rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(1), PGLYRP2(3) 890560 4 4 4 0 1 1 1 0 1 0 0.327 0.00219 0.823 2 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYC(1), RB1(2), SP1(2), SP3(3) 3297294 8 8 8 0 1 3 1 1 2 0 0.170 0.00267 0.823 3 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ3(2), COQ5(1), COQ7(1), NDUFA13(1) 1961734 5 5 5 0 0 2 0 2 1 0 0.269 0.00795 1.000 4 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 11 AKT1(3), GH1(1), GHR(2), IGF1R(2), SHC1(1), SOD3(1) 5269377 10 10 9 0 2 4 2 2 0 0 0.0698 0.00827 1.000 5 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(2), SDHA(1), SDHB(1), SDHC(2), UQCRC1(1) 3258606 7 7 7 0 1 2 0 1 3 0 0.189 0.0155 1.000 6 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(2), EGF(2), EGFR(4), TF(2) 6338332 10 10 10 1 4 2 1 3 0 0 0.266 0.0157 1.000 7 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(2), EGFR(4), ERBB3(2), UBE2D1(1) 5068951 9 9 9 1 3 0 1 4 1 0 0.296 0.0166 1.000 8 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 14 AKT1(3), EGFR(4), IGF1R(2), PRKCA(1), RB1(2), TEP1(4), TNKS(2), XRCC5(1) 13442481 19 19 18 1 6 4 3 6 0 0 0.0274 0.0189 1.000 9 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(3), ACAA2(1), ACAT1(1), EHHADH(5) 4121609 10 8 10 1 3 1 1 2 3 0 0.267 0.0198 1.000 10 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(1), EXT2(4), EXTL1(1), EXTL3(1), HS6ST1(1), HS6ST2(1), NDST2(2), NDST4(4) 10133977 15 15 15 1 1 7 0 5 2 0 0.0826 0.0220 1.000 11 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 NR1I3(2), PTGS1(2), PTGS2(2) 2640607 6 6 6 0 1 4 0 0 1 0 0.142 0.0257 1.000 12 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(2), ARHGEF1(2), GNA12(1), GNA13(1), MYLK(3), PLCB1(3), PRKCA(1), ROCK1(4) 10184546 17 17 16 2 3 4 2 6 2 0 0.223 0.0312 1.000 13 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 13 AKT1(3), BAD(1), GH1(1), GHR(2), NFKB1(2), RELA(2) 5857718 11 11 10 1 5 3 2 1 0 0 0.195 0.0321 1.000 14 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 6 SP1(2), SP3(3) 3069111 5 5 5 0 0 2 1 0 2 0 0.334 0.0479 1.000 15 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 NFKB1(2), PLCB1(3), PRKCA(1), RELA(2) 4046992 8 8 8 0 3 3 0 2 0 0 0.0984 0.0497 1.000 16 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 F13B(3), HSD17B4(1), HSD3B1(1), HSD3B2(1) 3991688 6 6 6 0 0 0 1 2 3 0 0.284 0.0516 1.000 17 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOC(2), GPI(1), PFKL(2), PFKM(2), PFKP(2), PGM3(1), PRPS1L1(3), RBKS(1), RPE(1), TKT(1) 11958051 16 16 16 2 2 3 1 6 4 0 0.189 0.0525 1.000 18 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 DCN(1), KERA(2) 1770834 3 3 3 1 0 0 2 0 1 0 0.888 0.0561 1.000 19 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 CHAT(2), DBH(2), DDC(1), GAD1(1), GAD2(3), HDC(1), MAOA(1), TPH1(1) 7059830 12 12 12 2 1 3 1 4 3 0 0.414 0.0668 1.000 20 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT1(1), EHHADH(5), SDHB(1) 3844398 7 6 7 1 2 2 1 0 2 0 0.483 0.0775 1.000 21 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOC(2), GPI(1), PFKM(2), PFKP(2), PGM3(1), PRPS1L1(3), RBKS(1), RPE(1), TKT(1) 10059450 14 14 14 2 2 3 1 6 2 0 0.269 0.0802 1.000 22 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 ALDOC(2), GCK(1), GMPPB(1), HK2(1), HK3(1), PFKFB1(1), PFKFB4(1), PFKM(2), PFKP(2), PMM1(1), TPI1(1) 11701759 14 14 14 1 2 2 2 5 3 0 0.0996 0.0853 1.000 23 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 DHRS1(1), DHRS7(1), DHRSX(1), PON1(1), PON2(2), PON3(1) 4430596 7 7 7 0 1 1 1 4 0 0 0.176 0.0881 1.000 24 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX15(2), ALOX5AP(1), LTC4S(1), PLA2G2A(1), PTGS1(2), PTGS2(2), TBXAS1(1) 7370397 10 10 10 0 2 5 2 0 1 0 0.0430 0.103 1.000 25 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT1(1), HMGCL(2) 1673620 3 3 3 1 0 1 1 0 1 0 0.807 0.105 1.000 26 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(1), ALDH1A2(2) 1923120 3 3 3 0 0 2 1 0 0 0 0.453 0.105 1.000 27 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(3), IL4R(3), IRS1(2), JAK1(2), JAK3(2), SHC1(1) 7238601 13 12 12 2 1 3 3 3 3 0 0.362 0.110 1.000 28 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 EHHADH(5) 2376418 5 4 5 0 2 1 0 0 2 0 0.325 0.118 1.000 29 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(2) 1000074 2 2 2 1 0 1 0 1 0 0 0.867 0.118 1.000 30 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(1), ATIC(3), DHFR(1), FTCD(1), GART(1), MTHFD1(1), MTHFD1L(1), MTHFR(2), MTR(1), SHMT2(1), TYMS(1) 9340808 14 14 14 2 2 7 0 1 4 0 0.240 0.125 1.000 31 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 18 ADCY1(1), ARHGEF1(2), F2(1), F2R(1), GNA12(1), GNA13(1), MAP3K7(1), PLCB1(3), PRKCA(1), ROCK1(4) 11614208 16 16 15 2 4 3 1 5 3 0 0.243 0.138 1.000 32 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(3), BAD(1), BTK(1), EEA1(2), LYN(1), PFKL(2), PFKM(2), PFKP(2), RAC1(1), VAV2(2) 12314219 17 15 16 3 4 6 2 2 3 0 0.214 0.140 1.000 33 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDOC(2), TPI1(1) 1924683 3 3 3 1 1 0 1 1 0 0 0.784 0.140 1.000 34 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CSF1R(2), EGF(2), EGFR(4), MET(3), PRKCA(1), SH3GLB2(1) 9567310 13 12 13 2 4 0 1 8 0 0 0.295 0.141 1.000 35 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 GAD1(1), GAD2(3) 2829624 4 4 4 1 0 1 1 1 1 0 0.776 0.141 1.000 36 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 10 AKT1(3), KLK2(1), NTRK1(1), PRKCA(1), SHC1(1) 6380810 7 7 6 1 0 3 1 1 2 0 0.565 0.144 1.000 37 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 MTMR2(1), MTMR6(1), THTPA(2) 3152669 4 4 4 1 0 2 0 2 0 0 0.684 0.157 1.000 38 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 ALDOC(2), GMPPB(1), HK2(1), HK3(1), MTMR2(1), MTMR6(1), PFKFB1(1), PFKFB4(1), PFKL(2), PFKM(2), PFKP(2), PGM2(1), PMM1(1), TPI1(1), TSTA3(1) 18186292 19 18 19 2 3 3 2 7 4 0 0.0959 0.158 1.000 39 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CYP11B2(1), HSD11B1(1), HSD3B1(1), HSD3B2(1) 3402096 4 4 4 0 0 0 0 1 3 0 0.314 0.165 1.000 40 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(2), GAD1(1), HDC(1), TPH1(1) 2967303 5 5 5 0 1 1 0 3 0 0 0.274 0.165 1.000 41 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 15 AKT1(3), NFKB1(2), RB1(2), RELA(2), SP1(2) 8469116 11 10 10 1 3 4 1 2 1 0 0.197 0.169 1.000 42 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(1), ATIC(3), DHFR(1), GART(1), MTHFD1(1), MTHFD1L(1), MTHFR(2), MTR(1), SHMT2(1), TYMS(1) 8836757 13 13 13 2 2 7 0 1 3 0 0.263 0.173 1.000 43 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), EHHADH(5) 5971516 10 8 10 2 3 3 1 1 2 0 0.468 0.176 1.000 44 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 PARK2(1), SNCAIP(2), UBE2L3(1) 3171568 4 4 4 0 0 1 3 0 0 0 0.495 0.183 1.000 45 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(2), ENPP1(2), ENPP3(1), NMNAT1(1), NNT(3), NT5E(1) 7164398 10 9 10 1 3 2 0 3 2 0 0.240 0.190 1.000 46 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 EPN1(1), EPS15(2), NME1(1), PICALM(1), PPP3CA(1), PPP3CC(1), SYNJ1(1), SYNJ2(2), SYT1(1) 10691275 11 11 11 1 1 1 1 6 2 0 0.238 0.192 1.000 47 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 AOC2(2), CES1(3) 2955227 5 4 5 1 3 0 2 0 0 0 0.496 0.194 1.000 48 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 19 AKT1(3), BAD(1), NFKB1(2), RAC1(1), RALGDS(1), RELA(2) 8019766 10 10 9 1 3 4 1 2 0 0 0.204 0.205 1.000 49 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(1), AASDH(1), AASDHPPT(1), AASS(1) 3429471 4 4 4 1 1 0 0 3 0 0 0.667 0.211 1.000 50 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 CFL1(1), CFLAR(1) 1909680 2 2 2 0 0 1 0 0 1 0 0.730 0.213 1.000 51 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), IL4R(3), JAK1(2), TYK2(1) 5175873 7 6 7 0 0 0 1 3 3 0 0.231 0.215 1.000 52 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), IL4R(3), JAK1(2), TYK2(1) 5175873 7 6 7 0 0 0 1 3 3 0 0.231 0.215 1.000 53 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ACADSB(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), AOC2(2), CNDP1(1), DPYD(4), EHHADH(5), GAD1(1), GAD2(3) 14310081 22 19 22 3 6 6 2 4 4 0 0.151 0.222 1.000 54 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 SEC61A2(1), SRP19(1), SRP54(2), SRPR(2) 3727610 6 5 5 0 3 1 0 1 1 0 0.243 0.224 1.000 55 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 23 BMPR1B(1), EGR1(1), INHA(1), LHCGR(1), MSH5(1), NCOR1(6), NRIP1(2), PGR(2), PRLR(2) 13983968 17 16 17 2 2 3 0 4 8 0 0.204 0.226 1.000 56 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(1), AASDHPPT(1), AASS(1) 2320434 3 3 3 1 1 0 0 2 0 0 0.765 0.230 1.000 57 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 EPX(1), MPO(1), MTHFR(2), SHMT2(1), TPO(1) 5715637 6 6 6 1 0 4 1 0 1 0 0.365 0.237 1.000 58 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(2), CYR61(1), EIF4E(1), NR4A3(1) 5296783 5 5 5 0 0 2 0 3 0 0 0.282 0.240 1.000 59 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(1) 356311 1 1 1 0 1 0 0 0 0 0 0.739 0.244 1.000 60 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ENO1(2), GPI(1), PFKL(2), PGK1(1), TPI1(1) 4547116 7 6 7 2 3 0 0 0 4 0 0.522 0.245 1.000 61 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(1), CS(2), PC(1), SLC25A11(1) 4544204 5 5 5 0 1 0 1 2 1 0 0.253 0.246 1.000 62 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 CS(2), PC(1), PDHX(1), PDK1(1), PDK2(1), PDK3(1), PDK4(1), PDP2(1), SDHA(1), SDHB(1), SDHC(2), SUCLG1(1) 13936051 14 13 14 1 1 4 2 3 4 0 0.140 0.249 1.000 63 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 21 ADCY1(1), AKT1(3), ITGAV(1), PLCB1(3), PRKCA(1), RAC1(1), SMPD2(2) 12437429 12 12 11 1 2 6 1 3 0 0 0.144 0.250 1.000 64 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT1(1), ACOT11(1), DHRS1(1), DHRS7(1), DHRSX(1), EHHADH(5), ESCO1(4), ESCO2(1) 12795882 15 13 15 1 6 3 1 1 4 0 0.108 0.250 1.000 65 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP1(1), ACPT(1), ENPP1(2), ENPP3(1), RFK(1) 4786437 6 6 6 0 2 0 0 2 2 0 0.198 0.258 1.000 66 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 CYP11B2(1), CYP21A2(1), HSD11B1(1), HSD3B1(1), HSD3B2(1) 4535581 5 5 5 0 1 0 0 1 3 0 0.229 0.260 1.000 67 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 CYP11B2(1), CYP21A2(1), HSD11B1(1), HSD3B1(1), HSD3B2(1) 4535581 5 5 5 0 1 0 0 1 3 0 0.229 0.260 1.000 68 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 BPNT1(1), PAPSS2(1), SULT1E1(1), SUOX(1) 3013654 4 4 4 0 1 1 0 1 1 0 0.342 0.265 1.000 69 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 EHHADH(5), HSD17B4(1), SIRT1(1) 5819258 7 6 7 1 2 1 0 1 3 0 0.495 0.276 1.000 70 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 16 ADRB2(1), AKT1(3), NFKB1(2), NOS3(2), RELA(2), SYT1(1) 7672404 11 10 10 2 4 4 2 1 0 0 0.375 0.285 1.000 71 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 19 AKT1(3), NFKB1(2), RAC1(1), RB1(2), RELA(2), TFDP1(1) 8446614 11 9 10 1 3 3 1 4 0 0 0.171 0.287 1.000 72 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP1(1), ACPT(1), ENPP1(2), ENPP3(1), MTMR2(1), MTMR6(1), RFK(1) 7416865 8 8 8 1 2 1 0 3 2 0 0.349 0.292 1.000 73 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(1), IL12A(1) 1477864 2 2 2 1 0 1 0 0 1 0 0.866 0.304 1.000 74 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMPR1A(1), BMPR1B(1), BMPR2(1) 3078847 3 3 3 0 0 1 0 1 1 0 0.591 0.313 1.000 75 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 NFATC2(1), NFATC4(1), PPP3CA(1), PPP3CC(1), PRKCA(1), SP1(2), SP3(3), SYT1(1) 10328225 11 10 11 1 3 2 2 2 2 0 0.199 0.316 1.000 76 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 DPYD(4), ENPP1(2), ENPP3(1), PANK1(1) 6866362 8 8 8 1 4 1 0 2 1 0 0.321 0.325 1.000 77 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 DAG1(2), ITPKB(1) 2975533 3 3 3 0 0 2 1 0 0 0 0.415 0.326 1.000 78 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNB1(1), IL12A(1), IL16(2), IL9(1), LTA(1) 4910173 6 6 6 1 1 1 0 2 2 0 0.557 0.329 1.000 79 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 ARSB(2), ARSD(1), ARSE(1), CYP11B2(1), HSD11B1(1), HSD3B1(1), HSD3B2(1), STS(1), SULT1E1(1), UGT1A1(2), UGT1A3(1), UGT1A7(1), UGT2B15(3) 13416124 17 14 17 3 4 2 0 6 5 0 0.244 0.332 1.000 80 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 13 AKT1(3), BAD(1), IGF1R(2), IRS1(2), SHC1(1) 8070436 9 8 8 1 1 3 1 3 1 0 0.327 0.336 1.000 81 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 20 AKT1(3), EIF4E(1), EIF4G1(3), GHR(2), IRS1(2), PDK2(1), PRKCA(1) 12394804 13 12 12 0 3 3 1 4 2 0 0.0531 0.337 1.000 82 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 11 CREBBP(2), DAXX(1), PAX3(1), RB1(2), SIRT1(1), SP100(1) 8738884 8 8 8 1 2 0 1 5 0 0 0.389 0.351 1.000 83 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(1), BAD(1), BCL2L11(1), CES1(3) 5284666 6 6 6 0 2 1 2 1 0 0 0.245 0.358 1.000 84 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(1), ACOX3(1), FADS2(1), PLA2G2A(1), PLA2G4A(1) 4976179 5 5 5 1 1 1 1 1 1 0 0.587 0.360 1.000 85 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS1(1), DHRS7(1), DHRSX(1), ESCO1(4), ESCO2(1) 8169443 8 8 8 0 3 2 0 1 2 0 0.137 0.363 1.000 86 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIPT1(1) 756907 1 1 1 0 0 1 0 0 0 0 0.809 0.370 1.000 87 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 17 AKT1(3), EIF4E(1), IGF1R(2), INPPL1(1), PDK2(1) 8208908 8 8 7 1 1 2 1 4 0 0 0.385 0.371 1.000 88 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 BPNT1(1), CHST12(1), PAPSS2(1), SULT1E1(1), SUOX(1) 4539998 5 5 5 0 1 1 0 2 1 0 0.279 0.376 1.000 89 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 NFKB1(2), RELA(2), TNFRSF13B(2), TRAF2(1) 7128577 7 7 7 1 4 2 0 1 0 0 0.363 0.388 1.000 90 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 B2M(1), CD74(1), CD8A(1), CD8B(1), CIITA(1), HLA-DMB(1), HLA-DQA2(1), HLA-G(1), HSP90AA1(2), HSP90AB1(1), HSPA5(2), IFI30(1), IFNA10(1), IFNA13(1), IFNA16(2), IFNA17(1), IFNA21(1), IFNA6(1), KIR3DL1(2), LTA(1), NFYC(1), PSME2(1), RFXAP(1) 22782062 27 22 27 4 7 5 2 4 9 0 0.159 0.401 1.000 91 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), XYLT1(2) 3179774 3 3 3 1 0 1 1 0 1 0 0.881 0.405 1.000 92 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), XYLT1(2) 3179774 3 3 3 1 0 1 1 0 1 0 0.881 0.405 1.000 93 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOC(2), GOT2(1), GPT(1), ME3(1), PGK1(1), PGK2(1), RPE(1), TKT(1), TPI1(1) 9913368 10 10 10 0 3 1 1 4 1 0 0.0519 0.405 1.000 94 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAD(1), MAP2K4(2), NFKB1(2), NSMAF(2), RELA(2), TRAF2(1) 10064369 10 10 10 0 4 4 0 2 0 0 0.0505 0.413 1.000 95 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 14 NFKB1(2), PLCB1(3), PRKCA(1), RELA(2) 7434304 8 8 8 1 3 3 0 2 0 0 0.249 0.413 1.000 96 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR3(1), ARHGAP5(2), ARHGAP6(1), ARHGEF1(2), ARHGEF11(2), ARHGEF5(2), ARPC4(1), CFL1(1), LIMK1(1), MYLK(3), PFN1(1), PIP5K1A(1), ROCK1(4), TLN1(2) 22138347 24 22 23 3 3 5 3 5 8 0 0.191 0.419 1.000 97 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOC(2), GOT2(1), GPT(1), ME3(1), PGK1(1), RPE(1), TKT(1), TPI1(1) 8860419 9 9 9 0 3 1 1 3 1 0 0.0678 0.425 1.000 98 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(2), ENPP1(2), ENPP3(1), NADK(2), NMNAT1(1), NNT(3), NT5E(1), NUDT12(2) 10609429 14 10 14 2 4 3 0 3 4 0 0.277 0.426 1.000 99 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT2(1) 1286413 1 1 1 0 0 1 0 0 0 0 0.726 0.427 1.000 100 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 29 ANPEP(1), GSTA2(2), GSTA3(1), GSTM2(1), GSTM3(1), GSTO2(1) 8468871 7 7 7 1 1 2 1 3 0 0 0.410 0.431 1.000 101 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 18 AKT1(3), APAF1(1), BAD(1), PRKCA(1), STAT1(1), TLN1(2) 10022914 9 9 8 1 1 3 2 2 1 0 0.297 0.436 1.000 102 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(2), FUCA2(1), HEXB(2), LCT(1), MAN2B1(2), MAN2B2(1), MAN2C1(1), NEU4(1) 10030126 11 10 11 2 2 5 0 2 2 0 0.338 0.438 1.000 103 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 CA12(1), CA14(1), CA2(2), CA3(1), CA5A(1), CA6(1), CA8(1), CA9(1), CPS1(2), GLUL(1), HAL(1) 9362483 13 13 13 3 1 5 1 3 3 0 0.456 0.438 1.000 104 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNB1(1), JAK1(2), STAT1(1), STAT2(1), TYK2(1) 5342351 6 5 6 1 1 0 0 2 3 0 0.641 0.440 1.000 105 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ERBB4(2), NRG2(1), PRKCA(1) 4442513 4 4 4 1 1 1 0 2 0 0 0.707 0.441 1.000 106 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 14 ABL1(1), POLR1A(2), POLR1B(1), POLR1C(1), RAC1(1), RB1(2) 8535365 8 8 8 0 3 0 1 4 0 0 0.126 0.453 1.000 107 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1) 3924876 5 4 5 2 1 2 1 1 0 0 0.776 0.454 1.000 108 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1) 3924876 5 4 5 2 1 2 1 1 0 0 0.776 0.454 1.000 109 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 TPI1(1) 810274 1 1 1 1 1 0 0 0 0 0 0.925 0.459 1.000 110 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(2), GNA12(1), PRKAG1(2) 4968569 5 5 5 0 2 0 1 2 0 0 0.286 0.466 1.000 111 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(1), GOT2(1) 2308555 2 2 2 1 0 1 0 0 1 0 0.792 0.466 1.000 112 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(1), PLCB1(3) 3532231 4 4 4 1 2 2 0 0 0 0 0.593 0.470 1.000 113 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(1), CS(2), HAO1(1), MTHFD1(1), MTHFD1L(1) 6313639 6 6 6 0 1 3 0 2 0 0 0.176 0.472 1.000 114 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(1), HSD17B4(1), MECR(1) 4159674 3 3 3 1 0 1 0 1 1 0 0.760 0.473 1.000 115 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 6 AKT1(3), PLCB1(3), PRKCA(1) 5245247 7 7 6 2 1 4 1 1 0 0 0.674 0.479 1.000 116 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 ALOX15(2), CYP4F2(1), CYP4F3(1), EPX(1), MPO(1), PLA2G2A(1), PLA2G4A(1), PTGS1(2), PTGS2(2), TBXAS1(1), TPO(1) 13686542 14 14 14 2 2 7 4 0 1 0 0.171 0.479 1.000 117 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 ALOX12B(1), ALOX15(2), CYP2B6(2), CYP2C19(2), CYP2C8(2), CYP2J2(1), CYP4F2(1), CYP4F3(1), LTC4S(1), PLA2G2A(1), PLA2G4A(1), PTGS1(2), PTGS2(2), TBXAS1(1) 19112755 20 20 20 3 2 7 4 4 3 0 0.179 0.480 1.000 118 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 8 MMP2(1), MMP9(2) 3472773 3 3 3 1 2 0 1 0 0 0 0.713 0.482 1.000 119 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 KEAP1(2), PRKCA(1) 4348277 3 3 3 1 1 1 0 1 0 0 0.706 0.484 1.000 120 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 IFNB1(1), NFKB1(2), RELA(2) 5442661 5 5 5 0 2 1 0 1 1 0 0.302 0.485 1.000 121 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BIRC2(1), CFLAR(1), MAP2K4(2), MAP3K3(1), MAP3K7(1), NFKB1(2), NFKBIB(1), TNFAIP3(1), TRAF2(1) 13364486 11 11 11 1 3 4 1 1 2 0 0.183 0.485 1.000 122 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ALDH1A3(1), ALDH1B1(1), AOC2(2), CNDP1(1), DPYD(4), EHHADH(5), GAD1(1), GAD2(3) 13288318 18 16 18 3 6 4 1 4 3 0 0.267 0.488 1.000 123 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(2), EGFR(4) 8453084 6 6 6 0 2 0 1 3 0 0 0.225 0.500 1.000 124 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCR1(1), CCR2(3), CCR4(1), IL12A(1), IL12RB2(1), IL4R(3) 9785701 10 9 10 1 3 2 2 1 2 0 0.184 0.501 1.000 125 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 15 AKT1(3), MEF2C(1), NTRK1(1), SHC1(1) 8008779 6 6 5 1 0 3 1 1 1 0 0.532 0.503 1.000 126 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 32 AKT1(3), APC(2), CCL15(1), DAG1(2), EGFR(4), ITPKB(1), ITPR1(1), ITPR2(5), MAPK10(1), PIK3CD(2) 24362937 22 21 21 3 5 6 3 3 5 0 0.147 0.509 1.000 127 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 63 AGPAT2(1), AGPAT3(1), AGPAT4(1), CDS1(1), CHAT(2), DGKD(3), DGKI(4), DGKQ(1), DGKZ(1), ESCO1(4), ESCO2(1), GNPAT(1), GPD1(1), PLA2G2A(1), PLA2G4A(1), PLD1(2), PPAP2A(1), PTDSS1(1) 32036902 28 26 28 2 2 7 5 4 10 0 0.0307 0.509 1.000 128 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(1), CS(2), HAO1(1), MTHFD1(1), MTHFD1L(1) 6610809 6 6 6 0 1 3 0 2 0 0 0.175 0.516 1.000 129 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(1), HDAC9(1), MEF2C(1) 3749643 3 3 3 1 0 0 1 2 0 0 0.814 0.518 1.000 130 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(1), PSMA2(1), PSMA6(1) 4314925 3 3 3 0 1 2 0 0 0 0 0.397 0.532 1.000 131 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(1), MPO(1), TPO(1) 4100566 3 3 3 0 0 2 1 0 0 0 0.410 0.536 1.000 132 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(1), PRKCA(1) 2416383 2 2 2 0 0 0 0 1 1 0 0.864 0.536 1.000 133 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(2), AGTR1(1), NOS3(2) 4801110 5 5 5 0 2 2 0 1 0 0 0.179 0.544 1.000 134 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F2(1), F2R(1), F3(1), F5(4), FGA(4), FGB(1), PROC(1), PROS1(2) 8083283 15 15 15 4 4 3 3 4 1 0 0.641 0.547 1.000 135 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH4(1), ADHFE1(1) 2789302 2 2 2 0 0 1 0 1 0 0 0.581 0.547 1.000 136 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CDC34(1), RB1(2), TFDP1(1) 4071151 4 4 4 0 2 0 0 2 0 0 0.348 0.556 1.000 137 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 8 NFKB1(2), RELA(2) 4381757 4 4 4 1 2 1 0 1 0 0 0.652 0.558 1.000 138 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 CRY1(1), NPAS2(1), PER1(2), PER2(1), PER3(3) 8400979 8 7 8 1 3 4 0 0 1 0 0.270 0.560 1.000 139 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(2), JAK3(2), STAT3(3), TYK2(1) 5764681 8 7 8 2 2 0 1 3 2 0 0.696 0.560 1.000 140 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(2), MAP2(4), PPP1CA(1), PRKAG1(2) 8969268 9 9 9 2 1 1 1 5 1 0 0.562 0.561 1.000 141 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA3(2) 2942673 2 2 2 0 0 1 1 0 0 0 0.518 0.563 1.000 142 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA2(1), ANXA4(1), ANXA6(2), HSD11B1(1), PLA2G4A(1), PTGS1(2), PTGS2(2), SCGB1A1(1), TBXAS1(1) 10203130 12 12 12 3 1 3 3 2 3 0 0.541 0.570 1.000 143 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNB1(1), JAK1(2), STAT1(1), STAT2(1), TYK2(1) 6160881 6 5 6 1 1 0 0 2 3 0 0.639 0.573 1.000 144 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 CNR1(1), DNMT1(3), MTNR1B(1), PTAFR(1) 5497433 6 5 6 0 3 3 0 0 0 0 0.0818 0.578 1.000 145 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CDC34(1), RB1(2), TFDP1(1) 4203209 4 4 4 1 2 0 0 2 0 0 0.674 0.583 1.000 146 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 EPX(1), MPO(1), SHMT2(1), TPO(1) 5804252 4 4 4 1 0 2 1 0 1 0 0.574 0.587 1.000 147 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(1), PPARG(1) 2860956 2 2 2 0 0 0 0 1 1 0 0.582 0.589 1.000 148 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(1), GPR171(1), GPR75(1) 4836125 3 3 3 0 0 1 1 1 0 0 0.462 0.590 1.000 149 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(2), GALNS(1), HEXB(2), LCT(1), NAGLU(1) 7021415 7 6 7 1 2 3 0 1 1 0 0.402 0.591 1.000 150 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(2), FUCA2(1), HEXB(2), LCT(1), MAN2C1(1), NEU4(1) 8137119 8 7 8 2 2 2 0 2 2 0 0.583 0.592 1.000 151 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 HEMK1(1), METTL6(1), PRMT3(2), PRMT5(2) 6884541 6 6 6 4 0 1 0 1 4 0 0.942 0.594 1.000 152 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 11 RB1(2), TFDP1(1) 4022064 3 3 3 0 1 0 0 2 0 0 0.476 0.598 1.000 153 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 17 AKT1(3), HSPA1A(1), NFKBIB(1) 6732387 5 5 4 0 1 3 1 0 0 0 0.252 0.600 1.000 154 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 ACAT1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), EHHADH(5), GAD1(1), GAD2(3), HMGCL(2), SDHB(1) 12697651 18 15 18 4 3 6 3 2 4 0 0.463 0.601 1.000 155 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 DUSP1(1), IKBKAP(1), LTA(1), NFKB1(2), RELA(2), TANK(1), TNFAIP3(1), TRAF2(1) 11017878 10 9 10 1 4 3 0 2 1 0 0.198 0.611 1.000 156 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(1), HK2(1), HK3(1), PGM3(1) 5032384 4 4 4 0 1 0 1 1 1 0 0.383 0.611 1.000 157 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOC(2), ENO1(2), GCK(1), GOT2(1), GPI(1), HK2(1), HK3(1), PC(1), PDHX(1), PFKL(2), PFKM(2), PFKP(2), PGK1(1), PGK2(1), TPI1(1) 20892986 20 19 20 3 4 4 3 3 6 0 0.130 0.618 1.000 158 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 ITGAL(2), ITGAM(1), ITGB2(1), SELE(2) 5080535 6 6 6 2 2 3 0 1 0 0 0.648 0.618 1.000 159 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(2), GOT2(1) 4087765 3 3 3 0 1 1 0 0 1 0 0.400 0.621 1.000 160 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARFGEF2(1), COPA(3), GBF1(2), KDELR3(1) 8006623 7 6 7 1 2 2 1 1 1 0 0.398 0.623 1.000 161 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 26 ACLY(1), ACO1(1), CS(2), PC(1), PCK2(1), SDHA(1), SDHB(1), SDHC(2), SUCLG1(1) 14265388 11 10 11 1 2 1 1 3 4 0 0.200 0.624 1.000 162 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(1), MPO(1), TPO(1) 4737717 3 3 3 0 0 2 1 0 0 0 0.418 0.632 1.000 163 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 GCK(1), HEXB(2), HK2(1), HK3(1), PGM3(1) 8323629 6 6 6 1 1 1 1 1 2 0 0.572 0.637 1.000 164 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 RPE(1), UGT1A1(2), UGT1A3(1), UGT1A7(1), UGT2A3(1), UGT2B11(2), UGT2B15(3), UGT2B28(1), UGT2B7(1) 13456900 13 10 13 2 5 1 2 4 1 0 0.279 0.638 1.000 165 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 DRD2(1), GRM1(4), PLCB1(3), PPP1CA(1), PPP3CA(1) 7901111 10 10 10 3 3 5 0 2 0 0 0.533 0.642 1.000 166 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 ALOX15(2), CYP2C19(2), CYP2C8(2), CYP2J2(1), CYP3A43(2), PLA2G2A(1), PLA2G4A(1) 11774026 11 11 11 2 2 2 2 2 3 0 0.417 0.642 1.000 167 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(1), AOC2(2), CES1(3), DDHD1(2), ESCO1(4), ESCO2(1) 12446979 13 11 13 2 5 1 3 2 2 0 0.348 0.643 1.000 168 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 CRY1(1), PER1(2) 4169325 3 3 3 1 2 1 0 0 0 0 0.730 0.644 1.000 169 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACAA1(3), ACOX1(1), ACOX3(1), FADS2(1), FASN(1), PECR(1) 6974104 8 7 8 2 3 0 2 2 1 0 0.549 0.644 1.000 170 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 GRIN1(1), NFKB1(2), RELA(2) 6231374 5 5 5 1 2 1 0 2 0 0 0.549 0.648 1.000 171 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 35 ANPEP(1), GSTA2(2), GSTA3(1), GSTM2(1), GSTM3(1), GSTO2(1) 10410292 7 7 7 1 1 2 1 3 0 0 0.404 0.649 1.000 172 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 NFKB1(2), RELA(2) 4850208 4 4 4 1 2 1 0 1 0 0 0.580 0.657 1.000 173 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 13 AKT1(3), PDK2(1), SHC1(1) 7808023 5 5 4 1 0 3 1 1 0 0 0.579 0.657 1.000 174 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 DHRS1(1), DHRS7(1), DHRSX(1), HEMK1(1), METTL6(1), PRMT3(2), PRMT5(2) 7390907 9 9 9 4 1 2 0 2 4 0 0.811 0.657 1.000 175 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 13 AKT1(3), NTRK1(1), PIK3CD(2), SHC1(1) 6602866 7 7 6 2 0 4 1 0 2 0 0.619 0.658 1.000 176 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(1), PSMA2(1), PSMA6(1), PSMD2(1), PSMD6(1) 7904895 5 5 5 0 1 3 0 1 0 0 0.243 0.659 1.000 177 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(2), DYRK1B(1), GLI2(2), GLI3(2), SHH(1) 8191454 8 8 8 2 0 5 0 3 0 0 0.533 0.662 1.000 178 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 PDE1B(1), PLCB1(3) 5473864 4 4 4 0 1 2 0 1 0 0 0.297 0.665 1.000 179 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 12 AKT1(3), BAD(1), MUSK(1) 6907192 5 5 4 0 1 2 2 0 0 0 0.233 0.669 1.000 180 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 SHMT2(1) 2044131 1 1 1 1 0 0 0 0 1 0 0.893 0.670 1.000 181 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ADH4(1), ADHFE1(1), DHRS1(1), DHRS7(1), DHRSX(1), ESCO1(4), ESCO2(1) 12303315 10 9 10 0 3 3 0 2 2 0 0.0786 0.670 1.000 182 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 19 AKT1(3), EIF4E(1), EIF4G1(3), PDK2(1), TSC2(1) 12123920 9 9 8 0 1 4 1 2 1 0 0.119 0.672 1.000 183 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 10 ACLY(1), ACO1(1), ACSS1(2), ACSS2(1) 6119225 5 5 5 0 3 1 0 0 1 0 0.174 0.677 1.000 184 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 DUSP1(1), IKBKAP(1), NFKB1(2), RELA(2), TNFAIP3(1) 8896606 7 7 7 1 2 3 0 1 1 0 0.389 0.678 1.000 185 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAS1(1), ALAS2(1), HMBS(1) 3667461 3 3 3 1 2 0 1 0 0 0 0.745 0.681 1.000 186 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP1(1), ACPT(1), ALPP(2), CYP3A43(2), DHRS1(1), DHRS7(1), DHRSX(1), PON1(1), PON2(2), PON3(1) 8883597 13 13 13 4 2 3 2 5 1 0 0.586 0.683 1.000 187 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(1), EIF4E(1), FBL(1), GPT(1) 4405972 4 3 4 1 2 1 0 1 0 0 0.644 0.683 1.000 188 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 B4GALT2(1), GAA(1), GANAB(1), GCK(1), HK2(1), HK3(1), LCT(1), MGAM(2), PFKM(2), PFKP(2), PGM3(1) 15953445 14 11 14 2 3 3 2 3 3 0 0.245 0.685 1.000 189 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 28 EGFR(4), IGF1R(2), KLK2(1), PTPRR(1), RPS6KA5(2), SHC1(1), STAT3(3) 16008932 14 14 14 2 4 1 1 7 1 0 0.319 0.687 1.000 190 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 LDLR(1), NR1H3(1) 2687096 2 2 2 1 1 1 0 0 0 0 0.837 0.691 1.000 191 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 BCHE(2), CES1(3), UGT1A1(2), UGT1A3(1), UGT1A7(1) 11270070 9 8 9 1 3 1 2 1 2 0 0.278 0.691 1.000 192 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAS1(1), ALAS2(1), HBB(1), HMBS(1) 3750172 4 3 4 1 3 0 1 0 0 0 0.620 0.699 1.000 193 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(1), AGTR1(1), CMA1(1), COL4A1(1), COL4A2(2), COL4A4(2) 12275962 8 8 8 1 1 3 0 2 2 0 0.420 0.700 1.000 194 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLUD2(1) 2244243 1 1 1 0 0 1 0 0 0 0 0.751 0.709 1.000 195 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(1), GOT2(1) 3380751 2 2 2 0 0 2 0 0 0 0 0.558 0.711 1.000 196 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(1), HK2(1), HK3(1), PGM3(1) 5730797 4 4 4 0 1 0 1 1 1 0 0.379 0.712 1.000 197 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(1), IL22(1), JAK1(2), JAK3(2), STAT1(1), STAT3(3), STAT5A(1), STAT5B(1), TYK2(1) 9028839 13 11 13 3 3 2 1 5 2 0 0.540 0.713 1.000 198 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(1) 1603764 1 1 1 0 1 0 0 0 0 0 0.657 0.722 1.000 199 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 EHHADH(5), PECR(1), SLC25A20(1) 8296025 7 6 7 1 3 1 0 1 2 0 0.473 0.727 1.000 200 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(2) 2395489 2 2 2 2 0 0 0 1 1 0 0.978 0.734 1.000 201 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(1), MARS(1), MARS2(1), PAPSS2(1), SEPHS1(1) 6086327 5 4 5 1 2 2 0 1 0 0 0.466 0.737 1.000 202 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 CHAT(2) 3413045 2 2 2 0 0 1 0 1 0 0 0.575 0.738 1.000 203 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 IL5RA(1) 2634034 1 1 1 1 0 0 1 0 0 0 0.970 0.740 1.000 204 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 20 F2(1), F2R(1), ITGA1(1), PLA2G4A(1), PLCB1(3), PRKCA(1), PTGS1(2), SYK(2), TBXAS1(1) 11792545 13 13 13 3 2 7 1 2 1 0 0.418 0.743 1.000 205 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 15 ADAM12(3), EGF(2), EGFR(4), NFKB1(2), PRKCA(1), RELA(2) 9896749 14 13 14 4 6 2 1 5 0 0 0.529 0.744 1.000 206 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS(1), GOT2(1), SULT4A1(2) 6182458 4 4 4 1 1 2 0 1 0 0 0.621 0.748 1.000 207 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNH(1), SHH(1) 4282988 2 2 2 1 0 0 0 2 0 0 0.883 0.749 1.000 208 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 AGA(2), ARSB(2), FUCA2(1), GALNS(1), HEXB(2), LCT(1), MAN2B1(2), MAN2B2(1), MAN2C1(1), NAGLU(1), NEU4(1), SPAM1(1) 16877655 16 15 16 3 3 7 1 3 2 0 0.290 0.750 1.000 209 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 CS(2), SDHA(1) 4633120 3 3 3 0 1 0 0 2 0 0 0.449 0.750 1.000 210 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 DHFR(1), POLG(1), RRM1(3) 6142170 5 4 5 0 2 1 0 0 2 0 0.309 0.752 1.000 211 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(1), LEPR(1), PRKAA2(2), PRKAG1(2), PRKAG2(1) 7150176 7 7 7 2 1 0 1 5 0 0 0.697 0.755 1.000 212 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT1(1), HMGCL(2), HMGCS1(2) 3544528 5 5 5 2 0 1 1 1 2 0 0.768 0.757 1.000 213 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 GRIA2(1) 1841514 1 1 1 1 1 0 0 0 0 0 0.914 0.757 1.000 214 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(1), ACTR3(1), ARPC4(1), RAC1(1), WASF1(1) 4006826 5 5 5 2 0 2 1 1 1 0 0.813 0.761 1.000 215 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 B4GALT2(1), G6PC2(1), GAA(1), GCK(1), HK2(1), HK3(1), LCT(1), MGAM(2), PFKL(2), PFKM(2), PFKP(2), PGM3(1) 18936220 16 14 16 3 3 3 2 4 4 0 0.279 0.761 1.000 216 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 DPYD(4), ENPP1(2), ENPP3(1), PANK1(1) 8528499 8 8 8 2 4 1 0 2 1 0 0.536 0.764 1.000 217 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD34(1), CD8A(1) 3052993 2 2 2 2 0 1 0 0 1 0 0.947 0.771 1.000 218 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD8A(1), IL7(1), IL9(1) 2993126 3 3 3 3 0 1 0 1 1 0 0.968 0.773 1.000 219 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 JAK1(2), STAT1(1) 4062228 3 2 3 1 0 0 0 2 1 0 0.807 0.776 1.000 220 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 JAK1(2), PLA2G2A(1), STAT1(1) 5668112 4 3 4 1 0 1 0 2 1 0 0.702 0.780 1.000 221 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 31 DUSP1(1), MAP2K4(2), MAPK10(1), MAPK9(1), MAPKAPK5(1), NFKB1(2), NFKBIB(1), PIK3CD(2), SYT1(1), TRAF2(1) 15431560 13 12 13 0 6 5 0 1 1 0 0.0111 0.780 1.000 222 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(1), PSMA2(1), PSMA6(1) 6357250 3 3 3 1 1 2 0 0 0 0 0.721 0.782 1.000 223 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2D(1), DAG1(2), ITPKB(1), ITPR1(1), ITPR2(5), PDE6C(1), TF(2) 17586625 13 13 13 2 2 5 2 2 2 0 0.351 0.783 1.000 224 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 CA12(1), CA14(1), CA2(2), CA3(1), CA5A(1), CA6(1), CA8(1), CA9(1), CPS1(2), GLUD2(1), GLUL(1), HAL(1) 10460630 14 14 14 4 1 6 1 3 3 0 0.563 0.784 1.000 225 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 RPE(1), UGT1A1(2), UGT1A3(1), UGT1A7(1), UGT2B15(3) 8666500 8 6 8 2 4 1 0 2 1 0 0.479 0.785 1.000 226 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 SHMT2(1) 2691562 1 1 1 1 0 0 0 0 1 0 0.903 0.785 1.000 227 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 JAK1(2), JAK3(2), PIAS3(1), STAT3(3) 7493719 8 7 8 2 2 0 1 4 1 0 0.680 0.786 1.000 228 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 17 EGF(2), EGFR(4), PTPRB(1), SHC1(1), SPRY3(1) 12075016 9 9 9 2 2 1 2 4 0 0 0.541 0.794 1.000 229 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 69 ADH4(1), ADHFE1(1), AKR1C1(1), ALDH1A3(1), CYP1A1(1), CYP2B6(2), CYP2C19(2), CYP2C8(2), CYP2S1(1), CYP3A43(2), EPHX1(1), GSTA2(2), GSTA3(1), GSTM2(1), GSTM3(1), GSTO2(1), UGT1A1(2), UGT1A3(1), UGT1A7(1), UGT2A3(1), UGT2B11(2), UGT2B15(3), UGT2B28(1), UGT2B7(1) 28278667 33 30 33 5 7 6 5 13 2 0 0.0974 0.803 1.000 230 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(1), CAMK2D(1), CLCA1(1), CLCA2(2), CLCA4(1), CNGA3(1), CNGA4(1), CNGB1(1), GUCA1A(1), PDE1C(1), PRKACA(1) 15008401 12 12 12 2 1 6 1 3 1 0 0.335 0.804 1.000 231 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 13 CFL1(1) 3545796 1 1 1 1 0 0 0 0 1 0 1.000 0.805 1.000 232 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 19 ACO1(1), CS(2), PC(1), SDHA(1), SDHB(1), SUCLG1(1) 9706933 7 6 7 0 2 1 1 2 1 0 0.161 0.805 1.000 233 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(1), ALDH1A3(1), ALDH1B1(1), CYP2C19(2), DHRS1(1), DHRS7(1), DHRSX(1), EHHADH(5), ESCO1(4), ESCO2(1) 15216224 18 16 18 3 7 4 0 3 4 0 0.262 0.805 1.000 234 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 9 TOP2A(1), TOP2B(1) 4402578 2 2 2 1 0 1 0 0 1 0 0.953 0.810 1.000 235 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 14 APAF1(1), RB1(2) 5437905 3 3 3 0 1 1 0 1 0 0 0.426 0.813 1.000 236 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 GABRA4(1), GPHN(1), UBQLN1(1) 5873875 3 3 3 0 1 0 1 1 0 0 0.480 0.815 1.000 237 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 JAK1(2), JAK3(2), PIAS3(1) 6763430 5 4 5 1 1 0 1 2 1 0 0.652 0.815 1.000 238 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPP(2), DHFR(1), SPR(1) 3204947 4 4 4 4 0 3 0 0 1 0 0.964 0.818 1.000 239 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA4(1) 3892632 1 1 1 0 0 0 1 0 0 0 0.849 0.822 1.000 240 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 LARS(1), LARS2(1) 4936247 2 2 2 0 1 0 0 1 0 0 0.591 0.827 1.000 241 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 24 AKT1(3), APC(2), CD14(1), LEF1(1), LY96(1), NFKB1(2), RELA(2) 13226272 12 12 11 3 2 5 1 2 2 0 0.501 0.828 1.000 242 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CAMK1(1), CAMK2D(1), SYT1(1) 5678528 3 3 3 0 1 0 1 1 0 0 0.486 0.833 1.000 243 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(1), DNMT1(3), DNMT3A(1), MARS(1), MARS2(1), MTR(1) 8548666 8 6 8 1 5 1 0 1 1 0 0.236 0.833 1.000 244 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(1), APAF1(1), DAXX(1), FAS(1), FASLG(1), MAPKAPK3(1) 5584717 6 6 6 5 0 1 1 2 2 0 0.993 0.833 1.000 245 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(2), GALNS(1), HEXB(2), LCT(1), NAGLU(1), SPAM1(1) 10019237 8 7 8 2 2 3 1 1 1 0 0.622 0.837 1.000 246 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 PRKCA(1) 3289206 1 1 1 0 0 0 0 1 0 0 0.857 0.838 1.000 247 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 NEK1(1) 3412059 1 1 1 0 0 1 0 0 0 0 0.786 0.839 1.000 248 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 BET1(1), GOSR1(1), STX10(1), STX16(1) 8196598 4 4 4 1 1 0 0 2 1 0 0.729 0.841 1.000 249 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 32 AGTR1(1), ATF2(2), EGFR(4), MAP2K4(2), MEF2C(1), PRKCA(1), RAC1(1), SHC1(1), SYT1(1) 16185663 14 14 14 3 3 2 2 7 0 0 0.429 0.841 1.000 250 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 8 ACO1(1), SDHB(1) 3970256 2 2 2 0 1 1 0 0 0 0 0.524 0.847 1.000 251 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(1), AMD1(1), DNMT1(3), DNMT3A(1), MARS(1), MARS2(1), MTR(1) 10177294 9 7 9 1 5 1 0 2 1 0 0.207 0.848 1.000 252 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDK(1) 2416459 1 1 1 1 1 0 0 0 0 0 0.936 0.848 1.000 253 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 CPS1(2) 3839921 2 2 2 2 0 1 0 0 1 0 0.956 0.860 1.000 254 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 17 HSPA1A(1), NFKB1(2), RB1(2), RELA(2) 8505266 7 5 7 0 4 1 0 2 0 0 0.125 0.864 1.000 255 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(1), AKT1(3), DAG1(2), ITPKB(1), ITPR1(1), ITPR2(5), NFKB1(2), NFKBIB(1), PDK1(1), PIK3CB(2), PLD1(2) 22059945 21 18 20 4 4 7 4 3 3 0 0.270 0.865 1.000 256 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 14 AKT1(3), BPNT1(1), PDK1(1), PIK3CD(2), RBL2(2), SHC1(1) 8564805 10 10 9 3 1 4 2 2 1 0 0.635 0.866 1.000 257 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 IL12A(1), IL12RB2(1), STAT4(3), TYK2(1) 7177382 6 6 6 2 1 0 1 2 2 0 0.772 0.866 1.000 258 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RANBP2(2) 4154217 2 1 2 1 0 1 0 0 1 0 0.962 0.869 1.000 259 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(1), CDC7(2), MCM2(1), MCM3(1), MCM4(1), MCM5(1), MCM6(1), MCM7(1), NACA(1), POLD3(1), POLE(3), RFC2(1), RFC3(1), RPA1(1), RPA2(1), UBB(1), UBC(1) 24931291 20 15 20 2 6 6 1 5 2 0 0.0575 0.869 1.000 260 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 TRAF2(1) 4089381 1 1 1 0 1 0 0 0 0 0 0.705 0.882 1.000 261 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 IL10RA(1), JAK1(2), STAT1(1), STAT3(3), STAT5A(1) 6003104 8 6 8 2 2 0 0 5 1 0 0.666 0.883 1.000 262 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 10 MYT1(1), RB1(2) 5168520 3 3 3 1 2 0 0 1 0 0 0.731 0.883 1.000 263 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CAMK1(1), CAMK2D(1), MEF2C(1), PPP3CA(1), PPP3CC(1), SYT1(1) 9908223 6 5 6 0 1 0 2 3 0 0 0.264 0.883 1.000 264 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH4(1), ADHFE1(1), AGPAT2(1), AGPAT3(1), AGPAT4(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), DGKD(3), DGKQ(1), DGKZ(1), GK(1), LCT(1), PNLIPRP1(2), PPAP2A(1) 23611503 20 18 20 3 2 5 4 5 4 0 0.223 0.885 1.000 265 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 FLT3(1), IL9(1) 4065467 2 2 2 3 0 0 0 1 1 0 0.991 0.889 1.000 266 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(1), IFNB1(1), IL12A(1), ITGAX(3) 9175859 6 6 6 2 1 1 1 0 3 0 0.718 0.893 1.000 267 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(1), BIRC2(1), SCAP(1), SREBF2(1) 8987006 4 4 4 1 0 2 0 2 0 0 0.651 0.893 1.000 268 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 23 FLT1(1), KDR(4), NOS3(2), PRKCA(1), SHC1(1), VHL(2) 15415143 11 11 11 2 4 4 1 1 1 0 0.386 0.896 1.000 269 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 ITGA4(1), ITGAL(2), ITGAM(1), ITGB2(1), SELE(2), SELP(2) 7823955 9 9 9 3 2 3 1 3 0 0 0.727 0.901 1.000 270 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLE(3), POLG(1), POLQ(1) 8236216 5 5 5 1 2 2 0 1 0 0 0.521 0.901 1.000 271 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 11 EGR1(1), KLK2(1) 3825685 2 2 2 2 0 1 0 0 1 0 0.968 0.901 1.000 272 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(2), ACE2(1), AGTR1(1), ANPEP(1), CMA1(1), CTSA(1), ENPEP(1), MAS1(1), MME(2) 10400699 11 11 11 3 3 5 1 2 0 0 0.558 0.903 1.000 273 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(1) 4700525 1 1 1 1 1 0 0 0 0 0 0.964 0.904 1.000 274 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 7 SHC1(1) 4109940 1 1 1 1 0 1 0 0 0 0 0.927 0.905 1.000 275 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(1), BAD(1), CASP1(1), CD40(1), DAXX(1), FAS(1), FASLG(1), LTA(1), MCL1(1), NFKB1(2), NTRK1(1), TFG(1), TRAF2(1) 21378285 14 13 14 1 5 4 0 2 3 0 0.114 0.906 1.000 276 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 THBS1(1) 3646982 1 1 1 1 0 0 0 1 0 0 0.943 0.906 1.000 277 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 CTSD(1), GREB1(1), MTA1(1), MTA3(1) 5309050 4 4 4 2 2 2 0 0 0 0 0.759 0.907 1.000 278 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(1), BIRC2(1), CFLAR(1), LMNA(1), NFKB1(2), RELA(2), SPTAN1(1), TNFRSF10A(1), TNFRSF10B(1), TRAF2(1) 16397083 12 12 12 2 5 5 0 1 1 0 0.289 0.907 1.000 279 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 17 ABL1(1), BRCA1(2), NFKB1(2), RELA(2) 11223787 7 6 7 1 3 1 0 3 0 0 0.382 0.907 1.000 280 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 GOT2(1) 4281056 1 1 1 0 0 1 0 0 0 0 0.725 0.911 1.000 281 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH4(1), ADHFE1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), ALDOC(2), ENO1(2), GCK(1), GPI(1), HK2(1), HK3(1), PFKM(2), PFKP(2), PGK1(1), PGM3(1), TPI1(1) 24039266 22 19 22 4 5 5 3 5 4 0 0.201 0.912 1.000 282 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH4(1), ADHFE1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), ALDOC(2), ENO1(2), GCK(1), GPI(1), HK2(1), HK3(1), PFKM(2), PFKP(2), PGK1(1), PGM3(1), TPI1(1) 24039266 22 19 22 4 5 5 3 5 4 0 0.201 0.912 1.000 283 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(2), POLR1B(1), POLR1C(1), POLR2B(1), POLR3A(2) 11540660 7 7 7 2 3 1 2 1 0 0 0.646 0.925 1.000 284 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 GBGT1(1), HEXB(2), NAGA(2), ST3GAL1(1) 4969106 6 6 6 4 2 3 0 0 1 0 0.916 0.928 1.000 285 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP2A13(2), CYP2A6(1) 3940625 3 3 3 2 0 2 0 1 0 0 0.861 0.928 1.000 286 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 19 BRCA1(2), BRCA2(4), FANCA(1), FANCC(1), FANCD2(1), FANCF(1), FANCG(1), TREX1(1) 18280527 12 10 12 1 4 2 1 2 3 0 0.257 0.930 1.000 287 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 24 CSNK2A1(1), EGF(2), EGFR(4), JAK1(2), MAP2K4(2), PRKCA(1), SHC1(1), STAT1(1), STAT3(3), STAT5A(1) 17110118 18 15 18 4 5 2 1 9 1 0 0.406 0.935 1.000 288 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 PRKCA(1) 4709002 1 1 1 1 0 0 0 1 0 0 0.971 0.937 1.000 289 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 MAP3K7(1), NFKB1(2), RELA(2), TNFAIP3(1) 11866380 6 6 6 1 2 1 0 1 2 0 0.552 0.937 1.000 290 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 20 CFL1(1), LIMK1(1), PLCB1(3), PRKCA(1), ROCK2(1) 12088662 7 6 7 0 2 3 0 1 1 0 0.183 0.937 1.000 291 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 18 APAF1(1), BIRC2(1) 6640164 2 2 2 0 0 2 0 0 0 0 0.569 0.938 1.000 292 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 GBGT1(1), HEXB(2), NAGA(2), ST3GAL1(1) 5275825 6 6 6 4 2 3 0 0 1 0 0.921 0.940 1.000 293 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(1), BIRC2(1), CASP1(1), LMNA(1) 9527513 4 4 4 1 0 3 0 0 1 0 0.729 0.940 1.000 294 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 CAPNS1(1) 4545485 1 1 1 1 0 0 0 1 0 0 0.948 0.942 1.000 295 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(1), HNF4A(1), NR1D2(2), NR1H3(1), NR1I3(2), NR2F1(1), NR5A2(1), PGR(2), PPARG(1) 20515668 12 12 12 1 2 2 1 4 3 0 0.179 0.942 1.000 296 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 20 ARHGAP5(2), ITGA1(1), MYLK(3), PFN1(1), ROCK1(4), SHC1(1), TLN1(2) 17135770 14 13 13 3 1 3 2 5 3 0 0.587 0.942 1.000 297 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 CAD(2), CANT1(1), CTPS2(1), DPYD(4), ENTPD3(1), ENTPD6(1), ENTPD8(1), NME1(1), NT5E(1), POLA1(1), POLD3(1), POLE(3), POLR1A(2), POLR1B(1), POLR1C(1), POLR2B(1), POLR3A(2), PRIM2(1), RRM1(3), RRM2B(1), TXNRD1(1), TYMS(1), UCK2(1), UMPS(1), UPP1(1) 39779483 35 27 35 5 12 4 3 11 5 0 0.0693 0.944 1.000 298 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 21 CRK(1), NFKB1(2), PRKCA(1), RELA(2) 12218236 6 6 6 0 2 1 0 3 0 0 0.197 0.945 1.000 299 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH4(1), ADHFE1(1), AGK(1), AGPAT2(1), AGPAT3(1), AGPAT4(1), ALDH1A3(1), ALDH1B1(1), DAK(1), DGAT2(1), DGKD(3), DGKI(4), DGKQ(1), DGKZ(1), GK(1), LCT(1), MGLL(1), PNLIPRP1(2), PPAP2A(1) 28783072 25 23 25 4 4 4 5 6 6 0 0.208 0.948 1.000 300 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 IFNB1(1), IL12A(1), IL7(1), LTA(1) 6542511 4 4 4 3 1 1 0 0 2 0 0.959 0.948 1.000 301 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 12 CCNE2(1) 4210157 1 1 1 1 0 0 0 1 0 0 0.950 0.949 1.000 302 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD8A(1), ITGAL(2), ITGB2(1), PTPRC(3) 5293080 7 7 7 6 1 3 0 2 1 0 0.975 0.950 1.000 303 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(1), ITGAL(2), ITGB2(1) 4295718 4 4 4 4 1 2 0 0 1 0 0.961 0.950 1.000 304 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(1), HEMK1(1), MARS(1), MARS2(1), METTL6(1), PAPSS2(1), PRMT3(2), PRMT5(2), SEPHS1(1), SEPHS2(2) 12265090 13 12 13 5 2 3 0 4 4 0 0.730 0.951 1.000 305 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 20 CSNK2A1(1), IL6ST(3), JAK1(2), JAK3(2), SHC1(1), STAT3(3) 11467520 12 10 12 4 3 1 1 3 4 0 0.797 0.951 1.000 306 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(4), PPP1CA(1) 5701401 5 5 5 3 0 0 0 4 1 0 0.923 0.951 1.000 307 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 7 MYT1(1) 3683046 1 1 1 1 1 0 0 0 0 0 0.927 0.952 1.000 308 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(1), ACTR3(1), ARPC4(1), NTRK1(1), RAC1(1), WASF1(1), WASF2(1), WASF3(1) 7529058 8 8 8 4 0 4 1 1 2 0 0.920 0.962 1.000 309 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 CDC34(1), UBE2D1(1), UBE2I(1), UBE2L3(1) 5183827 4 3 4 2 2 2 0 0 0 0 0.858 0.963 1.000 310 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG12(1), IFNA10(1), IFNA13(1), IFNA16(2), IFNA17(1), IFNA21(1), IFNA6(1), PRKAA2(2) 10395665 10 10 10 3 2 2 0 5 1 0 0.719 0.968 1.000 311 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ALDH1A3(1), AOC2(2), DDC(1), EPX(1), ESCO1(4), ESCO2(1), GOT2(1), MAOA(1), MPO(1), TPO(1) 16769574 14 13 14 4 4 4 1 1 4 0 0.595 0.972 1.000 312 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(2), ACSS2(1), ADH4(1), ADHFE1(1), ALDH1A3(1), ALDH1B1(1), ALDOC(2), ENO1(2), G6PC2(1), GCK(1), GPI(1), HK2(1), HK3(1), PFKL(2), PFKM(2), PFKP(2), PGK1(1), PGK2(1), PGM3(1), TPI1(1) 28619988 26 24 26 5 7 4 2 7 6 0 0.179 0.974 1.000 313 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 ARSD(1), ARSE(1), CYP11B2(1), CYP19A1(1), HEMK1(1), HSD11B1(1), HSD3B1(1), HSD3B2(1), METTL6(1), PRMT3(2), PRMT5(2), STS(1), SULT1E1(1), UGT1A1(2), UGT1A3(1), UGT1A7(1), UGT2A3(1), UGT2B11(2), UGT2B15(3), UGT2B28(1), UGT2B7(1) 24694487 27 22 27 7 5 2 2 9 9 0 0.451 0.975 1.000 314 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 PRKCA(1), SYT1(1) 6771094 2 2 2 1 1 0 0 1 0 0 0.840 0.976 1.000 315 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 36 CAMK1(1), NCF2(1), NFATC2(1), NFATC4(1), NFKB1(2), PLCB1(3), PPP3CA(1), PPP3CC(1), RAC1(1), RELA(2), SYT1(1) 18518880 15 12 15 3 7 3 1 4 0 0 0.286 0.977 1.000 316 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A1(1), ATP6V0D1(1), ATP6V1A(2), ATP6V1B2(1), ATP6V1C2(3) 7408602 8 7 8 3 4 0 2 1 1 0 0.725 0.977 1.000 317 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A1(1), ATP6V0D1(1), ATP6V1A(2), ATP6V1B2(1), ATP6V1C2(3) 7408602 8 7 8 3 4 0 2 1 1 0 0.725 0.977 1.000 318 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A1(1), ATP6V0D1(1), ATP6V1A(2), ATP6V1B2(1), ATP6V1C2(3) 7408602 8 7 8 3 4 0 2 1 1 0 0.725 0.977 1.000 319 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 MRPL13(1), RPL10A(2), RPL11(2), RPL28(1), RPL7(1), RPS10(1) 11230363 8 8 8 3 1 2 0 4 1 0 0.759 0.981 1.000 320 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 13 ACTR3(1), ARPC4(1), RAC1(1) 5532316 3 3 3 2 0 1 0 1 1 0 0.912 0.981 1.000 321 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 12 CTNNA1(1), CTNNA2(1) 8600184 2 2 2 0 0 1 0 1 0 0 0.589 0.981 1.000 322 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 50 ABL1(1), ACTG1(2), ARHGEF2(2), ARPC5L(1), CD14(1), CDH1(2), EZR(1), KRT18(1), LY96(1), PRKCA(1), ROCK1(4), ROCK2(1), TLR5(1), TUBA1C(1), TUBA3C(3), TUBB1(1), TUBB2B(1), TUBB8(1), WAS(1) 25037468 27 27 26 6 4 8 3 9 3 0 0.389 0.981 1.000 323 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 50 ABL1(1), ACTG1(2), ARHGEF2(2), ARPC5L(1), CD14(1), CDH1(2), EZR(1), KRT18(1), LY96(1), PRKCA(1), ROCK1(4), ROCK2(1), TLR5(1), TUBA1C(1), TUBA3C(3), TUBB1(1), TUBB2B(1), TUBB8(1), WAS(1) 25037468 27 27 26 6 4 8 3 9 3 0 0.389 0.981 1.000 324 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(1), CAPNS1(1), ITGA1(1), RAC1(1), SPTAN1(1), TLN1(2) 14039613 7 7 7 2 1 0 2 3 1 0 0.665 0.983 1.000 325 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AGXT(1), ASPA(1), CAD(2), DDO(1), GAD1(1), GAD2(3), GOT2(1), GPT(1), PC(1) 12826108 12 12 12 4 2 3 2 2 3 0 0.779 0.983 1.000 326 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 GFPT2(1), GNPNAT1(1), HEXB(2), HK2(1), HK3(1), MTMR2(1), MTMR6(1), NAGK(1), PGM3(1) 14095011 10 10 10 3 1 3 1 3 2 0 0.758 0.984 1.000 327 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 18 CSNK2A1(1), IGF1R(2), IRS1(2), SHC1(1) 10864178 6 5 6 2 1 1 0 3 1 0 0.750 0.984 1.000 328 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 DAB1(2), LRP8(1), RELN(2), VLDLR(1) 6915912 6 6 6 3 1 1 0 3 1 0 0.903 0.984 1.000 329 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB11(2) 7052447 2 2 2 3 1 0 0 0 1 0 0.990 0.985 1.000 330 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 40 APAF1(1), BIRC2(1), FAS(1), FASLG(1), MAP2K4(2), MAPK10(1), MCL1(1), NFKB1(2), PARP1(2), RELA(2), TRAF2(1) 17947564 15 15 15 4 4 7 0 3 1 0 0.467 0.987 1.000 331 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(2), LDLR(1), MBTPS1(1), SCAP(1), SREBF2(1) 5854042 6 6 6 3 0 1 0 4 1 0 0.888 0.987 1.000 332 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH4(1), ADHFE1(1), ALDH1A3(1), ALDH1B1(1) 6525777 4 4 4 2 1 1 0 2 0 0 0.842 0.987 1.000 333 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 23 ACTA1(1), CAPNS1(1), EGF(2), EGFR(4), ITGA1(1), MYLK(3), TLN1(2) 15812024 14 14 14 4 3 1 3 6 1 0 0.640 0.987 1.000 334 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(1), C6(4), C9(2) 6203052 7 7 7 4 2 4 0 0 1 0 0.910 0.987 1.000 335 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 CFLAR(1), DAXX(1), FAF1(1), LMNA(1), MAP2K4(2), MAP3K7(1), PAK2(1), PRKDC(3), RB1(2), RIPK2(2), SPTAN1(1) 20009069 16 14 16 3 3 3 1 6 3 0 0.439 0.988 1.000 336 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 CAD(2), CANT1(1), CTPS2(1), DPYD(4), NME1(1), NT5E(1), POLE(3), POLG(1), POLQ(1), POLR1B(1), POLR2B(1), RRM1(3), TXNRD1(1), TYMS(1), UCK2(1), UMPS(1), UPP1(1) 28166208 25 21 25 5 7 4 1 10 3 0 0.279 0.988 1.000 337 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 PGAP1(1), PIGA(1), PIGO(1), PIGT(1) 11710680 4 4 4 0 1 2 0 1 0 0 0.290 0.988 1.000 338 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 B3GNT2(1), B3GNT3(1), B3GNT4(1), B4GALT2(1), B4GALT4(1), ST3GAL6(1) 7954625 6 6 6 3 2 1 1 1 0 1 0.901 0.989 1.000 339 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA1(3), ACAA2(1), ACADSB(1), ACAT1(1), ACOX1(1), ACOX3(1), ADH4(1), ADHFE1(1), ALDH1A3(1), ALDH1B1(1), CPT1B(1), CPT1C(1), EHHADH(5), HSD17B4(1) 24128097 20 16 20 4 5 3 1 6 5 0 0.321 0.989 1.000 340 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 11 APC(2) 9747737 2 2 2 2 0 0 0 0 2 0 0.983 0.989 1.000 341 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT2(1), AGPAT3(1), AGPAT4(1), ENPP2(2), PLA2G2A(1), PLA2G4A(1), PLD1(2), PPAP2A(1) 11406026 10 9 10 4 1 3 2 1 3 0 0.807 0.989 1.000 342 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA1(3), ACAA2(1), ACADSB(1), ACAT1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), AOX1(2), BCKDHA(1), EHHADH(5), HMGCL(2), IVD(1) 17740250 22 17 22 8 4 4 3 4 7 0 0.804 0.990 1.000 343 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), AOC2(2), ASPA(1), CNDP1(1), DDC(1), HAL(1), HARS(1), HDC(1), MAOA(1) 11968004 14 11 14 6 5 4 1 1 3 0 0.820 0.990 1.000 344 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 15 B3GAT3(1), CHPF(1), CHST12(1), CHSY1(1), XYLT1(2) 6711824 6 6 6 3 2 1 1 1 1 0 0.833 0.990 1.000 345 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 IL12A(1), IL12RB2(1), STAT4(3), TYK2(1) 9132156 6 6 6 4 1 0 1 2 2 0 0.954 0.990 1.000 346 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 HMGCS1(2), LSS(1) 6438484 3 3 3 4 1 0 0 1 1 0 0.992 0.990 1.000 347 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACAA1(3), ACOX1(1), ACOX3(1), CPT1B(1), CPT1C(1), CYP7A1(1), CYP8B1(1), EHHADH(5), FABP1(1), FABP2(1), FABP3(1), FABP4(1), FADS2(1), GK(1), MMP1(2), NR1H3(1), PCK2(1), PPARG(1), SLC27A4(1), SLC27A5(1), SLC27A6(1), SORBS1(2), UBC(1) 32178790 31 25 30 6 9 4 1 11 6 0 0.237 0.990 1.000 348 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(3), EBP(1), GGCX(1), LSS(1), TM7SF2(1) 9409730 7 7 7 3 1 3 0 1 2 0 0.857 0.990 1.000 349 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 LMNA(1), MADD(3), MAP2K4(2), MAP3K7(1), PAK2(1), PRKDC(3), RB1(2), SPTAN1(1), TRAF2(1) 19002383 15 12 15 3 6 2 1 3 3 0 0.414 0.991 1.000 350 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 IL12A(1), IL12RB2(1), IL4R(3) 6252386 5 4 5 2 1 0 1 1 2 0 0.816 0.991 1.000 351 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 49 ACOX1(1), CITED2(1), CPT1B(1), CREBBP(2), DUSP1(1), EHHADH(5), FABP1(1), HSD17B4(1), HSPA1A(1), NCOA1(2), NCOR1(6), NR1H3(1), NR2F1(1), NRIP1(2), PRKCA(1), PTGS2(2), RB1(2), RELA(2), SP1(2), STAT5A(1), STAT5B(1) 30025424 37 30 37 8 11 10 0 8 8 0 0.268 0.991 1.000 352 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 LTA(1), MAP2K4(2), NFKB1(2), RELA(2), TANK(1), TRAF2(1) 11782062 9 8 9 3 4 2 0 3 0 0 0.646 0.991 1.000 353 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(1), B4GALNT1(1), HEXB(2), LCT(1), ST3GAL1(1), ST6GALNAC4(1), ST6GALNAC5(1), ST8SIA5(1) 8127989 9 7 9 6 3 4 0 1 1 0 0.926 0.991 1.000 354 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 24 ADCY1(1), AKT1(3), CAMK2D(1), PRKCA(1), RAC1(1), RPS6KA5(2) 13034410 9 9 8 3 1 2 2 4 0 0 0.788 0.991 1.000 355 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 CARS(1), EPRS(1), GARS(1), HARS(1), LARS(1), LARS2(1), MARS(1), MARS2(1), QARS(2) 15815368 10 9 10 2 5 2 0 2 1 0 0.450 0.991 1.000 356 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6V0A1(1), ATP6V0D1(1), ATP6V1A(2), ATP6V1B2(1), ATP6V1C2(3) 7874541 8 7 8 4 4 0 2 1 1 0 0.857 0.992 1.000 357 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(1), EPHA4(1), EPHB1(2), ITGA1(1), L1CAM(2), LYN(1), SELP(2) 7758058 10 9 10 6 3 1 2 3 1 0 0.943 0.992 1.000 358 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 BTG1(1), CRY1(1), DAZAP2(1), ETV6(1), GSTM3(1), HERPUD1(1), HSPA8(5), NCOA4(2), NR1D2(2), PER1(2), PER2(1), SF3A3(1), VAPA(2), ZFR(1) 17988363 22 20 22 6 5 3 2 7 5 0 0.654 0.992 1.000 359 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 NFATC2(1) 5959965 1 1 1 1 1 0 0 0 0 0 0.944 0.992 1.000 360 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(2), GRM1(4), GRM2(1), GRM5(1), GRM8(1) 10345592 9 9 9 4 4 2 1 0 2 0 0.760 0.993 1.000 361 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(2), CDH1(2), CREBBP(2), MAP3K7(1), TGFBR1(1) 12666520 8 7 8 4 1 0 1 3 3 0 0.941 0.993 1.000 362 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(2), ANAPC2(1), ANAPC4(1), ANAPC5(1), ANAPC7(1), CDC16(1), CDC20(2), CDC27(1), CUL2(3), CUL3(1), FBXW11(2), FZR1(1), SMURF2(1), TCEB2(1), UBE2D1(1), VHL(2), WWP1(1) 19750993 23 23 23 5 2 5 2 8 6 0 0.547 0.993 1.000 363 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP1(1), ACPT(1), ALPP(2), CYP19A1(1), CYP1A1(1), CYP2A13(2), CYP2A6(1), CYP2B6(2), CYP2C19(2), CYP2C8(2), CYP2J2(1), PON1(1) 14432115 17 16 17 7 0 6 1 7 3 0 0.795 0.994 1.000 364 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 DLG4(1), GRIN1(1), GRIN2A(6), GRIN2B(5), NOS1(1), PPP3CA(1), PPP3CC(1), PRKCA(1), SYT1(1) 12547055 18 18 18 5 3 6 4 4 1 0 0.506 0.995 1.000 365 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 28 BAD(1), DUSP4(1), DUSP9(1), EIF4E(1), NFKB1(2), RPS6KA3(1), SHC1(1) 13780565 8 6 8 2 5 1 0 1 1 0 0.492 0.995 1.000 366 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 16 CSNK2A1(1), KLK2(1), SHC1(1) 8060408 3 3 3 2 1 1 0 0 1 0 0.927 0.995 1.000 367 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 22 ABL1(1), DHFR(1), RB1(2), TFDP1(1) 11225518 5 5 5 2 1 0 0 3 1 0 0.869 0.995 1.000 368 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ALDH18A1(1), ARG2(1), CKB(1), CKMT1B(1), CKMT2(1), CPS1(2), PYCR1(1) 8586618 8 7 8 4 3 2 1 1 1 0 0.834 0.995 1.000 369 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 13 APC(2), CREBBP(2), LEF1(1), TRRAP(3) 15565488 8 8 8 7 1 1 0 2 4 0 0.989 0.995 1.000 370 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ALDH1A3(1), AOC2(2), DDC(1), EPX(1), GOT2(1), MAOA(1), MPO(1), TPO(1) 10728999 9 8 9 4 2 3 1 1 2 0 0.806 0.996 1.000 371 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 21 APC(2), CREBBP(2), CSNK2A1(1), MAP3K7(1), WIF1(2) 13677420 8 8 8 5 3 0 0 2 3 0 0.966 0.996 1.000 372 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 19 B2M(1), RAC1(1), SYK(2) 8075675 4 4 4 4 0 2 0 1 1 0 0.984 0.996 1.000 373 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(1), CASP1(1), INSR(1), MAGI1(1), MAGI2(1), WWP1(1) 11817584 6 5 6 2 2 2 0 2 0 0 0.728 0.996 1.000 374 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 23 GH1(1), GHR(2), INSR(1), IRS1(2), PRKCA(1), SHC1(1), STAT5A(1), STAT5B(1) 14997187 10 9 10 3 4 2 1 2 1 0 0.651 0.997 1.000 375 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ADH4(1), ADHFE1(1), ALDH1A3(1), AOC2(2), AOX1(2), DBH(2), DDC(1), ESCO1(4), ESCO2(1), GOT2(1), HEMK1(1), MAOA(1), METTL6(1), PRMT3(2), PRMT5(2), TPO(1), TYRP1(2) 29207291 26 24 26 9 5 6 0 6 9 0 0.745 0.997 1.000 376 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(2), NFKB1(2), RELA(2), TRAF2(1) 9519873 7 7 7 3 3 1 1 2 0 0 0.803 0.997 1.000 377 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AADAC(1), ACAT1(1), ACSM1(1), ALDH1A3(1), ALDH1B1(1), DDHD1(2), EHHADH(5), GAD1(1), GAD2(3), HMGCL(2), HMGCS1(2), HSD17B4(1) 19937207 21 19 21 6 4 3 3 5 6 0 0.619 0.997 1.000 378 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 21 INPPL1(1), ITPKB(1), OCRL(1), PIK3C2A(1), PIK3CB(2), PIK3CG(1), PLCB1(3), PLCG2(1) 19672941 11 9 11 3 3 4 0 3 1 0 0.501 0.997 1.000 379 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ACACA(1), ACADSB(1), ACAT1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), EHHADH(5), SUCLG1(1) 16317449 14 12 14 6 3 3 2 2 4 0 0.899 0.997 1.000 380 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1S(2), C3(1), C6(4), C9(2) 8608283 9 9 9 5 2 4 0 2 1 0 0.911 0.998 1.000 381 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 21 CFL1(1), CHN1(1), LIMK1(1), MYLK(3), NCF2(1), PLD1(2), RAC1(1), TRIO(4), WASF1(1) 16097630 15 14 15 5 4 3 1 4 3 0 0.746 0.998 1.000 382 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG5(1), B4GALT2(1), DPAGT1(1), FUT8(1), MGAT5(1), ST6GAL1(2) 9768514 7 7 7 3 4 1 1 1 0 0 0.729 0.999 1.000 383 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 26 AKT1(3), BAD(1), IL4R(3), IRS1(2), JAK1(2), JAK3(2), PDK1(1), PIK3CD(2), SHC1(1) 16899197 17 15 16 5 2 4 4 3 4 0 0.646 0.999 1.000 384 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AADAT(1), AASDH(1), AASDHPPT(1), AASS(1), ACAT1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), BBOX1(1), DOT1L(2), EHHADH(5), EHMT2(1), PLOD1(1), PLOD3(1), SHMT2(1) 18191172 22 19 22 7 6 4 3 5 4 0 0.612 0.999 1.000 385 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 CP(3), EPRS(1), HMBS(1), UGT1A1(2), UGT1A3(1), UGT1A7(1), UGT2B15(3) 13511500 12 11 12 7 4 2 1 3 2 0 0.925 0.999 1.000 386 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 CAD(2), CPS1(2), EPRS(1), GAD1(1), GAD2(3), GLUL(1), GOT2(1), GPT(1), QARS(2) 16356644 14 13 14 5 3 4 1 3 3 0 0.743 0.999 1.000 387 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 CAD(2), CPS1(2), EPRS(1), GAD1(1), GAD2(3), GFPT2(1), GLUD2(1), GLUL(1), GNPNAT1(1), GOT2(1), GPT(1), NAGK(1), QARS(2) 19452125 18 17 18 7 3 6 1 4 4 0 0.817 0.999 1.000 388 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ADH4(1), ADHFE1(1), ALDH1A3(1), AOC2(2), AOX1(2), DBH(2), DDC(1), GOT2(1), MAOA(1), TPO(1) 15539269 13 12 13 5 2 4 0 4 3 0 0.790 0.999 1.000 389 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 CD97(1), ELTD1(1), EMR2(3), GHRHR(1), GIPR(1), GLP1R(1), GLP2R(3), GPR64(1), LPHN1(1), LPHN2(1), LPHN3(4), VIPR1(1) 13069231 19 19 19 7 3 1 1 12 2 0 0.795 0.999 1.000 390 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 24 CSNK2A1(1), JAK1(2), MAP2K4(2), PRKCA(1), SHC1(1), STAT1(1), STAT3(3), STAT5A(1) 15847386 12 9 12 4 3 2 0 6 1 0 0.678 0.999 1.000 391 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(1), COL4A2(2), COL4A4(2), SLC23A2(1) 12186134 6 6 6 2 1 3 0 0 2 0 0.853 0.999 1.000 392 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 29 AKT1(3), CAMK1(1), IGF1R(2), INSR(1), MEF2C(1), NFATC2(1), PPP3CA(1), PPP3CC(1), SYT1(1) 15982507 12 10 11 4 3 2 2 5 0 0 0.692 0.999 1.000 393 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ALDH18A1(1), ALDH1A3(1), ALDH1B1(1), AMD1(1), AOC2(2), ARG2(1), CPS1(2), MAOA(1), SAT2(1) 14419327 11 10 11 7 5 2 0 2 2 0 0.951 0.999 1.000 394 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(2), DAG1(2), ITPKB(1), MAP2K4(2), MAPK10(1), MAPK9(1) 14056046 9 8 9 4 2 3 1 1 2 0 0.834 0.999 1.000 395 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AGXT(1), ASPA(1), CAD(2), DDO(1), GAD1(1), GAD2(3), GOT2(1), GPT(1), PC(1) 18608959 12 12 12 4 2 3 2 2 3 0 0.781 0.999 1.000 396 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 47 AKT1(3), BRD4(1), INPPL1(1), IRS1(2), PDK1(1), PIK3CD(2), RPS6KA3(1), SHC1(1), SORBS1(2) 27833822 14 13 13 3 1 5 3 2 3 0 0.448 0.999 1.000 397 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1S(2), C3(1), C6(4), C9(2), MASP1(1) 10232615 10 10 10 5 2 4 0 3 1 0 0.884 0.999 1.000 398 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 19 CSNK2A1(1), INSR(1), IRS1(2), SHC1(1) 11189700 5 5 5 3 2 1 0 1 1 0 0.921 0.999 1.000 399 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 IFNB1(1), IRAK2(1), MAP3K7(1), NFKB1(2), RELA(2) 14517576 7 7 7 5 2 2 0 1 2 0 0.981 0.999 1.000 400 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 80 ACVR1B(1), ACVRL1(1), AKT1(3), AURKB(1), BMPR1A(1), BMPR2(1), BUB1(1), CDKL2(1), CDS1(1), CLK1(1), CLK2(1), COL4A3BP(1), CSNK2A1(1), CSNK2A2(1), DGKD(3), DGKQ(1), DGKZ(1), INPPL1(1), ITPKB(1), NEK1(1), OCRL(1), PIK3C2A(1), PIK3CB(2), PIK3CG(1), PLCB1(3), PLCG2(1), PLK3(3), PRKACA(1), PRKCA(1), PRKCG(1), PRKD1(1), RPS6KA3(1), TGFBR1(1) 53074379 42 38 41 7 6 13 5 14 4 0 0.105 0.999 1.000 401 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR1(1), ATP8A1(1), AVPR1A(3), AVPR1B(1), BRS3(1), CCKAR(1), CCKBR(1), CCR1(1), CCR2(3), CCR4(1), LHCGR(1), MC4R(1), NPY1R(1), NPY2R(2), OPRL1(1), OXTR(1), SSTR1(2), TACR1(1), TACR3(3), TSHR(1) 25728469 28 24 28 8 7 9 3 5 4 0 0.351 1.000 1.000 402 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 ACTG1(2), APAF1(1), BIRC2(1), CFLAR(1), DAXX(1), LMNA(1), NFKB1(2), NUMA1(1), PAK2(1), PRKDC(3), RB1(2), RELA(2), SPTAN1(1), TRAF2(1) 33955858 20 17 20 4 6 6 1 5 2 0 0.350 1.000 1.000 403 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1S(2), C3(1), C6(4), C9(2), MASP1(1), MASP2(1) 10479506 11 11 11 5 2 4 0 4 1 0 0.853 1.000 1.000 404 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 58 BTK(1), CAD(2), DAXX(1), EGFR(4), FAF1(1), MAP2K4(2), MAPK10(1), MAPK9(1), MET(3), NFKB1(2), NFKBIB(1), PFN1(1), PFN2(2), ROCK1(4), TNFRSF6B(1), TPX2(1), TRAF2(1) 35345790 29 25 28 6 10 3 2 10 4 0 0.271 1.000 1.000 405 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 31 APC(2), ATF2(2), BMP4(1), BMPR1A(1), BMPR2(1), MAP3K7(1), MEF2C(1), NPPB(1), TGFBR1(1), TGFBR3(1) 17124043 12 11 12 7 1 3 1 4 3 0 0.965 1.000 1.000 406 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(1), COL4A2(2), COL4A4(2), F11(3), F2(1), F2R(1), F5(4), F8(3), FGA(4), FGB(1), PROC(1), PROS1(2) 21744198 25 25 25 7 7 6 3 4 5 0 0.774 1.000 1.000 407 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 21 CSNK2A1(1), JAK1(2), JAK3(2), SHC1(1), STAT5A(1), STAT5B(1), SYK(2) 11150903 10 9 10 5 3 4 1 1 1 0 0.842 1.000 1.000 408 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 AGXT(1), ALAS1(1), ALAS2(1), AOC2(2), CPT1B(1), DAO(1), GARS(1), GLDC(2), MAOA(1), PLCG2(1), SARDH(1), SHMT2(1) 20530391 14 13 14 5 4 0 3 3 4 0 0.801 1.000 1.000 409 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 25 AKT1(3), IL13RA1(1), IL4R(3), INPP5D(1), JAK1(2), JAK3(2), SHC1(1), TYK2(1) 17063350 14 13 13 6 1 4 3 3 3 0 0.863 1.000 1.000 410 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 AGXT(1), ALAS1(1), ALAS2(1), AOC2(2), DAO(1), GARS(1), GLDC(2), MAOA(1), SARDH(1), SHMT2(1), TARS2(1) 20889781 13 12 13 6 5 0 3 1 4 0 0.908 1.000 1.000 411 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSB(2), ARSD(1), ARSE(1), GAL3ST1(1), LCT(1), NEU4(1), PPAP2A(1), SMPD2(2), SPTLC2(1) 11856491 11 11 11 5 2 2 1 5 1 0 0.836 1.000 1.000 412 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 56 BMP4(1), BMP6(1), CSNK1G1(1), CSNK1G3(1), DHH(1), FBXW11(2), GLI1(3), GLI2(2), GLI3(2), HHIP(3), LRP2(2), PRKACA(1), PTCH2(3), SHH(1), STK36(1), WNT2(1), WNT6(1), WNT9A(1) 29940508 28 27 28 7 2 13 1 9 3 0 0.334 1.000 1.000 413 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA1(3), ACAA2(1), ADH4(1), ADHFE1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), CYP7A1(1) 11430989 12 10 12 5 2 3 1 5 1 0 0.789 1.000 1.000 414 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 AKT1(3), APC(2), CAV3(1), DAG1(2), DLG4(1), ITPR1(1), ITPR2(5), RAC1(1), RYR1(2) 22526372 18 18 17 7 2 5 3 4 4 0 0.827 1.000 1.000 415 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 31 ACTR3(1), AKT1(3), DAG1(2), ETFA(1), ITGA9(2), ITPKB(1), ITPR1(1), ITPR2(5), NR1I3(2), PDE3B(1), PIK3CD(2) 22840366 21 21 20 6 1 11 2 3 4 0 0.602 1.000 1.000 416 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 GALNT10(1), GALNT11(1), GALNT13(1), GALNT14(1), GALNT3(1), GALNT4(1), GALNT8(1), GALNTL5(1), OGT(1), ST3GAL1(1), ST6GALNAC1(1), WBSCR17(1) 15889504 12 11 12 5 1 6 0 3 2 0 0.820 1.000 1.000 417 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG12(1), ALG14(1), ALG5(1), B4GALT2(1), DPAGT1(1), FUT8(1), GANAB(1), MAN1A2(1), MAN2A1(3), MGAT5(1), MGAT5B(1), ST6GAL1(2) 20713763 15 14 15 7 5 1 1 4 4 0 0.913 1.000 1.000 418 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 15 CREBBP(2), IL7(1), IL7R(1), JAK1(2), JAK3(2), STAT5A(1), STAT5B(1) 12628193 10 9 10 4 4 2 1 2 1 0 0.785 1.000 1.000 419 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 32 AKT1(3), BAD(1), CFLAR(1), IRS1(2), JAK1(2), JAK3(2), SHC1(1), STAT5A(1), STAT5B(1), SYK(2) 16441221 16 14 15 5 3 7 2 2 2 0 0.613 1.000 1.000 420 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AADAT(1), AASDHPPT(1), AASS(1), ACAT1(1), ALDH1A3(1), ALDH1B1(1), BBOX1(1), DOT1L(2), EHHADH(5), EHMT2(1), HSD17B4(1), NSD1(1), PLOD1(1), PLOD3(1), SETD1A(1), SETDB1(1), SHMT2(1) 28467156 22 19 22 9 6 4 2 4 6 0 0.832 1.000 1.000 421 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 64 APAF1(1), BAD(1), BCL2L11(1), BIRC2(1), BIRC5(1), CASP1(1), FAS(1), FASLG(1), IRF6(1), LTA(1), MAP2K4(2), MAPK10(1), NFKB1(2), NFKBIB(1), RELA(2), TNFRSF10B(1), TNFRSF21(1), TRAF2(1) 27360148 21 20 21 5 6 7 1 5 2 0 0.362 1.000 1.000 422 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 32 AKT1(3), DAG1(2), DRD2(1), EGFR(4), ITPKB(1), ITPR1(1), ITPR2(5), PIK3CB(2), PLCB1(3), SHC1(1), STAT3(3) 26818398 26 25 25 7 5 10 3 6 2 0 0.478 1.000 1.000 423 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ACACA(1), ACACB(1), ACAT1(1), ACSS1(2), ACSS2(1), ALDH1A3(1), ALDH1B1(1), EHHADH(5), SUCLG1(1) 19532573 14 12 14 7 5 2 1 3 3 0 0.933 1.000 1.000 424 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 16 CSF1R(2), RBL1(1), RBL2(2), SIN3B(2) 12349747 7 5 7 6 2 1 0 3 1 0 0.968 1.000 1.000 425 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1B(1), ADRA1D(2), ADRA2C(1), ADRB2(1), CHRM1(1), CHRM2(2), CHRM3(1), DRD2(1), DRD3(1), HTR1D(1), HTR5A(1), HTR6(1), HTR7(1) 12597329 15 14 15 7 4 7 1 2 1 0 0.769 1.000 1.000 426 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 70 ACACB(1), AKT1(3), CPT1B(1), CPT1C(1), G6PC2(1), IRS1(2), JAK1(2), JAK3(2), LEPR(1), MAPK10(1), MAPK9(1), NFKB1(2), NFKBIB(1), PCK2(1), PRKAA2(2), PRKAG1(2), PRKAG2(1), RELA(2), STAT3(3), TRAF2(1), TYK2(1) 40758096 32 27 31 7 8 5 3 13 3 0 0.335 1.000 1.000 427 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(1), DLG4(1), F2(1), PLD1(2) 13478352 5 5 5 8 3 0 1 0 1 0 0.999 1.000 1.000 428 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 38 ATF2(2), DAXX(1), MAP2K4(2), MAP3K7(1), MAP3K9(1), MAPKAPK5(1), MEF2C(1), PLA2G4A(1), RAC1(1), RPS6KA5(2), SHC1(1), STAT1(1), TGFBR1(1), TRAF2(1) 17725534 17 17 17 8 1 4 1 9 2 0 0.917 1.000 1.000 429 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 AGPAT2(1), AGPAT3(1), AGPAT4(1), CDS1(1), CHAT(2), CPT1B(1), DGKD(3), DGKQ(1), DGKZ(1), GNPAT(1), GPD1(1), PLA2G2A(1), PLA2G4A(1), PLCG2(1), PPAP2A(1) 24422789 18 17 18 5 0 5 2 6 5 0 0.605 1.000 1.000 430 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CREBBP(2), DUSP1(1), MAP3K7(1), NFKB1(2), RELA(2), TGFBR1(1) 14585889 9 8 9 6 3 2 0 3 1 0 0.968 1.000 1.000 431 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(2), ADCY3(1), ARF4(1), ARF5(1), ATP6V0A1(1), ATP6V0A2(3), ATP6V0D1(1), ATP6V1A(2), ATP6V1C2(3), PLCG2(1), PRKCA(1), SEC61A1(1), SEC61A2(1) 18175362 19 17 19 8 5 3 2 7 2 0 0.802 1.000 1.000 432 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(2), AMY2B(1), ENPP1(2), ENPP3(1), GAA(1), GANAB(1), GBE1(1), GCK(1), GPI(1), GYS1(1), HK2(1), HK3(1), MGAM(2), PGM3(1), PYGL(1), SI(2), UGT1A1(2), UGT1A3(1), UGT1A7(1), UGT2B15(3) 28039418 27 20 27 7 9 4 2 7 5 0 0.469 1.000 1.000 433 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 29 AKT1(3), APC(2), DACT1(2), DKK1(2), LRP1(1), PTPRA(1), WIF1(2) 19003087 13 12 12 6 1 5 1 4 2 0 0.894 1.000 1.000 434 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 42 AKT1(3), DDIT4(1), FIGF(1), PIK3CB(2), PIK3CD(2), PIK3CG(1), PIK3R2(1), PIK3R3(1), PRKAA2(2), RPS6KA3(1), RPS6KA6(1), RPS6KB2(1), TSC2(1) 24259528 18 18 17 5 0 7 1 6 4 0 0.582 1.000 1.000 435 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 250 ACVR1B(1), ACVR2A(1), BMPR1A(1), BMPR1B(1), BMPR2(1), CCL15(1), CCL28(1), CCL7(1), CCR1(1), CCR2(3), CCR4(1), CD40(1), CSF1R(2), CSF2RA(1), EGF(2), EGFR(4), FAS(1), FASLG(1), FLT1(1), FLT3(1), GH1(1), GH2(1), GHR(2), HGF(3), IFNA10(1), IFNA13(1), IFNA16(2), IFNA17(1), IFNA21(1), IFNA6(1), IFNB1(1), IL10RA(1), IL12A(1), IL12RB2(1), IL13RA1(1), IL17RA(1), IL17RB(1), IL20(1), IL21(1), IL22(1), IL23A(1), IL3RA(1), IL4R(3), IL5RA(1), IL6ST(3), IL7(1), IL7R(1), IL9(1), INHBA(2), INHBE(1), KDR(4), LEPR(1), LIF(1), LIFR(3), LTA(1), LTBR(2), MET(3), PRLR(2), TGFBR1(1), TNFRSF10A(1), TNFRSF10B(1), TNFRSF11B(1), TNFRSF13B(2), TNFRSF18(1), TNFRSF19(1), TNFRSF21(1), TNFRSF4(1), TNFRSF6B(1), TNFRSF8(1), TNFSF14(1), TNFSF15(1), TPO(1), XCL1(1), XCR1(1) 86988637 100 75 100 19 29 21 7 28 15 0 0.0403 1.000 1.000 436 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 ANKHD1(1), EEF2(1), EIF2AK3(4), EIF4E(1), EIF4G1(3), EIF5B(1) 21547485 11 11 11 8 1 2 1 5 2 0 0.988 1.000 1.000 437 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAS1(1), ALAS2(1), COX10(1), CP(3), EPRS(1), HMBS(1), UGT1A1(2), UGT1A3(1), UGT1A7(1), UGT2A3(1), UGT2B11(2), UGT2B15(3), UGT2B28(1), UGT2B7(1) 20745874 20 17 20 9 6 2 5 5 2 0 0.889 1.000 1.000 438 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(1), POLD3(1), POLE(3), POLG(1), POLG2(1), POLQ(1), PRIM2(1) 19947864 9 8 9 4 2 2 1 2 2 0 0.864 1.000 1.000 439 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2A1(1), GTF2B(1), GTF2E2(1), GTF2H3(1), GTF2I(1), TAF1(1), TAF13(1), TAF1L(5), TAF2(1), TAF4(1), TAF5(1), TAF5L(1), TAF6(2) 17734997 18 14 18 7 8 3 0 6 1 0 0.784 1.000 1.000 440 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 41 DAXX(1), EGF(2), EGFR(4), MAP2K4(2), NFKB1(2), PRKCA(1), PRKCG(1), RELA(2), SP1(2), TRAF2(1) 23908610 18 18 18 5 5 4 1 7 1 0 0.524 1.000 1.000 441 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(3), DUSP1(1), EIF4E(1), MAP2K4(2), MAP3K4(1), MAP3K7(1), MAPKAPK5(1), NFKB1(2) 16328832 12 12 11 5 2 5 1 3 1 0 0.832 1.000 1.000 442 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 44 INPP5B(2), INPP5E(2), INPPL1(1), IPMK(1), ITPKB(1), OCRL(1), PI4KA(1), PI4KB(1), PIK3CB(2), PIK3CD(2), PIK3CG(1), PIP4K2B(1), PIP5K1A(1), PLCB1(3), PLCE1(1), PLCG2(1), PLCZ1(1), SYNJ1(1), SYNJ2(2) 33853395 26 22 26 6 5 7 2 9 3 0 0.310 1.000 1.000 443 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 40 AKT1(3), CREBBP(2), DAG1(2), EGR1(1), FRS2(1), MAP2K4(2), MAPK10(1), MAPK9(1), NTRK1(1), PIK3CD(2), RPS6KA3(1), SHC1(1) 23304305 18 16 17 6 3 8 2 2 3 0 0.613 1.000 1.000 444 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA1(3), ACAA2(1), ADH4(1), ADHFE1(1), ALDH1A3(1), ALDH1B1(1), CYP7A1(1), SLC27A5(1) 15531660 10 9 10 5 2 1 0 6 1 0 0.868 1.000 1.000 445 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ARG2(1), CKB(1), CKMT1B(1), CKMT2(1), CPS1(2), DAO(1), EPRS(1), GLUD2(1), GOT2(1), NOS1(1), NOS3(2), P4HA1(1), P4HA2(2), P4HA3(2), PARS2(1), PYCR1(1) 17621763 20 17 20 8 7 7 2 3 1 0 0.706 1.000 1.000 446 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(1), AKT1(3), CHRM1(1), FLT1(1), KDR(4), NOS3(2), PDE3B(1), RYR2(7), SYT1(1), TNNI1(1) 19798558 22 19 21 7 8 6 5 1 2 0 0.637 1.000 1.000 447 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 37 AKT1(3), ATF2(2), DUSP4(1), DUSP8(1), GCK(1), MAP2K4(2), MAP3K12(3), MAP3K13(1), MAP3K3(1), MAP3K4(1), MAP3K7(1), MAP3K9(1), MAPK10(1), MAPK9(1), PAPPA(2), SHC1(1) 24382359 23 19 22 7 8 6 3 3 3 0 0.594 1.000 1.000 448 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 31 AKT1(3), BAD(1), BTK(1), INPP5D(1), PDK1(1), RPS6KA3(1), SHC1(1) 16292561 9 7 8 6 2 4 2 0 1 0 0.953 1.000 1.000 449 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSD(1), ARSE(1), GAL3ST1(1), LCT(1), NEU4(1), PPAP2A(1), SGMS1(1), SMPD2(2), SPTLC2(1) 17471896 10 9 10 6 2 2 1 4 1 0 0.921 1.000 1.000 450 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(1), ATP6V0A1(1), ATP6V0D1(1), ATP6V1A(2), ATP6V1B2(1), ATP6V1C2(3), ATP7A(1), ATP7B(2), COX10(1), COX7A1(1), NDUFA10(1), NDUFS2(1), SDHA(1), SDHB(1), UQCRC1(1), UQCRFS1(1) 18807063 20 16 20 7 8 4 4 3 1 0 0.659 1.000 1.000 451 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(3), ARHGEF11(2), DLG4(1), GNA13(1), MAP2K4(2), NFKB1(2), NFKBIB(1), PDK1(1), PIK3CB(2), PLD1(2), ROCK1(4), ROCK2(1) 24176880 22 21 20 6 5 5 3 6 3 0 0.527 1.000 1.000 452 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CD14(1), LY96(1), MAP2K4(2), MAP3K7(1), NFKB1(2), RELA(2) 17833754 9 9 9 4 2 3 0 3 1 0 0.834 1.000 1.000 453 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 27 CPEB1(1), EGFR(4), ERBB4(2), ETV6(1), ETV7(1), FMN2(2), NOTCH2(2), NOTCH4(2), PIWIL1(4), PIWIL2(1), PIWIL3(2) 24911267 22 21 22 7 6 4 4 5 3 0 0.714 1.000 1.000 454 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 33 ADCY1(1), NFATC2(1), NFATC4(1), PPP3CA(1), PPP3CC(1), PRKCA(1), RPS6KA3(1), SYT1(1) 16898193 8 6 8 4 4 0 1 2 1 0 0.858 1.000 1.000 455 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 61 APAF1(1), BAI1(2), CCNE2(1), CCNG1(1), CCNG2(1), FAS(1), GTSE1(1), MDM4(1), RCHY1(1), RRM2B(1), SERPINB5(1), SESN1(1), SESN2(1), SESN3(1), THBS1(1), TNFRSF10B(1), TSC2(1) 28209540 18 18 18 9 0 5 2 7 4 0 0.965 1.000 1.000 456 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 32 ACTA1(1), CRK(1), DOCK1(1), HGF(3), ITGA1(1), MET(3), STAT3(3) 19963984 13 13 13 7 2 1 2 7 1 0 0.934 1.000 1.000 457 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 34 ACTA1(1), BCR(1), CAPNS1(1), ITGA1(1), ROCK1(4), SHC1(1), TLN1(2) 22961109 11 10 10 5 0 1 2 6 2 0 0.886 1.000 1.000 458 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ADCY8(2), CACNA1A(2), CACNA1B(1), GNB3(1), PRKACA(1), SCNN1B(2), TAS2R4(1), TAS2R5(1), TAS2R60(2) 27920857 13 12 13 9 2 1 0 7 3 0 0.987 1.000 1.000 459 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 35 BTK(1), FCER1A(1), LYN(1), MAP2K4(2), NFATC2(1), NFATC4(1), PAK2(1), PLA2G4A(1), PPP3CA(1), PPP3CC(1), SHC1(1), SYK(2), SYT1(1) 19862897 15 12 15 7 6 4 1 3 1 0 0.870 1.000 1.000 460 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 88 ACVR1B(1), ACVR1C(1), ACVR2A(1), ACVRL1(1), BMP4(1), BMP6(1), BMPR1A(1), BMPR1B(1), BMPR2(1), COMP(1), CREBBP(2), DCN(1), FST(1), GDF6(1), INHBA(2), INHBE(1), LTBP1(3), PPP2R1B(1), PPP2R2B(3), PPP2R2C(1), RBL1(1), RBL2(2), ROCK1(4), ROCK2(1), RPS6KB2(1), SMAD2(1), SMAD3(1), SMAD4(4), SMAD6(1), SMAD9(1), SMURF2(1), SP1(2), TFDP1(1), TGFBR1(1), THBS1(1), THBS3(1), ZFYVE16(1), ZFYVE9(1) 48704950 52 45 51 11 8 14 5 20 5 0 0.218 1.000 1.000 461 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 57 APC(2), DVL3(1), FZD2(3), FZD5(1), FZD6(3), FZD7(1), FZD9(1), LDLR(1), MAPK10(1), MAPK9(1), PPP2R5E(2), PRKCA(1), PRKCG(1), PRKD1(1), RAC1(1), WNT2(1), WNT6(1) 28758732 23 21 23 9 4 9 1 6 3 0 0.749 1.000 1.000 462 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 B3GALT2(1), B3GALT4(1), B3GNT2(1), B3GNT3(1), B3GNT4(1), B4GALNT1(1), B4GALT2(1), B4GALT4(1), GBGT1(1), PIGA(1), PIGO(1), PIGT(1), ST3GAL1(1), ST3GAL6(1), ST6GALNAC4(1), ST6GALNAC5(1), ST8SIA5(1) 23853211 17 15 17 9 6 6 1 3 0 1 0.889 1.000 1.000 463 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(2), CREBBP(2), ERCC3(1), GRIP1(1), GTF2A1(1), HDAC3(2), HDAC6(2), MEF2C(1), NRIP1(2) 22398681 14 12 14 5 3 3 1 6 1 0 0.713 1.000 1.000 464 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 CARS(1), EPRS(1), GARS(1), HARS(1), LARS(1), LARS2(1), MARS(1), MARS2(1), PARS2(1), QARS(2), TARS2(1), VARS(1), VARS2(1) 26718219 14 13 14 6 6 3 0 4 1 0 0.824 1.000 1.000 465 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 CREBBP(2), DLL4(2), DTX1(1), DTX3L(1), DVL3(1), JAG1(1), JAG2(2), MAML1(1), MAML2(1), MAML3(3), MFNG(1), NOTCH2(2), NOTCH4(2), NUMB(1), NUMBL(1), RBPJ(1), SNW1(1) 33968062 24 18 24 9 8 6 0 7 3 0 0.715 1.000 1.000 466 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(3), CAPN3(1), CAPN5(1), CAPN6(1), CAPN7(1), CAPN9(1), CAPNS1(1), CAV3(1), CRK(1), DOCK1(1), GIT2(1), ITGA10(2), ITGA2(2), ITGA2B(1), ITGA3(1), ITGA4(1), ITGA6(1), ITGA8(2), ITGA9(2), ITGAD(2), ITGAL(2), ITGAM(1), ITGAV(1), ITGAX(3), ITGB2(1), ITGB4(1), ITGB5(1), ITGB6(2), MAPK10(1), MYLK2(3), PAK2(1), PAK6(2), PIK3R2(1), RAC1(1), RAC2(1), RAC3(1), ROCK1(4), ROCK2(1), SHC1(1), SORBS1(2), TLN1(2), TNS1(4), VAV2(2), VAV3(3) 65756261 69 58 67 15 9 24 10 18 8 0 0.132 1.000 1.000 467 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 42 ACTR3(1), AKT1(3), ARHGEF11(2), BTK(1), CFL1(1), CFL2(1), INPPL1(1), ITPR1(1), ITPR2(5), LIMK1(1), MYLK(3), MYLK2(3), PAK2(1), PAK6(2), PDK1(1), PIK3CD(2), PIK3CG(1), ROCK1(4), ROCK2(1), SAG(2), WASF1(1) 32995554 38 33 36 10 7 11 4 9 7 0 0.508 1.000 1.000 468 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 64 ADCY1(1), ADCY8(2), ATF4(1), CACNA1C(2), CAMK2D(1), CREBBP(2), GRIA1(3), GRIA2(1), GRIN1(1), GRIN2A(6), GRIN2B(5), GRM1(4), GRM5(1), ITPR1(1), ITPR2(5), PLCB1(3), PPP1CA(1), PPP3CA(1), PPP3CC(1), PRKACA(1), PRKCA(1), PRKCG(1), RPS6KA3(1), RPS6KA6(1) 46563027 47 45 47 12 8 11 8 13 7 0 0.473 1.000 1.000 469 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 162 ADORA3(2), ADRA1B(1), ADRA1D(2), ADRA2C(1), ADRB2(1), AGTR1(1), AVPR1A(3), AVPR1B(1), BRS3(1), CCKAR(1), CCKBR(1), CCR1(1), CCR2(3), CCR4(1), CCRL2(1), CHRM1(1), CHRM2(2), CHRM3(1), CMKLR1(1), CNR1(1), DRD2(1), DRD3(1), F2R(1), GPR17(1), GPR174(1), GPR37L1(3), GPR50(2), GPR83(2), GPR87(3), HCRTR2(2), HTR1D(1), HTR5A(1), HTR6(1), HTR7(1), LHCGR(1), MAS1(1), MC4R(1), MTNR1B(1), NMUR2(1), NPY1R(1), NPY2R(2), OPRL1(1), OR12D3(1), OR1F1(1), OR7A5(2), OXTR(1), P2RY10(1), PTAFR(1), SSTR1(2) 59718654 66 51 66 19 16 26 8 10 6 0 0.178 1.000 1.000 470 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 71 CACNA1A(2), GNA12(1), GNA13(1), GNAI2(1), GNAO1(1), GNAZ(1), GRIA1(3), GRIA2(1), GRIA3(1), GRID2(2), GRM1(4), GRM5(1), GUCY1A2(1), GUCY1A3(1), GUCY2C(1), GUCY2F(1), IGF1R(2), ITPR1(1), ITPR2(5), LYN(1), NOS1(1), NOS3(2), PLA2G2A(1), PLA2G4A(1), PLCB1(3), PPP2R1B(1), PPP2R2B(3), PPP2R2C(1), PRKCA(1), PRKCG(1), RYR1(2) 51845348 49 39 49 13 9 14 5 14 7 0 0.374 1.000 1.000 471 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 187 ACTG1(2), AKT1(3), ARHGAP5(2), BAD(1), BIRC2(1), CAV3(1), COL11A1(7), COL11A2(3), COL1A1(1), COL1A2(1), COL3A1(2), COL4A1(1), COL4A2(2), COL4A4(2), COL5A2(1), COL5A3(2), COL6A1(1), COL6A3(5), COL6A6(2), COMP(1), CRK(1), DOCK1(1), EGF(2), EGFR(4), FARP2(2), FIGF(1), FLNB(1), FLNC(2), FLT1(1), FN1(3), HGF(3), IGF1R(2), ITGA1(1), ITGA10(2), ITGA2(2), ITGA2B(1), ITGA3(1), ITGA4(1), ITGA6(1), ITGA8(2), ITGA9(2), ITGAV(1), ITGB4(1), ITGB5(1), ITGB6(2), KDR(4), LAMA1(2), LAMA2(4), LAMA4(1), LAMA5(2), LAMB1(4), LAMB3(1), LAMC1(3), LAMC2(3), MAPK10(1), MAPK9(1), MET(3), MYLK(3), MYLK2(3), PAK2(1), PAK6(2), PARVB(1), PARVG(1), PDGFD(1), PIK3CB(2), PIK3CD(2), PIK3CG(1), PIK3R2(1), PIK3R3(1), PPP1CA(1), PRKCA(1), PRKCG(1), RAC1(1), RAC2(1), RAC3(1), RELN(2), ROCK1(4), ROCK2(1), SHC1(1), SHC2(1), THBS1(1), THBS3(1), TLN1(2), TLN2(1), TNC(3), TNN(1), TNXB(5), VAV2(2), VAV3(3), VWF(5) 178903398 169 114 166 50 36 56 17 41 19 0 0.451 1.000 1.000 472 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 200 APC(2), ARHGEF1(2), ARPC4(1), ARPC5L(1), CD14(1), CFL1(1), CFL2(1), CHRM1(1), CHRM2(2), CHRM3(1), CRK(1), CYFIP1(1), CYFIP2(1), DIAPH3(1), DOCK1(1), EGF(2), EGFR(4), EZR(1), F2(1), F2R(1), FGD1(1), FGF10(1), FGF3(1), FGF4(1), FGF5(1), FGF7(1), FN1(3), GNA12(1), GNA13(1), IQGAP1(3), IQGAP2(1), ITGA1(1), ITGA10(2), ITGA2(2), ITGA2B(1), ITGA3(1), ITGA4(1), ITGA6(1), ITGA8(2), ITGA9(2), ITGAD(2), ITGAL(2), ITGAM(1), ITGAV(1), ITGAX(3), ITGB2(1), ITGB4(1), ITGB5(1), ITGB6(2), LIMK1(1), LIMK2(1), MSN(1), MYH10(3), MYH9(3), MYLK(3), MYLK2(3), NCKAP1L(1), PAK2(1), PAK6(2), PFN1(1), PFN2(2), PIK3CB(2), PIK3CD(2), PIK3CG(1), PIK3R2(1), PIK3R3(1), PIP4K2B(1), PIP5K1A(1), PPP1CA(1), RAC1(1), RAC2(1), RAC3(1), ROCK1(4), ROCK2(1), RRAS2(1), SLC9A1(1), SSH1(1), SSH2(6), SSH3(2), TIAM1(1), TIAM2(1), VAV2(2), VAV3(3), WAS(1), WASF1(1), WASF2(1) 133443453 130 96 129 34 26 36 17 33 18 0 0.226 1.000 1.000 473 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 167 ADCY1(1), ADCY2(1), ADCY3(1), ADCY7(1), ADCY8(2), ADRA1B(1), ADRA1D(2), ADRB2(1), AGTR1(1), ATP2A2(2), ATP2B1(1), ATP2B2(3), ATP2B4(3), AVPR1A(3), AVPR1B(1), CACNA1A(2), CACNA1B(1), CACNA1C(2), CACNA1D(1), CACNA1E(6), CACNA1S(2), CAMK2D(1), CCKAR(1), CCKBR(1), CHRM1(1), CHRM2(2), CHRM3(1), CYSLTR1(1), EGFR(4), ERBB3(2), ERBB4(2), F2R(1), GRIN1(1), GRIN2A(6), GRM1(4), GRM5(1), HTR5A(1), HTR6(1), HTR7(1), ITPKB(1), ITPR1(1), ITPR2(5), LHCGR(1), MYLK(3), MYLK2(3), NOS1(1), NOS3(2), OXTR(1), P2RX2(1), P2RX5(1), PDE1B(1), PDE1C(1), PHKA1(1), PHKB(1), PLCB1(3), PLCE1(1), PLCG2(1), PLCZ1(1), PPP3CA(1), PPP3CC(1), PRKACA(1), PRKCA(1), PRKCG(1), PTAFR(1), RYR1(2), RYR2(7), RYR3(4), SLC8A1(2), TACR1(1), TACR3(3) 130452238 125 95 125 49 26 35 18 31 15 0 0.921 1.000 1.000 474 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 236 ADORA3(2), ADRA1B(1), ADRA2C(1), ADRB2(1), AGTR1(1), AVPR1A(3), AVPR1B(1), BRS3(1), CCKAR(1), CCKBR(1), CHRM1(1), CHRM2(2), CHRM3(1), CNR1(1), CYSLTR1(1), DRD2(1), DRD3(1), F2(1), F2R(1), GABBR2(1), GABRA4(1), GABRB1(2), GABRB2(1), GABRD(1), GABRE(2), GABRG1(2), GABRR2(1), GH1(1), GH2(1), GHR(2), GHRHR(1), GIPR(1), GLP1R(1), GLP2R(3), GLRA2(1), GLRB(1), GPR50(2), GPR83(2), GRIA1(3), GRIA2(1), GRIA3(1), GRIA4(2), GRID1(2), GRID2(2), GRIK1(1), GRIK3(3), GRIK4(2), GRIN1(1), GRIN2A(6), GRIN2B(5), GRIN3A(2), GRM1(4), GRM2(1), GRM5(1), GRM8(1), HCRTR2(2), HTR1D(1), HTR5A(1), HTR6(1), HTR7(1), LEPR(1), LHCGR(1), MAS1(1), MC4R(1), MTNR1B(1), NMUR2(1), NPY1R(1), NPY2R(2), OPRL1(1), OXTR(1), P2RX2(1), P2RX5(1), P2RY10(1), PRLR(2), PRSS3(1), PTAFR(1), PTH2R(2), RXFP1(1), SSTR1(2), TAAR1(1), TAAR2(1), TAAR6(1), TAAR8(1), TACR1(1), TACR3(3), TSHR(1), VIPR1(1) 109101381 127 90 127 36 31 38 20 25 13 0 0.194 1.000 1.000 475 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 244 ACVR1B(1), ACVR1C(1), AKT1(3), ATF2(2), ATF4(1), CACNA1A(2), CACNA1B(1), CACNA1C(2), CACNA1D(1), CACNA1E(6), CACNA1S(2), CACNA2D1(2), CACNA2D3(1), CACNB1(2), CACNB2(1), CACNB4(1), CACNG7(2), CD14(1), CRK(1), DAXX(1), DUSP1(1), DUSP16(1), DUSP4(1), DUSP7(1), DUSP8(1), DUSP9(1), EGF(2), EGFR(4), FAS(1), FASLG(1), FGF10(1), FGF3(1), FGF4(1), FGF5(1), FGF7(1), FLNB(1), FLNC(2), GNA12(1), MAP2K4(2), MAP3K12(3), MAP3K13(1), MAP3K3(1), MAP3K4(1), MAP3K6(1), MAP3K7(1), MAPK10(1), MAPK9(1), MAPKAPK3(1), MAPKAPK5(1), MEF2C(1), NF1(1), NFATC2(1), NFATC4(1), NFKB1(2), NTRK1(1), PAK2(1), PLA2G2A(1), PLA2G4A(1), PPM1A(1), PPP3CA(1), PPP3CC(1), PPP5C(1), PRKACA(1), PRKCA(1), PRKCG(1), PTPRR(1), RAC1(1), RAC2(1), RAC3(1), RAPGEF2(2), RASA2(1), RASGRF1(1), RASGRF2(2), RPS6KA3(1), RPS6KA5(2), RPS6KA6(1), RRAS2(1), STK4(1), TAOK1(1), TAOK2(1), TAOK3(1), TGFBR1(1), TRAF2(1) 138489753 109 86 108 39 29 24 9 31 16 0 0.797 1.000 1.000 476 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 ACTG1(2), COL11A1(7), COL11A2(3), COL17A1(2), COL1A1(1), COL1A2(1), COL3A1(2), COL4A1(1), COL4A2(2), COL4A4(2), COL5A2(1), COL5A3(2), COL6A1(1), COL6A3(5), COL6A6(2), COMP(1), DSC3(1), DSG1(1), DSG2(2), DSG4(1), FN1(3), GJB5(1), ITGA6(1), ITGB4(1), KRT12(1), KRT13(1), KRT14(1), KRT16(1), KRT18(1), KRT19(1), KRT23(1), KRT25(3), KRT27(3), KRT28(1), KRT5(1), KRT6C(3), KRT72(1), KRT73(1), KRT75(1), KRT78(2), KRT79(1), KRT83(1), KRT84(1), KRT85(1), KRT9(1), LAMA1(2), LAMA2(4), LAMA4(1), LAMA5(2), LAMB1(4), LAMB3(1), LAMC1(3), LAMC2(3), LMNA(1), NES(3), RELN(2), THBS1(1), THBS3(1), TNC(3), TNN(1), TNXB(5), VWF(5) 122045260 116 78 115 34 30 41 8 19 18 0 0.369 1.000 1.000 477 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 COL11A1(7), COL11A2(3), COL1A1(1), COL1A2(1), COL3A1(2), COL4A1(1), COL4A2(2), COL4A4(2), COL5A2(1), COL5A3(2), COL6A1(1), COL6A3(5), COL6A6(2), DAG1(2), FN1(3), FNDC1(2), FNDC3A(1), GP5(2), HSPG2(3), ITGA1(1), ITGA10(2), ITGA2(2), ITGA2B(1), ITGA3(1), ITGA4(1), ITGA6(1), ITGA8(2), ITGA9(2), ITGAV(1), ITGB4(1), ITGB5(1), ITGB6(2), LAMA1(2), LAMA2(4), LAMA4(1), LAMA5(2), LAMB1(4), LAMB3(1), LAMC1(3), LAMC2(3), RELN(2), SDC1(1), SV2A(1), SV2B(1), THBS1(1), THBS3(1), TNC(3), TNN(1), TNXB(5), VWF(5) 109787461 102 71 101 30 24 34 11 21 12 0 0.483 1.000 1.000 478 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 126 ABL1(1), CFL1(1), CFL2(1), DPYSL2(1), EFNA3(1), EFNA5(1), EPHA3(5), EPHA4(1), EPHA5(1), EPHA6(2), EPHA7(1), EPHB1(2), EPHB3(1), FES(3), GNAI2(1), L1CAM(2), LIMK1(1), LIMK2(1), LRRC4C(1), MET(3), NFATC2(1), NFATC4(1), NRP1(1), NTNG1(2), PAK2(1), PAK6(2), PLXNA1(1), PLXNA2(2), PLXNB1(1), PLXNB2(1), PLXNC1(3), PPP3CA(1), PPP3CC(1), RAC1(1), RAC2(1), RAC3(1), ROBO1(4), ROBO2(3), ROBO3(1), ROCK1(4), ROCK2(1), SEMA3A(1), SEMA3D(1), SEMA3E(2), SEMA3F(1), SEMA4C(3), SEMA6A(1), SEMA6C(1), SEMA6D(2), SLIT1(2), SLIT3(2), SRGAP1(2), SRGAP3(2), UNC5A(1), UNC5B(1), UNC5D(1) 96377736 88 65 87 30 18 24 11 24 11 0 0.724 1.000 1.000 479 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 128 ACTG1(2), AKT1(3), ASH1L(7), CLDN20(1), CLDN9(1), CSNK2A1(1), CSNK2A2(1), CTNNA1(1), CTNNA2(1), EPB41L1(1), EPB41L2(1), EPB41L3(3), EXOC4(2), GNAI2(1), INADL(2), MAGI1(1), MAGI2(1), MLLT4(2), MPDZ(3), MYH1(3), MYH10(3), MYH11(1), MYH13(1), MYH15(1), MYH4(5), MYH6(5), MYH7(1), MYH7B(1), MYH8(4), MYH9(3), PPP2R1B(1), PPP2R2B(3), PPP2R2C(1), PPP2R3A(1), PPP2R3B(1), PPP2R4(1), PRKCA(1), PRKCG(1), RAB13(1), RRAS2(1), SPTAN1(1), TJP1(2), TJP2(2), TJP3(1), VAPA(2), YES1(1) 94095492 84 63 83 23 16 26 9 20 13 0 0.339 1.000 1.000 480 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(1), ADCY2(1), ADCY3(1), ADCY7(1), ADCY8(2), ADRA1B(1), ADRA1D(2), ADRB2(1), ANXA6(2), ATP2A2(2), ATP2B1(1), ATP2B2(3), CACNA1A(2), CACNA1B(1), CACNA1C(2), CACNA1D(1), CACNA1E(6), CACNA1S(2), CACNB1(2), CAMK1(1), CAMK2D(1), CHRM1(1), CHRM2(2), CHRM3(1), GJB5(1), GNAI2(1), GNAO1(1), GNAZ(1), GNB3(1), GNB5(2), ITPR1(1), ITPR2(5), MIB1(1), PRKACA(1), PRKCA(1), PRKCG(1), PRKD1(1), RGS10(1), RGS9(1), RYR1(2), RYR2(7), RYR3(4), SLC8A1(2) 91863727 75 60 75 39 10 21 12 19 13 0 0.999 1.000 1.000 481 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 141 APC(2), CACYBP(1), CAMK2D(1), CREBBP(2), CSNK2A1(1), CSNK2A2(1), DAAM1(2), DAAM2(1), DKK1(2), DVL3(1), FBXW11(2), FZD2(3), FZD4(2), FZD5(1), FZD6(3), FZD7(1), FZD9(1), LEF1(1), MAP3K7(1), MAPK10(1), MAPK9(1), NFATC2(1), NFATC4(1), PLCB1(3), PPP2R1B(1), PPP2R2B(3), PPP2R2C(1), PPP3CA(1), PPP3CC(1), PRICKLE2(1), PRKACA(1), PRKCA(1), PRKCG(1), RAC1(1), RAC2(1), RAC3(1), ROCK1(4), ROCK2(1), SFRP2(1), SMAD2(1), SMAD3(1), SMAD4(4), SOX17(1), TBL1XR1(2), TCF7L1(1), TCF7L2(1), WIF1(2), WNT2(1), WNT6(1), WNT9A(1) 77235371 72 58 71 32 12 22 6 20 12 0 0.974 1.000 1.000 482 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 130 ALCAM(1), CADM1(1), CD34(1), CD40(1), CD6(1), CD8A(1), CD8B(1), CDH1(2), CDH2(2), CDH3(2), CDH4(1), CDH5(4), CLDN20(1), CLDN9(1), CNTN2(1), CNTNAP1(4), CNTNAP2(1), HLA-DMB(1), HLA-DQA2(1), HLA-G(1), ICAM3(1), ITGA4(1), ITGA6(1), ITGA8(2), ITGA9(2), ITGAL(2), ITGAM(1), ITGAV(1), ITGB2(1), L1CAM(2), MAG(1), NCAM1(1), NCAM2(2), NEGR1(1), NEO1(1), NRCAM(2), NRXN1(1), NRXN2(1), NRXN3(2), PTPRC(3), PTPRM(1), PVRL1(1), PVRL2(1), SDC1(1), SELE(2), SELP(2), SIGLEC1(1), SPN(1), VCAM1(1), VCAN(4) 72339475 73 57 73 22 14 28 6 15 10 0 0.434 1.000 1.000 483 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 150 AKT1(3), CREBBP(2), CSF2RA(1), GH1(1), GH2(1), GHR(2), IFNA10(1), IFNA13(1), IFNA16(2), IFNA17(1), IFNA21(1), IFNA6(1), IFNB1(1), IL10RA(1), IL12A(1), IL12RB2(1), IL13RA1(1), IL20(1), IL21(1), IL22(1), IL23A(1), IL3RA(1), IL4R(3), IL5RA(1), IL6ST(3), IL7(1), IL7R(1), IL9(1), JAK1(2), JAK3(2), LEPR(1), LIF(1), LIFR(3), PIAS3(1), PIAS4(1), PIK3CB(2), PIK3CD(2), PIK3CG(1), PIK3R2(1), PIK3R3(1), PRLR(2), SOCS4(2), SPRY3(1), STAT1(1), STAT2(1), STAT3(3), STAT4(3), STAT5A(1), STAT5B(1), TPO(1), TYK2(1) 70470730 72 55 71 20 17 11 9 22 13 0 0.580 1.000 1.000 484 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA1(1), ADCY1(1), ADCY2(1), ADCY3(1), ADCY7(1), ADCY8(2), ATF2(2), ATF4(1), ATP2A2(2), CAMK2D(1), DGKZ(1), GBA2(1), GNB3(1), GNB5(2), GSTO1(1), GUCY1A3(1), IGFBP6(1), ITPR1(1), ITPR2(5), MIB1(1), MYLK2(3), NFKB1(2), NOS1(1), NOS3(2), OXTR(1), PLCG2(1), PRKACA(1), PRKCA(1), PRKD1(1), RGS10(1), RGS9(1), RYR1(2), RYR2(7), RYR3(4), SLC8A1(2), SP1(2), TNXB(5) 84868972 65 54 65 37 11 17 11 15 11 0 0.999 1.000 1.000 485 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 74 ACP1(1), ACTG1(2), ACVR1B(1), ACVR1C(1), CDH1(2), CREBBP(2), CSNK2A1(1), CSNK2A2(1), CTNNA1(1), CTNNA2(1), EGFR(4), FARP2(2), FER(3), IGF1R(2), INSR(1), IQGAP1(3), LEF1(1), LMO7(2), MAP3K7(1), MET(3), MLLT4(2), PTPRB(1), PTPRM(1), PVRL1(1), PVRL2(1), RAC1(1), RAC2(1), RAC3(1), SMAD2(1), SMAD3(1), SMAD4(4), SNAI1(1), SORBS1(2), SSX2IP(1), TCF7L1(1), TCF7L2(1), TGFBR1(1), TJP1(2), WAS(1), WASF1(1), WASF2(1), WASF3(1), YES1(1) 58122450 64 53 64 18 11 14 8 25 6 0 0.494 1.000 1.000 486 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 128 ACACA(1), ACACB(1), AKT1(3), BAD(1), CRK(1), FASN(1), G6PC2(1), GCK(1), GYS1(1), INPP5D(1), INSR(1), IRS1(2), MAPK10(1), MAPK9(1), PCK2(1), PDE3B(1), PFKL(2), PFKM(2), PFKP(2), PHKA1(1), PHKB(1), PIK3CB(2), PIK3CD(2), PIK3CG(1), PIK3R2(1), PIK3R3(1), PPP1CA(1), PPP1R3A(4), PPP1R3B(2), PRKAA2(2), PRKACA(1), PRKAG1(2), PRKAG2(1), PYGL(1), RPS6KB2(1), SHC1(1), SHC2(1), SOCS4(2), SORBS1(2), TRIP10(1), TSC2(1) 76462337 57 52 56 22 6 17 4 20 10 0 0.893 1.000 1.000 487 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(1), DMD(2), MYBPC2(2), MYBPC3(1), MYH6(5), MYH7(1), MYH8(4), MYL1(1), MYOM1(1), NEB(5), TNNI1(1), TPM4(1), TTN(43) 66721237 68 52 68 17 16 20 4 19 9 0 0.373 1.000 1.000 488 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 123 CD244(1), CD48(4), FAS(1), FASLG(1), HLA-G(1), IFNA10(1), IFNA13(1), IFNA16(2), IFNA17(1), IFNA21(1), IFNA6(1), IFNB1(1), ITGAL(2), ITGB2(1), KIR3DL1(2), LCP2(2), MICB(1), NCR1(2), NCR2(1), NFATC2(1), NFATC4(1), PIK3CB(2), PIK3CD(2), PIK3CG(1), PIK3R2(1), PIK3R3(1), PLCG2(1), PPP3CA(1), PPP3CC(1), PRKCA(1), PRKCG(1), RAC1(1), RAC2(1), RAC3(1), SH3BP2(1), SHC1(1), SHC2(1), SYK(2), TNFRSF10A(1), TNFRSF10B(1), ULBP3(1), VAV2(2), VAV3(3), ZAP70(2) 53652046 59 48 59 22 12 22 4 13 8 0 0.816 1.000 1.000 489 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 108 ARHGAP5(2), CDH5(4), CLDN20(1), CLDN9(1), CTNNA1(1), CTNNA2(1), CYBB(1), EZR(1), GNAI2(1), ITGA4(1), ITGAL(2), ITGAM(1), ITGB2(1), MLLT4(2), MMP2(1), MMP9(2), MSN(1), NCF2(1), PIK3CB(2), PIK3CD(2), PIK3CG(1), PIK3R2(1), PIK3R3(1), PLCG2(1), PRKCA(1), PRKCG(1), RAC1(1), RAC2(1), RAPGEF4(2), ROCK1(4), ROCK2(1), SIPA1(2), VAV2(2), VAV3(3), VCAM1(1) 59061866 52 47 51 20 6 18 5 15 8 0 0.849 1.000 1.000 490 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADA(1), ADCY1(1), ADCY2(1), ADCY3(1), ADCY7(1), ADCY8(2), AK7(1), AMPD1(3), AMPD2(2), APRT(1), ATIC(3), CANT1(1), DGUOK(1), ENPP1(2), ENPP3(1), ENTPD3(1), ENTPD6(1), ENTPD8(1), FHIT(1), GART(1), GUCY1A2(1), GUCY1A3(1), GUCY2C(1), GUCY2F(1), NME1(1), NT5E(1), PAPSS2(1), PDE10A(4), PDE1C(1), PDE3B(1), PDE8A(3), PDE9A(1), POLA1(1), POLD3(1), POLE(3), POLR1A(2), POLR1B(1), POLR1C(1), POLR2B(1), POLR3A(2), PRIM2(1), PRPS1L1(3), RRM1(3), RRM2B(1) 80285268 64 46 64 16 16 15 6 15 12 0 0.265 1.000 1.000 491 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 75 ABL1(1), ACTR3(1), AKT1(3), CRK(1), DOCK1(1), GRB7(2), ITGA1(1), ITGA10(2), ITGA2(2), ITGA3(1), ITGA4(1), ITGA6(1), ITGA8(2), ITGA9(2), MAP2K4(2), MAPK10(1), MAPK9(1), MYLK(3), MYLK2(3), PAK2(1), PAK6(2), PIK3CB(2), PLCG2(1), ROCK1(4), ROCK2(1), SHC1(1), TLN1(2), TLN2(1), WAS(1) 57904662 47 44 45 16 5 15 6 16 5 0 0.747 1.000 1.000 492 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(2), AMY2B(1), DDX23(1), DDX41(1), DDX47(3), DDX50(3), ENPP1(2), ENPP3(1), ERCC2(2), ERCC3(1), G6PC2(1), GAA(1), GBE1(1), GCK(1), GPI(1), GYS1(1), HK2(1), HK3(1), MGAM(2), MOV10L1(1), PGM3(1), PYGL(1), RAD54B(2), SETX(3), SI(2), SKIV2L2(3), SMARCA2(1), SMARCA5(3), UGT1A1(2), UGT1A3(1), UGT1A7(1), UGT2A3(1), UGT2B11(2), UGT2B15(3), UGT2B28(1), UGT2B7(1) 60923446 56 42 56 15 12 9 7 22 6 0 0.462 1.000 1.000 493 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 67 C1S(2), C3(1), C4BPA(1), C6(4), C9(2), CD46(3), CFB(1), CFH(3), CR1(1), F11(3), F13A1(1), F13B(3), F2(1), F2R(1), F3(1), F5(4), F8(3), FGA(4), FGB(1), MASP1(1), MASP2(1), PLAT(1), PLG(2), PROC(1), PROS1(2), SERPIND1(1), VWF(5) 44457614 54 42 54 19 15 13 4 16 6 0 0.799 1.000 1.000 494 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADA(1), ADCY1(1), ADCY2(1), ADCY3(1), ADCY7(1), ADCY8(2), AMPD1(3), AMPD2(2), APRT(1), ATIC(3), ATP5A1(2), ATP5J(1), CANT1(1), DGUOK(1), ENPP1(2), ENPP3(1), FHIT(1), GART(1), GUCY1A2(1), GUCY1A3(1), GUCY2C(1), GUCY2F(1), NME1(1), NT5E(1), PAPSS2(1), PDE6C(1), PDE8A(3), PDE9A(1), POLE(3), POLG(1), POLQ(1), POLR1B(1), POLR2B(1), PRPS1L1(3), RRM1(3) 63057677 51 42 51 16 11 13 4 14 9 0 0.633 1.000 1.000 495 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 107 ALG12(1), ALG14(1), B3GNT2(1), B4GALT2(1), B4GALT4(1), CHPF(1), CHST12(1), CHSY1(1), DPAGT1(1), EXT1(1), EXT2(4), EXTL1(1), EXTL3(1), FUT8(1), GALNT10(1), GALNT11(1), GALNT13(1), GALNT14(1), GALNT3(1), GALNT4(1), GALNT8(1), GALNTL5(1), GANAB(1), HS6ST1(1), HS6ST2(1), MAN1A2(1), MAN2A1(3), MGAT5(1), MGAT5B(1), NDST2(2), NDST4(4), OGT(1), ST3GAL1(1), ST6GAL1(2), ST6GALNAC1(1), WBSCR17(1), XYLT1(2) 53893162 48 41 48 17 11 14 1 13 9 0 0.751 1.000 1.000 496 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 90 ADCY1(1), ADCY2(1), ADCY3(1), ADCY7(1), ADCY8(2), DRD2(1), EGF(2), EGFR(4), GNAI2(1), GRM1(4), GRM5(1), GUCY1A2(1), GUCY1A3(1), GUCY2C(1), GUCY2F(1), ITPR1(1), ITPR2(5), PDGFD(1), PLCB1(3), PRKACA(1), PRKCA(1), PRKCG(1), TJP1(2), TUBA1C(1), TUBA3C(3), TUBB1(1), TUBB2B(1), TUBB8(1) 63605089 45 40 45 17 9 13 6 11 6 0 0.787 1.000 1.000 497 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 91 ADCY1(1), ADCY2(1), ADCY3(1), ADCY7(1), ADCY8(2), AKAP1(1), AKAP11(1), AKAP12(1), AKAP2(3), AKAP3(1), AKAP6(2), AKAP8(1), AKAP9(2), ARHGEF1(2), GNA12(1), GNA13(1), GNAI2(1), GNAO1(1), GNAZ(1), GNB3(1), GNB5(2), ITPR1(1), PDE1B(1), PDE1C(1), PDE8A(3), PPP3CA(1), PPP3CC(1), PRKACA(1), PRKCA(1), PRKCG(1), PRKD1(1), PRKD3(2), SLC9A1(1) 57331390 43 38 43 13 8 10 5 14 6 0 0.640 1.000 1.000 498 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 70 CDS1(1), DGKD(3), DGKI(4), DGKQ(1), DGKZ(1), INPP5B(2), INPP5D(1), INPP5E(2), INPPL1(1), ITPKB(1), ITPR1(1), ITPR2(5), OCRL(1), PI4KA(1), PI4KB(1), PIK3C2A(1), PIK3CB(2), PIK3CD(2), PIK3CG(1), PIK3R2(1), PIK3R3(1), PIP4K2B(1), PIP5K1A(1), PLCB1(3), PLCE1(1), PLCG2(1), PLCZ1(1), PRKCA(1), PRKCG(1), SYNJ1(1), SYNJ2(2) 58483112 47 38 47 12 7 13 5 13 9 0 0.384 1.000 1.000 499 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 81 ABL1(1), AKT1(3), BAD(1), CAMK2D(1), CRK(1), EGF(2), EGFR(4), ERBB3(2), ERBB4(2), MAP2K4(2), MAPK10(1), MAPK9(1), NRG2(1), PAK2(1), PAK6(2), PIK3CB(2), PIK3CD(2), PIK3CG(1), PIK3R2(1), PIK3R3(1), PLCG2(1), PRKCA(1), PRKCG(1), RPS6KB2(1), SHC1(1), SHC2(1), STAT5A(1), STAT5B(1) 48234681 40 37 39 15 8 12 3 14 3 0 0.764 1.000 1.000 500 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 106 ABL1(1), ANAPC1(2), ANAPC2(1), ANAPC4(1), ANAPC5(1), ANAPC7(1), BUB1(1), BUB1B(1), CCNE2(1), CCNH(1), CDC14B(1), CDC16(1), CDC20(2), CDC27(1), CDC6(1), CDC7(2), CREBBP(2), E2F3(1), ESPL1(1), FZR1(1), MCM2(1), MCM3(1), MCM4(1), MCM5(1), MCM6(1), MCM7(1), PLK1(1), PRKDC(3), RB1(2), RBL1(1), RBL2(2), SMAD2(1), SMAD3(1), SMAD4(4), TFDP1(1) 63099221 46 37 46 15 10 6 5 21 4 0 0.772 1.000 1.000 501 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 93 ADCY1(1), ADCY2(1), ADCY3(1), ADCY7(1), ADCY8(2), ATF4(1), CACNA1C(2), CACNA1D(1), CACNA1S(2), CAMK2D(1), EGFR(4), ITPR1(1), ITPR2(5), MAP2K4(2), MAP3K3(1), MAP3K4(1), MAPK10(1), MAPK9(1), MMP2(1), PLA2G2A(1), PLA2G4A(1), PLCB1(3), PLD1(2), PRKACA(1), PRKCA(1) 60659944 39 37 39 21 10 9 4 10 6 0 0.983 1.000 1.000 502 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 83 ANPEP(1), CD14(1), CD1B(1), CD1C(2), CD34(1), CD37(1), CD8A(1), CD8B(1), CR1(1), CSF1R(2), CSF2RA(1), DNTT(1), FCER2(1), FCGR1A(1), FLT3(1), GP5(2), IL3RA(1), IL4R(3), IL5RA(1), IL7(1), IL7R(1), ITGA1(1), ITGA2(2), ITGA2B(1), ITGA3(1), ITGA4(1), ITGA6(1), ITGAM(1), MME(2), TPO(1) 40052947 37 35 37 18 5 10 8 8 6 0 0.979 1.000 1.000 503 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(2), ABCA10(1), ABCA12(1), ABCA13(4), ABCA3(1), ABCA4(4), ABCA5(5), ABCA7(3), ABCA8(1), ABCA9(2), ABCB11(2), ABCB5(1), ABCB6(1), ABCB7(1), ABCC10(2), ABCC11(1), ABCC12(1), ABCC4(1), ABCC5(2), ABCC8(1), ABCC9(2), ABCD3(1), ABCG1(1), ABCG8(1) 57980435 42 34 42 21 7 15 4 8 8 0 0.963 1.000 1.000 504 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 97 AKT1(3), CD14(1), CD40(1), IFNA10(1), IFNA13(1), IFNA16(2), IFNA17(1), IFNA21(1), IFNA6(1), IFNB1(1), IL12A(1), LY96(1), MAP2K4(2), MAP3K7(1), MAPK10(1), MAPK9(1), NFKB1(2), PIK3CB(2), PIK3CD(2), PIK3CG(1), PIK3R2(1), PIK3R3(1), RAC1(1), RELA(2), STAT1(1), TBK1(1), TLR5(1), TLR8(1) 43071631 36 34 35 16 7 8 1 12 8 0 0.952 1.000 1.000 505 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 72 AKT1(3), BTK(1), FCER1A(1), GAB2(3), INPP5D(1), LCP2(2), LYN(1), MAP2K4(2), MAPK10(1), MAPK9(1), PDK1(1), PIK3CB(2), PIK3CD(2), PIK3CG(1), PIK3R2(1), PIK3R3(1), PLA2G2A(1), PLA2G4A(1), PLCG2(1), PRKCA(1), RAC1(1), RAC2(1), RAC3(1), SYK(2), VAV2(2), VAV3(3) 34196510 38 34 37 14 7 14 4 9 4 0 0.756 1.000 1.000 506 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 ASH1L(7), DOT1L(2), EED(1), EHMT2(1), EZH1(2), HCFC1(1), JMJD4(1), KDM6A(6), MEN1(2), NSD1(1), OGT(1), PAXIP1(1), PPP1CA(1), PRDM2(2), PRDM9(1), PRMT1(1), PRMT5(2), RBBP5(1), SETD1A(1), SETD2(3), SETDB1(1), STK38(1), WHSC1L1(1) 58271677 41 33 41 10 7 8 3 10 13 0 0.577 1.000 1.000 507 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 96 ADCY1(1), ADCY2(1), ADCY3(1), ADCY7(1), ADCY8(2), CAMK2D(1), CREB3L2(1), CREB3L3(1), CREBBP(2), DVL3(1), FZD2(3), FZD4(2), FZD5(1), FZD6(3), FZD7(1), FZD9(1), GNAI2(1), GNAO1(1), LEF1(1), PLCB1(3), PRKACA(1), PRKCA(1), PRKCG(1), TCF7L1(1), TCF7L2(1), TYRP1(2), WNT2(1), WNT6(1), WNT9A(1) 51331139 39 33 39 21 7 18 2 8 4 0 0.970 1.000 1.000 508 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 80 ABL1(1), BUB1(1), BUB1B(1), CCNE2(1), CCNH(1), CDC14B(1), CDC20(2), CDC6(1), CDC7(2), CDH1(2), E2F3(1), ESPL1(1), HDAC3(2), HDAC6(2), HDAC8(1), MCM2(1), MCM3(1), MCM4(1), MCM5(1), MCM6(1), MCM7(1), MPEG1(1), PLK1(1), PRKDC(3), PTPRA(1), RB1(2), RBL1(1), SMAD4(4), TFDP1(1) 50310023 40 32 40 12 9 9 4 17 1 0 0.581 1.000 1.000 509 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 60 AKT1(3), BTK(1), CARD11(2), CD72(1), CD81(1), FCGR2B(1), INPP5D(1), LYN(1), NFATC2(1), NFATC4(1), NFKB1(2), NFKBIB(1), PIK3CB(2), PIK3CD(2), PIK3CG(1), PIK3R2(1), PIK3R3(1), PLCG2(1), PPP3CA(1), PPP3CC(1), RAC1(1), RAC2(1), RAC3(1), SYK(2), VAV2(2), VAV3(3) 35304926 36 32 35 18 9 12 3 8 4 0 0.949 1.000 1.000 510 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 90 AKT1(3), CARD11(2), CD8A(1), CD8B(1), LCP2(2), NFATC2(1), NFATC4(1), NFKB1(2), NFKBIB(1), PAK2(1), PAK6(2), PDK1(1), PIK3CB(2), PIK3CD(2), PIK3CG(1), PIK3R2(1), PIK3R3(1), PPP3CA(1), PPP3CC(1), PTPRC(3), VAV2(2), VAV3(3), ZAP70(2) 48669865 37 31 36 20 8 11 4 10 4 0 0.983 1.000 1.000 511 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 91 BAD(1), CNR1(1), CREBBP(2), CSNK2A1(1), FCER1A(1), IFNB1(1), KPNA5(1), MAPK9(1), NFATC2(1), NFATC4(1), NFKBIB(1), NPPB(1), NUP214(1), PPP3CC(1), PTPRC(3), RELA(2), SP1(2), SP3(3), TRAF2(1), TRPV6(1), VAV2(2), VAV3(3), XPO5(3) 44574613 35 30 34 21 11 8 3 9 4 0 0.992 1.000 1.000 512 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 53 ADORA3(2), CCKBR(1), CCR2(3), CELSR2(2), CHRM2(2), CHRM3(1), EMR2(3), EMR3(1), F2R(1), GHRHR(1), GPR116(1), GPR132(1), GPR133(1), GPR17(1), GPR55(1), GPR84(3), GRM1(4), LPHN2(1), LPHN3(4), TSHR(1) 32697889 35 30 34 14 9 11 3 12 0 0 0.662 1.000 1.000 513 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 82 ATF2(2), DAXX(1), MAP2K4(2), MAP3K12(3), MAP3K13(1), MAP3K3(1), MAP3K4(1), MAP3K6(1), MAP3K7(1), MAP3K9(1), MAPK10(1), MAPK9(1), MAPKAPK3(1), MAPKAPK5(1), MEF2C(1), NFKB1(2), PAK2(1), RAC1(1), RELA(2), RPS6KA3(1), RPS6KA5(2), RPS6KB2(1), SHC1(1), SP1(2), STAT1(1), TGFBR1(1), TRAF2(1) 45630610 35 30 35 12 8 8 2 12 5 0 0.698 1.000 1.000 514 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 77 AKT1(3), APAF1(1), BAD(1), BIRC2(1), CFLAR(1), FAS(1), FASLG(1), IL3RA(1), IRAK2(1), NFKB1(2), NTRK1(1), PIK3CB(2), PIK3CD(2), PIK3CG(1), PIK3R2(1), PIK3R3(1), PPP3CA(1), PPP3CC(1), PRKACA(1), RELA(2), TNFRSF10A(1), TNFRSF10B(1), TRAF2(1) 36376136 29 29 28 12 5 10 2 8 4 0 0.884 1.000 1.000 515 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 67 AKT1(3), BAD(1), KDR(4), MAPKAPK3(1), NFATC2(1), NFATC4(1), NOS3(2), PIK3CB(2), PIK3CD(2), PIK3CG(1), PIK3R2(1), PIK3R3(1), PLA2G2A(1), PLA2G4A(1), PLCG2(1), PPP3CA(1), PPP3CC(1), PRKCA(1), PRKCG(1), PTGS2(2), RAC1(1), RAC2(1), RAC3(1), SH2D2A(1), SHC2(1) 34057313 34 29 33 10 9 12 2 7 4 0 0.425 1.000 1.000 516 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 65 ADAM10(2), ATP6V0A1(1), ATP6V0A2(3), ATP6V0D1(1), ATP6V1A(2), ATP6V1B2(1), ATP6V1C2(3), EGFR(4), LYN(1), MAP2K4(2), MAPK10(1), MAPK9(1), MET(3), NFKB1(2), NOD1(1), PLCG2(1), RAC1(1), RELA(2), TCIRG1(1), TJP1(2) 34534831 35 28 35 14 12 5 4 11 3 0 0.804 1.000 1.000 517 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 91 CDC40(1), CLK2(1), CLK3(2), CPSF2(1), CPSF4(1), CSTF2T(1), CSTF3(1), DDX1(1), DHX16(1), DHX9(1), DNAJC8(1), METTL3(3), NXF1(1), PABPN1(1), PPM1G(2), PRPF3(1), PRPF8(1), RBM17(1), RBM5(1), RNMT(1), SF3A1(1), SF3A3(1), SF3B1(1), SNRPA(1), SNRPA1(1), SNRPN(1), SUPT5H(1) 51500545 31 28 31 13 6 8 1 12 4 0 0.885 1.000 1.000 518 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 45 AKT1(3), BAD(1), BCR(1), BTK(1), CD81(1), DAG1(2), INPP5D(1), ITPR1(1), ITPR2(5), LYN(1), NFATC2(1), PDK1(1), PIK3CD(2), PLCG2(1), PPP3CA(1), PPP3CC(1), PTPRC(3), SHC1(1), SYK(2) 35325829 30 28 29 15 5 10 4 7 4 0 0.965 1.000 1.000 519 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG1(2), ACTR3(1), AKT1(3), CFL1(1), CFL2(1), FLNC(2), FSCN2(1), FSCN3(1), LIMK1(1), MYLK(3), MYLK2(3), PAK2(1), PAK6(2), PFN1(1), PFN2(2), ROCK1(4), ROCK2(1), WASF1(1) 23497005 31 28 29 10 4 12 5 7 3 0 0.712 1.000 1.000 520 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 ACAT1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), AOC2(2), AOX1(2), CYP19A1(1), CYP1A1(1), CYP2A13(2), CYP2A6(1), CYP2B6(2), CYP2C19(2), CYP2C8(2), CYP2J2(1), DDC(1), EHHADH(5), KYNU(2), MAOA(1), TPH1(1) 27083187 32 28 32 10 5 7 4 8 8 0 0.679 1.000 1.000 521 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(1), ATP5A1(2), ATP5J(1), ATP6V0A1(1), ATP6V0A2(3), ATP6V0D1(1), ATP6V1A(2), ATP6V1B2(1), ATP6V1C2(3), COX10(1), COX7A1(1), CYC1(1), NDUFA10(1), NDUFA13(1), NDUFB9(1), NDUFS2(1), SDHA(1), SDHB(1), SDHC(2), TCIRG1(1), UQCRC1(1), UQCRFS1(1) 27417503 29 26 29 12 6 5 4 8 6 0 0.881 1.000 1.000 522 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AADAT(1), ACAT1(1), ALDH1A3(1), ALDH1B1(1), AOC2(2), AOX1(2), CYP1A1(1), DDC(1), EHHADH(5), HEMK1(1), HSD17B4(1), KYNU(2), LNX1(1), MAOA(1), METTL6(1), NFX1(1), PRMT3(2), PRMT5(2), TPH1(1) 29749010 28 26 28 12 6 3 2 5 12 0 0.909 1.000 1.000 523 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPP(2), DDX23(1), DDX41(1), DDX47(3), DDX50(3), DHFR(1), ERCC2(2), ERCC3(1), MOV10L1(1), RAD54B(2), SETX(3), SKIV2L2(3), SMARCA2(1), SMARCA5(3), SPR(1) 30924163 28 26 28 11 2 8 3 12 3 0 0.861 1.000 1.000 524 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F11(3), F13B(3), F2(1), F5(4), F8(3), FGA(4), FGB(1), PLAT(1), PLG(2), SERPINB2(1), VWF(5) 17327633 28 24 28 10 9 6 4 6 3 0 0.802 1.000 1.000 525 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 61 CCNE2(1), CCNG2(1), CCNH(1), CREB3L3(1), E2F3(1), GBA2(1), MCM2(1), MCM3(1), MCM4(1), MCM5(1), MCM6(1), MCM7(1), MYT1(1), NACA(1), POLE(3), RB1(2), RBL1(1), RPA1(1), RPA2(1), TFDP1(1), TFDP2(1), TNXB(5) 34312284 29 23 29 10 9 9 1 10 0 0 0.593 1.000 1.000 526 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(3), B3GALT4(1), CDR1(1), DGKI(4), IL6ST(3), RPL11(2), RPL28(1), RPL5(1), RPL7(1), RPS10(1), RPS6KA3(1), RPS6KA6(1), RPS6KB2(1), UBB(1), UBC(1) 25784014 23 21 23 11 5 5 2 3 8 0 0.959 1.000 1.000 527 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), AMD1(1), AOC2(2), ARG2(1), CKB(1), CKMT1B(1), CKMT2(1), CPS1(2), DAO(1), GOT2(1), MAOA(1), NOS1(1), NOS3(2), P4HA1(1), P4HA2(2), P4HA3(2), PYCR1(1) 21659262 26 20 26 10 10 7 3 4 2 0 0.721 1.000 1.000 528 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 31 AKT1(3), BCR(1), BTK(1), ITPR1(1), ITPR2(5), LYN(1), PDK1(1), PLCG2(1), PTPRC(3), RPS6KA3(1), SAG(2), SYK(2) 25685730 22 19 21 14 3 7 2 6 4 0 0.992 1.000 1.000 529 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ALDH1A3(1), ALDH1B1(1), AMDHD1(1), AOC2(2), ASPA(1), CNDP1(1), DDC(1), FTCD(1), HAL(1), HARS(1), HDC(1), HEMK1(1), MAOA(1), METTL6(1), PRMT3(2), PRMT5(2), UROC1(2) 19427958 21 18 21 10 5 5 1 2 8 0 0.907 1.000 1.000 530 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 60 AKT1(3), BAD(1), EBP(1), ERBB4(2), INPPL1(1), IRS1(2), MET(3), PAK2(1), PAK6(2), PDK1(1), PIK3CD(2), RPS6KA3(1), SHC1(1), TSC2(1) 36377991 22 18 21 11 5 6 2 5 4 0 0.929 1.000 1.000 531 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ACAA1(3), ACAA2(1), ACAT1(1), ALDH1A3(1), ALDH1B1(1), AOX1(2), BCKDHA(1), EHHADH(5), HMGCL(2), HMGCS1(2), HSD17B4(1), IVD(1) 21173407 21 17 21 10 4 2 2 5 8 0 0.932 1.000 1.000 532 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 38 AKT1(3), BAD(1), BCR(1), BTK(1), DAG1(2), ITPKB(1), LYN(1), NFKB1(2), NFKBIB(1), PIK3CD(2), PLCG2(1), SHC1(1), SYK(2) 24860432 19 17 18 11 5 9 2 2 1 0 0.945 1.000 1.000 533 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 40 MAP2K4(2), NFATC2(1), NFATC4(1), NFKB1(2), PPP3CA(1), PPP3CC(1), PRKCA(1), RAC1(1), RELA(2), SHC1(1), SYT1(1), ZAP70(2) 22207958 16 15 16 7 5 5 1 5 0 0 0.825 1.000 1.000 534 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 DAG1(2), ITPKB(1), LCP2(2), NFKB1(2), NFKBIB(1), PAK2(1), PAK6(2), PTPRC(3), ZAP70(2) 27454769 16 14 16 10 5 7 1 3 0 0 0.967 1.000 1.000 535 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 49 ACTA1(1), AKT1(3), CAMK1(1), CREBBP(2), F2(1), LIF(1), MEF2C(1), NFATC2(1), NFATC4(1), PPP3CA(1), PPP3CC(1), SYT1(1) 23735160 15 13 14 7 6 2 3 4 0 0 0.863 1.000 1.000 536 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 23 ATF2(2), BCR(1), LYN(1), PAPPA(2), RAC1(1), RPS6KA3(1), SHC1(1), SYK(2), VAV2(2), VAV3(3) 15503746 16 13 16 10 3 4 2 5 2 0 0.975 1.000 1.000 537 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(1), C6(4), ITGA4(1), ITGAL(2), ITGB2(1), SELP(2), VCAM1(1) 12217529 12 12 12 7 3 6 1 2 0 0 0.949 1.000 1.000 538 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 36 CAMK2D(1), F2(1), MYLK(3), PRKCA(1), SHC1(1), STAT1(1), STAT3(3), STAT5A(1), SYT1(1) 20278370 13 11 13 5 5 2 1 5 0 0 0.768 1.000 1.000 539 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 F13A1(1), F2(1), F2R(1), FGA(4), FGB(1), PLAT(1), PLG(2), SERPINB2(1) 6598800 12 11 12 5 3 3 2 4 0 0 0.843 1.000 1.000 540 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(1), ACACB(1), ACAT1(1), ACSS1(2), ACSS2(1), ALDH1A3(1), ALDH1B1(1), ME3(1), PC(1), PCK2(1) 23001149 11 11 11 5 3 1 2 5 0 0 0.860 1.000 1.000 541 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 CCNH(1), ERCC3(1), GTF2B(1), GTF2E2(1), POLR1A(2), POLR1B(1), POLR2B(1), TAF13(1), TAF5(1), TAF6(2) 17230596 12 11 12 7 4 1 2 5 0 0 0.957 1.000 1.000 542 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 33 BTK(1), LYN(1), NFATC2(1), NFATC4(1), PPP3CA(1), PPP3CC(1), PRKCA(1), RAC1(1), SHC1(1), SYK(2), SYT1(1) 18567183 12 9 12 6 5 3 1 3 0 0 0.890 1.000 1.000 543 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 20 AKT1(3), BCR(1), MAP2K4(2), STAT1(1), STAT5A(1), STAT5B(1) 12554511 9 9 8 4 1 4 1 3 0 0 0.805 1.000 1.000 544 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(1), GTF2A1(1), GTF2B(1), HDAC3(2), NCOA1(2), NCOA2(1), NCOA3(1) 12225140 9 9 9 4 4 3 0 2 0 0 0.754 1.000 1.000 545 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(1), CREBBP(2), PTPRC(3), ZAP70(2) 11306092 8 8 8 7 2 3 0 3 0 0 0.991 1.000 1.000 546 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 21 ADCY1(1), AKT1(3), BAD(1), IGF1R(2), IL3RA(1) 9727469 8 8 7 4 2 2 1 3 0 0 0.877 1.000 1.000 547 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CR1(1), FCGR2B(1), ITGAL(2), ITGB2(1), PTPRC(3) 7458063 8 8 8 5 3 3 0 2 0 0 0.933 1.000 1.000 548 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(1), CREBBP(2), PTPRC(3), ZAP70(2) 11306092 8 8 8 7 2 3 0 3 0 0 0.991 1.000 1.000 549 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(1), ACAT1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH1B1(1), ME3(1), PC(1) 18189660 9 8 9 4 1 2 3 3 0 0 0.861 1.000 1.000 550 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CREBBP(2), HDAC3(2), NFKB1(2), RELA(2) 10981192 8 8 8 5 3 2 0 3 0 0 0.930 1.000 1.000 551 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 NFATC2(1), NFKB1(2), PPP3CA(1), PPP3CC(1), RELA(2), SYT1(1) 13763110 8 8 8 4 4 1 1 2 0 0 0.853 1.000 1.000 552 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 20 CSNK2A1(1), PRKCA(1), SHC1(1), STAT1(1), STAT3(3), STAT5A(1), STAT5B(1) 13479997 9 7 9 4 3 2 0 4 0 0 0.820 1.000 1.000 553 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(1), PRKAA2(2), PRKAG1(2), PRKAG2(1) 7530757 6 6 6 3 2 0 1 3 0 0 0.908 1.000 1.000 554 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 20 BRCA1(2), CDC34(1), MYT1(1), PRKDC(3) 17104134 7 6 7 6 4 1 1 1 0 0 0.987 1.000 1.000 555 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 ITGA4(1), ITGAL(2), ITGB2(1), SELE(2) 5948612 6 6 6 3 2 2 1 1 0 0 0.883 1.000 1.000 556 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CAPNS1(1), NFATC2(1), PPP3CA(1), PPP3CC(1), PRKCA(1), SYT1(1) 11999370 6 6 6 4 2 0 1 3 0 0 0.935 1.000 1.000 557 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT10(1), GALNT3(1), GALNT4(1), GALNT8(1), ST3GAL1(1), WBSCR17(1) 7095988 6 6 6 3 0 5 0 1 0 0 0.809 1.000 1.000 558 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 27 MAP2K4(2), PRKCA(1), RAC1(1), SHC1(1), SYT1(1) 13764905 6 6 6 3 1 2 0 3 0 0 0.836 1.000 1.000 559 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(2), CETP(1), CYP7A1(1), LDLR(1), LRP1(1), SCARB1(1) 13487550 7 6 7 4 0 4 0 3 0 0 0.913 1.000 1.000 560 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 ITGAL(2), ITGB2(1), PTPRC(3) 5552516 6 6 6 6 1 3 0 2 0 0 0.986 1.000 1.000 561 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 21 CCNH(1), RB1(2), RBL1(1), TFDP1(1) 7735311 5 5 5 4 2 0 0 3 0 0 0.957 1.000 1.000 562 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(2), NCOA1(2), NCOA2(1), PPARG(1) 9116349 6 5 6 4 3 1 0 2 0 0 0.928 1.000 1.000 563 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 PTPRC(3), ZAP70(2) 4460931 5 5 5 4 0 3 0 2 0 0 0.957 1.000 1.000 564 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(1), ARHGAP5(2), CASP1(1) 6372276 4 4 4 3 0 3 1 0 0 0 0.952 1.000 1.000 565 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 18 CSNK2A1(1), SHC1(1), STAT5A(1), STAT5B(1) 10302618 4 4 4 4 2 2 0 0 0 0 0.963 1.000 1.000 566 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(1), ST3GAL1(1), ST6GALNAC2(1), ST6GALNAC4(1) 2770460 4 4 4 3 0 4 0 0 0 0 0.851 1.000 1.000 567 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 NOS3(2), VHL(2) 8344230 4 4 4 4 1 2 1 0 0 0 0.979 1.000 1.000 568 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(1), ACACB(1), FASN(1), OXSM(1) 7690864 4 4 4 4 1 0 1 2 0 0 0.987 1.000 1.000 569 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 LARS(1), LARS2(1), VARS(1), VARS2(1) 9135144 4 4 4 3 1 1 0 2 0 0 0.935 1.000 1.000 570 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT2(1), B4GALT2(1), B4GALT4(1), FUT8(1), ST3GAL1(1) 6130188 5 4 5 6 3 1 0 1 0 0 0.976 1.000 1.000 571 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 14 IL3RA(1), SHC1(1), STAT5A(1), STAT5B(1) 8497681 4 4 4 4 1 2 0 1 0 0 0.965 1.000 1.000 572 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(2), SPN(1), TNFRSF8(1) 6407805 4 4 4 3 3 1 0 0 0 0 0.887 1.000 1.000 573 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CREBBP(2), NCOA3(1) 10193447 3 3 3 4 1 0 0 2 0 0 0.990 1.000 1.000 574 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 LCT(1), PYGL(1), TPI1(1) 6578672 3 3 3 3 2 1 0 0 0 0 0.927 1.000 1.000 575 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B4GALT2(1), FUT8(1), ST3GAL1(1) 3862639 3 3 3 5 1 1 0 1 0 0 0.992 1.000 1.000 576 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 21 ACTA1(1), ADCY1(1), MYT1(1) 9862094 3 3 3 5 2 0 1 0 0 0 0.998 1.000 1.000 577 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(1), ADRB2(1), PLCE1(1) 7254107 3 3 3 4 2 0 1 0 0 0 0.995 1.000 1.000 578 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 CREBBP(2), NME1(1) 5223874 3 3 3 2 1 1 0 1 0 0 0.905 1.000 1.000 579 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(1), ADRB2(1) 6407639 2 2 2 4 1 0 1 0 0 0 0.999 1.000 1.000 580 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(1), PRKACA(1) 3229945 2 2 2 3 1 0 0 1 0 0 0.996 1.000 1.000 581 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(1), ALDH1B1(1) 4188083 2 2 2 2 1 0 0 1 0 0 0.955 1.000 1.000 582 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 APOBEC3B(1), APOBEC4(1) 3622104 2 2 2 2 1 1 0 0 0 0 0.964 1.000 1.000 583 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 ACAT1(1), LDLR(1) 2626695 2 2 2 3 0 1 1 0 0 0 0.987 1.000 1.000 584 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(2) 7231079 2 2 2 3 1 0 0 1 0 0 0.985 1.000 1.000 585 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(1), POLR2B(1) 6601566 2 2 2 2 0 0 1 1 0 0 0.971 1.000 1.000 586 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 PRKCA(1), PTPRA(1) 4530046 2 2 2 2 0 1 0 1 0 0 0.962 1.000 1.000 587 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 TGFBR1(1), TGFBR3(1) 5217566 2 2 2 3 0 1 0 1 0 0 0.987 1.000 1.000 588 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA10(1), NDUFS2(1) 3420566 2 2 2 2 0 1 0 1 0 0 0.958 1.000 1.000 589 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACAT1(1) 2668750 1 1 1 2 0 0 1 0 0 0 0.993 1.000 1.000 590 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 LSS(1) 5393125 1 1 1 2 1 0 0 0 0 0 0.987 1.000 1.000 591 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 B3GALT2(1) 3558492 1 1 1 2 0 1 0 0 0 0 0.984 1.000 1.000 592 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(1) 2092805 1 1 1 4 0 0 1 0 0 0 1.000 1.000 1.000 593 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 2723436 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 594 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 1955043 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 595 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 1166609 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 596 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 2505900 0 0 0 2 0 0 0 0 0 0 1.000 1.000 1.000 597 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 3016626 0 0 0 3 0 0 0 0 0 0 1.000 1.000 1.000 598 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 16 5237546 0 0 0 4 0 0 0 0 0 0 1.000 1.000 1.000 599 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 6323233 0 0 0 3 0 0 0 0 0 0 1.000 1.000 1.000 600 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 1495957 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 601 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 2421039 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 602 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 2349470 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 603 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 251649 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 604 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 1106799 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 605 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 1038804 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 606 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 1521609 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 607 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 2088048 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 608 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 3224718 0 0 0 2 0 0 0 0 0 0 1.000 1.000 1.000 609 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 4546828 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 610 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 1901020 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 611 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 845788 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 612 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 5 4409340 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 613 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 11 4726424 0 0 0 2 0 0 0 0 0 0 1.000 1.000 1.000 614 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 1586566 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 615 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 562845 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 616 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 1553474 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000