GSEA Class2: Canonical Pathways enriched in each subtypes of mRNAseq_cNMF in UCS-TP

Uterine Carcinosarcoma (Primary solid tumor)

28 January 2016 | analyses__2016_01_28

Maintainer Information

Citation Information

Maintained by Juok Cho (Broad Institute)

Cite as Broad Institute TCGA Genome Data Analysis Center (2016): GSEA Class2: Canonical Pathways enriched in each subtypes of mRNAseq_cNMF in UCS-TP. Broad Institute of MIT and Harvard. doi:10.7908/C11N80NG

+ Overview

+ Introduction

+ Summary

Table 1. Get Full Table basic data info

basic data info
Number of Gene Sets: 723
Number of samples: 57
Original number of Gene Sets: 1320
Maximum gene set size: 933

Table 2. Get Full Table pheno data info

phenotype info
pheno.type: 1 - 4 :[ clus1 ] 16
pheno.type: 2 - 4 :[ clus2 ] 19
pheno.type: 3 - 4 :[ clus3 ] 12
pheno.type: 4 - 4 :[ clus4 ] 10

For the expression subtypes of 18665 genes in 58 samples, GSEA found enriched gene sets in each cluster using 57 gene sets in MSigDB canonical pathways. Top enriched gene sets are listed as below.

clus1

Top enriched gene sets are KEGG AMINOACYL TRNA BIOSYNTHESIS, KEGG RNA DEGRADATION, KEGG CARDIAC MUSCLE CONTRACTION, KEGG PARKINSONS DISEASE, BIOCARTA NO1 PATHWAY, BIOCARTA INTEGRIN PATHWAY, BIOCARTA CHREBP2 PATHWAY, PID HDAC CLASSIII PATHWAY, PID RB 1PATHWAY, REACTOME RNA POL II TRANSCRIPTION

And common core enriched genes are ACTA1, ACTN2, ACTN3, EIF4EBP1, PRKAA2, PRKAB2, PRKAG3, STRADB, ASB1, ASB12

clus2

Top enriched gene sets are KEGG TOLL LIKE RECEPTOR SIGNALING PATHWAY, BIOCARTA FAS PATHWAY, PID HIF2PATHWAY, PID AVB3 OPN PATHWAY, PID TRAIL PATHWAY, PID FASPATHWAY, PID IL1PATHWAY, PID ECADHERIN NASCENTAJ PATHWAY, PID PDGFRBPATHWAY, PID TAP63PATHWAY

And common core enriched genes are MAP3K1, PIK3R1, CASP10, CASP8, CFLAR, PIK3CB, PIK3R3, MAP2K6, MAPK10, SYK

clus3

Top enriched gene sets are KEGG SELENOAMINO ACID METABOLISM, KEGG STARCH AND SUCROSE METABOLISM, KEGG BUTANOATE METABOLISM, KEGG RETINOL METABOLISM, KEGG PORPHYRIN AND CHLOROPHYLL METABOLISM, KEGG METABOLISM OF XENOBIOTICS BY CYTOCHROME P450, KEGG DRUG METABOLISM CYTOCHROME P450, SIG IL4RECEPTOR IN B LYPHOCYTES, ST INTERLEUKIN 4 PATHWAY, PID CD40 PATHWAY

And common core enriched genes are UGT1A6, UGT1A9, UGT2B10, UGT2B11, UGT2B7, UGT2A3, UGT2B15, GSTO2, IRS2, JAK3

clus4

Top enriched gene sets are KEGG CELL CYCLE, ST WNT BETA CATENIN PATHWAY, PID AURORA B PATHWAY, PID PLK1 PATHWAY, PID FOXM1PATHWAY, PID AURORA A PATHWAY, REACTOME MEIOSIS, REACTOME CELL CYCLE, REACTOME SIGNALLING TO ERKS, REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS

And common core enriched genes are AURKA, BIRC5, CDC25B, CENPA, CKAP5, PPP2R5D, BUB1, CDC20, ERCC6L, INCENP

+ Results

+ Subtype clus1 enriched pathways

Table 3. Get Full Table This table shows top 10 pathways which are significantly enriched in cluster clus1. It displays only significant gene sets satisfying nom.p.val.threshold (-1), fwer.p.val.threshold (-1) , fdr.q.val.threshold (0.25) and the default table is sorted by Normalized Enrichment Score (NES). Further details on NES statistics, please visit The Broad GSEA website.

GeneSet(GS)	Size(#genes)	genes.ES.table	ES	NES	NOM.p.val	FDR.q.val	FWER.p.val	Tag..	Gene..	Signal	FDR..median.	glob.p.val
KEGG AMINOACYL TRNA BIOSYNTHESIS	41	genes.ES.table	0.47	1.7	0.045	0.35	0.71	0.61	0.37	0.39	0.12	0.095
KEGG RNA DEGRADATION	57	genes.ES.table	0.37	1.8	0.034	0.39	0.7	0.018	0.0024	0.018	0.13	0.1
KEGG CARDIAC MUSCLE CONTRACTION	70	genes.ES.table	0.71	1.9	0	0.42	0.39	0.29	0.046	0.27	0	0.08
KEGG PARKINSONS DISEASE	112	genes.ES.table	0.44	1.7	0.054	0.33	0.76	0.53	0.33	0.36	0.12	0.09
BIOCARTA NO1 PATHWAY	29	genes.ES.table	0.69	1.7	0.002	0.34	0.74	0.21	0.038	0.2	0.12	0.091
BIOCARTA INTEGRIN PATHWAY	38	genes.ES.table	0.58	2.1	0	0.2	0.064	0.079	0.0061	0.079	0	0.043
BIOCARTA CHREBP2 PATHWAY	41	genes.ES.table	0.45	1.7	0.0021	0.36	0.7	0.22	0.16	0.19	0.12	0.095
PID HDAC CLASSIII PATHWAY	25	genes.ES.table	0.61	1.9	0.0058	0.36	0.41	0.4	0.16	0.34	0	0.076
PID RB 1PATHWAY	65	genes.ES.table	0.48	1.8	0	0.32	0.48	0.17	0.093	0.15	0	0.069
REACTOME RNA POL II TRANSCRIPTION	93	genes.ES.table	0.38	1.8	0.051	0.34	0.64	0.5	0.37	0.31	0.098	0.089

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	ACTN2	ACTN2	ACTN2	23	1.5	0.22	YES
2	ACTA1	ACTA1	ACTA1	31	1.4	0.43	YES
3	ACTN3	ACTN3	ACTN3	113	1.1	0.58	YES
4	PPP1R12B	PPP1R12B	PPP1R12B	1688	0.23	0.53	NO
5	FYN	FYN	FYN	1971	0.2	0.55	NO
6	MAP2K1	MAP2K1	MAP2K1	2391	0.17	0.55	NO
7	HRAS	HRAS	HRAS	3248	0.12	0.52	NO
8	PXN	PXN	PXN	3495	0.11	0.52	NO
9	RAPGEF1	RAPGEF1	RAPGEF1	3521	0.11	0.54	NO
10	TNS1	TNS1	TNS1	4642	0.073	0.49	NO
11	MAP2K2	MAP2K2	MAP2K2	5930	0.047	0.43	NO
12	CRKL	CRKL	CRKL	6664	0.035	0.39	NO
13	SHC1	SHC1	SHC1	6711	0.034	0.4	NO
14	RAF1	RAF1	RAF1	6814	0.032	0.39	NO
15	MAPK8	MAPK8	MAPK8	6914	0.03	0.39	NO
16	ZYX	ZYX	ZYX	7465	0.022	0.37	NO
17	RAP1A	RAP1A	RAP1A	7725	0.018	0.36	NO
18	MAPK1	MAPK1	MAPK1	7853	0.016	0.35	NO
19	CSK	CSK	CSK	8559	0.0048	0.31	NO
20	RHOA	RHOA	RHOA	8652	0.003	0.31	NO
21	CAV1	CAV1	CAV1	9672	-0.013	0.26	NO
22	SRC	SRC	SRC	9947	-0.018	0.24	NO
23	GRB2	GRB2	GRB2	9989	-0.018	0.24	NO
24	SOS1	SOS1	SOS1	10077	-0.02	0.24	NO
25	CAPNS1	CAPNS1	CAPNS1	10250	-0.023	0.24	NO
26	BCAR1	BCAR1	BCAR1	10424	-0.025	0.23	NO
27	PTK2	PTK2	PTK2	11049	-0.036	0.2	NO
28	TLN1	TLN1	TLN1	11181	-0.039	0.2	NO
29	VCL	VCL	VCL	11359	-0.042	0.2	NO
30	ITGB1	ITGB1	ITGB1	12455	-0.064	0.15	NO
31	MAPK3	MAPK3	MAPK3	12657	-0.069	0.15	NO
32	ROCK1	ROCK1	ROCK1	12951	-0.076	0.14	NO
33	CAPN1	CAPN1	CAPN1	13736	-0.097	0.12	NO
34	ACTN1	ACTN1	ACTN1	14166	-0.11	0.11	NO
35	JUN	JUN	JUN	14534	-0.12	0.11	NO
36	ITGA1	ITGA1	ITGA1	14927	-0.14	0.11	NO
37	BCR	BCR	BCR	15371	-0.16	0.11	NO
38	CAPNS2	CAPNS2	CAPNS2	18090	-0.45	0.03	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	PRKAG3	PRKAG3	PRKAG3	27	1.4	0.42	YES
2	PRKAA2	PRKAA2	PRKAA2	1096	0.33	0.46	YES
3	STRADB	STRADB	STRADB	2185	0.19	0.46	YES
4	PRKAB2	PRKAB2	PRKAB2	2730	0.14	0.47	YES
5	EIF4EBP1	EIF4EBP1	EIF4EBP1	2747	0.14	0.51	YES
6	EEF2K	EEF2K	EEF2K	4692	0.072	0.43	NO
7	PRKAG1	PRKAG1	PRKAG1	5610	0.053	0.4	NO
8	STK11	STK11	STK11	5768	0.05	0.4	NO
9	AKT2	AKT2	AKT2	5822	0.049	0.41	NO
10	EIF4G1	EIF4G1	EIF4G1	5845	0.049	0.43	NO
11	RPS6	RPS6	RPS6	5981	0.046	0.43	NO
12	RPTOR	RPTOR	RPTOR	6051	0.046	0.44	NO
13	EIF4B	EIF4B	EIF4B	6358	0.04	0.44	NO
14	CAB39	CAB39	CAB39	6611	0.036	0.44	NO
15	PDE3B	PDE3B	PDE3B	6683	0.034	0.44	NO
16	RPS6KB1	RPS6KB1	RPS6KB1	7054	0.028	0.43	NO
17	TSC1	TSC1	TSC1	7593	0.019	0.41	NO
18	TSC2	TSC2	TSC2	8118	0.012	0.38	NO
19	MLST8	MLST8	MLST8	8373	0.0077	0.37	NO
20	RHEB	RHEB	RHEB	9726	-0.014	0.3	NO
21	MTOR	MTOR	MTOR	10160	-0.021	0.29	NO
22	PPM1A	PPM1A	PPM1A	10748	-0.031	0.26	NO
23	STRADA	STRADA	STRADA	10998	-0.035	0.26	NO
24	PRKAB1	PRKAB1	PRKAB1	12307	-0.061	0.21	NO
25	PRKAA1	PRKAA1	PRKAA1	12425	-0.064	0.22	NO
26	EIF4E	EIF4E	EIF4E	12852	-0.074	0.22	NO
27	CAB39L	CAB39L	CAB39L	14406	-0.12	0.17	NO
28	PRKAG2	PRKAG2	PRKAG2	15964	-0.19	0.14	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	ASB4	ASB4	ASB4	50	1.3	0.07	YES
2	ASB5	ASB5	ASB5	60	1.3	0.14	YES
3	TRIM63	TRIM63	TRIM63	66	1.2	0.21	YES
4	SPSB4	SPSB4	SPSB4	237	0.73	0.24	YES
5	ASB2	ASB2	ASB2	468	0.53	0.26	YES
6	ZBTB16	ZBTB16	ZBTB16	506	0.51	0.28	YES
7	ASB16	ASB16	ASB16	1004	0.34	0.28	YES
8	SKP2	SKP2	SKP2	1050	0.34	0.29	YES
9	KLHL13	KLHL13	KLHL13	1322	0.28	0.29	YES
10	DET1	DET1	DET1	1338	0.28	0.31	YES
11	ASB12	ASB12	ASB12	1619	0.24	0.31	YES
12	FBXO17	FBXO17	FBXO17	2211	0.18	0.28	YES
13	TCEB1	TCEB1	TCEB1	2440	0.16	0.28	YES
14	UBE2E2	UBE2E2	UBE2E2	2533	0.16	0.29	YES
15	BTRC	BTRC	BTRC	2833	0.14	0.28	YES
16	DZIP3	DZIP3	DZIP3	2927	0.13	0.28	YES
17	UBE2D4	UBE2D4	UBE2D4	2947	0.13	0.29	YES
18	UBE2W	UBE2W	UBE2W	2977	0.13	0.29	YES
19	CDC34	CDC34	CDC34	2993	0.13	0.3	YES
20	ASB1	ASB1	ASB1	3002	0.13	0.3	YES
21	UBE2V2	UBE2V2	UBE2V2	3102	0.12	0.31	YES
22	PSMD6	PSMD6	PSMD6	3157	0.12	0.31	YES
23	UBE2G2	UBE2G2	UBE2G2	3526	0.11	0.3	NO
24	FBXW8	FBXW8	FBXW8	3622	0.1	0.3	NO
25	RNF6	RNF6	RNF6	3716	0.1	0.3	NO
26	ANAPC13	ANAPC13	ANAPC13	3945	0.093	0.29	NO
27	PSMC4	PSMC4	PSMC4	4079	0.089	0.29	NO
28	UBE3B	UBE3B	UBE3B	4220	0.085	0.28	NO
29	PSMC1	PSMC1	PSMC1	4246	0.084	0.29	NO
30	CUL5	CUL5	CUL5	4268	0.083	0.29	NO
31	TMEM189-UBE2V1	TMEM189-UBE2V1	TMEM189-UBE2V1	4312	0.082	0.29	NO
32	UBE2E3	UBE2E3	UBE2E3	4350	0.081	0.3	NO
33	PSMC2	PSMC2	PSMC2	4591	0.075	0.29	NO
34	UBA5	UBA5	UBA5	4604	0.074	0.29	NO
35	PJA2	PJA2	PJA2	4618	0.074	0.29	NO
36	ASB8	ASB8	ASB8	4682	0.072	0.3	NO
37	STUB1	STUB1	STUB1	4707	0.072	0.3	NO
38	UBA2	UBA2	UBA2	5049	0.064	0.28	NO
39	PSME4	PSME4	PSME4	5056	0.064	0.29	NO
40	PSMD14	PSMD14	PSMD14	5112	0.063	0.29	NO
41	UBE2J2	UBE2J2	UBE2J2	5120	0.063	0.29	NO
42	PSMD4	PSMD4	PSMD4	5162	0.062	0.29	NO
43	PSMA5	PSMA5	PSMA5	5202	0.061	0.29	NO
44	UBE2M	UBE2M	UBE2M	5264	0.06	0.29	NO
45	PSMD2	PSMD2	PSMD2	5283	0.06	0.3	NO
46	TPP2	TPP2	TPP2	5348	0.058	0.29	NO
47	RPS27A	RPS27A	RPS27A	5447	0.056	0.29	NO
48	UBA52	UBA52	UBA52	5448	0.056	0.3	NO
49	PSMD1	PSMD1	PSMD1	5499	0.056	0.3	NO
50	RNF123	RNF123	RNF123	5508	0.055	0.3	NO
51	BLMH	BLMH	BLMH	5524	0.055	0.3	NO
52	TRIM36	TRIM36	TRIM36	5551	0.054	0.3	NO
53	UBE4A	UBE4A	UBE4A	5623	0.053	0.3	NO
54	CUL2	CUL2	CUL2	5655	0.052	0.3	NO
55	CUL7	CUL7	CUL7	5656	0.052	0.3	NO
56	PSMD8	PSMD8	PSMD8	5669	0.052	0.31	NO
57	FBXW11	FBXW11	FBXW11	5721	0.051	0.31	NO
58	UBE2G1	UBE2G1	UBE2G1	5774	0.05	0.31	NO
59	ANAPC7	ANAPC7	ANAPC7	5846	0.049	0.31	NO
60	UBE2B	UBE2B	UBE2B	5946	0.047	0.3	NO
61	VPRBP	VPRBP	VPRBP	6124	0.044	0.3	NO
62	PSMD12	PSMD12	PSMD12	6178	0.043	0.3	NO
63	UBE2Q2	UBE2Q2	UBE2Q2	6182	0.043	0.3	NO
64	GAN	GAN	GAN	6183	0.043	0.3	NO
65	CUL1	CUL1	CUL1	6239	0.042	0.3	NO
66	PSMD3	PSMD3	PSMD3	6267	0.042	0.3	NO
67	WSB1	WSB1	WSB1	6470	0.038	0.29	NO
68	PSMA4	PSMA4	PSMA4	6542	0.037	0.29	NO
69	PSMD11	PSMD11	PSMD11	6557	0.037	0.29	NO
70	NEDD4	NEDD4	NEDD4	6600	0.036	0.29	NO
71	UBE3A	UBE3A	UBE3A	6638	0.035	0.29	NO
72	UBR2	UBR2	UBR2	6642	0.035	0.29	NO
73	CUL3	CUL3	CUL3	6719	0.034	0.29	NO
74	UBE2C	UBE2C	UBE2C	6722	0.034	0.29	NO
75	NPEPPS	NPEPPS	NPEPPS	6726	0.034	0.3	NO
76	ANAPC11	ANAPC11	ANAPC11	6764	0.033	0.29	NO
77	PSMD10	PSMD10	PSMD10	6771	0.033	0.3	NO
78	PSMA1	PSMA1	PSMA1	6834	0.032	0.29	NO
79	UBE2F	UBE2F	UBE2F	6835	0.032	0.3	NO
80	TRIP12	TRIP12	TRIP12	6839	0.031	0.3	NO
81	UBR4	UBR4	UBR4	6962	0.029	0.29	NO
82	ASB7	ASB7	ASB7	6992	0.029	0.29	NO
83	KEAP1	KEAP1	KEAP1	6996	0.029	0.29	NO
84	PSMB2	PSMB2	PSMB2	7021	0.028	0.29	NO
85	PSMB5	PSMB5	PSMB5	7105	0.027	0.29	NO
86	ARIH2	ARIH2	ARIH2	7150	0.027	0.29	NO
87	PSMC5	PSMC5	PSMC5	7182	0.026	0.29	NO
88	UBE2R2	UBE2R2	UBE2R2	7219	0.026	0.29	NO
89	PSMA7	PSMA7	PSMA7	7244	0.025	0.29	NO
90	UBE2N	UBE2N	UBE2N	7270	0.025	0.29	NO
91	UBE2J1	UBE2J1	UBE2J1	7354	0.023	0.29	NO
92	UBE2Q1	UBE2Q1	UBE2Q1	7399	0.022	0.29	NO
93	PSMB4	PSMB4	PSMB4	7409	0.022	0.29	NO
94	HECTD3	HECTD3	HECTD3	7412	0.022	0.29	NO
95	RBX1	RBX1	RBX1	7572	0.02	0.28	NO
96	PSMB7	PSMB7	PSMB7	7606	0.019	0.28	NO
97	KLHL20	KLHL20	KLHL20	7644	0.019	0.28	NO
98	RCHY1	RCHY1	RCHY1	7666	0.018	0.28	NO
99	PSMD13	PSMD13	PSMD13	7744	0.017	0.28	NO
100	PJA1	PJA1	PJA1	7759	0.017	0.28	NO
101	CDC20	CDC20	CDC20	7849	0.016	0.27	NO
102	PSMC6	PSMC6	PSMC6	7899	0.015	0.27	NO
103	RNF41	RNF41	RNF41	8000	0.014	0.26	NO
104	PSMB3	PSMB3	PSMB3	8002	0.014	0.26	NO
105	RNF220	RNF220	RNF220	8034	0.013	0.26	NO
106	RNF4	RNF4	RNF4	8061	0.013	0.26	NO
107	PSMA2	PSMA2	PSMA2	8100	0.012	0.26	NO
108	PSMD7	PSMD7	PSMD7	8133	0.011	0.26	NO
109	PSMA6	PSMA6	PSMA6	8263	0.0093	0.26	NO
110	CDC27	CDC27	CDC27	8271	0.0092	0.26	NO
111	UBR1	UBR1	UBR1	8345	0.0081	0.25	NO
112	UBE2D3	UBE2D3	UBE2D3	8403	0.0073	0.25	NO
113	PSMB1	PSMB1	PSMB1	8421	0.007	0.25	NO
114	FBXO4	FBXO4	FBXO4	8528	0.0052	0.24	NO
115	UBE2O	UBE2O	UBE2O	8585	0.0044	0.24	NO
116	SKP1	SKP1	SKP1	8595	0.0042	0.24	NO
117	UBE2S	UBE2S	UBE2S	8664	0.0029	0.24	NO
118	TRIM32	TRIM32	TRIM32	8668	0.0029	0.24	NO
119	UBA1	UBA1	UBA1	8722	0.002	0.23	NO
120	VHL	VHL	VHL	8738	0.0018	0.23	NO
121	ANAPC5	ANAPC5	ANAPC5	8820	0.00073	0.23	NO
122	SAE1	SAE1	SAE1	8832	0.00056	0.23	NO
123	ASB13	ASB13	ASB13	8864	0.000031	0.23	NO
124	RNF25	RNF25	RNF25	9295	-0.0072	0.2	NO
125	PSMC3	PSMC3	PSMC3	9349	-0.008	0.2	NO
126	UBOX5	UBOX5	UBOX5	9397	-0.0088	0.2	NO
127	ANAPC1	ANAPC1	ANAPC1	9477	-0.0098	0.2	NO
128	PSMA3	PSMA3	PSMA3	9479	-0.0098	0.2	NO
129	CBLB	CBLB	CBLB	9505	-0.01	0.2	NO
130	CDC23	CDC23	CDC23	9545	-0.011	0.19	NO
131	PSMB6	PSMB6	PSMB6	9600	-0.012	0.19	NO
132	MKRN1	MKRN1	MKRN1	9668	-0.013	0.19	NO
133	CDC16	CDC16	CDC16	9846	-0.016	0.18	NO
134	UBE2D1	UBE2D1	UBE2D1	9870	-0.016	0.18	NO
135	TCEB2	TCEB2	TCEB2	9906	-0.017	0.18	NO
136	UBE2A	UBE2A	UBE2A	9922	-0.017	0.18	NO
137	SPSB1	SPSB1	SPSB1	10185	-0.021	0.16	NO
138	FBXW7	FBXW7	FBXW7	10246	-0.022	0.16	NO
139	PARK2	PARK2	PARK2	10278	-0.023	0.16	NO
140	UBE2D2	UBE2D2	UBE2D2	10279	-0.023	0.16	NO
141	ANAPC4	ANAPC4	ANAPC4	10372	-0.024	0.16	NO
142	PSMD9	PSMD9	PSMD9	10577	-0.028	0.15	NO
143	CDC26	CDC26	CDC26	10585	-0.028	0.15	NO
144	KLHL9	KLHL9	KLHL9	10619	-0.029	0.15	NO
145	HERC2	HERC2	HERC2	10654	-0.03	0.15	NO
146	UBE2L3	UBE2L3	UBE2L3	10674	-0.03	0.15	NO
147	RNF182	RNF182	RNF182	10679	-0.03	0.15	NO
148	UBE2E1	UBE2E1	UBE2E1	10743	-0.031	0.15	NO
149	PSMD5	PSMD5	PSMD5	10751	-0.031	0.15	NO
150	UBE2K	UBE2K	UBE2K	10815	-0.032	0.15	NO
151	UBE2L6	UBE2L6	UBE2L6	11127	-0.038	0.14	NO
152	ASB3	ASB3	ASB3	11208	-0.039	0.14	NO
153	ANAPC10	ANAPC10	ANAPC10	11499	-0.045	0.12	NO
154	UBA7	UBA7	UBA7	11512	-0.045	0.12	NO
155	PSME1	PSME1	PSME1	11790	-0.051	0.11	NO
156	RNF138	RNF138	RNF138	11821	-0.051	0.11	NO
157	ASB6	ASB6	ASB6	11934	-0.053	0.11	NO
158	PSMF1	PSMF1	PSMF1	12011	-0.055	0.11	NO
159	TRIM9	TRIM9	TRIM9	12033	-0.055	0.11	NO
160	UBA3	UBA3	UBA3	12039	-0.055	0.11	NO
161	FBXO6	FBXO6	FBXO6	12043	-0.055	0.12	NO
162	SPSB2	SPSB2	SPSB2	12078	-0.056	0.12	NO
163	RNF34	RNF34	RNF34	12171	-0.058	0.12	NO
164	SOCS3	SOCS3	SOCS3	12250	-0.06	0.12	NO
165	UBE2Z	UBE2Z	UBE2Z	12375	-0.063	0.11	NO
166	ANAPC2	ANAPC2	ANAPC2	12541	-0.066	0.11	NO
167	HUWE1	HUWE1	HUWE1	12680	-0.07	0.1	NO
168	ATG7	ATG7	ATG7	12681	-0.07	0.11	NO
169	FBXO3	FBXO3	FBXO3	12778	-0.072	0.1	NO
170	PSMB10	PSMB10	PSMB10	12884	-0.074	0.1	NO
171	FBXO44	FBXO44	FBXO44	12978	-0.077	0.1	NO
172	TRIM11	TRIM11	TRIM11	13040	-0.078	0.1	NO
173	PSME2	PSME2	PSME2	13170	-0.081	0.1	NO
174	LRSAM1	LRSAM1	LRSAM1	13271	-0.084	0.1	NO
175	UBA6	UBA6	UBA6	13326	-0.086	0.1	NO
176	TRIM37	TRIM37	TRIM37	13467	-0.09	0.1	NO
177	RBCK1	RBCK1	RBCK1	13598	-0.094	0.098	NO
178	UBE3C	UBE3C	UBE3C	13649	-0.095	0.1	NO
179	SMURF2	SMURF2	SMURF2	13919	-0.1	0.092	NO
180	SMURF1	SMURF1	SMURF1	14078	-0.11	0.089	NO
181	DTX3L	DTX3L	DTX3L	14083	-0.11	0.095	NO
182	WWP1	WWP1	WWP1	14225	-0.11	0.094	NO
183	FBXO27	FBXO27	FBXO27	14260	-0.11	0.098	NO
184	UBE2H	UBE2H	UBE2H	14587	-0.12	0.087	NO
185	FBXO2	FBXO2	FBXO2	14983	-0.14	0.074	NO
186	LNPEP	LNPEP	LNPEP	15478	-0.16	0.056	NO
187	SOCS1	SOCS1	SOCS1	15553	-0.17	0.061	NO
188	LRRC41	LRRC41	LRRC41	15821	-0.18	0.057	NO
189	PSMB9	PSMB9	PSMB9	15858	-0.19	0.066	NO
190	PSMB8	PSMB8	PSMB8	16604	-0.24	0.038	NO
191	TRIM21	TRIM21	TRIM21	16731	-0.25	0.045	NO
192	ASB9	ASB9	ASB9	16939	-0.26	0.049	NO
193	RNF144B	RNF144B	RNF144B	17197	-0.29	0.051	NO
194	UBE2U	UBE2U	UBE2U	18211	-0.49	0.024	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	ACTC1	ACTC1	ACTC1	8	1.6	0.071	YES
2	CACNA1S	CACNA1S	CACNA1S	19	1.5	0.14	YES
3	CACNG1	CACNG1	CACNG1	47	1.3	0.19	YES
4	TNNC1	TNNC1	TNNC1	63	1.3	0.25	YES
5	ATP1B4	ATP1B4	ATP1B4	81	1.2	0.3	YES
6	COX6A2	COX6A2	COX6A2	93	1.1	0.35	YES
7	MYH7	MYH7	MYH7	98	1.1	0.4	YES
8	TNNT2	TNNT2	TNNT2	102	1.1	0.44	YES
9	MYL3	MYL3	MYL3	163	0.89	0.48	YES
10	MYH6	MYH6	MYH6	166	0.88	0.52	YES
11	MYL2	MYL2	MYL2	176	0.86	0.56	YES
12	CACNG6	CACNG6	CACNG6	276	0.7	0.58	YES
13	CACNB1	CACNB1	CACNB1	415	0.57	0.6	YES
14	RYR2	RYR2	RYR2	513	0.51	0.62	YES
15	CACNA2D1	CACNA2D1	CACNA2D1	571	0.48	0.64	YES
16	ATP1A3	ATP1A3	ATP1A3	604	0.46	0.66	YES
17	TPM2	TPM2	TPM2	698	0.43	0.67	YES
18	ATP1B2	ATP1B2	ATP1B2	705	0.42	0.69	YES
19	CACNA2D4	CACNA2D4	CACNA2D4	758	0.41	0.7	YES
20	TNNI3	TNNI3	TNNI3	858	0.38	0.71	YES
21	COX8C	COX8C	COX8C	1378	0.28	0.7	NO
22	ATP1A4	ATP1A4	ATP1A4	1401	0.27	0.71	NO
23	ATP2A2	ATP2A2	ATP2A2	1744	0.23	0.7	NO
24	ATP1A2	ATP1A2	ATP1A2	1969	0.2	0.7	NO
25	TPM1	TPM1	TPM1	2323	0.17	0.69	NO
26	UQCRFS1	UQCRFS1	UQCRFS1	2723	0.14	0.67	NO
27	CACNG8	CACNG8	CACNG8	2960	0.13	0.66	NO
28	COX7A1	COX7A1	COX7A1	3115	0.12	0.66	NO
29	UQCRC2	UQCRC2	UQCRC2	3154	0.12	0.66	NO
30	CACNA2D2	CACNA2D2	CACNA2D2	3597	0.1	0.65	NO
31	COX5A	COX5A	COX5A	3727	0.1	0.64	NO
32	COX5B	COX5B	COX5B	4073	0.089	0.63	NO
33	CYC1	CYC1	CYC1	4210	0.085	0.62	NO
34	UQCR11	UQCR11	UQCR11	4534	0.076	0.61	NO
35	COX6B1	COX6B1	COX6B1	4689	0.072	0.61	NO
36	TPM3	TPM3	TPM3	4780	0.07	0.6	NO
37	COX6C	COX6C	COX6C	4996	0.066	0.6	NO
38	COX7A2L	COX7A2L	COX7A2L	5278	0.06	0.58	NO
39	COX7B	COX7B	COX7B	5737	0.051	0.56	NO
40	COX8A	COX8A	COX8A	6045	0.046	0.55	NO
41	COX7A2	COX7A2	COX7A2	6054	0.045	0.55	NO
42	ATP1B3	ATP1B3	ATP1B3	6103	0.045	0.55	NO
43	UQCR10	UQCR10	UQCR10	6398	0.039	0.53	NO
44	COX4I1	COX4I1	COX4I1	6575	0.036	0.52	NO
45	UQCRB	UQCRB	UQCRB	6605	0.036	0.52	NO
46	CACNB4	CACNB4	CACNB4	6944	0.03	0.51	NO
47	CACNB2	CACNB2	CACNB2	7114	0.027	0.5	NO
48	UQCRC1	UQCRC1	UQCRC1	8904	-0.00059	0.4	NO
49	SLC9A1	SLC9A1	SLC9A1	9254	-0.0065	0.39	NO
50	CACNG7	CACNG7	CACNG7	9444	-0.0094	0.38	NO
51	COX6A1	COX6A1	COX6A1	9993	-0.018	0.35	NO
52	COX7C	COX7C	COX7C	10425	-0.025	0.32	NO
53	UQCRQ	UQCRQ	UQCRQ	11037	-0.036	0.29	NO
54	COX4I2	COX4I2	COX4I2	11607	-0.047	0.26	NO
55	UQCRHL	UQCRHL	UQCRHL	11744	-0.05	0.26	NO
56	CACNA1F	CACNA1F	CACNA1F	11750	-0.05	0.26	NO
57	CACNB3	CACNB3	CACNB3	11930	-0.053	0.26	NO
58	UQCRH	UQCRH	UQCRH	12829	-0.073	0.21	NO
59	TPM4	TPM4	TPM4	13295	-0.085	0.19	NO
60	ATP1A1	ATP1A1	ATP1A1	13345	-0.086	0.19	NO
61	SLC9A6	SLC9A6	SLC9A6	13991	-0.1	0.16	NO
62	CACNG4	CACNG4	CACNG4	14795	-0.13	0.12	NO
63	FXYD2	FXYD2	FXYD2	15024	-0.14	0.12	NO
64	COX6B2	COX6B2	COX6B2	15126	-0.15	0.12	NO
65	CACNA1C	CACNA1C	CACNA1C	15833	-0.18	0.087	NO
66	CACNG5	CACNG5	CACNG5	16024	-0.2	0.086	NO
67	CACNA2D3	CACNA2D3	CACNA2D3	16801	-0.25	0.055	NO
68	ATP1B1	ATP1B1	ATP1B1	17010	-0.27	0.056	NO
69	CACNA1D	CACNA1D	CACNA1D	17530	-0.34	0.043	NO
70	SLC8A1	SLC8A1	SLC8A1	17776	-0.38	0.047	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	MYOD1	MYOD1	MYOD1	17	1.5	0.32	YES
2	CDKN1A	CDKN1A	CDKN1A	780	0.4	0.37	YES
3	FOXO4	FOXO4	FOXO4	1482	0.26	0.39	YES
4	SIRT2	SIRT2	SIRT2	1491	0.26	0.44	YES
5	TUBB2A	TUBB2A	TUBB2A	1733	0.23	0.48	YES
6	FOXO1	FOXO1	FOXO1	1843	0.22	0.52	YES
7	ACSS2	ACSS2	ACSS2	1997	0.2	0.56	YES
8	PPARGC1A	PPARGC1A	PPARGC1A	2031	0.2	0.6	YES
9	MEF2D	MEF2D	MEF2D	2552	0.16	0.6	YES
10	FHL2	FHL2	FHL2	2975	0.13	0.61	YES
11	HDAC4	HDAC4	HDAC4	4025	0.09	0.57	NO
12	SIRT1	SIRT1	SIRT1	4437	0.078	0.57	NO
13	XRCC6	XRCC6	XRCC6	6738	0.034	0.45	NO
14	TUBA1B	TUBA1B	TUBA1B	6897	0.03	0.45	NO
15	FOXO3	FOXO3	FOXO3	7634	0.019	0.41	NO
16	CREBBP	CREBBP	CREBBP	7679	0.018	0.41	NO
17	HIST1H1E	HIST1H1E	HIST1H1E	8311	0.0085	0.38	NO
18	EP300	EP300	EP300	9751	-0.014	0.31	NO
19	SIRT3	SIRT3	SIRT3	10329	-0.024	0.28	NO
20	SIRT7	SIRT7	SIRT7	11977	-0.054	0.21	NO
21	TP53	TP53	TP53	12523	-0.066	0.19	NO
22	BAX	BAX	BAX	12666	-0.069	0.2	NO
23	ACSS1	ACSS1	ACSS1	13507	-0.091	0.17	NO
24	KAT2B	KAT2B	KAT2B	15728	-0.18	0.092	NO
25	HOXA10	HOXA10	HOXA10	17247	-0.3	0.075	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	ENO3	ENO3	ENO3	44	1.4	0.12	YES
2	FBP2	FBP2	FBP2	117	1	0.21	YES
3	PYGM	PYGM	PYGM	135	0.97	0.29	YES
4	PGAM2	PGAM2	PGAM2	191	0.82	0.36	YES
5	PHKG1	PHKG1	PHKG1	201	0.79	0.44	YES
6	PFKFB1	PFKFB1	PFKFB1	820	0.39	0.44	YES
7	GYS2	GYS2	GYS2	937	0.36	0.46	YES
8	PKLR	PKLR	PKLR	1341	0.28	0.47	YES
9	GYG1	GYG1	GYG1	1349	0.28	0.49	YES
10	AGL	AGL	AGL	1605	0.24	0.5	YES
11	PFKM	PFKM	PFKM	1975	0.2	0.5	YES
12	PC	PC	PC	1981	0.2	0.52	YES
13	PRKACA	PRKACA	PRKACA	2160	0.19	0.52	YES
14	GOT1	GOT1	GOT1	2338	0.17	0.53	YES
15	GAPDHS	GAPDHS	GAPDHS	2580	0.16	0.53	YES
16	GYS1	GYS1	GYS1	3182	0.12	0.51	NO
17	ALDOA	ALDOA	ALDOA	4080	0.089	0.47	NO
18	MDH2	MDH2	MDH2	4156	0.087	0.47	NO
19	MDH1	MDH1	MDH1	4235	0.084	0.47	NO
20	UGP2	UGP2	UGP2	4462	0.078	0.47	NO
21	GPI	GPI	GPI	4757	0.071	0.46	NO
22	SLC25A12	SLC25A12	SLC25A12	5001	0.066	0.45	NO
23	SLC25A11	SLC25A11	SLC25A11	5069	0.064	0.45	NO
24	PYGL	PYGL	PYGL	5341	0.059	0.44	NO
25	PGM1	PGM1	PGM1	5515	0.055	0.44	NO
26	PGAM1	PGAM1	PGAM1	6807	0.032	0.37	NO
27	PRKACB	PRKACB	PRKACB	7497	0.021	0.34	NO
28	PKM2	PKM2	PKM2	7985	0.014	0.31	NO
29	PFKFB2	PFKFB2	PFKFB2	8282	0.009	0.3	NO
30	PPP2CA	PPP2CA	PPP2CA	8519	0.0053	0.29	NO
31	PPP2R5D	PPP2R5D	PPP2R5D	8761	0.0014	0.27	NO
32	PPP2CB	PPP2CB	PPP2CB	9119	-0.0041	0.25	NO
33	GAPDH	GAPDH	GAPDH	9208	-0.0057	0.25	NO
34	TPI1	TPI1	TPI1	9278	-0.0069	0.25	NO
35	PHKA1	PHKA1	PHKA1	9409	-0.0089	0.24	NO
36	GYG2	GYG2	GYG2	9608	-0.012	0.23	NO
37	PGK1	PGK1	PGK1	9908	-0.017	0.22	NO
38	PFKFB3	PFKFB3	PFKFB3	9965	-0.018	0.22	NO
39	ALDOC	ALDOC	ALDOC	10168	-0.021	0.21	NO
40	SLC25A13	SLC25A13	SLC25A13	10415	-0.025	0.2	NO
41	PPP2R1A	PPP2R1A	PPP2R1A	10449	-0.026	0.2	NO
42	CALM1	CALM1	CALM1	10663	-0.03	0.19	NO
43	GOT2	GOT2	GOT2	10826	-0.032	0.18	NO
44	PHKG2	PHKG2	PHKG2	11070	-0.037	0.17	NO
45	CALM2	CALM2	CALM2	11554	-0.046	0.15	NO
46	ENO1	ENO1	ENO1	11649	-0.048	0.15	NO
47	GBE1	GBE1	GBE1	11713	-0.049	0.15	NO
48	PPP2R1B	PPP2R1B	PPP2R1B	11887	-0.052	0.14	NO
49	CALM3	CALM3	CALM3	12045	-0.055	0.14	NO
50	ALDOB	ALDOB	ALDOB	13700	-0.096	0.061	NO
51	PFKL	PFKL	PFKL	14077	-0.11	0.05	NO
52	PHKA2	PHKA2	PHKA2	14109	-0.11	0.059	NO
53	PCK2	PCK2	PCK2	14458	-0.12	0.051	NO
54	PFKP	PFKP	PFKP	14501	-0.12	0.059	NO
55	PHKB	PHKB	PHKB	14515	-0.12	0.069	NO
56	ENO2	ENO2	ENO2	14662	-0.13	0.073	NO
57	PGM2	PGM2	PGM2	14896	-0.14	0.072	NO
58	SLC25A1	SLC25A1	SLC25A1	15192	-0.15	0.07	NO
59	PYGB	PYGB	PYGB	15269	-0.15	0.08	NO
60	PFKFB4	PFKFB4	PFKFB4	15377	-0.16	0.088	NO
61	SLC25A10	SLC25A10	SLC25A10	16502	-0.23	0.048	NO
62	FBP1	FBP1	FBP1	17341	-0.31	0.03	NO
63	PCK1	PCK1	PCK1	18068	-0.45	0.031	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	MYOD1	MYOD1	MYOD1	17	1.5	0.14	YES
2	CKM	CKM	CKM	25	1.4	0.27	YES
3	MEF2C	MEF2C	MEF2C	420	0.56	0.3	YES
4	PAX3	PAX3	PAX3	597	0.47	0.34	YES
5	CCND2	CCND2	CCND2	739	0.41	0.37	YES
6	CDKN1A	CDKN1A	CDKN1A	780	0.4	0.4	YES
7	SKP2	SKP2	SKP2	1050	0.34	0.42	YES
8	GSC	GSC	GSC	1266	0.29	0.44	YES
9	CCND3	CCND3	CCND3	1385	0.27	0.45	YES
10	PPP2R3B	PPP2R3B	PPP2R3B	1564	0.25	0.47	YES
11	CEBPD	CEBPD	CEBPD	1728	0.23	0.48	YES
12	CDK6	CDK6	CDK6	2280	0.18	0.47	NO
13	RB1	RB1	RB1	2370	0.17	0.48	NO
14	TGFB2	TGFB2	TGFB2	3491	0.11	0.43	NO
15	BGLAP	BGLAP	BGLAP	3669	0.1	0.43	NO
16	CCNE1	CCNE1	CCNE1	3815	0.098	0.43	NO
17	TBP	TBP	TBP	4255	0.084	0.41	NO
18	AATF	AATF	AATF	4307	0.082	0.42	NO
19	SIRT1	SIRT1	SIRT1	4437	0.078	0.42	NO
20	ATF7	ATF7	ATF7	4833	0.069	0.4	NO
21	CDK4	CDK4	CDK4	6343	0.04	0.32	NO
22	ATF2	ATF2	ATF2	6592	0.036	0.32	NO
23	SMARCA4	SMARCA4	SMARCA4	6627	0.035	0.32	NO
24	RAF1	RAF1	RAF1	6814	0.032	0.31	NO
25	CBX4	CBX4	CBX4	6906	0.03	0.31	NO
26	E2F4	E2F4	E2F4	7201	0.026	0.29	NO
27	TAF1	TAF1	TAF1	7446	0.022	0.28	NO
28	CREBBP	CREBBP	CREBBP	7679	0.018	0.27	NO
29	E2F2	E2F2	E2F2	7736	0.017	0.27	NO
30	CEBPA	CEBPA	CEBPA	7896	0.015	0.26	NO
31	ABL1	ABL1	ABL1	8077	0.012	0.26	NO
32	RBBP4	RBBP4	RBBP4	8099	0.012	0.26	NO
33	CTBP1	CTBP1	CTBP1	8334	0.0082	0.24	NO
34	PPP2CA	PPP2CA	PPP2CA	8519	0.0053	0.23	NO
35	SMARCB1	SMARCB1	SMARCB1	9228	-0.0061	0.2	NO
36	MDM2	MDM2	MDM2	9390	-0.0087	0.19	NO
37	MET	MET	MET	9399	-0.0088	0.19	NO
38	EP300	EP300	EP300	9751	-0.014	0.17	NO
39	MITF	MITF	MITF	10241	-0.022	0.15	NO
40	E2F1	E2F1	E2F1	10265	-0.023	0.15	NO
41	DNMT1	DNMT1	DNMT1	10651	-0.029	0.13	NO
42	MAPK14	MAPK14	MAPK14	10794	-0.032	0.12	NO
43	TFDP1	TFDP1	TFDP1	10910	-0.034	0.12	NO
44	SUV39H1	SUV39H1	SUV39H1	11026	-0.036	0.12	NO
45	CCNA2	CCNA2	CCNA2	11142	-0.038	0.12	NO
46	BRD2	BRD2	BRD2	11464	-0.044	0.1	NO
47	CDKN2A	CDKN2A	CDKN2A	11504	-0.045	0.1	NO
48	CDK2	CDK2	CDK2	11679	-0.048	0.1	NO
49	UBTF	UBTF	UBTF	11682	-0.048	0.1	NO
50	E2F3	E2F3	E2F3	11700	-0.049	0.11	NO
51	CEBPB	CEBPB	CEBPB	12061	-0.056	0.094	NO
52	MAPK9	MAPK9	MAPK9	12145	-0.058	0.095	NO
53	HDAC3	HDAC3	HDAC3	12181	-0.059	0.098	NO
54	CDKN1B	CDKN1B	CDKN1B	12471	-0.065	0.089	NO
55	HDAC1	HDAC1	HDAC1	13489	-0.09	0.042	NO
56	ELF1	ELF1	ELF1	13951	-0.1	0.027	NO
57	MAPK11	MAPK11	MAPK11	14353	-0.12	0.016	NO
58	JUN	JUN	JUN	14534	-0.12	0.018	NO
59	SPI1	SPI1	SPI1	15188	-0.15	-0.0032	NO
60	RBP2	RBP2	RBP2	16122	-0.2	-0.034	NO
61	CCND1	CCND1	CCND1	16568	-0.23	-0.037	NO
62	PPARG	PPARG	PPARG	17234	-0.3	-0.045	NO
63	CSF2	CSF2	CSF2	17641	-0.36	-0.034	NO
64	SFTPD	SFTPD	SFTPD	17779	-0.38	-0.0061	NO
65	RUNX2	RUNX2	RUNX2	18383	-0.57	0.014	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	CDKN1A	CDKN1A	CDKN1A	780	0.4	0.14	YES
2	FOXO4	FOXO4	FOXO4	1482	0.26	0.22	YES
3	FOXO1	FOXO1	FOXO1	1843	0.22	0.29	YES
4	THEM4	THEM4	THEM4	2030	0.2	0.37	YES
5	CASP9	CASP9	CASP9	2272	0.18	0.44	YES
6	TRIB3	TRIB3	TRIB3	2820	0.14	0.47	YES
7	PDPK1	PDPK1	PDPK1	5605	0.054	0.35	NO
8	CHUK	CHUK	CHUK	5751	0.051	0.36	NO
9	AKT2	AKT2	AKT2	5822	0.049	0.38	NO
10	RICTOR	RICTOR	RICTOR	6473	0.038	0.36	NO
11	AKT1S1	AKT1S1	AKT1S1	6649	0.035	0.37	NO
12	RPS6KB2	RPS6KB2	RPS6KB2	6660	0.035	0.38	NO
13	MAPKAP1	MAPKAP1	MAPKAP1	7190	0.026	0.37	NO
14	FOXO3	FOXO3	FOXO3	7634	0.019	0.35	NO
15	AKT1	AKT1	AKT1	7994	0.014	0.34	NO
16	TSC2	TSC2	TSC2	8118	0.012	0.34	NO
17	MLST8	MLST8	MLST8	8373	0.0077	0.33	NO
18	NR4A1	NR4A1	NR4A1	8776	0.0012	0.31	NO
19	MDM2	MDM2	MDM2	9390	-0.0087	0.28	NO
20	MTOR	MTOR	MTOR	10160	-0.021	0.25	NO
21	BAD	BAD	BAD	11424	-0.043	0.2	NO
22	AKT3	AKT3	AKT3	11623	-0.047	0.21	NO
23	GSK3A	GSK3A	GSK3A	12184	-0.059	0.2	NO
24	CREB1	CREB1	CREB1	12383	-0.063	0.22	NO
25	CDKN1B	CDKN1B	CDKN1B	12471	-0.065	0.25	NO
26	PTEN	PTEN	PTEN	13003	-0.077	0.25	NO
27	PHLPP1	PHLPP1	PHLPP1	14189	-0.11	0.24	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	TAF13	TAF13	TAF13	1799	0.22	-0.032	YES
2	TCEB1	TCEB1	TCEB1	2440	0.16	-0.018	YES
3	GTF2H2B	GTF2H2B	GTF2H2B	2546	0.16	0.022	YES
4	GTF2E1	GTF2E1	GTF2E1	3319	0.12	0.014	YES
5	GTF2B	GTF2B	GTF2B	3343	0.11	0.046	YES
6	POLR2D	POLR2D	POLR2D	3376	0.11	0.077	YES
7	TAF10	TAF10	TAF10	3409	0.11	0.11	YES
8	NCBP2	NCBP2	NCBP2	3579	0.11	0.13	YES
9	GTF2H2	GTF2H2	GTF2H2	3721	0.1	0.15	YES
10	TAF5	TAF5	TAF5	3799	0.098	0.18	YES
11	GTF2F2	GTF2F2	GTF2F2	3809	0.098	0.2	YES
12	TAF12	TAF12	TAF12	3985	0.092	0.22	YES
13	TBP	TBP	TBP	4255	0.084	0.23	YES
14	POLR2B	POLR2B	POLR2B	4338	0.081	0.25	YES
15	ELL	ELL	ELL	4504	0.077	0.26	YES
16	TCEA1	TCEA1	TCEA1	4527	0.076	0.28	YES
17	NCBP1	NCBP1	NCBP1	4895	0.068	0.28	YES
18	POLR2J	POLR2J	POLR2J	5210	0.061	0.28	YES
19	POLR2I	POLR2I	POLR2I	5297	0.059	0.3	YES
20	SUPT16H	SUPT16H	SUPT16H	5344	0.058	0.31	YES
21	TCEB3	TCEB3	TCEB3	5541	0.055	0.32	YES
22	SUPT5H	SUPT5H	SUPT5H	5579	0.054	0.33	YES
23	RDBP	RDBP	RDBP	5633	0.053	0.34	YES
24	TAF11	TAF11	TAF11	5637	0.053	0.36	YES
25	MNAT1	MNAT1	MNAT1	5716	0.051	0.37	YES
26	GTF2H3	GTF2H3	GTF2H3	5886	0.048	0.38	YES
27	TAF9	TAF9	TAF9	6014	0.046	0.38	YES
28	ERCC3	ERCC3	ERCC3	6408	0.039	0.37	YES
29	POLR2H	POLR2H	POLR2H	6448	0.038	0.38	YES
30	SSRP1	SSRP1	SSRP1	6585	0.036	0.38	YES
31	POLR2E	POLR2E	POLR2E	6597	0.036	0.39	YES
32	GTF2A2	GTF2A2	GTF2A2	6657	0.035	0.4	YES
33	POLR2G	POLR2G	POLR2G	6782	0.033	0.4	YES
34	SUPT4H1	SUPT4H1	SUPT4H1	6840	0.031	0.41	YES
35	GTF2H1	GTF2H1	GTF2H1	6877	0.031	0.42	YES
36	TAF1	TAF1	TAF1	7446	0.022	0.39	NO
37	TAF6	TAF6	TAF6	7571	0.02	0.39	NO
38	CCNT2	CCNT2	CCNT2	7747	0.017	0.39	NO
39	POLR2A	POLR2A	POLR2A	8178	0.011	0.37	NO
40	WHSC2	WHSC2	WHSC2	8463	0.0063	0.35	NO
41	POLR2F	POLR2F	POLR2F	8725	0.002	0.34	NO
42	CCNT1	CCNT1	CCNT1	9074	-0.0036	0.32	NO
43	POLR2K	POLR2K	POLR2K	9090	-0.0038	0.32	NO
44	GTF2E2	GTF2E2	GTF2E2	9167	-0.0048	0.32	NO
45	GTF2F1	GTF2F1	GTF2F1	9200	-0.0056	0.32	NO
46	POLR2C	POLR2C	POLR2C	9256	-0.0066	0.32	NO
47	CDK9	CDK9	CDK9	9454	-0.0095	0.31	NO
48	GTF2A1	GTF2A1	GTF2A1	9619	-0.012	0.31	NO
49	TCEB2	TCEB2	TCEB2	9906	-0.017	0.3	NO
50	TAF4	TAF4	TAF4	10830	-0.033	0.26	NO
51	POLR2L	POLR2L	POLR2L	11220	-0.039	0.25	NO
52	COBRA1	COBRA1	COBRA1	11397	-0.043	0.25	NO
53	TH1L	TH1L	TH1L	11428	-0.043	0.26	NO
54	ERCC2	ERCC2	ERCC2	11876	-0.052	0.25	NO
55	CTDP1	CTDP1	CTDP1	11979	-0.054	0.26	NO
56	CCNH	CCNH	CCNH	12601	-0.068	0.25	NO
57	CDK7	CDK7	CDK7	12901	-0.074	0.25	NO
58	TAF4B	TAF4B	TAF4B	13415	-0.088	0.25	NO
59	GTF2H4	GTF2H4	GTF2H4	13897	-0.1	0.26	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	MYL1	MYL1	MYL1	6	1.6	0.06	YES
2	TNNC2	TNNC2	TNNC2	12	1.5	0.12	YES
3	ACTN2	ACTN2	ACTN2	23	1.5	0.17	YES
4	MYBPC1	MYBPC1	MYBPC1	35	1.4	0.22	YES
5	MYL4	MYL4	MYL4	36	1.4	0.28	YES
6	MYH3	MYH3	MYH3	41	1.4	0.33	YES
7	NEB	NEB	NEB	42	1.4	0.38	YES
8	MYH8	MYH8	MYH8	58	1.3	0.43	YES
9	TNNC1	TNNC1	TNNC1	63	1.3	0.47	YES
10	TNNI2	TNNI2	TNNI2	83	1.2	0.52	YES
11	TNNI1	TNNI1	TNNI1	96	1.1	0.56	YES
12	TNNT2	TNNT2	TNNT2	102	1.1	0.6	YES
13	DES	DES	DES	108	1.1	0.64	YES
14	MYBPC2	MYBPC2	MYBPC2	116	1	0.68	YES
15	MYL3	MYL3	MYL3	163	0.89	0.71	YES
16	MYH6	MYH6	MYH6	166	0.88	0.74	YES
17	TCAP	TCAP	TCAP	170	0.86	0.77	YES
18	MYL2	MYL2	MYL2	176	0.86	0.8	YES
19	TNNT1	TNNT1	TNNT1	182	0.85	0.84	YES
20	TPM2	TPM2	TPM2	698	0.43	0.82	YES
21	TNNI3	TNNI3	TNNI3	858	0.38	0.83	YES
22	TMOD1	TMOD1	TMOD1	915	0.36	0.84	YES
23	MYL6B	MYL6B	MYL6B	964	0.35	0.85	YES
24	DMD	DMD	DMD	2048	0.2	0.8	NO
25	TPM1	TPM1	TPM1	2323	0.17	0.79	NO
26	MYL9	MYL9	MYL9	2593	0.15	0.78	NO
27	LMOD1	LMOD1	LMOD1	3607	0.1	0.73	NO
28	TPM3	TPM3	TPM3	4780	0.07	0.67	NO
29	SORBS1	SORBS1	SORBS1	5310	0.059	0.65	NO
30	SORBS3	SORBS3	SORBS3	6205	0.043	0.6	NO
31	VIM	VIM	VIM	7284	0.024	0.54	NO
32	MYL6	MYL6	MYL6	10132	-0.021	0.39	NO
33	CALM1	CALM1	CALM1	10663	-0.03	0.36	NO
34	TLN1	TLN1	TLN1	11181	-0.039	0.34	NO
35	VCL	VCL	VCL	11359	-0.042	0.33	NO
36	CALM2	CALM2	CALM2	11554	-0.046	0.32	NO
37	CALM3	CALM3	CALM3	12045	-0.055	0.3	NO
38	TPM4	TPM4	TPM4	13295	-0.085	0.23	NO
39	ACTA2	ACTA2	ACTA2	13817	-0.099	0.21	NO
40	MYL12B	MYL12B	MYL12B	14027	-0.11	0.2	NO
41	CALD1	CALD1	CALD1	14433	-0.12	0.18	NO
42	ITGA1	ITGA1	ITGA1	14927	-0.14	0.16	NO
43	MYLK	MYLK	MYLK	15414	-0.16	0.14	NO
44	ITGB5	ITGB5	ITGB5	15748	-0.18	0.13	NO
45	ACTG2	ACTG2	ACTG2	16232	-0.21	0.11	NO
46	MYH11	MYH11	MYH11	18084	-0.45	0.03	NO

Fold change

For the top enriched genes, if you want to check whether they are

up-regulated, please check the list of up-regulated genes
down-regulated, please check the list of down-regulated genes

Expression level

For the top enriched genes, if you want to check whether they are

highly expressed genes, please check the list of high (top 30%) expressed genes
low expressed genes, please check the list of low (bottom 30%) expressed genes

An expression pattern of top(30%)/middle(30%)/low(30%) in this subtype against other subtypes is available in a heatmap

Significant gene list

For the top enriched genes, if you want to check whether they are

significantly differently expressed genes by eBayes lm fit, please check the list of significant genes

+ Subtype clus2 enriched pathways

Table 4. Get Full Table This table shows top 10 pathways which are significantly enriched in cluster clus2. It displays only significant gene sets satisfying nom.p.val.threshold (-1), fwer.p.val.threshold (-1) , fdr.q.val.threshold (0.25) and the default table is sorted by Normalized Enrichment Score (NES). Further details on NES statistics, please visit The Broad GSEA website.

GeneSet(GS)	Size(#genes)	genes.ES.table	ES	NES	NOM.p.val	FDR.q.val	FWER.p.val	Tag..	Gene..	Signal	FDR..median.	glob.p.val
KEGG TOLL LIKE RECEPTOR SIGNALING PATHWAY	89	genes.ES.table	0.63	1.7	0.004	0.39	0.74	0.51	0.21	0.4	0.13	0.099
BIOCARTA FAS PATHWAY	30	genes.ES.table	0.51	1.8	0.022	0.5	0.69	0.37	0.2	0.29	0.15	0.12
PID HIF2PATHWAY	34	genes.ES.table	0.52	1.7	0.01	0.43	0.72	0.41	0.2	0.33	0.14	0.11
PID AVB3 OPN PATHWAY	31	genes.ES.table	0.68	1.9	0	0.56	0.27	0.48	0.2	0.39	0	0.099
PID TRAIL PATHWAY	28	genes.ES.table	0.7	2	0	0.9	0.15	0.36	0.16	0.3	0	0.12
PID FASPATHWAY	38	genes.ES.table	0.64	2	0	0.54	0.18	0.4	0.19	0.32	0	0.081
PID IL1PATHWAY	34	genes.ES.table	0.56	1.7	0.022	0.41	0.72	0.38	0.2	0.31	0.13	0.1
PID ECADHERIN NASCENTAJ PATHWAY	39	genes.ES.table	0.42	1.7	0.016	0.4	0.74	0.36	0.29	0.25	0.13	0.1
PID PDGFRBPATHWAY	127	genes.ES.table	0.42	1.8	0.028	0.47	0.7	0.23	0.2	0.18	0.14	0.12
PID TAP63PATHWAY	54	genes.ES.table	0.59	1.8	0	0.43	0.53	0.35	0.15	0.3	0.097	0.093

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	TNFRSF10A	TNFRSF10A	TNFRSF10A	145	0.6	0.15	YES
2	TNFSF10	TNFSF10	TNFSF10	210	0.55	0.3	YES
3	CASP8	CASP8	CASP8	588	0.4	0.38	YES
4	TNFRSF10C	TNFRSF10C	TNFRSF10C	730	0.37	0.47	YES
5	CASP10	CASP10	CASP10	851	0.34	0.56	YES
6	PIK3R1	PIK3R1	PIK3R1	1685	0.23	0.57	YES
7	PIK3R3	PIK3R3	PIK3R3	1801	0.22	0.63	YES
8	PIK3CB	PIK3CB	PIK3CB	2070	0.2	0.67	YES
9	CFLAR	CFLAR	CFLAR	2424	0.18	0.69	YES
10	MAP3K1	MAP3K1	MAP3K1	3055	0.14	0.7	YES
11	TRADD	TRADD	TRADD	4475	0.083	0.64	NO
12	IKBKB	IKBKB	IKBKB	4540	0.081	0.66	NO
13	RIPK1	RIPK1	RIPK1	4869	0.072	0.66	NO
14	PIK3R2	PIK3R2	PIK3R2	7184	0.024	0.54	NO
15	SMPD1	SMPD1	SMPD1	7799	0.014	0.52	NO
16	PIK3CA	PIK3CA	PIK3CA	7976	0.011	0.51	NO
17	IKBKG	IKBKG	IKBKG	8001	0.011	0.51	NO
18	MAPK3	MAPK3	MAPK3	8354	0.0053	0.49	NO
19	FADD	FADD	FADD	8488	0.0035	0.49	NO
20	MAPK8	MAPK8	MAPK8	9321	-0.0091	0.44	NO
21	TNFRSF10B	TNFRSF10B	TNFRSF10B	9882	-0.017	0.42	NO
22	TRAF2	TRAF2	TRAF2	9995	-0.019	0.42	NO
23	PIK3CD	PIK3CD	PIK3CD	10080	-0.02	0.42	NO
24	MAP2K4	MAP2K4	MAP2K4	10493	-0.026	0.4	NO
25	DAP3	DAP3	DAP3	10538	-0.026	0.41	NO
26	CHUK	CHUK	CHUK	10701	-0.029	0.41	NO
27	MAPK1	MAPK1	MAPK1	11100	-0.035	0.39	NO
28	TNFRSF10D	TNFRSF10D	TNFRSF10D	11492	-0.041	0.38	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	SYK	SYK	SYK	281	0.51	0.1	YES
2	MAPK10	MAPK10	MAPK10	543	0.42	0.18	YES
3	CASP8	CASP8	CASP8	588	0.4	0.27	YES
4	CASP10	CASP10	CASP10	851	0.34	0.33	YES
5	FAS	FAS	FAS	1047	0.31	0.39	YES
6	PIK3R1	PIK3R1	PIK3R1	1685	0.23	0.41	YES
7	PIK3R3	PIK3R3	PIK3R3	1801	0.22	0.46	YES
8	PIK3CB	PIK3CB	PIK3CB	2070	0.2	0.49	YES
9	MAP2K6	MAP2K6	MAP2K6	2265	0.19	0.52	YES
10	CFLAR	CFLAR	CFLAR	2424	0.18	0.55	YES
11	BIRC3	BIRC3	BIRC3	2807	0.15	0.56	YES
12	MAP3K1	MAP3K1	MAP3K1	3055	0.14	0.58	YES
13	EZR	EZR	EZR	3349	0.12	0.6	YES
14	FASLG	FASLG	FASLG	3452	0.12	0.62	YES
15	BTK	BTK	BTK	3551	0.12	0.64	YES
16	IKBKB	IKBKB	IKBKB	4540	0.081	0.6	NO
17	RIPK1	RIPK1	RIPK1	4869	0.072	0.6	NO
18	RFC1	RFC1	RFC1	6723	0.033	0.51	NO
19	PIK3R2	PIK3R2	PIK3R2	7184	0.024	0.49	NO
20	CASP3	CASP3	CASP3	7304	0.022	0.49	NO
21	SMPD1	SMPD1	SMPD1	7799	0.014	0.47	NO
22	PIK3CA	PIK3CA	PIK3CA	7976	0.011	0.46	NO
23	IKBKG	IKBKG	IKBKG	8001	0.011	0.46	NO
24	AKT1	AKT1	AKT1	8029	0.011	0.46	NO
25	CLTC	CLTC	CLTC	8482	0.0036	0.44	NO
26	FADD	FADD	FADD	8488	0.0035	0.44	NO
27	MAP2K7	MAP2K7	MAP2K7	8526	0.003	0.44	NO
28	BIRC2	BIRC2	BIRC2	8973	-0.0042	0.42	NO
29	MAPK9	MAPK9	MAPK9	9190	-0.0073	0.4	NO
30	MAPK8	MAPK8	MAPK8	9321	-0.0091	0.4	NO
31	PIK3CD	PIK3CD	PIK3CD	10080	-0.02	0.36	NO
32	BID	BID	BID	10192	-0.021	0.36	NO
33	MAPK14	MAPK14	MAPK14	10638	-0.028	0.34	NO
34	CHUK	CHUK	CHUK	10701	-0.029	0.35	NO
35	MAPK11	MAPK11	MAPK11	11967	-0.048	0.29	NO
36	PDPK1	PDPK1	PDPK1	12670	-0.062	0.27	NO
37	SRC	SRC	SRC	13785	-0.086	0.23	NO
38	FAIM2	FAIM2	FAIM2	15517	-0.15	0.17	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	VAV3	VAV3	VAV3	190	0.57	0.13	YES
2	SYK	SYK	SYK	281	0.51	0.25	YES
3	CD44	CD44	CD44	901	0.33	0.29	YES
4	PLAU	PLAU	PLAU	1039	0.31	0.36	YES
5	FOS	FOS	FOS	1151	0.29	0.42	YES
6	ITGB3	ITGB3	ITGB3	1438	0.26	0.47	YES
7	PIK3R1	PIK3R1	PIK3R1	1685	0.23	0.51	YES
8	PTK2B	PTK2B	PTK2B	2029	0.2	0.55	YES
9	NFKBIA	NFKBIA	NFKBIA	2493	0.17	0.56	YES
10	MMP9	MMP9	MMP9	2859	0.15	0.58	YES
11	ITGAV	ITGAV	ITGAV	3010	0.14	0.6	YES
12	MAP3K1	MAP3K1	MAP3K1	3055	0.14	0.63	YES
13	MMP2	MMP2	MMP2	3271	0.13	0.65	YES
14	SPP1	SPP1	SPP1	3643	0.11	0.66	YES
15	JUN	JUN	JUN	3757	0.11	0.68	YES
16	GSN	GSN	GSN	4666	0.077	0.65	NO
17	NFKB1	NFKB1	NFKB1	5025	0.068	0.65	NO
18	RHOA	RHOA	RHOA	5113	0.066	0.66	NO
19	ILK	ILK	ILK	5903	0.049	0.63	NO
20	PIK3CA	PIK3CA	PIK3CA	7976	0.011	0.52	NO
21	ROCK2	ROCK2	ROCK2	8047	0.01	0.52	NO
22	RELA	RELA	RELA	8074	0.01	0.52	NO
23	BCAR1	BCAR1	BCAR1	8349	0.0054	0.5	NO
24	MAPK3	MAPK3	MAPK3	8354	0.0053	0.51	NO
25	CDC42	CDC42	CDC42	8629	0.0013	0.49	NO
26	RAC1	RAC1	RAC1	8804	-0.0012	0.48	NO
27	MAPK8	MAPK8	MAPK8	9321	-0.0091	0.46	NO
28	CHUK	CHUK	CHUK	10701	-0.029	0.39	NO
29	MAPK1	MAPK1	MAPK1	11100	-0.035	0.38	NO
30	PIP5K1A	PIP5K1A	PIP5K1A	11318	-0.038	0.37	NO
31	MAP3K14	MAP3K14	MAP3K14	13569	-0.08	0.27	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	TLR3	TLR3	TLR3	192	0.57	0.06	YES
2	RIPK3	RIPK3	RIPK3	418	0.45	0.1	YES
3	RPS6KA5	RPS6KA5	RPS6KA5	489	0.43	0.15	YES
4	MAPK10	MAPK10	MAPK10	543	0.42	0.2	YES
5	SAA1	SAA1	SAA1	669	0.38	0.24	YES
6	S100B	S100B	S100B	913	0.33	0.27	YES
7	FOS	FOS	FOS	1151	0.29	0.3	YES
8	RPS6KA2	RPS6KA2	RPS6KA2	1197	0.29	0.33	YES
9	IRF7	IRF7	IRF7	1228	0.28	0.36	YES
10	TICAM1	TICAM1	TICAM1	1475	0.26	0.38	YES
11	DUSP4	DUSP4	DUSP4	1785	0.23	0.39	YES
12	MAP2K6	MAP2K6	MAP2K6	2265	0.19	0.39	YES
13	RIPK2	RIPK2	RIPK2	2307	0.18	0.41	YES
14	RPS6KA1	RPS6KA1	RPS6KA1	2317	0.18	0.43	YES
15	IKBKE	IKBKE	IKBKE	2456	0.17	0.45	YES
16	NFKBIA	NFKBIA	NFKBIA	2493	0.17	0.47	YES
17	IRAK2	IRAK2	IRAK2	2966	0.14	0.46	YES
18	ZBP1	ZBP1	ZBP1	3365	0.12	0.45	YES
19	MAP2K3	MAP2K3	MAP2K3	3544	0.12	0.46	YES
20	PPP2CB	PPP2CB	PPP2CB	3717	0.11	0.46	YES
21	JUN	JUN	JUN	3757	0.11	0.47	YES
22	DUSP6	DUSP6	DUSP6	4168	0.093	0.46	NO
23	IKBKB	IKBKB	IKBKB	4540	0.081	0.45	NO
24	RIPK1	RIPK1	RIPK1	4869	0.072	0.44	NO
25	PPP2R1B	PPP2R1B	PPP2R1B	5137	0.065	0.44	NO
26	APP	APP	APP	5186	0.064	0.44	NO
27	TRAF6	TRAF6	TRAF6	6010	0.046	0.4	NO
28	CREB1	CREB1	CREB1	6264	0.041	0.4	NO
29	IRF3	IRF3	IRF3	6717	0.033	0.38	NO
30	UBA52	UBA52	UBA52	7115	0.025	0.36	NO
31	MAPKAPK2	MAPKAPK2	MAPKAPK2	7143	0.025	0.36	NO
32	NOD2	NOD2	NOD2	7889	0.013	0.32	NO
33	IKBKG	IKBKG	IKBKG	8001	0.011	0.32	NO
34	RELA	RELA	RELA	8074	0.01	0.31	NO
35	NOD1	NOD1	NOD1	8094	0.0096	0.31	NO
36	PPP2CA	PPP2CA	PPP2CA	8313	0.006	0.3	NO
37	MAPK3	MAPK3	MAPK3	8354	0.0053	0.3	NO
38	MAP2K7	MAP2K7	MAP2K7	8526	0.003	0.29	NO
39	TBK1	TBK1	TBK1	8710	0.00027	0.28	NO
40	PPP2R1A	PPP2R1A	PPP2R1A	8782	-0.00082	0.28	NO
41	TAB2	TAB2	TAB2	9183	-0.0072	0.26	NO
42	MAPK9	MAPK9	MAPK9	9190	-0.0073	0.26	NO
43	IRAK1	IRAK1	IRAK1	9233	-0.0078	0.26	NO
44	MAPK8	MAPK8	MAPK8	9321	-0.0091	0.25	NO
45	DUSP3	DUSP3	DUSP3	9886	-0.017	0.22	NO
46	CDK1	CDK1	CDK1	10001	-0.019	0.22	NO
47	HMGB1	HMGB1	HMGB1	10049	-0.02	0.22	NO
48	MAP2K2	MAP2K2	MAP2K2	10081	-0.02	0.22	NO
49	MAP2K4	MAP2K4	MAP2K4	10493	-0.026	0.2	NO
50	MAPK14	MAPK14	MAPK14	10638	-0.028	0.2	NO
51	CHUK	CHUK	CHUK	10701	-0.029	0.2	NO
52	MAPK1	MAPK1	MAPK1	11100	-0.035	0.18	NO
53	MAPK7	MAPK7	MAPK7	11257	-0.037	0.18	NO
54	TAB1	TAB1	TAB1	11475	-0.04	0.17	NO
55	RPS27A	RPS27A	RPS27A	11845	-0.046	0.16	NO
56	PPP2R5D	PPP2R5D	PPP2R5D	11947	-0.048	0.16	NO
57	MAPK11	MAPK11	MAPK11	11967	-0.048	0.16	NO
58	MAPKAPK3	MAPKAPK3	MAPKAPK3	12047	-0.05	0.16	NO
59	TAB3	TAB3	TAB3	12152	-0.052	0.16	NO
60	NFKB2	NFKB2	NFKB2	12851	-0.065	0.14	NO
61	MEF2A	MEF2A	MEF2A	12921	-0.067	0.14	NO
62	RPS6KA3	RPS6KA3	RPS6KA3	12945	-0.067	0.15	NO
63	ELK1	ELK1	ELK1	13429	-0.077	0.13	NO
64	MAP2K1	MAP2K1	MAP2K1	13529	-0.079	0.14	NO
65	S100A12	S100A12	S100A12	13695	-0.083	0.14	NO
66	MAP3K7	MAP3K7	MAP3K7	13740	-0.084	0.14	NO
67	ATF2	ATF2	ATF2	14231	-0.099	0.13	NO
68	ATF1	ATF1	ATF1	15089	-0.13	0.1	NO
69	DUSP7	DUSP7	DUSP7	15224	-0.14	0.11	NO
70	AGER	AGER	AGER	15246	-0.14	0.13	NO
71	NFKBIB	NFKBIB	NFKBIB	16249	-0.2	0.097	NO
72	MEF2C	MEF2C	MEF2C	16865	-0.25	0.096	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	AP1M2	AP1M2	AP1M2	39	0.76	0.089	YES
2	KLC3	KLC3	KLC3	825	0.34	0.088	YES
3	HLA-DRB5	HLA-DRB5	HLA-DRB5	869	0.34	0.13	YES
4	CTSK	CTSK	CTSK	1142	0.3	0.15	YES
5	HLA-DMA	HLA-DMA	HLA-DMA	1202	0.29	0.18	YES
6	SH3GL2	SH3GL2	SH3GL2	1285	0.28	0.21	YES
7	HLA-DQA2	HLA-DQA2	HLA-DQA2	1292	0.28	0.24	YES
8	HLA-DRB1	HLA-DRB1	HLA-DRB1	1352	0.27	0.27	YES
9	CTSO	CTSO	CTSO	1427	0.26	0.3	YES
10	HLA-DOB	HLA-DOB	HLA-DOB	1428	0.26	0.33	YES
11	DYNC1I1	DYNC1I1	DYNC1I1	1450	0.26	0.36	YES
12	HLA-DQA1	HLA-DQA1	HLA-DQA1	1664	0.24	0.38	YES
13	CTSH	CTSH	CTSH	2073	0.2	0.38	YES
14	CD74	CD74	CD74	2104	0.2	0.4	YES
15	HLA-DPA1	HLA-DPA1	HLA-DPA1	2164	0.19	0.42	YES
16	CTSS	CTSS	CTSS	2214	0.19	0.44	YES
17	HLA-DPB1	HLA-DPB1	HLA-DPB1	2351	0.18	0.46	YES
18	CTSB	CTSB	CTSB	2598	0.16	0.46	YES
19	HLA-DMB	HLA-DMB	HLA-DMB	2782	0.15	0.47	YES
20	RILP	RILP	RILP	3160	0.13	0.46	NO
21	CTSD	CTSD	CTSD	3830	0.1	0.44	NO
22	CTSC	CTSC	CTSC	4057	0.096	0.44	NO
23	DCTN6	DCTN6	DCTN6	4808	0.073	0.41	NO
24	SAR1B	SAR1B	SAR1B	5725	0.052	0.37	NO
25	LGMN	LGMN	LGMN	5837	0.05	0.37	NO
26	SEC24D	SEC24D	SEC24D	5948	0.048	0.37	NO
27	AP2S1	AP2S1	AP2S1	6172	0.043	0.36	NO
28	AP1S1	AP1S1	AP1S1	6340	0.04	0.36	NO
29	SPTBN2	SPTBN2	SPTBN2	6564	0.036	0.35	NO
30	SEC24B	SEC24B	SEC24B	6665	0.034	0.35	NO
31	AP1G1	AP1G1	AP1G1	6781	0.032	0.34	NO
32	CANX	CANX	CANX	6975	0.028	0.34	NO
33	DYNC1LI2	DYNC1LI2	DYNC1LI2	7102	0.026	0.33	NO
34	CLTA	CLTA	CLTA	7258	0.022	0.33	NO
35	DYNLL1	DYNLL1	DYNLL1	7352	0.021	0.32	NO
36	SEC24C	SEC24C	SEC24C	7355	0.021	0.33	NO
37	CTSA	CTSA	CTSA	7562	0.018	0.32	NO
38	DYNLL2	DYNLL2	DYNLL2	7759	0.015	0.31	NO
39	KIF4B	KIF4B	KIF4B	7876	0.013	0.3	NO
40	DCTN3	DCTN3	DCTN3	8014	0.011	0.3	NO
41	CTSL2	CTSL2	CTSL2	8070	0.01	0.3	NO
42	KIF2A	KIF2A	KIF2A	8082	0.0098	0.3	NO
43	KIFAP3	KIFAP3	KIFAP3	8100	0.0095	0.3	NO
44	AP1B1	AP1B1	AP1B1	8122	0.0091	0.3	NO
45	KIF5A	KIF5A	KIF5A	8241	0.0071	0.29	NO
46	CLTC	CLTC	CLTC	8482	0.0036	0.28	NO
47	DCTN4	DCTN4	DCTN4	8494	0.0034	0.28	NO
48	DYNC1H1	DYNC1H1	DYNC1H1	8599	0.0018	0.27	NO
49	DCTN5	DCTN5	DCTN5	8748	-0.00049	0.27	NO
50	AP2M1	AP2M1	AP2M1	8850	-0.002	0.26	NO
51	AP2A1	AP2A1	AP2A1	9036	-0.0052	0.25	NO
52	KIF3B	KIF3B	KIF3B	9127	-0.0065	0.25	NO
53	ARF1	ARF1	ARF1	9417	-0.01	0.23	NO
54	AP2A2	AP2A2	AP2A2	9492	-0.012	0.23	NO
55	DNM2	DNM2	DNM2	9573	-0.013	0.23	NO
56	OSBPL1A	OSBPL1A	OSBPL1A	9653	-0.014	0.22	NO
57	RACGAP1	RACGAP1	RACGAP1	9709	-0.015	0.22	NO
58	SEC31A	SEC31A	SEC31A	9834	-0.016	0.22	NO
59	CTSF	CTSF	CTSF	10011	-0.019	0.21	NO
60	ACTR1B	ACTR1B	ACTR1B	10029	-0.019	0.21	NO
61	DCTN2	DCTN2	DCTN2	10190	-0.021	0.21	NO
62	KLC1	KLC1	KLC1	10539	-0.026	0.19	NO
63	ACTR1A	ACTR1A	ACTR1A	10559	-0.027	0.19	NO
64	KIF5B	KIF5B	KIF5B	10718	-0.029	0.19	NO
65	RAB7A	RAB7A	RAB7A	10719	-0.029	0.19	NO
66	DYNC2LI1	DYNC2LI1	DYNC2LI1	10732	-0.029	0.2	NO
67	KLC2	KLC2	KLC2	10827	-0.031	0.19	NO
68	AP2B1	AP2B1	AP2B1	11037	-0.034	0.19	NO
69	DCTN1	DCTN1	DCTN1	11246	-0.037	0.18	NO
70	SEC23A	SEC23A	SEC23A	11308	-0.038	0.18	NO
71	DYNC1I2	DYNC1I2	DYNC1I2	11400	-0.039	0.18	NO
72	CTSL1	CTSL1	CTSL1	11498	-0.041	0.18	NO
73	KIF4A	KIF4A	KIF4A	11545	-0.041	0.18	NO
74	AP1S2	AP1S2	AP1S2	11651	-0.043	0.18	NO
75	SEC13	SEC13	SEC13	11820	-0.046	0.18	NO
76	KIF20A	KIF20A	KIF20A	12010	-0.049	0.18	NO
77	KLC4	KLC4	KLC4	12044	-0.05	0.18	NO
78	KIF18A	KIF18A	KIF18A	12503	-0.058	0.16	NO
79	KIF3C	KIF3C	KIF3C	13099	-0.07	0.14	NO
80	KIF22	KIF22	KIF22	13800	-0.086	0.11	NO
81	KIF23	KIF23	KIF23	13956	-0.09	0.11	NO
82	KIF11	KIF11	KIF11	14341	-0.1	0.1	NO
83	KIF2C	KIF2C	KIF2C	14422	-0.1	0.11	NO
84	DYNC2H1	DYNC2H1	DYNC2H1	14546	-0.11	0.12	NO
85	KIF15	KIF15	KIF15	14575	-0.11	0.13	NO
86	AP1M1	AP1M1	AP1M1	14934	-0.12	0.13	NO
87	DNM1	DNM1	DNM1	15457	-0.15	0.12	NO
88	HLA-DOA	HLA-DOA	HLA-DOA	15977	-0.18	0.11	NO
89	KIF26A	KIF26A	KIF26A	17124	-0.28	0.082	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	TLR3	TLR3	TLR3	192	0.57	0.063	YES
2	RPS6KA5	RPS6KA5	RPS6KA5	489	0.43	0.1	YES
3	MAPK10	MAPK10	MAPK10	543	0.42	0.15	YES
4	SAA1	SAA1	SAA1	669	0.38	0.2	YES
5	S100B	S100B	S100B	913	0.33	0.23	YES
6	FOS	FOS	FOS	1151	0.29	0.25	YES
7	RPS6KA2	RPS6KA2	RPS6KA2	1197	0.29	0.29	YES
8	TLR4	TLR4	TLR4	1437	0.26	0.31	YES
9	TICAM2	TICAM2	TICAM2	1464	0.26	0.34	YES
10	TICAM1	TICAM1	TICAM1	1475	0.26	0.37	YES
11	DUSP4	DUSP4	DUSP4	1785	0.23	0.38	YES
12	MAP2K6	MAP2K6	MAP2K6	2265	0.19	0.38	YES
13	RIPK2	RIPK2	RIPK2	2307	0.18	0.4	YES
14	RPS6KA1	RPS6KA1	RPS6KA1	2317	0.18	0.43	YES
15	NFKBIA	NFKBIA	NFKBIA	2493	0.17	0.44	YES
16	CD14	CD14	CD14	2691	0.16	0.45	YES
17	IRAK2	IRAK2	IRAK2	2966	0.14	0.45	YES
18	MAP2K3	MAP2K3	MAP2K3	3544	0.12	0.44	YES
19	PPP2CB	PPP2CB	PPP2CB	3717	0.11	0.44	YES
20	JUN	JUN	JUN	3757	0.11	0.45	YES
21	DUSP6	DUSP6	DUSP6	4168	0.093	0.44	NO
22	IKBKB	IKBKB	IKBKB	4540	0.081	0.43	NO
23	LY96	LY96	LY96	4852	0.072	0.43	NO
24	RIPK1	RIPK1	RIPK1	4869	0.072	0.44	NO
25	PPP2R1B	PPP2R1B	PPP2R1B	5137	0.065	0.43	NO
26	APP	APP	APP	5186	0.064	0.44	NO
27	TRAF6	TRAF6	TRAF6	6010	0.046	0.4	NO
28	CREB1	CREB1	CREB1	6264	0.041	0.39	NO
29	UBA52	UBA52	UBA52	7115	0.025	0.35	NO
30	MAPKAPK2	MAPKAPK2	MAPKAPK2	7143	0.025	0.35	NO
31	NOD2	NOD2	NOD2	7889	0.013	0.31	NO
32	IKBKG	IKBKG	IKBKG	8001	0.011	0.3	NO
33	RELA	RELA	RELA	8074	0.01	0.3	NO
34	NOD1	NOD1	NOD1	8094	0.0096	0.3	NO
35	PPP2CA	PPP2CA	PPP2CA	8313	0.006	0.29	NO
36	MAPK3	MAPK3	MAPK3	8354	0.0053	0.29	NO
37	MAP2K7	MAP2K7	MAP2K7	8526	0.003	0.28	NO
38	PPP2R1A	PPP2R1A	PPP2R1A	8782	-0.00082	0.27	NO
39	TAB2	TAB2	TAB2	9183	-0.0072	0.25	NO
40	MAPK9	MAPK9	MAPK9	9190	-0.0073	0.25	NO
41	IRAK1	IRAK1	IRAK1	9233	-0.0078	0.25	NO
42	MAPK8	MAPK8	MAPK8	9321	-0.0091	0.24	NO
43	DUSP3	DUSP3	DUSP3	9886	-0.017	0.22	NO
44	CDK1	CDK1	CDK1	10001	-0.019	0.21	NO
45	HMGB1	HMGB1	HMGB1	10049	-0.02	0.21	NO
46	MAP2K2	MAP2K2	MAP2K2	10081	-0.02	0.21	NO
47	MAP2K4	MAP2K4	MAP2K4	10493	-0.026	0.19	NO
48	MAPK14	MAPK14	MAPK14	10638	-0.028	0.19	NO
49	CHUK	CHUK	CHUK	10701	-0.029	0.19	NO
50	MAPK1	MAPK1	MAPK1	11100	-0.035	0.17	NO
51	MAPK7	MAPK7	MAPK7	11257	-0.037	0.17	NO
52	TAB1	TAB1	TAB1	11475	-0.04	0.16	NO
53	RPS27A	RPS27A	RPS27A	11845	-0.046	0.15	NO
54	PPP2R5D	PPP2R5D	PPP2R5D	11947	-0.048	0.15	NO
55	MAPK11	MAPK11	MAPK11	11967	-0.048	0.16	NO
56	MAPKAPK3	MAPKAPK3	MAPKAPK3	12047	-0.05	0.16	NO
57	TAB3	TAB3	TAB3	12152	-0.052	0.16	NO
58	NFKB2	NFKB2	NFKB2	12851	-0.065	0.13	NO
59	MEF2A	MEF2A	MEF2A	12921	-0.067	0.13	NO
60	RPS6KA3	RPS6KA3	RPS6KA3	12945	-0.067	0.14	NO
61	ELK1	ELK1	ELK1	13429	-0.077	0.12	NO
62	MAP2K1	MAP2K1	MAP2K1	13529	-0.079	0.13	NO
63	S100A12	S100A12	S100A12	13695	-0.083	0.13	NO
64	MAP3K7	MAP3K7	MAP3K7	13740	-0.084	0.14	NO
65	ATF2	ATF2	ATF2	14231	-0.099	0.13	NO
66	ATF1	ATF1	ATF1	15089	-0.13	0.097	NO
67	DUSP7	DUSP7	DUSP7	15224	-0.14	0.11	NO
68	AGER	AGER	AGER	15246	-0.14	0.12	NO
69	NFKBIB	NFKBIB	NFKBIB	16249	-0.2	0.096	NO
70	MEF2C	MEF2C	MEF2C	16865	-0.25	0.096	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	TLR3	TLR3	TLR3	192	0.57	0.044	YES
2	RPS6KA5	RPS6KA5	RPS6KA5	489	0.43	0.068	YES
3	MAPK10	MAPK10	MAPK10	543	0.42	0.1	YES
4	SAA1	SAA1	SAA1	669	0.38	0.13	YES
5	TLR1	TLR1	TLR1	684	0.38	0.17	YES
6	S100B	S100B	S100B	913	0.33	0.19	YES
7	FOS	FOS	FOS	1151	0.29	0.2	YES
8	SIGIRR	SIGIRR	SIGIRR	1176	0.29	0.23	YES
9	RPS6KA2	RPS6KA2	RPS6KA2	1197	0.29	0.26	YES
10	IRF7	IRF7	IRF7	1228	0.28	0.28	YES
11	TLR4	TLR4	TLR4	1437	0.26	0.29	YES
12	TICAM2	TICAM2	TICAM2	1464	0.26	0.32	YES
13	TICAM1	TICAM1	TICAM1	1475	0.26	0.34	YES
14	DUSP4	DUSP4	DUSP4	1785	0.23	0.35	YES
15	TLR2	TLR2	TLR2	1903	0.22	0.36	YES
16	PELI2	PELI2	PELI2	1977	0.21	0.38	YES
17	MAP2K6	MAP2K6	MAP2K6	2265	0.19	0.38	YES
18	RIPK2	RIPK2	RIPK2	2307	0.18	0.39	YES
19	RPS6KA1	RPS6KA1	RPS6KA1	2317	0.18	0.41	YES
20	IKBKE	IKBKE	IKBKE	2456	0.17	0.42	YES
21	NFKBIA	NFKBIA	NFKBIA	2493	0.17	0.43	YES
22	TLR6	TLR6	TLR6	2576	0.16	0.44	YES
23	CD14	CD14	CD14	2691	0.16	0.45	YES
24	MYD88	MYD88	MYD88	2798	0.15	0.46	YES
25	IRAK2	IRAK2	IRAK2	2966	0.14	0.47	YES
26	MAP3K1	MAP3K1	MAP3K1	3055	0.14	0.47	YES
27	IRAK4	IRAK4	IRAK4	3421	0.12	0.47	YES
28	MAP2K3	MAP2K3	MAP2K3	3544	0.12	0.47	YES
29	BTK	BTK	BTK	3551	0.12	0.48	YES
30	PPP2CB	PPP2CB	PPP2CB	3717	0.11	0.48	YES
31	JUN	JUN	JUN	3757	0.11	0.49	YES
32	DUSP6	DUSP6	DUSP6	4168	0.093	0.48	NO
33	IKBKB	IKBKB	IKBKB	4540	0.081	0.46	NO
34	LY96	LY96	LY96	4852	0.072	0.46	NO
35	RIPK1	RIPK1	RIPK1	4869	0.072	0.46	NO
36	PPP2R1B	PPP2R1B	PPP2R1B	5137	0.065	0.45	NO
37	APP	APP	APP	5186	0.064	0.46	NO
38	TRAF6	TRAF6	TRAF6	6010	0.046	0.42	NO
39	TMEM189-UBE2V1	TMEM189-UBE2V1	TMEM189-UBE2V1	6188	0.043	0.41	NO
40	CREB1	CREB1	CREB1	6264	0.041	0.41	NO
41	IRF3	IRF3	IRF3	6717	0.033	0.39	NO
42	TIRAP	TIRAP	TIRAP	6832	0.031	0.39	NO
43	UBA52	UBA52	UBA52	7115	0.025	0.37	NO
44	MAPKAPK2	MAPKAPK2	MAPKAPK2	7143	0.025	0.37	NO
45	UBE2N	UBE2N	UBE2N	7390	0.02	0.36	NO
46	PELI1	PELI1	PELI1	7593	0.017	0.35	NO
47	NOD2	NOD2	NOD2	7889	0.013	0.34	NO
48	IKBKG	IKBKG	IKBKG	8001	0.011	0.33	NO
49	RELA	RELA	RELA	8074	0.01	0.33	NO
50	NOD1	NOD1	NOD1	8094	0.0096	0.33	NO
51	PPP2CA	PPP2CA	PPP2CA	8313	0.006	0.32	NO
52	MAPK3	MAPK3	MAPK3	8354	0.0053	0.32	NO
53	MAP2K7	MAP2K7	MAP2K7	8526	0.003	0.31	NO
54	TBK1	TBK1	TBK1	8710	0.00027	0.3	NO
55	PPP2R1A	PPP2R1A	PPP2R1A	8782	-0.00082	0.3	NO
56	TAB2	TAB2	TAB2	9183	-0.0072	0.28	NO
57	MAPK9	MAPK9	MAPK9	9190	-0.0073	0.28	NO
58	IRAK1	IRAK1	IRAK1	9233	-0.0078	0.27	NO
59	MAPK8	MAPK8	MAPK8	9321	-0.0091	0.27	NO
60	TRAF3	TRAF3	TRAF3	9662	-0.014	0.25	NO
61	DUSP3	DUSP3	DUSP3	9886	-0.017	0.24	NO
62	CDK1	CDK1	CDK1	10001	-0.019	0.24	NO
63	HMGB1	HMGB1	HMGB1	10049	-0.02	0.24	NO
64	MAP2K2	MAP2K2	MAP2K2	10081	-0.02	0.24	NO
65	MAP2K4	MAP2K4	MAP2K4	10493	-0.026	0.22	NO
66	MAPK14	MAPK14	MAPK14	10638	-0.028	0.21	NO
67	CHUK	CHUK	CHUK	10701	-0.029	0.21	NO
68	ECSIT	ECSIT	ECSIT	10956	-0.032	0.2	NO
69	MAPK1	MAPK1	MAPK1	11100	-0.035	0.2	NO
70	MAPK7	MAPK7	MAPK7	11257	-0.037	0.19	NO
71	PELI3	PELI3	PELI3	11460	-0.04	0.18	NO
72	TAB1	TAB1	TAB1	11475	-0.04	0.19	NO
73	RPS27A	RPS27A	RPS27A	11845	-0.046	0.17	NO
74	PPP2R5D	PPP2R5D	PPP2R5D	11947	-0.048	0.17	NO
75	MAPK11	MAPK11	MAPK11	11967	-0.048	0.18	NO
76	MAPKAPK3	MAPKAPK3	MAPKAPK3	12047	-0.05	0.18	NO
77	TAB3	TAB3	TAB3	12152	-0.052	0.18	NO
78	NFKB2	NFKB2	NFKB2	12851	-0.065	0.14	NO
79	MEF2A	MEF2A	MEF2A	12921	-0.067	0.15	NO
80	RPS6KA3	RPS6KA3	RPS6KA3	12945	-0.067	0.15	NO
81	ELK1	ELK1	ELK1	13429	-0.077	0.13	NO
82	MAP2K1	MAP2K1	MAP2K1	13529	-0.079	0.14	NO
83	S100A12	S100A12	S100A12	13695	-0.083	0.13	NO
84	MAP3K7	MAP3K7	MAP3K7	13740	-0.084	0.14	NO
85	ATF2	ATF2	ATF2	14231	-0.099	0.12	NO
86	ATF1	ATF1	ATF1	15089	-0.13	0.088	NO
87	DUSP7	DUSP7	DUSP7	15224	-0.14	0.094	NO
88	AGER	AGER	AGER	15246	-0.14	0.11	NO
89	NFKBIB	NFKBIB	NFKBIB	16249	-0.2	0.07	NO
90	MEF2C	MEF2C	MEF2C	16865	-0.25	0.061	NO
91	IRAK3	IRAK3	IRAK3	17737	-0.36	0.049	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	NOXA1	NOXA1	NOXA1	287	0.51	0.096	YES
2	CDH1	CDH1	CDH1	410	0.46	0.19	YES
3	PIP5K1B	PIP5K1B	PIP5K1B	1568	0.25	0.18	YES
4	CYBB	CYBB	CYBB	1841	0.22	0.22	YES
5	MAP2K6	MAP2K6	MAP2K6	2265	0.19	0.23	YES
6	CYBA	CYBA	CYBA	2286	0.18	0.27	YES
7	NCF2	NCF2	NCF2	2328	0.18	0.31	YES
8	NCF1	NCF1	NCF1	2471	0.17	0.34	YES
9	IQGAP1	IQGAP1	IQGAP1	2521	0.17	0.38	YES
10	MAP3K1	MAP3K1	MAP3K1	3055	0.14	0.38	YES
11	ARPC1B	ARPC1B	ARPC1B	3386	0.12	0.39	YES
12	MAP2K3	MAP2K3	MAP2K3	3544	0.12	0.4	YES
13	CTNNA1	CTNNA1	CTNNA1	3682	0.11	0.42	YES
14	JUN	JUN	JUN	3757	0.11	0.44	YES
15	NOXO1	NOXO1	NOXO1	3965	0.099	0.45	YES
16	ARHGAP5	ARHGAP5	ARHGAP5	4539	0.081	0.44	YES
17	ABI1	ABI1	ABI1	4741	0.075	0.44	YES
18	CRK	CRK	CRK	4884	0.071	0.45	YES
19	NOX1	NOX1	NOX1	4935	0.07	0.46	YES
20	ARPC5	ARPC5	ARPC5	5070	0.067	0.47	YES
21	ACTR3	ACTR3	ACTR3	5385	0.059	0.47	YES
22	MAP3K11	MAP3K11	MAP3K11	5489	0.057	0.48	YES
23	STAT3	STAT3	STAT3	5634	0.054	0.48	YES
24	PAK1	PAK1	PAK1	5732	0.052	0.48	YES
25	ARPC3	ARPC3	ARPC3	5817	0.051	0.49	YES
26	CTNNB1	CTNNB1	CTNNB1	6328	0.04	0.47	NO
27	IQGAP3	IQGAP3	IQGAP3	6533	0.036	0.47	NO
28	WASF1	WASF1	WASF1	7762	0.015	0.41	NO
29	CFL1	CFL1	CFL1	7924	0.012	0.4	NO
30	BCAR1	BCAR1	BCAR1	8349	0.0054	0.38	NO
31	ARPC2	ARPC2	ARPC2	8461	0.0039	0.38	NO
32	ACTR2	ACTR2	ACTR2	8500	0.0033	0.37	NO
33	MAP2K7	MAP2K7	MAP2K7	8526	0.003	0.37	NO
34	NCKAP1	NCKAP1	NCKAP1	8661	0.00094	0.37	NO
35	RAC1	RAC1	RAC1	8804	-0.0012	0.36	NO
36	PIP5K1C	PIP5K1C	PIP5K1C	9003	-0.0047	0.35	NO
37	MAPK9	MAPK9	MAPK9	9190	-0.0073	0.34	NO
38	MAPK8	MAPK8	MAPK8	9321	-0.0091	0.34	NO
39	CYFIP2	CYFIP2	CYFIP2	9517	-0.012	0.33	NO
40	RACGAP1	RACGAP1	RACGAP1	9709	-0.015	0.32	NO
41	ARPC4	ARPC4	ARPC4	9863	-0.017	0.32	NO
42	MAP2K4	MAP2K4	MAP2K4	10493	-0.026	0.29	NO
43	MAPK14	MAPK14	MAPK14	10638	-0.028	0.29	NO
44	STAT5A	STAT5A	STAT5A	10663	-0.028	0.29	NO
45	ABI2	ABI2	ABI2	10913	-0.032	0.28	NO
46	PIP5K1A	PIP5K1A	PIP5K1A	11318	-0.038	0.27	NO
47	PAK2	PAK2	PAK2	11409	-0.039	0.28	NO
48	ARHGDIA	ARHGDIA	ARHGDIA	11764	-0.045	0.27	NO
49	WASF2	WASF2	WASF2	12283	-0.054	0.25	NO
50	BAIAP2	BAIAP2	BAIAP2	13585	-0.08	0.2	NO
51	ATF2	ATF2	ATF2	14231	-0.099	0.18	NO
52	LIMK1	LIMK1	LIMK1	14380	-0.1	0.2	NO
53	PLCB2	PLCB2	PLCB2	15223	-0.14	0.18	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	TFAP2C	TFAP2C	TFAP2C	53	0.73	0.074	YES
2	S100A2	S100A2	S100A2	95	0.66	0.14	YES
3	ITGB4	ITGB4	ITGB4	142	0.6	0.2	YES
4	PERP	PERP	PERP	269	0.52	0.25	YES
5	VDR	VDR	VDR	312	0.5	0.3	YES
6	CLCA2	CLCA2	CLCA2	314	0.5	0.35	YES
7	EVPL	EVPL	EVPL	352	0.48	0.4	YES
8	SERPINB5	SERPINB5	SERPINB5	656	0.38	0.43	YES
9	SPATA18	SPATA18	SPATA18	944	0.32	0.44	YES
10	FAS	FAS	FAS	1047	0.31	0.47	YES
11	GDF15	GDF15	GDF15	1085	0.3	0.5	YES
12	NQO1	NQO1	NQO1	1106	0.3	0.53	YES
13	ITGA3	ITGA3	ITGA3	1746	0.23	0.52	YES
14	WWP1	WWP1	WWP1	1807	0.22	0.54	YES
15	PRKCD	PRKCD	PRKCD	1829	0.22	0.56	YES
16	DHRS3	DHRS3	DHRS3	2012	0.21	0.58	YES
17	DST	DST	DST	2356	0.18	0.58	YES
18	IGFBP3	IGFBP3	IGFBP3	2642	0.16	0.58	YES
19	JAG1	JAG1	JAG1	2772	0.15	0.59	YES
20	CABLES1	CABLES1	CABLES1	3320	0.13	0.57	NO
21	PML	PML	PML	4176	0.093	0.54	NO
22	MFGE8	MFGE8	MFGE8	4293	0.088	0.54	NO
23	TP53I3	TP53I3	TP53I3	4471	0.083	0.54	NO
24	IKBKB	IKBKB	IKBKB	4540	0.081	0.54	NO
25	GADD45A	GADD45A	GADD45A	4652	0.078	0.55	NO
26	BAX	BAX	BAX	5299	0.061	0.52	NO
27	YWHAQ	YWHAQ	YWHAQ	5622	0.055	0.51	NO
28	BBC3	BBC3	BBC3	6046	0.046	0.49	NO
29	TRAF4	TRAF4	TRAF4	6275	0.041	0.48	NO
30	HBP1	HBP1	HBP1	6321	0.04	0.48	NO
31	EGR2	EGR2	EGR2	6662	0.034	0.47	NO
32	FDXR	FDXR	FDXR	6878	0.03	0.46	NO
33	MDM2	MDM2	MDM2	7398	0.02	0.43	NO
34	CDKN1A	CDKN1A	CDKN1A	7661	0.016	0.42	NO
35	SP1	SP1	SP1	9053	-0.0054	0.35	NO
36	EP300	EP300	EP300	9294	-0.0087	0.34	NO
37	SHH	SHH	SHH	10362	-0.024	0.28	NO
38	CHUK	CHUK	CHUK	10701	-0.029	0.26	NO
39	ITCH	ITCH	ITCH	10934	-0.032	0.26	NO
40	FLOT2	FLOT2	FLOT2	11077	-0.034	0.25	NO
41	GPX2	GPX2	GPX2	11592	-0.042	0.23	NO
42	DICER1	DICER1	DICER1	12080	-0.051	0.21	NO
43	ABL1	ABL1	ABL1	12129	-0.051	0.21	NO
44	TP63	TP63	TP63	12391	-0.056	0.2	NO
45	PMAIP1	PMAIP1	PMAIP1	12764	-0.063	0.19	NO
46	SSRP1	SSRP1	SSRP1	12957	-0.067	0.19	NO
47	CDKN2A	CDKN2A	CDKN2A	13381	-0.076	0.17	NO
48	PLK1	PLK1	PLK1	13789	-0.086	0.16	NO
49	OGG1	OGG1	OGG1	13823	-0.086	0.17	NO
50	NOC2L	NOC2L	NOC2L	14609	-0.11	0.14	NO
51	AEN	AEN	AEN	15072	-0.13	0.12	NO
52	SMARCD3	SMARCD3	SMARCD3	15515	-0.15	0.12	NO
53	ADA	ADA	ADA	16735	-0.24	0.076	NO
54	SSPO	SSPO	SSPO	16813	-0.25	0.099	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	TLR3	TLR3	TLR3	192	0.57	0.032	YES
2	RPS6KA5	RPS6KA5	RPS6KA5	489	0.43	0.049	YES
3	MAPK10	MAPK10	MAPK10	543	0.42	0.077	YES
4	TLR5	TLR5	TLR5	654	0.38	0.1	YES
5	SAA1	SAA1	SAA1	669	0.38	0.13	YES
6	TLR1	TLR1	TLR1	684	0.38	0.16	YES
7	S100B	S100B	S100B	913	0.33	0.17	YES
8	CTSK	CTSK	CTSK	1142	0.3	0.18	YES
9	FOS	FOS	FOS	1151	0.29	0.2	YES
10	SIGIRR	SIGIRR	SIGIRR	1176	0.29	0.22	YES
11	RPS6KA2	RPS6KA2	RPS6KA2	1197	0.29	0.24	YES
12	IRF7	IRF7	IRF7	1228	0.28	0.26	YES
13	UNC93B1	UNC93B1	UNC93B1	1351	0.27	0.27	YES
14	TLR4	TLR4	TLR4	1437	0.26	0.29	YES
15	TICAM2	TICAM2	TICAM2	1464	0.26	0.31	YES
16	TICAM1	TICAM1	TICAM1	1475	0.26	0.33	YES
17	DUSP4	DUSP4	DUSP4	1785	0.23	0.33	YES
18	TLR7	TLR7	TLR7	1890	0.22	0.34	YES
19	TLR2	TLR2	TLR2	1903	0.22	0.35	YES
20	CD180	CD180	CD180	1950	0.21	0.36	YES
21	PELI2	PELI2	PELI2	1977	0.21	0.38	YES
22	CTSS	CTSS	CTSS	2214	0.19	0.38	YES
23	MAP2K6	MAP2K6	MAP2K6	2265	0.19	0.39	YES
24	RIPK2	RIPK2	RIPK2	2307	0.18	0.4	YES
25	RPS6KA1	RPS6KA1	RPS6KA1	2317	0.18	0.42	YES
26	PLCG2	PLCG2	PLCG2	2323	0.18	0.43	YES
27	IKBKE	IKBKE	IKBKE	2456	0.17	0.44	YES
28	NFKBIA	NFKBIA	NFKBIA	2493	0.17	0.45	YES
29	TLR6	TLR6	TLR6	2576	0.16	0.46	YES
30	CTSB	CTSB	CTSB	2598	0.16	0.47	YES
31	CD14	CD14	CD14	2691	0.16	0.47	YES
32	LY86	LY86	LY86	2722	0.16	0.48	YES
33	MYD88	MYD88	MYD88	2798	0.15	0.49	YES
34	IRAK2	IRAK2	IRAK2	2966	0.14	0.49	YES
35	MAP3K1	MAP3K1	MAP3K1	3055	0.14	0.5	YES
36	IRAK4	IRAK4	IRAK4	3421	0.12	0.49	YES
37	MAP2K3	MAP2K3	MAP2K3	3544	0.12	0.49	YES
38	BTK	BTK	BTK	3551	0.12	0.5	YES
39	PPP2CB	PPP2CB	PPP2CB	3717	0.11	0.5	YES
40	JUN	JUN	JUN	3757	0.11	0.5	YES
41	TLR8	TLR8	TLR8	3808	0.1	0.51	YES
42	TLR10	TLR10	TLR10	3828	0.1	0.52	YES
43	DUSP6	DUSP6	DUSP6	4168	0.093	0.5	NO
44	IKBKB	IKBKB	IKBKB	4540	0.081	0.49	NO
45	TLR9	TLR9	TLR9	4651	0.078	0.49	NO
46	LY96	LY96	LY96	4852	0.072	0.48	NO
47	RIPK1	RIPK1	RIPK1	4869	0.072	0.49	NO
48	PPP2R1B	PPP2R1B	PPP2R1B	5137	0.065	0.48	NO
49	APP	APP	APP	5186	0.064	0.48	NO
50	LGMN	LGMN	LGMN	5837	0.05	0.45	NO
51	TRAF6	TRAF6	TRAF6	6010	0.046	0.44	NO
52	TMEM189-UBE2V1	TMEM189-UBE2V1	TMEM189-UBE2V1	6188	0.043	0.44	NO
53	CREB1	CREB1	CREB1	6264	0.041	0.44	NO
54	IRF3	IRF3	IRF3	6717	0.033	0.42	NO
55	TIRAP	TIRAP	TIRAP	6832	0.031	0.41	NO
56	UBA52	UBA52	UBA52	7115	0.025	0.4	NO
57	MAPKAPK2	MAPKAPK2	MAPKAPK2	7143	0.025	0.4	NO
58	UBE2N	UBE2N	UBE2N	7390	0.02	0.39	NO
59	PELI1	PELI1	PELI1	7593	0.017	0.38	NO
60	NOD2	NOD2	NOD2	7889	0.013	0.36	NO
61	IKBKG	IKBKG	IKBKG	8001	0.011	0.36	NO
62	RELA	RELA	RELA	8074	0.01	0.35	NO
63	NOD1	NOD1	NOD1	8094	0.0096	0.35	NO
64	LBP	LBP	LBP	8140	0.0087	0.35	NO
65	PPP2CA	PPP2CA	PPP2CA	8313	0.006	0.34	NO
66	MAPK3	MAPK3	MAPK3	8354	0.0053	0.34	NO
67	MAP2K7	MAP2K7	MAP2K7	8526	0.003	0.33	NO
68	TBK1	TBK1	TBK1	8710	0.00027	0.32	NO
69	PPP2R1A	PPP2R1A	PPP2R1A	8782	-0.00082	0.32	NO
70	HSP90B1	HSP90B1	HSP90B1	9034	-0.0052	0.3	NO
71	TAB2	TAB2	TAB2	9183	-0.0072	0.3	NO
72	MAPK9	MAPK9	MAPK9	9190	-0.0073	0.3	NO
73	IRAK1	IRAK1	IRAK1	9233	-0.0078	0.3	NO
74	MAPK8	MAPK8	MAPK8	9321	-0.0091	0.29	NO
75	DNM2	DNM2	DNM2	9573	-0.013	0.28	NO
76	TRAF3	TRAF3	TRAF3	9662	-0.014	0.28	NO
77	DUSP3	DUSP3	DUSP3	9886	-0.017	0.26	NO
78	CDK1	CDK1	CDK1	10001	-0.019	0.26	NO
79	HMGB1	HMGB1	HMGB1	10049	-0.02	0.26	NO
80	MAP2K2	MAP2K2	MAP2K2	10081	-0.02	0.26	NO
81	PIK3R4	PIK3R4	PIK3R4	10104	-0.02	0.26	NO
82	PIK3C3	PIK3C3	PIK3C3	10274	-0.022	0.25	NO
83	CNPY3	CNPY3	CNPY3	10396	-0.024	0.25	NO
84	MAP2K4	MAP2K4	MAP2K4	10493	-0.026	0.24	NO
85	MAPK14	MAPK14	MAPK14	10638	-0.028	0.24	NO
86	CHUK	CHUK	CHUK	10701	-0.029	0.24	NO
87	ZFYVE20	ZFYVE20	ZFYVE20	10830	-0.031	0.23	NO
88	ECSIT	ECSIT	ECSIT	10956	-0.032	0.23	NO
89	MAPK1	MAPK1	MAPK1	11100	-0.035	0.22	NO
90	MAPK7	MAPK7	MAPK7	11257	-0.037	0.22	NO
91	EEA1	EEA1	EEA1	11361	-0.038	0.22	NO
92	PELI3	PELI3	PELI3	11460	-0.04	0.21	NO
93	TAB1	TAB1	TAB1	11475	-0.04	0.22	NO
94	CTSL1	CTSL1	CTSL1	11498	-0.041	0.22	NO
95	RPS27A	RPS27A	RPS27A	11845	-0.046	0.2	NO
96	PPP2R5D	PPP2R5D	PPP2R5D	11947	-0.048	0.2	NO
97	MAPK11	MAPK11	MAPK11	11967	-0.048	0.2	NO
98	MAPKAPK3	MAPKAPK3	MAPKAPK3	12047	-0.05	0.2	NO
99	TAB3	TAB3	TAB3	12152	-0.052	0.2	NO
100	NFKB2	NFKB2	NFKB2	12851	-0.065	0.17	NO
101	MEF2A	MEF2A	MEF2A	12921	-0.067	0.17	NO
102	RPS6KA3	RPS6KA3	RPS6KA3	12945	-0.067	0.17	NO
103	ELK1	ELK1	ELK1	13429	-0.077	0.15	NO
104	MAP2K1	MAP2K1	MAP2K1	13529	-0.079	0.15	NO
105	S100A12	S100A12	S100A12	13695	-0.083	0.15	NO
106	MAP3K7	MAP3K7	MAP3K7	13740	-0.084	0.15	NO
107	ATF2	ATF2	ATF2	14231	-0.099	0.14	NO
108	ATF1	ATF1	ATF1	15089	-0.13	0.099	NO
109	DUSP7	DUSP7	DUSP7	15224	-0.14	0.1	NO
110	AGER	AGER	AGER	15246	-0.14	0.11	NO
111	DNM1	DNM1	DNM1	15457	-0.15	0.11	NO
112	NFKBIB	NFKBIB	NFKBIB	16249	-0.2	0.083	NO
113	MEF2C	MEF2C	MEF2C	16865	-0.25	0.069	NO
114	IRAK3	IRAK3	IRAK3	17737	-0.36	0.049	NO

Fold change

For the top enriched genes, if you want to check whether they are

up-regulated, please check the list of up-regulated genes
down-regulated, please check the list of down-regulated genes

Expression level

For the top enriched genes, if you want to check whether they are

highly expressed genes, please check the list of high (top 30%) expressed genes
low expressed genes, please check the list of low (bottom 30%) expressed genes

An expression pattern of top(30%)/middle(30%)/low(30%) in this subtype against other subtypes is available in a heatmap

Significant gene list

For the top enriched genes, if you want to check whether they are

significantly differently expressed genes by eBayes lm fit, please check the list of significant genes

+ Subtype clus3 enriched pathways

Table 5. Get Full Table This table shows top 10 pathways which are significantly enriched in cluster clus3. It displays only significant gene sets satisfying nom.p.val.threshold (-1), fwer.p.val.threshold (-1) , fdr.q.val.threshold (0.25) and the default table is sorted by Normalized Enrichment Score (NES). Further details on NES statistics, please visit The Broad GSEA website.

GeneSet(GS)	Size(#genes)	genes.ES.table	ES	NES	NOM.p.val	FDR.q.val	FWER.p.val	Tag..	Gene..	Signal	FDR..median.	glob.p.val
KEGG SELENOAMINO ACID METABOLISM	26	genes.ES.table	0.45	1.5	0.099	1	0.98	0.46	0.35	0.3	1	0.61
KEGG STARCH AND SUCROSE METABOLISM	40	genes.ES.table	0.62	1.6	0.017	1	0.9	0.28	0.072	0.26	1	0.55
KEGG BUTANOATE METABOLISM	32	genes.ES.table	0.51	1.5	0.064	1	0.98	0.19	0.03	0.18	1	0.64
KEGG RETINOL METABOLISM	53	genes.ES.table	0.67	1.7	0.0024	1	0.86	0.4	0.077	0.37	1	0.68
KEGG PORPHYRIN AND CHLOROPHYLL METABOLISM	32	genes.ES.table	0.59	1.6	0.03	1	0.91	0.22	0.06	0.21	0.91	0.47
KEGG METABOLISM OF XENOBIOTICS BY CYTOCHROME P450	59	genes.ES.table	0.58	1.5	0.03	1	0.98	0.36	0.1	0.32	1	0.62
KEGG DRUG METABOLISM CYTOCHROME P450	60	genes.ES.table	0.58	1.5	0.039	1	0.98	0.35	0.1	0.32	1	0.58
SIG IL4RECEPTOR IN B LYPHOCYTES	27	genes.ES.table	0.53	1.7	0.012	1	0.76	0.22	0.091	0.2	1	0.69
ST INTERLEUKIN 4 PATHWAY	25	genes.ES.table	0.54	1.5	0.082	1	0.98	0.16	0.09	0.15	1	0.56
PID CD40 PATHWAY	30	genes.ES.table	0.55	1.5	0.11	1	0.98	0.2	0.079	0.18	1	0.64

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	IRS2	IRS2	IRS2	554	0.38	0.1	YES
2	MAP4K1	MAP4K1	MAP4K1	923	0.32	0.2	YES
3	SOCS1	SOCS1	SOCS1	958	0.32	0.3	YES
4	JAK3	JAK3	JAK3	1242	0.28	0.39	YES
5	STAT6	STAT6	STAT6	1675	0.24	0.45	YES
6	PIK3CD	PIK3CD	PIK3CD	1700	0.24	0.53	YES
7	IRS1	IRS1	IRS1	5223	0.083	0.37	NO
8	BAD	BAD	BAD	5554	0.076	0.37	NO
9	AKT3	AKT3	AKT3	5914	0.068	0.38	NO
10	SHC1	SHC1	SHC1	6345	0.06	0.38	NO
11	GRB2	GRB2	GRB2	6372	0.059	0.4	NO
12	MAPK3	MAPK3	MAPK3	7317	0.043	0.36	NO
13	GSK3A	GSK3A	GSK3A	7407	0.042	0.37	NO
14	SOS1	SOS1	SOS1	7483	0.04	0.38	NO
15	IL4R	IL4R	IL4R	7599	0.039	0.39	NO
16	AKT2	AKT2	AKT2	9450	0.012	0.29	NO
17	PPP1R13B	PPP1R13B	PPP1R13B	9962	0.0056	0.26	NO
18	JAK1	JAK1	JAK1	10025	0.0046	0.26	NO
19	MAPK1	MAPK1	MAPK1	10537	-0.0028	0.24	NO
20	SOS2	SOS2	SOS2	10691	-0.0052	0.23	NO
21	AKT1	AKT1	AKT1	12373	-0.031	0.15	NO
22	PDK1	PDK1	PDK1	12656	-0.036	0.15	NO
23	GSK3B	GSK3B	GSK3B	13441	-0.05	0.12	NO
24	RAF1	RAF1	RAF1	13977	-0.06	0.12	NO
25	PIK3R1	PIK3R1	PIK3R1	15032	-0.088	0.089	NO
26	PIK3CA	PIK3CA	PIK3CA	15343	-0.098	0.11	NO
27	BCL2	BCL2	BCL2	17234	-0.21	0.076	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	UGT2A3	UGT2A3	UGT2A3	51	0.71	0.06	YES
2	CYP2B6	CYP2B6	CYP2B6	54	0.7	0.12	YES
3	UGT2B10	UGT2B10	UGT2B10	145	0.56	0.17	YES
4	UGT2B7	UGT2B7	UGT2B7	163	0.54	0.21	YES
5	CYP26C1	CYP26C1	CYP26C1	316	0.46	0.24	YES
6	UGT2B15	UGT2B15	UGT2B15	399	0.43	0.28	YES
7	UGT1A6	UGT1A6	UGT1A6	429	0.42	0.31	YES
8	CYP3A5	CYP3A5	CYP3A5	489	0.4	0.35	YES
9	BCMO1	BCMO1	BCMO1	492	0.4	0.38	YES
10	CYP2C18	CYP2C18	CYP2C18	504	0.4	0.42	YES
11	ALDH1A1	ALDH1A1	ALDH1A1	728	0.35	0.44	YES
12	UGT1A9	UGT1A9	UGT1A9	743	0.35	0.47	YES
13	CYP2C9	CYP2C9	CYP2C9	764	0.35	0.5	YES
14	ALDH1A2	ALDH1A2	ALDH1A2	810	0.34	0.52	YES
15	ADH1B	ADH1B	ADH1B	831	0.34	0.55	YES
16	CYP26A1	CYP26A1	CYP26A1	881	0.33	0.58	YES
17	ADH6	ADH6	ADH6	997	0.32	0.6	YES
18	UGT2B11	UGT2B11	UGT2B11	1124	0.3	0.62	YES
19	ADH1C	ADH1C	ADH1C	1355	0.27	0.63	YES
20	RDH16	RDH16	RDH16	1362	0.27	0.65	YES
21	CYP3A7	CYP3A7	CYP3A7	1433	0.26	0.67	YES
22	ADH1A	ADH1A	ADH1A	2427	0.19	0.64	NO
23	UGT1A1	UGT1A1	UGT1A1	4115	0.11	0.56	NO
24	CYP4A11	CYP4A11	CYP4A11	4329	0.1	0.55	NO
25	RPE65	RPE65	RPE65	4557	0.099	0.55	NO
26	CYP4A22	CYP4A22	CYP4A22	4975	0.089	0.54	NO
27	CYP2C8	CYP2C8	CYP2C8	5332	0.08	0.52	NO
28	RDH5	RDH5	RDH5	6130	0.064	0.49	NO
29	RETSAT	RETSAT	RETSAT	6616	0.055	0.46	NO
30	RDH8	RDH8	RDH8	6647	0.055	0.47	NO
31	UGT2B4	UGT2B4	UGT2B4	6706	0.054	0.47	NO
32	DGAT2	DGAT2	DGAT2	6735	0.053	0.47	NO
33	CYP3A43	CYP3A43	CYP3A43	7844	0.035	0.42	NO
34	CYP1A2	CYP1A2	CYP1A2	9825	0.0071	0.31	NO
35	DHRS3	DHRS3	DHRS3	10347	-0.00022	0.28	NO
36	DGAT1	DGAT1	DGAT1	10602	-0.0038	0.27	NO
37	RDH10	RDH10	RDH10	11444	-0.016	0.23	NO
38	ADH5	ADH5	ADH5	11562	-0.018	0.22	NO
39	LRAT	LRAT	LRAT	11667	-0.02	0.22	NO
40	DHRS4	DHRS4	DHRS4	11812	-0.022	0.21	NO
41	PNPLA4	PNPLA4	PNPLA4	11903	-0.024	0.21	NO
42	ADH4	ADH4	ADH4	12130	-0.027	0.2	NO
43	CYP2A13	CYP2A13	CYP2A13	12231	-0.029	0.2	NO
44	RDH11	RDH11	RDH11	13956	-0.06	0.11	NO
45	DHRS9	DHRS9	DHRS9	14422	-0.071	0.09	NO
46	DHRS4L2	DHRS4L2	DHRS4L2	14607	-0.076	0.086	NO
47	CYP3A4	CYP3A4	CYP3A4	14667	-0.078	0.09	NO
48	CYP26B1	CYP26B1	CYP26B1	15675	-0.11	0.046	NO
49	UGT2A1	UGT2A1	UGT2A1	17380	-0.22	-0.026	NO
50	CYP2A6	CYP2A6	CYP2A6	17405	-0.23	-0.0075	NO
51	CYP1A1	CYP1A1	CYP1A1	17540	-0.24	0.0068	NO
52	RDH12	RDH12	RDH12	17774	-0.28	0.018	NO
53	AWAT2	AWAT2	AWAT2	18047	-0.32	0.032	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	NMNAT2	NMNAT2	NMNAT2	202	0.52	0.076	YES
2	SLC19A3	SLC19A3	SLC19A3	431	0.42	0.13	YES
3	TPK1	TPK1	TPK1	564	0.38	0.19	YES
4	QPRT	QPRT	QPRT	953	0.32	0.22	YES
5	SLC23A1	SLC23A1	SLC23A1	1475	0.26	0.24	YES
6	GSTO2	GSTO2	GSTO2	1814	0.23	0.26	YES
7	CYB5A	CYB5A	CYB5A	2553	0.18	0.25	YES
8	PNPO	PNPO	PNPO	2593	0.18	0.28	YES
9	NADSYN1	NADSYN1	NADSYN1	2673	0.17	0.3	YES
10	SHMT1	SHMT1	SHMT1	2773	0.17	0.33	YES
11	SLC5A6	SLC5A6	SLC5A6	2987	0.16	0.34	YES
12	PPCDC	PPCDC	PPCDC	3241	0.14	0.35	YES
13	FASN	FASN	FASN	3324	0.14	0.37	YES
14	MOCS3	MOCS3	MOCS3	3375	0.14	0.39	YES
15	SLC2A3	SLC2A3	SLC2A3	3595	0.13	0.4	YES
16	PANK1	PANK1	PANK1	3608	0.13	0.42	YES
17	SLC46A1	SLC46A1	SLC46A1	3685	0.13	0.44	YES
18	SLC19A2	SLC19A2	SLC19A2	4336	0.1	0.42	NO
19	SLC2A1	SLC2A1	SLC2A1	4749	0.094	0.42	NO
20	NADK	NADK	NADK	4899	0.091	0.42	NO
21	SLC19A1	SLC19A1	SLC19A1	5305	0.081	0.42	NO
22	COASY	COASY	COASY	5334	0.08	0.43	NO
23	GPHN	GPHN	GPHN	6018	0.066	0.4	NO
24	AASDHPPT	AASDHPPT	AASDHPPT	6079	0.064	0.41	NO
25	FLAD1	FLAD1	FLAD1	6277	0.061	0.41	NO
26	RFK	RFK	RFK	6282	0.061	0.42	NO
27	SLC25A16	SLC25A16	SLC25A16	6690	0.054	0.41	NO
28	GSTO1	GSTO1	GSTO1	7015	0.048	0.4	NO
29	MTHFR	MTHFR	MTHFR	7117	0.047	0.4	NO
30	NMNAT3	NMNAT3	NMNAT3	7181	0.046	0.4	NO
31	FPGS	FPGS	FPGS	7474	0.041	0.4	NO
32	NFS1	NFS1	NFS1	7890	0.034	0.38	NO
33	ACP5	ACP5	ACP5	8932	0.019	0.32	NO
34	NMNAT1	NMNAT1	NMNAT1	9101	0.016	0.32	NO
35	SLC23A2	SLC23A2	SLC23A2	10079	0.0039	0.27	NO
36	PPCS	PPCS	PPCS	10789	-0.0066	0.23	NO
37	PANK2	PANK2	PANK2	10933	-0.0089	0.22	NO
38	DHFR	DHFR	DHFR	11454	-0.016	0.2	NO
39	PDXK	PDXK	PDXK	11623	-0.019	0.19	NO
40	PANK4	PANK4	PANK4	11710	-0.02	0.19	NO
41	CYB5R3	CYB5R3	CYB5R3	12073	-0.026	0.18	NO
42	THTPA	THTPA	THTPA	12553	-0.034	0.16	NO
43	PANK3	PANK3	PANK3	12884	-0.04	0.15	NO
44	MTHFD1	MTHFD1	MTHFD1	13512	-0.051	0.12	NO
45	NAMPT	NAMPT	NAMPT	14046	-0.062	0.1	NO
46	MOCS2	MOCS2	MOCS2	15764	-0.11	0.029	NO
47	SLC25A32	SLC25A32	SLC25A32	16076	-0.13	0.034	NO
48	ENPP1	ENPP1	ENPP1	16263	-0.14	0.048	NO
49	MOCS1	MOCS1	MOCS1	16786	-0.17	0.048	NO
50	MOCOS	MOCOS	MOCOS	17968	-0.31	0.036	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	SULT1C2	SULT1C2	SULT1C2	53	0.7	0.071	YES
2	GLYAT	GLYAT	GLYAT	102	0.6	0.13	YES
3	UGT2B10	UGT2B10	UGT2B10	145	0.56	0.19	YES
4	UGT2B7	UGT2B7	UGT2B7	163	0.54	0.24	YES
5	GGT1	GGT1	GGT1	338	0.45	0.28	YES
6	ACSM1	ACSM1	ACSM1	347	0.45	0.33	YES
7	UGT1A6	UGT1A6	UGT1A6	429	0.42	0.37	YES
8	MAT1A	MAT1A	MAT1A	433	0.42	0.41	YES
9	SULT1E1	SULT1E1	SULT1E1	482	0.4	0.45	YES
10	UGT1A9	UGT1A9	UGT1A9	743	0.35	0.48	YES
11	SULT1C4	SULT1C4	SULT1C4	994	0.32	0.5	YES
12	UGT2B11	UGT2B11	UGT2B11	1124	0.3	0.52	YES
13	GSTA1	GSTA1	GSTA1	1633	0.25	0.52	YES
14	MGST1	MGST1	MGST1	1649	0.24	0.55	YES
15	GSTO2	GSTO2	GSTO2	1814	0.23	0.56	YES
16	GSTA2	GSTA2	GSTA2	1942	0.22	0.58	YES
17	SULT1B1	SULT1B1	SULT1B1	2359	0.19	0.57	NO
18	SULT1A1	SULT1A1	SULT1A1	3427	0.14	0.53	NO
19	AHCY	AHCY	AHCY	3622	0.13	0.53	NO
20	SULT1A2	SULT1A2	SULT1A2	3631	0.13	0.55	NO
21	GSTM5	GSTM5	GSTM5	3747	0.12	0.55	NO
22	UGT1A1	UGT1A1	UGT1A1	4115	0.11	0.55	NO
23	CNDP2	CNDP2	CNDP2	4917	0.09	0.51	NO
24	GSS	GSS	GSS	5203	0.083	0.51	NO
25	MAT2A	MAT2A	MAT2A	5277	0.082	0.51	NO
26	GSTP1	GSTP1	GSTP1	5394	0.079	0.51	NO
27	UGDH	UGDH	UGDH	5637	0.074	0.51	NO
28	SULT1A3	SULT1A3	SULT1A3	6027	0.065	0.49	NO
29	PAPSS1	PAPSS1	PAPSS1	6243	0.062	0.49	NO
30	NAT2	NAT2	NAT2	6626	0.055	0.47	NO
31	UGT2B4	UGT2B4	UGT2B4	6706	0.054	0.48	NO
32	GSTO1	GSTO1	GSTO1	7015	0.048	0.46	NO
33	MAT2B	MAT2B	MAT2B	7707	0.037	0.43	NO
34	TPMT	TPMT	TPMT	7990	0.032	0.42	NO
35	BPNT1	BPNT1	BPNT1	8029	0.032	0.42	NO
36	MTR	MTR	MTR	8261	0.028	0.41	NO
37	GSTM4	GSTM4	GSTM4	8357	0.027	0.41	NO
38	GCLC	GCLC	GCLC	8955	0.019	0.38	NO
39	MGST3	MGST3	MGST3	9084	0.017	0.37	NO
40	COMT	COMT	COMT	9663	0.0092	0.34	NO
41	CYP1A2	CYP1A2	CYP1A2	9825	0.0071	0.33	NO
42	MGST2	MGST2	MGST2	10236	0.0014	0.31	NO
43	NAT1	NAT1	NAT1	10570	-0.0034	0.3	NO
44	PAPSS2	PAPSS2	PAPSS2	10574	-0.0034	0.3	NO
45	GGCT	GGCT	GGCT	11191	-0.012	0.26	NO
46	GSTA4	GSTA4	GSTA4	11887	-0.024	0.23	NO
47	SULT2B1	SULT2B1	SULT2B1	12796	-0.038	0.18	NO
48	SULT4A1	SULT4A1	SULT4A1	12968	-0.041	0.18	NO
49	GGT7	GGT7	GGT7	13423	-0.049	0.16	NO
50	GCLM	GCLM	GCLM	13896	-0.059	0.14	NO
51	GGT5	GGT5	GGT5	14612	-0.076	0.11	NO
52	UGP2	UGP2	UGP2	14864	-0.083	0.1	NO
53	SLC35D1	SLC35D1	SLC35D1	15039	-0.088	0.1	NO
54	GSTA3	GSTA3	GSTA3	15652	-0.11	0.084	NO
55	GSTM1	GSTM1	GSTM1	16120	-0.13	0.072	NO
56	OPLAH	OPLAH	OPLAH	16983	-0.19	0.046	NO
57	NNMT	NNMT	NNMT	17056	-0.19	0.062	NO
58	UGT2A1	UGT2A1	UGT2A1	17380	-0.22	0.068	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	MGAM	MGAM	MGAM	43	0.72	0.09	YES
2	UGT2A3	UGT2A3	UGT2A3	51	0.71	0.18	YES
3	ENPP3	ENPP3	ENPP3	122	0.58	0.25	YES
4	UGT2B10	UGT2B10	UGT2B10	145	0.56	0.32	YES
5	UGT2B7	UGT2B7	UGT2B7	163	0.54	0.39	YES
6	AMY2B	AMY2B	AMY2B	194	0.52	0.46	YES
7	UGT2B15	UGT2B15	UGT2B15	399	0.43	0.5	YES
8	UGT1A6	UGT1A6	UGT1A6	429	0.42	0.56	YES
9	UGT1A9	UGT1A9	UGT1A9	743	0.35	0.58	YES
10	UGT2B11	UGT2B11	UGT2B11	1124	0.3	0.6	YES
11	AMY2A	AMY2A	AMY2A	1350	0.27	0.62	YES
12	UGT1A1	UGT1A1	UGT1A1	4115	0.11	0.49	NO
13	AMY1A	AMY1A	AMY1A	4118	0.11	0.5	NO
14	G6PC	G6PC	G6PC	4819	0.093	0.48	NO
15	GCK	GCK	GCK	4882	0.091	0.49	NO
16	HK3	HK3	HK3	5089	0.086	0.49	NO
17	HK2	HK2	HK2	5344	0.08	0.48	NO
18	UGDH	UGDH	UGDH	5637	0.074	0.48	NO
19	GAA	GAA	GAA	6302	0.061	0.45	NO
20	UGT2B4	UGT2B4	UGT2B4	6706	0.054	0.44	NO
21	UXS1	UXS1	UXS1	6736	0.053	0.44	NO
22	GPI	GPI	GPI	6899	0.05	0.44	NO
23	TREH	TREH	TREH	7079	0.048	0.44	NO
24	GBA3	GBA3	GBA3	7800	0.036	0.4	NO
25	PYGB	PYGB	PYGB	7904	0.034	0.4	NO
26	GYS1	GYS1	GYS1	8761	0.022	0.36	NO
27	GYS2	GYS2	GYS2	9444	0.012	0.32	NO
28	HK1	HK1	HK1	10455	-0.0018	0.27	NO
29	GANC	GANC	GANC	10524	-0.0026	0.26	NO
30	GUSB	GUSB	GUSB	11861	-0.023	0.2	NO
31	PYGM	PYGM	PYGM	14015	-0.061	0.087	NO
32	UGP2	UGP2	UGP2	14864	-0.083	0.052	NO
33	PGM2	PGM2	PGM2	15030	-0.088	0.055	NO
34	PGM1	PGM1	PGM1	15479	-0.1	0.044	NO
35	PGM2L1	PGM2L1	PGM2L1	15538	-0.11	0.055	NO
36	AGL	AGL	AGL	15901	-0.12	0.051	NO
37	ENPP1	ENPP1	ENPP1	16263	-0.14	0.049	NO
38	PYGL	PYGL	PYGL	16853	-0.18	0.04	NO
39	GBE1	GBE1	GBE1	17292	-0.21	0.044	NO
40	UGT2A1	UGT2A1	UGT2A1	17380	-0.22	0.068	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	CLDN19	CLDN19	CLDN19	35	0.75	0.11	YES
2	PARD6B	PARD6B	PARD6B	108	0.6	0.19	YES
3	CLDN2	CLDN2	CLDN2	172	0.54	0.27	YES
4	CLDN6	CLDN6	CLDN6	179	0.53	0.34	YES
5	CLDN11	CLDN11	CLDN11	222	0.5	0.42	YES
6	CRB3	CRB3	CRB3	459	0.42	0.46	YES
7	CLDN3	CLDN3	CLDN3	469	0.41	0.52	YES
8	CLDN7	CLDN7	CLDN7	1246	0.28	0.52	YES
9	PARD6A	PARD6A	PARD6A	1290	0.28	0.56	YES
10	CLDN4	CLDN4	CLDN4	1338	0.27	0.6	YES
11	CLDN20	CLDN20	CLDN20	1938	0.22	0.6	YES
12	CLDN9	CLDN9	CLDN9	2345	0.19	0.6	YES
13	CLDN14	CLDN14	CLDN14	2358	0.19	0.63	YES
14	CLDN18	CLDN18	CLDN18	2433	0.19	0.66	YES
15	F11R	F11R	F11R	2514	0.18	0.68	YES
16	INADL	INADL	INADL	2668	0.17	0.7	YES
17	CLDN8	CLDN8	CLDN8	3485	0.13	0.67	YES
18	CLDN1	CLDN1	CLDN1	3492	0.13	0.69	YES
19	CLDN16	CLDN16	CLDN16	3541	0.13	0.71	YES
20	CLDN15	CLDN15	CLDN15	3623	0.13	0.72	YES
21	PRKCI	PRKCI	PRKCI	5643	0.074	0.62	NO
22	CLDN12	CLDN12	CLDN12	6452	0.058	0.59	NO
23	MPP5	MPP5	MPP5	6532	0.056	0.59	NO
24	PARD3	PARD3	PARD3	9004	0.018	0.46	NO
25	PARD6G	PARD6G	PARD6G	14300	-0.068	0.19	NO
26	CLDN5	CLDN5	CLDN5	14453	-0.072	0.19	NO
27	CLDN10	CLDN10	CLDN10	17529	-0.24	0.06	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	UGT2A3	UGT2A3	UGT2A3	51	0.71	0.14	YES
2	UGT2B10	UGT2B10	UGT2B10	145	0.56	0.24	YES
3	UGT2B7	UGT2B7	UGT2B7	163	0.54	0.34	YES
4	UGT2B15	UGT2B15	UGT2B15	399	0.43	0.42	YES
5	UGT1A6	UGT1A6	UGT1A6	429	0.42	0.5	YES
6	UGT1A9	UGT1A9	UGT1A9	743	0.35	0.55	YES
7	UGT2B11	UGT2B11	UGT2B11	1124	0.3	0.59	YES
8	PPOX	PPOX	PPOX	2298	0.19	0.56	NO
9	ALAS2	ALAS2	ALAS2	3533	0.13	0.52	NO
10	UGT1A1	UGT1A1	UGT1A1	4115	0.11	0.51	NO
11	UGT2B4	UGT2B4	UGT2B4	6706	0.054	0.38	NO
12	CPOX	CPOX	CPOX	6905	0.05	0.38	NO
13	UROD	UROD	UROD	7371	0.042	0.36	NO
14	EARS2	EARS2	EARS2	7538	0.04	0.36	NO
15	HMBS	HMBS	HMBS	7776	0.036	0.36	NO
16	COX15	COX15	COX15	7830	0.035	0.36	NO
17	HMOX2	HMOX2	HMOX2	9059	0.017	0.3	NO
18	ALAD	ALAD	ALAD	10165	0.0026	0.24	NO
19	EPRS	EPRS	EPRS	11610	-0.019	0.17	NO
20	GUSB	GUSB	GUSB	11861	-0.023	0.16	NO
21	BLVRB	BLVRB	BLVRB	11969	-0.025	0.16	NO
22	FECH	FECH	FECH	12012	-0.026	0.16	NO
23	UROS	UROS	UROS	12175	-0.028	0.16	NO
24	COX10	COX10	COX10	12268	-0.03	0.16	NO
25	BLVRA	BLVRA	BLVRA	13408	-0.049	0.11	NO
26	FTH1	FTH1	FTH1	14256	-0.067	0.073	NO
27	MMAB	MMAB	MMAB	14953	-0.085	0.053	NO
28	ALAS1	ALAS1	ALAS1	15640	-0.11	0.037	NO
29	HMOX1	HMOX1	HMOX1	16008	-0.13	0.042	NO
30	HCCS	HCCS	HCCS	16305	-0.14	0.053	NO
31	CP	CP	CP	16423	-0.15	0.076	NO
32	UGT2A1	UGT2A1	UGT2A1	17380	-0.22	0.068	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	PLA2G4F	PLA2G4F	PLA2G4F	164	0.54	0.053	YES
2	SLC44A5	SLC44A5	SLC44A5	415	0.42	0.088	YES
3	SLC44A3	SLC44A3	SLC44A3	829	0.34	0.1	YES
4	LPIN3	LPIN3	LPIN3	920	0.32	0.14	YES
5	PLD4	PLD4	PLD4	1156	0.29	0.16	YES
6	GPD1	GPD1	GPD1	1464	0.26	0.17	YES
7	PLA2G3	PLA2G3	PLA2G3	1478	0.26	0.2	YES
8	CHAT	CHAT	CHAT	1697	0.24	0.21	YES
9	SLC44A4	SLC44A4	SLC44A4	1739	0.24	0.24	YES
10	PNPLA3	PNPLA3	PNPLA3	1982	0.22	0.25	YES
11	PCYT1B	PCYT1B	PCYT1B	2147	0.2	0.26	YES
12	CDS1	CDS1	CDS1	2327	0.19	0.28	YES
13	PLA2G4C	PLA2G4C	PLA2G4C	2389	0.19	0.3	YES
14	LPCAT3	LPCAT3	LPCAT3	2507	0.18	0.31	YES
15	LPCAT2	LPCAT2	LPCAT2	2606	0.18	0.32	YES
16	ETNK1	ETNK1	ETNK1	2607	0.18	0.34	YES
17	PLA2G1B	PLA2G1B	PLA2G1B	2669	0.17	0.36	YES
18	AGPAT2	AGPAT2	AGPAT2	2867	0.16	0.37	YES
19	PLA2G2D	PLA2G2D	PLA2G2D	2891	0.16	0.38	YES
20	PLBD1	PLBD1	PLBD1	2991	0.16	0.4	YES
21	CHKB	CHKB	CHKB	3160	0.15	0.4	YES
22	PLD2	PLD2	PLD2	3275	0.14	0.41	YES
23	PLA2G6	PLA2G6	PLA2G6	3834	0.12	0.4	NO
24	MBOAT7	MBOAT7	MBOAT7	3883	0.12	0.41	NO
25	PCYT2	PCYT2	PCYT2	4440	0.1	0.39	NO
26	PGS1	PGS1	PGS1	4510	0.1	0.4	NO
27	EPT1	EPT1	EPT1	4606	0.098	0.4	NO
28	TAZ	TAZ	TAZ	4986	0.089	0.39	NO
29	CHKA	CHKA	CHKA	5413	0.078	0.38	NO
30	CRLS1	CRLS1	CRLS1	5419	0.078	0.39	NO
31	PTDSS2	PTDSS2	PTDSS2	6292	0.061	0.35	NO
32	PLD3	PLD3	PLD3	6688	0.054	0.33	NO
33	DGAT2	DGAT2	DGAT2	6735	0.053	0.34	NO
34	LCLAT1	LCLAT1	LCLAT1	6804	0.052	0.34	NO
35	PEMT	PEMT	PEMT	6843	0.051	0.34	NO
36	AGPAT9	AGPAT9	AGPAT9	7011	0.048	0.34	NO
37	AGPAT1	AGPAT1	AGPAT1	7571	0.039	0.31	NO
38	ETNK2	ETNK2	ETNK2	7815	0.035	0.3	NO
39	MBOAT1	MBOAT1	MBOAT1	7901	0.034	0.3	NO
40	LPIN1	LPIN1	LPIN1	7979	0.032	0.3	NO
41	PNPLA2	PNPLA2	PNPLA2	8120	0.03	0.3	NO
42	CDIPT	CDIPT	CDIPT	8301	0.028	0.29	NO
43	PLA2G12A	PLA2G12A	PLA2G12A	8327	0.028	0.3	NO
44	GPAT2	GPAT2	GPAT2	8691	0.022	0.28	NO
45	HADHA	HADHA	HADHA	9355	0.013	0.24	NO
46	CDS2	CDS2	CDS2	9525	0.011	0.24	NO
47	PLA2G4D	PLA2G4D	PLA2G4D	9565	0.01	0.24	NO
48	LPCAT4	LPCAT4	LPCAT4	9765	0.0079	0.22	NO
49	CEPT1	CEPT1	CEPT1	9845	0.0068	0.22	NO
50	LPCAT1	LPCAT1	LPCAT1	9854	0.0067	0.22	NO
51	MBOAT2	MBOAT2	MBOAT2	9884	0.0064	0.22	NO
52	PITPNB	PITPNB	PITPNB	9947	0.0058	0.22	NO
53	AGPAT4	AGPAT4	AGPAT4	10020	0.0047	0.22	NO
54	PLA2G2F	PLA2G2F	PLA2G2F	10256	0.0011	0.2	NO
55	DGAT1	DGAT1	DGAT1	10602	-0.0038	0.18	NO
56	LPIN2	LPIN2	LPIN2	10725	-0.0057	0.18	NO
57	PLA2G5	PLA2G5	PLA2G5	10861	-0.0078	0.17	NO
58	GNPAT	GNPAT	GNPAT	10866	-0.0078	0.17	NO
59	PLA2G16	PLA2G16	PLA2G16	10905	-0.0084	0.17	NO
60	HADHB	HADHB	HADHB	11192	-0.013	0.16	NO
61	GPCPD1	GPCPD1	GPCPD1	11877	-0.023	0.12	NO
62	AGPAT3	AGPAT3	AGPAT3	11952	-0.025	0.12	NO
63	AGPAT6	AGPAT6	AGPAT6	12160	-0.028	0.11	NO
64	SLC44A1	SLC44A1	SLC44A1	12406	-0.032	0.1	NO
65	GPAM	GPAM	GPAM	12508	-0.034	0.1	NO
66	GPD1L	GPD1L	GPD1L	12547	-0.034	0.1	NO
67	AGPAT5	AGPAT5	AGPAT5	13114	-0.043	0.079	NO
68	PLD6	PLD6	PLD6	13164	-0.044	0.082	NO
69	MGLL	MGLL	MGLL	13760	-0.056	0.056	NO
70	CHPT1	CHPT1	CHPT1	14140	-0.065	0.043	NO
71	PCYT1A	PCYT1A	PCYT1A	14215	-0.066	0.046	NO
72	PTDSS1	PTDSS1	PTDSS1	14856	-0.082	0.021	NO
73	PLA2G10	PLA2G10	PLA2G10	14945	-0.085	0.026	NO
74	SLC44A2	SLC44A2	SLC44A2	15103	-0.09	0.028	NO
75	LPGAT1	LPGAT1	LPGAT1	15315	-0.098	0.028	NO
76	PNPLA8	PNPLA8	PNPLA8	15814	-0.12	0.014	NO
77	PLA2G4A	PLA2G4A	PLA2G4A	16563	-0.16	-0.0086	NO
78	PLD1	PLD1	PLD1	16642	-0.16	0.0056	NO
79	ACHE	ACHE	ACHE	16889	-0.18	0.012	NO
80	PLA2G2A	PLA2G2A	PLA2G2A	17607	-0.25	0.0024	NO
81	PHOSPHO1	PHOSPHO1	PHOSPHO1	18507	-0.47	0.0075	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	HNF4A	HNF4A	HNF4A	24	0.8	0.081	YES
2	HNF1B	HNF1B	HNF1B	33	0.75	0.16	YES
3	HNF1A	HNF1A	HNF1A	39	0.73	0.23	YES
4	AFP	AFP	AFP	149	0.55	0.28	YES
5	FOXA2	FOXA2	FOXA2	156	0.55	0.34	YES
6	FOXA3	FOXA3	FOXA3	270	0.48	0.38	YES
7	SLC2A2	SLC2A2	SLC2A2	278	0.48	0.43	YES
8	PCK1	PCK1	PCK1	336	0.45	0.47	YES
9	TTR	TTR	TTR	356	0.44	0.52	YES
10	PDX1	PDX1	PDX1	539	0.39	0.55	YES
11	F2	F2	F2	761	0.35	0.57	YES
12	ALB	ALB	ALB	974	0.32	0.59	YES
13	ALDOB	ALDOB	ALDOB	1035	0.31	0.62	YES
14	APOA1	APOA1	APOA1	1411	0.27	0.63	YES
15	NKX2-1	NKX2-1	NKX2-1	1890	0.22	0.63	NO
16	ABCC8	ABCC8	ABCC8	2257	0.2	0.63	NO
17	DLK1	DLK1	DLK1	2793	0.17	0.62	NO
18	PKLR	PKLR	PKLR	3260	0.14	0.6	NO
19	CPT1B	CPT1B	CPT1B	3314	0.14	0.62	NO
20	FOXA1	FOXA1	FOXA1	3822	0.12	0.6	NO
21	KCNJ11	KCNJ11	KCNJ11	3867	0.12	0.61	NO
22	G6PC	G6PC	G6PC	4819	0.093	0.57	NO
23	GCK	GCK	GCK	4882	0.091	0.58	NO
24	CPT1C	CPT1C	CPT1C	5800	0.07	0.53	NO
25	BDH1	BDH1	BDH1	6059	0.065	0.53	NO
26	NF1	NF1	NF1	6138	0.063	0.53	NO
27	CEBPB	CEBPB	CEBPB	7877	0.034	0.44	NO
28	SP1	SP1	SP1	8135	0.03	0.43	NO
29	ACADVL	ACADVL	ACADVL	8646	0.023	0.4	NO
30	CREB1	CREB1	CREB1	8746	0.022	0.4	NO
31	ACADM	ACADM	ACADM	9739	0.0081	0.35	NO
32	UCP2	UCP2	UCP2	9848	0.0068	0.34	NO
33	AKT1	AKT1	AKT1	12373	-0.031	0.21	NO
34	NR3C1	NR3C1	NR3C1	13695	-0.055	0.14	NO
35	IGFBP1	IGFBP1	IGFBP1	14340	-0.069	0.12	NO
36	CPT1A	CPT1A	CPT1A	14409	-0.071	0.12	NO
37	HMGCS1	HMGCS1	HMGCS1	14444	-0.072	0.13	NO
38	ALAS1	ALAS1	ALAS1	15640	-0.11	0.074	NO
39	TFRC	TFRC	TFRC	15857	-0.12	0.074	NO
40	CEBPA	CEBPA	CEBPA	15946	-0.12	0.082	NO
41	FOXF1	FOXF1	FOXF1	16126	-0.13	0.086	NO
42	HADH	HADH	HADH	16346	-0.14	0.088	NO
43	TAT	TAT	TAT	16714	-0.17	0.086	NO
44	CEBPD	CEBPD	CEBPD	16858	-0.18	0.096	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	PIP5K1B	PIP5K1B	PIP5K1B	905	0.33	0.036	YES
2	MAP3K1	MAP3K1	MAP3K1	1071	0.31	0.11	YES
3	CDH1	CDH1	CDH1	1385	0.27	0.16	YES
4	NOXA1	NOXA1	NOXA1	1493	0.26	0.22	YES
5	NCF1	NCF1	NCF1	1687	0.24	0.27	YES
6	CYFIP2	CYFIP2	CYFIP2	2718	0.17	0.26	YES
7	BAIAP2	BAIAP2	BAIAP2	3149	0.15	0.28	YES
8	NOXO1	NOXO1	NOXO1	3391	0.14	0.3	YES
9	PLCB2	PLCB2	PLCB2	3612	0.13	0.32	YES
10	MAP2K6	MAP2K6	MAP2K6	3690	0.13	0.35	YES
11	ABI1	ABI1	ABI1	4097	0.11	0.36	YES
12	MAP3K11	MAP3K11	MAP3K11	4136	0.11	0.38	YES
13	STAT5A	STAT5A	STAT5A	4575	0.098	0.39	YES
14	ABI2	ABI2	ABI2	4780	0.094	0.4	YES
15	ATF2	ATF2	ATF2	5350	0.08	0.39	YES
16	ARHGDIA	ARHGDIA	ARHGDIA	5490	0.077	0.4	YES
17	CYBA	CYBA	CYBA	6095	0.064	0.39	YES
18	CYBB	CYBB	CYBB	6157	0.063	0.4	YES
19	LIMK1	LIMK1	LIMK1	6209	0.062	0.41	YES
20	MAPK9	MAPK9	MAPK9	6555	0.056	0.41	YES
21	BCAR1	BCAR1	BCAR1	6644	0.055	0.42	YES
22	MAP2K3	MAP2K3	MAP2K3	7413	0.042	0.39	NO
23	JUN	JUN	JUN	7614	0.039	0.39	NO
24	NCKAP1	NCKAP1	NCKAP1	7762	0.036	0.39	NO
25	MAPK8	MAPK8	MAPK8	8122	0.03	0.38	NO
26	ACTR2	ACTR2	ACTR2	8578	0.024	0.36	NO
27	PAK1	PAK1	PAK1	8587	0.024	0.37	NO
28	ACTR3	ACTR3	ACTR3	8753	0.022	0.36	NO
29	WASF2	WASF2	WASF2	8941	0.019	0.36	NO
30	ARHGAP5	ARHGAP5	ARHGAP5	8968	0.018	0.36	NO
31	ARPC4	ARPC4	ARPC4	9088	0.017	0.36	NO
32	STAT3	STAT3	STAT3	9449	0.012	0.34	NO
33	PAK2	PAK2	PAK2	9457	0.012	0.34	NO
34	NCF2	NCF2	NCF2	9461	0.012	0.35	NO
35	ARPC2	ARPC2	ARPC2	9786	0.0076	0.33	NO
36	RAC1	RAC1	RAC1	9872	0.0065	0.33	NO
37	PIP5K1A	PIP5K1A	PIP5K1A	9990	0.0051	0.32	NO
38	CTNNA1	CTNNA1	CTNNA1	10148	0.0029	0.32	NO
39	MAP2K4	MAP2K4	MAP2K4	10421	-0.0013	0.3	NO
40	MAPK14	MAPK14	MAPK14	10652	-0.0046	0.29	NO
41	ARPC5	ARPC5	ARPC5	10855	-0.0076	0.28	NO
42	NOX1	NOX1	NOX1	11408	-0.016	0.26	NO
43	IQGAP1	IQGAP1	IQGAP1	11678	-0.02	0.25	NO
44	CFL1	CFL1	CFL1	11739	-0.021	0.25	NO
45	ARPC1B	ARPC1B	ARPC1B	12010	-0.026	0.24	NO
46	ARPC3	ARPC3	ARPC3	12359	-0.031	0.23	NO
47	IQGAP3	IQGAP3	IQGAP3	12515	-0.034	0.23	NO
48	MAP2K7	MAP2K7	MAP2K7	12578	-0.035	0.24	NO
49	PIP5K1C	PIP5K1C	PIP5K1C	12888	-0.04	0.23	NO
50	CTNNB1	CTNNB1	CTNNB1	13035	-0.042	0.23	NO
51	WASF1	WASF1	WASF1	13474	-0.05	0.22	NO
52	CRK	CRK	CRK	14814	-0.082	0.17	NO
53	RACGAP1	RACGAP1	RACGAP1	16017	-0.13	0.14	NO

Fold change

For the top enriched genes, if you want to check whether they are

up-regulated, please check the list of up-regulated genes
down-regulated, please check the list of down-regulated genes

Expression level

For the top enriched genes, if you want to check whether they are

highly expressed genes, please check the list of high (top 30%) expressed genes
low expressed genes, please check the list of low (bottom 30%) expressed genes

An expression pattern of top(30%)/middle(30%)/low(30%) in this subtype against other subtypes is available in a heatmap

Significant gene list

For the top enriched genes, if you want to check whether they are

significantly differently expressed genes by eBayes lm fit, please check the list of significant genes

+ Subtype clus4 enriched pathways

Table 6. Get Full Table This table shows top 10 pathways which are significantly enriched in cluster clus4. It displays only significant gene sets satisfying nom.p.val.threshold (-1), fwer.p.val.threshold (-1) , fdr.q.val.threshold (0.25) and the default table is sorted by Normalized Enrichment Score (NES). Further details on NES statistics, please visit The Broad GSEA website.

GeneSet(GS)	Size(#genes)	genes.ES.table	ES	NES	NOM.p.val	FDR.q.val	FWER.p.val	Tag..	Gene..	Signal	FDR..median.	glob.p.val
KEGG CELL CYCLE	118	genes.ES.table	0.36	1.6	0.042	0.75	0.88	0.42	0.28	0.3	0.34	0.2
ST WNT BETA CATENIN PATHWAY	33	genes.ES.table	0.54	1.5	0.065	0.84	0.97	0.42	0.21	0.34	0.53	0.28
PID AURORA B PATHWAY	39	genes.ES.table	0.45	1.6	0.079	0.77	0.91	0.51	0.24	0.39	0.39	0.22
PID PLK1 PATHWAY	45	genes.ES.table	0.53	1.8	0.032	1	0.58	0.44	0.19	0.36	0.33	0.25
PID FOXM1PATHWAY	39	genes.ES.table	0.41	1.6	0.028	0.9	0.96	0.56	0.3	0.4	0.52	0.27
PID AURORA A PATHWAY	31	genes.ES.table	0.51	2	0.008	0.75	0.22	0.39	0.24	0.29	0	0.12
REACTOME MEIOSIS	103	genes.ES.table	0.55	1.5	0.091	0.85	0.98	0.4	0.19	0.32	0.56	0.29
REACTOME CELL CYCLE	380	genes.ES.table	0.38	1.7	0.058	0.79	0.7	0.41	0.28	0.3	0.22	0.18
REACTOME SIGNALLING TO ERKS	36	genes.ES.table	0.42	1.5	0.067	0.88	0.96	0.33	0.22	0.26	0.53	0.28
REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS	25	genes.ES.table	0.59	1.5	0.024	0.89	0.97	0.56	0.19	0.45	0.54	0.3

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	CPEB1	CPEB1	CPEB1	190	0.4	0.17	YES
2	CENPA	CENPA	CENPA	1671	0.17	0.17	YES
3	TACC3	TACC3	TACC3	1783	0.16	0.24	YES
4	DLGAP5	DLGAP5	DLGAP5	1903	0.15	0.3	YES
5	TPX2	TPX2	TPX2	2356	0.13	0.34	YES
6	CDC25B	CDC25B	CDC25B	2737	0.11	0.37	YES
7	CKAP5	CKAP5	CKAP5	3043	0.1	0.4	YES
8	BIRC5	BIRC5	BIRC5	3259	0.096	0.43	YES
9	AURKA	AURKA	AURKA	3404	0.091	0.46	YES
10	PPP2R5D	PPP2R5D	PPP2R5D	3425	0.09	0.5	YES
11	TP53	TP53	TP53	4180	0.071	0.5	YES
12	FZR1	FZR1	FZR1	4517	0.064	0.51	YES
13	AURKB	AURKB	AURKB	5304	0.05	0.49	NO
14	RAN	RAN	RAN	5924	0.04	0.47	NO
15	GADD45A	GADD45A	GADD45A	6686	0.028	0.44	NO
16	RASA1	RASA1	RASA1	7097	0.022	0.43	NO
17	MDM2	MDM2	MDM2	7163	0.021	0.44	NO
18	TACC1	TACC1	TACC1	7171	0.021	0.45	NO
19	PRKACA	PRKACA	PRKACA	7253	0.02	0.45	NO
20	BRCA1	BRCA1	BRCA1	8211	0.0075	0.4	NO
21	AURKAIP1	AURKAIP1	AURKAIP1	8221	0.0074	0.41	NO
22	GSK3B	GSK3B	GSK3B	8251	0.007	0.41	NO
23	ARHGEF7	ARHGEF7	ARHGEF7	8636	0.002	0.39	NO
24	AKT1	AKT1	AKT1	8741	0.0005	0.38	NO
25	GIT1	GIT1	GIT1	8897	-0.0012	0.38	NO
26	PAK1	PAK1	PAK1	10096	-0.017	0.32	NO
27	NDEL1	NDEL1	NDEL1	10164	-0.017	0.32	NO
28	OAZ1	OAZ1	OAZ1	10458	-0.021	0.32	NO
29	NFKBIA	NFKBIA	NFKBIA	12284	-0.051	0.24	NO
30	TDRD7	TDRD7	TDRD7	13092	-0.067	0.23	NO
31	JUB	JUB	JUB	15597	-0.15	0.16	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	CLSPN	CLSPN	CLSPN	963	0.24	0.018	YES
2	NDC80	NDC80	NDC80	1594	0.17	0.035	YES
3	SGOL1	SGOL1	SGOL1	1937	0.15	0.061	YES
4	FBXO5	FBXO5	FBXO5	1950	0.15	0.1	YES
5	ERCC6L	ERCC6L	ERCC6L	2253	0.14	0.13	YES
6	CENPE	CENPE	CENPE	2266	0.14	0.17	YES
7	TPX2	TPX2	TPX2	2356	0.13	0.2	YES
8	KIF20A	KIF20A	KIF20A	2461	0.13	0.23	YES
9	PRC1	PRC1	PRC1	2605	0.12	0.26	YES
10	INCENP	INCENP	INCENP	2608	0.12	0.29	YES
11	CDC25B	CDC25B	CDC25B	2737	0.11	0.32	YES
12	ODF2	ODF2	ODF2	2847	0.11	0.35	YES
13	MLF1IP	MLF1IP	MLF1IP	3110	0.1	0.36	YES
14	GOLGA2	GOLGA2	GOLGA2	3182	0.098	0.39	YES
15	CDC20	CDC20	CDC20	3237	0.096	0.41	YES
16	CDC25C	CDC25C	CDC25C	3339	0.092	0.43	YES
17	SPC24	SPC24	SPC24	3390	0.091	0.46	YES
18	AURKA	AURKA	AURKA	3404	0.091	0.48	YES
19	BUB1	BUB1	BUB1	3429	0.09	0.51	YES
20	PLK1	PLK1	PLK1	3481	0.088	0.53	YES
21	NINL	NINL	NINL	4199	0.071	0.51	NO
22	FZR1	FZR1	FZR1	4517	0.064	0.52	NO
23	CDC14B	CDC14B	CDC14B	4749	0.06	0.52	NO
24	BUB1B	BUB1B	BUB1B	5954	0.039	0.47	NO
25	PLK1S1	PLK1S1	PLK1S1	5986	0.039	0.48	NO
26	PPP1R12A	PPP1R12A	PPP1R12A	6329	0.033	0.47	NO
27	STAG2	STAG2	STAG2	6410	0.032	0.47	NO
28	TUBG1	TUBG1	TUBG1	7135	0.022	0.44	NO
29	CCNB1	CCNB1	CCNB1	7358	0.019	0.44	NO
30	ECT2	ECT2	ECT2	7431	0.018	0.44	NO
31	PPP2CA	PPP2CA	PPP2CA	7776	0.014	0.42	NO
32	CDK1	CDK1	CDK1	7814	0.013	0.42	NO
33	NUDC	NUDC	NUDC	8273	0.0068	0.4	NO
34	FBXW11	FBXW11	FBXW11	8305	0.0063	0.4	NO
35	SSPO	SSPO	SSPO	9009	-0.0027	0.36	NO
36	PAK1	PAK1	PAK1	10096	-0.017	0.31	NO
37	GORASP1	GORASP1	GORASP1	10321	-0.019	0.3	NO
38	PPP2R1A	PPP2R1A	PPP2R1A	10379	-0.02	0.31	NO
39	PPP1CB	PPP1CB	PPP1CB	11004	-0.029	0.28	NO
40	WEE1	WEE1	WEE1	12424	-0.053	0.22	NO
41	RAB1A	RAB1A	RAB1A	12569	-0.056	0.23	NO
42	RHOA	RHOA	RHOA	13272	-0.071	0.21	NO
43	KIF2A	KIF2A	KIF2A	13302	-0.072	0.23	NO
44	ROCK2	ROCK2	ROCK2	13445	-0.075	0.25	NO
45	TPT1	TPT1	TPT1	14644	-0.11	0.22	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	CENPP	CENPP	CENPP	822	0.26	-0.0062	YES
2	NDC80	NDC80	NDC80	1594	0.17	-0.022	YES
3	CASC5	CASC5	CASC5	1596	0.17	0.0037	YES
4	CENPA	CENPA	CENPA	1671	0.17	0.025	YES
5	PPP2R5B	PPP2R5B	PPP2R5B	1760	0.16	0.044	YES
6	CENPO	CENPO	CENPO	1766	0.16	0.068	YES
7	SPC25	SPC25	SPC25	1778	0.16	0.091	YES
8	APITD1	APITD1	APITD1	1787	0.16	0.11	YES
9	SMC1A	SMC1A	SMC1A	1894	0.15	0.13	YES
10	KIF18A	KIF18A	KIF18A	1917	0.15	0.15	YES
11	SGOL1	SGOL1	SGOL1	1937	0.15	0.17	YES
12	CENPI	CENPI	CENPI	2215	0.14	0.18	YES
13	ERCC6L	ERCC6L	ERCC6L	2253	0.14	0.2	YES
14	SKA1	SKA1	SKA1	2322	0.13	0.21	YES
15	KIF2C	KIF2C	KIF2C	2488	0.12	0.22	YES
16	CDCA8	CDCA8	CDCA8	2515	0.12	0.24	YES
17	CENPQ	CENPQ	CENPQ	2532	0.12	0.26	YES
18	INCENP	INCENP	INCENP	2608	0.12	0.27	YES
19	NUF2	NUF2	NUF2	2651	0.12	0.29	YES
20	CENPL	CENPL	CENPL	2652	0.12	0.3	YES
21	MAD2L1	MAD2L1	MAD2L1	2928	0.11	0.3	YES
22	CENPN	CENPN	CENPN	2965	0.1	0.32	YES
23	SGOL2	SGOL2	SGOL2	3007	0.1	0.33	YES
24	CKAP5	CKAP5	CKAP5	3043	0.1	0.34	YES
25	MLF1IP	MLF1IP	MLF1IP	3110	0.1	0.36	YES
26	SMC3	SMC3	SMC3	3164	0.098	0.37	YES
27	CDC20	CDC20	CDC20	3237	0.096	0.38	YES
28	BIRC5	BIRC5	BIRC5	3259	0.096	0.39	YES
29	SPC24	SPC24	SPC24	3390	0.091	0.4	YES
30	PPP2R5D	PPP2R5D	PPP2R5D	3425	0.09	0.41	YES
31	BUB1	BUB1	BUB1	3429	0.09	0.42	YES
32	PLK1	PLK1	PLK1	3481	0.088	0.43	YES
33	MAD1L1	MAD1L1	MAD1L1	3555	0.086	0.44	YES
34	CENPC1	CENPC1	CENPC1	3616	0.085	0.45	YES
35	RAD21	RAD21	RAD21	3786	0.08	0.45	YES
36	CCDC99	CCDC99	CCDC99	3828	0.079	0.46	YES
37	SEC13	SEC13	SEC13	4125	0.072	0.46	YES
38	STAG1	STAG1	STAG1	4184	0.071	0.47	YES
39	KNTC1	KNTC1	KNTC1	4572	0.063	0.45	YES
40	BUB3	BUB3	BUB3	4610	0.062	0.46	YES
41	ZWILCH	ZWILCH	ZWILCH	4741	0.06	0.46	YES
42	ZWINT	ZWINT	ZWINT	4805	0.059	0.47	YES
43	AURKB	AURKB	AURKB	5304	0.05	0.45	NO
44	PAFAH1B1	PAFAH1B1	PAFAH1B1	5381	0.048	0.45	NO
45	SKA2	SKA2	SKA2	5467	0.047	0.46	NO
46	BUB1B	BUB1B	BUB1B	5954	0.039	0.43	NO
47	NUP107	NUP107	NUP107	6038	0.038	0.44	NO
48	AHCTF1	AHCTF1	AHCTF1	6213	0.035	0.43	NO
49	ITGB3BP	ITGB3BP	ITGB3BP	6223	0.035	0.44	NO
50	PPP1CC	PPP1CC	PPP1CC	6295	0.034	0.44	NO
51	STAG2	STAG2	STAG2	6410	0.032	0.44	NO
52	SEH1L	SEH1L	SEH1L	6483	0.031	0.44	NO
53	NUP37	NUP37	NUP37	6627	0.029	0.43	NO
54	RCC2	RCC2	RCC2	6638	0.028	0.44	NO
55	NUP43	NUP43	NUP43	6678	0.028	0.44	NO
56	CENPT	CENPT	CENPT	6748	0.027	0.44	NO
57	PPP2R5C	PPP2R5C	PPP2R5C	6918	0.025	0.43	NO
58	PMF1	PMF1	PMF1	7229	0.02	0.42	NO
59	DSN1	DSN1	DSN1	7371	0.018	0.42	NO
60	RANGAP1	RANGAP1	RANGAP1	7482	0.017	0.41	NO
61	NSL1	NSL1	NSL1	7591	0.016	0.41	NO
62	CENPH	CENPH	CENPH	7600	0.016	0.41	NO
63	PPP2CA	PPP2CA	PPP2CA	7776	0.014	0.4	NO
64	NUP85	NUP85	NUP85	7945	0.011	0.4	NO
65	XPO1	XPO1	XPO1	8090	0.0091	0.39	NO
66	NUDC	NUDC	NUDC	8273	0.0068	0.38	NO
67	MAPRE1	MAPRE1	MAPRE1	8357	0.0056	0.38	NO
68	PPP2R5E	PPP2R5E	PPP2R5E	8930	-0.0017	0.35	NO
69	NUP133	NUP133	NUP133	9516	-0.0092	0.32	NO
70	CLIP1	CLIP1	CLIP1	9924	-0.014	0.3	NO
71	NDEL1	NDEL1	NDEL1	10164	-0.017	0.29	NO
72	PPP2R1A	PPP2R1A	PPP2R1A	10379	-0.02	0.28	NO
73	CLASP1	CLASP1	CLASP1	10585	-0.023	0.27	NO
74	TAOK1	TAOK1	TAOK1	11044	-0.03	0.25	NO
75	PPP2R1B	PPP2R1B	PPP2R1B	11430	-0.036	0.23	NO
76	ZW10	ZW10	ZW10	12386	-0.053	0.19	NO
77	MIS12	MIS12	MIS12	12691	-0.059	0.18	NO
78	PPP2R5A	PPP2R5A	PPP2R5A	13062	-0.066	0.17	NO
79	KIF2A	KIF2A	KIF2A	13302	-0.072	0.17	NO
80	RANBP2	RANBP2	RANBP2	13540	-0.078	0.17	NO
81	CENPK	CENPK	CENPK	13704	-0.082	0.17	NO
82	PPP2CB	PPP2CB	PPP2CB	14713	-0.11	0.14	NO
83	B9D2	B9D2	B9D2	15050	-0.12	0.14	NO
84	CENPM	CENPM	CENPM	15068	-0.13	0.15	NO
85	RPS27	RPS27	RPS27	17443	-0.27	0.065	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	FBXO6	FBXO6	FBXO6	1980	0.15	0.022	YES
2	FBXO4	FBXO4	FBXO4	2321	0.13	0.12	YES
3	FKBP9	FKBP9	FKBP9	2379	0.13	0.23	YES
4	USP11	USP11	USP11	3652	0.084	0.23	YES
5	KIF13A	KIF13A	KIF13A	3813	0.079	0.29	YES
6	FBXW2	FBXW2	FBXW2	4178	0.071	0.33	YES
7	FBXW5	FBXW5	FBXW5	5269	0.05	0.32	YES
8	XRN2	XRN2	XRN2	5480	0.047	0.35	YES
9	FBXL3	FBXL3	FBXL3	5916	0.04	0.36	YES
10	TCP1	TCP1	TCP1	6224	0.035	0.37	YES
11	FBXW7	FBXW7	FBXW7	6314	0.034	0.4	YES
12	NOP56	NOP56	NOP56	6577	0.029	0.41	YES
13	KIFC3	KIFC3	KIFC3	6816	0.026	0.42	YES
14	CCT4	CCT4	CCT4	7656	0.015	0.38	NO
15	CCT5	CCT5	CCT5	7854	0.012	0.38	NO
16	CCT6A	CCT6A	CCT6A	8420	0.0048	0.36	NO
17	CCT2	CCT2	CCT2	8545	0.0032	0.36	NO
18	CCT8	CCT8	CCT8	8671	0.0014	0.35	NO
19	CCT7	CCT7	CCT7	9207	-0.0051	0.32	NO
20	CCT3	CCT3	CCT3	9334	-0.007	0.32	NO
21	FBXL5	FBXL5	FBXL5	9627	-0.011	0.32	NO
22	ARFGEF2	ARFGEF2	ARFGEF2	9747	-0.012	0.32	NO
23	LONP2	LONP2	LONP2	10116	-0.017	0.32	NO
24	FBXW4	FBXW4	FBXW4	10831	-0.026	0.3	NO
25	AP3M1	AP3M1	AP3M1	11628	-0.039	0.29	NO
26	SPHK1	SPHK1	SPHK1	14283	-0.098	0.23	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	HIST1H2BN	HIST1H2BN	HIST1H2BN	38	0.54	0.017	YES
2	SYCP1	SYCP1	SYCP1	130	0.44	0.028	YES
3	CDKN2C	CDKN2C	CDKN2C	154	0.43	0.042	YES
4	RPA4	RPA4	RPA4	413	0.33	0.04	YES
5	HIST1H2BB	HIST1H2BB	HIST1H2BB	430	0.33	0.051	YES
6	STAG3	STAG3	STAG3	491	0.31	0.059	YES
7	HIST1H2BC	HIST1H2BC	HIST1H2BC	589	0.29	0.064	YES
8	HIST1H2BE	HIST1H2BE	HIST1H2BE	592	0.29	0.075	YES
9	HIST1H2BO	HIST1H2BO	HIST1H2BO	610	0.29	0.084	YES
10	PRIM1	PRIM1	PRIM1	731	0.27	0.087	YES
11	CENPP	CENPP	CENPP	822	0.26	0.092	YES
12	HIST1H2BI	HIST1H2BI	HIST1H2BI	936	0.24	0.094	YES
13	SYCP3	SYCP3	SYCP3	1021	0.23	0.098	YES
14	SYCP2	SYCP2	SYCP2	1046	0.23	0.1	YES
15	HIST2H4A	HIST2H4A	HIST2H4A	1249	0.2	0.1	YES
16	CCNE2	CCNE2	CCNE2	1344	0.19	0.1	YES
17	HIST1H2BK	HIST1H2BK	HIST1H2BK	1353	0.19	0.11	YES
18	HIST1H4J	HIST1H4J	HIST1H4J	1453	0.18	0.11	YES
19	NDC80	NDC80	NDC80	1594	0.17	0.11	YES
20	CASC5	CASC5	CASC5	1596	0.17	0.12	YES
21	HIST1H2AD	HIST1H2AD	HIST1H2AD	1620	0.17	0.12	YES
22	CENPA	CENPA	CENPA	1671	0.17	0.12	YES
23	PPP2R3B	PPP2R3B	PPP2R3B	1714	0.16	0.13	YES
24	PPP2R5B	PPP2R5B	PPP2R5B	1760	0.16	0.13	YES
25	CENPO	CENPO	CENPO	1766	0.16	0.14	YES
26	SPC25	SPC25	SPC25	1778	0.16	0.14	YES
27	APITD1	APITD1	APITD1	1787	0.16	0.15	YES
28	HIST2H2BE	HIST2H2BE	HIST2H2BE	1794	0.16	0.15	YES
29	HIST1H2BJ	HIST1H2BJ	HIST1H2BJ	1800	0.16	0.16	YES
30	HIST2H2AA3	HIST2H2AA3	HIST2H2AA3	1826	0.16	0.16	YES
31	CDKN2A	CDKN2A	CDKN2A	1834	0.16	0.17	YES
32	CCNA2	CCNA2	CCNA2	1868	0.16	0.17	YES
33	SMC1A	SMC1A	SMC1A	1894	0.15	0.17	YES
34	KIF18A	KIF18A	KIF18A	1917	0.15	0.18	YES
35	SGOL1	SGOL1	SGOL1	1937	0.15	0.18	YES
36	FBXO5	FBXO5	FBXO5	1950	0.15	0.19	YES
37	ANAPC10	ANAPC10	ANAPC10	1952	0.15	0.19	YES
38	MCM8	MCM8	MCM8	2007	0.15	0.2	YES
39	CDKN1B	CDKN1B	CDKN1B	2068	0.14	0.2	YES
40	TYMS	TYMS	TYMS	2098	0.14	0.2	YES
41	DBF4	DBF4	DBF4	2115	0.14	0.2	YES
42	CENPI	CENPI	CENPI	2215	0.14	0.2	YES
43	ERCC6L	ERCC6L	ERCC6L	2253	0.14	0.21	YES
44	SKA1	SKA1	SKA1	2322	0.13	0.21	YES
45	CDC45	CDC45	CDC45	2381	0.13	0.21	YES
46	NEK2	NEK2	NEK2	2411	0.13	0.21	YES
47	KIF20A	KIF20A	KIF20A	2461	0.13	0.22	YES
48	KIF2C	KIF2C	KIF2C	2488	0.12	0.22	YES
49	CDCA8	CDCA8	CDCA8	2515	0.12	0.22	YES
50	CENPQ	CENPQ	CENPQ	2532	0.12	0.22	YES
51	KIF23	KIF23	KIF23	2543	0.12	0.23	YES
52	CDC26	CDC26	CDC26	2574	0.12	0.23	YES
53	INCENP	INCENP	INCENP	2608	0.12	0.23	YES
54	RBBP7	RBBP7	RBBP7	2637	0.12	0.24	YES
55	NUF2	NUF2	NUF2	2651	0.12	0.24	YES
56	CENPL	CENPL	CENPL	2652	0.12	0.24	YES
57	CDC25B	CDC25B	CDC25B	2737	0.11	0.24	YES
58	POLA1	POLA1	POLA1	2743	0.11	0.25	YES
59	GINS1	GINS1	GINS1	2779	0.11	0.25	YES
60	CCNB2	CCNB2	CCNB2	2786	0.11	0.25	YES
61	CDKN2D	CDKN2D	CDKN2D	2826	0.11	0.26	YES
62	HIST1H4I	HIST1H4I	HIST1H4I	2837	0.11	0.26	YES
63	CDKN2B	CDKN2B	CDKN2B	2868	0.11	0.26	YES
64	MAD2L1	MAD2L1	MAD2L1	2928	0.11	0.26	YES
65	HIST1H2AB	HIST1H2AB	HIST1H2AB	2940	0.11	0.26	YES
66	CENPN	CENPN	CENPN	2965	0.1	0.27	YES
67	SGOL2	SGOL2	SGOL2	3007	0.1	0.27	YES
68	CDK2	CDK2	CDK2	3020	0.1	0.27	YES
69	HIST2H2AC	HIST2H2AC	HIST2H2AC	3033	0.1	0.28	YES
70	CKAP5	CKAP5	CKAP5	3043	0.1	0.28	YES
71	LIN52	LIN52	LIN52	3087	0.1	0.28	YES
72	HIST1H4E	HIST1H4E	HIST1H4E	3091	0.1	0.28	YES
73	HIST1H2AE	HIST1H2AE	HIST1H2AE	3097	0.1	0.29	YES
74	MLF1IP	MLF1IP	MLF1IP	3110	0.1	0.29	YES
75	HIST4H4	HIST4H4	HIST4H4	3117	0.099	0.29	YES
76	SUN2	SUN2	SUN2	3121	0.099	0.3	YES
77	SMC3	SMC3	SMC3	3164	0.098	0.3	YES
78	CDC20	CDC20	CDC20	3237	0.096	0.3	YES
79	UBE2C	UBE2C	UBE2C	3242	0.096	0.3	YES
80	BIRC5	BIRC5	BIRC5	3259	0.096	0.3	YES
81	POLE	POLE	POLE	3269	0.095	0.3	YES
82	CEP76	CEP76	CEP76	3273	0.095	0.31	YES
83	CDC25C	CDC25C	CDC25C	3339	0.092	0.31	YES
84	ANAPC2	ANAPC2	ANAPC2	3369	0.092	0.31	YES
85	SPC24	SPC24	SPC24	3390	0.091	0.31	YES
86	CEP135	CEP135	CEP135	3403	0.091	0.31	YES
87	AURKA	AURKA	AURKA	3404	0.091	0.32	YES
88	PPP2R5D	PPP2R5D	PPP2R5D	3425	0.09	0.32	YES
89	BUB1	BUB1	BUB1	3429	0.09	0.32	YES
90	CDK5RAP2	CDK5RAP2	CDK5RAP2	3432	0.09	0.33	YES
91	OIP5	OIP5	OIP5	3444	0.09	0.33	YES
92	SMC1B	SMC1B	SMC1B	3472	0.088	0.33	YES
93	PLK1	PLK1	PLK1	3481	0.088	0.33	YES
94	PSMC3	PSMC3	PSMC3	3492	0.088	0.34	YES
95	CDC6	CDC6	CDC6	3547	0.086	0.34	YES
96	MAD1L1	MAD1L1	MAD1L1	3555	0.086	0.34	YES
97	PLK4	PLK4	PLK4	3567	0.086	0.34	YES
98	CENPC1	CENPC1	CENPC1	3616	0.085	0.34	YES
99	TUBGCP3	TUBGCP3	TUBGCP3	3633	0.084	0.34	YES
100	PSMC4	PSMC4	PSMC4	3677	0.083	0.34	YES
101	RAD1	RAD1	RAD1	3707	0.082	0.35	YES
102	LIN54	LIN54	LIN54	3767	0.08	0.34	YES
103	RAD21	RAD21	RAD21	3786	0.08	0.35	YES
104	PSMD8	PSMD8	PSMD8	3801	0.08	0.35	YES
105	CCDC99	CCDC99	CCDC99	3828	0.079	0.35	YES
106	SYNE1	SYNE1	SYNE1	3926	0.076	0.35	YES
107	E2F4	E2F4	E2F4	3967	0.076	0.35	YES
108	GINS2	GINS2	GINS2	3981	0.076	0.35	YES
109	SDCCAG8	SDCCAG8	SDCCAG8	4111	0.073	0.35	YES
110	SEC13	SEC13	SEC13	4125	0.072	0.35	YES
111	TP53	TP53	TP53	4180	0.071	0.35	YES
112	STAG1	STAG1	STAG1	4184	0.071	0.35	YES
113	NINL	NINL	NINL	4199	0.071	0.35	YES
114	DCTN3	DCTN3	DCTN3	4217	0.07	0.35	YES
115	TUBG2	TUBG2	TUBG2	4262	0.069	0.35	YES
116	RBL1	RBL1	RBL1	4295	0.069	0.35	YES
117	FEN1	FEN1	FEN1	4315	0.068	0.36	YES
118	HJURP	HJURP	HJURP	4400	0.066	0.35	YES
119	ALMS1	ALMS1	ALMS1	4432	0.066	0.35	YES
120	PRIM2	PRIM2	PRIM2	4446	0.066	0.36	YES
121	RRM2	RRM2	RRM2	4476	0.065	0.36	YES
122	E2F1	E2F1	E2F1	4500	0.064	0.36	YES
123	TUBGCP5	TUBGCP5	TUBGCP5	4524	0.064	0.36	YES
124	POLE2	POLE2	POLE2	4564	0.063	0.36	YES
125	KNTC1	KNTC1	KNTC1	4572	0.063	0.36	YES
126	PSMD3	PSMD3	PSMD3	4587	0.063	0.36	YES
127	CEP72	CEP72	CEP72	4597	0.062	0.36	YES
128	BUB3	BUB3	BUB3	4610	0.062	0.36	YES
129	LIN37	LIN37	LIN37	4622	0.062	0.37	YES
130	CEP192	CEP192	CEP192	4642	0.062	0.37	YES
131	PSMD13	PSMD13	PSMD13	4681	0.061	0.37	YES
132	MCM5	MCM5	MCM5	4718	0.06	0.37	YES
133	HIST1H4B	HIST1H4B	HIST1H4B	4727	0.06	0.37	YES
134	ZWILCH	ZWILCH	ZWILCH	4741	0.06	0.37	YES
135	LMNB1	LMNB1	LMNB1	4766	0.06	0.37	YES
136	TERF2IP	TERF2IP	TERF2IP	4786	0.059	0.37	YES
137	RPA3	RPA3	RPA3	4798	0.059	0.38	YES
138	PSMD7	PSMD7	PSMD7	4800	0.059	0.38	YES
139	ZWINT	ZWINT	ZWINT	4805	0.059	0.38	YES
140	HUS1	HUS1	HUS1	4861	0.058	0.38	YES
141	NEDD1	NEDD1	NEDD1	4884	0.057	0.38	YES
142	TEX12	TEX12	TEX12	4920	0.056	0.38	YES
143	TFDP1	TFDP1	TFDP1	4949	0.056	0.38	YES
144	SKP2	SKP2	SKP2	4985	0.055	0.38	YES
145	RFC2	RFC2	RFC2	5038	0.054	0.38	YES
146	PSMB7	PSMB7	PSMB7	5067	0.054	0.38	YES
147	MCM6	MCM6	MCM6	5102	0.053	0.38	YES
148	HIST1H4H	HIST1H4H	HIST1H4H	5130	0.053	0.38	YES
149	RFC4	RFC4	RFC4	5137	0.053	0.38	YES
150	GMNN	GMNN	GMNN	5246	0.051	0.38	YES
151	CDT1	CDT1	CDT1	5272	0.05	0.38	YES
152	PTTG1	PTTG1	PTTG1	5285	0.05	0.38	YES
153	PSMB1	PSMB1	PSMB1	5290	0.05	0.38	YES
154	OFD1	OFD1	OFD1	5300	0.05	0.38	YES
155	AURKB	AURKB	AURKB	5304	0.05	0.38	YES
156	PAFAH1B1	PAFAH1B1	PAFAH1B1	5381	0.048	0.38	NO
157	LIN9	LIN9	LIN9	5412	0.048	0.38	NO
158	CSNK1E	CSNK1E	CSNK1E	5461	0.047	0.38	NO
159	SKA2	SKA2	SKA2	5467	0.047	0.38	NO
160	CDK4	CDK4	CDK4	5495	0.046	0.38	NO
161	CEP250	CEP250	CEP250	5588	0.045	0.38	NO
162	H2AFZ	H2AFZ	H2AFZ	5623	0.044	0.38	NO
163	TUBGCP2	TUBGCP2	TUBGCP2	5659	0.044	0.38	NO
164	MYBL2	MYBL2	MYBL2	5662	0.044	0.38	NO
165	PCNA	PCNA	PCNA	5678	0.044	0.38	NO
166	CDC25A	CDC25A	CDC25A	5702	0.043	0.38	NO
167	CEP63	CEP63	CEP63	5717	0.043	0.38	NO
168	CDC27	CDC27	CDC27	5718	0.043	0.38	NO
169	TINF2	TINF2	TINF2	5815	0.042	0.38	NO
170	RAD9A	RAD9A	RAD9A	5860	0.041	0.38	NO
171	SMARCA5	SMARCA5	SMARCA5	5880	0.041	0.38	NO
172	PCNT	PCNT	PCNT	5941	0.04	0.38	NO
173	BUB1B	BUB1B	BUB1B	5954	0.039	0.38	NO
174	PSMA7	PSMA7	PSMA7	6019	0.038	0.38	NO
175	POLA2	POLA2	POLA2	6032	0.038	0.38	NO
176	NUP107	NUP107	NUP107	6038	0.038	0.38	NO
177	SSNA1	SSNA1	SSNA1	6086	0.037	0.38	NO
178	POLD1	POLD1	POLD1	6121	0.037	0.38	NO
179	ACD	ACD	ACD	6159	0.036	0.37	NO
180	AHCTF1	AHCTF1	AHCTF1	6213	0.035	0.37	NO
181	ITGB3BP	ITGB3BP	ITGB3BP	6223	0.035	0.37	NO
182	MCM10	MCM10	MCM10	6249	0.035	0.37	NO
183	PPP1CC	PPP1CC	PPP1CC	6295	0.034	0.37	NO
184	TK2	TK2	TK2	6308	0.034	0.37	NO
185	MCM2	MCM2	MCM2	6309	0.034	0.37	NO
186	RPA2	RPA2	RPA2	6388	0.032	0.37	NO
187	RPA1	RPA1	RPA1	6399	0.032	0.37	NO
188	STAG2	STAG2	STAG2	6410	0.032	0.37	NO
189	LMNA	LMNA	LMNA	6416	0.032	0.37	NO
190	PSMD6	PSMD6	PSMD6	6423	0.032	0.37	NO
191	CEP70	CEP70	CEP70	6456	0.031	0.37	NO
192	SEH1L	SEH1L	SEH1L	6483	0.031	0.37	NO
193	NUP37	NUP37	NUP37	6627	0.029	0.36	NO
194	DYRK1A	DYRK1A	DYRK1A	6635	0.028	0.37	NO
195	RCC2	RCC2	RCC2	6638	0.028	0.37	NO
196	NUP43	NUP43	NUP43	6678	0.028	0.37	NO
197	PSMC2	PSMC2	PSMC2	6713	0.027	0.36	NO
198	HIST1H2BG	HIST1H2BG	HIST1H2BG	6722	0.027	0.36	NO
199	CENPT	CENPT	CENPT	6748	0.027	0.36	NO
200	PSMF1	PSMF1	PSMF1	6801	0.026	0.36	NO
201	DYNC1H1	DYNC1H1	DYNC1H1	6803	0.026	0.36	NO
202	ANAPC7	ANAPC7	ANAPC7	6847	0.026	0.36	NO
203	CEP290	CEP290	CEP290	6907	0.025	0.36	NO
204	ATR	ATR	ATR	6912	0.025	0.36	NO
205	CDC16	CDC16	CDC16	6913	0.025	0.36	NO
206	PPP2R5C	PPP2R5C	PPP2R5C	6918	0.025	0.36	NO
207	RFC5	RFC5	RFC5	6994	0.024	0.36	NO
208	ACTR1A	ACTR1A	ACTR1A	7021	0.023	0.36	NO
209	PSMD10	PSMD10	PSMD10	7024	0.023	0.36	NO
210	PSMA2	PSMA2	PSMA2	7057	0.023	0.36	NO
211	RSF1	RSF1	RSF1	7064	0.023	0.36	NO
212	TUBG1	TUBG1	TUBG1	7135	0.022	0.36	NO
213	DCTN2	DCTN2	DCTN2	7148	0.022	0.36	NO
214	MDM2	MDM2	MDM2	7163	0.021	0.36	NO
215	CDC23	CDC23	CDC23	7177	0.021	0.36	NO
216	PSMB6	PSMB6	PSMB6	7210	0.021	0.36	NO
217	PMF1	PMF1	PMF1	7229	0.02	0.36	NO
218	PRKACA	PRKACA	PRKACA	7253	0.02	0.35	NO
219	PSMD2	PSMD2	PSMD2	7266	0.02	0.35	NO
220	PSMD11	PSMD11	PSMD11	7279	0.02	0.35	NO
221	TUBB	TUBB	TUBB	7285	0.02	0.36	NO
222	MCM7	MCM7	MCM7	7296	0.02	0.36	NO
223	MCM3	MCM3	MCM3	7306	0.02	0.36	NO
224	DCTN1	DCTN1	DCTN1	7341	0.019	0.35	NO
225	ANAPC4	ANAPC4	ANAPC4	7350	0.019	0.35	NO
226	CCNB1	CCNB1	CCNB1	7358	0.019	0.36	NO
227	DSN1	DSN1	DSN1	7371	0.018	0.36	NO
228	NUMA1	NUMA1	NUMA1	7414	0.018	0.35	NO
229	PSMA1	PSMA1	PSMA1	7436	0.018	0.35	NO
230	FGFR1OP	FGFR1OP	FGFR1OP	7452	0.018	0.35	NO
231	RANGAP1	RANGAP1	RANGAP1	7482	0.017	0.35	NO
232	DHFR	DHFR	DHFR	7489	0.017	0.35	NO
233	CDC7	CDC7	CDC7	7568	0.016	0.35	NO
234	NSL1	NSL1	NSL1	7591	0.016	0.35	NO
235	CENPH	CENPH	CENPH	7600	0.016	0.35	NO
236	DYNLL1	DYNLL1	DYNLL1	7642	0.015	0.35	NO
237	PSMD1	PSMD1	PSMD1	7682	0.015	0.34	NO
238	PPP2CA	PPP2CA	PPP2CA	7776	0.014	0.34	NO
239	CDK1	CDK1	CDK1	7814	0.013	0.34	NO
240	POT1	POT1	POT1	7890	0.012	0.33	NO
241	NUP85	NUP85	NUP85	7945	0.011	0.33	NO
242	PSMA4	PSMA4	PSMA4	7957	0.011	0.33	NO
243	HAUS2	HAUS2	HAUS2	7987	0.011	0.33	NO
244	E2F3	E2F3	E2F3	7994	0.011	0.33	NO
245	PSMD14	PSMD14	PSMD14	8020	0.01	0.33	NO
246	RFWD2	RFWD2	RFWD2	8040	0.0098	0.33	NO
247	XPO1	XPO1	XPO1	8090	0.0091	0.33	NO
248	POLD3	POLD3	POLD3	8115	0.0089	0.32	NO
249	ATRIP	ATRIP	ATRIP	8149	0.0083	0.32	NO
250	BRCA1	BRCA1	BRCA1	8211	0.0075	0.32	NO
251	NUDC	NUDC	NUDC	8273	0.0068	0.32	NO
252	YWHAE	YWHAE	YWHAE	8286	0.0066	0.32	NO
253	YWHAG	YWHAG	YWHAG	8316	0.0062	0.32	NO
254	PSMC1	PSMC1	PSMC1	8323	0.006	0.32	NO
255	MAPRE1	MAPRE1	MAPRE1	8357	0.0056	0.31	NO
256	UBE2E1	UBE2E1	UBE2E1	8497	0.0038	0.31	NO
257	ANAPC5	ANAPC5	ANAPC5	8513	0.0036	0.31	NO
258	PSMB9	PSMB9	PSMB9	8528	0.0034	0.3	NO
259	TUBA1A	TUBA1A	TUBA1A	8550	0.0031	0.3	NO
260	CKS1B	CKS1B	CKS1B	8565	0.0028	0.3	NO
261	RBBP4	RBBP4	RBBP4	8637	0.002	0.3	NO
262	CEP164	CEP164	CEP164	8641	0.0019	0.3	NO
263	TERF2	TERF2	TERF2	8701	0.001	0.3	NO
264	CENPJ	CENPJ	CENPJ	8712	0.00085	0.3	NO
265	H2AFX	H2AFX	H2AFX	8807	-0.00012	0.29	NO
266	BTRC	BTRC	BTRC	8845	-0.0006	0.29	NO
267	PPP2R5E	PPP2R5E	PPP2R5E	8930	-0.0017	0.28	NO
268	CUL1	CUL1	CUL1	8953	-0.0019	0.28	NO
269	PSMA3	PSMA3	PSMA3	8981	-0.0023	0.28	NO
270	HSP90AA1	HSP90AA1	HSP90AA1	8987	-0.0023	0.28	NO
271	CCNE1	CCNE1	CCNE1	9036	-0.003	0.28	NO
272	PSMB2	PSMB2	PSMB2	9105	-0.0038	0.28	NO
273	POLD2	POLD2	POLD2	9239	-0.0056	0.27	NO
274	NHP2	NHP2	NHP2	9243	-0.0056	0.27	NO
275	RBL2	RBL2	RBL2	9268	-0.0061	0.27	NO
276	PSMD9	PSMD9	PSMD9	9296	-0.0065	0.27	NO
277	CCNH	CCNH	CCNH	9339	-0.007	0.26	NO
278	UBE2I	UBE2I	UBE2I	9447	-0.0085	0.26	NO
279	LIG1	LIG1	LIG1	9499	-0.009	0.26	NO
280	NUP133	NUP133	NUP133	9516	-0.0092	0.26	NO
281	MCM4	MCM4	MCM4	9529	-0.0093	0.26	NO
282	PSMC6	PSMC6	PSMC6	9566	-0.0099	0.25	NO
283	DIDO1	DIDO1	DIDO1	9573	-0.01	0.25	NO
284	CHEK2	CHEK2	CHEK2	9591	-0.01	0.25	NO
285	RUVBL1	RUVBL1	RUVBL1	9594	-0.01	0.25	NO
286	PSMB4	PSMB4	PSMB4	9664	-0.011	0.25	NO
287	RUVBL2	RUVBL2	RUVBL2	9749	-0.012	0.25	NO
288	CCND3	CCND3	CCND3	9829	-0.013	0.24	NO
289	PSMC5	PSMC5	PSMC5	9854	-0.013	0.24	NO
290	HIST1H2BF	HIST1H2BF	HIST1H2BF	9908	-0.014	0.24	NO
291	NPM1	NPM1	NPM1	9916	-0.014	0.24	NO
292	CLIP1	CLIP1	CLIP1	9924	-0.014	0.24	NO
293	SKP1	SKP1	SKP1	9965	-0.015	0.24	NO
294	HSPA2	HSPA2	HSPA2	10062	-0.016	0.23	NO
295	NDEL1	NDEL1	NDEL1	10164	-0.017	0.23	NO
296	UBA52	UBA52	UBA52	10204	-0.018	0.23	NO
297	E2F2	E2F2	E2F2	10206	-0.018	0.23	NO
298	AZI1	AZI1	AZI1	10243	-0.018	0.22	NO
299	GORASP1	GORASP1	GORASP1	10321	-0.019	0.22	NO
300	PPP2R1A	PPP2R1A	PPP2R1A	10379	-0.02	0.22	NO
301	HIST1H2BL	HIST1H2BL	HIST1H2BL	10427	-0.021	0.22	NO
302	PSMB5	PSMB5	PSMB5	10454	-0.021	0.22	NO
303	MNAT1	MNAT1	MNAT1	10490	-0.022	0.22	NO
304	HIST1H4C	HIST1H4C	HIST1H4C	10522	-0.022	0.22	NO
305	CLASP1	CLASP1	CLASP1	10585	-0.023	0.21	NO
306	DKC1	DKC1	DKC1	10597	-0.023	0.21	NO
307	MAX	MAX	MAX	10617	-0.023	0.21	NO
308	HIST1H2AJ	HIST1H2AJ	HIST1H2AJ	10711	-0.025	0.21	NO
309	PSMA6	PSMA6	PSMA6	10746	-0.025	0.21	NO
310	PSMB3	PSMB3	PSMB3	10811	-0.026	0.2	NO
311	HIST1H4K	HIST1H4K	HIST1H4K	10926	-0.028	0.2	NO
312	PSME2	PSME2	PSME2	10986	-0.029	0.2	NO
313	SYNE2	SYNE2	SYNE2	11040	-0.03	0.2	NO
314	TAOK1	TAOK1	TAOK1	11044	-0.03	0.2	NO
315	HIST1H4L	HIST1H4L	HIST1H4L	11080	-0.03	0.2	NO
316	AKAP9	AKAP9	AKAP9	11235	-0.032	0.19	NO
317	DYNC1I2	DYNC1I2	DYNC1I2	11303	-0.033	0.19	NO
318	PSME4	PSME4	PSME4	11425	-0.035	0.18	NO
319	PPP2R1B	PPP2R1B	PPP2R1B	11430	-0.036	0.18	NO
320	PSMD4	PSMD4	PSMD4	11490	-0.037	0.18	NO
321	PSMB8	PSMB8	PSMB8	11591	-0.039	0.18	NO
322	GINS4	GINS4	GINS4	11609	-0.039	0.18	NO
323	CETN2	CETN2	CETN2	11942	-0.044	0.16	NO
324	UBE2D1	UBE2D1	UBE2D1	11957	-0.045	0.16	NO
325	ANAPC11	ANAPC11	ANAPC11	11983	-0.045	0.16	NO
326	ANAPC1	ANAPC1	ANAPC1	11987	-0.045	0.16	NO
327	PCM1	PCM1	PCM1	12020	-0.046	0.16	NO
328	PSMD12	PSMD12	PSMD12	12043	-0.046	0.16	NO
329	HDAC1	HDAC1	HDAC1	12114	-0.048	0.16	NO
330	TUBGCP6	TUBGCP6	TUBGCP6	12297	-0.051	0.15	NO
331	DNA2	DNA2	DNA2	12364	-0.052	0.15	NO
332	ZW10	ZW10	ZW10	12386	-0.053	0.15	NO
333	WEE1	WEE1	WEE1	12424	-0.053	0.15	NO
334	HIST1H2AC	HIST1H2AC	HIST1H2AC	12559	-0.056	0.15	NO
335	PSMA5	PSMA5	PSMA5	12579	-0.057	0.15	NO
336	CSNK1D	CSNK1D	CSNK1D	12595	-0.057	0.15	NO
337	TUBA4A	TUBA4A	TUBA4A	12633	-0.057	0.15	NO
338	HIST1H2BD	HIST1H2BD	HIST1H2BD	12668	-0.058	0.15	NO
339	MIS12	MIS12	MIS12	12691	-0.059	0.15	NO
340	RAD17	RAD17	RAD17	12814	-0.062	0.14	NO
341	HIST1H4A	HIST1H4A	HIST1H4A	12831	-0.062	0.15	NO
342	HIST3H2BB	HIST3H2BB	HIST3H2BB	12875	-0.063	0.15	NO
343	RFC3	RFC3	RFC3	12945	-0.064	0.14	NO
344	PPP2R5A	PPP2R5A	PPP2R5A	13062	-0.066	0.14	NO
345	CDK6	CDK6	CDK6	13149	-0.068	0.14	NO
346	WRAP53	WRAP53	WRAP53	13252	-0.07	0.14	NO
347	KIF2A	KIF2A	KIF2A	13302	-0.072	0.14	NO
348	HIST1H2BH	HIST1H2BH	HIST1H2BH	13314	-0.072	0.14	NO
349	CEP57	CEP57	CEP57	13446	-0.075	0.13	NO
350	RANBP2	RANBP2	RANBP2	13540	-0.078	0.13	NO
351	PKMYT1	PKMYT1	PKMYT1	13586	-0.079	0.13	NO
352	RPS27A	RPS27A	RPS27A	13660	-0.081	0.13	NO
353	CENPK	CENPK	CENPK	13704	-0.082	0.13	NO
354	PPP2R2A	PPP2R2A	PPP2R2A	13749	-0.083	0.13	NO
355	TERF1	TERF1	TERF1	13791	-0.085	0.13	NO
356	PSME1	PSME1	PSME1	14099	-0.093	0.12	NO
357	TERT	TERT	TERT	14102	-0.093	0.12	NO
358	POLD4	POLD4	POLD4	14192	-0.096	0.12	NO
359	PSMD5	PSMD5	PSMD5	14232	-0.097	0.12	NO
360	CCNA1	CCNA1	CCNA1	14312	-0.099	0.12	NO
361	PRKAR2B	PRKAR2B	PRKAR2B	14367	-0.1	0.12	NO
362	CHEK1	CHEK1	CHEK1	14381	-0.1	0.12	NO
363	CCND1	CCND1	CCND1	14514	-0.11	0.12	NO
364	FKBP6	FKBP6	FKBP6	14545	-0.11	0.12	NO
365	PPP2CB	PPP2CB	PPP2CB	14713	-0.11	0.12	NO
366	B9D2	B9D2	B9D2	15050	-0.12	0.1	NO
367	CENPM	CENPM	CENPM	15068	-0.13	0.11	NO
368	HIST1H2BM	HIST1H2BM	HIST1H2BM	15272	-0.14	0.1	NO
369	ATM	ATM	ATM	15287	-0.14	0.1	NO
370	MYC	MYC	MYC	15517	-0.15	0.098	NO
371	CDKN1A	CDKN1A	CDKN1A	15730	-0.16	0.092	NO
372	CDK7	CDK7	CDK7	15848	-0.16	0.091	NO
373	RB1	RB1	RB1	15924	-0.16	0.093	NO
374	PSMB10	PSMB10	PSMB10	16018	-0.17	0.094	NO
375	CCND2	CCND2	CCND2	16505	-0.2	0.074	NO
376	E2F5	E2F5	E2F5	16623	-0.2	0.075	NO
377	CDC14A	CDC14A	CDC14A	16627	-0.2	0.082	NO
378	REC8	REC8	REC8	17021	-0.23	0.069	NO
379	RPS27	RPS27	RPS27	17443	-0.27	0.056	NO
380	HIST1H4D	HIST1H4D	HIST1H4D	17506	-0.28	0.062	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	RPA4	RPA4	RPA4	413	0.33	0.0079	YES
2	PRIM1	PRIM1	PRIM1	731	0.27	0.015	YES
3	CENPP	CENPP	CENPP	822	0.26	0.034	YES
4	NDC80	NDC80	NDC80	1594	0.17	0.008	YES
5	CASC5	CASC5	CASC5	1596	0.17	0.024	YES
6	CENPA	CENPA	CENPA	1671	0.17	0.035	YES
7	PPP2R5B	PPP2R5B	PPP2R5B	1760	0.16	0.045	YES
8	CENPO	CENPO	CENPO	1766	0.16	0.06	YES
9	SPC25	SPC25	SPC25	1778	0.16	0.074	YES
10	APITD1	APITD1	APITD1	1787	0.16	0.088	YES
11	SMC1A	SMC1A	SMC1A	1894	0.15	0.096	YES
12	KIF18A	KIF18A	KIF18A	1917	0.15	0.11	YES
13	SGOL1	SGOL1	SGOL1	1937	0.15	0.12	YES
14	FBXO5	FBXO5	FBXO5	1950	0.15	0.14	YES
15	MCM8	MCM8	MCM8	2007	0.15	0.14	YES
16	DBF4	DBF4	DBF4	2115	0.14	0.15	YES
17	CENPI	CENPI	CENPI	2215	0.14	0.16	YES
18	ERCC6L	ERCC6L	ERCC6L	2253	0.14	0.17	YES
19	SKA1	SKA1	SKA1	2322	0.13	0.18	YES
20	CDC45	CDC45	CDC45	2381	0.13	0.19	YES
21	KIF20A	KIF20A	KIF20A	2461	0.13	0.19	YES
22	KIF2C	KIF2C	KIF2C	2488	0.12	0.2	YES
23	CDCA8	CDCA8	CDCA8	2515	0.12	0.21	YES
24	CENPQ	CENPQ	CENPQ	2532	0.12	0.22	YES
25	KIF23	KIF23	KIF23	2543	0.12	0.24	YES
26	INCENP	INCENP	INCENP	2608	0.12	0.24	YES
27	NUF2	NUF2	NUF2	2651	0.12	0.25	YES
28	CENPL	CENPL	CENPL	2652	0.12	0.26	YES
29	POLA1	POLA1	POLA1	2743	0.11	0.27	YES
30	MAD2L1	MAD2L1	MAD2L1	2928	0.11	0.27	YES
31	CENPN	CENPN	CENPN	2965	0.1	0.28	YES
32	SGOL2	SGOL2	SGOL2	3007	0.1	0.28	YES
33	CDK2	CDK2	CDK2	3020	0.1	0.29	YES
34	CKAP5	CKAP5	CKAP5	3043	0.1	0.3	YES
35	MLF1IP	MLF1IP	MLF1IP	3110	0.1	0.3	YES
36	SMC3	SMC3	SMC3	3164	0.098	0.31	YES
37	CDC20	CDC20	CDC20	3237	0.096	0.32	YES
38	BIRC5	BIRC5	BIRC5	3259	0.096	0.32	YES
39	POLE	POLE	POLE	3269	0.095	0.33	YES
40	SPC24	SPC24	SPC24	3390	0.091	0.33	YES
41	PPP2R5D	PPP2R5D	PPP2R5D	3425	0.09	0.34	YES
42	BUB1	BUB1	BUB1	3429	0.09	0.35	YES
43	PLK1	PLK1	PLK1	3481	0.088	0.35	YES
44	PSMC3	PSMC3	PSMC3	3492	0.088	0.36	YES
45	CDC6	CDC6	CDC6	3547	0.086	0.36	YES
46	MAD1L1	MAD1L1	MAD1L1	3555	0.086	0.37	YES
47	CENPC1	CENPC1	CENPC1	3616	0.085	0.38	YES
48	PSMC4	PSMC4	PSMC4	3677	0.083	0.38	YES
49	RAD21	RAD21	RAD21	3786	0.08	0.38	YES
50	PSMD8	PSMD8	PSMD8	3801	0.08	0.39	YES
51	CCDC99	CCDC99	CCDC99	3828	0.079	0.4	YES
52	SEC13	SEC13	SEC13	4125	0.072	0.39	YES
53	STAG1	STAG1	STAG1	4184	0.071	0.39	YES
54	PRIM2	PRIM2	PRIM2	4446	0.066	0.38	YES
55	E2F1	E2F1	E2F1	4500	0.064	0.38	YES
56	POLE2	POLE2	POLE2	4564	0.063	0.39	YES
57	KNTC1	KNTC1	KNTC1	4572	0.063	0.39	YES
58	PSMD3	PSMD3	PSMD3	4587	0.063	0.4	YES
59	BUB3	BUB3	BUB3	4610	0.062	0.4	YES
60	PSMD13	PSMD13	PSMD13	4681	0.061	0.4	YES
61	MCM5	MCM5	MCM5	4718	0.06	0.41	YES
62	ZWILCH	ZWILCH	ZWILCH	4741	0.06	0.41	YES
63	RPA3	RPA3	RPA3	4798	0.059	0.41	YES
64	PSMD7	PSMD7	PSMD7	4800	0.059	0.42	YES
65	ZWINT	ZWINT	ZWINT	4805	0.059	0.42	YES
66	PSMB7	PSMB7	PSMB7	5067	0.054	0.41	YES
67	MCM6	MCM6	MCM6	5102	0.053	0.42	YES
68	GMNN	GMNN	GMNN	5246	0.051	0.41	YES
69	CDT1	CDT1	CDT1	5272	0.05	0.42	YES
70	PSMB1	PSMB1	PSMB1	5290	0.05	0.42	YES
71	AURKB	AURKB	AURKB	5304	0.05	0.42	YES
72	PAFAH1B1	PAFAH1B1	PAFAH1B1	5381	0.048	0.42	YES
73	SKA2	SKA2	SKA2	5467	0.047	0.42	NO
74	BUB1B	BUB1B	BUB1B	5954	0.039	0.4	NO
75	PSMA7	PSMA7	PSMA7	6019	0.038	0.4	NO
76	POLA2	POLA2	POLA2	6032	0.038	0.4	NO
77	NUP107	NUP107	NUP107	6038	0.038	0.41	NO
78	AHCTF1	AHCTF1	AHCTF1	6213	0.035	0.4	NO
79	ITGB3BP	ITGB3BP	ITGB3BP	6223	0.035	0.4	NO
80	MCM10	MCM10	MCM10	6249	0.035	0.41	NO
81	PPP1CC	PPP1CC	PPP1CC	6295	0.034	0.41	NO
82	MCM2	MCM2	MCM2	6309	0.034	0.41	NO
83	RPA2	RPA2	RPA2	6388	0.032	0.41	NO
84	RPA1	RPA1	RPA1	6399	0.032	0.41	NO
85	STAG2	STAG2	STAG2	6410	0.032	0.41	NO
86	PSMD6	PSMD6	PSMD6	6423	0.032	0.42	NO
87	SEH1L	SEH1L	SEH1L	6483	0.031	0.42	NO
88	NUP37	NUP37	NUP37	6627	0.029	0.41	NO
89	RCC2	RCC2	RCC2	6638	0.028	0.41	NO
90	NUP43	NUP43	NUP43	6678	0.028	0.41	NO
91	PSMC2	PSMC2	PSMC2	6713	0.027	0.41	NO
92	CENPT	CENPT	CENPT	6748	0.027	0.41	NO
93	PSMF1	PSMF1	PSMF1	6801	0.026	0.41	NO
94	PPP2R5C	PPP2R5C	PPP2R5C	6918	0.025	0.41	NO
95	PSMD10	PSMD10	PSMD10	7024	0.023	0.41	NO
96	PSMA2	PSMA2	PSMA2	7057	0.023	0.41	NO
97	PSMB6	PSMB6	PSMB6	7210	0.021	0.4	NO
98	PMF1	PMF1	PMF1	7229	0.02	0.4	NO
99	PSMD2	PSMD2	PSMD2	7266	0.02	0.4	NO
100	PSMD11	PSMD11	PSMD11	7279	0.02	0.4	NO
101	MCM7	MCM7	MCM7	7296	0.02	0.4	NO
102	MCM3	MCM3	MCM3	7306	0.02	0.4	NO
103	DSN1	DSN1	DSN1	7371	0.018	0.4	NO
104	PSMA1	PSMA1	PSMA1	7436	0.018	0.4	NO
105	RANGAP1	RANGAP1	RANGAP1	7482	0.017	0.4	NO
106	CDC7	CDC7	CDC7	7568	0.016	0.4	NO
107	NSL1	NSL1	NSL1	7591	0.016	0.4	NO
108	CENPH	CENPH	CENPH	7600	0.016	0.4	NO
109	PSMD1	PSMD1	PSMD1	7682	0.015	0.39	NO
110	PPP2CA	PPP2CA	PPP2CA	7776	0.014	0.39	NO
111	NUP85	NUP85	NUP85	7945	0.011	0.38	NO
112	PSMA4	PSMA4	PSMA4	7957	0.011	0.38	NO
113	E2F3	E2F3	E2F3	7994	0.011	0.38	NO
114	PSMD14	PSMD14	PSMD14	8020	0.01	0.38	NO
115	XPO1	XPO1	XPO1	8090	0.0091	0.38	NO
116	NUDC	NUDC	NUDC	8273	0.0068	0.37	NO
117	PSMC1	PSMC1	PSMC1	8323	0.006	0.37	NO
118	MAPRE1	MAPRE1	MAPRE1	8357	0.0056	0.37	NO
119	PSMB9	PSMB9	PSMB9	8528	0.0034	0.36	NO
120	PPP2R5E	PPP2R5E	PPP2R5E	8930	-0.0017	0.34	NO
121	PSMA3	PSMA3	PSMA3	8981	-0.0023	0.33	NO
122	PSMB2	PSMB2	PSMB2	9105	-0.0038	0.33	NO
123	PSMD9	PSMD9	PSMD9	9296	-0.0065	0.32	NO
124	NUP133	NUP133	NUP133	9516	-0.0092	0.31	NO
125	MCM4	MCM4	MCM4	9529	-0.0093	0.31	NO
126	PSMC6	PSMC6	PSMC6	9566	-0.0099	0.3	NO
127	PSMB4	PSMB4	PSMB4	9664	-0.011	0.3	NO
128	PSMC5	PSMC5	PSMC5	9854	-0.013	0.29	NO
129	CLIP1	CLIP1	CLIP1	9924	-0.014	0.29	NO
130	NDEL1	NDEL1	NDEL1	10164	-0.017	0.28	NO
131	UBA52	UBA52	UBA52	10204	-0.018	0.28	NO
132	E2F2	E2F2	E2F2	10206	-0.018	0.28	NO
133	GORASP1	GORASP1	GORASP1	10321	-0.019	0.28	NO
134	PPP2R1A	PPP2R1A	PPP2R1A	10379	-0.02	0.27	NO
135	PSMB5	PSMB5	PSMB5	10454	-0.021	0.27	NO
136	CLASP1	CLASP1	CLASP1	10585	-0.023	0.27	NO
137	PSMA6	PSMA6	PSMA6	10746	-0.025	0.26	NO
138	PSMB3	PSMB3	PSMB3	10811	-0.026	0.26	NO
139	PSME2	PSME2	PSME2	10986	-0.029	0.25	NO
140	TAOK1	TAOK1	TAOK1	11044	-0.03	0.25	NO
141	PSME4	PSME4	PSME4	11425	-0.035	0.24	NO
142	PPP2R1B	PPP2R1B	PPP2R1B	11430	-0.036	0.24	NO
143	PSMD4	PSMD4	PSMD4	11490	-0.037	0.24	NO
144	PSMB8	PSMB8	PSMB8	11591	-0.039	0.24	NO
145	PSMD12	PSMD12	PSMD12	12043	-0.046	0.22	NO
146	ZW10	ZW10	ZW10	12386	-0.053	0.2	NO
147	PSMA5	PSMA5	PSMA5	12579	-0.057	0.2	NO
148	MIS12	MIS12	MIS12	12691	-0.059	0.2	NO
149	PPP2R5A	PPP2R5A	PPP2R5A	13062	-0.066	0.18	NO
150	KIF2A	KIF2A	KIF2A	13302	-0.072	0.18	NO
151	RANBP2	RANBP2	RANBP2	13540	-0.078	0.17	NO
152	RPS27A	RPS27A	RPS27A	13660	-0.081	0.17	NO
153	CENPK	CENPK	CENPK	13704	-0.082	0.18	NO
154	PSME1	PSME1	PSME1	14099	-0.093	0.16	NO
155	PSMD5	PSMD5	PSMD5	14232	-0.097	0.16	NO
156	PPP2CB	PPP2CB	PPP2CB	14713	-0.11	0.15	NO
157	B9D2	B9D2	B9D2	15050	-0.12	0.14	NO
158	CENPM	CENPM	CENPM	15068	-0.13	0.15	NO
159	PSMB10	PSMB10	PSMB10	16018	-0.17	0.12	NO
160	RPS27	RPS27	RPS27	17443	-0.27	0.065	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	CDKN2C	CDKN2C	CDKN2C	154	0.43	0.014	YES
2	RPA4	RPA4	RPA4	413	0.33	0.017	YES
3	PRIM1	PRIM1	PRIM1	731	0.27	0.013	YES
4	CENPP	CENPP	CENPP	822	0.26	0.021	YES
5	CCNE2	CCNE2	CCNE2	1344	0.19	0.0029	YES
6	NDC80	NDC80	NDC80	1594	0.17	-0.0018	YES
7	CASC5	CASC5	CASC5	1596	0.17	0.007	YES
8	CENPA	CENPA	CENPA	1671	0.17	0.012	YES
9	PPP2R3B	PPP2R3B	PPP2R3B	1714	0.16	0.018	YES
10	PPP2R5B	PPP2R5B	PPP2R5B	1760	0.16	0.024	YES
11	CENPO	CENPO	CENPO	1766	0.16	0.032	YES
12	SPC25	SPC25	SPC25	1778	0.16	0.039	YES
13	APITD1	APITD1	APITD1	1787	0.16	0.047	YES
14	CDKN2A	CDKN2A	CDKN2A	1834	0.16	0.053	YES
15	CCNA2	CCNA2	CCNA2	1868	0.16	0.059	YES
16	SMC1A	SMC1A	SMC1A	1894	0.15	0.065	YES
17	KIF18A	KIF18A	KIF18A	1917	0.15	0.072	YES
18	SGOL1	SGOL1	SGOL1	1937	0.15	0.079	YES
19	FBXO5	FBXO5	FBXO5	1950	0.15	0.086	YES
20	ANAPC10	ANAPC10	ANAPC10	1952	0.15	0.093	YES
21	MCM8	MCM8	MCM8	2007	0.15	0.098	YES
22	CDKN1B	CDKN1B	CDKN1B	2068	0.14	0.1	YES
23	TYMS	TYMS	TYMS	2098	0.14	0.11	YES
24	DBF4	DBF4	DBF4	2115	0.14	0.11	YES
25	CENPI	CENPI	CENPI	2215	0.14	0.12	YES
26	ERCC6L	ERCC6L	ERCC6L	2253	0.14	0.12	YES
27	SKA1	SKA1	SKA1	2322	0.13	0.12	YES
28	CDC45	CDC45	CDC45	2381	0.13	0.13	YES
29	NEK2	NEK2	NEK2	2411	0.13	0.13	YES
30	KIF20A	KIF20A	KIF20A	2461	0.13	0.14	YES
31	KIF2C	KIF2C	KIF2C	2488	0.12	0.14	YES
32	CDCA8	CDCA8	CDCA8	2515	0.12	0.15	YES
33	CENPQ	CENPQ	CENPQ	2532	0.12	0.15	YES
34	KIF23	KIF23	KIF23	2543	0.12	0.16	YES
35	CDC26	CDC26	CDC26	2574	0.12	0.16	YES
36	INCENP	INCENP	INCENP	2608	0.12	0.17	YES
37	NUF2	NUF2	NUF2	2651	0.12	0.17	YES
38	CENPL	CENPL	CENPL	2652	0.12	0.18	YES
39	CDC25B	CDC25B	CDC25B	2737	0.11	0.18	YES
40	POLA1	POLA1	POLA1	2743	0.11	0.18	YES
41	GINS1	GINS1	GINS1	2779	0.11	0.19	YES
42	CCNB2	CCNB2	CCNB2	2786	0.11	0.19	YES
43	CDKN2D	CDKN2D	CDKN2D	2826	0.11	0.2	YES
44	CDKN2B	CDKN2B	CDKN2B	2868	0.11	0.2	YES
45	MAD2L1	MAD2L1	MAD2L1	2928	0.11	0.2	YES
46	CENPN	CENPN	CENPN	2965	0.1	0.2	YES
47	SGOL2	SGOL2	SGOL2	3007	0.1	0.21	YES
48	CDK2	CDK2	CDK2	3020	0.1	0.21	YES
49	CKAP5	CKAP5	CKAP5	3043	0.1	0.22	YES
50	LIN52	LIN52	LIN52	3087	0.1	0.22	YES
51	MLF1IP	MLF1IP	MLF1IP	3110	0.1	0.22	YES
52	SMC3	SMC3	SMC3	3164	0.098	0.22	YES
53	CDC20	CDC20	CDC20	3237	0.096	0.23	YES
54	UBE2C	UBE2C	UBE2C	3242	0.096	0.23	YES
55	BIRC5	BIRC5	BIRC5	3259	0.096	0.24	YES
56	POLE	POLE	POLE	3269	0.095	0.24	YES
57	CEP76	CEP76	CEP76	3273	0.095	0.24	YES
58	CDC25C	CDC25C	CDC25C	3339	0.092	0.24	YES
59	ANAPC2	ANAPC2	ANAPC2	3369	0.092	0.25	YES
60	SPC24	SPC24	SPC24	3390	0.091	0.25	YES
61	CEP135	CEP135	CEP135	3403	0.091	0.26	YES
62	AURKA	AURKA	AURKA	3404	0.091	0.26	YES
63	PPP2R5D	PPP2R5D	PPP2R5D	3425	0.09	0.26	YES
64	BUB1	BUB1	BUB1	3429	0.09	0.27	YES
65	CDK5RAP2	CDK5RAP2	CDK5RAP2	3432	0.09	0.27	YES
66	PLK1	PLK1	PLK1	3481	0.088	0.28	YES
67	PSMC3	PSMC3	PSMC3	3492	0.088	0.28	YES
68	CDC6	CDC6	CDC6	3547	0.086	0.28	YES
69	MAD1L1	MAD1L1	MAD1L1	3555	0.086	0.28	YES
70	PLK4	PLK4	PLK4	3567	0.086	0.29	YES
71	CENPC1	CENPC1	CENPC1	3616	0.085	0.29	YES
72	TUBGCP3	TUBGCP3	TUBGCP3	3633	0.084	0.29	YES
73	PSMC4	PSMC4	PSMC4	3677	0.083	0.3	YES
74	LIN54	LIN54	LIN54	3767	0.08	0.3	YES
75	RAD21	RAD21	RAD21	3786	0.08	0.3	YES
76	PSMD8	PSMD8	PSMD8	3801	0.08	0.3	YES
77	CCDC99	CCDC99	CCDC99	3828	0.079	0.3	YES
78	E2F4	E2F4	E2F4	3967	0.076	0.3	YES
79	GINS2	GINS2	GINS2	3981	0.076	0.3	YES
80	SDCCAG8	SDCCAG8	SDCCAG8	4111	0.073	0.3	YES
81	SEC13	SEC13	SEC13	4125	0.072	0.3	YES
82	STAG1	STAG1	STAG1	4184	0.071	0.3	YES
83	NINL	NINL	NINL	4199	0.071	0.31	YES
84	DCTN3	DCTN3	DCTN3	4217	0.07	0.31	YES
85	TUBG2	TUBG2	TUBG2	4262	0.069	0.31	YES
86	RBL1	RBL1	RBL1	4295	0.069	0.31	YES
87	FEN1	FEN1	FEN1	4315	0.068	0.31	YES
88	ALMS1	ALMS1	ALMS1	4432	0.066	0.31	YES
89	PRIM2	PRIM2	PRIM2	4446	0.066	0.31	YES
90	RRM2	RRM2	RRM2	4476	0.065	0.32	YES
91	E2F1	E2F1	E2F1	4500	0.064	0.32	YES
92	TUBGCP5	TUBGCP5	TUBGCP5	4524	0.064	0.32	YES
93	POLE2	POLE2	POLE2	4564	0.063	0.32	YES
94	KNTC1	KNTC1	KNTC1	4572	0.063	0.32	YES
95	PSMD3	PSMD3	PSMD3	4587	0.063	0.33	YES
96	CEP72	CEP72	CEP72	4597	0.062	0.33	YES
97	BUB3	BUB3	BUB3	4610	0.062	0.33	YES
98	LIN37	LIN37	LIN37	4622	0.062	0.33	YES
99	CEP192	CEP192	CEP192	4642	0.062	0.34	YES
100	PSMD13	PSMD13	PSMD13	4681	0.061	0.34	YES
101	MCM5	MCM5	MCM5	4718	0.06	0.34	YES
102	ZWILCH	ZWILCH	ZWILCH	4741	0.06	0.34	YES
103	RPA3	RPA3	RPA3	4798	0.059	0.34	YES
104	PSMD7	PSMD7	PSMD7	4800	0.059	0.34	YES
105	ZWINT	ZWINT	ZWINT	4805	0.059	0.35	YES
106	NEDD1	NEDD1	NEDD1	4884	0.057	0.34	YES
107	TFDP1	TFDP1	TFDP1	4949	0.056	0.34	YES
108	SKP2	SKP2	SKP2	4985	0.055	0.34	YES
109	RFC2	RFC2	RFC2	5038	0.054	0.34	YES
110	PSMB7	PSMB7	PSMB7	5067	0.054	0.35	YES
111	MCM6	MCM6	MCM6	5102	0.053	0.35	YES
112	RFC4	RFC4	RFC4	5137	0.053	0.35	YES
113	GMNN	GMNN	GMNN	5246	0.051	0.34	YES
114	CDT1	CDT1	CDT1	5272	0.05	0.35	YES
115	PTTG1	PTTG1	PTTG1	5285	0.05	0.35	YES
116	PSMB1	PSMB1	PSMB1	5290	0.05	0.35	YES
117	OFD1	OFD1	OFD1	5300	0.05	0.35	YES
118	AURKB	AURKB	AURKB	5304	0.05	0.36	YES
119	PAFAH1B1	PAFAH1B1	PAFAH1B1	5381	0.048	0.35	YES
120	LIN9	LIN9	LIN9	5412	0.048	0.35	YES
121	CSNK1E	CSNK1E	CSNK1E	5461	0.047	0.35	YES
122	SKA2	SKA2	SKA2	5467	0.047	0.36	YES
123	CDK4	CDK4	CDK4	5495	0.046	0.36	YES
124	CEP250	CEP250	CEP250	5588	0.045	0.35	YES
125	TUBGCP2	TUBGCP2	TUBGCP2	5659	0.044	0.35	YES
126	MYBL2	MYBL2	MYBL2	5662	0.044	0.35	YES
127	PCNA	PCNA	PCNA	5678	0.044	0.36	YES
128	CDC25A	CDC25A	CDC25A	5702	0.043	0.36	YES
129	CEP63	CEP63	CEP63	5717	0.043	0.36	YES
130	CDC27	CDC27	CDC27	5718	0.043	0.36	YES
131	PCNT	PCNT	PCNT	5941	0.04	0.35	NO
132	BUB1B	BUB1B	BUB1B	5954	0.039	0.35	NO
133	PSMA7	PSMA7	PSMA7	6019	0.038	0.35	NO
134	POLA2	POLA2	POLA2	6032	0.038	0.35	NO
135	NUP107	NUP107	NUP107	6038	0.038	0.35	NO
136	SSNA1	SSNA1	SSNA1	6086	0.037	0.35	NO
137	POLD1	POLD1	POLD1	6121	0.037	0.35	NO
138	AHCTF1	AHCTF1	AHCTF1	6213	0.035	0.35	NO
139	ITGB3BP	ITGB3BP	ITGB3BP	6223	0.035	0.35	NO
140	MCM10	MCM10	MCM10	6249	0.035	0.35	NO
141	PPP1CC	PPP1CC	PPP1CC	6295	0.034	0.35	NO
142	TK2	TK2	TK2	6308	0.034	0.35	NO
143	MCM2	MCM2	MCM2	6309	0.034	0.35	NO
144	RPA2	RPA2	RPA2	6388	0.032	0.35	NO
145	RPA1	RPA1	RPA1	6399	0.032	0.35	NO
146	STAG2	STAG2	STAG2	6410	0.032	0.35	NO
147	PSMD6	PSMD6	PSMD6	6423	0.032	0.35	NO
148	CEP70	CEP70	CEP70	6456	0.031	0.35	NO
149	SEH1L	SEH1L	SEH1L	6483	0.031	0.35	NO
150	NUP37	NUP37	NUP37	6627	0.029	0.35	NO
151	DYRK1A	DYRK1A	DYRK1A	6635	0.028	0.35	NO
152	RCC2	RCC2	RCC2	6638	0.028	0.35	NO
153	NUP43	NUP43	NUP43	6678	0.028	0.35	NO
154	PSMC2	PSMC2	PSMC2	6713	0.027	0.35	NO
155	CENPT	CENPT	CENPT	6748	0.027	0.35	NO
156	PSMF1	PSMF1	PSMF1	6801	0.026	0.35	NO
157	DYNC1H1	DYNC1H1	DYNC1H1	6803	0.026	0.35	NO
158	ANAPC7	ANAPC7	ANAPC7	6847	0.026	0.35	NO
159	CEP290	CEP290	CEP290	6907	0.025	0.34	NO
160	CDC16	CDC16	CDC16	6913	0.025	0.35	NO
161	PPP2R5C	PPP2R5C	PPP2R5C	6918	0.025	0.35	NO
162	RFC5	RFC5	RFC5	6994	0.024	0.34	NO
163	ACTR1A	ACTR1A	ACTR1A	7021	0.023	0.34	NO
164	PSMD10	PSMD10	PSMD10	7024	0.023	0.34	NO
165	PSMA2	PSMA2	PSMA2	7057	0.023	0.34	NO
166	TUBG1	TUBG1	TUBG1	7135	0.022	0.34	NO
167	DCTN2	DCTN2	DCTN2	7148	0.022	0.34	NO
168	CDC23	CDC23	CDC23	7177	0.021	0.34	NO
169	PSMB6	PSMB6	PSMB6	7210	0.021	0.34	NO
170	PMF1	PMF1	PMF1	7229	0.02	0.34	NO
171	PRKACA	PRKACA	PRKACA	7253	0.02	0.34	NO
172	PSMD2	PSMD2	PSMD2	7266	0.02	0.34	NO
173	PSMD11	PSMD11	PSMD11	7279	0.02	0.34	NO
174	TUBB	TUBB	TUBB	7285	0.02	0.34	NO
175	MCM7	MCM7	MCM7	7296	0.02	0.34	NO
176	MCM3	MCM3	MCM3	7306	0.02	0.34	NO
177	DCTN1	DCTN1	DCTN1	7341	0.019	0.34	NO
178	ANAPC4	ANAPC4	ANAPC4	7350	0.019	0.34	NO
179	CCNB1	CCNB1	CCNB1	7358	0.019	0.34	NO
180	DSN1	DSN1	DSN1	7371	0.018	0.34	NO
181	NUMA1	NUMA1	NUMA1	7414	0.018	0.34	NO
182	PSMA1	PSMA1	PSMA1	7436	0.018	0.34	NO
183	FGFR1OP	FGFR1OP	FGFR1OP	7452	0.018	0.34	NO
184	RANGAP1	RANGAP1	RANGAP1	7482	0.017	0.34	NO
185	DHFR	DHFR	DHFR	7489	0.017	0.34	NO
186	CDC7	CDC7	CDC7	7568	0.016	0.34	NO
187	NSL1	NSL1	NSL1	7591	0.016	0.34	NO
188	CENPH	CENPH	CENPH	7600	0.016	0.34	NO
189	DYNLL1	DYNLL1	DYNLL1	7642	0.015	0.34	NO
190	PSMD1	PSMD1	PSMD1	7682	0.015	0.34	NO
191	PPP2CA	PPP2CA	PPP2CA	7776	0.014	0.33	NO
192	CDK1	CDK1	CDK1	7814	0.013	0.33	NO
193	NUP85	NUP85	NUP85	7945	0.011	0.32	NO
194	PSMA4	PSMA4	PSMA4	7957	0.011	0.32	NO
195	HAUS2	HAUS2	HAUS2	7987	0.011	0.32	NO
196	E2F3	E2F3	E2F3	7994	0.011	0.32	NO
197	PSMD14	PSMD14	PSMD14	8020	0.01	0.32	NO
198	XPO1	XPO1	XPO1	8090	0.0091	0.32	NO
199	POLD3	POLD3	POLD3	8115	0.0089	0.32	NO
200	NUDC	NUDC	NUDC	8273	0.0068	0.31	NO
201	YWHAE	YWHAE	YWHAE	8286	0.0066	0.31	NO
202	YWHAG	YWHAG	YWHAG	8316	0.0062	0.31	NO
203	PSMC1	PSMC1	PSMC1	8323	0.006	0.31	NO
204	MAPRE1	MAPRE1	MAPRE1	8357	0.0056	0.31	NO
205	UBE2E1	UBE2E1	UBE2E1	8497	0.0038	0.3	NO
206	ANAPC5	ANAPC5	ANAPC5	8513	0.0036	0.3	NO
207	PSMB9	PSMB9	PSMB9	8528	0.0034	0.3	NO
208	TUBA1A	TUBA1A	TUBA1A	8550	0.0031	0.3	NO
209	CKS1B	CKS1B	CKS1B	8565	0.0028	0.3	NO
210	RBBP4	RBBP4	RBBP4	8637	0.002	0.29	NO
211	CEP164	CEP164	CEP164	8641	0.0019	0.29	NO
212	CENPJ	CENPJ	CENPJ	8712	0.00085	0.29	NO
213	BTRC	BTRC	BTRC	8845	-0.0006	0.28	NO
214	PPP2R5E	PPP2R5E	PPP2R5E	8930	-0.0017	0.28	NO
215	CUL1	CUL1	CUL1	8953	-0.0019	0.28	NO
216	PSMA3	PSMA3	PSMA3	8981	-0.0023	0.28	NO
217	HSP90AA1	HSP90AA1	HSP90AA1	8987	-0.0023	0.27	NO
218	CCNE1	CCNE1	CCNE1	9036	-0.003	0.27	NO
219	PSMB2	PSMB2	PSMB2	9105	-0.0038	0.27	NO
220	POLD2	POLD2	POLD2	9239	-0.0056	0.26	NO
221	RBL2	RBL2	RBL2	9268	-0.0061	0.26	NO
222	PSMD9	PSMD9	PSMD9	9296	-0.0065	0.26	NO
223	CCNH	CCNH	CCNH	9339	-0.007	0.26	NO
224	LIG1	LIG1	LIG1	9499	-0.009	0.25	NO
225	NUP133	NUP133	NUP133	9516	-0.0092	0.25	NO
226	MCM4	MCM4	MCM4	9529	-0.0093	0.25	NO
227	PSMC6	PSMC6	PSMC6	9566	-0.0099	0.25	NO
228	PSMB4	PSMB4	PSMB4	9664	-0.011	0.24	NO
229	CCND3	CCND3	CCND3	9829	-0.013	0.23	NO
230	PSMC5	PSMC5	PSMC5	9854	-0.013	0.23	NO
231	CLIP1	CLIP1	CLIP1	9924	-0.014	0.23	NO
232	SKP1	SKP1	SKP1	9965	-0.015	0.23	NO
233	NDEL1	NDEL1	NDEL1	10164	-0.017	0.22	NO
234	UBA52	UBA52	UBA52	10204	-0.018	0.22	NO
235	E2F2	E2F2	E2F2	10206	-0.018	0.22	NO
236	AZI1	AZI1	AZI1	10243	-0.018	0.22	NO
237	GORASP1	GORASP1	GORASP1	10321	-0.019	0.21	NO
238	PPP2R1A	PPP2R1A	PPP2R1A	10379	-0.02	0.21	NO
239	PSMB5	PSMB5	PSMB5	10454	-0.021	0.21	NO
240	MNAT1	MNAT1	MNAT1	10490	-0.022	0.21	NO
241	CLASP1	CLASP1	CLASP1	10585	-0.023	0.2	NO
242	MAX	MAX	MAX	10617	-0.023	0.2	NO
243	PSMA6	PSMA6	PSMA6	10746	-0.025	0.2	NO
244	PSMB3	PSMB3	PSMB3	10811	-0.026	0.2	NO
245	PSME2	PSME2	PSME2	10986	-0.029	0.19	NO
246	TAOK1	TAOK1	TAOK1	11044	-0.03	0.19	NO
247	AKAP9	AKAP9	AKAP9	11235	-0.032	0.18	NO
248	DYNC1I2	DYNC1I2	DYNC1I2	11303	-0.033	0.18	NO
249	PSME4	PSME4	PSME4	11425	-0.035	0.17	NO
250	PPP2R1B	PPP2R1B	PPP2R1B	11430	-0.036	0.17	NO
251	PSMD4	PSMD4	PSMD4	11490	-0.037	0.17	NO
252	PSMB8	PSMB8	PSMB8	11591	-0.039	0.17	NO
253	GINS4	GINS4	GINS4	11609	-0.039	0.17	NO
254	CETN2	CETN2	CETN2	11942	-0.044	0.15	NO
255	UBE2D1	UBE2D1	UBE2D1	11957	-0.045	0.16	NO
256	ANAPC11	ANAPC11	ANAPC11	11983	-0.045	0.16	NO
257	ANAPC1	ANAPC1	ANAPC1	11987	-0.045	0.16	NO
258	PCM1	PCM1	PCM1	12020	-0.046	0.16	NO
259	PSMD12	PSMD12	PSMD12	12043	-0.046	0.16	NO
260	HDAC1	HDAC1	HDAC1	12114	-0.048	0.16	NO
261	TUBGCP6	TUBGCP6	TUBGCP6	12297	-0.051	0.15	NO
262	DNA2	DNA2	DNA2	12364	-0.052	0.15	NO
263	ZW10	ZW10	ZW10	12386	-0.053	0.15	NO
264	WEE1	WEE1	WEE1	12424	-0.053	0.15	NO
265	PSMA5	PSMA5	PSMA5	12579	-0.057	0.15	NO
266	CSNK1D	CSNK1D	CSNK1D	12595	-0.057	0.15	NO
267	TUBA4A	TUBA4A	TUBA4A	12633	-0.057	0.15	NO
268	MIS12	MIS12	MIS12	12691	-0.059	0.15	NO
269	RFC3	RFC3	RFC3	12945	-0.064	0.14	NO
270	PPP2R5A	PPP2R5A	PPP2R5A	13062	-0.066	0.14	NO
271	CDK6	CDK6	CDK6	13149	-0.068	0.14	NO
272	KIF2A	KIF2A	KIF2A	13302	-0.072	0.13	NO
273	CEP57	CEP57	CEP57	13446	-0.075	0.13	NO
274	RANBP2	RANBP2	RANBP2	13540	-0.078	0.13	NO
275	PKMYT1	PKMYT1	PKMYT1	13586	-0.079	0.13	NO
276	RPS27A	RPS27A	RPS27A	13660	-0.081	0.13	NO
277	CENPK	CENPK	CENPK	13704	-0.082	0.13	NO
278	PPP2R2A	PPP2R2A	PPP2R2A	13749	-0.083	0.13	NO
279	PSME1	PSME1	PSME1	14099	-0.093	0.12	NO
280	POLD4	POLD4	POLD4	14192	-0.096	0.12	NO
281	PSMD5	PSMD5	PSMD5	14232	-0.097	0.12	NO
282	CCNA1	CCNA1	CCNA1	14312	-0.099	0.12	NO
283	PRKAR2B	PRKAR2B	PRKAR2B	14367	-0.1	0.12	NO
284	CCND1	CCND1	CCND1	14514	-0.11	0.12	NO
285	PPP2CB	PPP2CB	PPP2CB	14713	-0.11	0.12	NO
286	B9D2	B9D2	B9D2	15050	-0.12	0.1	NO
287	CENPM	CENPM	CENPM	15068	-0.13	0.11	NO
288	MYC	MYC	MYC	15517	-0.15	0.092	NO
289	CDKN1A	CDKN1A	CDKN1A	15730	-0.16	0.088	NO
290	CDK7	CDK7	CDK7	15848	-0.16	0.09	NO
291	RB1	RB1	RB1	15924	-0.16	0.095	NO
292	PSMB10	PSMB10	PSMB10	16018	-0.17	0.098	NO
293	CCND2	CCND2	CCND2	16505	-0.2	0.082	NO
294	E2F5	E2F5	E2F5	16623	-0.2	0.086	NO
295	CDC14A	CDC14A	CDC14A	16627	-0.2	0.096	NO
296	RPS27	RPS27	RPS27	17443	-0.27	0.066	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	NEK2	NEK2	NEK2	2411	0.13	-0.08	YES
2	CKAP5	CKAP5	CKAP5	3043	0.1	-0.075	YES
3	CEP76	CEP76	CEP76	3273	0.095	-0.05	YES
4	CEP135	CEP135	CEP135	3403	0.091	-0.022	YES
5	CDK5RAP2	CDK5RAP2	CDK5RAP2	3432	0.09	0.011	YES
6	PLK1	PLK1	PLK1	3481	0.088	0.042	YES
7	PLK4	PLK4	PLK4	3567	0.086	0.07	YES
8	TUBGCP3	TUBGCP3	TUBGCP3	3633	0.084	0.099	YES
9	SDCCAG8	SDCCAG8	SDCCAG8	4111	0.073	0.1	YES
10	NINL	NINL	NINL	4199	0.071	0.12	YES
11	DCTN3	DCTN3	DCTN3	4217	0.07	0.15	YES
12	TUBG2	TUBG2	TUBG2	4262	0.069	0.17	YES
13	ALMS1	ALMS1	ALMS1	4432	0.066	0.19	YES
14	TUBGCP5	TUBGCP5	TUBGCP5	4524	0.064	0.21	YES
15	CEP72	CEP72	CEP72	4597	0.062	0.23	YES
16	CEP192	CEP192	CEP192	4642	0.062	0.25	YES
17	NEDD1	NEDD1	NEDD1	4884	0.057	0.26	YES
18	OFD1	OFD1	OFD1	5300	0.05	0.26	YES
19	PAFAH1B1	PAFAH1B1	PAFAH1B1	5381	0.048	0.27	YES
20	CSNK1E	CSNK1E	CSNK1E	5461	0.047	0.29	YES
21	CEP250	CEP250	CEP250	5588	0.045	0.3	YES
22	TUBGCP2	TUBGCP2	TUBGCP2	5659	0.044	0.31	YES
23	CEP63	CEP63	CEP63	5717	0.043	0.32	YES
24	PCNT	PCNT	PCNT	5941	0.04	0.33	YES
25	SSNA1	SSNA1	SSNA1	6086	0.037	0.33	YES
26	CEP70	CEP70	CEP70	6456	0.031	0.32	YES
27	DYNC1H1	DYNC1H1	DYNC1H1	6803	0.026	0.32	YES
28	CEP290	CEP290	CEP290	6907	0.025	0.32	YES
29	ACTR1A	ACTR1A	ACTR1A	7021	0.023	0.32	YES
30	TUBG1	TUBG1	TUBG1	7135	0.022	0.32	YES
31	DCTN2	DCTN2	DCTN2	7148	0.022	0.33	YES
32	PRKACA	PRKACA	PRKACA	7253	0.02	0.34	YES
33	TUBB	TUBB	TUBB	7285	0.02	0.34	YES
34	DCTN1	DCTN1	DCTN1	7341	0.019	0.34	YES
35	CCNB1	CCNB1	CCNB1	7358	0.019	0.35	YES
36	NUMA1	NUMA1	NUMA1	7414	0.018	0.36	YES
37	FGFR1OP	FGFR1OP	FGFR1OP	7452	0.018	0.36	YES
38	DYNLL1	DYNLL1	DYNLL1	7642	0.015	0.36	NO
39	CDK1	CDK1	CDK1	7814	0.013	0.35	NO
40	HAUS2	HAUS2	HAUS2	7987	0.011	0.35	NO
41	YWHAE	YWHAE	YWHAE	8286	0.0066	0.33	NO
42	YWHAG	YWHAG	YWHAG	8316	0.0062	0.33	NO
43	MAPRE1	MAPRE1	MAPRE1	8357	0.0056	0.33	NO
44	TUBA1A	TUBA1A	TUBA1A	8550	0.0031	0.32	NO
45	CEP164	CEP164	CEP164	8641	0.0019	0.32	NO
46	CENPJ	CENPJ	CENPJ	8712	0.00085	0.32	NO
47	HSP90AA1	HSP90AA1	HSP90AA1	8987	-0.0023	0.3	NO
48	AZI1	AZI1	AZI1	10243	-0.018	0.24	NO
49	PPP2R1A	PPP2R1A	PPP2R1A	10379	-0.02	0.24	NO
50	CLASP1	CLASP1	CLASP1	10585	-0.023	0.24	NO
51	AKAP9	AKAP9	AKAP9	11235	-0.032	0.22	NO
52	DYNC1I2	DYNC1I2	DYNC1I2	11303	-0.033	0.23	NO
53	CETN2	CETN2	CETN2	11942	-0.044	0.21	NO
54	PCM1	PCM1	PCM1	12020	-0.046	0.22	NO
55	TUBGCP6	TUBGCP6	TUBGCP6	12297	-0.051	0.23	NO
56	CSNK1D	CSNK1D	CSNK1D	12595	-0.057	0.24	NO
57	TUBA4A	TUBA4A	TUBA4A	12633	-0.057	0.26	NO
58	CEP57	CEP57	CEP57	13446	-0.075	0.24	NO
59	PRKAR2B	PRKAR2B	PRKAR2B	14367	-0.1	0.23	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	FBXO6	FBXO6	FBXO6	1980	0.15	-0.033	YES
2	TUBA3C	TUBA3C	TUBA3C	2265	0.14	0.019	YES
3	FBXO4	FBXO4	FBXO4	2321	0.13	0.082	YES
4	FKBP9	FKBP9	FKBP9	2379	0.13	0.14	YES
5	USP11	USP11	USP11	3652	0.084	0.12	YES
6	TUBB1	TUBB1	TUBB1	3791	0.08	0.15	YES
7	KIF13A	KIF13A	KIF13A	3813	0.079	0.19	YES
8	VBP1	VBP1	VBP1	4012	0.074	0.21	YES
9	FBXW2	FBXW2	FBXW2	4178	0.071	0.24	YES
10	TUBB6	TUBB6	TUBB6	4290	0.069	0.27	YES
11	TBCB	TBCB	TBCB	4428	0.066	0.29	YES
12	TUBB2A	TUBB2A	TUBB2A	4464	0.065	0.32	YES
13	FBXW5	FBXW5	FBXW5	5269	0.05	0.3	YES
14	TUBA1B	TUBA1B	TUBA1B	5391	0.048	0.32	YES
15	XRN2	XRN2	XRN2	5480	0.047	0.34	YES
16	FBXL3	FBXL3	FBXL3	5916	0.04	0.34	YES
17	TCP1	TCP1	TCP1	6224	0.035	0.34	YES
18	FBXW7	FBXW7	FBXW7	6314	0.034	0.35	YES
19	PFDN4	PFDN4	PFDN4	6556	0.03	0.35	YES
20	NOP56	NOP56	NOP56	6577	0.029	0.36	YES
21	PFDN1	PFDN1	PFDN1	6712	0.027	0.37	YES
22	KIFC3	KIFC3	KIFC3	6816	0.026	0.38	YES
23	TBCD	TBCD	TBCD	7092	0.022	0.37	NO
24	CCT4	CCT4	CCT4	7656	0.015	0.35	NO
25	CCT5	CCT5	CCT5	7854	0.012	0.35	NO
26	PFDN2	PFDN2	PFDN2	8066	0.0094	0.34	NO
27	ACTB	ACTB	ACTB	8209	0.0076	0.34	NO
28	CCT6A	CCT6A	CCT6A	8420	0.0048	0.33	NO
29	CCT2	CCT2	CCT2	8545	0.0032	0.32	NO
30	TUBA1A	TUBA1A	TUBA1A	8550	0.0031	0.32	NO
31	CCT8	CCT8	CCT8	8671	0.0014	0.32	NO
32	TUBB3	TUBB3	TUBB3	8700	0.001	0.32	NO
33	TUBA1C	TUBA1C	TUBA1C	8947	-0.0018	0.3	NO
34	CCT7	CCT7	CCT7	9207	-0.0051	0.29	NO
35	CCT3	CCT3	CCT3	9334	-0.007	0.29	NO
36	TBCE	TBCE	TBCE	9345	-0.0071	0.29	NO
37	FBXL5	FBXL5	FBXL5	9627	-0.011	0.28	NO
38	ARFGEF2	ARFGEF2	ARFGEF2	9747	-0.012	0.28	NO
39	PFDN5	PFDN5	PFDN5	9806	-0.013	0.28	NO
40	LONP2	LONP2	LONP2	10116	-0.017	0.28	NO
41	TBCC	TBCC	TBCC	10350	-0.02	0.27	NO
42	PFDN6	PFDN6	PFDN6	10569	-0.023	0.27	NO
43	TUBA3D	TUBA3D	TUBA3D	10766	-0.025	0.28	NO
44	FBXW4	FBXW4	FBXW4	10831	-0.026	0.29	NO
45	TBCA	TBCA	TBCA	11302	-0.033	0.28	NO
46	AP3M1	AP3M1	AP3M1	11628	-0.039	0.28	NO
47	TUBB2B	TUBB2B	TUBB2B	11833	-0.043	0.29	NO
48	TUBA4A	TUBA4A	TUBA4A	12633	-0.057	0.28	NO
49	SPHK1	SPHK1	SPHK1	14283	-0.098	0.24	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	CDKN2C	CDKN2C	CDKN2C	154	0.43	0.04	YES
2	CCNB3	CCNB3	CCNB3	211	0.4	0.082	YES
3	TGFB2	TGFB2	TGFB2	923	0.24	0.07	YES
4	TGFB3	TGFB3	TGFB3	997	0.23	0.092	YES
5	CCNE2	CCNE2	CCNE2	1344	0.19	0.096	YES
6	CDKN2A	CDKN2A	CDKN2A	1834	0.16	0.087	YES
7	CCNA2	CCNA2	CCNA2	1868	0.16	0.1	YES
8	SMC1A	SMC1A	SMC1A	1894	0.15	0.12	YES
9	ANAPC10	ANAPC10	ANAPC10	1952	0.15	0.13	YES
10	CDKN1B	CDKN1B	CDKN1B	2068	0.14	0.14	YES
11	DBF4	DBF4	DBF4	2115	0.14	0.16	YES
12	CDC45	CDC45	CDC45	2381	0.13	0.16	YES
13	CDC26	CDC26	CDC26	2574	0.12	0.16	YES
14	TGFB1	TGFB1	TGFB1	2713	0.12	0.16	YES
15	SMAD3	SMAD3	SMAD3	2728	0.12	0.18	YES
16	CDC25B	CDC25B	CDC25B	2737	0.11	0.19	YES
17	CCNB2	CCNB2	CCNB2	2786	0.11	0.2	YES
18	CDKN2D	CDKN2D	CDKN2D	2826	0.11	0.21	YES
19	CDKN2B	CDKN2B	CDKN2B	2868	0.11	0.22	YES
20	MAD2L1	MAD2L1	MAD2L1	2928	0.11	0.23	YES
21	CDK2	CDK2	CDK2	3020	0.1	0.24	YES
22	MAD2L2	MAD2L2	MAD2L2	3099	0.1	0.24	YES
23	SMC3	SMC3	SMC3	3164	0.098	0.25	YES
24	ESPL1	ESPL1	ESPL1	3191	0.098	0.26	YES
25	CDC20	CDC20	CDC20	3237	0.096	0.27	YES
26	CDC25C	CDC25C	CDC25C	3339	0.092	0.27	YES
27	ANAPC2	ANAPC2	ANAPC2	3369	0.092	0.28	YES
28	BUB1	BUB1	BUB1	3429	0.09	0.29	YES
29	SMC1B	SMC1B	SMC1B	3472	0.088	0.3	YES
30	PLK1	PLK1	PLK1	3481	0.088	0.3	YES
31	CDC6	CDC6	CDC6	3547	0.086	0.31	YES
32	MAD1L1	MAD1L1	MAD1L1	3555	0.086	0.32	YES
33	TTK	TTK	TTK	3730	0.082	0.32	YES
34	RAD21	RAD21	RAD21	3786	0.08	0.33	YES
35	E2F4	E2F4	E2F4	3967	0.076	0.32	YES
36	ABL1	ABL1	ABL1	3974	0.076	0.33	YES
37	TP53	TP53	TP53	4180	0.071	0.33	YES
38	STAG1	STAG1	STAG1	4184	0.071	0.34	YES
39	RBL1	RBL1	RBL1	4295	0.069	0.34	YES
40	E2F1	E2F1	E2F1	4500	0.064	0.34	YES
41	FZR1	FZR1	FZR1	4517	0.064	0.34	YES
42	BUB3	BUB3	BUB3	4610	0.062	0.34	YES
43	MCM5	MCM5	MCM5	4718	0.06	0.35	YES
44	CDC14B	CDC14B	CDC14B	4749	0.06	0.35	YES
45	TFDP1	TFDP1	TFDP1	4949	0.056	0.35	YES
46	SKP2	SKP2	SKP2	4985	0.055	0.35	YES
47	MCM6	MCM6	MCM6	5102	0.053	0.35	YES
48	SMAD2	SMAD2	SMAD2	5268	0.05	0.35	YES
49	PTTG1	PTTG1	PTTG1	5285	0.05	0.35	YES
50	HDAC2	HDAC2	HDAC2	5294	0.05	0.36	YES
51	CDK4	CDK4	CDK4	5495	0.046	0.35	NO
52	PCNA	PCNA	PCNA	5678	0.044	0.35	NO
53	CDC25A	CDC25A	CDC25A	5702	0.043	0.35	NO
54	CDC27	CDC27	CDC27	5718	0.043	0.35	NO
55	CREBBP	CREBBP	CREBBP	5900	0.04	0.35	NO
56	BUB1B	BUB1B	BUB1B	5954	0.039	0.35	NO
57	PRKDC	PRKDC	PRKDC	6214	0.035	0.34	NO
58	SMAD4	SMAD4	SMAD4	6296	0.034	0.34	NO
59	MCM2	MCM2	MCM2	6309	0.034	0.34	NO
60	STAG2	STAG2	STAG2	6410	0.032	0.34	NO
61	ZBTB17	ZBTB17	ZBTB17	6580	0.029	0.34	NO
62	GADD45A	GADD45A	GADD45A	6686	0.028	0.33	NO
63	YWHAH	YWHAH	YWHAH	6823	0.026	0.33	NO
64	ANAPC7	ANAPC7	ANAPC7	6847	0.026	0.33	NO
65	ATR	ATR	ATR	6912	0.025	0.33	NO
66	CDC16	CDC16	CDC16	6913	0.025	0.33	NO
67	MDM2	MDM2	MDM2	7163	0.021	0.32	NO
68	CDC23	CDC23	CDC23	7177	0.021	0.32	NO
69	MCM7	MCM7	MCM7	7296	0.02	0.32	NO
70	MCM3	MCM3	MCM3	7306	0.02	0.32	NO
71	ANAPC4	ANAPC4	ANAPC4	7350	0.019	0.32	NO
72	CCNB1	CCNB1	CCNB1	7358	0.019	0.32	NO
73	GADD45B	GADD45B	GADD45B	7370	0.018	0.32	NO
74	ANAPC13	ANAPC13	ANAPC13	7400	0.018	0.32	NO
75	CDC7	CDC7	CDC7	7568	0.016	0.32	NO
76	CDK1	CDK1	CDK1	7814	0.013	0.3	NO
77	EP300	EP300	EP300	7897	0.012	0.3	NO
78	E2F3	E2F3	E2F3	7994	0.011	0.3	NO
79	YWHAB	YWHAB	YWHAB	8046	0.0097	0.3	NO
80	SFN	SFN	SFN	8199	0.0078	0.29	NO
81	GSK3B	GSK3B	GSK3B	8251	0.007	0.29	NO
82	YWHAE	YWHAE	YWHAE	8286	0.0066	0.29	NO
83	YWHAG	YWHAG	YWHAG	8316	0.0062	0.28	NO
84	ANAPC5	ANAPC5	ANAPC5	8513	0.0036	0.28	NO
85	RBX1	RBX1	RBX1	8837	-0.0005	0.26	NO
86	CUL1	CUL1	CUL1	8953	-0.0019	0.25	NO
87	CCNE1	CCNE1	CCNE1	9036	-0.003	0.25	NO
88	RBL2	RBL2	RBL2	9268	-0.0061	0.24	NO
89	CCNH	CCNH	CCNH	9339	-0.007	0.23	NO
90	TFDP2	TFDP2	TFDP2	9487	-0.0089	0.23	NO
91	MCM4	MCM4	MCM4	9529	-0.0093	0.22	NO
92	CHEK2	CHEK2	CHEK2	9591	-0.01	0.22	NO
93	CCND3	CCND3	CCND3	9829	-0.013	0.21	NO
94	SKP1	SKP1	SKP1	9965	-0.015	0.2	NO
95	E2F2	E2F2	E2F2	10206	-0.018	0.19	NO
96	WEE2	WEE2	WEE2	10353	-0.02	0.19	NO
97	YWHAQ	YWHAQ	YWHAQ	11214	-0.032	0.15	NO
98	YWHAZ	YWHAZ	YWHAZ	11458	-0.036	0.14	NO
99	PTTG2	PTTG2	PTTG2	11960	-0.045	0.12	NO
100	CDKN1C	CDKN1C	CDKN1C	11972	-0.045	0.12	NO
101	ANAPC11	ANAPC11	ANAPC11	11983	-0.045	0.12	NO
102	ANAPC1	ANAPC1	ANAPC1	11987	-0.045	0.13	NO
103	HDAC1	HDAC1	HDAC1	12114	-0.048	0.13	NO
104	WEE1	WEE1	WEE1	12424	-0.053	0.12	NO
105	CDK6	CDK6	CDK6	13149	-0.068	0.085	NO
106	PKMYT1	PKMYT1	PKMYT1	13586	-0.079	0.07	NO
107	CCNA1	CCNA1	CCNA1	14312	-0.099	0.042	NO
108	CHEK1	CHEK1	CHEK1	14381	-0.1	0.05	NO
109	CCND1	CCND1	CCND1	14514	-0.11	0.055	NO
110	GADD45G	GADD45G	GADD45G	14960	-0.12	0.045	NO
111	ATM	ATM	ATM	15287	-0.14	0.042	NO
112	MYC	MYC	MYC	15517	-0.15	0.046	NO
113	CDKN1A	CDKN1A	CDKN1A	15730	-0.16	0.052	NO
114	CDK7	CDK7	CDK7	15848	-0.16	0.064	NO
115	RB1	RB1	RB1	15924	-0.16	0.079	NO
116	CCND2	CCND2	CCND2	16505	-0.2	0.07	NO
117	E2F5	E2F5	E2F5	16623	-0.2	0.086	NO
118	CDC14A	CDC14A	CDC14A	16627	-0.2	0.11	NO