Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
PDGFR-alpha signaling pathway	63.0	2800.0	44.0	-0.24	0.022	1000.0	-1000.0	-0.013	-1000.0
Noncanonical Wnt signaling pathway	55.0	1430.0	26.0	-0.334	0.011	1000.0	-1000.0	-0.018	-1000.0
Wnt signaling	51.0	359.0	7.0	-0.334	0.011	1000.0	-1000.0	-0.014	-1000.0
IL23-mediated signaling events	39.0	2351.0	60.0	-0.603	0.024	1000.0	-1000.0	-0.069	-1000.0
Ras signaling in the CD4+ TCR pathway	39.0	671.0	17.0	-0.295	0.02	1000.0	-1000.0	-0.008	-1000.0
Thromboxane A2 receptor signaling	32.0	3447.0	105.0	-0.319	0.083	1000.0	-1000.0	-0.03	-1000.0
Signaling mediated by p38-alpha and p38-beta	31.0	1381.0	44.0	-0.283	0.011	1000.0	-1000.0	-0.014	-1000.0
mTOR signaling pathway	30.0	1617.0	53.0	-0.177	0.082	1000.0	-1000.0	-0.021	-1000.0
EGFR-dependent Endothelin signaling events	30.0	632.0	21.0	-0.151	0.016	1000.0	-1000.0	-0.011	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	29.0	1513.0	52.0	-0.251	0.013	1000.0	-1000.0	-0.016	-1000.0
Syndecan-1-mediated signaling events	26.0	886.0	34.0	-0.094	0.011	1000.0	-1000.0	-0.012	-1000.0
Integrins in angiogenesis	26.0	2264.0	84.0	-0.316	0.027	1000.0	-1000.0	-0.021	-1000.0
Signaling events mediated by the Hedgehog family	25.0	1337.0	52.0	-0.259	0.185	1000.0	-1000.0	-0.013	-1000.0
Syndecan-3-mediated signaling events	22.0	791.0	35.0	-0.209	0.032	1000.0	-1000.0	-0.01	-1000.0
IL6-mediated signaling events	21.0	1580.0	75.0	-0.291	0.022	1000.0	-1000.0	-0.012	-1000.0
Insulin Pathway	20.0	1524.0	74.0	-0.318	0.072	1000.0	-1000.0	-0.026	-1000.0
IL1-mediated signaling events	19.0	1226.0	62.0	-0.24	0.03	1000.0	-1000.0	-0.022	-1000.0
HIF-1-alpha transcription factor network	18.0	1402.0	76.0	-0.18	0.062	1000.0	-1000.0	-0.041	-1000.0
Glypican 1 network	18.0	888.0	48.0	-0.293	0.022	1000.0	-1000.0	-0.006	-1000.0
Glucocorticoid receptor regulatory network	18.0	2054.0	114.0	-0.578	0.159	1000.0	-1000.0	-0.036	-1000.0
amb2 Integrin signaling	17.0	1404.0	82.0	-0.244	0.014	1000.0	-1000.0	-0.019	-1000.0
Arf6 signaling events	16.0	1037.0	62.0	-0.191	0.026	1000.0	-1000.0	-0.012	-1000.0
IL12-mediated signaling events	15.0	1378.0	87.0	-0.183	0.029	1000.0	-1000.0	-0.08	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	14.0	490.0	34.0	-0.054	0.011	1000.0	-1000.0	-0.012	-1000.0
TCGA08_rtk_signaling	14.0	377.0	26.0	-0.237	0.011	1000.0	-1000.0	-0.005	-1000.0
FOXA2 and FOXA3 transcription factor networks	13.0	633.0	46.0	-0.975	0.208	1000.0	-1000.0	-0.012	-1000.0
Cellular roles of Anthrax toxin	12.0	485.0	39.0	-0.143	0.011	1000.0	-1000.0	-0.011	-1000.0
Plasma membrane estrogen receptor signaling	12.0	1096.0	86.0	-0.135	0.067	1000.0	-1000.0	-0.035	-1000.0
Syndecan-2-mediated signaling events	11.0	772.0	69.0	-0.209	0.024	1000.0	-1000.0	-0.003	-1000.0
Ephrin A  reverse signaling	10.0	73.0	7.0	-0.0	0.059	1000.0	-1000.0	-0.0	-1000.0
Signaling events mediated by PTP1B	10.0	813.0	76.0	-0.218	0.042	1000.0	-1000.0	-0.019	-1000.0
LPA receptor mediated events	10.0	1080.0	102.0	-0.309	0.11	1000.0	-1000.0	-0.05	-1000.0
IGF1 pathway	10.0	598.0	57.0	-0.113	0.053	1000.0	-1000.0	-0.017	-1000.0
Coregulation of Androgen receptor activity	9.0	696.0	76.0	-0.223	0.039	1000.0	-1000.0	-0.025	-1000.0
IL4-mediated signaling events	9.0	862.0	91.0	-0.303	0.384	1000.0	-1000.0	-0.114	-1000.0
BMP receptor signaling	9.0	787.0	81.0	-0.343	0.032	1000.0	-1000.0	-0.03	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	9.0	354.0	37.0	-0.149	0.027	1000.0	-1000.0	-0.01	-1000.0
Retinoic acid receptors-mediated signaling	9.0	563.0	58.0	-0.251	0.033	1000.0	-1000.0	-0.019	-1000.0
Nongenotropic Androgen signaling	9.0	504.0	52.0	-0.057	0.079	1000.0	-1000.0	-0.011	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	9.0	661.0	68.0	-0.29	0.06	1000.0	-1000.0	-0.045	-1000.0
S1P1 pathway	8.0	289.0	36.0	-0.115	0.023	1000.0	-1000.0	-0.018	-1000.0
Reelin signaling pathway	7.0	398.0	56.0	-0.018	0.35	1000.0	-1000.0	-0.016	-1000.0
HIF-2-alpha transcription factor network	7.0	335.0	43.0	-0.161	0.056	1000.0	-1000.0	-0.036	-1000.0
Syndecan-4-mediated signaling events	7.0	519.0	67.0	-0.104	0.013	1000.0	-1000.0	-0.02	-1000.0
E-cadherin signaling in keratinocytes	7.0	343.0	43.0	-0.151	0.026	1000.0	-1000.0	-0.01	-1000.0
Nectin adhesion pathway	6.0	408.0	63.0	-0.362	0.029	1000.0	-1000.0	-0.025	-1000.0
TRAIL signaling pathway	6.0	318.0	48.0	-0.064	0.026	1000.0	-1000.0	-0.024	-1000.0
Endothelins	6.0	641.0	96.0	-0.1	0.064	1000.0	-1000.0	-0.017	-1000.0
FAS signaling pathway (CD95)	6.0	311.0	47.0	-0.335	0.02	1000.0	-1000.0	-0.013	-1000.0
IL2 signaling events mediated by PI3K	6.0	361.0	58.0	-0.119	0.018	1000.0	-1000.0	-0.017	-1000.0
Calcium signaling in the CD4+ TCR pathway	6.0	207.0	31.0	-0.08	0.011	1000.0	-1000.0	-0.02	-1000.0
Angiopoietin receptor Tie2-mediated signaling	6.0	564.0	88.0	-0.318	0.083	1000.0	-1000.0	-0.047	-1000.0
Circadian rhythm pathway	5.0	125.0	22.0	-0.101	0.011	1000.0	-1000.0	-0.023	-1000.0
Canonical Wnt signaling pathway	5.0	260.0	51.0	-0.187	0.059	1000.0	-1000.0	-0.023	-1000.0
Regulation of nuclear SMAD2/3 signaling	4.0	631.0	136.0	-0.251	0.156	1000.0	-1000.0	-0.017	-1000.0
Fc-epsilon receptor I signaling in mast cells	4.0	413.0	97.0	-0.075	0.026	1000.0	-1000.0	-0.031	-1000.0
FoxO family signaling	4.0	300.0	64.0	-0.298	0.031	1000.0	-1000.0	-0.01	-1000.0
Paxillin-dependent events mediated by a4b1	4.0	149.0	36.0	-0.149	0.027	1000.0	-1000.0	-0.014	-1000.0
Effects of Botulinum toxin	4.0	107.0	26.0	-0.0	0.037	1000.0	-1000.0	-0.009	-1000.0
BCR signaling pathway	4.0	486.0	99.0	-0.133	0.061	1000.0	-1000.0	-0.034	-1000.0
PDGFR-beta signaling pathway	4.0	395.0	97.0	-0.101	0.027	1000.0	-1000.0	-0.028	-1000.0
Visual signal transduction: Rods	4.0	214.0	52.0	-0.036	0.061	1000.0	-1000.0	-0.014	-1000.0
FOXM1 transcription factor network	4.0	249.0	51.0	-0.026	0.066	1000.0	-1000.0	-0.078	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	4.0	381.0	78.0	-0.05	0.049	1000.0	-1000.0	-0.017	-1000.0
Regulation of Androgen receptor activity	4.0	340.0	70.0	-0.284	0.039	1000.0	-1000.0	-0.022	-1000.0
ErbB4 signaling events	3.0	266.0	69.0	-0.168	0.083	1000.0	-1000.0	-0.026	-1000.0
Presenilin action in Notch and Wnt signaling	3.0	212.0	61.0	-0.194	0.032	1000.0	-1000.0	-0.026	-1000.0
Arf6 downstream pathway	3.0	151.0	43.0	-0.048	0.023	1000.0	-1000.0	-0.013	-1000.0
EPO signaling pathway	3.0	175.0	55.0	-0.043	0.034	1000.0	-1000.0	-0.016	-1000.0
Ceramide signaling pathway	3.0	258.0	76.0	-0.107	0.023	1000.0	-1000.0	-0.017	-1000.0
Signaling events mediated by HDAC Class III	3.0	128.0	40.0	-0.105	0.02	1000.0	-1000.0	-0.007	-1000.0
Signaling events regulated by Ret tyrosine kinase	3.0	324.0	82.0	-0.218	0.074	1000.0	-1000.0	-0.034	-1000.0
EPHB forward signaling	3.0	262.0	85.0	-0.074	0.078	1000.0	-1000.0	-0.031	-1000.0
IL27-mediated signaling events	3.0	169.0	51.0	-0.115	0.021	1000.0	-1000.0	-0.027	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	3.0	271.0	74.0	-0.151	0.024	1000.0	-1000.0	-0.03	-1000.0
S1P3 pathway	3.0	159.0	42.0	-0.063	0.076	1000.0	-1000.0	-0.014	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	3.0	360.0	120.0	-0.086	0.107	1000.0	-1000.0	-0.031	-1000.0
ErbB2/ErbB3 signaling events	2.0	183.0	65.0	-0.008	0.049	1000.0	-1000.0	-0.024	-1000.0
Sphingosine 1-phosphate (S1P) pathway	2.0	71.0	28.0	-0.063	0.027	1000.0	-1000.0	-0.011	-1000.0
Osteopontin-mediated events	2.0	107.0	38.0	-0.008	0.034	1000.0	-1000.0	-0.012	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	2.0	143.0	54.0	-0.018	0.016	1000.0	-1000.0	-0.024	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	2.0	253.0	85.0	-0.018	0.022	1000.0	-1000.0	-0.023	-1000.0
Hedgehog signaling events mediated by Gli proteins	2.0	189.0	65.0	-0.033	0.032	1000.0	-1000.0	-0.023	-1000.0
p75(NTR)-mediated signaling	2.0	338.0	125.0	-0.006	0.032	1000.0	-1000.0	-0.035	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	2.0	204.0	83.0	-0.107	0.05	1000.0	-1000.0	-0.013	-1000.0
Signaling mediated by p38-gamma and p38-delta	2.0	36.0	15.0	-0.002	0.084	1000.0	-1000.0	-0.008	-1000.0
Regulation of p38-alpha and p38-beta	2.0	130.0	54.0	-0.101	0.042	1000.0	-1000.0	-0.029	-1000.0
Class I PI3K signaling events	2.0	166.0	73.0	-0.131	0.029	1000.0	-1000.0	-0.025	-1000.0
Regulation of Telomerase	2.0	244.0	102.0	-0.151	0.03	1000.0	-1000.0	-0.045	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	2.0	85.0	33.0	-0.084	0.03	1000.0	-1000.0	-0.019	-1000.0
p38 MAPK signaling pathway	2.0	97.0	44.0	-0.05	0.048	1000.0	-1000.0	-0.019	-1000.0
Caspase cascade in apoptosis	1.0	89.0	74.0	-0.168	0.027	1000.0	-1000.0	-0.019	-1000.0
Visual signal transduction: Cones	1.0	59.0	38.0	-0.003	0.02	1000.0	-1000.0	-0.007	-1000.0
JNK signaling in the CD4+ TCR pathway	1.0	31.0	17.0	-0.001	0.028	1000.0	-1000.0	-0.012	-1000.0
Insulin-mediated glucose transport	1.0	54.0	32.0	-0.023	0.022	1000.0	-1000.0	-0.013	-1000.0
IFN-gamma pathway	1.0	82.0	68.0	-0.055	0.075	1000.0	-1000.0	-0.031	-1000.0
Class I PI3K signaling events mediated by Akt	1.0	130.0	68.0	-0.051	0.026	1000.0	-1000.0	-0.013	-1000.0
Ephrin B reverse signaling	1.0	87.0	48.0	-0.04	0.025	1000.0	-1000.0	-0.015	-1000.0
TCR signaling in naïve CD8+ T cells	1.0	181.0	93.0	-0.019	0.028	1000.0	-1000.0	-0.032	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	1.0	49.0	45.0	-0.001	0.027	1000.0	-1000.0	-0.023	-1000.0
IL2 signaling events mediated by STAT5	1.0	34.0	22.0	-0.022	0.023	1000.0	-1000.0	-0.012	-1000.0
Arf6 trafficking events	1.0	132.0	71.0	-0.077	0.034	1000.0	-1000.0	-0.017	-1000.0
LPA4-mediated signaling events	0.0	2.0	12.0	0.0	0.015	1000.0	-1000.0	-0.009	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	8.0	23.0	0.001	0.027	1000.0	-1000.0	-0.008	-1000.0
Canonical NF-kappaB pathway	0.0	10.0	39.0	-0.0	0.031	1000.0	-1000.0	-0.022	-1000.0
Signaling events mediated by HDAC Class II	0.0	20.0	75.0	-0.017	0.05	1000.0	-1000.0	-0.012	-1000.0
BARD1 signaling events	0.0	0.0	57.0	-0.026	0.032	1000.0	-1000.0	-0.024	-1000.0
PLK2 and PLK4 events	0.0	0.0	3.0	0.009	0.011	1000.0	-1000.0	-0.003	-1000.0
a4b1 and a4b7 Integrin signaling	0.0	2.0	5.0	0.008	0.016	1000.0	-1000.0	-0.002	-1000.0
Aurora A signaling	0.0	0.0	60.0	-0.001	0.027	1000.0	-1000.0	-0.012	-1000.0
Aurora C signaling	0.0	2.0	7.0	0.0	0.019	1000.0	-1000.0	-0.005	-1000.0
PLK1 signaling events	0.0	4.0	85.0	-0.004	0.031	1000.0	-1000.0	-0.021	-1000.0
S1P5 pathway	0.0	1.0	17.0	-0.001	0.014	1000.0	-1000.0	-0.011	-1000.0
ceramide signaling pathway	0.0	18.0	49.0	0.0	0.023	1000.0	-1000.0	-0.015	-1000.0
Signaling events mediated by HDAC Class I	0.0	17.0	104.0	-0.021	0.03	1000.0	-1000.0	-0.025	-1000.0
TCGA08_p53	0.0	0.0	7.0	-0.001	0.011	1000.0	-1000.0	-0.002	-1000.0
Atypical NF-kappaB pathway	0.0	0.0	31.0	0.0	0.024	1000.0	-1000.0	-0.009	-1000.0
Glypican 2 network	0.0	0.0	4.0	0.01	0.016	1000.0	-1000.0	-0.002	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	0.0	14.0	125.0	-0.006	0.038	1000.0	-1000.0	-0.027	-1000.0
E-cadherin signaling in the nascent adherens junction	0.0	5.0	76.0	-0.0	0.027	1000.0	-1000.0	-0.034	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	0.0	27.0	-0.0	0.027	1000.0	-1000.0	-0.016	-1000.0
TCGA08_retinoblastoma	0.0	4.0	8.0	-0.007	0.011	1000.0	-1000.0	-0.003	-1000.0
VEGFR1 specific signals	0.0	0.0	56.0	0.0	0.037	1000.0	-1000.0	-0.014	-1000.0
Rapid glucocorticoid signaling	0.0	6.0	20.0	-0.0	0.014	1000.0	-1000.0	-0.005	-1000.0
Signaling events mediated by PRL	0.0	10.0	34.0	-0.004	0.025	1000.0	-1000.0	-0.016	-1000.0
Class IB PI3K non-lipid kinase events	0.0	0.0	3.0	-0.011	0.011	1000.0	-1000.0	-0.001	-1000.0
S1P4 pathway	0.0	4.0	25.0	-0.0	0.019	1000.0	-1000.0	-0.013	-1000.0
E-cadherin signaling events	0.0	0.0	5.0	0.007	0.019	1000.0	-1000.0	-0.001	-1000.0
Arf1 pathway	0.0	0.0	54.0	-0.0	0.022	1000.0	-1000.0	-0.01	-1000.0
Alternative NF-kappaB pathway	0.0	5.0	13.0	0.0	0.03	1000.0	-1000.0	-0.003	-1000.0
Aurora B signaling	0.0	39.0	67.0	-0.098	0.038	1000.0	-1000.0	-0.013	-1000.0
Total	1046	59640	7203	-16.78269859	5.74883335269	131000	-131000	-2.64071167384	-131000