFR(2), ELK1(2), FSHB(1), GNA11(2), GNAQ(1), GNAS(12), GNRH1(1), GNRH2(1), GNRHR(1), HRAS(1), ITPR1(10), ITPR2(4), ITPR3(8), KRAS(126), MAP2K3(1), MAP2K4(5), MAP2K6(3), MAP2K7(3), MAP3K1(3), MAP3K2(2), MAP3K4(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK7(4), MAPK8(2), MAPK9(1), MMP14(2), MMP2(2), PLA2G1B(1), PLA2G3(1), PLA2G6(4), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), PLD2(4), PRKACB(1), PRKACG(3), PRKCD(4), SOS1(2), SOS2(1), SRC(2) 28702594 301 132 172 51 62 85 96 31 24 3 1.44e-10 0.200 1.000 56 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(4), GNAS(12), GNB1(3), PRKAR1A(1) 1510477 20 12 15 3 11 4 2 2 1 0 0.118 0.262 1.000 57 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 13 AKT1(1), CAT(1), GHR(2), HRAS(1), IGF1R(6), PIK3CA(4), PIK3R1(1), SHC1(1) 2936435 17 10 17 3 5 2 2 4 3 1 0.211 0.274 1.000 58 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(1), CHRNA1(4) 710771 5 4 5 1 3 0 0 0 2 0 0.520 0.280 1.000 59 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 TGDS(1), UGDH(2), UGP2(3), UXS1(2) 1090157 8 6 8 2 0 2 1 4 1 0 0.605 0.303 1.000 60 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(4), F5(8), FGA(4), FGB(4), FGG(2), PROC(1), PROS1(2), SERPINC1(3), TFPI(2) 3603289 30 12 29 9 3 6 14 5 2 0 0.501 0.317 1.000 61 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT1(2), ACAT2(1), OXCT1(2) 740133 5 3 5 0 0 3 0 0 2 0 0.324 0.322 1.000 62 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 PARK2(3), SNCAIP(5), UBE2F(1), UBE2G2(1) 1408791 10 5 10 1 4 1 3 1 1 0 0.127 0.329 1.000 63 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C9(2) 440347 2 2 2 0 1 1 0 0 0 0 0.477 0.334 1.000 64 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 ACAT1(2), CSF1(2), IL6(1), LDLR(1), LPL(3) 1165731 9 4 9 0 3 3 1 1 1 0 0.0288 0.337 1.000 65 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREB1(2), OPRK1(2), POLR2A(5), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1) 2859762 17 10 17 2 10 1 3 1 2 0 0.0627 0.340 1.000 66 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 12 ADCY1(4), ADRB2(1), GNAS(12), PLCE1(5), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), RAP2B(2) 3366506 32 16 27 4 16 3 5 6 2 0 0.0313 0.358 1.000 67 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 AKT1(1), BAD(1), MUSK(6), PIK3CA(4), PIK3R1(1), PTK2(3), SRC(2), TERT(5), YWHAH(1) 3679200 24 11 23 3 5 7 2 6 4 0 0.0226 0.359 1.000 68 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CDK5R1(1), CSNK1D(1), DRD1(5), GRM1(9), PLCB1(1), PPP1CA(1), PPP1R1B(1), PPP2CA(1), PPP3CA(2), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1) 3547533 30 13 29 5 12 5 4 6 3 0 0.0471 0.367 1.000 69 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(1), TPI1(3) 360199 4 2 4 0 2 1 0 1 0 0 0.236 0.373 1.000 70 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(7), CDH1(1), CREBBP(3), EP300(6), MAP3K7(2), SKIL(1), TGFB1(1), TGFBR1(8), TGFBR2(10) 5652822 39 20 39 7 11 5 7 7 9 0 0.125 0.376 1.000 71 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(4), GNAS(12), GNB1(3), PPP2CA(1), PRKAA1(2), PRKAA2(1), PRKAB1(1), PRKAB2(2), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1) 3459902 34 16 29 4 15 7 3 4 5 0 0.0145 0.387 1.000 72 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(1), HK1(4), HK2(6), HK3(4), PGM1(1), TGDS(1) 2259501 17 10 17 4 8 1 2 0 6 0 0.323 0.391 1.000 73 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(3), ARG1(1), GLS(1), OAT(2), PRODH(2) 1250874 9 4 9 1 3 1 2 1 2 0 0.224 0.395 1.000 74 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(8), PRKACB(1), PRKACG(3), PRKAR2B(1) 2228145 13 8 12 4 2 2 2 2 4 1 0.781 0.400 1.000 75 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CHUK(1), CREBBP(3), EP300(6), IKBKB(4), IL1B(1), MAP2K3(1), MAP2K6(3), MAP3K7(2), MAPK11(1), NFKBIA(1), NR3C1(2), RELA(2), TGFBR1(8), TGFBR2(10), TLR2(3) 6614651 48 22 48 8 11 8 8 6 15 0 0.0454 0.401 1.000 76 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 AKT1(1), BAD(1), CASP9(1), CHUK(1), GHR(2), NFKBIA(1), PIK3CA(4), PIK3R1(1), PPP2CA(1), RELA(2), YWHAH(1) 3139179 16 8 16 4 1 3 4 4 3 1 0.512 0.413 1.000 77 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 B3GALT1(1), B3GALT2(2), B3GNT5(1), FUT2(2), ST3GAL4(2) 1595902 8 5 8 1 6 0 0 2 0 0 0.205 0.414 1.000 78 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(2), ENO1(3), GPI(3), HK1(4), PFKL(2), PGAM1(2), PGK1(3), PKLR(2), TPI1(3) 2059677 24 11 24 6 10 8 1 2 3 0 0.0958 0.423 1.000 79 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(2), CAMK1G(2), HDAC9(6), MEF2A(1), MEF2C(3), MEF2D(2), YWHAH(1) 1769598 17 9 17 2 3 3 7 1 3 0 0.126 0.429 1.000 80 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNGR1(2), JAK1(1), JAK2(6), STAT1(3) 1798166 12 8 11 3 2 0 3 2 5 0 0.728 0.443 1.000 81 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD3E(1), CD80(2), CD86(6), ITK(1), LCK(1), PIK3CA(4), PIK3R1(1) 2800525 16 11 14 4 4 1 2 3 5 1 0.529 0.447 1.000 82 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3E(1) 250022 1 1 1 0 0 0 0 0 1 0 0.843 0.460 1.000 83 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 HADH(1), HADHA(1), HADHB(2), HSD17B4(3), MECR(2), PPT1(1), PPT2(2) 1876036 12 5 12 0 3 3 1 2 3 0 0.0205 0.462 1.000 84 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(1), RDH5(1) 849793 2 2 2 0 1 0 1 0 0 0 0.544 0.465 1.000 85 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(2), GPD2(1), NDUFA1(1), SDHA(3) 1455457 7 4 7 1 4 0 1 1 1 0 0.309 0.478 1.000 86 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 TGDS(1), UGDH(2), UXS1(2) 861396 5 4 5 2 0 1 1 2 1 0 0.837 0.500 1.000 87 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 BPNT1(2), PAPSS1(2), PAPSS2(6), SULT1A2(1), SULT2A1(1), SUOX(1) 1332992 13 4 12 2 1 2 1 4 5 0 0.375 0.501 1.000 88 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(1), ALDOB(2), TPI1(3) 852697 6 3 6 1 3 2 0 1 0 0 0.295 0.506 1.000 89 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RANBP1(1), RANBP2(6), RANGAP1(2) 1848692 9 4 9 0 1 3 2 1 1 1 0.0700 0.507 1.000 90 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 AKT1(1), CREB1(2), HRAS(1), MAPK7(4), MEF2A(1), MEF2C(3), MEF2D(2), NTRK1(2), PIK3CA(4), PIK3R1(1), PLCG1(1), SHC1(1) 4232061 23 13 23 2 5 6 5 3 4 0 0.0263 0.514 1.000 91 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 AOC2(2), AOC3(3), CES1(2), ESD(1) 1324270 8 4 8 1 3 2 3 0 0 0 0.201 0.521 1.000 92 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 CREB1(2), HRAS(1), SHC1(1), SOS1(2), SRC(2) 1950891 8 5 8 2 2 3 0 1 2 0 0.432 0.523 1.000 93 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(3), CAPN1(1), CAPNS1(2), CAPNS2(2), CDK5R1(1), CSNK1D(1), GSK3B(2), MAPT(3), PPP2CA(1) 2109465 16 8 16 3 7 5 1 2 1 0 0.0950 0.526 1.000 94 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 AKR1A1(1), EHHADH(1), HADHA(1) 1067768 3 3 3 1 1 0 1 0 1 0 0.656 0.528 1.000 95 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 LDLR(1), NR1H3(3), NR1H4(1), RXRA(1) 1195014 6 4 6 1 2 3 1 0 0 0 0.194 0.529 1.000 96 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 CASP3(2), CASP8(2), CFLAR(3) 850719 7 4 7 3 1 0 1 1 4 0 0.841 0.531 1.000 97 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 PGLYRP2(2) 408159 2 2 2 0 1 0 0 1 0 0 0.564 0.546 1.000 98 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ARPC1A(1), ARPC2(1), CDC42(1), PDGFRA(3), PIK3CA(4), PIK3R1(1), WASL(2) 2932865 13 7 13 2 2 4 2 4 1 0 0.216 0.549 1.000 99 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(8), BMPR1A(3), BMPR2(3) 1377092 14 6 14 3 4 6 2 1 1 0 0.244 0.552 1.000 100 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(1), GLUD2(3) 1009220 4 3 4 2 2 1 1 0 0 0 0.787 0.559 1.000 101 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 DCN(1), KERA(2), LUM(2) 794878 5 2 5 1 1 0 1 3 0 0 0.543 0.562 1.000 102 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(3), EPHA4(3), EPHB1(2), ITGA1(7), L1CAM(5), RAP1B(3), SELP(2) 3454840 25 14 23 4 11 5 2 3 4 0 0.0571 0.569 1.000 103 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(2), ACADM(1), ACADS(1), ACSL1(1), ACSL3(4), ACSL4(3), CPT1A(1), CPT2(1), EHHADH(1), HADHA(1), SCP2(1) 3710199 17 8 17 1 5 4 4 2 2 0 0.0221 0.581 1.000 104 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(2), ACADM(1), ACADS(1), ACAT1(2), HADHA(1) 1197175 7 3 7 0 1 4 1 1 0 0 0.0988 0.584 1.000 105 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 FH(3), IDH2(5), OGDH(5), SDHA(3), SUCLA2(1) 2063701 17 8 17 4 3 3 5 4 2 0 0.315 0.588 1.000 106 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(2) 158041 2 1 2 0 2 0 0 0 0 0 0.511 0.599 1.000 107 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CCNE1(1), CDC34(1), CUL1(2), FBXW7(5), RB1(3), TFDP1(1) 1851788 13 6 13 6 2 2 2 3 4 0 0.882 0.601 1.000 108 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(3), ADCY1(4), CCNB1(1), GNAI1(1), GNAS(12), GNB1(3), HRAS(1), MYT1(11), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), SRC(2) 4619824 46 19 41 7 21 11 5 7 2 0 0.00519 0.611 1.000 109 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(1), CLOCK(3), CRY1(1), CRY2(1), CSNK1E(1), PER1(3) 1917567 10 4 10 1 2 1 0 3 3 1 0.206 0.625 1.000 110 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 CDC34(1), NRF1(3), UBE2D1(1), UBE2E1(1), UBE2E3(2), UBE2G2(1), UBE2J1(1), UBE2J2(2), UBE2S(1), UBE3A(4) 2329050 17 6 16 1 8 4 4 1 0 0 0.0122 0.626 1.000 111 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 ADCY1(4), AKT1(1), BAD(1), CSF2RB(2), IGF1R(6), IL3RA(2), KIT(4), PIK3CA(4), PIK3R1(1), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), YWHAH(1) 4850819 34 13 34 6 12 6 4 8 4 0 0.0279 0.629 1.000 112 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(4), GBA(3), LPO(5), MPO(2), TPO(7) 1861565 21 10 21 5 11 1 4 2 3 0 0.179 0.632 1.000 113 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CCNB1(1), CDC25A(1), CDC25B(1), CSK(1), PTPRA(1), SRC(2) 2029853 7 7 7 2 2 2 2 0 1 0 0.561 0.641 1.000 114 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD4(2), CSF1(2), EPO(2), IL6(1), IL7(1), IL9(1) 1360857 9 3 9 1 1 1 2 4 1 0 0.291 0.642 1.000 115 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 ABAT(2), ACADS(1), ACAT1(2), ACAT2(1), ALDH1A1(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(1), ALDH5A1(2), EHHADH(1), GAD1(5), GAD2(7), HADHA(1), L2HGDH(2), OXCT1(2), PDHA1(2), PDHA2(2) 5694611 35 16 35 6 9 8 7 3 7 1 0.0554 0.650 1.000 116 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CAMK1(2), CAMK1G(2), CAMK2D(1), CAMK4(1), CREB1(2), SYT1(2) 2582620 10 6 10 0 2 0 2 0 5 1 0.122 0.654 1.000 117 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(2), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2), ST3GAL5(1), ST6GALNAC2(1), ST6GALNAC4(1), ST8SIA1(2) 1239594 12 4 12 2 5 2 3 0 2 0 0.122 0.662 1.000 118 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(3), ADH1B(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(4) 1231575 14 3 14 4 5 3 1 2 3 0 0.424 0.668 1.000 119 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(3), GALNT10(5), GALNT2(2), GALNT6(2), GALNT7(2), GALNT8(1), GALNT9(1), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2), WBSCR17(2) 3157017 23 11 22 7 11 3 6 2 1 0 0.381 0.673 1.000 120 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CSF1(2), IL1B(1), MST1R(7) 1441687 10 7 10 3 2 3 0 2 3 0 0.431 0.680 1.000 121 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 AKR1B1(1), GUSB(1), RPE(2), UGDH(2), UGP2(3), UGT1A1(1), UGT1A10(2), UGT1A4(2), UGT1A6(2), UGT1A7(1), UGT2A3(1), UGT2B10(4), UGT2B15(2), UGT2B17(1), UGT2B28(3), UGT2B4(1), XYLB(1) 5955820 30 14 29 3 4 9 4 9 4 0 0.0206 0.681 1.000 122 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 JUND(1), PPP1R1B(1) 853705 2 2 2 0 0 0 0 1 1 0 0.809 0.687 1.000 123 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA2(1), IL4R(3), JAK1(1), JAK2(6), TYK2(2) 2307327 13 8 12 3 2 0 3 1 7 0 0.777 0.697 1.000 124 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA2(1), IL4R(3), JAK1(1), JAK2(6), TYK2(2) 2307327 13 8 12 3 2 0 3 1 7 0 0.777 0.697 1.000 125 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 CSNK2A1(1), ELK1(2), HRAS(1), IGF1R(6), IRS1(4), MAPK8(2), PIK3CA(4), PIK3R1(1), RASA1(2), SHC1(1), SOS1(2), SRF(1) 5482417 27 16 27 6 7 4 1 7 8 0 0.241 0.699 1.000 126 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(3), ARHGAP5(5), CASP1(1), CASP10(3), CASP3(2), CASP8(2), CASP9(1), PRF1(1) 2835077 18 8 18 4 3 4 1 3 7 0 0.365 0.703 1.000 127 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(1), ASL(2), CPS1(4), GLS(1), GOT1(2) 1715149 10 3 10 0 3 2 1 3 0 1 0.0525 0.706 1.000 128 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 ADCY1(4), AKT1(1), CAMK2D(1), CREB1(2), GNAS(12), HRAS(1), PIK3CA(4), PIK3R1(1), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), RPS6KA5(2), SOS1(2) 6512921 38 19 33 6 16 6 5 7 4 0 0.0401 0.709 1.000 129 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 A4GALT(1), FUT2(2), FUT9(1), GBGT1(1), HEXA(2), HEXB(2), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2), ST8SIA1(2) 2240350 16 6 16 1 8 3 3 0 2 0 0.0199 0.711 1.000 130 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(2), AGT(1), BDKRB2(1), KNG1(1), NOS3(8), REN(3) 2224391 16 6 16 2 7 2 6 1 0 0 0.0615 0.711 1.000 131 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ASPH(2), CREB1(2), EDN1(1), EP300(6), EPO(2), HIF1A(1), NOS3(8) 3772883 22 9 22 2 7 2 6 2 5 0 0.0491 0.715 1.000 132 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(1), CDC25B(1), CDK7(1) 1571987 3 3 3 1 1 0 1 0 1 0 0.737 0.717 1.000 133 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 HGD(2) 491313 2 1 2 2 0 0 0 1 1 0 0.934 0.721 1.000 134 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR2(1), GPR161(1), GPR171(2), GPR18(1), GPR34(1), GPR39(4), GPR65(2), GPR75(1) 2172757 13 8 13 3 2 5 1 4 1 0 0.208 0.728 1.000 135 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(4), CD3E(1), CD4(2), CREBBP(3), CSK(1), GNAS(12), GNB1(3), LCK(1), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PTPRC(2), ZAP70(6) 5181404 43 19 38 6 20 8 6 5 4 0 0.00610 0.729 1.000 136 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(4), CD3E(1), CD4(2), CREBBP(3), CSK(1), GNAS(12), GNB1(3), LCK(1), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PTPRC(2), ZAP70(6) 5181404 43 19 38 6 20 8 6 5 4 0 0.00610 0.729 1.000 137 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(2), FH(3), IDH1(1), IDH2(5), SUCLA2(1) 1950002 12 6 12 2 1 3 5 2 1 0 0.334 0.732 1.000 138 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 AKT1(1), BAD(1), HRAS(1), IGF1R(6), IRS1(4), PIK3CA(4), PIK3R1(1), SHC1(1), SOS1(2), YWHAH(1) 4161313 22 13 22 5 7 4 1 6 4 0 0.234 0.735 1.000 139 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD4(2), CD80(2) 872277 4 2 4 1 0 0 1 1 1 1 0.845 0.740 1.000 140 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD4(2) 522538 2 1 2 1 0 0 0 1 1 0 0.905 0.746 1.000 141 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(3), ARPC1A(1), ARPC2(1), NCK1(4), NCKAP1(5), NTRK1(2), PIR(2), WASF1(1), WASF2(1), WASF3(1), WASL(2) 3375482 23 8 23 4 8 6 2 4 3 0 0.128 0.756 1.000 142 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD86(6), IFNGR1(2), IL12B(1), IL4R(3) 2787125 12 9 10 4 3 1 2 2 4 0 0.583 0.757 1.000 143 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 EGFR(2), ELK1(2), GNAS(12), GNB1(3), HRAS(1), IGF1R(6), KLK2(1), MKNK2(1), NGFR(1), PDGFRA(3), PPP2CA(1), RPS6KA5(2), SHC1(1), SOS1(2), SRC(2), STAT3(2) 7429605 42 23 37 9 16 11 4 5 6 0 0.0615 0.757 1.000 144 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(6), APOA4(3), APOE(1), CYP7A1(2), DGAT1(3), HMGCR(5), LDLR(1), LPL(3), LRP1(15), SCARB1(1), SOAT1(1) 6038956 41 20 41 8 17 10 4 3 6 1 0.0150 0.758 1.000 145 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(10), CDC25A(1), CDC25B(1), MYT1(11), YWHAH(1) 3027886 24 10 24 4 7 4 4 5 4 0 0.154 0.759 1.000 146 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 CREB1(2), KEAP1(2), MAFF(2), MAPK8(2) 1996057 8 4 8 1 2 0 1 2 3 0 0.367 0.760 1.000 147 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDFT1(2), FDPS(1), IDI1(1), SQLE(2) 718525 6 4 5 3 2 2 1 0 1 0 0.727 0.762 1.000 148 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(2), HLCS(4), SPCS1(1) 680580 7 3 7 2 1 1 2 3 0 0 0.638 0.766 1.000 149 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA1(1), NDUFA10(2), NDUFA11(1), NDUFA8(1), NDUFS1(1), NDUFV1(1), NDUFV2(3) 1543166 10 5 9 3 3 4 0 2 1 0 0.517 0.772 1.000 150 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(3), APOBEC3B(2), APOBEC3G(1) 1607383 6 3 6 1 3 2 0 1 0 0 0.313 0.776 1.000 151 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(1), COASY(1), DPYD(4), DPYS(3), ENPP3(3), PANK2(1), PANK3(1), PANK4(1), UPB1(2) 3114674 17 8 17 4 5 6 3 2 1 0 0.176 0.778 1.000 152 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(1), ABAT(2), ADSL(2), ADSS(1), AGXT(2), AGXT2(1), ASL(2), ASNS(3), ASPA(1), CAD(6), DARS(1), DDO(2), GAD1(5), GAD2(7), GOT1(2), GPT(1), GPT2(2), PC(3) 5767932 44 17 44 10 12 9 11 6 5 1 0.100 0.782 1.000 153 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(3), ARPC1A(1), ARPC2(1), CDC42(1), WASF1(1), WASL(2) 1782887 9 4 9 3 2 4 1 2 0 0 0.496 0.796 1.000 154 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(4), CREB1(2), ELK1(2), GNAI1(1), GNAQ(1), GNAS(12), GNB1(3), HRAS(1), NFATC1(4), NFATC2(3), NFATC3(2), NFATC4(5), PLCG1(1), PPP3CA(2), PPP3CC(1), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), RPS6KA3(1), SYT1(2) 7836018 55 23 50 9 21 13 4 7 9 1 0.00843 0.799 1.000 155 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 AKT1(1), HRAS(1), KLK2(1), NTRK1(2), PIK3CA(4), PIK3R1(1), PLCG1(1), SHC1(1), SOS1(2) 3445214 14 8 14 3 4 3 2 4 1 0 0.316 0.800 1.000 156 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(1), F13B(2), HSD17B1(1), HSD17B2(2), HSD17B4(3), HSD3B1(2) 1791234 11 3 11 4 1 5 2 2 1 0 0.505 0.807 1.000 157 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 EPHX2(1), HSD3B7(3), RDH11(2) 1069849 6 2 6 0 1 0 2 2 1 0 0.192 0.811 1.000 158 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 APC(7), AXIN1(3), BMP10(1), BMP2(1), BMP4(2), BMP5(2), BMP7(1), BMPR1A(3), BMPR2(3), CHRD(2), CTNNB1(7), DVL1(4), FZD1(5), GATA4(1), GSK3B(2), MAP3K7(2), MEF2C(3), NKX2-5(1), RFC1(3), TGFB1(1), TGFBR1(8), TGFBR2(10), WNT1(1) 8138527 73 27 73 8 24 15 10 16 8 0 0.000204 0.812 1.000 159 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(2), BAIAP2(3), CASP1(1), CASP3(2), CASP7(1), CASP8(2), INSR(4), ITCH(2), MAGI1(2), MAGI2(10), RERE(6), WWP1(2), WWP2(5) 5321058 42 18 41 9 14 8 5 5 10 0 0.0852 0.815 1.000 160 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(4), ICAM1(2), ITGAL(2), ITGAM(4), ITGB2(1), SELE(2), SELL(1) 2321608 16 7 15 4 4 2 1 3 6 0 0.325 0.819 1.000 161 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 CSNK2A1(1), ELK1(2), HRAS(1), INSR(4), IRS1(4), MAPK8(2), PIK3CA(4), PIK3R1(1), RASA1(2), SHC1(1), SOS1(2), SRF(1) 5647326 25 14 25 5 7 4 1 7 6 0 0.182 0.820 1.000 162 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT1(2), ACAT2(1), EHHADH(1), GCDH(2), HADHA(1) 1718262 7 3 7 1 1 2 2 0 2 0 0.344 0.821 1.000 163 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOSL1(1), FOSL2(3), IFNAR1(2), IFNAR2(2), MAPK8(2), RELA(2), TNFRSF11A(2), TRAF6(1) 2463556 15 6 15 4 1 3 3 5 3 0 0.507 0.826 1.000 164 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CD3E(1), CD4(2) 705764 3 1 3 1 0 0 0 1 2 0 0.839 0.827 1.000 165 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 CYP11A1(1), CYP11B1(4), CYP11B2(1), CYP17A1(1), CYP21A2(1), HSD11B1(1), HSD3B1(2) 2118689 11 7 11 4 5 2 2 2 0 0 0.484 0.829 1.000 166 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 CYP11A1(1), CYP11B1(4), CYP11B2(1), CYP17A1(1), CYP21A2(1), HSD11B1(1), HSD3B1(2) 2118689 11 7 11 4 5 2 2 2 0 0 0.484 0.829 1.000 167 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 ADAM17(4), DLL1(2), FURIN(2), NOTCH1(9), PSEN1(1) 2155455 18 7 18 7 7 7 1 1 2 0 0.296 0.830 1.000 168 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(2), FH(3), IDH1(1), IDH2(5), IDH3A(2), IDH3G(2), PC(3), PCK1(3), SDHA(3), SUCLA2(1), SUCLG1(3) 4541351 28 11 28 5 5 6 11 5 1 0 0.111 0.831 1.000 169 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(4), CPT1A(1), LEPR(7), PRKAA1(2), PRKAA2(1), PRKAB1(1), PRKAB2(2) 3177090 18 7 18 3 2 6 1 2 7 0 0.186 0.834 1.000 170 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(1), GOT1(2), TAT(1), TYR(4) 1028874 8 3 8 3 2 1 3 2 0 0 0.742 0.836 1.000 171 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(1), ACAT1(2), ACAT2(1), EHHADH(1), HADHA(1), HADHB(2) 1837249 8 3 8 1 0 3 1 0 4 0 0.288 0.836 1.000 172 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDFT1(2), FDPS(1), IDI1(1), SQLE(2) 954083 6 4 5 3 2 2 1 0 1 0 0.730 0.847 1.000 173 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 AKT1(1), PIK3CA(4), PIK3R1(1), PLCB1(1), PLCG1(1), VAV1(4) 2820243 12 5 12 4 2 3 1 4 1 1 0.612 0.847 1.000 174 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(5), EGFR(2), ERBB3(4), NRG1(2), UBE2D1(1) 2262250 14 5 14 2 1 3 5 3 2 0 0.253 0.848 1.000 175 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(5), ATIC(2), ATP6V0C(1), DHFR(1), GART(1), MTHFD1(2), MTHFD1L(1), MTHFD2(1), MTHFR(1), MTR(4), SHMT1(1), SHMT2(3), TYMS(1) 3939983 24 7 24 6 4 2 6 4 7 1 0.339 0.853 1.000 176 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 33 A1BG(2), AKT1(1), AKT2(2), AKT3(2), BAD(1), BTK(1), CDKN2A(31), DAPP1(2), GSK3A(1), GSK3B(2), IARS(4), INPP5D(1), PDK1(1), PIK3CA(4), RPS6KA2(2), RPS6KA3(1), SHC1(1), SOS1(2), SOS2(1), TEC(2), YWHAE(2), YWHAG(1), YWHAH(1) 8036930 68 42 56 11 8 13 5 11 31 0 0.0260 0.855 1.000 177 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(1), CSAD(1), GAD1(5), GAD2(7), GGT1(1) 1283495 15 7 15 7 4 3 4 1 2 1 0.763 0.856 1.000 178 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(3), ENO3(1), FARS2(1), GOT1(2), PAH(1), TAT(1) 1812558 9 5 9 2 3 2 2 2 0 0 0.426 0.857 1.000 179 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNB1(1), CDC25A(1), CDC25B(1), CDK7(1), XPO1(2) 1926510 6 5 6 2 2 0 1 0 3 0 0.741 0.863 1.000 180 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(1), LPL(3), NR3C1(2), PPARG(1), RXRA(1) 1273638 8 3 8 2 3 1 2 1 1 0 0.384 0.864 1.000 181 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 146 APC(7), APC2(2), AXIN1(3), AXIN2(1), BTRC(2), CAMK2D(1), CCND2(3), CCND3(1), CHD8(7), CREBBP(3), CSNK1A1L(4), CSNK1E(1), CSNK2A1(1), CTBP2(3), CTNNB1(7), CUL1(2), CXXC4(1), DAAM1(9), DAAM2(4), DKK2(1), DKK4(1), DVL1(4), DVL2(4), DVL3(1), EP300(6), FBXW11(1), FOSL1(1), FZD1(5), FZD10(4), FZD2(2), FZD3(3), FZD7(2), FZD8(1), FZD9(2), GSK3B(2), LEF1(2), LRP5(7), LRP6(5), MAP3K7(2), MAPK8(2), MAPK9(1), MMP7(1), NFAT5(4), NFATC1(4), NFATC2(3), NFATC3(2), NFATC4(5), NKD1(4), NLK(2), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), PPARD(1), PPP2CA(1), PPP2R1A(4), PPP2R1B(3), PPP2R2A(2), PPP2R2B(2), PPP3CA(2), PPP3CC(1), PPP3R1(1), PRICKLE1(2), PRICKLE2(2), PRKACB(1), PRKACG(3), PRKCG(2), PSEN1(1), RAC2(1), RHOA(1), ROCK1(5), ROCK2(2), SENP2(1), SFRP1(2), SFRP4(1), SKP1(1), SMAD2(1), SMAD4(32), SOX17(1), TCF7(1), TCF7L1(4), TCF7L2(1), TP53(100), VANGL1(1), WIF1(2), WNT1(1), WNT10A(1), WNT11(1), WNT2(3), WNT2B(3), WNT3A(4), WNT5A(5), WNT6(1), WNT7A(2), WNT7B(2), WNT8A(2) 36519302 367 131 333 68 111 61 47 68 79 1 5.52e-09 0.864 1.000 182 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(2), AASS(2), KARS(1) 1035708 5 2 5 3 0 0 1 1 3 0 0.979 0.866 1.000 183 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 AKR1A1(1), EHHADH(1), HADH(1), HADHA(1), HSD17B4(3), SIRT1(1) 2615365 8 4 8 0 3 1 1 2 1 0 0.0736 0.871 1.000 184 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 BPNT1(2), CHST11(2), CHST12(1), PAPSS1(2), PAPSS2(6), SULT1A2(1), SULT2A1(1), SULT2B1(1), SUOX(1) 2070556 17 8 16 3 4 2 2 4 5 0 0.289 0.881 1.000 185 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CD80(2), CR1(4), CR2(5), FCGR2B(2), ICAM1(2), ITGAL(2), ITGB2(1), PTPRC(2) 3342277 20 11 20 7 5 5 1 5 3 1 0.489 0.881 1.000 186 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(1), CLOCK(3), CRY1(1), CRY2(1), CSNK1D(1), CSNK1E(1), NPAS2(4), PER1(3), PER2(5), PER3(2) 3812027 22 9 21 3 3 6 3 5 4 1 0.0509 0.882 1.000 187 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(2), AFMID(2), GRHPR(1), HAO1(1), HAO2(1), MTHFD1(2), MTHFD1L(1), MTHFD2(1) 2938045 11 5 11 1 3 3 1 0 3 1 0.127 0.883 1.000 188 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(3), CHAT(4), PCYT1A(2), PDHA1(2), PDHA2(2), SLC18A3(3) 1572002 16 10 16 8 5 3 5 1 2 0 0.703 0.883 1.000 189 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOB(2), FBP2(1), GOT1(2), GPT(1), GPT2(2), ME1(2), ME2(6), ME3(1), PGK1(3), PKLR(2), RPE(2), RPIA(1), TKT(1), TPI1(3) 3994140 29 9 29 3 4 10 8 3 4 0 0.00709 0.883 1.000 190 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 49 AKT1(1), AKT2(2), AKT3(2), BRD4(5), CBL(3), CDC42(1), CDKN2A(31), F2RL2(2), FLOT2(1), GSK3A(1), GSK3B(2), INPPL1(2), IRS1(4), IRS2(4), IRS4(16), LNPEP(2), PARD3(4), PARD6A(1), PDK1(1), PIK3CA(4), PIK3CD(2), PIK3R1(1), RPS6KA2(2), RPS6KA3(1), SHC1(1), SORBS1(2), SOS1(2), SOS2(1), YWHAE(2), YWHAG(1), YWHAH(1) 13280684 105 65 82 26 15 18 9 16 47 0 0.236 0.886 1.000 191 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(2), CYP11A1(1), CYP11B2(1), CYP17A1(1), HSD11B1(1), HSD3B1(2) 1521540 8 4 8 2 1 2 3 2 0 0 0.378 0.887 1.000 192 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(3), GABBR1(2), GPRC5A(2), GPRC5B(5), GPRC5C(3), GRM1(9), GRM2(4), GRM3(2), GRM4(3), GRM5(7), GRM7(4), GRM8(4) 4616253 48 19 48 15 17 14 8 6 3 0 0.108 0.887 1.000 193 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 FUT2(2), FUT5(1), FUT6(2) 1137293 5 2 5 0 3 2 0 0 0 0 0.0885 0.887 1.000 194 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(5), ATIC(2), DHFR(1), FTCD(2), GART(1), MTHFD1(2), MTHFD1L(1), MTHFD2(1), MTHFR(1), MTR(4), SHMT1(1), SHMT2(3), TYMS(1) 4186790 25 7 25 7 5 2 5 5 7 1 0.391 0.888 1.000 195 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(3), ME1(2), PC(3), PDHA1(2), SLC25A1(1) 2048173 11 5 11 4 4 5 1 1 0 0 0.400 0.889 1.000 196 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(3), DYRK1B(2), GLI2(4), GLI3(10), GSK3B(2), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), SMO(1), SUFU(1) 3738609 31 15 31 10 14 6 5 5 1 0 0.221 0.891 1.000 197 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 ASRGL1(1), GBA(3), GGT1(1), SHMT1(1), SHMT2(3) 1252078 9 5 9 6 3 2 1 1 2 0 0.868 0.891 1.000 198 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAS1(1), ALAS2(3), CPOX(1), HMBS(1), PPOX(1) 1681728 7 5 7 2 3 2 0 1 1 0 0.603 0.892 1.000 199 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(3), JUNB(1), MAF(2), MAP2K3(1), NFATC1(4), NFATC2(3), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1) 2761198 22 8 22 5 10 6 2 1 3 0 0.0414 0.894 1.000 200 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(2), ACADM(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(1), AOC2(2), AOC3(3), DPYD(4), DPYS(3), EHHADH(1), GAD1(5), GAD2(7), HADHA(1), UPB1(2) 5965763 35 16 35 5 10 6 8 5 5 1 0.0176 0.894 1.000 201 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(2), ACADL(2), ACADM(1), ACADSB(3), ALDH1A1(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(1), AOC2(2), AOC3(3), DPYD(4), DPYS(3), EHHADH(1), GAD1(5), GAD2(7), HADHA(1), UPB1(2) 6403257 41 18 41 5 12 8 8 6 6 1 0.00431 0.895 1.000 202 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(1), GUSB(1), RPE(2), UGDH(2), UGT1A1(1), UGT1A10(2), UGT1A4(2), UGT1A6(2), UGT1A7(1), UGT2B15(2), UGT2B4(1) 3850910 17 8 17 2 3 4 3 4 3 0 0.122 0.896 1.000 203 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(3), EP300(6), ESR1(1), SRC(2) 3334728 12 7 12 2 3 3 3 1 2 0 0.205 0.898 1.000 204 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 DHRS1(1), DHRS2(2), DHRS3(2), HSD3B7(3), PON1(1), PON2(1), RDH11(2) 1987487 12 4 12 2 3 1 3 4 1 0 0.279 0.902 1.000 205 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(1), HK1(4), HK2(6), HK3(4), ISYNA1(1), PGM1(1), TGDS(1) 2593940 18 10 18 5 9 1 2 0 6 0 0.350 0.902 1.000 206 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 ATM(10), CCND2(3), CDK4(2), EGR1(4), ESR2(2), FSHR(3), GJA4(2), LHCGR(2), MLH1(1), NCOR1(11), NRIP1(2), PGR(4), PRLR(2), SMPD1(2), ZP2(1) 7764446 51 22 51 9 13 6 13 9 10 0 0.0616 0.904 1.000 207 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(1), FDFT1(2), FDPS(1), HMGCR(5), IDI1(1), LSS(1), MVD(2), MVK(1), NQO2(2), SQLE(2), VKORC1(3) 2494159 21 7 20 5 5 7 6 1 2 0 0.151 0.906 1.000 208 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(2), ALDH3A1(1), ALDH3A2(1), MIOX(1), UGDH(2) 1894622 7 5 7 3 3 1 1 2 0 0 0.665 0.906 1.000 209 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CASP3(2), THBS1(3) 1622076 5 4 5 2 1 2 0 0 2 0 0.744 0.909 1.000 210 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 CTSD(2), ESR1(1), GREB1(7), PDZK1(1), TUBA8(4) 2478622 15 7 15 3 3 9 1 1 1 0 0.0473 0.910 1.000 211 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(1), AARS2(3), ABAT(2), ADSL(2), ADSS(1), ADSSL1(1), AGXT(2), AGXT2(1), ASL(2), ASNS(3), ASPA(1), ASRGL1(1), ASS1(1), CAD(6), DARS(1), DDO(2), DLAT(4), GAD1(5), GAD2(7), GOT1(2), GPT(1), GPT2(2), NARS2(1), PC(3), PDHA1(2), PDHA2(2) 8392616 59 21 59 15 15 14 14 7 8 1 0.103 0.910 1.000 212 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 10 CASP3(2), CASP7(1), DFFB(1), HMGB2(1), TOP2A(3), TOP2B(5) 2113635 13 6 13 2 2 2 2 2 5 0 0.548 0.911 1.000 213 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3E(1), CD4(2), LCK(1), PTPRC(2), ZAP70(6) 2013783 12 3 12 2 3 3 1 2 3 0 0.198 0.912 1.000 214 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 CDK5R1(1), EGR1(4), HRAS(1), KLK2(1), NGFR(1) 1849224 8 4 8 4 3 0 3 2 0 0 0.813 0.912 1.000 215 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(1), BCAT2(2), COASY(1), DPYD(4), DPYS(3), ENPP3(3), ILVBL(2), PANK2(1), PANK3(1), PANK4(1), PPCDC(1), UPB1(2), VNN1(1) 3860645 23 10 23 4 9 7 4 2 1 0 0.0436 0.913 1.000 216 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA2(1), GABRA4(5), GABRA5(5), GABRA6(2), PRKCE(1) 1755007 14 4 13 4 6 3 1 1 2 1 0.282 0.913 1.000 217 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CYB5R3(2), GCK(1), GFPT1(2), GNE(1), GNPDA1(2), HEXA(2), HEXB(2), HK1(4), HK2(6), HK3(4), RENBP(1), UAP1(1) 3751281 28 14 28 7 12 4 4 0 8 0 0.305 0.916 1.000 218 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 CARM1(2), DHRS1(1), DHRS2(2), DHRS3(2), HEMK1(1), LCMT1(1), LCMT2(1), METTL2B(2), METTL6(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(2) 3313978 21 7 21 5 4 6 7 2 2 0 0.270 0.918 1.000 219 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(2), GABRA2(1), GABRA4(5), GABRA5(5), GABRA6(2), GPHN(1), SRC(2), UBQLN1(3) 2670679 21 6 20 5 7 4 5 2 2 1 0.213 0.922 1.000 220 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 25 GHR(2), HRAS(1), INSR(4), IRS1(4), JAK2(6), PIK3CA(4), PIK3R1(1), PLCG1(1), PTPN6(4), SHC1(1), SOS1(2), SRF(1), STAT5A(1) 7317568 32 17 31 7 9 4 5 6 7 1 0.288 0.922 1.000 221 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(1), ELK1(2), HRAS(1), JAK1(1), MAP2K4(5), MAP3K1(3), MAPK8(2), PDGFRA(3), PIK3CA(4), PIK3R1(1), PLCG1(1), RASA1(2), SHC1(1), SOS1(2), SRF(1), STAT1(3), STAT3(2), STAT5A(1) 7721079 36 15 36 8 8 6 5 9 8 0 0.281 0.924 1.000 222 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(1), ESR2(2), PDE1B(1), PLCB1(1), PLCB2(4), PRL(6), TRH(2) 2486436 17 8 17 3 7 1 4 2 3 0 0.220 0.924 1.000 223 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP5(1), ACPT(1), ENPP3(3), FLAD1(1), RFK(1), TYR(4) 2139722 11 4 11 2 5 3 2 1 0 0 0.261 0.924 1.000 224 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYC(1), RB1(3), SP1(1), SP3(1) 1468417 6 2 6 0 1 0 3 1 1 0 0.354 0.925 1.000 225 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(3), EGF(5), EGFR(2), HGS(2) 2826174 12 4 12 1 0 5 3 2 2 0 0.138 0.927 1.000 226 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 CSNK2A1(1), HRAS(1), JAK2(6), PIK3CA(4), PIK3R1(1), PLCG1(1), RASA1(2), SHC1(1), SOS1(2), STAT1(3), STAT3(2), STAT5A(1), THPO(1) 6609417 26 13 25 5 4 5 3 5 9 0 0.353 0.928 1.000 227 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(5), ANAPC2(4), ANAPC4(3), ANAPC5(5), ANAPC7(1), BTRC(2), CDC16(1), CDC23(1), CDC27(7), CUL1(2), CUL2(1), CUL3(1), FBXW11(1), FBXW7(5), ITCH(2), SKP1(1), SKP2(3), SMURF2(1), TCEB1(2), UBA1(1), UBE2D1(1), UBE2E1(1), UBE2E3(2), WWP1(2), WWP2(5) 8955881 60 29 57 13 14 9 11 11 15 0 0.212 0.929 1.000 228 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 CSNK2A1(1), ELK1(2), HRAS(1), KLK2(1), MAPK8(2), NGFR(1), PIK3CA(4), PIK3R1(1), PLCG1(1), SHC1(1), SOS1(2) 4246708 17 8 17 3 3 4 2 4 4 0 0.222 0.929 1.000 229 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(3), CAPNS1(2), CAPNS2(2), EP300(6), MEF2D(2), NFATC1(4), NFATC2(3), PPP3CA(2), PPP3CC(1), SYT1(2) 5370880 27 11 27 8 8 8 0 4 6 1 0.223 0.931 1.000 230 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(4), F11(1), F12(2), F13B(2), F5(8), F8(3), FGA(4), FGB(4), FGG(2), LPA(8), PLAT(2), PLG(1), SERPINE1(2), SERPINF2(1), VWF(4) 7773395 48 21 46 12 13 8 15 6 6 0 0.171 0.932 1.000 231 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(1), JAK2(6), JAK3(3), STAT3(2), TYK2(2) 2638156 14 7 13 7 3 2 3 0 6 0 0.928 0.932 1.000 232 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 HRAS(1), MMP14(2), MMP2(2), MMP9(3), RECK(3) 1670505 11 4 11 4 5 2 2 0 2 0 0.439 0.932 1.000 233 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 22 AKT1(1), EIF4A2(2), EIF4G1(8), EIF4G2(1), EIF4G3(5), GHR(2), IRS1(4), PABPC1(9), PDK2(3), PIK3CA(4), PIK3R1(1) 6202937 40 24 35 10 7 6 8 7 11 1 0.579 0.934 1.000 234 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(3), ACO1(2), ACSS2(1), FH(3), IDH1(1), IDH2(5), SUCLA2(1) 2911116 16 7 16 5 5 3 5 2 1 0 0.470 0.936 1.000 235 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(2), CAT(1), EPX(4), LPO(5), MPO(2), MTHFR(1), SHMT1(1), SHMT2(3), TPO(7) 2569606 26 8 26 7 11 5 5 2 3 0 0.181 0.937 1.000 236 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(2), PSMA2(1), PSMA5(1), PSMA6(1), PSMB1(1), PSMB4(4), PSMB5(2), PSMB7(1) 1920504 13 9 13 6 5 0 2 2 4 0 0.783 0.938 1.000 237 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(4), COL4A2(6), COL4A3(2), COL4A4(4), COL4A5(3), COL4A6(4), F10(4), F11(1), F12(2), F5(8), F8(3), FGA(4), FGB(4), FGG(2), KLKB1(1), PROC(1), PROS1(2), SERPINC1(3), SERPING1(1) 9850314 59 23 58 12 10 11 26 6 5 1 0.128 0.938 1.000 238 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 MTMR2(2), MTMR6(2), NFS1(1), PHPT1(1), TPK1(1) 1409859 7 4 7 4 3 2 1 0 1 0 0.918 0.941 1.000 239 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(2), GRHPR(1), HAO1(1), HAO2(1), MTHFD1(2), MTHFD1L(1), MTHFD2(1) 2803885 9 4 9 0 2 3 1 0 2 1 0.0660 0.941 1.000 240 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 A4GALT(1), FUT2(2), FUT9(1), GBGT1(1), HEXA(2), HEXB(2), ST3GAL1(2), ST3GAL2(1), ST8SIA1(2) 2375284 14 6 14 2 6 3 3 0 2 0 0.0952 0.941 1.000 241 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 ATP6V0C(1), GGT1(1), SHMT1(1), SHMT2(3) 950169 6 2 6 6 2 1 2 0 1 0 0.965 0.942 1.000 242 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(2), SUCLA2(1) 471124 3 1 3 1 0 1 2 0 0 0 0.757 0.942 1.000 243 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(2), PSMA2(1), PSMA5(1), PSMA6(1), PSMB1(1), PSMB4(4), PSMB5(2), PSMB7(1), UBE3A(4) 2849997 17 10 17 5 7 1 2 3 4 0 0.458 0.942 1.000 244 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(1), EGF(5), EGFR(2), ELK1(2), HRAS(1), JAK1(1), MAP2K4(5), MAP3K1(3), MAPK8(2), PIK3CA(4), PIK3R1(1), PLCG1(1), RASA1(2), SHC1(1), SOS1(2), SRF(1), STAT1(3), STAT3(2), STAT5A(1) 8279866 40 18 40 9 6 8 6 10 10 0 0.299 0.942 1.000 245 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(2), ATP6V0C(1), CAT(1), EPX(4), LPO(5), MPO(2), PRDX1(1), SHMT1(1), SHMT2(3), TPO(7) 2626271 27 8 27 7 11 5 7 1 3 0 0.157 0.943 1.000 246 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(2), HEMK1(1), LCMT1(1), LCMT2(1), METTL2B(2), METTL6(1), PCYT1A(2), PCYT1B(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(2) 3121301 19 7 19 5 3 8 6 1 1 0 0.283 0.944 1.000 247 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(3), CD34(1), CD3E(1), CD4(2), CD58(1), IL6(1) 1375965 9 2 9 1 1 1 1 2 4 0 0.312 0.945 1.000 248 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(2), AASDH(2), AASS(2), KARS(1) 1524275 7 2 7 3 0 0 3 1 3 0 0.948 0.945 1.000 249 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CD4(2), IL1B(1), IL6(1) 1168938 4 1 4 2 0 0 1 1 2 0 0.839 0.947 1.000 250 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(1), IARS(4), LARS2(1), PDHA1(2), PDHA2(2) 2197324 10 4 10 3 4 2 2 2 0 0 0.543 0.947 1.000 251 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 CDC42(1), CREB1(2), DAXX(3), ELK1(2), HRAS(1), MAP2K4(5), MAP2K6(3), MAP3K1(3), MAP3K5(1), MAP3K7(2), MAP3K9(6), MAPKAPK5(1), MAX(1), MEF2A(1), MEF2C(3), MEF2D(2), RPS6KA5(2), SHC1(1), STAT1(3), TGFB1(1), TGFBR1(8), TRADD(1), TRAF2(1) 8186760 54 27 53 13 16 8 11 7 12 0 0.190 0.951 1.000 252 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 EPO(2), EPOR(2), GRIN1(1), HIF1A(1), JAK2(6), NFKBIA(1), RELA(2) 2834031 15 6 14 3 4 1 4 0 6 0 0.478 0.951 1.000 253 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 DLG4(3), GRIN1(1), GRIN2A(6), GRIN2B(7), GRIN2C(4), GRIN2D(5), NOS1(7), PPP3CA(2), PPP3CC(1), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), SYT1(2) 5718322 46 18 45 12 19 7 7 9 3 1 0.0628 0.951 1.000 254 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 19 APAF1(3), BAK1(1), BIK(1), BIRC2(2), CASP3(2), CASP7(1), CASP8(2), CASP9(1), DFFB(1), DIABLO(1) 3008592 15 5 15 3 2 3 3 1 5 1 0.438 0.951 1.000 255 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(4), ICAM1(2), ITGA4(1), ITGAL(2), ITGB2(1), SELE(2), SELL(1) 2672720 13 6 13 6 4 1 2 3 3 0 0.649 0.952 1.000 256 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 FUT2(2), FUT9(1), GCNT2(1), ST8SIA1(2) 1385375 6 2 6 0 4 1 1 0 0 0 0.0848 0.953 1.000 257 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDHB(1), MUT(2) 1094970 3 1 3 2 0 0 0 1 2 0 0.905 0.954 1.000 258 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 F13A1(3), FGA(4), FGB(4), FGG(2), PLAT(2), PLG(1), SERPINE1(2) 2944902 18 6 18 6 3 3 5 5 2 0 0.553 0.955 1.000 259 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(4), LPO(5), MPO(2), PRDX1(1), TPO(7), TYR(4) 2144345 23 9 23 8 12 1 6 2 2 0 0.448 0.955 1.000 260 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(3), EGF(5), EGFR(2), HRAS(1), PTPRB(10), RASA1(2), SHC1(1), SOS1(2), SRC(2) 5509288 28 11 28 3 2 9 5 6 5 1 0.0338 0.956 1.000 261 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT1(1), AKT2(2), AKT3(2), ELK1(2), HRAS(1), NGFR(1), NTRK1(2), PIK3CA(4), PIK3CD(2), SHC1(1), SOS1(2) 3660069 20 10 20 6 7 2 2 5 4 0 0.472 0.956 1.000 262 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(3), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(4), ALDH1A3(2), ALDH3A1(1), ALDH3A2(1) 2934049 20 5 20 7 8 5 2 2 3 0 0.441 0.956 1.000 263 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 AKT1(1), AKT2(2), AKT3(2), BPNT1(2), ILK(1), PDK1(1), PIK3CA(4), PIK3CD(2), RBL2(6), SHC1(1), SOS1(2) 4513333 24 11 23 6 4 2 4 7 7 0 0.528 0.959 1.000 264 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(2), TAT(1) 576152 3 1 3 1 0 1 1 1 0 0 0.760 0.962 1.000 265 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(5), ARHGEF1(2), GNAQ(1), GNB1(3), MYLK(13), PLCB1(1), ROCK1(5) 4566025 30 14 29 9 6 8 4 5 7 0 0.410 0.964 1.000 266 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 AKT1(1), CREB1(2), MAP2K3(1), MAP2K6(3), MAP3K1(3), PIK3CA(4), PIK3R1(1), RB1(3), RELA(2), SP1(1) 4309068 21 10 21 9 3 1 7 5 5 0 0.908 0.964 1.000 267 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 CASP8(2), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(1) 1909796 7 3 7 5 3 0 2 0 2 0 0.902 0.964 1.000 268 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 AKT1(1), BCAR1(2), ILK(1), PDK2(3), PIK3CA(4), PIK3R1(1), PTK2(3), SHC1(1), SOS1(2) 4315007 18 7 18 3 4 4 4 4 2 0 0.147 0.965 1.000 269 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 ADCY1(4), AKT1(1), ASAH1(1), GNAI1(1), GNB1(3), ITGAV(3), ITGB3(1), PDGFRA(3), PIK3CA(4), PIK3R1(1), PLCB1(1), PTK2(3), SMPD1(2), SPHK1(1), SRC(2) 6050059 31 11 31 5 7 10 3 6 5 0 0.0418 0.965 1.000 270 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(4), ICAM1(2), ITGA4(1), ITGAL(2), ITGAM(4), ITGB2(1), SELE(2), SELL(1), SELP(2) 3537271 19 8 18 6 5 3 2 3 6 0 0.436 0.965 1.000 271 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPLD1(2), PGAP1(2), PIGB(2), PIGC(1), PIGG(2), PIGL(2), PIGM(1), PIGO(4), PIGQ(6), PIGS(3), PIGW(2) 5345783 27 11 27 3 6 6 6 4 5 0 0.0185 0.965 1.000 272 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(4), EIF2AK4(1), EIF2B5(1), EIF5(3), GSK3B(2), PPP1CA(1) 2555346 12 4 12 4 2 3 4 0 3 0 0.702 0.967 1.000 273 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 DLAT(4), FH(3), IDH2(5), IDH3A(2), IDH3G(2), OGDH(5), PC(3), PDHA1(2), PDHA2(2), PDK1(1), PDK2(3), PDK4(1), SDHA(3), SUCLA2(1), SUCLG1(3) 6292420 40 15 40 8 9 8 13 6 4 0 0.0778 0.968 1.000 274 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(2), IL10RA(2), IL10RB(1), IL6(1), JAK1(1), STAT1(3), STAT3(2), STAT5A(1) 2683714 13 5 13 5 7 2 2 1 1 0 0.589 0.968 1.000 275 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 CDK5R1(1), RELN(13), VLDLR(3) 3077704 17 10 17 8 6 3 3 2 2 1 0.813 0.969 1.000 276 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 GNAQ(1), NFATC1(4), NFATC2(3), NFATC3(2), NFATC4(5), PLCG1(1), PPP3CA(2), PPP3CC(1), SP1(1), SP3(1), SYT1(2) 4649800 23 7 23 5 5 7 2 3 5 1 0.159 0.970 1.000 277 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 AKT1(1), BCR(2), CRKL(1), HRAS(1), JAK2(6), MAP2K4(5), MAP3K1(3), MAPK8(2), PIK3CA(4), PIK3R1(1), SOS1(2), STAT1(3), STAT5A(1) 6211567 32 15 31 8 7 2 6 9 8 0 0.495 0.970 1.000 278 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(1), FARSA(1), FARSB(1), GOT1(2), PAH(1), TAT(1) 1916203 7 4 7 3 2 2 2 1 0 0 0.734 0.971 1.000 279 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(1), GAD1(5), TH(1), TPH1(2) 1350803 9 3 9 5 3 0 3 1 1 1 0.786 0.971 1.000 280 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP5(1), ACPT(1), ENPP3(3), FLAD1(1), MTMR2(2), MTMR6(2), PHPT1(1), RFK(1), TYR(4) 3321331 16 6 16 5 7 4 3 1 1 0 0.527 0.971 1.000 281 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 CISH(1), IFNGR1(2), JAK1(1), JAK2(6), PTPRU(6), REG1A(1), STAT1(3) 2525406 20 11 18 7 7 0 5 2 6 0 0.773 0.972 1.000 282 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CAMK1(2), CAMK1G(2), CAMK2D(1), CAMK4(1), ESRRA(2), HDAC5(2), MEF2A(1), MEF2C(3), MEF2D(2), PPARA(1), PPP3CA(2), PPP3CC(1), SYT1(2), YWHAH(1) 4523484 23 10 23 4 4 5 5 3 5 1 0.112 0.973 1.000 283 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 131 ACTB(1), ACTN1(1), ACTN2(4), AKT1(1), AKT2(2), AKT3(2), AMOTL1(1), ASH1L(9), CDC42(1), CDK4(2), CGN(1), CLDN17(3), CLDN22(1), CLDN3(2), CLDN9(2), CSNK2A1(1), CTNNA1(4), CTNNA2(5), CTNNA3(5), CTNNB1(7), CTTN(2), EPB41(4), EPB41L1(3), EPB41L2(2), EPB41L3(4), EXOC3(1), EXOC4(2), F11R(1), GNAI1(1), GNAI2(1), HCLS1(1), HRAS(1), IGSF5(1), INADL(2), JAM2(2), KRAS(126), LLGL1(5), LLGL2(3), MAGI1(2), MAGI2(10), MAGI3(3), MLLT4(4), MPDZ(3), MYH1(6), MYH10(4), MYH11(7), MYH13(3), MYH14(4), MYH15(8), MYH2(3), MYH3(2), MYH4(9), MYH6(6), MYH7(8), MYH7B(8), MYH8(4), MYH9(4), MYL9(1), PARD3(4), PARD6A(1), PPP2CA(1), PPP2R1A(4), PPP2R1B(3), PPP2R2A(2), PPP2R2B(2), PPP2R3A(3), PRKCD(4), PRKCE(1), PRKCG(2), PRKCH(1), PRKCI(4), PRKCQ(2), RAB13(1), RAB3B(1), RHOA(1), RRAS(2), SPTAN1(4), SRC(2), SYMPK(5), TJP1(6), TJP2(4), TJP3(3), YES1(1), ZAK(2) 43339819 382 135 259 76 82 99 111 50 40 0 4.66e-08 0.973 1.000 284 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(1) 1766118 5 4 5 2 4 0 1 0 0 0 0.620 0.974 1.000 285 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(1) 1766118 5 4 5 2 4 0 1 0 0 0 0.620 0.974 1.000 286 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 B3GNT2(2), B3GNT3(1), B3GNT4(1), B3GNT5(1), B4GALT2(1), FUT2(2), FUT4(1), FUT5(1), FUT6(2), FUT9(1), GCNT2(1), ST8SIA1(2) 3641425 16 6 16 1 8 4 4 0 0 0 0.0106 0.974 1.000 287 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CXCR4(3), GNAQ(1), MAPK8(2), PLCG1(1), SYT1(2) 3050552 9 4 9 5 0 2 1 2 3 1 0.821 0.975 1.000 288 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(3), CD3E(1), ICAM1(2), ITGAL(2), ITGB2(1), PTPRC(2), THY1(1) 2354390 12 4 12 3 6 1 0 2 3 0 0.273 0.975 1.000 289 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOB(2), FBP2(1), GOT1(2), GPT(1), GPT2(2), ME1(2), ME3(1), PGK1(3), PKLR(2), RPE(2), RPIA(1), TKT(1), TPI1(3) 4457095 23 8 23 3 4 8 8 2 1 0 0.0241 0.975 1.000 290 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(2), ALDH4A1(3), ALDH5A1(2), CAD(6), CPS1(4), EPRS(1), GAD1(5), GAD2(7), GCLC(1), GCLM(1), GFPT1(2), GLS(1), GOT1(2), GPT(1), GPT2(2), NADSYN1(4), PPAT(2), QARS(2) 7342170 48 15 48 11 9 10 12 6 9 2 0.173 0.976 1.000 291 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(2), ALDH4A1(3), ALDH5A1(2), CAD(6), CPS1(4), EARS2(1), EPRS(1), GAD1(5), GAD2(7), GCLC(1), GCLM(1), GFPT1(2), GFPT2(2), GLS(1), GLUD2(3), GOT1(2), GPT(1), GPT2(2), GSR(1), NADSYN1(4), NAGK(1), PPAT(2), QARS(2) 8743496 56 18 56 13 10 12 16 7 9 2 0.138 0.976 1.000 292 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(5), DIAPH1(7), GSN(4), HRAS(1), ITGA1(7), MYLK(13), PIK3CA(4), PIK3R1(1), PTK2(3), PXN(1), ROCK1(5), SHC1(1), SRC(2), TLN1(12) 8260745 66 27 63 12 18 16 9 9 13 1 0.0183 0.976 1.000 293 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(3), CCNE1(1), CDC34(1), CUL1(2), RB1(3), SKP2(3), TFDP1(1) 1906489 14 6 14 8 3 4 3 3 1 0 0.892 0.976 1.000 294 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(3), BAD(1), BAK1(1), CASP9(1), CES1(2) 2493077 8 2 8 2 2 3 3 0 0 0 0.468 0.976 1.000 295 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CCNE1(1), CUL1(2), RB1(3), SKP2(3), TFDP1(1) 1899569 10 5 10 6 2 2 2 3 1 0 0.927 0.977 1.000 296 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 INPP4A(2), INPP4B(1), INPP5A(1), INPPL1(2), ITPKB(3), MIOX(1), OCRL(1), PIK3C2A(5), PIK3C2B(10), PIK3CA(4), PIK3CB(1), PIK3CG(4), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), PLCD1(1), PLCG1(1), PLCG2(7) 9993317 55 20 55 12 20 7 7 12 9 0 0.0603 0.977 1.000 297 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(1), EHHADH(1), HADHA(1) 2686698 7 5 7 3 4 0 2 0 1 0 0.635 0.977 1.000 298 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(3), CD3E(1), CD4(2), ICAM1(2), ITGAL(2), ITGB2(1), PTPRC(2), THY1(1) 2472258 14 4 14 4 6 1 0 3 4 0 0.383 0.978 1.000 299 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 DHCR7(1), FDFT1(2), FDPS(1), HMGCR(5), IDI1(1), LSS(1), MVD(2), MVK(1), NSDHL(2), SQLE(2) 2952807 18 7 17 6 6 6 4 0 2 0 0.375 0.978 1.000 300 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 ANKHD1(3), EEF1A2(1), EEF1B2(1), EEF1D(1), EEF1G(2), EEF2(6), EIF2AK2(2), EIF2AK3(4), EIF2B1(1), EIF2B2(2), EIF2B3(1), EIF2B5(1), EIF4A2(2), EIF4EBP2(1), EIF4G1(8), EIF4G3(5), EIF5(3), EIF5B(2), ETF1(1), PABPC1(9), PABPC3(5), SLC35A4(2) 9833824 63 27 57 11 12 11 15 9 16 0 0.119 0.978 1.000 301 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(3), ACTN1(1), ACTN2(4), CAPN1(1), CAPNS1(2), CAPNS2(2), ITGA1(7), ITGB3(1), PTK2(3), PXN(1), SPTAN1(4), SRC(2), TLN1(12) 6368183 43 12 43 6 15 12 4 4 7 1 0.00370 0.978 1.000 302 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAS1(1), ALAS2(3), CPO(2), HBB(1), HMBS(1) 1783537 8 6 8 4 4 1 1 0 2 0 0.789 0.979 1.000 303 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(4), ARHGEF1(2), F2RL3(1), GNAI1(1), GNAQ(1), GNB1(3), MAP3K7(2), PIK3CA(4), PIK3R1(1), PLCB1(1), ROCK1(5) 5758882 25 12 25 7 4 7 4 6 4 0 0.342 0.979 1.000 304 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(3), APAF1(3), CASP3(2), CASP9(1), DAXX(3), FASLG(1), MAPKAPK3(1) 2507784 14 4 14 2 3 5 2 2 2 0 0.137 0.979 1.000 305 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(3), BIRC2(2), CASP10(3), CASP3(2), CASP7(1), CASP8(2), CASP9(1), CFLAR(3), CHUK(1), DFFB(1), GAS2(3), NFKBIA(1), RELA(2), SPTAN1(4), TNFRSF10A(2), TNFRSF10B(2), TNFSF12(2), TRADD(1), TRAF2(1) 7497621 37 14 37 7 11 7 5 2 12 0 0.110 0.980 1.000 306 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(3), ACO1(2), FH(3), IDH1(1), IDH2(5), IDH3A(2), IDH3G(2), OGDH(5), OGDHL(1), PC(3), PCK1(3), PCK2(2), SDHA(3), SUCLA2(1), SUCLG1(3) 6570722 39 14 39 11 11 7 12 6 2 1 0.217 0.981 1.000 307 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ALDH1A3(2), ALDH3A1(1), ALDH3B1(2), ALDH3B2(1), AOC2(2), AOC3(3), DDC(1), EPX(4), GOT1(2), HPD(3), LPO(5), MPO(2), PRDX1(1), TAT(1), TPO(7) 4880382 37 13 37 7 18 6 8 3 2 0 0.0187 0.981 1.000 308 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 33 AKT1(1), AKT2(2), AKT3(2), BCR(2), BTK(1), CD19(1), CDKN2A(31), DAPP1(2), FLOT2(1), ITPR1(10), ITPR2(4), ITPR3(8), PDK1(1), PHF11(1), PIK3CA(4), PLCG2(7), PREX1(8), PTPRC(2), RPS6KA2(2), RPS6KA3(1), SAG(1), SYK(2), TEC(2), VAV1(4) 12352205 100 50 88 20 25 12 12 16 34 1 0.0182 0.982 1.000 309 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 AKT1(1), APC(7), AXIN1(3), CD14(1), CTNNB1(7), DVL1(4), FZD1(5), GJA1(1), GNAI1(1), GSK3B(2), LBP(1), LEF1(2), LY96(1), PIK3CA(4), PIK3R1(1), PPP2CA(1), RELA(2), TLR4(1), WNT1(1) 6872038 46 16 46 7 13 8 8 15 2 0 0.0190 0.982 1.000 310 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ALDH18A1(1), ARG1(1), ARG2(1), ASL(2), CKB(1), CKM(3), CKMT1A(1), CKMT1B(1), CKMT2(2), CPS1(4), OAT(2), ODC1(1), PYCR1(1) 3942723 21 5 21 2 7 3 6 3 1 1 0.0337 0.982 1.000 311 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(1), ALDOB(2), FBP2(1), FPGT(1), GCK(1), GMDS(1), GMPPA(3), HK1(4), HK2(6), HK3(4), PFKFB1(2), PFKFB3(1), PFKFB4(2), PFKM(3), PMM2(2), TPI1(3) 5311585 37 17 37 10 16 5 8 2 6 0 0.187 0.982 1.000 312 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ADCY4(1), ADCY6(3), ADCY8(4), CACNA1A(8), CACNA1B(13), GNAS(12), GNB1(3), GNB3(2), GRM4(3), ITPR3(8), KCNB1(5), PLCB2(4), PRKACB(1), PRKACG(3), SCNN1A(2), SCNN1B(1), SCNN1G(1), TAS1R1(2), TAS1R2(3), TAS1R3(2), TAS2R1(3), TAS2R10(1), TAS2R13(2), TAS2R16(3), TAS2R3(2), TAS2R38(3), TAS2R4(1), TAS2R41(1), TAS2R42(1), TAS2R50(1), TAS2R60(1), TAS2R7(2), TAS2R8(1), TAS2R9(2), TRPM5(1) 12992431 106 38 101 22 44 15 16 12 19 0 0.00144 0.982 1.000 313 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(2), CD44(4), CSF1(2), IL1B(1), IL6R(1), SELL(1), TGFB1(1), TNFRSF1A(2), TNFRSF1B(1), TNFRSF8(1), TNFSF8(3) 3013921 19 7 19 8 6 1 4 5 3 0 0.608 0.982 1.000 314 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CD2(3), CD3E(1), CD4(2), IL12B(1), JAK2(6), STAT4(1), TYK2(2) 3277872 16 7 15 5 2 1 3 2 8 0 0.814 0.983 1.000 315 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 89 ACVR1B(2), ACVR1C(1), ACVR2A(4), ACVRL1(1), AMH(1), AMHR2(3), BMP2(1), BMP4(2), BMP5(2), BMP7(1), BMP8B(1), BMPR1A(3), BMPR2(3), CHRD(2), COMP(2), CREBBP(3), CUL1(2), DCN(1), E2F4(3), E2F5(3), EP300(6), GDF5(1), GDF6(1), GDF7(2), INHBA(2), INHBB(2), INHBC(1), LEFTY2(1), LTBP1(3), NODAL(1), PPP2CA(1), PPP2R1A(4), PPP2R1B(3), PPP2R2A(2), PPP2R2B(2), RBL1(2), RBL2(6), RHOA(1), ROCK1(5), ROCK2(2), RPS6KB2(1), SKP1(1), SMAD2(1), SMAD4(32), SMAD7(1), SMAD9(3), SMURF2(1), SP1(1), TFDP1(1), TGFB1(1), TGFBR1(8), TGFBR2(10), THBS1(3), THBS2(4), THBS4(2), ZFYVE16(6), ZFYVE9(5) 22160127 170 74 166 35 41 32 26 26 45 0 0.00350 0.984 1.000 316 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(1), BCAT2(2), IARS(4), ILVBL(2), LARS2(1), PDHA1(2), PDHA2(2), VARS(3), VARS2(2) 4099051 19 7 19 6 8 4 3 2 2 0 0.469 0.984 1.000 317 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 ABAT(2), ACADS(1), ACAT1(2), ACAT2(1), ACSM1(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(1), ALDH5A1(2), BDH1(1), BDH2(1), DDHD1(3), EHHADH(1), GAD1(5), GAD2(7), HADH(1), HADHA(1), HMGCS2(2), HSD17B4(3), HSD3B7(3), ILVBL(2), L2HGDH(2), OXCT1(2), OXCT2(1), PDHA1(2), PDHA2(2), PLA1A(2), RDH11(2) 9011891 56 23 56 10 13 12 13 8 9 1 0.0212 0.984 1.000 318 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 CREBBP(3), DFFB(1), HMGB2(1), NME1(1), PRF1(1), SET(1) 2356964 8 4 8 3 2 2 2 1 1 0 0.569 0.985 1.000 319 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 28 ANXA1(3), ANXA6(3), CYP11A1(1), EDN1(1), EDNRB(2), HSD11B1(1), PRL(6), PTGDR(2), PTGDS(2), PTGFR(2), PTGIS(2), PTGS1(1), TBXAS1(1) 4627481 27 11 27 8 9 2 6 6 4 0 0.439 0.985 1.000 320 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSA(1), ARSB(2), ARSE(1), ASAH1(1), GAL3ST1(1), GALC(2), GBA(3), GLB1(2), LCT(5), NEU4(1), PPAP2B(2), PPAP2C(1), SMPD1(2), SPTLC1(3), SPTLC2(1), UGCG(1) 5436401 29 13 29 9 10 7 2 2 7 1 0.202 0.987 1.000 321 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(3), BIRC2(2), CASP10(3), CASP3(2), CASP7(1), CASP8(2), CASP9(1), DFFB(1), PRF1(1), SCAP(3), SREBF2(2) 4148220 21 8 21 5 5 6 2 1 7 0 0.253 0.988 1.000 322 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 23 APC(7), AXIN1(3), BTRC(2), CREBBP(3), CSNK1D(1), CSNK2A1(1), CTNNB1(7), DVL1(4), FZD1(5), GSK3B(2), MAP3K7(2), NLK(2), PPARD(1), PPP2CA(1), TLE1(2), WIF1(2), WNT1(1) 6633366 46 16 46 8 13 9 10 11 3 0 0.0262 0.988 1.000 323 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(2), CD38(2), ENPP3(3), NADSYN1(4), NNT(5), NT5E(1), NT5M(1) 3214431 18 5 18 6 5 3 5 3 2 0 0.500 0.988 1.000 324 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(3), BIRC2(2), CASP1(1), CASP10(3), CASP2(3), CASP3(2), CASP4(2), CASP7(1), CASP8(2), CASP9(1), DFFB(1), LMNB2(1), PRF1(1) 4274089 23 8 23 3 5 6 5 1 6 0 0.0952 0.988 1.000 325 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 ADAM17(4), APC(7), AXIN1(3), BTRC(2), CTNNB1(7), DLL1(2), DVL1(4), FZD1(5), GSK3B(2), NOTCH1(9), PSEN1(1), WNT1(1) 4881109 47 15 47 10 15 14 6 9 3 0 0.0273 0.989 1.000 326 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(4), ACAT1(2), ACAT2(1), ADH5(2), AKR1B1(1), ALDH1A1(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(1), DLAT(4), GLO1(2), GRHPR(1), HAGH(2), LDHB(1), ME1(2), ME2(6), ME3(1), PC(3), PCK1(3), PDHA1(2), PDHA2(2), PKLR(2) 8155021 46 17 46 8 10 19 5 3 9 0 0.0170 0.989 1.000 327 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 AKT1(1), EIF2B5(1), GSK3B(2), IGF1R(6), INPPL1(2), PDK2(3), PIK3CA(4), PIK3R1(1), PPP2CA(1) 4366285 21 10 21 9 4 3 3 6 5 0 0.813 0.989 1.000 328 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 ASNS(3), ASRGL1(1), CA5B(1), CA6(1), CA8(1), CA9(1), CPS1(4), GLS(1), GLUD2(3), HAL(1) 4690180 17 6 17 5 4 7 2 1 2 1 0.443 0.989 1.000 329 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG3(1), ATG7(2), BECN1(2), GABARAPL1(1), IFNA10(1), IFNA16(1), IFNA7(2), PIK3C3(2), PIK3R4(4), PRKAA1(2), PRKAA2(1), ULK1(3), ULK3(1) 4723702 23 9 23 5 6 5 1 7 4 0 0.234 0.989 1.000 330 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS2(2), GOT1(2), LDHAL6A(1), LDHAL6B(2), LDHB(1), SULT1B1(1), SULT1C4(1), SULT4A1(1) 2787034 11 4 11 5 1 2 2 3 3 0 0.863 0.989 1.000 331 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(2), ACE2(3), AGT(1), ANPEP(3), CMA1(1), CPA3(1), CTSA(1), CTSG(2), ENPEP(3), LNPEP(2), MME(2), NLN(1), REN(3), THOP1(1) 4677188 26 9 26 6 4 8 7 5 1 1 0.147 0.990 1.000 332 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ADAM17(4), ERBB4(6), NRG2(1), PSEN1(1) 2007670 12 4 12 5 1 5 1 3 2 0 0.778 0.990 1.000 333 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1(2), CSF1R(1), DDX20(1), E2F4(3), ETS1(2), ETS2(2), HDAC5(2), HRAS(1), NCOR2(3), RBL1(2), RBL2(6), SIN3A(4) 5893812 29 11 28 8 5 6 7 5 6 0 0.347 0.990 1.000 334 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT2(2), B3GNT7(1), B4GALT2(1), CHST1(1), CHST2(2), CHST4(1), CHST6(2), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2) 2799190 15 6 15 2 5 1 6 2 1 0 0.0916 0.991 1.000 335 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(1), MAPK8(2), RELA(2), TNFRSF13B(1), TNFRSF13C(1), TNFSF13(3), TRAF2(1), TRAF5(1), TRAF6(1) 3248040 13 4 13 4 2 1 5 1 4 0 0.718 0.991 1.000 336 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 ARSB(2), ARSE(1), CYP11B1(4), CYP11B2(1), HSD11B1(1), HSD17B2(2), HSD3B1(2), STS(4), SULT2A1(1), UGT1A1(1), UGT1A10(2), UGT1A4(2), UGT1A6(2), UGT1A7(1), UGT2B15(2), UGT2B4(1) 6032020 29 13 29 8 10 8 4 3 4 0 0.194 0.991 1.000 337 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(1), ACTN2(4), BCAR1(2), CSK(1), CTNNA1(4), CTNNA2(5), CTNNB1(7), PTK2(3), PXN(1), SRC(2), VCL(1) 4330927 31 7 31 4 13 9 1 7 1 0 0.00556 0.991 1.000 338 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGT(1), EGFR(2), ELK1(2), GNAQ(1), HRAS(1), MAP2K4(5), MAP3K1(3), MAPK8(2), MEF2A(1), MEF2C(3), MEF2D(2), PTK2(3), SHC1(1), SOS1(2), SRC(2), SYT1(2) 7448311 33 12 33 8 5 7 6 6 8 1 0.269 0.991 1.000 339 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 CASP10(3), CASP3(2), CASP7(1), CASP8(2), CFLAR(3), DAXX(3), DFFB(1), FAF1(1), LMNB2(1), MAP2K4(5), MAP3K1(3), MAP3K7(2), MAPK8(2), PAK2(2), PRKDC(7), PTPN13(4), RB1(3), SPTAN1(4) 9224417 49 17 49 11 9 5 10 13 12 0 0.285 0.991 1.000 340 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CD4(2), CSF1(2), IL12B(1), IL6(1), IL7(1), TGFB1(1) 2969618 8 2 8 4 1 2 1 3 1 0 0.783 0.992 1.000 341 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(3), AKT1(1), BDKRB2(1), CHRM1(1), CHRNA1(4), FLT1(3), FLT4(9), KDR(1), NOS3(8), PDE2A(1), PDE3A(8), PDE3B(2), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PRKG1(1), PRKG2(1), RYR2(15), SLC7A1(1), SYT1(2), TNNI1(1) 9115084 71 32 71 13 30 10 13 6 11 1 0.00234 0.992 1.000 342 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP5(1), ACPT(1), ALPI(2), ALPL(2), ALPP(3), ALPPL2(4), CYP3A5(1), CYP3A7(2), DHRS1(1), DHRS2(2), DHRS3(2), PON1(1), PON2(1) 4009188 23 7 23 7 10 4 2 5 2 0 0.282 0.992 1.000 343 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(2), GLB1(2), GNS(1), GUSB(1), HEXA(2), HEXB(2), LCT(5), NAGLU(2) 3252120 17 9 17 9 4 3 2 2 5 1 0.859 0.992 1.000 344 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(3), ARG1(1), ARG2(1), ASL(2), ASS1(1), CKB(1), CKM(3), CKMT1A(1), CKMT1B(1), CKMT2(2), CPS1(4), DAO(2), EPRS(1), GLUD2(3), GOT1(2), LAP3(1), NOS1(7), NOS3(8), OAT(2), P4HA1(4), P4HA2(1), P4HA3(1), PARS2(1), PRODH(2), PYCR1(1), RARS(1), RARS2(3) 8003984 60 20 60 11 21 9 17 8 4 1 0.0175 0.993 1.000 345 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNAR1(2), IFNAR2(2), JAK1(1), STAT1(3), STAT2(1), TYK2(2) 2399570 11 6 11 5 4 0 3 3 1 0 0.807 0.993 1.000 346 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 67 A2M(1), BDKRB2(1), C1QA(1), C1QB(35), C1QC(1), C1R(1), C1S(6), C2(2), C3(11), C3AR1(3), C4BPB(2), C5(2), C5AR1(1), C6(6), C7(4), C8A(4), C9(2), CD46(1), CD55(1), CD59(1), CFB(3), CFD(1), CFH(4), CFI(2), CR1(4), CR2(5), F10(4), F11(1), F12(2), F13A1(3), F13B(2), F5(8), F8(3), FGA(4), FGB(4), FGG(2), KLKB1(1), KNG1(1), MASP1(2), PLAT(2), PLG(1), PROC(1), PROS1(2), SERPINA1(2), SERPINA5(1), SERPINC1(3), SERPINE1(2), SERPINF2(1), SERPING1(1), TFPI(2), THBD(3), VWF(4) 20027080 167 68 132 38 35 22 29 24 57 0 0.111 0.993 1.000 347 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(7), AXIN1(3), CREBBP(3), CTNNB1(7), DVL1(4), EP300(6), FZD1(5), GSK3B(2), LDB1(2), LEF1(2), TRRAP(11), WNT1(1) 7360120 53 16 53 11 19 9 8 13 3 1 0.0331 0.993 1.000 348 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CD3E(1), ETV5(2), IL12B(1), JAK2(6), MAP2K6(3), MAPK8(2), STAT4(1), TYK2(2) 4147405 18 8 17 5 3 1 4 1 9 0 0.588 0.993 1.000 349 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(3), AGT(1), CMA1(1), COL4A1(4), COL4A2(6), COL4A3(2), COL4A4(4), COL4A5(3), COL4A6(4), REN(3) 5604442 31 11 31 4 6 7 13 2 2 1 0.0587 0.994 1.000 350 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 14 MTNR1A(2), MTNR1B(2), PTGDR(2), PTGFR(2), TBXA2R(1) 2564039 9 5 9 9 2 1 4 0 2 0 0.963 0.994 1.000 351 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 B3GNT6(2), B4GALT5(2), C1GALT1(1), GALNT1(3), GALNT10(5), GALNT13(2), GALNT2(2), GALNT5(4), GALNT6(2), GALNT7(2), GALNT8(1), GALNT9(1), GALNTL5(2), OGT(4), ST3GAL1(2), ST3GAL2(1), ST6GALNAC1(1), WBSCR17(2) 7125760 39 19 38 10 11 6 9 4 9 0 0.335 0.994 1.000 352 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(5), ABCB11(2), ABCB4(1), ABCC1(1), ABCC3(2), GSTP1(1) 3157488 12 6 12 3 1 3 3 4 1 0 0.416 0.994 1.000 353 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOB(2), FBP2(1), GPI(3), H6PD(6), PFKM(3), PGD(1), PGLS(1), PGM1(1), PRPS1(1), PRPS1L1(3), RBKS(1), RPE(2), RPIA(1), TAL1(1), TKT(1) 4525212 28 11 28 9 10 4 8 3 3 0 0.300 0.994 1.000 354 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 CASP2(3), CASP3(2), CASP8(2), CRADD(2), DFFB(1), LMNB2(1), MADD(3), MAP2K4(5), MAP3K1(3), MAP3K7(2), MAPK8(2), PAK2(2), PRKDC(7), RB1(3), SPTAN1(4), TNFRSF1A(2), TRADD(1), TRAF2(1) 8760411 46 14 46 8 13 2 11 9 11 0 0.101 0.994 1.000 355 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(2), ADSS(1), DHFR(1), IMPDH1(2), MTHFD2(1), POLB(1), POLD1(2), POLG(4), RRM1(1) 2853640 15 4 15 4 4 6 1 1 3 0 0.190 0.994 1.000 356 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(2), EXT2(4), EXTL1(3), EXTL2(4), EXTL3(6), GLCE(2), HS2ST1(1), HS3ST2(3), HS6ST1(2), HS6ST2(1), NDST1(3), NDST3(3), NDST4(2) 4666888 36 12 35 9 13 5 10 3 5 0 0.188 0.994 1.000 357 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(4), AP2M1(1), DNM1(2), EPN1(1), EPS15(2), NME1(1), PICALM(1), PPP3CA(2), PPP3CC(1), SYNJ1(1), SYNJ2(3), SYT1(2) 4944769 21 8 21 7 4 5 3 4 4 1 0.411 0.995 1.000 358 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 DHCR7(1), FDFT1(2), FDPS(1), GGCX(2), HMGCR(5), IDI1(1), LSS(1), MVD(2), MVK(1), NSDHL(2), SQLE(2), VKORC1(3) 4306138 23 9 22 7 8 6 6 1 2 0 0.283 0.995 1.000 359 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ARHGAP4(1), ARHGAP5(5), ARHGAP6(3), ARHGEF1(2), ARHGEF11(6), ARHGEF5(2), ARPC1A(1), ARPC2(1), BAIAP2(3), DIAPH1(7), GSN(4), MYLK(13), PIP5K1B(2), ROCK1(5), SRC(2), TLN1(12), VCL(1) 10211844 70 27 67 18 19 17 11 9 13 1 0.0799 0.995 1.000 360 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 75 ACTB(1), ACTN1(1), ACTN2(4), ACVR1B(2), ACVR1C(1), BAIAP2(3), CDC42(1), CDH1(1), CREBBP(3), CSNK2A1(1), CTNNA1(4), CTNNA2(5), CTNNA3(5), CTNNB1(7), CTNND1(2), EGFR(2), EP300(6), ERBB2(6), FARP2(3), FER(7), FGFR1(1), IGF1R(6), INSR(4), IQGAP1(2), LEF1(2), LMO7(4), MAP3K7(2), MET(4), MLLT4(4), NLK(2), PARD3(4), PTPN6(4), PTPRB(10), PTPRF(4), PTPRJ(2), PTPRM(6), PVRL1(2), PVRL2(1), PVRL3(1), RAC2(1), RHOA(1), SMAD2(1), SMAD4(32), SORBS1(2), SRC(2), SSX2IP(3), TCF7(1), TCF7L1(4), TCF7L2(1), TGFBR1(8), TGFBR2(10), TJP1(6), VCL(1), WASF1(1), WASF2(1), WASF3(1), WASL(2), YES1(1) 26540233 209 74 205 35 57 37 30 37 47 1 1.49e-05 0.995 1.000 361 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(2), PSMA2(1), PSMA5(1), PSMA6(1), PSMB1(1), PSMB4(4), PSMB5(2), PSMB7(1), PSMD1(3), PSMD11(1), PSMD12(2), PSMD2(1) 3510857 20 10 20 9 6 1 4 4 5 0 0.858 0.996 1.000 362 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(1), ELK1(2), EPO(2), EPOR(2), HRAS(1), JAK2(6), MAPK8(2), PLCG1(1), PTPN6(4), SHC1(1), SOS1(2), STAT5A(1) 4795414 25 9 24 5 7 3 4 3 8 0 0.269 0.996 1.000 363 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 ATF1(1), CASP2(3), CHUK(1), CRADD(2), IKBKB(4), MAP2K3(1), MAP2K4(5), MAP2K6(3), MAP3K1(3), MAP4K2(3), MAPK8(2), NFKBIA(1), RELA(2), TNFRSF1A(2), TRADD(1), TRAF2(1) 5452677 35 11 35 10 10 6 8 5 6 0 0.284 0.996 1.000 364 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(1), ACOX3(2), PLA2G1B(1), PLA2G3(1), PLA2G6(4) 2253296 9 4 9 5 2 2 3 1 1 0 0.892 0.996 1.000 365 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOB(2), DLAT(4), ENO1(3), ENO3(1), FBP2(1), GAPDHS(2), GCK(1), GOT1(2), GPI(3), HK1(4), HK2(6), HK3(4), LDHAL6B(2), LDHB(1), PC(3), PCK1(3), PDHA1(2), PDHA2(2), PFKL(2), PFKM(3), PGAM1(2), PGK1(3), PKLR(2), TPI1(3) 9356928 61 24 61 12 24 15 9 4 9 0 0.00894 0.996 1.000 366 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(3), POLR2A(5), POLR2B(4), POLR2E(1), POLR2G(1), POLRMT(2) 3027677 16 9 15 6 8 3 1 2 2 0 0.531 0.996 1.000 367 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(2), FUCA2(1), GLB1(2), HEXA(2), HEXB(2), LCT(5), MANBA(1), NEU4(1) 3721098 16 8 16 7 5 2 4 0 4 1 0.742 0.997 1.000 368 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACAA1(1), ACOX1(1), ACOX3(2), ELOVL2(1), ELOVL6(1), FADS1(1), FASN(6), HADHA(1), HSD17B12(1), SCD(1) 3288556 16 5 16 5 5 3 4 0 3 1 0.256 0.997 1.000 369 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(7), ASAH1(1), CAMP(2), CASP3(2), CERK(1), CREB1(2), CREB5(1), DAG1(1), EPHB2(4), GNAQ(1), ITPKB(3), MAP2K4(5), MAP2K7(3), MAPK8(2), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(4), MAPK9(1) 6451420 42 15 42 9 12 5 7 9 9 0 0.115 0.997 1.000 370 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(1), AKT2(2), AKT3(2), ARHGEF11(6), CDC42(1), DLG4(3), LPA(8), MAP2K4(5), MAP3K1(3), MAP3K5(1), MAPK8(2), NFKB2(1), NFKBIA(1), NFKBIB(1), NFKBIE(1), PDK1(1), PHKA2(5), PIK3CB(1), PLD2(4), PTK2(3), RDX(4), ROCK1(5), ROCK2(2), SRF(1), TBXA2R(1) 10924762 65 28 63 17 12 12 12 14 15 0 0.206 0.997 1.000 371 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 ARSE(1), CARM1(2), CYP11B1(4), CYP11B2(1), CYP19A1(3), HEMK1(1), HSD11B1(1), HSD17B1(1), HSD17B12(1), HSD17B2(2), HSD3B1(2), LCMT1(1), LCMT2(1), METTL2B(2), METTL6(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(2), STS(4), SULT2A1(1), SULT2B1(1), UGT1A1(1), UGT1A10(2), UGT1A4(2), UGT1A6(2), UGT1A7(1), UGT2A3(1), UGT2B10(4), UGT2B15(2), UGT2B17(1), UGT2B28(3), UGT2B4(1) 11073772 58 24 56 13 14 18 11 9 6 0 0.0448 0.997 1.000 372 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT1(2), ACAT2(1), ACOT11(1), DHRS1(1), DHRS2(2), DHRS3(2), EHHADH(1), ESCO1(3), GCDH(2), HADHA(1), SH3GLB1(1) 5725631 17 7 17 5 4 3 3 3 4 0 0.485 0.997 1.000 373 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(1), ABCC2(3), ABCG2(1), BCHE(6), CES1(2), CYP3A5(1), UGT1A1(1), UGT1A10(2), UGT1A4(2), UGT1A6(2), UGT1A7(1) 4986405 22 13 22 6 3 5 3 5 4 2 0.429 0.997 1.000 374 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(2), ACACA(4), ACADL(2), ACADM(1), ACADSB(3), ACAT1(2), ACAT2(1), ALDH1A1(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(1), ALDH6A1(1), EHHADH(1), HADHA(1), LDHB(1), MCEE(1), MUT(2), SUCLA2(1), SUCLG1(3) 7287575 31 11 31 6 7 7 5 6 6 0 0.159 0.997 1.000 375 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 131 ACACA(4), ACACB(7), AKT1(1), AKT2(2), AKT3(2), ARAF(2), BAD(1), BRAF(3), CALML3(1), CBL(3), CBLB(2), CRK(1), CRKL(1), ELK1(2), EXOC7(1), FASN(6), FBP2(1), FLOT2(1), G6PC2(1), GCK(1), GSK3B(2), GYS1(3), GYS2(2), HRAS(1), IKBKB(4), INPP5D(1), INSR(4), IRS1(4), IRS2(4), IRS4(16), KRAS(126), LIPE(2), MAPK8(2), MAPK9(1), MKNK2(1), PCK1(3), PCK2(2), PDE3A(8), PDE3B(2), PFKL(2), PFKM(3), PHKA2(5), PHKB(3), PHKG1(2), PIK3CA(4), PIK3CB(1), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PKLR(2), PPARGC1A(2), PPP1CA(1), PPP1R3A(4), PPP1R3C(2), PPP1R3D(1), PRKAA1(2), PRKAA2(1), PRKAB1(1), PRKAB2(2), PRKACB(1), PRKACG(3), PRKAG3(4), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PRKCI(4), PTPRF(4), PYGL(2), PYGM(1), RHEB(1), RPS6KB2(1), SHC1(1), SHC2(2), SHC4(1), SOCS4(2), SORBS1(2), SOS1(2), SOS2(1), TRIP10(1), TSC1(2), TSC2(6) 36086943 326 132 192 76 63 96 85 33 47 2 1.53e-05 0.998 1.000 376 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(3), CAPN1(1), CAPNS1(2), CAPNS2(2), EGF(5), EGFR(2), HRAS(1), ITGA1(7), MYLK(13), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PTK2(3), PXN(1), TLN1(12) 7306135 60 20 59 10 22 15 7 7 8 1 0.00319 0.998 1.000 377 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSA(1), ARSE(1), ASAH1(1), CERK(1), DEGS1(1), ENPP7(7), GAL3ST1(1), GALC(2), GBA(3), GLB1(2), LCT(5), NEU4(1), PPAP2B(2), PPAP2C(1), SGMS1(1), SGPP1(2), SMPD1(2), SMPD3(1), SMPD4(3), SPHK1(1), SPTLC1(3), SPTLC2(1), UGCG(1), UGT8(1) 8034516 45 20 43 14 18 9 4 7 6 1 0.121 0.998 1.000 378 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARF1(1), ARFGAP1(2), ARFGEF2(3), CLTB(1), COPA(3), GBF1(3), GPLD1(2), KDELR2(1) 3565345 16 5 16 4 4 3 3 4 1 1 0.307 0.998 1.000 379 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 AKT1(1), BAD(1), CASP9(1), CDC42(1), CHUK(1), ELK1(2), HRAS(1), PIK3CA(4), PIK3R1(1), RALBP1(2), RALGDS(1), RELA(2), RHOA(1) 4287574 19 9 19 7 3 4 4 5 3 0 0.731 0.998 1.000 380 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(2), HRAS(1), IL3RA(2), JAK2(6), PTPN6(4), SHC1(1), SOS1(2), STAT5A(1) 3912203 19 8 18 6 6 2 3 3 5 0 0.617 0.999 1.000 381 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ADH1A(3), ADH1B(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(4), ALDH1A3(2), ALDH3A1(1), ALDH3B1(2), ALDH3B2(1), AOC2(2), AOC3(3), AOX1(2), DBH(1), DCT(2), DDC(1), GOT1(2), HGD(2), HPD(3), TAT(1), TH(1), TPO(7), TYR(4) 7026328 51 15 51 17 22 8 9 6 5 1 0.206 0.999 1.000 382 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG2(3), ADCY3(6), ADCY9(4), ARF1(1), ARF3(1), ARF4(1), ARL4D(2), ATP6V0A1(3), ATP6V0A2(1), ATP6V0A4(4), ATP6V0C(1), ATP6V0D2(1), ATP6V1C2(1), ATP6V1F(1), ATP6V1H(1), ERO1L(1), GNAS(12), PDIA4(1), PLCG1(1), PLCG2(7), SEC61A1(1), SEC61A2(2), SEC61B(1), SEC61G(1) 8223469 58 20 53 15 22 11 11 6 8 0 0.111 0.999 1.000 383 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(3), AGPAT1(1), AGPAT3(2), AGPAT4(3), AGPS(1), CDIPT(3), CHAT(4), CPT1B(5), DGKA(1), DGKB(2), DGKD(2), DGKG(1), DGKH(3), DGKQ(3), DGKZ(3), GPD1(1), GPD2(1), PAFAH1B1(1), PAFAH2(2), PCYT1A(2), PCYT1B(1), PLA2G1B(1), PLA2G3(1), PLA2G6(4), PLCB2(4), PLCG1(1), PLCG2(7), PPAP2B(2), PPAP2C(1) 11236203 66 20 66 19 21 8 15 10 12 0 0.188 0.999 1.000 384 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 AKT1(1), CABIN1(3), CAMK1(2), CAMK1G(2), HDAC5(2), IGF1R(6), INSR(4), MAP2K6(3), MAPK7(4), MEF2A(1), MEF2C(3), MEF2D(2), NFATC1(4), NFATC2(3), PIK3CA(4), PIK3R1(1), PPP3CA(2), PPP3CC(1), SYT1(2), YWHAH(1) 7749613 51 17 51 13 14 10 8 7 11 1 0.0831 0.999 1.000 385 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(3), CSF1R(1), EGF(5), EGFR(2), MET(4), PDGFRA(3), SH3GLB1(1), SRC(2) 4268259 21 7 21 4 4 7 5 3 2 0 0.158 0.999 1.000 386 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 AKT1(1), CCNE1(1), CDK4(2), CDK6(2), HRAS(1), NFKBIA(1), PIK3CA(4), PIK3R1(1), RB1(3), RELA(2), TFDP1(1) 4491226 19 8 19 8 3 3 6 5 2 0 0.844 0.999 1.000 387 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 HLA-A(2), KLRC3(2), PIK3CA(4), PIK3R1(1), PTPN6(4), SYK(2), VAV1(4) 4102692 19 8 19 8 6 2 4 5 1 1 0.747 0.999 1.000 388 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAD(1), CASP8(2), MAP2K4(5), MAP3K1(3), MAPK8(2), NSMAF(1), RELA(2), SMPD1(2), TNFRSF1A(2), TRADD(1), TRAF2(1) 4590463 22 9 22 8 6 1 5 4 6 0 0.768 0.999 1.000 389 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 CHUK(1), IKBKB(4), MAP3K1(3), MAP3K5(1), MAP4K5(1), MAPK8(2), NFKBIA(1), RELA(2), TNFRSF9(1), TRAF2(1) 4356040 17 6 17 7 2 3 4 4 4 0 0.772 0.999 1.000 390 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(1), POLD1(2), POLD2(1), POLE(8), POLG(4), POLL(2), POLQ(3) 3719114 21 5 21 3 7 5 5 1 3 0 0.0705 0.999 1.000 391 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 ASNS(3), CA5B(1), CA6(1), CA8(1), CA9(1), CPS1(4), GLS(1), HAL(1) 4192355 13 3 13 4 3 5 1 1 2 1 0.557 0.999 1.000 392 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(1), ATP6V0A1(3), ATP6V0A4(4), ATP6V0C(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1F(1), ATP6V1H(1), SHMT1(1) 3329772 15 6 15 4 3 4 6 1 1 0 0.338 0.999 1.000 393 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(1), ATP6V0A1(3), ATP6V0A4(4), ATP6V0C(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1F(1), ATP6V1H(1), SHMT1(1) 3329772 15 6 15 4 3 4 6 1 1 0 0.338 0.999 1.000 394 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(1), ATP6V0A1(3), ATP6V0A4(4), ATP6V0C(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1F(1), ATP6V1H(1), SHMT1(1) 3329772 15 6 15 4 3 4 6 1 1 0 0.338 0.999 1.000 395 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(4), COL4A2(6), COL4A3(2), COL4A4(4), COL4A5(3), COL4A6(4), SLC2A1(3), SLC2A3(1) 5602560 27 10 27 7 5 5 11 2 3 1 0.423 0.999 1.000 396 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG2(3), AKT1(1), ANGPTL2(1), CDC42(1), FLNA(10), FLNC(10), FSCN1(1), FSCN3(2), GDI1(1), GDI2(3), MYH2(3), MYLK(13), MYLK2(4), PAK2(2), PAK4(1), PAK6(1), PAK7(2), ROCK1(5), ROCK2(2), WASF1(1), WASL(2) 10735657 69 31 68 20 18 13 15 12 10 1 0.195 0.999 1.000 397 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS1(1), DHRS2(2), DHRS3(2), ESCO1(3), SH3GLB1(1) 3648848 9 4 9 4 2 1 1 3 2 0 0.793 0.999 1.000 398 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(11), C5(2), C6(6), C7(4), ICAM1(2), IL6(1), ITGA4(1), ITGAL(2), ITGB2(1), SELP(2), SELPLG(1) 5451277 33 14 33 12 10 8 5 2 8 0 0.414 0.999 1.000 399 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(1), ALDOB(2), FBP2(1), FPGT(1), FUK(1), GMDS(1), GMPPA(3), HK1(4), HK2(6), HK3(4), HSD3B7(3), MTMR2(2), MTMR6(2), PFKFB1(2), PFKFB2(1), PFKFB3(1), PFKFB4(2), PFKL(2), PFKM(3), PGM2(1), PHPT1(1), PMM2(2), RDH11(2), TPI1(3), TSTA3(1) 8300064 52 22 52 15 20 7 13 5 7 0 0.238 0.999 1.000 400 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA1(1), ACADL(2), ACADM(1), ACADS(1), ACADSB(3), ACAT1(2), ACAT2(1), ALDH1A1(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(1), ALDH6A1(1), AOX1(2), BCAT1(1), BCKDHA(1), BCKDHB(1), EHHADH(1), HADHA(1), HADHB(2), HIBADH(2), MCCC1(3), MCCC2(2), MCEE(1), MUT(2), OXCT1(2) 7941114 38 12 38 6 8 10 7 3 10 0 0.0336 0.999 1.000 401 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(1), DLG4(3), EPHB2(4), F2RL1(2), F2RL2(2), F2RL3(1), MAPK7(4), MAPK8(2), MYEF2(2), PLD2(4), PTK2(3), RASAL1(4), SRC(2), TEC(2), VAV1(4) 6139534 40 9 39 12 12 12 6 3 6 1 0.177 0.999 1.000 402 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(1), ATF1(1), CDC42(1), CREB1(2), CREB5(1), DUSP10(2), ELK1(2), MAP2K3(1), MAP2K4(5), MAP2K6(3), MAP3K10(2), MAP3K4(2), MAP3K5(1), MAP3K7(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPKAPK5(1), MKNK2(1), MYEF2(2), NR2C2(1), SRF(1), TRAF6(1) 7522489 36 20 36 11 7 5 8 5 11 0 0.510 0.999 1.000 403 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD9(2), ADH1A(3), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(4), DHRS1(1), DHRS2(2), DHRS3(2), ESCO1(3), SH3GLB1(1) 5502769 27 7 27 9 8 7 2 5 5 0 0.461 0.999 1.000 404 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AOC2(2), AOC3(3), CES1(2), DDHD1(3), ESCO1(3), LIPA(1), PLA1A(2), SH3GLB1(1) 5595333 17 8 17 5 5 3 5 3 1 0 0.423 0.999 1.000 405 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6AP1(1), ATP6V0A1(3), ATP6V0A4(4), ATP6V0C(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1F(1), ATP6V1H(1), SHMT1(1) 3541871 15 6 15 5 3 4 6 1 1 0 0.456 0.999 1.000 406 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(2), CD38(2), ENPP3(3), NADSYN1(4), NNT(5), NT5C1B(2), NT5C2(1), NT5E(1), NT5M(1), NUDT12(1) 4765188 22 6 22 8 6 4 7 3 2 0 0.549 0.999 1.000 407 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 CHUK(1), IKBKAP(3), IKBKB(4), MAP3K1(3), NFKBIA(1), RELA(2), TNFAIP3(2), TRAF6(1) 4035712 17 5 17 7 2 5 6 2 2 0 0.753 0.999 1.000 408 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CD14(1), CHUK(1), ELK1(2), IKBKB(4), LY96(1), MAP2K3(1), MAP2K4(5), MAP2K6(3), MAP3K1(3), MAP3K7(2), MAPK8(2), NFKBIA(1), PPARA(1), RELA(2), TLR2(3), TLR3(2), TLR4(1), TLR6(4), TLR9(6), TRAF6(1) 8121143 46 17 46 14 11 6 7 10 12 0 0.476 0.999 1.000 409 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(4), ACACB(7), ACAT1(2), ACAT2(1), ACOT12(4), ACSS2(1), AKR1B1(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(1), DLAT(4), GLO1(2), GRHPR(1), HAGH(2), LDHAL6A(1), LDHAL6B(2), LDHB(1), ME1(2), ME2(6), ME3(1), PC(3), PCK1(3), PCK2(2), PDHA1(2), PDHA2(2), PKLR(2) 10307851 60 22 60 13 16 20 6 4 12 2 0.0316 0.999 1.000 410 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ALDH1A3(2), ALDH3A1(1), ALDH3B1(2), ALDH3B2(1), AOC2(2), AOC3(3), DDC(1), EPX(4), ESCO1(3), GOT1(2), HPD(3), LPO(5), MPO(2), SH3GLB1(1), TAT(1), TPO(7) 7573766 40 13 40 8 19 6 7 5 3 0 0.0296 0.999 1.000 411 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(7), MAP2(5), PPP1CA(1), PPP2CA(1), PRKACB(1), PRKACG(3), PRKAR2B(1), PRKCE(1) 3997752 20 6 20 9 6 4 3 5 2 0 0.836 1.000 1.000 412 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(3), ADH1B(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(4), AKR1A1(1), ALDH1A1(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(1), ALDH3B1(2), ALDH3B2(1), ALDOB(2), BPGM(1), DLAT(4), ENO1(3), ENO3(1), FBP2(1), GCK(1), GPI(3), HK1(4), HK2(6), HK3(4), LDHB(1), PDHA1(2), PDHA2(2), PFKM(3), PGAM1(2), PGK1(3), PGM1(1), PKLR(2), TPI1(3) 10771003 72 23 72 18 32 15 8 5 12 0 0.0341 1.000 1.000 413 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(3), ADH1B(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(4), AKR1A1(1), ALDH1A1(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(1), ALDH3B1(2), ALDH3B2(1), ALDOB(2), BPGM(1), DLAT(4), ENO1(3), ENO3(1), FBP2(1), GCK(1), GPI(3), HK1(4), HK2(6), HK3(4), LDHB(1), PDHA1(2), PDHA2(2), PFKM(3), PGAM1(2), PGK1(3), PGM1(1), PKLR(2), TPI1(3) 10771003 72 23 72 18 32 15 8 5 12 0 0.0341 1.000 1.000 414 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 BLVRA(2), CP(3), CPOX(1), EPRS(1), GUSB(1), HMBS(1), HMOX2(1), PPOX(1), UGT1A1(1), UGT1A10(2), UGT1A4(2), UGT1A6(2), UGT1A7(1), UGT2B15(2), UGT2B4(1) 5994760 22 9 22 3 4 6 1 6 5 0 0.102 1.000 1.000 415 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ALDH1A1(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(1), ALDH3B1(2), ALDH3B2(1), AOC2(2), AOC3(3), ASPA(1), DDC(1), HAL(1), PRPS1(1) 5404257 17 9 17 5 8 4 3 2 0 0 0.250 1.000 1.000 416 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ALDH18A1(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(1), AMD1(1), AOC2(2), AOC3(3), ARG1(1), ARG2(1), ASL(2), ASS1(1), CPS1(4), ODC1(1), SAT2(1) 6562373 22 8 22 3 10 4 3 2 2 1 0.0345 1.000 1.000 417 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(2), FUCA2(1), GLB1(2), HEXA(2), HEXB(2), LCT(5), MAN2B1(1), MAN2B2(2), MANBA(1), NEU4(1) 4578523 19 9 19 9 7 2 5 0 4 1 0.758 1.000 1.000 418 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOB(2), FBP2(1), GPI(3), H6PD(6), PFKL(2), PFKM(3), PGD(1), PGLS(1), PGM1(1), PRPS1(1), PRPS1L1(3), RBKS(1), RPE(2), RPIA(1), TKT(1) 5400825 29 10 29 8 11 5 8 3 2 0 0.154 1.000 1.000 419 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(2), ACACA(4), ACACB(7), ACADM(1), ACAT1(2), ACAT2(1), ACSS2(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(1), ALDH6A1(1), EHHADH(1), HADHA(1), LDHAL6A(1), LDHAL6B(2), LDHB(1), MCEE(1), MUT(2), SUCLA2(1), SUCLG1(3) 8733223 36 11 36 9 10 8 6 5 7 0 0.242 1.000 1.000 420 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 ALDH1A1(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(1), ALDH4A1(3), AMD1(1), AOC2(2), AOC3(3), ARG1(1), ARG2(1), ASL(2), CKB(1), CKM(3), CKMT1A(1), CKMT1B(1), CKMT2(2), CPS1(4), DAO(2), GOT1(2), NOS1(7), NOS3(8), OAT(2), ODC1(1), P4HA1(4), P4HA2(1), P4HA3(1), PYCR1(1), RARS(1) 9836916 60 20 60 8 25 10 15 6 3 1 0.000870 1.000 1.000 421 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP5(1), ACPT(1), ALPI(2), ALPL(2), ALPP(3), ALPPL2(4), CYP19A1(3), CYP1A1(2), CYP1A2(4), CYP2A13(2), CYP2A6(2), CYP2A7(2), CYP2B6(1), CYP2C18(3), CYP2C9(2), CYP2D6(2), CYP2E1(1), CYP2F1(2), CYP2J2(4), CYP3A5(1), CYP3A7(2), CYP4B1(1), PON1(1) 6489338 48 17 47 15 19 6 10 7 6 0 0.229 1.000 1.000 422 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(3), AR(2), ESR1(1), ESR2(2), ESRRA(2), NPM1(1), NR0B1(3), NR1D2(1), NR1H3(3), NR1I2(1), NR1I3(1), NR2C2(1), NR2E1(2), NR2F1(2), NR2F2(2), NR2F6(1), NR3C1(2), NR4A1(3), NR4A2(3), NR5A2(1), PGR(4), PPARA(1), PPARD(1), PPARG(1), RARB(1), RARG(2), ROR1(2), RORA(1), RORC(1), RXRA(1), RXRB(2), RXRG(1), THRA(1), THRB(1) 9479536 57 19 57 17 18 14 10 6 9 0 0.0918 1.000 1.000 423 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT1(1), AKT2(2), AKT3(2), CISH(1), IARS(4), IL4R(3), INPP5D(1), JAK1(1), JAK2(6), JAK3(3), PIK3CA(4), SHC1(1), SOS1(2), SOS2(1), SRC(2), STAT6(5), TYK2(2) 8215085 41 17 40 12 9 7 7 8 10 0 0.467 1.000 1.000 424 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 EIF2B1(1), EIF2B2(2), EIF2B3(1), EIF2B5(1), ELAVL1(1), FLT1(3), FLT4(9), HIF1A(1), HRAS(1), KDR(1), NOS3(8), PIK3CA(4), PIK3R1(1), PLCG1(1), PTK2(3), PXN(1), SHC1(1) 7562406 40 17 40 12 13 9 10 3 5 0 0.292 1.000 1.000 425 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 GOT1(2), LDHB(1) 1511778 3 1 3 2 1 0 1 1 0 0 0.935 1.000 1.000 426 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 42 CD3E(1), ELK1(2), HRAS(1), LCK(1), MAP2K4(5), MAP3K1(3), MAPK8(2), NFATC1(4), NFATC2(3), NFATC3(2), NFATC4(5), NFKBIA(1), PIK3CA(4), PIK3R1(1), PLCG1(1), PPP3CA(2), PPP3CC(1), RASA1(2), RELA(2), SHC1(1), SOS1(2), SYT1(2), VAV1(4), ZAP70(6) 10617358 58 16 58 14 14 14 7 11 10 2 0.112 1.000 1.000 427 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 CANX(1), CD4(2), CD8B(2), CREB1(2), CTSB(2), CTSS(2), HLA-A(2), HLA-DMB(1), HLA-DPA1(1), HLA-DQA2(1), HLA-DRB5(1), HLA-F(1), HLA-G(2), HSP90AA1(2), HSP90AB1(2), HSPA5(4), IFI30(1), IFNA10(1), IFNA16(1), IFNA7(2), KIR2DL3(2), KIR3DL1(2), KLRC3(2), LGMN(1), NFYC(1), PDIA3(2), RFX5(1), TAP1(4), TAP2(1), TAPBP(1) 10352013 50 21 50 15 8 13 7 11 11 0 0.315 1.000 1.000 428 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CHUK(1), CREBBP(3), EP300(6), IKBKB(4), NFKBIA(1), RELA(2), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF6(1) 5006368 22 10 22 9 6 4 6 2 4 0 0.717 1.000 1.000 429 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS2(1), ADH1A(3), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(4), AKR1A1(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(1), ALDH3B1(2), ALDH3B2(1), ALDOB(2), BPGM(1), DLAT(4), ENO1(3), ENO3(1), FBP2(1), G6PC2(1), GAPDHS(2), GCK(1), GPI(3), HK1(4), HK2(6), HK3(4), LDHAL6A(1), LDHAL6B(2), LDHB(1), PDHA1(2), PDHA2(2), PFKL(2), PFKM(3), PGAM1(2), PGAM4(2), PGK1(3), PGM1(1), PKLR(2), TPI1(3) 12852528 84 27 84 22 35 20 10 5 14 0 0.0292 1.000 1.000 430 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(3), POLR1B(3), POLR2A(5), POLR2B(4), POLR2E(1), POLR2G(1), POLR3A(1), POLR3B(3), POLR3G(1) 5143197 22 12 21 9 9 3 4 2 4 0 0.726 1.000 1.000 431 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 SEC61A2(2), SRP54(1), SRP68(4), SRP72(1), SRPR(1) 1649687 9 1 9 0 3 4 2 0 0 0 0.0535 1.000 1.000 432 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(1), CAMP(2), DAG1(1), GNAQ(1), ITPKB(3) 1371427 8 1 8 1 3 0 1 2 2 0 0.215 1.000 1.000 433 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 AKT1(1), APC(7), AR(2), ASAH1(1), BRAF(3), CAMP(2), CCL16(1), DAG1(1), EGFR(2), GNA11(2), GNA15(3), GNAI1(1), GNAQ(1), ITPKB(3), ITPR1(10), ITPR2(4), ITPR3(8), KCNJ5(1), PHKA2(5), PIK3CA(4), PIK3CD(2), PIK3R1(1), SRC(2) 11948780 67 24 67 13 21 9 15 11 11 0 0.0237 1.000 1.000 434 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(5), ACTB(1), ARPC5(1), ARPC5L(1), CD14(1), CDC42(1), CDH1(1), CTNNB1(7), CTTN(2), HCLS1(1), LY96(1), NCK1(4), NCK2(2), RHOA(1), ROCK1(5), ROCK2(2), TLR4(1), TLR5(2), TUBA1A(2), TUBA1B(1), TUBA3C(3), TUBA3D(3), TUBA3E(4), TUBA8(4), TUBAL3(1), TUBB1(3), TUBB2B(1), TUBB3(2), TUBB6(1), TUBB8(2), WASL(2) 11624431 68 22 68 16 25 16 8 13 6 0 0.0216 1.000 1.000 435 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(5), ACTB(1), ARPC5(1), ARPC5L(1), CD14(1), CDC42(1), CDH1(1), CTNNB1(7), CTTN(2), HCLS1(1), LY96(1), NCK1(4), NCK2(2), RHOA(1), ROCK1(5), ROCK2(2), TLR4(1), TLR5(2), TUBA1A(2), TUBA1B(1), TUBA3C(3), TUBA3D(3), TUBA3E(4), TUBA8(4), TUBAL3(1), TUBB1(3), TUBB2B(1), TUBB3(2), TUBB6(1), TUBB8(2), WASL(2) 11624431 68 22 68 16 25 16 8 13 6 0 0.0216 1.000 1.000 436 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ALDH1A3(2), ALDH3A1(1), ALDH3A2(1), ALDH3B1(2), ALDH3B2(1), AOC2(2), AOC3(3), ASPA(1), CARM1(2), DDC(1), FTCD(2), HAL(1), HEMK1(1), LCMT1(1), LCMT2(1), METTL2B(2), METTL6(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(2), PRPS1(1), UROC1(3) 8796791 37 13 37 9 11 10 10 4 2 0 0.0853 1.000 1.000 437 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(3), CARM1(2), CREBBP(3), EP300(6), ERCC3(3), ESR1(1), GRIP1(1), GTF2A1(1), GTF2E1(2), GTF2F1(1), HDAC4(4), HDAC5(2), HDAC6(1), MEF2C(3), NCOR2(3), NR0B1(3), NRIP1(2), POLR2A(5), TBP(1) 10464133 47 21 47 12 14 8 11 6 8 0 0.154 1.000 1.000 438 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(2), ACAA1(1), ACADM(1), ACADS(1), ACAT1(2), ACAT2(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(1), ALDH6A1(1), AOX1(2), AUH(1), BCAT1(1), BCAT2(2), BCKDHA(1), BCKDHB(1), DBT(3), EHHADH(1), HADH(1), HADHA(1), HADHB(2), HIBADH(2), HMGCS2(2), HSD17B4(3), MCCC1(3), MCCC2(2), MCEE(1), MUT(2), OXCT1(2), OXCT2(1) 9522404 47 16 47 10 12 9 10 4 12 0 0.0964 1.000 1.000 439 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(4), ACACB(7), FASN(6), MCAT(1), OXSM(1) 3612743 19 3 19 5 7 5 4 1 1 1 0.150 1.000 1.000 440 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 31 AKT1(1), AKT2(2), AKT3(2), APC(7), AXIN1(3), AXIN2(1), CTNNB1(7), DACT1(4), DKK2(1), DKK3(1), DKK4(1), DVL1(4), GSK3A(1), GSK3B(2), LRP1(15), MVP(2), NKD1(4), PSEN1(1), PTPRA(1), SENP2(1), SFRP1(2), WIF1(2) 9101459 65 24 65 14 24 13 11 12 5 0 0.0197 1.000 1.000 441 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(5), EGFR(2), MAP3K1(3), NCOR2(3), RXRA(1), THRA(1), THRB(1) 3880008 16 7 16 9 2 5 5 2 2 0 0.904 1.000 1.000 442 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(1), POLA2(1), POLB(1), POLD1(2), POLD2(1), POLE(8), POLE2(5), POLG(4), POLH(1), POLI(2), POLK(3), POLL(2), POLM(1), POLQ(3), PRIM1(1), REV1(1), REV3L(5) 9069477 42 12 40 6 8 7 9 8 10 0 0.0702 1.000 1.000 443 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 51 ACTA1(3), AGT(1), AKT1(1), CAMK1(2), CAMK1G(2), CAMK4(1), CREBBP(3), EDN1(1), ELSPBP1(2), FKBP1A(1), GATA4(1), GSK3B(2), HAND2(1), HRAS(1), LIF(1), MAPK8(2), MEF2C(3), MYH2(3), NFATC1(4), NFATC2(3), NFATC3(2), NFATC4(5), NKX2-5(1), PIK3CA(4), PIK3R1(1), PPP3CA(2), PPP3CC(1), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), SYT1(2) 11267060 64 18 64 15 22 12 12 9 8 1 0.0337 1.000 1.000 444 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 MRPS7(1), RPL10A(1), RPL10L(2), RPL11(1), RPL12(1), RPL14(1), RPL18(2), RPL18A(1), RPL19(1), RPL22L1(1), RPL28(2), RPL32(1), RPL34(1), RPL35(1), RPL36AL(1), RPL3L(2), RPL6(1), RPS11(2), RPS12(1), RPS25(1), RPS27(1), RPS28(1), RPSA(1) 5045008 28 13 28 7 8 3 9 0 8 0 0.369 1.000 1.000 445 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 BTK(1), ELK1(2), FCER1A(1), HRAS(1), MAP2K4(5), MAP2K7(3), MAP3K1(3), MAPK8(2), NFATC1(4), NFATC2(3), NFATC3(2), NFATC4(5), PAK2(2), PIK3CA(4), PIK3R1(1), PLCG1(1), PPP3CA(2), PPP3CC(1), SHC1(1), SOS1(2), SYK(2), SYT1(2), VAV1(4) 9519845 54 14 54 15 13 13 7 11 8 2 0.228 1.000 1.000 446 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(1), AP2M1(1), ARF1(1), BAD(1), BTK(1), EEA1(3), GRASP(1), GSK3A(1), GSK3B(2), PFKL(2), PFKM(3), PLCG1(1), PRKCE(1) 5667293 19 5 19 6 4 8 3 2 2 0 0.274 1.000 1.000 447 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA1(1), ACADL(2), ACADM(1), ACADS(1), ACADSB(3), ACAT1(2), ACAT2(1), ACOX1(1), ACOX3(2), ACSL1(1), ACSL3(4), ACSL4(3), ACSL5(2), ACSL6(2), ADH1A(3), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(4), ALDH1A3(2), ALDH3A1(1), ALDH3A2(1), CPT1A(1), CPT1B(5), CPT1C(2), CPT2(1), CYP4A22(1), EHHADH(1), GCDH(2), HADH(1), HADHA(1), HADHB(2), HSD17B4(3) 10789272 66 19 66 13 22 17 9 7 11 0 0.00740 1.000 1.000 448 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(2), ALPL(2), ALPP(3), ALPPL2(4), DHFR(1), FPGS(3), GCH1(1), GGH(2) 1498144 18 4 18 3 7 7 0 2 2 0 0.0217 1.000 1.000 449 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 GNAQ(1), NFKBIA(1), PLCB1(1), RELA(2) 1824847 5 2 5 3 1 1 1 1 1 0 0.906 1.000 1.000 450 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(4), CYP2A13(2), CYP2A6(2), CYP2A7(2), NAT2(1), XDH(5) 1742972 16 6 16 7 8 1 1 4 2 0 0.690 1.000 1.000 451 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 50 ACOX1(1), CITED2(1), CPT1B(5), CREBBP(3), DUT(1), EHHADH(1), EP300(6), HSD17B4(3), LPL(3), ME1(2), NCOR1(11), NCOR2(3), NFKBIA(1), NR1H3(3), NR2F1(2), NRIP1(2), PIK3CA(4), PIK3R1(1), PPARA(1), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), RB1(3), RELA(2), RXRA(1), SP1(1), STAT5A(1) 14077897 70 24 70 19 21 16 12 10 11 0 0.103 1.000 1.000 452 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CCL3(1), EPO(2), FLT3(3), IL6(1), IL9(1), TGFB1(1) 1849465 9 3 9 2 2 2 4 1 0 0 0.347 1.000 1.000 453 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT1(1), AKT2(2), AKT3(2), ASAH1(1), BRAF(3), DAG1(1), EGFR(2), EPHB2(4), ITPKB(3), ITPR1(10), ITPR2(4), ITPR3(8), KCNJ5(1), PIK3CB(1), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), SHC1(1), SOS1(2), SOS2(1), SRC(2), STAT3(2), TERF2IP(1) 13038551 63 21 63 16 19 9 11 11 13 0 0.152 1.000 1.000 454 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2RL3(1), GNAI1(1), GNB1(3), HRAS(1), ITGA1(7), PLCB1(1), PTGS1(1), PTK2(3), SRC(2), SYK(2), TBXAS1(1) 5396162 23 6 23 9 6 8 2 4 3 0 0.691 1.000 1.000 455 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAS1(1), ALAS2(3), BLVRA(2), COX15(1), CP(3), CPOX(1), EARS2(1), EPRS(1), FTMT(3), GUSB(1), HMBS(1), HMOX2(1), PPOX(1), UGT1A1(1), UGT1A10(2), UGT1A4(2), UGT1A6(2), UGT1A7(1), UGT2A3(1), UGT2B10(4), UGT2B15(2), UGT2B17(1), UGT2B28(3), UGT2B4(1) 9263720 40 16 39 8 8 13 2 9 8 0 0.0820 1.000 1.000 456 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2D(1), DAG1(1), ITPKB(3), ITPR1(10), ITPR2(4), ITPR3(8), NFAT5(4), PDE6B(3), PDE6C(1), SLC6A13(1) 7991713 36 10 36 7 13 7 8 2 6 0 0.0470 1.000 1.000 457 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 A4GALT(1), B3GALT1(1), B3GALT2(2), B3GALT4(2), B3GNT2(2), B3GNT3(1), B3GNT4(1), B3GNT5(1), B4GALNT1(1), B4GALT2(1), FUT2(2), FUT4(1), FUT5(1), FUT6(2), FUT9(1), GBGT1(1), GCNT2(1), PIGB(2), PIGC(1), PIGG(2), PIGL(2), PIGM(1), PIGO(4), PIGQ(6), PIGS(3), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2), ST3GAL5(1), ST6GALNAC3(2), ST6GALNAC4(1), ST6GALNAC5(3), ST6GALNAC6(2), ST8SIA1(2), ST8SIA5(3), UGCG(1) 10888579 63 25 63 12 20 13 16 6 8 0 0.00445 1.000 1.000 458 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(2), AGT(1), EDN1(1), EDNRB(2), EGF(5), EGFR(2), HRAS(1), PLCG1(1), RELA(2) 4533841 17 5 17 6 3 4 4 1 5 0 0.601 1.000 1.000 459 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(1), IKBKB(4), IL1B(1), IL1RAP(2), IL1RN(1), IL6(1), IRAK3(1), MAP2K3(1), MAP2K6(3), MAP3K1(3), MAP3K7(2), MAPK8(2), NFKBIA(1), RELA(2), TGFB1(1), TRAF6(1) 6613435 27 9 27 9 6 4 5 6 6 0 0.495 1.000 1.000 460 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 APAF1(3), BIRC2(2), CASP2(3), CASP3(2), CASP7(1), CASP8(2), CASP9(1), CFLAR(3), CHUK(1), CRADD(2), DAXX(3), DFFB(1), GSN(4), LMNB2(1), MAP2K7(3), MAP3K1(3), MAP3K5(1), MAPK8(2), MDM2(2), NFKBIA(1), NUMA1(2), PAK2(2), PRKCD(4), PRKDC(7), PSEN1(1), PSEN2(1), PTK2(3), RASA1(2), RB1(3), RELA(2), SPTAN1(4), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(1) 15537234 77 22 75 19 16 11 22 11 17 0 0.158 1.000 1.000 461 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 ATP8A1(3), AVPR1A(1), AVPR1B(1), AVPR2(2), BDKRB2(1), C3AR1(3), CCKAR(4), CCKBR(3), CCR1(1), CCR10(1), CCR2(1), CCR4(3), CCR7(1), CX3CR1(1), CXCR4(3), EDNRB(2), FPR1(2), FSHR(3), GALR1(2), GALR2(1), GNRHR(1), GRPR(1), LHCGR(2), MC2R(2), MC3R(4), MC5R(3), NPY1R(3), NPY2R(2), NPY5R(1), OPRD1(2), OPRK1(2), OPRL1(2), OPRM1(1), OXTR(2), SSTR1(2), SSTR4(3), TACR1(3), TACR2(1), TACR3(2), TRHR(2), TSHR(3) 11608086 83 28 81 29 32 12 19 10 9 1 0.143 1.000 1.000 462 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(4), AMY2A(3), ENPP3(3), GAA(2), GANAB(3), GBE1(4), GCK(1), GPI(3), GUSB(1), GYS1(3), GYS2(2), HK1(4), HK2(6), HK3(4), MGAM(1), PGM1(1), PYGL(2), PYGM(1), SI(5), UGDH(2), UGT1A1(1), UGT1A10(2), UGT1A4(2), UGT1A6(2), UGT1A7(1), UGT2B15(2), UGT2B4(1), UXS1(2) 12615090 68 29 67 19 23 15 8 8 14 0 0.222 1.000 1.000 463 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B4GALT2(1), B4GALT5(2), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2) 1764957 8 3 8 2 3 0 4 1 0 0 0.496 1.000 1.000 464 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(1), CYP2C9(2), DHRS1(1), DHRS2(2), DHRS3(2), EHHADH(1), ESCO1(3), HADHA(1), SH3GLB1(1) 6824087 18 9 18 8 7 2 3 3 3 0 0.723 1.000 1.000 465 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 44 AKT1(1), AKT2(2), AKT3(2), ANGPTL2(1), ARHGAP4(1), ARHGEF11(6), BTK(1), CDC42(1), GDI1(1), GDI2(3), INPPL1(2), ITPR1(10), ITPR2(4), ITPR3(8), MYLK(13), MYLK2(4), PAK2(2), PAK4(1), PAK6(1), PAK7(2), PDK1(1), PIK3CA(4), PIK3CD(2), PIK3CG(4), PIK3R1(1), RACGAP1(3), ROCK1(5), ROCK2(2), SAG(1), WASF1(1), WASL(2) 15643695 92 34 91 27 29 17 18 13 14 1 0.145 1.000 1.000 466 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 70 ADH1A(3), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(4), AKR1C1(1), AKR1C3(2), ALDH1A3(2), ALDH3A1(1), ALDH3B1(2), ALDH3B2(1), CYP1A1(2), CYP1A2(4), CYP1B1(1), CYP2B6(1), CYP2C18(3), CYP2C9(2), CYP2E1(1), CYP2F1(2), CYP2S1(2), CYP3A5(1), CYP3A7(2), EPHX1(2), GSTA2(1), GSTA3(1), GSTA4(1), GSTA5(2), GSTM2(1), GSTM5(2), GSTO2(1), GSTP1(1), MGST2(1), UGT1A1(1), UGT1A10(2), UGT1A4(2), UGT1A6(2), UGT1A7(1), UGT2A3(1), UGT2B10(4), UGT2B15(2), UGT2B17(1), UGT2B28(3), UGT2B4(1) 12708372 79 22 78 22 22 19 14 11 13 0 0.103 1.000 1.000 467 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 65 ADAM10(1), ADAM17(4), ATP6AP1(1), ATP6V0A1(3), ATP6V0A2(1), ATP6V0A4(4), ATP6V0C(1), ATP6V0D2(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1F(1), ATP6V1H(1), CASP3(2), CDC42(1), CHUK(1), CSK(1), EGFR(2), F11R(1), GIT1(3), IGSF5(1), IKBKB(4), JAM2(2), MAP2K4(5), MAPK11(1), MAPK12(1), MAPK13(1), MAPK8(2), MAPK9(1), MET(4), NFKB2(1), NFKBIA(1), NOD1(3), PLCG1(1), PLCG2(7), PTPRZ1(4), RELA(2), SRC(2), TCIRG1(1), TJP1(6) 15609213 82 26 82 17 16 20 18 14 14 0 0.0203 1.000 1.000 468 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 32 MAP2K4(5), MAP2K7(3), MAPK11(1), MAPK12(1), MAPK13(1), MAPK8(2), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(4), MAPK9(1), MAPKAPK5(1), NFKB2(1), NFKBIA(1), NFKBIB(1), NFKBIE(1), PIK3CA(4), PIK3CD(2), PIK3R1(1), SYT1(2), TRAF2(1), TRAF5(1), TRAF6(1) 7676257 37 13 37 12 7 8 8 7 6 1 0.351 1.000 1.000 469 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(2), CARM1(2), GGT1(1), HEMK1(1), LCMT1(1), LCMT2(1), MARS2(2), MAT2B(2), METTL2B(2), METTL6(1), PAPSS1(2), PAPSS2(6), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(2), SCLY(2), SEPHS2(5) 5524346 38 17 36 14 11 9 9 2 7 0 0.537 1.000 1.000 470 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 43 CHUK(1), DAXX(3), EGF(5), EGFR(2), ETS1(2), ETS2(2), HOXA7(1), HRAS(1), IKBKB(4), MAP2K3(1), MAP2K4(5), MAP2K6(3), MAP2K7(3), MAP3K1(3), MAP3K5(1), MAPK13(1), MAPK8(2), NFKBIA(1), PPP2CA(1), PRKCD(4), PRKCE(1), PRKCG(2), PRKCH(1), PRKCQ(2), RELA(2), SP1(1), TNFRSF1A(2), TNFRSF1B(1), TRAF2(1) 10954512 59 22 59 19 14 11 13 11 10 0 0.337 1.000 1.000 471 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(1), CDC7(2), CDT1(1), DIAPH2(1), MCM10(1), MCM2(6), MCM3(4), MCM5(2), MCM6(5), MCM7(1), NACA(8), POLA2(1), POLD1(2), POLD2(1), POLE(8), POLE2(5), PRIM1(1), RFC1(3), RFC2(2), RPA1(1), RPA2(2), RPA3(1), RPS27A(1), UBB(1) 11262089 61 20 59 10 19 7 15 8 11 1 0.0156 1.000 1.000 472 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 CD3E(1), HLA-A(2), ICAM1(2), ITGAL(2), ITGB2(1), PRF1(1) 1915653 9 2 9 3 4 1 1 1 2 0 0.392 1.000 1.000 473 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(3), ACTN1(1), ACTN2(4), BCAR1(2), BCR(2), CAPN1(1), CAPNS1(2), CAPNS2(2), CRKL(1), CSK(1), HRAS(1), ITGA1(7), MAPK8(2), PTK2(3), PXN(1), ROCK1(5), SHC1(1), SOS1(2), SRC(2), TLN1(12), VCL(1), ZYX(1) 10594517 57 17 57 12 21 17 5 6 7 1 0.0147 1.000 1.000 474 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 GNAQ(1), GNAS(12), GNB1(3), HRAS(1), NOX1(2), PLCB1(1), PTK2(3), ROCK2(2) 5646482 25 12 20 9 11 5 3 3 3 0 0.631 1.000 1.000 475 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(3), BAD(1), CASP1(1), CASP10(3), CASP2(3), CASP3(2), CASP4(2), CASP7(1), CASP8(2), CASP9(1), CD40(1), CRADD(2), DAXX(3), DFFB(1), FASLG(1), IKBKE(1), NFKBIA(1), NGFR(1), NR3C1(2), NTRK1(2), PTPN13(4), TFG(2), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(1), TRAF6(1) 9771032 46 11 46 14 12 12 10 5 7 0 0.373 1.000 1.000 476 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(4), AKT1(1), AKT2(2), AKT3(2), DAG1(1), GNAQ(1), ITPKB(3), ITPR1(10), ITPR2(4), ITPR3(8), NFKB2(1), NFKBIA(1), NFKBIB(1), NFKBIE(1), PDK1(1), PHKA2(5), PIK3CB(1), PLD2(4), VN1R1(1) 10048939 52 20 51 13 18 10 9 6 9 0 0.101 1.000 1.000 477 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACAA1(1), ACADL(2), ACADM(1), ACOX1(1), ACOX2(1), ACOX3(2), ACSL1(1), ACSL3(4), ACSL4(3), ACSL5(2), ACSL6(2), ANGPTL4(1), APOA5(3), AQP7(7), CPT1A(1), CPT1B(5), CPT1C(2), CPT2(1), CYP27A1(2), CYP4A22(1), CYP7A1(2), CYP8B1(2), EHHADH(1), FABP4(1), GK2(4), HMGCS2(2), ILK(1), LPL(3), ME1(2), MMP1(1), NR1H3(3), PCK1(3), PCK2(2), PLTP(1), PPARA(1), PPARD(1), PPARG(1), RXRA(1), RXRB(2), RXRG(1), SCD(1), SCP2(1), SLC27A1(3), SLC27A2(2), SLC27A4(1), SLC27A5(3), SLC27A6(3), SORBS1(2), UCP1(1) 14448619 95 33 94 18 28 25 18 9 13 2 0.00104 1.000 1.000 478 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ADH1A(3), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(4), ALDH1A3(2), ALDH3A1(1), ALDH3B1(2), ALDH3B2(1), AOC2(2), AOC3(3), AOX1(2), CARM1(2), DBH(1), DCT(2), DDC(1), ESCO1(3), GOT1(2), HEMK1(1), HGD(2), HPD(3), LCMT1(1), LCMT2(1), METTL2B(2), METTL6(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(2), SH3GLB1(1), TAT(1), TH(1), TPO(7), TYR(4), TYRP1(1) 13161772 74 20 74 23 26 15 16 9 7 1 0.171 1.000 1.000 479 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AADAT(2), AANAT(1), ACAT1(2), ACAT2(1), AFMID(2), ALDH1A3(2), ALDH3A1(1), ALDH3A2(1), AOC2(2), AOC3(3), AOX1(2), ASMT(1), CARM1(2), CAT(1), CYP1A1(2), CYP1A2(4), CYP1B1(1), DDC(1), EHHADH(1), GCDH(2), HAAO(1), HADH(1), HADHA(1), HEMK1(1), HSD17B4(3), INMT(1), KMO(2), KYNU(1), LCMT1(1), LCMT2(1), LNX1(1), METTL2B(2), METTL6(1), NFX1(1), OGDH(5), OGDHL(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(2), TDO2(1), TPH1(2), TPH2(2), WARS(2) 13398768 73 22 73 19 22 12 20 8 11 0 0.133 1.000 1.000 480 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 AKT1(1), APC(7), ASAH1(1), CAMP(2), DAG1(1), DLG4(3), EPHB2(4), GNAI1(1), GNAQ(1), ITPR1(10), ITPR2(4), ITPR3(8), KCNJ5(1), RYR1(23) 10259028 67 25 67 17 30 7 14 8 8 0 0.0545 1.000 1.000 481 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(1), ANKRD1(1), ATF3(1), DUSP14(1), IFRD1(3), JUND(1), MYOG(2), NR4A3(1), WDR1(2) 2439293 13 2 13 5 5 2 0 5 1 0 0.515 1.000 1.000 482 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA1(1), ACAD9(2), ADH1A(3), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(4), ALDH1A3(2), ALDH3A1(1), ALDH3A2(1), BAAT(1), CEL(1), CYP27A1(2), CYP7A1(2), HADHB(2), HSD3B7(3), LIPA(1), RDH11(2), SLC27A5(3), SOAT1(1) 7057317 41 11 41 15 13 9 9 5 5 0 0.454 1.000 1.000 483 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 247 ACVR1B(2), ACVR1C(1), AKT1(1), AKT2(2), AKT3(2), ARRB1(1), ARRB2(2), BDNF(1), BRAF(3), CACNA1A(8), CACNA1B(13), CACNA1C(8), CACNA1D(10), CACNA1E(9), CACNA1F(4), CACNA1G(9), CACNA1H(5), CACNA1I(9), CACNA1S(5), CACNA2D3(2), CACNA2D4(1), CACNB1(1), CACNB2(4), CACNG1(2), CACNG2(3), CACNG3(2), CACNG4(1), CACNG5(2), CASP3(2), CD14(1), CDC25B(1), CDC42(1), CHUK(1), CRK(1), CRKL(1), DAXX(3), DUSP10(2), DUSP14(1), DUSP16(2), DUSP6(2), DUSP7(1), DUSP9(1), EGF(5), EGFR(2), ELK1(2), ELK4(1), FASLG(1), FGF10(1), FGF12(1), FGF13(2), FGF14(2), FGF18(1), FGF23(1), FGF6(1), FGF7(1), FGF8(1), FGFR1(1), FGFR2(1), FGFR3(3), FGFR4(3), FLNA(10), FLNB(4), FLNC(10), HRAS(1), IKBKB(4), IL1B(1), IL1R2(1), JUND(1), KRAS(126), MAP2K3(1), MAP2K4(5), MAP2K6(3), MAP2K7(3), MAP3K1(3), MAP3K10(2), MAP3K12(2), MAP3K13(1), MAP3K2(2), MAP3K4(2), MAP3K5(1), MAP3K6(1), MAP3K7(2), MAP4K1(3), MAP4K2(3), MAP4K3(4), MAP4K4(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK7(4), MAPK8(2), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(4), MAPK9(1), MAPKAPK3(1), MAPKAPK5(1), MAPT(3), MAX(1), MEF2C(3), MKNK2(1), MOS(3), NF1(3), NFATC2(3), NFATC4(5), NFKB2(1), NLK(2), NR4A1(3), NTF3(4), NTRK1(2), NTRK2(3), PAK2(2), PDGFRA(3), PDGFRB(3), PLA2G1B(1), PLA2G3(1), PLA2G6(4), PPM1B(2), PPP3CA(2), PPP3CC(1), PPP3R1(1), PRKACB(1), PRKACG(3), PRKCG(2), PTPN5(1), RAC2(1), RAP1B(3), RAPGEF2(6), RASA1(2), RASA2(2), RASGRF1(1), RASGRF2(2), RASGRP1(2), RASGRP2(1), RASGRP3(2), RPS6KA2(2), RPS6KA3(1), RPS6KA4(2), RPS6KA5(2), RPS6KA6(4), RRAS(2), SOS1(2), SOS2(1), SRF(1), STK3(1), STK4(1), STMN1(1), TAOK1(4), TAOK2(4), TGFB1(1), TGFBR1(8), TGFBR2(10), TNFRSF1A(2), TP53(100), TRAF2(1), TRAF6(1), ZAK(2) 65118457 618 138 466 108 158 134 140 82 101 3 1.11e-15 1.000 1.000 484 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 35 ACTA1(3), CRK(1), CRKL(1), DOCK1(4), ELK1(2), HGF(1), HRAS(1), ITGA1(7), MAP4K1(3), MAPK8(2), MET(4), PIK3CA(4), PIK3R1(1), PTK2(3), PXN(1), RAP1B(3), RASA1(2), SOS1(2), SRC(2), STAT3(2) 9940539 49 18 49 16 10 16 4 9 10 0 0.398 1.000 1.000 485 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 AK3(1), CAD(6), CTPS2(1), DCK(1), DPYD(4), DPYS(3), DTYMK(1), DUT(1), ITPA(1), NME1(1), NT5E(1), NT5M(1), NUDT2(1), POLB(1), POLD1(2), POLD2(1), POLE(8), POLG(4), POLL(2), POLQ(3), POLR1B(3), POLR2A(5), POLR2B(4), POLR2E(1), POLR2G(1), POLRMT(2), RRM1(1), TYMS(1), UMPS(2), UPB1(2) 12824445 66 21 65 20 21 16 12 9 8 0 0.139 1.000 1.000 486 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(2), JAK1(1), PTPRU(6), REG1A(1), STAT1(3), STAT2(1), TYK2(2) 2763223 16 7 15 8 9 0 4 2 1 0 0.810 1.000 1.000 487 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 AKT1(1), ANGPTL2(1), DAG1(1), DGKA(1), ITPKB(3), ITPR1(10), ITPR2(4), ITPR3(8), NR1I3(1), PDE3A(8), PDE3B(2), PIK3CA(4), PIK3CD(2), PIK3R1(1), RIPK3(2), SGCB(1) 10895335 50 17 50 15 16 7 12 5 10 0 0.320 1.000 1.000 488 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(3), CSK(1), DAG1(1), DTYMK(1), EPHB2(4), FBXW7(5), GRAP2(2), ITK(1), ITPKB(3), LCK(1), LCP2(3), NCK1(4), NFAT5(4), NFKB2(1), NFKBIA(1), NFKBIB(1), NFKBIE(1), PAK2(2), PAK4(1), PAK6(1), PAK7(2), PLCG1(1), PTPRC(2), RASGRP1(2), RASGRP2(1), RASGRP3(2), SOS1(2), SOS2(1), VAV1(4), ZAP70(6) 12547437 64 20 62 19 19 15 8 8 12 2 0.306 1.000 1.000 489 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT1(1), AKT2(2), AKT3(2), BAD(1), BCR(2), BLNK(1), BTK(1), CD19(1), CD22(2), CD81(2), CR2(5), CSK(1), DAG1(1), FLOT2(1), GSK3A(1), GSK3B(2), INPP5D(1), ITPR1(10), ITPR2(4), ITPR3(8), MAP4K1(3), NFATC1(4), NFATC2(3), PDK1(1), PIK3CA(4), PIK3CD(2), PIK3R1(1), PLCG2(7), PPP3CA(2), PPP3CC(1), PTPRC(2), SHC1(1), SOS1(2), SOS2(1), SYK(2), VAV1(4) 16461341 89 26 89 20 29 19 12 15 13 1 0.00878 1.000 1.000 490 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 LDLR(1), MBTPS1(2), SCAP(3), SREBF2(2) 2756387 8 5 8 8 3 2 0 2 1 0 0.965 1.000 1.000 491 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 AANAT(1), ACAT1(2), ACAT2(1), ALDH1A1(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(1), AOC2(2), AOC3(3), AOX1(2), ASMT(1), CAT(1), CYP19A1(3), CYP1A1(2), CYP1A2(4), CYP2A13(2), CYP2A6(2), CYP2A7(2), CYP2B6(1), CYP2C18(3), CYP2C9(2), CYP2D6(2), CYP2E1(1), CYP2F1(2), CYP2J2(4), CYP3A5(1), CYP3A7(2), CYP4B1(1), DDC(1), EHHADH(1), GCDH(2), HAAO(1), HADHA(1), KMO(2), KYNU(1), TDO2(1), TPH1(2), WARS(2) 12144950 66 25 65 21 22 8 19 9 8 0 0.331 1.000 1.000 492 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(1), B4GALT2(1), G6PC2(1), GAA(2), GANC(1), GCK(1), GLB1(2), HK1(4), HK2(6), HK3(4), HSD3B7(3), LCT(5), MGAM(1), PFKL(2), PFKM(3), PGM1(1), RDH11(2), UGP2(3) 8609684 43 19 43 15 18 6 6 4 8 1 0.445 1.000 1.000 493 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(7), ATP6AP1(1), ATP6V0A1(3), ATP6V0A4(4), ATP6V0C(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1F(1), ATP6V1H(1), ATP7A(4), ATP7B(1), COX4I1(1), COX6A1(1), COX7C(1), NDUFA1(1), NDUFA10(2), NDUFA11(1), NDUFA8(1), NDUFS1(1), NDUFV1(1), NDUFV2(3), SDHA(3), SHMT1(1), UQCRB(1), UQCRFS1(1) 8449224 45 18 44 15 10 10 10 10 4 1 0.434 1.000 1.000 494 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BLNK(1), BTK(1), ELK1(2), HRAS(1), MAP3K1(3), MAPK8(2), NFATC1(4), NFATC2(3), NFATC3(2), NFATC4(5), PLCG1(1), PPP3CA(2), PPP3CC(1), SHC1(1), SOS1(2), SYK(2), SYT1(2), VAV1(4) 8466405 39 9 39 14 10 11 3 7 6 2 0.486 1.000 1.000 495 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 27 AKT1(1), AKT2(2), AKT3(2), BAD(1), GSK3A(1), GSK3B(2), IL4R(3), IRS1(4), IRS2(4), JAK1(1), JAK3(3), MAP4K1(3), PDK1(1), PIK3CA(4), PIK3CD(2), PIK3R1(1), SHC1(1), SOS1(2), SOS2(1), STAT6(5) 8251540 44 19 44 15 14 12 4 9 5 0 0.337 1.000 1.000 496 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 ASH1L(9), ASH2L(2), CARM1(2), CTCFL(1), DOT1L(1), EED(3), EHMT1(3), EHMT2(3), EZH1(2), EZH2(3), FBXO11(2), HCFC1(2), HSF4(1), KDM6A(6), MEN1(4), NSD1(6), OGT(4), PAXIP1(1), PPP1CA(1), PRDM2(6), PRDM9(4), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(2), RBBP5(1), SATB1(4), SETD1A(3), SETD2(5), SETD8(1), SETDB1(3), SETMAR(2), SMYD3(1), STK38(1), SUV39H2(3), SUV420H1(4), SUV420H2(2), SUZ12(4), WHSC1(1), WHSC1L1(2) 26751545 109 39 105 27 20 18 18 20 30 3 0.302 1.000 1.000 497 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 AICDA(1), AK3(1), CAD(6), CTPS2(1), DCK(1), DPYD(4), DPYS(3), DTYMK(1), DUT(1), ENTPD4(4), ENTPD5(1), ENTPD6(3), ENTPD8(2), ITPA(1), NME1(1), NME4(1), NME7(1), NT5C1B(2), NT5C2(1), NT5E(1), NT5M(1), NUDT2(1), PNPT1(2), POLA1(1), POLA2(1), POLD1(2), POLD2(1), POLE(8), POLE2(5), POLR1A(3), POLR1B(3), POLR2A(5), POLR2B(4), POLR2E(1), POLR2G(1), POLR3A(1), POLR3B(3), POLR3G(1), PRIM1(1), RRM1(1), RRM2B(1), TXNRD2(1), TYMS(1), UMPS(2), UPB1(2), UPP2(1) 18038719 91 30 88 28 24 17 19 18 13 0 0.263 1.000 1.000 498 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 83 ANPEP(3), CD14(1), CD19(1), CD1A(2), CD1B(4), CD1C(1), CD1D(3), CD1E(1), CD2(3), CD22(2), CD33(3), CD34(1), CD38(2), CD3E(1), CD4(2), CD44(4), CD5(1), CD55(1), CD59(1), CD8B(2), CR1(4), CR2(5), CSF1(2), CSF1R(1), CSF2RA(1), CSF3R(3), DNTT(4), EPO(2), EPOR(2), FCGR1A(1), FLT3(3), FLT3LG(1), GP5(2), GP9(2), HLA-DRB5(1), IL1B(1), IL1R2(1), IL3RA(2), IL4R(3), IL6(1), IL6R(1), IL7(1), IL7R(1), IL9R(1), ITGA1(7), ITGA2(2), ITGA3(1), ITGA4(1), ITGA5(1), ITGA6(4), ITGAM(4), ITGB3(1), KIT(4), MME(2), MS4A1(4), THPO(1), TPO(7) 18078651 124 43 123 34 29 22 25 26 22 0 0.0733 1.000 1.000 499 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(7), ATP4A(6), ATP5A1(2), ATP5B(3), ATP5C1(1), ATP5F1(1), ATP5G3(3), ATP5J2(1), ATP6AP1(1), ATP6V0A1(3), ATP6V0A2(1), ATP6V0A4(4), ATP6V0C(1), ATP6V0D2(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1F(1), ATP6V1H(1), COX15(1), COX4I1(1), COX4I2(2), COX6A1(1), COX7B2(2), COX7C(1), COX8C(1), NDUFA1(1), NDUFA10(2), NDUFA11(1), NDUFA4L2(1), NDUFA6(1), NDUFA7(1), NDUFA8(1), NDUFA9(1), NDUFB8(1), NDUFB9(1), NDUFS1(1), NDUFS6(1), NDUFS7(1), NDUFV1(1), NDUFV2(3), SDHA(3), TCIRG1(1), UQCRB(1), UQCRC2(1), UQCRFS1(1) 12417234 74 26 73 25 19 17 13 13 11 1 0.408 1.000 1.000 500 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 251 ACVR1B(2), ACVR2A(4), AMH(1), AMHR2(3), BMP2(1), BMP7(1), BMPR1A(3), BMPR2(3), CCL1(2), CCL16(1), CCL21(1), CCL24(2), CCL26(1), CCL27(1), CCL3(1), CCL7(1), CCL8(1), CCR1(1), CCR2(1), CCR4(3), CCR7(1), CCR9(1), CD40(1), CRLF2(1), CSF1(2), CSF1R(1), CSF2RA(1), CSF2RB(2), CSF3R(3), CX3CL1(3), CX3CR1(1), CXCR4(3), EDA(2), EDA2R(1), EDAR(1), EGF(5), EGFR(2), EPO(2), EPOR(2), FASLG(1), FLT1(3), FLT3(3), FLT3LG(1), FLT4(9), GDF5(1), GHR(2), HGF(1), IFNA10(1), IFNA16(1), IFNA7(2), IFNAR1(2), IFNAR2(2), IFNGR1(2), IFNK(1), IL10RA(2), IL10RB(1), IL12B(1), IL15RA(1), IL17RA(2), IL18RAP(2), IL1B(1), IL1R2(1), IL1RAP(2), IL20RA(2), IL21(2), IL21R(1), IL22(1), IL22RA1(1), IL23R(1), IL26(1), IL2RB(2), IL3RA(2), IL4R(3), IL6(1), IL6R(1), IL6ST(3), IL7(1), IL7R(1), IL9(1), IL9R(1), INHBA(2), INHBB(2), INHBC(1), KDR(1), KIT(4), LEPR(7), LIF(1), LIFR(5), LTBR(1), MET(4), NGFR(1), OSMR(3), PDGFC(2), PDGFRA(3), PDGFRB(3), PLEKHO2(1), PRL(6), PRLR(2), RELT(1), TGFB1(1), TGFBR1(8), TGFBR2(10), TNFRSF10A(2), TNFRSF10B(2), TNFRSF11A(2), TNFRSF11B(1), TNFRSF12A(1), TNFRSF13B(1), TNFRSF13C(1), TNFRSF19(3), TNFRSF1A(2), TNFRSF1B(1), TNFRSF21(2), TNFRSF8(1), TNFRSF9(1), TNFSF12(2), TNFSF13(3), TNFSF14(1), TNFSF18(1), TNFSF8(3), TPO(7), TSLP(1), XCR1(3) 39512702 249 70 249 64 72 54 42 40 40 1 0.000844 1.000 1.000 501 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 78 ABL1(5), ACTN1(1), AKT1(1), AKT2(2), AKT3(2), ANGPTL2(1), ARHGEF6(2), ARHGEF7(2), BCAR1(2), BRAF(3), CDC42(1), CDKN2A(31), CRK(1), CSE1L(3), DOCK1(4), EPHB2(4), GRB7(2), ILK(1), ITGA1(7), ITGA2(2), ITGA3(1), ITGA4(1), ITGA5(1), ITGA6(4), ITGA7(6), ITGA8(2), ITGB3BP(1), MAP2K4(5), MAP2K7(3), MAPK8(2), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(4), MAPK9(1), MYLK(13), MYLK2(4), PAK2(2), PAK4(1), PAK6(1), PAK7(2), PIK3CA(4), PIK3CB(1), PKLR(2), PLCG1(1), PLCG2(7), PTK2(3), ROCK1(5), ROCK2(2), SHC1(1), SOS1(2), SOS2(1), SRC(2), TERF2IP(1), TLN1(12), TLN2(5), ZYX(1) 27443444 183 65 170 46 44 36 26 30 45 2 0.0165 1.000 1.000 502 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 64 ACHE(3), AGPAT1(1), AGPAT3(2), AGPAT4(3), CDIPT(3), CHAT(4), DGKA(1), DGKB(2), DGKD(2), DGKG(1), DGKH(3), DGKI(4), DGKQ(3), DGKZ(3), ESCO1(3), ETNK2(2), GPAM(4), GPD1(1), GPD2(1), PCYT1A(2), PCYT1B(1), PHOSPHO1(1), PLA2G1B(1), PLA2G3(1), PLA2G6(4), PLD2(4), PPAP2B(2), PPAP2C(1), PTDSS1(2), PTDSS2(1), SH3GLB1(1) 14718836 67 22 66 23 21 10 14 12 10 0 0.320 1.000 1.000 503 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADCY1(4), ADCY2(2), ADCY3(6), ADCY4(1), ADCY5(5), ADCY6(3), ADCY7(2), ADCY8(4), ADSL(2), ADSS(1), AK2(1), ALLC(2), AMPD1(3), AMPD2(2), AMPD3(3), APRT(1), ATIC(2), ATP1B1(1), ATP5A1(2), ATP5B(3), ATP5C1(1), ATP5F1(1), ATP5G3(3), ATP5J2(1), DCK(1), DGUOK(1), ENPP3(3), ENTPD2(4), FHIT(1), GART(1), GUCY1A3(2), GUCY1B3(2), GUCY2C(4), GUCY2D(1), GUCY2F(3), IMPDH1(2), ITPA(1), NME1(1), NPR1(1), NPR2(2), NT5E(1), NT5M(1), NUDT2(1), PAICS(2), PAPSS1(2), PAPSS2(6), PDE4A(1), PDE4C(2), PDE4D(2), PDE5A(3), PDE6B(3), PDE6C(1), PDE7B(1), PDE8A(2), PDE9A(1), PFAS(7), PKLR(2), POLB(1), POLD1(2), POLD2(1), POLE(8), POLG(4), POLL(2), POLQ(3), POLR1B(3), POLR2A(5), POLR2B(4), POLR2E(1), POLR2G(1), POLRMT(2), PPAT(2), PRPS1(1), PRPS1L1(3), RRM1(1) 28644458 168 53 166 41 61 34 27 18 26 2 0.00411 1.000 1.000 504 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 63 AKT1(1), AKT2(2), AKT3(2), BAD(1), CDC42(1), CDKN2A(31), CREB1(2), CREB5(1), ERBB4(6), F2RL2(2), GSK3A(1), GSK3B(2), IFI27(1), INPPL1(2), IRS1(4), IRS2(4), IRS4(16), MET(4), PAK2(2), PAK4(1), PAK6(1), PAK7(2), PARD3(4), PARD6A(1), PDK1(1), PIK3CA(4), PIK3CD(2), PREX1(8), PTK2(3), RPS6KA2(2), RPS6KA3(1), SHC1(1), SOS1(2), SOS2(1), TSC1(2), TSC2(6), YWHAE(2), YWHAG(1), YWHAH(1) 17241172 131 68 108 36 21 20 16 20 53 1 0.304 1.000 1.000 505 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(6), ABCA10(3), ABCA12(14), ABCA13(12), ABCA2(5), ABCA3(6), ABCA4(6), ABCA5(4), ABCA6(5), ABCA7(7), ABCA8(6), ABCA9(9), ABCB1(5), ABCB10(2), ABCB11(2), ABCB4(1), ABCB5(6), ABCB6(4), ABCB8(1), ABCC1(1), ABCC10(4), ABCC11(3), ABCC12(5), ABCC2(3), ABCC3(2), ABCC4(4), ABCC5(2), ABCC6(5), ABCC8(1), ABCC9(3), ABCD1(1), ABCD2(2), ABCD3(1), ABCG1(3), ABCG2(1), ABCG4(4), ABCG5(3), ABCG8(2), CFTR(7), TAP1(4), TAP2(1) 26349773 166 52 160 46 46 35 24 34 24 3 0.0216 1.000 1.000 506 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 127 ABL1(5), ABLIM1(5), ABLIM2(1), ABLIM3(2), ARHGEF12(5), CDC42(1), CXCR4(3), DCC(5), DPYSL2(1), DPYSL5(3), EFNA1(1), EFNB2(1), EPHA1(4), EPHA2(5), EPHA3(1), EPHA4(3), EPHA5(6), EPHA6(3), EPHA7(3), EPHA8(7), EPHB1(2), EPHB2(4), EPHB3(3), EPHB4(5), EPHB6(2), GNAI1(1), GNAI2(1), GSK3B(2), HRAS(1), KRAS(126), L1CAM(5), LIMK2(2), LRRC4C(4), MET(4), NCK1(4), NCK2(2), NFAT5(4), NFATC1(4), NFATC2(3), NFATC3(2), NFATC4(5), NRP1(1), NTN4(1), NTNG1(2), PAK2(2), PAK4(1), PAK6(1), PAK7(2), PLXNA1(5), PLXNA2(9), PLXNA3(7), PLXNB1(4), PLXNB2(5), PLXNB3(6), PLXNC1(2), PPP3CA(2), PPP3CC(1), PPP3R1(1), PTK2(3), RAC2(1), RASA1(2), RGS3(1), RHOA(1), RHOD(1), RND1(2), ROBO1(7), ROBO2(4), ROBO3(4), ROCK1(5), ROCK2(2), SEMA3A(2), SEMA3C(1), SEMA3D(5), SEMA3E(2), SEMA3F(2), SEMA3G(2), SEMA4A(1), SEMA4C(4), SEMA4F(2), SEMA4G(3), SEMA5A(5), SEMA5B(4), SEMA6A(2), SEMA6C(2), SEMA6D(1), SEMA7A(1), SLIT1(6), SLIT2(7), SLIT3(4), SRGAP1(5), SRGAP2(1), SRGAP3(4), UNC5A(2), UNC5B(1), UNC5C(4), UNC5D(4) 44321722 413 136 289 108 99 115 109 52 36 2 1.91e-05 1.000 1.000 507 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 203 ABI2(2), ACTN1(1), ACTN2(4), APC(7), APC2(2), ARAF(2), ARHGEF1(2), ARHGEF12(5), ARHGEF6(2), ARHGEF7(2), ARPC1A(1), ARPC2(1), ARPC5(1), ARPC5L(1), BAIAP2(3), BCAR1(2), BDKRB2(1), BRAF(3), CD14(1), CDC42(1), CHRM1(1), CHRM2(3), CHRM3(1), CHRM5(3), CRK(1), CRKL(1), CSK(1), CYFIP2(2), DIAPH1(7), DIAPH2(1), DIAPH3(2), DOCK1(4), EGF(5), EGFR(2), FGD1(1), FGF10(1), FGF12(1), FGF13(2), FGF14(2), FGF18(1), FGF23(1), FGF6(1), FGF7(1), FGF8(1), FGFR1(1), FGFR2(1), FGFR3(3), FGFR4(3), FN1(7), GIT1(3), GSN(4), HRAS(1), IQGAP1(2), IQGAP2(1), IQGAP3(3), ITGA1(7), ITGA2(2), ITGA3(1), ITGA4(1), ITGA5(1), ITGA6(4), ITGA7(6), ITGA8(2), ITGAD(2), ITGAE(3), ITGAL(2), ITGAM(4), ITGAV(3), ITGAX(3), ITGB2(1), ITGB3(1), ITGB4(7), ITGB5(3), ITGB6(3), ITGB8(4), KRAS(126), LIMK2(2), MOS(3), MYH10(4), MYH14(4), MYH9(4), MYL9(1), MYLK(13), MYLK2(4), NCKAP1(5), NCKAP1L(5), PAK2(2), PAK4(1), PAK6(1), PAK7(2), PDGFRA(3), PDGFRB(3), PIK3CA(4), PIK3CB(1), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PIP4K2A(2), PIP4K2C(1), PIP5K1B(2), PIP5K1C(1), PPP1CA(1), PTK2(3), PXN(1), RAC2(1), RDX(4), RHOA(1), ROCK1(5), ROCK2(2), RRAS(2), SCIN(1), SOS1(2), SOS2(1), SSH1(4), TIAM1(8), TIAM2(5), VAV1(4), VCL(1), WASF1(1), WASF2(1), WASL(2) 62145660 435 132 309 114 102 117 124 49 41 2 3.83e-05 1.000 1.000 508 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 192 ACTB(1), ACTN1(1), ACTN2(4), AKT1(1), AKT2(2), AKT3(2), ARHGAP5(5), BAD(1), BCAR1(2), BIRC2(2), BRAF(3), CCND2(3), CCND3(1), CDC42(1), CHAD(1), COL11A1(7), COL11A2(2), COL1A1(3), COL1A2(7), COL2A1(3), COL3A1(6), COL4A1(4), COL4A2(6), COL4A4(4), COL4A6(4), COL5A1(15), COL5A2(7), COL5A3(5), COL6A1(1), COL6A2(6), COL6A3(9), COL6A6(6), COMP(2), CRK(1), CRKL(1), CTNNB1(7), DIAPH1(7), DOCK1(4), EGF(5), EGFR(2), ELK1(2), ERBB2(6), FARP2(3), FLNA(10), FLNB(4), FLNC(10), FLT1(3), FN1(7), GSK3B(2), HGF(1), HRAS(1), IBSP(3), IGF1R(6), ILK(1), ITGA1(7), ITGA2(2), ITGA3(1), ITGA4(1), ITGA5(1), ITGA6(4), ITGA7(6), ITGA8(2), ITGAV(3), ITGB3(1), ITGB4(7), ITGB5(3), ITGB6(3), ITGB8(4), KDR(1), LAMA1(10), LAMA2(9), LAMA3(5), LAMA4(6), LAMA5(7), LAMB1(4), LAMB2(6), LAMB3(3), LAMB4(4), LAMC1(3), LAMC2(2), LAMC3(2), MAPK8(2), MAPK9(1), MET(4), MYL9(1), MYLK(13), MYLK2(4), PAK2(2), PAK4(1), PAK6(1), PAK7(2), PARVB(2), PARVG(1), PDGFC(2), PDGFRA(3), PDGFRB(3), PIK3CA(4), PIK3CB(1), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PIP5K1C(1), PPP1CA(1), PRKCG(2), PTK2(3), PXN(1), RAC2(1), RAP1B(3), RELN(13), RHOA(1), ROCK1(5), ROCK2(2), SHC1(1), SHC2(2), SHC4(1), SOS1(2), SOS2(1), SRC(2), THBS1(3), THBS2(4), THBS4(2), TLN1(12), TLN2(5), TNC(13), TNN(4), TNR(10), TNXB(9), VAV1(4), VCL(1), VTN(2), VWF(4), ZYX(1) 82855584 495 107 491 152 147 105 90 78 69 6 0.00688 1.000 1.000 509 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 169 ADCY1(4), ADCY2(2), ADCY3(6), ADCY4(1), ADCY7(2), ADCY8(4), ADCY9(4), ADORA2A(1), ADRA1A(3), ADRA1D(1), ADRB2(1), ATP2A1(5), ATP2A2(2), ATP2B1(7), ATP2B2(4), ATP2B3(1), ATP2B4(2), AVPR1A(1), AVPR1B(1), BDKRB2(1), CACNA1A(8), CACNA1B(13), CACNA1C(8), CACNA1D(10), CACNA1E(9), CACNA1F(4), CACNA1G(9), CACNA1H(5), CACNA1I(9), CACNA1S(5), CALML3(1), CAMK2D(1), CAMK4(1), CCKAR(4), CCKBR(3), CD38(2), CHRM1(1), CHRM2(3), CHRM3(1), CHRM5(3), CHRNA7(1), CYSLTR2(1), DRD1(5), EDNRB(2), EGFR(2), ERBB2(6), ERBB3(4), ERBB4(6), GNA11(2), GNA14(1), GNA15(3), GNAL(2), GNAQ(1), GNAS(12), GRIN1(1), GRIN2A(6), GRIN2C(4), GRIN2D(5), GRM1(9), GRM5(7), GRPR(1), HRH2(1), HTR2A(3), HTR2B(1), HTR2C(5), HTR4(1), HTR5A(4), HTR7(1), ITPKB(3), ITPR1(10), ITPR2(4), ITPR3(8), LHCGR(2), LTB4R2(1), MYLK(13), MYLK2(4), NOS1(7), NOS3(8), OXTR(2), P2RX2(1), P2RX5(1), P2RX7(1), PDE1B(1), PDE1C(1), PDGFRA(3), PDGFRB(3), PHKA2(5), PHKB(3), PHKG1(2), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), PLCD1(1), PLCD3(1), PLCD4(3), PLCE1(5), PLCG1(1), PLCG2(7), PPP3CA(2), PPP3CC(1), PPP3R1(1), PRKACB(1), PRKACG(3), PRKCG(2), PTGER3(1), PTGFR(2), RYR1(23), RYR2(15), RYR3(22), SLC25A4(1), SLC25A6(2), SLC8A1(2), SLC8A2(3), SLC8A3(5), SPHK1(1), TACR1(3), TACR2(1), TACR3(2), TBXA2R(1), TNNC1(2), TNNC2(1), TRHR(2), TRPC1(2), VDAC1(2), VDAC2(1) 61166999 466 101 454 135 184 65 97 67 47 6 0.000123 1.000 1.000 510 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 137 ACTB(1), CHAD(1), COL11A1(7), COL11A2(2), COL17A1(3), COL1A1(3), COL1A2(7), COL2A1(3), COL3A1(6), COL4A1(4), COL4A2(6), COL4A4(4), COL4A6(4), COL5A1(15), COL5A2(7), COL5A3(5), COL6A1(1), COL6A2(6), COL6A3(9), COL6A6(6), COMP(2), DES(1), DSC1(4), DSC2(4), DSC3(4), DSG1(2), DSG2(3), DSG3(1), DSG4(4), FN1(7), GJA1(1), GJA3(1), GJA4(2), GJA5(1), GJA8(2), GJB1(1), GJB4(1), GJB6(2), GJB7(1), GJC1(2), GJC2(2), GJC3(2), GJD4(2), IBSP(3), INA(2), ITGA6(4), ITGB4(7), KRT1(2), KRT12(2), KRT13(2), KRT14(1), KRT15(2), KRT16(1), KRT17(3), KRT19(1), KRT2(7), KRT20(2), KRT24(3), KRT27(1), KRT28(2), KRT3(2), KRT31(2), KRT33A(2), KRT33B(1), KRT34(3), KRT37(1), KRT38(2), KRT39(1), KRT4(2), KRT40(1), KRT5(1), KRT6A(3), KRT6B(1), KRT7(2), KRT72(1), KRT73(1), KRT74(3), KRT75(1), KRT76(5), KRT77(1), KRT78(2), KRT79(2), KRT82(2), KRT83(3), KRT85(1), KRT86(2), LAMA1(10), LAMA2(9), LAMA3(5), LAMA4(6), LAMA5(7), LAMB1(4), LAMB2(6), LAMB3(3), LAMB4(4), LAMC1(3), LAMC2(2), LAMC3(2), LMNB2(1), NES(4), PRPH(1), RELN(13), THBS1(3), THBS2(4), THBS4(2), TNC(13), TNN(4), TNR(10), TNXB(9), VTN(2), VWF(4) 55629037 376 95 370 123 121 70 77 54 51 3 0.0495 1.000 1.000 511 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 238 ADORA2A(1), ADORA3(6), ADRA1A(3), ADRA2A(1), ADRA2B(4), ADRA2C(2), ADRB2(1), AVPR1A(1), AVPR1B(1), AVPR2(2), BDKRB2(1), C3AR1(3), C5AR1(1), CALCR(1), CCKAR(4), CCKBR(3), CGA(1), CHRM1(1), CHRM2(3), CHRM3(1), CHRM5(3), CRHR1(1), CRHR2(1), CTSG(2), CYSLTR2(1), DRD1(5), DRD5(2), EDNRB(2), F2RL1(2), F2RL2(2), F2RL3(1), FPR1(2), FSHB(1), FSHR(3), GABBR1(2), GABBR2(2), GABRA2(1), GABRA4(5), GABRA5(5), GABRA6(2), GABRB1(3), GABRB2(1), GABRB3(4), GABRD(2), GABRE(1), GABRG1(1), GABRG2(1), GABRG3(2), GABRP(1), GABRQ(2), GABRR2(1), GALR1(2), GALR2(1), GHR(2), GHRHR(1), GIPR(1), GLP2R(3), GLRA1(3), GLRA2(3), GLRB(1), GNRHR(1), GPR156(2), GPR35(1), GPR50(1), GPR83(1), GRIA1(1), GRIA3(2), GRIA4(2), GRID1(7), GRID2(8), GRIK1(1), GRIK2(9), GRIK3(3), GRIK4(2), GRIK5(2), GRIN1(1), GRIN2A(6), GRIN2B(7), GRIN2C(4), GRIN2D(5), GRIN3A(3), GRIN3B(3), GRM1(9), GRM2(4), GRM3(2), GRM4(3), GRM5(7), GRM6(3), GRM7(4), GRM8(4), GRPR(1), HCRTR1(2), HCRTR2(2), HRH2(1), HTR1A(3), HTR1D(2), HTR1F(1), HTR2A(3), HTR2B(1), HTR2C(5), HTR4(1), HTR5A(4), HTR7(1), LEPR(7), LHCGR(2), LTB4R(3), LTB4R2(1), MC2R(2), MC3R(4), MC5R(3), MCHR1(2), MCHR2(1), MLNR(1), MTNR1A(2), MTNR1B(2), NMUR1(1), NMUR2(3), NPBWR1(1), NPFFR1(1), NPFFR2(1), NPY1R(3), NPY2R(2), NPY5R(1), NR3C1(2), OPRD1(2), OPRK1(2), OPRL1(2), OPRM1(1), OXTR(2), P2RX2(1), P2RX5(1), P2RX7(1), P2RY1(6), P2RY13(3), P2RY14(2), P2RY2(1), P2RY4(1), P2RY6(1), P2RY8(3), PARD3(4), PRL(6), PRLR(2), PRSS1(3), PRSS3(3), PTGDR(2), PTGER3(1), PTGFR(2), RXFP1(1), SSTR1(2), SSTR4(3), SSTR5(5), TAAR1(1), TAAR2(1), TAAR5(2), TAAR6(1), TAAR8(3), TACR1(3), TACR2(1), TACR3(2), TBXA2R(1), THRA(1), THRB(1), TRHR(2), TRPV1(3), TSHR(3), UTS2R(1), VIPR1(1), VIPR2(1) 49630855 393 89 384 128 143 66 80 59 42 3 0.00269 1.000 1.000 512 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(2), CD44(4), CHAD(1), COL11A1(7), COL11A2(2), COL1A1(3), COL1A2(7), COL2A1(3), COL3A1(6), COL4A1(4), COL4A2(6), COL4A4(4), COL4A6(4), COL5A1(15), COL5A2(7), COL5A3(5), COL6A1(1), COL6A2(6), COL6A3(9), COL6A6(6), DAG1(1), FN1(7), FNDC1(19), FNDC3A(3), FNDC5(1), GP5(2), GP6(1), GP9(2), HMMR(3), HSPG2(3), IBSP(3), ITGA1(7), ITGA2(2), ITGA3(1), ITGA4(1), ITGA5(1), ITGA6(4), ITGA7(6), ITGA8(2), ITGAV(3), ITGB3(1), ITGB4(7), ITGB5(3), ITGB6(3), ITGB8(4), LAMA1(10), LAMA2(9), LAMA3(5), LAMA4(6), LAMA5(7), LAMB1(4), LAMB2(6), LAMB3(3), LAMB4(4), LAMC1(3), LAMC2(2), LAMC3(2), RELN(13), SDC3(1), SDC4(2), SV2A(2), SV2C(1), THBS1(3), THBS2(4), THBS4(2), TNC(13), TNN(4), TNR(10), TNXB(9), VTN(2), VWF(4) 50244089 323 85 309 99 85 66 68 46 55 3 0.0717 1.000 1.000 513 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(4), ADCY2(2), ADCY3(6), ADCY4(1), ADCY5(5), ADCY6(3), ADCY7(2), ADCY8(4), ADCY9(4), ADRA1A(3), ADRA1D(1), ADRB2(1), ANXA6(3), ARRB1(1), ARRB2(2), ATP1A4(3), ATP1B1(1), ATP1B3(1), ATP2A2(2), ATP2B1(7), ATP2B2(4), ATP2B3(1), CACNA1A(8), CACNA1B(13), CACNA1C(8), CACNA1D(10), CACNA1E(9), CACNA1S(5), CACNB1(1), CAMK1(2), CAMK2D(1), CAMK4(1), CASQ1(1), CASQ2(8), CHRM1(1), CHRM2(3), CHRM3(1), CHRM5(3), GJA1(1), GJA4(2), GJA5(1), GJB1(1), GJB4(1), GJB6(2), GNA11(2), GNAI2(1), GNAO1(2), GNAQ(1), GNAZ(1), GNB1(3), GNB2(1), GNB3(2), GNB4(1), GNB5(1), GRK4(2), GRK5(1), GRK6(1), ITPR1(10), ITPR2(4), ITPR3(8), KCNB1(5), KCNJ5(1), MIB1(4), NME7(1), PLCB3(4), PRKACB(1), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PRKCD(4), PRKCE(1), PRKCG(2), PRKCH(1), PRKCQ(2), RGS1(1), RGS10(1), RGS16(1), RGS17(1), RGS2(1), RGS3(1), RGS7(2), RGS9(1), RYR1(23), RYR2(15), RYR3(22), SLC8A1(2), SLC8A3(5), USP5(2), YWHAH(1) 42257470 294 80 286 96 110 52 56 34 37 5 0.0217 1.000 1.000 514 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA1(3), ACTA2(2), ADCY1(4), ADCY2(2), ADCY3(6), ADCY4(1), ADCY5(5), ADCY6(3), ADCY7(2), ADCY8(4), ADCY9(4), ADM(1), ARRB1(1), ARRB2(2), ATF1(1), ATF3(1), ATF5(1), ATP2A2(2), CALCA(1), CAMK2D(1), CNN2(1), CORIN(2), CRHR1(1), DGKZ(3), ETS2(2), GABPA(2), GABPB2(1), GBA2(4), GJA1(1), GNAQ(1), GNB1(3), GNB2(1), GNB3(2), GNB4(1), GNB5(1), GRK4(2), GRK5(1), GRK6(1), GUCY1A3(2), IGFBP4(1), IL1B(1), IL6(1), ITPR1(10), ITPR2(4), ITPR3(8), MAFF(2), MIB1(4), MYLK2(4), NOS1(7), NOS3(8), OXTR(2), PDE4D(2), PLCB3(4), PLCD1(1), PLCG1(1), PLCG2(7), PRKACB(1), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PRKCD(4), PRKCE(1), PRKCH(1), PRKCQ(2), RGS1(1), RGS10(1), RGS16(1), RGS17(1), RGS2(1), RGS3(1), RGS7(2), RGS9(1), RYR1(23), RYR2(15), RYR3(22), SLC8A1(2), SP1(1), TNXB(9), USP5(2), YWHAH(1) 38938213 243 67 243 87 94 42 47 31 26 3 0.126 1.000 1.000 515 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 164 ADORA2A(1), ADORA3(6), ADRA1A(3), ADRA1D(1), ADRA2A(1), ADRA2C(2), ADRB2(1), AVPR1A(1), AVPR1B(1), AVPR2(2), BDKRB2(1), C3AR1(3), CCKAR(4), CCKBR(3), CCR1(1), CCR10(1), CCR2(1), CCR4(3), CCR7(1), CCR9(1), CCRL2(3), CHML(4), CHRM1(1), CHRM2(3), CHRM3(1), CHRM5(3), CMKLR1(1), CX3CR1(1), CXCR4(3), DRD1(5), DRD5(2), EDNRB(2), F2RL1(2), F2RL2(2), F2RL3(1), FPR1(2), FSHR(3), GALR1(2), GALR2(1), GPR173(1), GPR174(1), GPR3(1), GPR35(1), GPR4(2), GPR50(1), GPR6(12), GPR83(1), GPR87(1), GRPR(1), HCRTR1(2), HCRTR2(2), HRH2(1), HTR1A(3), HTR1D(2), HTR1F(1), HTR2A(3), HTR2B(1), HTR2C(5), HTR4(1), HTR5A(4), HTR7(1), LHCGR(2), LTB4R(3), MC3R(4), MC5R(3), MLNR(1), MTNR1A(2), MTNR1B(2), NMUR1(1), NMUR2(3), NPY1R(3), NPY2R(2), NPY5R(1), OPN1SW(1), OPN3(2), OPRD1(2), OPRK1(2), OPRL1(2), OPRM1(1), OR10A5(1), OR1C1(3), OR1F1(1), OR1Q1(1), OR8B8(1), OXTR(2), P2RY1(6), P2RY12(1), P2RY13(3), P2RY14(2), P2RY2(1), P2RY6(1), PTGDR(2), PTGFR(2), RGR(1), RRH(1), SSTR1(2), SSTR4(3), SUCNR1(1), TBXA2R(1), TRHR(2) 27201630 203 63 190 63 65 28 53 28 28 1 0.0346 1.000 1.000 516 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADCY1(4), ADCY2(2), ADCY3(6), ADCY4(1), ADCY5(5), ADCY6(3), ADCY7(2), ADCY8(4), ADCY9(4), ADSL(2), ADSS(1), ADSSL1(1), AK2(1), AK7(3), ALLC(2), AMPD1(3), AMPD2(2), AMPD3(3), APRT(1), ATIC(2), DCK(1), DGUOK(1), ENPP3(3), ENTPD2(4), ENTPD4(4), ENTPD5(1), ENTPD6(3), ENTPD8(2), FHIT(1), GART(1), GMPR(2), GUCY1A3(2), GUCY1B3(2), GUCY2C(4), GUCY2D(1), GUCY2F(3), IMPDH1(2), ITPA(1), NME1(1), NME4(1), NME7(1), NPR1(1), NPR2(2), NT5C1B(2), NT5C2(1), NT5E(1), NT5M(1), NUDT2(1), NUDT9(1), PAICS(2), PAPSS1(2), PAPSS2(6), PDE10A(8), PDE11A(1), PDE1C(1), PDE2A(1), PDE3B(2), PDE4A(1), PDE4C(2), PDE4D(2), PDE5A(3), PDE7B(1), PDE8A(2), PDE8B(3), PDE9A(1), PFAS(7), PKLR(2), PNPT1(2), POLA1(1), POLA2(1), POLD1(2), POLD2(1), POLE(8), POLE2(5), POLR1A(3), POLR1B(3), POLR2A(5), POLR2B(4), POLR2E(1), POLR2G(1), POLR3A(1), POLR3B(3), POLR3G(1), PPAT(2), PRIM1(1), PRPS1(1), PRPS1L1(3), RRM1(1), RRM2B(1), XDH(5) 36422480 206 62 201 58 71 36 32 35 30 2 0.0362 1.000 1.000 517 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 130 ALCAM(1), CADM1(4), CADM3(2), CD2(3), CD22(2), CD226(1), CD274(1), CD276(2), CD34(1), CD4(2), CD40(1), CD58(1), CD6(1), CD80(2), CD86(6), CD8B(2), CDH1(1), CDH15(4), CDH2(5), CDH4(5), CDH5(2), CLDN17(3), CLDN22(1), CLDN3(2), CLDN9(2), CNTN1(5), CNTN2(1), CNTNAP1(1), CNTNAP2(7), ESAM(1), F11R(1), GLG1(2), HLA-A(2), HLA-DMB(1), HLA-DPA1(1), HLA-DQA2(1), HLA-DRB5(1), HLA-F(1), HLA-G(2), ICAM1(2), ICAM3(1), ICOSLG(1), ITGA4(1), ITGA6(4), ITGA8(2), ITGAL(2), ITGAM(4), ITGAV(3), ITGB2(1), ITGB8(4), JAM2(2), L1CAM(5), NCAM1(2), NCAM2(6), NEGR1(3), NEO1(2), NFASC(4), NLGN1(6), NLGN2(2), NLGN3(4), NRCAM(1), NRXN1(3), NRXN2(4), NRXN3(4), PDCD1(1), PTPRC(2), PTPRF(4), PTPRM(6), PVRL1(2), PVRL2(1), PVRL3(1), SDC3(1), SDC4(2), SELE(2), SELL(1), SELP(2), SELPLG(1), SIGLEC1(12), VCAN(10) 32926568 205 59 200 79 67 34 37 29 36 2 0.377 1.000 1.000 518 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 151 AKT1(1), AKT2(2), AKT3(2), CBL(3), CBLB(2), CCND2(3), CCND3(1), CISH(1), CREBBP(3), CRLF2(1), CSF2RA(1), CSF2RB(2), CSF3R(3), EP300(6), EPO(2), EPOR(2), GHR(2), IFNA10(1), IFNA16(1), IFNA7(2), IFNAR1(2), IFNAR2(2), IFNGR1(2), IFNK(1), IL10RA(2), IL10RB(1), IL12B(1), IL13RA2(1), IL15RA(1), IL20RA(2), IL21(2), IL21R(1), IL22(1), IL22RA1(1), IL23R(1), IL26(1), IL2RB(2), IL3RA(2), IL4R(3), IL6(1), IL6R(1), IL6ST(3), IL7(1), IL7R(1), IL9(1), IL9R(1), IRF9(1), JAK1(1), JAK2(6), JAK3(3), LEPR(7), LIF(1), LIFR(5), OSMR(3), PIAS1(1), PIAS2(3), PIAS3(1), PIAS4(2), PIK3CA(4), PIK3CB(1), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PRL(6), PRLR(2), PTPN6(4), SOCS4(2), SOCS5(5), SOS1(2), SOS2(1), SPRED1(1), SPRED2(1), STAM(2), STAM2(1), STAT1(3), STAT2(1), STAT3(2), STAT4(1), STAT5A(1), STAT6(5), TPO(7), TSLP(1), TYK2(2) 32198529 180 56 179 63 55 30 31 35 28 1 0.390 1.000 1.000 519 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(3), ACTA2(2), ACTN2(4), DES(1), DMD(9), MYBPC1(3), MYBPC2(1), MYBPC3(3), MYH3(2), MYH6(6), MYH7(8), MYH8(4), MYL1(1), MYL3(3), MYL9(1), MYOM1(4), NEB(18), TMOD1(1), TNNC2(1), TNNI1(1), TNNI2(1), TNNI3(4), TNNT2(2), TNNT3(1), TPM1(1), TPM2(1), TPM3(1), TTN(99) 30526748 186 54 186 57 50 41 44 26 22 3 0.271 1.000 1.000 520 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(4), AMY2A(3), ASCC3(5), ATP13A2(1), DDX18(1), DDX23(1), DDX4(8), DDX41(2), DDX47(5), DDX50(3), DDX51(1), DDX52(1), DDX54(2), DDX55(1), DDX56(2), DHX58(4), ENPP3(3), EP400(2), ERCC2(2), ERCC3(3), G6PC2(1), GAA(2), GANC(1), GBA(3), GBE1(4), GCK(1), GPI(3), GUSB(1), GYS1(3), GYS2(2), HK1(4), HK2(6), HK3(4), IFIH1(5), MGAM(1), MOV10L1(5), NUDT8(1), PGM1(1), PYGL(2), PYGM(1), RAD54B(2), RAD54L(5), RUVBL2(3), SETX(3), SI(5), SKIV2L2(2), SMARCA2(3), SMARCA5(1), UGDH(2), UGP2(3), UGT1A1(1), UGT1A10(2), UGT1A4(2), UGT1A6(2), UGT1A7(1), UGT2A3(1), UGT2B10(4), UGT2B15(2), UGT2B17(1), UGT2B28(3), UGT2B4(1), UXS1(2) 27435584 156 53 152 54 42 32 24 24 32 2 0.614 1.000 1.000 521 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CLK2(1), CLK3(2), CLK4(2), COL2A1(3), CPSF1(3), CPSF2(4), CPSF4(1), CSTF1(1), CSTF2(1), CSTF2T(3), CSTF3(3), DDX20(1), DHX15(4), DHX16(4), DHX38(2), DHX8(3), DHX9(2), DICER1(9), LSM2(2), METTL3(2), NCBP2(2), NONO(1), NUDT21(1), NXF1(2), PABPN1(2), PAPOLA(2), PHF5A(1), POLR2A(5), PPM1G(2), PRPF3(2), PRPF4(2), PRPF8(5), PTBP1(3), PTBP2(2), RBM17(1), SF3A2(1), SF3B1(4), SF3B2(3), SF3B5(1), SNRPA(1), SNRPB2(1), SNRPE(2), SNRPN(2), SPOP(1), SRPK1(2), SRRM1(3), SUPT5H(2), U2AF1(2), U2AF2(1), XRN2(4) 23426986 116 46 112 33 37 18 16 20 22 3 0.328 1.000 1.000 522 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 85 BRAF(3), CHUK(1), CREB1(2), DAXX(3), ELK1(2), HRAS(1), IKBKB(4), MAP2K3(1), MAP2K4(5), MAP2K6(3), MAP2K7(3), MAP3K1(3), MAP3K10(2), MAP3K12(2), MAP3K13(1), MAP3K2(2), MAP3K4(2), MAP3K5(1), MAP3K6(1), MAP3K7(2), MAP3K9(6), MAP4K1(3), MAP4K2(3), MAP4K3(4), MAP4K4(2), MAP4K5(1), MAPK11(1), MAPK12(1), MAPK13(1), MAPK4(1), MAPK6(3), MAPK7(4), MAPK8(2), MAPK9(1), MAPKAPK3(1), MAPKAPK5(1), MAX(1), MEF2A(1), MEF2C(3), MEF2D(2), MKNK2(1), NFKBIA(1), PAK2(2), RELA(2), RPS6KA2(2), RPS6KA3(1), RPS6KA4(2), RPS6KA5(2), RPS6KB2(1), SHC1(1), SP1(1), STAT1(3), TGFB1(1), TGFBR1(8), TRADD(1), TRAF2(1) 21614029 116 45 115 37 29 27 23 12 25 0 0.298 1.000 1.000 523 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 109 A4GNT(1), ALG10(1), ALG10B(1), ALG11(2), ALG12(3), ALG13(1), ALG8(1), ALG9(1), B3GNT2(2), B3GNT6(2), B3GNT7(1), B4GALT2(1), B4GALT5(2), C1GALT1(1), CHPF(2), CHST1(1), CHST11(2), CHST12(1), CHST14(2), CHST2(2), CHST4(1), CHST6(2), DDOST(1), DPAGT1(2), EXT1(2), EXT2(4), EXTL1(3), EXTL2(4), EXTL3(6), GALNT1(3), GALNT10(5), GALNT13(2), GALNT2(2), GALNT5(4), GALNT6(2), GALNT7(2), GALNT8(1), GALNT9(1), GALNTL5(2), GANAB(3), HS2ST1(1), HS3ST2(3), HS6ST1(2), HS6ST2(1), MAN1A1(1), MAN1A2(1), MAN1B1(1), MAN1C1(1), MAN2A1(5), MGAT1(1), MGAT2(1), MGAT3(2), MGAT4B(1), MGAT5(2), MGAT5B(1), NDST1(3), NDST3(3), NDST4(2), OGT(4), ST3GAL1(2), ST3GAL2(1), ST3GAL4(2), ST6GAL1(1), ST6GALNAC1(1), WBSCR17(2), XYLT1(5), XYLT2(2) 24823060 134 44 132 42 45 23 32 15 19 0 0.164 1.000 1.000 524 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 70 ACACB(7), ACSL1(1), ACSL3(4), ACSL4(3), ACSL5(2), ACSL6(2), ADIPOR1(2), AKT1(1), AKT2(2), AKT3(2), CHUK(1), CPT1A(1), CPT1B(5), CPT1C(2), CPT2(1), G6PC2(1), IKBKB(4), IRS1(4), IRS2(4), IRS4(16), JAK1(1), JAK2(6), JAK3(3), LEPR(7), MAPK8(2), MAPK9(1), NFKB2(1), NFKBIA(1), NFKBIB(1), NFKBIE(1), NPY(2), PCK1(3), PCK2(2), POMC(1), PPARA(1), PPARGC1A(2), PRKAA1(2), PRKAA2(1), PRKAB1(1), PRKAB2(2), PRKAG3(4), PRKCQ(2), RELA(2), RXRA(1), RXRB(2), RXRG(1), SLC2A1(3), STAT3(2), STK11(3), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(1), TYK2(2) 18610036 133 44 121 42 34 27 17 16 38 1 0.280 1.000 1.000 525 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 73 CALML3(1), CDIPT(3), DGKA(1), DGKB(2), DGKD(2), DGKG(1), DGKH(3), DGKI(4), DGKQ(3), DGKZ(3), INPP4A(2), INPP4B(1), INPP5A(1), INPP5B(1), INPP5D(1), INPP5E(1), INPPL1(2), ITPKB(3), ITPR1(10), ITPR2(4), ITPR3(8), OCRL(1), PI4KA(4), PI4KB(1), PIK3C2A(5), PIK3C2B(10), PIK3C3(2), PIK3CA(4), PIK3CB(1), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PIP4K2A(2), PIP4K2C(1), PIP5K1B(2), PIP5K1C(1), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), PLCD1(1), PLCD3(1), PLCD4(3), PLCE1(5), PLCG1(1), PLCG2(7), PRKCG(2), SYNJ1(1), SYNJ2(3) 27988646 138 42 138 39 51 18 24 23 22 0 0.0377 1.000 1.000 526 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 110 ACTN1(1), ACTN2(4), ARHGAP5(5), BCAR1(2), CDC42(1), CDH5(2), CLDN17(3), CLDN22(1), CLDN3(2), CLDN9(2), CTNNA1(4), CTNNA2(5), CTNNA3(5), CTNNB1(7), CTNND1(2), CXCR4(3), CYBB(1), ESAM(1), F11R(1), GNAI1(1), GNAI2(1), ICAM1(2), ITGA4(1), ITGAL(2), ITGAM(4), ITGB2(1), ITK(1), JAM2(2), MAPK11(1), MAPK12(1), MAPK13(1), MLLT4(4), MMP2(2), MMP9(3), MYL9(1), NCF2(1), NOX1(2), NOX3(1), PIK3CA(4), PIK3CB(1), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PLCG1(1), PLCG2(7), PRKCG(2), PTK2(3), PXN(1), RAC2(1), RAP1B(3), RAPGEF3(3), RAPGEF4(3), RHOA(1), RHOH(2), ROCK1(5), ROCK2(2), SIPA1(3), THY1(1), TXK(1), VAV1(4), VCL(1) 27837328 145 42 144 58 47 29 19 24 24 2 0.616 1.000 1.000 527 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(1), AKT3(2), BCAR1(2), CAPN1(1), CAPN11(2), CAPN3(4), CAPN5(3), CAPN6(2), CAPN9(1), CAPNS1(2), CDC42(1), CRK(1), CSK(1), DOCK1(4), GIT2(2), ILK(1), ITGA2(2), ITGA3(1), ITGA4(1), ITGA5(1), ITGA6(4), ITGA7(6), ITGA8(2), ITGAD(2), ITGAE(3), ITGAL(2), ITGAM(4), ITGAV(3), ITGAX(3), ITGB2(1), ITGB3(1), ITGB4(7), ITGB5(3), ITGB6(3), ITGB8(4), MAP2K3(1), MAP2K6(3), MAPK12(1), MAPK4(1), MAPK6(3), MAPK7(4), MYLK2(4), PAK2(2), PAK4(1), PAK6(1), PIK3R2(2), PTK2(3), PXN(1), RAC2(1), RAP1B(3), ROCK1(5), ROCK2(2), SDCCAG8(2), SEPP1(1), SHC1(1), SORBS1(2), SOS1(2), SRC(2), TLN1(12), TNS1(4), VCL(1), ZYX(1) 30081152 149 42 148 45 41 33 30 17 27 1 0.0774 1.000 1.000 528 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 82 ACVR1B(2), ACVRL1(1), AKT1(1), BMPR1A(3), BMPR2(3), BUB1(3), CDIPT(3), CDKL1(1), CLK1(3), CLK2(1), CLK4(2), COL4A3BP(1), CSNK2A1(1), DGKA(1), DGKB(2), DGKD(2), DGKG(1), DGKH(3), DGKQ(3), DGKZ(3), INPP4A(2), INPP4B(1), INPP5A(1), INPPL1(2), ITPKB(3), MAP3K10(2), MOS(3), OCRL(1), PAK4(1), PIK3C2A(5), PIK3C2B(10), PIK3CA(4), PIK3CB(1), PIK3CG(4), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), PLCD1(1), PLCG1(1), PLCG2(7), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PRKCD(4), PRKCE(1), PRKCG(2), PRKCH(1), PRKCQ(2), PRKG1(1), RPS6KA2(2), RPS6KA3(1), RPS6KA4(2), STK11(3), TGFBR1(8), VRK1(1) 25403431 136 42 136 40 48 21 22 25 20 0 0.113 1.000 1.000 529 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 56 BMP2(1), BMP4(2), BMP5(2), BMP7(1), BMP8B(1), BTRC(2), CSNK1A1L(4), CSNK1D(1), CSNK1E(1), CSNK1G3(2), DHH(2), FBXW11(1), GLI1(4), GLI2(4), GLI3(10), GSK3B(2), HHIP(4), LRP2(7), PRKACB(1), PRKACG(3), PTCH1(5), PTCH2(6), SMO(1), SUFU(1), WNT1(1), WNT10A(1), WNT11(1), WNT2(3), WNT2B(3), WNT3A(4), WNT5A(5), WNT6(1), WNT7A(2), WNT7B(2), WNT8A(2), ZIC2(2) 13726910 95 40 94 33 39 21 15 11 9 0 0.167 1.000 1.000 530 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 59 APC(7), AXIN1(3), CCND2(3), CCND3(1), CSNK1E(1), CTNNB1(7), DVL1(4), DVL2(4), DVL3(1), FBXW2(1), FOSL1(1), FZD1(5), FZD10(4), FZD2(2), FZD3(3), FZD7(2), FZD8(1), FZD9(2), GSK3B(2), LDLR(1), MAPK9(1), PAFAH1B1(1), PPP2R5C(3), PPP2R5E(1), PRKCD(4), PRKCE(1), PRKCG(2), PRKCH(1), PRKCI(4), PRKCQ(2), RHOA(1), SFRP4(1), TCF7(1), WNT1(1), WNT10A(1), WNT11(1), WNT2(3), WNT2B(3), WNT5A(5), WNT6(1), WNT7A(2), WNT7B(2) 13542061 97 40 95 31 42 22 11 16 6 0 0.0499 1.000 1.000 531 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 98 AKT1(1), AKT2(2), AKT3(2), CASP8(2), CCL3(1), CD14(1), CD40(1), CD80(2), CD86(6), CHUK(1), IFNA10(1), IFNA16(1), IFNA7(2), IFNAR1(2), IFNAR2(2), IKBKB(4), IKBKE(1), IL12B(1), IL1B(1), IL6(1), IRAK4(1), IRF3(2), IRF5(1), IRF7(2), LBP(1), LY96(1), MAP2K3(1), MAP2K4(5), MAP2K6(3), MAP2K7(3), MAP3K7(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK8(2), MAPK9(1), NFKB2(1), NFKBIA(1), PIK3CA(4), PIK3CB(1), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), RELA(2), STAT1(3), TBK1(1), TICAM1(2), TLR1(4), TLR2(3), TLR3(2), TLR4(1), TLR5(2), TLR6(4), TLR8(2), TLR9(6), TRAF6(1) 19946465 115 39 113 32 30 17 20 20 27 1 0.126 1.000 1.000 532 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 53 ADORA3(6), CCKBR(3), CCR2(1), CELSR1(4), CELSR2(9), CELSR3(10), CHRM2(3), CHRM3(1), CIDEB(1), EMR2(1), EMR3(1), FSHR(3), GHRHR(1), GNRHR(1), GPR116(3), GPR133(7), GPR135(1), GPR143(1), GPR18(1), GPR56(1), GPR61(1), GPR84(1), GRM1(9), GRPR(1), LGR6(3), LPHN2(8), LPHN3(1), LTB4R2(1), OR2M4(2), P2RY13(3), PTGFR(2), SMO(1), TAAR5(2), TSHR(3), VN1R1(1) 14910030 98 34 98 35 37 20 19 13 9 0 0.111 1.000 1.000 533 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(10), B3GALT4(2), CDR1(1), DGKI(4), IL6ST(3), RPL11(1), RPL12(1), RPL14(1), RPL15(2), RPL18(2), RPL18A(1), RPL19(1), RPL22(5), RPL28(2), RPL32(1), RPL34(1), RPL35(1), RPL36(1), RPL3L(2), RPL4(3), RPL6(1), RPL7A(2), RPLP2(1), RPS11(2), RPS12(1), RPS25(1), RPS27(1), RPS27A(1), RPS28(1), RPS6KA2(2), RPS6KA3(1), RPS6KA6(4), RPS6KB2(1), RPSA(1), TSPAN9(1), UBB(1) 11673835 67 34 63 28 12 10 17 8 19 1 0.910 1.000 1.000 534 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(2), ALPL(2), ALPP(3), ALPPL2(4), ASCC3(5), ATP13A2(1), DDX18(1), DDX23(1), DDX4(8), DDX41(2), DDX47(5), DDX50(3), DDX51(1), DDX52(1), DDX54(2), DDX55(1), DDX56(2), DHFR(1), DHX58(4), EP400(2), ERCC2(2), ERCC3(3), FPGS(3), GCH1(1), GGH(2), IFIH1(5), MOV10L1(5), NUDT8(1), QDPR(2), RAD54B(2), RAD54L(5), RUVBL2(3), SETX(3), SKIV2L2(2), SMARCA2(3), SMARCA5(1) 13983542 94 30 92 37 23 21 16 13 19 2 0.756 1.000 1.000 535 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 42 AKT1(1), ASAH1(1), ATF1(1), BRAF(3), CAMP(2), CREB1(2), CREB5(1), CREBBP(3), CRKL(1), DAG1(1), EGR1(4), EGR3(2), ELK1(2), GNAQ(1), MAP1B(6), MAP2K4(5), MAP2K7(3), MAPK8(2), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(4), MAPK9(1), NTRK1(2), OPN1LW(1), PIK3CA(4), PIK3CD(2), PIK3R1(1), RPS6KA3(1), SHC1(1), SRC(2), TERF2IP(1), TH(1) 11664352 64 28 64 24 18 9 14 11 12 0 0.581 1.000 1.000 536 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 92 ACTB(1), BAD(1), CABIN1(3), CAMK4(1), CD3E(1), CREBBP(3), CSNK2A1(1), EGR3(2), EP300(6), FCER1A(1), FOSL1(1), GATA3(3), GATA4(1), GSK3A(1), GSK3B(2), HRAS(1), IL1B(1), IL6(1), ITK(1), JUNB(1), KPNA5(2), MAP2K7(3), MAPK8(2), MAPK9(1), MEF2A(1), MEF2D(2), MYF5(2), NCK2(2), NFAT5(4), NFATC1(4), NFATC2(3), NFATC3(2), NFATC4(5), NFKB2(1), NFKBIB(1), NFKBIE(1), NUP214(4), OPRD1(2), P2RX7(1), PPIA(2), PPP3CC(1), PPP3R1(1), PTPRC(2), RELA(2), SLA(1), SP1(1), SP3(1), TGFB1(1), TRAF2(1), TRPV6(6), VAV1(4), XPO5(2) 20277803 101 27 101 33 33 24 13 11 19 1 0.209 1.000 1.000 537 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 47 INPP4A(2), INPP4B(1), INPP5A(1), INPP5B(1), INPP5E(1), INPPL1(2), ISYNA1(1), ITPKB(3), MIOX(1), OCRL(1), PI4KA(4), PI4KB(1), PIK3C3(2), PIK3CA(4), PIK3CB(1), PIK3CD(2), PIK3CG(4), PIP4K2A(2), PIP4K2C(1), PIP5K1B(2), PIP5K1C(1), PLCB1(1), PLCB2(4), PLCB3(4), PLCB4(2), PLCD1(1), PLCD3(1), PLCD4(3), PLCE1(5), PLCG1(1), PLCG2(7), SYNJ1(1), SYNJ2(3) 16625380 71 27 71 24 23 10 13 14 11 0 0.311 1.000 1.000 538 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 44 AKT1(1), AKT2(2), AKT3(2), BRAF(3), CAB39(1), DDIT4(1), EIF4B(3), HIF1A(1), PIK3CA(4), PIK3CB(1), PIK3CD(2), PIK3CG(4), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PRKAA1(2), PRKAA2(1), RHEB(1), RICTOR(6), RPS6KA2(2), RPS6KA3(1), RPS6KA6(4), RPS6KB2(1), STK11(3), TSC1(2), TSC2(6), ULK1(3), ULK3(1) 11956964 64 27 64 22 17 14 11 7 15 0 0.545 1.000 1.000 539 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1A(3), ADH1B(1), ADH4(1), ADH5(2), ADH6(2), ADH7(3), ADHFE1(4), AGPAT1(1), AGPAT3(2), AGPAT4(3), AKR1A1(1), AKR1B1(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(1), CEL(1), DGAT1(3), DGKA(1), DGKB(2), DGKD(2), DGKG(1), DGKH(3), DGKI(4), DGKQ(3), DGKZ(3), GK2(4), GLB1(2), GPAM(4), LCT(5), LIPA(1), LIPF(2), LIPG(4), LPL(3), MGLL(2), PNLIP(2), PPAP2B(2), PPAP2C(1) 13111026 83 24 83 31 33 15 12 10 12 1 0.293 1.000 1.000 540 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(3), GTF2A1(1), GTF2E1(2), GTF2F1(1), NCOA2(3), NCOA3(16), NCOR2(3), POLR2A(5), RXRA(1), TBP(1) 5593584 36 24 26 15 7 3 6 2 17 1 0.979 1.000 1.000 541 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 ARNTL(1), AZIN1(1), BTG1(1), CBX3(4), CLOCK(3), CRY1(1), CRY2(1), DNAJA1(2), EIF4G2(1), ETV6(1), GFRA1(3), GSTP1(1), HERPUD1(2), HSPA8(2), IDI1(1), MYF6(1), NCKAP1(5), NCOA4(1), NR1D2(1), PER1(3), PER2(5), PPP1R3C(2), PURA(1), TUBB3(2), UCP3(1), UGP2(3) 8164695 50 23 46 21 10 8 6 13 12 1 0.895 1.000 1.000 542 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 ADAM17(4), APH1A(2), CREBBP(3), CTBP2(3), DLL1(2), DLL4(2), DTX1(3), DTX2(4), DVL1(4), DVL2(4), DVL3(1), EP300(6), JAG1(1), JAG2(3), LFNG(1), MAML1(2), MAML2(3), MAML3(1), NCOR2(3), NOTCH1(9), NOTCH2(6), NOTCH3(7), NOTCH4(5), NUMBL(2), PSEN1(1), PSEN2(1), RBPJ(2), RBPJL(1), SNW1(1) 15905075 87 23 86 39 28 23 17 10 9 0 0.633 1.000 1.000 543 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AADAT(2), AASS(2), ACAT1(2), ACAT2(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(1), DOT1L(1), EHHADH(1), EHMT1(3), EHMT2(3), GCDH(2), HADH(1), HADHA(1), HSD17B4(3), HSD3B7(3), NSD1(6), OGDH(5), OGDHL(1), PLOD1(2), RDH11(2), SETD1A(3), SETDB1(3), SHMT1(1), SHMT2(3), SPCS1(1), SUV39H2(3), TMLHE(1) 12896478 60 22 60 22 18 10 12 7 13 0 0.574 1.000 1.000 544 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(3), ADH1B(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(4), AGPAT1(1), AGPAT3(2), AGPAT4(3), AKR1A1(1), AKR1B1(1), ALDH1A1(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(1), CEL(1), DGAT1(3), DGKA(1), DGKB(2), DGKD(2), DGKG(1), DGKH(3), DGKQ(3), DGKZ(3), GLB1(2), LCT(5), LIPF(2), LIPG(4), LPL(3), PNLIP(2), PPAP2B(2), PPAP2C(1) 10793573 67 21 67 27 31 8 8 8 11 1 0.432 1.000 1.000 545 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 CHIA(1), CHIT1(3), CYB5R1(3), CYB5R3(2), GFPT1(2), GFPT2(2), GNE(1), GNPDA1(2), HEXA(2), HEXB(2), HK1(4), HK2(6), HK3(4), MTMR2(2), MTMR6(2), NAGK(1), NANS(1), PHPT1(1), RENBP(1), UAP1(1) 6355090 43 20 43 15 16 4 8 3 12 0 0.734 1.000 1.000 546 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1A(3), ADRA1D(1), ADRA2A(1), ADRA2C(2), ADRB2(1), CHRM1(1), CHRM2(3), CHRM3(1), CHRM5(3), DRD1(5), DRD5(2), HRH2(1), HTR1A(3), HTR1D(2), HTR1F(1), HTR2A(3), HTR2B(1), HTR2C(5), HTR4(1), HTR5A(4), HTR7(1) 5787722 45 20 44 19 17 6 11 7 3 1 0.636 1.000 1.000 547 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(1), CAMK2D(1), GNA11(2), GNAI1(1), GNB1(3), HRAS(1), JAK2(6), MAPK8(2), MAPT(3), MYLK(13), PLCG1(1), SHC1(1), SOS1(2), STAT1(3), STAT3(2), STAT5A(1), SYT1(2) 9255162 45 18 43 16 13 8 5 6 12 1 0.643 1.000 1.000 548 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(1), B4GALT2(1), FBP2(1), GAA(2), GANAB(3), GCK(1), GLB1(2), HK1(4), HK2(6), HK3(4), LCT(5), MGAM(1), PFKM(3), PGM1(1) 7245344 35 18 35 13 15 3 6 1 9 1 0.621 1.000 1.000 549 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 34 AKT1(1), BAD(1), CBL(3), CFLAR(3), CRKL(1), HRAS(1), IL2RB(2), IRS1(4), JAK1(1), JAK3(3), PIK3CA(4), PIK3R1(1), PPIA(2), PTPN6(4), SHC1(1), SOS1(2), STAT5A(1), SYK(2) 8064364 37 18 37 18 11 7 7 9 3 0 0.857 1.000 1.000 550 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 AKT1(1), AKT2(2), AKT3(2), BAD(1), BCR(2), BLNK(1), BTK(1), CD19(1), CSK(1), DAG1(1), EPHB2(4), ITPKB(3), NFAT5(4), NFKB2(1), NFKBIA(1), NFKBIB(1), NFKBIE(1), PIK3CA(4), PIK3CD(2), PIK3R1(1), PLCG2(7), SHC1(1), SOS1(2), SOS2(1), SYK(2), VAV1(4) 11730750 52 18 52 21 18 11 4 10 8 1 0.573 1.000 1.000 551 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 AGXT(2), AGXT2(1), ALAS1(1), ALAS2(3), AOC2(2), AOC3(3), CHDH(1), DAO(2), DMGDH(3), GARS(6), GLDC(1), HSD3B7(3), PHGDH(2), PSAT1(1), RDH11(2), SARDH(2), SARS2(3), SHMT1(1), SHMT2(3), TARS(2) 9549904 44 17 42 19 23 9 4 5 3 0 0.619 1.000 1.000 552 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(2), B4GALNT1(1), GLB1(2), HEXA(2), HEXB(2), LCT(5), ST3GAL1(2), ST3GAL2(1), ST3GAL5(1), ST6GALNAC3(2), ST6GALNAC4(1), ST6GALNAC5(3), ST6GALNAC6(2), ST8SIA1(2), ST8SIA5(3) 3634243 31 17 31 13 9 4 7 1 9 1 0.660 1.000 1.000 553 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 AGXT(2), AGXT2(1), ALAS1(1), ALAS2(3), AOC2(2), AOC3(3), ATP6V0C(1), CHDH(1), CPT1B(5), DAO(2), DMGDH(3), GARS(6), GLDC(1), PLCB2(4), PLCG1(1), PLCG2(7), SARDH(2), SHMT1(1), SHMT2(3), TARS(2) 9398882 51 16 51 20 20 12 7 5 7 0 0.526 1.000 1.000 554 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(1), AARS2(3), CARS2(2), DARS(1), EARS2(1), EPRS(1), FARS2(1), FARSA(1), FARSB(1), GARS(6), IARS(4), KARS(1), LARS2(1), MARS2(2), NARS2(1), PARS2(1), QARS(2), RARS(1), RARS2(3), SARS2(3), TARS(2), VARS(3), VARS2(2), WARS(2) 11944294 46 16 44 20 14 11 9 6 6 0 0.796 1.000 1.000 555 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 ATF1(1), BAD(1), BRAF(3), CREB1(2), CREB5(1), DUSP6(2), DUSP9(1), MKNK2(1), MOS(3), RPS6KA2(2), RPS6KA3(1), SHC1(1), SOS1(2), SOS2(1) 6593087 22 16 22 13 6 4 4 2 6 0 0.968 1.000 1.000 556 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CAMK1(2), CAMK1G(2), ELK1(2), FPR1(2), GNA15(3), GNB1(3), HRAS(1), MAP2K3(1), MAP2K6(3), MAP3K1(3), NCF2(1), NFATC1(4), NFATC2(3), NFATC3(2), NFATC4(5), NFKBIA(1), PLCB1(1), PPP3CA(2), PPP3CC(1), RELA(2), SYT1(2) 8558272 46 15 46 17 12 11 9 5 8 1 0.613 1.000 1.000 557 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 AANAT(1), ACHE(3), CHAT(4), DBH(1), DDC(1), GAD1(5), GAD2(7), PAH(1), SLC18A3(3), TH(1), TPH1(2) 3242722 29 14 29 12 10 2 9 2 5 1 0.617 1.000 1.000 558 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG10(1), ALG10B(1), ALG11(2), ALG12(3), ALG13(1), ALG5(1), ALG8(1), ALG9(1), B4GALT2(1), DDOST(1), DHDDS(1), DPAGT1(2), GANAB(3), MAN1A1(1), MAN1A2(1), MAN1B1(1), MAN1C1(1), MAN2A1(5), MGAT1(1), MGAT2(1), MGAT3(2), MGAT4B(1), MGAT5(2), MGAT5B(1), ST6GAL1(1) 9477580 37 14 37 13 11 10 6 6 4 0 0.480 1.000 1.000 559 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2A1(1), GTF2E1(2), GTF2F1(1), GTF2H1(1), GTF2H4(1), GTF2I(1), GTF2IRD1(2), STON1(2), TAF1(5), TAF1L(5), TAF2(1), TAF4(4), TAF4B(2), TAF5L(2), TAF6(1), TAF6L(3) 7951189 34 14 34 14 11 5 8 6 4 0 0.831 1.000 1.000 560 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 AKT1(1), EIF4A2(2), EIF4B(3), EIF4G1(8), EIF4G2(1), EIF4G3(5), FKBP1A(1), PDK2(3), PIK3CA(4), PIK3R1(1), PPP2CA(1), TSC1(2), TSC2(6) 6119033 38 14 38 12 10 7 11 6 4 0 0.561 1.000 1.000 561 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 CDK7(1), ERCC3(3), GTF2E1(2), GTF2H1(1), GTF2H4(1), ILK(1), POLR1A(3), POLR1B(3), POLR2A(5), POLR2B(4), POLR2E(1), POLR2G(1), POLR3B(3), POLR3E(4), TAF6(1), TBP(1) 7700770 35 14 34 12 14 5 8 2 6 0 0.573 1.000 1.000 562 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 CALCR(1), CD97(1), CRHR1(1), CRHR2(1), ELTD1(5), EMR1(3), EMR2(1), GHRHR(1), GIPR(1), GLP2R(3), GPR64(2), LPHN1(2), LPHN2(8), LPHN3(1), VIPR1(1), VIPR2(1) 5984683 33 13 33 15 6 8 5 9 5 0 0.710 1.000 1.000 563 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(2), AMD1(1), DNMT3A(7), DNMT3B(5), MARS2(2), MAT2B(2), MTR(4), TAT(1) 4592622 24 13 23 15 6 5 5 2 6 0 0.954 1.000 1.000 564 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 17 B3GAT1(1), B3GAT3(2), CHPF(2), CHST11(2), CHST12(1), CHST14(2), DSE(4), XYLT1(5), XYLT2(2) 3322385 21 13 21 11 9 3 7 2 0 0 0.638 1.000 1.000 565 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 AKR1C3(2), ALOX15(1), ALOX15B(1), ALOX5(1), CYP2B6(1), CYP2C18(3), CYP2C9(2), CYP2E1(1), CYP2J2(4), CYP2U1(1), CYP4A22(1), CYP4F2(2), DHRS4(1), EPHX2(1), GGT1(1), GPX5(3), GPX6(1), LTA4H(1), PLA2G1B(1), PLA2G3(1), PLA2G6(4), PTGDS(2), PTGES2(1), PTGIS(2), PTGS1(1), TBXAS1(1) 8674299 41 13 41 22 13 8 13 1 5 1 0.896 1.000 1.000 566 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(2), DNMT3A(7), DNMT3B(5), MARS2(2), MAT2B(2), MTR(4) 3847715 22 13 21 13 6 4 5 2 5 0 0.925 1.000 1.000 567 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 AGA(2), ARSB(2), FUCA2(1), GBA(3), GLB1(2), GNS(1), GUSB(1), HEXA(2), HEXB(2), HGSNAT(1), HPSE2(1), HYAL1(2), LCT(5), MAN2B1(1), MAN2B2(2), MANBA(1), NAGLU(2), NEU4(1) 7788790 32 12 32 16 10 5 7 3 6 1 0.817 1.000 1.000 568 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(6), ARRB2(2), CALML3(1), CAMK2D(1), CLCA1(2), CLCA2(1), CLCA4(2), CNGA3(4), CNGA4(2), CNGB1(4), GNAL(2), GUCA1A(1), GUCA1B(1), GUCA1C(1), PDE1C(1), PRKACB(1), PRKACG(3), PRKG1(1), PRKG2(1) 6767858 37 12 36 15 13 5 11 5 3 0 0.627 1.000 1.000 569 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(2), ALOX15(1), ALOX5(1), CYP4F2(2), EPX(4), GGT1(1), LPO(5), LTA4H(1), MPO(2), PLA2G1B(1), PLA2G3(1), PLA2G6(4), PRDX1(1), PTGDS(2), PTGES2(1), PTGIS(2), PTGS1(1), TBXAS1(1), TPO(7) 6201140 40 12 40 19 18 4 10 2 5 1 0.817 1.000 1.000 570 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BIRC2(2), CASP3(2), CASP8(2), CFLAR(3), MAP2K4(5), MAP3K7(2), NFKB2(1), NFKBIA(1), NFKBIB(1), NFKBIE(1), NR2C2(1), RALBP1(2), TNFAIP3(2), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF2(1) 6126545 30 12 30 12 9 3 6 6 6 0 0.746 1.000 1.000 571 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(2), IL22(1), IL22RA1(1), JAK1(1), JAK2(6), JAK3(3), STAT1(3), STAT3(2), STAT5A(1), TYK2(2) 4124985 22 11 21 10 7 2 4 2 7 0 0.894 1.000 1.000 572 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 CREBBP(3), EP300(6), IL7(1), IL7R(1), JAK1(1), JAK3(3), LCK(1), PIK3CA(4), PIK3R1(1), STAT5A(1) 6232929 22 11 22 10 7 3 5 4 3 0 0.768 1.000 1.000 573 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AADAT(2), AASDH(2), AASS(2), ACAT1(2), ACAT2(1), ALDH1A1(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(1), ATP6V0C(1), DOT1L(1), EHHADH(1), EHMT1(3), EHMT2(3), GCDH(2), HADHA(1), PLOD1(2), SHMT1(1), SHMT2(3), TMLHE(1) 8227578 33 11 33 17 11 6 8 0 8 0 0.877 1.000 1.000 574 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 ARFIP2(1), CDK5R1(1), MAP3K1(3), MYLK(13), NCF2(1), PDGFRA(3), PIK3CA(4), PIK3R1(1), RALBP1(2), TRIO(6), VAV1(4), WASF1(1) 7721511 40 11 39 15 13 8 6 7 4 2 0.598 1.000 1.000 575 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(1), DARS(1), EPRS(1), FARS2(1), GARS(6), IARS(4), KARS(1), LARS2(1), MARS2(2), QARS(2), RARS(1), TARS(2), WARS(2) 7010918 25 10 25 10 7 6 5 5 2 0 0.701 1.000 1.000 576 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(4), LCT(5), PGM1(1), PYGL(2), PYGM(1), TPI1(3) 2997589 16 10 16 11 6 3 1 1 4 1 0.929 1.000 1.000 577 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(1), IL4R(3), IRS1(4), JAK1(1), JAK3(3), SHC1(1), STAT6(5) 3305550 18 10 18 10 7 5 2 3 1 0 0.804 1.000 1.000 578 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 CSNK2A1(1), ELK1(2), HRAS(1), IL6(1), IL6R(1), IL6ST(3), JAK1(1), JAK2(6), JAK3(3), SHC1(1), SOS1(2), SRF(1), STAT3(2) 5347817 25 10 24 14 5 4 3 3 10 0 0.979 1.000 1.000 579 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(3), EP300(6), LPL(3), NCOA2(3), PPARG(1), RXRA(1) 4068132 17 10 17 10 6 2 3 2 4 0 0.925 1.000 1.000 580 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(2), CRKL(1), GNAQ(1), HRAS(1), MAP2K3(1), MAP2K4(5), MAP3K1(3), MAPK8(2), PLCG1(1), SHC1(1), SOS1(2), SRC(2), SYT1(2) 6351147 24 10 24 12 6 5 3 5 4 1 0.860 1.000 1.000 581 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 CISH(1), IL6(1), IL6R(1), JAK1(1), JAK2(6), JAK3(3), PIAS3(1), PTPRU(6), REG1A(1), SRC(2), STAT3(2) 3408766 25 10 23 13 8 5 5 0 7 0 0.909 1.000 1.000 582 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA1(1), ADH1A(3), ADH1B(1), ADH4(1), ADH6(2), ADH7(3), ADHFE1(4), ALDH1A1(1), ALDH1A3(2), ALDH3A1(1), ALDH3A2(1), BAAT(1), CEL(1), CYP27A1(2), CYP7A1(2), HADHB(2) 5149431 28 9 28 13 9 6 5 3 5 0 0.759 1.000 1.000 583 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 BCAR1(2), CRK(1), CXCR4(3), GNAI1(1), GNAQ(1), GNB1(3), HRAS(1), PIK3CA(4), PIK3R1(1), PLCG1(1), PTK2(3), PXN(1), RELA(2) 6226784 24 9 24 13 6 7 3 4 4 0 0.893 1.000 1.000 584 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(3), CD2(3), CD33(3), CD5(1), IL12B(1), ITGAX(3), TLR2(3), TLR4(1), TLR9(6) 4101440 24 9 24 10 8 4 2 5 5 0 0.766 1.000 1.000 585 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(2), GLB1(2), GNS(1), GUSB(1), HEXA(2), HEXB(2), HGSNAT(1), HPSE2(1), HYAL1(2), LCT(5), NAGLU(2) 4613318 21 9 21 13 5 5 3 2 5 1 0.930 1.000 1.000 586 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 ALOX15(1), ALOX5(1), CYP1A2(4), CYP2C18(3), CYP2C9(2), CYP2E1(1), CYP2J2(4), CYP3A5(1), CYP3A7(2), HSD3B7(3), PLA2G1B(1), PLA2G3(1), PLA2G6(4), RDH11(2) 5277633 30 9 30 11 7 4 11 6 2 0 0.683 1.000 1.000 587 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG5(1), B4GALT2(1), B4GALT5(2), DDOST(1), DPAGT1(2), MAN1A1(1), MAN1B1(1), MGAT1(1), MGAT2(1), MGAT3(2), MGAT4B(1), MGAT5(2), ST6GAL1(1) 4445849 17 9 17 10 7 3 2 4 1 0 0.891 1.000 1.000 588 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 BCR(2), BLNK(1), ELK1(2), HRAS(1), MAP3K1(3), MAPK8IP3(4), PAPPA(3), RPS6KA3(1), SHC1(1), SOS1(2), SYK(2), VAV1(4) 7165978 26 9 26 11 9 4 4 4 4 1 0.729 1.000 1.000 589 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 CISH(1), JAK1(1), JAK2(6), JAK3(3), PIAS1(1), PIAS3(1), PTPRU(6), REG1A(1), SOAT1(1) 3084396 21 9 19 12 8 2 5 0 6 0 0.959 1.000 1.000 590 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CHUK(1), EGR3(2), GNAQ(1), MAP3K1(3), NFATC1(4), NFATC2(3), NFKBIA(1), PLCG1(1), PPP3CA(2), PPP3CC(1), PRKACB(1), PRKACG(3), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), RELA(2), SYT1(2), VIPR2(1) 6204845 32 9 32 12 10 7 4 5 5 1 0.518 1.000 1.000 591 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(2), HS3ST2(3), XYLT1(5), XYLT2(2) 1519291 12 8 12 13 5 4 2 1 0 0 0.965 1.000 1.000 592 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(2), HS3ST2(3), XYLT1(5), XYLT2(2) 1519291 12 8 12 13 5 4 2 1 0 0 0.965 1.000 1.000 593 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 37 ANPEP(3), GCLC(1), GCLM(1), GGT1(1), GPX5(3), GPX6(1), GSR(1), GSTA2(1), GSTA3(1), GSTA4(1), GSTA5(2), GSTM2(1), GSTM5(2), GSTO2(1), GSTP1(1), IDH1(1), IDH2(5), MGST2(1), OPLAH(3) 5051763 31 8 31 16 8 8 7 3 5 0 0.700 1.000 1.000 594 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(2), GGT1(1), MARS2(2), MAT2B(2), PAPSS1(2), PAPSS2(6), SCLY(2) 2745703 17 8 16 11 4 4 2 1 6 0 0.952 1.000 1.000 595 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 31 ANPEP(3), GCLC(1), GCLM(1), GGT1(1), GPX5(3), GSTA2(1), GSTA3(1), GSTA4(1), GSTM2(1), GSTM5(2), GSTO2(1), GSTP1(1), IDH1(1), IDH2(5), MGST2(1), PGD(1) 4082331 25 7 25 13 6 6 4 4 5 0 0.745 1.000 1.000 596 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 CHUK(1), IKBKB(4), MAP3K1(3), MAP3K7(2), NFKBIA(1), RELA(2), TLR4(1), TNFAIP3(2), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF6(1) 5481205 21 7 21 11 5 3 7 4 2 0 0.925 1.000 1.000 597 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCL3(1), CCR1(1), CCR2(1), CCR4(3), CCR7(1), CD4(2), CXCR4(3), IFNGR1(2), IL12B(1), IL4R(3), TGFB1(1) 4437256 19 7 19 10 4 4 4 4 3 0 0.817 1.000 1.000 598 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX15(1), ALOX15B(1), ALOX5(1), DPEP1(1), GGT1(1), LTA4H(1), PLA2G6(4), PTGDS(2), PTGIS(2), PTGS1(1), TBXAS1(1) 3375438 16 5 16 10 7 2 4 1 2 0 0.888 1.000 1.000 599 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT1(1), AGPAT3(2), AGPAT4(3), AGPS(1), ENPP2(3), PAFAH1B1(1), PAFAH1B3(1), PAFAH2(2), PLA2G1B(1), PLA2G3(1), PLA2G6(4), PLD2(4), PPAP2B(2), PPAP2C(1) 5143305 27 5 26 12 9 3 6 4 5 0 0.801 1.000 1.000 600 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 SNAP23(2), SNAP29(3), STX11(2), STX12(1), STX3(1), STX4(2), STX7(1), VAMP4(1), VAMP7(1), VTI1A(1) 3725679 15 5 15 13 8 0 2 1 4 0 0.994 1.000 1.000 601 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(1), ELK1(2), HRAS(1), IL2RB(2), JAK1(1), JAK3(3), LCK(1), MAPK8(2), SHC1(1), SOS1(2), STAT5A(1), SYK(2) 5252525 19 5 19 10 7 5 1 3 3 0 0.819 1.000 1.000 602 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 CHUK(1), IKBKAP(3), IKBKB(4), MAP3K1(3), NFKBIA(1), RELA(2), TNFAIP3(2), TNFRSF1B(1), TRAF2(1) 4986016 18 5 18 10 3 5 6 2 2 0 0.904 1.000 1.000 603 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(4), CYP2E1(1), NR1I3(1), PTGS1(1) 1162098 7 3 7 5 5 1 0 1 0 0 0.915 1.000 1.000 604 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GSR(1), NOX1(2), RELA(2), XDH(5) 2207882 10 3 10 7 3 2 3 2 0 0 0.949 1.000 1.000 605 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(2), PNPO(1), PSAT1(1) 1069690 4 3 4 3 1 0 3 0 0 0 0.907 1.000 1.000 606 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(2), HRAS(1), NFKBIA(1), PLCB1(1), RELA(2) 3428502 7 2 7 5 2 2 2 1 0 0 0.953 1.000 1.000 607 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IL12B(1), IL16(1), IL6(1), IL9(1) 2184111 4 2 4 3 0 2 1 1 0 0 0.838 1.000 1.000 608 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(1), IL12B(1) 658864 2 2 2 2 0 2 0 0 0 0 0.927 1.000 1.000 609 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 PLCD1(1), TGM2(1) 1096974 2 2 2 2 2 0 0 0 0 0 0.893 1.000 1.000 610 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(1), PLCG1(1) 1487161 2 1 2 4 1 1 0 0 0 0 0.984 1.000 1.000 611 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(1) 373143 1 1 1 2 0 0 1 0 0 0 0.995 1.000 1.000 612 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(3), CKM(3), FBL(1), GPT(1), LDHB(1) 2003358 9 1 9 6 2 1 5 1 0 0 0.923 1.000 1.000 613 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 663531 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 614 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 918008 0 0 0 2 0 0 0 0 0 0 1.000 1.000 1.000 615 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 110666 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 616 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 333709 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000