Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
FOXA2 and FOXA3 transcription factor networks	63.0	2923.0	46.0	-1.249	0.019	1000.0	-1000.0	-0.13	-1000.0
Ephrin A  reverse signaling	51.0	360.0	7.0	-0.231	0.004	1000.0	-1000.0	-0.032	-1000.0
Syndecan-1-mediated signaling events	41.0	1397.0	34.0	-0.39	0.012	1000.0	-1000.0	-0.077	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	38.0	3025.0	78.0	-0.452	0.153	1000.0	-1000.0	-0.094	-1000.0
Signaling events mediated by the Hedgehog family	32.0	1685.0	52.0	-0.348	0.2	1000.0	-1000.0	-0.086	-1000.0
Osteopontin-mediated events	31.0	1192.0	38.0	-0.437	0.014	1000.0	-1000.0	-0.124	-1000.0
IL23-mediated signaling events	31.0	1888.0	60.0	-0.632	0.012	1000.0	-1000.0	-0.203	-1000.0
TCGA08_retinoblastoma	30.0	240.0	8.0	-0.157	0.053	1000.0	-1000.0	-0.028	-1000.0
Ephrin B reverse signaling	24.0	1193.0	48.0	-0.233	0.217	1000.0	-1000.0	-0.076	-1000.0
Aurora B signaling	24.0	1619.0	67.0	-0.353	0.012	1000.0	-1000.0	-0.082	-1000.0
Glucocorticoid receptor regulatory network	21.0	2504.0	114.0	-0.767	0.377	1000.0	-1000.0	-0.073	-1000.0
Glypican 2 network	20.0	81.0	4.0	-0.092	-1000.0	1000.0	-1000.0	-0.039	-1000.0
Glypican 1 network	19.0	914.0	48.0	-0.27	0.031	1000.0	-1000.0	-0.057	-1000.0
S1P5 pathway	19.0	337.0	17.0	-0.381	0.152	1000.0	-1000.0	-0.064	-1000.0
LPA receptor mediated events	19.0	1968.0	102.0	-0.417	0.036	1000.0	-1000.0	-0.106	-1000.0
FOXM1 transcription factor network	19.0	999.0	51.0	-0.34	0.021	1000.0	-1000.0	-0.23	-1000.0
EPHB forward signaling	18.0	1568.0	85.0	-0.239	0.18	1000.0	-1000.0	-0.106	-1000.0
Effects of Botulinum toxin	18.0	477.0	26.0	-0.372	0.015	1000.0	-1000.0	-0.073	-1000.0
Reelin signaling pathway	17.0	960.0	56.0	-0.268	0.012	1000.0	-1000.0	-0.087	-1000.0
Syndecan-2-mediated signaling events	15.0	1070.0	69.0	-0.502	0.043	1000.0	-1000.0	-0.066	-1000.0
IL4-mediated signaling events	14.0	1337.0	91.0	-0.782	0.507	1000.0	-1000.0	-0.201	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	13.0	709.0	54.0	-0.234	0.026	1000.0	-1000.0	-0.113	-1000.0
p75(NTR)-mediated signaling	13.0	1643.0	125.0	-0.519	0.012	1000.0	-1000.0	-0.121	-1000.0
Nectin adhesion pathway	13.0	866.0	63.0	-0.467	0.024	1000.0	-1000.0	-0.088	-1000.0
Wnt signaling	13.0	92.0	7.0	-0.211	0.012	1000.0	-1000.0	-0.031	-1000.0
amb2 Integrin signaling	12.0	1040.0	82.0	-0.282	0.012	1000.0	-1000.0	-0.102	-1000.0
IL1-mediated signaling events	12.0	765.0	62.0	-0.385	0.062	1000.0	-1000.0	-0.108	-1000.0
TCGA08_p53	12.0	88.0	7.0	-0.116	0.055	1000.0	-1000.0	-0.021	-1000.0
Syndecan-3-mediated signaling events	12.0	440.0	35.0	-0.502	0.012	1000.0	-1000.0	-0.071	-1000.0
S1P4 pathway	12.0	301.0	25.0	-0.381	0.021	1000.0	-1000.0	-0.065	-1000.0
Sphingosine 1-phosphate (S1P) pathway	11.0	329.0	28.0	-0.381	0.016	1000.0	-1000.0	-0.063	-1000.0
Signaling events regulated by Ret tyrosine kinase	11.0	936.0	82.0	-0.227	0.012	1000.0	-1000.0	-0.102	-1000.0
Endothelins	11.0	1091.0	96.0	-0.325	0.108	1000.0	-1000.0	-0.101	-1000.0
Aurora C signaling	10.0	74.0	7.0	-0.139	0.003	1000.0	-1000.0	-0.046	-1000.0
PLK1 signaling events	10.0	857.0	85.0	-0.269	0.014	1000.0	-1000.0	-0.061	-1000.0
Canonical Wnt signaling pathway	10.0	549.0	51.0	-0.321	0.071	1000.0	-1000.0	-0.067	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	10.0	722.0	68.0	-0.549	0.032	1000.0	-1000.0	-0.148	-1000.0
EGFR-dependent Endothelin signaling events	10.0	228.0	21.0	-0.113	0.012	1000.0	-1000.0	-0.08	-1000.0
E-cadherin signaling events	10.0	54.0	5.0	-0.096	0.012	1000.0	-1000.0	-0.048	-1000.0
LPA4-mediated signaling events	9.0	118.0	12.0	-0.064	0.02	1000.0	-1000.0	-0.028	-1000.0
Coregulation of Androgen receptor activity	9.0	712.0	76.0	-0.4	0.024	1000.0	-1000.0	-0.063	-1000.0
ErbB4 signaling events	9.0	669.0	69.0	-0.243	0.148	1000.0	-1000.0	-0.099	-1000.0
Visual signal transduction: Cones	9.0	362.0	38.0	-0.176	0.014	1000.0	-1000.0	-0.076	-1000.0
Signaling events mediated by PTP1B	9.0	732.0	76.0	-0.291	0.047	1000.0	-1000.0	-0.099	-1000.0
Aurora A signaling	9.0	572.0	60.0	-0.291	0.045	1000.0	-1000.0	-0.08	-1000.0
BMP receptor signaling	9.0	758.0	81.0	-0.237	0.036	1000.0	-1000.0	-0.1	-1000.0
Nongenotropic Androgen signaling	9.0	491.0	52.0	-0.139	0.012	1000.0	-1000.0	-0.067	-1000.0
Syndecan-4-mediated signaling events	9.0	666.0	67.0	-0.372	0.034	1000.0	-1000.0	-0.1	-1000.0
Visual signal transduction: Rods	9.0	479.0	52.0	-0.248	0.012	1000.0	-1000.0	-0.097	-1000.0
Noncanonical Wnt signaling pathway	8.0	208.0	26.0	-0.211	0.012	1000.0	-1000.0	-0.086	-1000.0
Presenilin action in Notch and Wnt signaling	8.0	505.0	61.0	-0.321	0.034	1000.0	-1000.0	-0.078	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	8.0	1060.0	120.0	-0.41	0.112	1000.0	-1000.0	-0.084	-1000.0
EPO signaling pathway	7.0	392.0	55.0	-0.123	0.027	1000.0	-1000.0	-0.105	-1000.0
TRAIL signaling pathway	7.0	356.0	48.0	-0.056	0.028	1000.0	-1000.0	-0.079	-1000.0
Signaling mediated by p38-alpha and p38-beta	7.0	349.0	44.0	-0.202	0.012	1000.0	-1000.0	-0.059	-1000.0
Integrins in angiogenesis	7.0	612.0	84.0	-0.437	0.037	1000.0	-1000.0	-0.122	-1000.0
Calcium signaling in the CD4+ TCR pathway	7.0	247.0	31.0	-0.277	0.013	1000.0	-1000.0	-0.099	-1000.0
IL12-mediated signaling events	6.0	595.0	87.0	-0.216	0.027	1000.0	-1000.0	-0.16	-1000.0
HIF-1-alpha transcription factor network	6.0	488.0	76.0	-0.319	0.042	1000.0	-1000.0	-0.209	-1000.0
Arf6 signaling events	6.0	420.0	62.0	-0.238	0.021	1000.0	-1000.0	-0.082	-1000.0
Fc-epsilon receptor I signaling in mast cells	6.0	596.0	97.0	-0.1	0.028	1000.0	-1000.0	-0.108	-1000.0
Regulation of Androgen receptor activity	6.0	470.0	70.0	-0.56	0.026	1000.0	-1000.0	-0.076	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	5.0	190.0	34.0	-0.033	0.021	1000.0	-1000.0	-0.071	-1000.0
IL2 signaling events mediated by PI3K	5.0	315.0	58.0	-0.147	0.053	1000.0	-1000.0	-0.102	-1000.0
BCR signaling pathway	5.0	592.0	99.0	-0.098	0.03	1000.0	-1000.0	-0.1	-1000.0
ErbB2/ErbB3 signaling events	4.0	311.0	65.0	-0.155	0.025	1000.0	-1000.0	-0.079	-1000.0
Caspase cascade in apoptosis	4.0	331.0	74.0	-0.187	0.025	1000.0	-1000.0	-0.066	-1000.0
PLK2 and PLK4 events	4.0	12.0	3.0	-0.014	0.002	1000.0	-1000.0	-0.023	-1000.0
Thromboxane A2 receptor signaling	4.0	488.0	105.0	-0.238	0.04	1000.0	-1000.0	-0.088	-1000.0
IFN-gamma pathway	4.0	289.0	68.0	-0.129	0.036	1000.0	-1000.0	-0.109	-1000.0
TCR signaling in naïve CD8+ T cells	4.0	422.0	93.0	-0.184	0.106	1000.0	-1000.0	-0.101	-1000.0
IL27-mediated signaling events	4.0	254.0	51.0	-0.106	0.012	1000.0	-1000.0	-0.087	-1000.0
Plasma membrane estrogen receptor signaling	4.0	348.0	86.0	-0.238	0.04	1000.0	-1000.0	-0.095	-1000.0
Angiopoietin receptor Tie2-mediated signaling	4.0	411.0	88.0	-0.127	0.053	1000.0	-1000.0	-0.112	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	4.0	161.0	33.0	-0.222	0.038	1000.0	-1000.0	-0.076	-1000.0
Regulation of nuclear SMAD2/3 signaling	3.0	459.0	136.0	-0.216	0.079	1000.0	-1000.0	-0.092	-1000.0
BARD1 signaling events	3.0	213.0	57.0	-0.277	0.039	1000.0	-1000.0	-0.085	-1000.0
Hedgehog signaling events mediated by Gli proteins	3.0	218.0	65.0	-0.438	0.07	1000.0	-1000.0	-0.076	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	3.0	140.0	37.0	-0.148	0.044	1000.0	-1000.0	-0.065	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	3.0	185.0	52.0	-0.079	0.02	1000.0	-1000.0	-0.079	-1000.0
S1P1 pathway	3.0	108.0	36.0	-0.096	0.018	1000.0	-1000.0	-0.068	-1000.0
Retinoic acid receptors-mediated signaling	3.0	190.0	58.0	-0.1	0.029	1000.0	-1000.0	-0.088	-1000.0
Regulation of p38-alpha and p38-beta	3.0	183.0	54.0	-0.194	0.012	1000.0	-1000.0	-0.068	-1000.0
IL6-mediated signaling events	3.0	252.0	75.0	-0.341	0.06	1000.0	-1000.0	-0.12	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	3.0	233.0	74.0	-0.123	0.061	1000.0	-1000.0	-0.105	-1000.0
VEGFR1 specific signals	3.0	214.0	56.0	-0.1	0.04	1000.0	-1000.0	-0.088	-1000.0
S1P3 pathway	3.0	164.0	42.0	-0.238	0.027	1000.0	-1000.0	-0.073	-1000.0
Canonical NF-kappaB pathway	2.0	115.0	39.0	-0.139	0.07	1000.0	-1000.0	-0.107	-1000.0
JNK signaling in the CD4+ TCR pathway	2.0	38.0	17.0	-0.022	0.04	1000.0	-1000.0	-0.077	-1000.0
Insulin-mediated glucose transport	2.0	71.0	32.0	-0.267	0.032	1000.0	-1000.0	-0.08	-1000.0
Ceramide signaling pathway	2.0	224.0	76.0	-0.139	0.023	1000.0	-1000.0	-0.074	-1000.0
Signaling events mediated by HDAC Class III	2.0	111.0	40.0	-0.093	0.023	1000.0	-1000.0	-0.046	-1000.0
Signaling mediated by p38-gamma and p38-delta	2.0	37.0	15.0	-0.005	0.029	1000.0	-1000.0	-0.035	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	2.0	103.0	45.0	-0.139	0.071	1000.0	-1000.0	-0.103	-1000.0
E-cadherin signaling in the nascent adherens junction	2.0	205.0	76.0	-0.096	0.058	1000.0	-1000.0	-0.104	-1000.0
IL2 signaling events mediated by STAT5	2.0	54.0	22.0	-0.052	0.051	1000.0	-1000.0	-0.079	-1000.0
Class I PI3K signaling events	2.0	174.0	73.0	-0.184	0.033	1000.0	-1000.0	-0.094	-1000.0
Regulation of Telomerase	2.0	256.0	102.0	-0.15	0.048	1000.0	-1000.0	-0.124	-1000.0
Signaling events mediated by PRL	2.0	75.0	34.0	-0.08	0.041	1000.0	-1000.0	-0.049	-1000.0
Cellular roles of Anthrax toxin	1.0	63.0	39.0	-0.139	0.02	1000.0	-1000.0	-0.038	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	1.0	122.0	85.0	-0.024	0.054	1000.0	-1000.0	-0.088	-1000.0
PDGFR-alpha signaling pathway	1.0	70.0	44.0	-0.018	0.036	1000.0	-1000.0	-0.064	-1000.0
Class I PI3K signaling events mediated by Akt	1.0	68.0	68.0	-0.267	0.049	1000.0	-1000.0	-0.076	-1000.0
ceramide signaling pathway	1.0	83.0	49.0	-0.138	0.03	1000.0	-1000.0	-0.06	-1000.0
HIF-2-alpha transcription factor network	1.0	66.0	43.0	-0.079	0.08	1000.0	-1000.0	-0.117	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	1.0	119.0	83.0	-0.267	0.06	1000.0	-1000.0	-0.098	-1000.0
Signaling events mediated by HDAC Class I	1.0	175.0	104.0	-0.139	0.057	1000.0	-1000.0	-0.069	-1000.0
FoxO family signaling	1.0	91.0	64.0	-0.267	0.125	1000.0	-1000.0	-0.106	-1000.0
FAS signaling pathway (CD95)	1.0	89.0	47.0	-0.042	0.031	1000.0	-1000.0	-0.056	-1000.0
TCGA08_rtk_signaling	1.0	26.0	26.0	-0.036	0.047	1000.0	-1000.0	-0.026	-1000.0
IGF1 pathway	1.0	107.0	57.0	-0.039	0.037	1000.0	-1000.0	-0.116	-1000.0
Insulin Pathway	1.0	75.0	74.0	-0.054	0.039	1000.0	-1000.0	-0.111	-1000.0
PDGFR-beta signaling pathway	1.0	134.0	97.0	-0.19	0.064	1000.0	-1000.0	-0.1	-1000.0
E-cadherin signaling in keratinocytes	1.0	81.0	43.0	-0.096	0.024	1000.0	-1000.0	-0.08	-1000.0
Ras signaling in the CD4+ TCR pathway	1.0	33.0	17.0	-0.011	0.046	1000.0	-1000.0	-0.051	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	0.0	23.0	0.0	0.046	1000.0	-1000.0	-0.082	-1000.0
Signaling events mediated by HDAC Class II	0.0	25.0	75.0	-0.013	0.034	1000.0	-1000.0	-0.07	-1000.0
Circadian rhythm pathway	0.0	5.0	22.0	-0.014	0.052	1000.0	-1000.0	-0.067	-1000.0
a4b1 and a4b7 Integrin signaling	0.0	0.0	5.0	0.0	0.012	1000.0	-1000.0	-0.041	-1000.0
Arf6 downstream pathway	0.0	30.0	43.0	-0.028	0.028	1000.0	-1000.0	-0.05	-1000.0
mTOR signaling pathway	0.0	0.0	53.0	-0.0	0.034	1000.0	-1000.0	-0.073	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	8.0	36.0	-0.007	0.023	1000.0	-1000.0	-0.085	-1000.0
Atypical NF-kappaB pathway	0.0	11.0	31.0	-0.031	0.039	1000.0	-1000.0	-0.063	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	0.0	98.0	125.0	-0.027	0.093	1000.0	-1000.0	-0.124	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	6.0	27.0	-0.005	0.029	1000.0	-1000.0	-0.064	-1000.0
Arf6 trafficking events	0.0	69.0	71.0	-0.126	0.043	1000.0	-1000.0	-0.088	-1000.0
Rapid glucocorticoid signaling	0.0	9.0	20.0	-0.004	0.012	1000.0	-1000.0	-0.049	-1000.0
Class IB PI3K non-lipid kinase events	0.0	0.0	3.0	-0.012	0.012	1000.0	-1000.0	-0.02	-1000.0
p38 MAPK signaling pathway	0.0	42.0	44.0	-0.081	0.036	1000.0	-1000.0	-0.078	-1000.0
Arf1 pathway	0.0	4.0	54.0	-0.006	0.033	1000.0	-1000.0	-0.046	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	-0.0	0.012	1000.0	-1000.0	-0.07	-1000.0
Total	1079	60233	7203	-28.1126298404	-993.763305715	131000	-131000	-11.0352898655	-131000