rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	25	ABL1(2), ATM(5), ATR(4), CCNA1(1), CCND1(1), CDK4(1), CDKN1A(2), CDKN2A(1), RB1(24), TFDP1(1), TGFB1(1), TP53(90)	10950702	133	106	118	7	13	13	16	24	65	2	8.89e-08	<1.00e-15	<1.03e-13
2	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	12	ATM(5), CDC25B(1), CDK4(1), MYT1(2), RB1(24), TP53(90)	6350812	123	100	108	8	10	16	14	20	61	2	5.74e-06	<1.00e-15	<1.03e-13
3	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	22	ATM(5), ATR(4), CDC25B(1), CDKN1A(2), CDKN2D(1), CHEK2(2), EP300(2), MDM2(1), MYT1(2), PRKDC(5), RPS6KA1(1), TP53(90)	15759879	116	95	101	13	11	20	14	26	45	0	0.000443	<1.00e-15	<1.03e-13
4	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	20	ATM(5), PRKCA(1), PTK2(3), STAT1(2), TLN1(2), TP53(90)	10014396	103	90	88	6	11	14	14	21	43	0	4.56e-06	<1.00e-15	<1.03e-13
5	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	19	ATM(5), CDKN1A(2), HIC1(1), MDM2(1), TP53(90)	7574022	99	89	84	11	11	14	12	22	40	0	0.00120	<1.00e-15	<1.03e-13
6	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	7	ATM(5), ATR(4), CHEK2(2), TP53(90)	5754609	101	88	86	5	10	15	12	22	42	0	2.36e-05	<1.00e-15	<1.03e-13
7	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	18	IFNG(1), LIN7A(1), NFKB1(1), RB1(24), RELA(2), TNF(1), TNFRSF1A(1), TP53(90), USH1C(2)	6700890	123	100	108	6	14	15	12	20	60	2	2.30e-08	1.55e-15	1.23e-13
8	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	42	FAS(1), MAP2K4(2), MAPK10(2), MDM2(1), MYC(3), NFKB1(1), RELA(2), RIPK1(2), TNF(1), TNFRSF1A(1), TP53(90), TRAF2(2)	13731663	108	92	93	11	14	18	11	22	43	0	4.96e-05	1.78e-15	1.23e-13
9	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	21	ATM(5), ATR(4), BRCA2(2), CHEK2(2), FANCC(2), RAD17(1), RAD50(2), TP53(90)	15765036	108	94	93	7	10	17	12	24	44	1	3.06e-05	1.89e-15	1.23e-13
10	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	13	CREBBP(4), PML(1), RARA(1), RB1(24), SIRT1(1), TNF(1), TNFRSF1A(1), TP53(90)	6775135	123	98	108	5	14	13	11	20	63	2	7.17e-09	2.00e-15	1.23e-13
11	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	16	ABL1(2), CDKN2A(1), MDM2(1), MYC(3), PIK3CA(6), PIK3R1(1), RAC1(1), RB1(24), TP53(90), TWIST1(1)	7284112	130	103	114	6	13	14	12	24	65	2	9.01e-09	3.22e-15	1.54e-13
12	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(1), CUL1(3), RB1(24), TFDP1(1)	3165827	29	28	29	1	2	0	2	1	22	2	0.00756	3.44e-15	1.54e-13
13	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	7	MYC(3), SP1(2), SP3(2), TP53(90)	2491106	97	89	82	3	11	14	11	20	41	0	5.13e-08	3.55e-15	1.54e-13
14	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	16	ATM(5), CCND1(1), CDK4(1), CDKN1A(2), MDM2(1), RB1(24), TP53(90)	6576060	124	102	109	6	12	13	14	22	61	2	2.85e-07	3.77e-15	1.54e-13
15	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	15	EGFR(2), IGF1R(1), MYC(3), PRKCA(1), RB1(24), TEP1(2), TERF1(2), TERT(1), TP53(90)	10215409	126	102	111	6	13	14	12	20	65	2	9.74e-09	3.77e-15	1.54e-13
16	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	65	ATM(5), ATR(4), BAI1(3), CCNB3(1), CCND1(1), CDK4(1), CDKN1A(2), CDKN2A(1), CHEK2(2), DDB2(1), FAS(1), GTSE1(1), IGF1(1), MDM2(1), PTEN(8), RRM2(1), THBS1(1), TP53(90), TSC2(4), ZMAT3(1)	24162394	130	103	115	10	15	18	15	33	49	0	1.23e-06	4.00e-15	1.54e-13
17	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CUL1(3), NEDD8(1), RB1(24), TFDP1(1)	3122551	29	28	29	1	2	0	1	1	23	2	0.00782	4.66e-15	1.69e-13
18	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	15	CCND1(1), CDK4(1), CDKN1A(2), CDKN2A(1), MDM2(1), TP53(90)	2995120	96	90	81	4	12	12	11	21	40	0	1.21e-07	5.33e-15	1.80e-13
19	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	9	EIF2S2(1), NFKB1(1), RELA(2), TP53(90)	3662604	94	88	79	4	12	14	10	19	39	0	1.06e-06	5.55e-15	1.80e-13
20	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	38	GAB1(1), MAP2K4(2), MAP2K5(1), MAP2K7(2), MAP3K11(1), MAP3K13(1), MAP3K5(4), MAP3K7(1), MAP3K9(2), MAPK10(2), MAPK7(1), PAPPA(6), TP53(90), TRAF6(2), ZAK(1)	18355819	117	94	102	11	13	21	15	27	41	0	1.60e-05	6.33e-15	1.95e-13
21	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	65	ATM(5), CCNA1(1), CCND1(1), CCNH(1), CDK4(1), CDKN1A(2), CDKN2A(1), CDKN2D(1), CREB3L3(1), E2F3(1), E2F4(2), E2F6(1), GBA2(3), MCM3(1), MCM4(1), MCM5(1), MCM7(1), MDM2(1), MYC(3), MYT1(2), NACA(2), POLE(5), RB1(24), RPA1(1), TFDP1(1), TFDP2(1), TNXB(6), TP53(90)	28261674	161	114	146	17	19	25	20	29	66	2	1.20e-06	6.88e-15	2.02e-13
22	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	19	ABL1(2), ATM(5), CDKN1A(2), CHEK2(2), MDM2(1), NFKB1(1), RAD50(2), RBBP8(1), RELA(2), TP53(90)	10708078	108	94	93	9	13	19	12	23	41	0	6.50e-05	7.33e-15	2.05e-13
23	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	MAP2K2(1), MAP2K3(2), MAP2K6(2), MAPK1(1), NFKB1(1), PIK3CA(6), PIK3R1(1), RB1(24), RELA(2), SP1(2)	7186285	42	39	41	2	3	3	4	6	24	2	0.00282	8.55e-15	2.29e-13
24	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	RB1(24), SP1(2), SP3(2)	2310880	28	27	28	0	0	1	2	1	22	2	0.00771	1.08e-14	2.76e-13
25	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CUL1(3), RB1(24), TFDP1(1)	3079847	28	27	28	2	2	0	1	1	22	2	0.0358	1.27e-14	3.12e-13
26	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCNA1(1), CCND1(1), CCNH(1), CDK4(1), CDKN1A(2), CDKN2A(1), CDKN2D(1), RB1(24), TFDP1(1)	5896485	33	32	33	1	2	1	4	2	22	2	0.00293	2.63e-14	6.23e-13
27	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	CCND1(1), CDK4(1), CDKN1A(2), MAPK1(1), NFKB1(1), PAK1(1), PIK3CA(6), PIK3R1(1), RAC1(1), RB1(24), RELA(2), TFDP1(1)	7421357	42	40	41	3	4	3	4	5	24	2	0.00570	2.80e-13	6.38e-12
28	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	58	ALG2(1), BFAR(2), BTK(1), DEDD(1), EGFR(2), EPHB2(1), FAF1(1), IL1A(1), MAP2K4(2), MAP2K7(2), MAP3K5(4), MAPK1(1), MAPK10(2), MAPK8IP3(2), MET(4), NFAT5(4), NFKB1(1), NFKBIL1(1), PFN2(1), RIPK1(2), ROCK1(1), TP53(90), TPX2(1), TRAF2(2)	26982017	130	105	115	12	15	27	15	26	47	0	3.04e-06	3.11e-13	6.83e-12
29	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	67	BNIP3L(1), CASP4(2), FAS(1), HELLS(1), IRF2(1), IRF3(1), IRF5(1), IRF6(1), MAP2K4(2), MAPK10(2), MDM2(1), MYC(3), NFKB1(1), PLEKHG5(3), RELA(2), RIPK1(2), TNF(1), TNFRSF1A(1), TNFRSF21(3), TP53(90), TRAF2(2)	21128927	122	97	107	16	16	22	12	24	48	0	0.000229	5.55e-13	1.18e-11
30	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	82	AIFM1(1), ATM(5), CAPN1(1), CSF2RB(2), FAS(1), IL1A(1), IRAK2(1), IRAK3(2), NFKB1(1), NTRK1(3), PIK3CA(6), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(1), PIK3R3(1), PPP3CC(2), PRKACA(2), PRKAR2B(1), RELA(2), RIPK1(2), TNF(1), TNFRSF10D(1), TNFRSF1A(1), TP53(90), TRAF2(2)	31055363	134	106	118	14	20	19	19	28	48	0	2.24e-05	1.49e-11	3.05e-10
31	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	82	ABL1(2), ATM(5), BUB1B(1), CCNA1(1), CCNB3(1), CCNH(1), CDC25B(1), CDK4(1), CDKN1A(2), CDKN2A(1), CHEK2(2), DTX4(1), E2F3(1), E2F4(2), E2F6(1), EP300(2), ESPL1(2), HDAC3(1), HDAC5(1), HDAC6(2), MCM3(1), MCM4(1), MCM5(1), MCM7(1), MDM2(1), MPEG1(1), PRKDC(5), PTPRA(1), PTTG1(1), RB1(24), TFDP1(1), TGFB1(1), TP53(90)	40904430	160	115	145	20	17	23	20	30	68	2	3.12e-05	3.65e-07	7.24e-06
32	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	BAG4(1), LMNB1(1), MADD(1), MAP2K4(2), MAP3K7(1), PAK1(1), PRKDC(5), RB1(24), RIPK1(2), SPTAN1(3), TNF(1), TNFRSF1A(1), TRAF2(2)	14629503	45	41	45	4	3	5	6	1	28	2	0.00880	4.46e-06	8.58e-05
33	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	110	ABL1(2), ANAPC1(2), ANAPC2(2), ANAPC4(1), ANAPC5(1), ATM(5), ATR(4), BUB1B(1), CCNA1(1), CCNB3(1), CCND1(1), CCNH(1), CDC25B(1), CDK4(1), CDKN1A(2), CDKN2A(1), CDKN2D(1), CHEK2(2), CREBBP(4), CUL1(3), DBF4(2), E2F3(1), EP300(2), ESPL1(2), FZR1(2), MCM3(1), MCM4(1), MCM5(1), MCM7(1), MDM2(1), PRKDC(5), PTTG1(1), RB1(24), SMAD3(1), TFDP1(1), TGFB1(1), TP53(90), YWHAE(1)	50392264	175	122	160	21	19	26	20	33	75	2	1.74e-05	4.62e-06	8.63e-05
34	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	PIK3CA(6), PIK3R1(1), PLCB1(4), PLCG1(2), PRKCA(1), VAV1(3)	4737732	17	15	16	1	2	2	1	8	4	0	0.0650	0.000605	0.0110
35	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	FAF1(1), LMNB1(1), MAP2K4(2), MAP3K7(1), PAK1(1), PRKDC(5), RB1(24), RIPK2(1), SPTAN1(3)	15686920	39	38	39	6	1	3	4	2	27	2	0.165	0.00156	0.0275
36	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	BCAR1(1), MAPK1(1), PIK3CA(6), PIK3R1(1), PTEN(8), PTK2(3)	7122146	20	18	19	1	2	1	3	9	5	0	0.0623	0.00206	0.0352
37	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	AGT(1), AGTR1(1), AGTR2(1), COL4A1(5), COL4A2(2), COL4A3(6), COL4A4(4), COL4A5(3), COL4A6(4), REN(1)	9388634	28	22	27	1	0	11	5	4	8	0	0.00309	0.00253	0.0421
38	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	BCAR1(1), MAPK1(1), NFKB1(1), PIK3C2G(7), PIK3CA(6), PIK3R1(1), PLCG1(2), PRKCA(1), PTK2(3), PTK2B(2), RELA(2)	10391282	27	26	26	2	2	4	5	8	8	0	0.0288	0.00282	0.0457
39	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(2), TAT(2), TYR(2)	1674708	6	6	6	0	2	2	1	0	1	0	0.161	0.00446	0.0705
40	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(2), CYP2C9(2)	744539	4	4	4	1	1	1	2	0	0	0	0.595	0.00776	0.120
41	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(2), JAK1(1), JAK3(2), PIAS1(2), PTPRU(7), SOAT1(1)	5204455	15	14	15	2	3	2	4	4	2	0	0.187	0.00870	0.131
42	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	EIF2S2(1), IGF1(1), IGF1R(1), INPPL1(1), PIK3CA(6), PIK3R1(1), PTEN(8)	7336935	19	16	18	0	3	2	1	9	4	0	0.00969	0.00979	0.144
43	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	DPM2(1), NTRK1(3), PIK3CA(6), PIK3R1(1), PLCG1(2), PRKCA(1)	5714646	14	14	13	1	4	1	1	4	4	0	0.118	0.0131	0.187
44	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	F13A1(3), F2R(1), FGA(2), FGB(2), FGG(2), PLG(1)	4909993	11	11	11	1	1	2	4	3	1	0	0.211	0.0133	0.187
45	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(2), IFNG(1), JAK1(1), PTPRU(7), STAT1(2)	4237234	13	12	13	2	2	3	3	4	1	0	0.183	0.0187	0.256
46	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(1), GABRA2(2), GABRA4(1), GABRA5(2), GABRA6(2), PRKCE(2)	2956453	10	9	10	1	2	4	1	1	2	0	0.131	0.0209	0.280
47	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	MAPK1(1), PIK3CA(6), PIK3CD(1), PTEN(8), PTK2B(2)	7331988	18	16	17	2	2	2	1	7	6	0	0.226	0.0228	0.299
48	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRB(2), HMOX1(1), IL10RA(2), IL1A(1), JAK1(1), STAT1(2), STAT5A(1), TNF(1)	4484234	11	11	11	0	3	1	3	1	3	0	0.0300	0.0243	0.312
49	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(5), COL4A2(2), COL4A3(6), COL4A4(4), COL4A5(3), COL4A6(4)	9453930	24	19	23	1	0	11	4	3	6	0	0.00559	0.0252	0.317
50	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(1), ALPL(3), ALPP(1), FPGS(1), GGH(1)	2477157	7	7	7	1	1	2	3	0	1	0	0.282	0.0537	0.654
51	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(1), PLCG1(2), PRKCA(1), PTK2B(2)	2400809	6	6	6	0	0	2	0	1	3	0	0.146	0.0541	0.654
52	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	FUT1(3), FUT2(1), FUT9(3)	2247711	7	6	7	1	3	3	0	1	0	0	0.187	0.0609	0.721
53	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARSB(2), PAH(1), TAT(2), YARS(1), YARS2(2)	3195117	8	8	8	0	0	3	2	2	1	0	0.0960	0.0708	0.823
54	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(1), ENO2(2), PAH(1), TAT(2), YARS(1)	2986316	7	7	7	0	1	2	1	1	2	0	0.164	0.0821	0.936
55	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	CISH(2), IL6R(1), JAK1(1), JAK3(2), PTPRU(7)	5706554	13	12	13	2	3	2	4	4	0	0	0.202	0.0873	0.974
56	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	FUT1(3), FUT2(1), FUT5(1)	1879647	5	5	5	0	2	2	1	0	0	0	0.104	0.0895	0.974
57	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	NFKB1(1), PIK3CA(6), PIK3R1(1), RELA(2)	5191370	10	10	9	1	2	2	1	3	2	0	0.196	0.0902	0.974
58	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	23	APC(5), AXIN1(1), BTRC(1), CCND1(1), CREBBP(4), CTBP1(1), DVL1(2), MAP3K7(1), MYC(3), TLE1(1), WIF1(3)	10905200	23	19	23	1	9	5	1	1	7	0	0.00426	0.0933	0.991
59	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(1), LPL(2), RXRA(1), TNF(1)	2106899	5	5	5	1	2	0	2	0	1	0	0.468	0.0963	1.000
60	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	CREBBP(4), EP300(2), FYN(1), IL2RG(1), IL7R(1), JAK1(1), JAK3(2), LCK(1), NMI(1), PIK3CA(6), PIK3R1(1), PTK2B(2), STAT5A(1)	10265659	24	19	23	2	4	4	3	7	6	0	0.0354	0.106	1.000
61	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ARPC1B(1), PAK1(1), PDGFRA(1), PIK3CA(6), PIK3R1(1), RAC1(1)	4956892	11	10	10	0	2	1	2	4	2	0	0.0619	0.112	1.000
62	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(1), PLCB1(4), TUB(3)	2584336	8	7	8	2	1	3	1	3	0	0	0.431	0.112	1.000
63	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	17	CDKN1A(2), NFATC2(1), PLCG1(2), PPP3CC(2), PRKCA(1), SP1(2), SP3(2), SYT1(1)	7316446	13	13	13	1	1	2	3	3	4	0	0.202	0.119	1.000
64	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(2), CYP2E1(2), NR1I3(1), PTGS2(1)	1945899	6	5	6	1	1	0	2	2	1	0	0.451	0.131	1.000
65	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDPS(2), IDI1(1)	1221002	3	3	3	0	0	0	1	0	2	0	0.835	0.133	1.000
66	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(1), BDH2(2), HMGCS1(1), HMGCS2(1), OXCT2(1)	2660992	6	6	6	1	3	0	2	1	0	0	0.415	0.137	1.000
67	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	CBS(1), DNMT1(1), DNMT3A(3), DNMT3B(2), MARS(1), MARS2(1), MTFMT(1), MTR(1), TAT(2)	7691995	13	13	13	1	1	1	3	3	4	1	0.213	0.146	1.000
68	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	NFKB1(1), PLCB1(4), PRKCA(1), RELA(2)	3011889	8	7	8	2	1	4	0	2	1	0	0.410	0.157	1.000
69	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(1), GNAS(2), PRKACA(2)	2434127	5	5	5	1	2	0	0	3	0	0	0.584	0.159	1.000
70	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	FUT1(3), FUT2(1), FUT9(3), GLA(1)	3621632	8	7	8	0	3	3	0	1	1	0	0.0506	0.160	1.000
71	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	12	IGF1(1), IGF1R(1), PIK3CA(6), PIK3R1(1)	4808268	9	9	8	0	1	1	1	4	2	0	0.0943	0.165	1.000
72	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	CDKN1A(2), MAP2K2(1), NGFR(1), NTRK1(3), PIK3CA(6), PIK3CD(1)	6195961	14	13	13	2	7	0	1	4	2	0	0.224	0.165	1.000
73	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(4), FTCD(1), GART(1), MTFMT(1), MTHFD1(1), MTHFD1L(1), MTHFR(1), MTHFS(1), MTR(1)	7017922	12	11	12	1	2	1	5	2	2	0	0.234	0.174	1.000
74	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	TAT(2)	941384	2	2	2	0	0	1	0	0	1	0	0.617	0.178	1.000
75	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA2A(1), ADORA3(2), P2RY2(1), P2RY6(1)	2041614	5	5	5	0	0	1	2	2	0	0	0.217	0.184	1.000
76	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	FUT1(3), FUT2(1), FUT9(3), GLA(1)	3832560	8	7	8	1	3	3	0	1	1	0	0.160	0.185	1.000
77	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(2), ACO1(3), ACSS2(2), IDH1(2)	4847518	9	8	9	1	1	3	1	2	2	0	0.155	0.188	1.000
78	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA1(3), ANXA3(2), ANXA4(1), ANXA6(1), EDNRA(1), HSD11B1(1), PLA2G4A(1), PTGER2(2), PTGIR(1), PTGIS(1), PTGS2(1), SCGB1A1(1), TBXAS1(1)	7529885	17	13	17	1	2	6	2	3	4	0	0.0194	0.194	1.000
79	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG3(1), ATG5(1), BECN1(1), IFNA1(1), IFNA14(1), IFNA16(1), IFNA17(1), IFNA8(1), IFNG(1), PIK3R4(2), PRKAA2(4), ULK1(2), ULK2(2), ULK3(1)	7837138	20	16	20	2	2	10	4	3	1	0	0.0246	0.201	1.000
80	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	EIF4A2(2), EIF4G1(1), EIF4G3(3), IRS1(1), MAPK1(1), PABPC1(2), PIK3CA(6), PIK3R1(1), PRKCA(1), PTEN(8)	10318499	26	21	25	4	2	6	2	9	7	0	0.158	0.201	1.000
81	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	AGT(1), AGTR2(1), EDNRA(1), EGF(4), EGFR(2), MYC(3), NFKB1(1), PLCG1(2), PRKCA(1), RELA(2)	7401387	18	13	18	3	2	7	1	2	6	0	0.0982	0.205	1.000
82	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	35	DOCK1(2), GAB1(1), HGF(1), ITGA1(1), MAP2K2(1), MAP4K1(3), MAPK1(1), MET(4), PAK1(1), PIK3CA(6), PIK3R1(1), PTEN(8), PTK2(3), PTK2B(2), PTPN11(3), RAP1A(1), RASA1(2)	16776175	41	33	40	5	8	8	5	11	9	0	0.0135	0.210	1.000
83	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR2(2), ITPKA(1), PDE1A(2), PDE1B(2), PLCB1(4), PLCB2(1)	4034236	12	9	12	3	4	4	1	2	1	0	0.263	0.213	1.000
84	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	EIF4A2(2), EIF4G1(1), EIF4G3(3), PIK3CA(6), PIK3R1(1), PTEN(8), TSC1(1), TSC2(4)	10251974	26	22	25	4	3	4	1	11	7	0	0.182	0.217	1.000
85	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	42	BRAF(1), CAMP(1), CREBBP(4), EGR1(1), EGR2(1), FRS2(1), MAP1B(5), MAP2K4(2), MAP2K7(2), MAPK1(1), MAPK10(2), MAPK8IP3(2), NTRK1(3), PIK3C2G(7), PIK3CA(6), PIK3CD(1), PIK3R1(1), PTPN11(3), TH(1)	19129765	45	38	44	5	8	10	6	11	10	0	0.00551	0.219	1.000
86	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(3), CHAT(1), PDHA2(2)	2534330	6	6	6	0	3	1	1	0	1	0	0.0754	0.220	1.000
87	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDPS(2), IDI1(1)	1609985	3	3	3	0	0	0	1	0	2	0	0.839	0.232	1.000
88	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH4(2), ADH7(3)	2070772	5	4	5	1	1	1	0	1	2	0	0.568	0.232	1.000
89	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLD1(2), POLE(5), POLG(1), POLQ(6)	6116622	14	11	14	0	1	5	6	1	1	0	0.0135	0.233	1.000
90	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(1), MBTPS1(1), SCAP(4), SREBF1(2), SREBF2(1)	4462487	9	8	9	1	2	2	3	1	1	0	0.166	0.234	1.000
91	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	COASY(1), DPYD(6), ENPP3(2), PANK1(1), PANK3(1), PPCS(1)	5147210	12	10	12	1	0	5	2	2	3	0	0.0707	0.254	1.000
92	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	26	APC(5), AXIN1(1), CCND1(1), DVL1(2), LBP(1), NFKB1(1), PIK3CA(6), PIK3R1(1), RELA(2), TIRAP(1), TLR4(1)	11124226	22	18	21	2	6	4	3	3	6	0	0.0299	0.265	1.000
93	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	EGF(4), EGFR(2), JAK1(1), MAP2K4(2), PIK3CA(6), PIK3R1(1), PLCG1(2), PRKCA(1), RASA1(2), SRF(1), STAT1(2), STAT5A(1)	13794753	25	19	24	3	2	6	3	5	8	1	0.0427	0.271	1.000
94	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	ADCY1(1), ITGAV(3), MAPK1(1), PDGFRA(1), PIK3CA(6), PIK3R1(1), PLCB1(4), PRKCA(1), PTK2(3), RAC1(1), SMPD2(1)	9961839	23	18	22	3	3	3	4	8	5	0	0.0900	0.275	1.000
95	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(2), MPO(4), TPO(1), TYR(2)	3588374	9	8	9	2	0	6	1	0	2	0	0.158	0.294	1.000
96	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	FUT1(3), FUT2(1)	2605915	4	4	4	0	2	2	0	0	0	0	0.162	0.301	1.000
97	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3G(1)	413486	1	1	1	0	0	0	1	0	0	0	0.840	0.306	1.000
98	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	CBS(1), DNMT1(1), DNMT3A(3), DNMT3B(2), MARS(1), MARS2(1), MTR(1)	6495443	10	10	10	1	1	0	2	3	3	1	0.349	0.311	1.000
99	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNA1(1), IFNG(1), IL16(1), IL1A(1), TNF(1)	3603458	5	5	5	0	1	0	1	2	1	0	0.210	0.312	1.000
100	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	RAB27A(1), RAB4A(1), RAB6A(1)	1552071	3	3	3	0	1	1	0	0	1	0	0.332	0.313	1.000
101	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CCL3(1), EPO(1), IGF1(1), IL1A(1), TGFB1(1)	3095050	5	5	5	1	1	1	3	0	0	0	0.457	0.318	1.000
102	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(4), GART(1), MTHFD1(1), MTHFD1L(1), MTHFR(1), MTHFS(1), MTR(1)	6585096	10	9	10	1	2	0	4	2	2	0	0.366	0.325	1.000
103	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	ANXA1(3), GNAS(2), NFKB1(1), NOS3(2), PIK3CA(6), PIK3R1(1), RELA(2), SYT1(1)	6717958	18	18	17	4	4	3	2	5	4	0	0.339	0.328	1.000
104	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	KLRC3(1), PAK1(1), PIK3CA(6), PIK3R1(1), PTK2B(2), RAC1(1), SYK(1), VAV1(3)	6984587	16	15	15	3	3	3	2	5	3	0	0.211	0.333	1.000
105	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP6(1), ENPP3(2), FLAD1(2), LHPP(2), TYR(2)	5531371	9	9	9	2	1	1	5	0	2	0	0.530	0.353	1.000
106	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(1), CCND1(1), CDK4(1), CDKN2A(1), E2F4(2)	3297441	6	5	6	0	1	0	2	2	1	0	0.176	0.354	1.000
107	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	CBS(1), MUT(2)	1799802	3	3	3	1	0	1	0	2	0	0	0.678	0.360	1.000
108	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(2), ENO1(1), PFKL(2), PKLR(2)	3451942	7	6	7	1	3	0	0	1	3	0	0.264	0.362	1.000
109	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	HLA-DRB1(1)	854069	1	1	1	1	1	0	0	0	0	0	0.868	0.372	1.000
110	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	16	ALOX12(2), ALOX15(1), ALOX15B(1), ALOX5(1), DPEP1(2), GGT1(1), PTGIS(1), PTGS2(1), TBXAS1(1)	5850401	11	11	11	2	2	2	4	2	1	0	0.263	0.372	1.000
111	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	CRY1(2), CRY2(1), PER1(3)	3079018	6	6	6	0	0	3	1	2	0	0	0.133	0.375	1.000
112	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	GNS(1), GUSB(2), HPSE2(3), IDUA(2), LCT(4), NAGLU(1), SPAM1(2)	7747223	15	14	15	2	5	3	4	1	2	0	0.0685	0.375	1.000
113	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(2), GABRA1(1), GABRA2(2), GABRA4(1), GABRA5(2), GABRA6(2)	4499992	10	9	10	2	2	4	1	2	1	0	0.255	0.376	1.000
114	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	ADCY1(1), ARHGEF1(1), F2R(1), MAP3K7(1), PIK3CA(6), PIK3R1(1), PLCB1(4), PPP1R12B(1), PRKCA(1), PTK2B(2), ROCK1(1)	9527472	20	18	19	4	2	4	3	6	5	0	0.265	0.382	1.000
115	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD86(1), HLA-DRB1(1), IFNG(1), IL12RB1(1), IL12RB2(3), IL18R1(1)	4646531	8	8	8	2	1	2	2	1	2	0	0.452	0.386	1.000
116	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(1), LPL(2)	1948237	3	3	3	0	1	0	1	1	0	0	0.409	0.397	1.000
117	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	FMOD(2)	1306624	2	2	2	0	1	1	0	0	0	0	0.382	0.402	1.000
118	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	25	MAP2K3(2), MAP2K4(2), MAP2K6(2), NFKB1(1), RELA(2), RIPK1(2), TNF(1), TNFRSF1A(1), TRAF2(2)	9024807	15	15	15	2	3	4	2	4	2	0	0.107	0.403	1.000
119	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(1), DIAPH1(2), FYN(1), ITGA1(1), MAPK1(1), MYLK(3), PIK3CA(6), PIK3R1(1), PTK2(3), ROCK1(1), TLN1(2)	13798973	22	18	21	2	3	2	6	6	5	0	0.0988	0.419	1.000
120	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BAG4(1), RIPK1(2), TNF(1), TNFRSF1A(1), TRAF2(2)	3057882	7	7	7	2	2	2	2	0	1	0	0.556	0.426	1.000
121	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	BCR(2), MAP2K4(2), MYC(3), PIK3CA(6), PIK3R1(1), STAT1(2), STAT5A(1)	10361922	17	16	16	2	3	2	3	4	5	0	0.0946	0.428	1.000
122	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(1), JAK1(1), STAT1(2)	3016983	4	4	4	0	0	1	1	1	1	0	0.300	0.436	1.000
123	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AASDHPPT(1), AASS(1)	1735243	2	2	2	0	0	1	0	0	1	0	0.595	0.438	1.000
124	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	IFNG(1)	1098253	1	1	1	0	0	0	0	1	0	0	0.799	0.446	1.000
125	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	GNS(1), GUSB(2), IDUA(2), LCT(4), NAGLU(1)	5409426	10	10	10	2	3	2	3	1	1	0	0.234	0.447	1.000
126	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	KHK(1), LCT(4), PGM1(1), PYGM(2)	5056127	8	8	8	1	1	4	3	0	0	0	0.133	0.455	1.000
127	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ3(1), NDUFA13(1)	1595328	2	2	2	1	0	1	1	0	0	0	0.813	0.458	1.000
128	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	IFNAR1(1), NFKB1(1), RELA(2), TRAF6(2)	4066113	6	6	6	1	1	2	2	1	0	0	0.386	0.459	1.000
129	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAS1(1), ALAS2(2), PPOX(1)	2780189	4	4	4	0	0	0	3	0	1	0	0.344	0.460	1.000
130	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(1), GAD1(1), HDC(3), TH(1)	2222450	6	6	6	2	2	3	0	1	0	0	0.448	0.468	1.000
131	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	PLCG1(2), PRKCA(1), PTK2B(2), SYT1(1)	5016544	6	6	6	1	0	2	0	1	3	0	0.374	0.472	1.000
132	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(2), TPK1(1)	2310105	3	3	3	0	1	0	1	0	1	0	0.399	0.478	1.000
133	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	DPM2(1), EGR1(1), MAP2K2(1), MAPK1(1), NGFR(1)	3125415	5	5	5	1	2	1	0	1	1	0	0.424	0.491	1.000
134	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(2), EIF2AK4(2), EIF2S2(1)	4196660	5	5	5	0	2	0	2	0	1	0	0.389	0.495	1.000
135	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	CHST11(1), SULT1A1(1), SULT1E1(1), SULT2A1(1), SUOX(1)	3389370	5	5	5	1	1	1	0	2	1	0	0.554	0.495	1.000
136	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RANBP2(3), RANGAP1(2)	3142102	5	4	5	1	1	1	0	2	1	0	0.588	0.498	1.000
137	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(1), BCAR1(1), CTNNA1(2), CTNNA2(5), PTK2(3)	7199282	12	10	12	1	3	3	2	4	0	0	0.0991	0.509	1.000
138	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ENPP3(2), FLAD1(2), TYR(2)	3599910	6	6	6	2	0	1	3	0	2	0	0.717	0.509	1.000
139	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(1), MAP2K2(1), MAP2K3(2), MAP2K4(2), MAPK1(1), PAK1(1), PLCG1(2), PRKCA(1), PTK2B(2), RAC1(1), SYT1(1)	10558749	15	15	15	2	1	3	2	4	5	0	0.155	0.509	1.000
140	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	DPM2(1), NGFR(1), PIK3CA(6), PIK3R1(1), PLCG1(2)	7022078	11	11	10	2	2	1	1	4	3	0	0.328	0.511	1.000
141	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	34	APC(5), AR(4), BRAF(1), CAMP(1), CCL15(1), EGFR(2), GNA11(1), ITPKA(1), ITPR1(4), ITPR2(6), ITPR3(2), KCNJ3(1), KCNJ5(2), MAPK1(1), MAPK10(2), PHKA2(2), PIK3CA(6), PIK3CD(1), PIK3R1(1)	19698978	44	35	42	7	9	9	4	11	11	0	0.0261	0.515	1.000
142	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	SULT1E1(1), SULT2A1(1), SUOX(1)	2162512	3	3	3	0	0	1	0	1	1	0	0.427	0.517	1.000
143	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	22	ADCY1(1), CSF2RB(2), IGF1(1), IGF1R(1), KIT(4), PIK3CA(6), PIK3R1(1), PRKAR2B(1)	8095360	17	14	16	3	3	2	3	5	3	1	0.254	0.522	1.000
144	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	NFKB1(1), NOX1(1), RELA(2), TNF(1)	3683965	5	5	5	1	2	3	0	0	0	0	0.327	0.531	1.000
145	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(3), IDH1(2)	3265368	5	4	5	0	1	2	1	0	1	0	0.152	0.533	1.000
146	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD3G(1), IFNG(1), TGFB1(1), TGFBR1(1), TGFBR2(1), TGFBR3(2)	3822364	7	7	7	2	0	1	3	2	1	0	0.661	0.551	1.000
147	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CSF1R(2), EGF(4), EGFR(2), MET(4), PDGFRA(1), PRKCA(1), SH3GLB1(1), SH3GLB2(1)	7154050	16	10	16	2	2	7	2	2	3	0	0.0606	0.563	1.000
148	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(5), COL4A2(2), COL4A3(6), COL4A4(4), COL4A5(3), COL4A6(4), F11(1), F12(1), F2R(1), F5(5), F8(3), FGA(2), FGB(2), FGG(2), KLKB1(2), PROS1(1)	16302896	44	32	43	9	2	18	8	8	8	0	0.0982	0.568	1.000
149	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ARPC1B(1), NCKAP1(2), NTRK1(3), RAC1(1), WASF3(2)	5674758	9	8	9	1	5	2	0	0	2	0	0.211	0.570	1.000
150	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	CNR1(3), DNMT1(1), MTNR1A(1), PTAFR(1), PTGER2(2), PTGIR(1)	4104026	9	7	9	2	2	0	3	2	2	0	0.422	0.578	1.000
151	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(1), AGT(1), AGTR1(1), AGTR2(1), KNG1(1), NOS3(2), REN(1)	3618924	8	7	8	2	0	1	2	1	4	0	0.634	0.580	1.000
152	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(3), GRHPR(1), MTHFD1(1), MTHFD1L(1)	4665657	6	5	6	1	0	2	2	0	2	0	0.443	0.583	1.000
153	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	GPD2(1), SDHA(1), UQCRC1(1)	2393603	3	3	3	0	1	0	1	1	0	0	0.459	0.584	1.000
154	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	JAK1(1), MAP2K4(2), PDGFRA(1), PIK3CA(6), PIK3R1(1), PLCG1(2), PRKCA(1), RASA1(2), SRF(1), STAT1(2), STAT5A(1)	12892303	20	18	19	3	2	3	2	6	6	1	0.146	0.589	1.000
155	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH4(2), ADH7(3), ALDH1A3(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1)	4906155	10	9	10	3	1	1	3	2	3	0	0.670	0.590	1.000
156	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD3G(1), CD86(1), CTLA4(1), HLA-DRB1(1), LCK(1), PIK3CA(6), PIK3R1(1), PTPN11(3)	4655719	15	13	14	4	3	3	3	4	2	0	0.412	0.594	1.000
157	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	CBS(1), GGT1(1), MARS(1), MARS2(1), SEPHS1(1)	4593312	5	5	5	0	1	0	3	1	0	0	0.278	0.601	1.000
158	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	MST1R(2), TNF(1)	2404936	3	3	3	1	2	0	0	1	0	0	0.649	0.603	1.000
159	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD34(1), CD3G(1), CD58(1)	2305245	3	3	3	0	0	2	1	0	0	0	0.311	0.606	1.000
160	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDOB(2)	1389491	2	2	2	1	1	0	0	0	1	0	0.806	0.615	1.000
161	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	CANX(1), CIITA(3), HLA-DOA(1), HLA-DOB(1), HLA-DQA2(2), HLA-DRB1(1), HLA-DRB5(1), HLA-E(1), HLA-F(1), HSP90AA1(2), HSP90AB1(2), IFNA1(1), IFNA14(1), IFNA16(1), IFNA17(1), IFNA8(1), KIR3DL1(2), KIR3DL2(1), KLRC3(1), LGMN(1)	17185098	26	23	26	3	5	7	7	5	2	0	0.0153	0.623	1.000
162	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	NRF1(1), UBE2C(1), UBE2G2(1), UBE2I(1), UBE2J1(1), UBE3A(1)	3942238	6	6	6	2	0	2	2	1	1	0	0.773	0.625	1.000
163	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAS1(1), ALAS2(2), BLVRB(2), COX10(1), CP(3), EARS2(1), EPRS(1), FTMT(2), GUSB(2), HCCS(1), HMOX1(1), HMOX2(1), PPOX(1), UGT1A10(1), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT2A3(1), UGT2B11(3), UGT2B15(1), UGT2B17(2)	15372800	31	25	31	5	7	5	9	4	6	0	0.122	0.631	1.000
164	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	50	CPT1B(1), CREBBP(4), EP300(2), HSD17B4(1), LPL(2), MAPK1(1), ME1(1), MYC(3), NCOA1(1), NCOR1(1), NCOR2(3), NRIP1(3), PIK3CA(6), PIK3R1(1), PPARA(1), PRKAR2B(1), PRKCA(1), PTGS2(1), RB1(24), RELA(2), RXRA(1), SP1(2), STAT5A(1), TNF(1)	23141515	65	52	64	12	8	8	7	9	31	2	0.0863	0.632	1.000
165	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	PIK3CA(6), PIK3R1(1), PLCG1(2), PRKCA(1), RASA1(2), STAT1(2), STAT5A(1)	10997162	15	14	14	2	2	3	1	4	5	0	0.160	0.635	1.000
166	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QA(1), C1QB(1), C1S(1), C3(4), C5(2), C6(4), C7(1), C8A(1), C9(3), MASP1(3), MASP2(1), MBL2(1)	7954958	23	19	23	5	3	6	5	6	3	0	0.181	0.636	1.000
167	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	AOC3(1), CES1(1)	2218652	2	2	2	1	2	0	0	0	0	0	0.733	0.636	1.000
168	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A2(1), ALDH1A3(2), ALDH2(1), ALDH9A1(1)	2900271	5	5	5	2	0	0	2	2	1	0	0.820	0.637	1.000
169	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A2(1), ALDH1A3(2), ALDH2(1), ALDH9A1(1)	2900271	5	5	5	2	0	0	2	2	1	0	0.820	0.637	1.000
170	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(1), CD33(1), IFNA1(1), IFNG(1), TLR2(3), TLR4(1), TLR9(2)	6694155	10	10	10	2	1	2	2	5	0	0	0.390	0.642	1.000
171	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CAMK2B(1), CAMK2G(1), CAMKK1(2), SYT1(1)	4301453	5	5	5	1	0	1	3	0	1	0	0.453	0.647	1.000
172	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(1), ACAT1(1)	2015575	2	2	2	0	0	0	1	1	0	0	0.646	0.651	1.000
173	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AASDHPPT(1), AASS(1)	2542768	2	2	2	0	0	1	0	0	1	0	0.607	0.653	1.000
174	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CD3G(1)	1153222	1	1	1	0	0	0	1	0	0	0	0.811	0.669	1.000
175	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	PRKCA(1), TGM2(1)	1867407	2	2	2	1	1	0	0	0	1	0	0.844	0.670	1.000
176	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(1), NME2(1), POLD1(2), POLG(1)	4819086	5	5	5	1	0	2	3	0	0	0	0.467	0.684	1.000
177	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(5), EGF(4), EGFR(2), TF(1)	4696072	12	7	12	4	1	5	2	1	3	0	0.474	0.684	1.000
178	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	NR1H4(1), RXRA(1)	1996186	2	2	2	1	0	0	1	0	1	0	0.867	0.687	1.000
179	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(2)	1768149	2	2	2	0	0	2	0	0	0	0	0.406	0.688	1.000
180	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	ANGPTL2(2), ITGA9(1), ITPKA(1), ITPR1(4), ITPR2(6), ITPR3(2), MAPK1(1), NR1I3(1), PAK1(1), PDE3A(1), PDE3B(3), PI3(1), PIK3C2G(7), PIK3CA(6), PIK3CD(1), PIK3R1(1), VASP(1)	18020440	40	33	39	7	7	3	7	14	9	0	0.142	0.699	1.000
181	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	CALCR(3), CALCRL(1), CD97(1), CRHR2(4), ELTD1(3), EMR1(3), EMR2(2), GLP1R(2), GLP2R(2), GPR64(1), LPHN1(1), LPHN2(4), LPHN3(1), SCTR(3), VIPR1(2)	10142506	33	24	33	8	4	7	8	9	5	0	0.184	0.701	1.000
182	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP5O(1), ATP6AP1(2), ATP6V0A4(1), ATP6V1A(2), ATP6V1E1(1), FDXR(1)	5891919	8	7	8	2	1	0	4	2	1	0	0.609	0.701	1.000
183	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAS1(1), ALAS2(2)	3042020	3	3	3	1	0	0	2	0	1	0	0.754	0.704	1.000
184	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	22	IL1A(1), MAP3K7(1), NFKB1(1), RELA(2), RIPK1(2), TLR4(1), TNF(1), TNFRSF1A(1), TRAF6(2)	8984814	12	12	12	2	3	4	4	1	0	0	0.225	0.708	1.000
185	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(1), AGT(1), AGTR1(1), AGTR2(1), ANPEP(1), CTSG(1), LNPEP(2), MME(2), REN(1)	7677413	11	10	11	2	2	1	2	3	3	0	0.468	0.709	1.000
186	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3G(1), FYN(1), HLA-DRB1(1), LCK(1), PTPRC(4), ZAP70(5)	3349671	13	11	13	4	4	5	3	1	0	0	0.332	0.714	1.000
187	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	EPX(2), MPO(4), MTHFR(1), TPO(1)	4251294	8	7	8	2	0	5	1	0	2	0	0.202	0.716	1.000
188	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	B3GNT2(2), FUT1(3), FUT2(1), FUT5(1), FUT9(3)	5775991	10	9	10	2	3	5	1	1	0	0	0.194	0.721	1.000
189	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD3G(1), ITGB2(1), PTPRC(4)	3866326	6	6	6	2	2	1	3	0	0	0	0.611	0.722	1.000
190	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A2(1)	1398279	1	1	1	0	0	0	0	1	0	0	0.795	0.725	1.000
191	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(1), LDHB(1)	2492161	2	2	2	0	0	0	0	1	1	0	0.795	0.728	1.000
192	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	IFNG(1), IL1A(1), NR4A3(1)	3983156	3	3	3	1	1	0	1	1	0	0	0.709	0.731	1.000
193	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT2(2), CHST1(2), CHST4(1), FUT8(1)	4385616	6	5	6	0	0	4	2	0	0	0	0.0570	0.734	1.000
194	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB11(2), ABCB4(3), ABCC1(1), ABCC3(5)	5341135	11	10	11	3	2	3	2	2	2	0	0.366	0.734	1.000
195	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	FOSB(1)	1380104	1	1	1	0	0	0	0	0	1	0	1.000	0.736	1.000
196	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	IFNG(1), MAP3K5(4), MAP4K5(1), NFKB1(1), RELA(2), TNFRSF9(2), TRAF2(2)	7299353	13	12	13	3	2	4	1	3	3	0	0.333	0.737	1.000
197	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(1), ALDH18A1(1), ARG2(2), CPS1(1), PYCR1(2)	6614628	7	7	7	0	2	2	1	0	2	0	0.0917	0.737	1.000
198	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(1)	1264626	1	1	1	0	0	0	0	1	0	0	0.738	0.738	1.000
199	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(2), GBA(1), MPO(4), TPO(1)	3111935	8	7	8	3	0	5	0	1	2	0	0.346	0.741	1.000
200	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	MMP9(1), TIMP1(1), TIMP2(1)	2861972	3	3	3	0	0	1	1	1	0	0	0.401	0.748	1.000
201	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	MAP2K4(2), MAP2K6(2), MAP3K5(4), MAP3K7(1), MAP3K9(2), MEF2B(2), MEF2C(1), MYC(3), PLA2G4A(1), RAC1(1), RIPK1(2), STAT1(2), TGFB1(1), TGFBR1(1), TRAF2(2)	13803413	27	19	27	3	4	9	4	5	5	0	0.0223	0.750	1.000
202	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD3G(1), ITGB2(1), PTPRC(4)	4070928	6	6	6	2	2	1	3	0	0	0	0.615	0.750	1.000
203	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CREBBP(4), EP300(2), MAP2K3(2), MAP2K6(2), MAP3K7(1), MAPK11(1), NFKB1(1), RELA(2), TGFBR1(1), TGFBR2(1), TLR2(3), TNF(1)	10729764	21	18	21	4	4	4	3	7	3	0	0.247	0.757	1.000
204	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	CREBBP(4), SET(1)	3854883	5	4	5	1	1	2	0	0	2	0	0.533	0.760	1.000
205	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(1), AGTR1(1), EGFR(2), MAP2K2(1), MAP2K4(2), MAPK1(1), MEF2B(2), MEF2C(1), PAK1(1), PRKCA(1), PTK2(3), PTK2B(2), RAC1(1), SYT1(1)	12715173	20	16	20	3	2	5	3	2	8	0	0.122	0.761	1.000
206	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(2), ME1(1)	3440072	3	3	3	1	1	1	0	1	0	0	0.695	0.765	1.000
207	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	CRY1(2), CRY2(1), PER1(3), PER2(1), PER3(3)	6125878	10	7	10	1	2	5	1	2	0	0	0.115	0.765	1.000
208	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(1), CPT1A(1), PRKAA2(4), PRKAB2(1)	5307054	7	5	7	1	0	3	3	1	0	0	0.358	0.767	1.000
209	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(1), GNAS(2), PRKAR2B(1), PRKCA(1)	3604470	5	5	5	3	1	0	0	1	3	0	0.957	0.767	1.000
210	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(5), CREBBP(4), EP300(2), MAP3K7(1), SKIL(2), TGFB1(1), TGFBR1(1), TGFBR2(1)	9174057	17	15	17	4	2	3	4	2	6	0	0.506	0.768	1.000
211	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	16	CREBBP(4), EP300(2), HDAC3(1), NFKB1(1), RELA(2), RIPK1(2), TNF(1), TNFRSF1A(1), TRAF6(2)	8140100	16	14	16	3	4	5	1	4	2	0	0.232	0.771	1.000
212	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(1), ATP6AP1(2), ATP6V0A4(1), ATP6V1A(2), ATP6V1E1(1)	5561173	7	6	7	2	1	0	4	1	1	0	0.670	0.774	1.000
213	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(1), ATP6AP1(2), ATP6V0A4(1), ATP6V1A(2), ATP6V1E1(1)	5561173	7	6	7	2	1	0	4	1	1	0	0.670	0.774	1.000
214	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(1), ATP6AP1(2), ATP6V0A4(1), ATP6V1A(2), ATP6V1E1(1)	5561173	7	6	7	2	1	0	4	1	1	0	0.670	0.774	1.000
215	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ALDH1A3(2), AOC3(1), DDC(2), EPX(2), HPD(1), MAOB(1), MPO(4), TAT(2), TPO(1)	8217199	16	14	16	4	4	7	2	0	3	0	0.135	0.774	1.000
216	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(5), AXIN1(1), CREBBP(4), DVL1(2), EP300(2), TRRAP(3)	11889510	17	14	17	2	5	3	0	3	6	0	0.0855	0.780	1.000
217	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	IARS(1), PDHA2(2), PDHB(1)	3657057	4	4	4	0	0	2	1	1	0	0	0.304	0.782	1.000
218	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	ASNS(1), CA12(1), CA2(2), CA3(1), CA4(1), CA9(1), CPS1(1), GLUL(1)	6946521	9	9	9	2	3	2	3	0	1	0	0.375	0.784	1.000
219	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	CAPN1(1), CAPNS1(1), MAPT(1)	3538009	3	3	3	1	1	0	1	0	1	0	0.815	0.790	1.000
220	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS2(2), CARS(1), CARS2(1), DARS(1), EARS2(1), EPRS(1), FARSB(2), HARS2(1), IARS(1), IARS2(1), MARS(1), MARS2(1), MTFMT(1), QARS(1), RARS(2), SARS(2), TARS(1), TARS2(2), WARS(1), WARS2(1), YARS(1), YARS2(2)	19809038	28	26	28	4	3	4	11	9	1	0	0.0901	0.792	1.000
221	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTN1(1), CAPN1(1), CAPNS1(1), ITGA1(1), PTK2(3), RAC1(1), SPTAN1(3), TLN1(2)	10543511	13	11	13	1	3	1	2	2	5	0	0.260	0.793	1.000
222	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	SEC61A2(1), SRP68(1)	2759453	2	2	2	1	0	0	0	2	0	0	0.873	0.794	1.000
223	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMB3(1), PSMB6(1), PSMB9(1)	3208745	3	3	3	1	0	1	2	0	0	0	0.805	0.796	1.000
224	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(2), MAP2(3), PRKAR2B(1), PRKCE(2)	6362099	8	7	8	3	0	3	0	0	4	1	0.793	0.800	1.000
225	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ERBB4(4), NRG2(1), NRG3(1), PRKCA(1)	3367818	7	6	7	5	2	1	1	1	2	0	0.979	0.801	1.000
226	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(3), GRHPR(1), MTHFD1(1), MTHFD1L(1)	4903597	6	5	6	2	0	2	2	0	2	0	0.645	0.804	1.000
227	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	FAS(1), IL1A(1), TNF(1)	4066954	3	3	3	0	1	0	1	0	1	0	0.552	0.814	1.000
228	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	BFAR(2), BRAF(1), CAMP(1), MAPK1(1)	4278790	5	4	5	1	0	3	0	1	1	0	0.475	0.815	1.000
229	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(1), CARS2(1), LDHB(1), SULT1B1(2), SULT1C2(1), SULT4A1(1)	4679360	7	6	7	2	2	1	1	2	1	0	0.588	0.817	1.000
230	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	CAMP(1), ITPKA(1)	2108870	2	2	2	0	1	1	0	0	0	0	0.405	0.817	1.000
231	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMB3(1), PSMB6(1), PSMC3(1), RPN2(2), UBE3A(1)	4882829	6	6	6	0	0	3	1	1	1	0	0.182	0.823	1.000
232	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT1(1), ACOT11(2), DHRS2(1), DHRSX(1), ESCO2(1), FN3K(1), PNPLA3(1), SH3GLB1(1), YOD1(1)	9210733	10	10	10	1	2	3	2	2	1	0	0.150	0.826	1.000
233	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	TGDS(1), UGDH(1), UGP2(1)	1849489	3	2	3	1	0	2	0	0	1	0	0.572	0.826	1.000
234	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	HSD17B4(1), MECR(1)	3164522	2	2	2	0	0	1	0	0	1	0	0.554	0.828	1.000
235	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	NFKB1(1), RELA(2), TRAF2(2), TRAF6(2)	5400720	7	7	7	2	1	2	2	1	1	0	0.601	0.832	1.000
236	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP6(1), ALPI(1), ALPL(3), ALPP(1), CYP3A4(2), CYP3A7(1), DHRS2(1), DHRSX(1)	6603650	11	11	11	3	1	4	4	0	2	0	0.381	0.834	1.000
237	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	ST3GAL5(1)	1978331	1	1	1	1	0	0	0	1	0	0	0.935	0.834	1.000
238	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GGT1(1)	1628554	1	1	1	0	0	0	1	0	0	0	0.786	0.835	1.000
239	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	EPX(2), MPO(4), TPO(1)	4391131	7	6	7	2	0	5	0	0	2	0	0.249	0.837	1.000
240	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	APC(5), AXIN1(1), BTRC(1), DVL1(2), NOTCH1(1)	8037217	10	8	10	2	4	2	0	0	3	1	0.246	0.837	1.000
241	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QA(1), C1QB(1), C1S(1), C3(4), C5(2), C6(4), C7(1), C8A(1), C8B(1), C9(3), MASP1(3)	7731275	22	18	22	6	3	6	4	6	3	0	0.300	0.838	1.000
242	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	TGDS(1), UGDH(1)	1476261	2	1	2	1	0	1	0	0	1	0	0.717	0.839	1.000
243	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(5), CAMP(1), CERK(1), EPHB2(1), ITPKA(1), MAP2K4(2), MAP2K7(2), MAPK1(1), MAPK10(2), MAPK8IP3(2)	10298103	18	16	18	4	6	5	0	2	5	0	0.158	0.842	1.000
244	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	CARS(1), DARS(1), EPRS(1), IARS(1), MARS(1), MARS2(1), QARS(1), RARS(2), SARS(2), TARS(1), WARS(1), WARS2(1), YARS(1)	11623056	15	15	15	3	2	2	4	7	0	0	0.328	0.846	1.000
245	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(1), ARHGEF1(1), MYLK(3), PLCB1(4), PPP1R12B(1), PRKCA(1), ROCK1(1)	7647869	12	9	12	3	1	3	2	4	2	0	0.484	0.849	1.000
246	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	APOBEC3B(2), APOBEC3F(1), APOBEC3G(1)	2694752	4	2	4	2	0	1	1	0	2	0	0.642	0.854	1.000
247	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25B(1), CDKN1A(2), NEK1(2)	2828278	5	4	5	2	2	1	0	1	1	0	0.707	0.854	1.000
248	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(1), FCGR3A(2), IL6R(1), SELL(1), SPN(1), TGFB1(1), TNF(1), TNFRSF1A(1), TNFRSF8(1)	5113478	10	10	10	3	3	2	2	3	0	0	0.449	0.859	1.000
249	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(1), ACACB(2), FASN(3), OXSM(1)	6052197	7	7	7	2	1	0	3	2	1	0	0.586	0.859	1.000
250	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), UGDH(1)	3135641	6	5	6	3	0	1	3	1	1	0	0.832	0.865	1.000
251	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AP2A1(2), AP2M1(2), BTK(1), EEA1(5), LYN(1), PFKL(2), PFKP(1), PLCG1(2), PRKCE(2), RAC1(1), VAV2(3)	9400239	22	15	22	7	1	8	3	2	8	0	0.290	0.866	1.000
252	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMB3(1), PSMB6(1), PSMC2(2), PSMC3(1), PSMD1(1)	5885228	6	5	6	0	0	2	2	1	1	0	0.200	0.867	1.000
253	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(1)	1777909	1	1	1	1	0	0	1	0	0	0	0.916	0.868	1.000
254	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT10(1), GALNT3(1), GALNT7(1), GALNT8(2), WBSCR17(2)	5421077	7	6	7	1	1	4	2	0	0	0	0.190	0.869	1.000
255	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	ASRGL1(1), GBA(1), GGT1(1)	2139803	3	3	3	2	0	1	1	1	0	0	0.837	0.870	1.000
256	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(1), AKR1D1(2), CYP11B1(3), CYP11B2(1), CYP21A2(1), HSD11B1(1), HSD3B1(1)	3644443	10	8	10	8	2	1	1	3	3	0	0.975	0.875	1.000
257	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(1), AKR1D1(2), CYP11B1(3), CYP11B2(1), CYP21A2(1), HSD11B1(1), HSD3B1(1)	3644443	10	8	10	8	2	1	1	3	3	0	0.975	0.875	1.000
258	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	MAPK1(1), PRKCA(1)	3484290	2	2	2	2	0	0	0	0	2	0	1.000	0.879	1.000
259	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A2(1), ALDH1A3(2), ALDH2(1), ALDH9A1(1)	4441886	5	5	5	2	0	0	2	2	1	0	0.822	0.879	1.000
260	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	NFKB1(1), PIK3CA(6), PIK3R1(1), RAC1(1), RELA(2)	7287255	11	11	10	3	2	3	1	3	2	0	0.400	0.882	1.000
261	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	FYN(1), THBS1(1)	2659019	2	2	2	1	0	1	0	1	0	0	0.774	0.882	1.000
262	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(4), EP300(2), MAPK1(1)	5286334	7	6	7	2	1	1	0	2	3	0	0.749	0.885	1.000
263	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	IGF1(1), IGF1R(1), IRS1(1), PIK3CA(6), PIK3R1(1), PTPN11(3), RASA1(2), SRF(1)	9117030	16	13	15	4	2	4	2	5	2	1	0.355	0.888	1.000
264	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	MAP2K2(1), MAP2K3(2), MAP2K6(2), MAPK1(1), NFATC2(1), NFKB1(1), PAK1(1), PIK3C2G(7), PLCB1(4), PPP3CC(2), RAC1(1), RELA(2), SYT1(1)	14318033	26	23	26	5	2	7	6	7	4	0	0.182	0.889	1.000
265	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD9(1), ADH4(2), ADH7(3), DHRS2(1), DHRSX(1), ESCO2(1), PNPLA3(1), SH3GLB1(1)	8803560	11	8	11	2	1	4	2	1	3	0	0.318	0.892	1.000
266	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	PTK2B(2)	3182033	2	2	2	0	0	1	0	0	1	0	0.443	0.892	1.000
267	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CAMK2B(1), CAMK2G(1), ESRRA(1), HDAC5(1), MEF2B(2), MEF2C(1), PPARA(1), PPP3CC(2), SLC2A4(1), SYT1(1)	7673172	12	10	12	3	1	4	3	0	4	0	0.370	0.893	1.000
268	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	EIF2B3(1), EIF2S2(1), FLT1(1), FLT4(2), KDR(4), NOS3(2), PIK3CA(6), PIK3R1(1), PLCG1(2), PRKCA(1), PTK2(3)	12649913	24	23	23	5	3	2	4	10	5	0	0.324	0.895	1.000
269	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(4), EGFR(2)	3762116	6	3	6	3	0	3	1	0	2	0	0.737	0.900	1.000
270	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(2), PARK2(1), SNCAIP(1), UBE2G2(1)	2316896	5	5	5	3	1	2	1	0	1	0	0.880	0.902	1.000
271	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(2), MAPK1(1), MYC(3), NFKB1(1), PLCB1(4), PRKCA(1), RELA(2), TNF(1)	5642121	15	12	15	5	3	6	1	2	3	0	0.435	0.905	1.000
272	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	CPS1(1)	2838312	1	1	1	0	0	0	1	0	0	0	0.840	0.907	1.000
273	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	CCND1(1), CREBBP(4), EP300(2), GRIP1(2), HDAC3(1), HDAC5(1), HDAC6(2), MEF2C(1), NCOR2(3), NR0B1(2), NRIP1(3)	17251677	22	19	22	3	3	5	5	6	3	0	0.104	0.907	1.000
274	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	IGF1R(1), IRS1(1), MAPK1(1), PIK3CA(6), PIK3R1(1)	6919633	10	10	9	3	1	0	2	4	3	0	0.663	0.910	1.000
275	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	DHCR7(1), FDPS(2), HMGCS1(1), IDI1(1)	4939306	5	5	5	2	0	0	3	0	2	0	0.898	0.911	1.000
276	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS2(1), DHRSX(1), ESCO2(1), PNPLA3(1), SH3GLB1(1)	5676066	5	5	5	1	0	2	2	0	1	0	0.512	0.912	1.000
277	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(4), C5(2), C6(4), C7(1), C8A(1), C9(3)	4689168	15	13	15	5	1	2	4	6	2	0	0.586	0.913	1.000
278	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QA(1), C1QB(1), C1S(1), C3(4), C5(2), C6(4), C7(1), C8A(1), C9(3)	6542114	18	16	18	5	2	4	4	6	2	0	0.365	0.913	1.000
279	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	INPP1(1), INPP4B(1), INPP5A(1), INPPL1(1), ITPKA(1), PIK3C2G(7), PIK3CA(6), PIK3CB(1), PIK3CG(2), PLCB1(4), PLCB2(1), PLCB3(1), PLCB4(3), PLCG1(2)	16649135	32	28	31	7	5	7	4	11	5	0	0.205	0.914	1.000
280	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	MAP2K4(2), MAPK1(1), NFKB1(1), NSMAF(1), RELA(2), RIPK1(2), TNFRSF1A(1), TRAF2(2)	7439773	12	12	12	4	2	4	1	1	4	0	0.520	0.915	1.000
281	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	HSD17B4(1), SIRT1(1), SIRT7(1)	4374317	3	3	3	1	0	0	0	1	2	0	0.721	0.916	1.000
282	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSE(1), GAL3ST1(1), GALC(2), GBA(1), GLA(1), LCT(4), NEU3(2), PPAP2A(1), PPAP2C(1), SMPD2(1), SPTLC1(1)	8852858	16	14	15	8	2	2	2	2	8	0	0.888	0.918	1.000
283	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	33	GTF2A1L(1), GTF2B(1), GTF2H1(1), STON1(2), TAF1(3), TAF10(1), TAF1L(9), TAF2(1), TAF6(1), TAF6L(3), TBPL1(1), TBPL2(1)	13276225	25	16	25	4	7	5	6	3	4	0	0.0818	0.919	1.000
284	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR2(2), GPR34(1)	3408833	3	2	3	2	0	0	0	1	2	0	0.872	0.921	1.000
285	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	ACHE(3), CHAT(1), DBH(1), DDC(2), GAD1(1), GAD2(2), HDC(3), PAH(1), TH(1)	5366193	15	13	15	5	7	4	0	3	1	0	0.305	0.923	1.000
286	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	CD3G(1), ITGB2(1)	3162937	2	2	2	1	1	0	1	0	0	0	0.837	0.924	1.000
287	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(1), ALPL(3), ALPP(1), ASCC3(2), ATP13A2(1), DDX18(2), DDX4(1), DDX41(1), DDX50(1), DDX51(1), DDX52(1), DDX56(1), EP400(2), FPGS(1), GGH(1), IFIH1(1), MOV10L1(1), QDPR(2), RAD54B(1), RAD54L(1), RUVBL2(2), SETX(3), SMARCA2(2), SMARCA5(2)	23285243	35	28	35	6	5	10	9	4	7	0	0.0576	0.930	1.000
288	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	CDKN1A(2), EPO(1), GRIN1(2), NFKB1(1), RELA(2)	4715092	8	8	8	3	2	3	1	2	0	0	0.571	0.930	1.000
289	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	DHRS2(1), DHRSX(1), HEMK1(1), PRMT2(2), PRMT3(1), PRMT6(1), PRMT8(1), WBSCR22(1)	5462967	9	7	9	3	1	4	1	2	1	0	0.648	0.933	1.000
290	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	EPO(1)	2297874	1	1	1	0	0	0	1	0	0	0	0.803	0.934	1.000
291	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	BAG4(1), LMNB1(1), MAP2K7(2), MAP3K5(4), MDM2(1), NFKB1(1), PRKDC(5), PSEN2(1), PTK2(3), RASA1(2), RB1(24), RELA(2), RIPK1(2), SPTAN1(3), TNF(1), TNFRSF1A(1), TRAF2(2)	25670274	56	47	56	10	5	12	6	3	28	2	0.0491	0.935	1.000
292	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	EGF(4), EGFR(2), MAPK1(1), PTPRB(4), RASA1(2), SPRY3(2)	9220131	15	10	15	4	1	7	2	1	4	0	0.275	0.941	1.000
293	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(2), ALDH1A3(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), CYP2C19(2), CYP2C9(2), DHRS2(1), DHRSX(1), ESCO2(1), PNPLA3(1), SH3GLB1(1), YOD1(1)	10997634	17	16	17	4	2	4	7	2	2	0	0.354	0.942	1.000
294	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	ATM(5), CDK4(1), DAZL(1), EGR1(1), ESR2(2), GJA4(1), INHA(1), LHCGR(5), MLH1(1), NCOR1(1), NRIP1(3), PRLR(4), PTGER2(2)	12606380	28	22	27	7	1	7	7	6	7	0	0.469	0.943	1.000
295	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(4), EGFR(2), NCOR2(3), RARA(1), RXRA(1), THRA(1)	6512941	12	8	12	4	1	5	2	1	3	0	0.435	0.943	1.000
296	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	MAPK1(1), MAPK7(1), MEF2B(2), MEF2C(1), NTRK1(3), PIK3CA(6), PIK3R1(1), PLCG1(2), RPS6KA1(1)	7227556	18	14	17	5	5	3	1	4	5	0	0.369	0.944	1.000
297	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	B4GALT5(2), FUT8(1), MAN1A1(3), MAN1B1(1), MGAT3(1), RPN2(2)	7236033	10	6	10	1	2	4	1	1	2	0	0.0926	0.945	1.000
298	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	33	MAP2K4(2), MAP2K7(2), MAPK1(1), MAPK10(2), MAPK11(1), MAPK8IP3(2), NFKB1(1), NFKBIL1(1), PIK3CA(6), PIK3CD(1), PIK3R1(1), SYT1(1), TRAF2(2), TRAF6(2)	12825279	25	21	24	6	4	6	3	6	6	0	0.229	0.947	1.000
299	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	EPHA4(2), EPHB1(2), FYN(1), ITGA1(1), L1CAM(1), LYN(1), SELP(2)	5712243	10	9	10	4	2	3	1	3	1	0	0.660	0.951	1.000
300	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	DAB1(2), FYN(1), LRP8(1), RELN(6)	5077091	10	8	10	4	2	3	0	2	3	0	0.577	0.952	1.000
301	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(1), FDPS(2), IDI1(1)	4142364	4	4	4	2	0	0	2	0	2	0	0.933	0.953	1.000
302	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLD1(2), POLE(5), POLG(1), POLQ(6), PRIM2(1), REV1(1), REV3L(2)	15199092	18	14	18	2	1	6	7	1	3	0	0.164	0.954	1.000
303	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	F13B(1), HSD17B1(1), HSD17B2(1), HSD17B4(1), HSD3B1(1)	2925473	5	5	5	4	1	0	0	3	1	0	0.941	0.954	1.000
304	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(2), CYP11B2(1), HSD11B1(1), HSD3B1(1)	2510238	5	4	5	6	1	2	0	1	1	0	0.963	0.955	1.000
305	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(1), ACSL3(1), ACSL4(2), CPT1A(1), SLC25A20(1)	6147583	6	6	6	2	1	1	2	2	0	0	0.683	0.956	1.000
306	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(3), IDH1(2), IDH3A(1), IDH3B(1), IDH3G(1), SDHA(1)	7574163	9	7	9	2	2	3	3	0	1	0	0.285	0.958	1.000
307	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ADH4(2), ADH7(3), AKR1C4(1), AKR1D1(2), ALDH1A2(1), ALDH1A3(2), ALDH2(1), ALDH9A1(1), CEL(3), CYP27A1(1), SOAT2(1)	8569961	18	14	18	5	2	3	3	6	4	0	0.495	0.958	1.000
308	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ARPC1B(1), RAC1(1)	3018007	2	2	2	0	1	1	0	0	0	0	0.449	0.958	1.000
309	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	COASY(1), DPYD(6), ENPP3(2), ILVBL(1), PANK1(1), PANK3(1), PPCS(1)	6457368	13	11	13	4	0	5	3	2	3	0	0.391	0.960	1.000
310	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(4), EP300(2), LPL(2), NCOA1(1), RXRA(1)	6619577	10	8	10	3	2	1	2	3	2	0	0.735	0.960	1.000
311	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CDC25B(1), PRKCA(1), PTPRA(1)	3424273	3	3	3	4	0	2	0	0	1	0	0.980	0.962	1.000
312	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	HLA-DRB1(1), IFNA1(1), IFNG(1), IL1A(1), TGFB1(1), TNF(1)	4970754	6	6	6	3	2	0	2	2	0	0	0.747	0.963	1.000
313	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	HEMK1(1), PRMT2(2), PRMT3(1), PRMT6(1), PRMT8(1), WBSCR22(1)	5190245	7	5	7	3	1	3	0	2	1	0	0.804	0.963	1.000
314	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(1)	2894151	1	1	1	0	0	0	0	1	0	0	0.774	0.964	1.000
315	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	31	ANPEP(1), GCLC(1), GGT1(1), GPX5(2), GSTA4(1), GSTM5(1), IDH1(2)	6829647	9	8	9	3	2	1	3	0	3	0	0.745	0.966	1.000
316	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(1), ACACA(1), ACADL(1), ACADSB(1), ACAT1(1), ALDH1A2(1), ALDH1A3(2), ALDH2(1), ALDH9A1(1), LDHB(1), MUT(2)	12096851	13	13	13	3	0	1	4	5	3	0	0.581	0.969	1.000
317	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(2), CAPNS1(1), EP300(2), NFATC2(1), PPP3CC(2), PRKCA(1), SYT1(1)	8786511	10	10	10	3	0	1	2	3	4	0	0.815	0.969	1.000
318	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAT1(1)	3099511	1	1	1	0	0	0	0	1	0	0	0.754	0.969	1.000
319	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	MEF2B(2), MEF2C(1)	3144047	3	2	3	2	1	1	0	0	1	0	0.853	0.970	1.000
320	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	EGR2(1), MYC(3), NFATC2(1), NFKB1(1), PLCG1(2), PPP3CC(2), PRKAR2B(1), RELA(2), SYT1(1)	9997608	14	13	14	4	2	4	2	2	4	0	0.534	0.970	1.000
321	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	IL6R(1), JAK1(1), JAK3(2), PTPN11(3), SRF(1)	8910453	8	7	8	2	2	1	2	2	0	1	0.521	0.970	1.000
322	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	APC(5), AXIN1(1), BMP5(1), BMPR2(1), CHRD(2), DVL1(2), GATA4(1), MAP3K7(1), MEF2C(1), NKX2-5(1), TGFB1(1), TGFBR1(1), TGFBR2(1), TGFBR3(2)	13214897	21	16	21	4	3	4	4	3	7	0	0.290	0.971	1.000
323	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F2R(1), F5(5), F7(1), FGA(2), FGB(2), FGG(2), PROS1(1), TFPI(1)	6023711	15	15	15	5	1	4	4	4	2	0	0.587	0.971	1.000
324	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	CD3G(1), FYN(1), LCK(1), MAP2K4(2), NFATC2(1), NFKB1(1), PIK3CA(6), PIK3R1(1), PLCG1(2), PPP3CC(2), PRKCA(1), PTPN7(1), RAC1(1), RASA1(2), RELA(2), SYT1(1), VAV1(3), ZAP70(5)	17506582	34	27	33	6	5	10	4	8	7	0	0.0587	0.971	1.000
325	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ADH4(2), ADH7(3), ALDH1A3(2), AOC3(1), AOX1(2), DBH(1), DCT(2), DDC(2), HPD(1), MAOB(1), TAT(2), TH(1), TPO(1), TYR(2)	11791871	23	17	23	6	5	9	4	2	3	0	0.214	0.973	1.000
326	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	IL2RG(1), IRS1(1), JAK1(1), JAK3(2)	5484854	5	5	5	2	1	0	3	1	0	0	0.720	0.973	1.000
327	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	CES1(1)	4144999	1	1	1	1	1	0	0	0	0	0	0.904	0.974	1.000
328	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	CBS(1), GGT1(1), HEMK1(1), MARS(1), MARS2(1), PRMT2(2), PRMT3(1), PRMT6(1), PRMT8(1), SEPHS1(1), WBSCR22(1)	9279862	12	10	12	4	2	3	3	3	1	0	0.645	0.974	1.000
329	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(1), LDHB(1)	3341850	2	2	2	3	1	0	0	0	1	0	0.993	0.974	1.000
330	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	SCAP(4), SREBF1(2), SREBF2(1)	6712979	7	6	7	2	1	2	2	1	1	0	0.517	0.974	1.000
331	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	SNAP29(1), STX16(2), STX7(1), TSNARE1(1), VAMP7(1), YKT6(2)	6291693	8	5	8	2	2	2	2	0	1	1	0.472	0.974	1.000
332	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	16	B3GAT1(2), CHPF(1), CHST11(1), CHST14(1), CHST3(1), DSE(2), XYLT2(2)	5232376	10	7	10	4	2	6	0	1	1	0	0.391	0.975	1.000
333	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	28	BAG4(1), MAP2K4(2), MAP3K7(1), NFKB1(1), NFKBIL1(1), RIPK1(2), TNF(1), TNFRSF1A(1), TRAF2(2)	10333966	12	12	12	3	2	4	3	1	2	0	0.368	0.976	1.000
334	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	AKR1B10(1), DHRS2(1), DHRSX(1)	3245129	3	3	3	2	0	1	2	0	0	0	0.819	0.976	1.000
335	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(1), JUNB(1), MAP2K3(2), NFATC2(1), PRKAR2B(1)	4424361	6	6	6	3	0	0	3	1	2	0	0.912	0.976	1.000
336	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	BLVRB(2), CP(3), EPRS(1), GUSB(2), HCCS(1), HMOX1(1), HMOX2(1), PPOX(1), UGT1A10(1), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT2B15(1)	9972389	18	16	18	5	5	3	3	2	5	0	0.560	0.976	1.000
337	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	ASNS(1), ASRGL1(1), CA12(1), CA2(2), CA3(1), CA4(1), CA9(1), CPS1(1), GLUL(1)	7743058	10	10	10	3	3	3	3	0	1	0	0.462	0.977	1.000
338	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	43	EGF(4), EGFR(2), MAP2K3(2), MAP2K4(2), MAP2K6(2), MAP2K7(2), MAP3K5(4), MAPK1(1), NFKB1(1), PRKCA(1), PRKCE(2), PRKCG(1), PRKCH(1), PRKCQ(2), RELA(2), RIPK1(2), SP1(2), TNF(1), TNFRSF1A(1), TRAF2(2)	18009646	37	26	37	9	5	14	4	5	9	0	0.104	0.978	1.000
339	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	NOTCH1(1)	3725415	1	1	1	2	0	0	0	0	0	1	0.987	0.980	1.000
340	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	DIAPH2(3), MCM10(3), MCM3(1), MCM4(1), MCM5(1), MCM7(1), NACA(2), POLD1(2), POLE(5), RPA1(1), RPA4(1), UBB(2)	18445356	23	19	23	3	3	7	7	2	4	0	0.0576	0.980	1.000
341	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	CAPN1(1), CAPNS1(1), EGF(4), EGFR(2), ITGA1(1), MAPK1(1), MYLK(3), PRKAR2B(1), PTK2(3), TLN1(2)	12183583	19	14	19	5	3	3	5	1	7	0	0.493	0.981	1.000
342	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(1), PRKAR2B(1)	3625301	2	2	2	2	0	0	0	1	1	0	0.979	0.981	1.000
343	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(1), ACAT1(1), ALDH1A2(1), ALDH1A3(2), ALDH2(1), ALDH9A1(1), DLAT(1), GRHPR(1), LDHB(1), ME1(1), ME3(1), PDHA2(2), PDHB(1), PKLR(2)	13551492	17	14	17	3	2	3	5	4	3	0	0.241	0.983	1.000
344	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B4GALT5(2), FUT8(1)	2840489	3	1	3	0	1	2	0	0	0	0	0.238	0.983	1.000
345	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AASDHPPT(1), AASS(1), ACAT1(1), ALDH1A2(1), ALDH1A3(2), ALDH2(1), ALDH9A1(1), BBOX1(2), EHMT2(1), PLOD2(2), PLOD3(1), TMLHE(1)	13605369	15	15	15	4	1	2	3	6	3	0	0.511	0.983	1.000
346	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	GLI2(1), GLI3(1), PRKAR2B(1), SUFU(2)	6043791	5	5	5	2	0	1	0	1	3	0	0.791	0.984	1.000
347	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(2), ACTB(1), ARHGEF2(1), CLDN1(1), CTTN(3), EZR(1), FYN(1), HCLS1(2), KRT18(1), NCK2(1), OCLN(1), PRKCA(1), ROCK1(1), ROCK2(1), TLR4(1), TLR5(2), TUBA3C(3), TUBA3E(1), TUBA4A(1), TUBA8(1), TUBAL3(2), TUBB2B(2), TUBB8(3)	19343457	34	29	33	9	5	7	7	9	6	0	0.330	0.984	1.000
348	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(2), ACTB(1), ARHGEF2(1), CLDN1(1), CTTN(3), EZR(1), FYN(1), HCLS1(2), KRT18(1), NCK2(1), OCLN(1), PRKCA(1), ROCK1(1), ROCK2(1), TLR4(1), TLR5(2), TUBA3C(3), TUBA3E(1), TUBA4A(1), TUBA8(1), TUBAL3(2), TUBB2B(2), TUBB8(3)	19343457	34	29	33	9	5	7	7	9	6	0	0.330	0.984	1.000
349	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	SDHA(1)	3462884	1	1	1	0	0	0	1	0	0	0	0.815	0.984	1.000
350	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(2), STAT5A(1)	6612993	3	3	3	1	1	0	2	0	0	0	0.715	0.985	1.000
351	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ELOVL2(1), FADS1(1), FADS2(1), FASN(3), HSD17B12(1)	5582821	7	7	7	3	1	2	2	1	1	0	0.653	0.985	1.000
352	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ARHGAP5(1), ARHGEF1(1), ARHGEF11(1), ARHGEF5(1), ARPC1B(1), BAIAP2(2), DIAPH1(2), LIMK1(2), MYLK(3), OPHN1(1), PIP5K1A(1), PIP5K1B(1), PPP1R12B(1), ROCK1(1), TLN1(2)	16981168	21	16	21	4	5	4	5	4	3	0	0.219	0.985	1.000
353	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	GNE(1), HK2(2)	6289088	3	3	3	1	1	0	1	1	0	0	0.798	0.986	1.000
354	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	ITGAM(2), ITGB2(1), SELL(1)	3972147	4	4	4	3	1	1	0	1	1	0	0.879	0.987	1.000
355	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNA1(1), IFNAR1(1), JAK1(1), STAT1(2)	4062865	5	5	5	6	0	1	2	1	1	0	0.986	0.987	1.000
356	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAD9(1), ADH4(2), ADH7(3), AKR1B10(1), AKR1C4(1), AKR1D1(2), ALDH1A3(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), CEL(3), CYP27A1(1), LIPA(1), SLC27A5(1), SOAT1(1), SOAT2(1)	11842612	23	18	23	6	3	5	5	5	5	0	0.348	0.987	1.000
357	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	92	ACTB(1), CABIN1(2), CAMK2B(1), CD3G(1), CDKN1A(2), CNR1(3), CREBBP(4), CTLA4(1), EGR2(1), EP300(2), FCER1A(1), FCGR3A(2), GATA3(1), GATA4(1), IFNA1(1), IFNG(1), JUNB(1), MAP2K7(2), MEF2B(2), MYF5(1), NCK2(1), NFAT5(4), NFATC2(1), P2RX7(1), PAK1(1), PIN1(1), PPP3CC(2), PTPRC(4), RELA(2), RPL13A(1), SLA(2), SP1(2), SP3(2), TGFB1(1), TNF(1), TRAF2(2), TRPV6(2), VAV1(3), VAV2(3), VAV3(1)	33558926	68	50	68	11	11	13	18	14	12	0	0.0152	0.988	1.000
358	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	ANKHD1(1), EEF1G(2), EIF2AK3(2), EIF2B3(1), EIF2S2(1), EIF4A2(2), EIF4G1(1), EIF4G3(3), EIF5B(1), GSPT2(1), PABPC1(2), PABPC3(2), PAIP1(1), SLC35A4(1)	16391173	21	17	21	4	3	7	1	5	5	0	0.210	0.989	1.000
359	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CD3G(1), ETV5(2), IFNG(1), IL12RB1(1), IL12RB2(3), IL18R1(1), MAP2K6(2), STAT4(1)	6972139	12	11	12	7	0	3	2	4	3	0	0.894	0.989	1.000
360	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(1), DHCR7(1), FDPS(2), GGCX(1), IDI1(1), TM7SF2(1)	7147873	7	7	7	3	1	1	2	1	2	0	0.796	0.989	1.000
361	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(1), GNAS(2), PLCE1(4), PRKAR2B(1)	5396535	8	8	8	6	3	2	0	1	2	0	0.937	0.990	1.000
362	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCR3(1), GNAS(2), LIMK1(2), MAPK1(1), NOX1(1), PIK3C2G(7), PLCB1(4), PPP1R12B(1), PRKCA(1), PTK2(3), ROCK2(1)	9407742	24	20	24	9	1	6	6	7	4	0	0.749	0.990	1.000
363	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(5), CDC25B(1), MYT1(2)	5032919	8	7	8	5	0	4	2	1	1	0	0.929	0.991	1.000
364	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ALDH1A3(2), AOC3(1), DDC(2), EPX(2), ESCO2(1), HPD(1), MAOB(1), MPO(4), PNPLA3(1), SH3GLB1(1), TAT(2), TPO(1)	12365103	19	15	19	5	4	8	3	0	4	0	0.184	0.991	1.000
365	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CREBBP(4), EP300(2), PRKAR2B(1), RARA(1), RXRA(1)	7456995	9	8	9	4	2	1	1	2	3	0	0.864	0.991	1.000
366	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(2), BST1(2), ENPP3(2), NADK(1), NMNAT1(1), NT5E(1), NUDT12(1)	7926667	10	9	10	5	2	2	2	1	2	1	0.793	0.991	1.000
367	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(1), JAK3(2), MAPK1(1)	4482752	4	4	4	4	1	0	1	1	1	0	0.982	0.991	1.000
368	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	CASP4(2), LMNB1(1)	7040498	3	3	3	1	0	3	0	0	0	0	0.553	0.991	1.000
369	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	25	IRS1(1), MAPK1(1), PIK3CA(6), PIK3R1(1), PLCG1(2), PRKCA(1), RPS6KA1(1), SLC2A4(1), SRF(1), STAT5A(1)	12138491	16	16	15	5	2	2	2	4	5	1	0.611	0.992	1.000
370	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	CHRNG(1), MUSK(1), PIK3CA(6), PIK3R1(1), PTK2(3), PTK2B(2), TERT(1)	6161635	15	12	14	5	2	2	3	4	4	0	0.475	0.992	1.000
371	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	ITGA4(1), ITGB2(1), SELL(1)	4542968	3	3	3	2	1	0	1	1	0	0	0.901	0.992	1.000
372	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1R(2), E2F4(2), ETV3(1), HDAC5(1), NCOR2(3), SIN3A(1)	10044095	10	8	10	2	1	4	2	3	0	0	0.237	0.993	1.000
373	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	IFNA1(1), IL1A(1), IL1RN(1), IRAK2(1), IRAK3(2), MAP2K3(2), MAP2K6(2), MAP3K7(1), NFKB1(1), RELA(2), TGFB1(1), TNF(1), TRAF6(2)	11025206	18	17	18	5	3	2	6	6	1	0	0.491	0.993	1.000
374	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	BTK(1), FCER1A(1), LYN(1), MAP2K4(2), MAP2K7(2), MAPK1(1), NFATC2(1), PIK3CA(6), PIK3R1(1), PLA2G4A(1), PLCG1(2), PPP3CC(2), SYK(1), SYT1(1), VAV1(3)	15665266	26	23	25	7	4	4	3	8	7	0	0.419	0.994	1.000
375	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	ADCY1(1), CAMK2B(1), CAMK2G(1), GNAS(2), MAPK1(1), PIK3CA(6), PIK3R1(1), PRKAR2B(1), PRKCA(1), RAC1(1), RPS6KA1(1)	10751678	17	17	16	6	3	2	2	4	6	0	0.700	0.994	1.000
376	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	HK2(2), PGM1(1), TGDS(1)	3809371	4	3	4	2	1	1	1	0	1	0	0.724	0.994	1.000
377	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT6(2), ENPP2(2), PAFAH1B3(1), PAFAH2(2), PLA2G12B(1), PLA2G2D(1), PLA2G4A(1), PLD1(2), PPAP2A(1), PPAP2C(1)	8727858	14	12	14	7	4	3	2	1	4	0	0.862	0.994	1.000
378	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOB(2), GPT2(2), ME1(1), ME3(1), PGK2(1), PKLR(2), TKT(1), TKTL1(2), TKTL2(1)	7238638	13	12	13	6	5	0	3	2	3	0	0.738	0.995	1.000
379	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(1), JAK1(1), PTPRU(7), STAT1(2)	4669703	11	11	11	8	2	2	3	3	1	0	0.938	0.995	1.000
380	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	LCT(4), MAN2C1(1), NEU3(2)	6052279	7	6	7	4	1	1	2	0	2	1	0.768	0.995	1.000
381	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	GUSB(2), UGDH(1), UGT1A10(1), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT2B15(1)	6396210	9	9	9	5	4	2	0	1	2	0	0.848	0.995	1.000
382	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	DPM2(1), EGFR(2), GNAS(2), IGF1R(1), MAP2K2(1), MAPK1(1), MYC(3), NGFR(1), PDGFRA(1), PTPRR(2), RPS6KA1(1)	12464322	16	11	16	4	5	4	1	3	3	0	0.307	0.995	1.000
383	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	GNE(1), HK2(2), LHPP(2)	10645646	5	5	5	0	2	0	2	1	0	0	0.258	0.995	1.000
384	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(1), ACACA(1), ACACB(2), ACAT1(1), ACSS2(2), ALDH1A3(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), LDHB(1), MUT(2)	14489006	15	15	15	4	1	1	5	4	4	0	0.596	0.995	1.000
385	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(2), ENPP3(2), NMNAT1(1), NT5E(1)	5331520	6	6	6	4	1	2	2	0	1	0	0.882	0.995	1.000
386	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	BTK(1), CDKN2A(1), IARS(1), INPP5D(3), PIK3CA(6), PPP1R13B(1), PTEN(8), RPS6KA1(1), TEC(2), YWHAE(1)	13153299	25	22	24	9	4	5	1	9	6	0	0.754	0.996	1.000
387	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(1), ACADL(1), ACADSB(1), ALDH1A2(1), ALDH1A3(2), ALDH2(1), ALDH9A1(1), AOC3(1), DPYD(6), GAD1(1), GAD2(2)	10594907	18	14	18	6	1	5	3	5	4	0	0.484	0.996	1.000
388	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(1), GNAS(2), PRKAA2(4), PRKAB2(1), PRKAR2B(1)	5675046	9	7	9	4	2	3	2	1	1	0	0.755	0.996	1.000
389	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	30	CABIN1(2), HDAC5(1), IGF1(1), IGF1R(1), MAP2K6(2), MAPK7(1), MEF2B(2), MEF2C(1), NFATC2(1), PIK3CA(6), PIK3R1(1), PPP3CC(2), SYT1(1)	12839261	22	18	21	5	2	4	4	7	5	0	0.284	0.996	1.000
390	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	CRY1(2), CRY2(1), G0S2(1), IDI1(1), MYF6(1), NCKAP1(2), NCOA4(1), NR1D2(1), PER1(3), PER2(1), SF3A3(1), SUMO3(2), UGP2(1), ZFR(1)	13383825	19	18	19	5	1	7	2	4	5	0	0.564	0.996	1.000
391	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2R(1), ITGA1(1), MAPK1(1), PLA2G4A(1), PLCB1(4), PRKCA(1), PTK2(3), SYK(1), TBXAS1(1)	8965678	14	12	14	6	1	3	4	3	3	0	0.850	0.996	1.000
392	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH4(2), ADH7(3), ALDH1A2(1), ALDH1A3(2), ALDH2(1), ALDH9A1(1), CEL(3), DGKB(1), DGKD(2), DGKE(1), DGKG(3), DGKH(2), GLA(1), LCT(4), LIPC(3), LIPF(1), LPL(2), PNLIPRP1(1), PPAP2A(1), PPAP2C(1)	18030191	36	28	35	9	4	8	10	7	7	0	0.255	0.996	1.000
393	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	PRKAR2B(1)	4648994	1	1	1	6	0	0	0	0	1	0	1.000	0.996	1.000
394	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	35	ARHGEF11(1), MAP2K4(2), MAP3K5(4), NFKB1(1), NFKBIL1(1), PHKA2(2), PI3(1), PIK3CB(1), PLD1(2), PTK2(3), RDX(1), ROCK1(1), ROCK2(1), SERPINA4(1), SRF(1)	18463537	23	19	23	5	3	5	2	9	3	1	0.337	0.997	1.000
395	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(1), ABCC2(2), CES1(1), CYP3A4(2), UGT1A10(1), UGT1A4(1), UGT1A5(2), UGT1A6(1)	8298566	11	11	11	7	4	1	2	1	3	0	0.915	0.997	1.000
396	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ADCY1(1), GNAS(2), MAPK1(1), MYT1(2), PIN1(1), PRKAR2B(1), RPS6KA1(1)	7545398	9	7	9	6	2	3	0	1	3	0	0.916	0.997	1.000
397	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(1), GPLD1(1), PGAP1(2), PIGB(1), PIGC(1), PIGG(1), PIGN(3), PIGT(1)	9131825	11	9	11	4	0	7	0	3	1	0	0.449	0.997	1.000
398	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	32	MAP2K3(2), MAP2K4(2), MAP2K6(2), MAP3K7(1), NFKB1(1), PPARA(1), RELA(2), TIRAP(1), TLR2(3), TLR3(2), TLR4(1), TLR9(2), TRAF6(2)	13440229	22	19	22	6	2	4	5	9	2	0	0.363	0.997	1.000
399	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	34	IL2RB(4), IL2RG(1), IRS1(1), JAK1(1), JAK3(2), MAPK1(1), MYC(3), NMI(1), PIK3CA(6), PIK3R1(1), STAT5A(1), SYK(1)	13502906	23	19	22	6	6	3	4	5	5	0	0.378	0.997	1.000
400	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(1), ALDH1A3(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), AOC3(1), DPYD(6), GAD1(1), GAD2(2)	9858766	16	12	16	6	1	5	3	3	4	0	0.556	0.997	1.000
401	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(1), CFTR(6), GNAS(2), PRKAR2B(1)	4827266	10	9	10	6	3	1	0	5	1	0	0.902	0.997	1.000
402	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	37	ANPEP(1), GCLC(1), GGT1(1), GPX5(2), GSTA4(1), GSTM5(1), IDH1(2)	8323747	9	8	9	6	2	1	3	0	3	0	0.961	0.997	1.000
403	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(2), IL22RA1(1), JAK1(1), JAK3(2), STAT1(2), STAT5A(1)	7003827	9	8	9	4	2	2	2	1	2	0	0.663	0.997	1.000
404	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CR1(3), CR2(2), FCGR2B(1), HLA-DRB1(1), ITGB2(1), PTPRC(4)	5597588	12	10	12	5	3	5	3	0	1	0	0.599	0.998	1.000
405	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2B(1), CAMK2G(1), ITPKA(1), ITPR1(4), ITPR2(6), ITPR3(2), NFAT5(4), PDE6A(1), PDE6B(3), PDE6C(1), SLC6A13(1), TF(1)	13192253	26	22	26	7	9	4	4	3	6	0	0.232	0.998	1.000
406	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	DLAT(1), IDH3A(1), IDH3B(1), IDH3G(1), PDHA2(2), PDHB(1), PDHX(1), SDHA(1)	10469823	9	8	9	2	1	4	3	1	0	0	0.324	0.998	1.000
407	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	27	ADRBK1(1), ITPKA(1), ITPR1(4), ITPR2(6), ITPR3(2), NFKB1(1), NFKBIL1(1), PHKA2(2), PIK3CB(1), PLD1(2), VN1R1(1)	16943954	22	20	22	5	7	5	2	4	4	0	0.234	0.998	1.000
408	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	HK2(2), PGM1(1), TGDS(1)	4370355	4	3	4	2	1	1	1	0	1	0	0.709	0.998	1.000
409	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(1), CD3G(1), CREBBP(4), GNAS(2), HLA-DRB1(1), LCK(1), PRKAR2B(1), PTPRC(4), ZAP70(5)	8437568	20	18	20	7	7	5	3	2	3	0	0.520	0.998	1.000
410	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(1), CD3G(1), CREBBP(4), GNAS(2), HLA-DRB1(1), LCK(1), PRKAR2B(1), PTPRC(4), ZAP70(5)	8437568	20	18	20	7	7	5	3	2	3	0	0.520	0.998	1.000
411	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(1), AGTR2(1), CAMK2B(1), CAMK2G(1), FYN(1), GNA11(1), MAP2K2(1), MAPK1(1), MAPT(1), MYLK(3), PLCG1(2), PRKCA(1), PTK2B(2), STAT1(2), STAT5A(1), SYT1(1)	15510767	21	16	21	5	3	5	4	2	7	0	0.238	0.998	1.000
412	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CD3G(1), IFNG(1), IL12RB1(1), IL12RB2(3), STAT4(1)	5504250	7	7	7	5	0	3	2	1	1	0	0.920	0.998	1.000
413	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARFGEF2(1), GBF1(3), GPLD1(1)	5911936	5	4	5	2	1	2	2	0	0	0	0.713	0.998	1.000
414	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	GUSB(2), UGDH(1), UGP2(1), UGT1A10(1), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT2A3(1), UGT2B11(3), UGT2B15(1), UGT2B17(2)	9907577	16	14	16	5	5	5	2	2	2	0	0.489	0.998	1.000
415	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOB(2), GPT2(2), ME1(1), ME3(1), PKLR(2), TKT(1)	6507079	9	9	9	5	5	0	1	1	2	0	0.762	0.998	1.000
416	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLRMT(1)	5006457	1	1	1	3	0	0	0	0	1	0	1.000	0.998	1.000
417	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	ITGA4(1), ITGAM(2), ITGB2(1), SELL(1), SELP(2)	6007642	7	7	7	5	1	1	2	2	1	0	0.927	0.999	1.000
418	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	IRS1(1), PIK3CA(6), PIK3R1(1), PTPN11(3), RASA1(2), SLC2A4(1), SRF(1)	9352281	15	13	14	5	2	4	2	4	2	1	0.520	0.999	1.000
419	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	13	IKBKAP(2), NFKB1(1), RELA(2), TRAF6(2)	6801910	7	6	7	3	1	3	1	2	0	0	0.657	0.999	1.000
420	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ASPH(3), EP300(2), EPO(1), NOS3(2)	6287377	8	8	8	6	0	1	2	4	1	0	0.952	0.999	1.000
421	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AP2A1(2), AP2M1(2), DNM1(2), NME2(1), PPP3CC(2), SYNJ1(1), SYNJ2(1), SYT1(1)	8415720	12	9	12	5	1	4	3	1	3	0	0.712	0.999	1.000
422	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCL3(1), CCR1(1), CCR3(1), CCR4(1), IFNG(1), IL12RB1(1), IL12RB2(3), IL18R1(1), TGFB1(1)	7358740	11	11	11	5	1	3	4	1	2	0	0.619	0.999	1.000
423	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(2), ACO1(3), CLYBL(1), IDH1(2), IDH3A(1), IDH3B(1), IDH3G(1), OGDHL(3), SDHA(1)	10930539	15	13	15	5	2	6	3	1	3	0	0.364	0.999	1.000
424	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	DRD1(1), DRD2(1), GRM1(1), PLCB1(4), PRKAR2B(1)	5751073	8	7	8	4	1	3	0	3	1	0	0.755	0.999	1.000
425	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ALPI(1), ALPL(3), ALPP(1), CYP19A1(1), CYP1A2(2), CYP2A13(1), CYP2A6(1), CYP2C18(3), CYP2C19(2), CYP2C9(2), CYP2E1(2), CYP2F1(2), CYP2J2(2), CYP3A4(2), CYP3A7(1), CYP4B1(1)	10928803	27	20	27	9	4	9	7	2	5	0	0.262	0.999	1.000
426	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACADL(1), ACADSB(1), ACAT1(1), ALDH1A2(1), ALDH1A3(2), ALDH2(1), ALDH9A1(1), AOX1(2), BCKDHA(1), MCCC1(1), MUT(2)	13231432	14	13	14	4	0	3	3	6	2	0	0.541	0.999	1.000
427	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXTL3(2), GLCE(2), HS3ST1(1), HS3ST3A1(1), HS3ST3B1(1), HS3ST5(2), HS6ST1(1), NDST3(3), NDST4(3)	7691080	16	14	16	9	3	5	3	3	2	0	0.845	0.999	1.000
428	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	52	AGT(1), CREBBP(4), ELSPBP1(2), GATA4(1), IGF1(1), MAPK1(1), MEF2C(1), MYH2(6), NFATC2(1), NKX2-5(1), PIK3CA(6), PIK3R1(1), PPP3CC(2), PRKAR2B(1), SYT1(1)	18401574	30	24	29	9	3	4	6	5	12	0	0.753	0.999	1.000
429	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AOC3(1), CES1(1), ESCO2(1), LIPA(1), PLA1A(2), PNPLA3(1), SH3GLB1(1)	9031357	8	7	8	3	3	3	1	0	1	0	0.535	0.999	1.000
430	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(1), GPRC5B(1), GPRC5C(3), GRM1(1), GRM3(5), GRM4(1), GRM5(4), GRM7(2), GRM8(2)	7481685	20	14	20	8	5	7	3	4	1	0	0.409	0.999	1.000
431	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	LCT(4), MAN2B2(1), MAN2C1(1), NEU3(2)	7470158	8	7	8	4	2	1	2	0	2	1	0.669	0.999	1.000
432	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	28	BRAF(1), EGFR(2), ERBB4(4), ETV7(1), FMN2(5), KRAS(2), MAPK1(1), NOTCH1(1), NOTCH2(1), NOTCH3(3), NOTCH4(6), PIWIL1(2), PIWIL2(1), PIWIL3(1), SPIRE1(2)	19676771	33	24	33	9	8	7	8	6	3	1	0.293	0.999	1.000
433	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOB(2), DERA(1), H6PD(2), PFKL(2), PFKP(1), PGM1(1), TKT(1), TKTL1(2), TKTL2(1)	8949270	13	10	13	6	2	2	4	1	4	0	0.690	0.999	1.000
434	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(1), EPHB2(1), MAP2K5(1), MAPK1(1), MAPK7(1), PLD1(2), PTK2(3), RASAL1(1), TEC(2), VAV1(3)	10194330	16	14	16	7	5	1	3	4	3	0	0.825	0.999	1.000
435	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	27	IRS1(1), JAK1(1), JAK3(2), MAP4K1(3), MAPK1(1), PIK3CA(6), PIK3CD(1), PIK3R1(1), PPP1R13B(1)	13451939	17	16	16	7	4	0	3	4	6	0	0.808	0.999	1.000
436	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(1), ACACB(2), ACAT1(1), ACSS2(2), ALDH1A3(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), DLAT(1), GRHPR(1), LDHB(1), ME1(1), ME3(1), PDHA2(2), PDHB(1), PKLR(2)	17083347	21	18	21	5	3	3	7	4	4	0	0.325	0.999	1.000
437	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(3), ATP5B(1), ATP5C1(1), ATP5J2(1), ATP5O(1), ATP6AP1(2), ATP6V0A4(1), ATP6V1A(2), ATP6V1E1(1), COX10(1), COX6A2(1), LHPP(2), NDUFA13(1), NDUFA7(2), NDUFV3(1), SDHA(1), TCIRG1(1), UQCRB(1), UQCRC1(1)	20835732	25	24	25	6	4	4	10	2	5	0	0.323	0.999	1.000
438	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(1), ABAT(1), ACAT1(1), ALDH1A2(1), ALDH1A3(2), ALDH2(1), ALDH9A1(1), GAD1(1), GAD2(2), PDHA2(2), PDHB(1)	9468360	14	12	14	6	0	4	3	5	2	0	0.738	0.999	1.000
439	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	GRIN1(2), GRIN2A(2), GRIN2D(1), NOS1(6), PPP3CC(2), PRKAR2B(1), PRKCA(1), SYT1(1)	9313710	16	14	16	8	3	4	4	2	3	0	0.800	0.999	1.000
440	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	144	APC(5), AXIN1(1), AXIN2(2), BTRC(1), CAMK2B(1), CAMK2G(1), CCND1(1), CHD8(3), CREBBP(4), CTBP1(1), CUL1(3), DKK2(1), DVL1(2), EP300(2), FZD2(1), FZD3(2), FZD5(1), FZD6(1), LRP5(2), MAP3K7(1), MAPK10(2), MMP7(1), MYC(3), NFAT5(4), NFATC2(1), NKD2(2), PLCB1(4), PLCB2(1), PLCB3(1), PLCB4(3), PORCN(2), PPP2R1A(1), PPP2R1B(1), PPP2R2A(1), PPP2R2B(1), PPP2R2C(1), PPP3CC(2), PRICKLE1(1), PRKACA(2), PRKCA(1), PRKCG(1), RAC1(1), ROCK1(1), ROCK2(1), SMAD3(1), SOX17(1), TCF7L1(1), TCF7L2(1), TP53(90), VANGL1(1), WIF1(3), WNT10B(1), WNT2(1), WNT5A(1), WNT7B(1), WNT8A(1), WNT8B(1)	58794795	179	114	164	32	25	32	27	35	60	0	0.000470	0.999	1.000
441	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	BAIAP2(2), GAPDH(1), MAGI1(3), MAGI2(3), RERE(2), WWP1(2), WWP2(1)	8528670	14	12	14	5	1	4	2	5	2	0	0.598	1.000	1.000
442	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(2), BTK(1), LYN(1), NFATC2(1), PLCG1(2), PPP3CC(2), PRKCA(1), RAC1(1), SYK(1), SYT1(1), VAV1(3)	13930385	16	15	16	9	3	2	3	3	5	0	0.931	1.000	1.000
443	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	47	FN3K(1), INPP1(1), INPP4B(1), INPP5A(1), INPP5B(2), INPPL1(1), ITPK1(2), ITPKA(1), PI4KA(3), PI4KB(1), PIK3CA(6), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIP5K1A(1), PIP5K1B(1), PLCB1(4), PLCB2(1), PLCB3(1), PLCB4(3), PLCD3(1), PLCE1(4), PLCG1(2), PLCZ1(1), PTEN(8), SYNJ1(1), SYNJ2(1)	27582535	53	37	52	11	12	14	2	13	12	0	0.0452	1.000	1.000
444	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	IARS(1), IARS2(1), ILVBL(1), PDHA2(2), PDHB(1)	6800822	6	6	6	3	0	2	3	1	0	0	0.797	1.000	1.000
445	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	GBA(1), GNS(1), GUSB(2), HPSE2(3), IDUA(2), LCT(4), MAN2B2(1), MAN2C1(1), NAGLU(1), NEU3(2), SPAM1(2)	12929886	20	16	20	6	6	3	4	2	4	1	0.235	1.000	1.000
446	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	ALDOB(2), FPGT(2), GMDS(1), GMPPA(1), HK2(2), KHK(1), PFKFB1(1), PFKFB4(3), PFKP(1)	8874601	14	13	14	5	7	1	3	0	3	0	0.475	1.000	1.000
447	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(2), ANAPC2(2), ANAPC4(1), ANAPC5(1), BTRC(1), CUL1(3), CUL3(1), FZR1(2), SMURF2(1), UBA1(1), UBE2C(1), WWP1(2), WWP2(1)	15021301	19	16	19	5	5	3	2	7	2	0	0.367	1.000	1.000
448	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(1), CAMK2B(1), CAMK2G(1), CLCA1(1), CLCA2(1), CNGA3(4), CNGB1(1), GNAL(1), GUCA1C(1), PDE1C(4), PRKACA(2), PRKG1(1), PRKG2(1)	11239764	20	16	20	9	2	5	5	4	4	0	0.720	1.000	1.000
449	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA2C(1), CHRM1(1), CHRM2(1), CHRM4(1), CHRM5(1), DRD1(1), DRD2(1), DRD3(2), HTR1A(1), HTR1D(2), HTR2A(1), HTR4(1), HTR6(1)	9270164	15	13	15	6	3	6	4	2	0	0	0.334	1.000	1.000
450	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ACY1(1), AGMAT(1), ALDH18A1(1), ALDH1A3(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), AOC3(1), ARG2(2), CPS1(1), MAOB(1)	10880747	13	13	13	6	2	3	4	1	3	0	0.760	1.000	1.000
451	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	MAP2K3(2), MAP2K4(2), MAP2K6(2), MAP3K5(4), MAP3K7(1), MAPK1(1), MAPK11(1), NFKB1(1), SRF(1), TRAF6(2)	12584371	17	14	17	8	2	3	3	6	2	1	0.825	1.000	1.000
452	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(1), ACAT1(1), ALDH1A3(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), AOX1(2), BCKDHA(1), DBT(1), HMGCS1(1), HMGCS2(1), HSD17B4(1), MCCC1(1), MUT(2), OXCT2(1)	15951917	18	17	18	6	2	3	4	4	5	0	0.612	1.000	1.000
453	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(1), ALOX12(2), ALOX15(1), ALOX5(1), CBR3(1), CYP4F2(2), EPX(2), GGT1(1), MPO(4), PLA2G4A(1), PTGIS(1), PTGS2(1), TBXAS1(1), TPO(1)	10609431	20	16	20	7	3	8	4	2	3	0	0.327	1.000	1.000
454	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS2(2), ADH4(2), ADH7(3), ALDH1A3(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), ALDOB(2), DLAT(1), ENO1(1), ENO2(2), G6PC2(1), GAPDH(1), HK2(2), LDHB(1), PDHA2(2), PDHB(1), PFKL(2), PFKP(1), PGK2(1), PGM1(1), PKLR(2)	21542974	33	26	33	9	5	5	9	5	9	0	0.328	1.000	1.000
455	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	EPO(1), PLCG1(2), STAT5A(1)	8127268	4	4	4	3	1	0	1	1	1	0	0.891	1.000	1.000
456	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(1), ALG11(1), ALG13(1), ALG2(1), ALG6(1), ALG9(1), DHDDS(1), FUT8(1), MAN1A1(3), MAN1B1(1), MAN1C1(2), MGAT3(1), MGAT5B(2), RPN2(2)	15753090	19	14	19	6	3	5	2	3	5	1	0.410	1.000	1.000
457	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	CHN1(1), LIMK1(2), MYLK(3), PAK1(1), PDGFRA(1), PIK3CA(6), PIK3R1(1), PLD1(2), PPP1R12B(1), RAC1(1), TRIO(2), VAV1(3)	12804766	24	19	23	8	5	3	6	7	3	0	0.577	1.000	1.000
458	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(1), GNAS(2), NFATC2(1), PLCG1(2), PPP3CC(2), PRKAR2B(1), PRKCA(1), SYT1(1)	12768406	11	11	11	6	2	1	2	2	4	0	0.928	1.000	1.000
459	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	18	IKBKAP(2), NFKB1(1), RELA(2), RIPK1(2), TRAF2(2)	8300241	9	9	9	5	1	5	1	1	1	0	0.796	1.000	1.000
460	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(2), LIPC(3), LPL(2), LRP1(4), SOAT1(1)	10019042	12	11	12	7	2	4	3	1	2	0	0.754	1.000	1.000
461	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOB(2), DLAT(1), ENO1(1), ENO2(2), GAPDH(1), HK2(2), LDHB(1), PDHA2(2), PDHB(1), PDHX(1), PFKL(2), PFKP(1), PGK2(1), PKLR(2), TNFAIP1(1)	15603326	21	18	21	5	4	3	5	4	5	0	0.298	1.000	1.000
462	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	99	CCL3(1), CD86(1), IFNA1(1), IFNA14(1), IFNA16(1), IFNA17(1), IFNA8(1), IFNAR1(1), IRF3(1), IRF5(1), LBP(1), MAP2K2(1), MAP2K3(2), MAP2K4(2), MAP2K6(2), MAP2K7(2), MAP3K7(1), MAPK1(1), MAPK10(2), MAPK11(1), NFKB1(1), PIK3CA(6), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(1), PIK3R3(1), RAC1(1), RELA(2), RIPK1(2), STAT1(2), TICAM1(2), TIRAP(1), TLR1(1), TLR2(3), TLR3(2), TLR4(1), TLR5(2), TLR8(1), TLR9(2), TNF(1), TRAF6(2)	32655030	63	43	62	12	11	15	11	16	10	0	0.0198	1.000	1.000
463	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOB(2), H6PD(2), PFKP(1), PGM1(1), TKT(1)	7396967	7	6	7	5	2	1	3	0	1	0	0.851	1.000	1.000
464	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ALDH1A2(1), ALDH1A3(2), ALDH2(1), ALDH9A1(1), AOC3(1), ASPA(1), DDC(2), HDC(3), MAOB(1)	9047188	13	12	13	6	5	2	2	3	1	0	0.691	1.000	1.000
465	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTN1(1), BCAR1(1), BCR(2), CAPN1(1), CAPNS1(1), FYN(1), ITGA1(1), MAP2K2(1), MAPK1(1), PPP1R12B(1), PTK2(3), RAP1A(1), ROCK1(1), TLN1(2)	17678684	18	17	18	5	3	2	4	5	4	0	0.548	1.000	1.000
466	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG2(1), ADCY3(1), ADCY9(1), ATP6V0A4(1), ATP6V1A(2), ATP6V1E1(1), GNAS(2), PDIA4(1), PLCG1(2), PRKCA(1), SEC61A2(1), SEC61B(1)	13604814	15	13	15	6	2	4	2	4	3	0	0.735	1.000	1.000
467	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	ABAT(1), ADSL(1), AGXT2(1), ASNS(1), ASPA(1), DARS(1), GAD1(1), GAD2(2), GPT2(2)	9598797	11	9	11	7	2	4	1	3	1	0	0.856	1.000	1.000
468	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	33	BCR(2), BTK(1), CDKN2A(1), GAB1(1), ITPR1(4), ITPR2(6), ITPR3(2), LYN(1), PIK3CA(6), PPP1R13B(1), PREX1(2), PTEN(8), PTPRC(4), RPS6KA1(1), SAG(1), SYK(1), TEC(2), VAV1(3)	20679530	47	42	46	13	13	4	9	13	8	0	0.343	1.000	1.000
469	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	63	CDKN2A(1), ERBB4(4), GAB1(1), IGF1(1), INPPL1(1), IRS1(1), IRS4(3), MET(4), MYC(3), NOLC1(1), PAK1(1), PAK3(3), PAK4(1), PAK7(1), PIK3CA(6), PIK3CD(1), PPP1R13B(1), PREX1(2), PTEN(8), PTK2(3), RPS6KA1(1), SLC2A4(1), TSC1(1), TSC2(4), YWHAE(1)	28210022	55	45	54	13	10	12	7	14	12	0	0.188	1.000	1.000
470	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B10(1), G6PC2(1), GAA(1), GALK1(1), GLA(1), HK2(2), LCT(4), MGAM(5), PFKL(2), PFKP(1), PGM1(1), UGP2(1)	14371379	21	18	21	7	4	7	6	1	3	0	0.364	1.000	1.000
471	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	GTF2B(1), HDAC3(1), NCOA1(1), NCOR2(3), RARA(1), RXRA(1)	9270043	8	7	8	4	1	2	1	3	1	0	0.790	1.000	1.000
472	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	ANGPTL2(2), ARHGEF11(1), BTK(1), GDI1(1), INPPL1(1), ITPR1(4), ITPR2(6), ITPR3(2), LIMK1(2), MYLK(3), MYLK2(2), PAK1(1), PAK3(3), PAK4(1), PAK7(1), PIK3CA(6), PIK3CD(1), PIK3CG(2), PIK3R1(1), PPP1R13B(1), PTEN(8), RHO(1), ROCK1(1), ROCK2(1), SAG(1)	25915311	54	42	53	13	10	11	9	15	9	0	0.168	1.000	1.000
473	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH4(2), ADH7(3), ALDH1A2(1), ALDH1A3(2), ALDH2(1), ALDH9A1(1), ALDOB(2), DLAT(1), ENO1(1), ENO2(2), GAPDH(1), HK2(2), LDHB(1), PDHA2(2), PDHB(1), PFKP(1), PGM1(1), PKLR(2)	18013698	27	21	27	9	5	5	6	5	6	0	0.553	1.000	1.000
474	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH4(2), ADH7(3), ALDH1A2(1), ALDH1A3(2), ALDH2(1), ALDH9A1(1), ALDOB(2), DLAT(1), ENO1(1), ENO2(2), GAPDH(1), HK2(2), LDHB(1), PDHA2(2), PDHB(1), PFKP(1), PGM1(1), PKLR(2)	18013698	27	21	27	9	5	5	6	5	6	0	0.553	1.000	1.000
475	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	GAS2(1), NFKB1(1), RELA(2), RIPK1(2), SPTAN1(3), TRAF2(2)	12305350	11	10	11	5	2	4	2	0	3	0	0.839	1.000	1.000
476	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B4GALT5(2), GALNT10(1), GALNT13(1), GALNT14(3), GALNT3(1), GALNT5(1), GALNT7(1), GALNT8(2), GALNTL5(1), OGT(1), ST6GALNAC1(1), WBSCR17(2)	11872599	17	11	17	9	2	9	3	1	2	0	0.680	1.000	1.000
477	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	DPYD(6), DTYMK(1), ENTPD1(1), NME2(1), NT5E(1), POLD1(2), POLE(5), POLG(1), POLQ(6), POLRMT(1), RRM2(1), TXNRD1(4), UMPS(1)	21268277	31	20	31	7	2	10	10	5	4	0	0.175	1.000	1.000
478	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(3), ATP5O(1), ATP6AP1(2), ATP6V0A4(1), ATP6V1A(2), ATP6V1E1(1), ATP7B(2), COX10(1), COX6A2(1), SDHA(1), UQCRB(1), UQCRC1(1)	14014550	17	16	17	6	2	2	9	2	2	0	0.636	1.000	1.000
479	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B10(1), ALDOB(2), FPGT(2), GMDS(1), GMPPA(1), HK2(2), KHK(1), LHPP(2), PFKFB1(1), PFKFB2(1), PFKFB4(3), PFKL(2), PFKP(1)	14012876	20	18	20	7	8	1	6	0	5	0	0.400	1.000	1.000
480	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(4), C5(2), C6(4), C7(1), IL1A(1), ITGA4(1), ITGB2(1), SELP(2), SELPLG(1), TNF(1), VCAM1(1)	9142773	19	18	19	8	3	2	6	7	1	0	0.708	1.000	1.000
481	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	70	ADH4(2), ADH7(3), AKR1C3(1), AKR1C4(1), ALDH1A3(2), CYP1A2(2), CYP2C18(3), CYP2C19(2), CYP2C9(2), CYP2E1(2), CYP2F1(2), CYP2S1(2), CYP3A4(2), CYP3A7(1), DHDH(1), EPHX1(1), GSTA4(1), GSTM5(1), UGT1A10(1), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT2A3(1), UGT2B11(3), UGT2B15(1), UGT2B17(2)	21281307	43	30	43	12	8	10	9	7	9	0	0.240	1.000	1.000
482	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	BRAF(1), DUSP9(1), MAP2K2(1), MAPK1(1), NFKB1(1), RAP1A(1), RPS6KA1(1)	10991541	7	7	7	7	1	3	1	1	1	0	0.975	1.000	1.000
483	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	APC(5), CAMP(1), EPHB2(1), ITPR1(4), ITPR2(6), ITPR3(2), KCNJ3(1), KCNJ5(2), MAPK1(1), RAC1(1), RHO(1), RYR1(15)	17015236	40	29	40	12	12	12	3	4	9	0	0.101	1.000	1.000
484	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	37	CCNH(1), GTF2B(1), GTF2H1(1), POLR3E(1), TAF6(1)	12777232	5	5	5	4	1	1	1	0	2	0	0.916	1.000	1.000
485	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	CREBBP(4), CTBP1(1), DLL3(1), DTX1(3), DTX2(3), DTX3(2), DTX4(1), DVL1(2), EP300(2), JAG1(4), JAG2(1), MAML1(1), MAML3(4), NCOR2(3), NCSTN(1), NOTCH1(1), NOTCH2(1), NOTCH3(3), NOTCH4(6), NUMBL(8), PSEN2(1), SNW1(2)	26590954	55	35	48	15	11	14	4	7	18	1	0.241	1.000	1.000
486	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	78	ABL1(2), ACTN1(1), ANGPTL2(2), ARHGEF6(2), ARHGEF7(1), BCAR1(1), BRAF(1), CDKN2A(1), CSE1L(1), DOCK1(2), EPHB2(1), FYN(1), ITGA1(1), ITGA10(3), ITGA2(1), ITGA3(1), ITGA4(1), ITGA6(1), ITGA8(1), ITGA9(1), MAP2K4(2), MAP2K7(2), MAP3K11(1), MAPK1(1), MAPK10(2), MAPK8IP3(2), MYLK(3), MYLK2(2), PAK1(1), PAK3(3), PAK4(1), PAK7(1), PIK3CA(6), PIK3CB(1), PKLR(2), PLCG1(2), PTEN(8), PTK2(3), RHO(1), ROCK1(1), ROCK2(1), TLN1(2), TLN2(5), VASP(1)	45277232	80	59	79	16	14	17	12	22	15	0	0.0347	1.000	1.000
487	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	74	BTK(1), FCER1A(1), FYN(1), INPP5D(3), KRAS(2), LCP2(1), LYN(1), MAP2K2(1), MAP2K3(2), MAP2K4(2), MAP2K6(2), MAP2K7(2), MAPK1(1), MAPK10(2), MAPK11(1), MS4A2(3), NRAS(1), PIK3CA(6), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(1), PIK3R3(1), PLA2G12B(1), PLA2G2D(1), PLA2G4A(1), PLCG1(2), PRKCA(1), PRKCE(2), RAC1(1), SYK(1), TNF(1), VAV1(3), VAV2(3), VAV3(1)	26747960	57	39	56	16	9	13	5	19	11	0	0.258	1.000	1.000
488	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	ACHE(3), AGPAT6(2), CDIPT(1), CDS1(1), CHAT(1), DGKB(1), DGKD(2), DGKE(1), DGKG(3), DGKH(2), ESCO2(1), ETNK2(1), GPAM(1), GPD2(1), PLA2G12B(1), PLA2G2D(1), PLA2G4A(1), PLD1(2), PNPLA3(1), PPAP2A(1), PPAP2C(1), SH3GLB1(1)	24237423	30	23	29	9	8	7	6	4	5	0	0.347	1.000	1.000
489	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	GAA(1), GALK1(1), GLA(1), HK2(2), LCT(4), MGAM(5), PFKP(1), PGM1(1)	12056394	16	14	16	7	4	6	4	1	1	0	0.625	1.000	1.000
490	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACADL(1), ACADSB(1), ACAT1(1), ACSL3(1), ACSL4(2), ACSL6(3), ADH4(2), ADH7(3), ALDH1A3(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), CPT1A(1), CPT1B(1), CYP4A11(1), HSD17B4(1)	17981670	23	20	23	9	4	1	6	8	4	0	0.803	1.000	1.000
491	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(3), CDIPT(1), CDS1(1), CHAT(1), CPT1B(1), DGKB(1), DGKD(2), DGKE(1), DGKG(3), DGKH(2), GPD2(1), PAFAH2(2), PLA2G4A(1), PLCB2(1), PLCG1(2), PPAP2A(1), PPAP2C(1)	18686023	25	22	24	9	7	5	3	6	4	0	0.515	1.000	1.000
492	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	93	CARD11(3), CBLB(2), CBLC(1), CD3G(1), CD40LG(1), CDK4(1), CTLA4(1), FYN(1), GRAP2(2), IFNG(1), KRAS(2), LCK(1), LCP2(1), NCK2(1), NFAT5(4), NFATC2(1), NFKB1(1), NRAS(1), PAK1(1), PAK3(3), PAK4(1), PAK7(1), PIK3CA(6), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(1), PIK3R3(1), PLCG1(2), PPP3CC(2), PRKCQ(2), PTPRC(4), TEC(2), TNF(1), VAV1(3), VAV2(3), VAV3(1), ZAP70(5)	37426911	69	46	68	14	11	17	14	14	13	0	0.0314	1.000	1.000
493	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ADH4(2), ADH7(3), ALDH1A3(2), AOC3(1), AOX1(2), DBH(1), DCT(2), DDC(2), ESCO2(1), HEMK1(1), HPD(1), MAOB(1), PNPLA3(1), PRMT2(2), PRMT3(1), PRMT6(1), PRMT8(1), SH3GLB1(1), TAT(2), TH(1), TPO(1), TYR(2), WBSCR22(1)	21733216	33	22	33	10	6	13	5	4	5	0	0.347	1.000	1.000
494	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	CISH(2), IARS(1), IL2RG(1), INPP5D(3), JAK1(1), JAK3(2), PI3(1), PIK3CA(6), PPP1R13B(1), SERPINA4(1)	13662869	19	16	18	8	3	4	4	7	1	0	0.802	1.000	1.000
495	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	BCAR1(1), CAPN1(1), CAPN11(2), CAPN3(1), CAPN5(1), CAPN7(2), CAPN9(2), CAPNS1(1), DOCK1(2), FYN(1), ITGA10(3), ITGA2(1), ITGA2B(2), ITGA3(1), ITGA4(1), ITGA6(1), ITGA8(1), ITGA9(1), ITGAD(3), ITGAE(1), ITGAM(2), ITGAV(3), ITGB2(1), ITGB4(2), ITGB6(1), ITGB7(2), ITGB8(1), MAP2K2(1), MAP2K3(2), MAP2K6(2), MAPK10(2), MAPK6(2), MAPK7(1), MYLK2(2), PAK1(1), PAK3(3), PAK4(1), PTK2(3), RAC1(1), RAPGEF1(1), RHO(1), ROCK1(1), ROCK2(1), SHC3(1), SORBS1(1), TLN1(2), TNS1(1), VASP(1), VAV2(3), VAV3(1)	50214439	76	51	76	15	13	22	15	15	11	0	0.00905	1.000	1.000
496	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	CASP4(2), CD40LG(1), FAS(1), NFKB1(1), NGFR(1), NTRK1(3), RIPK1(2), TNF(1), TNFRSF1A(1), TRAF2(2), TRAF6(2)	16085631	17	14	17	7	6	6	2	1	2	0	0.687	1.000	1.000
497	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	53	ADORA3(2), ALG6(1), CCKBR(2), CCR3(1), CELSR1(6), CELSR2(2), CELSR3(3), CHRM2(1), CIDEB(1), EDNRA(1), EMR2(2), EMR3(1), F2R(1), GPR116(2), GPR132(1), GPR133(1), GPR135(1), GPR143(3), GPR55(1), GRM1(1), GRPR(1), LGR6(1), LPHN2(4), LPHN3(1), NTSR1(2), OR2M4(1), VN1R1(1)	24228063	45	33	45	12	10	13	8	11	3	0	0.0552	1.000	1.000
498	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	44	BRAF(1), CAB39(2), FIGF(1), IGF1(1), MAPK1(1), PIK3CA(6), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(1), PIK3R3(1), PRKAA2(4), RICTOR(3), RPS6KA1(1), TSC1(1), TSC2(4), ULK1(2), ULK2(2), ULK3(1), VEGFC(1)	19864903	37	26	36	11	5	12	5	7	7	1	0.383	1.000	1.000
499	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	85	ABL1(2), ABL2(1), BRAF(1), BTC(1), CAMK2B(1), CAMK2G(1), CBLB(2), CBLC(1), CDKN1A(2), EGF(4), EGFR(2), ERBB4(4), GAB1(1), KRAS(2), MAP2K2(1), MAP2K4(2), MAP2K7(2), MAPK1(1), MAPK10(2), MYC(3), NCK2(1), NRAS(1), NRG2(1), NRG3(1), PAK1(1), PAK3(3), PAK4(1), PAK7(1), PIK3CA(6), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(1), PIK3R3(1), PLCG1(2), PRKCA(1), PRKCG(1), PTK2(3), SHC3(1), SHC4(2), STAT5A(1)	38209609	69	50	68	17	12	15	13	13	16	0	0.133	1.000	1.000
500	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	69	KDR(4), KRAS(2), MAP2K2(1), MAPK1(1), MAPK11(1), NFAT5(4), NFATC2(1), NOS3(2), NRAS(1), PIK3CA(6), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(1), PIK3R3(1), PLA2G12B(1), PLA2G2D(1), PLA2G4A(1), PLCG1(2), PPP3CC(2), PRKCA(1), PRKCG(1), PTGS2(1), PTK2(3), RAC1(1), SPHK2(2)	26832461	45	37	44	13	5	5	11	12	12	0	0.500	1.000	1.000
501	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	63	BLNK(2), BTK(1), CARD11(3), CD22(1), CD81(1), CR2(2), FCGR2B(1), INPP5D(3), KRAS(2), LILRB3(1), LYN(1), NFAT5(4), NFATC2(1), NFKB1(1), NRAS(1), PIK3CA(6), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(1), PIK3R3(1), PPP3CC(2), RAC1(1), SYK(1), VAV1(3), VAV2(3), VAV3(1)	27423399	48	32	47	13	6	13	10	8	11	0	0.226	1.000	1.000
502	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH4(2), ADH7(3), AGK(1), AGPAT6(2), ALDH1A3(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), CEL(3), DGKB(1), DGKD(2), DGKE(1), DGKG(3), DGKH(2), GK2(2), GLA(1), GPAM(1), LCT(4), LIPA(1), LIPC(3), LIPF(1), LPL(2), PNLIPRP1(1), PNPLA3(1), PPAP2A(1), PPAP2C(1)	21879405	44	33	43	14	5	9	12	9	9	0	0.508	1.000	1.000
503	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	85	BRAF(1), MAP2K2(1), MAP2K3(2), MAP2K4(2), MAP2K5(1), MAP2K6(2), MAP2K7(2), MAP3K11(1), MAP3K13(1), MAP3K5(4), MAP3K6(2), MAP3K7(1), MAP3K9(2), MAP4K1(3), MAP4K4(1), MAP4K5(1), MAPK1(1), MAPK10(2), MAPK11(1), MAPK6(2), MAPK7(1), MEF2B(2), MEF2C(1), MYC(3), NFKB1(1), PAK1(1), RAC1(1), RELA(2), RIPK1(2), RPS6KA1(1), SP1(2), STAT1(2), TGFB1(1), TGFBR1(1), TRAF2(2)	36339251	56	35	56	13	9	18	9	12	8	0	0.0499	1.000	1.000
504	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	109	ACTN1(1), ACTN4(3), ARHGAP5(1), BCAR1(1), CDH5(1), CLDN1(1), CLDN10(1), CLDN15(1), CLDN2(1), CLDN4(1), CLDN6(1), CLDN8(1), CTNNA1(2), CTNNA2(5), CTNNA3(3), CTNND1(3), CYBB(1), EZR(1), F11R(4), ITGA4(1), ITGAM(2), ITGB2(1), MAPK11(1), MLLT4(1), MMP9(1), NCF4(1), NOX1(1), OCLN(1), PIK3CA(6), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(1), PIK3R3(1), PLCG1(2), PRKCA(1), PRKCG(1), PTK2(3), PTK2B(2), PTPN11(3), RAC1(1), RAP1A(1), RAPGEF4(1), ROCK1(1), ROCK2(1), SIPA1(1), TXK(1), VASP(1), VAV1(3), VAV2(3), VAV3(1), VCAM1(1)	46132761	83	52	82	18	14	20	14	21	14	0	0.0214	1.000	1.000
505	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	50	AKR1C3(1), ALOX12(2), ALOX12B(3), ALOX15(1), ALOX15B(1), ALOX5(1), CBR3(1), CYP2C18(3), CYP2C19(2), CYP2C9(2), CYP2E1(2), CYP2J2(2), CYP4A11(1), CYP4F2(2), GGT1(1), GPX5(2), PLA2G12B(1), PLA2G2D(1), PLA2G4A(1), PTGIS(1), PTGS2(1), TBXAS1(1)	14887032	33	27	33	11	6	7	12	3	5	0	0.418	1.000	1.000
506	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AMY2B(4), ENPP3(2), GAA(1), GBE1(4), GUSB(2), GYS2(1), HK2(2), MGAM(5), PGM1(1), PYGB(1), PYGM(2), RNPC3(1), SI(4), UGDH(1), UGT1A10(1), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT2B15(1)	21353980	37	26	37	10	10	13	3	5	6	0	0.164	1.000	1.000
507	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	89	ACVR1B(1), ACVR2B(1), AMHR2(1), BMP5(1), BMP6(2), BMPR2(1), CHRD(2), COMP(2), CREBBP(4), CUL1(3), E2F4(2), EP300(2), FST(1), ID3(1), ID4(1), IFNG(1), INHBA(1), LTBP1(4), MAPK1(1), MYC(3), PPP2R1A(1), PPP2R1B(1), PPP2R2A(1), PPP2R2B(1), PPP2R2C(1), ROCK1(1), ROCK2(1), SMAD3(1), SMURF2(1), SP1(2), TFDP1(1), TGFB1(1), TGFBR1(1), TGFBR2(1), THBS1(1), THBS3(2), TNF(1), ZFYVE9(4)	36197643	58	37	58	16	10	13	9	13	13	0	0.272	1.000	1.000
508	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	84	ANPEP(1), CD1A(1), CD1C(1), CD22(1), CD33(1), CD34(1), CD3G(1), CR1(3), CR2(2), CSF1R(2), CSF2RA(1), CSF3R(1), EPO(1), FCER2(2), HLA-DRB1(1), HLA-DRB5(1), IL1A(1), IL5RA(2), IL6R(1), IL7R(1), IL9R(2), ITGA1(1), ITGA2(1), ITGA2B(2), ITGA3(1), ITGA4(1), ITGA6(1), ITGAM(2), KIT(4), MME(2), MS4A1(1), TNF(1), TPO(1)	30408193	46	30	46	13	6	12	11	7	9	1	0.275	1.000	1.000
509	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	126	BRAF(1), CD48(1), FAS(1), FCGR3A(2), FYN(1), HLA-E(1), IFNA1(1), IFNA14(1), IFNA16(1), IFNA17(1), IFNA8(1), IFNAR1(1), IFNG(1), ITGB2(1), KIR3DL1(2), KIR3DL2(1), KLRC3(1), KRAS(2), LCK(1), LCP2(1), MAP2K2(1), MAPK1(1), MICA(1), NFAT5(4), NFATC2(1), NRAS(1), PAK1(1), PIK3CA(6), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(1), PIK3R3(1), PLCG1(2), PPP3CC(2), PRKCA(1), PRKCG(1), PTK2B(2), PTPN11(3), RAC1(1), SHC3(1), SHC4(2), SYK(1), TNF(1), TNFRSF10D(1), ULBP1(1), VAV1(3), VAV2(3), VAV3(1), ZAP70(5)	41909183	76	53	75	21	12	20	10	19	15	0	0.183	1.000	1.000
510	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	73	CDIPT(1), CDS1(1), DGKB(1), DGKD(2), DGKE(1), DGKG(3), DGKH(2), FN3K(1), INPP1(1), INPP4B(1), INPP5A(1), INPP5B(2), INPP5D(3), INPPL1(1), ITPK1(2), ITPKA(1), ITPR1(4), ITPR2(6), ITPR3(2), PI4KA(3), PI4KB(1), PIK3C2G(7), PIK3CA(6), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(1), PIK3R3(1), PIP5K1A(1), PIP5K1B(1), PLCB1(4), PLCB2(1), PLCB3(1), PLCB4(3), PLCD3(1), PLCE1(4), PLCG1(2), PLCZ1(1), PRKCA(1), PRKCG(1), PTEN(8), SYNJ1(1), SYNJ2(1)	46731979	90	59	88	24	18	22	10	21	19	0	0.114	1.000	1.000
511	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	152	CBLB(2), CBLC(1), CCND1(1), CISH(2), CNTFR(1), CREBBP(4), CSF2RA(1), CSF2RB(2), CSF3R(1), EP300(2), EPO(1), IFNA1(1), IFNA14(1), IFNA16(1), IFNA17(1), IFNA8(1), IFNAR1(1), IFNG(1), IFNW1(2), IL10RA(2), IL12RB1(1), IL12RB2(3), IL13RA2(1), IL20RA(1), IL21R(1), IL22RA1(1), IL23A(1), IL23R(1), IL26(1), IL2RB(4), IL2RG(1), IL5RA(2), IL6R(1), IL7R(1), IL9R(2), IRF9(1), JAK1(1), JAK3(2), LIFR(1), MYC(3), PIAS1(2), PIK3CA(6), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(1), PIK3R3(1), PIM1(1), PRLR(4), PTPN11(3), SOCS2(1), SPRED1(2), SPRED2(1), SPRY3(2), STAT1(2), STAT4(1), STAT5A(1), TPO(1)	53770951	92	56	91	22	14	24	18	21	15	0	0.0662	1.000	1.000
512	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP5(1), BMP6(2), BTRC(1), CSNK1G3(1), GLI1(4), GLI2(1), GLI3(1), HHIP(2), LRP2(12), PRKACA(2), PTCH1(1), PTCH2(1), STK36(1), SUFU(2), WNT10B(1), WNT2(1), WNT5A(1), WNT7B(1), WNT8A(1), WNT8B(1), ZIC2(1)	22010247	39	30	39	13	5	8	8	11	7	0	0.378	1.000	1.000
513	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AMY2B(4), ASCC3(2), ATP13A2(1), DDX18(2), DDX4(1), DDX41(1), DDX50(1), DDX51(1), DDX52(1), DDX56(1), ENPP3(2), EP400(2), G6PC2(1), GAA(1), GBA(1), GBE1(4), GUSB(2), GYS2(1), HK2(2), IFIH1(1), MGAM(5), MOV10L1(1), PGM1(1), PYGB(1), PYGM(2), RAD54B(1), RAD54L(1), RUVBL2(2), SETX(3), SI(4), SMARCA2(2), SMARCA5(2), UGDH(1), UGP2(1), UGT1A10(1), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT2A3(1), UGT2B11(3), UGT2B15(1), UGT2B17(2)	46113506	71	49	71	16	15	23	12	10	11	0	0.0295	1.000	1.000
514	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	75	ACTB(1), ACTN1(1), ACTN4(3), ACVR1B(1), BAIAP2(2), CREBBP(4), CTNNA1(2), CTNNA2(5), CTNNA3(3), CTNND1(3), EGFR(2), EP300(2), FARP2(1), FER(1), FGFR1(3), FYN(1), IGF1R(1), IQGAP1(4), LMO7(3), MAP3K7(1), MAPK1(1), MET(4), MLLT4(1), PTPRB(4), PTPRF(2), PTPRJ(1), PTPRM(4), PVRL2(1), PVRL3(2), RAC1(1), SMAD3(1), SNAI1(1), SORBS1(1), SSX2IP(1), TCF7L1(1), TCF7L2(1), TGFBR1(1), TGFBR2(1), TJP1(1), WASF3(2), YES1(1)	44285300	77	45	77	20	10	31	13	12	11	0	0.0467	1.000	1.000
515	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	248	ACVR1B(1), ARRB1(1), BRAF(1), CACNA1A(7), CACNA1B(4), CACNA1C(4), CACNA1D(2), CACNA1E(4), CACNA1F(5), CACNA1G(3), CACNA1H(4), CACNA1I(3), CACNA1S(5), CACNA2D1(2), CACNA2D3(1), CACNA2D4(1), CACNB1(1), CACNB2(1), CACNB4(1), CACNG3(2), CACNG5(2), CACNG6(1), CACNG8(1), CDC25B(1), DUSP5(1), DUSP7(2), DUSP9(1), EGF(4), EGFR(2), FAS(1), FGF13(3), FGF17(1), FGF18(1), FGF23(1), FGF3(2), FGFR1(3), FGFR3(1), FGFR4(2), FLNA(4), FLNB(2), FLNC(3), IL1A(1), KRAS(2), MAP2K2(1), MAP2K3(2), MAP2K4(2), MAP2K5(1), MAP2K6(2), MAP2K7(2), MAP3K13(1), MAP3K5(4), MAP3K6(2), MAP3K7(1), MAP4K1(3), MAP4K4(1), MAPK1(1), MAPK10(2), MAPK11(1), MAPK7(1), MAPK8IP3(2), MAPT(1), MEF2C(1), MYC(3), NF1(10), NFATC2(1), NFKB1(1), NRAS(1), NTRK1(3), NTRK2(2), PAK1(1), PDGFB(1), PDGFRA(1), PDGFRB(2), PLA2G12B(1), PLA2G2D(1), PLA2G4A(1), PPP3CC(2), PPP5C(1), PRKACA(2), PRKCA(1), PRKCG(1), PTPN5(2), PTPN7(1), PTPRR(2), RAC1(1), RAP1A(1), RAPGEF2(1), RASA1(2), RASGRF1(4), RASGRF2(2), RPS6KA1(1), RRAS(1), SRF(1), TAOK1(2), TAOK2(1), TGFB1(1), TGFBR1(1), TGFBR2(1), TNF(1), TNFRSF1A(1), TP53(90), TRAF2(2), TRAF6(2), ZAK(1)	109443143	284	145	268	76	48	63	45	50	77	1	0.00756	1.000	1.000
516	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	192	ACTB(1), ACTN1(1), ACTN4(3), ARHGAP5(1), BCAR1(1), BRAF(1), CCND1(1), CHAD(1), COL11A1(3), COL11A2(7), COL1A1(2), COL1A2(1), COL4A1(5), COL4A2(2), COL4A4(4), COL4A6(4), COL5A2(1), COL5A3(9), COL6A1(2), COL6A3(4), COL6A6(3), COMP(2), DIAPH1(2), DOCK1(2), EGF(4), EGFR(2), FARP2(1), FIGF(1), FLNA(4), FLNB(2), FLNC(3), FLT1(1), FN1(3), FYN(1), HGF(1), IGF1(1), IGF1R(1), ITGA1(1), ITGA10(3), ITGA2(1), ITGA2B(2), ITGA3(1), ITGA4(1), ITGA6(1), ITGA8(1), ITGA9(1), ITGAV(3), ITGB4(2), ITGB6(1), ITGB7(2), ITGB8(1), KDR(4), LAMA1(4), LAMA2(5), LAMA3(4), LAMA4(2), LAMA5(5), LAMB1(2), LAMB2(1), LAMB3(2), LAMB4(1), LAMC1(3), LAMC2(1), LAMC3(2), MAPK1(1), MAPK10(2), MET(4), MYLK(3), MYLK2(2), PAK1(1), PAK3(3), PAK4(1), PAK7(1), PARVG(1), PDGFB(1), PDGFD(1), PDGFRA(1), PDGFRB(2), PIK3CA(6), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(1), PIK3R3(1), PPP1R12A(1), PRKCA(1), PRKCG(1), PTEN(8), PTK2(3), RAC1(1), RAP1A(1), RAPGEF1(1), RELN(6), ROCK1(1), ROCK2(1), SHC3(1), SHC4(2), THBS1(1), THBS3(2), TLN1(2), TLN2(5), TNC(4), TNN(2), TNR(7), TNXB(6), VASP(1), VAV1(3), VAV2(3), VAV3(1), VEGFC(1), VTN(2), VWF(4)	138491002	253	123	252	73	39	80	38	55	40	1	0.0121	1.000	1.000
517	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	168	ADCY1(1), ADCY2(2), ADCY3(1), ADCY7(1), ADCY8(2), ADCY9(1), ADORA2A(1), AGTR1(1), ATP2A1(1), ATP2A2(1), ATP2A3(2), ATP2B1(3), ATP2B2(2), ATP2B4(1), BDKRB1(1), BST1(2), CACNA1A(7), CACNA1B(4), CACNA1C(4), CACNA1D(2), CACNA1E(4), CACNA1F(5), CACNA1G(3), CACNA1H(4), CACNA1I(3), CACNA1S(5), CAMK2B(1), CAMK2G(1), CCKAR(1), CCKBR(2), CHRM1(1), CHRM2(1), CHRM5(1), CHRNA7(1), CYSLTR2(2), DRD1(1), EDNRA(1), EGFR(2), ERBB4(4), F2R(1), GNA11(1), GNAL(1), GNAS(2), GRIN1(2), GRIN2A(2), GRIN2D(1), GRM1(1), GRM5(4), GRPR(1), HTR2A(1), HTR4(1), HTR6(1), ITPKA(1), ITPR1(4), ITPR2(6), ITPR3(2), LHCGR(5), MYLK(3), MYLK2(2), NOS1(6), NOS3(2), NTSR1(2), P2RX7(1), PDE1A(2), PDE1B(2), PDE1C(4), PDGFRA(1), PDGFRB(2), PHKA1(3), PHKA2(2), PHKB(2), PLCB1(4), PLCB2(1), PLCB3(1), PLCB4(3), PLCD3(1), PLCE1(4), PLCG1(2), PLCZ1(1), PPP3CC(2), PRKACA(2), PRKCA(1), PRKCG(1), PTAFR(1), PTK2B(2), RYR1(15), RYR2(15), RYR3(6), SLC8A1(2), SLC8A2(2), SLC8A3(5), SPHK2(2), TACR1(2), TRHR(1), TRPC1(1), VDAC1(1)	102378844	232	114	230	83	51	64	40	35	41	1	0.0551	1.000	1.000
518	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	136	ACTB(1), CHAD(1), COL11A1(3), COL11A2(7), COL17A1(3), COL1A1(2), COL1A2(1), COL4A1(5), COL4A2(2), COL4A4(4), COL4A6(4), COL5A2(1), COL5A3(9), COL6A1(2), COL6A3(4), COL6A6(3), COMP(2), DSC3(1), DSG2(2), DSG3(1), DSG4(2), FN1(3), GJA4(1), GJA5(1), GJA8(1), GJB1(1), GJB2(1), GJD2(2), INA(1), ITGA6(1), ITGB4(2), KRT1(1), KRT10(2), KRT12(1), KRT14(3), KRT16(1), KRT18(1), KRT20(1), KRT23(1), KRT27(1), KRT33B(1), KRT36(1), KRT4(3), KRT5(3), KRT6A(1), KRT6B(1), KRT6C(1), KRT71(1), KRT72(1), KRT73(1), KRT74(1), KRT75(2), KRT76(1), KRT77(2), KRT78(1), KRT79(1), KRT8(1), KRT81(1), KRT82(1), KRT84(1), KRT85(1), KRT86(1), LAMA1(4), LAMA2(5), LAMA3(4), LAMA4(2), LAMA5(5), LAMB1(2), LAMB2(1), LAMB3(2), LAMB4(1), LAMC1(3), LAMC2(1), LAMC3(2), LMNB1(1), NES(2), RELN(6), THBS1(1), THBS3(2), TNC(4), TNN(2), TNR(7), TNXB(6), VTN(2), VWF(4)	92753951	183	92	183	63	37	65	21	31	27	2	0.0888	1.000	1.000
519	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	237	ADORA2A(1), ADORA3(2), ADRA2B(1), ADRA2C(1), AGTR1(1), AGTR2(1), BDKRB1(1), C3AR1(1), CALCR(3), CALCRL(1), CCKAR(1), CCKBR(2), CHRM1(1), CHRM2(1), CHRM4(1), CHRM5(1), CNR1(3), CRHR2(4), CTSG(1), CYSLTR2(2), DRD1(1), DRD2(1), DRD3(2), EDNRA(1), F2R(1), GABRA1(1), GABRA2(2), GABRA4(1), GABRA5(2), GABRA6(2), GABRB2(1), GABRD(1), GABRE(1), GABRG1(2), GABRG3(1), GABRP(1), GABRR1(5), GHSR(2), GLP1R(2), GLP2R(2), GLRA1(3), GLRA3(2), GPR156(3), GPR50(2), GPR63(1), GRIA1(6), GRIA4(1), GRID1(1), GRID2(3), GRIK1(2), GRIK2(1), GRIK3(4), GRIK4(2), GRIK5(2), GRIN1(2), GRIN2A(2), GRIN2D(1), GRIN3A(4), GRIN3B(1), GRM1(1), GRM3(5), GRM4(1), GRM5(4), GRM7(2), GRM8(2), GRPR(1), HCRTR2(1), HRH3(1), HTR1A(1), HTR1D(2), HTR2A(1), HTR4(1), HTR6(1), LHCGR(5), MTNR1A(1), NMUR2(2), NPBWR2(1), NPFFR2(1), NTSR1(2), OPRM1(1), P2RX7(1), P2RY10(1), P2RY2(1), P2RY4(1), P2RY6(1), PRLHR(4), PRLR(4), PRSS1(1), PTAFR(1), PTGER2(2), PTGIR(1), PTH2R(2), RXFP1(1), RXFP2(3), SCTR(3), SSTR3(1), TAAR2(1), TAAR6(1), TACR1(2), THRA(1), TRHR(1), VIPR1(2)	80343925	178	92	177	61	39	49	36	34	20	0	0.0527	1.000	1.000
520	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	202	ACTN1(1), ACTN4(3), APC(5), ARHGEF1(1), ARHGEF4(1), ARHGEF6(2), ARHGEF7(1), ARPC1B(1), BAIAP2(2), BCAR1(1), BDKRB1(1), BRAF(1), CHRM1(1), CHRM2(1), CHRM4(1), CHRM5(1), CYFIP1(1), CYFIP2(3), DIAPH1(2), DIAPH2(3), DOCK1(2), EGF(4), EGFR(2), EZR(1), F2R(1), FGD3(1), FGF13(3), FGF17(1), FGF18(1), FGF23(1), FGF3(2), FGFR1(3), FGFR3(1), FGFR4(2), FN1(3), IQGAP1(4), IQGAP3(2), ITGA1(1), ITGA10(3), ITGA2(1), ITGA2B(2), ITGA3(1), ITGA4(1), ITGA6(1), ITGA8(1), ITGA9(1), ITGAD(3), ITGAE(1), ITGAM(2), ITGAV(3), ITGB2(1), ITGB4(2), ITGB6(1), ITGB7(2), ITGB8(1), KRAS(2), LIMK1(2), MAP2K2(1), MAPK1(1), MYH10(3), MYH14(4), MYH9(3), MYLK(3), MYLK2(2), NCKAP1(2), NCKAP1L(1), NRAS(1), PAK1(1), PAK3(3), PAK4(1), PAK7(1), PDGFB(1), PDGFRA(1), PDGFRB(2), PFN2(1), PIK3CA(6), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(1), PIK3R3(1), PIP5K1A(1), PIP5K1B(1), PPP1R12A(1), PPP1R12B(1), PTK2(3), RAC1(1), RDX(1), ROCK1(1), ROCK2(1), RRAS(1), SCIN(1), SSH1(2), SSH3(2), TIAM1(1), VAV1(3), VAV2(3), VAV3(1)	103506601	168	91	167	46	27	47	35	29	30	0	0.0263	1.000	1.000
521	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	130	ACTB(1), ACTN1(1), ACTN4(3), ASH1L(2), CDK4(1), CGN(1), CLDN1(1), CLDN10(1), CLDN15(1), CLDN2(1), CLDN4(1), CLDN6(1), CLDN8(1), CTNNA1(2), CTNNA2(5), CTNNA3(3), CTTN(3), EPB41(1), EPB41L1(1), EPB41L3(1), F11R(4), HCLS1(2), KRAS(2), LLGL2(1), MAGI1(3), MAGI2(3), MAGI3(1), MLLT4(1), MPDZ(2), MYH1(4), MYH10(3), MYH11(4), MYH13(2), MYH14(4), MYH15(3), MYH2(6), MYH3(4), MYH4(6), MYH6(1), MYH7(7), MYH7B(4), MYH9(3), NRAS(1), OCLN(1), PARD6B(1), PPP2R1A(1), PPP2R1B(1), PPP2R2A(1), PPP2R2B(1), PPP2R2C(1), PPP2R3A(1), PPP2R3B(1), PRKCA(1), PRKCE(2), PRKCG(1), PRKCH(1), PRKCI(1), PRKCQ(2), PTEN(8), RRAS(1), SPTAN1(3), SYMPK(1), TJAP1(1), TJP1(1), TJP2(4), TJP3(2), YES1(1), ZAK(1)	72317177	143	89	143	40	23	31	34	26	29	0	0.155	1.000	1.000
522	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	127	ABL1(2), DCC(7), DPYSL5(2), EFNB3(1), EPHA1(1), EPHA2(1), EPHA3(3), EPHA4(2), EPHA5(4), EPHA6(3), EPHA7(3), EPHA8(4), EPHB1(2), EPHB2(1), EPHB4(1), EPHB6(1), FES(1), FYN(1), KRAS(2), L1CAM(1), LIMK1(2), LRRC4C(1), MAPK1(1), MET(4), NCK2(1), NFAT5(4), NFATC2(1), NRAS(1), NTN1(1), NTN4(1), PAK1(1), PAK3(3), PAK4(1), PAK7(1), PLXNA1(2), PLXNA2(3), PLXNA3(1), PLXNB1(2), PLXNB2(1), PLXNB3(2), PPP3CC(2), PTK2(3), RAC1(1), RASA1(2), ROBO2(3), ROBO3(3), ROCK1(1), ROCK2(1), SEMA3A(2), SEMA3C(1), SEMA3D(1), SEMA4B(1), SEMA4D(2), SEMA5A(2), SEMA5B(1), SEMA6A(2), SEMA6B(1), SEMA6D(3), SLIT2(4), SLIT3(3), SRGAP1(3), SRGAP3(3), UNC5A(2), UNC5B(3), UNC5C(1), UNC5D(1)	72682540	129	85	129	46	22	30	37	24	16	0	0.469	1.000	1.000
523	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(1), CHAD(1), COL11A1(3), COL11A2(7), COL1A1(2), COL1A2(1), COL4A1(5), COL4A2(2), COL4A4(4), COL4A6(4), COL5A2(1), COL5A3(9), COL6A1(2), COL6A3(4), COL6A6(3), FN1(3), GP6(1), HMMR(1), HSPG2(4), ITGA1(1), ITGA10(3), ITGA2(1), ITGA2B(2), ITGA3(1), ITGA4(1), ITGA6(1), ITGA8(1), ITGA9(1), ITGAV(3), ITGB4(2), ITGB6(1), ITGB7(2), ITGB8(1), LAMA1(4), LAMA2(5), LAMA3(4), LAMA4(2), LAMA5(5), LAMB1(2), LAMB2(1), LAMB3(2), LAMB4(1), LAMC1(3), LAMC2(1), LAMC3(2), RELN(6), SV2A(1), SV2B(2), SV2C(3), THBS1(1), THBS3(2), TNC(4), TNN(2), TNR(7), TNXB(6), VTN(2), VWF(4)	83847342	151	83	151	50	27	45	25	28	25	1	0.185	1.000	1.000
524	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(1), ADCY2(2), ADCY3(1), ADCY5(1), ADCY7(1), ADCY8(2), ADCY9(1), ANXA6(1), ARRB1(1), ATP1A4(3), ATP1B2(1), ATP2A2(1), ATP2A3(2), ATP2B1(3), ATP2B2(2), CACNA1A(7), CACNA1B(4), CACNA1C(4), CACNA1D(2), CACNA1E(4), CACNA1S(5), CACNB1(1), CAMK2B(1), CAMK2G(1), CHRM1(1), CHRM2(1), CHRM4(1), CHRM5(1), GJA4(1), GJA5(1), GJB1(1), GJB2(1), GNA11(1), GNAZ(1), GNB2(1), GRK4(1), GRK5(1), ITPR1(4), ITPR2(6), ITPR3(2), KCNB1(1), KCNJ3(1), KCNJ5(2), PKIB(1), PLCB3(1), PRKACA(2), PRKAR2B(1), PRKCA(1), PRKCE(2), PRKCG(1), PRKCH(1), PRKCQ(2), PRKD1(1), RGS11(1), RGS17(1), RGS18(1), RGS2(1), RGS6(1), RGS7(2), RYR1(15), RYR2(15), RYR3(6), SLC8A1(2), SLC8A3(5)	71407703	144	75	143	58	28	45	27	18	26	0	0.244	1.000	1.000
525	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	251	ACVR1B(1), ACVR2B(1), AMHR2(1), BMPR2(1), CCL15(1), CCL23(1), CCL3(1), CCR1(1), CCR3(1), CCR4(1), CD40LG(1), CNTFR(1), CSF1R(2), CSF2RA(1), CSF2RB(2), CSF3R(1), CX3CL1(2), CXCL14(2), CXCL5(1), CXCR6(2), EDA2R(1), EGF(4), EGFR(2), EPO(1), FAS(1), FLT1(1), FLT4(2), HGF(1), IFNA1(1), IFNA14(1), IFNA16(1), IFNA17(1), IFNA8(1), IFNAR1(1), IFNG(1), IFNW1(2), IL10RA(2), IL12RB1(1), IL12RB2(3), IL17A(1), IL17B(1), IL17RA(2), IL18R1(1), IL1A(1), IL20RA(1), IL21R(1), IL22RA1(1), IL23A(1), IL23R(1), IL25(1), IL26(1), IL2RB(4), IL2RG(1), IL5RA(2), IL6R(1), IL7R(1), IL9R(2), INHBA(1), KDR(4), KIT(4), LIFR(1), MET(4), NGFR(1), PDGFB(1), PDGFRA(1), PDGFRB(2), PLEKHO2(1), PRLR(4), TGFB1(1), TGFBR1(1), TGFBR2(1), TNF(1), TNFRSF10D(1), TNFRSF19(1), TNFRSF1A(1), TNFRSF21(3), TNFRSF8(1), TNFRSF9(2), TNFSF15(1), TPO(1), VEGFC(1)	65830818	117	68	117	33	23	33	20	22	18	1	0.0353	1.000	1.000
526	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	131	ACACA(1), ACACB(2), BRAF(1), CBLB(2), CBLC(1), EXOC7(1), FASN(3), G6PC2(1), GYS2(1), INPP5D(3), IRS1(1), IRS4(3), KRAS(2), MAP2K2(1), MAPK1(1), MAPK10(2), NRAS(1), PDE3A(1), PDE3B(3), PFKL(2), PFKP(1), PHKA1(3), PHKA2(2), PHKB(2), PIK3CA(6), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(1), PIK3R3(1), PKLR(2), PPARGC1A(1), PPP1R3A(5), PRKAA2(4), PRKAB2(1), PRKACA(2), PRKAR2B(1), PRKCI(1), PTPRF(2), PYGB(1), PYGM(2), RAPGEF1(1), SHC3(1), SHC4(2), SLC2A4(1), SOCS2(1), SORBS1(1), SREBF1(2), TRIP10(1), TSC1(1), TSC2(4)	59646946	90	68	89	29	7	22	19	26	16	0	0.407	1.000	1.000
527	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ACTA2(2), ADCY1(1), ADCY2(2), ADCY3(1), ADCY5(1), ADCY7(1), ADCY8(2), ADCY9(1), ARRB1(1), ATP2A2(1), ATP2A3(2), CAMK2B(1), CAMK2G(1), CNN1(1), CNN2(1), CORIN(1), GBA2(3), GNB2(1), GRK4(1), GRK5(1), GUCY1A3(1), IGFBP4(1), ITPR1(4), ITPR2(6), ITPR3(2), MYLK2(2), NFKB1(1), NOS1(6), NOS3(2), PDE4B(1), PDE4D(2), PKIB(1), PLCB3(1), PLCG1(2), PRKACA(2), PRKAR2B(1), PRKCA(1), PRKCE(2), PRKCH(1), PRKCQ(2), PRKD1(1), RGS11(1), RGS17(1), RGS18(1), RGS2(1), RGS6(1), RGS7(2), RLN1(1), RYR1(15), RYR2(15), RYR3(6), SLC8A1(2), SP1(2), TNXB(6)	65525642	122	68	122	52	22	40	25	15	20	0	0.440	1.000	1.000
528	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	BRAF(1), CACNA1A(7), GNA11(1), GNAS(2), GNAZ(1), GRIA1(6), GRID2(3), GRM1(1), GRM5(4), GUCY1A3(1), GUCY1B3(2), GUCY2C(2), IGF1(1), IGF1R(1), ITPR1(4), ITPR2(6), ITPR3(2), KRAS(2), LYN(1), MAP2K2(1), MAPK1(1), NOS1(6), NOS3(2), NPR2(1), NRAS(1), PLA2G12B(1), PLA2G2D(1), PLA2G4A(1), PLCB1(4), PLCB2(1), PLCB3(1), PLCB4(3), PPP2R1A(1), PPP2R1B(1), PPP2R2A(1), PPP2R2B(1), PPP2R2C(1), PRKCA(1), PRKCG(1), PRKG1(1), PRKG2(1), RYR1(15)	41532840	96	63	95	32	23	26	16	14	17	0	0.150	1.000	1.000
529	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	129	CD22(1), CD276(1), CD34(1), CD40LG(1), CD58(1), CD86(1), CDH15(1), CDH3(1), CDH4(3), CDH5(1), CLDN1(1), CLDN10(1), CLDN15(1), CLDN2(1), CLDN4(1), CLDN6(1), CLDN8(1), CNTN2(1), CTLA4(1), F11R(4), HLA-DOA(1), HLA-DOB(1), HLA-DQA2(2), HLA-DRB1(1), HLA-DRB5(1), HLA-E(1), HLA-F(1), ITGA4(1), ITGA6(1), ITGA8(1), ITGA9(1), ITGAM(2), ITGAV(3), ITGB2(1), ITGB7(2), ITGB8(1), L1CAM(1), MADCAM1(1), MAG(2), NCAM1(1), NCAM2(2), NEGR1(2), NFASC(1), NLGN1(1), NLGN2(1), NLGN3(1), NRCAM(1), NRXN1(5), NRXN2(2), NRXN3(2), OCLN(1), PTPRC(4), PTPRF(2), PTPRM(4), PVRL2(1), PVRL3(2), SELL(1), SELP(2), SELPLG(1), SIGLEC1(1), SPN(1), VCAM1(1)	54211150	90	61	90	30	17	27	20	21	5	0	0.162	1.000	1.000
530	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	162	ADORA2A(1), ADORA3(2), ADRA2C(1), AGTR1(1), AGTR2(1), BDKRB1(1), C3AR1(1), CCKAR(1), CCKBR(2), CCR1(1), CCR3(1), CCR4(1), CHRM1(1), CHRM2(1), CHRM4(1), CHRM5(1), CMKLR1(1), CNR1(3), DRD1(1), DRD2(1), DRD3(2), EDNRA(1), F2R(1), GHSR(2), GPR37(2), GPR37L1(1), GPR50(2), GPR63(1), GRPR(1), HCRTR2(1), HRH3(1), HTR1A(1), HTR1D(2), HTR2A(1), HTR4(1), HTR6(1), LHCGR(5), MTNR1A(1), NMUR2(2), NTSR1(2), OPN1SW(1), OPRM1(1), OR10A5(1), OR11A1(2), OR1C1(2), OR1F1(1), OR2H1(2), OR5V1(3), OR7A5(1), OR7C1(1), OR8B8(1), P2RY10(1), P2RY12(1), P2RY2(1), P2RY6(1), PTAFR(1), PTGER2(2), PTGIR(1), RGR(1), RHO(1), SSTR3(1), SUCNR1(1), TRHR(1)	43013389	84	58	83	36	14	23	21	14	12	0	0.504	1.000	1.000
531	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	92	ADCY1(1), ADCY2(2), ADCY3(1), ADCY5(1), ADCY7(1), ADCY8(2), ADCY9(1), DRD1(1), DRD2(1), EGF(4), EGFR(2), GJD2(2), GNA11(1), GNAS(2), GRM1(1), GRM5(4), GUCY1A3(1), GUCY1B3(2), GUCY2C(2), HTR2A(1), ITPR1(4), ITPR2(6), ITPR3(2), KRAS(2), MAP2K2(1), MAP2K5(1), MAPK1(1), MAPK7(1), NPR2(1), NRAS(1), PDGFB(1), PDGFD(1), PDGFRA(1), PDGFRB(2), PLCB1(4), PLCB2(1), PLCB3(1), PLCB4(3), PRKACA(2), PRKCA(1), PRKCG(1), PRKG1(1), PRKG2(1), TJP1(1), TUBA3C(3), TUBA3E(1), TUBA4A(1), TUBA8(1), TUBAL3(2), TUBB2B(2), TUBB8(3)	49108820	87	54	86	40	18	26	14	20	9	0	0.724	1.000	1.000
532	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	67	A2M(3), BDKRB1(1), C1QA(1), C1QB(1), C1S(1), C3(4), C3AR1(1), C4BPA(2), C4BPB(1), C5(2), C6(4), C7(1), C8A(1), C8B(1), C9(3), CFH(4), CR1(3), CR2(2), F11(1), F12(1), F13A1(3), F13B(1), F2R(1), F5(5), F7(1), F8(3), FGA(2), FGB(2), FGG(2), KLKB1(2), KNG1(1), MASP1(3), MASP2(1), MBL2(1), PLG(1), PROS1(1), SERPINA1(1), SERPIND1(1), SERPINF2(1), TFPI(1), VWF(4)	33220924	76	52	76	28	7	24	17	19	8	1	0.585	1.000	1.000
533	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	95	ADCY1(1), ADCY2(2), ADCY3(1), ADCY5(1), ADCY7(1), ADCY8(2), ADCY9(1), CACNA1C(4), CACNA1D(2), CACNA1F(5), CACNA1S(5), CAMK2B(1), CAMK2G(1), EGFR(2), GNA11(1), GNAS(2), GNRH2(1), ITPR1(4), ITPR2(6), ITPR3(2), KRAS(2), MAP2K2(1), MAP2K3(2), MAP2K4(2), MAP2K6(2), MAP2K7(2), MAPK1(1), MAPK10(2), MAPK11(1), MAPK7(1), NRAS(1), PLA2G12B(1), PLA2G2D(1), PLA2G4A(1), PLCB1(4), PLCB2(1), PLCB3(1), PLCB4(3), PLD1(2), PRKACA(2), PRKCA(1), PTK2B(2)	48285926	81	50	81	35	18	20	10	19	14	0	0.628	1.000	1.000
534	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	67	ADCY1(1), ADCY8(2), BRAF(1), CACNA1C(4), CAMK2B(1), CAMK2G(1), CREBBP(4), EP300(2), GRIA1(6), GRIN1(2), GRIN2A(2), GRIN2D(1), GRM1(1), GRM5(4), ITPR1(4), ITPR2(6), ITPR3(2), KRAS(2), MAP2K2(1), MAPK1(1), NRAS(1), PLCB1(4), PLCB2(1), PLCB3(1), PLCB4(3), PPP1R12A(1), PPP1R1A(2), PPP3CC(2), PRKACA(2), PRKCA(1), PRKCG(1), RAP1A(1), RPS6KA1(1)	37574800	69	48	69	24	13	16	9	19	12	0	0.376	1.000	1.000
535	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	82	ACVR1B(1), AURKB(1), BMPR2(1), CDIPT(1), CDS1(1), CLK1(1), CLK4(1), COL4A3BP(2), DGKB(1), DGKD(2), DGKE(1), DGKG(3), DGKH(2), INPP1(1), INPP4B(1), INPP5A(1), INPPL1(1), ITPKA(1), NEK1(2), PAK4(1), PIK3C2G(7), PIK3CA(6), PIK3CB(1), PIK3CG(2), PIM2(3), PLCB1(4), PLCB2(1), PLCB3(1), PLCB4(3), PLCG1(2), PRKACA(2), PRKAR2B(1), PRKCA(1), PRKCE(2), PRKCG(1), PRKCH(1), PRKCQ(2), PRKD1(1), PRKG1(1), RPS6KA1(1), TGFBR1(1), VRK1(1)	42650320	71	47	69	23	10	19	10	17	15	0	0.404	1.000	1.000
536	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA2(2), ACTN4(3), DMD(7), MYBPC2(1), MYBPC3(3), MYH3(4), MYH6(1), MYH7(7), MYL1(1), NEB(4), TNNT3(1), TTN(42)	51086978	76	47	76	39	14	20	20	8	13	1	0.980	1.000	1.000
537	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY1(1), ADCY2(2), ADCY3(1), ADCY5(1), ADCY7(1), ADCY8(2), ADCY9(1), AKAP10(1), AKAP11(3), AKAP12(2), AKAP2(1), AKAP3(1), AKAP5(1), AKAP6(3), AKAP8(1), AKAP9(2), ARHGEF1(1), GNA11(1), GNAL(1), GNAZ(1), GNB2(1), ITPR1(4), KCNJ3(1), KRAS(2), NRAS(1), PDE1A(2), PDE1B(2), PDE1C(4), PDE4A(3), PDE4B(1), PDE4C(2), PDE4D(2), PLCB3(1), PPP3CC(2), PRKACA(2), PRKAR2B(1), PRKCA(1), PRKCE(2), PRKCG(1), PRKCH(1), PRKCI(1), PRKCQ(2), PRKD1(1), PRKD3(2), RRAS(1)	42880422	71	46	71	25	10	17	13	10	20	1	0.524	1.000	1.000
538	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(2), ABCA10(1), ABCA13(8), ABCA2(1), ABCA3(2), ABCA4(2), ABCA5(2), ABCA6(1), ABCA7(2), ABCA8(2), ABCA9(5), ABCB11(2), ABCB4(3), ABCB5(5), ABCB6(1), ABCB7(1), ABCC1(1), ABCC10(2), ABCC11(1), ABCC12(4), ABCC2(2), ABCC3(5), ABCC8(4), ABCC9(1), ABCD1(1), ABCD4(1), ABCG1(2), ABCG5(1), CFTR(6)	44162436	71	45	71	30	7	24	12	15	13	0	0.413	1.000	1.000
539	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	98	ADCY1(1), ADCY2(2), ADCY3(1), ADCY5(1), ADCY7(1), ADCY8(2), ADCY9(1), ASIP(1), CAMK2B(1), CAMK2G(1), CREB3L3(1), CREBBP(4), DCT(2), DVL1(2), EP300(2), FZD2(1), FZD3(2), FZD5(1), FZD6(1), GNAS(2), KIT(4), KRAS(2), MAP2K2(1), MAPK1(1), NRAS(1), PLCB1(4), PLCB2(1), PLCB3(1), PLCB4(3), PRKACA(2), PRKCA(1), PRKCG(1), TCF7L1(1), TCF7L2(1), TYR(2), WNT10B(1), WNT2(1), WNT5A(1), WNT7B(1), WNT8A(1), WNT8B(1)	39944788	62	45	62	27	11	19	8	14	9	1	0.635	1.000	1.000
540	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADCY1(1), ADCY2(2), ADCY3(1), ADCY5(1), ADCY7(1), ADCY8(2), ADCY9(1), ADK(1), ADSL(1), ADSSL1(1), AK5(3), AK7(1), AMPD1(2), AMPD3(1), APRT(1), ENPP3(2), ENTPD1(1), ENTPD8(1), GART(1), GMPR2(1), GUCY1A3(1), GUCY1B3(2), GUCY2C(2), IMPDH2(1), NME2(1), NPR2(1), NT5E(1), PDE10A(1), PDE11A(1), PDE1A(2), PDE1C(4), PDE3B(3), PDE4A(3), PDE4B(1), PDE4C(2), PDE4D(2), PDE5A(1), PFAS(1), PKLR(2), PNPT1(2), POLD1(2), POLE(5), PPAT(1), PRIM2(1), RRM2(1)	60590743	70	42	70	29	8	18	20	12	12	0	0.699	1.000	1.000
541	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	BCR(2), BLNK(2), BTK(1), CD22(1), CD81(1), CR2(2), INPP5D(3), ITPR1(4), ITPR2(6), ITPR3(2), LYN(1), MAP4K1(3), MAPK1(1), NFATC2(1), PIK3CA(6), PIK3CD(1), PIK3R1(1), PPP1R13B(1), PPP3CC(2), PTPRC(4), SYK(1), VAV1(3)	27150574	49	40	48	19	11	6	13	8	11	0	0.743	1.000	1.000
542	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	71	ACACB(2), ACSL3(1), ACSL4(2), ACSL6(3), ADIPOR1(1), CAMKK1(2), CPT1A(1), CPT1B(1), G6PC2(1), IRS1(1), IRS4(3), JAK1(1), JAK3(2), MAPK10(2), NFKB1(1), PPARA(1), PPARGC1A(1), PRKAA2(4), PRKAB2(1), PRKCQ(2), PTPN11(3), RELA(2), RXRA(1), RXRG(1), SLC2A4(1), TNF(1), TNFRSF1A(1), TRAF2(2)	30727478	45	37	45	20	12	9	12	9	3	0	0.742	1.000	1.000
543	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADCY1(1), ADCY2(2), ADCY3(1), ADCY5(1), ADCY7(1), ADCY8(2), ADK(1), ADSL(1), AK5(3), AMPD1(2), AMPD3(1), APRT(1), ATP5B(1), ATP5C1(1), ATP5J2(1), ENPP3(2), ENTPD1(1), GART(1), GUCY1A3(1), GUCY1B3(2), GUCY2C(2), IMPDH2(1), NME2(1), NPR2(1), NT5E(1), PDE1A(2), PDE4A(3), PDE4B(1), PDE4C(2), PDE4D(2), PDE5A(1), PDE6B(3), PDE6C(1), PFAS(1), PKLR(2), POLD1(2), POLE(5), POLG(1), POLQ(6), POLRMT(1), PPAT(1), RRM2(1)	47510653	68	36	68	24	9	22	22	6	9	0	0.377	1.000	1.000
544	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	108	ALG1(1), ALG11(1), ALG13(1), ALG2(1), ALG6(1), ALG9(1), B3GNT2(2), B4GALT5(2), CHPF(1), CHST1(2), CHST11(1), CHST14(1), CHST3(1), CHST4(1), EXTL3(2), FUT8(1), GALNT10(1), GALNT13(1), GALNT14(3), GALNT3(1), GALNT5(1), GALNT7(1), GALNT8(2), GALNTL5(1), HS3ST1(1), HS3ST3A1(1), HS3ST3B1(1), HS3ST5(2), HS6ST1(1), MAN1A1(3), MAN1B1(1), MAN1C1(2), MGAT3(1), MGAT5B(2), NDST3(3), NDST4(3), OGT(1), RPN2(2), ST6GALNAC1(1), WBSCR17(2), XYLT2(2)	40665318	60	35	60	28	8	25	10	8	8	1	0.647	1.000	1.000
545	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	66	ATP6AP1(2), ATP6V0A4(1), ATP6V1A(2), ATP6V1E1(1), EGFR(2), F11R(4), LYN(1), MAP2K4(2), MAPK10(2), MAPK11(1), MET(4), NFKB1(1), NOD1(1), PAK1(1), PLCG1(2), PTPN11(3), PTPRZ1(5), RAC1(1), RELA(2), TCIRG1(1), TJP1(1)	25937187	40	32	40	14	6	11	7	7	9	0	0.474	1.000	1.000
546	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	57	ASH1L(2), CTCFL(2), EED(1), EHMT2(1), HCFC1(4), MEN1(1), OGT(1), PAXIP1(5), PRDM2(3), PRDM6(1), PRDM9(4), PRMT6(1), PRMT8(1), SATB1(2), SETD1A(3), SETD1B(3), SETD2(2), SETD8(1), SUV39H1(1), SUZ12(2), WHSC1(3)	46212148	44	31	44	18	4	20	6	4	10	0	0.757	1.000	1.000
547	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ADCY8(2), CACNA1A(7), CACNA1B(4), GNAS(2), GRM4(1), ITPR3(2), KCNB1(1), PDE1A(2), PLCB2(1), PRKACA(2), SCNN1B(1), SCNN1G(3), TAS1R1(2), TAS1R2(1), TAS1R3(1), TAS2R39(1), TAS2R40(1), TAS2R5(1), TAS2R7(1), TAS2R9(1), TRPM5(4)	21449520	41	29	40	23	11	10	7	6	7	0	0.744	1.000	1.000
548	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACADL(1), ACOX2(1), ACSL3(1), ACSL4(2), ACSL6(3), ANGPTL4(1), APOA5(1), CPT1A(1), CPT1B(1), CYP27A1(1), CYP4A11(1), CYP8B1(1), FABP4(1), FABP7(1), FADS2(1), GK2(2), HMGCS2(1), LPL(2), ME1(1), MMP1(2), PLTP(1), PPARA(1), RXRA(1), RXRG(1), SLC27A4(1), SLC27A5(1), SLC27A6(1), SORBS1(1)	23947823	34	28	34	20	7	7	8	8	4	0	0.965	1.000	1.000
549	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CTLA4(1), DTYMK(1), EPHB2(1), GRAP2(2), ITPKA(1), LCK(1), LCP2(1), MAPK1(1), NFAT5(4), NFKB1(1), NFKBIL1(1), PAK1(1), PAK3(3), PAK4(1), PAK7(1), PLCG1(2), PTPRC(4), VAV1(3), ZAP70(5)	21031784	35	28	35	12	7	11	4	7	6	0	0.489	1.000	1.000
550	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(1), AKR1D1(2), ARSE(1), CYP11B1(3), CYP11B2(1), CYP19A1(1), HEMK1(1), HSD11B1(1), HSD17B1(1), HSD17B12(1), HSD17B2(1), HSD3B1(1), PRMT2(2), PRMT3(1), PRMT6(1), PRMT8(1), SULT1E1(1), SULT2A1(1), UGT1A10(1), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT2A3(1), UGT2B11(3), UGT2B15(1), UGT2B17(2), WBSCR22(1)	18416833	35	27	35	17	7	7	3	10	8	0	0.929	1.000	1.000
551	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	BCR(2), BLNK(2), BTK(1), EPHB2(1), ITPKA(1), LYN(1), MAP2K2(1), MAPK1(1), NFAT5(4), NFKB1(1), NFKBIL1(1), PI3(1), PIK3CA(6), PIK3CD(1), PIK3R1(1), PPP1R13B(1), SERPINA4(1), SYK(1), VAV1(3)	19663501	31	27	30	13	8	3	5	7	8	0	0.834	1.000	1.000
552	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	ACAT1(1), ALDH1A2(1), ALDH1A3(2), ALDH2(1), ALDH9A1(1), AOC3(1), AOX1(2), CYP19A1(1), CYP1A2(2), CYP2A13(1), CYP2A6(1), CYP2C18(3), CYP2C19(2), CYP2C9(2), CYP2E1(2), CYP2F1(2), CYP2J2(2), CYP3A4(2), CYP3A7(1), CYP4B1(1), DDC(2), KYNU(2), MAOB(1), WARS(1), WARS2(1)	20431003	38	27	38	15	8	11	7	6	6	0	0.519	1.000	1.000
553	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	ACAT1(1), ALDH1A3(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), AOC3(1), AOX1(2), CYP1A2(2), DDC(2), HEMK1(1), HSD17B4(1), INMT(1), KYNU(2), MAOB(1), OGDHL(3), PRMT2(2), PRMT3(1), PRMT6(1), PRMT8(1), TPH2(3), WARS(1), WARS2(1), WBSCR22(1)	22396284	33	25	33	14	7	11	3	7	5	0	0.672	1.000	1.000
554	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(5), AXIN1(1), CCND1(1), DVL1(2), FZD2(1), FZD3(2), FZD5(1), FZD6(1), MAPK10(2), MYC(3), PPP2R5C(2), PPP2R5E(1), PRKCA(1), PRKCE(2), PRKCG(1), PRKCH(1), PRKCI(1), PRKCQ(2), PRKD1(1), RAC1(1), WNT10B(1), WNT2(1), WNT5A(1), WNT7B(1)	21786742	36	25	36	14	6	10	2	5	13	0	0.514	1.000	1.000
555	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	CHRM1(1), FLT1(1), FLT4(2), KDR(4), NOS3(2), PDE3A(1), PDE3B(3), PRKAR2B(1), PRKG1(1), PRKG2(1), RYR2(15), SYT1(1)	15294532	33	24	33	15	3	8	3	13	6	0	0.776	1.000	1.000
556	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(2), AR(4), ESR2(2), ESRRA(1), HNF4A(2), NR0B1(2), NR1D2(1), NR1I3(1), NR2E1(1), PPARA(1), RARA(1), RARB(3), RORC(1), RXRA(1), RXRG(1), THRA(1)	15369857	25	24	24	12	4	4	7	5	5	0	0.886	1.000	1.000
557	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	49	CDKN2A(1), INPPL1(1), IRS1(1), IRS4(3), LNPEP(2), MAPK1(1), PIK3CA(6), PIK3CD(1), PIK3R1(1), PTEN(8), RPS6KA1(1), SLC2A4(1), SORBS1(1), YWHAE(1)	21492460	29	24	28	11	2	4	5	10	8	0	0.793	1.000	1.000
558	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	AGMAT(1), ALDH1A2(1), ALDH1A3(2), ALDH2(1), ALDH9A1(1), AOC3(1), ARG2(2), CPS1(1), MAOB(1), NOS1(6), NOS3(2), P4HA2(1), P4HA3(1), PYCR1(2), RARS(2)	16459419	25	23	25	10	5	7	7	2	4	0	0.499	1.000	1.000
559	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F11(1), F12(1), F13B(1), F5(5), F7(1), F8(3), FGA(2), FGB(2), FGG(2), PLG(1), SERPINF2(1), VWF(4)	12796457	24	23	24	14	2	7	5	7	2	1	0.955	1.000	1.000
560	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AASDHPPT(1), AASS(1), ACAT1(1), AKR1B10(1), ALDH1A3(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), BBOX1(2), EHMT2(1), HSD17B4(1), OGDHL(3), PLOD2(2), PLOD3(1), SETD1A(3), SUV39H1(1), TMLHE(1)	21296603	24	23	24	13	2	6	5	5	6	0	0.886	1.000	1.000
561	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CLK4(1), CPSF1(1), CPSF3(1), DDX1(1), DHX38(1), DHX8(2), DICER1(3), DNAJC8(1), NUDT21(1), NXF1(1), PABPN1(1), PRPF4B(1), PRPF8(4), PTBP1(1), RBM17(1), RNMT(1), SF3A3(1), SF3B1(3), SF3B2(1), SNRPB2(1), SNRPE(1), SRPK1(2), SRPK2(2), SRRM1(2), SUPT5H(2), U2AF2(1)	39012084	38	23	38	11	3	14	5	7	9	0	0.389	1.000	1.000
562	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR1(1), AGTR2(1), ATP8A1(4), BDKRB1(1), C3AR1(1), CCKAR(1), CCKBR(2), CCR1(1), CCR3(1), CCR4(1), CXCR6(2), EDNRA(1), GHSR(2), GRPR(1), LHCGR(5), NTSR1(2), OPRM1(1), SSTR3(1), TACR1(2), TRHR(1)	18482217	32	23	31	16	5	9	5	3	10	0	0.779	1.000	1.000
563	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG2(1), ANGPTL2(2), FLNA(4), FLNC(3), GDI1(1), LIMK1(2), MYH2(6), MYLK(3), MYLK2(2), PAK1(1), PAK3(3), PAK4(1), PAK7(1), PFN2(1), RHO(1), ROCK1(1), ROCK2(1), VASP(1)	17780124	35	23	35	14	5	11	11	5	3	0	0.615	1.000	1.000
564	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	DPYD(6), DTYMK(1), ENTPD1(1), ENTPD8(1), NME2(1), NT5E(1), PNPT1(2), POLD1(2), POLE(5), PRIM2(1), RRM2(1), TXNRD1(4), TXNRD2(2), UMPS(1), UPP2(1)	30177398	30	22	30	10	2	10	7	7	4	0	0.510	1.000	1.000
565	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	BRAF(1), DRD2(1), EGFR(2), EPHB2(1), ITPKA(1), ITPR1(4), ITPR2(6), ITPR3(2), KCNJ3(1), KCNJ5(2), MAPK1(1), PI3(1), PIK3CB(1), PLCB1(4), PLCB2(1), PLCB3(1), PLCB4(3)	21573580	33	21	33	13	9	9	2	9	4	0	0.563	1.000	1.000
566	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	31	APC(5), AXIN1(1), AXIN2(2), DKK2(1), DVL1(2), LRP1(4), MVP(1), NKD2(2), PIN1(1), PTPRA(1), WIF1(3)	15107513	23	21	23	12	5	4	3	3	8	0	0.817	1.000	1.000
567	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ALDH1A3(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), AOC3(1), ASPA(1), DDC(2), FTCD(1), HARS2(1), HDC(3), HEMK1(1), MAOB(1), PRMT2(2), PRMT3(1), PRMT6(1), PRMT8(1), UROC1(2), WBSCR22(1)	14839061	24	20	24	10	7	6	5	4	2	0	0.649	1.000	1.000
568	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(1), ABAT(1), ACAT1(1), AKR1B10(1), ALDH1A3(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), BDH2(2), GAD1(1), GAD2(2), HMGCS1(1), HMGCS2(1), HSD17B4(1), ILVBL(1), OXCT2(1), PDHA2(2), PDHB(1), PLA1A(2)	15067206	24	20	24	12	3	6	8	4	3	0	0.821	1.000	1.000
569	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	AGXT2(1), ALAS1(1), ALAS2(2), AOC3(1), CBS(1), CHDH(1), CPT1B(1), DMGDH(1), MAOB(1), PLCB2(1), PLCG1(2), PSPH(1), SARDH(3), SARS(2), TARS(1)	15858562	20	19	20	11	2	7	4	5	2	0	0.833	1.000	1.000
570	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ARG2(2), CPS1(1), EPRS(1), LAP3(2), NOS1(6), NOS3(2), P4HA2(1), P4HA3(1), PRODH(1), PYCR1(2), RARS(2)	13499792	21	19	21	10	6	7	5	0	3	0	0.614	1.000	1.000
571	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSE(1), CERK(1), GAL3ST1(1), GALC(2), GBA(1), GLA(1), LCT(4), NEU3(2), PPAP2A(1), PPAP2C(1), SGMS1(1), SGPP1(2), SMPD2(1), SMPD3(2), SPHK2(2), SPTLC1(1), UGT8(2)	13202900	26	19	25	11	4	6	4	3	9	0	0.683	1.000	1.000
572	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	B3GNT2(2), B4GALNT1(3), FUT1(3), FUT2(1), FUT5(1), FUT9(3), PIGB(1), PIGC(1), PIGG(1), PIGN(3), PIGT(1), ST3GAL5(1), ST6GALNAC3(1), ST6GALNAC5(1)	18011722	23	19	23	10	5	10	3	4	1	0	0.511	1.000	1.000
573	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	BCR(2), BLNK(2), LYN(1), MAPK1(1), MAPK8IP3(2), PAPPA(6), RAC1(1), RPS6KA1(1), SYK(1), VAV1(3), VAV2(3), VAV3(1)	12033101	24	18	24	10	5	6	4	4	5	0	0.600	1.000	1.000
574	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	AGXT2(1), AKR1B10(1), ALAS1(1), ALAS2(2), AOC3(1), CBS(1), CHDH(1), DMGDH(1), MAOB(1), PSPH(1), SARDH(3), SARS(2), TARS(1), TARS2(2)	16272176	19	17	19	10	2	7	5	4	1	0	0.760	1.000	1.000
575	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(1), ALOX15(1), ALOX5(1), CYP1A2(2), CYP2C18(3), CYP2C19(2), CYP2C9(2), CYP2E1(2), CYP2J2(2), CYP3A4(2), CYP3A7(1), PLA2G12B(1), PLA2G2D(1), PLA2G4A(1)	9052997	22	17	22	10	5	6	6	2	3	0	0.585	1.000	1.000
576	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(1), AKR1D1(2), ARSE(1), CYP11B1(3), CYP11B2(1), HSD11B1(1), HSD17B2(1), HSD3B1(1), SULT1E1(1), SULT2A1(1), UGT1A10(1), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT2B15(1)	9997289	19	16	19	13	4	1	1	7	6	0	0.988	1.000	1.000
577	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(2), MRPL19(1), RPL13A(1), RPL17(1), RPL36(1), RPL41(1), RPL5(3), RPL7(1), RPS20(1), RPS23(1), RPS26(1), RPS6KA1(1), RPS7(1), SLC36A2(2), UBB(2)	19665065	20	16	20	11	2	8	7	2	1	0	0.843	1.000	1.000
578	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS2(2), ABAT(1), ADSL(1), ADSSL1(1), AGXT2(1), ASNS(1), ASPA(1), ASRGL1(1), DARS(1), DLAT(1), GAD1(1), GAD2(2), GPT2(2), PDHA2(2), PDHB(1)	14000866	19	15	19	10	2	9	2	3	3	0	0.728	1.000	1.000
579	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(1), CPS1(1), EARS2(1), EPRS(1), GAD1(1), GAD2(2), GCLC(1), GLUL(1), GPT2(2), PPAT(1), QARS(1)	14466766	13	10	13	11	3	2	4	3	1	0	0.983	1.000	1.000
580	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	IL2RB(4), IL2RG(1), JAK1(1), JAK3(2), LCK(1), STAT5A(1), SYK(1)	8858150	11	10	11	5	4	3	2	2	0	0	0.602	1.000	1.000
581	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(1), CPS1(1), EPRS(1), GAD1(1), GAD2(2), GCLC(1), GLUL(1), GPT2(2), PPAT(1), QARS(1)	12130172	12	9	12	11	3	2	3	3	1	0	0.989	1.000	1.000
582	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B4GALNT1(3), LCT(4), ST3GAL5(1), ST6GALNAC3(1), ST6GALNAC5(1)	5891489	10	9	10	6	3	1	4	2	0	0	0.875	1.000	1.000
583	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	RPL13A(1), RPL36A(2), RPL41(1), RPL7(1), RPS20(1), RPS23(1), RPS26(1), RPS7(1)	8609902	9	9	9	4	4	1	3	1	0	0	0.817	1.000	1.000
584	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	HS3ST1(1), HS3ST3A1(1), HS3ST3B1(1), XYLT2(2)	2499150	5	5	5	4	1	2	1	1	0	0	0.868	1.000	1.000
585	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	HS3ST1(1), HS3ST3A1(1), HS3ST3B1(1), XYLT2(2)	2499150	5	5	5	4	1	2	1	1	0	0	0.868	1.000	1.000
586	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(1), GNAS(2), XPO1(1)	3488452	4	4	4	3	2	0	0	2	0	0	0.917	1.000	1.000
587	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(2), CYP2A13(1), CYP2A6(1)	2980611	4	4	4	3	1	1	1	1	0	0	0.839	1.000	1.000
588	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	FADS2(1), PLA2G12B(1), PLA2G2D(1), PLA2G4A(1)	3951462	4	4	4	5	1	2	1	0	0	0	0.981	1.000	1.000
589	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCR3(1), HLA-DRB1(1), IL5RA(2)	1950510	4	4	4	3	1	0	1	2	0	0	0.888	1.000	1.000
590	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	HMGB1(1), TOP2A(1), TOP2B(1)	3905917	3	3	3	3	0	0	1	2	0	0	0.979	1.000	1.000
591	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	GAD1(1), GAD2(2), GGT1(1)	2153032	4	3	4	3	0	1	1	2	0	0	0.891	1.000	1.000
592	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	GREB1(2), PDZK1(1), TUBA8(1)	4188823	4	3	4	4	2	0	0	2	0	0	0.917	1.000	1.000
593	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNH(1), CDC25B(1), XPO1(1)	3204314	3	3	3	3	0	2	0	1	0	0	0.935	1.000	1.000
594	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCR3(1), HLA-DRB1(1)	1120455	2	2	2	3	1	0	1	0	0	0	0.958	1.000	1.000
595	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(1), PGLYRP2(1)	639317	2	2	2	2	1	0	1	0	0	0	0.960	1.000	1.000
596	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA2(1), JAK1(1)	3899948	2	2	2	3	0	1	1	0	0	0	0.977	1.000	1.000
597	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA2(1), JAK1(1)	3899948	2	2	2	3	0	1	1	0	0	0	0.977	1.000	1.000
598	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	PRODH(1)	2159482	1	1	1	2	1	0	0	0	0	0	0.960	1.000	1.000
599	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	HLA-DRB1(1)	1440279	1	1	1	2	1	0	0	0	0	0	0.945	1.000	1.000
600	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(1)	1161150	1	1	1	2	0	0	0	1	0	0	0.981	1.000	1.000
601	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	ARHGAP5(1)	4648388	1	1	1	2	0	0	0	1	0	0	0.977	1.000	1.000
602	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(1)	806027	1	1	1	3	0	0	1	0	0	0	0.991	1.000	1.000
603	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMPR2(1)	2236538	1	1	1	2	0	1	0	0	0	0	0.951	1.000	1.000
604	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5		1787097	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
605	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2		587010	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
606	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4		1622826	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
607	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1		261215	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
608	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		186864	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
609	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3		819572	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
610	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4		1119807	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
611	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2		550247	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
612	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23		8421688	0	0	0	2	0	0	0	0	0	0	1.000	1.000	1.000
613	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	19		4999135	0	0	0	2	0	0	0	0	0	0	1.000	1.000	1.000
614	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3		603726	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
615	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6		1349812	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
616	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15		2627070	0	0	0	2	0	0	0	0	0	0	1.000	1.000	1.000
