rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(12) 306695 12 12 11 3 10 1 1 0 0 0 0.131 0.239 1.000 2 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 CMBL(5) 219519 5 5 5 1 5 0 0 0 0 0 0.373 0.359 1.000 3 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(6), GOT2(6), TAT(21) 1124647 33 21 32 9 24 3 2 1 3 0 0.0125 0.898 1.000 4 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(5), CHRNA1(7), SNAP25(7), VAMP2(1) 1396359 20 18 18 3 14 1 0 2 3 0 0.00242 0.946 1.000 5 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(4), TPI1(1) 708066 5 5 4 1 3 0 0 2 0 0 0.339 0.972 1.000 6 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIAS(2), LIPT1(2) 659766 4 3 4 0 0 2 0 1 1 0 0.334 0.981 1.000 7 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3D(7), CD3E(2), CD3G(1) 480032 10 7 10 4 8 0 0 0 2 0 0.405 0.992 1.000 8 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(17), ADH1B(30), ADH4(12), ADH6(14), ADH7(16), ADHFE1(6) 2409018 95 71 78 29 77 4 5 6 3 0 0.00244 0.995 1.000 9 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(4), ALDOA(1), ALDOB(14), ALDOC(4), TPI1(1) 1685752 24 19 21 7 17 2 0 2 3 0 0.0344 0.997 1.000 10 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(7), ALDH1A2(16), RDH5(2) 1670003 25 20 22 6 15 2 0 4 4 0 0.0318 0.997 1.000 11 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 CDK5(6), FOSB(5), GRIA2(43), JUND(1), PPP1R1B(2) 1573577 57 49 54 22 34 3 2 9 9 0 0.132 0.999 1.000 12 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(9), SLPI(6) 734750 15 14 15 7 7 1 0 6 1 0 0.587 0.999 1.000 13 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 BGN(7), DCN(19), FMOD(6), KERA(16), LUM(12) 1512551 60 45 56 25 46 5 3 3 3 0 0.0224 1.000 1.000 14 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 GNAQ(6), NFKB1(6), NFKBIA(2), PLCB1(58), PRKCA(9), RELA(4) 3497971 85 60 76 28 64 3 3 8 7 0 0.0155 1.000 1.000 15 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALT(2), TGDS(1), UGDH(1), UXS1(5) 1645771 9 9 9 8 3 0 1 0 5 0 0.951 1.000 1.000 16 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 BCL2(3), CASP3(2), CASP8(9), CFL1(2), CFLAR(4), PDE6D(2) 1669286 22 20 21 9 10 2 2 5 3 0 0.487 1.000 1.000 17 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 7 SEC61A2(2), SRP19(2), SRP54(4), SRP68(8), SRP72(1), SRP9(1), SRPR(4) 2818836 22 21 22 6 8 0 1 6 7 0 0.355 1.000 1.000 18 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(34), GNAS(33), GNB1(1), PRKACA(3), PRKAR1A(3) 2790154 74 51 70 24 46 11 4 7 6 0 0.0123 1.000 1.000 19 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(5), ACADM(5), ACADS(5), ECHS1(3), HADHA(6) 2335984 24 23 24 8 14 4 1 4 1 0 0.288 1.000 1.000 20 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYA(1), NFYB(2), NFYC(2), RB1(10), SP1(5), SP3(1) 2847454 21 18 21 6 5 2 2 4 6 2 0.329 1.000 1.000 21 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALT(2), TGDS(1), UGDH(1), UGP2(1), UXS1(5) 2099109 10 10 10 9 4 0 1 0 5 0 0.960 1.000 1.000 22 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT2(1), HMGCL(4), OXCT1(4) 1438077 9 9 9 5 6 0 0 1 2 0 0.721 1.000 1.000 23 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD28(2), CD4(9), HLA-DRA(13), HLA-DRB1(5) 1006636 29 24 27 15 23 0 0 3 3 0 0.197 1.000 1.000 24 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(14), LPL(6), NR3C1(7), PPARG(12), RETN(3), RXRA(4), TNF(1) 2489206 47 40 44 17 29 7 0 6 5 0 0.0415 1.000 1.000 25 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ2(2), COQ3(2), COQ5(2), COQ6(2), COQ7(3), NDUFA12(1), NDUFA13(2) 1700209 14 14 14 7 9 1 2 0 2 0 0.606 1.000 1.000 26 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCL11(3), CCR3(11), CSF2(2), HLA-DRA(13), HLA-DRB1(5), IL3(3), IL5(4) 1295425 41 29 39 20 33 1 0 4 3 0 0.0602 1.000 1.000 27 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 6 HDAC1(2), MYC(5), SP1(5), SP3(1), WT1(10) 2678875 23 20 22 6 12 4 3 1 3 0 0.117 1.000 1.000 28 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(5), PLCD1(3), PRKCA(9), TGM2(11) 2124288 28 23 27 13 21 2 0 0 5 0 0.0890 1.000 1.000 29 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 11 CCNA1(16), CCND1(2), CCNE1(4), CCNE2(6), CDK2(1), CDKN1B(1), E2F1(6), E2F2(5), E2F4(3), PRB1(14) 3315113 58 43 56 18 43 0 3 7 5 0 0.0437 1.000 1.000 30 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(2), GLS2(3), GLUD1(2), GLUD2(4) 1942316 11 9 11 9 3 3 1 1 3 0 0.916 1.000 1.000 31 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP1(4), ACP2(3), ACP5(3), ACPP(9), ACPT(3), ENPP1(13), ENPP3(14), FLAD1(11), TYR(11) 4128130 71 50 68 20 46 4 2 5 14 0 0.0107 1.000 1.000 32 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDFT1(1), FDPS(3), IDI1(1), SQLE(4) 1354168 9 9 9 5 4 1 1 3 0 0 0.710 1.000 1.000 33 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 HRAS(3), MMP14(3), MMP2(9), MMP9(8), RECK(11), TIMP1(1), TIMP2(2), TIMP3(5), TIMP4(7) 3182420 49 38 47 19 25 4 3 9 8 0 0.129 1.000 1.000 34 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 B3GNT1(3), FUT1(4), FUT2(4), FUT9(29), GCNT2(1), ST8SIA1(1) 2568161 42 39 39 20 28 3 4 7 0 0 0.231 1.000 1.000 35 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 AKR1A1(4), ECHS1(3), EHHADH(6), HADHA(6), SDS(3) 2066224 22 19 20 10 14 3 0 3 2 0 0.356 1.000 1.000 36 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(5), AASDHPPT(3), AASS(3), KARS(4) 1992973 15 15 15 7 13 0 0 1 1 0 0.629 1.000 1.000 37 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 CAMP(2), DAG1(9), GNAQ(6), ITPKB(11) 2566827 28 24 26 12 20 0 2 2 4 0 0.164 1.000 1.000 38 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 12 CCND1(2), CDK2(1), CDKN1A(3), CDKN1B(1), CFL1(2), E2F1(6), E2F2(5), MDM2(4), NXT1(2), PRB1(14) 2727321 40 34 39 15 26 3 1 4 6 0 0.120 1.000 1.000 39 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(8), CDC25B(4), CDK7(2), CDKN1A(3), CHEK1(2), NEK1(7), WEE1(2) 2947162 28 23 28 8 15 5 1 4 3 0 0.226 1.000 1.000 40 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(16), GAD1(14), HDC(25), PNMT(4), TH(11), TPH1(12) 2549058 82 61 77 32 63 5 3 1 10 0 0.00163 1.000 1.000 41 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(2), CYCS(1), GPD2(3), SDHA(4), SDHC(3), SDHD(1), UQCRC1(4) 2839542 18 17 18 9 11 0 1 4 1 1 0.641 1.000 1.000 42 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 LDLR(17), NR0B2(6), NR1H3(4), NR1H4(14), RXRA(4) 2322057 45 32 45 19 28 7 3 5 2 0 0.0913 1.000 1.000 43 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(6), BAK1(2), BAX(4), BCL10(3), BCL2(3), BCL2L11(8), CASP9(2), CES1(21) 4579626 49 36 46 14 34 6 2 3 4 0 0.0550 1.000 1.000 44 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 AKR1A1(4), ECHS1(3), EHHADH(6), HADH(3), HADHA(6), HSD17B10(2), HSD17B4(6), NTAN1(2), SIRT1(2), SIRT2(1), SIRT5(6), SIRT7(3), VNN2(17) 5055319 61 50 59 18 38 8 4 7 4 0 0.0265 1.000 1.000 45 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CSF2(2), CSF3(4), EPO(5), FLT3(38), IGF1(11), IL11(3), IL1A(5), IL3(3), IL6(2), IL9(1), KITLG(10), TGFB1(2), TGFB2(3), TGFB3(3) 3515566 92 63 86 34 54 6 6 14 12 0 0.0122 1.000 1.000 46 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 PAPSS1(4), PAPSS2(5), SULT1A2(3), SULT1E1(16), SULT2A1(9), SUOX(4) 2605387 41 25 39 14 28 1 0 4 8 0 0.110 1.000 1.000 47 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(6), BMPR1A(2), BMPR1B(4), BMPR2(7) 2683733 19 19 19 9 10 3 1 3 2 0 0.554 1.000 1.000 48 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(9), CTH(1), GOT1(6), GOT2(6), LDHA(5), LDHB(2), LDHC(7), MPST(2) 2934593 38 30 36 15 27 2 6 2 1 0 0.150 1.000 1.000 49 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(13), IARS(10), LARS(13), LARS2(5), PDHA1(4), PDHA2(20), PDHB(1) 4290028 66 51 62 20 44 6 2 7 7 0 0.0641 1.000 1.000 50 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(5), AASDH(5), AASDHPPT(3), AASS(3), KARS(4) 2952936 20 18 20 9 17 0 0 1 2 0 0.608 1.000 1.000 51 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(6), FARSA(8), FARSB(5), GOT1(6), GOT2(6), PAH(12), TAT(21), YARS(3), YARS2(2) 3720330 69 50 66 29 44 7 2 5 11 0 0.0529 1.000 1.000 52 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 186 ACTB(9), ACTG1(7), ACTN1(8), ACTN2(21), ACTN4(5), AKT1(4), AKT2(8), AKT3(3), ARHGAP5(13), BCAR1(5), BCL2(3), BIRC2(6), BIRC3(7), CAPN2(6), CAV1(1), CAV3(2), CCND1(2), CCND2(7), CCND3(2), CDC42(2), CHAD(4), COL11A1(77), COL11A2(51), COL1A1(48), COL1A2(49), COL2A1(44), COL3A1(87), COL4A1(66), COL4A2(36), COL4A4(122), COL4A6(43), COL5A1(83), COL5A2(57), COL5A3(77), COL6A1(13), COL6A2(24), COL6A3(69), COL6A6(64), COMP(8), CRK(3), CRKL(2), DIAPH1(10), DOCK1(17), EGF(22), EGFR(25), ELK1(3), ERBB2(10), FARP2(7), FIGF(5), FLNA(23), FLNB(44), FLNC(69), FLT1(42), FN1(28), FYN(8), GRB2(2), GSK3B(3), HGF(30), HRAS(3), IBSP(9), IGF1(11), IGF1R(15), ILK(2), ITGA1(23), ITGA10(12), ITGA11(19), ITGA2(13), ITGA2B(12), ITGA3(8), ITGA4(45), ITGA5(25), ITGA6(12), ITGA7(25), ITGA8(39), ITGA9(15), ITGAV(11), ITGB1(4), ITGB3(16), ITGB4(22), ITGB5(9), ITGB6(11), ITGB7(7), ITGB8(19), JUN(1), KDR(57), LAMA1(46), LAMA2(69), LAMA3(70), LAMA4(12), LAMA5(41), LAMB1(13), LAMB2(14), LAMB3(26), LAMB4(47), LAMC1(13), LAMC2(21), LAMC3(11), MAPK1(4), MAPK10(9), MAPK3(3), MAPK8(2), MAPK9(4), MET(23), MYL2(9), MYL5(1), MYL7(3), MYL9(2), MYLK(48), MYLK2(13), PAK1(4), PAK2(9), PAK3(10), PAK4(8), PAK6(6), PAK7(55), PARVA(2), PARVB(4), PARVG(3), PDGFA(1), PDGFB(6), PDGFC(17), PDGFD(7), PDGFRA(32), PDGFRB(23), PDPK1(5), PGF(1), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(3), PIK3R2(6), PIK3R3(2), PIK3R5(17), PIP5K1C(9), PPP1CA(3), PPP1CB(5), PPP1CC(2), PPP1R12A(4), PRKCA(9), PRKCG(16), PTK2(7), PXN(2), RAC2(1), RAF1(11), RAP1A(1), RAP1B(1), RAPGEF1(14), RELN(90), RHOA(2), ROCK1(6), ROCK2(14), SHC1(2), SHC2(7), SHC3(15), SHC4(4), SOS1(10), SOS2(13), SPP1(7), SRC(2), THBS1(31), THBS2(14), THBS3(12), THBS4(19), TLN1(12), TLN2(27), TNC(35), TNN(55), TNR(84), TNXB(126), VASP(3), VAV1(19), VAV2(5), VAV3(11), VCL(9), VEGFA(4), VEGFB(2), VTN(9), VWF(59), ZYX(8) 155437037 3523 265 3355 1596 2475 248 99 295 382 24 5.55e-07 1.000 1.000 53 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 ACTB(9), ACTG1(7), CHAD(4), COL11A1(77), COL11A2(51), COL17A1(29), COL1A1(48), COL1A2(49), COL2A1(44), COL3A1(87), COL4A1(66), COL4A2(36), COL4A4(122), COL4A6(43), COL5A1(83), COL5A2(57), COL5A3(77), COL6A1(13), COL6A2(24), COL6A3(69), COL6A6(64), COMP(8), DES(9), DSC1(57), DSC2(45), DSC3(50), DSG1(64), DSG2(26), DSG3(68), DSG4(70), FN1(28), GJA1(10), GJA10(18), GJA3(1), GJA4(4), GJA5(11), GJA8(20), GJA9(3), GJB1(1), GJB2(3), GJB3(4), GJB4(8), GJB5(8), GJB6(6), GJB7(2), GJC1(7), GJC3(2), GJD2(5), IBSP(9), INA(7), ITGA6(12), ITGB4(22), KRT1(22), KRT10(14), KRT12(11), KRT13(13), KRT14(3), KRT15(10), KRT16(10), KRT17(9), KRT18(4), KRT19(3), KRT2(18), KRT20(7), KRT23(10), KRT24(7), KRT25(14), KRT27(6), KRT28(13), KRT3(16), KRT31(9), KRT32(15), KRT33A(6), KRT33B(4), KRT34(12), KRT35(11), KRT36(18), KRT37(13), KRT38(10), KRT39(16), KRT4(22), KRT40(7), KRT5(16), KRT6A(15), KRT6B(9), KRT6C(14), KRT7(5), KRT71(18), KRT72(11), KRT73(18), KRT74(16), KRT75(16), KRT76(17), KRT77(15), KRT78(24), KRT79(8), KRT8(7), KRT81(4), KRT82(7), KRT83(16), KRT84(12), KRT85(7), KRT86(8), KRT9(23), LAMA1(46), LAMA2(69), LAMA3(70), LAMA4(12), LAMA5(41), LAMB1(13), LAMB2(14), LAMB3(26), LAMB4(47), LAMC1(13), LAMC2(21), LAMC3(11), LMNA(5), LMNB1(2), LMNB2(4), NES(25), PRPH(1), RELN(90), SPP1(7), THBS1(31), THBS2(14), THBS3(12), THBS4(19), TNC(35), TNN(55), TNR(84), TNXB(126), VIM(6), VTN(9), VWF(59) 106337368 3233 260 3055 1413 2362 234 79 225 315 18 1.16e-10 1.000 1.000 54 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 234 ADCYAP1R1(19), ADORA1(5), ADORA2A(3), ADORA2B(1), ADORA3(12), ADRA1A(13), ADRA1B(5), ADRA2A(3), ADRA2B(10), ADRA2C(2), ADRB1(5), ADRB2(4), AGTR1(10), AGTR2(10), AVPR1A(4), AVPR1B(13), BDKRB1(6), BDKRB2(10), BRS3(5), C3AR1(6), C5AR1(10), CALCR(19), CALCRL(19), CCKAR(12), CCKBR(11), CGA(1), CHRM1(5), CHRM2(26), CHRM3(26), CHRM4(6), CHRM5(7), CNR1(12), CNR2(6), CRHR1(7), CRHR2(5), CTSG(5), CYSLTR1(5), CYSLTR2(4), DRD1(9), DRD2(16), DRD3(5), DRD4(1), DRD5(25), EDNRA(11), EDNRB(7), F2(13), F2R(8), F2RL1(9), F2RL2(8), F2RL3(5), FPR1(22), FSHB(9), FSHR(21), GABBR1(9), GABBR2(12), GABRA1(20), GABRA2(19), GABRA3(24), GABRA4(15), GABRA5(4), GABRA6(29), GABRB1(16), GABRB2(26), GABRB3(23), GABRD(5), GABRE(24), GABRG2(20), GABRG3(10), GABRP(16), GABRQ(12), GABRR1(10), GALR1(5), GALR3(2), GH1(5), GH2(7), GHR(43), GHRHR(6), GHSR(11), GIPR(4), GLP1R(13), GLP2R(15), GLRA1(13), GLRA2(6), GLRA3(16), GNRHR(2), GPR156(15), GPR35(6), GPR50(19), GPR63(9), GPR83(14), GRIA1(47), GRIA2(43), GRIA3(26), GRIA4(26), GRID1(27), GRID2(60), GRIK1(30), GRIK2(31), GRIK3(34), GRIK4(16), GRIK5(12), GRIN1(8), GRIN2A(107), GRIN2B(59), GRIN2C(10), GRIN2D(11), GRIN3A(50), GRIN3B(5), GRM1(13), GRM2(16), GRM3(62), GRM4(22), GRM5(17), GRM6(32), GRM7(41), GRM8(47), GRPR(7), GZMA(13), HCRTR1(2), HCRTR2(34), HRH1(15), HRH2(3), HRH3(5), HRH4(6), HTR1A(11), HTR1B(2), HTR1D(7), HTR1E(7), HTR1F(9), HTR2A(11), HTR2B(2), HTR2C(14), HTR4(8), HTR5A(19), HTR6(3), HTR7(10), LEP(4), LEPR(31), LHB(1), LHCGR(29), LTB4R(1), LTB4R2(1), MAS1(4), MC1R(1), MC2R(5), MC3R(7), MC4R(1), MC5R(8), MCHR1(4), MCHR2(21), MLNR(2), MTNR1A(10), MTNR1B(8), NMBR(8), NMUR1(7), NMUR2(16), NPBWR1(3), NPBWR2(12), NPFFR1(1), NPFFR2(14), NPY1R(29), NPY2R(13), NPY5R(25), NR3C1(7), NTSR1(8), NTSR2(2), OPRD1(3), OPRK1(23), OPRL1(8), OPRM1(5), OXTR(6), P2RX1(3), P2RX2(3), P2RX3(8), P2RX4(2), P2RX5(6), P2RX7(4), P2RY1(5), P2RY10(7), P2RY11(2), P2RY13(4), P2RY14(8), P2RY2(10), P2RY4(2), P2RY6(2), P2RY8(9), PARD3(20), PRL(3), PRLHR(1), PRLR(37), PRSS1(26), PRSS3(6), PTAFR(2), PTGDR(12), PTGER2(7), PTGER3(4), PTGER4(3), PTGFR(21), PTGIR(5), PTH2R(18), RXFP1(19), RXFP2(25), SCTR(8), SSTR1(10), SSTR2(7), SSTR3(13), SSTR4(4), SSTR5(4), TAAR1(3), TAAR2(11), TAAR5(4), TAAR6(11), TAAR8(7), TACR1(8), TACR2(9), TACR3(29), TBXA2R(4), THRA(2), THRB(18), TRHR(24), TRPV1(3), TSHB(7), TSHR(8), UTS2R(1), VIPR1(7), VIPR2(7) 92988565 2867 258 2645 1801 1967 251 97 264 275 13 4.25e-09 1.000 1.000 55 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(16), CD36(6), CD44(5), CD47(1), CHAD(4), COL11A1(77), COL11A2(51), COL1A1(48), COL1A2(49), COL2A1(44), COL3A1(87), COL4A1(66), COL4A2(36), COL4A4(122), COL4A6(43), COL5A1(83), COL5A2(57), COL5A3(77), COL6A1(13), COL6A2(24), COL6A3(69), COL6A6(64), DAG1(9), FN1(28), FNDC1(44), FNDC3A(12), FNDC4(5), FNDC5(3), GP5(6), GP6(5), GP9(6), HMMR(5), HSPG2(31), IBSP(9), ITGA1(23), ITGA10(12), ITGA11(19), ITGA2(13), ITGA2B(12), ITGA3(8), ITGA4(45), ITGA5(25), ITGA6(12), ITGA7(25), ITGA8(39), ITGA9(15), ITGAV(11), ITGB1(4), ITGB3(16), ITGB4(22), ITGB5(9), ITGB6(11), ITGB7(7), ITGB8(19), LAMA1(46), LAMA2(69), LAMA3(70), LAMA4(12), LAMA5(41), LAMB1(13), LAMB2(14), LAMB3(26), LAMB4(47), LAMC1(13), LAMC2(21), LAMC3(11), RELN(90), SDC1(3), SDC2(2), SDC3(7), SDC4(3), SPP1(7), SV2A(17), SV2B(27), SV2C(22), THBS1(31), THBS2(14), THBS3(12), THBS4(19), TNC(35), TNN(55), TNR(84), TNXB(126), VTN(9), VWF(59) 95453432 2557 257 2437 1106 1845 160 78 178 277 19 0.000252 1.000 1.000 56 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 242 ACVR1B(3), ACVR1C(10), AKT1(4), AKT2(8), AKT3(3), ARRB1(4), ARRB2(7), ATF2(6), ATF4(9), BDNF(5), CACNA1A(38), CACNA1B(38), CACNA1C(60), CACNA1D(36), CACNA1E(113), CACNA1F(24), CACNA1G(37), CACNA1H(29), CACNA1I(41), CACNA1S(54), CACNA2D1(16), CACNA2D2(16), CACNA2D3(61), CACNA2D4(26), CACNB1(4), CACNB2(14), CACNB3(3), CACNB4(13), CACNG1(4), CACNG2(11), CACNG3(25), CACNG4(4), CACNG5(11), CACNG6(6), CACNG7(7), CACNG8(1), CASP3(2), CD14(6), CDC25B(4), CDC42(2), CHUK(2), CRK(3), CRKL(2), DAXX(10), DDIT3(3), DUSP1(1), DUSP10(9), DUSP14(2), DUSP16(4), DUSP2(1), DUSP3(1), DUSP4(3), DUSP5(2), DUSP6(2), DUSP7(2), DUSP8(3), DUSP9(3), ECSIT(2), EGF(22), EGFR(25), ELK1(3), ELK4(6), FAS(5), FASLG(15), FGF1(1), FGF10(3), FGF11(3), FGF12(15), FGF13(7), FGF14(5), FGF16(4), FGF17(2), FGF18(3), FGF19(3), FGF2(1), FGF20(2), FGF21(6), FGF23(10), FGF3(5), FGF4(2), FGF5(11), FGF6(6), FGF7(7), FGF8(1), FGF9(4), FGFR1(12), FGFR2(33), FGFR3(9), FGFR4(12), FLNA(23), FLNB(44), FLNC(69), FOS(2), GADD45B(2), GNA12(3), GRB2(2), HRAS(3), IKBKB(4), IL1A(5), IL1B(8), IL1R1(12), IL1R2(7), JUN(1), JUND(1), KRAS(7), MAP2K2(5), MAP2K3(9), MAP2K4(4), MAP2K5(5), MAP2K6(3), MAP2K7(5), MAP3K1(4), MAP3K10(13), MAP3K12(3), MAP3K13(15), MAP3K2(8), MAP3K3(8), MAP3K4(19), MAP3K5(23), MAP3K6(5), MAP3K7(1), MAP4K1(12), MAP4K2(7), MAP4K3(10), MAP4K4(12), MAPK1(4), MAPK10(9), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MAPK3(3), MAPK7(4), MAPK8(2), MAPK8IP1(7), MAPK8IP2(8), MAPK8IP3(9), MAPK9(4), MAPKAPK2(5), MAPKAPK3(5), MAPKAPK5(1), MAPT(10), MEF2C(3), MKNK1(6), MKNK2(4), MOS(6), MRAS(2), MYC(5), NF1(46), NFATC2(12), NFATC4(18), NFKB1(6), NFKB2(5), NLK(5), NR4A1(4), NTF3(7), NTRK1(16), NTRK2(11), PAK1(4), PAK2(9), PDGFA(1), PDGFB(6), PDGFRA(32), PDGFRB(23), PLA2G12B(3), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(19), PLA2G4A(16), PLA2G5(2), PLA2G6(13), PPM1A(3), PPM1B(2), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP5C(4), PRKACA(3), PRKACB(4), PRKACG(10), PRKCA(9), PRKCG(16), PRKX(3), PTPN5(13), PTPN7(2), PTPRR(30), RAC2(1), RAF1(11), RAP1A(1), RAP1B(1), RAPGEF2(9), RASA1(5), RASA2(15), RASGRF1(22), RASGRF2(24), RASGRP1(11), RASGRP2(8), RASGRP3(12), RASGRP4(12), RPS6KA1(9), RPS6KA2(6), RPS6KA3(2), RPS6KA4(4), RPS6KA5(7), RPS6KA6(21), RRAS(1), RRAS2(1), SOS1(10), SOS2(13), SRF(3), STK3(1), STK4(4), STMN1(3), TAOK1(11), TAOK2(24), TAOK3(4), TGFB1(2), TGFB2(3), TGFB3(3), TGFBR2(9), TNF(1), TNFRSF1A(4), TRAF2(2), TRAF6(4), ZAK(7) 118737394 2214 255 2126 1322 1433 210 70 211 273 17 0.490 1.000 1.000 57 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 168 ADCY1(34), ADCY2(10), ADCY3(3), ADCY4(5), ADCY7(13), ADCY8(54), ADCY9(11), ADORA2A(3), ADORA2B(1), ADRA1A(13), ADRA1B(5), ADRA1D(4), ADRB1(5), ADRB2(4), AGTR1(10), ATP2A1(13), ATP2A2(14), ATP2A3(15), ATP2B1(7), ATP2B2(30), ATP2B3(9), ATP2B4(17), AVPR1A(4), AVPR1B(13), BDKRB1(6), BDKRB2(10), BST1(2), CACNA1A(38), CACNA1B(38), CACNA1C(60), CACNA1D(36), CACNA1E(113), CACNA1F(24), CACNA1G(37), CACNA1H(29), CACNA1I(41), CACNA1S(54), CALM1(1), CALM2(1), CALML3(9), CALML6(1), CAMK2A(6), CAMK2B(6), CAMK2D(6), CAMK2G(5), CAMK4(17), CCKAR(12), CCKBR(11), CD38(6), CHRM1(5), CHRM2(26), CHRM3(26), CHRM5(7), CHRNA7(3), CYSLTR1(5), CYSLTR2(4), DRD1(9), EDNRA(11), EDNRB(7), EGFR(25), ERBB2(10), ERBB3(5), ERBB4(59), F2R(8), GNA11(9), GNA14(7), GNA15(7), GNAL(2), GNAQ(6), GNAS(33), GRIN1(8), GRIN2A(107), GRIN2C(10), GRIN2D(11), GRM1(13), GRM5(17), GRPR(7), HRH1(15), HRH2(3), HTR2A(11), HTR2B(2), HTR2C(14), HTR4(8), HTR5A(19), HTR6(3), HTR7(10), ITPKB(11), ITPR1(36), ITPR2(20), ITPR3(12), LHCGR(29), LTB4R2(1), MYLK(48), MYLK2(13), NOS1(77), NOS3(20), NTSR1(8), OXTR(6), P2RX1(3), P2RX2(3), P2RX3(8), P2RX4(2), P2RX5(6), P2RX7(4), PDE1A(44), PDE1B(15), PDE1C(54), PDGFRA(32), PDGFRB(23), PHKA1(25), PHKA2(9), PHKB(10), PHKG1(3), PHKG2(3), PLCB1(58), PLCB2(12), PLCB3(4), PLCB4(87), PLCD1(3), PLCD3(4), PLCD4(5), PLCE1(56), PLCG1(9), PLCG2(30), PLCZ1(30), PPID(1), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKACA(3), PRKACB(4), PRKACG(10), PRKCA(9), PRKCG(16), PRKX(3), PTAFR(2), PTGER3(4), PTGFR(21), PTK2B(12), RYR1(114), RYR2(99), RYR3(96), SLC25A6(2), SLC8A1(35), SLC8A2(14), SLC8A3(45), SPHK1(2), SPHK2(8), TACR1(8), TACR2(9), TACR3(29), TBXA2R(4), TNNC1(2), TNNC2(5), TRHR(24), TRPC1(6), VDAC1(1), VDAC2(1), VDAC3(1) 113494033 2822 255 2650 1779 1960 209 101 226 305 21 0.000147 1.000 1.000 58 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 249 ACVR1(2), ACVR1B(3), ACVR2A(5), ACVR2B(3), AMHR2(15), BMP2(7), BMP7(5), BMPR1A(2), BMPR1B(4), BMPR2(7), CCL1(3), CCL11(3), CCL14(2), CCL15(3), CCL16(2), CCL18(1), CCL2(3), CCL20(2), CCL21(2), CCL22(2), CCL23(1), CCL24(3), CCL25(1), CCL26(3), CCL27(2), CCL28(1), CCL7(5), CCL8(3), CCR1(10), CCR2(17), CCR3(11), CCR4(9), CCR5(10), CCR6(4), CCR7(4), CCR8(8), CCR9(6), CD27(3), CD40(4), CD40LG(1), CLCF1(1), CNTF(2), CNTFR(4), CRLF2(8), CSF1(12), CSF1R(13), CSF2(2), CSF2RA(23), CSF2RB(24), CSF3(4), CSF3R(10), CX3CL1(5), CX3CR1(16), CXCL10(3), CXCL11(1), CXCL12(2), CXCL13(2), CXCL14(3), CXCL3(2), CXCL5(3), CXCL6(2), CXCL9(2), CXCR3(4), CXCR4(3), CXCR6(6), EDA(2), EDA2R(4), EDAR(8), EGF(22), EGFR(25), EPO(5), EPOR(1), FAS(5), FASLG(15), FLT1(42), FLT3(38), FLT3LG(1), FLT4(31), GDF5(16), GH1(5), GH2(7), GHR(43), HGF(30), IFNA1(1), IFNA10(2), IFNA13(1), IFNA14(8), IFNA16(11), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA5(4), IFNA6(3), IFNA7(6), IFNA8(3), IFNAR1(3), IFNAR2(8), IFNB1(6), IFNG(4), IFNGR1(3), IFNGR2(4), IFNK(2), IFNW1(4), IL10(2), IL10RA(9), IL10RB(7), IL11(3), IL11RA(3), IL12A(4), IL12B(3), IL12RB1(15), IL12RB2(3), IL13(2), IL13RA1(4), IL15(3), IL15RA(6), IL17A(8), IL17B(4), IL17RA(5), IL17RB(2), IL18(3), IL18R1(21), IL18RAP(26), IL19(2), IL1A(5), IL1B(8), IL1R1(12), IL1R2(7), IL1RAP(3), IL2(4), IL20(4), IL20RA(11), IL21(6), IL21R(19), IL22(2), IL22RA1(13), IL22RA2(3), IL23A(2), IL23R(8), IL25(1), IL26(4), IL2RA(7), IL2RB(12), IL2RG(3), IL3(3), IL3RA(8), IL4(1), IL4R(18), IL5(4), IL5RA(16), IL6(2), IL6R(3), IL6ST(11), IL7(5), IL7R(37), IL9(1), IL9R(6), INHBA(20), INHBB(9), INHBC(13), INHBE(5), KDR(57), KIT(13), KITLG(10), LEP(4), LEPR(31), LIF(1), LIFR(39), LTA(5), LTB(3), MET(23), MPL(9), NGFR(8), OSM(5), OSMR(40), PDGFB(6), PDGFC(17), PDGFRA(32), PDGFRB(23), PF4V1(1), PLEKHO2(5), PPBP(6), PRL(3), PRLR(37), RELT(2), TGFB1(2), TGFB2(3), TGFB3(3), TGFBR2(9), TNF(1), TNFRSF10A(7), TNFRSF10B(5), TNFRSF10C(4), TNFRSF10D(9), TNFRSF11A(5), TNFRSF11B(15), TNFRSF12A(1), TNFRSF13B(11), TNFRSF14(3), TNFRSF17(7), TNFRSF18(5), TNFRSF19(2), TNFRSF1A(4), TNFRSF1B(4), TNFRSF21(14), TNFRSF25(6), TNFRSF4(5), TNFRSF6B(4), TNFRSF8(19), TNFRSF9(4), TNFSF10(9), TNFSF11(5), TNFSF12(2), TNFSF13B(3), TNFSF14(9), TNFSF15(8), TNFSF18(9), TNFSF4(5), TNFSF8(3), TNFSF9(4), TPO(47), TSLP(2), VEGFA(4), VEGFB(2), XCL1(1), XCL2(2), XCR1(7) 74935173 1808 253 1720 969 1254 137 48 158 210 1 0.00338 1.000 1.000 59 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 199 ABI2(2), ACTN1(8), ACTN2(21), ACTN4(5), APC(27), APC2(12), ARAF(5), ARHGEF1(1), ARHGEF12(13), ARHGEF4(6), ARHGEF6(11), ARHGEF7(5), ARPC1B(3), ARPC2(1), ARPC3(2), ARPC4(1), ARPC5(1), BAIAP2(8), BCAR1(5), BDKRB1(6), BDKRB2(10), CD14(6), CDC42(2), CFL1(2), CHRM1(5), CHRM2(26), CHRM3(26), CHRM4(6), CHRM5(7), CRK(3), CRKL(2), CSK(1), CYFIP1(8), CYFIP2(26), DIAPH1(10), DIAPH2(8), DIAPH3(20), DOCK1(17), EGF(22), EGFR(25), EZR(7), F2(13), F2R(8), FGD1(5), FGD3(9), FGF1(1), FGF10(3), FGF11(3), FGF12(15), FGF13(7), FGF14(5), FGF16(4), FGF17(2), FGF18(3), FGF19(3), FGF2(1), FGF20(2), FGF21(6), FGF23(10), FGF3(5), FGF4(2), FGF5(11), FGF6(6), FGF7(7), FGF8(1), FGF9(4), FGFR1(12), FGFR2(33), FGFR3(9), FGFR4(12), FN1(28), GIT1(6), GNA12(3), GNA13(1), GSN(6), HRAS(3), IQGAP1(10), IQGAP2(29), IQGAP3(13), ITGA1(23), ITGA10(12), ITGA11(19), ITGA2(13), ITGA2B(12), ITGA3(8), ITGA4(45), ITGA5(25), ITGA6(12), ITGA7(25), ITGA8(39), ITGA9(15), ITGAD(31), ITGAE(21), ITGAL(27), ITGAM(25), ITGAV(11), ITGAX(25), ITGB1(4), ITGB2(17), ITGB3(16), ITGB4(22), ITGB5(9), ITGB6(11), ITGB7(7), ITGB8(19), KRAS(7), LIMK1(5), LIMK2(12), MAP2K2(5), MAPK1(4), MAPK3(3), MOS(6), MRAS(2), MSN(2), MYH10(14), MYH14(24), MYH9(12), MYL2(9), MYL5(1), MYL7(3), MYL9(2), MYLK(48), MYLK2(13), NCKAP1(5), NCKAP1L(44), PAK1(4), PAK2(9), PAK3(10), PAK4(8), PAK6(6), PAK7(55), PDGFA(1), PDGFB(6), PDGFRA(32), PDGFRB(23), PFN4(1), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(3), PIK3R2(6), PIK3R3(2), PIK3R5(17), PIP4K2A(6), PIP4K2B(3), PIP4K2C(2), PIP5K1A(6), PIP5K1B(21), PIP5K1C(9), PPP1CA(3), PPP1CB(5), PPP1CC(2), PPP1R12A(4), PPP1R12B(9), PTK2(7), PXN(2), RAC2(1), RAF1(11), RDX(4), RHOA(2), ROCK1(6), ROCK2(14), RRAS(1), RRAS2(1), SCIN(9), SLC9A1(5), SOS1(10), SOS2(13), SSH1(15), SSH2(7), SSH3(4), TIAM1(28), TIAM2(28), VAV1(19), VAV2(5), VAV3(11), VCL(9), WAS(8), WASF1(5), WASF2(6), WASL(4) 115761986 1941 253 1865 1050 1253 150 72 234 220 12 0.0308 1.000 1.000 60 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 124 ABL1(15), ABLIM1(15), ABLIM2(10), ABLIM3(8), ARHGEF12(13), CDC42(2), CDK5(6), CFL1(2), CXCL12(2), CXCR4(3), DCC(102), DPYSL2(4), DPYSL5(15), EFNA1(1), EFNA2(1), EFNA4(2), EFNA5(4), EFNB1(2), EFNB3(3), EPHA1(22), EPHA2(18), EPHA3(34), EPHA4(22), EPHA5(7), EPHA6(78), EPHA7(54), EPHA8(21), EPHB1(31), EPHB2(36), EPHB3(17), EPHB4(15), EPHB6(26), FES(7), FYN(8), GNAI1(2), GNAI3(2), GSK3B(3), HRAS(3), ITGB1(4), KRAS(7), L1CAM(11), LIMK1(5), LIMK2(12), LRRC4C(50), MAPK1(4), MAPK3(3), MET(23), NCK1(2), NCK2(4), NFAT5(11), NFATC1(17), NFATC2(12), NFATC3(11), NFATC4(18), NGEF(13), NRP1(24), NTN4(19), NTNG1(14), PAK1(4), PAK2(9), PAK3(10), PAK4(8), PAK6(6), PAK7(55), PLXNA1(12), PLXNA2(10), PLXNA3(17), PLXNB1(23), PLXNB2(17), PLXNB3(6), PLXNC1(18), PPP3CA(5), PPP3CB(4), PPP3CC(2), PTK2(7), RAC2(1), RASA1(5), RGS3(16), RHOA(2), RHOD(2), RND1(6), ROBO1(25), ROBO2(47), ROBO3(19), ROCK1(6), ROCK2(14), SEMA3A(15), SEMA3C(4), SEMA3D(15), SEMA3E(31), SEMA3F(12), SEMA3G(15), SEMA4A(9), SEMA4B(4), SEMA4C(13), SEMA4D(10), SEMA4F(8), SEMA4G(8), SEMA5A(17), SEMA5B(21), SEMA6A(10), SEMA6B(8), SEMA6C(9), SEMA6D(7), SEMA7A(4), SLIT1(17), SLIT2(66), SLIT3(63), SRGAP1(7), SRGAP2(8), SRGAP3(39), UNC5A(13), UNC5B(12), UNC5C(19), UNC5D(35) 82507814 1735 246 1621 903 1183 142 49 167 185 9 0.00232 1.000 1.000 61 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ADCY1(34), ADCY2(10), ADCY3(3), ADCY4(5), ADCY5(19), ADCY6(9), ADCY7(13), ADCY8(54), ADCY9(11), ADRA1A(13), ADRA1B(5), ADRA1D(4), ADRB1(5), ADRB2(4), ANXA6(6), ARRB1(4), ARRB2(7), ATP1A4(15), ATP1B1(2), ATP1B3(1), ATP2A2(14), ATP2A3(15), ATP2B1(7), ATP2B2(30), ATP2B3(9), CACNA1A(38), CACNA1B(38), CACNA1C(60), CACNA1D(36), CACNA1E(113), CACNA1S(54), CACNB1(4), CACNB3(3), CALM1(1), CALM2(1), CALR(2), CAMK1(5), CAMK2A(6), CAMK2B(6), CAMK2D(6), CAMK2G(5), CAMK4(17), CASQ1(8), CASQ2(5), CHRM1(5), CHRM2(26), CHRM3(26), CHRM4(6), CHRM5(7), GJA1(10), GJA4(4), GJA5(11), GJB1(1), GJB2(3), GJB3(4), GJB4(8), GJB5(8), GJB6(6), GNA11(9), GNAI3(2), GNAO1(1), GNAQ(6), GNAZ(7), GNB1(1), GNB2(1), GNB3(7), GNB4(4), GNB5(2), GNG2(3), GNG4(3), GNG7(2), GRK4(10), GRK5(5), GRK6(3), ITPR1(36), ITPR2(20), ITPR3(12), KCNB1(37), KCNJ3(21), KCNJ5(13), MIB1(6), NME7(5), PKIA(3), PKIB(1), PKIG(1), PLCB3(4), PRKACA(3), PRKACB(4), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCA(9), PRKCD(5), PRKCE(7), PRKCG(16), PRKCH(9), PRKCQ(21), PRKCZ(3), PRKD1(9), RGS1(5), RGS11(4), RGS14(3), RGS16(3), RGS18(8), RGS2(2), RGS20(2), RGS3(16), RGS4(4), RGS5(4), RGS6(20), RGS7(41), RGS9(16), RYR1(114), RYR2(99), RYR3(96), SFN(2), SLC8A1(35), SLC8A3(45), USP5(8), YWHAB(1), YWHAQ(3) 78911028 1687 240 1591 1159 1151 146 72 130 179 9 0.432 1.000 1.000 62 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 126 ACTB(9), ACTG1(7), ACTN1(8), ACTN2(21), ACTN4(5), AKT1(4), AKT2(8), AKT3(3), AMOTL1(4), ASH1L(37), CASK(6), CDC42(2), CGN(9), CLDN1(5), CLDN10(8), CLDN11(5), CLDN14(5), CLDN15(1), CLDN16(7), CLDN17(5), CLDN18(11), CLDN19(2), CLDN2(6), CLDN20(1), CLDN22(2), CLDN3(3), CLDN4(12), CLDN6(9), CLDN7(1), CLDN8(4), CLDN9(1), CSNK2A1(2), CSNK2A2(1), CSNK2B(1), CTNNA1(3), CTNNA2(28), CTNNA3(39), CTTN(4), EPB41(9), EPB41L1(16), EPB41L2(21), EPB41L3(7), EXOC3(6), EXOC4(12), F11R(7), GNAI1(2), GNAI3(2), HCLS1(15), HRAS(3), IGSF5(12), INADL(43), JAM2(11), JAM3(3), KRAS(7), LLGL1(5), LLGL2(16), MAGI1(38), MAGI2(24), MAGI3(12), MLLT4(17), MPDZ(13), MPP5(1), MRAS(2), MYH1(103), MYH10(14), MYH11(31), MYH13(55), MYH14(24), MYH15(64), MYH2(100), MYH3(31), MYH4(100), MYH6(40), MYH7(58), MYH7B(22), MYH8(66), MYH9(12), MYL2(9), MYL5(1), MYL7(3), MYL9(2), OCLN(6), PARD3(20), PARD6A(1), PARD6B(2), PARD6G(4), PPM1J(1), PPP2CA(1), PPP2CB(2), PPP2R1A(4), PPP2R1B(5), PPP2R2A(5), PPP2R2B(6), PPP2R2C(8), PPP2R3A(10), PPP2R3B(5), PPP2R4(2), PRKCA(9), PRKCD(5), PRKCE(7), PRKCG(16), PRKCH(9), PRKCI(8), PRKCQ(21), PRKCZ(3), RAB3B(1), RHOA(2), RRAS(1), RRAS2(1), SPTAN1(10), SRC(2), SYMPK(7), TJAP1(5), TJP1(16), TJP2(10), TJP3(20), VAPA(2), YES1(4), ZAK(7) 80546703 1576 238 1470 1018 1070 136 41 148 171 10 0.708 1.000 1.000 63 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 130 ALCAM(7), CADM1(5), CADM3(19), CD2(29), CD22(26), CD226(6), CD274(1), CD276(8), CD28(2), CD34(4), CD4(9), CD40(4), CD40LG(1), CD58(1), CD6(12), CD80(4), CD86(25), CD8A(2), CD8B(9), CD99(1), CDH1(6), CDH15(10), CDH2(16), CDH4(40), CDH5(12), CLDN1(5), CLDN10(8), CLDN11(5), CLDN14(5), CLDN15(1), CLDN16(7), CLDN17(5), CLDN18(11), CLDN19(2), CLDN2(6), CLDN20(1), CLDN22(2), CLDN3(3), CLDN4(12), CLDN6(9), CLDN7(1), CLDN8(4), CLDN9(1), CNTN1(28), CNTN2(16), CNTNAP1(12), CNTNAP2(94), CTLA4(2), ESAM(5), F11R(7), GLG1(6), HLA-A(4), HLA-B(6), HLA-C(2), HLA-DMA(7), HLA-DMB(7), HLA-DOA(6), HLA-DOB(9), HLA-DPA1(2), HLA-DPB1(2), HLA-DQA1(7), HLA-DQA2(8), HLA-DQB1(4), HLA-DRA(13), HLA-DRB1(5), HLA-DRB5(1), HLA-E(1), HLA-F(2), HLA-G(5), ICAM1(2), ICAM2(4), ICAM3(3), ICOS(3), ICOSLG(2), ITGA4(45), ITGA6(12), ITGA8(39), ITGA9(15), ITGAL(27), ITGAM(25), ITGAV(11), ITGB1(4), ITGB2(17), ITGB7(7), ITGB8(19), JAM2(11), JAM3(3), L1CAM(11), MADCAM1(1), MAG(12), MPZ(4), MPZL1(2), NCAM1(18), NCAM2(11), NEGR1(9), NEO1(16), NFASC(52), NLGN1(12), NLGN2(7), NLGN3(6), NRCAM(10), NRXN1(56), NRXN2(20), NRXN3(35), OCLN(6), PDCD1(4), PDCD1LG2(3), PTPRC(36), PTPRF(35), PTPRM(8), PVR(2), PVRL1(4), PVRL2(6), PVRL3(5), SDC1(3), SDC2(2), SDC3(7), SDC4(3), SELE(33), SELL(12), SELP(38), SELPLG(11), SIGLEC1(34), SPN(5), VCAM1(17), VCAN(44) 62403116 1457 236 1371 709 994 108 53 151 146 5 2.34e-05 1.000 1.000 64 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(4), ACTA2(5), ACTN2(21), ACTN4(5), DES(9), DMD(41), MYBPC1(27), MYBPC2(21), MYBPC3(16), MYH3(31), MYH6(40), MYH7(58), MYH8(66), MYL1(12), MYL2(9), MYL3(2), MYL4(6), MYL9(2), MYOM1(24), NEB(126), TNNC2(5), TNNI2(2), TNNI3(3), TNNT1(3), TNNT2(5), TNNT3(5), TPM1(4), TPM2(3), TPM3(2), TPM4(2), TTN(1152), VIM(6) 56716050 1717 236 1576 753 1250 124 57 148 120 18 6.48e-07 1.000 1.000 65 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 137 ACTA1(4), ACTA2(5), ADCY1(34), ADCY2(10), ADCY3(3), ADCY4(5), ADCY5(19), ADCY6(9), ADCY7(13), ADCY8(54), ADCY9(11), ADM(1), ARRB1(4), ARRB2(7), ATF1(5), ATF2(6), ATF3(1), ATF4(9), ATF5(9), ATP2A2(14), ATP2A3(15), CACNB3(3), CALCA(3), CALM1(1), CALM2(1), CAMK2A(6), CAMK2B(6), CAMK2D(6), CAMK2G(5), CNN1(8), CNN2(3), CORIN(29), CRHR1(7), DGKZ(9), ETS2(8), FOS(2), GABPA(6), GABPB2(8), GBA2(2), GJA1(10), GNAQ(6), GNB1(1), GNB2(1), GNB3(7), GNB4(4), GNB5(2), GNG2(3), GNG4(3), GNG7(2), GRK4(10), GRK5(5), GRK6(3), GSTO1(3), GUCA2A(2), GUCA2B(2), GUCY1A3(33), IGFBP1(3), IGFBP2(2), IGFBP3(3), IGFBP6(2), IL1B(8), IL6(2), ITPR1(36), ITPR2(20), ITPR3(12), JUN(1), MIB1(6), MYL2(9), MYL4(6), MYLK2(13), NFKB1(6), NOS1(77), NOS3(20), OXTR(6), PDE4B(8), PDE4D(7), PKIA(3), PKIB(1), PKIG(1), PLCB3(4), PLCD1(3), PLCG1(9), PLCG2(30), PRKACA(3), PRKACB(4), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCA(9), PRKCD(5), PRKCE(7), PRKCH(9), PRKCQ(21), PRKCZ(3), PRKD1(9), RAMP1(1), RAMP2(1), RAMP3(2), RGS1(5), RGS11(4), RGS14(3), RGS16(3), RGS18(8), RGS2(2), RGS20(2), RGS3(16), RGS4(4), RGS5(4), RGS6(20), RGS7(41), RGS9(16), RLN1(2), RYR1(114), RYR2(99), RYR3(96), SFN(2), SLC8A1(35), SP1(5), TNXB(126), USP5(8), YWHAB(1), YWHAQ(3) 73822322 1452 232 1376 861 1004 117 52 107 165 7 0.0159 1.000 1.000 66 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 162 ADORA1(5), ADORA2A(3), ADORA2B(1), ADORA3(12), ADRA1A(13), ADRA1B(5), ADRA1D(4), ADRA2A(3), ADRA2C(2), ADRB1(5), ADRB2(4), AGTR1(10), AGTR2(10), AVPR1A(4), AVPR1B(13), BDKRB1(6), BDKRB2(10), BRS3(5), C3AR1(6), CCKAR(12), CCKBR(11), CCR1(10), CCR10(2), CCR2(17), CCR3(11), CCR4(9), CCR5(10), CCR6(4), CCR7(4), CCR8(8), CCR9(6), CCRL2(6), CHML(5), CHRM1(5), CHRM2(26), CHRM3(26), CHRM4(6), CHRM5(7), CMKLR1(16), CNR1(12), CNR2(6), CX3CR1(16), CXCR3(4), CXCR4(3), DRD1(9), DRD2(16), DRD3(5), DRD4(1), DRD5(25), EDNRA(11), EDNRB(7), F2R(8), F2RL1(9), F2RL2(8), F2RL3(5), FPR1(22), FSHR(21), GALR1(5), GALR3(2), GALT(2), GHSR(11), GNB2L1(4), GPR17(1), GPR173(1), GPR174(12), GPR27(2), GPR3(3), GPR35(6), GPR37(10), GPR37L1(7), GPR4(5), GPR50(19), GPR6(7), GPR63(9), GPR83(14), GPR85(5), GPR87(6), GRPR(7), HCRTR1(2), HCRTR2(34), HRH1(15), HRH2(3), HRH3(5), HTR1A(11), HTR1B(2), HTR1D(7), HTR1E(7), HTR1F(9), HTR2A(11), HTR2B(2), HTR2C(14), HTR4(8), HTR5A(19), HTR6(3), HTR7(10), LHCGR(29), LTB4R(1), MAS1(4), MC1R(1), MC3R(7), MC4R(1), MC5R(8), MLNR(2), MTNR1A(10), MTNR1B(8), NMBR(8), NMUR1(7), NMUR2(16), NPY1R(29), NPY2R(13), NPY5R(25), NTSR1(8), NTSR2(2), OPN1SW(3), OPN3(4), OPRD1(3), OPRK1(23), OPRL1(8), OPRM1(5), OR10A5(10), OR11A1(6), OR12D3(9), OR1C1(14), OR1F1(8), OR1Q1(6), OR2H1(12), OR5V1(12), OR7A5(2), OR7C1(3), OR8B8(14), OXTR(6), P2RY1(5), P2RY10(7), P2RY11(2), P2RY12(4), P2RY13(4), P2RY14(8), P2RY2(10), P2RY6(2), PTAFR(2), PTGDR(12), PTGER2(7), PTGER4(3), PTGFR(21), PTGIR(5), RGR(8), RHO(2), RRH(2), SSTR1(10), SSTR2(7), SSTR3(13), SSTR4(4), SUCNR1(10), TBXA2R(4), TRHR(24) 51650384 1313 228 1224 996 888 135 48 138 103 1 0.00262 1.000 1.000 67 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 151 AKT1(4), AKT2(8), AKT3(3), CBL(10), CBLB(21), CBLC(16), CCND1(2), CCND2(7), CCND3(2), CISH(4), CLCF1(1), CNTF(2), CNTFR(4), CREBBP(24), CRLF2(8), CSF2(2), CSF2RA(23), CSF2RB(24), CSF3(4), CSF3R(10), EP300(19), EPO(5), EPOR(1), GH1(5), GH2(7), GHR(43), GRB2(2), IFNA1(1), IFNA10(2), IFNA13(1), IFNA14(8), IFNA16(11), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA5(4), IFNA6(3), IFNA7(6), IFNA8(3), IFNAR1(3), IFNAR2(8), IFNB1(6), IFNG(4), IFNGR1(3), IFNGR2(4), IFNK(2), IFNW1(4), IL10(2), IL10RA(9), IL10RB(7), IL11(3), IL11RA(3), IL12A(4), IL12B(3), IL12RB1(15), IL12RB2(3), IL13(2), IL13RA1(4), IL13RA2(6), IL15(3), IL15RA(6), IL19(2), IL2(4), IL20(4), IL20RA(11), IL21(6), IL21R(19), IL22(2), IL22RA1(13), IL22RA2(3), IL23A(2), IL23R(8), IL26(4), IL2RA(7), IL2RB(12), IL2RG(3), IL3(3), IL3RA(8), IL4(1), IL4R(18), IL5(4), IL5RA(16), IL6(2), IL6R(3), IL6ST(11), IL7(5), IL7R(37), IL9(1), IL9R(6), IRF9(2), JAK1(7), JAK2(8), JAK3(11), LEP(4), LEPR(31), LIF(1), LIFR(39), MPL(9), MYC(5), OSM(5), OSMR(40), PIAS1(7), PIAS2(5), PIAS3(6), PIAS4(1), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(3), PIK3R2(6), PIK3R3(2), PIK3R5(17), PIM1(1), PRL(3), PRLR(37), PTPN11(10), PTPN6(5), SOCS1(1), SOCS2(2), SOCS3(1), SOCS4(3), SOCS5(8), SOCS7(5), SOS1(10), SOS2(13), SPRED1(6), SPRED2(4), SPRY1(10), SPRY2(3), SPRY3(12), SPRY4(1), STAM(6), STAM2(3), STAT1(5), STAT2(6), STAT3(11), STAT4(26), STAT5A(3), STAT5B(5), STAT6(9), TPO(47), TSLP(2), TYK2(8) 61933245 1161 228 1115 577 750 96 38 131 144 2 0.0918 1.000 1.000 68 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 89 ADCY1(34), ADCY2(10), ADCY3(3), ADCY4(5), ADCY5(19), ADCY6(9), ADCY7(13), ADCY8(54), ADCY9(11), ADRB1(5), CSNK1D(3), DRD1(9), DRD2(16), EGF(22), EGFR(25), GJA1(10), GJD2(5), GNA11(9), GNAI1(2), GNAI3(2), GNAQ(6), GNAS(33), GRB2(2), GRM1(13), GRM5(17), GUCY1A2(20), GUCY1A3(33), GUCY1B3(8), GUCY2C(38), GUCY2D(10), GUCY2F(21), HRAS(3), HTR2A(11), HTR2B(2), HTR2C(14), ITPR1(36), ITPR2(20), ITPR3(12), KRAS(7), MAP2K2(5), MAP2K5(5), MAP3K2(8), MAPK1(4), MAPK3(3), MAPK7(4), NPR1(17), NPR2(21), PDGFA(1), PDGFB(6), PDGFC(17), PDGFD(7), PDGFRA(32), PDGFRB(23), PLCB1(58), PLCB2(12), PLCB3(4), PLCB4(87), PRKACA(3), PRKACB(4), PRKACG(10), PRKCA(9), PRKCG(16), PRKG1(14), PRKG2(16), PRKX(3), RAF1(11), SOS1(10), SOS2(13), SRC(2), TJP1(16), TUBA1A(4), TUBA1B(4), TUBA1C(2), TUBA3C(24), TUBA3D(13), TUBA3E(4), TUBA4A(7), TUBA8(5), TUBAL3(13), TUBB(1), TUBB1(5), TUBB2A(2), TUBB3(4), TUBB6(10), TUBB8(11) 55209936 1122 223 1048 635 763 89 43 104 118 5 0.00871 1.000 1.000 69 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 141 APC(27), APC2(12), AXIN1(10), AXIN2(5), BTRC(4), CACYBP(2), CAMK2A(6), CAMK2B(6), CAMK2D(6), CAMK2G(5), CCND1(2), CCND2(7), CCND3(2), CER1(18), CHD8(30), CREBBP(24), CSNK1A1(5), CSNK1A1L(7), CSNK1E(5), CSNK2A1(2), CSNK2A2(1), CSNK2B(1), CTBP2(1), CTNNBIP1(1), CUL1(3), DAAM1(8), DAAM2(7), DKK1(3), DKK2(19), DKK4(4), DVL1(1), DVL2(3), DVL3(9), EP300(19), FBXW11(6), FZD1(5), FZD10(4), FZD2(7), FZD3(1), FZD4(1), FZD5(2), FZD6(2), FZD7(5), FZD8(6), FZD9(1), GSK3B(3), JUN(1), LEF1(3), LRP5(21), LRP6(14), MAP3K7(1), MAPK10(9), MAPK8(2), MAPK9(4), MMP7(4), MYC(5), NFAT5(11), NFATC1(17), NFATC2(12), NFATC3(11), NFATC4(18), NKD1(9), NKD2(7), NLK(5), PLCB1(58), PLCB2(12), PLCB3(4), PLCB4(87), PORCN(4), PPARD(3), PPP2CA(1), PPP2CB(2), PPP2R1A(4), PPP2R1B(5), PPP2R2A(5), PPP2R2B(6), PPP2R2C(8), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRICKLE1(11), PRICKLE2(6), PRKACA(3), PRKACB(4), PRKACG(10), PRKCA(9), PRKCG(16), PRKX(3), PSEN1(3), RAC2(1), RHOA(2), ROCK1(6), ROCK2(14), RUVBL1(1), SENP2(9), SFRP1(3), SFRP2(9), SFRP4(6), SFRP5(1), SMAD2(4), SMAD3(4), SMAD4(2), SOX17(8), TBL1X(4), TBL1XR1(3), TBL1Y(9), TCF7(1), TCF7L1(4), TCF7L2(7), VANGL1(3), VANGL2(8), WIF1(7), WNT1(2), WNT10A(7), WNT10B(6), WNT11(4), WNT16(4), WNT2(8), WNT2B(5), WNT3(5), WNT3A(8), WNT4(1), WNT5A(5), WNT5B(5), WNT6(3), WNT7A(13), WNT7B(6), WNT8A(6), WNT8B(8), WNT9A(4), WNT9B(6) 67229327 959 221 917 501 612 84 39 104 115 5 0.204 1.000 1.000 70 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 128 ACACA(23), ACACB(23), AKT1(4), AKT2(8), AKT3(3), ARAF(5), CALM1(1), CALM2(1), CALML3(9), CALML6(1), CBL(10), CBLB(21), CBLC(16), CRK(3), CRKL(2), EIF4EBP1(1), ELK1(3), EXOC7(8), FASN(25), FBP1(3), FBP2(2), FLOT1(1), FOXO1(6), G6PC(5), G6PC2(3), GCK(16), GRB2(2), GSK3B(3), GYS1(3), GYS2(24), HRAS(3), IKBKB(4), INPP5D(36), INSR(23), IRS1(5), IRS2(3), IRS4(11), KRAS(7), LIPE(10), MAP2K2(5), MAPK1(4), MAPK10(9), MAPK3(3), MAPK8(2), MAPK9(4), MKNK1(6), MKNK2(4), PCK1(25), PCK2(6), PDE3A(30), PDE3B(6), PDPK1(5), PFKL(3), PFKP(2), PHKA1(25), PHKA2(9), PHKB(10), PHKG1(3), PHKG2(3), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(3), PIK3R2(6), PIK3R3(2), PIK3R5(17), PKLR(14), PPARGC1A(26), PPP1CA(3), PPP1CB(5), PPP1CC(2), PPP1R3A(64), PPP1R3B(7), PPP1R3C(4), PPP1R3D(3), PRKAA1(1), PRKAA2(32), PRKAB1(2), PRKAB2(2), PRKACA(3), PRKACB(4), PRKACG(10), PRKAG1(3), PRKAG2(8), PRKAG3(11), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCI(8), PRKCZ(3), PRKX(3), PTPN1(4), PTPRF(35), PYGB(3), PYGL(9), PYGM(14), RAF1(11), RAPGEF1(14), RHEB(2), RHOQ(1), RPS6(1), RPS6KB1(4), RPS6KB2(2), SH2B2(4), SHC1(2), SHC2(7), SHC3(15), SHC4(4), SLC2A4(8), SOCS1(1), SOCS2(2), SOCS3(1), SOCS4(3), SORBS1(16), SOS1(10), SOS2(13), SREBF1(5), TRIP10(6), TSC1(9), TSC2(14) 66952032 1036 219 994 534 676 91 38 109 118 4 0.0652 1.000 1.000 71 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADA(3), ADCY1(34), ADCY2(10), ADCY3(3), ADCY4(5), ADCY5(19), ADCY6(9), ADCY7(13), ADCY8(54), ADCY9(11), ADK(5), ADSL(6), ADSS(2), ADSSL1(9), AK1(1), AK2(3), AK5(11), AK7(27), ALLC(8), AMPD1(34), AMPD2(8), AMPD3(29), APRT(3), ATIC(5), CANT1(11), DGUOK(4), ENPP1(13), ENPP3(14), ENTPD1(12), ENTPD2(4), ENTPD3(9), ENTPD4(3), ENTPD5(3), ENTPD6(4), ENTPD8(2), FHIT(2), GART(10), GDA(15), GMPR(2), GMPR2(1), GMPS(6), GUCY1A2(20), GUCY1A3(33), GUCY1B3(8), GUCY2C(38), GUCY2D(10), GUCY2F(21), GUK1(3), IMPDH1(4), ITPA(1), NME1(1), NME4(1), NME6(3), NME7(5), NPR1(17), NPR2(21), NT5C1A(6), NT5C1B(24), NT5C2(3), NT5E(6), NT5M(2), NUDT2(2), NUDT5(1), NUDT9(2), PAICS(1), PAPSS1(4), PAPSS2(5), PDE10A(13), PDE11A(20), PDE1A(44), PDE1C(54), PDE2A(16), PDE3B(6), PDE4A(10), PDE4B(8), PDE4C(19), PDE4D(7), PDE5A(9), PDE6D(2), PDE6G(2), PDE7A(1), PDE7B(17), PDE8A(3), PDE8B(22), PDE9A(12), PFAS(12), PKLR(14), PNPT1(2), POLA1(3), POLA2(9), POLD1(7), POLD2(2), POLD3(7), POLE(16), POLE2(2), POLR1A(13), POLR1B(8), POLR1C(1), POLR2A(13), POLR2B(14), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(2), POLR2H(2), POLR2J(2), POLR2L(1), POLR3A(8), POLR3B(15), POLR3G(1), POLR3GL(3), POLR3H(1), POLR3K(1), PRIM1(3), PRIM2(6), PRPS1(3), PRPS1L1(13), PRPS2(3), PRUNE(3), RRM1(3), RRM2(4), RRM2B(2), XDH(61) 69521955 1197 218 1136 613 816 94 53 111 121 2 0.00165 1.000 1.000 72 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 66 A2M(32), BDKRB1(6), BDKRB2(10), C1QA(6), C1QB(7), C1QC(10), C1R(16), C1S(20), C2(35), C3(55), C3AR1(6), C4BPA(16), C4BPB(6), C5(23), C5AR1(10), C6(72), C7(49), C8B(47), C8G(1), C9(22), CD46(1), CD55(6), CD59(1), CFB(20), CFH(50), CFI(18), CPB2(1), CR1(53), CR2(35), F10(8), F11(14), F12(1), F13A1(26), F13B(35), F2(13), F2R(8), F3(2), F5(39), F7(7), F8(49), F9(15), FGA(41), FGB(10), FGG(10), KLKB1(26), KNG1(14), MASP1(10), MASP2(11), MBL2(14), PLAT(5), PLAUR(4), PLG(36), PROC(11), PROS1(17), SERPINA1(9), SERPINA5(10), SERPINC1(7), SERPIND1(5), SERPINE1(6), SERPINF2(7), SERPING1(14), TFPI(7), THBD(2), VWF(59) 37951820 1186 218 1108 513 833 78 51 109 106 9 0.000147 1.000 1.000 73 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 83 ANPEP(25), CD14(6), CD19(8), CD1A(14), CD1B(14), CD1C(28), CD1D(10), CD1E(28), CD2(29), CD22(26), CD33(21), CD34(4), CD36(6), CD37(3), CD38(6), CD3D(7), CD3E(2), CD3G(1), CD4(9), CD44(5), CD5(8), CD55(6), CD59(1), CD7(2), CD8A(2), CD8B(9), CR1(53), CR2(35), CSF1(12), CSF1R(13), CSF2(2), CSF2RA(23), CSF3(4), CSF3R(10), DNTT(10), EPO(5), EPOR(1), FCER2(3), FCGR1A(6), FLT3(38), FLT3LG(1), GP5(6), GP9(6), HLA-DRA(13), HLA-DRB1(5), HLA-DRB5(1), IL11(3), IL11RA(3), IL1A(5), IL1B(8), IL1R1(12), IL1R2(7), IL2RA(7), IL3(3), IL3RA(8), IL4(1), IL4R(18), IL5(4), IL5RA(16), IL6(2), IL6R(3), IL7(5), IL7R(37), IL9R(6), ITGA1(23), ITGA2(13), ITGA2B(12), ITGA3(8), ITGA4(45), ITGA5(25), ITGA6(12), ITGAM(25), ITGB3(16), KIT(13), KITLG(10), MME(25), MS4A1(8), TFRC(4), THPO(10), TNF(1), TPO(47) 34627332 972 217 902 471 678 52 35 81 122 4 0.00485 1.000 1.000 74 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 79 AGL(18), AMY2A(7), AMY2B(14), ASCC3(16), ATP13A2(13), DDX18(5), DDX19A(1), DDX23(7), DDX4(13), DDX41(8), DDX47(1), DDX50(5), DDX51(5), DDX52(4), DDX54(3), DDX55(2), DDX56(3), DHX58(3), ENPP1(13), ENPP3(14), ENTPD7(2), EP400(28), ERCC2(3), ERCC3(6), G6PC(5), G6PC2(3), GAA(8), GANC(6), GBA(7), GBE1(9), GCK(16), GPI(3), GUSB(5), GYS1(3), GYS2(24), HK1(3), HK2(15), HK3(15), IFIH1(10), MGAM(169), MOV10L1(24), NUDT5(1), NUDT8(2), PGM1(6), PGM3(1), PYGB(3), PYGL(9), PYGM(14), RAD54B(8), RUVBL2(5), SETX(19), SI(94), SKIV2L2(6), SMARCA2(14), SMARCA5(5), TREH(2), UGDH(1), UGP2(1), UGT1A1(12), UGT1A10(18), UGT1A3(14), UGT1A4(10), UGT1A5(10), UGT1A6(15), UGT1A7(12), UGT1A9(16), UGT2A1(25), UGT2A3(32), UGT2B11(23), UGT2B15(31), UGT2B17(30), UGT2B28(29), UGT2B4(35), UGT2B7(19), UXS1(5) 51436338 1046 215 959 470 714 82 42 82 123 3 0.000226 1.000 1.000 75 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 69 ARAF(5), CACNA1A(38), CRHR1(7), GNA11(9), GNA12(3), GNA13(1), GNAI1(2), GNAI3(2), GNAO1(1), GNAQ(6), GNAS(33), GNAZ(7), GRIA1(47), GRIA2(43), GRIA3(26), GRID2(60), GRM1(13), GRM5(17), GUCY1A2(20), GUCY1A3(33), GUCY1B3(8), GUCY2C(38), GUCY2D(10), GUCY2F(21), HRAS(3), IGF1(11), IGF1R(15), ITPR1(36), ITPR2(20), ITPR3(12), KRAS(7), LYN(11), MAP2K2(5), MAPK1(4), MAPK3(3), NOS1(77), NOS3(20), NPR1(17), NPR2(21), PLA2G12B(3), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(19), PLA2G4A(16), PLA2G5(2), PLA2G6(13), PLCB1(58), PLCB2(12), PLCB3(4), PLCB4(87), PPP2CA(1), PPP2CB(2), PPP2R1A(4), PPP2R1B(5), PPP2R2A(5), PPP2R2B(6), PPP2R2C(8), PRKCA(9), PRKCG(16), PRKG1(14), PRKG2(16), RAF1(11), RYR1(114) 45089065 1156 214 1064 631 804 76 36 100 130 10 0.000809 1.000 1.000 76 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 68 ADH1A(17), ADH1B(30), ADH4(12), ADH5(3), ADH6(14), ADH7(16), ADHFE1(6), AKR1C1(2), AKR1C2(4), AKR1C3(12), AKR1C4(10), ALDH1A3(2), ALDH3A1(10), ALDH3B1(3), ALDH3B2(8), CYP1A1(10), CYP1A2(9), CYP1B1(4), CYP2B6(21), CYP2C18(34), CYP2C19(40), CYP2C8(32), CYP2C9(41), CYP2E1(14), CYP2F1(13), CYP2S1(14), CYP3A4(21), CYP3A43(19), CYP3A5(14), CYP3A7(18), DHDH(5), EPHX1(2), GSTA1(7), GSTA2(3), GSTA3(1), GSTA4(1), GSTA5(3), GSTK1(4), GSTM1(2), GSTM2(2), GSTM3(4), GSTM4(2), GSTM5(6), GSTO2(1), GSTP1(3), GSTT1(1), GSTZ1(1), MGST1(2), MGST2(2), MGST3(2), UGT1A1(12), UGT1A10(18), UGT1A3(14), UGT1A4(10), UGT1A5(10), UGT1A6(15), UGT1A7(12), UGT1A9(16), UGT2A1(25), UGT2A3(32), UGT2B11(23), UGT2B15(31), UGT2B17(30), UGT2B28(29), UGT2B4(35), UGT2B7(19) 23480328 838 211 752 365 598 52 37 53 95 3 2.85e-09 1.000 1.000 77 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(16), ABCA10(24), ABCA12(80), ABCA13(80), ABCA2(14), ABCA3(16), ABCA4(58), ABCA5(12), ABCA6(30), ABCA7(18), ABCA8(37), ABCA9(22), ABCB1(39), ABCB10(7), ABCB11(49), ABCB4(21), ABCB5(52), ABCB6(2), ABCB7(6), ABCB8(3), ABCB9(7), ABCC1(15), ABCC10(15), ABCC11(19), ABCC12(26), ABCC2(12), ABCC3(30), ABCC4(14), ABCC5(12), ABCC6(29), ABCC8(44), ABCC9(62), ABCD1(1), ABCD2(22), ABCD3(11), ABCD4(3), ABCG1(12), ABCG2(5), ABCG4(7), ABCG5(6), ABCG8(13), CFTR(62), TAP1(2), TAP2(7) 50128219 1022 210 961 581 673 82 34 108 119 6 0.00553 1.000 1.000 78 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 64 ADCY1(34), ADCY8(54), ARAF(5), ATF4(9), CACNA1C(60), CALM1(1), CALM2(1), CALML3(9), CALML6(1), CAMK2A(6), CAMK2B(6), CAMK2D(6), CAMK2G(5), CAMK4(17), CREBBP(24), EP300(19), GNAQ(6), GRIA1(47), GRIA2(43), GRIN1(8), GRIN2A(107), GRIN2B(59), GRIN2C(10), GRIN2D(11), GRM1(13), GRM5(17), HRAS(3), ITPR1(36), ITPR2(20), ITPR3(12), KRAS(7), MAP2K2(5), MAPK1(4), MAPK3(3), PLCB1(58), PLCB2(12), PLCB3(4), PLCB4(87), PPP1CA(3), PPP1CB(5), PPP1CC(2), PPP1R12A(4), PPP1R1A(4), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKACA(3), PRKACB(4), PRKACG(10), PRKCA(9), PRKCG(16), PRKX(3), RAF1(11), RAP1A(1), RAP1B(1), RAPGEF3(14), RPS6KA1(9), RPS6KA2(6), RPS6KA3(2), RPS6KA6(21) 40787458 968 210 900 578 646 82 39 95 100 6 0.256 1.000 1.000 79 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 88 AKT1(4), AKT3(3), BCAR1(5), CAPN1(5), CAPN10(7), CAPN11(10), CAPN2(6), CAPN3(9), CAPN5(6), CAPN6(14), CAPN7(2), CAPN9(12), CAPNS1(2), CAV1(1), CAV3(2), CDC42(2), CRK(3), CSK(1), DOCK1(17), FYN(8), GIT2(8), GRB2(2), ILK(2), ITGA10(12), ITGA11(19), ITGA2(13), ITGA2B(12), ITGA3(8), ITGA4(45), ITGA5(25), ITGA6(12), ITGA7(25), ITGA8(39), ITGA9(15), ITGAD(31), ITGAE(21), ITGAL(27), ITGAM(25), ITGAV(11), ITGAX(25), ITGB1(4), ITGB2(17), ITGB3(16), ITGB4(22), ITGB5(9), ITGB6(11), ITGB7(7), ITGB8(19), MAP2K2(5), MAP2K3(9), MAP2K6(3), MAPK10(9), MAPK12(1), MAPK4(17), MAPK6(8), MAPK7(4), MYLK2(13), PAK1(4), PAK2(9), PAK3(10), PAK4(8), PAK6(6), PDPK1(5), PIK3R2(6), PTK2(7), PXN(2), RAC2(1), RAP1B(1), RAPGEF1(14), RHO(2), ROCK1(6), ROCK2(14), SDCCAG8(3), SEPP1(3), SHC1(2), SHC3(15), SORBS1(16), SOS1(10), SRC(2), TLN1(12), TNS1(11), VASP(3), VAV2(5), VAV3(11), VCL(9), ZYX(8) 56054100 875 209 849 470 562 71 34 114 90 4 0.191 1.000 1.000 80 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 72 CALM1(1), CALM2(1), CALML3(9), CALML6(1), CDS1(11), CDS2(5), DGKA(3), DGKB(29), DGKD(13), DGKE(8), DGKG(18), DGKH(12), DGKI(36), DGKQ(7), DGKZ(9), IMPA1(1), IMPA2(5), INPP1(3), INPP4A(7), INPP4B(4), INPP5A(5), INPP5B(7), INPP5D(36), INPPL1(16), ITPK1(6), ITPKB(11), ITPR1(36), ITPR2(20), ITPR3(12), OCRL(7), PI4KA(22), PI4KB(8), PIK3C2A(8), PIK3C2B(16), PIK3C2G(56), PIK3C3(3), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(3), PIK3R2(6), PIK3R3(2), PIK3R5(17), PIP4K2A(6), PIP4K2B(3), PIP4K2C(2), PIP5K1A(6), PIP5K1B(21), PIP5K1C(9), PLCB1(58), PLCB2(12), PLCB3(4), PLCB4(87), PLCD1(3), PLCD3(4), PLCD4(5), PLCE1(56), PLCG1(9), PLCG2(30), PLCZ1(30), PRKCA(9), PRKCG(16), SYNJ1(23), SYNJ2(22) 52369739 951 208 879 458 665 50 38 82 110 6 0.000114 1.000 1.000 81 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 107 ACTN1(8), ACTN2(21), ACTN4(5), ARHGAP5(13), BCAR1(5), CD99(1), CDC42(2), CDH5(12), CLDN1(5), CLDN10(8), CLDN11(5), CLDN14(5), CLDN15(1), CLDN16(7), CLDN17(5), CLDN18(11), CLDN19(2), CLDN2(6), CLDN20(1), CLDN22(2), CLDN3(3), CLDN4(12), CLDN6(9), CLDN7(1), CLDN8(4), CLDN9(1), CTNNA1(3), CTNNA2(28), CTNNA3(39), CTNND1(9), CXCL12(2), CXCR4(3), CYBA(1), CYBB(8), ESAM(5), EZR(7), F11R(7), GNAI1(2), GNAI3(2), ICAM1(2), ITGA4(45), ITGAL(27), ITGAM(25), ITGB1(4), ITGB2(17), ITK(25), JAM2(11), JAM3(3), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MLLT4(17), MMP2(9), MMP9(8), MSN(2), MYL2(9), MYL5(1), MYL7(3), MYL9(2), NCF1(3), NCF2(8), NCF4(5), NOX1(13), NOX3(7), OCLN(6), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(3), PIK3R2(6), PIK3R3(2), PIK3R5(17), PLCG1(9), PLCG2(30), PRKCA(9), PRKCG(16), PTK2(7), PTK2B(12), PTPN11(10), PXN(2), RAC2(1), RAP1A(1), RAP1B(1), RAPGEF3(14), RAPGEF4(19), RASSF5(4), RHOA(2), RHOH(5), ROCK1(6), ROCK2(14), SIPA1(9), THY1(1), TXK(10), VASP(3), VAV1(19), VAV2(5), VAV3(11), VCAM1(17), VCL(9) 51462678 865 208 826 467 574 64 25 95 102 5 0.0355 1.000 1.000 82 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 93 ADCY1(34), ADCY2(10), ADCY3(3), ADCY4(5), ADCY5(19), ADCY6(9), ADCY7(13), ADCY8(54), ADCY9(11), ATF4(9), CACNA1C(60), CACNA1D(36), CACNA1F(24), CACNA1S(54), CALM1(1), CALM2(1), CALML3(9), CALML6(1), CAMK2A(6), CAMK2B(6), CAMK2D(6), CAMK2G(5), CDC42(2), CGA(1), EGFR(25), ELK1(3), FSHB(9), GNA11(9), GNAQ(6), GNAS(33), GNRH2(2), GNRHR(2), GRB2(2), HBEGF(1), HRAS(3), ITPR1(36), ITPR2(20), ITPR3(12), JUN(1), KRAS(7), LHB(1), MAP2K2(5), MAP2K3(9), MAP2K4(4), MAP2K6(3), MAP2K7(5), MAP3K1(4), MAP3K2(8), MAP3K3(8), MAP3K4(19), MAPK1(4), MAPK10(9), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MAPK3(3), MAPK7(4), MAPK8(2), MAPK9(4), MMP14(3), MMP2(9), PLA2G12B(3), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(19), PLA2G4A(16), PLA2G5(2), PLA2G6(13), PLCB1(58), PLCB2(12), PLCB3(4), PLCB4(87), PLD1(14), PLD2(8), PRKACA(3), PRKACB(4), PRKACG(10), PRKCA(9), PRKCD(5), PRKX(3), PTK2B(12), RAF1(11), SOS1(10), SOS2(13), SRC(2) 53196332 1003 207 947 625 647 95 46 97 113 5 0.378 1.000 1.000 83 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 108 A4GNT(2), ALG1(4), ALG10(6), ALG10B(4), ALG11(5), ALG12(1), ALG13(10), ALG14(2), ALG2(5), ALG3(4), ALG6(2), ALG8(7), ALG9(5), B3GNT1(3), B3GNT2(2), B3GNT6(2), B3GNT7(6), B4GALT1(2), B4GALT2(2), B4GALT3(3), B4GALT4(3), B4GALT5(3), C1GALT1(7), C1GALT1C1(3), CHPF(4), CHST1(11), CHST11(7), CHST12(7), CHST13(3), CHST14(3), CHST2(5), CHST3(2), CHST4(10), CHST6(4), CHST7(3), CHSY1(9), DAD1(1), DDOST(2), DPAGT1(2), EXT1(2), EXT2(9), EXTL1(4), EXTL3(13), FUT11(4), FUT8(8), GALNT1(4), GALNT10(7), GALNT11(3), GALNT12(8), GALNT13(31), GALNT14(30), GALNT2(7), GALNT3(4), GALNT4(5), GALNT5(13), GALNT6(16), GALNT7(4), GALNT8(28), GALNT9(7), GALNTL5(17), GANAB(6), GCNT1(6), GCNT3(8), GCNT4(3), HS2ST1(1), HS3ST1(11), HS3ST2(8), HS3ST3A1(6), HS3ST3B1(1), HS3ST5(9), HS6ST1(2), HS6ST2(3), HS6ST3(15), MAN1A1(19), MAN1A2(7), MAN1B1(4), MAN1C1(11), MAN2A1(10), MGAT1(3), MGAT2(3), MGAT3(12), MGAT4A(8), MGAT4B(1), MGAT5(6), MGAT5B(11), NDST1(6), NDST2(2), NDST3(25), NDST4(51), OGT(9), RPN2(4), ST3GAL1(8), ST3GAL2(1), ST3GAL3(2), ST3GAL4(1), ST6GAL1(8), ST6GALNAC1(8), STT3B(5), WBSCR17(46), XYLT1(12), XYLT2(5) 46699723 757 200 727 406 486 64 34 77 96 0 0.0611 1.000 1.000 84 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 107 ABL1(15), ANAPC1(18), ANAPC10(1), ANAPC2(7), ANAPC4(6), ANAPC5(5), ANAPC7(6), ATM(16), ATR(22), BUB1(6), BUB1B(10), BUB3(1), CCNA1(16), CCNB2(2), CCNB3(31), CCND1(2), CCND2(7), CCND3(2), CCNE1(4), CCNE2(6), CCNH(1), CDC14A(6), CDC14B(3), CDC20(1), CDC23(4), CDC25A(8), CDC25B(4), CDC25C(5), CDC27(14), CDC6(2), CDC7(3), CDK2(1), CDK6(2), CDK7(2), CDKN1A(3), CDKN1B(1), CDKN2C(1), CHEK1(2), CHEK2(2), CREBBP(24), CUL1(3), DBF4(6), E2F1(6), E2F2(5), E2F3(4), EP300(19), ESPL1(19), FZR1(8), GADD45B(2), GSK3B(3), HDAC1(2), HDAC2(2), MAD1L1(6), MAD2L1(1), MAD2L2(2), MCM2(11), MCM3(9), MCM4(8), MCM5(5), MCM6(5), MCM7(1), MDM2(4), PCNA(2), PKMYT1(3), PLK1(4), PRKDC(22), PTTG1(1), RB1(10), RBL1(14), RBL2(6), SFN(2), SKP2(2), SMAD2(4), SMAD3(4), SMAD4(2), SMC1A(3), SMC1B(25), TFDP1(2), TGFB1(2), TGFB2(3), TGFB3(3), WEE1(2), YWHAB(1), YWHAE(2), YWHAG(2), YWHAQ(3) 57189963 527 199 518 241 304 48 36 81 56 2 0.193 1.000 1.000 85 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 95 ADCY1(34), ADCY2(10), ADCY3(3), ADCY4(5), ADCY5(19), ADCY6(9), ADCY7(13), ADCY8(54), ADCY9(11), ASIP(1), CALM1(1), CALM2(1), CALML3(9), CALML6(1), CAMK2A(6), CAMK2B(6), CAMK2D(6), CAMK2G(5), CREB3L1(7), CREB3L2(11), CREB3L3(10), CREB3L4(7), CREBBP(24), DCT(4), DVL1(1), DVL2(3), DVL3(9), EDN1(9), EDNRB(7), EP300(19), FZD1(5), FZD10(4), FZD2(7), FZD3(1), FZD4(1), FZD5(2), FZD6(2), FZD7(5), FZD8(6), FZD9(1), GNAI1(2), GNAI3(2), GNAO1(1), GNAQ(6), GNAS(33), GSK3B(3), HRAS(3), KIT(13), KITLG(10), KRAS(7), LEF1(3), MAP2K2(5), MAPK1(4), MAPK3(3), MC1R(1), MITF(6), PLCB1(58), PLCB2(12), PLCB3(4), PLCB4(87), POMC(4), PRKACA(3), PRKACB(4), PRKACG(10), PRKCA(9), PRKCG(16), PRKX(3), RAF1(11), TCF7(1), TCF7L1(4), TCF7L2(7), TYR(11), TYRP1(9), WNT1(2), WNT10A(7), WNT10B(6), WNT11(4), WNT16(4), WNT2(8), WNT2B(5), WNT3(5), WNT3A(8), WNT4(1), WNT5A(5), WNT5B(5), WNT6(3), WNT7A(13), WNT7B(6), WNT8A(6), WNT8B(8), WNT9A(4), WNT9B(6) 44573769 800 199 750 458 505 78 42 82 89 4 0.0865 1.000 1.000 86 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 75 ABL1(15), ACTN1(8), ACTR2(3), ACTR3(2), AKT1(4), AKT2(8), AKT3(3), ANGPTL2(3), ARHGEF6(11), ARHGEF7(5), BCAR1(5), CAV1(1), CDC42(2), CRK(3), CSE1L(5), DOCK1(17), EPHB2(36), FYN(8), GRB2(2), GRB7(9), ILK(2), ITGA1(23), ITGA10(12), ITGA11(19), ITGA2(13), ITGA3(8), ITGA4(45), ITGA5(25), ITGA6(12), ITGA7(25), ITGA8(39), ITGA9(15), ITGB3BP(3), MAP2K4(4), MAP2K7(5), MAP3K11(6), MAPK1(4), MAPK10(9), MAPK8(2), MAPK8IP1(7), MAPK8IP2(8), MAPK8IP3(9), MAPK9(4), MRAS(2), MYLK(48), MYLK2(13), P4HB(3), PAK1(4), PAK2(9), PAK3(10), PAK4(8), PAK6(6), PAK7(55), PIK3CA(10), PIK3CB(10), PKLR(14), PLCG1(9), PLCG2(30), PTK2(7), RAF1(11), RALA(1), RHO(2), ROCK1(6), ROCK2(14), SHC1(2), SOS1(10), SOS2(13), SRC(2), TERF2IP(2), TLN1(12), TLN2(27), VASP(3), WAS(8), ZYX(8) 50580065 808 199 768 415 517 68 29 108 84 2 0.129 1.000 1.000 87 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 90 ADCY1(34), ADCY2(10), ADCY3(3), ADCY4(5), ADCY5(19), ADCY6(9), ADCY7(13), ADCY8(54), ADCY9(11), AKAP1(12), AKAP10(3), AKAP11(12), AKAP12(6), AKAP2(2), AKAP3(17), AKAP4(19), AKAP6(41), AKAP7(3), AKAP8(7), AKAP9(37), ARHGEF1(1), CALM1(1), CALM2(1), CHMP1B(1), GNA11(9), GNA12(3), GNA13(1), GNA14(7), GNA15(7), GNAI3(2), GNAL(2), GNAO1(1), GNAQ(6), GNAZ(7), GNB1(1), GNB2(1), GNB3(7), GNB5(2), GNG10(1), GNG4(3), GNG7(2), GNGT2(5), HRAS(3), ITPR1(36), KCNJ3(21), KRAS(7), PALM2(3), PDE1A(44), PDE1B(15), PDE1C(54), PDE4A(10), PDE4B(8), PDE4C(19), PDE4D(7), PDE7A(1), PDE7B(17), PDE8A(3), PDE8B(22), PLCB3(4), PPP3CA(5), PPP3CC(2), PRKACA(3), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCA(9), PRKCD(5), PRKCE(7), PRKCG(16), PRKCH(9), PRKCI(8), PRKCQ(21), PRKCZ(3), PRKD1(9), PRKD3(9), RHOA(2), RRAS(1), SLC9A1(5), USP5(8) 49261196 811 198 773 493 556 60 37 76 82 0 0.645 1.000 1.000 88 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADA(3), ADCY1(34), ADCY2(10), ADCY3(3), ADCY4(5), ADCY5(19), ADCY6(9), ADCY7(13), ADCY8(54), ADK(5), ADSL(6), ADSS(2), AK1(1), AK2(3), AK5(11), ALLC(8), AMPD1(34), AMPD2(8), AMPD3(29), APRT(3), ATIC(5), ATP1B1(2), ATP5A1(2), ATP5B(1), ATP5C1(3), ATP5F1(7), ATP5G2(2), ATP5H(2), ATP5J(2), CANT1(11), DGUOK(4), ENPP1(13), ENPP3(14), ENTPD1(12), ENTPD2(4), FHIT(2), GART(10), GDA(15), GMPS(6), GUCY1A2(20), GUCY1A3(33), GUCY1B3(8), GUCY2C(38), GUCY2D(10), GUCY2F(21), GUK1(3), IMPDH1(4), ITPA(1), NME1(1), NPR1(17), NPR2(21), NT5E(6), NT5M(2), NUDT2(2), PAICS(1), PAPSS1(4), PAPSS2(5), PDE1A(44), PDE4A(10), PDE4B(8), PDE4C(19), PDE4D(7), PDE5A(9), PDE6B(16), PDE6C(25), PDE6G(2), PDE7B(17), PDE8A(3), PDE9A(12), PFAS(12), PKLR(14), POLB(1), POLD1(7), POLD2(2), POLE(16), POLG(8), POLL(10), POLQ(26), POLR1B(8), POLR2A(13), POLR2B(14), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(2), POLR2H(2), POLR2J(2), POLR2L(1), POLRMT(4), PRPS1(3), PRPS1L1(13), PRPS2(3), PRUNE(3), RRM1(3), RRM2(4) 54462095 920 197 864 484 625 74 33 90 96 2 0.00771 1.000 1.000 89 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 96 AKT1(4), AKT2(8), AKT3(3), CASP8(9), CD14(6), CD40(4), CD80(4), CD86(25), CHUK(2), CXCL10(3), CXCL11(1), CXCL9(2), FOS(2), IFNA1(1), IFNA10(2), IFNA13(1), IFNA14(8), IFNA16(11), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA5(4), IFNA6(3), IFNA7(6), IFNA8(3), IFNAR1(3), IFNAR2(8), IFNB1(6), IKBKB(4), IKBKE(9), IL12A(4), IL12B(3), IL1B(8), IL6(2), IRAK1(5), IRAK4(3), IRF3(3), IRF5(5), IRF7(5), JUN(1), LBP(10), LY96(4), MAP2K2(5), MAP2K3(9), MAP2K4(4), MAP2K6(3), MAP2K7(5), MAP3K7(1), MAPK1(4), MAPK10(9), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MAPK3(3), MAPK8(2), MAPK9(4), MYD88(1), NFKB1(6), NFKB2(5), NFKBIA(2), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(3), PIK3R2(6), PIK3R3(2), PIK3R5(17), RELA(4), RIPK1(3), SPP1(7), STAT1(5), TBK1(3), TICAM1(8), TIRAP(1), TLR1(15), TLR2(15), TLR3(11), TLR4(42), TLR5(22), TLR6(7), TLR7(17), TLR8(14), TLR9(14), TNF(1), TOLLIP(1), TRAF3(5), TRAF6(4) 37641714 564 195 544 292 365 40 27 69 61 2 0.0717 1.000 1.000 90 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 90 AKT1(4), AKT2(8), AKT3(3), BCL10(3), CARD11(41), CBL(10), CBLB(21), CBLC(16), CD247(4), CD28(2), CD3D(7), CD3E(2), CD3G(1), CD4(9), CD40LG(1), CD8A(2), CD8B(9), CDC42(2), CHUK(2), CSF2(2), CTLA4(2), FOS(2), FYN(8), GRAP2(6), GRB2(2), HRAS(3), ICOS(3), IFNG(4), IKBKB(4), IL10(2), IL2(4), IL4(1), IL5(4), ITK(25), JUN(1), KRAS(7), LAT(3), LCK(15), LCP2(8), MALT1(8), NCK1(2), NCK2(4), NFAT5(11), NFATC1(17), NFATC2(12), NFATC3(11), NFATC4(18), NFKB1(6), NFKB2(5), NFKBIA(2), NFKBIB(1), PAK1(4), PAK2(9), PAK3(10), PAK4(8), PAK6(6), PAK7(55), PDCD1(4), PDK1(2), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(3), PIK3R2(6), PIK3R3(2), PIK3R5(17), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKCQ(21), PTPN6(5), PTPRC(36), RASGRP1(11), RHOA(2), SOS1(10), SOS2(13), TEC(13), TNF(1), VAV1(19), VAV2(5), VAV3(11), ZAP70(8) 42739556 707 194 675 347 444 57 28 85 88 5 0.160 1.000 1.000 91 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 73 ACP1(4), ACTB(9), ACTG1(7), ACTN1(8), ACTN2(21), ACTN4(5), ACVR1B(3), ACVR1C(10), BAIAP2(8), CDC42(2), CDH1(6), CREBBP(24), CSNK2A1(2), CSNK2A2(1), CSNK2B(1), CTNNA1(3), CTNNA2(28), CTNNA3(39), CTNND1(9), EGFR(25), EP300(19), ERBB2(10), FARP2(7), FER(3), FGFR1(12), FYN(8), IGF1R(15), INSR(23), IQGAP1(10), LEF1(3), LMO7(30), MAP3K7(1), MAPK1(4), MAPK3(3), MET(23), MLLT4(17), NLK(5), PARD3(20), PTPN1(4), PTPN6(5), PTPRB(84), PTPRF(35), PTPRJ(9), PTPRM(8), PVRL1(4), PVRL2(6), PVRL3(5), PVRL4(10), RAC2(1), RHOA(2), SMAD2(4), SMAD3(4), SMAD4(2), SNAI1(2), SNAI2(4), SORBS1(16), SRC(2), SSX2IP(4), TCF7(1), TCF7L1(4), TCF7L2(7), TGFBR2(9), TJP1(16), VCL(9), WAS(8), WASF1(5), WASF2(6), WASF3(14), WASL(4), YES1(4) 50272712 726 193 691 377 479 62 28 73 79 5 0.351 1.000 1.000 92 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(18), AMY2A(7), AMY2B(14), ENPP1(13), ENPP3(14), G6PC(5), GAA(8), GANAB(6), GBE1(9), GCK(16), GPI(3), GUSB(5), GYS1(3), GYS2(24), HK1(3), HK2(15), HK3(15), MGAM(169), PGM1(6), PGM3(1), PYGB(3), PYGL(9), PYGM(14), SI(94), UCHL1(5), UCHL3(2), UGDH(1), UGT1A1(12), UGT1A10(18), UGT1A3(14), UGT1A4(10), UGT1A5(10), UGT1A6(15), UGT1A7(12), UGT1A9(16), UGT2B15(31), UGT2B4(35), UXS1(5) 24148111 660 193 598 290 460 61 26 47 64 2 0.000238 1.000 1.000 93 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 88 ACVR1(2), ACVR1B(3), ACVR1C(10), ACVR2A(5), ACVR2B(3), ACVRL1(11), AMHR2(15), BMP2(7), BMP4(5), BMP5(33), BMP6(12), BMP7(5), BMP8A(2), BMP8B(1), BMPR1A(2), BMPR1B(4), BMPR2(7), CHRD(21), COMP(8), CREBBP(24), CUL1(3), DCN(19), E2F4(3), E2F5(3), EP300(19), FST(5), GDF5(16), GDF6(2), GDF7(1), ID1(1), ID2(2), IFNG(4), INHBA(20), INHBB(9), INHBC(13), INHBE(5), LEFTY1(7), LEFTY2(4), LTBP1(46), MAPK1(4), MAPK3(3), MYC(5), NODAL(2), NOG(2), PITX2(6), PPP2CA(1), PPP2CB(2), PPP2R1A(4), PPP2R1B(5), PPP2R2A(5), PPP2R2B(6), PPP2R2C(8), RBL1(14), RBL2(6), RHOA(2), ROCK1(6), ROCK2(14), RPS6KB1(4), RPS6KB2(2), SMAD1(5), SMAD2(4), SMAD3(4), SMAD4(2), SMAD5(2), SMAD6(7), SMAD7(1), SMAD9(12), SMURF1(2), SMURF2(9), SP1(5), TFDP1(2), TGFB1(2), TGFB2(3), TGFB3(3), TGFBR2(9), THBS1(31), THBS2(14), THBS3(12), THBS4(19), TNF(1), ZFYVE16(7), ZFYVE9(8) 42268096 627 192 598 290 396 60 30 62 79 0 0.0723 1.000 1.000 94 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 122 ARAF(5), CASP3(2), CD244(10), CD247(4), CD48(5), CSF2(2), FAS(5), FASLG(15), FCER1G(1), FCGR3A(9), FYN(8), GRB2(2), GZMB(3), HLA-A(4), HLA-B(6), HLA-C(2), HLA-E(1), HLA-G(5), HRAS(3), ICAM1(2), ICAM2(4), IFNA1(1), IFNA10(2), IFNA13(1), IFNA14(8), IFNA16(11), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA5(4), IFNA6(3), IFNA7(6), IFNA8(3), IFNAR1(3), IFNAR2(8), IFNB1(6), IFNG(4), IFNGR1(3), IFNGR2(4), ITGAL(27), ITGB2(17), KIR2DL3(5), KIR3DL1(14), KIR3DL2(16), KLRC1(4), KLRC2(1), KLRC3(12), KLRD1(7), KLRK1(7), KRAS(7), LAT(3), LCK(15), LCP2(8), MAP2K2(5), MAPK1(4), MAPK3(3), MICA(4), MICB(7), NCR1(18), NCR2(14), NCR3(5), NFAT5(11), NFATC1(17), NFATC2(12), NFATC3(11), NFATC4(18), PAK1(4), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(3), PIK3R2(6), PIK3R3(2), PIK3R5(17), PLCG1(9), PLCG2(30), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRF1(14), PRKCA(9), PRKCG(16), PTK2B(12), PTPN11(10), PTPN6(5), RAC2(1), RAF1(11), SH2D1A(3), SH2D1B(5), SH3BP2(2), SHC1(2), SHC2(7), SHC3(15), SHC4(4), SOS1(10), SOS2(13), SYK(15), TNF(1), TNFRSF10A(7), TNFRSF10B(5), TNFRSF10C(4), TNFRSF10D(9), TNFSF10(9), TYROBP(4), ULBP1(2), ULBP2(1), ULBP3(6), VAV1(19), VAV2(5), VAV3(11), ZAP70(8) 46774121 831 192 796 434 529 67 31 95 105 4 0.168 1.000 1.000 95 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(66), COL4A2(36), COL4A3(50), COL4A4(122), COL4A5(68), COL4A6(43), F10(8), F11(14), F12(1), F2(13), F2R(8), F5(39), F8(49), F9(15), FGA(41), FGB(10), FGG(10), KLKB1(26), PROC(11), PROS1(17), SERPINC1(7), SERPING1(14) 18897075 668 190 619 185 498 40 19 54 52 5 0.00111 1.000 1.000 96 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 81 ABL1(15), ABL2(12), AKT1(4), AKT2(8), AKT3(3), ARAF(5), BTC(2), CAMK2A(6), CAMK2B(6), CAMK2D(6), CAMK2G(5), CBL(10), CBLB(21), CBLC(16), CDKN1A(3), CDKN1B(1), CRK(3), CRKL(2), EGF(22), EGFR(25), EIF4EBP1(1), ELK1(3), ERBB2(10), ERBB3(5), ERBB4(59), EREG(4), GAB1(8), GRB2(2), GSK3B(3), HBEGF(1), HRAS(3), JUN(1), KRAS(7), MAP2K2(5), MAP2K4(4), MAP2K7(5), MAPK1(4), MAPK10(9), MAPK3(3), MAPK8(2), MAPK9(4), MYC(5), NCK1(2), NCK2(4), NRG1(16), NRG2(9), NRG3(24), NRG4(1), PAK1(4), PAK2(9), PAK3(10), PAK4(8), PAK6(6), PAK7(55), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(3), PIK3R2(6), PIK3R3(2), PIK3R5(17), PLCG1(9), PLCG2(30), PRKCA(9), PRKCG(16), PTK2(7), RAF1(11), RPS6KB1(4), RPS6KB2(2), SHC1(2), SHC2(7), SHC3(15), SHC4(4), SOS1(10), SOS2(13), SRC(2), STAT5A(3), STAT5B(5), TGFA(2) 42394150 706 189 673 353 441 61 29 86 87 2 0.214 1.000 1.000 97 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR1(10), AGTR2(10), ATP8A1(32), AVPR1A(4), AVPR1B(13), BDKRB1(6), BDKRB2(10), BRS3(5), C3AR1(6), CCKAR(12), CCKBR(11), CCR1(10), CCR10(2), CCR2(17), CCR3(11), CCR4(9), CCR5(10), CCR6(4), CCR7(4), CCR8(8), CX3CR1(16), CXCR3(4), CXCR4(3), CXCR6(6), EDNRA(11), EDNRB(7), FPR1(22), FSHR(21), GALR1(5), GALR3(2), GALT(2), GHSR(11), GNB2L1(4), GNRHR(2), GRPR(7), LHCGR(29), MC1R(1), MC2R(5), MC3R(7), MC4R(1), MC5R(8), NMBR(8), NPY1R(29), NPY2R(13), NPY5R(25), NTSR1(8), NTSR2(2), OPRD1(3), OPRK1(23), OPRL1(8), OPRM1(5), OXTR(6), SSTR1(10), SSTR2(7), SSTR3(13), SSTR4(4), TACR1(8), TACR2(9), TACR3(29), TRHR(24), TSHR(8) 22324664 610 189 572 420 422 53 26 58 51 0 0.00126 1.000 1.000 98 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 82 ACVR1(2), ACVR1B(3), ACVRL1(11), AKT1(4), AURKB(2), BMPR1A(2), BMPR2(7), BUB1(6), CDKL1(1), CDKL2(2), CDS1(11), CDS2(5), CLK1(5), CLK2(8), COL4A3BP(3), CSNK2A1(2), CSNK2A2(1), CSNK2B(1), DGKA(3), DGKB(29), DGKD(13), DGKE(8), DGKG(18), DGKH(12), DGKQ(7), DGKZ(9), IMPA1(1), INPP1(3), INPP4A(7), INPP4B(4), INPP5A(5), INPPL1(16), ITPKB(11), MAP3K10(13), MOS(6), NEK1(7), NEK3(2), OCRL(7), PAK4(8), PIK3C2A(8), PIK3C2B(16), PIK3C2G(56), PIK3CA(10), PIK3CB(10), PIK3CG(28), PIM2(5), PLCB1(58), PLCB2(12), PLCB3(4), PLCB4(87), PLCD1(3), PLCG1(9), PLCG2(30), PLK3(3), PRKACA(3), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCA(9), PRKCD(5), PRKCE(7), PRKCG(16), PRKCH(9), PRKCQ(21), PRKCZ(3), PRKD1(9), PRKG1(14), RAF1(11), RPS6KA1(9), RPS6KA2(6), RPS6KA3(2), RPS6KA4(4), RPS6KB1(4), STK11(4), VRK1(1) 47819286 768 187 713 418 523 47 26 76 92 4 0.415 1.000 1.000 99 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 AANAT(1), ACAT2(1), ACMSD(13), ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(6), ALDH3A1(10), ALDH3A2(3), ALDH9A1(3), AOC2(9), AOC3(9), AOX1(29), ASMT(8), CAT(8), CYP19A1(15), CYP1A1(10), CYP1A2(9), CYP2A13(13), CYP2A6(11), CYP2A7(9), CYP2B6(21), CYP2C18(34), CYP2C19(40), CYP2C8(32), CYP2C9(41), CYP2D6(3), CYP2E1(14), CYP2F1(13), CYP2J2(8), CYP3A4(21), CYP3A5(14), CYP3A7(18), CYP4B1(27), CYP51A1(1), DDC(16), ECHS1(3), EHHADH(6), GCDH(6), HAAO(3), HADHA(6), KMO(7), KYNU(16), MAOA(4), MAOB(13), SDS(3), TDO2(4), TPH1(12), WARS(5), WARS2(4) 23386276 598 187 563 341 430 38 20 44 63 3 0.0633 1.000 1.000 100 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 53 AKR1C4(10), AKR1D1(21), ARSD(3), ARSE(5), CARM1(7), CYP11B1(17), CYP11B2(12), CYP19A1(15), HEMK1(4), HSD11B1(14), HSD11B2(2), HSD17B12(4), HSD17B2(13), HSD17B3(5), HSD17B7(1), HSD3B1(15), HSD3B2(14), LCMT1(4), LCMT2(1), METTL2B(5), METTL6(2), PRMT2(2), PRMT3(5), PRMT5(7), PRMT7(4), PRMT8(10), SRD5A1(2), STS(7), SULT1E1(16), SULT2A1(9), SULT2B1(6), UGT1A1(12), UGT1A10(18), UGT1A3(14), UGT1A4(10), UGT1A5(10), UGT1A6(15), UGT1A7(12), UGT1A9(16), UGT2A1(25), UGT2A3(32), UGT2B11(23), UGT2B15(31), UGT2B17(30), UGT2B28(29), UGT2B4(35), UGT2B7(19), WBSCR22(2) 20369587 575 180 517 236 389 54 21 40 69 2 2.51e-07 1.000 1.000 101 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 54 ADH1A(17), ADH1B(30), ADH4(12), ADH5(3), ADH6(14), ADH7(16), ADHFE1(6), AGK(8), AGPAT1(1), AGPAT2(3), AGPAT3(5), AGPAT4(6), AGPAT6(3), AKR1A1(4), AKR1B1(2), ALDH1A3(2), ALDH1B1(11), ALDH2(6), ALDH3A1(10), ALDH3A2(3), ALDH7A1(10), ALDH9A1(3), CEL(13), DAK(4), DGAT1(1), DGAT2(7), DGKA(3), DGKB(29), DGKD(13), DGKE(8), DGKG(18), DGKH(12), DGKI(36), DGKQ(7), DGKZ(9), GK(7), GLA(2), GLB1(10), GPAM(6), LCT(54), LIPA(5), LIPC(10), LIPF(17), LIPG(10), LPL(6), MGLL(9), PNLIP(9), PNLIPRP1(10), PNPLA3(3), PPAP2B(11), PPAP2C(8) 24538582 512 180 469 228 343 47 21 51 48 2 0.000151 1.000 1.000 102 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 92 ACTB(9), BCL2(3), CABIN1(17), CALM1(1), CALM2(1), CAMK2B(6), CAMK4(17), CD3E(2), CD3G(1), CD69(4), CDKN1A(3), CNR1(12), CREBBP(24), CSF2(2), CSNK2A1(2), CSNK2B(1), CTLA4(2), EGR2(5), EGR3(4), EP300(19), FCER1A(17), FCGR3A(9), FOS(2), GATA3(9), GATA4(5), GSK3A(1), GSK3B(3), HRAS(3), ICOS(3), IFNA1(1), IFNB1(6), IFNG(4), IL10(2), IL13(2), IL1B(8), IL2(4), IL2RA(7), IL3(3), IL4(1), IL6(2), ITK(25), KPNA5(2), MAP2K7(5), MAPK14(5), MAPK8(2), MAPK9(4), MEF2A(3), MEF2B(2), MEF2D(6), MYF5(16), NCK2(4), NFAT5(11), NFATC1(17), NFATC2(12), NFATC3(11), NFATC4(18), NFKB2(5), NFKBIB(1), NPPB(6), NUP214(15), OPRD1(3), P2RX7(4), PAK1(4), PIN1(1), PPIA(1), PPP3CB(4), PPP3CC(2), PTPRC(36), RELA(4), RPL13A(2), SFN(2), SLA(3), SP1(5), SP3(1), TGFB1(2), TNF(1), TRAF2(2), TRPV6(30), VAV1(19), VAV2(5), VAV3(11), XPO5(8) 38810128 547 179 525 307 359 39 23 49 72 5 0.626 1.000 1.000 103 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 52 ADORA3(12), ALG6(2), CCKBR(11), CCR2(17), CCR3(11), CCR5(10), CELSR1(31), CELSR2(26), CELSR3(32), CHRM2(26), CHRM3(26), CXCR3(4), DRD4(1), EDNRA(11), EMR2(6), EMR3(22), F2R(8), FSHR(21), GHRHR(6), GNRHR(2), GPR116(38), GPR132(3), GPR133(14), GPR143(4), GPR17(1), GPR18(5), GPR55(6), GPR56(4), GPR61(7), GPR84(9), GRM1(13), GRPR(7), HRH4(6), LGR6(22), LPHN2(49), LPHN3(24), LTB4R2(1), NTSR1(8), OR2M4(14), P2RY11(2), P2RY13(4), PTGFR(21), SMO(10), SSTR2(7), TAAR5(4), TSHR(8), VN1R1(1) 28348932 577 178 547 383 376 50 26 61 62 2 0.185 1.000 1.000 104 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ADCY4(5), ADCY6(9), ADCY8(54), CACNA1A(38), CACNA1B(38), GNAS(33), GNAT3(5), GNB1(1), GNB3(7), GRM4(22), ITPR3(12), KCNB1(37), PDE1A(44), PLCB2(12), PRKACA(3), PRKACB(4), PRKACG(10), PRKX(3), SCNN1A(10), SCNN1B(16), SCNN1G(33), TAS1R1(14), TAS1R2(23), TAS1R3(2), TAS2R1(8), TAS2R10(8), TAS2R13(2), TAS2R14(5), TAS2R16(10), TAS2R3(2), TAS2R38(19), TAS2R39(14), TAS2R4(4), TAS2R40(4), TAS2R41(13), TAS2R42(2), TAS2R43(2), TAS2R46(3), TAS2R5(4), TAS2R50(2), TAS2R60(20), TAS2R7(5), TAS2R8(5), TAS2R9(10), TRPM5(13) 24119177 590 178 551 471 394 43 28 60 62 3 0.866 1.000 1.000 105 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 60 AKT1(4), AKT2(8), AKT3(3), BCL10(3), BLNK(15), BTK(15), CARD11(41), CD19(8), CD22(26), CD72(5), CD79A(4), CD81(3), CHUK(2), CR2(35), FCGR2B(3), FOS(2), GSK3B(3), HRAS(3), IKBKB(4), INPP5D(36), JUN(1), KRAS(7), LILRB3(4), LYN(11), MALT1(8), NFAT5(11), NFATC1(17), NFATC2(12), NFATC3(11), NFATC4(18), NFKB1(6), NFKB2(5), NFKBIA(2), NFKBIB(1), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(3), PIK3R2(6), PIK3R3(2), PIK3R5(17), PLCG2(30), PPP3CA(5), PPP3CB(4), PPP3CC(2), PTPN6(5), RAC2(1), RASGRP3(12), SYK(15), VAV1(19), VAV2(5), VAV3(11) 31376463 530 177 510 248 334 35 27 60 67 7 0.0209 1.000 1.000 106 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 46 IMPA1(1), IMPA2(5), INPP1(3), INPP4A(7), INPP4B(4), INPP5A(5), INPP5B(7), INPPL1(16), IPMK(2), ISYNA1(1), ITPK1(6), ITPKB(11), MINPP1(1), MIOX(5), OCRL(7), PI4KA(22), PI4KB(8), PIK3C3(3), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIP4K2A(6), PIP4K2B(3), PIP4K2C(2), PIP5K1A(6), PIP5K1B(21), PIP5K1C(9), PLCB1(58), PLCB2(12), PLCB3(4), PLCB4(87), PLCD1(3), PLCD3(4), PLCD4(5), PLCE1(56), PLCG1(9), PLCG2(30), PLCZ1(30), SYNJ1(23), SYNJ2(22) 31106789 560 176 526 264 383 30 27 53 64 3 0.00161 1.000 1.000 107 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 66 ACAA1(6), ACADL(5), ACADM(5), ACOX1(8), ACOX2(6), ACOX3(13), ACSL1(8), ACSL3(8), ACSL4(5), ACSL5(22), ACSL6(13), ADIPOQ(5), ANGPTL4(5), APOA1(1), APOA5(5), APOC3(2), AQP7(5), CD36(6), CPT1A(14), CPT1B(9), CPT1C(18), CPT2(2), CYP27A1(4), CYP4A11(29), CYP4A22(23), CYP7A1(8), CYP8B1(13), DBI(1), EHHADH(6), FABP1(6), FABP2(7), FABP3(1), FABP4(2), FABP7(1), FADS2(4), GK(7), HMGCS2(18), ILK(2), LPL(6), ME1(22), MMP1(14), NR1H3(4), OLR1(6), PCK1(25), PCK2(6), PDPK1(5), PLTP(1), PPARA(8), PPARD(3), PPARG(12), RXRA(4), RXRB(4), RXRG(6), SCD(4), SCP2(4), SLC27A1(3), SLC27A2(16), SLC27A4(5), SLC27A5(10), SLC27A6(34), SORBS1(16), UBC(6), UCP1(5) 27471534 532 176 498 299 358 53 20 38 60 3 0.246 1.000 1.000 108 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 79 ABL1(15), ATM(16), BUB1(6), BUB1B(10), BUB3(1), CCNA1(16), CCNB2(2), CCNB3(31), CCND2(7), CCND3(2), CCNE1(4), CCNE2(6), CCNH(1), CDAN1(6), CDC14A(6), CDC14B(3), CDC20(1), CDC25A(8), CDC25B(4), CDC25C(5), CDC6(2), CDC7(3), CDH1(6), CDK2(1), CDKN1A(3), CHEK1(2), CHEK2(2), DTX4(4), E2F1(6), E2F2(5), E2F3(4), E2F4(3), E2F5(3), E2F6(1), EP300(19), ESPL1(19), GSK3B(3), HDAC1(2), HDAC2(2), HDAC3(5), HDAC4(11), HDAC5(6), HDAC6(3), HDAC8(5), MAD1L1(6), MAD2L1(1), MAD2L2(2), MCM2(11), MCM3(9), MCM4(8), MCM5(5), MCM6(5), MCM7(1), MDM2(4), MPEG1(6), MPL(9), PCNA(2), PLK1(4), PRKDC(22), PTPRA(9), PTTG1(1), RB1(10), RBL1(14), SKP2(2), SMAD4(2), TBC1D8(11), TFDP1(2), TGFB1(2), WEE1(2) 45841062 420 174 413 209 254 41 22 59 42 2 0.304 1.000 1.000 109 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 71 AKT1(4), AKT2(8), AKT3(3), BTK(15), CSF2(2), FCER1A(17), FCER1G(1), FYN(8), GAB2(4), GRB2(2), HRAS(3), IL13(2), IL3(3), IL4(1), IL5(4), INPP5D(36), KRAS(7), LAT(3), LCP2(8), LYN(11), MAP2K2(5), MAP2K3(9), MAP2K4(4), MAP2K6(3), MAP2K7(5), MAPK1(4), MAPK10(9), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MAPK3(3), MAPK8(2), MAPK9(4), MS4A2(13), PDK1(2), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(3), PIK3R2(6), PIK3R3(2), PIK3R5(17), PLA2G12B(3), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(19), PLA2G4A(16), PLA2G5(2), PLA2G6(13), PLCG1(9), PLCG2(30), PRKCA(9), PRKCD(5), PRKCE(7), RAC2(1), RAF1(11), SOS1(10), SOS2(13), SYK(15), TNF(1), VAV1(19), VAV2(5), VAV3(11) 30045277 519 174 499 243 323 41 18 61 72 4 0.0144 1.000 1.000 110 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(6), AGT(8), AGTR1(10), AGTR2(10), CMA1(6), COL4A1(66), COL4A2(36), COL4A3(50), COL4A4(122), COL4A5(68), COL4A6(43), REN(12) 10723906 437 172 404 109 339 20 8 25 40 5 0.0512 1.000 1.000 111 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 26 CPEB1(11), EGFR(25), ERBB2(10), ERBB4(59), ETS1(4), ETS2(8), ETV6(10), ETV7(7), FMN2(86), GRB2(2), KRAS(7), MAPK1(4), MAPK3(3), NOTCH1(9), NOTCH2(25), NOTCH3(27), NOTCH4(63), PIWIL1(23), PIWIL2(13), PIWIL3(16), PIWIL4(4), RAF1(11), SOS1(10), SOS2(13), SPIRE1(3), SPIRE2(7) 21390349 460 171 443 216 317 33 14 53 42 1 0.272 1.000 1.000 112 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 79 AIFM1(3), AKT1(4), AKT2(8), AKT3(3), APAF1(6), ATM(16), BAX(4), BCL2(3), BIRC2(6), BIRC3(7), CAPN1(5), CAPN2(6), CASP10(6), CASP3(2), CASP7(4), CASP8(9), CASP9(2), CFLAR(4), CHUK(2), CSF2RB(24), CYCS(1), DFFA(2), DFFB(2), FAS(5), FASLG(15), IKBKB(4), IL1A(5), IL1B(8), IL1R1(12), IL1RAP(3), IL3(3), IL3RA(8), IRAK1(5), IRAK2(15), IRAK3(11), IRAK4(3), MYD88(1), NFKB1(6), NFKB2(5), NFKBIA(2), NTRK1(16), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(3), PIK3R2(6), PIK3R3(2), PIK3R5(17), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKACA(3), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), RELA(4), RIPK1(3), TNF(1), TNFRSF10A(7), TNFRSF10B(5), TNFRSF10C(4), TNFRSF10D(9), TNFRSF1A(4), TNFSF10(9), TRAF2(2) 35079562 429 168 415 248 263 31 19 56 59 1 0.873 1.000 1.000 113 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 70 ACACB(23), ACSL1(8), ACSL3(8), ACSL4(5), ACSL5(22), ACSL6(13), ADIPOQ(5), ADIPOR1(5), ADIPOR2(1), AGRP(1), AKT1(4), AKT2(8), AKT3(3), CAMKK1(3), CAMKK2(9), CD36(6), CHUK(2), CPT1A(14), CPT1B(9), CPT1C(18), CPT2(2), G6PC(5), G6PC2(3), IKBKB(4), IRS1(5), IRS2(3), IRS4(11), JAK1(7), JAK2(8), JAK3(11), LEP(4), LEPR(31), MAPK10(9), MAPK8(2), MAPK9(4), NFKB1(6), NFKB2(5), NFKBIA(2), NFKBIB(1), NPY(4), PCK1(25), PCK2(6), POMC(4), PPARA(8), PPARGC1A(26), PRKAA1(1), PRKAA2(32), PRKAB1(2), PRKAB2(2), PRKAG1(3), PRKAG2(8), PRKAG3(11), PRKCQ(21), PTPN11(10), RELA(4), RXRA(4), RXRB(4), RXRG(6), SLC2A1(5), SLC2A4(8), SOCS3(1), STAT3(11), STK11(4), TNF(1), TNFRSF1A(4), TNFRSF1B(4), TRAF2(2), TYK2(8) 35378840 519 168 501 306 329 49 22 52 67 0 0.726 1.000 1.000 114 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CD2BP2(3), CDC40(7), CLK2(8), CLK3(2), COL2A1(44), CPSF1(8), CPSF2(2), CPSF3(3), CSTF1(6), CSTF2(4), CSTF2T(4), CSTF3(5), DDIT3(3), DDX1(4), DDX20(11), DHX15(5), DHX16(9), DHX38(10), DHX8(11), DHX9(11), DICER1(23), DNAJC8(2), FUS(1), GIPC1(6), LSM7(2), METTL3(3), NCBP1(1), NONO(10), NUDT21(3), NXF1(5), PABPN1(2), PAPOLA(4), PHF5A(2), POLR2A(13), PPM1G(2), PRPF18(4), PRPF3(6), PRPF4(3), PRPF4B(6), PRPF8(15), PSKH1(2), PTBP1(3), PTBP2(8), RBM17(1), RBM5(9), RNGTT(2), RNMT(9), RNPS1(2), SF3A1(6), SF3A2(6), SF3A3(7), SF3B1(17), SF3B2(11), SF3B4(9), SNRPA(2), SNRPA1(2), SNRPB(6), SNRPB2(2), SNRPD1(1), SNRPE(2), SNRPN(6), SNURF(3), SPOP(2), SRPK1(9), SRPK2(2), SRRM1(9), SUPT5H(7), TXNL4A(1), U2AF2(5), XRN2(6) 45295081 430 167 423 181 249 34 29 58 59 1 0.317 1.000 1.000 115 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 33 AKT1(4), AKT2(8), AKT3(3), DAG1(9), DRD2(16), EGFR(25), EPHB2(36), GRB2(2), ITPKB(11), ITPR1(36), ITPR2(20), ITPR3(12), KCNJ3(21), KCNJ5(13), KCNJ9(6), MAPK1(4), PI3(6), PIK3CB(10), PITX2(6), PLCB1(58), PLCB2(12), PLCB3(4), PLCB4(87), RAF1(11), RGS20(2), SHC1(2), SOS1(10), SOS2(13), SRC(2), STAT3(11), TERF2IP(2) 24252675 462 167 427 259 309 41 20 44 44 4 0.205 1.000 1.000 116 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 50 ACTA1(4), AGT(8), AKT1(4), CALM1(1), CALM2(1), CALR(2), CAMK1(5), CAMK1G(12), CAMK4(17), CREBBP(24), CSNK1A1(5), EDN1(9), ELSPBP1(8), F2(13), FGF2(1), GATA4(5), GSK3B(3), HAND1(2), HAND2(5), HRAS(3), IGF1(11), LIF(1), MAPK1(4), MAPK14(5), MAPK3(3), MAPK8(2), MEF2C(3), MYH2(100), NFATC1(17), NFATC2(12), NFATC3(11), NFATC4(18), NKX2-5(1), NPPA(5), PIK3CA(10), PIK3R1(3), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), RAF1(11), RPS6KB1(4), SYT1(23) 21336602 414 166 386 241 275 40 16 37 41 5 0.747 1.000 1.000 117 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(17), ADH1B(30), ADH4(12), ADH6(14), ADH7(16), ADHFE1(6), AGPAT1(1), AGPAT2(3), AGPAT3(5), AGPAT4(6), AKR1A1(4), AKR1B1(2), ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(6), ALDH3A1(10), ALDH3A2(3), ALDH9A1(3), CEL(13), DGAT1(1), DGKA(3), DGKB(29), DGKD(13), DGKE(8), DGKG(18), DGKH(12), DGKQ(7), DGKZ(9), GK(7), GLA(2), GLB1(10), LCT(54), LIPC(10), LIPF(17), LIPG(10), LPL(6), PNLIP(9), PNLIPRP1(10), PPAP2B(11), PPAP2C(8) 20528996 441 165 402 206 308 38 17 40 36 2 0.00142 1.000 1.000 118 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 81 ATF2(6), CHUK(2), DAXX(10), ELK1(3), FOS(2), GRB2(2), HRAS(3), IKBKB(4), JUN(1), MAP2K2(5), MAP2K3(9), MAP2K4(4), MAP2K5(5), MAP2K6(3), MAP2K7(5), MAP3K1(4), MAP3K10(13), MAP3K11(6), MAP3K12(3), MAP3K13(15), MAP3K2(8), MAP3K3(8), MAP3K4(19), MAP3K5(23), MAP3K6(5), MAP3K7(1), MAP3K9(27), MAP4K1(12), MAP4K2(7), MAP4K3(10), MAP4K4(12), MAP4K5(5), MAPK1(4), MAPK10(9), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MAPK3(3), MAPK4(17), MAPK6(8), MAPK7(4), MAPK8(2), MAPK9(4), MAPKAPK2(5), MAPKAPK3(5), MAPKAPK5(1), MEF2A(3), MEF2B(2), MEF2C(3), MEF2D(6), MKNK1(6), MKNK2(4), MYC(5), NFKB1(6), NFKBIA(2), PAK1(4), PAK2(9), RAF1(11), RELA(4), RIPK1(3), RPS6KA1(9), RPS6KA2(6), RPS6KA3(2), RPS6KA4(4), RPS6KA5(7), RPS6KB1(4), RPS6KB2(2), SHC1(2), SP1(5), STAT1(5), TGFB1(2), TGFB2(3), TGFB3(3), TRAF2(2) 39094051 440 164 430 233 258 48 23 59 51 1 0.669 1.000 1.000 119 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(66), COL4A2(36), COL4A3(50), COL4A4(122), COL4A5(68), COL4A6(43), P4HB(3), SLC23A1(6), SLC23A2(4), SLC2A1(5), SLC2A3(7) 10605285 410 164 379 87 318 18 10 24 36 4 0.000227 1.000 1.000 120 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(2), ACSS2(4), ACYP1(1), ADH1A(17), ADH1B(30), ADH4(12), ADH5(3), ADH6(14), ADH7(16), ADHFE1(6), AKR1A1(4), ALDH1A3(2), ALDH1B1(11), ALDH2(6), ALDH3A1(10), ALDH3A2(3), ALDH3B1(3), ALDH3B2(8), ALDH7A1(10), ALDH9A1(3), ALDOA(1), ALDOB(14), ALDOC(4), BPGM(3), DLAT(4), DLD(3), ENO1(4), ENO2(5), ENO3(4), FBP1(3), FBP2(2), G6PC(5), G6PC2(3), GALM(2), GAPDH(2), GAPDHS(3), GCK(16), GPI(3), HK1(3), HK2(15), HK3(15), LDHA(5), LDHAL6A(6), LDHAL6B(6), LDHB(2), LDHC(7), PDHA1(4), PDHA2(20), PDHB(1), PFKL(3), PFKP(2), PGAM2(3), PGAM4(1), PGK1(3), PGK2(36), PGM1(6), PGM3(1), PKLR(14), TPI1(1) 24794019 400 163 366 202 269 27 23 40 41 0 0.00919 1.000 1.000 121 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 AKR1C3(12), ALOX12(6), ALOX12B(15), ALOX15(10), ALOX15B(9), ALOX5(14), CBR3(1), CYP2B6(21), CYP2C18(34), CYP2C19(40), CYP2C8(32), CYP2C9(41), CYP2E1(14), CYP2J2(8), CYP2U1(2), CYP4A11(29), CYP4A22(23), CYP4F2(17), CYP4F3(25), EPHX2(6), GGT1(8), GPX3(2), GPX5(19), GPX6(19), LTA4H(5), PLA2G12B(3), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(19), PLA2G4A(16), PLA2G5(2), PLA2G6(13), PTGDS(3), PTGES2(1), PTGIS(18), PTGS1(20), PTGS2(13), TBXAS1(16) 16489245 555 163 517 332 406 35 10 35 66 3 0.0303 1.000 1.000 122 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 66 AKT1(4), AKT2(8), AKT3(3), CASP9(2), CDC42(2), HRAS(3), KDR(57), KRAS(7), MAP2K2(5), MAPK1(4), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MAPK3(3), MAPKAPK2(5), MAPKAPK3(5), NFAT5(11), NFATC1(17), NFATC2(12), NFATC3(11), NFATC4(18), NOS3(20), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(3), PIK3R2(6), PIK3R3(2), PIK3R5(17), PLA2G12B(3), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(19), PLA2G4A(16), PLA2G5(2), PLA2G6(13), PLCG1(9), PLCG2(30), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKCA(9), PRKCG(16), PTGS2(13), PTK2(7), PXN(2), RAC2(1), RAF1(11), SH2D2A(5), SHC2(7), SPHK1(2), SPHK2(8), SRC(2), VEGFA(4) 30042899 502 163 483 236 323 36 14 62 64 3 0.0183 1.000 1.000 123 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(4), AKT1(4), BDKRB2(10), CALM1(1), CALM2(1), CAV1(1), CHRM1(5), CHRNA1(7), FLT1(42), FLT4(31), KDR(57), NOS3(20), PDE2A(16), PDE3A(30), PDE3B(6), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKG1(14), PRKG2(16), RYR2(99), SLC7A1(6), SYT1(23) 17323211 420 163 396 237 283 36 10 40 49 2 0.229 1.000 1.000 124 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP1(4), ACP2(3), ACP5(3), ACPP(9), ACPT(3), ALPI(9), ALPL(11), ALPP(9), ALPPL2(12), CYP19A1(15), CYP1A1(10), CYP1A2(9), CYP2A13(13), CYP2A6(11), CYP2A7(9), CYP2B6(21), CYP2C18(34), CYP2C19(40), CYP2C8(32), CYP2C9(41), CYP2D6(3), CYP2E1(14), CYP2F1(13), CYP2J2(8), CYP3A4(21), CYP3A5(14), CYP3A7(18), CYP4B1(27), CYP51A1(1), PON1(14) 12424580 431 162 401 253 324 22 11 20 52 2 0.00946 1.000 1.000 125 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 61 AKT1(4), AKT2(8), AKT3(3), CDC42(2), CDK2(1), CDKN1B(1), CREB5(9), ERBB4(59), F2RL2(8), GAB1(8), GRB2(2), GSK3A(1), GSK3B(3), IFI27(2), IGF1(11), IGFBP1(3), INPPL1(16), IRS1(5), IRS2(3), IRS4(11), MET(23), MYC(5), NOLC1(7), PAK1(4), PAK2(9), PAK3(10), PAK4(8), PAK6(6), PAK7(55), PARD3(20), PARD6A(1), PDK1(2), PIK3CA(10), PIK3CD(8), PPP1R13B(9), PREX1(10), PTK2(7), PTPN1(4), RPS6KA1(9), RPS6KA2(6), RPS6KA3(2), RPS6KB1(4), SFN(2), SHC1(2), SLC2A4(8), SOS1(10), SOS2(13), TSC1(9), TSC2(14), YWHAB(1), YWHAE(2), YWHAG(2), YWHAQ(3) 32347743 445 161 426 241 270 44 21 57 52 1 0.663 1.000 1.000 126 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 55 BMP2(7), BMP4(5), BMP5(33), BMP6(12), BMP7(5), BMP8A(2), BMP8B(1), BTRC(4), CSNK1A1(5), CSNK1A1L(7), CSNK1D(3), CSNK1E(5), CSNK1G1(5), CSNK1G2(3), CSNK1G3(3), DHH(2), FBXW11(6), GLI1(17), GLI2(44), GLI3(19), GSK3B(3), HHIP(26), IHH(4), LRP2(108), PRKACA(3), PRKACB(4), PRKACG(10), PRKX(3), PTCH1(6), PTCH2(18), RAB23(1), SHH(3), SMO(10), STK36(17), SUFU(2), WNT1(2), WNT10A(7), WNT10B(6), WNT11(4), WNT16(4), WNT2(8), WNT2B(5), WNT3(5), WNT3A(8), WNT4(1), WNT5A(5), WNT5B(5), WNT6(3), WNT7A(13), WNT7B(6), WNT8A(6), WNT8B(8), WNT9A(4), WNT9B(6), ZIC2(3) 25738464 515 160 479 257 351 47 19 49 49 0 0.0260 1.000 1.000 127 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG1(7), ACTG2(6), ACTR2(3), ACTR3(2), AKT1(4), ANGPTL2(3), CDC42(2), CFL1(2), FLNA(23), FLNC(69), FSCN1(4), FSCN2(2), FSCN3(13), GDI1(2), GDI2(3), LIMK1(5), MYH2(100), MYLK(48), MYLK2(13), PAK1(4), PAK2(9), PAK3(10), PAK4(8), PAK6(6), PAK7(55), RHO(2), ROCK1(6), ROCK2(14), VASP(3), WASF1(5), WASL(4) 20341404 437 160 401 236 302 46 12 39 36 2 0.0256 1.000 1.000 128 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 62 ATM(16), CCNA1(16), CCND1(2), CCND2(7), CCND3(2), CCNE1(4), CCNE2(6), CCNG2(1), CCNH(1), CDC25A(8), CDK2(1), CDK7(2), CDKN1A(3), CDKN1B(1), CDKN2C(1), CREB3L1(7), CREB3L3(10), CREB3L4(7), E2F1(6), E2F2(5), E2F3(4), E2F4(3), E2F5(3), E2F6(1), GBA2(2), MCM2(11), MCM3(9), MCM4(8), MCM5(5), MCM6(5), MCM7(1), MDM2(4), MNAT1(2), MYC(5), MYT1(21), NACA(44), PCNA(2), POLA2(9), POLE(16), POLE2(2), PRIM1(3), RB1(10), RBL1(14), RPA1(3), RPA2(2), TFDP1(2), TFDP2(3), TNXB(126), WEE1(2) 32651895 428 158 419 199 287 36 17 51 35 2 0.0544 1.000 1.000 129 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT1(4), AKT2(8), AKT3(3), BCL2(3), BCR(14), BLNK(15), BTK(15), CD19(8), CD22(26), CD81(3), CR2(35), CSK(1), DAG1(9), FLOT1(1), GRB2(2), GSK3A(1), GSK3B(3), INPP5D(36), ITPR1(36), ITPR2(20), ITPR3(12), LYN(11), MAP4K1(12), MAPK1(4), MAPK3(3), NFATC1(17), NFATC2(12), NR0B2(6), PDK1(2), PIK3CA(10), PIK3CD(8), PIK3R1(3), PLCG2(30), PPP1R13B(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PTPRC(36), RAF1(11), SHC1(2), SOS1(10), SOS2(13), SYK(15), VAV1(19) 31460302 499 158 475 250 319 37 26 52 60 5 0.0543 1.000 1.000 130 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 ASH1L(37), ASH2L(5), CARM1(7), CTCFL(21), DOT1L(12), EED(3), EHMT1(11), EHMT2(9), EZH1(10), EZH2(13), FBXO11(7), HCFC1(21), HSF4(1), JMJD4(7), JMJD6(2), KDM6A(3), MEN1(3), NSD1(21), OGT(9), PAXIP1(3), PPP1CA(3), PPP1CB(5), PPP1CC(2), PRDM2(15), PRDM7(5), PRDM9(51), PRMT5(7), PRMT7(4), PRMT8(10), RBBP5(4), SATB1(22), SETD1A(27), SETD2(16), SETD7(2), SETD8(1), SETDB1(10), SETDB2(4), SETMAR(8), SMYD3(2), STK38(5), SUV39H1(1), SUV39H2(2), SUV420H1(8), SUV420H2(2), SUZ12(3), WHSC1(10), WHSC1L1(6) 50390913 440 157 427 195 278 50 13 60 39 0 0.415 1.000 1.000 131 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA1(6), ACAA2(1), ACADL(5), ACADM(5), ACADS(5), ACADSB(6), ACADVL(1), ACAT2(1), ACOX1(8), ACOX3(13), ACSL1(8), ACSL3(8), ACSL4(5), ACSL5(22), ACSL6(13), ADH1A(17), ADH1B(30), ADH4(12), ADH5(3), ADH6(14), ADH7(16), ADHFE1(6), ALDH1A3(2), ALDH1B1(11), ALDH2(6), ALDH3A1(10), ALDH3A2(3), ALDH7A1(10), ALDH9A1(3), CPT1A(14), CPT1B(9), CPT1C(18), CPT2(2), CYP4A11(29), CYP4A22(23), ECHS1(3), EHHADH(6), GCDH(6), HADH(3), HADHA(6), HADHB(6), HSD17B10(2), HSD17B4(6) 20936387 383 157 352 174 271 26 22 24 39 1 0.00525 1.000 1.000 132 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 40 ALAD(5), ALAS1(2), ALAS2(6), BLVRA(2), BLVRB(1), COX10(7), COX15(4), CP(14), CPOX(4), EARS2(2), EPRS(13), FECH(3), FTH1(3), FTMT(6), GUSB(5), HCCS(2), HMBS(1), HMOX1(1), HMOX2(1), MMAB(2), PPOX(3), UGT1A1(12), UGT1A10(18), UGT1A3(14), UGT1A4(10), UGT1A5(10), UGT1A6(15), UGT1A7(12), UGT1A9(16), UGT2A1(25), UGT2A3(32), UGT2B11(23), UGT2B15(31), UGT2B17(30), UGT2B28(29), UGT2B4(35), UGT2B7(19), UROS(1) 17058931 419 157 375 158 288 33 18 24 54 2 1.08e-05 1.000 1.000 133 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 43 ACTR2(3), ACTR3(2), AKT1(4), AKT2(8), AKT3(3), ANGPTL2(3), ARHGAP1(3), ARHGAP4(4), ARHGEF11(22), BTK(15), CDC42(2), CFL1(2), GDI1(2), GDI2(3), INPPL1(16), ITPR1(36), ITPR2(20), ITPR3(12), LIMK1(5), MYLK(48), MYLK2(13), PAK1(4), PAK2(9), PAK3(10), PAK4(8), PAK6(6), PAK7(55), PDK1(2), PIK3CA(10), PIK3CD(8), PIK3CG(28), PIK3R1(3), PITX2(6), PPP1R13B(9), RACGAP1(4), RHO(2), ROCK1(6), ROCK2(14), SAG(11), WASF1(5), WASL(4) 29440830 430 157 406 214 285 35 17 54 38 1 0.0403 1.000 1.000 134 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ADH1A(17), ADH1B(30), ADH4(12), ADH5(3), ADH6(14), ADH7(16), ADHFE1(6), ALDH1A3(2), ALDH3A1(10), ALDH3B1(3), ALDH3B2(8), AOC2(9), AOC3(9), AOX1(29), CARM1(7), COMT(4), DBH(16), DCT(4), DDC(16), ECH1(5), ESCO1(2), ESCO2(4), FAH(4), GOT1(6), GOT2(6), GSTZ1(1), HEMK1(4), HGD(15), HPD(7), LCMT1(4), LCMT2(1), MAOA(4), MAOB(13), METTL2B(5), METTL6(2), NAT6(5), PNMT(4), PNPLA3(3), PRMT2(2), PRMT3(5), PRMT5(7), PRMT7(4), PRMT8(10), SH3GLB1(2), TAT(21), TH(11), TPO(47), TYR(11), TYRP1(9), WBSCR22(2) 25297475 441 155 414 238 304 36 22 36 43 0 0.230 1.000 1.000 135 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 22 ADRB1(5), AKT1(4), APC(27), CAMP(2), CAV3(2), DAG1(9), DLG4(6), EPHB2(36), GNAI1(2), GNAQ(6), ITPR1(36), ITPR2(20), ITPR3(12), KCNJ3(21), KCNJ5(13), KCNJ9(6), MAPK1(4), PITX2(6), PTX3(1), RHO(2), RYR1(114) 19228527 334 155 322 211 222 31 16 27 36 2 0.429 1.000 1.000 136 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 AICDA(9), CAD(18), CANT1(11), CDA(3), CTPS2(5), DCTD(3), DHODH(5), DPYD(73), DPYS(28), ENTPD1(12), ENTPD3(9), ENTPD4(3), ENTPD5(3), ENTPD6(4), ENTPD8(2), ITPA(1), NME1(1), NME4(1), NME6(3), NME7(5), NT5C1A(6), NT5C1B(24), NT5C2(3), NT5E(6), NT5M(2), NUDT2(2), PNPT1(2), POLA1(3), POLA2(9), POLD1(7), POLD2(2), POLD3(7), POLE(16), POLE2(2), POLR1A(13), POLR1B(8), POLR1C(1), POLR2A(13), POLR2B(14), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(2), POLR2H(2), POLR2J(2), POLR2L(1), POLR3A(8), POLR3B(15), POLR3G(1), POLR3GL(3), POLR3H(1), POLR3K(1), PRIM1(3), PRIM2(6), RRM1(3), RRM2(4), RRM2B(2), TK2(1), TXNRD1(5), TXNRD2(3), TYMS(2), UCK1(3), UCK2(1), UMPS(2), UPB1(11), UPP1(1), UPP2(6), UPRT(1) 34487643 432 154 405 225 279 34 15 61 42 1 0.257 1.000 1.000 137 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 ADAM17(1), APH1A(3), CREBBP(24), CTBP2(1), DLL1(3), DLL3(7), DLL4(12), DTX1(7), DTX2(2), DTX3(4), DTX3L(6), DTX4(4), DVL1(1), DVL2(3), DVL3(9), EP300(19), HDAC1(2), HDAC2(2), HES1(2), JAG1(10), JAG2(10), LFNG(5), MAML1(9), MAML2(7), MAML3(9), MFNG(8), NCOR2(28), NCSTN(5), NOTCH1(9), NOTCH2(25), NOTCH3(27), NOTCH4(63), NUMB(4), NUMBL(4), PSEN1(3), PSEN2(2), PSENEN(1), PTCRA(3), RBPJ(6), RBPJL(4), SNW1(3) 29318409 357 153 353 206 216 39 13 49 40 0 0.903 1.000 1.000 138 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(8), F11(14), F12(1), F13B(35), F2(13), F5(39), F7(7), F8(49), F9(15), FGA(41), FGB(10), FGG(10), LPA(59), PLAT(5), PLG(36), SERPINB2(20), SERPINE1(6), SERPINF2(7), VWF(59) 14972071 434 152 412 173 307 26 23 38 38 2 0.00560 1.000 1.000 139 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 31 AKT1(4), AKT2(8), AKT3(3), BCR(14), BTK(15), CD19(8), DAPP1(6), FLOT1(1), GAB1(8), ITPR1(36), ITPR2(20), ITPR3(12), LYN(11), NR0B2(6), PDK1(2), PHF11(1), PIK3CA(10), PITX2(6), PLCG2(30), PPP1R13B(9), PREX1(10), PTPRC(36), RPS6KA1(9), RPS6KA2(6), RPS6KA3(2), RPS6KB1(4), SAG(11), SYK(15), TEC(13), VAV1(19) 22834294 335 152 314 192 215 25 18 37 38 2 0.314 1.000 1.000 140 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(10), CD28(2), CD3D(7), CSK(1), CTLA4(2), DAG1(9), EPHB2(36), FBXW7(11), GRAP2(6), GRB2(2), ITK(25), ITPKB(11), LAT(3), LCK(15), LCP2(8), MAPK1(4), NCK1(2), NFAT5(11), NFKB1(6), NFKB2(5), NFKBIA(2), NFKBIB(1), NFKBIL1(2), PAK1(4), PAK2(9), PAK3(10), PAK4(8), PAK6(6), PAK7(55), PLCG1(9), PTPRC(36), RAF1(11), RASGRP1(11), RASGRP2(8), RASGRP3(12), RASGRP4(12), SOS1(10), SOS2(13), VAV1(19), ZAP70(8) 23625534 422 152 402 213 266 33 17 48 55 3 0.264 1.000 1.000 141 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 24 AKR1B1(2), GUSB(5), UGDH(1), UGP2(1), UGT1A1(12), UGT1A10(18), UGT1A3(14), UGT1A4(10), UGT1A5(10), UGT1A6(15), UGT1A7(12), UGT1A9(16), UGT2A1(25), UGT2A3(32), UGT2B11(23), UGT2B15(31), UGT2B17(30), UGT2B28(29), UGT2B4(35), UGT2B7(19), XYLB(6) 10705114 346 150 303 136 244 26 14 18 43 1 0.000191 1.000 1.000 142 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 50 ABL1(15), ACTB(9), ACTG1(7), ARHGEF2(21), ARPC5(1), CD14(6), CDC42(2), CDH1(6), CLDN1(5), CTTN(4), EZR(7), FYN(8), HCLS1(15), ITGB1(4), KRT18(4), LY96(4), NCK1(2), NCK2(4), NCL(6), OCLN(6), PRKCA(9), RHOA(2), ROCK1(6), ROCK2(14), TLR4(42), TLR5(22), TUBA1A(4), TUBA1B(4), TUBA1C(2), TUBA3C(24), TUBA3D(13), TUBA3E(4), TUBA4A(7), TUBA8(5), TUBAL3(13), TUBB(1), TUBB1(5), TUBB2A(2), TUBB3(4), TUBB6(10), TUBB8(11), WAS(8), WASL(4), YWHAQ(3) 21660541 355 149 337 171 228 34 10 43 39 1 0.0202 1.000 1.000 143 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 50 ABL1(15), ACTB(9), ACTG1(7), ARHGEF2(21), ARPC5(1), CD14(6), CDC42(2), CDH1(6), CLDN1(5), CTTN(4), EZR(7), FYN(8), HCLS1(15), ITGB1(4), KRT18(4), LY96(4), NCK1(2), NCK2(4), NCL(6), OCLN(6), PRKCA(9), RHOA(2), ROCK1(6), ROCK2(14), TLR4(42), TLR5(22), TUBA1A(4), TUBA1B(4), TUBA1C(2), TUBA3C(24), TUBA3D(13), TUBA3E(4), TUBA4A(7), TUBA8(5), TUBAL3(13), TUBB(1), TUBB1(5), TUBB2A(2), TUBB3(4), TUBB6(10), TUBB8(11), WAS(8), WASL(4), YWHAQ(3) 21660541 355 149 337 171 228 34 10 43 39 1 0.0202 1.000 1.000 144 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AADAT(5), AANAT(1), ACAT2(1), ACMSD(13), AFMID(1), ALDH1A3(2), ALDH1B1(11), ALDH2(6), ALDH3A1(10), ALDH3A2(3), ALDH7A1(10), ALDH9A1(3), AOC2(9), AOC3(9), AOX1(29), ASMT(8), CARM1(7), CAT(8), CYP1A1(10), CYP1A2(9), CYP1B1(4), DDC(16), ECHS1(3), EHHADH(6), GCDH(6), HAAO(3), HADH(3), HADHA(6), HEMK1(4), HSD17B10(2), HSD17B4(6), INMT(13), KMO(7), KYNU(16), LCMT1(4), LCMT2(1), LNX1(19), MAOA(4), MAOB(13), METTL2B(5), METTL6(2), NFX1(10), OGDH(9), OGDHL(44), PRMT2(2), PRMT3(5), PRMT5(7), PRMT7(4), PRMT8(10), TDO2(4), TPH1(12), TPH2(13), WARS(5), WARS2(4), WBSCR22(2) 25767980 429 148 408 221 287 35 19 46 40 2 0.0953 1.000 1.000 145 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 60 APAF1(6), ATM(16), ATR(22), BAI1(16), BAX(4), CASP3(2), CASP8(9), CASP9(2), CCNB2(2), CCNB3(31), CCND1(2), CCND2(7), CCND3(2), CCNE1(4), CCNE2(6), CCNG1(2), CCNG2(1), CDK2(1), CDK6(2), CDKN1A(3), CHEK1(2), CHEK2(2), CYCS(1), DDB2(3), EI24(3), FAS(5), GADD45B(2), GTSE1(8), IGF1(11), IGFBP3(3), MDM2(4), MDM4(2), PERP(3), PPM1D(4), RFWD2(7), RPRM(3), RRM2(4), RRM2B(2), SERPINB5(8), SERPINE1(6), SESN1(1), SESN2(7), SESN3(1), SFN(2), STEAP3(9), THBS1(31), TNFRSF10B(5), TP53I3(2), TP73(6), TSC2(14), ZMAT3(1) 26436248 302 148 295 169 194 24 16 34 33 1 0.735 1.000 1.000 146 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 IMPA1(1), INPP1(3), INPP4A(7), INPP4B(4), INPP5A(5), INPPL1(16), ITPKB(11), MIOX(5), OCRL(7), PIK3C2A(8), PIK3C2B(16), PIK3C2G(56), PIK3CA(10), PIK3CB(10), PIK3CG(28), PLCB1(58), PLCB2(12), PLCB3(4), PLCB4(87), PLCD1(3), PLCG1(9), PLCG2(30) 18985076 390 148 352 175 272 20 16 34 45 3 0.00373 1.000 1.000 147 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 64 ADAM10(9), ADAM17(1), ATP6AP1(3), ATP6V0A1(13), ATP6V0A2(5), ATP6V0A4(23), ATP6V0C(1), ATP6V0D1(1), ATP6V0D2(9), ATP6V0E1(1), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1E2(3), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(7), ATP6V1H(5), CASP3(2), CDC42(2), CHUK(2), CSK(1), EGFR(25), F11R(7), GIT1(6), HBEGF(1), IGSF5(12), IKBKB(4), JAM2(11), JAM3(3), JUN(1), LYN(11), MAP2K4(4), MAPK10(9), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MAPK8(2), MAPK9(4), MET(23), NFKB1(6), NFKB2(5), NFKBIA(2), NOD1(9), PAK1(4), PLCG1(9), PLCG2(30), PTPN11(10), PTPRZ1(27), RELA(4), SRC(2), TCIRG1(6), TJP1(16) 29808581 373 147 366 223 223 31 17 52 49 1 0.884 1.000 1.000 148 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ADH1A(17), ADH1B(30), ADH4(12), ADH6(14), ADH7(16), ADHFE1(6), AKR1A1(4), ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(6), ALDH3A1(10), ALDH3A2(3), ALDH3B1(3), ALDH3B2(8), ALDH9A1(3), ALDOA(1), ALDOB(14), ALDOC(4), BPGM(3), DLAT(4), DLD(3), ENO1(4), ENO2(5), ENO3(4), FBP1(3), FBP2(2), G6PC(5), GAPDH(2), GCK(16), GPI(3), HK1(3), HK2(15), HK3(15), LDHA(5), LDHB(2), LDHC(7), PDHA1(4), PDHA2(20), PDHB(1), PFKP(2), PGK1(3), PGM1(6), PGM3(1), PKLR(14), TPI1(1) 20812840 341 146 311 163 231 26 18 35 31 0 0.00296 1.000 1.000 149 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ADH1A(17), ADH1B(30), ADH4(12), ADH6(14), ADH7(16), ADHFE1(6), AKR1A1(4), ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(6), ALDH3A1(10), ALDH3A2(3), ALDH3B1(3), ALDH3B2(8), ALDH9A1(3), ALDOA(1), ALDOB(14), ALDOC(4), BPGM(3), DLAT(4), DLD(3), ENO1(4), ENO2(5), ENO3(4), FBP1(3), FBP2(2), G6PC(5), GAPDH(2), GCK(16), GPI(3), HK1(3), HK2(15), HK3(15), LDHA(5), LDHB(2), LDHC(7), PDHA1(4), PDHA2(20), PDHB(1), PFKP(2), PGK1(3), PGM1(6), PGM3(1), PKLR(14), TPI1(1) 20812840 341 146 311 163 231 26 18 35 31 0 0.00296 1.000 1.000 150 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 63 ACHE(9), AGPAT1(1), AGPAT2(3), AGPAT3(5), AGPAT4(6), AGPAT6(3), CDS1(11), CDS2(5), CHAT(20), CHKA(2), CHKB(3), CHPT1(1), CRLS1(1), DGKA(3), DGKB(29), DGKD(13), DGKE(8), DGKG(18), DGKH(12), DGKI(36), DGKQ(7), DGKZ(9), ESCO1(2), ESCO2(4), ETNK1(5), GNPAT(1), GPAM(6), GPD1(10), GPD1L(2), GPD2(3), LYPLA1(1), LYPLA2(1), NAT6(5), PCYT1A(3), PCYT1B(9), PEMT(2), PISD(2), PLA2G12B(3), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(19), PLA2G4A(16), PLA2G5(2), PLA2G6(13), PLD1(14), PLD2(8), PNPLA3(3), PPAP2B(11), PPAP2C(8), PTDSS2(3), SH3GLB1(2) 27808795 382 146 360 202 244 32 17 40 46 3 0.267 1.000 1.000 151 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 B2M(5), CALR(2), CANX(1), CD4(9), CD74(8), CD8A(2), CD8B(9), CIITA(18), CTSS(7), HLA-A(4), HLA-B(6), HLA-C(2), HLA-DMA(7), HLA-DMB(7), HLA-DOA(6), HLA-DOB(9), HLA-DPA1(2), HLA-DPB1(2), HLA-DQA1(7), HLA-DQA2(8), HLA-DQB1(4), HLA-DRA(13), HLA-DRB1(5), HLA-DRB5(1), HLA-E(1), HLA-F(2), HLA-G(5), HSP90AA1(2), HSP90AB1(8), HSPA5(7), IFI30(1), IFNA1(1), IFNA10(2), IFNA13(1), IFNA14(8), IFNA16(11), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA5(4), IFNA6(3), IFNA7(6), IFNA8(3), KIR2DL3(5), KIR3DL1(14), KIR3DL2(16), KIR3DL3(5), KLRC1(4), KLRC2(1), KLRC3(12), KLRC4(6), KLRD1(7), LGMN(5), LTA(5), NFYA(1), NFYB(2), NFYC(2), PDIA3(3), PSME2(4), RFX5(5), RFXANK(1), RFXAP(1), TAP1(2), TAP2(7), TAPBP(1) 19638215 329 146 314 203 217 30 14 35 32 1 0.617 1.000 1.000 152 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM1(1), CALM2(1), DLG4(6), GRIN1(8), GRIN2A(107), GRIN2B(59), GRIN2C(10), GRIN2D(11), NOS1(77), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCA(9), SYT1(23) 10852964 350 146 327 218 255 29 8 23 33 2 0.265 1.000 1.000 153 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 58 ALG2(5), BAK1(2), BAX(4), BFAR(1), BTK(15), CAD(18), CASP10(6), CASP3(2), CASP8(9), CD7(2), CDK2AP1(2), CSNK1A1(5), DAXX(10), DEDD(2), DEDD2(3), DFFA(2), DIABLO(2), EGFR(25), EPHB2(36), FAF1(9), FAIM2(6), HSPB1(2), IL1A(5), MAP2K4(4), MAP2K7(5), MAP3K1(4), MAP3K5(23), MAPK1(4), MAPK10(9), MAPK8(2), MAPK8IP1(7), MAPK8IP2(8), MAPK8IP3(9), MAPK9(4), MET(23), NFAT5(11), NFKB1(6), NFKB2(5), NFKBIA(2), NFKBIB(1), NFKBIL1(2), NR0B2(6), PTPN13(17), RALBP1(3), RIPK1(3), ROCK1(6), SMPD1(2), TNFRSF6B(4), TPX2(11), TRAF2(2), TUFM(1) 30548804 357 146 345 217 216 24 18 48 50 1 0.968 1.000 1.000 154 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 AGMAT(4), ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(6), ALDH3A1(10), ALDH3A2(3), ALDH4A1(6), ALDH9A1(3), AOC2(9), AOC3(9), ARG1(2), ARG2(2), ASL(7), CKM(3), CKMT1A(1), CKMT2(5), CPS1(29), DAO(12), GAMT(4), GATM(6), GLUD1(2), GOT1(6), GOT2(6), MAOA(4), MAOB(13), NOS1(77), NOS3(20), OAT(4), ODC1(3), OTC(4), P4HA1(10), P4HA2(5), P4HA3(14), P4HB(3), PYCR1(1), RARS(7), SMS(5) 18768312 341 144 323 187 215 35 17 30 43 1 0.183 1.000 1.000 155 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(9), AGPAT1(1), AGPAT2(3), AGPAT3(5), AGPAT4(6), AGPS(5), CDS1(11), CDS2(5), CHAT(20), CHKA(2), CHKB(3), CLC(5), CPT1B(9), DGKA(3), DGKB(29), DGKD(13), DGKE(8), DGKG(18), DGKH(12), DGKQ(7), DGKZ(9), ETNK1(5), GNPAT(1), GPD1(10), GPD2(3), LGALS13(4), LYPLA1(1), LYPLA2(1), PAFAH1B1(6), PAFAH2(2), PCYT1A(3), PCYT1B(9), PEMT(2), PISD(2), PLA2G1B(1), PLA2G2A(2), PLA2G2E(5), PLA2G3(19), PLA2G4A(16), PLA2G5(2), PLA2G6(13), PLCB2(12), PLCG1(9), PLCG2(30), PPAP2B(11), PPAP2C(8) 21257308 360 143 344 184 236 28 12 36 44 4 0.0288 1.000 1.000 156 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(55), C5(23), C6(72), C7(49), ICAM1(2), IL1A(5), IL6(2), ITGA4(45), ITGAL(27), ITGB1(4), ITGB2(17), SELP(38), SELPLG(11), TNF(1), VCAM1(17) 10497617 368 143 333 152 262 11 17 35 38 5 0.000427 1.000 1.000 157 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ADH1A(17), ADH1B(30), ADH4(12), ADH6(14), ADH7(16), ADHFE1(6), ALDH1A3(2), ALDH3A1(10), ALDH3B1(3), ALDH3B2(8), AOC2(9), AOC3(9), AOX1(29), COMT(4), DBH(16), DCT(4), DDC(16), FAH(4), GOT1(6), GOT2(6), GSTZ1(1), HGD(15), HPD(7), MAOA(4), MAOB(13), PNMT(4), TAT(21), TH(11), TPO(47), TYR(11) 13462769 355 143 330 194 256 28 15 22 34 0 0.0534 1.000 1.000 158 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1C4(10), AKR1D1(21), ARSB(3), ARSD(3), ARSE(5), CYP11B1(17), CYP11B2(12), HSD11B1(14), HSD11B2(2), HSD17B2(13), HSD17B3(5), HSD3B1(15), HSD3B2(14), SRD5A1(2), STS(7), SULT1E1(16), SULT2A1(9), UGT1A1(12), UGT1A10(18), UGT1A3(14), UGT1A4(10), UGT1A5(10), UGT1A6(15), UGT1A7(12), UGT1A9(16), UGT2B15(31), UGT2B4(35) 11606136 341 141 307 147 228 36 15 22 38 2 0.000143 1.000 1.000 159 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(2), AKR1B10(10), B4GALT1(2), B4GALT2(2), G6PC(5), G6PC2(3), GAA(8), GALK1(2), GALK2(2), GALT(2), GANC(6), GCK(16), GLA(2), GLB1(10), HK1(3), HK2(15), HK3(15), HSD3B7(5), LALBA(8), LCT(54), MGAM(169), PFKL(3), PFKP(2), PGM1(6), PGM3(1), RDH11(2), RDH12(2), RDH13(3), RDH14(1), UGP2(1) 16418433 362 141 339 214 268 29 6 33 25 1 0.194 1.000 1.000 160 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(10), ALOX15(10), ALOX5(14), CYP1A2(9), CYP2C18(34), CYP2C19(40), CYP2C8(32), CYP2C9(41), CYP2E1(14), CYP2J2(8), CYP3A4(21), CYP3A43(19), CYP3A5(14), CYP3A7(18), HSD3B7(5), PLA2G12B(3), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(19), PLA2G4A(16), PLA2G5(2), PLA2G6(13), RDH11(2), RDH12(2), RDH13(3), RDH14(1) 10175182 369 141 345 206 271 19 11 19 46 3 0.0290 1.000 1.000 161 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 CAD(18), CANT1(11), CDA(3), CTPS2(5), DCTD(3), DHODH(5), DPYD(73), DPYS(28), ENTPD1(12), ITPA(1), NME1(1), NT5E(6), NT5M(2), NUDT2(2), POLB(1), POLD1(7), POLD2(2), POLE(16), POLG(8), POLL(10), POLQ(26), POLR1B(8), POLR2A(13), POLR2B(14), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(2), POLR2H(2), POLR2J(2), POLR2L(1), POLRMT(4), RRM1(3), RRM2(4), TK2(1), TXNRD1(5), TYMS(2), UCK1(3), UCK2(1), UMPS(2), UNG(5), UPB1(11), UPP1(1) 24451868 327 141 302 152 207 29 11 48 31 1 0.0374 1.000 1.000 162 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 35 CALM1(1), CALM2(1), CAMK1(5), CAMK1G(12), ELK1(3), FPR1(22), GNA15(7), GNB1(1), HRAS(3), MAP2K2(5), MAP2K3(9), MAP2K6(3), MAP3K1(4), MAPK1(4), MAPK14(5), MAPK3(3), NCF1(3), NCF2(8), NFATC1(17), NFATC2(12), NFATC3(11), NFATC4(18), NFKB1(6), NFKBIA(2), PAK1(4), PIK3C2G(56), PLCB1(58), PPP3CA(5), PPP3CB(4), PPP3CC(2), RAF1(11), RELA(4), SYT1(23) 15711661 332 140 303 143 226 26 12 29 38 1 0.0183 1.000 1.000 163 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(56), B3GALT4(2), CDR1(13), DGKI(36), IL6ST(11), MRPL19(1), PIGK(7), RPL10(4), RPL11(4), RPL12(1), RPL13(1), RPL13A(2), RPL14(1), RPL15(2), RPL17(2), RPL18(3), RPL18A(2), RPL19(1), RPL21(2), RPL22(2), RPL26(1), RPL27(3), RPL27A(1), RPL29(1), RPL3(2), RPL30(1), RPL32(1), RPL35(1), RPL35A(1), RPL38(1), RPL39(1), RPL3L(5), RPL4(4), RPL5(8), RPL6(1), RPL7(2), RPLP0(1), RPLP2(1), RPS11(1), RPS13(1), RPS15(1), RPS16(1), RPS18(2), RPS19(1), RPS2(2), RPS20(2), RPS23(1), RPS24(1), RPS26(1), RPS27(2), RPS29(1), RPS3A(1), RPS5(1), RPS6(1), RPS6KA1(9), RPS6KA2(6), RPS6KA3(2), RPS6KA6(21), RPS6KB1(4), RPS6KB2(2), RPS7(4), RPS8(1), RPSA(1), SLC36A2(12), TBC1D10C(6), TSPAN9(4), UBB(1), UBC(6) 22127343 288 140 273 168 180 26 14 33 35 0 0.689 1.000 1.000 164 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 38 AKT1(4), AKT2(8), AKT3(3), BCR(14), BLNK(15), BTK(15), CD19(8), CSK(1), DAG1(9), EPHB2(36), GRB2(2), ITPKB(11), LYN(11), MAP2K2(5), MAPK1(4), NFAT5(11), NFKB1(6), NFKB2(5), NFKBIA(2), NFKBIB(1), NFKBIL1(2), PI3(6), PIK3CA(10), PIK3CD(8), PIK3R1(3), PLCG2(30), PPP1R13B(9), RAF1(11), SERPINA4(22), SHC1(2), SOS1(10), SOS2(13), SYK(15), VAV1(19) 22173972 331 140 319 190 202 27 14 43 42 3 0.747 1.000 1.000 165 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(2), B4GALT1(2), B4GALT2(2), FBP2(2), G6PC(5), GAA(8), GALK1(2), GALK2(2), GALT(2), GANAB(6), GCK(16), GLA(2), GLB1(10), HK1(3), HK2(15), HK3(15), LALBA(8), LCT(54), MGAM(169), PFKP(2), PGM1(6), PGM3(1) 13840899 334 139 311 193 248 29 5 29 22 1 0.149 1.000 1.000 166 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 56 APC(27), AXIN1(10), CCND1(2), CCND2(7), CCND3(2), CSNK1E(5), DVL1(1), DVL2(3), DVL3(9), FBXW2(2), FZD1(5), FZD10(4), FZD2(7), FZD3(1), FZD5(2), FZD6(2), FZD7(5), FZD8(6), FZD9(1), GSK3B(3), JUN(1), LDLR(17), MAPK10(9), MAPK9(4), MYC(5), PAFAH1B1(6), PPP2R5C(4), PPP2R5E(5), PRKCA(9), PRKCD(5), PRKCE(7), PRKCG(16), PRKCH(9), PRKCI(8), PRKCQ(21), PRKCZ(3), PRKD1(9), RHOA(2), SFRP4(6), TCF7(1), WNT1(2), WNT10A(7), WNT10B(6), WNT11(4), WNT16(4), WNT2(8), WNT2B(5), WNT3(5), WNT4(1), WNT5A(5), WNT5B(5), WNT6(3), WNT7A(13), WNT7B(6) 24593056 325 139 316 200 205 31 6 35 48 0 0.734 1.000 1.000 167 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 24 ATM(16), BMPR1B(4), CCND2(7), CDKN1B(1), DAZL(5), DMC1(11), EGR1(4), ESR2(10), FSHR(21), GJA4(4), INHA(4), LHCGR(29), MLH1(7), MSH5(13), NCOR1(23), NR5A1(10), NRIP1(10), PGR(16), PRLR(37), PTGER2(7), SMPD1(2), VDR(3), ZP2(17) 14596097 261 138 238 137 172 18 8 29 33 1 0.641 1.000 1.000 168 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 37 AKT1(4), ATF2(6), CDC42(2), DLD(3), DUSP10(9), DUSP4(3), DUSP8(3), GAB1(8), GCK(16), IL1R1(12), JUN(1), MAP2K4(4), MAP2K5(5), MAP2K7(5), MAP3K1(4), MAP3K10(13), MAP3K11(6), MAP3K12(3), MAP3K13(15), MAP3K2(8), MAP3K3(8), MAP3K4(19), MAP3K5(23), MAP3K7(1), MAP3K9(27), MAPK10(9), MAPK7(4), MAPK8(2), MAPK9(4), MYEF2(4), NFATC3(11), NR2C2(1), PAPPA(59), SHC1(2), TRAF6(4), ZAK(7) 21081080 315 138 302 160 211 26 8 35 33 2 0.711 1.000 1.000 169 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(11), ACADL(5), ACADM(5), ACADSB(6), ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(6), ALDH3A1(10), ALDH3A2(3), ALDH9A1(3), AOC2(9), AOC3(9), CNDP1(10), DPYD(73), DPYS(28), ECHS1(3), EHHADH(6), GAD1(14), GAD2(9), HADHA(6), MLYCD(2), SDS(3), SMS(5), UPB1(11) 12394672 273 137 248 118 176 22 10 36 29 0 0.00993 1.000 1.000 170 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 50 ACOX1(8), APOA1(1), CD36(6), CPT1B(9), CREBBP(24), DUSP1(1), EHHADH(6), EP300(19), FABP1(6), HSD17B4(6), HSPA1A(1), JUN(1), LPL(6), MAPK1(4), MAPK3(3), ME1(22), MRPL11(1), MYC(5), NCOA1(9), NCOR1(23), NCOR2(28), NFKBIA(2), NR0B2(6), NR1H3(4), NR2F1(8), NRIP1(10), PDGFA(1), PIK3CA(10), PIK3R1(3), PPARA(8), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCA(9), PTGS2(13), RB1(10), RELA(4), RXRA(4), SP1(5), STAT5A(3), STAT5B(5), TNF(1) 27018423 322 137 312 164 204 30 22 32 30 4 0.503 1.000 1.000 171 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 33 AKT1(4), APC(27), AR(10), CAMP(2), CCL15(3), CCL16(2), DAG1(9), EGFR(25), GNA11(9), GNA15(7), GNAI1(2), GNAQ(6), ITPKB(11), ITPR1(36), ITPR2(20), ITPR3(12), KCNJ3(21), KCNJ5(13), KCNJ9(6), MAPK1(4), MAPK10(9), MAPK14(5), PHKA2(9), PIK3CA(10), PIK3CD(8), PIK3R1(3), PITX2(6), PTX3(1), RAF1(11), SRC(2) 21993923 293 137 282 176 183 24 16 35 34 1 0.730 1.000 1.000 172 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 12 C1QA(6), C1QB(7), C1R(16), C1S(20), C2(35), C3(55), C5(23), C6(72), C7(49), C8B(47), C9(22), MASP1(10) 8278889 362 135 327 156 270 17 12 32 27 4 0.00323 1.000 1.000 173 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 42 AKT1(4), AKT2(8), AKT3(3), CAB39(1), EIF4B(6), EIF4EBP1(1), FIGF(5), HIF1A(4), IGF1(11), MAPK1(4), MAPK3(3), PDPK1(5), PGF(1), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(3), PIK3R2(6), PIK3R3(2), PIK3R5(17), PRKAA1(1), PRKAA2(32), RHEB(2), RICTOR(13), RPS6(1), RPS6KA1(9), RPS6KA2(6), RPS6KA3(2), RPS6KA6(21), RPS6KB1(4), RPS6KB2(2), STK11(4), TSC1(9), TSC2(14), ULK1(11), ULK2(7), ULK3(1), VEGFA(4), VEGFB(2) 21478262 285 135 270 149 172 25 14 37 35 2 0.510 1.000 1.000 174 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOA(1), ALDOB(14), ALDOC(4), DLAT(4), DLD(3), ENO1(4), ENO2(5), ENO3(4), FBP1(3), FBP2(2), G6PC(5), GAPDH(2), GAPDHS(3), GCK(16), GOT1(6), GOT2(6), GPI(3), HK1(3), HK2(15), HK3(15), LDHA(5), LDHAL6B(6), LDHB(2), LDHC(7), MDH1(3), MDH2(4), PC(14), PCK1(25), PDHA1(4), PDHA2(20), PDHB(1), PDHX(2), PFKL(3), PFKP(2), PGAM2(3), PGK1(3), PGK2(36), PKLR(14), TNFAIP1(2), TPI1(1) 18119057 275 133 260 158 192 20 14 23 26 0 0.0998 1.000 1.000 175 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(9), AADAC(16), ABAT(11), ACADS(5), ACAT2(1), ACSM1(29), AKR1B10(10), ALDH1A3(2), ALDH1B1(11), ALDH2(6), ALDH3A1(10), ALDH3A2(3), ALDH5A1(10), ALDH7A1(10), ALDH9A1(3), BDH1(5), DDHD1(8), ECHS1(3), EHHADH(6), GAD1(14), GAD2(9), HADH(3), HADHA(6), HMGCL(4), HMGCS1(2), HMGCS2(18), HSD17B10(2), HSD17B4(6), HSD3B7(5), ILVBL(5), L2HGDH(4), OXCT1(4), OXCT2(5), PDHA1(4), PDHA2(20), PDHB(1), PLA1A(10), PPME1(1), PRDX6(4), RDH11(2), RDH12(2), RDH13(3), RDH14(1) 17313381 293 133 283 150 197 25 18 22 31 0 0.132 1.000 1.000 176 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 41 AKT1(4), ATF1(5), CAMP(2), CREB5(9), CREBBP(24), CRKL(2), DAG1(9), EGR1(4), EGR2(5), EGR3(4), EGR4(5), ELK1(3), FRS2(7), GNAQ(6), JUN(1), MAP1B(27), MAP2K4(4), MAP2K7(5), MAPK1(4), MAPK10(9), MAPK3(3), MAPK8(2), MAPK8IP1(7), MAPK8IP2(8), MAPK8IP3(9), MAPK9(4), NTRK1(16), OPN1LW(8), PIK3C2G(56), PIK3CA(10), PIK3CD(8), PIK3R1(3), PTPN11(10), RPS6KA3(2), SHC1(2), SRC(2), TERF2IP(2), TH(11) 21156942 302 133 285 166 201 24 13 34 29 1 0.631 1.000 1.000 177 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(66), GABBR1(9), GPRC5A(4), GPRC5B(5), GPRC5C(10), GPRC5D(2), GRM1(13), GRM2(16), GRM3(62), GRM4(22), GRM5(17), GRM7(41), GRM8(47) 8913247 314 132 291 230 230 23 12 23 25 1 0.322 1.000 1.000 178 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(11), ACADM(5), ALDH1A3(2), ALDH1B1(11), ALDH2(6), ALDH3A1(10), ALDH3A2(3), ALDH7A1(10), ALDH9A1(3), AOC2(9), AOC3(9), CNDP1(10), DPYD(73), DPYS(28), ECHS1(3), EHHADH(6), GAD1(14), GAD2(9), HADHA(6), HIBCH(1), MLYCD(2), SMS(5), SRM(1), UPB1(11) 11529012 248 132 225 113 157 21 11 32 27 0 0.0345 1.000 1.000 179 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 13 C1QA(6), C1QB(7), C1R(16), C1S(20), C2(35), C3(55), C5(23), C6(72), C7(49), C9(22), MASP1(10), MASP2(11), MBL2(14) 8493602 340 131 310 144 256 14 9 29 28 4 0.00246 1.000 1.000 180 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 36 BTK(15), CALM1(1), CALM2(1), ELK1(3), FCER1A(17), FCER1G(1), FOS(2), GRB2(2), HRAS(3), JUN(1), LYN(11), MAP2K4(4), MAP2K7(5), MAP3K1(4), MAPK1(4), MAPK3(3), MAPK8(2), NFATC1(17), NFATC2(12), NFATC3(11), NFATC4(18), PAK2(9), PIK3CA(10), PIK3R1(3), PLA2G4A(16), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), RAF1(11), SHC1(2), SOS1(10), SYK(15), SYT1(23), VAV1(19) 17975399 275 131 264 134 169 19 13 37 34 3 0.571 1.000 1.000 181 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA1(6), ACAA2(1), ACAD8(3), ACAD9(2), ADH1A(17), ADH1B(30), ADH4(12), ADH5(3), ADH6(14), ADH7(16), ADHFE1(6), AKR1B10(10), AKR1C4(10), AKR1D1(21), ALDH1A3(2), ALDH1B1(11), ALDH2(6), ALDH3A1(10), ALDH3A2(3), ALDH7A1(10), ALDH9A1(3), BAAT(14), CEL(13), CYP27A1(4), CYP7A1(8), HADHB(6), HSD3B7(5), LIPA(5), RDH11(2), RDH12(2), RDH13(3), RDH14(1), SLC27A5(10), SOAT1(3), SOAT2(6), SRD5A1(2) 13517370 280 131 249 128 182 29 22 21 25 1 0.00507 1.000 1.000 182 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(23), ACACB(23), ACAT2(1), ACOT12(15), ACSS1(2), ACSS2(4), ACYP1(1), AKR1B1(2), ALDH1A3(2), ALDH1B1(11), ALDH2(6), ALDH3A1(10), ALDH3A2(3), ALDH7A1(10), ALDH9A1(3), DLAT(4), DLD(3), GLO1(1), GRHPR(1), HAGH(3), LDHA(5), LDHAL6A(6), LDHAL6B(6), LDHB(2), LDHC(7), LDHD(1), MDH1(3), MDH2(4), ME1(22), ME2(2), ME3(8), PC(14), PCK1(25), PCK2(6), PDHA1(4), PDHA2(20), PDHB(1), PKLR(14) 19964758 278 131 268 158 180 17 19 31 30 1 0.504 1.000 1.000 183 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 A4GALT(7), B3GALNT1(6), B3GALT1(15), B3GALT2(1), B3GALT4(2), B3GALT5(1), B3GNT1(3), B3GNT2(2), B3GNT3(7), B3GNT4(4), B3GNT5(2), B4GALNT1(5), B4GALT1(2), B4GALT2(2), B4GALT3(3), B4GALT4(3), B4GALT6(2), FUT1(4), FUT2(4), FUT3(8), FUT4(3), FUT5(8), FUT6(4), FUT7(2), FUT9(29), GBGT1(3), GCNT2(1), PIGA(2), PIGB(3), PIGC(3), PIGF(2), PIGG(9), PIGH(2), PIGK(7), PIGL(3), PIGM(2), PIGN(3), PIGO(15), PIGQ(9), PIGS(1), PIGT(1), PIGU(7), PIGV(9), PIGX(2), PIGZ(4), ST3GAL1(8), ST3GAL2(1), ST3GAL3(2), ST3GAL4(1), ST3GAL5(3), ST3GAL6(4), ST6GALNAC3(7), ST6GALNAC4(4), ST6GALNAC5(10), ST6GALNAC6(2), ST8SIA1(1), ST8SIA5(12), UGCG(1) 20619833 273 131 265 153 153 30 14 45 30 1 0.344 1.000 1.000 184 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 B3GNT6(2), B4GALT5(3), C1GALT1(7), C1GALT1C1(3), GALNT1(4), GALNT10(7), GALNT11(3), GALNT12(8), GALNT13(31), GALNT14(30), GALNT2(7), GALNT3(4), GALNT4(5), GALNT5(13), GALNT6(16), GALNT7(4), GALNT8(28), GALNT9(7), GALNTL5(17), GCNT1(6), GCNT3(8), GCNT4(3), OGT(9), ST3GAL1(8), ST3GAL2(1), ST6GALNAC1(8), WBSCR17(46) 13764968 288 130 271 135 198 14 7 32 37 0 0.0973 1.000 1.000 185 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 65 APAF1(6), BAK1(2), BAX(4), BCL2(3), BCL2L11(8), BIRC2(6), BIRC3(7), BIRC5(3), BNIP3L(1), CASP1(4), CASP10(6), CASP2(1), CASP3(2), CASP4(2), CASP7(4), CASP8(9), CASP9(2), CHUK(2), CYCS(1), DFFA(2), DFFB(2), FAS(5), FASLG(15), GZMB(3), HELLS(6), IKBKB(4), IRF1(2), IRF2(6), IRF3(3), IRF4(2), IRF5(5), IRF6(14), IRF7(5), JUN(1), LTA(5), MAP2K4(4), MAP3K1(4), MAPK10(9), MDM2(4), MYC(5), NFKB1(6), NFKBIA(2), NFKBIB(1), PLEKHG5(12), PRF1(14), RELA(4), RIPK1(3), TNF(1), TNFRSF10B(5), TNFRSF1A(4), TNFRSF1B(4), TNFRSF21(14), TNFRSF25(6), TNFSF10(9), TP73(6), TRAF1(6), TRAF2(2), TRAF3(5) 24040874 283 128 278 163 179 29 14 29 31 1 0.748 1.000 1.000 186 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(27), ATP4A(17), ATP4B(1), ATP5A1(2), ATP5B(1), ATP5C1(3), ATP5F1(7), ATP5G2(2), ATP5H(2), ATP5J(2), ATP5O(5), ATP6AP1(3), ATP6V0A1(13), ATP6V0A2(5), ATP6V0A4(23), ATP6V0C(1), ATP6V0D1(1), ATP6V0D2(9), ATP6V0E1(1), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1E2(3), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(7), ATP6V1H(5), COX10(7), COX15(4), COX4I2(4), COX5B(1), COX6A1(1), COX6B1(2), COX6C(1), COX7B(1), COX7B2(3), COX8A(1), COX8C(2), CYC1(4), LHPP(1), NDUFA10(4), NDUFA12(1), NDUFA13(2), NDUFA4(1), NDUFA9(2), NDUFAB1(1), NDUFB2(3), NDUFB3(1), NDUFB5(3), NDUFB6(2), NDUFB7(2), NDUFC2(2), NDUFS1(2), NDUFS2(3), NDUFS3(4), NDUFS4(3), NDUFS5(1), NDUFS6(2), NDUFS7(3), NDUFS8(3), NDUFV1(1), NDUFV2(1), PPA1(1), PPA2(4), SDHA(4), SDHC(3), SDHD(1), TCIRG1(6), UQCRC1(4), UQCRC2(3), UQCRFS1(3) 23869939 268 128 261 143 153 23 16 43 30 3 0.427 1.000 1.000 187 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 36 AGT(8), AGTR2(10), CALM1(1), CALM2(1), CAMK2A(6), CAMK2B(6), CAMK2D(6), CAMK2G(5), CDK5(6), F2(13), FYN(8), GNA11(9), GNAI1(2), GNB1(1), GRB2(2), HRAS(3), JAK2(8), MAP2K2(5), MAPK1(4), MAPK14(5), MAPK3(3), MAPK8(2), MAPT(10), MYLK(48), PLCG1(9), PRKCA(9), PTK2B(12), RAF1(11), SHC1(2), SOS1(10), STAT1(5), STAT3(11), STAT5A(3), SYT1(23) 17336401 267 127 253 162 164 22 13 34 32 2 0.803 1.000 1.000 188 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 10 C1QA(6), C1QB(7), C1R(16), C1S(20), C2(35), C3(55), C5(23), C6(72), C7(49), C9(22) 6873265 305 127 277 129 229 13 8 28 23 4 0.00572 1.000 1.000 189 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(39), AR(10), ESR1(6), ESR2(10), ESRRA(3), HNF4A(23), NPM1(4), NR0B1(3), NR1D1(1), NR1D2(11), NR1H2(5), NR1H3(4), NR1I2(5), NR1I3(6), NR2C2(1), NR2E1(5), NR2F1(8), NR2F2(2), NR2F6(1), NR3C1(7), NR4A1(4), NR4A2(4), NR5A1(10), NR5A2(23), PGR(16), PPARA(8), PPARD(3), PPARG(12), RARA(4), RARB(9), RARG(3), ROR1(15), RORA(2), RORC(15), RXRA(4), RXRB(4), RXRG(6), THRA(2), THRB(18), VDR(3) 17788226 319 127 304 166 222 26 10 25 36 0 0.0936 1.000 1.000 190 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 31 ACTR2(3), ACTR3(2), AKT1(4), ANGPTL2(3), DAG1(9), DGKA(3), ETFA(3), GCA(3), ITGA9(15), ITPKB(11), ITPR1(36), ITPR2(20), ITPR3(12), MAPK1(4), MAPK3(3), NR1I3(6), PAK1(4), PDE3A(30), PDE3B(6), PI3(6), PIK3C2G(56), PIK3CA(10), PIK3CD(8), PIK3R1(3), RIPK3(10), VASP(3) 20315694 273 127 255 129 186 22 12 24 28 1 0.0190 1.000 1.000 191 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 29 AKT1(4), AKT2(8), AKT3(3), ANKRD6(3), APC(27), AXIN1(10), AXIN2(5), CER1(18), CSNK1A1(5), DACT1(13), DKK1(3), DKK2(19), DKK3(4), DKK4(4), DVL1(1), FSTL1(3), GSK3A(1), GSK3B(3), LRP1(47), MVP(10), NKD1(9), NKD2(7), PIN1(1), PSEN1(3), PTPRA(9), SENP2(9), SFRP1(3), TSHB(7), WIF1(7) 16368436 246 127 237 139 151 29 7 27 31 1 0.662 1.000 1.000 192 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(9), ALPL(11), ALPP(9), ALPPL2(12), ASCC3(16), ATP13A2(13), DDX18(5), DDX19A(1), DDX23(7), DDX4(13), DDX41(8), DDX47(1), DDX50(5), DDX51(5), DDX52(4), DDX54(3), DDX55(2), DDX56(3), DHFR(1), DHX58(3), ENTPD7(2), EP400(28), ERCC2(3), ERCC3(6), FPGS(3), GGH(4), IFIH1(10), MOV10L1(24), NUDT5(1), NUDT8(2), QDPR(3), RAD54B(8), RUVBL2(5), SETX(19), SKIV2L2(6), SMARCA2(14), SMARCA5(5), SPR(4) 26610983 278 126 268 158 177 18 17 27 38 1 0.736 1.000 1.000 193 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(12), ALOX12(6), ALOX15(10), ALOX5(14), CBR3(1), CYP4F2(17), CYP4F3(25), EPX(9), GGT1(8), LPO(20), LTA4H(5), MPO(12), PLA2G1B(1), PLA2G2A(2), PLA2G2E(5), PLA2G3(19), PLA2G4A(16), PLA2G5(2), PLA2G6(13), PRDX1(3), PRDX2(3), PRDX6(4), PTGDS(3), PTGES2(1), PTGIS(18), PTGS1(20), PTGS2(13), TBXAS1(16), TPO(47) 11883679 325 126 316 181 223 29 5 25 42 1 0.0235 1.000 1.000 194 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AADAT(5), AASDHPPT(3), AASS(3), ACAT2(1), AKR1B10(10), ALDH1A3(2), ALDH1B1(11), ALDH2(6), ALDH3A1(10), ALDH3A2(3), ALDH7A1(10), ALDH9A1(3), BBOX1(7), DLST(1), DOT1L(12), ECHS1(3), EHHADH(6), EHMT1(11), EHMT2(9), GCDH(6), HADH(3), HADHA(6), HSD17B10(2), HSD17B4(6), HSD3B7(5), NSD1(21), OGDH(9), OGDHL(44), PIPOX(7), PLOD1(6), PLOD2(7), PLOD3(5), RDH11(2), RDH12(2), RDH13(3), RDH14(1), SETD1A(27), SETD7(2), SETDB1(10), SHMT1(2), SHMT2(3), SUV39H1(1), SUV39H2(2), TMLHE(2) 24660651 300 124 291 151 193 26 16 39 25 1 0.184 1.000 1.000 195 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(6), ARG1(2), ARG2(2), ASL(7), ASS1(8), CKM(3), CKMT1A(1), CKMT2(5), CPS1(29), DAO(12), EPRS(13), GAMT(4), GATM(6), GLUD1(2), GLUD2(4), GOT1(6), GOT2(6), LAP3(2), NOS1(77), NOS3(20), OAT(4), OTC(4), P4HA1(10), P4HA2(5), P4HA3(14), PRODH(2), PYCR1(1), PYCR2(1), RARS(7), RARS2(4) 15270113 267 124 253 144 177 26 11 19 32 2 0.208 1.000 1.000 196 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ACY3(4), ALDH1A3(2), ALDH1B1(11), ALDH2(6), ALDH3A1(10), ALDH3A2(3), ALDH3B1(3), ALDH3B2(8), ALDH7A1(10), ALDH9A1(3), AMDHD1(6), AOC2(9), AOC3(9), ASPA(3), CARM1(7), CNDP1(10), DDC(16), FTCD(3), HAL(14), HARS(8), HARS2(4), HDC(25), HEMK1(4), HNMT(2), LCMT1(4), LCMT2(1), MAOA(4), MAOB(13), METTL2B(5), METTL6(2), PRMT2(2), PRMT3(5), PRMT5(7), PRMT7(4), PRMT8(10), PRPS1(3), PRPS2(3), UROC1(13), WBSCR22(2) 16840005 258 124 248 165 157 23 14 27 35 2 0.669 1.000 1.000 197 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(3), ADRBK2(7), ARRB2(7), CALM1(1), CALM2(1), CALML3(9), CALML6(1), CAMK2A(6), CAMK2B(6), CAMK2D(6), CAMK2G(5), CLCA1(8), CLCA2(9), CLCA4(30), CNGA3(25), CNGA4(18), CNGB1(23), GNAL(2), GUCA1A(6), GUCA1B(2), GUCA1C(9), PDC(6), PDE1C(54), PRKACA(3), PRKACB(4), PRKACG(10), PRKG1(14), PRKG2(16), PRKX(3) 12882005 294 124 274 163 198 23 9 30 34 0 0.189 1.000 1.000 198 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 33 ACTA1(4), CRK(3), CRKL(2), DOCK1(17), ELK1(3), FOS(2), GAB1(8), GRB2(2), HGF(30), HRAS(3), ITGA1(23), ITGB1(4), JUN(1), MAP2K2(5), MAP4K1(12), MAPK1(4), MAPK3(3), MAPK8(2), MET(23), PAK1(4), PIK3CA(10), PIK3R1(3), PTK2(7), PTK2B(12), PTPN11(10), PXN(2), RAF1(11), RAP1A(1), RAP1B(1), RASA1(5), SOS1(10), SRC(2), STAT3(11) 17944707 240 124 231 134 140 22 9 40 28 1 0.956 1.000 1.000 199 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1A(13), ADRA1B(5), ADRA1D(4), ADRA2A(3), ADRA2C(2), ADRB1(5), ADRB2(4), CHRM1(5), CHRM2(26), CHRM3(26), CHRM4(6), CHRM5(7), DRD1(9), DRD2(16), DRD3(5), DRD4(1), DRD5(25), HRH1(15), HRH2(3), HTR1A(11), HTR1B(2), HTR1D(7), HTR1E(7), HTR1F(9), HTR2A(11), HTR2B(2), HTR2C(14), HTR4(8), HTR5A(19), HTR6(3), HTR7(10) 10790072 283 124 260 227 183 33 11 29 26 1 0.194 1.000 1.000 200 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 47 AKT1(4), AKT2(8), AKT3(3), BRD4(23), CAP1(1), CBL(10), CDC42(2), F2RL2(8), FLOT1(1), GRB2(2), GSK3A(1), GSK3B(3), IGFBP1(3), INPPL1(16), IRS1(5), IRS2(3), IRS4(11), LNPEP(11), MAPK1(4), MAPK3(3), PARD3(20), PARD6A(1), PDK1(2), PIK3CA(10), PIK3CD(8), PIK3R1(3), PTPN1(4), RAF1(11), RPS6KA1(9), RPS6KA2(6), RPS6KA3(2), RPS6KB1(4), SERPINB6(5), SFN(2), SHC1(2), SLC2A4(8), SORBS1(16), SOS1(10), SOS2(13), YWHAB(1), YWHAE(2), YWHAG(2), YWHAQ(3) 24841631 266 124 259 138 147 33 14 43 28 1 0.674 1.000 1.000 201 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(4), AKT2(8), AKT3(3), ARHGEF11(22), BCL2(3), CDC42(2), DLG4(6), GNA13(1), LPA(59), MAP2K4(4), MAP3K1(4), MAP3K5(23), MAPK8(2), NFKB1(6), NFKB2(5), NFKBIA(2), NFKBIB(1), NFKBIL1(2), PDK1(2), PHKA2(9), PI3(6), PIK3CB(10), PLD1(14), PLD2(8), PLD3(1), PTK2(7), RDX(4), ROCK1(6), ROCK2(14), SERPINA4(22), SRF(3), TBXA2R(4) 20876814 267 124 254 153 153 23 11 43 37 0 0.888 1.000 1.000 202 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA1(6), ACAA2(1), ADH1A(17), ADH1B(30), ADH4(12), ADH6(14), ADH7(16), ADHFE1(6), AKR1C4(10), AKR1D1(21), ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(6), ALDH3A1(10), ALDH3A2(3), ALDH9A1(3), BAAT(14), CEL(13), CYP27A1(4), CYP7A1(8), HADHB(6), SOAT2(6), SRD5A1(2) 9931614 244 123 216 101 164 19 15 22 23 1 0.00129 1.000 1.000 203 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 20 CCL11(3), CCR3(11), CFL1(2), GNAQ(6), GNAS(33), GNB1(1), HRAS(3), LIMK1(5), MAPK1(4), MAPK3(3), MYL2(9), NOX1(13), PIK3C2G(56), PLCB1(58), PPP1R12B(9), PRKCA(9), PTK2(7), RAF1(11), ROCK2(14) 10337466 257 123 230 92 176 15 7 34 25 0 0.00278 1.000 1.000 204 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 ACTG1(7), APAF1(6), ARHGDIB(4), BAG4(3), BCL2(3), BIRC2(6), BIRC3(7), CASP2(1), CASP3(2), CASP7(4), CASP8(9), CASP9(2), CFLAR(4), CHUK(2), CRADD(2), CYCS(1), DAXX(10), DFFA(2), DFFB(2), GSN(6), LMNA(5), LMNB1(2), LMNB2(4), MAP2K7(5), MAP3K1(4), MAP3K5(23), MAPK8(2), MDM2(4), NFKB1(6), NFKBIA(2), NUMA1(9), PAK2(9), PRKCD(5), PRKDC(22), PSEN1(3), PSEN2(2), PTK2(7), RASA1(5), RB1(10), RELA(4), RIPK1(3), SPTAN1(10), TNF(1), TNFRSF1A(4), TNFRSF1B(4), TRAF1(6), TRAF2(2) 29446534 246 121 240 134 120 26 15 45 37 3 0.789 1.000 1.000 205 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 32 BLNK(15), BTK(15), CALM1(1), CALM2(1), CD79A(4), ELK1(3), FOS(2), GRB2(2), HRAS(3), JUN(1), LYN(11), MAP3K1(4), MAPK14(5), MAPK3(3), MAPK8(2), NFATC1(17), NFATC2(12), NFATC3(11), NFATC4(18), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKCA(9), RAF1(11), SHC1(2), SOS1(10), SYK(15), SYT1(23), VAV1(19) 15779976 239 120 229 122 154 16 9 29 29 2 0.623 1.000 1.000 206 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(23), ACAT2(1), ACYP1(1), ADH5(3), AKR1B1(2), ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(6), ALDH3A1(10), ALDH3A2(3), ALDH9A1(3), DLAT(4), DLD(3), GLO1(1), GRHPR(1), HAGH(3), LDHA(5), LDHB(2), LDHC(7), LDHD(1), MDH1(3), MDH2(4), ME1(22), ME2(2), ME3(8), PC(14), PCK1(25), PDHA1(4), PDHA2(20), PDHB(1), PKLR(14) 15779632 232 120 223 124 156 15 13 25 22 1 0.374 1.000 1.000 207 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 21 ARFIP2(2), CDK5(6), CDK5R1(1), CFL1(2), CHN1(7), LIMK1(5), MAP3K1(4), MYL2(9), MYLK(48), NCF2(8), PAK1(4), PDGFRA(32), PIK3CA(10), PIK3R1(3), PLD1(14), PPP1R12B(9), RALBP1(3), RPS6KB1(4), TRIO(22), VAV1(19), WASF1(5) 14739970 217 120 206 118 136 15 9 27 28 2 0.622 1.000 1.000 208 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSD(3), ARSE(5), B4GALT6(2), CERK(1), DEGS1(2), DEGS2(5), ENPP7(6), GAL3ST1(11), GALC(3), GBA(7), GLA(2), GLB1(10), LCT(54), NEU1(6), NEU2(19), NEU3(4), NEU4(16), PPAP2B(11), PPAP2C(8), SGMS1(18), SGMS2(1), SGPP1(2), SGPP2(6), SMPD1(2), SMPD2(2), SMPD3(9), SMPD4(6), SPHK1(2), SPHK2(8), SPTLC1(2), SPTLC2(8), UGCG(1), UGT8(8) 15130294 250 119 243 166 173 17 6 30 24 0 0.893 1.000 1.000 209 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 41 BCL2(3), CHUK(2), DAXX(10), EGF(22), EGFR(25), ETS1(4), ETS2(8), FOS(2), HOXA7(2), HRAS(3), IKBKB(4), JUN(1), MAP2K3(9), MAP2K4(4), MAP2K6(3), MAP2K7(5), MAP3K1(4), MAP3K5(23), MAPK1(4), MAPK13(5), MAPK14(5), MAPK3(3), MAPK8(2), NFKB1(6), NFKBIA(2), PPP2CA(1), PRKCA(9), PRKCD(5), PRKCE(7), PRKCG(16), PRKCH(9), PRKCQ(21), RAF1(11), RELA(4), RIPK1(3), SP1(5), TNF(1), TNFRSF1A(4), TNFRSF1B(4), TRAF2(2) 20536783 263 119 256 168 158 25 9 30 41 0 0.932 1.000 1.000 210 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 40 CALM1(1), CALM2(1), CD3D(7), CD3E(2), CD3G(1), ELK1(3), FOS(2), FYN(8), GRB2(2), HRAS(3), JUN(1), LAT(3), LCK(15), MAP2K4(4), MAP3K1(4), MAPK3(3), MAPK8(2), NFATC1(17), NFATC2(12), NFATC3(11), NFATC4(18), NFKB1(6), NFKBIA(2), PIK3CA(10), PIK3R1(3), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKCA(9), PTPN7(2), RAF1(11), RASA1(5), RELA(4), SHC1(2), SOS1(10), SYT1(23), VAV1(19), ZAP70(8) 19831741 254 118 245 125 156 27 10 31 27 3 0.564 1.000 1.000 211 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 ARNT(9), EIF2B1(1), EIF2B2(1), EIF2B3(3), EIF2B4(1), EIF2B5(3), EIF2S1(1), EIF2S3(2), ELAVL1(1), FLT1(42), FLT4(31), HIF1A(4), HRAS(3), KDR(57), NOS3(20), PIK3CA(10), PIK3R1(3), PLCG1(9), PRKCA(9), PTK2(7), PXN(2), SHC1(2), VHL(4) 14545807 225 118 211 114 146 20 3 28 27 1 0.417 1.000 1.000 212 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(19), CALCR(19), CALCRL(19), CD97(7), CRHR1(7), CRHR2(5), ELTD1(27), EMR1(33), EMR2(6), GHRHR(6), GIPR(4), GLP1R(13), GLP2R(15), GPR64(4), LPHN1(7), LPHN2(49), LPHN3(24), SCTR(8), VIPR1(7), VIPR2(7) 11248894 286 117 266 187 203 21 8 16 38 0 0.310 1.000 1.000 213 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 AGA(5), ARSB(3), FUCA1(3), GALNS(5), GBA(7), GLB1(10), GNS(2), GUSB(5), HEXA(5), HEXB(4), HGSNAT(5), HPSE(10), HPSE2(5), HYAL1(2), HYAL2(1), IDS(9), IDUA(6), LCT(54), MAN2B1(9), MAN2B2(10), MAN2C1(4), MANBA(7), NAGLU(4), NEU1(6), NEU2(19), NEU3(4), NEU4(16), SPAM1(28) 14580267 248 117 244 136 172 21 5 25 24 1 0.324 1.000 1.000 214 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 ALAD(5), BLVRA(2), BLVRB(1), CP(14), CPOX(4), EPRS(13), FECH(3), GUSB(5), HCCS(2), HMBS(1), HMOX1(1), HMOX2(1), PPOX(3), UGT1A1(12), UGT1A10(18), UGT1A3(14), UGT1A4(10), UGT1A5(10), UGT1A6(15), UGT1A7(12), UGT1A9(16), UGT2B15(31), UGT2B4(35), UROS(1) 11766354 229 117 208 103 156 20 12 14 25 2 0.0390 1.000 1.000 215 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 28 DPM2(1), EGFR(25), ELK1(3), GNAS(33), GNB1(1), GRB2(2), HRAS(3), IGF1R(15), ITGB1(4), KLK2(5), MAP2K2(5), MAPK1(4), MAPK3(3), MKNK1(6), MKNK2(4), MYC(5), NGFR(8), PDGFRA(32), PPP2CA(1), PTPRR(30), RAF1(11), RPS6KA1(9), RPS6KA5(7), SHC1(2), SOS1(10), SRC(2), STAT3(11) 13708902 242 116 231 111 147 27 12 38 18 0 0.157 1.000 1.000 216 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(11), ACAA1(6), ACAA2(1), ACADM(5), ACADS(5), ACAT2(1), ALDH1A3(2), ALDH1B1(11), ALDH2(6), ALDH3A1(10), ALDH3A2(3), ALDH6A1(4), ALDH7A1(10), ALDH9A1(3), AOX1(29), AUH(2), BCAT1(13), BCAT2(1), BCKDHA(1), BCKDHB(1), DBT(3), DLD(3), ECHS1(3), EHHADH(6), HADH(3), HADHA(6), HADHB(6), HIBADH(5), HIBCH(1), HMGCL(4), HMGCS1(2), HMGCS2(18), HSD17B10(2), HSD17B4(6), IVD(5), MCCC1(5), MCCC2(3), MCEE(2), MUT(5), OXCT1(4), OXCT2(5), PCCA(5), PCCB(3) 18392272 230 116 221 115 148 19 14 25 24 0 0.427 1.000 1.000 217 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(4), ALG10(6), ALG10B(4), ALG11(5), ALG12(1), ALG13(10), ALG14(2), ALG2(5), ALG3(4), ALG5(3), ALG6(2), ALG8(7), ALG9(5), B4GALT1(2), B4GALT2(2), B4GALT3(3), DAD1(1), DDOST(2), DHDDS(1), DOLPP1(3), DPAGT1(2), DPM1(1), FUT8(8), GANAB(6), MAN1A1(19), MAN1A2(7), MAN1B1(4), MAN1C1(11), MAN2A1(10), MGAT1(3), MGAT2(3), MGAT3(12), MGAT4A(8), MGAT4B(1), MGAT5(6), MGAT5B(11), RFT1(5), RPN2(4), ST6GAL1(8), STT3B(5) 18038343 206 116 199 109 120 22 14 21 28 1 0.285 1.000 1.000 218 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 5 C3(55), C5(23), C6(72), C7(49), C9(22) 4796342 221 115 195 88 165 6 6 21 19 4 0.0108 1.000 1.000 219 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA1(7), ANXA2(2), ANXA3(4), ANXA4(2), ANXA5(1), ANXA6(6), CYP11A1(14), EDN1(9), EDNRA(11), EDNRB(7), HPGD(1), HSD11B1(14), HSD11B2(2), PLA2G4A(16), PRL(3), PTGDR(12), PTGDS(3), PTGER2(7), PTGER4(3), PTGFR(21), PTGIR(5), PTGIS(18), PTGS1(20), PTGS2(13), S100A6(1), SCGB1A1(1), TBXAS1(16) 8729408 219 115 210 88 149 22 6 19 22 1 0.000106 1.000 1.000 220 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR2(3), ACTR3(2), ARHGAP1(3), ARHGAP4(4), ARHGAP5(13), ARHGAP6(10), ARHGEF1(1), ARHGEF11(22), ARHGEF5(17), ARPC1B(3), ARPC2(1), ARPC3(2), ARPC4(1), BAIAP2(8), CFL1(2), DIAPH1(10), GSN(6), LIMK1(5), MYL2(9), MYLK(48), OPHN1(4), PIP5K1A(6), PIP5K1B(21), PPP1R12B(9), ROCK1(6), SRC(2), TLN1(12), VCL(9) 19184854 239 115 229 125 170 13 10 23 23 0 0.168 1.000 1.000 221 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 36 AGXT(12), ALAS1(2), ALAS2(6), AMT(1), AOC2(9), AOC3(9), ATP6V0C(1), BHMT(8), CBS(7), CHDH(8), CHKA(2), CHKB(3), CPT1B(9), CTH(1), DAO(12), DLD(3), DMGDH(16), GAMT(4), GARS(6), GATM(6), GCAT(4), GLDC(6), MAOA(4), MAOB(13), PEMT(2), PISD(2), PLCB2(12), PLCG1(9), PLCG2(30), PSPH(2), SARDH(20), SARS(5), SHMT1(2), SHMT2(3), TARS(5) 17475585 244 114 237 155 162 19 11 19 33 0 0.568 1.000 1.000 222 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2A1(2), GTF2A1L(18), GTF2A2(1), GTF2B(5), GTF2E1(3), GTF2E2(6), GTF2F1(5), GTF2F2(2), GTF2H1(3), GTF2H3(1), GTF2H4(2), GTF2I(2), GTF2IRD1(12), STON1(22), TAF1(14), TAF13(1), TAF1L(57), TAF2(9), TAF4(11), TAF4B(7), TAF5L(4), TAF6(3), TAF6L(4), TAF7(3), TAF7L(12), TAF9(2), TAF9B(1), TBPL1(1), TBPL2(7) 15433182 220 113 213 96 151 17 9 24 19 0 0.239 1.000 1.000 223 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 22 ATF2(6), BCR(14), BLNK(15), ELK1(3), FOS(2), GRB2(2), HRAS(3), JUN(1), LYN(11), MAP3K1(4), MAPK1(4), MAPK3(3), MAPK8IP3(9), PAPPA(59), RPS6KA1(9), RPS6KA3(2), SHC1(2), SOS1(10), SYK(15), VAV1(19), VAV2(5), VAV3(11) 13063413 209 113 200 144 142 16 4 21 24 2 0.982 1.000 1.000 224 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(6), CAMK2B(6), CAMK2D(6), CAMK2G(5), DAG1(9), ITPKB(11), ITPR1(36), ITPR2(20), ITPR3(12), NFAT5(11), PDE6A(15), PDE6B(16), PDE6C(25), PDE6D(2), PDE6G(2), SLC6A13(30), TF(16) 15180327 228 113 213 135 156 11 6 19 36 0 0.209 1.000 1.000 225 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CD14(6), CHUK(2), ELK1(3), FOS(2), IKBKB(4), IRAK1(5), JUN(1), LY96(4), MAP2K3(9), MAP2K4(4), MAP2K6(3), MAP3K1(4), MAP3K7(1), MAPK14(5), MAPK8(2), MYD88(1), NFKB1(6), NFKBIA(2), PPARA(8), RELA(4), TIRAP(1), TLR10(13), TLR2(15), TLR3(11), TLR4(42), TLR6(7), TLR7(17), TLR9(14), TOLLIP(1), TRAF6(4) 15464628 201 113 194 101 134 19 8 21 19 0 0.212 1.000 1.000 226 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 33 ADCY1(34), CALM1(1), CALM2(1), ELK1(3), FOS(2), GNAI1(2), GNAQ(6), GNAS(33), GNB1(1), HRAS(3), JUN(1), MAPK3(3), NFATC1(17), NFATC2(12), NFATC3(11), NFATC4(18), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCA(9), RAF1(11), RPS6KA3(2), SYT1(23) 14507453 240 112 227 128 150 25 13 28 23 1 0.630 1.000 1.000 227 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(4), AARS2(3), CARS(9), CARS2(4), DARS(4), DARS2(3), EARS2(2), EPRS(13), FARS2(6), FARSA(8), FARSB(5), GARS(6), HARS(8), HARS2(4), IARS(10), IARS2(18), KARS(4), LARS(13), LARS2(5), MARS(8), MARS2(4), MTFMT(2), NARS(2), NARS2(6), QARS(6), RARS(7), RARS2(4), SARS(5), SARS2(3), TARS(5), TARS2(7), VARS(16), VARS2(7), WARS(5), WARS2(4), YARS(3), YARS2(2) 23310231 225 112 213 124 132 24 9 25 33 2 0.680 1.000 1.000 228 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(15), DLG4(6), EPHB2(36), F2(13), F2RL1(9), F2RL2(8), F2RL3(5), JUN(1), MAP2K5(5), MAPK1(4), MAPK7(4), MAPK8(2), MYEF2(4), PLD1(14), PLD2(8), PLD3(1), PTK2(7), RAF1(11), RASAL1(18), SRC(2), TEC(13), VAV1(19) 11671726 205 112 197 142 120 23 6 30 23 3 0.971 1.000 1.000 229 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 31 ACVR1(2), APC(27), ATF2(6), AXIN1(10), BMP10(14), BMP2(7), BMP4(5), BMP5(33), BMP7(5), BMPR1A(2), BMPR2(7), CHRD(21), DVL1(1), FZD1(5), GATA4(5), GSK3B(3), MAP3K7(1), MEF2C(3), MYL2(9), NKX2-5(1), NOG(2), NPPA(5), NPPB(6), RFC1(5), TGFB1(2), TGFB2(3), TGFB3(3), TGFBR2(9), TGFBR3(9), WNT1(2) 14755505 213 111 196 104 143 18 6 18 28 0 0.429 1.000 1.000 230 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 32 AARS(4), AARS2(3), ABAT(11), ACY3(4), ADSL(6), ADSS(2), ADSSL1(9), AGXT(12), ASL(7), ASNS(9), ASPA(3), ASRGL1(6), ASS1(8), CAD(18), CRAT(5), DARS(4), DARS2(3), DDO(9), DLAT(4), DLD(3), GAD1(14), GAD2(9), GOT1(6), GOT2(6), GPT(4), GPT2(2), NARS(2), NARS2(6), PC(14), PDHA1(4), PDHA2(20), PDHB(1) 15732636 218 111 210 124 144 22 12 18 22 0 0.383 1.000 1.000 231 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ALDH1A3(2), ALDH3A1(10), ALDH3B1(3), ALDH3B2(8), AOC2(9), AOC3(9), DDC(16), EPX(9), GOT1(6), GOT2(6), HPD(7), LPO(20), MAOA(4), MAOB(13), MPO(12), PRDX1(3), PRDX2(3), PRDX6(4), TAT(21), TPO(47) 9341657 212 111 206 144 145 21 7 12 27 0 0.517 1.000 1.000 232 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(25), CD2(29), CD33(21), CD5(8), CD7(2), CSF2(2), IFNA1(1), IFNB1(6), IFNG(4), IL10(2), IL12A(4), IL12B(3), IL13(2), IL3(3), IL4(1), IL5(4), ITGAX(25), TLR2(15), TLR4(42), TLR7(17), TLR9(14) 7912106 230 110 213 118 162 21 10 14 23 0 0.000537 1.000 1.000 233 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(36), ACE2(6), AGT(8), AGTR1(10), AGTR2(10), ANPEP(25), CMA1(6), CPA3(23), CTSA(4), CTSG(5), ENPEP(46), LNPEP(11), MAS1(4), MME(25), NLN(5), REN(12), THOP1(6) 8991146 242 110 226 123 168 20 11 14 28 1 0.0250 1.000 1.000 234 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 34 ACTA1(4), ACTN1(8), ACTN2(21), BCAR1(5), BCR(14), CAPN1(5), CAPNS1(2), CAPNS2(1), CAV1(1), CRKL(2), CSK(1), FYN(8), GRB2(2), HRAS(3), ITGA1(23), ITGB1(4), JUN(1), MAP2K2(5), MAPK1(4), MAPK3(3), MAPK8(2), PPP1R12B(9), PTK2(7), PXN(2), RAF1(11), RAP1A(1), ROCK1(6), SHC1(2), SOS1(10), SRC(2), TLN1(12), VCL(9), ZYX(8) 19573048 198 110 194 113 104 26 12 29 26 1 0.689 1.000 1.000 235 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(2), GUSB(5), UCHL1(5), UCHL3(2), UGDH(1), UGT1A1(12), UGT1A10(18), UGT1A3(14), UGT1A4(10), UGT1A5(10), UGT1A6(15), UGT1A7(12), UGT1A9(16), UGT2B15(31), UGT2B4(35) 7546020 188 110 164 92 133 17 11 8 18 1 0.0607 1.000 1.000 236 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT1(4), AKT2(8), AKT3(3), CISH(4), GRB2(2), IARS(10), IL13RA1(4), IL2RG(3), IL4(1), IL4R(18), INPP5D(36), JAK1(7), JAK2(8), JAK3(11), NR0B2(6), PI3(6), PIK3CA(10), PPP1R13B(9), RPS6KB1(4), SERPINA4(22), SHC1(2), SOS1(10), SOS2(13), SRC(2), STAT6(9), TYK2(8) 15692547 220 110 209 110 142 17 9 29 22 1 0.462 1.000 1.000 237 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA1(6), ACAA2(1), ACADL(5), ACADM(5), ACADS(5), ACADSB(6), ACAT2(1), ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(6), ALDH3A1(10), ALDH3A2(3), ALDH6A1(4), ALDH9A1(3), AOX1(29), BCAT1(13), BCKDHA(1), BCKDHB(1), ECHS1(3), EHHADH(6), HADHA(6), HADHB(6), HIBADH(5), HMGCL(4), IVD(5), MCCC1(5), MCCC2(3), MCEE(2), MUT(5), OXCT1(4), PCCA(5), PCCB(3), SDS(3) 15396124 200 110 191 101 130 15 10 22 23 0 0.444 1.000 1.000 238 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ALDH1A3(2), ALDH3A1(10), ALDH3B1(3), ALDH3B2(8), AOC2(9), AOC3(9), DDC(16), EPX(9), ESCO1(2), ESCO2(4), GOT1(6), GOT2(6), HPD(7), LPO(20), MAOA(4), MAOB(13), MPO(12), NAT6(5), PNPLA3(3), PRDX6(4), SH3GLB1(2), TAT(21), TPO(47) 14603732 222 109 216 157 151 20 11 14 26 0 0.954 1.000 1.000 239 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(11), ALDH1A3(2), ALDH1B1(11), ALDH2(6), ALDH3A1(10), ALDH3A2(3), ALDH7A1(10), ALDH9A1(3), CYP2C19(40), CYP2C9(41), DHRS1(3), DHRS2(8), DHRS3(5), DHRS7(1), DHRSX(6), ECHS1(3), EHHADH(6), ESCO1(2), ESCO2(4), HADHA(6), NAT6(5), PNPLA3(3), SH3GLB1(2), YOD1(1) 13220609 192 109 181 122 119 20 14 17 22 0 0.918 1.000 1.000 240 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 20 F2(13), F2R(8), F2RL3(5), GNAI1(2), GNB1(1), HRAS(3), ITGA1(23), ITGB1(4), MAPK1(4), MAPK3(3), PLA2G4A(16), PLCB1(58), PRKCA(9), PTGS1(20), PTK2(7), RAF1(11), SRC(2), SYK(15), TBXAS1(16) 10041621 220 108 206 99 147 18 6 24 24 1 0.0720 1.000 1.000 241 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(16), CARM1(7), CCND1(2), CREBBP(24), EP300(19), ERCC3(6), ESR1(6), GRIP1(13), GTF2A1(2), GTF2E1(3), GTF2F1(5), HDAC1(2), HDAC2(2), HDAC3(5), HDAC4(11), HDAC5(6), HDAC6(3), MEF2C(3), NCOR2(28), NR0B1(3), NRIP1(10), PELP1(12), POLR2A(13), TBP(4) 19402795 205 107 203 95 131 11 12 34 17 0 0.311 1.000 1.000 242 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 21 ADCY1(34), AKT1(4), GNAI1(2), GNB1(1), ITGAV(11), ITGB3(16), MAPK1(4), MAPK3(3), PDGFA(1), PDGFRA(32), PIK3CA(10), PIK3R1(3), PLCB1(58), PRKCA(9), PTK2(7), SMPD1(2), SMPD2(2), SPHK1(2), SRC(2) 11555407 203 107 193 94 143 12 7 22 18 1 0.0804 1.000 1.000 243 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(7), ACTG2(6), ADCY3(3), ADCY9(11), AK1(1), ARF4(3), ARF5(2), ARF6(1), ARL4D(2), ATP6V0A1(13), ATP6V0A2(5), ATP6V0A4(23), ATP6V0C(1), ATP6V0D1(1), ATP6V0D2(9), ATP6V0E1(1), ATP6V1A(2), ATP6V1C2(8), ATP6V1E1(1), ATP6V1E2(3), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(7), ATP6V1H(5), ERO1L(5), GNAS(33), PDIA4(5), PLCG1(9), PLCG2(30), PRKCA(9), SEC61A1(3), SEC61A2(2), TRIM23(2) 15808781 215 107 207 131 142 12 9 24 28 0 0.541 1.000 1.000 244 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(4), CAPN1(5), CAPN2(6), CAPNS1(2), CAPNS2(1), CXCR3(4), EGF(22), EGFR(25), HRAS(3), ITGA1(23), ITGB1(4), MAPK1(4), MAPK3(3), MYL2(9), MYLK(48), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PTK2(7), PXN(2), TLN1(12) 13847150 211 107 202 127 140 13 9 19 30 0 0.585 1.000 1.000 245 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(5), ICAM1(2), ITGA4(45), ITGAL(27), ITGAM(25), ITGB1(4), ITGB2(17), SELE(33), SELL(12), SELP(38) 6733714 208 107 196 82 153 6 5 17 25 2 0.00656 1.000 1.000 246 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CD80(4), CR1(53), CR2(35), FCGR2B(3), HLA-DRA(13), HLA-DRB1(5), ICAM1(2), ITGAL(27), ITGB2(17), PTPRC(36) 6426148 195 106 185 77 127 15 7 15 26 5 0.0243 1.000 1.000 247 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(6), ALDH3A1(10), ALDH3A2(3), ALDH3B1(3), ALDH3B2(8), ALDH9A1(3), AOC2(9), AOC3(9), ASPA(3), CNDP1(10), DDC(16), HAL(14), HARS(8), HDC(25), HNMT(2), MAOA(4), MAOB(13), PRPS1(3), PRPS2(3) 10368931 188 106 178 114 115 13 10 20 29 1 0.467 1.000 1.000 248 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 24 GH1(5), GHR(43), GRB2(2), HRAS(3), INSR(23), IRS1(5), JAK2(8), MAPK1(4), MAPK3(3), PIK3CA(10), PIK3R1(3), PLCG1(9), PRKCA(9), PTPN6(5), RAF1(11), RPS6KA1(9), SHC1(2), SLC2A4(8), SOCS1(1), SOS1(10), SRF(3), STAT5A(3), STAT5B(5) 13808726 184 105 174 97 111 16 12 25 19 1 0.514 1.000 1.000 249 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 25 AKT1(4), APC(27), AXIN1(10), CCND1(2), CD14(6), DVL1(1), FZD1(5), GJA1(10), GNAI1(2), GSK3B(3), IRAK1(5), LBP(10), LEF1(3), LY96(4), MYD88(1), NFKB1(6), PDPK1(5), PIK3CA(10), PIK3R1(3), PPP2CA(1), RELA(4), TIRAP(1), TLR4(42), TOLLIP(1), WNT1(2) 12295484 168 105 160 97 110 14 7 18 17 2 0.848 1.000 1.000 250 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(11), ACACA(23), ACACB(23), ACADM(5), ACAT2(1), ACSS1(2), ACSS2(4), ALDH1A3(2), ALDH1B1(11), ALDH2(6), ALDH3A1(10), ALDH3A2(3), ALDH6A1(4), ALDH7A1(10), ALDH9A1(3), ECHS1(3), EHHADH(6), HADHA(6), HIBCH(1), LDHA(5), LDHAL6A(6), LDHAL6B(6), LDHB(2), LDHC(7), MCEE(2), MLYCD(2), MUT(5), PCCA(5), PCCB(3), SUCLG1(4), SUCLG2(3) 16979753 184 105 177 107 107 14 17 23 23 0 0.768 1.000 1.000 251 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 ADCY1(34), AKT1(4), BAX(4), BCL2(3), CSF2RB(24), IGF1(11), IGF1R(15), IL3(3), IL3RA(8), KIT(13), KITLG(10), PIK3CA(10), PIK3R1(3), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5) 9343573 169 104 161 94 105 18 10 16 19 1 0.380 1.000 1.000 252 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 44 AGXT(12), AKR1B10(10), ALAS1(2), ALAS2(6), AMT(1), AOC2(9), AOC3(9), BHMT(8), CBS(7), CHDH(8), CHKA(2), CHKB(3), CTH(1), DAO(12), DLD(3), DMGDH(16), GAMT(4), GARS(6), GATM(6), GCAT(4), GLDC(6), GNMT(1), HSD3B7(5), MAOA(4), MAOB(13), PEMT(2), PHGDH(5), PIPOX(7), PISD(2), PSAT1(4), PSPH(2), RDH11(2), RDH12(2), RDH13(3), RDH14(1), SARDH(20), SARS(5), SARS2(3), SDS(3), SHMT1(2), SHMT2(3), TARS(5), TARS2(7) 17771881 236 104 230 151 160 17 10 15 34 0 0.653 1.000 1.000 253 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 34 AKT1(4), BCL2(3), CBL(10), CFLAR(4), CRKL(2), E2F1(6), FOS(2), GRB2(2), HRAS(3), IL2RA(7), IL2RB(12), IL2RG(3), IRS1(5), JAK1(7), JAK3(11), MAPK1(4), MAPK3(3), MYC(5), NMI(4), PIK3CA(10), PIK3R1(3), PPIA(1), PTPN6(5), RAF1(11), RPS6KB1(4), SHC1(2), SOCS1(1), SOCS3(1), SOS1(10), STAT5A(3), STAT5B(5), SYK(15) 15355772 168 104 163 98 94 20 10 24 19 1 0.844 1.000 1.000 254 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(27), ATP4B(1), ATP5O(5), ATP6AP1(3), ATP6V0A1(13), ATP6V0A4(23), ATP6V0C(1), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(7), ATP6V1H(5), ATP7A(13), ATP7B(23), COX10(7), COX5B(1), COX6A1(1), COX6B1(2), COX6C(1), COX7B(1), COX8A(1), NDUFA10(4), NDUFA4(1), NDUFB2(3), NDUFB5(3), NDUFB6(2), NDUFB7(2), NDUFS1(2), NDUFS2(3), NDUFV1(1), NDUFV2(1), PPA2(4), SDHA(4), SHMT1(2), UQCRC1(4), UQCRFS1(3) 16344614 195 104 193 123 115 12 17 28 21 2 0.895 1.000 1.000 255 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 38 ATF2(6), CDC42(2), DAXX(10), DDIT3(3), ELK1(3), GRB2(2), HMGN1(2), HRAS(3), HSPB1(2), HSPB2(1), MAP2K4(4), MAP2K6(3), MAP3K1(4), MAP3K5(23), MAP3K7(1), MAP3K9(27), MAPK14(5), MAPKAPK2(5), MAPKAPK5(1), MEF2A(3), MEF2B(2), MEF2C(3), MEF2D(6), MKNK1(6), MYC(5), PLA2G4A(16), RIPK1(3), RPS6KA5(7), SHC1(2), STAT1(5), TGFB1(2), TGFB2(3), TGFB3(3), TRAF2(2) 15328745 175 104 170 75 108 14 6 26 21 0 0.238 1.000 1.000 256 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(4), ATF1(5), CDC42(2), CREB5(9), DUSP1(1), DUSP10(9), EEF2K(6), ELK1(3), HSPB1(2), IL1R1(12), MAP2K3(9), MAP2K4(4), MAP2K6(3), MAP3K10(13), MAP3K4(19), MAP3K5(23), MAP3K7(1), MAPK1(4), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MAPKAPK2(5), MAPKAPK5(1), MKNK1(6), MKNK2(4), MYEF2(4), NFKB1(6), NR2C2(1), SRF(3), TRAF6(4) 14189558 175 104 168 100 112 16 3 23 21 0 0.699 1.000 1.000 257 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 ANKHD1(26), EEF1A2(10), EEF1B2(1), EEF1D(2), EEF1G(6), EEF2(3), EEF2K(6), EIF1AX(3), EIF1AY(1), EIF2AK1(4), EIF2AK2(6), EIF2AK3(13), EIF2B1(1), EIF2B2(1), EIF2B3(3), EIF2B4(1), EIF2B5(3), EIF2S1(1), EIF2S3(2), EIF4A1(4), EIF4A2(3), EIF4EBP1(1), EIF4G1(19), EIF4G3(19), EIF5(2), EIF5B(4), ETF1(2), GSPT2(9), PABPC1(5), PABPC3(8), PAIP1(9), SLC35A4(4) 18614061 182 104 181 94 103 22 13 19 25 0 0.726 1.000 1.000 258 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 21 ARHGAP5(13), DIAPH1(10), FYN(8), GSN(6), HRAS(3), ITGA1(23), ITGB1(4), MAPK1(4), MAPK3(3), MYL2(9), MYLK(48), PIK3CA(10), PIK3R1(3), PTK2(7), PXN(2), RAF1(11), ROCK1(6), SHC1(2), SRC(2), TLN1(12) 15559140 186 103 174 95 117 14 7 27 20 1 0.516 1.000 1.000 259 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP1(4), ACP2(3), ACP5(3), ACP6(12), ACPP(9), ACPT(3), ALPI(9), ALPL(11), ALPP(9), ALPPL2(12), CMBL(5), CYP3A4(21), CYP3A43(19), CYP3A5(14), CYP3A7(18), DHRS1(3), DHRS2(8), DHRS3(5), DHRS7(1), DHRSX(6), PON1(14), PON2(3), PON3(7) 7664834 199 103 188 75 146 10 6 12 24 1 5.98e-05 1.000 1.000 260 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(34), CD3D(7), CD3E(2), CD3G(1), CD4(9), CREBBP(24), CSK(1), GNAS(33), GNB1(1), HLA-DRA(13), HLA-DRB1(5), LCK(15), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PTPRC(36), ZAP70(8) 9695157 216 102 206 103 138 22 11 21 23 1 0.116 1.000 1.000 261 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(34), CD3D(7), CD3E(2), CD3G(1), CD4(9), CREBBP(24), CSK(1), GNAS(33), GNB1(1), HLA-DRA(13), HLA-DRB1(5), LCK(15), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PTPRC(36), ZAP70(8) 9695157 216 102 206 103 138 22 11 21 23 1 0.116 1.000 1.000 262 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(2), EXT2(9), EXTL1(4), EXTL3(13), GLCE(8), HS2ST1(1), HS3ST1(11), HS3ST2(8), HS3ST3A1(6), HS3ST3B1(1), HS3ST5(9), HS6ST1(2), HS6ST2(3), HS6ST3(15), NDST1(6), NDST2(2), NDST3(25), NDST4(51) 8709189 176 102 171 96 112 13 8 20 23 0 0.238 1.000 1.000 263 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(27), CAMP(2), CASP3(2), CERK(1), CREB5(9), DAG1(9), EPHB2(36), FOS(2), GNAQ(6), ITPKB(11), JUN(1), MAP2K4(4), MAP2K7(5), MAPK1(4), MAPK10(9), MAPK8(2), MAPK8IP1(7), MAPK8IP2(8), MAPK8IP3(9), MAPK9(4) 12137477 158 102 153 97 103 11 7 17 19 1 0.893 1.000 1.000 264 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 31 A1BG(2), AKT1(4), AKT2(8), AKT3(3), BTK(15), DAPP1(6), GRB2(2), GSK3A(1), GSK3B(3), IARS(10), IGFBP1(3), INPP5D(36), PDK1(2), PIK3CA(10), PPP1R13B(9), RPS6KA1(9), RPS6KA2(6), RPS6KA3(2), RPS6KB1(4), SFN(2), SHC1(2), SOS1(10), SOS2(13), TEC(13), YWHAB(1), YWHAE(2), YWHAG(2), YWHAQ(3) 14749762 183 102 170 80 113 16 10 25 18 1 0.256 1.000 1.000 265 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 AKT1(4), AVP(1), CABIN1(17), CALM1(1), CALM2(1), CAMK1(5), CAMK1G(12), HDAC5(6), IGF1(11), IGF1R(15), INSR(23), MAP2K6(3), MAPK14(5), MAPK7(4), MEF2A(3), MEF2B(2), MEF2C(3), MEF2D(6), MYOD1(1), NFATC1(17), NFATC2(12), PIK3CA(10), PIK3R1(3), PPP3CA(5), PPP3CB(4), PPP3CC(2), SYT1(23) 14860672 199 101 187 113 132 16 10 23 17 1 0.518 1.000 1.000 266 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(34), ARHGEF1(1), F2(13), F2R(8), F2RL3(5), GNA12(3), GNA13(1), GNAI1(2), GNAQ(6), GNB1(1), MAP3K7(1), PIK3CA(10), PIK3R1(3), PLCB1(58), PPP1R12B(9), PRKCA(9), PTK2B(12), ROCK1(6) 11017213 182 101 171 88 120 14 8 23 15 2 0.192 1.000 1.000 267 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 17 CBL(10), EGF(22), EGFR(25), GRB2(2), HRAS(3), MAPK1(4), MAPK3(3), PTPRB(84), RAF1(11), RASA1(5), SHC1(2), SOS1(10), SPRY1(10), SPRY2(3), SPRY3(12), SPRY4(1), SRC(2) 10311862 209 101 195 97 139 20 6 23 21 0 0.386 1.000 1.000 268 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(6), BAX(4), BCL2(3), BCL2A1(2), BCL2L2(3), CASP1(4), CASP10(6), CASP2(1), CASP3(2), CASP4(2), CASP7(4), CASP8(9), CASP9(2), CD40(4), CD40LG(1), CRADD(2), CYCS(1), DAXX(10), DFFA(2), DFFB(2), FAS(5), FASLG(15), IKBKE(9), LTA(5), MCL1(3), NFKB1(6), NFKBIA(2), NGFR(8), NR3C1(7), NTRK1(16), PTPN13(17), RIPK1(3), TFG(1), TNF(1), TNFRSF1A(4), TNFRSF1B(4), TRAF1(6), TRAF2(2), TRAF3(5), TRAF6(4) 18464851 193 100 190 125 119 18 7 24 24 1 0.977 1.000 1.000 269 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(9), ABAT(11), ACADS(5), ACAT2(1), ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(6), ALDH3A1(10), ALDH3A2(3), ALDH5A1(10), ALDH9A1(3), ECHS1(3), EHHADH(6), GAD1(14), GAD2(9), HADHA(6), HMGCL(4), L2HGDH(4), OXCT1(4), PDHA1(4), PDHA2(20), PDHB(1), SDS(3) 11044883 172 100 164 79 108 16 7 20 21 0 0.0724 1.000 1.000 270 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 22 BCAR1(5), CRK(3), CXCL12(2), CXCR4(3), GNAI1(2), GNAQ(6), GNB1(1), HRAS(3), MAPK1(4), MAPK3(3), NFKB1(6), PIK3C2G(56), PIK3CA(10), PIK3R1(3), PLCG1(9), PRKCA(9), PTK2(7), PTK2B(12), PXN(2), RAF1(11), RELA(4) 11370108 161 100 146 92 106 12 6 23 13 1 0.759 1.000 1.000 271 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(2), CDC7(3), CDK2(1), CDT1(2), DIAPH2(8), MCM10(7), MCM2(11), MCM3(9), MCM4(8), MCM5(5), MCM6(5), MCM7(1), NACA(44), PCNA(2), POLA2(9), POLD1(7), POLD2(2), POLD3(7), POLE(16), POLE2(2), PRIM1(3), RFC1(5), RFC2(4), RFC3(1), RPA1(3), RPA2(2), RPA4(2), UBB(1), UBC(6) 21570075 178 100 175 110 121 12 6 25 14 0 0.878 1.000 1.000 272 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ACY1(2), AGMAT(4), ALDH18A1(8), ALDH1A3(2), ALDH1B1(11), ALDH2(6), ALDH3A1(10), ALDH3A2(3), ALDH7A1(10), ALDH9A1(3), AOC2(9), AOC3(9), ARG1(2), ARG2(2), ASL(7), ASS1(8), CPS1(29), GATM(6), MAOA(4), MAOB(13), NAGS(1), ODC1(3), OTC(4), SMS(5), SRM(1) 12448901 162 100 157 95 88 15 10 22 27 0 0.600 1.000 1.000 273 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(13), BCAT2(1), COASY(5), DPYD(73), DPYS(28), ENPP1(13), ENPP3(14), ILVBL(5), PANK1(3), PANK2(5), PANK3(4), PANK4(6), PPCS(3), UPB1(11), VNN1(7) 7364067 191 100 169 55 140 11 3 21 16 0 8.53e-06 1.000 1.000 274 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(15), ABCC2(12), ABCG2(5), BCHE(7), CES1(21), CES2(4), CYP3A4(21), CYP3A5(14), UGT1A1(12), UGT1A10(18), UGT1A3(14), UGT1A4(10), UGT1A5(10), UGT1A6(15), UGT1A7(12), UGT1A9(16) 9767425 206 100 187 88 139 17 11 17 20 2 0.00104 1.000 1.000 275 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(11), ACACA(23), ACADL(5), ACADM(5), ACADSB(6), ACAT2(1), ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(6), ALDH3A1(10), ALDH3A2(3), ALDH6A1(4), ALDH9A1(3), ECHS1(3), EHHADH(6), HADHA(6), LDHA(5), LDHB(2), LDHC(7), MCEE(2), MLYCD(2), MUT(5), PCCA(5), PCCB(3), SDS(3), SUCLG1(4), SUCLG2(3) 14168861 169 100 162 83 105 12 12 23 17 0 0.405 1.000 1.000 276 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 31 AGT(8), AGTR1(10), ATF2(6), CALM1(1), CALM2(1), EGFR(25), ELK1(3), GNAQ(6), GRB2(2), HRAS(3), JUN(1), MAP2K2(5), MAP2K4(4), MAP3K1(4), MAPK1(4), MAPK3(3), MAPK8(2), MEF2A(3), MEF2B(2), MEF2C(3), MEF2D(6), PAK1(4), PRKCA(9), PTK2(7), PTK2B(12), RAF1(11), SHC1(2), SOS1(10), SRC(2), SYT1(23) 13740076 182 99 172 116 113 17 10 24 17 1 0.977 1.000 1.000 277 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(8), F2(13), F2R(8), F3(2), F5(39), F7(7), FGA(41), FGB(10), FGG(10), PROC(11), PROS1(17), SERPINC1(7), TFPI(7) 6998214 180 98 166 74 121 20 8 19 11 1 0.0979 1.000 1.000 278 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(2), AKR1B10(10), ALDOA(1), ALDOB(14), ALDOC(4), FBP1(3), FBP2(2), FPGT(3), FUK(5), GMDS(5), GMPPA(1), GMPPB(4), HK1(3), HK2(15), HK3(15), HSD3B7(5), KHK(2), LHPP(1), MPI(1), MTMR1(6), MTMR2(3), MTMR6(2), PFKFB1(4), PFKFB2(5), PFKFB3(4), PFKFB4(7), PFKL(3), PFKP(2), PGM2(7), PMM1(4), PMM2(3), RDH11(2), RDH12(2), RDH13(3), RDH14(1), SORD(2), TPI1(1), TSTA3(4) 15743248 161 98 157 117 102 14 12 17 16 0 0.859 1.000 1.000 279 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOA(1), ALDOB(14), ALDOC(4), FBP1(3), FBP2(2), GOT1(6), GOT2(6), GPT(4), GPT2(2), MDH1(3), MDH2(4), ME1(22), ME3(8), PGK1(3), PGK2(36), PKLR(14), TKT(6), TKTL1(3), TKTL2(28), TPI1(1) 8638255 170 98 157 95 124 17 5 13 10 1 0.0732 1.000 1.000 280 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 BCL2(3), CREBBP(24), EP300(19), FYN(8), IL2RG(3), IL7(5), IL7R(37), JAK1(7), JAK3(11), LCK(15), NMI(4), PIK3CA(10), PIK3R1(3), PTK2B(12), STAT5A(3), STAT5B(5) 11900062 169 98 164 83 101 19 8 23 16 2 0.428 1.000 1.000 281 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 25 ADCY1(34), AKT1(4), CAMK2A(6), CAMK2B(6), CAMK2D(6), CAMK2G(5), GNAS(33), GRB2(2), HRAS(3), MAPK1(4), MAPK14(5), MAPK3(3), PIK3CA(10), PIK3R1(3), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCA(9), RPS6KA1(9), RPS6KA5(7), SOS1(10) 12178266 186 97 179 107 118 19 9 19 20 1 0.792 1.000 1.000 282 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(1), F13A1(26), F2(13), F2R(8), FGA(41), FGB(10), FGG(10), PLAT(5), PLG(36), SERPINB2(20), SERPINE1(6) 5693092 176 97 167 65 124 11 10 18 12 1 0.0223 1.000 1.000 283 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 21 ATM(16), ATR(22), BRCA1(16), CDC25A(8), CDC25B(4), CDC25C(5), CDC34(4), CDKN1A(3), CHEK1(2), CHEK2(2), EP300(19), MDM2(4), MYT1(21), PRKDC(22), RPS6KA1(9), WEE1(2), YWHAQ(3) 17533576 162 97 159 76 98 14 8 29 13 0 0.674 1.000 1.000 284 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(2), IFNA1(1), IFNB1(6), IKBKB(4), IL1A(5), IL1B(8), IL1R1(12), IL1RAP(3), IL1RN(8), IL6(2), IRAK1(5), IRAK2(15), IRAK3(11), JUN(1), MAP2K3(9), MAP2K6(3), MAP3K1(4), MAP3K7(1), MAPK14(5), MAPK8(2), MYD88(1), NFKB1(6), NFKBIA(2), RELA(4), TGFB1(2), TGFB2(3), TGFB3(3), TNF(1), TOLLIP(1), TRAF6(4) 12575253 134 97 129 75 86 12 4 13 19 0 0.542 1.000 1.000 285 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 13 APC(27), AXIN1(10), CREBBP(24), DVL1(1), EP300(19), FZD1(5), GSK3B(3), HDAC1(2), LDB1(3), LEF1(3), PITX2(6), TRRAP(47), WNT1(2) 13494575 152 97 147 93 87 15 9 20 20 1 0.969 1.000 1.000 286 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(17), ADH1B(30), ADH4(12), ADH5(3), ADH6(14), ADH7(16), ADHFE1(6), ALDH1A3(2), ALDH1B1(11), ALDH2(6), ALDH3A1(10), ALDH3A2(3), ALDH7A1(10), ALDH9A1(3) 5638748 143 96 124 50 102 9 11 11 10 0 0.000650 1.000 1.000 287 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(13), COASY(5), DPYD(73), DPYS(28), ENPP1(13), ENPP3(14), PANK1(3), PANK2(5), PANK3(4), PANK4(6), PPCS(3), UPB1(11) 5933233 178 96 156 50 128 11 3 21 15 0 5.83e-05 1.000 1.000 288 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(6), AKT1(4), AKT2(8), AKT3(3), DAG1(9), GNAQ(6), ITPKB(11), ITPR1(36), ITPR2(20), ITPR3(12), NFKB1(6), NFKB2(5), NFKBIA(2), NFKBIB(1), NFKBIL1(2), PDK1(2), PHKA2(9), PIK3CB(10), PITX2(6), PLD1(14), PLD2(8), PLD3(1), VN1R1(1) 19078956 182 96 174 124 102 17 13 28 22 0 0.889 1.000 1.000 289 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 40 APAF1(6), BAK1(2), BAX(4), BCL2(3), BIRC2(6), BIRC3(7), CASP2(1), CASP3(2), CASP7(4), CASP8(9), CASP9(2), CYCS(1), FAS(5), FASLG(15), GZMB(3), JUN(1), MAP2K4(4), MAP3K1(4), MAPK10(9), MCL1(3), MDM2(4), MYC(5), NFKB1(6), NFKBIA(2), PARP1(7), PRF1(14), RELA(4), RIPK1(3), TNF(1), TNFRSF1A(4), TNFRSF1B(4), TNFSF10(9), TRAF1(6), TRAF2(2) 15536074 162 95 160 79 93 18 10 19 22 0 0.388 1.000 1.000 290 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 AANAT(1), ACHE(9), CHAT(20), COMT(4), DBH(16), DDC(16), GAD1(14), GAD2(9), HDC(25), MAOA(4), PAH(12), PNMT(4), SLC18A3(2), TH(11), TPH1(12) 6036350 159 95 150 97 113 14 6 6 19 1 0.197 1.000 1.000 291 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 ARNTL(7), AZIN1(1), BTG1(5), CBX3(2), CLOCK(4), CRY1(7), CRY2(7), EIF4G2(6), ETV6(10), GFRA1(8), GSTM3(4), GSTP1(3), HERPUD1(2), HSPA8(5), IDI1(1), KLF9(3), MYF6(15), NCKAP1(5), NCOA4(4), NR1D2(11), PER1(8), PER2(12), PIGF(2), PPP1R3C(4), PPP2CB(2), PSMA4(4), PURA(2), SF3A3(7), SUMO3(2), TOB1(3), TUBB3(4), UCP3(6), UGP2(1), VAPA(2), ZFR(10) 15560924 179 95 176 82 92 18 16 32 21 0 0.592 1.000 1.000 292 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 21 AKT1(4), EIF4A1(4), EIF4A2(3), EIF4EBP1(1), EIF4G1(19), EIF4G2(6), EIF4G3(19), GHR(43), IRS1(5), MAPK1(4), MAPK14(5), MAPK3(3), MKNK1(6), PABPC1(5), PDK2(4), PDPK1(5), PIK3CA(10), PIK3R1(3), PRKCA(9), RPS6KB1(4) 11724819 162 95 152 62 98 19 8 16 20 1 0.0690 1.000 1.000 293 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSB(3), ARSD(3), ARSE(5), GAL3ST1(11), GALC(3), GBA(7), GLA(2), GLB1(10), LCT(54), NEU1(6), NEU2(19), NEU3(4), NEU4(16), PPAP2B(11), PPAP2C(8), SMPD1(2), SMPD2(2), SPTLC1(2), SPTLC2(8), UGCG(1) 10226157 177 95 172 111 119 15 3 22 18 0 0.827 1.000 1.000 294 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(11), ALDH4A1(6), ALDH5A1(10), CAD(18), CPS1(29), EARS2(2), EPRS(13), GAD1(14), GAD2(9), GCLC(5), GCLM(2), GFPT1(6), GFPT2(9), GLS(2), GLS2(3), GLUD1(2), GLUD2(4), GLUL(1), GMPS(6), GOT1(6), GOT2(6), GPT(4), GPT2(2), GSR(2), GSS(9), NADSYN1(4), NAGK(1), QARS(6) 16849083 192 95 185 108 111 23 11 27 19 1 0.594 1.000 1.000 295 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(18), ANAPC10(1), ANAPC2(7), ANAPC4(6), ANAPC5(5), ANAPC7(6), BTRC(4), CDC20(1), CDC23(4), CDC27(14), CUL1(3), CUL2(4), CUL3(5), FBXW11(6), FBXW7(11), FZR1(8), ITCH(9), SKP2(2), SMURF1(2), SMURF2(9), TCEB1(1), TCEB2(1), UBA1(3), UBE2D1(1), UBE2D3(3), UBE2E1(1), UBE2E2(4), UBE2E3(1), VHL(4), WWP1(7), WWP2(9) 16992013 160 95 155 75 102 8 8 18 23 1 0.700 1.000 1.000 296 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AADAT(5), AASDH(5), AASDHPPT(3), AASS(3), ACAT2(1), ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(6), ALDH3A1(10), ALDH3A2(3), ALDH9A1(3), ATP6V0C(1), BBOX1(7), DLST(1), DOT1L(12), ECHS1(3), EHHADH(6), EHMT1(11), EHMT2(9), GCDH(6), HADHA(6), PLOD1(6), PLOD2(7), PLOD3(5), SDS(3), SHMT1(2), SHMT2(3), TMLHE(2) 15709863 165 95 159 97 105 17 6 21 15 1 0.603 1.000 1.000 297 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(7), BAIAP2(8), CASP1(4), CASP3(2), CASP7(4), CASP8(9), GAPDH(2), INSR(23), ITCH(9), MAGI1(38), MAGI2(24), RERE(25), WWP1(7), WWP2(9) 10275967 171 93 166 78 114 12 6 17 21 1 0.310 1.000 1.000 298 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(6), ESR2(10), PDE1A(44), PDE1B(15), PLCB1(58), PLCB2(12), PRL(3), TRH(4), VIP(5) 4695304 157 93 137 66 120 5 2 14 16 0 0.00410 1.000 1.000 299 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 ARHGDIB(4), CASP10(6), CASP3(2), CASP7(4), CASP8(9), CFLAR(4), DAXX(10), DFFA(2), DFFB(2), FAF1(9), JUN(1), LMNA(5), LMNB1(2), LMNB2(4), MAP2K4(4), MAP3K1(4), MAP3K7(1), MAPK8(2), PAK1(4), PAK2(9), PRKDC(22), PTPN13(17), RB1(10), RIPK2(3), SPTAN1(10) 17418966 150 92 149 85 68 13 12 32 23 2 0.962 1.000 1.000 300 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 32 DUSP1(1), GORASP1(1), MAP2K4(4), MAP2K7(5), MAPK1(4), MAPK10(9), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MAPK3(3), MAPK8(2), MAPK8IP1(7), MAPK8IP2(8), MAPK8IP3(9), MAPK9(4), MAPKAPK5(1), NFKB1(6), NFKB2(5), NFKBIA(2), NFKBIB(1), NFKBIL1(2), PIK3CA(10), PIK3CD(8), PIK3R1(3), SYT1(23), TRAF2(2), TRAF3(5), TRAF5(8), TRAF6(4) 14273666 149 92 143 103 100 9 7 19 13 1 0.910 1.000 1.000 301 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(34), ADRB2(4), CFTR(62), GNAS(33), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), SLC9A3R1(2) 5542558 162 91 150 90 108 14 7 14 18 1 0.448 1.000 1.000 302 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 26 ACLY(12), ACO1(8), ACO2(5), CLYBL(5), CS(2), DLD(3), DLST(1), FH(3), IDH2(2), IDH3A(3), IDH3B(2), IDH3G(2), MDH1(3), MDH2(4), OGDH(9), OGDHL(44), PC(14), PCK1(25), PCK2(6), SDHA(4), SDHC(3), SDHD(1), SUCLG1(4), SUCLG2(3) 12416508 168 91 162 92 109 6 7 25 21 0 0.349 1.000 1.000 303 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(13), ARHGEF1(1), GNA12(3), GNA13(1), GNAQ(6), GNB1(1), MYL2(9), MYLK(48), PLCB1(58), PPP1R12B(9), PRKCA(9), ROCK1(6) 8853425 164 91 146 72 119 2 7 19 17 0 0.109 1.000 1.000 304 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(34), ADRB2(4), GNAS(33), PLCE1(56), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5) 6249260 154 91 147 79 100 17 10 14 13 0 0.339 1.000 1.000 305 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 CDK5(6), CDK5R1(1), DAB1(48), FYN(8), LRP8(3), RELN(90), VLDLR(5) 5963173 161 91 154 89 114 9 3 16 18 1 0.888 1.000 1.000 306 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 25 CSNK2A1(2), EGF(22), EGFR(25), ELK1(3), FOS(2), GRB2(2), HRAS(3), JAK1(7), JUN(1), MAP2K4(4), MAP3K1(4), MAPK3(3), MAPK8(2), PIK3CA(10), PIK3R1(3), PLCG1(9), PRKCA(9), RAF1(11), RASA1(5), SHC1(2), SOS1(10), SRF(3), STAT1(5), STAT3(11), STAT5A(3) 15637529 161 90 158 91 88 17 8 29 18 1 0.940 1.000 1.000 307 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(3), GALNS(5), GLB1(10), GNS(2), GUSB(5), HEXA(5), HEXB(4), HGSNAT(5), HPSE(10), HPSE2(5), HYAL1(2), HYAL2(1), IDS(9), IDUA(6), LCT(54), NAGLU(4), SPAM1(28) 8678408 158 90 154 96 114 10 3 15 16 0 0.690 1.000 1.000 308 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCR1(10), CCR2(17), CCR3(11), CCR4(9), CCR5(10), CCR7(4), CD28(2), CD4(9), CSF2(2), CXCR3(4), CXCR4(3), IFNG(4), IFNGR1(3), IFNGR2(4), IL12A(4), IL12B(3), IL12RB1(15), IL12RB2(3), IL18R1(21), IL2(4), IL4(1), IL4R(18), IL5(4), TGFB1(2), TGFB2(3), TGFB3(3) 8508318 173 90 162 95 126 12 2 13 20 0 0.0378 1.000 1.000 309 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(6), BCL2(3), BIRC2(6), BIRC3(7), CASP10(6), CASP3(2), CASP7(4), CASP8(9), CASP9(2), CFLAR(4), CHUK(2), CYCS(1), DFFA(2), DFFB(2), GAS2(14), LMNA(5), NFKB1(6), NFKBIA(2), RELA(4), RIPK1(3), SPTAN1(10), TNFRSF10A(7), TNFRSF10B(5), TNFRSF25(6), TNFSF10(9), TNFSF12(2), TRAF2(2) 14242218 131 89 129 80 72 17 9 20 13 0 0.879 1.000 1.000 310 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(5), ICAM1(2), ITGA4(45), ITGAL(27), ITGB1(4), ITGB2(17), SELE(33), SELL(12) 5121911 145 89 139 56 105 5 4 11 18 2 0.0283 1.000 1.000 311 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 26 BCAR1(5), CALM1(1), CALM2(1), CRKL(2), GNAQ(6), GRB2(2), HRAS(3), JUN(1), MAP2K2(5), MAP2K3(9), MAP2K4(4), MAP3K1(4), MAPK1(4), MAPK14(5), MAPK3(3), MAPK8(2), PAK1(4), PLCG1(9), PRKCA(9), PTK2B(12), RAF1(11), SHC1(2), SOS1(10), SRC(2), SYT1(23) 11620131 139 89 131 86 80 15 8 21 15 0 0.933 1.000 1.000 312 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 27 AKT1(4), AKT2(8), AKT3(3), BCL2(3), GRB2(2), GSK3A(1), GSK3B(3), IL4R(18), IRS1(5), IRS2(3), JAK1(7), JAK3(11), MAP4K1(12), MAPK1(4), MAPK3(3), PDK1(2), PIK3CA(10), PIK3CD(8), PIK3R1(3), PPP1R13B(9), RAF1(11), SHC1(2), SOCS1(1), SOS1(10), SOS2(13), STAT6(9) 15586079 165 89 163 82 91 24 6 26 17 1 0.481 1.000 1.000 313 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(11), ALDH4A1(6), ALDH5A1(10), CAD(18), CPS1(29), EPRS(13), GAD1(14), GAD2(9), GCLC(5), GCLM(2), GFPT1(6), GLS(2), GLS2(3), GLUD1(2), GLUL(1), GMPS(6), GOT1(6), GOT2(6), GPT(4), GPT2(2), GSS(9), NADSYN1(4), QARS(6) 14165629 174 88 167 91 100 19 10 26 18 1 0.485 1.000 1.000 314 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(3), ACAD9(2), ADH1A(17), ADH1B(30), ADH4(12), ADH5(3), ADH6(14), ADH7(16), ADHFE1(6), DHRS1(3), DHRS2(8), DHRS3(5), DHRS7(1), DHRSX(6), ESCO1(2), ESCO2(4), NAT6(5), PNPLA3(3), SH3GLB1(2) 10680233 142 88 125 59 105 9 9 12 7 0 0.103 1.000 1.000 315 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(4), ADCY1(34), CAP1(1), CDC25C(5), GNAI1(2), GNAS(33), GNB1(1), HRAS(3), MAPK1(4), MAPK3(3), MYT1(21), PIN1(1), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), RPS6KA1(9), SRC(2) 8761289 150 88 144 95 101 16 7 13 13 0 0.706 1.000 1.000 316 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(4), GALNT10(7), GALNT2(7), GALNT3(4), GALNT4(5), GALNT6(16), GALNT7(4), GALNT8(28), GALNT9(7), GCNT1(6), ST3GAL1(8), ST3GAL2(1), ST3GAL4(1), WBSCR17(46) 6180311 144 88 133 65 103 9 4 13 15 0 0.0767 1.000 1.000 317 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 25 CSNK2A1(2), ELK1(3), FOS(2), GRB2(2), HRAS(3), JAK1(7), JUN(1), MAP2K4(4), MAP3K1(4), MAPK3(3), MAPK8(2), PDGFA(1), PDGFRA(32), PIK3CA(10), PIK3R1(3), PLCG1(9), PRKCA(9), RAF1(11), RASA1(5), SHC1(2), SOS1(10), SRF(3), STAT1(5), STAT3(11), STAT5A(3) 14537831 147 88 144 73 79 16 7 30 14 1 0.705 1.000 1.000 318 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 14 AKT1(4), BCL2(3), EGFR(25), IGF1R(15), MYC(5), POLR2A(13), PPP2CA(1), PRKCA(9), RB1(10), TEP1(36), TERF1(2), TERT(9), TNKS(10), XRCC5(2) 11652428 144 88 140 87 84 15 9 16 18 2 0.765 1.000 1.000 319 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CALM1(1), CALM2(1), CHUK(2), EGR2(5), EGR3(4), GNAQ(6), MAP3K1(4), MYC(5), NFATC1(17), NFATC2(12), NFKB1(6), NFKBIA(2), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), RELA(4), SYT1(23), VIP(5), VIPR2(7) 11897942 151 88 144 93 97 11 8 17 18 0 0.888 1.000 1.000 320 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(4), EPHA4(22), EPHB1(31), FYN(8), ITGA1(23), ITGB1(4), L1CAM(11), LYN(11), RAP1B(1), SELP(38) 6728695 153 87 141 77 108 7 4 17 16 1 0.297 1.000 1.000 321 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 20 ATM(16), ATR(22), BRCA1(16), BRCA2(21), CHEK1(2), CHEK2(2), FANCA(8), FANCC(2), FANCD2(14), FANCE(4), FANCG(7), HUS1(2), MRE11A(5), RAD1(3), RAD17(6), RAD50(6), RAD9A(6), TREX1(1) 18449843 143 86 140 74 93 7 5 17 21 0 0.906 1.000 1.000 322 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(10), CSF1R(13), EGF(22), EGFR(25), GRB2(2), MET(23), PDGFRA(32), PRKCA(9), SH3GLB1(2), SH3GLB2(1), SH3KBP1(6), SRC(2) 8308320 147 86 145 90 96 9 5 18 19 0 0.885 1.000 1.000 323 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(5), FUCA1(3), GLB1(10), HEXA(5), HEXB(4), LCT(54), MAN2B1(9), MAN2B2(10), MAN2C1(4), MANBA(7), NEU1(6), NEU2(19), NEU3(4), NEU4(16) 8660488 156 86 154 85 111 16 2 14 12 1 0.314 1.000 1.000 324 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1(12), CSF1R(13), DDX20(11), E2F1(6), E2F4(3), ETS1(4), ETS2(8), ETV3(3), FOS(2), HDAC2(2), HDAC5(6), HRAS(3), JUN(1), NCOR2(28), RBL1(14), RBL2(6), SIN3A(11), SIN3B(8) 11072204 141 85 140 81 92 7 3 27 12 0 0.635 1.000 1.000 325 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT1(1), AGPAT2(3), AGPAT3(5), AGPAT4(6), AGPAT6(3), AGPS(5), CHPT1(1), ENPP2(1), ENPP6(14), PAFAH1B1(6), PAFAH1B2(2), PAFAH1B3(1), PAFAH2(2), PLA2G12B(3), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(19), PLA2G4A(16), PLA2G5(2), PLA2G6(13), PLD1(14), PLD2(8), PPAP2B(11), PPAP2C(8) 9935487 163 85 157 86 102 13 5 22 19 2 0.355 1.000 1.000 326 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(3), POLA2(9), POLB(1), POLD1(7), POLD2(2), POLD3(7), POLE(16), POLE2(2), POLG(8), POLG2(7), POLH(4), POLI(2), POLK(7), POLL(10), POLM(2), POLQ(26), PRIM1(3), PRIM2(6), REV1(3), REV3L(18) 17244921 143 85 142 70 78 10 11 26 18 0 0.730 1.000 1.000 327 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(39), ABCB11(49), ABCB4(21), ABCC1(15), ABCC3(30), GSTP1(3) 6071115 157 85 145 75 104 17 5 12 18 1 0.00267 1.000 1.000 328 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(11), AGT(8), AGTR2(10), EDN1(9), EDNRA(11), EDNRB(7), EGF(22), EGFR(25), FOS(2), HRAS(3), JUN(1), MYC(5), NFKB1(6), PLCG1(9), PRKCA(9), RELA(4) 8756081 142 84 139 77 97 10 8 12 14 1 0.357 1.000 1.000 329 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CDK5(6), CDK5R1(1), CSNK1D(3), DRD1(9), DRD2(16), GRM1(13), PLCB1(58), PPP1CA(3), PPP1R1B(2), PPP2CA(1), PPP3CA(5), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5) 6801342 144 84 135 94 106 4 6 13 14 1 0.686 1.000 1.000 330 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 22 ABL1(15), ATM(16), ATR(22), CCNA1(16), CCND1(2), CCNE1(4), CDC25A(8), CDK2(1), CDK6(2), CDKN1A(3), CDKN1B(1), DHFR(1), E2F1(6), GSK3B(3), HDAC1(2), RB1(10), SKP2(2), TFDP1(2), TGFB1(2), TGFB2(3), TGFB3(3) 11971847 124 84 123 60 71 8 10 15 18 2 0.565 1.000 1.000 331 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CALM1(1), CALM2(1), CAMK1(5), CAMK1G(12), CAMK2A(6), CAMK2B(6), CAMK2D(6), CAMK2G(5), CAMK4(17), ESRRA(3), HDAC5(6), MEF2A(3), MEF2B(2), MEF2C(3), MEF2D(6), PPARA(8), PPP3CA(5), PPP3CB(4), PPP3CC(2), SLC2A4(8), SYT1(23) 8558172 132 84 125 80 93 8 5 12 14 0 0.529 1.000 1.000 332 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 14 CUZD1(20), FOS(2), HRAS(3), JUN(1), MAPK1(4), MAPK3(3), MYC(5), NFKB1(6), NFKBIA(2), PLCB1(58), PRKCA(9), RAF1(11), RELA(4), TNF(1) 6311573 129 83 117 56 89 10 7 12 11 0 0.0398 1.000 1.000 333 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(34), GNAS(33), GNB1(1), PPP2CA(1), PRKAA1(1), PRKAA2(32), PRKAB1(2), PRKAB2(2), PRKACB(4), PRKACG(10), PRKAG1(3), PRKAG2(8), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5) 6526432 144 83 137 66 97 14 8 9 16 0 0.172 1.000 1.000 334 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOA(1), ALDOB(14), ALDOC(4), DERA(2), FBP1(3), FBP2(2), G6PD(4), GPI(3), H6PD(7), PFKL(3), PFKP(2), PGD(9), PGLS(3), PGM1(6), PGM3(1), PRPS1(3), PRPS1L1(13), PRPS2(3), RBKS(4), TALDO1(3), TKT(6), TKTL1(3), TKTL2(28) 10337668 127 83 119 91 82 11 5 12 17 0 0.732 1.000 1.000 335 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 35 ANPEP(25), G6PD(4), GCLC(5), GCLM(2), GGT1(8), GPX3(2), GPX5(19), GPX6(19), GSR(2), GSS(9), GSTA1(7), GSTA2(3), GSTA3(1), GSTA4(1), GSTA5(3), GSTK1(4), GSTM1(2), GSTM2(2), GSTM3(4), GSTM4(2), GSTM5(6), GSTO2(1), GSTP1(3), GSTT1(1), GSTZ1(1), IDH2(2), MGST1(2), MGST2(2), MGST3(2), OPLAH(13), TXNDC12(1) 8975346 158 83 148 88 103 10 7 23 15 0 0.125 1.000 1.000 336 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(4), CHIA(10), CHIT1(12), CMAS(2), CTBS(6), CYB5R1(1), CYB5R3(2), GFPT1(6), GFPT2(9), GNE(3), GNPDA1(1), GNPDA2(1), HEXA(5), HEXB(4), HK1(3), HK2(15), HK3(15), LHPP(1), MTMR1(6), MTMR2(3), MTMR6(2), NAGK(1), NANS(1), NPL(2), PGM3(1), RENBP(3), UAP1(2) 12220567 121 83 119 81 74 10 6 19 12 0 0.947 1.000 1.000 337 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(10), GABRA1(20), GABRA2(19), GABRA3(24), GABRA4(15), GABRA5(4), GABRA6(29), GPHN(8), SRC(2), UBQLN1(5) 5015372 136 82 119 76 99 6 5 14 10 2 0.494 1.000 1.000 338 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CHUK(2), CREBBP(24), DUSP1(1), EP300(19), IKBKB(4), IL1B(8), MAP2K3(9), MAP2K6(3), MAP3K7(1), MAPK11(1), MAPK14(5), MYD88(1), NFKB1(6), NFKBIA(2), NR3C1(7), RELA(4), TGFBR2(9), TLR2(15), TNF(1) 12666350 122 82 121 74 73 18 5 15 11 0 0.920 1.000 1.000 339 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 CCNH(1), CDK7(2), ERCC3(6), GTF2A2(1), GTF2B(5), GTF2E1(3), GTF2E2(6), GTF2F2(2), GTF2H1(3), GTF2H4(2), ILK(2), MNAT1(2), POLR1A(13), POLR1B(8), POLR2A(13), POLR2B(14), POLR2C(1), POLR2E(1), POLR2F(2), POLR2H(2), POLR2J(2), POLR3B(15), POLR3D(1), POLR3E(5), POLR3H(1), POLR3K(1), TAF13(1), TAF6(3), TAF7(3), TAF9(2), TBP(4) 14984109 127 82 123 63 75 11 9 21 11 0 0.567 1.000 1.000 340 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 20 AARS(4), ABAT(11), ADSL(6), ADSS(2), AGXT(12), ASL(7), ASNS(9), ASPA(3), CAD(18), CRAT(5), DARS(4), DDO(9), GAD1(14), GAD2(9), GOT1(6), GOT2(6), GPT(4), GPT2(2), NARS(2), PC(14) 10723068 147 81 143 93 98 16 8 12 13 0 0.549 1.000 1.000 341 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 ADRB2(4), AKT1(4), ANXA1(7), CALM1(1), CALM2(1), GNAS(33), GNB1(1), NFKB1(6), NOS3(20), NPPA(5), NR3C1(7), PIK3CA(10), PIK3R1(3), RELA(4), SYT1(23) 7604428 129 81 120 58 88 12 5 18 5 1 0.300 1.000 1.000 342 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(6), DYRK1B(2), GLI2(44), GLI3(19), GSK3B(3), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), SHH(3), SMO(10), SUFU(2) 7088275 116 81 113 78 78 11 5 12 10 0 0.862 1.000 1.000 343 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 ARHGDIB(4), BAG4(3), CASP2(1), CASP3(2), CASP8(9), CRADD(2), DFFA(2), DFFB(2), JUN(1), LMNA(5), LMNB1(2), LMNB2(4), MADD(15), MAP2K4(4), MAP3K1(4), MAP3K7(1), MAPK8(2), PAK1(4), PAK2(9), PRKDC(22), RB1(10), RIPK1(3), SPTAN1(10), TNF(1), TNFRSF1A(4), TRAF2(2) 16569459 128 81 127 72 61 10 12 22 19 4 0.849 1.000 1.000 344 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 AMT(1), ASNS(9), ASRGL1(6), CA1(9), CA12(3), CA13(5), CA2(12), CA3(6), CA4(3), CA5A(3), CA5B(1), CA6(4), CA7(2), CA8(6), CA9(8), CPS1(29), CTH(1), GLS(2), GLS2(3), GLUD1(2), GLUD2(4), GLUL(1), HAL(14) 8995302 134 80 129 68 93 9 5 16 11 0 0.383 1.000 1.000 345 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 20 AKT1(4), EIF4A1(4), EIF4A2(3), EIF4B(6), EIF4EBP1(1), EIF4G1(19), EIF4G2(6), EIF4G3(19), MKNK1(6), PDK2(4), PDPK1(5), PIK3CA(10), PIK3R1(3), PPP2CA(1), RPS6(1), RPS6KB1(4), TSC1(9), TSC2(14) 11458530 119 80 115 52 64 14 7 15 17 2 0.357 1.000 1.000 346 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(36), AGT(8), AGTR1(10), AGTR2(10), BDKRB2(10), KNG1(14), NOS3(20), REN(12) 4227401 120 79 115 72 78 8 6 10 16 2 0.150 1.000 1.000 347 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(2), ALDOA(1), ALDOB(14), ALDOC(4), FBP1(3), FBP2(2), FPGT(3), GCK(16), GMDS(5), GMPPA(1), GMPPB(4), HK1(3), HK2(15), HK3(15), KHK(2), MPI(1), PFKFB1(4), PFKFB3(4), PFKFB4(7), PFKP(2), PMM1(4), PMM2(3), SORD(2), TPI1(1) 10151370 118 79 113 89 79 12 6 9 12 0 0.742 1.000 1.000 348 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(13), BCAT2(1), IARS(10), IARS2(18), ILVBL(5), LARS(13), LARS2(5), PDHA1(4), PDHA2(20), PDHB(1), VARS(16), VARS2(7) 8037888 113 79 104 54 75 12 3 11 12 0 0.362 1.000 1.000 349 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(2), GPLD1(27), PGAP1(9), PIGA(2), PIGB(3), PIGC(3), PIGF(2), PIGG(9), PIGH(2), PIGK(7), PIGL(3), PIGM(2), PIGN(3), PIGO(15), PIGQ(9), PIGS(1), PIGT(1), PIGU(7), PIGV(9), PIGW(1), PIGX(2), PIGZ(4) 10175297 123 79 120 57 69 9 7 26 12 0 0.135 1.000 1.000 350 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CCR5(10), CD3D(7), CD3E(2), CD3G(1), CXCR3(4), ETV5(7), IFNG(4), IL12A(4), IL12B(3), IL12RB1(15), IL12RB2(3), IL18(3), IL18R1(21), JAK2(8), JUN(1), MAP2K6(3), MAPK14(5), MAPK8(2), STAT4(26), TYK2(8) 7913073 137 79 132 63 96 8 4 12 17 0 0.192 1.000 1.000 351 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 18 B2M(5), HLA-A(4), IL18(3), ITGB1(4), KLRC1(4), KLRC2(1), KLRC3(12), KLRC4(6), KLRD1(7), LAT(3), MAPK3(3), PAK1(4), PIK3CA(10), PIK3R1(3), PTK2B(12), PTPN6(5), SYK(15), VAV1(19) 7396024 120 79 114 83 83 5 3 10 17 2 0.979 1.000 1.000 352 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(10), AKR1D1(21), CYP11A1(14), CYP11B1(17), CYP11B2(12), CYP17A1(7), CYP21A2(13), HSD11B1(14), HSD11B2(2), HSD3B1(15), HSD3B2(14) 4123781 139 78 128 66 95 16 5 9 13 1 0.00121 1.000 1.000 353 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(10), AKR1D1(21), CYP11A1(14), CYP11B1(17), CYP11B2(12), CYP17A1(7), CYP21A2(13), HSD11B1(14), HSD11B2(2), HSD3B1(15), HSD3B2(14) 4123781 139 78 128 66 95 16 5 9 13 1 0.00121 1.000 1.000 354 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(29), BST1(2), CD38(6), ENPP1(13), ENPP3(14), NADK(4), NADSYN1(4), NMNAT1(1), NMNAT2(5), NMNAT3(11), NNMT(11), NNT(4), NT5C1A(6), NT5C1B(24), NT5C2(3), NT5E(6), NT5M(2), NUDT12(5), QPRT(6) 9184446 156 78 149 71 99 11 6 18 22 0 0.156 1.000 1.000 355 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG12(2), ATG3(1), ATG5(2), ATG7(11), BECN1(3), IFNA1(1), IFNA10(2), IFNA13(1), IFNA14(8), IFNA16(11), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA5(4), IFNA6(3), IFNA7(6), IFNA8(3), IFNG(4), PIK3C3(3), PIK3R4(6), PRKAA1(1), PRKAA2(32), ULK1(11), ULK2(7), ULK3(1) 8906155 134 78 128 72 93 8 6 15 12 0 0.445 1.000 1.000 356 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(5), CS(2), DLAT(4), DLD(3), DLST(1), FH(3), IDH2(2), IDH3A(3), IDH3B(2), IDH3G(2), MDH1(3), MDH2(4), OGDH(9), PC(14), PDHA1(4), PDHA2(20), PDHB(1), PDHX(2), PDK1(2), PDK2(4), PDK3(6), PDK4(8), PDP2(5), SDHA(4), SDHC(3), SDHD(1), SUCLG1(4), SUCLG2(3) 12129700 124 78 121 65 78 6 8 15 17 0 0.497 1.000 1.000 357 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(5), FUCA1(3), GLB1(10), HEXA(5), HEXB(4), LCT(54), MAN2C1(4), MANBA(7), NEU1(6), NEU2(19), NEU3(4), NEU4(16) 7028228 137 78 135 73 98 13 1 13 11 1 0.403 1.000 1.000 358 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 21 CSNK2A1(2), ELK1(3), FOS(2), GRB2(2), HRAS(3), IL2(4), IL2RA(7), IL2RB(12), IL2RG(3), JAK1(7), JAK3(11), JUN(1), LCK(15), MAPK3(3), MAPK8(2), RAF1(11), SHC1(2), SOS1(10), STAT5A(3), STAT5B(5), SYK(15) 9499189 123 77 120 70 73 13 6 19 12 0 0.676 1.000 1.000 359 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(3), ATP6V0C(1), CAT(8), EPX(9), LPO(20), MPO(12), PRDX1(3), PRDX2(3), PRDX6(4), SHMT1(2), SHMT2(3), TPO(47) 5044091 115 77 111 74 85 10 1 7 12 0 0.444 1.000 1.000 360 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 AKT1(4), PIK3CA(10), PIK3R1(3), PLCB1(58), PLCG1(9), PRKCA(9), VAV1(19) 5486267 112 77 103 59 85 4 2 9 10 2 0.423 1.000 1.000 361 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 27 ATF1(5), CREB5(9), DUSP4(3), DUSP6(2), DUSP9(3), EEF2K(6), GRB2(2), MAP2K2(5), MAPK1(4), MAPK3(3), MKNK1(6), MKNK2(4), MOS(6), NFKB1(6), RAP1A(1), RPS6KA1(9), RPS6KA2(6), RPS6KA3(2), SHC1(2), SOS1(10), SOS2(13), TRAF3(5) 11567996 112 77 110 77 74 11 3 13 11 0 0.984 1.000 1.000 362 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 CALM1(1), CALM2(1), CDKN1A(3), GNAQ(6), MARCKS(1), NFATC1(17), NFATC2(12), NFATC3(11), NFATC4(18), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKCA(9), SP1(5), SP3(1), SYT1(23) 8931852 128 76 120 56 83 12 7 11 14 1 0.205 1.000 1.000 363 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX12(6), ALOX15(10), ALOX15B(9), ALOX5(14), ALOX5AP(1), DPEP1(4), GGT1(8), LTA4H(5), PLA2G2A(2), PLA2G6(13), PTGDS(3), PTGIS(18), PTGS1(20), PTGS2(13), TBXAS1(16) 6367246 142 76 138 81 93 12 4 15 18 0 0.0847 1.000 1.000 364 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(5), BHMT(8), CBS(7), CTH(1), DNMT1(19), DNMT3A(9), DNMT3B(13), MARS(8), MARS2(4), MAT1A(6), MAT2B(2), MTAP(5), MTFMT(2), MTR(12), SRM(1), TAT(21) 8928478 123 76 121 54 76 11 8 12 15 1 0.0657 1.000 1.000 365 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 21 APC(27), AXIN1(10), BTRC(4), CCND1(2), CREBBP(24), CSNK1A1(5), CSNK1D(3), CSNK2A1(2), DVL1(1), FZD1(5), GSK3B(3), HDAC1(2), MAP3K7(1), MYC(5), NLK(5), PPARD(3), PPP2CA(1), TLE1(4), WIF1(7), WNT1(2) 11760686 116 76 114 73 62 9 8 17 20 0 0.985 1.000 1.000 366 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(9), CYP2A13(13), CYP2A6(11), CYP2A7(9), NAT1(2), NAT2(10), XDH(61) 3426350 115 75 106 79 90 5 6 3 11 0 0.199 1.000 1.000 367 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 C9orf47(3), CNR1(12), CNR2(6), DNMT1(19), MTNR1A(10), MTNR1B(8), PTAFR(2), PTGDR(12), PTGER2(7), PTGER4(3), PTGFR(21), PTGIR(5), TBXA2R(4) 4758781 112 75 107 88 77 16 4 8 7 0 0.469 1.000 1.000 368 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(4), CARS(9), DARS(4), EPRS(13), FARS2(6), GARS(6), HARS(8), IARS(10), KARS(4), LARS(13), LARS2(5), MARS(8), MARS2(4), NARS(2), QARS(6), RARS(7), SARS(5), TARS(5), WARS(5), WARS2(4), YARS(3) 13730362 131 74 125 60 77 13 6 16 17 2 0.256 1.000 1.000 369 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ADAM17(1), ERBB4(59), NRG2(9), NRG3(24), PRKCA(9), PSEN1(3) 3808560 105 74 94 39 76 5 3 6 15 0 0.0327 1.000 1.000 370 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 21 AKT1(4), BCL2(3), BCR(14), CRKL(2), FOS(2), GRB2(2), HRAS(3), JAK2(8), JUN(1), MAP2K4(4), MAP3K1(4), MAPK3(3), MAPK8(2), MYC(5), PIK3CA(10), PIK3R1(3), RAF1(11), SOS1(10), STAT1(5), STAT5A(3), STAT5B(5) 11600861 104 74 102 56 52 14 8 16 13 1 0.813 1.000 1.000 371 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 29 ANPEP(25), G6PD(4), GCLC(5), GCLM(2), GGT1(8), GPX3(2), GPX5(19), GSS(9), GSTA1(7), GSTA2(3), GSTA3(1), GSTA4(1), GSTM1(2), GSTM2(2), GSTM3(4), GSTM4(2), GSTM5(6), GSTO2(1), GSTP1(3), GSTT1(1), GSTZ1(1), IDH2(2), MGST1(2), MGST2(2), MGST3(2), PGD(9) 7334581 125 74 118 63 77 8 7 20 13 0 0.0780 1.000 1.000 372 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(2), B4GALNT1(5), GLB1(10), HEXA(5), HEXB(4), LCT(54), SLC33A1(6), ST3GAL1(8), ST3GAL2(1), ST3GAL5(3), ST6GALNAC3(7), ST6GALNAC4(4), ST6GALNAC5(10), ST6GALNAC6(2), ST8SIA1(1), ST8SIA5(12) 7030462 134 74 132 82 90 12 1 19 12 0 0.600 1.000 1.000 373 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(23), CPT1A(14), LEP(4), LEPR(31), PRKAA1(1), PRKAA2(32), PRKAB1(2), PRKAB2(2), PRKAG1(3), PRKAG2(8) 6219439 120 74 112 58 82 5 3 11 19 0 0.505 1.000 1.000 374 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(17), CALM1(1), CALM2(1), CAPN2(6), CAPNS1(2), CAPNS2(1), EP300(19), HDAC1(2), HDAC2(2), MEF2D(6), NFATC1(17), NFATC2(12), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKCA(9), SYT1(23) 10461393 129 74 122 59 84 7 9 13 16 0 0.265 1.000 1.000 375 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(20), AP2A1(2), AP2M1(3), BIN1(5), CALM1(1), CALM2(1), DNM1(10), EPN1(6), EPS15(4), NME1(1), PICALM(2), PPP3CA(5), PPP3CB(4), PPP3CC(2), SYNJ1(23), SYNJ2(22), SYT1(23) 9128501 134 74 128 63 91 9 5 16 13 0 0.260 1.000 1.000 376 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 CHUK(2), IKBKB(4), IL1A(5), IL1R1(12), IRAK1(5), MAP3K1(4), MAP3K7(1), MYD88(1), NFKB1(6), NFKBIA(2), RELA(4), RIPK1(3), TLR4(42), TNF(1), TNFAIP3(2), TNFRSF1A(4), TNFRSF1B(4), TRAF6(4) 10247356 106 74 99 64 74 7 4 10 11 0 0.760 1.000 1.000 377 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(1), ASNS(9), CA1(9), CA12(3), CA2(12), CA3(6), CA4(3), CA5A(3), CA5B(1), CA6(4), CA7(2), CA8(6), CA9(8), CPS1(29), CTH(1), GLS(2), GLS2(3), GLUD1(2), GLUL(1), HAL(14) 8046098 119 74 115 63 83 6 4 16 10 0 0.504 1.000 1.000 378 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(36), CD44(5), CSF1(12), FCGR3A(9), IL1B(8), IL6R(3), SELL(12), SPN(5), TGFB1(2), TGFB2(3), TNF(1), TNFRSF1A(4), TNFRSF1B(4), TNFRSF8(19), TNFSF8(3) 5536832 126 74 119 62 92 7 6 5 16 0 0.0743 1.000 1.000 379 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(29), CD28(2), CD3D(7), CD3E(2), CD3G(1), CD8A(2), ICAM1(2), ITGAL(27), ITGB2(17), PTPRC(36), THY1(1) 4542831 126 74 116 54 84 8 4 7 21 2 0.00854 1.000 1.000 380 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(29), CD28(2), CD3D(7), CD3E(2), CD3G(1), CD4(9), ICAM1(2), ITGAL(27), ITGB2(17), PTPRC(36), THY1(1) 4762451 133 74 122 59 88 8 4 8 23 2 0.0105 1.000 1.000 381 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(34), FHL5(13), FSHB(9), FSHR(21), GNAS(33), XPO1(3) 4054852 113 73 104 51 77 12 6 8 10 0 0.192 1.000 1.000 382 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(20), GABRA2(19), GABRA3(24), GABRA4(15), GABRA5(4), GABRA6(29), PRKCE(7) 3305458 118 73 102 61 86 6 3 13 8 2 0.275 1.000 1.000 383 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(3), CAT(8), EPX(9), LPO(20), MPO(12), MTHFR(3), PRDX6(4), SHMT1(2), SHMT2(3), TPO(47) 4979106 111 73 107 73 84 9 1 7 10 0 0.483 1.000 1.000 384 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(9), LPO(20), MPO(12), PRDX1(3), PRDX2(3), PRDX6(4), TPO(47), TYR(11) 4120139 109 73 105 68 79 11 1 5 13 0 0.484 1.000 1.000 385 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 15 ACTA1(4), ACTN1(8), ACTN2(21), CAPN1(5), CAPNS1(2), CAPNS2(1), ITGA1(23), ITGB1(4), ITGB3(16), PTK2(7), PXN(2), SPTAN1(10), SRC(2), TLN1(12) 11836369 117 73 115 76 75 11 5 10 15 1 0.525 1.000 1.000 386 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(5), ICAM1(2), ITGAL(27), ITGAM(25), ITGB2(17), SELE(33), SELL(12) 4384333 121 72 120 60 87 6 3 6 17 2 0.0738 1.000 1.000 387 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOA(1), ALDOB(14), ALDOC(4), FBP1(3), FBP2(2), G6PD(4), GPI(3), H6PD(7), PFKP(2), PGD(9), PGLS(3), PGM1(6), PGM3(1), PRPS1(3), PRPS1L1(13), PRPS2(3), RBKS(4), TAL1(9), TALDO1(3), TKT(6) 8709126 100 72 96 73 65 7 4 10 14 0 0.767 1.000 1.000 388 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(6), GTF2A1(2), GTF2B(5), GTF2E1(3), GTF2F1(5), HDAC3(5), NCOA1(9), NCOA2(13), NCOA3(19), NCOR2(28), POLR2A(13), RARA(4), RXRA(4), TBP(4) 10591405 120 72 117 55 93 4 5 10 8 0 0.218 1.000 1.000 389 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(16), APOA1(1), APOA4(9), APOC1(3), APOC2(1), APOC3(2), APOE(1), CETP(6), CYP7A1(8), DGAT1(1), HMGCR(4), LDLR(17), LIPC(10), LPL(6), LRP1(47), SCARB1(5), SOAT1(3) 11782522 140 72 137 87 80 20 8 16 14 2 0.565 1.000 1.000 390 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 12 APC(27), CDH1(6), CREBBP(24), EP300(19), MAP3K7(1), MAPK3(3), SKIL(3), TGFB1(2), TGFB2(3), TGFB3(3), TGFBR2(9) 10648246 100 72 100 53 51 14 7 15 13 0 0.934 1.000 1.000 391 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 18 ABL1(15), ATM(16), BRCA1(16), CDKN1A(3), CHEK1(2), CHEK2(2), JUN(1), MAPK8(2), MDM2(4), MRE11A(5), NFKB1(6), NFKBIA(2), RAD50(6), RBBP8(5), RELA(4), TP73(6) 12304033 95 71 94 48 47 12 3 19 14 0 0.909 1.000 1.000 392 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOA(1), ALDOB(14), ALDOC(4), FBP1(3), FBP2(2), GOT1(6), GOT2(6), GPT(4), GPT2(2), MDH1(3), MDH2(4), ME1(22), ME2(2), ME3(8), PGK1(3), PKLR(14), TKT(6), TPI1(1) 7718937 105 71 102 60 74 11 4 6 9 1 0.206 1.000 1.000 393 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD28(2), CD3D(7), CD3E(2), CD3G(1), CD80(4), CD86(25), CTLA4(2), GRB2(2), HLA-DRA(13), HLA-DRB1(5), ICOS(3), IL2(4), ITK(25), LCK(15), PIK3CA(10), PIK3R1(3), PTPN11(10) 5454390 133 71 126 48 88 8 2 18 15 2 0.0677 1.000 1.000 394 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 13 AKT1(4), CAT(8), GH1(5), GHR(43), HRAS(3), IGF1(11), IGF1R(15), PIK3CA(10), PIK3R1(3), SHC1(2) 5668311 104 71 95 45 71 11 2 13 6 1 0.173 1.000 1.000 395 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CCR5(10), CD2(29), CD3D(7), CD3E(2), CD3G(1), CD4(9), CXCR3(4), IFNG(4), IL12A(4), IL12B(3), IL12RB1(15), IL12RB2(3), JAK2(8), STAT4(26), TYK2(8) 6208723 133 71 123 60 88 10 4 10 21 0 0.0588 1.000 1.000 396 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(10), PARK2(11), SNCA(2), SNCAIP(61), UBE2E2(4), UBE2F(5), UBE2G2(1), UBE2L3(1), UBE2L6(2) 2748962 97 71 88 40 73 10 3 5 6 0 0.0981 1.000 1.000 397 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 21 CSNK2A1(2), FOS(2), GRB2(2), HRAS(3), JAK2(8), JUN(1), MAPK3(3), MPL(9), PIK3CA(10), PIK3R1(3), PLCG1(9), PRKCA(9), RAF1(11), RASA1(5), SHC1(2), SOS1(10), STAT1(5), STAT3(11), STAT5A(3), STAT5B(5), THPO(10) 12415943 123 71 120 67 67 12 8 24 11 1 0.916 1.000 1.000 398 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(5), CARM1(7), CBS(7), CTH(1), GGT1(8), HEMK1(4), LCMT1(4), LCMT2(1), MARS(8), MARS2(4), MAT1A(6), MAT2B(2), METTL2B(5), METTL6(2), PAPSS1(4), PAPSS2(5), PRMT2(2), PRMT3(5), PRMT5(7), PRMT7(4), PRMT8(10), SCLY(3), SEPHS1(2), SEPHS2(2), WBSCR22(2) 10680917 110 70 108 61 65 13 5 15 12 0 0.427 1.000 1.000 399 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS(9), CARS2(4), CDO1(6), CTH(1), GOT1(6), GOT2(6), LDHA(5), LDHAL6A(6), LDHAL6B(6), LDHB(2), LDHC(7), MPST(2), SDS(3), SULT1B1(11), SULT1C2(7), SULT1C4(15), SULT4A1(10) 5361463 106 69 102 33 69 5 11 8 13 0 0.00138 1.000 1.000 400 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 B3GNT1(3), B3GNT2(2), B3GNT3(7), B3GNT4(4), B3GNT5(2), B4GALT1(2), B4GALT2(2), B4GALT3(3), B4GALT4(3), FUT1(4), FUT2(4), FUT3(8), FUT4(3), FUT5(8), FUT6(4), FUT7(2), FUT9(29), GCNT2(1), ST3GAL6(4), ST8SIA1(1) 6824352 96 69 91 54 56 12 7 11 9 1 0.381 1.000 1.000 401 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(16), AOC2(9), AOC3(9), CES1(21), DDHD1(8), ESCO1(2), ESCO2(4), LIPA(5), NAT6(5), PLA1A(10), PNPLA3(3), PPME1(1), PRDX6(4), SH3GLB1(2) 10815802 99 69 95 57 74 4 7 6 8 0 0.792 1.000 1.000 402 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 20 CSNK2A1(2), ELK1(3), FOS(2), GRB2(2), HRAS(3), INSR(23), IRS1(5), JUN(1), MAPK3(3), MAPK8(2), PIK3CA(10), PIK3R1(3), PTPN11(10), RAF1(11), RASA1(5), SHC1(2), SLC2A4(8), SOS1(10), SRF(3) 10585461 108 69 104 59 48 17 6 27 9 1 0.920 1.000 1.000 403 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(7), CREBBP(24), EP300(19), NCOA3(19), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), RARA(4), RXRA(4) 8838285 104 67 104 57 62 8 5 17 12 0 0.860 1.000 1.000 404 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 9 EGF(22), EGFR(25), MAP3K1(4), MAPK14(5), NCOR2(28), RARA(4), RXRA(4), THRA(2), THRB(18) 6988569 112 67 110 61 77 11 3 9 12 0 0.528 1.000 1.000 405 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 14 CSF2RB(24), FOS(2), GRB2(2), HRAS(3), IL3(3), IL3RA(8), JAK2(8), MAPK3(3), PTPN6(5), RAF1(11), SHC1(2), SOS1(10), STAT5A(3), STAT5B(5) 7164756 89 67 87 49 49 7 6 11 16 0 0.663 1.000 1.000 406 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD28(2), CD86(25), HLA-DRA(13), HLA-DRB1(5), IFNG(4), IFNGR1(3), IFNGR2(4), IL12A(4), IL12B(3), IL12RB1(15), IL12RB2(3), IL18(3), IL18R1(21), IL2(4), IL2RA(7), IL4(1), IL4R(18) 5388315 135 67 127 50 100 6 0 10 19 0 0.00674 1.000 1.000 407 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 AKT1(4), CHRNB1(4), CHRNG(3), MUSK(36), PIK3CA(10), PIK3R1(3), PTK2(7), PTK2B(12), RAPSN(1), SRC(2), TERT(9) 6942853 91 66 87 79 59 7 0 15 9 1 0.993 1.000 1.000 408 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 19 CSNK2A1(2), ELK1(3), FOS(2), GRB2(2), HRAS(3), IGF1(11), IGF1R(15), IRS1(5), JUN(1), MAPK3(3), MAPK8(2), PIK3CA(10), PIK3R1(3), PTPN11(10), RAF1(11), RASA1(5), SHC1(2), SOS1(10), SRF(3) 10236951 103 66 97 53 49 19 3 24 7 1 0.850 1.000 1.000 409 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 18 ABCB1(39), AKT1(4), ATM(16), BAX(4), CDKN1A(3), CPB2(1), CSNK1A1(5), CSNK1D(3), HIC1(2), HIF1A(4), HSPA1A(1), IGFBP3(3), MAPK8(2), MDM2(4), NFKBIB(1), NQO1(2) 8512093 94 66 84 45 56 7 3 13 14 1 0.623 1.000 1.000 410 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GSR(2), GSS(9), NFKB1(6), NOX1(13), RELA(4), TNF(1), XDH(61) 4206671 96 65 91 51 71 6 4 7 8 0 0.157 1.000 1.000 411 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(9), GBA(7), LPO(20), MPO(12), PRDX6(4), TPO(47) 3577255 99 65 95 67 75 9 1 5 9 0 0.564 1.000 1.000 412 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 18 AKT1(4), EIF2B5(3), EIF2S1(1), EIF2S3(2), EIF4EBP1(1), GSK3B(3), IGF1(11), IGF1R(15), INPPL1(16), PDK2(4), PDPK1(5), PIK3CA(10), PIK3R1(3), PPP2CA(1), RPS6(1), RPS6KB1(4) 8036600 84 65 78 46 50 11 6 9 7 1 0.694 1.000 1.000 413 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 20 CSNK2A1(2), ELK1(3), FOS(2), GRB2(2), HRAS(3), IL6(2), IL6R(3), IL6ST(11), JAK1(7), JAK2(8), JAK3(11), JUN(1), MAPK3(3), PTPN11(10), RAF1(11), SHC1(2), SOS1(10), SRF(3), STAT3(11) 9819721 105 65 103 62 45 16 5 28 11 0 0.968 1.000 1.000 414 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 20 AKT1(4), CCND1(2), CCNE1(4), CDK2(1), CDK6(2), CDKN1A(3), CDKN1B(1), E2F1(6), HRAS(3), MAPK1(4), MAPK3(3), NFKB1(6), NFKBIA(2), PAK1(4), PIK3CA(10), PIK3R1(3), RAF1(11), RB1(10), RELA(4), TFDP1(2) 8140669 85 65 83 49 38 10 7 13 14 3 0.844 1.000 1.000 415 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(4), ALG5(3), B4GALT1(2), B4GALT2(2), B4GALT3(3), B4GALT5(3), DDOST(2), DPAGT1(2), DPM1(1), FUT8(8), MAN1A1(19), MAN1B1(4), MGAT1(3), MGAT2(3), MGAT3(12), MGAT4A(8), MGAT4B(1), MGAT5(6), RPN2(4), ST6GAL1(8) 8528020 98 64 95 63 62 11 3 11 11 0 0.716 1.000 1.000 416 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3D(7), CD3E(2), CD3G(1), CD4(9), FYN(8), HLA-DRA(13), HLA-DRB1(5), LCK(15), PTPRC(36), ZAP70(8) 3783076 104 64 98 40 69 8 3 9 14 1 0.0197 1.000 1.000 417 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(37), MAP2(21), PPP1CA(3), PPP2CA(1), PRKACB(4), PRKACG(10), PRKAG1(3), PRKAR2A(1), PRKAR2B(5), PRKCE(7) 7722806 92 63 91 52 50 10 7 11 13 1 0.918 1.000 1.000 418 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM1(1), CALM2(1), CAMK1(5), CAMK1G(12), CAMK2A(6), CAMK2B(6), CAMK2D(6), CAMK2G(5), CAMK4(17), CAMKK1(3), CAMKK2(9), SYT1(23) 4947143 94 63 88 70 64 8 3 9 10 0 0.868 1.000 1.000 419 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 19 ACO1(8), ACO2(5), CS(2), DLD(3), DLST(1), FH(3), IDH2(2), IDH3A(3), IDH3B(2), IDH3G(2), MDH1(3), MDH2(4), PC(14), PCK1(25), SDHA(4), SUCLG1(4), SUCLG2(3) 8473213 88 63 85 57 58 2 6 10 12 0 0.800 1.000 1.000 420 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(5), BHMT(8), CBS(7), CTH(1), DNMT1(19), DNMT3A(9), DNMT3B(13), MARS(8), MARS2(4), MAT1A(6), MAT2B(2), MTR(12) 7512788 94 63 93 38 56 9 7 10 11 1 0.0419 1.000 1.000 421 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 ATF1(5), CASP2(1), CHUK(2), CRADD(2), IKBKB(4), JUN(1), LTA(5), MAP2K3(9), MAP2K4(4), MAP2K6(3), MAP3K1(4), MAP4K2(7), MAPK14(5), MAPK8(2), NFKB1(6), NFKBIA(2), RELA(4), RIPK1(3), TNF(1), TNFRSF1A(4), TRAF2(2) 10155954 76 63 76 46 45 10 3 8 9 1 0.721 1.000 1.000 422 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 16 DNAJA3(5), HSPA1A(1), IFNG(4), IFNGR1(3), IFNGR2(4), IKBKB(4), JAK2(8), NFKB1(6), NFKBIA(2), RB1(10), RELA(4), TNF(1), TNFRSF1A(4), TNFRSF1B(4), USH1C(23), WT1(10) 7165911 93 63 88 39 41 9 4 12 25 2 0.263 1.000 1.000 423 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(5), GNAQ(6), GNB1(1), HTR2C(14), PLCB1(58), TUB(10) 3048869 94 63 85 42 71 3 2 9 9 0 0.0574 1.000 1.000 424 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(6), CHUK(2), IFNG(4), IKBKB(4), IL2(4), IL4(1), JUN(1), MAP3K1(4), MAP3K5(23), MAP4K5(5), MAPK14(5), MAPK8(2), NFKB1(6), NFKBIA(2), RELA(4), TNFRSF9(4), TNFSF9(4), TRAF2(2) 8161439 83 62 77 41 45 6 2 12 18 0 0.573 1.000 1.000 425 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 AKT1(4), CASP9(2), CHUK(2), GH1(5), GHR(43), NFKB1(6), NFKBIA(2), PDPK1(5), PIK3CA(10), PIK3R1(3), PPP2CA(1), RELA(4) 5968669 87 62 80 44 58 8 4 10 6 1 0.591 1.000 1.000 426 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 19 AKT1(4), APAF1(6), ATM(16), BAX(4), BCL2(3), CASP3(2), CASP7(4), CASP9(2), CYCS(1), EIF2S1(1), PRKCA(9), PTK2(7), PXN(2), STAT1(5), TLN1(12) 11283078 78 62 75 44 43 10 3 11 11 0 0.801 1.000 1.000 427 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 15 AKT1(4), MAP2K2(5), MAP2K3(9), MAP2K6(3), MAP3K1(4), MAPK1(4), MAPK14(5), MAPK3(3), NFKB1(6), PIK3CA(10), PIK3R1(3), RB1(10), RELA(4), SP1(5) 7916536 75 62 73 45 34 11 4 9 14 3 0.940 1.000 1.000 428 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 16 B3GAT1(8), B3GAT2(3), B3GAT3(4), CHPF(4), CHST11(7), CHST12(7), CHST13(3), CHST14(3), CHST3(2), CHST7(3), CHSY1(9), DSE(20), XYLT1(12), XYLT2(5) 5811712 90 62 90 62 57 13 4 8 8 0 0.545 1.000 1.000 429 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(13), POLR1B(8), POLR1C(1), POLR2A(13), POLR2B(14), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(2), POLR2H(2), POLR2J(2), POLR2L(1), POLR3A(8), POLR3B(15), POLR3G(1), POLR3GL(3), POLR3H(1), POLR3K(1) 10017523 88 62 85 49 50 9 6 17 6 0 0.740 1.000 1.000 430 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(29), CD38(6), ENPP1(13), ENPP3(14), NADSYN1(4), NMNAT1(1), NMNAT2(5), NNMT(11), NNT(4), NT5E(6), NT5M(2), QPRT(6) 6212326 101 62 95 46 61 9 5 12 14 0 0.258 1.000 1.000 431 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(24), EP300(19), LPL(6), NCOA1(9), NCOA2(13), PPARG(12), RXRA(4) 7931311 87 62 84 36 52 11 4 12 8 0 0.395 1.000 1.000 432 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 14 AKT1(4), AKT2(8), AKT3(3), CDKN1A(3), ELK1(3), GRB2(2), HRAS(3), MAP2K2(5), NGFR(8), NTRK1(16), PIK3CA(10), PIK3CD(8), SHC1(2), SOS1(10) 6493871 85 62 83 41 38 17 4 17 9 0 0.520 1.000 1.000 433 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ACY1(2), ALDH18A1(8), ARG1(2), ARG2(2), ASL(7), CKM(3), CKMT1A(1), CKMT2(5), CPS1(29), GAMT(4), GATM(6), GLUD1(2), NAGS(1), OAT(4), ODC1(3), OTC(4), PYCR1(1), SMS(5) 7380470 89 62 86 41 51 9 5 13 11 0 0.217 1.000 1.000 434 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(3), GALNS(5), GLB1(10), GNS(2), GUSB(5), HEXA(5), HEXB(4), IDS(9), IDUA(6), LCT(54), NAGLU(4) 6107486 107 61 105 62 80 8 0 10 9 0 0.515 1.000 1.000 435 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(5), CYSLTR2(4), GPR161(8), GPR171(10), GPR18(5), GPR34(3), GPR39(12), GPR45(8), GPR65(14), GPR68(3), GPR75(6) 4172726 78 61 75 41 53 5 3 8 9 0 0.0139 1.000 1.000 436 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(23), ACACB(23), FASN(25), MCAT(2), OLAH(11), OXSM(2) 6754738 86 61 84 54 52 9 3 8 14 0 0.605 1.000 1.000 437 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP1(4), ACP2(3), ACP5(3), ACP6(12), ACPP(9), ACPT(3), ENPP1(13), ENPP3(14), FLAD1(11), LHPP(1), MTMR1(6), MTMR2(3), MTMR6(2), TYR(11) 6398037 95 61 91 29 62 5 5 7 16 0 0.0150 1.000 1.000 438 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CD4(9), CSF1(12), CSF2(2), CSF3(4), HLA-DRA(13), HLA-DRB1(5), IFNA1(1), IFNB1(6), IFNG(4), IL10(2), IL11(3), IL12A(4), IL12B(3), IL13(2), IL15(3), IL1A(5), IL2(4), IL3(3), IL4(1), IL5(4), IL6(2), IL7(5), LTA(5), PDGFA(1), TGFB1(2), TGFB2(3), TGFB3(3), TNF(1) 5614094 112 61 109 58 73 5 3 11 20 0 0.0288 1.000 1.000 439 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 21 AKT1(4), AP2A1(2), AP2M1(3), BTK(15), EEA1(3), GRASP(3), GSK3A(1), GSK3B(3), LYN(11), PDPK1(5), PFKL(3), PFKP(2), PLCG1(9), PRKCE(7), PRKCZ(3), RAB5A(2), RPS6KB1(4), VAV2(5) 10372921 85 61 83 60 49 9 4 7 16 0 0.794 1.000 1.000 440 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(3), KHK(2), LCT(54), MPI(1), PGM1(6), PYGL(9), PYGM(14), TPI1(1), TREH(2) 5632350 92 60 91 71 66 7 1 11 7 0 0.786 1.000 1.000 441 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(9), ASPH(6), COPS5(3), EDN1(9), EP300(19), EPO(5), HIF1A(4), JUN(1), LDHA(5), NOS3(20), P4HB(3), VHL(4) 7297451 88 60 85 41 55 5 5 10 13 0 0.588 1.000 1.000 442 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(8), ACOX3(13), FADS2(4), PLA2G12B(3), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(19), PLA2G4A(16), PLA2G5(2), PLA2G6(13) 4320806 97 60 97 46 66 7 2 6 15 1 0.0649 1.000 1.000 443 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(6), BIRC2(6), BIRC3(7), CASP10(6), CASP3(2), CASP7(4), CASP8(9), CASP9(2), DFFA(2), DFFB(2), GZMB(3), PRF1(14), SCAP(12), SREBF1(5), SREBF2(10) 7765698 90 60 86 51 52 8 6 14 10 0 0.694 1.000 1.000 444 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(7), F13B(35), HSD17B2(13), HSD17B3(5), HSD17B4(6), HSD17B7(1), HSD3B1(15), HSD3B2(14) 3418004 96 60 90 38 68 6 6 4 12 0 0.0211 1.000 1.000 445 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARFGAP1(5), ARFGAP3(3), ARFGEF2(15), CLTA(1), CLTB(1), COPA(10), GBF1(15), GPLD1(27), KDELR1(1), KDELR3(2) 6983853 80 59 78 46 41 7 3 16 13 0 0.701 1.000 1.000 446 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM1(1), CALM2(1), CCL2(3), CCR5(10), CXCL12(2), CXCR4(3), FOS(2), GNAQ(6), JUN(1), MAPK14(5), MAPK8(2), PLCG1(9), PRKCA(9), PTK2B(12), SYT1(23) 5899387 89 59 83 69 60 7 5 12 5 0 0.927 1.000 1.000 447 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 20 CCNA1(16), CCND1(2), CCND2(7), CCND3(2), CCNE1(4), CCNH(1), CDC25A(8), CDK2(1), CDK6(2), CDK7(2), CDKN1A(3), CDKN1B(1), CDKN2C(1), E2F1(6), RB1(10), RBL1(14), TFDP1(2) 6353530 82 59 82 30 46 4 7 12 11 2 0.0720 1.000 1.000 448 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 MRPL13(3), MRPS7(1), RPL10A(1), RPL10L(8), RPL11(4), RPL12(1), RPL13(1), RPL13A(2), RPL14(1), RPL18(3), RPL18A(2), RPL19(1), RPL21(2), RPL26(1), RPL27(3), RPL27A(1), RPL29(1), RPL3(2), RPL30(1), RPL32(1), RPL35(1), RPL35A(1), RPL36AL(1), RPL38(1), RPL39(1), RPL3L(5), RPL6(1), RPL7(2), RPS11(1), RPS13(1), RPS15A(1), RPS16(1), RPS18(2), RPS2(2), RPS20(2), RPS23(1), RPS24(1), RPS26(1), RPS27(2), RPS29(1), RPS3A(1), RPS5(1), RPS6(1), RPS7(4), RPS8(1), RPSA(1) 9608800 78 59 78 56 39 7 6 15 11 0 0.942 1.000 1.000 449 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP5O(5), ATP6AP1(3), ATP6V0A1(13), ATP6V0A4(23), ATP6V0C(1), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(7), ATP6V1H(5), FDXR(10), SHMT1(2) 6838473 90 59 89 55 52 4 6 13 15 0 0.609 1.000 1.000 450 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 15 AKT1(4), AKT2(8), AKT3(3), GRB2(2), ILK(2), MAPK1(4), MAPK3(3), PDK1(2), PIK3CA(10), PIK3CD(8), PTK2B(12), RBL2(6), SHC1(2), SOS1(10) 8413700 76 59 75 47 39 9 3 19 6 0 0.938 1.000 1.000 451 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(5), ATP6AP1(3), ATP6V0A1(13), ATP6V0A4(23), ATP6V0C(1), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(7), ATP6V1H(5), SHMT1(2) 6426898 80 58 79 51 45 3 6 12 14 0 0.723 1.000 1.000 452 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(1), POLD1(7), POLD2(2), POLE(16), POLG(8), POLL(10), POLQ(26) 7138206 70 58 69 38 39 8 2 13 8 0 0.556 1.000 1.000 453 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(5), ATP6AP1(3), ATP6V0A1(13), ATP6V0A4(23), ATP6V0C(1), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(7), ATP6V1H(5), SHMT1(2) 6426898 80 58 79 51 45 3 6 12 14 0 0.723 1.000 1.000 454 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 A4GALT(7), B3GALNT1(6), B3GALT5(1), FUT1(4), FUT2(4), FUT9(29), GBGT1(3), GLA(2), HEXA(5), HEXB(4), NAGA(5), ST3GAL1(8), ST3GAL2(1), ST8SIA1(1) 4586406 80 58 75 49 47 10 5 13 5 0 0.596 1.000 1.000 455 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 12 CREBBP(24), DAXX(10), HRAS(3), PAX3(3), PML(3), RARA(4), RB1(10), SIRT1(2), SP100(12), TNF(1), TNFRSF1A(4), TNFRSF1B(4) 7686287 80 58 80 37 30 13 7 13 15 2 0.511 1.000 1.000 456 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 CISH(4), IL6(2), IL6R(3), JAK1(7), JAK2(8), JAK3(11), PIAS3(6), PTPRU(23), REG1A(8), SRC(2), STAT3(11) 6479384 85 58 84 54 48 10 3 10 14 0 0.739 1.000 1.000 457 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BAG4(3), BIRC2(6), BIRC3(7), CASP3(2), CASP8(9), CFLAR(4), JUN(1), MAP2K4(4), MAP3K3(8), MAP3K7(1), NFKB1(6), NFKB2(5), NFKBIA(2), NFKBIB(1), NFKBIL1(2), NR2C2(1), RALBP1(3), RIPK1(3), TNF(1), TNFAIP3(2), TNFRSF1A(4), TNFRSF1B(4), TRAF2(2) 11547447 81 58 80 57 46 3 8 13 11 0 0.978 1.000 1.000 458 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(5), ATP6AP1(3), ATP6V0A1(13), ATP6V0A4(23), ATP6V0C(1), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(7), ATP6V1H(5), SHMT1(2) 6426898 80 58 79 51 45 3 6 12 14 0 0.723 1.000 1.000 459 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 13 ABL1(15), E2F1(6), MDM2(4), MYC(5), PIK3CA(10), PIK3R1(3), POLR1A(13), POLR1B(8), POLR1C(1), RB1(10), TBX2(6), TWIST1(1) 7857531 82 57 80 34 47 8 3 11 10 3 0.225 1.000 1.000 460 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 12 ACTN1(8), ACTN2(21), BCAR1(5), CSK(1), CTNNA1(3), CTNNA2(28), PTK2(7), PXN(2), SRC(2), VCL(9) 7366503 86 57 82 61 58 6 4 7 10 1 0.710 1.000 1.000 461 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 AKT1(4), GRB2(2), HRAS(3), MAPK1(4), MAPK3(3), MAPK7(4), MEF2A(3), MEF2B(2), MEF2C(3), MEF2D(6), NTRK1(16), PIK3CA(10), PIK3R1(3), PLCG1(9), RPS6KA1(9), SHC1(2) 8066485 83 57 80 65 49 12 5 9 7 1 0.986 1.000 1.000 462 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(12), CYP11A1(14), CYP11B2(12), CYP17A1(7), HSD11B1(14), HSD11B2(2), HSD3B1(15), HSD3B2(14) 2941950 90 57 85 58 66 9 1 5 9 0 0.0645 1.000 1.000 463 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(40), CYP2C9(41) 862439 81 57 73 58 61 5 2 2 11 0 0.830 1.000 1.000 464 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACAA1(6), ACOX1(8), ACOX3(13), ELOVL2(2), ELOVL5(1), ELOVL6(2), FADS2(4), FASN(25), HADHA(6), HSD17B12(4), PECR(2), SCD(4) 6109332 77 57 77 37 48 7 4 8 10 0 0.0580 1.000 1.000 465 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(6), ALDH3A1(10), ALDH3A2(3), ALDH9A1(3), ECHS1(3), EHHADH(6), HADHA(6), SDS(3) 5173131 76 57 71 35 43 9 4 11 9 0 0.137 1.000 1.000 466 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(5), ACADM(5), ACADS(5), ACADVL(1), ACSL1(8), ACSL3(8), ACSL4(5), CPT1A(14), CPT2(2), EHHADH(6), HADHA(6), PECR(2), SCP2(4), SLC25A20(1) 7229827 72 57 68 35 45 4 3 8 12 0 0.574 1.000 1.000 467 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 19 AKT1(4), CASP9(2), CDC42(2), CHUK(2), ELK1(3), H2AFX(2), HRAS(3), MAPK3(3), NFKB1(6), PIK3CA(10), PIK3R1(3), RAF1(11), RALA(1), RALBP1(3), RALGDS(10), RELA(4), RHOA(2) 7552903 71 57 69 46 37 13 2 15 3 1 0.930 1.000 1.000 468 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(6), ARHGDIB(4), BIRC2(6), BIRC3(7), CASP1(4), CASP10(6), CASP2(1), CASP3(2), CASP4(2), CASP7(4), CASP8(9), CASP9(2), CYCS(1), DFFA(2), DFFB(2), GZMB(3), LMNA(5), LMNB1(2), LMNB2(4), PRF1(14) 8328136 86 56 85 51 46 10 6 14 10 0 0.885 1.000 1.000 469 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 18 CSNK2A1(2), ELK1(3), EPO(5), EPOR(1), FOS(2), GRB2(2), HRAS(3), JAK2(8), JUN(1), MAPK3(3), MAPK8(2), PLCG1(9), PTPN6(5), RAF1(11), SHC1(2), SOS1(10), STAT5A(3), STAT5B(5) 8767714 77 56 76 48 36 8 7 15 11 0 0.925 1.000 1.000 470 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 CARM1(7), DHRS1(3), DHRS2(8), DHRS3(5), DHRS7(1), DHRSX(6), HEMK1(4), LCMT1(4), LCMT2(1), METTL2B(5), METTL6(2), PRMT2(2), PRMT3(5), PRMT5(7), PRMT7(4), PRMT8(10), WBSCR22(2) 6426475 76 56 74 41 45 10 1 13 7 0 0.459 1.000 1.000 471 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(9), IL22(2), IL22RA1(13), IL22RA2(3), JAK1(7), JAK2(8), JAK3(11), SOCS3(1), STAT1(5), STAT3(11), STAT5A(3), STAT5B(5), TYK2(8) 7778061 86 56 86 56 49 7 6 15 9 0 0.842 1.000 1.000 472 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 20 BAX(4), BCL2(3), CASP8(9), CYCS(1), MAP2K4(4), MAP3K1(4), MAPK1(4), MAPK3(3), MAPK8(2), NFKB1(6), NSMAF(6), RAF1(11), RELA(4), RIPK1(3), SMPD1(2), TNFRSF1A(4), TRAF2(2) 8370323 72 55 71 35 39 9 4 11 9 0 0.557 1.000 1.000 473 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(9), IL13(2), IL4(1), IL5(4), MAF(1), MAP2K3(9), MAPK14(5), NFATC1(17), NFATC2(12), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5) 5161279 87 55 83 56 57 8 3 5 14 0 0.633 1.000 1.000 474 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 17 CSNK2A1(2), DPM2(1), ELK1(3), FOS(2), GRB2(2), HRAS(3), JUN(1), KLK2(5), MAPK3(3), MAPK8(2), NGFR(8), PIK3CA(10), PIK3R1(3), PLCG1(9), RAF1(11), SHC1(2), SOS1(10) 7791466 77 55 75 44 37 11 3 18 7 1 0.909 1.000 1.000 475 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 11 ADAM17(1), APC(27), AXIN1(10), BTRC(4), DLL1(3), DVL1(1), FZD1(5), GSK3B(3), NOTCH1(9), PSEN1(3), WNT1(2) 8333704 68 55 68 52 37 8 3 8 12 0 0.994 1.000 1.000 476 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 CISH(4), JAK1(7), JAK2(8), JAK3(11), PIAS1(7), PIAS3(6), PTPRU(23), REG1A(8), SOAT1(3) 5825301 77 55 76 34 47 9 2 6 13 0 0.135 1.000 1.000 477 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 A4GALT(7), FUT1(4), FUT2(4), FUT9(29), GBGT1(3), GLA(2), HEXA(5), HEXB(4), NAGA(5), ST3GAL1(8), ST3GAL2(1), ST3GAL4(1), ST8SIA1(1) 4318655 74 54 69 40 43 10 3 12 6 0 0.343 1.000 1.000 478 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CHUK(2), CREBBP(24), EP300(19), HDAC3(5), IKBKB(4), NFKB1(6), NFKBIA(2), RELA(4), RIPK1(3), TNF(1), TNFRSF1A(4), TNFRSF1B(4), TRAF6(4) 9521393 82 54 82 39 45 10 6 13 8 0 0.483 1.000 1.000 479 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(4), GNAS(33), GNB1(1), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCA(9) 4059172 74 53 70 41 52 8 3 6 5 0 0.726 1.000 1.000 480 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(2), CYB5R3(2), GCK(16), GFPT1(6), GNE(3), GNPDA1(1), GNPDA2(1), HEXA(5), HEXB(4), HK1(3), HK2(15), HK3(15), PGM3(1), RENBP(3), UAP1(2) 7242946 79 53 76 53 51 5 2 12 9 0 0.877 1.000 1.000 481 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(3), EGF(22), EGFR(25), HGS(5), RAB5A(2), TF(16), TFRC(4) 5473784 77 53 77 49 51 5 5 6 10 0 0.896 1.000 1.000 482 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 14 AKT1(4), GRB2(2), HRAS(3), IGF1R(15), IRS1(5), MAPK1(4), MAPK3(3), PIK3CA(10), PIK3R1(3), RAF1(11), SHC1(2), SOS1(10) 7784376 72 53 68 37 37 12 3 13 6 1 0.713 1.000 1.000 483 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 14 APAF1(6), ATM(16), BAX(4), BCL2(3), CCND1(2), CCNE1(4), CDK2(1), CDKN1A(3), E2F1(6), MDM2(4), PCNA(2), RB1(10), TIMP3(5) 7064843 66 53 65 28 26 7 4 12 15 2 0.588 1.000 1.000 484 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 17 ACTA1(4), ACTR2(3), ACTR3(2), ARPC1B(3), ARPC2(1), ARPC3(2), ARPC4(1), NCK1(2), NCKAP1(5), NTRK1(16), PIR(1), PSMA7(1), WASF1(5), WASF2(6), WASF3(14), WASL(4) 6348133 70 52 69 38 42 7 4 9 8 0 0.855 1.000 1.000 485 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(5), CD3D(7), CD3E(2), CD3G(1), GZMB(3), HLA-A(4), ICAM1(2), ITGAL(27), ITGB2(17), PRF1(14) 3717659 82 52 81 38 47 8 3 5 18 1 0.0642 1.000 1.000 486 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(4), APAF1(6), BCL2(3), CASP3(2), CASP9(2), CYCS(1), DAXX(10), FAS(5), FASLG(15), HSPB1(2), HSPB2(1), IL1A(5), MAPKAPK2(5), MAPKAPK3(5), TNF(1) 4856088 67 52 65 39 42 7 2 7 9 0 0.623 1.000 1.000 487 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 10 ATM(16), CDC25A(8), CDC25B(4), CDC25C(5), CDK2(1), CHEK1(2), MYT1(21), RB1(10), WEE1(2) 6870982 69 52 67 30 39 4 3 10 11 2 0.491 1.000 1.000 488 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 13 ACTR2(3), ACTR3(2), ARPC1B(3), ARPC2(1), ARPC3(2), ARPC4(1), CDC42(2), PAK1(4), PDGFRA(32), PIK3CA(10), PIK3R1(3), WASL(4) 5555636 67 51 66 28 43 3 3 11 6 1 0.399 1.000 1.000 489 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(22), EGFR(25), ERBB3(5), NRG1(16), UBE2D1(1) 4414469 69 51 69 45 47 2 3 7 9 1 0.951 1.000 1.000 490 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT1(3), B3GNT2(2), B3GNT7(6), B4GALT1(2), B4GALT2(2), B4GALT3(3), B4GALT4(3), CHST1(11), CHST2(5), CHST4(10), CHST6(4), FUT8(8), ST3GAL1(8), ST3GAL2(1), ST3GAL3(2), ST3GAL4(1) 5319249 71 51 70 51 45 14 3 4 5 0 0.692 1.000 1.000 491 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT2(1), ACOT11(11), ACYP1(1), DHRS1(3), DHRS2(8), DHRS3(5), DHRS7(1), DHRSX(6), ECHS1(3), EHHADH(6), ESCO1(2), ESCO2(4), GCDH(6), HADHA(6), NAT6(5), PNPLA3(3), SH3GLB1(2), YOD1(1) 11127647 74 51 73 46 41 11 6 11 5 0 0.917 1.000 1.000 492 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(16), AMT(1), ATIC(5), DHFR(1), FTCD(3), GART(10), MTFMT(2), MTHFD1(12), MTHFD1L(2), MTHFD2(2), MTHFR(3), MTR(12), SHMT1(2), SHMT2(3), TYMS(2) 8079674 76 51 74 44 50 6 3 8 9 0 0.644 1.000 1.000 493 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(7), CLOCK(4), CRY1(7), CRY2(7), CSNK1D(3), CSNK1E(5), NPAS2(6), NR1D1(1), PER1(8), PER2(12), PER3(12) 7252975 72 51 68 52 48 7 1 6 10 0 0.964 1.000 1.000 494 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCL11(3), CCR3(11), CD4(9), HLA-DRA(13), HLA-DRB1(5), IL1B(8), IL4(1), IL5(4), IL5RA(16), IL6(2) 2279822 72 51 66 38 55 0 1 6 10 0 0.0696 1.000 1.000 495 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 15 AKT1(4), BCAR1(5), CDKN1B(1), GRB2(2), ILK(2), ITGB1(4), MAPK1(4), MAPK3(3), PDK2(4), PDPK1(5), PIK3CA(10), PIK3R1(3), PTK2(7), SHC1(2), SOS1(10) 7844630 66 51 64 39 36 8 3 13 5 1 0.933 1.000 1.000 496 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(24), EP300(19), ESR1(6), MAPK1(4), MAPK3(3), PELP1(12), SRC(2) 6263992 70 50 70 39 42 7 5 11 5 0 0.777 1.000 1.000 497 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 AKT1(4), DPM2(1), GRB2(2), HRAS(3), KLK2(5), NTRK1(16), PIK3CA(10), PIK3R1(3), PLCG1(9), PRKCA(9), SHC1(2), SOS1(10) 6637650 74 50 72 42 42 9 3 11 8 1 0.831 1.000 1.000 498 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(9), ANKRD1(1), ATF3(1), CYR61(2), DUSP14(2), EIF4EBP1(1), HBEGF(1), IFNG(4), IFRD1(2), IL18(3), IL1A(5), IL1R1(12), JUND(1), MYOG(3), NR4A3(10), WDR1(6) 4534195 63 49 58 31 41 5 2 5 10 0 0.494 1.000 1.000 499 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(4), GRB2(2), IL2RG(3), IL4(1), IL4R(18), IRS1(5), JAK1(7), JAK3(11), RPS6KB1(4), SHC1(2), STAT6(9) 6294755 66 49 65 32 37 10 4 8 7 0 0.278 1.000 1.000 500 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(4), ENO2(5), ENO3(4), FARS2(6), GOT1(6), GOT2(6), PAH(12), TAT(21), YARS(3) 3561109 67 49 64 34 44 6 2 7 8 0 0.132 1.000 1.000 501 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(2), MAPK14(5), MAPK8(2), NFKB1(6), RELA(4), TNFRSF13B(11), TNFRSF17(7), TNFSF13B(3), TRAF2(2), TRAF3(5), TRAF5(8), TRAF6(4) 6134800 59 49 58 26 42 6 0 8 3 0 0.250 1.000 1.000 502 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(9), CHAT(20), CHKA(2), PCYT1A(3), PDHA1(4), PDHA2(20), PEMT(2), SLC18A3(2) 2931222 62 48 58 34 43 7 2 3 6 1 0.248 1.000 1.000 503 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(8), ACO2(5), AFMID(1), CS(2), GRHPR(1), HAO1(8), HAO2(15), HYI(2), MDH1(3), MDH2(4), MTHFD1(12), MTHFD1L(2), MTHFD2(2) 5716791 65 48 61 39 35 5 4 7 14 0 0.665 1.000 1.000 504 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(5), CAMK1G(12), HDAC9(45), MEF2A(3), MEF2B(2), MEF2C(3), MEF2D(6), MYOD1(1) 3182933 77 48 67 41 61 5 2 3 6 0 0.363 1.000 1.000 505 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 CHUK(2), DUSP1(1), IKBKAP(7), IKBKB(4), LTA(5), MAP3K1(4), NFKB1(6), NFKBIA(2), RELA(4), RIPK1(3), TNFAIP3(2), TNFRSF1B(4), TRAF1(6), TRAF2(2), TRAF3(5) 9515594 57 48 57 49 36 6 1 6 8 0 0.994 1.000 1.000 506 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 FOS(2), JUN(1), MAPK3(3), OPRK1(23), POLR2A(13), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5) 5485395 69 47 68 67 51 3 4 5 6 0 0.997 1.000 1.000 507 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(8), ACO2(5), CS(2), GRHPR(1), HAO1(8), HAO2(15), HYI(2), MDH1(3), MDH2(4), MTHFD1(12), MTHFD1L(2), MTHFD2(2) 5458276 64 47 60 35 35 5 3 7 14 0 0.514 1.000 1.000 508 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 AKR1B10(10), DHRS1(3), DHRS2(8), DHRS3(5), DHRS7(1), DHRSX(6), HSD3B7(5), PON1(14), PON2(3), PON3(7), RDH11(2), RDH12(2), RDH13(3), RDH14(1) 3856527 70 47 69 36 50 4 2 7 7 0 0.183 1.000 1.000 509 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(29), CD34(4), CD3D(7), CD3E(2), CD3G(1), CD4(9), CD58(1), CD8A(2), CSF3(4), IL3(3), IL6(2), KITLG(10) 2619952 74 47 66 33 52 3 2 8 9 0 0.0671 1.000 1.000 510 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(16), AMT(1), ATIC(5), ATP6V0C(1), DHFR(1), GART(10), MTHFD1(12), MTHFD1L(2), MTHFD2(2), MTHFR(3), MTR(12), SHMT1(2), SHMT2(3), TYMS(2) 7629387 72 47 70 39 47 6 3 8 8 0 0.493 1.000 1.000 511 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(3), IFNB1(6), JAK1(7), PTPRU(23), REG1A(8), STAT1(5), STAT2(6), TYK2(8) 5351023 66 47 65 36 37 8 1 8 12 0 0.333 1.000 1.000 512 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(16), CDC25A(8), CDC25B(4), CDC25C(5), CHEK1(2), MYT1(21), WEE1(2) 5870983 58 46 56 27 38 4 2 8 6 0 0.563 1.000 1.000 513 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(7), CHPT1(1), HEMK1(4), LCMT1(4), LCMT2(1), METTL2B(5), METTL6(2), PCYT1A(3), PCYT1B(9), PRMT2(2), PRMT3(5), PRMT5(7), PRMT7(4), PRMT8(10), WBSCR22(2) 5990805 66 46 64 34 38 8 3 11 6 0 0.467 1.000 1.000 514 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 11 CDK5(6), CDK5R1(1), DPM2(1), EGR1(4), HRAS(3), KLK2(5), MAP2K2(5), MAPK1(4), MAPK3(3), NGFR(8), RAF1(11) 3140623 51 45 49 29 23 8 3 9 8 0 0.474 1.000 1.000 515 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(6), ARHGAP5(13), ARHGDIB(4), CASP1(4), CASP10(6), CASP3(2), CASP8(9), CASP9(2), CYCS(1), GZMB(3), JUN(1), PRF1(14) 5517335 65 45 63 38 41 4 2 13 5 0 0.888 1.000 1.000 516 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(14), CDO1(6), CSAD(6), GAD1(14), GAD2(9), GGT1(8) 2421221 57 45 54 36 36 7 4 5 5 0 0.654 1.000 1.000 517 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 CHST11(7), CHST12(7), CHST13(3), PAPSS1(4), PAPSS2(5), SULT1A1(14), SULT1A2(3), SULT1E1(16), SULT2A1(9), SULT2B1(6), SUOX(4) 3896847 78 45 75 42 57 6 0 6 9 0 0.280 1.000 1.000 518 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(2), BLVRB(1), HMOX1(1), IL10(2), IL10RA(9), IL10RB(7), IL1A(5), IL6(2), JAK1(7), STAT1(5), STAT3(11), STAT5A(3), TNF(1) 5208279 56 45 55 36 30 4 5 8 9 0 0.663 1.000 1.000 519 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(6), ALDH3A1(10), ALDH3A2(3), ALDH9A1(3) 3395939 58 44 54 26 32 6 4 9 7 0 0.128 1.000 1.000 520 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(6), ALDH3A1(10), ALDH3A2(3), ALDH9A1(3) 3395939 58 44 54 26 32 6 4 9 7 0 0.128 1.000 1.000 521 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(12), CS(2), MDH1(3), ME1(22), PC(14), PDHA1(4), SLC25A11(4) 3974326 61 44 59 30 38 6 2 10 4 1 0.204 1.000 1.000 522 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 18 APAF1(6), BAK1(2), BAX(4), BCL2(3), BIK(2), BIRC2(6), BIRC3(7), CASP3(2), CASP7(4), CASP8(9), CASP9(2), CYCS(1), DFFA(2), DFFB(2), DIABLO(2) 5753598 54 44 53 20 26 6 6 6 10 0 0.289 1.000 1.000 523 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 ANP32A(3), CREBBP(24), DFFA(2), DFFB(2), GZMA(13), GZMB(3), HMGB2(2), NME1(1), PRF1(14), SET(3) 4524146 67 44 65 27 36 6 6 11 8 0 0.249 1.000 1.000 524 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNA1(1), IFNB1(6), IFNG(4), IL10(2), IL12A(4), IL12B(3), IL13(2), IL15(3), IL16(12), IL18(3), IL1A(5), IL2(4), IL3(3), IL4(1), IL5(4), IL6(2), IL9(1), LTA(5), TNF(1) 4210761 66 43 64 42 44 3 2 4 13 0 0.401 1.000 1.000 525 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(25), CKM(3), GPT(4), LDHA(5), LDHB(2), LDHC(7), MAPK14(5), NCL(6) 3838812 57 43 54 29 38 7 6 3 3 0 0.365 1.000 1.000 526 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 CISH(4), IFNG(4), IFNGR1(3), JAK1(7), JAK2(8), PLA2G2A(2), PTPRU(23), REG1A(8), STAT1(5) 4868210 64 43 63 28 36 6 1 6 15 0 0.195 1.000 1.000 527 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(9), CDKN1A(3), EPO(5), EPOR(1), GRIN1(8), HIF1A(4), JAK2(8), NFKB1(6), NFKBIA(2), RELA(4) 5348314 50 42 49 27 22 6 5 5 12 0 0.743 1.000 1.000 528 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(2), FOSL2(6), IFNAR1(3), IFNAR2(8), IFNB1(6), MAPK8(2), NFKB1(6), RELA(4), TNFRSF11A(5), TNFSF11(5), TRAF6(4) 4723058 51 42 50 32 35 3 0 8 5 0 0.871 1.000 1.000 529 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(2), LDLR(17), MBTPS1(9), MBTPS2(3), SCAP(12), SREBF1(5), SREBF2(10) 5067953 58 42 55 32 38 3 3 10 4 0 0.469 1.000 1.000 530 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(9), CYP2E1(14), NR1I3(6), PTGS1(20), PTGS2(13) 2299063 62 41 60 37 47 5 0 2 8 0 0.282 1.000 1.000 531 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(16), HK1(3), HK2(15), HK3(15), IMPA1(1), IMPA2(5), ISYNA1(1), PGM1(6), PGM3(1), TGDS(1) 4973149 64 41 62 43 45 5 1 7 6 0 0.633 1.000 1.000 532 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 BNIP1(4), GOSR1(2), GOSR2(2), SNAP25(7), SNAP29(2), STX10(1), STX11(3), STX12(1), STX16(2), STX17(1), STX19(2), STX2(2), STX3(2), STX4(1), STX5(4), STX6(2), TSNARE1(5), VAMP2(1), VAMP3(1), VAMP4(1), VAMP7(6), VAMP8(1), VTI1A(1), VTI1B(1) 7070200 55 41 53 29 31 4 2 9 9 0 0.393 1.000 1.000 533 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(5), CBS(7), CTH(1), GGT1(8), MARS(8), MARS2(4), MAT1A(6), MAT2B(2), PAPSS1(4), PAPSS2(5), SCLY(3), SEPHS1(2) 5313609 55 41 55 31 33 5 4 6 7 0 0.428 1.000 1.000 534 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13(2), IL13RA1(4), IL13RA2(6), IL4R(18), JAK1(7), JAK2(8), TYK2(8) 4464580 53 41 53 26 36 2 2 7 6 0 0.466 1.000 1.000 535 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13(2), IL13RA1(4), IL13RA2(6), IL4R(18), JAK1(7), JAK2(8), TYK2(8) 4464580 53 41 53 26 36 2 2 7 6 0 0.466 1.000 1.000 536 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CASP3(2), CD36(6), FOS(2), FYN(8), JUN(1), MAPK14(5), THBS1(31) 3160320 55 41 54 35 36 2 3 5 9 0 0.868 1.000 1.000 537 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(4), HS3ST1(11), HS3ST2(8), HS3ST3A1(6), HS3ST3B1(1), XYLT1(12), XYLT2(5) 2736347 47 40 47 42 31 5 1 6 4 0 0.885 1.000 1.000 538 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(4), HS3ST1(11), HS3ST2(8), HS3ST3A1(6), HS3ST3B1(1), XYLT1(12), XYLT2(5) 2736347 47 40 47 42 31 5 1 6 4 0 0.885 1.000 1.000 539 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(2), ALDH1B1(11), ALDH2(6), ALDH3A1(10), ALDH3A2(3), ALDH7A1(10), ALDH9A1(3), MIOX(5), UGDH(1) 3615161 51 40 49 27 27 6 6 5 7 0 0.366 1.000 1.000 540 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(3), CYP51A1(1), DHCR24(2), DHCR7(10), FDFT1(1), FDPS(3), GGCX(2), GGPS1(1), HMGCR(4), HSD17B7(1), IDI1(1), IDI2(1), LSS(4), MVD(1), MVK(2), NQO1(2), NSDHL(3), PMVK(2), SQLE(4), TM7SF2(5) 8219769 53 40 53 37 28 11 2 9 3 0 0.884 1.000 1.000 541 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(12), CAPN1(5), CAPNS1(2), CAPNS2(1), CDK5(6), CDK5R1(1), CSNK1A1(5), CSNK1D(3), GSK3B(3), MAPT(10), PPP2CA(1) 3844516 49 40 47 24 30 4 2 6 7 0 0.350 1.000 1.000 542 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD28(2), CD3D(7), CD3E(2), CD3G(1), IFNG(4), IL2(4), IL2RA(7), IL4(1), TGFB1(2), TGFB2(3), TGFB3(3), TGFBR2(9), TGFBR3(9), TOB1(3), TOB2(3) 4494803 60 40 60 31 45 3 1 1 10 0 0.287 1.000 1.000 543 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 CHUK(2), DUSP1(1), IKBKAP(7), IKBKB(4), MAP3K1(4), NFKB1(6), NFKBIA(2), RELA(4), TNFAIP3(2), TRAF3(5), TRAF6(4) 7697587 41 39 41 33 25 6 1 4 5 0 0.979 1.000 1.000 544 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(4), PSMA2(1), PSMA4(4), PSMA5(3), PSMA6(5), PSMA7(1), PSMB1(1), PSMB2(2), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(2), PSMC2(2), PSMC3(4), PSMD1(6), PSMD12(2), PSMD13(3), PSMD2(4), PSMD6(1) 6878598 48 39 47 23 26 6 2 10 4 0 0.569 1.000 1.000 545 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD4(9), CD8A(2), CSF1(12), CSF2(2), CSF3(4), EPO(5), IL11(3), IL2(4), IL3(3), IL4(1), IL5(4), IL6(2), IL7(5), IL9(1) 2580061 57 39 55 37 38 2 1 6 10 0 0.374 1.000 1.000 546 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(16), GOT1(6), GOT2(6), TAT(21), TYR(11) 2008554 60 38 58 30 44 5 3 2 6 0 0.252 1.000 1.000 547 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(16), CCNE1(4), CDC34(4), CDK2(1), CUL1(3), E2F1(6), RB1(10), SKP2(2), TFDP1(2) 3635220 48 38 48 20 28 2 4 6 6 2 0.260 1.000 1.000 548 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(16), HK1(3), HK2(15), HK3(15), IMPA1(1), PGM1(6), PGM3(1), TGDS(1) 4367056 58 38 56 38 41 5 1 6 5 0 0.625 1.000 1.000 549 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(9), ALPL(11), ALPP(9), ALPPL2(12), DHFR(1), FPGS(3), GGH(4), SPR(4) 2730835 53 37 49 27 37 5 4 1 6 0 0.0732 1.000 1.000 550 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 6 ATM(16), ATR(22), CDC25C(5), CHEK1(2), CHEK2(2) 6462961 47 37 46 26 33 3 2 5 4 0 0.890 1.000 1.000 551 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(8), POLR2A(13), POLR2B(14), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(2), POLR2H(2), POLR2J(2), POLR2L(1), POLRMT(4) 5721949 49 37 47 27 27 5 2 11 4 0 0.664 1.000 1.000 552 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(7), JAK2(8), JAK3(11), MAPK1(4), MAPK3(3), STAT3(11), TYK2(8) 4971829 52 37 52 41 27 6 4 8 7 0 0.964 1.000 1.000 553 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(25), GNA12(3), PRKACB(4), PRKACG(10), PRKAG1(3), PRKAR2A(1), PRKAR2B(5) 4312019 51 36 51 32 32 4 1 8 6 0 0.845 1.000 1.000 554 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(1), ECHS1(3), HADH(3), HADHA(6), HADHB(6), HSD17B10(2), HSD17B4(6), MECR(5), PPT1(5), PPT2(4) 3623871 41 36 41 17 24 4 4 5 4 0 0.322 1.000 1.000 555 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(2), ASL(7), CPS1(29), GLS(2), GLUD1(2), GOT1(6) 3274065 48 36 45 23 31 4 2 9 2 0 0.486 1.000 1.000 556 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 AOC2(9), AOC3(9), CES1(21), ESD(3) 2570858 42 35 39 24 32 2 1 3 4 0 0.487 1.000 1.000 557 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(13), EIF2AK4(16), EIF2B5(3), EIF2S1(1), EIF2S3(2), EIF5(2), GSK3B(3), PPP1CA(3) 4952542 43 34 42 20 23 4 1 9 6 0 0.633 1.000 1.000 558 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNA1(1), IFNAR1(3), IFNAR2(8), IFNB1(6), JAK1(7), STAT1(5), STAT2(6), TYK2(8) 4609311 44 34 44 26 27 3 1 8 5 0 0.686 1.000 1.000 559 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CCNE1(4), CDC34(4), CDK2(1), CUL1(3), E2F1(6), FBXW7(11), RB1(10), TFDP1(2) 3483175 41 33 40 17 18 2 5 5 9 2 0.395 1.000 1.000 560 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(4), PSMA2(1), PSMA4(4), PSMA5(3), PSMA6(5), PSMA7(1), PSMB1(1), PSMB2(2), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(2), PSMC3(4), RPN2(4), UBE2A(1), UBE3A(6) 5529517 41 33 41 21 24 5 2 7 3 0 0.602 1.000 1.000 561 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAD(5), ALAS1(2), ALAS2(6), CPO(5), FECH(3), GATA1(4), HBA1(1), HBB(8), HMBS(1), UROS(1) 3298723 36 32 35 19 27 2 0 2 5 0 0.319 1.000 1.000 562 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(14), ENO1(4), GPI(3), HK1(3), PFKL(3), PGK1(3), PKLR(14), TPI1(1) 3925043 45 32 42 27 29 4 1 5 6 0 0.275 1.000 1.000 563 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 B3GALT1(15), B3GALT2(1), B3GALT5(1), B3GNT5(2), FUT1(4), FUT2(4), FUT3(8), ST3GAL3(2), ST3GAL4(1) 3064649 38 32 36 26 24 6 2 2 4 0 0.672 1.000 1.000 564 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 ALDOA(1), CTSD(4), ESR1(6), GREB1(21), HSPB1(2), HSPB2(1), MTA1(2), MTA3(2), PDZK1(3), TUBA8(5) 4570886 47 32 46 29 33 3 4 3 4 0 0.477 1.000 1.000 565 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(5), ADORA2A(3), ADORA2B(1), ADORA3(12), LTB4R(1), P2RY1(5), P2RY2(10), P2RY6(2) 2546495 39 32 38 34 23 6 2 4 4 0 0.428 1.000 1.000 566 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(7), CLOCK(4), CRY1(7), CRY2(7), CSNK1E(5), PER1(8) 3605154 38 31 37 24 25 5 1 3 4 0 0.867 1.000 1.000 567 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(6), ADSS(2), DHFR(1), IMPDH1(4), MTHFD2(2), POLB(1), POLD1(7), POLG(8), PRPS2(3), RRM1(3), SRM(1) 5315371 38 31 38 36 22 2 2 5 7 0 0.995 1.000 1.000 568 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 11 BFAR(1), CAMP(2), CREB5(9), MAPK1(4), RAF1(11), SNX13(5), SRC(2), TERF2IP(2) 4123067 36 31 34 30 25 3 1 4 3 0 0.976 1.000 1.000 569 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD28(2), CD4(9), CD80(4), HLA-DRA(13), HLA-DRB1(5), IL10(2), IL2(4), IL4(1) 1685448 40 30 38 22 28 0 0 6 5 1 0.230 1.000 1.000 570 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 CYP51A1(1), DHCR7(10), FDFT1(1), FDPS(3), HMGCR(4), HMGCS1(2), IDI1(1), LSS(4), MVD(1), MVK(2), NSDHL(3), PMVK(2), SQLE(4) 5613075 38 30 38 28 19 8 1 8 2 0 0.958 1.000 1.000 571 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS1(3), DHRS2(8), DHRS3(5), DHRS7(1), DHRSX(6), ESCO1(2), ESCO2(4), NAT6(5), PNPLA3(3), SH3GLB1(2) 7104319 39 30 39 27 23 3 4 6 3 0 0.960 1.000 1.000 572 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CDC25A(8), CDC25B(4), CDC25C(5), CSK(1), GRB2(2), PRKCA(9), PTPRA(9), SRC(2) 3961867 40 30 39 27 28 4 1 3 4 0 0.785 1.000 1.000 573 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(10), PLCG1(9), PRKCA(9), PTK2B(12) 2884962 40 29 38 33 29 3 1 2 5 0 0.751 1.000 1.000 574 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BAG4(3), BIRC3(7), CASP8(9), RIPK1(3), TNF(1), TNFRSF1A(4), TNFRSF1B(4), TRAF2(2) 3515682 33 29 33 16 22 1 2 3 5 0 0.416 1.000 1.000 575 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(10), FDFT1(1), FDPS(3), HMGCR(4), IDI1(1), LSS(4), MVD(1), MVK(2), NQO1(2), NQO2(1), PMVK(2), SQLE(4) 4698459 35 28 35 25 17 6 1 8 3 0 0.911 1.000 1.000 576 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 9 CASP3(2), CASP7(4), DFFA(2), DFFB(2), GZMB(3), HMGB1(1), HMGB2(2), TOP2A(11), TOP2B(9) 3787166 36 28 35 13 24 2 4 2 4 0 0.358 1.000 1.000 577 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 10 ACLY(12), ACO1(8), ACO2(5), ACSS1(2), ACSS2(4), FH(3), IDH2(2), MDH1(3), MDH2(4) 5343862 43 28 41 32 25 0 2 7 9 0 0.912 1.000 1.000 578 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(3), B4GALT1(2), B4GALT2(2), B4GALT3(3), B4GALT5(3), FUT8(8), ST3GAL1(8), ST3GAL2(1), ST3GAL3(2), ST3GAL4(1) 3358600 33 28 33 23 18 7 2 3 3 0 0.826 1.000 1.000 579 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CCNE1(4), CDK2(1), CDKN1B(1), CUL1(3), E2F1(6), RB1(10), SKP2(2), TFDP1(2), UBE2M(1) 3665141 30 28 30 16 13 2 4 3 6 2 0.661 1.000 1.000 580 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 22 CDC34(4), NRF1(7), UBE2A(1), UBE2D1(1), UBE2D3(3), UBE2E1(1), UBE2E3(1), UBE2G2(1), UBE2H(1), UBE2I(2), UBE2J1(2), UBE2L3(1), UBE2L6(2), UBE2M(1), UBE2N(1), UBE2S(2), UBE3A(6) 4280909 37 28 37 20 23 4 2 4 4 0 0.743 1.000 1.000 581 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(6), ACAA2(1), ACAT2(1), ECHS1(3), EHHADH(6), HADHA(6), HADHB(6), SDS(3) 3568463 32 27 31 19 21 4 1 2 4 0 0.745 1.000 1.000 582 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT2(1), BDH1(5), HMGCL(4), HMGCS1(2), HMGCS2(18), OXCT1(4), OXCT2(5) 3051553 39 27 37 22 24 5 1 4 5 0 0.714 1.000 1.000 583 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 CCL2(3), CSF1(12), IL6(2), LDLR(17), LPL(6) 2287921 40 27 39 22 24 7 2 6 1 0 0.457 1.000 1.000 584 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CCL2(3), CSF1(12), IL1B(8), MST1R(10), TNF(1) 2797568 34 27 33 27 25 4 1 2 2 0 0.855 1.000 1.000 585 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 GRB2(2), HRAS(3), PTK2B(12), SHC1(2), SOS1(10), SRC(2) 3758030 31 26 31 29 20 3 0 6 2 0 0.997 1.000 1.000 586 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RAN(1), RANBP2(25), RANGAP1(3) 3635217 29 26 28 13 20 2 1 1 5 0 0.681 1.000 1.000 587 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 FOS(2), JUN(1), KEAP1(2), MAFG(2), MAPK1(4), MAPK14(5), MAPK8(2), NFE2L2(4), PRKCA(9) 3783534 31 25 29 18 22 1 0 3 5 0 0.684 1.000 1.000 588 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(29), PDXK(1), PNPO(1), PSAT1(4) 2078451 35 25 33 23 27 1 2 4 1 0 0.801 1.000 1.000 589 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(4), PSMA2(1), PSMA4(4), PSMA5(3), PSMA6(5), PSMA7(1), PSMB1(1), PSMB10(2), PSMB2(2), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(2), PSMB8(4) 3756764 32 25 32 12 17 4 2 7 2 0 0.364 1.000 1.000 590 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 FUT1(4), FUT2(4), FUT3(8), FUT5(8), FUT6(4), ST3GAL3(2) 2140316 30 24 29 18 13 6 3 3 5 0 0.402 1.000 1.000 591 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(10), EPHX2(6), HSD3B7(5), RDH11(2), RDH12(2), RDH13(3), RDH14(1) 2057178 29 24 29 20 18 2 3 3 3 0 0.670 1.000 1.000 592 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 LHPP(1), MTMR1(6), MTMR2(3), MTMR6(2), NFS1(4), TPK1(10) 2729917 26 24 26 12 16 1 2 2 5 0 0.658 1.000 1.000 593 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(7), APOBEC1(3), APOBEC2(5), APOBEC3A(2), APOBEC3B(2), APOBEC3C(2), APOBEC3F(4), APOBEC3G(3) 3153147 28 24 27 37 20 2 3 2 1 0 1.000 1.000 1.000 594 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNH(1), CDC25A(8), CDC25B(4), CDC25C(5), CDK7(2), MNAT1(2), SHH(3), XPO1(3) 3720288 28 24 28 13 17 3 3 4 1 0 0.552 1.000 1.000 595 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(2), ST3GAL1(8), ST3GAL2(1), ST3GAL4(1), ST3GAL5(3), ST6GALNAC2(3), ST6GALNAC4(4), ST8SIA1(1) 2421539 23 23 23 13 14 3 2 3 1 0 0.470 1.000 1.000 596 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAD(5), ALAS1(2), ALAS2(6), CPOX(4), FECH(3), HMBS(1), PPOX(3), UROS(1) 3228730 25 22 25 12 17 2 1 2 3 0 0.405 1.000 1.000 597 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNG(4), IFNGR1(3), IFNGR2(4), JAK1(7), JAK2(8), STAT1(5) 3480656 31 22 29 13 14 1 1 5 10 0 0.674 1.000 1.000 598 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(5), CS(2), FH(3), IDH2(2), MDH1(3), OGDH(9), SDHA(4) 4043724 28 22 28 23 17 0 2 6 3 0 0.952 1.000 1.000 599 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 ADAM17(1), DLL1(3), FURIN(7), NOTCH1(9), PSEN1(3) 3928050 23 22 23 21 12 4 2 4 1 0 0.941 1.000 1.000 600 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CCR5(10), CD28(2), CD3D(7), CD3E(2), CD3G(1), CD4(9) 1367799 31 22 30 23 22 2 0 3 4 0 0.631 1.000 1.000 601 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT2(1), ACYP1(1), ECHS1(3), EHHADH(6), GCDH(6), HADHA(6), SDS(3) 3331751 26 21 25 12 17 4 0 3 2 0 0.398 1.000 1.000 602 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 8 ACO1(8), ACO2(5), FH(3), IDH2(2), MDH1(3), MDH2(4) 3464572 25 21 23 17 14 0 2 3 6 0 0.829 1.000 1.000 603 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 11 ACTA1(4), ACTR2(3), ACTR3(2), ARPC1B(3), ARPC2(1), ARPC3(2), ARPC4(1), CDC42(2), WASF1(5), WASL(4) 3291311 27 21 27 14 15 4 2 4 2 0 0.681 1.000 1.000 604 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA10(4), NDUFA4(1), NDUFB2(3), NDUFB5(3), NDUFB6(2), NDUFB7(2), NDUFS1(2), NDUFS2(3), NDUFV1(1), NDUFV2(1) 2985660 22 21 22 13 13 1 1 6 1 0 0.865 1.000 1.000 605 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 ASRGL1(6), GBA(7), GGT1(8), SHMT1(2), SHMT2(3) 2292319 26 18 25 15 18 3 0 3 2 0 0.432 1.000 1.000 606 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 8 CHUK(2), DNAJC3(3), EIF2S1(1), NFKB1(6), NFKBIA(2), RELA(4) 3782875 18 18 18 9 10 3 1 2 2 0 0.595 1.000 1.000 607 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(4), GSTZ1(1), HGD(15) 956700 20 17 20 19 13 3 2 0 2 0 0.932 1.000 1.000 608 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDHB(1), BCKDK(2), CBS(7), CTH(1), MUT(5) 2158481 16 16 16 10 11 2 1 1 1 0 0.703 1.000 1.000 609 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(4), RAB1A(2), RAB27A(3), RAB3A(4), RAB4A(2), RAB5A(2) 1797950 17 15 16 12 13 2 0 1 1 0 0.792 1.000 1.000 610 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(6), ARG1(2), GLS(2), GLUD1(2), OAT(4), PRODH(2) 2324817 18 14 18 17 5 5 3 3 2 0 0.987 1.000 1.000 611 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(1), PGLYRP2(19) 780976 20 13 19 14 14 2 1 2 1 0 0.756 1.000 1.000 612 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(4), IFNG(4), IL12A(4), IL12B(3), IL18(3), IL2(4) 1253962 22 13 21 10 14 2 0 1 5 0 0.317 1.000 1.000 613 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 ATP6V0C(1), GGT1(8), SHMT1(2), SHMT2(3) 1737524 14 11 14 15 9 2 0 2 1 0 0.930 1.000 1.000 614 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(4), HLCS(7) 1320714 11 11 11 11 7 0 1 2 1 0 0.936 1.000 1.000 615 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDFT1(1), FDPS(3), GGPS1(1), IDI1(1), IDI2(1), SQLE(4) 1813037 11 11 11 7 6 1 1 3 0 0 0.769 1.000 1.000 616 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(5) 909034 5 5 5 5 5 0 0 0 0 0 0.858 1.000 1.000