Hybridization REF p difference q subclass Composite Element REF p difference q subclass CDKN1B|P27 0.000421653826726124 1.64283641511299 0.00132820955418729 1 NDRG1|NDRG1_PT346 1.79268240183382e-08 1.2595016413902 3.31257174673973e-07 1 CDH1|E-CADHERIN 4.22558685749772e-12 1.21479430034536 2.66211972022356e-10 1 SRC|SRC_PY527 1.10015584467941e-16 1.07779462593169 1.03964727322204e-14 1 PDCD4|PDCD4 6.03270609066945e-08 0.886211339206192 7.12613406960329e-07 1 AKT1 AKT2 AKT3|AKT_PS473 6.9635876804897e-07 0.818636108181296 5.26447228645021e-06 1 ERBB2|HER2 0.00102121348747661 0.776250616380785 0.00275727641618685 1 IGFBP2|IGFBP2 0.000204642467878653 0.757949874360996 0.000716248637575285 1 CTNNB2|BETA-CATENIN 2.61310821790743e-05 0.711770948990424 0.000133480392752569 1 MAPK1 MAPK3|MAPK_PT202_Y204 7.5227022948525e-08 0.682944275767475 8.36347490427719e-07 1 GSK3A GSK3B|GSK3_PS9 1.0057290459972e-09 0.635196344319023 3.80165579386942e-08 1 EGFR|EGFR_PY1068 0.000764046450476688 0.530438981302426 0.00224676773152792 1 GSK3A GSK3B|GSK3-ALPHA-BETA_PS21_S9 2.67828813820866e-08 0.520159209471912 3.77723004876463e-07 1 RPS6|S6_PS235_S236 0.000617364355691922 0.514127202467284 0.00188196553589957 1 ERBB2|HER2_PY1248 0.00162324019206806 0.510672296925311 0.00414584319325491 1 MAPK14|P38_PT180_Y182 3.36823273380382e-09 0.493730166116981 9.09422838127031e-08 1 PKC|PKC-PAN_BETAII_PS660 4.75223717736435e-07 0.492167297009097 3.90509924574723e-06 1 RB1|RB_PS807_S811 0.000200568397832303 0.475453423219438 0.000715234475288779 1 EIF4EBP1|4E-BP1_PT37_T46 1.04386367585499e-08 0.440886396791095 2.19211371929548e-07 1 SHC1|SHC_PY317 2.73231262718719e-08 0.431698600528567 3.77723004876463e-07 1 AKT1 AKT2 AKT3|AKT_PT308 0.000911063239440857 0.401429851586977 0.00253221988609297 1 SRC|SRC_PY416 5.89784109801636e-05 0.379276037100223 0.00025333908352843 1 NFKB1|NF-KB-P65_PS536 4.36782839881795e-05 0.365936729205075 0.000196552277946808 1 TSC2|TUBERIN_PT1462 1.49315079438099e-05 0.35419282652362 8.06301428965735e-05 1 JUN|C-JUN_PS73 9.83463394367808e-10 0.350732188290456 3.80165579386942e-08 1 ACACA ACACB|ACC_PS79 6.05828914148175e-05 0.348535128270029 0.000254448143942234 1 CTNNB1|ALPHA-CATENIN 5.29357112583543e-08 0.324261549340728 6.66989961855264e-07 1 TSC2|TUBERIN 3.48779771717216e-05 0.311882212863549 0.000173472044354089 1 RPS6|S6_PS240_S244 0.0066081656535554 0.306543576047558 0.0156117913565246 1 RPS6KA1|P90RSK_PT359_S363 3.4843600068128e-06 0.298330553649856 2.12433561705684e-05 1 EIF4G1|EIF4G 0.00037677303441057 0.298184753567028 0.00124930006146663 1 PTEN|PTEN 0.000158919678923544 0.285798357849027 0.00058893763365784 1 BECN1|BECLIN 0.00230564766677561 0.271821862761092 0.00565931700026741 1 RPS6KA1|P90RSK 4.22349606905796e-05 0.239601428570699 0.000196552277946808 1 BAP1|BAP1-C-4 5.76724657779639e-05 0.237274915412384 0.00025333908352843 1 AKT1S1|PRAS40_PT246 1.58523451965154e-05 0.225350870873125 8.32248122817059e-05 1 SRC|SRC 0.000835281629708031 0.222714554143313 0.00239194284870936 1 PRKAA1|AMPK_PT172 0.00724880274196 0.218000645987871 0.0169138730645733 1 BAD|BAD_PS112 1.44476357619547e-07 0.208006814350144 1.51700175500524e-06 1 FRAP1|MTOR_PS2448 2.7979481842701e-08 0.204325535056655 3.77723004876463e-07 1 FOXO3|FOXO3A 0.00993973086338877 0.179920625912703 0.0223643944426247 1 ATM|ATM 0.0407292689185466 0.173425026845516 0.0769783182560531 1 RPS6KB1|P70S6K 0.015497971872727 0.144677390322375 0.0325457409327267 1 MAP2K1|MEK1_PS217_S221 0.0145814339969855 0.133199444970635 0.0309650677014636 1 FRAP1|MTOR 0.00803179354400429 0.127737057849027 0.0185123046319123 1 FOXO3|FOXO3A_PS318_S321 0.000371438069103086 0.122584763891957 0.00124930006146663 1 GATA3|GATA3 0.0130553173080257 0.117184645851101 0.0283615513932972 1 MAPK8|JNK_PT183_PY185 0.00172983490590502 0.113482252924513 0.00430182627915854 1 RPS6KB1|P70S6K_PT389 0.0322785960058791 0.111401081203479 0.062893346856816 1 PRKCD|PKC-DELTA_PS664 0.0455877901548138 0.0725432691488988 0.0836513819345612 1 ARAF|A-RAF_PS299 0.0428844945927776 0.0635934359648899 0.0797978176242712 1 CCNE2|CYCLIN_E2 0.0284113400220172 -0.0712723935306415 0.0559348256683464 1 BAK1|BAK 0.0119932686018461 -0.0720286396291095 0.026667385479399 1 STMN1|STATHMIN 0.0279782677470582 -0.0777056614714331 0.0558063250239999 1 CHEK1|CHK1 0.0430654888765908 -0.0808089663568465 0.0797978176242712 1 ERRFI1|MIG-6 0.0126286344196941 -0.0821513025791574 0.0277536268060719 1 STK11|LKB1 0.000391204689513756 -0.0856360067360357 0.00125659472016244 1 PGR|PR 7.43585324441087e-05 -0.0858300706015001 0.000299016226211416 1 BRCA2|BRCA2 0.0134863149605202 -0.0908255149762209 0.0289649264492991 1 ESR1|ER-ALPHA_PS118 0.00474211650566446 -0.0929747839685605 0.0114905130714177 1 EGFR|EGFR_PY1173 0.0191911487703863 -0.0989806568220555 0.0394252947565545 1 BCL2L1|BCL-XL 0.0280507982924867 -0.108884992195819 0.0558063250239999 1 ANXA7 |ANNEXIN_VII 0.047324781271789 -0.111597622728695 0.0852530138073563 1 AR|AR 0.000111556973999144 -0.113811405955793 0.000428590945435993 1 PRDX1|PRDX1 0.019570290601502 -0.114210153731408 0.0397718808998266 1 EIF4EBP1|4E-BP1_PT70 0.00167603227665547 -0.114477900959783 0.00422360133717178 1 KDR|VEGFR2 0.0473627854485313 -0.121304293825407 0.0852530138073563 1 PIK3CA |PI3K-P110-ALPHA 0.00141364599320618 -0.138730107983402 0.00371082073216622 1 NF2|NF2 0.000948253691363064 -0.147755574010693 0.00259739054590752 1 LCK|LCK 0.0351297611662957 -0.149374462643473 0.067750253677856 1 CDH2|N-CADHERIN 0.000867877027278961 -0.149961357927865 0.00244819042023468 1 RAD51|RAD51 0.016067833780761 -0.151066207015161 0.0333716547754267 1 GSK3A GSK3B|GSK3-ALPHA-BETA 0.0014981966777324 -0.151388131850303 0.00387889276837567 1 RPTOR|RAPTOR 2.47766824040343e-07 -0.160485579459783 2.22990141636309e-06 1 BID|BID 7.69656227744169e-06 -0.165348506380306 4.40803112253479e-05 1 BCL2L11|BIM 0.0397438305710756 -0.167791675544526 0.0758745856356898 1 MS4A1|CD20 2.2169622675621e-07 -0.169902531983722 2.09502934284618e-06 1 EEF2|EEF2 0.000447229283043728 -0.172963899074529 0.00138567761467647 1 RAD50|RAD50 0.000727943010416534 -0.176368799602936 0.0021838290312496 1 DVL3|DVL3 1.52803170849972e-06 -0.178733423984679 1.0696221959498e-05 1 WWTR1|TAZ 2.72874142889046e-09 -0.186021485095914 8.59553550100495e-08 1 ACVRL1|ACVRL1 4.14096370385576e-07 -0.19225801499234 3.5574642728579e-06 1 SMAD3|SMAD3 5.89457115976095e-07 -0.194354918341526 4.64197478831175e-06 1 PCNA|PCNA 0.0011212871409604 -0.195300693262847 0.00298483478368332 1 G6PD|G6PD 0.000368793921167507 -0.196255976512767 0.00124930006146663 1 EIF4EBP1|4E-BP1_PS65 1.9279518102718e-08 -0.200405311035908 3.31257174673973e-07 1 YAP1|YAP 4.42288135299602e-09 -0.212929473727737 1.04490571964531e-07 1 BAX|BAX 9.74105336004079e-05 -0.219536587448133 0.000383553976051606 1 PARK7|DJ-1 3.63330334298533e-05 -0.219994172934089 0.00017607546969852 1 PIK3R1/2|PI3K-P85 6.87521786028886e-05 -0.220341813573891 0.000282481777303173 1 ETS1|ETS-1 4.26931512728183e-05 -0.234700028745452 0.000196552277946808 1 EIF4EBP1|4E-BP1 0.000392270309468697 -0.235255256064794 0.00125659472016244 1 YWHAZ|14-3-3_ZETA 2.68189159709845e-06 -0.282522770266677 1.68959170617202e-05 1 PEA15|PEA15_PS116 0.00634973537417703 -0.304204142495691 0.01519113905974 1 COL6A1|COLLAGEN_VI 1.11726106826548e-05 -0.305659395003671 6.21065711476987e-05 1 TGM2|TRANSGLUTAMINASE 1.6578304288474e-06 -0.327823322350622 1.11903553947199e-05 1 MAPK1|ERK2 1.26525269685251e-06 -0.328818909891159 9.19741383481248e-06 1 SERPINE1|PAI-1 0.00829755411611754 -0.352066068685445 0.0188944304571833 1 TTF1|TTF1 3.64163494019259e-06 -0.361550770175231 2.15084063655125e-05 1 HSPA1A|HSP70 0.000772697897086321 -0.378169321768114 0.00224676773152792 1 ANXA1|ANNEXIN-1 0.000199785765496481 -0.380546263969358 0.000715234475288779 1 PEA15|PEA15 4.09191938231041e-17 -0.422796428288382 7.73372763256668e-15 1 CCND1|CYCLIN_D1 0.00011338384799894 -0.429693868773221 0.000428590945435993 1 FN1|FIBRONECTIN 1.81434540793087e-07 -0.444546577097351 1.80479622157334e-06 1 GAPDH|GAPDH 2.39935366316032e-06 -0.51362207218752 1.56371669771483e-05 1 CASP7|CASPASE-7_CLEAVEDD198 4.07968391040532e-10 1.0567074155576 1.88063477821123e-09 2 CLDN7|CLAUDIN-7 4.26129974303129e-10 0.850282884116797 1.91758488436408e-09 2 SERPINE1|PAI-1 1.77566562930756e-09 0.791413054029744 6.84899599875773e-09 2 TFRC|TFRC 6.83940336773213e-11 0.730631725527084 3.49364117973344e-10 2 FASN|FASN 5.5135049679019e-11 0.541053977848692 2.8945901081485e-10 2 PCNA|PCNA 5.84600260158602e-16 0.52340762765988 1.12045814262817e-14 2 ASNS|ASNS 5.97650048989081e-07 0.494379780089381 1.56883137859634e-06 2 ITGA2|CD49B 2.28086750613171e-12 0.480532736200968 1.43694652886298e-11 2 CCNE1|CYCLIN_E1 3.20293351124625e-06 0.476756191717891 7.76095427725053e-06 2 GAPDH|GAPDH 8.2010513731249e-10 0.473578650562481 3.52272433981956e-09 2 EIF4EBP1|4E-BP1 2.51646150297682e-12 0.472736039462348 1.53422975504071e-11 2 ACACA|ACC1 5.88323882853335e-06 0.457069798476094 1.389915173241e-05 2 YWHAZ|14-3-3_ZETA 6.1616119700597e-09 0.451988968957397 2.11735393152961e-08 2 CCNB1|CYCLIN_B1 4.71119341254687e-07 0.442998909441287 1.27202222138766e-06 2 ANXA1|ANNEXIN-1 3.17685049388447e-08 0.415878297316842 9.84302857941254e-08 2 C12ORF5|TIGAR 1.06894691374021e-05 0.415310545571202 2.37683490231647e-05 2 FN1|FIBRONECTIN 1.62083916142272e-07 0.402502283324379 4.57221793296857e-07 2 EIF4E|EIF4E 1.42210796188129e-20 0.391620516613989 1.34389202397782e-18 2 G6PD|G6PD 1.9528152390301e-09 0.391528421569502 7.38164160353378e-09 2 BAX|BAX 5.88234490321292e-13 0.381905210672074 4.63234661128017e-12 2 MYH9|MYOSIN-IIA_PS1943 0.00010927277653807 0.368161121921704 0.00021970802942229 2 XRCC1|XRCC1 6.29288890480658e-15 0.343484542326301 6.99621178240261e-14 2 PRDX1|PRDX1 1.28138102190884e-08 0.329735488463161 4.24878970422405e-08 2 CHEK1|CHK1 2.41931288862912e-07 0.317453728141997 6.62681356450585e-07 2 CHEK2|CHK2 2.2385416462552e-05 0.295617711381651 4.70093745713592e-05 2 CDC2|CDK1 0.000710688903248477 0.291255983616058 0.00125532899732675 2 PREX1|PREX1 1.0337220896296e-09 0.280287125455919 4.24724945521727e-09 2 PDK1|PDK1 7.18454930612144e-16 0.251664424180276 1.18736404382162e-14 2 SRC|SRC 8.3097494864347e-06 0.251289966906111 1.86969363444781e-05 2 PECAM1|CD31 1.52128298288595e-12 0.232606450325857 1.06489808802016e-11 2 CTNNB1|ALPHA-CATENIN 4.12256718471e-05 0.23258465877871 8.46918693380641e-05 2 PDK1|PDK1_PS241 2.30231848557556e-09 0.230072488493386 8.53212144654472e-09 2 BIRC2 |CIAP 4.16512255178562e-15 0.229249701698677 4.92005101429676e-14 2 PARK7|DJ-1 1.13852405134861e-08 0.226578407340933 3.84251867330156e-08 2 SRC|SRC_PY416 0.000851639887453479 0.225756520307826 0.00147669668558447 2 MAPK14|P38_MAPK 0.0007452186935733 0.219206638449175 0.00130413271375327 2 GSK3A GSK3B|GSK3-ALPHA-BETA 5.20072124664367e-08 0.217062358717669 1.5602163739931e-07 2 TP53|P53 0.000702473539478008 0.198820521543268 0.00125252357510701 2 YAP1|YAP 7.26050572762394e-06 0.193834646631873 1.65329588255533e-05 2 MAPK14|P38_PT180_Y182 0.0486914695652111 0.180527308468039 0.0630321078618144 2 STMN1|STATHMIN 1.65780380234799e-09 0.178540802514891 6.66648763071851e-09 2 BCL2L11|BIM 0.00332103024392906 0.171303301710279 0.0051448747221524 2 BCL2L1|BCL-XL 8.42325823187488e-07 0.16672811726223 2.13630620559407e-06 2 NRAS|N-RAS 2.04841210988504e-12 0.164384036240947 1.3826781741724e-11 2 SMAD4|SMAD4 5.34337872776472e-11 0.160233389544376 2.88542451299295e-10 2 RAF1|C-RAF_PS338 7.07552886084357e-08 0.145502350710427 2.08949211671787e-07 2 STAT3|STAT3_PY705 0.00232745662840551 0.14488452111495 0.00375973763050121 2 COL6A1|COLLAGEN_VI 0.00650252872945813 0.143770219889041 0.00967699157376052 2 MAP2K1|MEK1_PS217_S221 0.000265420005961437 0.141438056267329 0.000511881440068486 2 STK11|LKB1 3.24788199081417e-08 0.134601921076153 9.90080155264319e-08 2 RAD51|RAD51 0.00417214152163722 0.133999968504175 0.00641085160641817 2 BID|BID 2.13328272966204e-05 0.125002971339381 4.53022961692276e-05 2 MET|C-MET_PY1235 3.87386790346514e-05 0.122878333568024 8.04572564565837e-05 2 CHEK2|CHK2_PT68 5.53269693167766e-07 0.122779119774793 1.47278833815081e-06 2 NRG1|HEREGULIN 0.0141402959508634 0.122098993134459 0.0205578148824091 2 PIK3R1/2|PI3K-P85 0.00114576997287241 0.11967674511022 0.00191637632630872 2 RPS6KA1|P90RSK 0.0381912534314029 0.114596892080882 0.0508320204122194 2 EEF2|EEF2 0.0495448148448885 0.110571243301692 0.0637004762291424 2 ANXA7 |ANNEXIN_VII 0.000988735707079439 0.109375250292307 0.00168352296070283 2 SCD1|SCD1 0.0254839618047848 0.108613251389928 0.0356775465266987 2 PIK3CA |PI3K-P110-ALPHA 0.0024762661728342 0.103994931091893 0.00396622293784461 2 MRE11A|MRE11 3.30695898061253e-06 0.0985887700774091 7.91158540931352e-06 2 ADAR|ADAR1 0.00060997790312401 0.0927652508011011 0.00109796022562322 2 CDH3|P-CADHERIN 0.00323030453141786 0.0922855143561558 0.00504568228461137 2 CDKN1B|P27_PT157 0.000557156702416975 0.0867332247520322 0.00102235550249328 2 ERRFI1|MIG-6 0.000477691449089735 0.0771582875591561 0.000885134155666274 2 SMAD3|SMAD3 0.035051471287854 0.0724010150491058 0.0469838870454213 2 CCNE2|CYCLIN_E2 0.00581030607618134 0.072019607898352 0.00871545911427201 2 YWHAE|14-3-3_EPSILON 0.00210538519838699 0.0677294406009829 0.0034303258835788 2 BRCA2|BRCA2 0.0225621256922401 0.0616747109720293 0.0320619680889728 2 ERBB3|HER3_PY1289 0.00275653424638073 0.0583726613316213 0.00437802497954587 2 PGR|PR 0.0052184750902484 -0.0625148024974505 0.00795396606497538 2 RICTOR|RICTOR_PT1135 0.0336253335029931 -0.0658851510259016 0.0453942002290407 2 MS4A1|CD20 0.000592581281218955 -0.0981679561428096 0.00107690252067675 2 RAD50|RAD50 0.0322092452749792 -0.101501512697569 0.0441126620070367 2 XPB1|XPB1 0.0432561237738859 -0.108175462571514 0.0567736624532252 2 NOTCH1|NOTCH1 0.000885335060648188 -0.117560332815585 0.00152116660420461 2 TSC1|TSC1 0.0227728335748373 -0.118348243995972 0.0321198921316735 2 EGFR|EGFR 0.0178084804331359 -0.123242073428207 0.0254985060747173 2 BECN1|BECLIN 0.00963838957799058 -0.123411565335981 0.0141213614747304 2 ETS1|ETS-1 0.00832947078626177 -0.128289959741465 0.0122989842078396 2 PRKAA1|AMPK_ALPHA 0.000247199635895378 -0.128898845690992 0.000481657022517798 2 RPS6KA1|P90RSK_PT359_S363 0.000370214355096451 -0.136879901223803 0.000699705131132292 2 EGFR|EGFR_PY1068 0.0305295247253527 -0.153964221597584 0.0421173735262165 2 SFRS1|SF2 0.0467495095995761 -0.157767715389706 0.0609355676849647 2 RPS6|S6_PS240_S244 0.0170068049964109 -0.171820643268659 0.0245365354528371 2 RPTOR|RAPTOR 8.05363917509384e-07 -0.172210967887341 2.08512027957909e-06 2 CHEK1|CHK1_PS345 4.15396283232112e-15 -0.175528631695278 4.92005101429676e-14 2 PRKCD|PKC-DELTA_PS664 2.1942737993994e-13 -0.184584381242351 1.88508067312039e-12 2 PEA15|PEA15_PS116 0.0331930397961115 -0.192115723754766 0.0451329821688135 2 DVL3|DVL3 9.83883717378638e-08 -0.195204967649978 2.81748519067519e-07 2 EIF4EBP1|4E-BP1_PT37_T46 0.0396255431303057 -0.195388538128325 0.0523722213400544 2 AKT1 AKT2 AKT3|AKT_PT308 0.000169861965277496 -0.195810998541051 0.000337599287153612 2 AKT1S1|PRAS40_PT246 1.12014800310782e-11 -0.209162254083099 6.41539310870842e-11 2 FOXM1|FOXM1 1.86009023809637e-05 -0.211862390684267 3.99496653409334e-05 2 INPP4B|INPP4B 0.00286099389796642 -0.212746841142736 0.00450606538929711 2 PRKAA1|AMPK_PT172 0.00195149718628704 -0.223408031271024 0.00320724320181087 2 KIT|C-KIT 0.00017147900299866 -0.227508438382464 0.000337599287153612 2 EIF4EBP1|4E-BP1_PS65 9.89806399645932e-07 -0.230662557149017 2.46149223069844e-06 2 CDKN1B|P27 0.00575610374671162 -0.231181102496416 0.00870322886502797 2 IRS1|IRS1 1.11509466978643e-10 -0.238633908219295 5.40392032281116e-10 2 MAPK9|JNK2 6.89093785236812e-06 -0.241857014814699 1.60788549888589e-05 2 ERBB2|HER2_PY1248 0.000388526656289142 -0.249993761058343 0.000727044931075721 2 YBX1|YB-1 0.00111214702910846 -0.25875338874915 0.00187674811162053 2 FOXO3|FOXO3A_PS318_S321 1.10633296292055e-13 -0.2592475844874 1.04548464995992e-12 2 TSC2|TUBERIN_PT1462 2.55915075775081e-16 -0.260968012427764 8.06132488691505e-15 2 JUN|C-JUN_PS73 2.12950463368836e-12 -0.262861767432789 1.38784957161069e-11 2 RAF1|C-RAF 9.93309038756303e-10 -0.26375583082667 4.17189796277647e-09 2 SQSTM1|P62-LCK-LIGAND 0.00156649755684873 -0.268708693148869 0.00259708805477553 2 IGFBP2|IGFBP2 0.0303771537786332 -0.276038905739765 0.0421173735262165 2 GSK3A GSK3B|GSK3-ALPHA-BETA_PS21_S9 0.000311203370375906 -0.290313561258683 0.000594115525263093 2 RPS6KB1|P70S6K 8.10670713139761e-05 -0.290314228870197 0.000164749209444532 2 FRAP1|MTOR_PS2448 8.39348134421861e-16 -0.309078733601722 1.22028305696717e-14 2 TTF1|TTF1 6.98686813995844e-06 -0.312663553437519 1.6103879005514e-05 2 TUBA1B|ACETYL-A-TUBULIN-LYS40 1.6068361013357e-05 -0.342301964201485 3.5313025947959e-05 2 BAD|BAD_PS112 1.78691391335771e-16 -0.363425351274571 6.75453459249214e-15 2 CCND1|CYCLIN_D1 3.0242160014581e-08 -0.392611165282109 9.52628040459302e-08 2 FRAP1|MTOR 1.89323239664311e-08 -0.398790850697125 6.06476140619572e-08 2 KDR|VEGFR2 8.53326535706842e-08 -0.400543293467817 2.48121100382451e-07 2 PDCD4|PDCD4 1.63981816152999e-05 -0.40550306372299 3.56236359228929e-05 2 XRCC5|KU80 2.9531370412527e-09 -0.406463000364654 1.07335173230146e-08 2 AKT1 AKT2 AKT3|AKT_PS473 1.81952109478932e-07 -0.427224074765556 5.05719833698796e-07 2 FOXO3|FOXO3A 3.88665660050463e-14 -0.430768262491612 3.86620051313355e-13 2 GSK3A GSK3B|GSK3_PS9 8.47740557775424e-07 -0.445721894165275 2.13630620559407e-06 2 PRKCA |PKC-ALPHA 2.95125222210729e-11 -0.470029886971364 1.64054902934788e-10 2 ATM|ATM 2.34891054117611e-06 -0.485473680218926 5.76550769197773e-06 2 AKT1 AKT2 AKT3|AKT 1.75147683926408e-09 -0.525424546527971 6.84899599875773e-09 2 PRKCA |PKC-ALPHA_PS657 6.50563029771238e-10 -0.535472839251515 2.85945145643637e-09 2 RBM15|RBM15 9.12278449230891e-11 -0.578986421493312 4.53738491854312e-10 2 PKC|PKC-PAN_BETAII_PS660 4.09665829233983e-12 -0.631373799067211 2.41958880391321e-11 2 PTEN|PTEN 5.85912218515598e-09 -0.642965948258683 2.05069276480459e-08 2 NFKB1|NF-KB-P65_PS536 1.21302876012209e-13 -0.667874149854899 1.09172588410988e-12 2 BAP1|BAP1-C-4 1.89400102161839e-15 -0.686242713756318 2.55690137918483e-14 2 EEF2K|EEF2K 7.53881932585154e-16 -0.727653918506688 1.18736404382162e-14 2 BRAF|B-RAF 5.22092704739525e-13 -0.747147138381947 4.29024005199001e-12 2 ERBB2|HER2 5.09095896318605e-09 -0.779646437740061 1.81545517743804e-08 2 TP53BP1|53BP1 2.2207435806331e-19 -0.807841869185967 1.39906845579885e-17 2 GAB2|GAB2 7.43656427997124e-17 -0.84648908610889 3.51377662228641e-15 2 TSC2|TUBERIN 6.47573761958583e-13 -0.858286657809969 4.89565764040689e-12 2 CAV1|CAVEOLIN-1 2.00686008049511e-10 -0.874690011245381 9.48241388033939e-10 2 CDH1|E-CADHERIN 1.45688958059285e-08 -0.894733332454811 4.74745052986291e-08 2 PXN|PAXILLIN 3.16653576395619e-16 -0.924015547126035 8.54964656268171e-15 2 EIF4G1|EIF4G 4.0841119584649e-16 -1.13788161143079 9.64871450187333e-15 2 RICTOR|RICTOR 5.92834996099563e-16 -1.40629672705539 1.12045814262817e-14 2 CTNNB2|BETA-CATENIN 7.47171579169253e-15 -1.41438759131167 7.84530158127716e-14 2 STAT5A|STAT5-ALPHA 2.04134608870882e-23 -1.44502379336983 3.85814410765967e-21 2 MYH11|MYH11 1.28769694123163e-12 -1.9805051991134 9.36056622664531e-12 2 CDH1|E-CADHERIN 7.77587722548435e-22 1.43447135331291 1.46964079561654e-20 3 CTNNB2|BETA-CATENIN 1.49645856146884e-16 1.20962430169211 2.17562052398162e-15 3 EIF4G1|EIF4G 4.30001515141437e-39 1.0517000562317 8.12702863617316e-37 3 VHL|VHL 2.29275348688716e-08 0.991999679635965 8.66660818043346e-08 3 ERBB2|HER2 6.92007506288934e-08 0.917836707459023 2.42202627201127e-07 3 RBM15|RBM15 1.33078822680729e-30 0.850006206565288 8.38396582888593e-29 3 STAT5A|STAT5-ALPHA 1.94006237404694e-12 0.808372348982581 1.26438547825818e-11 3 CLDN7|CLAUDIN-7 3.81986905019712e-07 0.797111393143233 1.22365296692755e-06 3 BAP1|BAP1-C-4 3.47197893564618e-34 0.777444275113659 3.28102009418564e-32 3 TP53BP1|53BP1 3.90101340354373e-28 0.769040163544987 1.22881922211627e-26 3 RPS6|S6 2.9735016104035e-30 0.735687339416917 1.40497951091565e-28 3 TSC2|TUBERIN 5.16088531736708e-24 0.663152064552005 1.08378591664709e-22 3 EEF2K|EEF2K 6.87704397121947e-15 0.654426073489348 6.84084900294989e-14 3 CCNB1|CYCLIN_B1 6.41167702357905e-11 0.599965030660025 3.27515393907146e-10 3 TFRC|TFRC 8.10748750717664e-07 0.595146526458772 2.55385856476064e-06 3 FASN|FASN 5.03936523383762e-10 0.594456723889599 2.38110007298828e-09 3 GAB2|GAB2 9.40254035965742e-16 0.592942919166541 1.04534125175015e-14 3 BRAF|B-RAF 9.95368342068472e-18 0.566445658120677 1.56770513875784e-16 3 XRCC5|KU80 6.58751849044008e-30 0.566057453064035 2.49008198938635e-28 3 FOXM1|FOXM1 3.97357209457709e-14 0.53718209906604 3.75502562937535e-13 3 PTEN|PTEN 1.60125346596138e-12 0.517243825989599 1.08084608952393e-11 3 RPS6|S6_PS235_S236 4.15903977412929e-06 0.448892435226441 1.20932079586221e-05 3 SQSTM1|P62-LCK-LIGAND 3.40813525741768e-07 0.440614217063283 1.11058200629645e-06 3 ACACA|ACC1 3.30943753083334e-05 0.435827993253258 7.81854616659377e-05 3 SFRS1|SF2 2.39632915603612e-08 0.413241925000877 8.88051393119268e-08 3 SYK|SYK 7.51675714246911e-06 0.409113883255263 2.0009395773615e-05 3 FRAP1|MTOR 4.14233980285985e-19 0.402474514435965 7.11729293400465e-18 3 PXN|PAXILLIN 1.12441276780068e-08 0.402334578990351 4.33702067580262e-08 3 TUBA1B|ACETYL-A-TUBULIN-LYS40 9.09075198522884e-08 0.387270477900877 3.12391295492409e-07 3 FOXO3|FOXO3A 1.19390356351397e-06 0.369670308693358 3.63948021780872e-06 3 ACACA ACACB|ACC_PS79 0.000284876651112205 0.358238371457519 0.000572783904895816 3 CCNE1|CYCLIN_E1 0.00311281078882229 0.347874999035965 0.00544741888043901 3 ERBB2|HER2_PY1248 0.0198075401482819 0.341425319554261 0.0301905249034297 3 RPS6|S6_PS240_S244 5.77682139567937e-05 0.322909686910652 0.000133148688266268 3 EIF4EBP1|4E-BP1 4.22157649467318e-08 0.315406217204637 1.53438068748698e-07 3 RB1|RB_PS807_S811 0.0131031375205029 0.307627566372807 0.0208108654737399 3 RPS6KA1|P90RSK 5.05689132163679e-06 0.295105136673809 1.42649620864083e-05 3 RAF1|C-RAF 7.27153661087323e-13 0.280140353566792 5.49728167782016e-12 3 RPS6KB1|P70S6K 4.02747063638395e-10 0.27650243246203 2.00313671125412e-09 3 ATM|ATM 0.00468455737664501 0.23075004125802 0.00790519057308845 3 CHEK2|CHK2 0.000185348506965273 0.230410062936216 0.000398078043368598 3 TSC1|TSC1 1.62858222745364e-07 0.219015665915915 5.49646501765604e-07 3 PRKAA1|AMPK_PT172 0.000512179625546754 0.212039527144236 0.000987774992125883 3 CTNNB1|ALPHA-CATENIN 1.90479605260458e-05 0.208862949906391 4.73692702555613e-05 3 SMAD1|SMAD1 1.60078690966822e-09 0.194744091256516 7.07279437655678e-09 3 CCNE2|CYCLIN_E2 1.76080990495337e-05 0.178639987989098 4.43724096048249e-05 3 RAB25|RAB25 0.0064575530637976 0.170420090405388 0.0108006860978562 3 NOTCH1|NOTCH1 0.00147955853131483 0.160875532656516 0.00271491808173304 3 ERBB3|HER3 0.000837432647253286 0.159939997942982 0.00158274770330871 3 IRS1|IRS1 0.000403844399038799 0.148254162669298 0.000789986108460621 3 RPS6KA1|P90RSK_PT359_S363 0.00833044224835348 0.146627913307895 0.0135728757322311 3 SRC|SRC 0.0294301838325197 0.141735403502381 0.0431186414290405 3 DVL3|DVL3 0.000282328947204355 0.12702897578985 0.000572783904895816 3 BCL2L11|BIM 0.0432088516868141 0.125024479790351 0.0609438281254318 3 ESR1|ER-ALPHA_PS118 3.55471038978417e-09 0.124045713243484 1.46052231232437e-08 3 BAD|BAD_PS112 0.0181110953625232 0.120935894987093 0.0278292440936332 3 AKT1 AKT2 AKT3|AKT 0.0477766908251612 0.113223780676817 0.0663955482790843 3 AKT1S1|PRAS40_PT246 0.00337281916063146 0.111823700816165 0.00584828276476464 3 JUN|C-JUN_PS73 0.0254930683149486 0.0981317656246867 0.0376421086837913 3 XPB1|XPB1 0.0391552741515599 0.08775369000351 0.0556417053732693 3 YBX1|YB-1_PS102 0.0250916035206723 0.0797913431770677 0.0373410477591107 3 RPTOR|RAPTOR 0.0309465613903571 0.0766378699610276 0.0446480923876144 3 GSK3A GSK3B|GSK3-ALPHA-BETA 0.0180853634607447 0.0737961271347118 0.0278292440936332 3 BIRC2 |CIAP 0.0133371672436203 0.0721795967259398 0.021006038408702 3 BAK1|BAK 0.000861223433949021 0.0590236774013785 0.0016115963268947 3 CDKN1B|P27_PT157 0.0166790561610261 -0.0491599660921053 0.0260524100366441 3 AR|AR 0.0449259694847186 -0.049436919512406 0.062896357278606 3 RAF1|C-RAF_PS338 0.0114971057530176 -0.067276106887594 0.0185722477548746 3 CHEK2|CHK2_PT68 0.00245942792107457 -0.070663195183584 0.00438520638757636 3 ERBB3|HER3_PY1289 2.25834728669387e-05 -0.0720652823241855 5.40288148335622e-05 3 NRAS|N-RAS 0.000543854053219629 -0.0872362136477444 0.00103826682887384 3 EGFR|EGFR_PY1173 0.000257357001752781 -0.0882585486783208 0.000534510695948084 3 SMAD3|SMAD3 0.000191782912418045 -0.0907059230234336 0.000407269330865287 3 RAD51|RAD51 0.0213391373669056 -0.108855129263033 0.0322647756987613 3 RAD50|RAD50 0.0220456280233153 -0.109354952608647 0.0330684420349729 3 MS4A1|CD20 0.000104060066203838 -0.11492321548208 0.000234135148958635 3 BECN1|BECLIN 0.00283806667142304 -0.125986934401629 0.00501303365326126 3 YAP1|YAP 0.000389688951354062 -0.127436309830952 0.000775275913746502 3 PRDX1|PRDX1 0.00215614688758155 -0.127464230628446 0.00388106439764679 3 CDH3|P-CADHERIN 0.000138828242495795 -0.12758736670213 0.000305099277112852 3 MRE11A|MRE11 3.1950537950101e-09 -0.13121609674599 1.34192259390424e-08 3 NRG1|HEREGULIN 0.00010907517467263 -0.134984478557018 0.000242531858977966 3 GAPDH|GAPDH 0.0366935497800569 -0.141795358299875 0.052538491730536 3 DIRAS3|DI-RAS3 1.15291472442002e-05 -0.146028111622499 2.9849436015806e-05 3 BID|BID 3.2484229881374e-07 -0.147136130523434 1.07710867501398e-06 3 MAPK8|JNK_PT183_PY185 6.37943826250938e-11 -0.150415621859774 3.27515393907146e-10 3 FOXO3|FOXO3A_PS318_S321 1.08149873778455e-05 -0.151756109323935 2.83893418668444e-05 3 EIF4EBP1|4E-BP1_PS65 0.000405442605929525 -0.154988097588596 0.000789986108460621 3 MAPK14|P38_MAPK 0.00820558607563689 -0.158033348619165 0.0134857023330032 3 YWHAZ|14-3-3_ZETA 0.00716194045371996 -0.16086003267406 0.0118737433837989 3 BAX|BAX 0.00158617638335069 -0.162051458335213 0.00288257054282 3 RICTOR|RICTOR_PT1135 3.93834962301746e-06 -0.165679058653759 1.16304387304734e-05 3 STK11|LKB1 3.89630260149389e-16 -0.169287588804386 4.9093412778823e-15 3 RAB11A RAB11B|RAB11 5.97521219432757e-08 -0.169622767563033 2.13078321646776e-07 3 STAT3|STAT3_PY705 0.000265572024506923 -0.173956675500125 0.000545577311215309 3 BRCA2|BRCA2 4.37875540918042e-13 -0.176315403589348 3.59819466232652e-12 3 PGR|PR 7.07111239238078e-16 -0.177907871275063 8.3527515134998e-15 3 PREX1|PREX1 0.000209530132707588 -0.189481804641228 0.000440013278685935 3 PECAM1|CD31 4.31528956541614e-10 -0.192579152086842 2.0912557124709e-09 3 TGM2|TRANSGLUTAMINASE 0.00137286855869621 -0.202717275254261 0.00254384468229004 3 WWTR1|TAZ 7.81699660450552e-14 -0.209432184773559 6.7155107193252e-13 3 ESR1|ER-ALPHA 1.21564718615591e-09 -0.210843025457018 5.60383702886505e-09 3 STMN1|STATHMIN 9.24998462149104e-13 -0.211939984696115 6.72402728254541e-12 3 CDH2|N-CADHERIN 6.27673562940747e-11 -0.219053560136216 3.27515393907146e-10 3 NDRG1|NDRG1_PT346 0.0306531635824587 -0.225631407608396 0.0445649839775746 3 PARK7|DJ-1 1.60915427614784e-09 -0.226128348432707 7.07279437655678e-09 3 ANXA7 |ANNEXIN_VII 4.28496499226654e-11 -0.229312758046491 2.38193642217169e-10 3 AKT1 AKT2 AKT3|AKT_PS473 0.0121374349136786 -0.237766499153258 0.0194404677854683 3 ETS1|ETS-1 4.30577034308302e-06 -0.238250764749749 1.23301605279196e-05 3 GSK3A GSK3B|GSK3-ALPHA-BETA_PS21_S9 0.00375059905541967 -0.248895090622932 0.00644421110431198 3 SRC|SRC_PY416 4.87260759711039e-05 -0.252870191695363 0.000113694177265909 3 BCL2|BCL-2 3.80704312582472e-06 -0.255111634729699 1.14211293774742e-05 3 MAPK1|ERK2 1.52570647901427e-05 -0.255542952107895 3.89673681802293e-05 3 MAP2K1|MEK1_PS217_S221 8.975008236348e-12 -0.261519257142982 5.30086423959304e-11 3 AKT1 AKT2 AKT3|AKT_PT308 7.71615331180957e-05 -0.261819861027193 0.000175705177823134 3 CDKN1A|P21 0.000149052790326125 -0.282183674498872 0.00032380433760503 3 YWHAB|14-3-3_BETA 5.62350703607462e-14 -0.289685219099624 5.06115633246716e-13 3 YAP1|YAP_PS127 5.26818512405878e-06 -0.294082865879073 1.46424557124575e-05 3 G6PD|G6PD 4.32420559968502e-12 -0.296812811908145 2.72424952780156e-11 3 PEA15|PEA15 7.23975591295613e-13 -0.314726005848998 5.49728167782016e-12 3 SRC|SRC_PY527 0.00403704614399782 -0.334475931004887 0.00687388938032061 3 FN1|FIBRONECTIN 5.76258520151692e-06 -0.335427146855013 1.57844725085029e-05 3 PEA15|PEA15_PS116 2.14186368276219e-05 -0.340305101945489 5.18990046207761e-05 3 MYC|C-MYC 5.87213359501622e-06 -0.341999156001378 1.58547607065438e-05 3 ACVRL1|ACVRL1 3.77419433649197e-26 -0.382555822145739 8.91653411996228e-25 3 CDKN1B|P27 1.99061856023049e-05 -0.401592274516917 4.88606373874757e-05 3 CCND1|CYCLIN_D1 9.74339633901097e-09 -0.425697105690601 3.83646230848557e-08 3 MAPK14|P38_PT180_Y182 1.09979887999365e-06 -0.426363247868045 3.40757357899672e-06 3 ANXA1|ANNEXIN-1 7.0051212219781e-09 -0.448968215731955 2.81695300202949e-08 3 MAPK1 MAPK3|MAPK_PT202_Y204 1.76708933664237e-09 -0.506602906584085 7.59045192330473e-09 3 COL6A1|COLLAGEN_VI 1.03595104688322e-26 -0.527167639152005 2.79706782658469e-25 3 KIT|C-KIT 3.89927466713398e-15 -0.530744449663785 4.09423840049068e-14 3 HSPA1A|HSP70 2.62437024684818e-11 -0.564991958621178 1.50304841410396e-10 3 CAV1|CAVEOLIN-1 3.12452104511586e-16 -1.15525368806629 4.21810341090641e-15 3 RICTOR|RICTOR 1.12542015160746e-12 -1.16021351443847 7.87794106125222e-12 3 MYH11|MYH11 5.38249488381239e-12 -2.09493769877331 3.28158559045336e-11 3 MYH11|MYH11 7.28925802814429e-35 3.3626653205927 1.37766976731927e-32 4 RICTOR|RICTOR 5.39835131913712e-31 2.61410535658636 3.40096133105639e-29 4 CAV1|CAVEOLIN-1 3.20906084466436e-33 1.79902943914079 3.03256249820782e-31 4 HSPA1A|HSP70 7.48529473961978e-09 0.646790786007886 2.72061674190027e-08 4 CCND1|CYCLIN_D1 2.35548049442973e-11 0.581907920172657 1.08664133919913e-10 4 KIT|C-KIT 3.84155010381557e-20 0.541129843254816 5.58502284323956e-19 4 PRKCA |PKC-ALPHA_PS657 2.35726428080235e-11 0.478665421651972 1.08664133919913e-10 4 ACVRL1|ACVRL1 1.40620086830234e-21 0.473143396914221 2.65771964109142e-20 4 COL6A1|COLLAGEN_VI 2.8442319458678e-17 0.472223578787136 3.16211669275891e-16 4 YAP1|YAP_PS127 9.91903790286797e-15 0.467370978346283 7.81124234850853e-14 4 PRKCA |PKC-ALPHA 2.17401555772116e-11 0.437317502744473 1.08664133919913e-10 4 EIF4EBP1|4E-BP1_PS65 3.38816033779065e-13 0.408134542561603 2.37171223645345e-12 4 PEA15|PEA15 1.64428565358734e-15 0.365456123830446 1.41259085694549e-14 4 AKT1 AKT2 AKT3|AKT_PS473 9.47504003177689e-07 0.360333223349709 2.79809775938411e-06 4 PXN|PAXILLIN 1.62327471012621e-05 0.358880085242922 3.83498650267317e-05 4 MYC|C-MYC 1.11720632945759e-06 0.343725109720621 3.24849225026899e-06 4 BCL2|BCL-2 6.15932514010087e-13 0.33471531539192 4.15754446956809e-12 4 KDR|VEGFR2 5.9300759360844e-08 0.326915190679638 1.96628833670167e-07 4 GSK3A GSK3B|GSK3_PS9 1.64285943456849e-07 0.320475113792954 5.2627192056516e-07 4 AKT1 AKT2 AKT3|AKT 2.84700317791843e-09 0.314561808378281 1.12100750130538e-08 4 MAPK1 MAPK3|MAPK_PT202_Y204 9.93428739624253e-05 0.303195924660827 0.000220891802104687 4 PGR|PR 5.67631337669361e-23 0.296238938434906 1.34102903524387e-21 4 STAT5A|STAT5-ALPHA 0.00575387457389469 0.287268383187654 0.0101633859295897 4 AKT1 AKT2 AKT3|AKT_PT308 1.36030041029333e-08 0.283161656531739 4.59101388473999e-08 4 GSK3A GSK3B|GSK3-ALPHA-BETA_PS21_S9 1.41536867395419e-06 0.278182002215126 3.9926071548857e-06 4 INPP4B|INPP4B 8.65983300242058e-05 0.269060356124305 0.000194846242554463 4 TTF1|TTF1 0.0162503417527199 0.268195571445507 0.0249700373273501 4 ESR1|ER-ALPHA 8.8026164785754e-14 0.262531766172398 6.39882505557981e-13 4 RICTOR|RICTOR_PT1135 2.23503859306909e-15 0.255782536929024 1.83661866995677e-14 4 NFKB1|NF-KB-P65_PS536 0.00274335857226487 0.254473033141112 0.00503392980735981 4 FOXO3|FOXO3A_PS318_S321 8.09719028348277e-12 0.253968861121138 4.63748170781286e-11 4 TSC2|TUBERIN_PT1462 1.38417037175217e-09 0.229394791282159 5.56613192045021e-09 4 CDKN1A|P21 0.00228508163891377 0.229391943624822 0.00431880429754703 4 PKC|PKC-PAN_BETAII_PS660 0.000923111661074948 0.216167505983129 0.00185604365896984 4 BRCA2|BRCA2 6.11447460639641e-12 0.214662341597544 3.85211900202974e-11 4 SRC|SRC_PY527 0.0202028838407458 0.197686956416354 0.0303043257611187 4 WWTR1|TAZ 4.36712083944637e-11 0.192894402712799 1.96520437775087e-10 4 FRAP1|MTOR_PS2448 1.24742549215708e-08 0.184301313847511 4.2866076003216e-08 4 FN1|FIBRONECTIN 0.0159628451487333 0.170395197580995 0.0247293256812344 4 TUBA1B|ACETYL-A-TUBULIN-LYS40 0.0106817115959576 0.16365272599541 0.0175551607968347 4 RPS6KB1|P70S6K_PT389 0.00137986525363539 0.161511293672398 0.00271660971809467 4 ATM|ATM 0.0345822376805941 0.159938688948287 0.0498934574170403 4 DIRAS3|DI-RAS3 2.46756342975371e-06 0.153138509454613 6.75897809019495e-06 4 MAPK14|P38_PT180_Y182 0.0264151586621817 0.148464421170653 0.0393107479303334 4 AR|AR 1.07017185148274e-09 0.148362682784745 4.39701043326604e-09 4 STMN1|STATHMIN 7.80181008560301e-07 0.146294855720685 2.3782937196435e-06 4 PRKCD|PKC-DELTA_PS664 1.82690090561409e-06 0.14444813593956 5.07770987001563e-06 4 MS4A1|CD20 9.41592473091277e-07 0.144355531540272 2.79809775938411e-06 4 ANXA1|ANNEXIN-1 0.0132779604212315 0.138731134573562 0.0209127876634396 4 RPTOR|RAPTOR 2.11564080750932e-05 0.132664889322107 4.86955651008835e-05 4 STAT3|STAT3_PY705 0.00473047393067712 0.127373308952295 0.00859672666248054 4 EGFR|EGFR_PY1173 4.56251971163198e-06 0.125028832353782 1.18125510342253e-05 4 ANXA7 |ANNEXIN_VII 2.13848248855732e-05 0.123657815567098 4.86955651008835e-05 4 EGFR|EGFR 0.026998340907383 0.12114268522437 0.0395557087712821 4 BECN1|BECLIN 0.00671694113911948 0.1107532594 0.011646806195354 4 YAP1|YAP 0.00026987813349052 0.110209733520814 0.000579624627610321 4 BID|BID 0.000505430375012085 0.107592604968261 0.00104974000964048 4 IRS1|IRS1 0.00159621075107317 0.101108732564189 0.00307840644849826 4 MRE11A|MRE11 7.64659421429618e-06 0.100186341614867 1.92694174200264e-05 4 RAB11A RAB11B|RAB11 0.00662443552752416 0.0979078997087266 0.0115927621731673 4 CDH2|N-CADHERIN 0.00753171858101679 0.0975897766999353 0.0128242775838935 4 MAP2K1|MEK1_PS217_S221 0.00157882642845322 0.0965463206727214 0.00307627005131607 4 CDH3|P-CADHERIN 0.0020785473511473 0.0879908784174531 0.0039681358521903 4 PRKAA1|AMPK_ALPHA 0.0131788817963056 0.0867428318483517 0.0209127876634396 4 MAPK8|JNK_PT183_PY185 0.000425156627468477 0.0859185399095669 0.000892828917683802 4 DVL3|DVL3 0.0196619478838088 0.0790659103960569 0.0297288652003189 4 PIK3CA |PI3K-P110-ALPHA 0.00850133872475459 0.0767576332530058 0.0141509958285341 4 ARAF|A-RAF_PS299 0.00270858739816163 0.0621804373489981 0.00501885312012302 4 NRAS|N-RAS 0.00743220718562382 0.0614220059352941 0.0127698832552991 4 YWHAE|14-3-3_EPSILON 0.00853552129340152 0.0605083965879767 0.0141509958285341 4 STK11|LKB1 0.0108348905168407 0.057052632241435 0.0176533992041629 4 ERBB3|HER3_PY1289 0.0130146609655985 0.0478191410870718 0.0208455162923569 4 ERRFI1|MIG-6 0.0365852787783554 -0.0352195107532644 0.0523834673417361 4 PDK1|PDK1 0.00502269729263085 -0.07676853897117 0.00895556404063425 4 ESR1|ER-ALPHA_PS118 3.77283380354627e-06 -0.0785593810557854 9.90368873430896e-06 4 YBX1|YB-1_PS102 0.000635909260148018 -0.085888209766128 0.00130637880617365 4 RAD51|RAD51 0.0368677132983017 -0.10464306205223 0.0523909610028498 4 BCL2L1|BCL-XL 0.000948387523072444 -0.106985811062508 0.00188679201958623 4 PREX1|PREX1 0.0178479620326165 -0.108677865685973 0.0272037485819719 4 PDK1|PDK1_PS241 0.000675413102393659 -0.111588172748739 0.00137261372421937 4 EIF4EBP1|4E-BP1_PT70 1.24697016444755e-05 -0.126055146422043 3.06074494909853e-05 4 ERBB2|HER2_PY1248 0.0400726824470975 -0.127316001261021 0.056520425242548 4 RPS6KB1|P70S6K 0.00244725938483458 -0.138541517254493 0.00457952498746273 4 GSK3A GSK3B|GSK3-ALPHA-BETA 7.10397038793444e-06 -0.142265783181707 1.81439243691839e-05 4 SMAD1|SMAD1 8.34350704241052e-08 -0.145639206215579 2.71883246726826e-07 4 CCNE2|CYCLIN_E2 2.27259665330674e-11 -0.148378826769037 1.08664133919913e-10 4 RPS6|S6_PS240_S244 0.0266761226459729 -0.163614095976212 0.0393889623444444 4 MAPK14|P38_MAPK 0.00026875544223192 -0.184646415314608 0.000579624627610321 4 CHEK1|CHK1 1.36471900628508e-05 -0.185068430827149 3.30681913061385e-05 4 PDCD4|PDCD4 0.0129574800337958 -0.19535667899903 0.0208455162923569 4 PTEN|PTEN 0.0154573176948808 -0.203592539154751 0.0241440747465493 4 PRDX1|PRDX1 6.30382331390625e-09 -0.206420969180737 2.43147470679241e-08 4 ACACA ACACB|ACC_PS79 0.000181574195723777 -0.219159743385068 0.000399040965020859 4 BCL2L11|BIM 3.12975794378531e-06 -0.228273891951002 8.45034644822034e-06 4 BAX|BAX 8.17621975965987e-09 -0.23643392367563 2.91481035055962e-08 4 XRCC5|KU80 1.48963002830622e-05 -0.238246170277957 3.56379842215032e-05 4 BIRC2 |CIAP 1.20675771547426e-17 -0.241509652190886 1.42548255140397e-16 4 ERBB2|HER2 0.00815725541325497 -0.274791428047835 0.0137653685098678 4 BAP1|BAP1-C-4 1.13942417535484e-05 -0.277178296310924 2.83356801502717e-05 4 EIF4E|EIF4E 2.64169566902577e-20 -0.285004195854687 4.16067067871559e-19 4 RPS6KA1|P90RSK 5.22217765269926e-10 -0.300917401871041 2.19331461413369e-09 4 SERPINE1|PAI-1 0.00493976585136582 -0.301790298497867 0.00889157853245848 4 VHL|VHL 0.0342369967329316 -0.306128930381448 0.0497753260194159 4 GAPDH|GAPDH 5.4617831881663e-07 -0.306413126133096 1.72046170427238e-06 4 FOXM1|FOXM1 1.021733990973e-11 -0.315951060573562 5.6796389498205e-11 4 RB1|RB_PS807_S811 1.78922120640379e-05 -0.321344799950808 4.17484948160884e-05 4 SQSTM1|P62-LCK-LIGAND 1.33402824736584e-06 -0.322670173392049 3.82017179927491e-06 4 ITGA2|CD49B 7.27069668845685e-09 -0.330430276251648 2.69443465513401e-08 4 YWHAZ|14-3-3_ZETA 1.27635035569978e-10 -0.354900575887847 5.48250493698315e-10 4 XRCC1|XRCC1 1.00062890129816e-25 -0.358411445910019 3.1519810390892e-24 4 SRC|SRC 2.22320242122747e-12 -0.370334058875307 1.44891468142066e-11 4 CDC2|CDK1 7.61274630326671e-07 -0.381588524920233 2.35870336281542e-06 4 SFRS1|SF2 6.63337390873256e-09 -0.394192526310989 2.50741533750091e-08 4 RPS6|S6_PS235_S236 3.38833027837435e-06 -0.402359250186749 9.01963975510919e-06 4 EEF2|EEF2 1.6781090467688e-14 -0.410160635969813 1.26865043935721e-13 4 CHEK2|CHK2 7.98624738949974e-12 -0.430924673740142 4.63748170781286e-11 4 CTNNB2|BETA-CATENIN 0.000389480202773911 -0.437879044986749 0.000827098408137856 4 ASNS|ASNS 8.32802957302749e-09 -0.466466026620168 2.91481035055962e-08 4 CTNNB1|ALPHA-CATENIN 5.44921360267638e-19 -0.475160136995152 7.35643836361311e-18 4 PCNA|PCNA 1.8720027360193e-21 -0.496789920506335 3.21644106461498e-20 4 EIF4EBP1|4E-BP1 1.36113618244467e-26 -0.544185442857272 5.14509476964085e-25 4 SYK|SYK 9.93654831665713e-11 -0.550551069714027 4.3674596089493e-10 4 C12ORF5|TIGAR 8.01417861932305e-12 -0.576550493903555 4.63748170781286e-11 4 RBM15|RBM15 1.25000915095748e-11 -0.584049568935165 6.75004941517039e-11 4 RPS6|S6 1.76595406097319e-16 -0.620557321179379 1.75665956591544e-15 4 ACACA|ACC1 1.60806653263282e-15 -0.622477075731286 1.41259085694549e-14 4 FASN|FASN 5.56644316219178e-17 -0.726035159990304 5.84476532030137e-16 4 CCNE1|CYCLIN_E1 8.03293117144387e-22 -0.742013560380802 1.68691554600321e-20 4 MYH9|MYOSIN-IIA_PS1943 2.34428272889191e-11 -0.830675456367292 1.08664133919913e-10 4 CCNB1|CYCLIN_B1 4.4716666323563e-27 -0.912729389130252 2.11286248378835e-25 4 CDH1|E-CADHERIN 2.15184514641e-11 -1.07564829213626 1.08664133919913e-10 4 CASP7|CASPASE-7_CLEAVEDD198 2.25477986082088e-18 -1.07629680515094 2.84102262463431e-17 4 CLDN7|CLAUDIN-7 2.26749887691089e-16 -1.16846197013782 2.14278643868079e-15 4 TFRC|TFRC 6.9026297969083e-24 -1.32280200690052 1.86371004516524e-22 4 PEA15|PEA15_PS116 7.49159110639271e-17 1.0857976776252 1.41591071910822e-14 5 MYH9|MYOSIN-IIA_PS1943 2.43873141236446e-15 1.08222100499781 2.30460118468441e-13 5 CTNNB2|BETA-CATENIN 8.63370857349521e-08 0.953297164290049 6.27604200150229e-07 5 TFRC|TFRC 4.40477458512499e-08 0.769944034008064 3.46875998578593e-07 5 RBM15|RBM15 1.007889816939e-12 0.76394534822403 3.80982350802942e-11 5 EEF2|EEF2 3.92426250762206e-10 0.7348275271807 6.18071344950474e-09 5 MAPK1|ERK2 1.40966259409675e-11 0.733280567532668 3.33032787855357e-10 5 ETS1|ETS-1 2.2578446598674e-14 0.713966052034992 1.06683160178735e-12 5 STAT5A|STAT5-ALPHA 7.97803971025231e-05 0.680351551192045 0.00028449990664862 5 TGM2|TRANSGLUTAMINASE 1.95603662478272e-07 0.632034741348414 1.19255136156108e-06 5 CCND1|CYCLIN_D1 2.58386118624934e-07 0.560245339034445 1.47984777030644e-06 5 RAD50|RAD50 1.60589167829273e-07 0.554606281871788 1.01171175732442e-06 5 TTF1|TTF1 6.62352428929878e-09 0.552656905031575 6.58866363514458e-08 5 CDH1|E-CADHERIN 0.0080488711457811 0.542002098005331 0.0167882893941539 5 PTEN|PTEN 6.39910507287194e-09 0.528700203004784 6.58866363514458e-08 5 GAPDH|GAPDH 0.000805534245013433 0.44387521938819 0.00223891135746381 5 TP53BP1|53BP1 1.87651310703452e-05 0.439162549845817 7.71002124412009e-05 5 SQSTM1|P62-LCK-LIGAND 0.00240736405911904 0.428602483115227 0.00598673430491445 5 YWHAZ|14-3-3_ZETA 1.12357695705601e-06 0.419598065972253 5.58831697062068e-06 5 SFRS1|SF2 4.08715412967323e-07 0.41870828304743 2.271976854436e-06 5 SYK|SYK 0.00174872230155258 0.397952788261345 0.00452751390401969 5 EIF4G1|EIF4G 0.000373114964592002 0.388656464972663 0.00111934489377601 5 YWHAB|14-3-3_BETA 5.54401039516329e-10 0.382063510272143 8.06013818989125e-09 5 BAP1|BAP1-C-4 7.79580572099543e-07 0.38018207400164 4.0927980035226e-06 5 TSC2|TUBERIN 1.5800646989319e-05 0.36384124599959 6.76897892282376e-05 5 GAB2|GAB2 0.00249843230801086 0.360279730804265 0.00613251566511757 5 PXN|PAXILLIN 0.00344992058965327 0.34608059881684 0.00804981470919096 5 CCNB1|CYCLIN_B1 0.00741477764750505 0.326743987278568 0.0157459884873984 5 XRCC5|KU80 0.000208218194536862 0.292978453708584 0.000642729689567276 5 LCK|LCK 0.0169205352864423 0.288774240950383 0.0316631798924514 5 BRAF|B-RAF 4.13990493777052e-05 0.288113624745489 0.00015968204759972 5 C12ORF5|TIGAR 0.013563553366021 0.287434327565746 0.0258940564260401 5 NF2|NF2 5.78285472612668e-08 0.281498334310552 4.37183817295177e-07 5 CDC2|CDK1 0.0224264514889027 0.281069538734964 0.0407557628019482 5 RAD51|RAD51 6.85135144403628e-11 0.280907237094724 1.29490542292286e-09 5 MAPK9|JNK2 1.52450643927229e-12 0.278264554473209 4.80219528370771e-11 5 MAPK14|P38_MAPK 0.000161387547556956 0.271080266360662 0.000525900801521805 5 RPS6KB1|P70S6K 9.1088453527877e-05 0.253620389921815 0.000313013049395796 5 BAX|BAX 0.000453125985386208 0.246728226034718 0.00133813767559365 5 RPS6|S6 0.00551997827065855 0.235200545777884 0.0121311150366798 5 EIF4EBP1|4E-BP1_PT70 1.70465592895299e-08 0.230516636003007 1.61089985286058e-07 5 CDH2|N-CADHERIN 1.15864174831318e-07 0.227281682439858 8.11049223819226e-07 5 FOXM1|FOXM1 0.0212911860670353 0.215825094681657 0.0390682928802881 5 AKT1 AKT2 AKT3|AKT 0.000924874627662349 0.21221707947567 0.00249716149468834 5 MS4A1|CD20 0.0111500461164906 0.209878193593084 0.0222740624818125 5 PKC|PKC-PAN_BETAII_PS660 0.0462704068140756 0.166749829800847 0.0780813114987526 5 CHEK1|CHK1_PS345 8.65668011403454e-05 0.159423359174139 0.000302983803991209 5 BAD|BAD_PS112 0.0291167556769258 0.149294174212411 0.0509543224346202 5 SMAD3|SMAD3 0.000528822789331206 0.144977377862767 0.00151435616944845 5 RAF1|C-RAF 0.00727834227832934 0.14141755461263 0.0156318942114119 5 DVL3|DVL3 0.000995883679768296 0.139115743971569 0.0026510143024818 5 PRDX1|PRDX1 0.0253851063555662 0.132960555938491 0.0456931914400192 5 PRKAA1|AMPK_ALPHA 0.0283318147016345 0.119703918611673 0.0500440465290553 5 XRCC1|XRCC1 0.00808325044903704 0.10095042436058 0.0167882893941539 5 ERBB3|HER3_PY1289 0.0112942350773821 -0.0546882715557682 0.0222740624818125 5 BAK1|BAK 0.00483480898275879 -0.0636867931776927 0.0110093843101375 5 CDKN1B|P27_PT157 8.42624560118612e-06 -0.0912777477929196 3.70362888052134e-05 5 GSK3A GSK3B|GSK3-ALPHA-BETA 0.0198738654510386 -0.0917410852890924 0.0368251036298656 5 ERBB3|HER3 0.0147382130570397 -0.0941425497706397 0.027855222677805 5 BIRC2 |CIAP 0.0114112456470446 -0.0942099983283215 0.0222740624818125 5 MAPK8|JNK_PT183_PY185 0.0448493838455059 -0.0959699589015856 0.0763651670882938 5 EGFR|EGFR_PY1173 0.0049094528922146 -0.122972327295927 0.0110462690074829 5 CDKN1A|P21 0.0339633170499352 -0.129941950087069 0.0588905222241996 5 DIRAS3|DI-RAS3 0.000745684663982204 -0.138351844771843 0.00210349852974084 5 CHEK1|CHK1 0.00280367844961265 -0.138841859710771 0.0067935285509845 5 NOTCH1|NOTCH1 0.00636282915959424 -0.139282153892017 0.0138226978294634 5 PGR|PR 1.51385172670364e-07 -0.146186116544697 1.01171175732442e-06 5 ACVRL1|ACVRL1 0.00526570195073987 -0.14693413452064 0.0117084431610569 5 RICTOR|RICTOR_PT1135 3.12427482595151e-05 -0.148256737439584 0.000123018321271841 5 MRE11A|MRE11 4.31119317495685e-08 -0.149816038347594 3.46875998578593e-07 5 MAP2K1|MEK1_PS217_S221 0.00131756501589127 -0.151961942646391 0.00345860816671458 5 MET|C-MET_PY1235 0.00018477094118481 -0.152815735496856 0.000582028464732151 5 CHEK2|CHK2_PT68 2.36511993392294e-06 -0.156927750300301 1.11751916877859e-05 5 GATA3|GATA3 0.000175173344576294 -0.158920992551258 0.000561148510591857 5 PDK1|PDK1 4.76956493991182e-05 -0.159722926414844 0.000176754465420262 5 RPS6KA1|P90RSK_PT359_S363 0.0375032070648149 -0.163541653150902 0.0644373285022729 5 SCD1|SCD1 0.00302585171663528 -0.171675647257108 0.00723906296764643 5 RAF1|C-RAF_PS338 0.000210842543667572 -0.172768158127802 0.000642729689567276 5 ARAF|A-RAF_PS299 2.26443539690156e-09 -0.180232719594861 2.51751935302585e-08 5 TSC2|TUBERIN_PT1462 0.000888457129860958 -0.18088200288655 0.00243359996440175 5 TSC1|TSC1 1.61166164829137e-05 -0.182435016645981 6.76897892282376e-05 5 SMAD4|SMAD4 2.88889159992231e-10 -0.183636171413067 4.9636410216847e-09 5 RPS6KB1|P70S6K_PT389 0.013038371799799 -0.184790000776654 0.0251454313281838 5 CDH3|P-CADHERIN 1.79944880186527e-08 -0.195742284346501 1.61950392167874e-07 5 PDK1|PDK1_PS241 1.41861055895101e-06 -0.198490752785539 6.87480501645489e-06 5 YAP1|YAP 7.46359657167144e-05 -0.200695230280891 0.000271273029239597 5 BRCA2|BRCA2 1.0073774395511e-06 -0.201722328537726 5.14579286689616e-06 5 NRG1|HEREGULIN 9.41315327460036e-10 -0.203155739723893 1.27077569207105e-08 5 AR|AR 4.88252147276413e-11 -0.206388900826135 1.02532950928047e-09 5 PECAM1|CD31 5.41309045614058e-06 -0.211923641538682 2.49530267368432e-05 5 MAPK1 MAPK3|MAPK_PT202_Y204 0.0279506137066251 -0.221944477617824 0.0498364716089825 5 YWHAE|14-3-3_EPSILON 3.64826782355444e-12 -0.222476991254784 9.85032312359699e-11 5 STMN1|STATHMIN 2.7471877180381e-08 -0.226267122203116 2.36008399413273e-07 5 ACACA ACACB|ACC_PS79 0.00932714000782159 -0.228940487491525 0.019161189798677 5 NRAS|N-RAS 1.73220336027895e-14 -0.241037460826135 1.06683160178735e-12 5 STAT3|STAT3_PY705 0.000464308231965531 -0.249619012037726 0.00135006547448439 5 ADAR|ADAR1 1.03349903125845e-09 -0.254546579769546 1.30220877938565e-08 5 YAP1|YAP_PS127 0.00205099251228838 -0.260770161882586 0.00516850113096672 5 ESR1|ER-ALPHA 6.54676773761039e-07 -0.261171912001094 3.53525457830961e-06 5 RPS6KA1|P90RSK 0.000104698164569903 -0.263707486892154 0.000353356305423423 5 ERBB2|HER2_PY1248 4.52837032717395e-05 -0.264384851482914 0.000171172398367175 5 SHC1|SHC_PY317 2.16115168416349e-07 -0.275052694252597 1.27643021345906e-06 5 AKT1 AKT2 AKT3|AKT_PS473 0.0114316616970149 -0.28385287650246 0.0222740624818125 5 ACACA|ACC1 0.0033635742925535 -0.285074880477583 0.00794644426615764 5 MYC|C-MYC 0.0095230156581748 -0.297513390604155 0.0193532253698391 5 PIK3CA |PI3K-P110-ALPHA 2.20840421309411e-09 -0.297538169649809 2.51751935302585e-08 5 TUBA1B|ACETYL-A-TUBULIN-LYS40 2.08825199702045e-05 -0.32014433347936 8.39743888163543e-05 5 MAPK14|P38_PT180_Y182 0.00192783278417958 -0.37312537966211 0.00492378913797217 5 FASN|FASN 7.75744197501717e-06 -0.393437149149399 3.49084888875773e-05 5 SRC|SRC_PY527 0.00405019540933868 -0.410401629463778 0.00933520649225622 5 EGFR|EGFR_PY1068 1.55791806903759e-07 -0.436965610221569 1.01171175732442e-06 5 RICTOR|RICTOR 0.000147236672829224 -0.788703883821624 0.000488205809907427 5