Clustering of copy number data by peak region with threshold value: consensus NMF
Uveal Melanoma (Primary solid tumor)
28 January 2016
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analyses__2016_01_28
Maintainer Information
Citation Information
Maintained by Hailei Zhang
(Broad Institute)
Cite as
Broad Institute TCGA Genome Data Analysis Center
(2016):
Clustering of copy number data by peak region with threshold value: consensus NMF.
Broad Institute of MIT and Harvard.
doi:10.7908/C1ZP45NR
Overview
Introduction
Summary
The most robust consensus NMF clustering of 80 samples using the 21 copy number focal regions was identified for k = 8 clusters. We computed the clustering for k = 2 to k = 8 and used the cophenetic correlation coefficient to determine the best solution.
Results
Copy number focal events of molecular subtypes
Silhouette widths, Cophenetic Correlation Coefficients and Consensus matrix
Samples assignment with silhouette width
Marker focal events of each subtype
Methods & Data
Copyright © 2016
Broad Institute TCGA GDAC as part of the TCGA Research Network.
All rights reserved.