rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(12)	306695	12	12	11	3	10	1	1	0	0	0	0.131	0.239	1.000
2	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1	CMBL(5)	219519	5	5	5	1	5	0	0	0	0	0	0.373	0.359	1.000
3	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(6), GOT2(6), TAT(21)	1124647	33	21	32	9	24	3	2	1	3	0	0.0125	0.898	1.000
4	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(5), CHRNA1(7), SNAP25(7), VAMP2(1)	1396359	20	18	18	3	14	1	0	2	3	0	0.00242	0.946	1.000
5	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(4), TPI1(1)	708066	5	5	4	1	3	0	0	2	0	0	0.339	0.972	1.000
6	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(2), LIPT1(2)	659766	4	3	4	0	0	2	0	1	1	0	0.334	0.981	1.000
7	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3D(7), CD3E(2), CD3G(1)	480032	10	7	10	4	8	0	0	0	2	0	0.405	0.992	1.000
8	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(17), ADH1B(30), ADH4(12), ADH6(14), ADH7(16), ADHFE1(6)	2409018	95	71	78	29	77	4	5	6	3	0	0.00244	0.995	1.000
9	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(4), ALDOA(1), ALDOB(14), ALDOC(4), TPI1(1)	1685752	24	19	21	7	17	2	0	2	3	0	0.0344	0.997	1.000
10	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(7), ALDH1A2(16), RDH5(2)	1670003	25	20	22	6	15	2	0	4	4	0	0.0318	0.997	1.000
11	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	CDK5(6), FOSB(5), GRIA2(43), JUND(1), PPP1R1B(2)	1573577	57	49	54	22	34	3	2	9	9	0	0.132	0.999	1.000
12	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(9), SLPI(6)	734750	15	14	15	7	7	1	0	6	1	0	0.587	0.999	1.000
13	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(7), DCN(19), FMOD(6), KERA(16), LUM(12)	1512551	60	45	56	25	46	5	3	3	3	0	0.0224	1.000	1.000
14	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(6), NFKB1(6), NFKBIA(2), PLCB1(58), PRKCA(9), RELA(4)	3497971	85	60	76	28	64	3	3	8	7	0	0.0155	1.000	1.000
15	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALT(2), TGDS(1), UGDH(1), UXS1(5)	1645771	9	9	9	8	3	0	1	0	5	0	0.951	1.000	1.000
16	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	BCL2(3), CASP3(2), CASP8(9), CFL1(2), CFLAR(4), PDE6D(2)	1669286	22	20	21	9	10	2	2	5	3	0	0.487	1.000	1.000
17	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	7	SEC61A2(2), SRP19(2), SRP54(4), SRP68(8), SRP72(1), SRP9(1), SRPR(4)	2818836	22	21	22	6	8	0	1	6	7	0	0.355	1.000	1.000
18	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(34), GNAS(33), GNB1(1), PRKACA(3), PRKAR1A(3)	2790154	74	51	70	24	46	11	4	7	6	0	0.0123	1.000	1.000
19	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(5), ACADM(5), ACADS(5), ECHS1(3), HADHA(6)	2335984	24	23	24	8	14	4	1	4	1	0	0.288	1.000	1.000
20	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYA(1), NFYB(2), NFYC(2), RB1(10), SP1(5), SP3(1)	2847454	21	18	21	6	5	2	2	4	6	2	0.329	1.000	1.000
21	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALT(2), TGDS(1), UGDH(1), UGP2(1), UXS1(5)	2099109	10	10	10	9	4	0	1	0	5	0	0.960	1.000	1.000
22	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT2(1), HMGCL(4), OXCT1(4)	1438077	9	9	9	5	6	0	0	1	2	0	0.721	1.000	1.000
23	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD28(2), CD4(9), HLA-DRA(13), HLA-DRB1(5)	1006636	29	24	27	15	23	0	0	3	3	0	0.197	1.000	1.000
24	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(14), LPL(6), NR3C1(7), PPARG(12), RETN(3), RXRA(4), TNF(1)	2489206	47	40	44	17	29	7	0	6	5	0	0.0415	1.000	1.000
25	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ2(2), COQ3(2), COQ5(2), COQ6(2), COQ7(3), NDUFA12(1), NDUFA13(2)	1700209	14	14	14	7	9	1	2	0	2	0	0.606	1.000	1.000
26	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCL11(3), CCR3(11), CSF2(2), HLA-DRA(13), HLA-DRB1(5), IL3(3), IL5(4)	1295425	41	29	39	20	33	1	0	4	3	0	0.0602	1.000	1.000
27	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	6	HDAC1(2), MYC(5), SP1(5), SP3(1), WT1(10)	2678875	23	20	22	6	12	4	3	1	3	0	0.117	1.000	1.000
28	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(5), PLCD1(3), PRKCA(9), TGM2(11)	2124288	28	23	27	13	21	2	0	0	5	0	0.0890	1.000	1.000
29	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	11	CCNA1(16), CCND1(2), CCNE1(4), CCNE2(6), CDK2(1), CDKN1B(1), E2F1(6), E2F2(5), E2F4(3), PRB1(14)	3315113	58	43	56	18	43	0	3	7	5	0	0.0437	1.000	1.000
30	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(2), GLS2(3), GLUD1(2), GLUD2(4)	1942316	11	9	11	9	3	3	1	1	3	0	0.916	1.000	1.000
31	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(4), ACP2(3), ACP5(3), ACPP(9), ACPT(3), ENPP1(13), ENPP3(14), FLAD1(11), TYR(11)	4128130	71	50	68	20	46	4	2	5	14	0	0.0107	1.000	1.000
32	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(1), FDPS(3), IDI1(1), SQLE(4)	1354168	9	9	9	5	4	1	1	3	0	0	0.710	1.000	1.000
33	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	HRAS(3), MMP14(3), MMP2(9), MMP9(8), RECK(11), TIMP1(1), TIMP2(2), TIMP3(5), TIMP4(7)	3182420	49	38	47	19	25	4	3	9	8	0	0.129	1.000	1.000
34	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	B3GNT1(3), FUT1(4), FUT2(4), FUT9(29), GCNT2(1), ST8SIA1(1)	2568161	42	39	39	20	28	3	4	7	0	0	0.231	1.000	1.000
35	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(4), ECHS1(3), EHHADH(6), HADHA(6), SDS(3)	2066224	22	19	20	10	14	3	0	3	2	0	0.356	1.000	1.000
36	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(5), AASDHPPT(3), AASS(3), KARS(4)	1992973	15	15	15	7	13	0	0	1	1	0	0.629	1.000	1.000
37	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	CAMP(2), DAG1(9), GNAQ(6), ITPKB(11)	2566827	28	24	26	12	20	0	2	2	4	0	0.164	1.000	1.000
38	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	12	CCND1(2), CDK2(1), CDKN1A(3), CDKN1B(1), CFL1(2), E2F1(6), E2F2(5), MDM2(4), NXT1(2), PRB1(14)	2727321	40	34	39	15	26	3	1	4	6	0	0.120	1.000	1.000
39	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(8), CDC25B(4), CDK7(2), CDKN1A(3), CHEK1(2), NEK1(7), WEE1(2)	2947162	28	23	28	8	15	5	1	4	3	0	0.226	1.000	1.000
40	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(16), GAD1(14), HDC(25), PNMT(4), TH(11), TPH1(12)	2549058	82	61	77	32	63	5	3	1	10	0	0.00163	1.000	1.000
41	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(2), CYCS(1), GPD2(3), SDHA(4), SDHC(3), SDHD(1), UQCRC1(4)	2839542	18	17	18	9	11	0	1	4	1	1	0.641	1.000	1.000
42	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	LDLR(17), NR0B2(6), NR1H3(4), NR1H4(14), RXRA(4)	2322057	45	32	45	19	28	7	3	5	2	0	0.0913	1.000	1.000
43	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(6), BAK1(2), BAX(4), BCL10(3), BCL2(3), BCL2L11(8), CASP9(2), CES1(21)	4579626	49	36	46	14	34	6	2	3	4	0	0.0550	1.000	1.000
44	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	AKR1A1(4), ECHS1(3), EHHADH(6), HADH(3), HADHA(6), HSD17B10(2), HSD17B4(6), NTAN1(2), SIRT1(2), SIRT2(1), SIRT5(6), SIRT7(3), VNN2(17)	5055319	61	50	59	18	38	8	4	7	4	0	0.0265	1.000	1.000
45	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CSF2(2), CSF3(4), EPO(5), FLT3(38), IGF1(11), IL11(3), IL1A(5), IL3(3), IL6(2), IL9(1), KITLG(10), TGFB1(2), TGFB2(3), TGFB3(3)	3515566	92	63	86	34	54	6	6	14	12	0	0.0122	1.000	1.000
46	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	PAPSS1(4), PAPSS2(5), SULT1A2(3), SULT1E1(16), SULT2A1(9), SUOX(4)	2605387	41	25	39	14	28	1	0	4	8	0	0.110	1.000	1.000
47	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(6), BMPR1A(2), BMPR1B(4), BMPR2(7)	2683733	19	19	19	9	10	3	1	3	2	0	0.554	1.000	1.000
48	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(9), CTH(1), GOT1(6), GOT2(6), LDHA(5), LDHB(2), LDHC(7), MPST(2)	2934593	38	30	36	15	27	2	6	2	1	0	0.150	1.000	1.000
49	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(13), IARS(10), LARS(13), LARS2(5), PDHA1(4), PDHA2(20), PDHB(1)	4290028	66	51	62	20	44	6	2	7	7	0	0.0641	1.000	1.000
50	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(5), AASDH(5), AASDHPPT(3), AASS(3), KARS(4)	2952936	20	18	20	9	17	0	0	1	2	0	0.608	1.000	1.000
51	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(6), FARSA(8), FARSB(5), GOT1(6), GOT2(6), PAH(12), TAT(21), YARS(3), YARS2(2)	3720330	69	50	66	29	44	7	2	5	11	0	0.0529	1.000	1.000
52	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	187	ACTB(9), ACTG1(7), ACTN1(8), ACTN2(21), ACTN4(5), AKT1(4), AKT2(8), AKT3(3), ARHGAP5(13), BCAR1(5), BCL2(3), BIRC2(6), BIRC3(7), CAPN2(6), CAV1(1), CAV3(2), CCND1(2), CCND2(7), CCND3(2), CDC42(2), CHAD(4), COL11A1(77), COL11A2(51), COL1A1(48), COL1A2(49), COL2A1(44), COL3A1(87), COL4A1(66), COL4A2(36), COL4A4(122), COL4A6(43), COL5A1(83), COL5A2(57), COL5A3(77), COL6A1(13), COL6A2(24), COL6A3(69), COL6A6(64), COMP(8), CRK(3), CRKL(2), CTNNB1(17), DIAPH1(10), DOCK1(17), EGF(22), EGFR(25), ELK1(3), ERBB2(10), FARP2(7), FIGF(5), FLNA(23), FLNB(44), FLNC(69), FLT1(42), FN1(28), FYN(8), GRB2(2), GSK3B(3), HGF(30), HRAS(3), IBSP(9), IGF1(11), IGF1R(15), ILK(2), ITGA1(23), ITGA10(12), ITGA11(19), ITGA2(13), ITGA2B(12), ITGA3(8), ITGA4(45), ITGA5(25), ITGA6(12), ITGA7(25), ITGA8(39), ITGA9(15), ITGAV(11), ITGB1(4), ITGB3(16), ITGB4(22), ITGB5(9), ITGB6(11), ITGB7(7), ITGB8(19), JUN(1), KDR(57), LAMA1(46), LAMA2(69), LAMA3(70), LAMA4(12), LAMA5(41), LAMB1(13), LAMB2(14), LAMB3(26), LAMB4(47), LAMC1(13), LAMC2(21), LAMC3(11), MAPK1(4), MAPK10(9), MAPK3(3), MAPK8(2), MAPK9(4), MET(23), MYL2(9), MYL5(1), MYL7(3), MYL9(2), MYLK(48), MYLK2(13), PAK1(4), PAK2(9), PAK3(10), PAK4(8), PAK6(6), PAK7(55), PARVA(2), PARVB(4), PARVG(3), PDGFA(1), PDGFB(6), PDGFC(17), PDGFD(7), PDGFRA(32), PDGFRB(23), PDPK1(5), PGF(1), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(3), PIK3R2(6), PIK3R3(2), PIK3R5(17), PIP5K1C(9), PPP1CA(3), PPP1CB(5), PPP1CC(2), PPP1R12A(4), PRKCA(9), PRKCG(16), PTK2(7), PXN(2), RAC2(1), RAF1(11), RAP1A(1), RAP1B(1), RAPGEF1(14), RELN(90), RHOA(2), ROCK1(6), ROCK2(14), SHC1(2), SHC2(7), SHC3(15), SHC4(4), SOS1(10), SOS2(13), SPP1(7), SRC(2), THBS1(31), THBS2(14), THBS3(12), THBS4(19), TLN1(12), TLN2(27), TNC(35), TNN(55), TNR(84), TNXB(126), VASP(3), VAV1(19), VAV2(5), VAV3(11), VCL(9), VEGFA(4), VEGFB(2), VTN(9), VWF(59), ZYX(8)	156127119	3540	267	3371	1596	2479	250	103	299	385	24	3.24e-07	1.000	1.000
53	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	136	ACTB(9), ACTG1(7), CHAD(4), COL11A1(77), COL11A2(51), COL17A1(29), COL1A1(48), COL1A2(49), COL2A1(44), COL3A1(87), COL4A1(66), COL4A2(36), COL4A4(122), COL4A6(43), COL5A1(83), COL5A2(57), COL5A3(77), COL6A1(13), COL6A2(24), COL6A3(69), COL6A6(64), COMP(8), DES(9), DSC1(57), DSC2(45), DSC3(50), DSG1(64), DSG2(26), DSG3(68), DSG4(70), FN1(28), GJA1(10), GJA10(18), GJA3(1), GJA4(4), GJA5(11), GJA8(20), GJA9(3), GJB1(1), GJB2(3), GJB3(4), GJB4(8), GJB5(8), GJB6(6), GJB7(2), GJC1(7), GJC3(2), GJD2(5), IBSP(9), INA(7), ITGA6(12), ITGB4(22), KRT1(22), KRT10(14), KRT12(11), KRT13(13), KRT14(3), KRT15(10), KRT16(10), KRT17(9), KRT18(4), KRT19(3), KRT2(18), KRT20(7), KRT23(10), KRT24(7), KRT25(14), KRT27(6), KRT28(13), KRT3(16), KRT31(9), KRT32(15), KRT33A(6), KRT33B(4), KRT34(12), KRT35(11), KRT36(18), KRT37(13), KRT38(10), KRT39(16), KRT4(22), KRT40(7), KRT5(16), KRT6A(15), KRT6B(9), KRT6C(14), KRT7(5), KRT71(18), KRT72(11), KRT73(18), KRT74(16), KRT75(16), KRT76(17), KRT77(15), KRT78(24), KRT79(8), KRT8(7), KRT81(4), KRT82(7), KRT83(16), KRT84(12), KRT85(7), KRT86(8), KRT9(23), LAMA1(46), LAMA2(69), LAMA3(70), LAMA4(12), LAMA5(41), LAMB1(13), LAMB2(14), LAMB3(26), LAMB4(47), LAMC1(13), LAMC2(21), LAMC3(11), LMNA(5), LMNB1(2), LMNB2(4), NES(25), PRPH(1), RELN(90), SPP1(7), THBS1(31), THBS2(14), THBS3(12), THBS4(19), TNC(35), TNN(55), TNR(84), TNXB(126), VIM(6), VTN(9), VWF(59)	106337368	3233	260	3055	1413	2362	234	79	225	315	18	1.16e-10	1.000	1.000
54	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	234	ADCYAP1R1(19), ADORA1(5), ADORA2A(3), ADORA2B(1), ADORA3(12), ADRA1A(13), ADRA1B(5), ADRA2A(3), ADRA2B(10), ADRA2C(2), ADRB1(5), ADRB2(4), AGTR1(10), AGTR2(10), AVPR1A(4), AVPR1B(13), BDKRB1(6), BDKRB2(10), BRS3(5), C3AR1(6), C5AR1(10), CALCR(19), CALCRL(19), CCKAR(12), CCKBR(11), CGA(1), CHRM1(5), CHRM2(26), CHRM3(26), CHRM4(6), CHRM5(7), CNR1(12), CNR2(6), CRHR1(7), CRHR2(5), CTSG(5), CYSLTR1(5), CYSLTR2(4), DRD1(9), DRD2(16), DRD3(5), DRD4(1), DRD5(25), EDNRA(11), EDNRB(7), F2(13), F2R(8), F2RL1(9), F2RL2(8), F2RL3(5), FPR1(22), FSHB(9), FSHR(21), GABBR1(9), GABBR2(12), GABRA1(20), GABRA2(19), GABRA3(24), GABRA4(15), GABRA5(4), GABRA6(29), GABRB1(16), GABRB2(26), GABRB3(23), GABRD(5), GABRE(24), GABRG2(20), GABRG3(10), GABRP(16), GABRQ(12), GABRR1(10), GALR1(5), GALR3(2), GH1(5), GH2(7), GHR(43), GHRHR(6), GHSR(11), GIPR(4), GLP1R(13), GLP2R(15), GLRA1(13), GLRA2(6), GLRA3(16), GNRHR(2), GPR156(15), GPR35(6), GPR50(19), GPR63(9), GPR83(14), GRIA1(47), GRIA2(43), GRIA3(26), GRIA4(26), GRID1(27), GRID2(60), GRIK1(30), GRIK2(31), GRIK3(34), GRIK4(16), GRIK5(12), GRIN1(8), GRIN2A(107), GRIN2B(59), GRIN2C(10), GRIN2D(11), GRIN3A(50), GRIN3B(5), GRM1(13), GRM2(16), GRM3(62), GRM4(22), GRM5(17), GRM6(32), GRM7(41), GRM8(47), GRPR(7), GZMA(13), HCRTR1(2), HCRTR2(34), HRH1(15), HRH2(3), HRH3(5), HRH4(6), HTR1A(11), HTR1B(2), HTR1D(7), HTR1E(7), HTR1F(9), HTR2A(11), HTR2B(2), HTR2C(14), HTR4(8), HTR5A(19), HTR6(3), HTR7(10), LEP(4), LEPR(31), LHB(1), LHCGR(29), LTB4R(1), LTB4R2(1), MAS1(4), MC1R(1), MC2R(5), MC3R(7), MC4R(1), MC5R(8), MCHR1(4), MCHR2(21), MLNR(2), MTNR1A(10), MTNR1B(8), NMBR(8), NMUR1(7), NMUR2(16), NPBWR1(3), NPBWR2(12), NPFFR1(1), NPFFR2(14), NPY1R(29), NPY2R(13), NPY5R(25), NR3C1(7), NTSR1(8), NTSR2(2), OPRD1(3), OPRK1(23), OPRL1(8), OPRM1(5), OXTR(6), P2RX1(3), P2RX2(3), P2RX3(8), P2RX4(2), P2RX5(6), P2RX7(4), P2RY1(5), P2RY10(7), P2RY11(2), P2RY13(4), P2RY14(8), P2RY2(10), P2RY4(2), P2RY6(2), P2RY8(9), PARD3(20), PRL(3), PRLHR(1), PRLR(37), PRSS1(26), PRSS3(6), PTAFR(2), PTGDR(12), PTGER2(7), PTGER3(4), PTGER4(3), PTGFR(21), PTGIR(5), PTH2R(18), RXFP1(19), RXFP2(25), SCTR(8), SSTR1(10), SSTR2(7), SSTR3(13), SSTR4(4), SSTR5(4), TAAR1(3), TAAR2(11), TAAR5(4), TAAR6(11), TAAR8(7), TACR1(8), TACR2(9), TACR3(29), TBXA2R(4), THRA(2), THRB(18), TRHR(24), TRPV1(3), TSHB(7), TSHR(8), UTS2R(1), VIPR1(7), VIPR2(7)	92988565	2867	258	2645	1801	1967	251	97	264	275	13	4.25e-09	1.000	1.000
55	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(16), CD36(6), CD44(5), CD47(1), CHAD(4), COL11A1(77), COL11A2(51), COL1A1(48), COL1A2(49), COL2A1(44), COL3A1(87), COL4A1(66), COL4A2(36), COL4A4(122), COL4A6(43), COL5A1(83), COL5A2(57), COL5A3(77), COL6A1(13), COL6A2(24), COL6A3(69), COL6A6(64), DAG1(9), FN1(28), FNDC1(44), FNDC3A(12), FNDC4(5), FNDC5(3), GP5(6), GP6(5), GP9(6), HMMR(5), HSPG2(31), IBSP(9), ITGA1(23), ITGA10(12), ITGA11(19), ITGA2(13), ITGA2B(12), ITGA3(8), ITGA4(45), ITGA5(25), ITGA6(12), ITGA7(25), ITGA8(39), ITGA9(15), ITGAV(11), ITGB1(4), ITGB3(16), ITGB4(22), ITGB5(9), ITGB6(11), ITGB7(7), ITGB8(19), LAMA1(46), LAMA2(69), LAMA3(70), LAMA4(12), LAMA5(41), LAMB1(13), LAMB2(14), LAMB3(26), LAMB4(47), LAMC1(13), LAMC2(21), LAMC3(11), RELN(90), SDC1(3), SDC2(2), SDC3(7), SDC4(3), SPP1(7), SV2A(17), SV2B(27), SV2C(22), THBS1(31), THBS2(14), THBS3(12), THBS4(19), TNC(35), TNN(55), TNR(84), TNXB(126), VTN(9), VWF(59)	95453432	2557	257	2437	1106	1845	160	78	178	277	19	0.000252	1.000	1.000
56	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	242	ACVR1B(3), ACVR1C(10), AKT1(4), AKT2(8), AKT3(3), ARRB1(4), ARRB2(7), ATF2(6), ATF4(9), BDNF(5), CACNA1A(38), CACNA1B(38), CACNA1C(60), CACNA1D(36), CACNA1E(113), CACNA1F(24), CACNA1G(37), CACNA1H(29), CACNA1I(41), CACNA1S(54), CACNA2D1(16), CACNA2D2(16), CACNA2D3(61), CACNA2D4(26), CACNB1(4), CACNB2(14), CACNB3(3), CACNB4(13), CACNG1(4), CACNG2(11), CACNG3(25), CACNG4(4), CACNG5(11), CACNG6(6), CACNG7(7), CACNG8(1), CASP3(2), CD14(6), CDC25B(4), CDC42(2), CHUK(2), CRK(3), CRKL(2), DAXX(10), DDIT3(3), DUSP1(1), DUSP10(9), DUSP14(2), DUSP16(4), DUSP2(1), DUSP3(1), DUSP4(3), DUSP5(2), DUSP6(2), DUSP7(2), DUSP8(3), DUSP9(3), ECSIT(2), EGF(22), EGFR(25), ELK1(3), ELK4(6), FAS(5), FASLG(15), FGF1(1), FGF10(3), FGF11(3), FGF12(15), FGF13(7), FGF14(5), FGF16(4), FGF17(2), FGF18(3), FGF19(3), FGF2(1), FGF20(2), FGF21(6), FGF23(10), FGF3(5), FGF4(2), FGF5(11), FGF6(6), FGF7(7), FGF8(1), FGF9(4), FGFR1(12), FGFR2(33), FGFR3(9), FGFR4(12), FLNA(23), FLNB(44), FLNC(69), FOS(2), GADD45B(2), GNA12(3), GRB2(2), HRAS(3), IKBKB(4), IL1A(5), IL1B(8), IL1R1(12), IL1R2(7), JUN(1), JUND(1), KRAS(7), MAP2K2(5), MAP2K3(9), MAP2K4(4), MAP2K5(5), MAP2K6(3), MAP2K7(5), MAP3K1(4), MAP3K10(13), MAP3K12(3), MAP3K13(15), MAP3K2(8), MAP3K3(8), MAP3K4(19), MAP3K5(23), MAP3K6(5), MAP3K7(1), MAP4K1(12), MAP4K2(7), MAP4K3(10), MAP4K4(12), MAPK1(4), MAPK10(9), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MAPK3(3), MAPK7(4), MAPK8(2), MAPK8IP1(7), MAPK8IP2(8), MAPK8IP3(9), MAPK9(4), MAPKAPK2(5), MAPKAPK3(5), MAPKAPK5(1), MAPT(10), MEF2C(3), MKNK1(6), MKNK2(4), MOS(6), MRAS(2), MYC(5), NF1(46), NFATC2(12), NFATC4(18), NFKB1(6), NFKB2(5), NLK(5), NR4A1(4), NTF3(7), NTRK1(16), NTRK2(11), PAK1(4), PAK2(9), PDGFA(1), PDGFB(6), PDGFRA(32), PDGFRB(23), PLA2G12B(3), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(19), PLA2G4A(16), PLA2G5(2), PLA2G6(13), PPM1A(3), PPM1B(2), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP5C(4), PRKACA(3), PRKACB(4), PRKACG(10), PRKCA(9), PRKCG(16), PRKX(3), PTPN5(13), PTPN7(2), PTPRR(30), RAC2(1), RAF1(11), RAP1A(1), RAP1B(1), RAPGEF2(9), RASA1(5), RASA2(15), RASGRF1(22), RASGRF2(24), RASGRP1(11), RASGRP2(8), RASGRP3(12), RASGRP4(12), RPS6KA1(9), RPS6KA2(6), RPS6KA3(2), RPS6KA4(4), RPS6KA5(7), RPS6KA6(21), RRAS(1), RRAS2(1), SOS1(10), SOS2(13), SRF(3), STK3(1), STK4(4), STMN1(3), TAOK1(11), TAOK2(24), TAOK3(4), TGFB1(2), TGFB2(3), TGFB3(3), TGFBR2(9), TNF(1), TNFRSF1A(4), TRAF2(2), TRAF6(4), ZAK(7)	118737394	2214	255	2126	1322	1433	210	70	211	273	17	0.490	1.000	1.000
57	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	168	ADCY1(34), ADCY2(10), ADCY3(3), ADCY4(5), ADCY7(13), ADCY8(54), ADCY9(11), ADORA2A(3), ADORA2B(1), ADRA1A(13), ADRA1B(5), ADRA1D(4), ADRB1(5), ADRB2(4), AGTR1(10), ATP2A1(13), ATP2A2(14), ATP2A3(15), ATP2B1(7), ATP2B2(30), ATP2B3(9), ATP2B4(17), AVPR1A(4), AVPR1B(13), BDKRB1(6), BDKRB2(10), BST1(2), CACNA1A(38), CACNA1B(38), CACNA1C(60), CACNA1D(36), CACNA1E(113), CACNA1F(24), CACNA1G(37), CACNA1H(29), CACNA1I(41), CACNA1S(54), CALM1(1), CALM2(1), CALML3(9), CALML6(1), CAMK2A(6), CAMK2B(6), CAMK2D(6), CAMK2G(5), CAMK4(17), CCKAR(12), CCKBR(11), CD38(6), CHRM1(5), CHRM2(26), CHRM3(26), CHRM5(7), CHRNA7(3), CYSLTR1(5), CYSLTR2(4), DRD1(9), EDNRA(11), EDNRB(7), EGFR(25), ERBB2(10), ERBB3(5), ERBB4(59), F2R(8), GNA11(9), GNA14(7), GNA15(7), GNAL(2), GNAQ(6), GNAS(33), GRIN1(8), GRIN2A(107), GRIN2C(10), GRIN2D(11), GRM1(13), GRM5(17), GRPR(7), HRH1(15), HRH2(3), HTR2A(11), HTR2B(2), HTR2C(14), HTR4(8), HTR5A(19), HTR6(3), HTR7(10), ITPKB(11), ITPR1(36), ITPR2(20), ITPR3(12), LHCGR(29), LTB4R2(1), MYLK(48), MYLK2(13), NOS1(77), NOS3(20), NTSR1(8), OXTR(6), P2RX1(3), P2RX2(3), P2RX3(8), P2RX4(2), P2RX5(6), P2RX7(4), PDE1A(44), PDE1B(15), PDE1C(54), PDGFRA(32), PDGFRB(23), PHKA1(25), PHKA2(9), PHKB(10), PHKG1(3), PHKG2(3), PLCB1(58), PLCB2(12), PLCB3(4), PLCB4(87), PLCD1(3), PLCD3(4), PLCD4(5), PLCE1(56), PLCG1(9), PLCG2(30), PLCZ1(30), PPID(1), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKACA(3), PRKACB(4), PRKACG(10), PRKCA(9), PRKCG(16), PRKX(3), PTAFR(2), PTGER3(4), PTGFR(21), PTK2B(12), RYR1(114), RYR2(99), RYR3(96), SLC25A6(2), SLC8A1(35), SLC8A2(14), SLC8A3(45), SPHK1(2), SPHK2(8), TACR1(8), TACR2(9), TACR3(29), TBXA2R(4), TNNC1(2), TNNC2(5), TRHR(24), TRPC1(6), VDAC1(1), VDAC2(1), VDAC3(1)	113494033	2822	255	2650	1779	1960	209	101	226	305	21	0.000147	1.000	1.000
58	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	249	ACVR1(2), ACVR1B(3), ACVR2A(5), ACVR2B(3), AMHR2(15), BMP2(7), BMP7(5), BMPR1A(2), BMPR1B(4), BMPR2(7), CCL1(3), CCL11(3), CCL14(2), CCL15(3), CCL16(2), CCL18(1), CCL2(3), CCL20(2), CCL21(2), CCL22(2), CCL23(1), CCL24(3), CCL25(1), CCL26(3), CCL27(2), CCL28(1), CCL7(5), CCL8(3), CCR1(10), CCR2(17), CCR3(11), CCR4(9), CCR5(10), CCR6(4), CCR7(4), CCR8(8), CCR9(6), CD27(3), CD40(4), CD40LG(1), CLCF1(1), CNTF(2), CNTFR(4), CRLF2(8), CSF1(12), CSF1R(13), CSF2(2), CSF2RA(23), CSF2RB(24), CSF3(4), CSF3R(10), CX3CL1(5), CX3CR1(16), CXCL10(3), CXCL11(1), CXCL12(2), CXCL13(2), CXCL14(3), CXCL3(2), CXCL5(3), CXCL6(2), CXCL9(2), CXCR3(4), CXCR4(3), CXCR6(6), EDA(2), EDA2R(4), EDAR(8), EGF(22), EGFR(25), EPO(5), EPOR(1), FAS(5), FASLG(15), FLT1(42), FLT3(38), FLT3LG(1), FLT4(31), GDF5(16), GH1(5), GH2(7), GHR(43), HGF(30), IFNA1(1), IFNA10(2), IFNA13(1), IFNA14(8), IFNA16(11), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA5(4), IFNA6(3), IFNA7(6), IFNA8(3), IFNAR1(3), IFNAR2(8), IFNB1(6), IFNG(4), IFNGR1(3), IFNGR2(4), IFNK(2), IFNW1(4), IL10(2), IL10RA(9), IL10RB(7), IL11(3), IL11RA(3), IL12A(4), IL12B(3), IL12RB1(15), IL12RB2(3), IL13(2), IL13RA1(4), IL15(3), IL15RA(6), IL17A(8), IL17B(4), IL17RA(5), IL17RB(2), IL18(3), IL18R1(21), IL18RAP(26), IL19(2), IL1A(5), IL1B(8), IL1R1(12), IL1R2(7), IL1RAP(3), IL2(4), IL20(4), IL20RA(11), IL21(6), IL21R(19), IL22(2), IL22RA1(13), IL22RA2(3), IL23A(2), IL23R(8), IL25(1), IL26(4), IL2RA(7), IL2RB(12), IL2RG(3), IL3(3), IL3RA(8), IL4(1), IL4R(18), IL5(4), IL5RA(16), IL6(2), IL6R(3), IL6ST(11), IL7(5), IL7R(37), IL9(1), IL9R(6), INHBA(20), INHBB(9), INHBC(13), INHBE(5), KDR(57), KIT(13), KITLG(10), LEP(4), LEPR(31), LIF(1), LIFR(39), LTA(5), LTB(3), MET(23), MPL(9), NGFR(8), OSM(5), OSMR(40), PDGFB(6), PDGFC(17), PDGFRA(32), PDGFRB(23), PF4V1(1), PLEKHO2(5), PPBP(6), PRL(3), PRLR(37), RELT(2), TGFB1(2), TGFB2(3), TGFB3(3), TGFBR2(9), TNF(1), TNFRSF10A(7), TNFRSF10B(5), TNFRSF10C(4), TNFRSF10D(9), TNFRSF11A(5), TNFRSF11B(15), TNFRSF12A(1), TNFRSF13B(11), TNFRSF14(3), TNFRSF17(7), TNFRSF18(5), TNFRSF19(2), TNFRSF1A(4), TNFRSF1B(4), TNFRSF21(14), TNFRSF25(6), TNFRSF4(5), TNFRSF6B(4), TNFRSF8(19), TNFRSF9(4), TNFSF10(9), TNFSF11(5), TNFSF12(2), TNFSF13B(3), TNFSF14(9), TNFSF15(8), TNFSF18(9), TNFSF4(5), TNFSF8(3), TNFSF9(4), TPO(47), TSLP(2), VEGFA(4), VEGFB(2), XCL1(1), XCL2(2), XCR1(7)	74935173	1808	253	1720	969	1254	137	48	158	210	1	0.00338	1.000	1.000
59	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	199	ABI2(2), ACTN1(8), ACTN2(21), ACTN4(5), APC(27), APC2(12), ARAF(5), ARHGEF1(1), ARHGEF12(13), ARHGEF4(6), ARHGEF6(11), ARHGEF7(5), ARPC1B(3), ARPC2(1), ARPC3(2), ARPC4(1), ARPC5(1), BAIAP2(8), BCAR1(5), BDKRB1(6), BDKRB2(10), CD14(6), CDC42(2), CFL1(2), CHRM1(5), CHRM2(26), CHRM3(26), CHRM4(6), CHRM5(7), CRK(3), CRKL(2), CSK(1), CYFIP1(8), CYFIP2(26), DIAPH1(10), DIAPH2(8), DIAPH3(20), DOCK1(17), EGF(22), EGFR(25), EZR(7), F2(13), F2R(8), FGD1(5), FGD3(9), FGF1(1), FGF10(3), FGF11(3), FGF12(15), FGF13(7), FGF14(5), FGF16(4), FGF17(2), FGF18(3), FGF19(3), FGF2(1), FGF20(2), FGF21(6), FGF23(10), FGF3(5), FGF4(2), FGF5(11), FGF6(6), FGF7(7), FGF8(1), FGF9(4), FGFR1(12), FGFR2(33), FGFR3(9), FGFR4(12), FN1(28), GIT1(6), GNA12(3), GNA13(1), GSN(6), HRAS(3), IQGAP1(10), IQGAP2(29), IQGAP3(13), ITGA1(23), ITGA10(12), ITGA11(19), ITGA2(13), ITGA2B(12), ITGA3(8), ITGA4(45), ITGA5(25), ITGA6(12), ITGA7(25), ITGA8(39), ITGA9(15), ITGAD(31), ITGAE(21), ITGAL(27), ITGAM(25), ITGAV(11), ITGAX(25), ITGB1(4), ITGB2(17), ITGB3(16), ITGB4(22), ITGB5(9), ITGB6(11), ITGB7(7), ITGB8(19), KRAS(7), LIMK1(5), LIMK2(12), MAP2K2(5), MAPK1(4), MAPK3(3), MOS(6), MRAS(2), MSN(2), MYH10(14), MYH14(24), MYH9(12), MYL2(9), MYL5(1), MYL7(3), MYL9(2), MYLK(48), MYLK2(13), NCKAP1(5), NCKAP1L(44), PAK1(4), PAK2(9), PAK3(10), PAK4(8), PAK6(6), PAK7(55), PDGFA(1), PDGFB(6), PDGFRA(32), PDGFRB(23), PFN4(1), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(3), PIK3R2(6), PIK3R3(2), PIK3R5(17), PIP4K2A(6), PIP4K2B(3), PIP4K2C(2), PIP5K1A(6), PIP5K1B(21), PIP5K1C(9), PPP1CA(3), PPP1CB(5), PPP1CC(2), PPP1R12A(4), PPP1R12B(9), PTK2(7), PXN(2), RAC2(1), RAF1(11), RDX(4), RHOA(2), ROCK1(6), ROCK2(14), RRAS(1), RRAS2(1), SCIN(9), SLC9A1(5), SOS1(10), SOS2(13), SSH1(15), SSH2(7), SSH3(4), TIAM1(28), TIAM2(28), VAV1(19), VAV2(5), VAV3(11), VCL(9), WAS(8), WASF1(5), WASF2(6), WASL(4)	115761986	1941	253	1865	1050	1253	150	72	234	220	12	0.0308	1.000	1.000
60	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	124	ABL1(15), ABLIM1(15), ABLIM2(10), ABLIM3(8), ARHGEF12(13), CDC42(2), CDK5(6), CFL1(2), CXCL12(2), CXCR4(3), DCC(102), DPYSL2(4), DPYSL5(15), EFNA1(1), EFNA2(1), EFNA4(2), EFNA5(4), EFNB1(2), EFNB3(3), EPHA1(22), EPHA2(18), EPHA3(34), EPHA4(22), EPHA5(7), EPHA6(78), EPHA7(54), EPHA8(21), EPHB1(31), EPHB2(36), EPHB3(17), EPHB4(15), EPHB6(26), FES(7), FYN(8), GNAI1(2), GNAI3(2), GSK3B(3), HRAS(3), ITGB1(4), KRAS(7), L1CAM(11), LIMK1(5), LIMK2(12), LRRC4C(50), MAPK1(4), MAPK3(3), MET(23), NCK1(2), NCK2(4), NFAT5(11), NFATC1(17), NFATC2(12), NFATC3(11), NFATC4(18), NGEF(13), NRP1(24), NTN4(19), NTNG1(14), PAK1(4), PAK2(9), PAK3(10), PAK4(8), PAK6(6), PAK7(55), PLXNA1(12), PLXNA2(10), PLXNA3(17), PLXNB1(23), PLXNB2(17), PLXNB3(6), PLXNC1(18), PPP3CA(5), PPP3CB(4), PPP3CC(2), PTK2(7), RAC2(1), RASA1(5), RGS3(16), RHOA(2), RHOD(2), RND1(6), ROBO1(25), ROBO2(47), ROBO3(19), ROCK1(6), ROCK2(14), SEMA3A(15), SEMA3C(4), SEMA3D(15), SEMA3E(31), SEMA3F(12), SEMA3G(15), SEMA4A(9), SEMA4B(4), SEMA4C(13), SEMA4D(10), SEMA4F(8), SEMA4G(8), SEMA5A(17), SEMA5B(21), SEMA6A(10), SEMA6B(8), SEMA6C(9), SEMA6D(7), SEMA7A(4), SLIT1(17), SLIT2(66), SLIT3(63), SRGAP1(7), SRGAP2(8), SRGAP3(39), UNC5A(13), UNC5B(12), UNC5C(19), UNC5D(35)	82507814	1735	246	1621	903	1183	142	49	167	185	9	0.00232	1.000	1.000
61	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ADCY1(34), ADCY2(10), ADCY3(3), ADCY4(5), ADCY5(19), ADCY6(9), ADCY7(13), ADCY8(54), ADCY9(11), ADRA1A(13), ADRA1B(5), ADRA1D(4), ADRB1(5), ADRB2(4), ANXA6(6), ARRB1(4), ARRB2(7), ATP1A4(15), ATP1B1(2), ATP1B3(1), ATP2A2(14), ATP2A3(15), ATP2B1(7), ATP2B2(30), ATP2B3(9), CACNA1A(38), CACNA1B(38), CACNA1C(60), CACNA1D(36), CACNA1E(113), CACNA1S(54), CACNB1(4), CACNB3(3), CALM1(1), CALM2(1), CALR(2), CAMK1(5), CAMK2A(6), CAMK2B(6), CAMK2D(6), CAMK2G(5), CAMK4(17), CASQ1(8), CASQ2(5), CHRM1(5), CHRM2(26), CHRM3(26), CHRM4(6), CHRM5(7), GJA1(10), GJA4(4), GJA5(11), GJB1(1), GJB2(3), GJB3(4), GJB4(8), GJB5(8), GJB6(6), GNA11(9), GNAI3(2), GNAO1(1), GNAQ(6), GNAZ(7), GNB1(1), GNB2(1), GNB3(7), GNB4(4), GNB5(2), GNG2(3), GNG4(3), GNG7(2), GRK4(10), GRK5(5), GRK6(3), ITPR1(36), ITPR2(20), ITPR3(12), KCNB1(37), KCNJ3(21), KCNJ5(13), MIB1(6), NME7(5), PKIA(3), PKIB(1), PKIG(1), PLCB3(4), PRKACA(3), PRKACB(4), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCA(9), PRKCD(5), PRKCE(7), PRKCG(16), PRKCH(9), PRKCQ(21), PRKCZ(3), PRKD1(9), RGS1(5), RGS11(4), RGS14(3), RGS16(3), RGS18(8), RGS2(2), RGS20(2), RGS3(16), RGS4(4), RGS5(4), RGS6(20), RGS7(41), RGS9(16), RYR1(114), RYR2(99), RYR3(96), SFN(2), SLC8A1(35), SLC8A3(45), USP5(8), YWHAB(1), YWHAQ(3)	78911028	1687	240	1591	1159	1151	146	72	130	179	9	0.432	1.000	1.000
62	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	127	ACTB(9), ACTG1(7), ACTN1(8), ACTN2(21), ACTN4(5), AKT1(4), AKT2(8), AKT3(3), AMOTL1(4), ASH1L(37), CASK(6), CDC42(2), CGN(9), CLDN1(5), CLDN10(8), CLDN11(5), CLDN14(5), CLDN15(1), CLDN16(7), CLDN17(5), CLDN18(11), CLDN19(2), CLDN2(6), CLDN20(1), CLDN22(2), CLDN3(3), CLDN4(12), CLDN6(9), CLDN7(1), CLDN8(4), CLDN9(1), CSNK2A1(2), CSNK2A2(1), CSNK2B(1), CTNNA1(3), CTNNA2(28), CTNNA3(39), CTNNB1(17), CTTN(4), EPB41(9), EPB41L1(16), EPB41L2(21), EPB41L3(7), EXOC3(6), EXOC4(12), F11R(7), GNAI1(2), GNAI3(2), HCLS1(15), HRAS(3), IGSF5(12), INADL(43), JAM2(11), JAM3(3), KRAS(7), LLGL1(5), LLGL2(16), MAGI1(38), MAGI2(24), MAGI3(12), MLLT4(17), MPDZ(13), MPP5(1), MRAS(2), MYH1(103), MYH10(14), MYH11(31), MYH13(55), MYH14(24), MYH15(64), MYH2(100), MYH3(31), MYH4(100), MYH6(40), MYH7(58), MYH7B(22), MYH8(66), MYH9(12), MYL2(9), MYL5(1), MYL7(3), MYL9(2), OCLN(6), PARD3(20), PARD6A(1), PARD6B(2), PARD6G(4), PPM1J(1), PPP2CA(1), PPP2CB(2), PPP2R1A(4), PPP2R1B(5), PPP2R2A(5), PPP2R2B(6), PPP2R2C(8), PPP2R3A(10), PPP2R3B(5), PPP2R4(2), PRKCA(9), PRKCD(5), PRKCE(7), PRKCG(16), PRKCH(9), PRKCI(8), PRKCQ(21), PRKCZ(3), RAB3B(1), RHOA(2), RRAS(1), RRAS2(1), SPTAN1(10), SRC(2), SYMPK(7), TJAP1(5), TJP1(16), TJP2(10), TJP3(20), VAPA(2), YES1(4), ZAK(7)	81236785	1593	239	1486	1018	1074	138	45	152	174	10	0.664	1.000	1.000
63	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	130	ALCAM(7), CADM1(5), CADM3(19), CD2(29), CD22(26), CD226(6), CD274(1), CD276(8), CD28(2), CD34(4), CD4(9), CD40(4), CD40LG(1), CD58(1), CD6(12), CD80(4), CD86(25), CD8A(2), CD8B(9), CD99(1), CDH1(6), CDH15(10), CDH2(16), CDH4(40), CDH5(12), CLDN1(5), CLDN10(8), CLDN11(5), CLDN14(5), CLDN15(1), CLDN16(7), CLDN17(5), CLDN18(11), CLDN19(2), CLDN2(6), CLDN20(1), CLDN22(2), CLDN3(3), CLDN4(12), CLDN6(9), CLDN7(1), CLDN8(4), CLDN9(1), CNTN1(28), CNTN2(16), CNTNAP1(12), CNTNAP2(94), CTLA4(2), ESAM(5), F11R(7), GLG1(6), HLA-A(4), HLA-B(6), HLA-C(2), HLA-DMA(7), HLA-DMB(7), HLA-DOA(6), HLA-DOB(9), HLA-DPA1(2), HLA-DPB1(2), HLA-DQA1(7), HLA-DQA2(8), HLA-DQB1(4), HLA-DRA(13), HLA-DRB1(5), HLA-DRB5(1), HLA-E(1), HLA-F(2), HLA-G(5), ICAM1(2), ICAM2(4), ICAM3(3), ICOS(3), ICOSLG(2), ITGA4(45), ITGA6(12), ITGA8(39), ITGA9(15), ITGAL(27), ITGAM(25), ITGAV(11), ITGB1(4), ITGB2(17), ITGB7(7), ITGB8(19), JAM2(11), JAM3(3), L1CAM(11), MADCAM1(1), MAG(12), MPZ(4), MPZL1(2), NCAM1(18), NCAM2(11), NEGR1(9), NEO1(16), NFASC(52), NLGN1(12), NLGN2(7), NLGN3(6), NRCAM(10), NRXN1(56), NRXN2(20), NRXN3(35), OCLN(6), PDCD1(4), PDCD1LG2(3), PTPRC(36), PTPRF(35), PTPRM(8), PVR(2), PVRL1(4), PVRL2(6), PVRL3(5), SDC1(3), SDC2(2), SDC3(7), SDC4(3), SELE(33), SELL(12), SELP(38), SELPLG(11), SIGLEC1(34), SPN(5), VCAM1(17), VCAN(44)	62403116	1457	236	1371	709	994	108	53	151	146	5	2.34e-05	1.000	1.000
64	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(4), ACTA2(5), ACTN2(21), ACTN4(5), DES(9), DMD(41), MYBPC1(27), MYBPC2(21), MYBPC3(16), MYH3(31), MYH6(40), MYH7(58), MYH8(66), MYL1(12), MYL2(9), MYL3(2), MYL4(6), MYL9(2), MYOM1(24), NEB(126), TNNC2(5), TNNI2(2), TNNI3(3), TNNT1(3), TNNT2(5), TNNT3(5), TPM1(4), TPM2(3), TPM3(2), TPM4(2), TTN(1152), VIM(6)	56716050	1717	236	1576	753	1250	124	57	148	120	18	6.48e-07	1.000	1.000
65	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	137	ACTA1(4), ACTA2(5), ADCY1(34), ADCY2(10), ADCY3(3), ADCY4(5), ADCY5(19), ADCY6(9), ADCY7(13), ADCY8(54), ADCY9(11), ADM(1), ARRB1(4), ARRB2(7), ATF1(5), ATF2(6), ATF3(1), ATF4(9), ATF5(9), ATP2A2(14), ATP2A3(15), CACNB3(3), CALCA(3), CALM1(1), CALM2(1), CAMK2A(6), CAMK2B(6), CAMK2D(6), CAMK2G(5), CNN1(8), CNN2(3), CORIN(29), CRHR1(7), DGKZ(9), ETS2(8), FOS(2), GABPA(6), GABPB2(8), GBA2(2), GJA1(10), GNAQ(6), GNB1(1), GNB2(1), GNB3(7), GNB4(4), GNB5(2), GNG2(3), GNG4(3), GNG7(2), GRK4(10), GRK5(5), GRK6(3), GSTO1(3), GUCA2A(2), GUCA2B(2), GUCY1A3(33), IGFBP1(3), IGFBP2(2), IGFBP3(3), IGFBP6(2), IL1B(8), IL6(2), ITPR1(36), ITPR2(20), ITPR3(12), JUN(1), MIB1(6), MYL2(9), MYL4(6), MYLK2(13), NFKB1(6), NOS1(77), NOS3(20), OXTR(6), PDE4B(8), PDE4D(7), PKIA(3), PKIB(1), PKIG(1), PLCB3(4), PLCD1(3), PLCG1(9), PLCG2(30), PRKACA(3), PRKACB(4), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCA(9), PRKCD(5), PRKCE(7), PRKCH(9), PRKCQ(21), PRKCZ(3), PRKD1(9), RAMP1(1), RAMP2(1), RAMP3(2), RGS1(5), RGS11(4), RGS14(3), RGS16(3), RGS18(8), RGS2(2), RGS20(2), RGS3(16), RGS4(4), RGS5(4), RGS6(20), RGS7(41), RGS9(16), RLN1(2), RYR1(114), RYR2(99), RYR3(96), SFN(2), SLC8A1(35), SP1(5), TNXB(126), USP5(8), YWHAB(1), YWHAQ(3)	73822322	1452	232	1376	861	1004	117	52	107	165	7	0.0159	1.000	1.000
66	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	162	ADORA1(5), ADORA2A(3), ADORA2B(1), ADORA3(12), ADRA1A(13), ADRA1B(5), ADRA1D(4), ADRA2A(3), ADRA2C(2), ADRB1(5), ADRB2(4), AGTR1(10), AGTR2(10), AVPR1A(4), AVPR1B(13), BDKRB1(6), BDKRB2(10), BRS3(5), C3AR1(6), CCKAR(12), CCKBR(11), CCR1(10), CCR10(2), CCR2(17), CCR3(11), CCR4(9), CCR5(10), CCR6(4), CCR7(4), CCR8(8), CCR9(6), CCRL2(6), CHML(5), CHRM1(5), CHRM2(26), CHRM3(26), CHRM4(6), CHRM5(7), CMKLR1(16), CNR1(12), CNR2(6), CX3CR1(16), CXCR3(4), CXCR4(3), DRD1(9), DRD2(16), DRD3(5), DRD4(1), DRD5(25), EDNRA(11), EDNRB(7), F2R(8), F2RL1(9), F2RL2(8), F2RL3(5), FPR1(22), FSHR(21), GALR1(5), GALR3(2), GALT(2), GHSR(11), GNB2L1(4), GPR17(1), GPR173(1), GPR174(12), GPR27(2), GPR3(3), GPR35(6), GPR37(10), GPR37L1(7), GPR4(5), GPR50(19), GPR6(7), GPR63(9), GPR83(14), GPR85(5), GPR87(6), GRPR(7), HCRTR1(2), HCRTR2(34), HRH1(15), HRH2(3), HRH3(5), HTR1A(11), HTR1B(2), HTR1D(7), HTR1E(7), HTR1F(9), HTR2A(11), HTR2B(2), HTR2C(14), HTR4(8), HTR5A(19), HTR6(3), HTR7(10), LHCGR(29), LTB4R(1), MAS1(4), MC1R(1), MC3R(7), MC4R(1), MC5R(8), MLNR(2), MTNR1A(10), MTNR1B(8), NMBR(8), NMUR1(7), NMUR2(16), NPY1R(29), NPY2R(13), NPY5R(25), NTSR1(8), NTSR2(2), OPN1SW(3), OPN3(4), OPRD1(3), OPRK1(23), OPRL1(8), OPRM1(5), OR10A5(10), OR11A1(6), OR12D3(9), OR1C1(14), OR1F1(8), OR1Q1(6), OR2H1(12), OR5V1(12), OR7A5(2), OR7C1(3), OR8B8(14), OXTR(6), P2RY1(5), P2RY10(7), P2RY11(2), P2RY12(4), P2RY13(4), P2RY14(8), P2RY2(10), P2RY6(2), PTAFR(2), PTGDR(12), PTGER2(7), PTGER4(3), PTGFR(21), PTGIR(5), RGR(8), RHO(2), RRH(2), SSTR1(10), SSTR2(7), SSTR3(13), SSTR4(4), SUCNR1(10), TBXA2R(4), TRHR(24)	51650384	1313	228	1224	996	888	135	48	138	103	1	0.00262	1.000	1.000
67	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	151	AKT1(4), AKT2(8), AKT3(3), CBL(10), CBLB(21), CBLC(16), CCND1(2), CCND2(7), CCND3(2), CISH(4), CLCF1(1), CNTF(2), CNTFR(4), CREBBP(24), CRLF2(8), CSF2(2), CSF2RA(23), CSF2RB(24), CSF3(4), CSF3R(10), EP300(19), EPO(5), EPOR(1), GH1(5), GH2(7), GHR(43), GRB2(2), IFNA1(1), IFNA10(2), IFNA13(1), IFNA14(8), IFNA16(11), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA5(4), IFNA6(3), IFNA7(6), IFNA8(3), IFNAR1(3), IFNAR2(8), IFNB1(6), IFNG(4), IFNGR1(3), IFNGR2(4), IFNK(2), IFNW1(4), IL10(2), IL10RA(9), IL10RB(7), IL11(3), IL11RA(3), IL12A(4), IL12B(3), IL12RB1(15), IL12RB2(3), IL13(2), IL13RA1(4), IL13RA2(6), IL15(3), IL15RA(6), IL19(2), IL2(4), IL20(4), IL20RA(11), IL21(6), IL21R(19), IL22(2), IL22RA1(13), IL22RA2(3), IL23A(2), IL23R(8), IL26(4), IL2RA(7), IL2RB(12), IL2RG(3), IL3(3), IL3RA(8), IL4(1), IL4R(18), IL5(4), IL5RA(16), IL6(2), IL6R(3), IL6ST(11), IL7(5), IL7R(37), IL9(1), IL9R(6), IRF9(2), JAK1(7), JAK2(8), JAK3(11), LEP(4), LEPR(31), LIF(1), LIFR(39), MPL(9), MYC(5), OSM(5), OSMR(40), PIAS1(7), PIAS2(5), PIAS3(6), PIAS4(1), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(3), PIK3R2(6), PIK3R3(2), PIK3R5(17), PIM1(1), PRL(3), PRLR(37), PTPN11(10), PTPN6(5), SOCS1(1), SOCS2(2), SOCS3(1), SOCS4(3), SOCS5(8), SOCS7(5), SOS1(10), SOS2(13), SPRED1(6), SPRED2(4), SPRY1(10), SPRY2(3), SPRY3(12), SPRY4(1), STAM(6), STAM2(3), STAT1(5), STAT2(6), STAT3(11), STAT4(26), STAT5A(3), STAT5B(5), STAT6(9), TPO(47), TSLP(2), TYK2(8)	61933245	1161	228	1115	577	750	96	38	131	144	2	0.0918	1.000	1.000
68	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	142	APC(27), APC2(12), AXIN1(10), AXIN2(5), BTRC(4), CACYBP(2), CAMK2A(6), CAMK2B(6), CAMK2D(6), CAMK2G(5), CCND1(2), CCND2(7), CCND3(2), CER1(18), CHD8(30), CREBBP(24), CSNK1A1(5), CSNK1A1L(7), CSNK1E(5), CSNK2A1(2), CSNK2A2(1), CSNK2B(1), CTBP2(1), CTNNB1(17), CTNNBIP1(1), CUL1(3), DAAM1(8), DAAM2(7), DKK1(3), DKK2(19), DKK4(4), DVL1(1), DVL2(3), DVL3(9), EP300(19), FBXW11(6), FZD1(5), FZD10(4), FZD2(7), FZD3(1), FZD4(1), FZD5(2), FZD6(2), FZD7(5), FZD8(6), FZD9(1), GSK3B(3), JUN(1), LEF1(3), LRP5(21), LRP6(14), MAP3K7(1), MAPK10(9), MAPK8(2), MAPK9(4), MMP7(4), MYC(5), NFAT5(11), NFATC1(17), NFATC2(12), NFATC3(11), NFATC4(18), NKD1(9), NKD2(7), NLK(5), PLCB1(58), PLCB2(12), PLCB3(4), PLCB4(87), PORCN(4), PPARD(3), PPP2CA(1), PPP2CB(2), PPP2R1A(4), PPP2R1B(5), PPP2R2A(5), PPP2R2B(6), PPP2R2C(8), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRICKLE1(11), PRICKLE2(6), PRKACA(3), PRKACB(4), PRKACG(10), PRKCA(9), PRKCG(16), PRKX(3), PSEN1(3), RAC2(1), RHOA(2), ROCK1(6), ROCK2(14), RUVBL1(1), SENP2(9), SFRP1(3), SFRP2(9), SFRP4(6), SFRP5(1), SMAD2(4), SMAD3(4), SMAD4(2), SOX17(8), TBL1X(4), TBL1XR1(3), TBL1Y(9), TCF7(1), TCF7L1(4), TCF7L2(7), VANGL1(3), VANGL2(8), WIF1(7), WNT1(2), WNT10A(7), WNT10B(6), WNT11(4), WNT16(4), WNT2(8), WNT2B(5), WNT3(5), WNT3A(8), WNT4(1), WNT5A(5), WNT5B(5), WNT6(3), WNT7A(13), WNT7B(6), WNT8A(6), WNT8B(8), WNT9A(4), WNT9B(6)	67919409	976	224	933	501	616	86	43	108	118	5	0.149	1.000	1.000
69	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	89	ADCY1(34), ADCY2(10), ADCY3(3), ADCY4(5), ADCY5(19), ADCY6(9), ADCY7(13), ADCY8(54), ADCY9(11), ADRB1(5), CSNK1D(3), DRD1(9), DRD2(16), EGF(22), EGFR(25), GJA1(10), GJD2(5), GNA11(9), GNAI1(2), GNAI3(2), GNAQ(6), GNAS(33), GRB2(2), GRM1(13), GRM5(17), GUCY1A2(20), GUCY1A3(33), GUCY1B3(8), GUCY2C(38), GUCY2D(10), GUCY2F(21), HRAS(3), HTR2A(11), HTR2B(2), HTR2C(14), ITPR1(36), ITPR2(20), ITPR3(12), KRAS(7), MAP2K2(5), MAP2K5(5), MAP3K2(8), MAPK1(4), MAPK3(3), MAPK7(4), NPR1(17), NPR2(21), PDGFA(1), PDGFB(6), PDGFC(17), PDGFD(7), PDGFRA(32), PDGFRB(23), PLCB1(58), PLCB2(12), PLCB3(4), PLCB4(87), PRKACA(3), PRKACB(4), PRKACG(10), PRKCA(9), PRKCG(16), PRKG1(14), PRKG2(16), PRKX(3), RAF1(11), SOS1(10), SOS2(13), SRC(2), TJP1(16), TUBA1A(4), TUBA1B(4), TUBA1C(2), TUBA3C(24), TUBA3D(13), TUBA3E(4), TUBA4A(7), TUBA8(5), TUBAL3(13), TUBB(1), TUBB1(5), TUBB2A(2), TUBB3(4), TUBB6(10), TUBB8(11)	55209936	1122	223	1048	635	763	89	43	104	118	5	0.00871	1.000	1.000
70	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	128	ACACA(23), ACACB(23), AKT1(4), AKT2(8), AKT3(3), ARAF(5), CALM1(1), CALM2(1), CALML3(9), CALML6(1), CBL(10), CBLB(21), CBLC(16), CRK(3), CRKL(2), EIF4EBP1(1), ELK1(3), EXOC7(8), FASN(25), FBP1(3), FBP2(2), FLOT1(1), FOXO1(6), G6PC(5), G6PC2(3), GCK(16), GRB2(2), GSK3B(3), GYS1(3), GYS2(24), HRAS(3), IKBKB(4), INPP5D(36), INSR(23), IRS1(5), IRS2(3), IRS4(11), KRAS(7), LIPE(10), MAP2K2(5), MAPK1(4), MAPK10(9), MAPK3(3), MAPK8(2), MAPK9(4), MKNK1(6), MKNK2(4), PCK1(25), PCK2(6), PDE3A(30), PDE3B(6), PDPK1(5), PFKL(3), PFKP(2), PHKA1(25), PHKA2(9), PHKB(10), PHKG1(3), PHKG2(3), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(3), PIK3R2(6), PIK3R3(2), PIK3R5(17), PKLR(14), PPARGC1A(26), PPP1CA(3), PPP1CB(5), PPP1CC(2), PPP1R3A(64), PPP1R3B(7), PPP1R3C(4), PPP1R3D(3), PRKAA1(1), PRKAA2(32), PRKAB1(2), PRKAB2(2), PRKACA(3), PRKACB(4), PRKACG(10), PRKAG1(3), PRKAG2(8), PRKAG3(11), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCI(8), PRKCZ(3), PRKX(3), PTPN1(4), PTPRF(35), PYGB(3), PYGL(9), PYGM(14), RAF1(11), RAPGEF1(14), RHEB(2), RHOQ(1), RPS6(1), RPS6KB1(4), RPS6KB2(2), SH2B2(4), SHC1(2), SHC2(7), SHC3(15), SHC4(4), SLC2A4(8), SOCS1(1), SOCS2(2), SOCS3(1), SOCS4(3), SORBS1(16), SOS1(10), SOS2(13), SREBF1(5), TRIP10(6), TSC1(9), TSC2(14)	66952032	1036	219	994	534	676	91	38	109	118	4	0.0652	1.000	1.000
71	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADA(3), ADCY1(34), ADCY2(10), ADCY3(3), ADCY4(5), ADCY5(19), ADCY6(9), ADCY7(13), ADCY8(54), ADCY9(11), ADK(5), ADSL(6), ADSS(2), ADSSL1(9), AK1(1), AK2(3), AK5(11), AK7(27), ALLC(8), AMPD1(34), AMPD2(8), AMPD3(29), APRT(3), ATIC(5), CANT1(11), DGUOK(4), ENPP1(13), ENPP3(14), ENTPD1(12), ENTPD2(4), ENTPD3(9), ENTPD4(3), ENTPD5(3), ENTPD6(4), ENTPD8(2), FHIT(2), GART(10), GDA(15), GMPR(2), GMPR2(1), GMPS(6), GUCY1A2(20), GUCY1A3(33), GUCY1B3(8), GUCY2C(38), GUCY2D(10), GUCY2F(21), GUK1(3), IMPDH1(4), ITPA(1), NME1(1), NME4(1), NME6(3), NME7(5), NPR1(17), NPR2(21), NT5C1A(6), NT5C1B(24), NT5C2(3), NT5E(6), NT5M(2), NUDT2(2), NUDT5(1), NUDT9(2), PAICS(1), PAPSS1(4), PAPSS2(5), PDE10A(13), PDE11A(20), PDE1A(44), PDE1C(54), PDE2A(16), PDE3B(6), PDE4A(10), PDE4B(8), PDE4C(19), PDE4D(7), PDE5A(9), PDE6D(2), PDE6G(2), PDE7A(1), PDE7B(17), PDE8A(3), PDE8B(22), PDE9A(12), PFAS(12), PKLR(14), PNPT1(2), POLA1(3), POLA2(9), POLD1(7), POLD2(2), POLD3(7), POLE(16), POLE2(2), POLR1A(13), POLR1B(8), POLR1C(1), POLR2A(13), POLR2B(14), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(2), POLR2H(2), POLR2J(2), POLR2L(1), POLR3A(8), POLR3B(15), POLR3G(1), POLR3GL(3), POLR3H(1), POLR3K(1), PRIM1(3), PRIM2(6), PRPS1(3), PRPS1L1(13), PRPS2(3), PRUNE(3), RRM1(3), RRM2(4), RRM2B(2), XDH(61)	69521955	1197	218	1136	613	816	94	53	111	121	2	0.00165	1.000	1.000
72	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	66	A2M(32), BDKRB1(6), BDKRB2(10), C1QA(6), C1QB(7), C1QC(10), C1R(16), C1S(20), C2(35), C3(55), C3AR1(6), C4BPA(16), C4BPB(6), C5(23), C5AR1(10), C6(72), C7(49), C8B(47), C8G(1), C9(22), CD46(1), CD55(6), CD59(1), CFB(20), CFH(50), CFI(18), CPB2(1), CR1(53), CR2(35), F10(8), F11(14), F12(1), F13A1(26), F13B(35), F2(13), F2R(8), F3(2), F5(39), F7(7), F8(49), F9(15), FGA(41), FGB(10), FGG(10), KLKB1(26), KNG1(14), MASP1(10), MASP2(11), MBL2(14), PLAT(5), PLAUR(4), PLG(36), PROC(11), PROS1(17), SERPINA1(9), SERPINA5(10), SERPINC1(7), SERPIND1(5), SERPINE1(6), SERPINF2(7), SERPING1(14), TFPI(7), THBD(2), VWF(59)	37951820	1186	218	1108	513	833	78	51	109	106	9	0.000147	1.000	1.000
73	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	83	ANPEP(25), CD14(6), CD19(8), CD1A(14), CD1B(14), CD1C(28), CD1D(10), CD1E(28), CD2(29), CD22(26), CD33(21), CD34(4), CD36(6), CD37(3), CD38(6), CD3D(7), CD3E(2), CD3G(1), CD4(9), CD44(5), CD5(8), CD55(6), CD59(1), CD7(2), CD8A(2), CD8B(9), CR1(53), CR2(35), CSF1(12), CSF1R(13), CSF2(2), CSF2RA(23), CSF3(4), CSF3R(10), DNTT(10), EPO(5), EPOR(1), FCER2(3), FCGR1A(6), FLT3(38), FLT3LG(1), GP5(6), GP9(6), HLA-DRA(13), HLA-DRB1(5), HLA-DRB5(1), IL11(3), IL11RA(3), IL1A(5), IL1B(8), IL1R1(12), IL1R2(7), IL2RA(7), IL3(3), IL3RA(8), IL4(1), IL4R(18), IL5(4), IL5RA(16), IL6(2), IL6R(3), IL7(5), IL7R(37), IL9R(6), ITGA1(23), ITGA2(13), ITGA2B(12), ITGA3(8), ITGA4(45), ITGA5(25), ITGA6(12), ITGAM(25), ITGB3(16), KIT(13), KITLG(10), MME(25), MS4A1(8), TFRC(4), THPO(10), TNF(1), TPO(47)	34627332	972	217	902	471	678	52	35	81	122	4	0.00485	1.000	1.000
74	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	79	AGL(18), AMY2A(7), AMY2B(14), ASCC3(16), ATP13A2(13), DDX18(5), DDX19A(1), DDX23(7), DDX4(13), DDX41(8), DDX47(1), DDX50(5), DDX51(5), DDX52(4), DDX54(3), DDX55(2), DDX56(3), DHX58(3), ENPP1(13), ENPP3(14), ENTPD7(2), EP400(28), ERCC2(3), ERCC3(6), G6PC(5), G6PC2(3), GAA(8), GANC(6), GBA(7), GBE1(9), GCK(16), GPI(3), GUSB(5), GYS1(3), GYS2(24), HK1(3), HK2(15), HK3(15), IFIH1(10), MGAM(169), MOV10L1(24), NUDT5(1), NUDT8(2), PGM1(6), PGM3(1), PYGB(3), PYGL(9), PYGM(14), RAD54B(8), RUVBL2(5), SETX(19), SI(94), SKIV2L2(6), SMARCA2(14), SMARCA5(5), TREH(2), UGDH(1), UGP2(1), UGT1A1(12), UGT1A10(18), UGT1A3(14), UGT1A4(10), UGT1A5(10), UGT1A6(15), UGT1A7(12), UGT1A9(16), UGT2A1(25), UGT2A3(32), UGT2B11(23), UGT2B15(31), UGT2B17(30), UGT2B28(29), UGT2B4(35), UGT2B7(19), UXS1(5)	51436338	1046	215	959	470	714	82	42	82	123	3	0.000226	1.000	1.000
75	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	108	ACTN1(8), ACTN2(21), ACTN4(5), ARHGAP5(13), BCAR1(5), CD99(1), CDC42(2), CDH5(12), CLDN1(5), CLDN10(8), CLDN11(5), CLDN14(5), CLDN15(1), CLDN16(7), CLDN17(5), CLDN18(11), CLDN19(2), CLDN2(6), CLDN20(1), CLDN22(2), CLDN3(3), CLDN4(12), CLDN6(9), CLDN7(1), CLDN8(4), CLDN9(1), CTNNA1(3), CTNNA2(28), CTNNA3(39), CTNNB1(17), CTNND1(9), CXCL12(2), CXCR4(3), CYBA(1), CYBB(8), ESAM(5), EZR(7), F11R(7), GNAI1(2), GNAI3(2), ICAM1(2), ITGA4(45), ITGAL(27), ITGAM(25), ITGB1(4), ITGB2(17), ITK(25), JAM2(11), JAM3(3), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MLLT4(17), MMP2(9), MMP9(8), MSN(2), MYL2(9), MYL5(1), MYL7(3), MYL9(2), NCF1(3), NCF2(8), NCF4(5), NOX1(13), NOX3(7), OCLN(6), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(3), PIK3R2(6), PIK3R3(2), PIK3R5(17), PLCG1(9), PLCG2(30), PRKCA(9), PRKCG(16), PTK2(7), PTK2B(12), PTPN11(10), PXN(2), RAC2(1), RAP1A(1), RAP1B(1), RAPGEF3(14), RAPGEF4(19), RASSF5(4), RHOA(2), RHOH(5), ROCK1(6), ROCK2(14), SIPA1(9), THY1(1), TXK(10), VASP(3), VAV1(19), VAV2(5), VAV3(11), VCAM1(17), VCL(9)	52152760	882	214	842	467	578	66	29	99	105	5	0.0228	1.000	1.000
76	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	69	ARAF(5), CACNA1A(38), CRHR1(7), GNA11(9), GNA12(3), GNA13(1), GNAI1(2), GNAI3(2), GNAO1(1), GNAQ(6), GNAS(33), GNAZ(7), GRIA1(47), GRIA2(43), GRIA3(26), GRID2(60), GRM1(13), GRM5(17), GUCY1A2(20), GUCY1A3(33), GUCY1B3(8), GUCY2C(38), GUCY2D(10), GUCY2F(21), HRAS(3), IGF1(11), IGF1R(15), ITPR1(36), ITPR2(20), ITPR3(12), KRAS(7), LYN(11), MAP2K2(5), MAPK1(4), MAPK3(3), NOS1(77), NOS3(20), NPR1(17), NPR2(21), PLA2G12B(3), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(19), PLA2G4A(16), PLA2G5(2), PLA2G6(13), PLCB1(58), PLCB2(12), PLCB3(4), PLCB4(87), PPP2CA(1), PPP2CB(2), PPP2R1A(4), PPP2R1B(5), PPP2R2A(5), PPP2R2B(6), PPP2R2C(8), PRKCA(9), PRKCG(16), PRKG1(14), PRKG2(16), RAF1(11), RYR1(114)	45089065	1156	214	1064	631	804	76	36	100	130	10	0.000809	1.000	1.000
77	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	68	ADH1A(17), ADH1B(30), ADH4(12), ADH5(3), ADH6(14), ADH7(16), ADHFE1(6), AKR1C1(2), AKR1C2(4), AKR1C3(12), AKR1C4(10), ALDH1A3(2), ALDH3A1(10), ALDH3B1(3), ALDH3B2(8), CYP1A1(10), CYP1A2(9), CYP1B1(4), CYP2B6(21), CYP2C18(34), CYP2C19(40), CYP2C8(32), CYP2C9(41), CYP2E1(14), CYP2F1(13), CYP2S1(14), CYP3A4(21), CYP3A43(19), CYP3A5(14), CYP3A7(18), DHDH(5), EPHX1(2), GSTA1(7), GSTA2(3), GSTA3(1), GSTA4(1), GSTA5(3), GSTK1(4), GSTM1(2), GSTM2(2), GSTM3(4), GSTM4(2), GSTM5(6), GSTO2(1), GSTP1(3), GSTT1(1), GSTZ1(1), MGST1(2), MGST2(2), MGST3(2), UGT1A1(12), UGT1A10(18), UGT1A3(14), UGT1A4(10), UGT1A5(10), UGT1A6(15), UGT1A7(12), UGT1A9(16), UGT2A1(25), UGT2A3(32), UGT2B11(23), UGT2B15(31), UGT2B17(30), UGT2B28(29), UGT2B4(35), UGT2B7(19)	23480328	838	211	752	365	598	52	37	53	95	3	2.85e-09	1.000	1.000
78	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(16), ABCA10(24), ABCA12(80), ABCA13(80), ABCA2(14), ABCA3(16), ABCA4(58), ABCA5(12), ABCA6(30), ABCA7(18), ABCA8(37), ABCA9(22), ABCB1(39), ABCB10(7), ABCB11(49), ABCB4(21), ABCB5(52), ABCB6(2), ABCB7(6), ABCB8(3), ABCB9(7), ABCC1(15), ABCC10(15), ABCC11(19), ABCC12(26), ABCC2(12), ABCC3(30), ABCC4(14), ABCC5(12), ABCC6(29), ABCC8(44), ABCC9(62), ABCD1(1), ABCD2(22), ABCD3(11), ABCD4(3), ABCG1(12), ABCG2(5), ABCG4(7), ABCG5(6), ABCG8(13), CFTR(62), TAP1(2), TAP2(7)	50128219	1022	210	961	581	673	82	34	108	119	6	0.00553	1.000	1.000
79	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	64	ADCY1(34), ADCY8(54), ARAF(5), ATF4(9), CACNA1C(60), CALM1(1), CALM2(1), CALML3(9), CALML6(1), CAMK2A(6), CAMK2B(6), CAMK2D(6), CAMK2G(5), CAMK4(17), CREBBP(24), EP300(19), GNAQ(6), GRIA1(47), GRIA2(43), GRIN1(8), GRIN2A(107), GRIN2B(59), GRIN2C(10), GRIN2D(11), GRM1(13), GRM5(17), HRAS(3), ITPR1(36), ITPR2(20), ITPR3(12), KRAS(7), MAP2K2(5), MAPK1(4), MAPK3(3), PLCB1(58), PLCB2(12), PLCB3(4), PLCB4(87), PPP1CA(3), PPP1CB(5), PPP1CC(2), PPP1R12A(4), PPP1R1A(4), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKACA(3), PRKACB(4), PRKACG(10), PRKCA(9), PRKCG(16), PRKX(3), RAF1(11), RAP1A(1), RAP1B(1), RAPGEF3(14), RPS6KA1(9), RPS6KA2(6), RPS6KA3(2), RPS6KA6(21)	40787458	968	210	900	578	646	82	39	95	100	6	0.256	1.000	1.000
80	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	88	AKT1(4), AKT3(3), BCAR1(5), CAPN1(5), CAPN10(7), CAPN11(10), CAPN2(6), CAPN3(9), CAPN5(6), CAPN6(14), CAPN7(2), CAPN9(12), CAPNS1(2), CAV1(1), CAV3(2), CDC42(2), CRK(3), CSK(1), DOCK1(17), FYN(8), GIT2(8), GRB2(2), ILK(2), ITGA10(12), ITGA11(19), ITGA2(13), ITGA2B(12), ITGA3(8), ITGA4(45), ITGA5(25), ITGA6(12), ITGA7(25), ITGA8(39), ITGA9(15), ITGAD(31), ITGAE(21), ITGAL(27), ITGAM(25), ITGAV(11), ITGAX(25), ITGB1(4), ITGB2(17), ITGB3(16), ITGB4(22), ITGB5(9), ITGB6(11), ITGB7(7), ITGB8(19), MAP2K2(5), MAP2K3(9), MAP2K6(3), MAPK10(9), MAPK12(1), MAPK4(17), MAPK6(8), MAPK7(4), MYLK2(13), PAK1(4), PAK2(9), PAK3(10), PAK4(8), PAK6(6), PDPK1(5), PIK3R2(6), PTK2(7), PXN(2), RAC2(1), RAP1B(1), RAPGEF1(14), RHO(2), ROCK1(6), ROCK2(14), SDCCAG8(3), SEPP1(3), SHC1(2), SHC3(15), SORBS1(16), SOS1(10), SRC(2), TLN1(12), TNS1(11), VASP(3), VAV2(5), VAV3(11), VCL(9), ZYX(8)	56054100	875	209	849	470	562	71	34	114	90	4	0.191	1.000	1.000
81	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	72	CALM1(1), CALM2(1), CALML3(9), CALML6(1), CDS1(11), CDS2(5), DGKA(3), DGKB(29), DGKD(13), DGKE(8), DGKG(18), DGKH(12), DGKI(36), DGKQ(7), DGKZ(9), IMPA1(1), IMPA2(5), INPP1(3), INPP4A(7), INPP4B(4), INPP5A(5), INPP5B(7), INPP5D(36), INPPL1(16), ITPK1(6), ITPKB(11), ITPR1(36), ITPR2(20), ITPR3(12), OCRL(7), PI4KA(22), PI4KB(8), PIK3C2A(8), PIK3C2B(16), PIK3C2G(56), PIK3C3(3), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(3), PIK3R2(6), PIK3R3(2), PIK3R5(17), PIP4K2A(6), PIP4K2B(3), PIP4K2C(2), PIP5K1A(6), PIP5K1B(21), PIP5K1C(9), PLCB1(58), PLCB2(12), PLCB3(4), PLCB4(87), PLCD1(3), PLCD3(4), PLCD4(5), PLCE1(56), PLCG1(9), PLCG2(30), PLCZ1(30), PRKCA(9), PRKCG(16), SYNJ1(23), SYNJ2(22)	52369739	951	208	879	458	665	50	38	82	110	6	0.000114	1.000	1.000
82	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	93	ADCY1(34), ADCY2(10), ADCY3(3), ADCY4(5), ADCY5(19), ADCY6(9), ADCY7(13), ADCY8(54), ADCY9(11), ATF4(9), CACNA1C(60), CACNA1D(36), CACNA1F(24), CACNA1S(54), CALM1(1), CALM2(1), CALML3(9), CALML6(1), CAMK2A(6), CAMK2B(6), CAMK2D(6), CAMK2G(5), CDC42(2), CGA(1), EGFR(25), ELK1(3), FSHB(9), GNA11(9), GNAQ(6), GNAS(33), GNRH2(2), GNRHR(2), GRB2(2), HBEGF(1), HRAS(3), ITPR1(36), ITPR2(20), ITPR3(12), JUN(1), KRAS(7), LHB(1), MAP2K2(5), MAP2K3(9), MAP2K4(4), MAP2K6(3), MAP2K7(5), MAP3K1(4), MAP3K2(8), MAP3K3(8), MAP3K4(19), MAPK1(4), MAPK10(9), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MAPK3(3), MAPK7(4), MAPK8(2), MAPK9(4), MMP14(3), MMP2(9), PLA2G12B(3), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(19), PLA2G4A(16), PLA2G5(2), PLA2G6(13), PLCB1(58), PLCB2(12), PLCB3(4), PLCB4(87), PLD1(14), PLD2(8), PRKACA(3), PRKACB(4), PRKACG(10), PRKCA(9), PRKCD(5), PRKX(3), PTK2B(12), RAF1(11), SOS1(10), SOS2(13), SRC(2)	53196332	1003	207	947	625	647	95	46	97	113	5	0.378	1.000	1.000
83	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	96	ADCY1(34), ADCY2(10), ADCY3(3), ADCY4(5), ADCY5(19), ADCY6(9), ADCY7(13), ADCY8(54), ADCY9(11), ASIP(1), CALM1(1), CALM2(1), CALML3(9), CALML6(1), CAMK2A(6), CAMK2B(6), CAMK2D(6), CAMK2G(5), CREB3L1(7), CREB3L2(11), CREB3L3(10), CREB3L4(7), CREBBP(24), CTNNB1(17), DCT(4), DVL1(1), DVL2(3), DVL3(9), EDN1(9), EDNRB(7), EP300(19), FZD1(5), FZD10(4), FZD2(7), FZD3(1), FZD4(1), FZD5(2), FZD6(2), FZD7(5), FZD8(6), FZD9(1), GNAI1(2), GNAI3(2), GNAO1(1), GNAQ(6), GNAS(33), GSK3B(3), HRAS(3), KIT(13), KITLG(10), KRAS(7), LEF1(3), MAP2K2(5), MAPK1(4), MAPK3(3), MC1R(1), MITF(6), PLCB1(58), PLCB2(12), PLCB3(4), PLCB4(87), POMC(4), PRKACA(3), PRKACB(4), PRKACG(10), PRKCA(9), PRKCG(16), PRKX(3), RAF1(11), TCF7(1), TCF7L1(4), TCF7L2(7), TYR(11), TYRP1(9), WNT1(2), WNT10A(7), WNT10B(6), WNT11(4), WNT16(4), WNT2(8), WNT2B(5), WNT3(5), WNT3A(8), WNT4(1), WNT5A(5), WNT5B(5), WNT6(3), WNT7A(13), WNT7B(6), WNT8A(6), WNT8B(8), WNT9A(4), WNT9B(6)	45263851	817	204	766	458	509	80	46	86	92	4	0.0603	1.000	1.000
84	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	74	ACP1(4), ACTB(9), ACTG1(7), ACTN1(8), ACTN2(21), ACTN4(5), ACVR1B(3), ACVR1C(10), BAIAP2(8), CDC42(2), CDH1(6), CREBBP(24), CSNK2A1(2), CSNK2A2(1), CSNK2B(1), CTNNA1(3), CTNNA2(28), CTNNA3(39), CTNNB1(17), CTNND1(9), EGFR(25), EP300(19), ERBB2(10), FARP2(7), FER(3), FGFR1(12), FYN(8), IGF1R(15), INSR(23), IQGAP1(10), LEF1(3), LMO7(30), MAP3K7(1), MAPK1(4), MAPK3(3), MET(23), MLLT4(17), NLK(5), PARD3(20), PTPN1(4), PTPN6(5), PTPRB(84), PTPRF(35), PTPRJ(9), PTPRM(8), PVRL1(4), PVRL2(6), PVRL3(5), PVRL4(10), RAC2(1), RHOA(2), SMAD2(4), SMAD3(4), SMAD4(2), SNAI1(2), SNAI2(4), SORBS1(16), SRC(2), SSX2IP(4), TCF7(1), TCF7L1(4), TCF7L2(7), TGFBR2(9), TJP1(16), VCL(9), WAS(8), WASF1(5), WASF2(6), WASF3(14), WASL(4), YES1(4)	50962794	743	201	707	377	483	64	32	77	82	5	0.263	1.000	1.000
85	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	108	A4GNT(2), ALG1(4), ALG10(6), ALG10B(4), ALG11(5), ALG12(1), ALG13(10), ALG14(2), ALG2(5), ALG3(4), ALG6(2), ALG8(7), ALG9(5), B3GNT1(3), B3GNT2(2), B3GNT6(2), B3GNT7(6), B4GALT1(2), B4GALT2(2), B4GALT3(3), B4GALT4(3), B4GALT5(3), C1GALT1(7), C1GALT1C1(3), CHPF(4), CHST1(11), CHST11(7), CHST12(7), CHST13(3), CHST14(3), CHST2(5), CHST3(2), CHST4(10), CHST6(4), CHST7(3), CHSY1(9), DAD1(1), DDOST(2), DPAGT1(2), EXT1(2), EXT2(9), EXTL1(4), EXTL3(13), FUT11(4), FUT8(8), GALNT1(4), GALNT10(7), GALNT11(3), GALNT12(8), GALNT13(31), GALNT14(30), GALNT2(7), GALNT3(4), GALNT4(5), GALNT5(13), GALNT6(16), GALNT7(4), GALNT8(28), GALNT9(7), GALNTL5(17), GANAB(6), GCNT1(6), GCNT3(8), GCNT4(3), HS2ST1(1), HS3ST1(11), HS3ST2(8), HS3ST3A1(6), HS3ST3B1(1), HS3ST5(9), HS6ST1(2), HS6ST2(3), HS6ST3(15), MAN1A1(19), MAN1A2(7), MAN1B1(4), MAN1C1(11), MAN2A1(10), MGAT1(3), MGAT2(3), MGAT3(12), MGAT4A(8), MGAT4B(1), MGAT5(6), MGAT5B(11), NDST1(6), NDST2(2), NDST3(25), NDST4(51), OGT(9), RPN2(4), ST3GAL1(8), ST3GAL2(1), ST3GAL3(2), ST3GAL4(1), ST6GAL1(8), ST6GALNAC1(8), STT3B(5), WBSCR17(46), XYLT1(12), XYLT2(5)	46699723	757	200	727	406	486	64	34	77	96	0	0.0611	1.000	1.000
86	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	107	ABL1(15), ANAPC1(18), ANAPC10(1), ANAPC2(7), ANAPC4(6), ANAPC5(5), ANAPC7(6), ATM(16), ATR(22), BUB1(6), BUB1B(10), BUB3(1), CCNA1(16), CCNB2(2), CCNB3(31), CCND1(2), CCND2(7), CCND3(2), CCNE1(4), CCNE2(6), CCNH(1), CDC14A(6), CDC14B(3), CDC20(1), CDC23(4), CDC25A(8), CDC25B(4), CDC25C(5), CDC27(14), CDC6(2), CDC7(3), CDK2(1), CDK6(2), CDK7(2), CDKN1A(3), CDKN1B(1), CDKN2C(1), CHEK1(2), CHEK2(2), CREBBP(24), CUL1(3), DBF4(6), E2F1(6), E2F2(5), E2F3(4), EP300(19), ESPL1(19), FZR1(8), GADD45B(2), GSK3B(3), HDAC1(2), HDAC2(2), MAD1L1(6), MAD2L1(1), MAD2L2(2), MCM2(11), MCM3(9), MCM4(8), MCM5(5), MCM6(5), MCM7(1), MDM2(4), PCNA(2), PKMYT1(3), PLK1(4), PRKDC(22), PTTG1(1), RB1(10), RBL1(14), RBL2(6), SFN(2), SKP2(2), SMAD2(4), SMAD3(4), SMAD4(2), SMC1A(3), SMC1B(25), TFDP1(2), TGFB1(2), TGFB2(3), TGFB3(3), WEE1(2), YWHAB(1), YWHAE(2), YWHAG(2), YWHAQ(3)	57189963	527	199	518	241	304	48	36	81	56	2	0.193	1.000	1.000
87	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	75	ABL1(15), ACTN1(8), ACTR2(3), ACTR3(2), AKT1(4), AKT2(8), AKT3(3), ANGPTL2(3), ARHGEF6(11), ARHGEF7(5), BCAR1(5), CAV1(1), CDC42(2), CRK(3), CSE1L(5), DOCK1(17), EPHB2(36), FYN(8), GRB2(2), GRB7(9), ILK(2), ITGA1(23), ITGA10(12), ITGA11(19), ITGA2(13), ITGA3(8), ITGA4(45), ITGA5(25), ITGA6(12), ITGA7(25), ITGA8(39), ITGA9(15), ITGB3BP(3), MAP2K4(4), MAP2K7(5), MAP3K11(6), MAPK1(4), MAPK10(9), MAPK8(2), MAPK8IP1(7), MAPK8IP2(8), MAPK8IP3(9), MAPK9(4), MRAS(2), MYLK(48), MYLK2(13), P4HB(3), PAK1(4), PAK2(9), PAK3(10), PAK4(8), PAK6(6), PAK7(55), PIK3CA(10), PIK3CB(10), PKLR(14), PLCG1(9), PLCG2(30), PTK2(7), RAF1(11), RALA(1), RHO(2), ROCK1(6), ROCK2(14), SHC1(2), SOS1(10), SOS2(13), SRC(2), TERF2IP(2), TLN1(12), TLN2(27), VASP(3), WAS(8), ZYX(8)	50580065	808	199	768	415	517	68	29	108	84	2	0.129	1.000	1.000
88	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	90	ADCY1(34), ADCY2(10), ADCY3(3), ADCY4(5), ADCY5(19), ADCY6(9), ADCY7(13), ADCY8(54), ADCY9(11), AKAP1(12), AKAP10(3), AKAP11(12), AKAP12(6), AKAP2(2), AKAP3(17), AKAP4(19), AKAP6(41), AKAP7(3), AKAP8(7), AKAP9(37), ARHGEF1(1), CALM1(1), CALM2(1), CHMP1B(1), GNA11(9), GNA12(3), GNA13(1), GNA14(7), GNA15(7), GNAI3(2), GNAL(2), GNAO1(1), GNAQ(6), GNAZ(7), GNB1(1), GNB2(1), GNB3(7), GNB5(2), GNG10(1), GNG4(3), GNG7(2), GNGT2(5), HRAS(3), ITPR1(36), KCNJ3(21), KRAS(7), PALM2(3), PDE1A(44), PDE1B(15), PDE1C(54), PDE4A(10), PDE4B(8), PDE4C(19), PDE4D(7), PDE7A(1), PDE7B(17), PDE8A(3), PDE8B(22), PLCB3(4), PPP3CA(5), PPP3CC(2), PRKACA(3), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCA(9), PRKCD(5), PRKCE(7), PRKCG(16), PRKCH(9), PRKCI(8), PRKCQ(21), PRKCZ(3), PRKD1(9), PRKD3(9), RHOA(2), RRAS(1), SLC9A1(5), USP5(8)	49261196	811	198	773	493	556	60	37	76	82	0	0.645	1.000	1.000
89	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADA(3), ADCY1(34), ADCY2(10), ADCY3(3), ADCY4(5), ADCY5(19), ADCY6(9), ADCY7(13), ADCY8(54), ADK(5), ADSL(6), ADSS(2), AK1(1), AK2(3), AK5(11), ALLC(8), AMPD1(34), AMPD2(8), AMPD3(29), APRT(3), ATIC(5), ATP1B1(2), ATP5A1(2), ATP5B(1), ATP5C1(3), ATP5F1(7), ATP5G2(2), ATP5H(2), ATP5J(2), CANT1(11), DGUOK(4), ENPP1(13), ENPP3(14), ENTPD1(12), ENTPD2(4), FHIT(2), GART(10), GDA(15), GMPS(6), GUCY1A2(20), GUCY1A3(33), GUCY1B3(8), GUCY2C(38), GUCY2D(10), GUCY2F(21), GUK1(3), IMPDH1(4), ITPA(1), NME1(1), NPR1(17), NPR2(21), NT5E(6), NT5M(2), NUDT2(2), PAICS(1), PAPSS1(4), PAPSS2(5), PDE1A(44), PDE4A(10), PDE4B(8), PDE4C(19), PDE4D(7), PDE5A(9), PDE6B(16), PDE6C(25), PDE6G(2), PDE7B(17), PDE8A(3), PDE9A(12), PFAS(12), PKLR(14), POLB(1), POLD1(7), POLD2(2), POLE(16), POLG(8), POLL(10), POLQ(26), POLR1B(8), POLR2A(13), POLR2B(14), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(2), POLR2H(2), POLR2J(2), POLR2L(1), POLRMT(4), PRPS1(3), PRPS1L1(13), PRPS2(3), PRUNE(3), RRM1(3), RRM2(4)	54462095	920	197	864	484	625	74	33	90	96	2	0.00771	1.000	1.000
90	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	96	AKT1(4), AKT2(8), AKT3(3), CASP8(9), CD14(6), CD40(4), CD80(4), CD86(25), CHUK(2), CXCL10(3), CXCL11(1), CXCL9(2), FOS(2), IFNA1(1), IFNA10(2), IFNA13(1), IFNA14(8), IFNA16(11), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA5(4), IFNA6(3), IFNA7(6), IFNA8(3), IFNAR1(3), IFNAR2(8), IFNB1(6), IKBKB(4), IKBKE(9), IL12A(4), IL12B(3), IL1B(8), IL6(2), IRAK1(5), IRAK4(3), IRF3(3), IRF5(5), IRF7(5), JUN(1), LBP(10), LY96(4), MAP2K2(5), MAP2K3(9), MAP2K4(4), MAP2K6(3), MAP2K7(5), MAP3K7(1), MAPK1(4), MAPK10(9), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MAPK3(3), MAPK8(2), MAPK9(4), MYD88(1), NFKB1(6), NFKB2(5), NFKBIA(2), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(3), PIK3R2(6), PIK3R3(2), PIK3R5(17), RELA(4), RIPK1(3), SPP1(7), STAT1(5), TBK1(3), TICAM1(8), TIRAP(1), TLR1(15), TLR2(15), TLR3(11), TLR4(42), TLR5(22), TLR6(7), TLR7(17), TLR8(14), TLR9(14), TNF(1), TOLLIP(1), TRAF3(5), TRAF6(4)	37641714	564	195	544	292	365	40	27	69	61	2	0.0717	1.000	1.000
91	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	90	AKT1(4), AKT2(8), AKT3(3), BCL10(3), CARD11(41), CBL(10), CBLB(21), CBLC(16), CD247(4), CD28(2), CD3D(7), CD3E(2), CD3G(1), CD4(9), CD40LG(1), CD8A(2), CD8B(9), CDC42(2), CHUK(2), CSF2(2), CTLA4(2), FOS(2), FYN(8), GRAP2(6), GRB2(2), HRAS(3), ICOS(3), IFNG(4), IKBKB(4), IL10(2), IL2(4), IL4(1), IL5(4), ITK(25), JUN(1), KRAS(7), LAT(3), LCK(15), LCP2(8), MALT1(8), NCK1(2), NCK2(4), NFAT5(11), NFATC1(17), NFATC2(12), NFATC3(11), NFATC4(18), NFKB1(6), NFKB2(5), NFKBIA(2), NFKBIB(1), PAK1(4), PAK2(9), PAK3(10), PAK4(8), PAK6(6), PAK7(55), PDCD1(4), PDK1(2), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(3), PIK3R2(6), PIK3R3(2), PIK3R5(17), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKCQ(21), PTPN6(5), PTPRC(36), RASGRP1(11), RHOA(2), SOS1(10), SOS2(13), TEC(13), TNF(1), VAV1(19), VAV2(5), VAV3(11), ZAP70(8)	42739556	707	194	675	347	444	57	28	85	88	5	0.160	1.000	1.000
92	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(18), AMY2A(7), AMY2B(14), ENPP1(13), ENPP3(14), G6PC(5), GAA(8), GANAB(6), GBE1(9), GCK(16), GPI(3), GUSB(5), GYS1(3), GYS2(24), HK1(3), HK2(15), HK3(15), MGAM(169), PGM1(6), PGM3(1), PYGB(3), PYGL(9), PYGM(14), SI(94), UCHL1(5), UCHL3(2), UGDH(1), UGT1A1(12), UGT1A10(18), UGT1A3(14), UGT1A4(10), UGT1A5(10), UGT1A6(15), UGT1A7(12), UGT1A9(16), UGT2B15(31), UGT2B4(35), UXS1(5)	24148111	660	193	598	290	460	61	26	47	64	2	0.000238	1.000	1.000
93	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	88	ACVR1(2), ACVR1B(3), ACVR1C(10), ACVR2A(5), ACVR2B(3), ACVRL1(11), AMHR2(15), BMP2(7), BMP4(5), BMP5(33), BMP6(12), BMP7(5), BMP8A(2), BMP8B(1), BMPR1A(2), BMPR1B(4), BMPR2(7), CHRD(21), COMP(8), CREBBP(24), CUL1(3), DCN(19), E2F4(3), E2F5(3), EP300(19), FST(5), GDF5(16), GDF6(2), GDF7(1), ID1(1), ID2(2), IFNG(4), INHBA(20), INHBB(9), INHBC(13), INHBE(5), LEFTY1(7), LEFTY2(4), LTBP1(46), MAPK1(4), MAPK3(3), MYC(5), NODAL(2), NOG(2), PITX2(6), PPP2CA(1), PPP2CB(2), PPP2R1A(4), PPP2R1B(5), PPP2R2A(5), PPP2R2B(6), PPP2R2C(8), RBL1(14), RBL2(6), RHOA(2), ROCK1(6), ROCK2(14), RPS6KB1(4), RPS6KB2(2), SMAD1(5), SMAD2(4), SMAD3(4), SMAD4(2), SMAD5(2), SMAD6(7), SMAD7(1), SMAD9(12), SMURF1(2), SMURF2(9), SP1(5), TFDP1(2), TGFB1(2), TGFB2(3), TGFB3(3), TGFBR2(9), THBS1(31), THBS2(14), THBS3(12), THBS4(19), TNF(1), ZFYVE16(7), ZFYVE9(8)	42268096	627	192	598	290	396	60	30	62	79	0	0.0723	1.000	1.000
94	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	122	ARAF(5), CASP3(2), CD244(10), CD247(4), CD48(5), CSF2(2), FAS(5), FASLG(15), FCER1G(1), FCGR3A(9), FYN(8), GRB2(2), GZMB(3), HLA-A(4), HLA-B(6), HLA-C(2), HLA-E(1), HLA-G(5), HRAS(3), ICAM1(2), ICAM2(4), IFNA1(1), IFNA10(2), IFNA13(1), IFNA14(8), IFNA16(11), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA5(4), IFNA6(3), IFNA7(6), IFNA8(3), IFNAR1(3), IFNAR2(8), IFNB1(6), IFNG(4), IFNGR1(3), IFNGR2(4), ITGAL(27), ITGB2(17), KIR2DL3(5), KIR3DL1(14), KIR3DL2(16), KLRC1(4), KLRC2(1), KLRC3(12), KLRD1(7), KLRK1(7), KRAS(7), LAT(3), LCK(15), LCP2(8), MAP2K2(5), MAPK1(4), MAPK3(3), MICA(4), MICB(7), NCR1(18), NCR2(14), NCR3(5), NFAT5(11), NFATC1(17), NFATC2(12), NFATC3(11), NFATC4(18), PAK1(4), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(3), PIK3R2(6), PIK3R3(2), PIK3R5(17), PLCG1(9), PLCG2(30), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRF1(14), PRKCA(9), PRKCG(16), PTK2B(12), PTPN11(10), PTPN6(5), RAC2(1), RAF1(11), SH2D1A(3), SH2D1B(5), SH3BP2(2), SHC1(2), SHC2(7), SHC3(15), SHC4(4), SOS1(10), SOS2(13), SYK(15), TNF(1), TNFRSF10A(7), TNFRSF10B(5), TNFRSF10C(4), TNFRSF10D(9), TNFSF10(9), TYROBP(4), ULBP1(2), ULBP2(1), ULBP3(6), VAV1(19), VAV2(5), VAV3(11), ZAP70(8)	46774121	831	192	796	434	529	67	31	95	105	4	0.168	1.000	1.000
95	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(66), COL4A2(36), COL4A3(50), COL4A4(122), COL4A5(68), COL4A6(43), F10(8), F11(14), F12(1), F2(13), F2R(8), F5(39), F8(49), F9(15), FGA(41), FGB(10), FGG(10), KLKB1(26), PROC(11), PROS1(17), SERPINC1(7), SERPING1(14)	18897075	668	190	619	185	498	40	19	54	52	5	0.00111	1.000	1.000
96	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	81	ABL1(15), ABL2(12), AKT1(4), AKT2(8), AKT3(3), ARAF(5), BTC(2), CAMK2A(6), CAMK2B(6), CAMK2D(6), CAMK2G(5), CBL(10), CBLB(21), CBLC(16), CDKN1A(3), CDKN1B(1), CRK(3), CRKL(2), EGF(22), EGFR(25), EIF4EBP1(1), ELK1(3), ERBB2(10), ERBB3(5), ERBB4(59), EREG(4), GAB1(8), GRB2(2), GSK3B(3), HBEGF(1), HRAS(3), JUN(1), KRAS(7), MAP2K2(5), MAP2K4(4), MAP2K7(5), MAPK1(4), MAPK10(9), MAPK3(3), MAPK8(2), MAPK9(4), MYC(5), NCK1(2), NCK2(4), NRG1(16), NRG2(9), NRG3(24), NRG4(1), PAK1(4), PAK2(9), PAK3(10), PAK4(8), PAK6(6), PAK7(55), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(3), PIK3R2(6), PIK3R3(2), PIK3R5(17), PLCG1(9), PLCG2(30), PRKCA(9), PRKCG(16), PTK2(7), RAF1(11), RPS6KB1(4), RPS6KB2(2), SHC1(2), SHC2(7), SHC3(15), SHC4(4), SOS1(10), SOS2(13), SRC(2), STAT5A(3), STAT5B(5), TGFA(2)	42394150	706	189	673	353	441	61	29	86	87	2	0.214	1.000	1.000
97	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR1(10), AGTR2(10), ATP8A1(32), AVPR1A(4), AVPR1B(13), BDKRB1(6), BDKRB2(10), BRS3(5), C3AR1(6), CCKAR(12), CCKBR(11), CCR1(10), CCR10(2), CCR2(17), CCR3(11), CCR4(9), CCR5(10), CCR6(4), CCR7(4), CCR8(8), CX3CR1(16), CXCR3(4), CXCR4(3), CXCR6(6), EDNRA(11), EDNRB(7), FPR1(22), FSHR(21), GALR1(5), GALR3(2), GALT(2), GHSR(11), GNB2L1(4), GNRHR(2), GRPR(7), LHCGR(29), MC1R(1), MC2R(5), MC3R(7), MC4R(1), MC5R(8), NMBR(8), NPY1R(29), NPY2R(13), NPY5R(25), NTSR1(8), NTSR2(2), OPRD1(3), OPRK1(23), OPRL1(8), OPRM1(5), OXTR(6), SSTR1(10), SSTR2(7), SSTR3(13), SSTR4(4), TACR1(8), TACR2(9), TACR3(29), TRHR(24), TSHR(8)	22324664	610	189	572	420	422	53	26	58	51	0	0.00126	1.000	1.000
98	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	82	ACVR1(2), ACVR1B(3), ACVRL1(11), AKT1(4), AURKB(2), BMPR1A(2), BMPR2(7), BUB1(6), CDKL1(1), CDKL2(2), CDS1(11), CDS2(5), CLK1(5), CLK2(8), COL4A3BP(3), CSNK2A1(2), CSNK2A2(1), CSNK2B(1), DGKA(3), DGKB(29), DGKD(13), DGKE(8), DGKG(18), DGKH(12), DGKQ(7), DGKZ(9), IMPA1(1), INPP1(3), INPP4A(7), INPP4B(4), INPP5A(5), INPPL1(16), ITPKB(11), MAP3K10(13), MOS(6), NEK1(7), NEK3(2), OCRL(7), PAK4(8), PIK3C2A(8), PIK3C2B(16), PIK3C2G(56), PIK3CA(10), PIK3CB(10), PIK3CG(28), PIM2(5), PLCB1(58), PLCB2(12), PLCB3(4), PLCB4(87), PLCD1(3), PLCG1(9), PLCG2(30), PLK3(3), PRKACA(3), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCA(9), PRKCD(5), PRKCE(7), PRKCG(16), PRKCH(9), PRKCQ(21), PRKCZ(3), PRKD1(9), PRKG1(14), RAF1(11), RPS6KA1(9), RPS6KA2(6), RPS6KA3(2), RPS6KA4(4), RPS6KB1(4), STK11(4), VRK1(1)	47819286	768	187	713	418	523	47	26	76	92	4	0.415	1.000	1.000
99	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	AANAT(1), ACAT2(1), ACMSD(13), ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(6), ALDH3A1(10), ALDH3A2(3), ALDH9A1(3), AOC2(9), AOC3(9), AOX1(29), ASMT(8), CAT(8), CYP19A1(15), CYP1A1(10), CYP1A2(9), CYP2A13(13), CYP2A6(11), CYP2A7(9), CYP2B6(21), CYP2C18(34), CYP2C19(40), CYP2C8(32), CYP2C9(41), CYP2D6(3), CYP2E1(14), CYP2F1(13), CYP2J2(8), CYP3A4(21), CYP3A5(14), CYP3A7(18), CYP4B1(27), CYP51A1(1), DDC(16), ECHS1(3), EHHADH(6), GCDH(6), HAAO(3), HADHA(6), KMO(7), KYNU(16), MAOA(4), MAOB(13), SDS(3), TDO2(4), TPH1(12), WARS(5), WARS2(4)	23386276	598	187	563	341	430	38	20	44	63	3	0.0633	1.000	1.000
100	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	53	AKR1C4(10), AKR1D1(21), ARSD(3), ARSE(5), CARM1(7), CYP11B1(17), CYP11B2(12), CYP19A1(15), HEMK1(4), HSD11B1(14), HSD11B2(2), HSD17B12(4), HSD17B2(13), HSD17B3(5), HSD17B7(1), HSD3B1(15), HSD3B2(14), LCMT1(4), LCMT2(1), METTL2B(5), METTL6(2), PRMT2(2), PRMT3(5), PRMT5(7), PRMT7(4), PRMT8(10), SRD5A1(2), STS(7), SULT1E1(16), SULT2A1(9), SULT2B1(6), UGT1A1(12), UGT1A10(18), UGT1A3(14), UGT1A4(10), UGT1A5(10), UGT1A6(15), UGT1A7(12), UGT1A9(16), UGT2A1(25), UGT2A3(32), UGT2B11(23), UGT2B15(31), UGT2B17(30), UGT2B28(29), UGT2B4(35), UGT2B7(19), WBSCR22(2)	20369587	575	180	517	236	389	54	21	40	69	2	2.51e-07	1.000	1.000
101	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	54	ADH1A(17), ADH1B(30), ADH4(12), ADH5(3), ADH6(14), ADH7(16), ADHFE1(6), AGK(8), AGPAT1(1), AGPAT2(3), AGPAT3(5), AGPAT4(6), AGPAT6(3), AKR1A1(4), AKR1B1(2), ALDH1A3(2), ALDH1B1(11), ALDH2(6), ALDH3A1(10), ALDH3A2(3), ALDH7A1(10), ALDH9A1(3), CEL(13), DAK(4), DGAT1(1), DGAT2(7), DGKA(3), DGKB(29), DGKD(13), DGKE(8), DGKG(18), DGKH(12), DGKI(36), DGKQ(7), DGKZ(9), GK(7), GLA(2), GLB1(10), GPAM(6), LCT(54), LIPA(5), LIPC(10), LIPF(17), LIPG(10), LPL(6), MGLL(9), PNLIP(9), PNLIPRP1(10), PNPLA3(3), PPAP2B(11), PPAP2C(8)	24538582	512	180	469	228	343	47	21	51	48	2	0.000151	1.000	1.000
102	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	92	ACTB(9), BCL2(3), CABIN1(17), CALM1(1), CALM2(1), CAMK2B(6), CAMK4(17), CD3E(2), CD3G(1), CD69(4), CDKN1A(3), CNR1(12), CREBBP(24), CSF2(2), CSNK2A1(2), CSNK2B(1), CTLA4(2), EGR2(5), EGR3(4), EP300(19), FCER1A(17), FCGR3A(9), FOS(2), GATA3(9), GATA4(5), GSK3A(1), GSK3B(3), HRAS(3), ICOS(3), IFNA1(1), IFNB1(6), IFNG(4), IL10(2), IL13(2), IL1B(8), IL2(4), IL2RA(7), IL3(3), IL4(1), IL6(2), ITK(25), KPNA5(2), MAP2K7(5), MAPK14(5), MAPK8(2), MAPK9(4), MEF2A(3), MEF2B(2), MEF2D(6), MYF5(16), NCK2(4), NFAT5(11), NFATC1(17), NFATC2(12), NFATC3(11), NFATC4(18), NFKB2(5), NFKBIB(1), NPPB(6), NUP214(15), OPRD1(3), P2RX7(4), PAK1(4), PIN1(1), PPIA(1), PPP3CB(4), PPP3CC(2), PTPRC(36), RELA(4), RPL13A(2), SFN(2), SLA(3), SP1(5), SP3(1), TGFB1(2), TNF(1), TRAF2(2), TRPV6(30), VAV1(19), VAV2(5), VAV3(11), XPO5(8)	38810128	547	179	525	307	359	39	23	49	72	5	0.626	1.000	1.000
103	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	52	ADORA3(12), ALG6(2), CCKBR(11), CCR2(17), CCR3(11), CCR5(10), CELSR1(31), CELSR2(26), CELSR3(32), CHRM2(26), CHRM3(26), CXCR3(4), DRD4(1), EDNRA(11), EMR2(6), EMR3(22), F2R(8), FSHR(21), GHRHR(6), GNRHR(2), GPR116(38), GPR132(3), GPR133(14), GPR143(4), GPR17(1), GPR18(5), GPR55(6), GPR56(4), GPR61(7), GPR84(9), GRM1(13), GRPR(7), HRH4(6), LGR6(22), LPHN2(49), LPHN3(24), LTB4R2(1), NTSR1(8), OR2M4(14), P2RY11(2), P2RY13(4), PTGFR(21), SMO(10), SSTR2(7), TAAR5(4), TSHR(8), VN1R1(1)	28348932	577	178	547	383	376	50	26	61	62	2	0.185	1.000	1.000
104	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ADCY4(5), ADCY6(9), ADCY8(54), CACNA1A(38), CACNA1B(38), GNAS(33), GNAT3(5), GNB1(1), GNB3(7), GRM4(22), ITPR3(12), KCNB1(37), PDE1A(44), PLCB2(12), PRKACA(3), PRKACB(4), PRKACG(10), PRKX(3), SCNN1A(10), SCNN1B(16), SCNN1G(33), TAS1R1(14), TAS1R2(23), TAS1R3(2), TAS2R1(8), TAS2R10(8), TAS2R13(2), TAS2R14(5), TAS2R16(10), TAS2R3(2), TAS2R38(19), TAS2R39(14), TAS2R4(4), TAS2R40(4), TAS2R41(13), TAS2R42(2), TAS2R43(2), TAS2R46(3), TAS2R5(4), TAS2R50(2), TAS2R60(20), TAS2R7(5), TAS2R8(5), TAS2R9(10), TRPM5(13)	24119177	590	178	551	471	394	43	28	60	62	3	0.866	1.000	1.000
105	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	60	AKT1(4), AKT2(8), AKT3(3), BCL10(3), BLNK(15), BTK(15), CARD11(41), CD19(8), CD22(26), CD72(5), CD79A(4), CD81(3), CHUK(2), CR2(35), FCGR2B(3), FOS(2), GSK3B(3), HRAS(3), IKBKB(4), INPP5D(36), JUN(1), KRAS(7), LILRB3(4), LYN(11), MALT1(8), NFAT5(11), NFATC1(17), NFATC2(12), NFATC3(11), NFATC4(18), NFKB1(6), NFKB2(5), NFKBIA(2), NFKBIB(1), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(3), PIK3R2(6), PIK3R3(2), PIK3R5(17), PLCG2(30), PPP3CA(5), PPP3CB(4), PPP3CC(2), PTPN6(5), RAC2(1), RASGRP3(12), SYK(15), VAV1(19), VAV2(5), VAV3(11)	31376463	530	177	510	248	334	35	27	60	67	7	0.0209	1.000	1.000
106	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	46	IMPA1(1), IMPA2(5), INPP1(3), INPP4A(7), INPP4B(4), INPP5A(5), INPP5B(7), INPPL1(16), IPMK(2), ISYNA1(1), ITPK1(6), ITPKB(11), MINPP1(1), MIOX(5), OCRL(7), PI4KA(22), PI4KB(8), PIK3C3(3), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIP4K2A(6), PIP4K2B(3), PIP4K2C(2), PIP5K1A(6), PIP5K1B(21), PIP5K1C(9), PLCB1(58), PLCB2(12), PLCB3(4), PLCB4(87), PLCD1(3), PLCD3(4), PLCD4(5), PLCE1(56), PLCG1(9), PLCG2(30), PLCZ1(30), SYNJ1(23), SYNJ2(22)	31106789	560	176	526	264	383	30	27	53	64	3	0.00161	1.000	1.000
107	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	66	ACAA1(6), ACADL(5), ACADM(5), ACOX1(8), ACOX2(6), ACOX3(13), ACSL1(8), ACSL3(8), ACSL4(5), ACSL5(22), ACSL6(13), ADIPOQ(5), ANGPTL4(5), APOA1(1), APOA5(5), APOC3(2), AQP7(5), CD36(6), CPT1A(14), CPT1B(9), CPT1C(18), CPT2(2), CYP27A1(4), CYP4A11(29), CYP4A22(23), CYP7A1(8), CYP8B1(13), DBI(1), EHHADH(6), FABP1(6), FABP2(7), FABP3(1), FABP4(2), FABP7(1), FADS2(4), GK(7), HMGCS2(18), ILK(2), LPL(6), ME1(22), MMP1(14), NR1H3(4), OLR1(6), PCK1(25), PCK2(6), PDPK1(5), PLTP(1), PPARA(8), PPARD(3), PPARG(12), RXRA(4), RXRB(4), RXRG(6), SCD(4), SCP2(4), SLC27A1(3), SLC27A2(16), SLC27A4(5), SLC27A5(10), SLC27A6(34), SORBS1(16), UBC(6), UCP1(5)	27471534	532	176	498	299	358	53	20	38	60	3	0.246	1.000	1.000
108	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	79	ABL1(15), ATM(16), BUB1(6), BUB1B(10), BUB3(1), CCNA1(16), CCNB2(2), CCNB3(31), CCND2(7), CCND3(2), CCNE1(4), CCNE2(6), CCNH(1), CDAN1(6), CDC14A(6), CDC14B(3), CDC20(1), CDC25A(8), CDC25B(4), CDC25C(5), CDC6(2), CDC7(3), CDH1(6), CDK2(1), CDKN1A(3), CHEK1(2), CHEK2(2), DTX4(4), E2F1(6), E2F2(5), E2F3(4), E2F4(3), E2F5(3), E2F6(1), EP300(19), ESPL1(19), GSK3B(3), HDAC1(2), HDAC2(2), HDAC3(5), HDAC4(11), HDAC5(6), HDAC6(3), HDAC8(5), MAD1L1(6), MAD2L1(1), MAD2L2(2), MCM2(11), MCM3(9), MCM4(8), MCM5(5), MCM6(5), MCM7(1), MDM2(4), MPEG1(6), MPL(9), PCNA(2), PLK1(4), PRKDC(22), PTPRA(9), PTTG1(1), RB1(10), RBL1(14), SKP2(2), SMAD4(2), TBC1D8(11), TFDP1(2), TGFB1(2), WEE1(2)	45841062	420	174	413	209	254	41	22	59	42	2	0.304	1.000	1.000
109	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	71	AKT1(4), AKT2(8), AKT3(3), BTK(15), CSF2(2), FCER1A(17), FCER1G(1), FYN(8), GAB2(4), GRB2(2), HRAS(3), IL13(2), IL3(3), IL4(1), IL5(4), INPP5D(36), KRAS(7), LAT(3), LCP2(8), LYN(11), MAP2K2(5), MAP2K3(9), MAP2K4(4), MAP2K6(3), MAP2K7(5), MAPK1(4), MAPK10(9), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MAPK3(3), MAPK8(2), MAPK9(4), MS4A2(13), PDK1(2), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(3), PIK3R2(6), PIK3R3(2), PIK3R5(17), PLA2G12B(3), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(19), PLA2G4A(16), PLA2G5(2), PLA2G6(13), PLCG1(9), PLCG2(30), PRKCA(9), PRKCD(5), PRKCE(7), RAC2(1), RAF1(11), SOS1(10), SOS2(13), SYK(15), TNF(1), VAV1(19), VAV2(5), VAV3(11)	30045277	519	174	499	243	323	41	18	61	72	4	0.0144	1.000	1.000
110	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(6), AGT(8), AGTR1(10), AGTR2(10), CMA1(6), COL4A1(66), COL4A2(36), COL4A3(50), COL4A4(122), COL4A5(68), COL4A6(43), REN(12)	10723906	437	172	404	109	339	20	8	25	40	5	0.0512	1.000	1.000
111	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	26	CPEB1(11), EGFR(25), ERBB2(10), ERBB4(59), ETS1(4), ETS2(8), ETV6(10), ETV7(7), FMN2(86), GRB2(2), KRAS(7), MAPK1(4), MAPK3(3), NOTCH1(9), NOTCH2(25), NOTCH3(27), NOTCH4(63), PIWIL1(23), PIWIL2(13), PIWIL3(16), PIWIL4(4), RAF1(11), SOS1(10), SOS2(13), SPIRE1(3), SPIRE2(7)	21390349	460	171	443	216	317	33	14	53	42	1	0.272	1.000	1.000
112	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	79	AIFM1(3), AKT1(4), AKT2(8), AKT3(3), APAF1(6), ATM(16), BAX(4), BCL2(3), BIRC2(6), BIRC3(7), CAPN1(5), CAPN2(6), CASP10(6), CASP3(2), CASP7(4), CASP8(9), CASP9(2), CFLAR(4), CHUK(2), CSF2RB(24), CYCS(1), DFFA(2), DFFB(2), FAS(5), FASLG(15), IKBKB(4), IL1A(5), IL1B(8), IL1R1(12), IL1RAP(3), IL3(3), IL3RA(8), IRAK1(5), IRAK2(15), IRAK3(11), IRAK4(3), MYD88(1), NFKB1(6), NFKB2(5), NFKBIA(2), NTRK1(16), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(3), PIK3R2(6), PIK3R3(2), PIK3R5(17), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKACA(3), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), RELA(4), RIPK1(3), TNF(1), TNFRSF10A(7), TNFRSF10B(5), TNFRSF10C(4), TNFRSF10D(9), TNFRSF1A(4), TNFSF10(9), TRAF2(2)	35079562	429	168	415	248	263	31	19	56	59	1	0.873	1.000	1.000
113	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	70	ACACB(23), ACSL1(8), ACSL3(8), ACSL4(5), ACSL5(22), ACSL6(13), ADIPOQ(5), ADIPOR1(5), ADIPOR2(1), AGRP(1), AKT1(4), AKT2(8), AKT3(3), CAMKK1(3), CAMKK2(9), CD36(6), CHUK(2), CPT1A(14), CPT1B(9), CPT1C(18), CPT2(2), G6PC(5), G6PC2(3), IKBKB(4), IRS1(5), IRS2(3), IRS4(11), JAK1(7), JAK2(8), JAK3(11), LEP(4), LEPR(31), MAPK10(9), MAPK8(2), MAPK9(4), NFKB1(6), NFKB2(5), NFKBIA(2), NFKBIB(1), NPY(4), PCK1(25), PCK2(6), POMC(4), PPARA(8), PPARGC1A(26), PRKAA1(1), PRKAA2(32), PRKAB1(2), PRKAB2(2), PRKAG1(3), PRKAG2(8), PRKAG3(11), PRKCQ(21), PTPN11(10), RELA(4), RXRA(4), RXRB(4), RXRG(6), SLC2A1(5), SLC2A4(8), SOCS3(1), STAT3(11), STK11(4), TNF(1), TNFRSF1A(4), TNFRSF1B(4), TRAF2(2), TYK2(8)	35378840	519	168	501	306	329	49	22	52	67	0	0.726	1.000	1.000
114	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CD2BP2(3), CDC40(7), CLK2(8), CLK3(2), COL2A1(44), CPSF1(8), CPSF2(2), CPSF3(3), CSTF1(6), CSTF2(4), CSTF2T(4), CSTF3(5), DDIT3(3), DDX1(4), DDX20(11), DHX15(5), DHX16(9), DHX38(10), DHX8(11), DHX9(11), DICER1(23), DNAJC8(2), FUS(1), GIPC1(6), LSM7(2), METTL3(3), NCBP1(1), NONO(10), NUDT21(3), NXF1(5), PABPN1(2), PAPOLA(4), PHF5A(2), POLR2A(13), PPM1G(2), PRPF18(4), PRPF3(6), PRPF4(3), PRPF4B(6), PRPF8(15), PSKH1(2), PTBP1(3), PTBP2(8), RBM17(1), RBM5(9), RNGTT(2), RNMT(9), RNPS1(2), SF3A1(6), SF3A2(6), SF3A3(7), SF3B1(17), SF3B2(11), SF3B4(9), SNRPA(2), SNRPA1(2), SNRPB(6), SNRPB2(2), SNRPD1(1), SNRPE(2), SNRPN(6), SNURF(3), SPOP(2), SRPK1(9), SRPK2(2), SRRM1(9), SUPT5H(7), TXNL4A(1), U2AF2(5), XRN2(6)	45295081	430	167	423	181	249	34	29	58	59	1	0.317	1.000	1.000
115	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	33	AKT1(4), AKT2(8), AKT3(3), DAG1(9), DRD2(16), EGFR(25), EPHB2(36), GRB2(2), ITPKB(11), ITPR1(36), ITPR2(20), ITPR3(12), KCNJ3(21), KCNJ5(13), KCNJ9(6), MAPK1(4), PI3(6), PIK3CB(10), PITX2(6), PLCB1(58), PLCB2(12), PLCB3(4), PLCB4(87), RAF1(11), RGS20(2), SHC1(2), SOS1(10), SOS2(13), SRC(2), STAT3(11), TERF2IP(2)	24252675	462	167	427	259	309	41	20	44	44	4	0.205	1.000	1.000
116	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	50	ACTA1(4), AGT(8), AKT1(4), CALM1(1), CALM2(1), CALR(2), CAMK1(5), CAMK1G(12), CAMK4(17), CREBBP(24), CSNK1A1(5), EDN1(9), ELSPBP1(8), F2(13), FGF2(1), GATA4(5), GSK3B(3), HAND1(2), HAND2(5), HRAS(3), IGF1(11), LIF(1), MAPK1(4), MAPK14(5), MAPK3(3), MAPK8(2), MEF2C(3), MYH2(100), NFATC1(17), NFATC2(12), NFATC3(11), NFATC4(18), NKX2-5(1), NPPA(5), PIK3CA(10), PIK3R1(3), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), RAF1(11), RPS6KB1(4), SYT1(23)	21336602	414	166	386	241	275	40	16	37	41	5	0.747	1.000	1.000
117	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(17), ADH1B(30), ADH4(12), ADH6(14), ADH7(16), ADHFE1(6), AGPAT1(1), AGPAT2(3), AGPAT3(5), AGPAT4(6), AKR1A1(4), AKR1B1(2), ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(6), ALDH3A1(10), ALDH3A2(3), ALDH9A1(3), CEL(13), DGAT1(1), DGKA(3), DGKB(29), DGKD(13), DGKE(8), DGKG(18), DGKH(12), DGKQ(7), DGKZ(9), GK(7), GLA(2), GLB1(10), LCT(54), LIPC(10), LIPF(17), LIPG(10), LPL(6), PNLIP(9), PNLIPRP1(10), PPAP2B(11), PPAP2C(8)	20528996	441	165	402	206	308	38	17	40	36	2	0.00142	1.000	1.000
118	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	81	ATF2(6), CHUK(2), DAXX(10), ELK1(3), FOS(2), GRB2(2), HRAS(3), IKBKB(4), JUN(1), MAP2K2(5), MAP2K3(9), MAP2K4(4), MAP2K5(5), MAP2K6(3), MAP2K7(5), MAP3K1(4), MAP3K10(13), MAP3K11(6), MAP3K12(3), MAP3K13(15), MAP3K2(8), MAP3K3(8), MAP3K4(19), MAP3K5(23), MAP3K6(5), MAP3K7(1), MAP3K9(27), MAP4K1(12), MAP4K2(7), MAP4K3(10), MAP4K4(12), MAP4K5(5), MAPK1(4), MAPK10(9), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MAPK3(3), MAPK4(17), MAPK6(8), MAPK7(4), MAPK8(2), MAPK9(4), MAPKAPK2(5), MAPKAPK3(5), MAPKAPK5(1), MEF2A(3), MEF2B(2), MEF2C(3), MEF2D(6), MKNK1(6), MKNK2(4), MYC(5), NFKB1(6), NFKBIA(2), PAK1(4), PAK2(9), RAF1(11), RELA(4), RIPK1(3), RPS6KA1(9), RPS6KA2(6), RPS6KA3(2), RPS6KA4(4), RPS6KA5(7), RPS6KB1(4), RPS6KB2(2), SHC1(2), SP1(5), STAT1(5), TGFB1(2), TGFB2(3), TGFB3(3), TRAF2(2)	39094051	440	164	430	233	258	48	23	59	51	1	0.669	1.000	1.000
119	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(66), COL4A2(36), COL4A3(50), COL4A4(122), COL4A5(68), COL4A6(43), P4HB(3), SLC23A1(6), SLC23A2(4), SLC2A1(5), SLC2A3(7)	10605285	410	164	379	87	318	18	10	24	36	4	0.000227	1.000	1.000
120	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(2), ACSS2(4), ACYP1(1), ADH1A(17), ADH1B(30), ADH4(12), ADH5(3), ADH6(14), ADH7(16), ADHFE1(6), AKR1A1(4), ALDH1A3(2), ALDH1B1(11), ALDH2(6), ALDH3A1(10), ALDH3A2(3), ALDH3B1(3), ALDH3B2(8), ALDH7A1(10), ALDH9A1(3), ALDOA(1), ALDOB(14), ALDOC(4), BPGM(3), DLAT(4), DLD(3), ENO1(4), ENO2(5), ENO3(4), FBP1(3), FBP2(2), G6PC(5), G6PC2(3), GALM(2), GAPDH(2), GAPDHS(3), GCK(16), GPI(3), HK1(3), HK2(15), HK3(15), LDHA(5), LDHAL6A(6), LDHAL6B(6), LDHB(2), LDHC(7), PDHA1(4), PDHA2(20), PDHB(1), PFKL(3), PFKP(2), PGAM2(3), PGAM4(1), PGK1(3), PGK2(36), PGM1(6), PGM3(1), PKLR(14), TPI1(1)	24794019	400	163	366	202	269	27	23	40	41	0	0.00919	1.000	1.000
121	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(12), ALOX12(6), ALOX12B(15), ALOX15(10), ALOX15B(9), ALOX5(14), CBR3(1), CYP2B6(21), CYP2C18(34), CYP2C19(40), CYP2C8(32), CYP2C9(41), CYP2E1(14), CYP2J2(8), CYP2U1(2), CYP4A11(29), CYP4A22(23), CYP4F2(17), CYP4F3(25), EPHX2(6), GGT1(8), GPX3(2), GPX5(19), GPX6(19), LTA4H(5), PLA2G12B(3), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(19), PLA2G4A(16), PLA2G5(2), PLA2G6(13), PTGDS(3), PTGES2(1), PTGIS(18), PTGS1(20), PTGS2(13), TBXAS1(16)	16489245	555	163	517	332	406	35	10	35	66	3	0.0303	1.000	1.000
122	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	66	AKT1(4), AKT2(8), AKT3(3), CASP9(2), CDC42(2), HRAS(3), KDR(57), KRAS(7), MAP2K2(5), MAPK1(4), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MAPK3(3), MAPKAPK2(5), MAPKAPK3(5), NFAT5(11), NFATC1(17), NFATC2(12), NFATC3(11), NFATC4(18), NOS3(20), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(3), PIK3R2(6), PIK3R3(2), PIK3R5(17), PLA2G12B(3), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(19), PLA2G4A(16), PLA2G5(2), PLA2G6(13), PLCG1(9), PLCG2(30), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKCA(9), PRKCG(16), PTGS2(13), PTK2(7), PXN(2), RAC2(1), RAF1(11), SH2D2A(5), SHC2(7), SPHK1(2), SPHK2(8), SRC(2), VEGFA(4)	30042899	502	163	483	236	323	36	14	62	64	3	0.0183	1.000	1.000
123	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(4), AKT1(4), BDKRB2(10), CALM1(1), CALM2(1), CAV1(1), CHRM1(5), CHRNA1(7), FLT1(42), FLT4(31), KDR(57), NOS3(20), PDE2A(16), PDE3A(30), PDE3B(6), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKG1(14), PRKG2(16), RYR2(99), SLC7A1(6), SYT1(23)	17323211	420	163	396	237	283	36	10	40	49	2	0.229	1.000	1.000
124	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(4), ACP2(3), ACP5(3), ACPP(9), ACPT(3), ALPI(9), ALPL(11), ALPP(9), ALPPL2(12), CYP19A1(15), CYP1A1(10), CYP1A2(9), CYP2A13(13), CYP2A6(11), CYP2A7(9), CYP2B6(21), CYP2C18(34), CYP2C19(40), CYP2C8(32), CYP2C9(41), CYP2D6(3), CYP2E1(14), CYP2F1(13), CYP2J2(8), CYP3A4(21), CYP3A5(14), CYP3A7(18), CYP4B1(27), CYP51A1(1), PON1(14)	12424580	431	162	401	253	324	22	11	20	52	2	0.00946	1.000	1.000
125	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	61	AKT1(4), AKT2(8), AKT3(3), CDC42(2), CDK2(1), CDKN1B(1), CREB5(9), ERBB4(59), F2RL2(8), GAB1(8), GRB2(2), GSK3A(1), GSK3B(3), IFI27(2), IGF1(11), IGFBP1(3), INPPL1(16), IRS1(5), IRS2(3), IRS4(11), MET(23), MYC(5), NOLC1(7), PAK1(4), PAK2(9), PAK3(10), PAK4(8), PAK6(6), PAK7(55), PARD3(20), PARD6A(1), PDK1(2), PIK3CA(10), PIK3CD(8), PPP1R13B(9), PREX1(10), PTK2(7), PTPN1(4), RPS6KA1(9), RPS6KA2(6), RPS6KA3(2), RPS6KB1(4), SFN(2), SHC1(2), SLC2A4(8), SOS1(10), SOS2(13), TSC1(9), TSC2(14), YWHAB(1), YWHAE(2), YWHAG(2), YWHAQ(3)	32347743	445	161	426	241	270	44	21	57	52	1	0.663	1.000	1.000
126	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP2(7), BMP4(5), BMP5(33), BMP6(12), BMP7(5), BMP8A(2), BMP8B(1), BTRC(4), CSNK1A1(5), CSNK1A1L(7), CSNK1D(3), CSNK1E(5), CSNK1G1(5), CSNK1G2(3), CSNK1G3(3), DHH(2), FBXW11(6), GLI1(17), GLI2(44), GLI3(19), GSK3B(3), HHIP(26), IHH(4), LRP2(108), PRKACA(3), PRKACB(4), PRKACG(10), PRKX(3), PTCH1(6), PTCH2(18), RAB23(1), SHH(3), SMO(10), STK36(17), SUFU(2), WNT1(2), WNT10A(7), WNT10B(6), WNT11(4), WNT16(4), WNT2(8), WNT2B(5), WNT3(5), WNT3A(8), WNT4(1), WNT5A(5), WNT5B(5), WNT6(3), WNT7A(13), WNT7B(6), WNT8A(6), WNT8B(8), WNT9A(4), WNT9B(6), ZIC2(3)	25738464	515	160	479	257	351	47	19	49	49	0	0.0260	1.000	1.000
127	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG1(7), ACTG2(6), ACTR2(3), ACTR3(2), AKT1(4), ANGPTL2(3), CDC42(2), CFL1(2), FLNA(23), FLNC(69), FSCN1(4), FSCN2(2), FSCN3(13), GDI1(2), GDI2(3), LIMK1(5), MYH2(100), MYLK(48), MYLK2(13), PAK1(4), PAK2(9), PAK3(10), PAK4(8), PAK6(6), PAK7(55), RHO(2), ROCK1(6), ROCK2(14), VASP(3), WASF1(5), WASL(4)	20341404	437	160	401	236	302	46	12	39	36	2	0.0256	1.000	1.000
128	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	62	ATM(16), CCNA1(16), CCND1(2), CCND2(7), CCND3(2), CCNE1(4), CCNE2(6), CCNG2(1), CCNH(1), CDC25A(8), CDK2(1), CDK7(2), CDKN1A(3), CDKN1B(1), CDKN2C(1), CREB3L1(7), CREB3L3(10), CREB3L4(7), E2F1(6), E2F2(5), E2F3(4), E2F4(3), E2F5(3), E2F6(1), GBA2(2), MCM2(11), MCM3(9), MCM4(8), MCM5(5), MCM6(5), MCM7(1), MDM2(4), MNAT1(2), MYC(5), MYT1(21), NACA(44), PCNA(2), POLA2(9), POLE(16), POLE2(2), PRIM1(3), RB1(10), RBL1(14), RPA1(3), RPA2(2), TFDP1(2), TFDP2(3), TNXB(126), WEE1(2)	32651895	428	158	419	199	287	36	17	51	35	2	0.0544	1.000	1.000
129	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	AKT1(4), AKT2(8), AKT3(3), BCL2(3), BCR(14), BLNK(15), BTK(15), CD19(8), CD22(26), CD81(3), CR2(35), CSK(1), DAG1(9), FLOT1(1), GRB2(2), GSK3A(1), GSK3B(3), INPP5D(36), ITPR1(36), ITPR2(20), ITPR3(12), LYN(11), MAP4K1(12), MAPK1(4), MAPK3(3), NFATC1(17), NFATC2(12), NR0B2(6), PDK1(2), PIK3CA(10), PIK3CD(8), PIK3R1(3), PLCG2(30), PPP1R13B(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PTPRC(36), RAF1(11), SHC1(2), SOS1(10), SOS2(13), SYK(15), VAV1(19)	31460302	499	158	475	250	319	37	26	52	60	5	0.0543	1.000	1.000
130	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(37), ASH2L(5), CARM1(7), CTCFL(21), DOT1L(12), EED(3), EHMT1(11), EHMT2(9), EZH1(10), EZH2(13), FBXO11(7), HCFC1(21), HSF4(1), JMJD4(7), JMJD6(2), KDM6A(3), MEN1(3), NSD1(21), OGT(9), PAXIP1(3), PPP1CA(3), PPP1CB(5), PPP1CC(2), PRDM2(15), PRDM7(5), PRDM9(51), PRMT5(7), PRMT7(4), PRMT8(10), RBBP5(4), SATB1(22), SETD1A(27), SETD2(16), SETD7(2), SETD8(1), SETDB1(10), SETDB2(4), SETMAR(8), SMYD3(2), STK38(5), SUV39H1(1), SUV39H2(2), SUV420H1(8), SUV420H2(2), SUZ12(3), WHSC1(10), WHSC1L1(6)	50390913	440	157	427	195	278	50	13	60	39	0	0.415	1.000	1.000
131	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(6), ACAA2(1), ACADL(5), ACADM(5), ACADS(5), ACADSB(6), ACADVL(1), ACAT2(1), ACOX1(8), ACOX3(13), ACSL1(8), ACSL3(8), ACSL4(5), ACSL5(22), ACSL6(13), ADH1A(17), ADH1B(30), ADH4(12), ADH5(3), ADH6(14), ADH7(16), ADHFE1(6), ALDH1A3(2), ALDH1B1(11), ALDH2(6), ALDH3A1(10), ALDH3A2(3), ALDH7A1(10), ALDH9A1(3), CPT1A(14), CPT1B(9), CPT1C(18), CPT2(2), CYP4A11(29), CYP4A22(23), ECHS1(3), EHHADH(6), GCDH(6), HADH(3), HADHA(6), HADHB(6), HSD17B10(2), HSD17B4(6)	20936387	383	157	352	174	271	26	22	24	39	1	0.00525	1.000	1.000
132	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	40	ALAD(5), ALAS1(2), ALAS2(6), BLVRA(2), BLVRB(1), COX10(7), COX15(4), CP(14), CPOX(4), EARS2(2), EPRS(13), FECH(3), FTH1(3), FTMT(6), GUSB(5), HCCS(2), HMBS(1), HMOX1(1), HMOX2(1), MMAB(2), PPOX(3), UGT1A1(12), UGT1A10(18), UGT1A3(14), UGT1A4(10), UGT1A5(10), UGT1A6(15), UGT1A7(12), UGT1A9(16), UGT2A1(25), UGT2A3(32), UGT2B11(23), UGT2B15(31), UGT2B17(30), UGT2B28(29), UGT2B4(35), UGT2B7(19), UROS(1)	17058931	419	157	375	158	288	33	18	24	54	2	1.08e-05	1.000	1.000
133	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	43	ACTR2(3), ACTR3(2), AKT1(4), AKT2(8), AKT3(3), ANGPTL2(3), ARHGAP1(3), ARHGAP4(4), ARHGEF11(22), BTK(15), CDC42(2), CFL1(2), GDI1(2), GDI2(3), INPPL1(16), ITPR1(36), ITPR2(20), ITPR3(12), LIMK1(5), MYLK(48), MYLK2(13), PAK1(4), PAK2(9), PAK3(10), PAK4(8), PAK6(6), PAK7(55), PDK1(2), PIK3CA(10), PIK3CD(8), PIK3CG(28), PIK3R1(3), PITX2(6), PPP1R13B(9), RACGAP1(4), RHO(2), ROCK1(6), ROCK2(14), SAG(11), WASF1(5), WASL(4)	29440830	430	157	406	214	285	35	17	54	38	1	0.0403	1.000	1.000
134	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(15), ACTB(9), ACTG1(7), ARHGEF2(21), ARPC5(1), CD14(6), CDC42(2), CDH1(6), CLDN1(5), CTNNB1(17), CTTN(4), EZR(7), FYN(8), HCLS1(15), ITGB1(4), KRT18(4), LY96(4), NCK1(2), NCK2(4), NCL(6), OCLN(6), PRKCA(9), RHOA(2), ROCK1(6), ROCK2(14), TLR4(42), TLR5(22), TUBA1A(4), TUBA1B(4), TUBA1C(2), TUBA3C(24), TUBA3D(13), TUBA3E(4), TUBA4A(7), TUBA8(5), TUBAL3(13), TUBB(1), TUBB1(5), TUBB2A(2), TUBB3(4), TUBB6(10), TUBB8(11), WAS(8), WASL(4), YWHAQ(3)	22350623	372	156	353	171	232	36	14	47	42	1	0.00905	1.000	1.000
135	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(15), ACTB(9), ACTG1(7), ARHGEF2(21), ARPC5(1), CD14(6), CDC42(2), CDH1(6), CLDN1(5), CTNNB1(17), CTTN(4), EZR(7), FYN(8), HCLS1(15), ITGB1(4), KRT18(4), LY96(4), NCK1(2), NCK2(4), NCL(6), OCLN(6), PRKCA(9), RHOA(2), ROCK1(6), ROCK2(14), TLR4(42), TLR5(22), TUBA1A(4), TUBA1B(4), TUBA1C(2), TUBA3C(24), TUBA3D(13), TUBA3E(4), TUBA4A(7), TUBA8(5), TUBAL3(13), TUBB(1), TUBB1(5), TUBB2A(2), TUBB3(4), TUBB6(10), TUBB8(11), WAS(8), WASL(4), YWHAQ(3)	22350623	372	156	353	171	232	36	14	47	42	1	0.00905	1.000	1.000
136	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ADH1A(17), ADH1B(30), ADH4(12), ADH5(3), ADH6(14), ADH7(16), ADHFE1(6), ALDH1A3(2), ALDH3A1(10), ALDH3B1(3), ALDH3B2(8), AOC2(9), AOC3(9), AOX1(29), CARM1(7), COMT(4), DBH(16), DCT(4), DDC(16), ECH1(5), ESCO1(2), ESCO2(4), FAH(4), GOT1(6), GOT2(6), GSTZ1(1), HEMK1(4), HGD(15), HPD(7), LCMT1(4), LCMT2(1), MAOA(4), MAOB(13), METTL2B(5), METTL6(2), NAT6(5), PNMT(4), PNPLA3(3), PRMT2(2), PRMT3(5), PRMT5(7), PRMT7(4), PRMT8(10), SH3GLB1(2), TAT(21), TH(11), TPO(47), TYR(11), TYRP1(9), WBSCR22(2)	25297475	441	155	414	238	304	36	22	36	43	0	0.230	1.000	1.000
137	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	22	ADRB1(5), AKT1(4), APC(27), CAMP(2), CAV3(2), DAG1(9), DLG4(6), EPHB2(36), GNAI1(2), GNAQ(6), ITPR1(36), ITPR2(20), ITPR3(12), KCNJ3(21), KCNJ5(13), KCNJ9(6), MAPK1(4), PITX2(6), PTX3(1), RHO(2), RYR1(114)	19228527	334	155	322	211	222	31	16	27	36	2	0.429	1.000	1.000
138	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	AICDA(9), CAD(18), CANT1(11), CDA(3), CTPS2(5), DCTD(3), DHODH(5), DPYD(73), DPYS(28), ENTPD1(12), ENTPD3(9), ENTPD4(3), ENTPD5(3), ENTPD6(4), ENTPD8(2), ITPA(1), NME1(1), NME4(1), NME6(3), NME7(5), NT5C1A(6), NT5C1B(24), NT5C2(3), NT5E(6), NT5M(2), NUDT2(2), PNPT1(2), POLA1(3), POLA2(9), POLD1(7), POLD2(2), POLD3(7), POLE(16), POLE2(2), POLR1A(13), POLR1B(8), POLR1C(1), POLR2A(13), POLR2B(14), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(2), POLR2H(2), POLR2J(2), POLR2L(1), POLR3A(8), POLR3B(15), POLR3G(1), POLR3GL(3), POLR3H(1), POLR3K(1), PRIM1(3), PRIM2(6), RRM1(3), RRM2(4), RRM2B(2), TK2(1), TXNRD1(5), TXNRD2(3), TYMS(2), UCK1(3), UCK2(1), UMPS(2), UPB1(11), UPP1(1), UPP2(6), UPRT(1)	34487643	432	154	405	225	279	34	15	61	42	1	0.257	1.000	1.000
139	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	ADAM17(1), APH1A(3), CREBBP(24), CTBP2(1), DLL1(3), DLL3(7), DLL4(12), DTX1(7), DTX2(2), DTX3(4), DTX3L(6), DTX4(4), DVL1(1), DVL2(3), DVL3(9), EP300(19), HDAC1(2), HDAC2(2), HES1(2), JAG1(10), JAG2(10), LFNG(5), MAML1(9), MAML2(7), MAML3(9), MFNG(8), NCOR2(28), NCSTN(5), NOTCH1(9), NOTCH2(25), NOTCH3(27), NOTCH4(63), NUMB(4), NUMBL(4), PSEN1(3), PSEN2(2), PSENEN(1), PTCRA(3), RBPJ(6), RBPJL(4), SNW1(3)	29318409	357	153	353	206	216	39	13	49	40	0	0.903	1.000	1.000
140	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(8), F11(14), F12(1), F13B(35), F2(13), F5(39), F7(7), F8(49), F9(15), FGA(41), FGB(10), FGG(10), LPA(59), PLAT(5), PLG(36), SERPINB2(20), SERPINE1(6), SERPINF2(7), VWF(59)	14972071	434	152	412	173	307	26	23	38	38	2	0.00560	1.000	1.000
141	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	31	AKT1(4), AKT2(8), AKT3(3), BCR(14), BTK(15), CD19(8), DAPP1(6), FLOT1(1), GAB1(8), ITPR1(36), ITPR2(20), ITPR3(12), LYN(11), NR0B2(6), PDK1(2), PHF11(1), PIK3CA(10), PITX2(6), PLCG2(30), PPP1R13B(9), PREX1(10), PTPRC(36), RPS6KA1(9), RPS6KA2(6), RPS6KA3(2), RPS6KB1(4), SAG(11), SYK(15), TEC(13), VAV1(19)	22834294	335	152	314	192	215	25	18	37	38	2	0.314	1.000	1.000
142	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(10), CD28(2), CD3D(7), CSK(1), CTLA4(2), DAG1(9), EPHB2(36), FBXW7(11), GRAP2(6), GRB2(2), ITK(25), ITPKB(11), LAT(3), LCK(15), LCP2(8), MAPK1(4), NCK1(2), NFAT5(11), NFKB1(6), NFKB2(5), NFKBIA(2), NFKBIB(1), NFKBIL1(2), PAK1(4), PAK2(9), PAK3(10), PAK4(8), PAK6(6), PAK7(55), PLCG1(9), PTPRC(36), RAF1(11), RASGRP1(11), RASGRP2(8), RASGRP3(12), RASGRP4(12), SOS1(10), SOS2(13), VAV1(19), ZAP70(8)	23625534	422	152	402	213	266	33	17	48	55	3	0.264	1.000	1.000
143	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	24	AKR1B1(2), GUSB(5), UGDH(1), UGP2(1), UGT1A1(12), UGT1A10(18), UGT1A3(14), UGT1A4(10), UGT1A5(10), UGT1A6(15), UGT1A7(12), UGT1A9(16), UGT2A1(25), UGT2A3(32), UGT2B11(23), UGT2B15(31), UGT2B17(30), UGT2B28(29), UGT2B4(35), UGT2B7(19), XYLB(6)	10705114	346	150	303	136	244	26	14	18	43	1	0.000191	1.000	1.000
144	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AADAT(5), AANAT(1), ACAT2(1), ACMSD(13), AFMID(1), ALDH1A3(2), ALDH1B1(11), ALDH2(6), ALDH3A1(10), ALDH3A2(3), ALDH7A1(10), ALDH9A1(3), AOC2(9), AOC3(9), AOX1(29), ASMT(8), CARM1(7), CAT(8), CYP1A1(10), CYP1A2(9), CYP1B1(4), DDC(16), ECHS1(3), EHHADH(6), GCDH(6), HAAO(3), HADH(3), HADHA(6), HEMK1(4), HSD17B10(2), HSD17B4(6), INMT(13), KMO(7), KYNU(16), LCMT1(4), LCMT2(1), LNX1(19), MAOA(4), MAOB(13), METTL2B(5), METTL6(2), NFX1(10), OGDH(9), OGDHL(44), PRMT2(2), PRMT3(5), PRMT5(7), PRMT7(4), PRMT8(10), TDO2(4), TPH1(12), TPH2(13), WARS(5), WARS2(4), WBSCR22(2)	25767980	429	148	408	221	287	35	19	46	40	2	0.0953	1.000	1.000
145	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	60	APAF1(6), ATM(16), ATR(22), BAI1(16), BAX(4), CASP3(2), CASP8(9), CASP9(2), CCNB2(2), CCNB3(31), CCND1(2), CCND2(7), CCND3(2), CCNE1(4), CCNE2(6), CCNG1(2), CCNG2(1), CDK2(1), CDK6(2), CDKN1A(3), CHEK1(2), CHEK2(2), CYCS(1), DDB2(3), EI24(3), FAS(5), GADD45B(2), GTSE1(8), IGF1(11), IGFBP3(3), MDM2(4), MDM4(2), PERP(3), PPM1D(4), RFWD2(7), RPRM(3), RRM2(4), RRM2B(2), SERPINB5(8), SERPINE1(6), SESN1(1), SESN2(7), SESN3(1), SFN(2), STEAP3(9), THBS1(31), TNFRSF10B(5), TP53I3(2), TP73(6), TSC2(14), ZMAT3(1)	26436248	302	148	295	169	194	24	16	34	33	1	0.735	1.000	1.000
146	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	IMPA1(1), INPP1(3), INPP4A(7), INPP4B(4), INPP5A(5), INPPL1(16), ITPKB(11), MIOX(5), OCRL(7), PIK3C2A(8), PIK3C2B(16), PIK3C2G(56), PIK3CA(10), PIK3CB(10), PIK3CG(28), PLCB1(58), PLCB2(12), PLCB3(4), PLCB4(87), PLCD1(3), PLCG1(9), PLCG2(30)	18985076	390	148	352	175	272	20	16	34	45	3	0.00373	1.000	1.000
147	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	64	ADAM10(9), ADAM17(1), ATP6AP1(3), ATP6V0A1(13), ATP6V0A2(5), ATP6V0A4(23), ATP6V0C(1), ATP6V0D1(1), ATP6V0D2(9), ATP6V0E1(1), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1E2(3), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(7), ATP6V1H(5), CASP3(2), CDC42(2), CHUK(2), CSK(1), EGFR(25), F11R(7), GIT1(6), HBEGF(1), IGSF5(12), IKBKB(4), JAM2(11), JAM3(3), JUN(1), LYN(11), MAP2K4(4), MAPK10(9), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MAPK8(2), MAPK9(4), MET(23), NFKB1(6), NFKB2(5), NFKBIA(2), NOD1(9), PAK1(4), PLCG1(9), PLCG2(30), PTPN11(10), PTPRZ1(27), RELA(4), SRC(2), TCIRG1(6), TJP1(16)	29808581	373	147	366	223	223	31	17	52	49	1	0.884	1.000	1.000
148	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ADH1A(17), ADH1B(30), ADH4(12), ADH6(14), ADH7(16), ADHFE1(6), AKR1A1(4), ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(6), ALDH3A1(10), ALDH3A2(3), ALDH3B1(3), ALDH3B2(8), ALDH9A1(3), ALDOA(1), ALDOB(14), ALDOC(4), BPGM(3), DLAT(4), DLD(3), ENO1(4), ENO2(5), ENO3(4), FBP1(3), FBP2(2), G6PC(5), GAPDH(2), GCK(16), GPI(3), HK1(3), HK2(15), HK3(15), LDHA(5), LDHB(2), LDHC(7), PDHA1(4), PDHA2(20), PDHB(1), PFKP(2), PGK1(3), PGM1(6), PGM3(1), PKLR(14), TPI1(1)	20812840	341	146	311	163	231	26	18	35	31	0	0.00296	1.000	1.000
149	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ADH1A(17), ADH1B(30), ADH4(12), ADH6(14), ADH7(16), ADHFE1(6), AKR1A1(4), ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(6), ALDH3A1(10), ALDH3A2(3), ALDH3B1(3), ALDH3B2(8), ALDH9A1(3), ALDOA(1), ALDOB(14), ALDOC(4), BPGM(3), DLAT(4), DLD(3), ENO1(4), ENO2(5), ENO3(4), FBP1(3), FBP2(2), G6PC(5), GAPDH(2), GCK(16), GPI(3), HK1(3), HK2(15), HK3(15), LDHA(5), LDHB(2), LDHC(7), PDHA1(4), PDHA2(20), PDHB(1), PFKP(2), PGK1(3), PGM1(6), PGM3(1), PKLR(14), TPI1(1)	20812840	341	146	311	163	231	26	18	35	31	0	0.00296	1.000	1.000
150	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	63	ACHE(9), AGPAT1(1), AGPAT2(3), AGPAT3(5), AGPAT4(6), AGPAT6(3), CDS1(11), CDS2(5), CHAT(20), CHKA(2), CHKB(3), CHPT1(1), CRLS1(1), DGKA(3), DGKB(29), DGKD(13), DGKE(8), DGKG(18), DGKH(12), DGKI(36), DGKQ(7), DGKZ(9), ESCO1(2), ESCO2(4), ETNK1(5), GNPAT(1), GPAM(6), GPD1(10), GPD1L(2), GPD2(3), LYPLA1(1), LYPLA2(1), NAT6(5), PCYT1A(3), PCYT1B(9), PEMT(2), PISD(2), PLA2G12B(3), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(19), PLA2G4A(16), PLA2G5(2), PLA2G6(13), PLD1(14), PLD2(8), PNPLA3(3), PPAP2B(11), PPAP2C(8), PTDSS2(3), SH3GLB1(2)	27808795	382	146	360	202	244	32	17	40	46	3	0.267	1.000	1.000
151	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	B2M(5), CALR(2), CANX(1), CD4(9), CD74(8), CD8A(2), CD8B(9), CIITA(18), CTSS(7), HLA-A(4), HLA-B(6), HLA-C(2), HLA-DMA(7), HLA-DMB(7), HLA-DOA(6), HLA-DOB(9), HLA-DPA1(2), HLA-DPB1(2), HLA-DQA1(7), HLA-DQA2(8), HLA-DQB1(4), HLA-DRA(13), HLA-DRB1(5), HLA-DRB5(1), HLA-E(1), HLA-F(2), HLA-G(5), HSP90AA1(2), HSP90AB1(8), HSPA5(7), IFI30(1), IFNA1(1), IFNA10(2), IFNA13(1), IFNA14(8), IFNA16(11), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA5(4), IFNA6(3), IFNA7(6), IFNA8(3), KIR2DL3(5), KIR3DL1(14), KIR3DL2(16), KIR3DL3(5), KLRC1(4), KLRC2(1), KLRC3(12), KLRC4(6), KLRD1(7), LGMN(5), LTA(5), NFYA(1), NFYB(2), NFYC(2), PDIA3(3), PSME2(4), RFX5(5), RFXANK(1), RFXAP(1), TAP1(2), TAP2(7), TAPBP(1)	19638215	329	146	314	203	217	30	14	35	32	1	0.617	1.000	1.000
152	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM1(1), CALM2(1), DLG4(6), GRIN1(8), GRIN2A(107), GRIN2B(59), GRIN2C(10), GRIN2D(11), NOS1(77), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCA(9), SYT1(23)	10852964	350	146	327	218	255	29	8	23	33	2	0.265	1.000	1.000
153	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	58	ALG2(5), BAK1(2), BAX(4), BFAR(1), BTK(15), CAD(18), CASP10(6), CASP3(2), CASP8(9), CD7(2), CDK2AP1(2), CSNK1A1(5), DAXX(10), DEDD(2), DEDD2(3), DFFA(2), DIABLO(2), EGFR(25), EPHB2(36), FAF1(9), FAIM2(6), HSPB1(2), IL1A(5), MAP2K4(4), MAP2K7(5), MAP3K1(4), MAP3K5(23), MAPK1(4), MAPK10(9), MAPK8(2), MAPK8IP1(7), MAPK8IP2(8), MAPK8IP3(9), MAPK9(4), MET(23), NFAT5(11), NFKB1(6), NFKB2(5), NFKBIA(2), NFKBIB(1), NFKBIL1(2), NR0B2(6), PTPN13(17), RALBP1(3), RIPK1(3), ROCK1(6), SMPD1(2), TNFRSF6B(4), TPX2(11), TRAF2(2), TUFM(1)	30548804	357	146	345	217	216	24	18	48	50	1	0.968	1.000	1.000
154	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	57	APC(27), AXIN1(10), CCND1(2), CCND2(7), CCND3(2), CSNK1E(5), CTNNB1(17), DVL1(1), DVL2(3), DVL3(9), FBXW2(2), FZD1(5), FZD10(4), FZD2(7), FZD3(1), FZD5(2), FZD6(2), FZD7(5), FZD8(6), FZD9(1), GSK3B(3), JUN(1), LDLR(17), MAPK10(9), MAPK9(4), MYC(5), PAFAH1B1(6), PPP2R5C(4), PPP2R5E(5), PRKCA(9), PRKCD(5), PRKCE(7), PRKCG(16), PRKCH(9), PRKCI(8), PRKCQ(21), PRKCZ(3), PRKD1(9), RHOA(2), SFRP4(6), TCF7(1), WNT1(2), WNT10A(7), WNT10B(6), WNT11(4), WNT16(4), WNT2(8), WNT2B(5), WNT3(5), WNT4(1), WNT5A(5), WNT5B(5), WNT6(3), WNT7A(13), WNT7B(6)	25283138	342	145	332	200	209	33	10	39	51	0	0.609	1.000	1.000
155	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	AGMAT(4), ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(6), ALDH3A1(10), ALDH3A2(3), ALDH4A1(6), ALDH9A1(3), AOC2(9), AOC3(9), ARG1(2), ARG2(2), ASL(7), CKM(3), CKMT1A(1), CKMT2(5), CPS1(29), DAO(12), GAMT(4), GATM(6), GLUD1(2), GOT1(6), GOT2(6), MAOA(4), MAOB(13), NOS1(77), NOS3(20), OAT(4), ODC1(3), OTC(4), P4HA1(10), P4HA2(5), P4HA3(14), P4HB(3), PYCR1(1), RARS(7), SMS(5)	18768312	341	144	323	187	215	35	17	30	43	1	0.183	1.000	1.000
156	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(9), AGPAT1(1), AGPAT2(3), AGPAT3(5), AGPAT4(6), AGPS(5), CDS1(11), CDS2(5), CHAT(20), CHKA(2), CHKB(3), CLC(5), CPT1B(9), DGKA(3), DGKB(29), DGKD(13), DGKE(8), DGKG(18), DGKH(12), DGKQ(7), DGKZ(9), ETNK1(5), GNPAT(1), GPD1(10), GPD2(3), LGALS13(4), LYPLA1(1), LYPLA2(1), PAFAH1B1(6), PAFAH2(2), PCYT1A(3), PCYT1B(9), PEMT(2), PISD(2), PLA2G1B(1), PLA2G2A(2), PLA2G2E(5), PLA2G3(19), PLA2G4A(16), PLA2G5(2), PLA2G6(13), PLCB2(12), PLCG1(9), PLCG2(30), PPAP2B(11), PPAP2C(8)	21257308	360	143	344	184	236	28	12	36	44	4	0.0288	1.000	1.000
157	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(55), C5(23), C6(72), C7(49), ICAM1(2), IL1A(5), IL6(2), ITGA4(45), ITGAL(27), ITGB1(4), ITGB2(17), SELP(38), SELPLG(11), TNF(1), VCAM1(17)	10497617	368	143	333	152	262	11	17	35	38	5	0.000427	1.000	1.000
158	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ADH1A(17), ADH1B(30), ADH4(12), ADH6(14), ADH7(16), ADHFE1(6), ALDH1A3(2), ALDH3A1(10), ALDH3B1(3), ALDH3B2(8), AOC2(9), AOC3(9), AOX1(29), COMT(4), DBH(16), DCT(4), DDC(16), FAH(4), GOT1(6), GOT2(6), GSTZ1(1), HGD(15), HPD(7), MAOA(4), MAOB(13), PNMT(4), TAT(21), TH(11), TPO(47), TYR(11)	13462769	355	143	330	194	256	28	15	22	34	0	0.0534	1.000	1.000
159	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(10), AKR1D1(21), ARSB(3), ARSD(3), ARSE(5), CYP11B1(17), CYP11B2(12), HSD11B1(14), HSD11B2(2), HSD17B2(13), HSD17B3(5), HSD3B1(15), HSD3B2(14), SRD5A1(2), STS(7), SULT1E1(16), SULT2A1(9), UGT1A1(12), UGT1A10(18), UGT1A3(14), UGT1A4(10), UGT1A5(10), UGT1A6(15), UGT1A7(12), UGT1A9(16), UGT2B15(31), UGT2B4(35)	11606136	341	141	307	147	228	36	15	22	38	2	0.000143	1.000	1.000
160	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(2), AKR1B10(10), B4GALT1(2), B4GALT2(2), G6PC(5), G6PC2(3), GAA(8), GALK1(2), GALK2(2), GALT(2), GANC(6), GCK(16), GLA(2), GLB1(10), HK1(3), HK2(15), HK3(15), HSD3B7(5), LALBA(8), LCT(54), MGAM(169), PFKL(3), PFKP(2), PGM1(6), PGM3(1), RDH11(2), RDH12(2), RDH13(3), RDH14(1), UGP2(1)	16418433	362	141	339	214	268	29	6	33	25	1	0.194	1.000	1.000
161	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(10), ALOX15(10), ALOX5(14), CYP1A2(9), CYP2C18(34), CYP2C19(40), CYP2C8(32), CYP2C9(41), CYP2E1(14), CYP2J2(8), CYP3A4(21), CYP3A43(19), CYP3A5(14), CYP3A7(18), HSD3B7(5), PLA2G12B(3), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(19), PLA2G4A(16), PLA2G5(2), PLA2G6(13), RDH11(2), RDH12(2), RDH13(3), RDH14(1)	10175182	369	141	345	206	271	19	11	19	46	3	0.0290	1.000	1.000
162	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	CAD(18), CANT1(11), CDA(3), CTPS2(5), DCTD(3), DHODH(5), DPYD(73), DPYS(28), ENTPD1(12), ITPA(1), NME1(1), NT5E(6), NT5M(2), NUDT2(2), POLB(1), POLD1(7), POLD2(2), POLE(16), POLG(8), POLL(10), POLQ(26), POLR1B(8), POLR2A(13), POLR2B(14), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(2), POLR2H(2), POLR2J(2), POLR2L(1), POLRMT(4), RRM1(3), RRM2(4), TK2(1), TXNRD1(5), TYMS(2), UCK1(3), UCK2(1), UMPS(2), UNG(5), UPB1(11), UPP1(1)	24451868	327	141	302	152	207	29	11	48	31	1	0.0374	1.000	1.000
163	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	35	CALM1(1), CALM2(1), CAMK1(5), CAMK1G(12), ELK1(3), FPR1(22), GNA15(7), GNB1(1), HRAS(3), MAP2K2(5), MAP2K3(9), MAP2K6(3), MAP3K1(4), MAPK1(4), MAPK14(5), MAPK3(3), NCF1(3), NCF2(8), NFATC1(17), NFATC2(12), NFATC3(11), NFATC4(18), NFKB1(6), NFKBIA(2), PAK1(4), PIK3C2G(56), PLCB1(58), PPP3CA(5), PPP3CB(4), PPP3CC(2), RAF1(11), RELA(4), SYT1(23)	15711661	332	140	303	143	226	26	12	29	38	1	0.0183	1.000	1.000
164	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(56), B3GALT4(2), CDR1(13), DGKI(36), IL6ST(11), MRPL19(1), PIGK(7), RPL10(4), RPL11(4), RPL12(1), RPL13(1), RPL13A(2), RPL14(1), RPL15(2), RPL17(2), RPL18(3), RPL18A(2), RPL19(1), RPL21(2), RPL22(2), RPL26(1), RPL27(3), RPL27A(1), RPL29(1), RPL3(2), RPL30(1), RPL32(1), RPL35(1), RPL35A(1), RPL38(1), RPL39(1), RPL3L(5), RPL4(4), RPL5(8), RPL6(1), RPL7(2), RPLP0(1), RPLP2(1), RPS11(1), RPS13(1), RPS15(1), RPS16(1), RPS18(2), RPS19(1), RPS2(2), RPS20(2), RPS23(1), RPS24(1), RPS26(1), RPS27(2), RPS29(1), RPS3A(1), RPS5(1), RPS6(1), RPS6KA1(9), RPS6KA2(6), RPS6KA3(2), RPS6KA6(21), RPS6KB1(4), RPS6KB2(2), RPS7(4), RPS8(1), RPSA(1), SLC36A2(12), TBC1D10C(6), TSPAN9(4), UBB(1), UBC(6)	22127343	288	140	273	168	180	26	14	33	35	0	0.689	1.000	1.000
165	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	38	AKT1(4), AKT2(8), AKT3(3), BCR(14), BLNK(15), BTK(15), CD19(8), CSK(1), DAG1(9), EPHB2(36), GRB2(2), ITPKB(11), LYN(11), MAP2K2(5), MAPK1(4), NFAT5(11), NFKB1(6), NFKB2(5), NFKBIA(2), NFKBIB(1), NFKBIL1(2), PI3(6), PIK3CA(10), PIK3CD(8), PIK3R1(3), PLCG2(30), PPP1R13B(9), RAF1(11), SERPINA4(22), SHC1(2), SOS1(10), SOS2(13), SYK(15), VAV1(19)	22173972	331	140	319	190	202	27	14	43	42	3	0.747	1.000	1.000
166	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(2), B4GALT1(2), B4GALT2(2), FBP2(2), G6PC(5), GAA(8), GALK1(2), GALK2(2), GALT(2), GANAB(6), GCK(16), GLA(2), GLB1(10), HK1(3), HK2(15), HK3(15), LALBA(8), LCT(54), MGAM(169), PFKP(2), PGM1(6), PGM3(1)	13840899	334	139	311	193	248	29	5	29	22	1	0.149	1.000	1.000
167	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	24	ATM(16), BMPR1B(4), CCND2(7), CDKN1B(1), DAZL(5), DMC1(11), EGR1(4), ESR2(10), FSHR(21), GJA4(4), INHA(4), LHCGR(29), MLH1(7), MSH5(13), NCOR1(23), NR5A1(10), NRIP1(10), PGR(16), PRLR(37), PTGER2(7), SMPD1(2), VDR(3), ZP2(17)	14596097	261	138	238	137	172	18	8	29	33	1	0.641	1.000	1.000
168	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	37	AKT1(4), ATF2(6), CDC42(2), DLD(3), DUSP10(9), DUSP4(3), DUSP8(3), GAB1(8), GCK(16), IL1R1(12), JUN(1), MAP2K4(4), MAP2K5(5), MAP2K7(5), MAP3K1(4), MAP3K10(13), MAP3K11(6), MAP3K12(3), MAP3K13(15), MAP3K2(8), MAP3K3(8), MAP3K4(19), MAP3K5(23), MAP3K7(1), MAP3K9(27), MAPK10(9), MAPK7(4), MAPK8(2), MAPK9(4), MYEF2(4), NFATC3(11), NR2C2(1), PAPPA(59), SHC1(2), TRAF6(4), ZAK(7)	21081080	315	138	302	160	211	26	8	35	33	2	0.711	1.000	1.000
169	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(11), ACADL(5), ACADM(5), ACADSB(6), ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(6), ALDH3A1(10), ALDH3A2(3), ALDH9A1(3), AOC2(9), AOC3(9), CNDP1(10), DPYD(73), DPYS(28), ECHS1(3), EHHADH(6), GAD1(14), GAD2(9), HADHA(6), MLYCD(2), SDS(3), SMS(5), UPB1(11)	12394672	273	137	248	118	176	22	10	36	29	0	0.00993	1.000	1.000
170	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	50	ACOX1(8), APOA1(1), CD36(6), CPT1B(9), CREBBP(24), DUSP1(1), EHHADH(6), EP300(19), FABP1(6), HSD17B4(6), HSPA1A(1), JUN(1), LPL(6), MAPK1(4), MAPK3(3), ME1(22), MRPL11(1), MYC(5), NCOA1(9), NCOR1(23), NCOR2(28), NFKBIA(2), NR0B2(6), NR1H3(4), NR2F1(8), NRIP1(10), PDGFA(1), PIK3CA(10), PIK3R1(3), PPARA(8), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCA(9), PTGS2(13), RB1(10), RELA(4), RXRA(4), SP1(5), STAT5A(3), STAT5B(5), TNF(1)	27018423	322	137	312	164	204	30	22	32	30	4	0.503	1.000	1.000
171	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	33	AKT1(4), APC(27), AR(10), CAMP(2), CCL15(3), CCL16(2), DAG1(9), EGFR(25), GNA11(9), GNA15(7), GNAI1(2), GNAQ(6), ITPKB(11), ITPR1(36), ITPR2(20), ITPR3(12), KCNJ3(21), KCNJ5(13), KCNJ9(6), MAPK1(4), MAPK10(9), MAPK14(5), PHKA2(9), PIK3CA(10), PIK3CD(8), PIK3R1(3), PITX2(6), PTX3(1), RAF1(11), SRC(2)	21993923	293	137	282	176	183	24	16	35	34	1	0.730	1.000	1.000
172	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT1(4), AKT2(8), AKT3(3), ANKRD6(3), APC(27), AXIN1(10), AXIN2(5), CER1(18), CSNK1A1(5), CTNNB1(17), DACT1(13), DKK1(3), DKK2(19), DKK3(4), DKK4(4), DVL1(1), FSTL1(3), GSK3A(1), GSK3B(3), LRP1(47), MVP(10), NKD1(9), NKD2(7), PIN1(1), PSEN1(3), PTPRA(9), SENP2(9), SFRP1(3), TSHB(7), WIF1(7)	17058518	263	137	253	139	155	31	11	31	34	1	0.501	1.000	1.000
173	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	12	C1QA(6), C1QB(7), C1R(16), C1S(20), C2(35), C3(55), C5(23), C6(72), C7(49), C8B(47), C9(22), MASP1(10)	8278889	362	135	327	156	270	17	12	32	27	4	0.00323	1.000	1.000
174	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	42	AKT1(4), AKT2(8), AKT3(3), CAB39(1), EIF4B(6), EIF4EBP1(1), FIGF(5), HIF1A(4), IGF1(11), MAPK1(4), MAPK3(3), PDPK1(5), PGF(1), PIK3CA(10), PIK3CB(10), PIK3CD(8), PIK3CG(28), PIK3R1(3), PIK3R2(6), PIK3R3(2), PIK3R5(17), PRKAA1(1), PRKAA2(32), RHEB(2), RICTOR(13), RPS6(1), RPS6KA1(9), RPS6KA2(6), RPS6KA3(2), RPS6KA6(21), RPS6KB1(4), RPS6KB2(2), STK11(4), TSC1(9), TSC2(14), ULK1(11), ULK2(7), ULK3(1), VEGFA(4), VEGFB(2)	21478262	285	135	270	149	172	25	14	37	35	2	0.510	1.000	1.000
175	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOA(1), ALDOB(14), ALDOC(4), DLAT(4), DLD(3), ENO1(4), ENO2(5), ENO3(4), FBP1(3), FBP2(2), G6PC(5), GAPDH(2), GAPDHS(3), GCK(16), GOT1(6), GOT2(6), GPI(3), HK1(3), HK2(15), HK3(15), LDHA(5), LDHAL6B(6), LDHB(2), LDHC(7), MDH1(3), MDH2(4), PC(14), PCK1(25), PDHA1(4), PDHA2(20), PDHB(1), PDHX(2), PFKL(3), PFKP(2), PGAM2(3), PGK1(3), PGK2(36), PKLR(14), TNFAIP1(2), TPI1(1)	18119057	275	133	260	158	192	20	14	23	26	0	0.0998	1.000	1.000
176	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(9), AADAC(16), ABAT(11), ACADS(5), ACAT2(1), ACSM1(29), AKR1B10(10), ALDH1A3(2), ALDH1B1(11), ALDH2(6), ALDH3A1(10), ALDH3A2(3), ALDH5A1(10), ALDH7A1(10), ALDH9A1(3), BDH1(5), DDHD1(8), ECHS1(3), EHHADH(6), GAD1(14), GAD2(9), HADH(3), HADHA(6), HMGCL(4), HMGCS1(2), HMGCS2(18), HSD17B10(2), HSD17B4(6), HSD3B7(5), ILVBL(5), L2HGDH(4), OXCT1(4), OXCT2(5), PDHA1(4), PDHA2(20), PDHB(1), PLA1A(10), PPME1(1), PRDX6(4), RDH11(2), RDH12(2), RDH13(3), RDH14(1)	17313381	293	133	283	150	197	25	18	22	31	0	0.132	1.000	1.000
177	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	41	AKT1(4), ATF1(5), CAMP(2), CREB5(9), CREBBP(24), CRKL(2), DAG1(9), EGR1(4), EGR2(5), EGR3(4), EGR4(5), ELK1(3), FRS2(7), GNAQ(6), JUN(1), MAP1B(27), MAP2K4(4), MAP2K7(5), MAPK1(4), MAPK10(9), MAPK3(3), MAPK8(2), MAPK8IP1(7), MAPK8IP2(8), MAPK8IP3(9), MAPK9(4), NTRK1(16), OPN1LW(8), PIK3C2G(56), PIK3CA(10), PIK3CD(8), PIK3R1(3), PTPN11(10), RPS6KA3(2), SHC1(2), SRC(2), TERF2IP(2), TH(11)	21156942	302	133	285	166	201	24	13	34	29	1	0.631	1.000	1.000
178	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(66), GABBR1(9), GPRC5A(4), GPRC5B(5), GPRC5C(10), GPRC5D(2), GRM1(13), GRM2(16), GRM3(62), GRM4(22), GRM5(17), GRM7(41), GRM8(47)	8913247	314	132	291	230	230	23	12	23	25	1	0.322	1.000	1.000
179	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(11), ACADM(5), ALDH1A3(2), ALDH1B1(11), ALDH2(6), ALDH3A1(10), ALDH3A2(3), ALDH7A1(10), ALDH9A1(3), AOC2(9), AOC3(9), CNDP1(10), DPYD(73), DPYS(28), ECHS1(3), EHHADH(6), GAD1(14), GAD2(9), HADHA(6), HIBCH(1), MLYCD(2), SMS(5), SRM(1), UPB1(11)	11529012	248	132	225	113	157	21	11	32	27	0	0.0345	1.000	1.000
180	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	13	C1QA(6), C1QB(7), C1R(16), C1S(20), C2(35), C3(55), C5(23), C6(72), C7(49), C9(22), MASP1(10), MASP2(11), MBL2(14)	8493602	340	131	310	144	256	14	9	29	28	4	0.00246	1.000	1.000
181	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	36	BTK(15), CALM1(1), CALM2(1), ELK1(3), FCER1A(17), FCER1G(1), FOS(2), GRB2(2), HRAS(3), JUN(1), LYN(11), MAP2K4(4), MAP2K7(5), MAP3K1(4), MAPK1(4), MAPK3(3), MAPK8(2), NFATC1(17), NFATC2(12), NFATC3(11), NFATC4(18), PAK2(9), PIK3CA(10), PIK3R1(3), PLA2G4A(16), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), RAF1(11), SHC1(2), SOS1(10), SYK(15), SYT1(23), VAV1(19)	17975399	275	131	264	134	169	19	13	37	34	3	0.571	1.000	1.000
182	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(6), ACAA2(1), ACAD8(3), ACAD9(2), ADH1A(17), ADH1B(30), ADH4(12), ADH5(3), ADH6(14), ADH7(16), ADHFE1(6), AKR1B10(10), AKR1C4(10), AKR1D1(21), ALDH1A3(2), ALDH1B1(11), ALDH2(6), ALDH3A1(10), ALDH3A2(3), ALDH7A1(10), ALDH9A1(3), BAAT(14), CEL(13), CYP27A1(4), CYP7A1(8), HADHB(6), HSD3B7(5), LIPA(5), RDH11(2), RDH12(2), RDH13(3), RDH14(1), SLC27A5(10), SOAT1(3), SOAT2(6), SRD5A1(2)	13517370	280	131	249	128	182	29	22	21	25	1	0.00507	1.000	1.000
183	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(23), ACACB(23), ACAT2(1), ACOT12(15), ACSS1(2), ACSS2(4), ACYP1(1), AKR1B1(2), ALDH1A3(2), ALDH1B1(11), ALDH2(6), ALDH3A1(10), ALDH3A2(3), ALDH7A1(10), ALDH9A1(3), DLAT(4), DLD(3), GLO1(1), GRHPR(1), HAGH(3), LDHA(5), LDHAL6A(6), LDHAL6B(6), LDHB(2), LDHC(7), LDHD(1), MDH1(3), MDH2(4), ME1(22), ME2(2), ME3(8), PC(14), PCK1(25), PCK2(6), PDHA1(4), PDHA2(20), PDHB(1), PKLR(14)	19964758	278	131	268	158	180	17	19	31	30	1	0.504	1.000	1.000
184	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	A4GALT(7), B3GALNT1(6), B3GALT1(15), B3GALT2(1), B3GALT4(2), B3GALT5(1), B3GNT1(3), B3GNT2(2), B3GNT3(7), B3GNT4(4), B3GNT5(2), B4GALNT1(5), B4GALT1(2), B4GALT2(2), B4GALT3(3), B4GALT4(3), B4GALT6(2), FUT1(4), FUT2(4), FUT3(8), FUT4(3), FUT5(8), FUT6(4), FUT7(2), FUT9(29), GBGT1(3), GCNT2(1), PIGA(2), PIGB(3), PIGC(3), PIGF(2), PIGG(9), PIGH(2), PIGK(7), PIGL(3), PIGM(2), PIGN(3), PIGO(15), PIGQ(9), PIGS(1), PIGT(1), PIGU(7), PIGV(9), PIGX(2), PIGZ(4), ST3GAL1(8), ST3GAL2(1), ST3GAL3(2), ST3GAL4(1), ST3GAL5(3), ST3GAL6(4), ST6GALNAC3(7), ST6GALNAC4(4), ST6GALNAC5(10), ST6GALNAC6(2), ST8SIA1(1), ST8SIA5(12), UGCG(1)	20619833	273	131	265	153	153	30	14	45	30	1	0.344	1.000	1.000
185	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B3GNT6(2), B4GALT5(3), C1GALT1(7), C1GALT1C1(3), GALNT1(4), GALNT10(7), GALNT11(3), GALNT12(8), GALNT13(31), GALNT14(30), GALNT2(7), GALNT3(4), GALNT4(5), GALNT5(13), GALNT6(16), GALNT7(4), GALNT8(28), GALNT9(7), GALNTL5(17), GCNT1(6), GCNT3(8), GCNT4(3), OGT(9), ST3GAL1(8), ST3GAL2(1), ST6GALNAC1(8), WBSCR17(46)	13764968	288	130	271	135	198	14	7	32	37	0	0.0973	1.000	1.000
186	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	65	APAF1(6), BAK1(2), BAX(4), BCL2(3), BCL2L11(8), BIRC2(6), BIRC3(7), BIRC5(3), BNIP3L(1), CASP1(4), CASP10(6), CASP2(1), CASP3(2), CASP4(2), CASP7(4), CASP8(9), CASP9(2), CHUK(2), CYCS(1), DFFA(2), DFFB(2), FAS(5), FASLG(15), GZMB(3), HELLS(6), IKBKB(4), IRF1(2), IRF2(6), IRF3(3), IRF4(2), IRF5(5), IRF6(14), IRF7(5), JUN(1), LTA(5), MAP2K4(4), MAP3K1(4), MAPK10(9), MDM2(4), MYC(5), NFKB1(6), NFKBIA(2), NFKBIB(1), PLEKHG5(12), PRF1(14), RELA(4), RIPK1(3), TNF(1), TNFRSF10B(5), TNFRSF1A(4), TNFRSF1B(4), TNFRSF21(14), TNFRSF25(6), TNFSF10(9), TP73(6), TRAF1(6), TRAF2(2), TRAF3(5)	24040874	283	128	278	163	179	29	14	29	31	1	0.748	1.000	1.000
187	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(27), ATP4A(17), ATP4B(1), ATP5A1(2), ATP5B(1), ATP5C1(3), ATP5F1(7), ATP5G2(2), ATP5H(2), ATP5J(2), ATP5O(5), ATP6AP1(3), ATP6V0A1(13), ATP6V0A2(5), ATP6V0A4(23), ATP6V0C(1), ATP6V0D1(1), ATP6V0D2(9), ATP6V0E1(1), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1E2(3), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(7), ATP6V1H(5), COX10(7), COX15(4), COX4I2(4), COX5B(1), COX6A1(1), COX6B1(2), COX6C(1), COX7B(1), COX7B2(3), COX8A(1), COX8C(2), CYC1(4), LHPP(1), NDUFA10(4), NDUFA12(1), NDUFA13(2), NDUFA4(1), NDUFA9(2), NDUFAB1(1), NDUFB2(3), NDUFB3(1), NDUFB5(3), NDUFB6(2), NDUFB7(2), NDUFC2(2), NDUFS1(2), NDUFS2(3), NDUFS3(4), NDUFS4(3), NDUFS5(1), NDUFS6(2), NDUFS7(3), NDUFS8(3), NDUFV1(1), NDUFV2(1), PPA1(1), PPA2(4), SDHA(4), SDHC(3), SDHD(1), TCIRG1(6), UQCRC1(4), UQCRC2(3), UQCRFS1(3)	23869939	268	128	261	143	153	23	16	43	30	3	0.427	1.000	1.000
188	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	36	AGT(8), AGTR2(10), CALM1(1), CALM2(1), CAMK2A(6), CAMK2B(6), CAMK2D(6), CAMK2G(5), CDK5(6), F2(13), FYN(8), GNA11(9), GNAI1(2), GNB1(1), GRB2(2), HRAS(3), JAK2(8), MAP2K2(5), MAPK1(4), MAPK14(5), MAPK3(3), MAPK8(2), MAPT(10), MYLK(48), PLCG1(9), PRKCA(9), PTK2B(12), RAF1(11), SHC1(2), SOS1(10), STAT1(5), STAT3(11), STAT5A(3), SYT1(23)	17336401	267	127	253	162	164	22	13	34	32	2	0.803	1.000	1.000
189	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	10	C1QA(6), C1QB(7), C1R(16), C1S(20), C2(35), C3(55), C5(23), C6(72), C7(49), C9(22)	6873265	305	127	277	129	229	13	8	28	23	4	0.00572	1.000	1.000
190	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(39), AR(10), ESR1(6), ESR2(10), ESRRA(3), HNF4A(23), NPM1(4), NR0B1(3), NR1D1(1), NR1D2(11), NR1H2(5), NR1H3(4), NR1I2(5), NR1I3(6), NR2C2(1), NR2E1(5), NR2F1(8), NR2F2(2), NR2F6(1), NR3C1(7), NR4A1(4), NR4A2(4), NR5A1(10), NR5A2(23), PGR(16), PPARA(8), PPARD(3), PPARG(12), RARA(4), RARB(9), RARG(3), ROR1(15), RORA(2), RORC(15), RXRA(4), RXRB(4), RXRG(6), THRA(2), THRB(18), VDR(3)	17788226	319	127	304	166	222	26	10	25	36	0	0.0936	1.000	1.000
191	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	31	ACTR2(3), ACTR3(2), AKT1(4), ANGPTL2(3), DAG1(9), DGKA(3), ETFA(3), GCA(3), ITGA9(15), ITPKB(11), ITPR1(36), ITPR2(20), ITPR3(12), MAPK1(4), MAPK3(3), NR1I3(6), PAK1(4), PDE3A(30), PDE3B(6), PI3(6), PIK3C2G(56), PIK3CA(10), PIK3CD(8), PIK3R1(3), RIPK3(10), VASP(3)	20315694	273	127	255	129	186	22	12	24	28	1	0.0190	1.000	1.000
192	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(9), ALPL(11), ALPP(9), ALPPL2(12), ASCC3(16), ATP13A2(13), DDX18(5), DDX19A(1), DDX23(7), DDX4(13), DDX41(8), DDX47(1), DDX50(5), DDX51(5), DDX52(4), DDX54(3), DDX55(2), DDX56(3), DHFR(1), DHX58(3), ENTPD7(2), EP400(28), ERCC2(3), ERCC3(6), FPGS(3), GGH(4), IFIH1(10), MOV10L1(24), NUDT5(1), NUDT8(2), QDPR(3), RAD54B(8), RUVBL2(5), SETX(19), SKIV2L2(6), SMARCA2(14), SMARCA5(5), SPR(4)	26610983	278	126	268	158	177	18	17	27	38	1	0.736	1.000	1.000
193	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(12), ALOX12(6), ALOX15(10), ALOX5(14), CBR3(1), CYP4F2(17), CYP4F3(25), EPX(9), GGT1(8), LPO(20), LTA4H(5), MPO(12), PLA2G1B(1), PLA2G2A(2), PLA2G2E(5), PLA2G3(19), PLA2G4A(16), PLA2G5(2), PLA2G6(13), PRDX1(3), PRDX2(3), PRDX6(4), PTGDS(3), PTGES2(1), PTGIS(18), PTGS1(20), PTGS2(13), TBXAS1(16), TPO(47)	11883679	325	126	316	181	223	29	5	25	42	1	0.0235	1.000	1.000
194	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(5), AASDHPPT(3), AASS(3), ACAT2(1), AKR1B10(10), ALDH1A3(2), ALDH1B1(11), ALDH2(6), ALDH3A1(10), ALDH3A2(3), ALDH7A1(10), ALDH9A1(3), BBOX1(7), DLST(1), DOT1L(12), ECHS1(3), EHHADH(6), EHMT1(11), EHMT2(9), GCDH(6), HADH(3), HADHA(6), HSD17B10(2), HSD17B4(6), HSD3B7(5), NSD1(21), OGDH(9), OGDHL(44), PIPOX(7), PLOD1(6), PLOD2(7), PLOD3(5), RDH11(2), RDH12(2), RDH13(3), RDH14(1), SETD1A(27), SETD7(2), SETDB1(10), SHMT1(2), SHMT2(3), SUV39H1(1), SUV39H2(2), TMLHE(2)	24660651	300	124	291	151	193	26	16	39	25	1	0.184	1.000	1.000
195	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(6), ARG1(2), ARG2(2), ASL(7), ASS1(8), CKM(3), CKMT1A(1), CKMT2(5), CPS1(29), DAO(12), EPRS(13), GAMT(4), GATM(6), GLUD1(2), GLUD2(4), GOT1(6), GOT2(6), LAP3(2), NOS1(77), NOS3(20), OAT(4), OTC(4), P4HA1(10), P4HA2(5), P4HA3(14), PRODH(2), PYCR1(1), PYCR2(1), RARS(7), RARS2(4)	15270113	267	124	253	144	177	26	11	19	32	2	0.208	1.000	1.000
196	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ACY3(4), ALDH1A3(2), ALDH1B1(11), ALDH2(6), ALDH3A1(10), ALDH3A2(3), ALDH3B1(3), ALDH3B2(8), ALDH7A1(10), ALDH9A1(3), AMDHD1(6), AOC2(9), AOC3(9), ASPA(3), CARM1(7), CNDP1(10), DDC(16), FTCD(3), HAL(14), HARS(8), HARS2(4), HDC(25), HEMK1(4), HNMT(2), LCMT1(4), LCMT2(1), MAOA(4), MAOB(13), METTL2B(5), METTL6(2), PRMT2(2), PRMT3(5), PRMT5(7), PRMT7(4), PRMT8(10), PRPS1(3), PRPS2(3), UROC1(13), WBSCR22(2)	16840005	258	124	248	165	157	23	14	27	35	2	0.669	1.000	1.000
197	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(3), ADRBK2(7), ARRB2(7), CALM1(1), CALM2(1), CALML3(9), CALML6(1), CAMK2A(6), CAMK2B(6), CAMK2D(6), CAMK2G(5), CLCA1(8), CLCA2(9), CLCA4(30), CNGA3(25), CNGA4(18), CNGB1(23), GNAL(2), GUCA1A(6), GUCA1B(2), GUCA1C(9), PDC(6), PDE1C(54), PRKACA(3), PRKACB(4), PRKACG(10), PRKG1(14), PRKG2(16), PRKX(3)	12882005	294	124	274	163	198	23	9	30	34	0	0.189	1.000	1.000
198	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	33	ACTA1(4), CRK(3), CRKL(2), DOCK1(17), ELK1(3), FOS(2), GAB1(8), GRB2(2), HGF(30), HRAS(3), ITGA1(23), ITGB1(4), JUN(1), MAP2K2(5), MAP4K1(12), MAPK1(4), MAPK3(3), MAPK8(2), MET(23), PAK1(4), PIK3CA(10), PIK3R1(3), PTK2(7), PTK2B(12), PTPN11(10), PXN(2), RAF1(11), RAP1A(1), RAP1B(1), RASA1(5), SOS1(10), SRC(2), STAT3(11)	17944707	240	124	231	134	140	22	9	40	28	1	0.956	1.000	1.000
199	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1A(13), ADRA1B(5), ADRA1D(4), ADRA2A(3), ADRA2C(2), ADRB1(5), ADRB2(4), CHRM1(5), CHRM2(26), CHRM3(26), CHRM4(6), CHRM5(7), DRD1(9), DRD2(16), DRD3(5), DRD4(1), DRD5(25), HRH1(15), HRH2(3), HTR1A(11), HTR1B(2), HTR1D(7), HTR1E(7), HTR1F(9), HTR2A(11), HTR2B(2), HTR2C(14), HTR4(8), HTR5A(19), HTR6(3), HTR7(10)	10790072	283	124	260	227	183	33	11	29	26	1	0.194	1.000	1.000
200	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	47	AKT1(4), AKT2(8), AKT3(3), BRD4(23), CAP1(1), CBL(10), CDC42(2), F2RL2(8), FLOT1(1), GRB2(2), GSK3A(1), GSK3B(3), IGFBP1(3), INPPL1(16), IRS1(5), IRS2(3), IRS4(11), LNPEP(11), MAPK1(4), MAPK3(3), PARD3(20), PARD6A(1), PDK1(2), PIK3CA(10), PIK3CD(8), PIK3R1(3), PTPN1(4), RAF1(11), RPS6KA1(9), RPS6KA2(6), RPS6KA3(2), RPS6KB1(4), SERPINB6(5), SFN(2), SHC1(2), SLC2A4(8), SORBS1(16), SOS1(10), SOS2(13), YWHAB(1), YWHAE(2), YWHAG(2), YWHAQ(3)	24841631	266	124	259	138	147	33	14	43	28	1	0.674	1.000	1.000
201	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(4), AKT2(8), AKT3(3), ARHGEF11(22), BCL2(3), CDC42(2), DLG4(6), GNA13(1), LPA(59), MAP2K4(4), MAP3K1(4), MAP3K5(23), MAPK8(2), NFKB1(6), NFKB2(5), NFKBIA(2), NFKBIB(1), NFKBIL1(2), PDK1(2), PHKA2(9), PI3(6), PIK3CB(10), PLD1(14), PLD2(8), PLD3(1), PTK2(7), RDX(4), ROCK1(6), ROCK2(14), SERPINA4(22), SRF(3), TBXA2R(4)	20876814	267	124	254	153	153	23	11	43	37	0	0.888	1.000	1.000
202	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(6), ACAA2(1), ADH1A(17), ADH1B(30), ADH4(12), ADH6(14), ADH7(16), ADHFE1(6), AKR1C4(10), AKR1D1(21), ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(6), ALDH3A1(10), ALDH3A2(3), ALDH9A1(3), BAAT(14), CEL(13), CYP27A1(4), CYP7A1(8), HADHB(6), SOAT2(6), SRD5A1(2)	9931614	244	123	216	101	164	19	15	22	23	1	0.00129	1.000	1.000
203	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	20	CCL11(3), CCR3(11), CFL1(2), GNAQ(6), GNAS(33), GNB1(1), HRAS(3), LIMK1(5), MAPK1(4), MAPK3(3), MYL2(9), NOX1(13), PIK3C2G(56), PLCB1(58), PPP1R12B(9), PRKCA(9), PTK2(7), RAF1(11), ROCK2(14)	10337466	257	123	230	92	176	15	7	34	25	0	0.00278	1.000	1.000
204	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	ACTG1(7), APAF1(6), ARHGDIB(4), BAG4(3), BCL2(3), BIRC2(6), BIRC3(7), CASP2(1), CASP3(2), CASP7(4), CASP8(9), CASP9(2), CFLAR(4), CHUK(2), CRADD(2), CYCS(1), DAXX(10), DFFA(2), DFFB(2), GSN(6), LMNA(5), LMNB1(2), LMNB2(4), MAP2K7(5), MAP3K1(4), MAP3K5(23), MAPK8(2), MDM2(4), NFKB1(6), NFKBIA(2), NUMA1(9), PAK2(9), PRKCD(5), PRKDC(22), PSEN1(3), PSEN2(2), PTK2(7), RASA1(5), RB1(10), RELA(4), RIPK1(3), SPTAN1(10), TNF(1), TNFRSF1A(4), TNFRSF1B(4), TRAF1(6), TRAF2(2)	29446534	246	121	240	134	120	26	15	45	37	3	0.789	1.000	1.000
205	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	32	BLNK(15), BTK(15), CALM1(1), CALM2(1), CD79A(4), ELK1(3), FOS(2), GRB2(2), HRAS(3), JUN(1), LYN(11), MAP3K1(4), MAPK14(5), MAPK3(3), MAPK8(2), NFATC1(17), NFATC2(12), NFATC3(11), NFATC4(18), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKCA(9), RAF1(11), SHC1(2), SOS1(10), SYK(15), SYT1(23), VAV1(19)	15779976	239	120	229	122	154	16	9	29	29	2	0.623	1.000	1.000
206	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(23), ACAT2(1), ACYP1(1), ADH5(3), AKR1B1(2), ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(6), ALDH3A1(10), ALDH3A2(3), ALDH9A1(3), DLAT(4), DLD(3), GLO1(1), GRHPR(1), HAGH(3), LDHA(5), LDHB(2), LDHC(7), LDHD(1), MDH1(3), MDH2(4), ME1(22), ME2(2), ME3(8), PC(14), PCK1(25), PDHA1(4), PDHA2(20), PDHB(1), PKLR(14)	15779632	232	120	223	124	156	15	13	25	22	1	0.374	1.000	1.000
207	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	21	ARFIP2(2), CDK5(6), CDK5R1(1), CFL1(2), CHN1(7), LIMK1(5), MAP3K1(4), MYL2(9), MYLK(48), NCF2(8), PAK1(4), PDGFRA(32), PIK3CA(10), PIK3R1(3), PLD1(14), PPP1R12B(9), RALBP1(3), RPS6KB1(4), TRIO(22), VAV1(19), WASF1(5)	14739970	217	120	206	118	136	15	9	27	28	2	0.622	1.000	1.000
208	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	ACVR1(2), APC(27), ATF2(6), AXIN1(10), BMP10(14), BMP2(7), BMP4(5), BMP5(33), BMP7(5), BMPR1A(2), BMPR2(7), CHRD(21), CTNNB1(17), DVL1(1), FZD1(5), GATA4(5), GSK3B(3), MAP3K7(1), MEF2C(3), MYL2(9), NKX2-5(1), NOG(2), NPPA(5), NPPB(6), RFC1(5), TGFB1(2), TGFB2(3), TGFB3(3), TGFBR2(9), TGFBR3(9), WNT1(2)	15445587	230	119	212	104	147	20	10	22	31	0	0.254	1.000	1.000
209	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSD(3), ARSE(5), B4GALT6(2), CERK(1), DEGS1(2), DEGS2(5), ENPP7(6), GAL3ST1(11), GALC(3), GBA(7), GLA(2), GLB1(10), LCT(54), NEU1(6), NEU2(19), NEU3(4), NEU4(16), PPAP2B(11), PPAP2C(8), SGMS1(18), SGMS2(1), SGPP1(2), SGPP2(6), SMPD1(2), SMPD2(2), SMPD3(9), SMPD4(6), SPHK1(2), SPHK2(8), SPTLC1(2), SPTLC2(8), UGCG(1), UGT8(8)	15130294	250	119	243	166	173	17	6	30	24	0	0.893	1.000	1.000
210	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	41	BCL2(3), CHUK(2), DAXX(10), EGF(22), EGFR(25), ETS1(4), ETS2(8), FOS(2), HOXA7(2), HRAS(3), IKBKB(4), JUN(1), MAP2K3(9), MAP2K4(4), MAP2K6(3), MAP2K7(5), MAP3K1(4), MAP3K5(23), MAPK1(4), MAPK13(5), MAPK14(5), MAPK3(3), MAPK8(2), NFKB1(6), NFKBIA(2), PPP2CA(1), PRKCA(9), PRKCD(5), PRKCE(7), PRKCG(16), PRKCH(9), PRKCQ(21), RAF1(11), RELA(4), RIPK1(3), SP1(5), TNF(1), TNFRSF1A(4), TNFRSF1B(4), TRAF2(2)	20536783	263	119	256	168	158	25	9	30	41	0	0.932	1.000	1.000
211	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	40	CALM1(1), CALM2(1), CD3D(7), CD3E(2), CD3G(1), ELK1(3), FOS(2), FYN(8), GRB2(2), HRAS(3), JUN(1), LAT(3), LCK(15), MAP2K4(4), MAP3K1(4), MAPK3(3), MAPK8(2), NFATC1(17), NFATC2(12), NFATC3(11), NFATC4(18), NFKB1(6), NFKBIA(2), PIK3CA(10), PIK3R1(3), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKCA(9), PTPN7(2), RAF1(11), RASA1(5), RELA(4), SHC1(2), SOS1(10), SYT1(23), VAV1(19), ZAP70(8)	19831741	254	118	245	125	156	27	10	31	27	3	0.564	1.000	1.000
212	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	ARNT(9), EIF2B1(1), EIF2B2(1), EIF2B3(3), EIF2B4(1), EIF2B5(3), EIF2S1(1), EIF2S3(2), ELAVL1(1), FLT1(42), FLT4(31), HIF1A(4), HRAS(3), KDR(57), NOS3(20), PIK3CA(10), PIK3R1(3), PLCG1(9), PRKCA(9), PTK2(7), PXN(2), SHC1(2), VHL(4)	14545807	225	118	211	114	146	20	3	28	27	1	0.417	1.000	1.000
213	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(19), CALCR(19), CALCRL(19), CD97(7), CRHR1(7), CRHR2(5), ELTD1(27), EMR1(33), EMR2(6), GHRHR(6), GIPR(4), GLP1R(13), GLP2R(15), GPR64(4), LPHN1(7), LPHN2(49), LPHN3(24), SCTR(8), VIPR1(7), VIPR2(7)	11248894	286	117	266	187	203	21	8	16	38	0	0.310	1.000	1.000
214	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(5), ARSB(3), FUCA1(3), GALNS(5), GBA(7), GLB1(10), GNS(2), GUSB(5), HEXA(5), HEXB(4), HGSNAT(5), HPSE(10), HPSE2(5), HYAL1(2), HYAL2(1), IDS(9), IDUA(6), LCT(54), MAN2B1(9), MAN2B2(10), MAN2C1(4), MANBA(7), NAGLU(4), NEU1(6), NEU2(19), NEU3(4), NEU4(16), SPAM1(28)	14580267	248	117	244	136	172	21	5	25	24	1	0.324	1.000	1.000
215	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(5), BLVRA(2), BLVRB(1), CP(14), CPOX(4), EPRS(13), FECH(3), GUSB(5), HCCS(2), HMBS(1), HMOX1(1), HMOX2(1), PPOX(3), UGT1A1(12), UGT1A10(18), UGT1A3(14), UGT1A4(10), UGT1A5(10), UGT1A6(15), UGT1A7(12), UGT1A9(16), UGT2B15(31), UGT2B4(35), UROS(1)	11766354	229	117	208	103	156	20	12	14	25	2	0.0390	1.000	1.000
216	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	28	DPM2(1), EGFR(25), ELK1(3), GNAS(33), GNB1(1), GRB2(2), HRAS(3), IGF1R(15), ITGB1(4), KLK2(5), MAP2K2(5), MAPK1(4), MAPK3(3), MKNK1(6), MKNK2(4), MYC(5), NGFR(8), PDGFRA(32), PPP2CA(1), PTPRR(30), RAF1(11), RPS6KA1(9), RPS6KA5(7), SHC1(2), SOS1(10), SRC(2), STAT3(11)	13708902	242	116	231	111	147	27	12	38	18	0	0.157	1.000	1.000
217	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(11), ACAA1(6), ACAA2(1), ACADM(5), ACADS(5), ACAT2(1), ALDH1A3(2), ALDH1B1(11), ALDH2(6), ALDH3A1(10), ALDH3A2(3), ALDH6A1(4), ALDH7A1(10), ALDH9A1(3), AOX1(29), AUH(2), BCAT1(13), BCAT2(1), BCKDHA(1), BCKDHB(1), DBT(3), DLD(3), ECHS1(3), EHHADH(6), HADH(3), HADHA(6), HADHB(6), HIBADH(5), HIBCH(1), HMGCL(4), HMGCS1(2), HMGCS2(18), HSD17B10(2), HSD17B4(6), IVD(5), MCCC1(5), MCCC2(3), MCEE(2), MUT(5), OXCT1(4), OXCT2(5), PCCA(5), PCCB(3)	18392272	230	116	221	115	148	19	14	25	24	0	0.427	1.000	1.000
218	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(4), ALG10(6), ALG10B(4), ALG11(5), ALG12(1), ALG13(10), ALG14(2), ALG2(5), ALG3(4), ALG5(3), ALG6(2), ALG8(7), ALG9(5), B4GALT1(2), B4GALT2(2), B4GALT3(3), DAD1(1), DDOST(2), DHDDS(1), DOLPP1(3), DPAGT1(2), DPM1(1), FUT8(8), GANAB(6), MAN1A1(19), MAN1A2(7), MAN1B1(4), MAN1C1(11), MAN2A1(10), MGAT1(3), MGAT2(3), MGAT3(12), MGAT4A(8), MGAT4B(1), MGAT5(6), MGAT5B(11), RFT1(5), RPN2(4), ST6GAL1(8), STT3B(5)	18038343	206	116	199	109	120	22	14	21	28	1	0.285	1.000	1.000
219	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	5	C3(55), C5(23), C6(72), C7(49), C9(22)	4796342	221	115	195	88	165	6	6	21	19	4	0.0108	1.000	1.000
220	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	26	AKT1(4), APC(27), AXIN1(10), CCND1(2), CD14(6), CTNNB1(17), DVL1(1), FZD1(5), GJA1(10), GNAI1(2), GSK3B(3), IRAK1(5), LBP(10), LEF1(3), LY96(4), MYD88(1), NFKB1(6), PDPK1(5), PIK3CA(10), PIK3R1(3), PPP2CA(1), RELA(4), TIRAP(1), TLR4(42), TOLLIP(1), WNT1(2)	12985566	185	115	176	97	114	16	11	22	20	2	0.687	1.000	1.000
221	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA1(7), ANXA2(2), ANXA3(4), ANXA4(2), ANXA5(1), ANXA6(6), CYP11A1(14), EDN1(9), EDNRA(11), EDNRB(7), HPGD(1), HSD11B1(14), HSD11B2(2), PLA2G4A(16), PRL(3), PTGDR(12), PTGDS(3), PTGER2(7), PTGER4(3), PTGFR(21), PTGIR(5), PTGIS(18), PTGS1(20), PTGS2(13), S100A6(1), SCGB1A1(1), TBXAS1(16)	8729408	219	115	210	88	149	22	6	19	22	1	0.000106	1.000	1.000
222	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(3), ACTR3(2), ARHGAP1(3), ARHGAP4(4), ARHGAP5(13), ARHGAP6(10), ARHGEF1(1), ARHGEF11(22), ARHGEF5(17), ARPC1B(3), ARPC2(1), ARPC3(2), ARPC4(1), BAIAP2(8), CFL1(2), DIAPH1(10), GSN(6), LIMK1(5), MYL2(9), MYLK(48), OPHN1(4), PIP5K1A(6), PIP5K1B(21), PPP1R12B(9), ROCK1(6), SRC(2), TLN1(12), VCL(9)	19184854	239	115	229	125	170	13	10	23	23	0	0.168	1.000	1.000
223	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	36	AGXT(12), ALAS1(2), ALAS2(6), AMT(1), AOC2(9), AOC3(9), ATP6V0C(1), BHMT(8), CBS(7), CHDH(8), CHKA(2), CHKB(3), CPT1B(9), CTH(1), DAO(12), DLD(3), DMGDH(16), GAMT(4), GARS(6), GATM(6), GCAT(4), GLDC(6), MAOA(4), MAOB(13), PEMT(2), PISD(2), PLCB2(12), PLCG1(9), PLCG2(30), PSPH(2), SARDH(20), SARS(5), SHMT1(2), SHMT2(3), TARS(5)	17475585	244	114	237	155	162	19	11	19	33	0	0.568	1.000	1.000
224	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2A1(2), GTF2A1L(18), GTF2A2(1), GTF2B(5), GTF2E1(3), GTF2E2(6), GTF2F1(5), GTF2F2(2), GTF2H1(3), GTF2H3(1), GTF2H4(2), GTF2I(2), GTF2IRD1(12), STON1(22), TAF1(14), TAF13(1), TAF1L(57), TAF2(9), TAF4(11), TAF4B(7), TAF5L(4), TAF6(3), TAF6L(4), TAF7(3), TAF7L(12), TAF9(2), TAF9B(1), TBPL1(1), TBPL2(7)	15433182	220	113	213	96	151	17	9	24	19	0	0.239	1.000	1.000
225	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	22	ATF2(6), BCR(14), BLNK(15), ELK1(3), FOS(2), GRB2(2), HRAS(3), JUN(1), LYN(11), MAP3K1(4), MAPK1(4), MAPK3(3), MAPK8IP3(9), PAPPA(59), RPS6KA1(9), RPS6KA3(2), SHC1(2), SOS1(10), SYK(15), VAV1(19), VAV2(5), VAV3(11)	13063413	209	113	200	144	142	16	4	21	24	2	0.982	1.000	1.000
226	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(6), CAMK2B(6), CAMK2D(6), CAMK2G(5), DAG1(9), ITPKB(11), ITPR1(36), ITPR2(20), ITPR3(12), NFAT5(11), PDE6A(15), PDE6B(16), PDE6C(25), PDE6D(2), PDE6G(2), SLC6A13(30), TF(16)	15180327	228	113	213	135	156	11	6	19	36	0	0.209	1.000	1.000
227	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CD14(6), CHUK(2), ELK1(3), FOS(2), IKBKB(4), IRAK1(5), JUN(1), LY96(4), MAP2K3(9), MAP2K4(4), MAP2K6(3), MAP3K1(4), MAP3K7(1), MAPK14(5), MAPK8(2), MYD88(1), NFKB1(6), NFKBIA(2), PPARA(8), RELA(4), TIRAP(1), TLR10(13), TLR2(15), TLR3(11), TLR4(42), TLR6(7), TLR7(17), TLR9(14), TOLLIP(1), TRAF6(4)	15464628	201	113	194	101	134	19	8	21	19	0	0.212	1.000	1.000
228	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	33	ADCY1(34), CALM1(1), CALM2(1), ELK1(3), FOS(2), GNAI1(2), GNAQ(6), GNAS(33), GNB1(1), HRAS(3), JUN(1), MAPK3(3), NFATC1(17), NFATC2(12), NFATC3(11), NFATC4(18), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCA(9), RAF1(11), RPS6KA3(2), SYT1(23)	14507453	240	112	227	128	150	25	13	28	23	1	0.630	1.000	1.000
229	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(4), AARS2(3), CARS(9), CARS2(4), DARS(4), DARS2(3), EARS2(2), EPRS(13), FARS2(6), FARSA(8), FARSB(5), GARS(6), HARS(8), HARS2(4), IARS(10), IARS2(18), KARS(4), LARS(13), LARS2(5), MARS(8), MARS2(4), MTFMT(2), NARS(2), NARS2(6), QARS(6), RARS(7), RARS2(4), SARS(5), SARS2(3), TARS(5), TARS2(7), VARS(16), VARS2(7), WARS(5), WARS2(4), YARS(3), YARS2(2)	23310231	225	112	213	124	132	24	9	25	33	2	0.680	1.000	1.000
230	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(15), DLG4(6), EPHB2(36), F2(13), F2RL1(9), F2RL2(8), F2RL3(5), JUN(1), MAP2K5(5), MAPK1(4), MAPK7(4), MAPK8(2), MYEF2(4), PLD1(14), PLD2(8), PLD3(1), PTK2(7), RAF1(11), RASAL1(18), SRC(2), TEC(13), VAV1(19)	11671726	205	112	197	142	120	23	6	30	23	3	0.971	1.000	1.000
231	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	32	AARS(4), AARS2(3), ABAT(11), ACY3(4), ADSL(6), ADSS(2), ADSSL1(9), AGXT(12), ASL(7), ASNS(9), ASPA(3), ASRGL1(6), ASS1(8), CAD(18), CRAT(5), DARS(4), DARS2(3), DDO(9), DLAT(4), DLD(3), GAD1(14), GAD2(9), GOT1(6), GOT2(6), GPT(4), GPT2(2), NARS(2), NARS2(6), PC(14), PDHA1(4), PDHA2(20), PDHB(1)	15732636	218	111	210	124	144	22	12	18	22	0	0.383	1.000	1.000
232	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ALDH1A3(2), ALDH3A1(10), ALDH3B1(3), ALDH3B2(8), AOC2(9), AOC3(9), DDC(16), EPX(9), GOT1(6), GOT2(6), HPD(7), LPO(20), MAOA(4), MAOB(13), MPO(12), PRDX1(3), PRDX2(3), PRDX6(4), TAT(21), TPO(47)	9341657	212	111	206	144	145	21	7	12	27	0	0.517	1.000	1.000
233	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(25), CD2(29), CD33(21), CD5(8), CD7(2), CSF2(2), IFNA1(1), IFNB1(6), IFNG(4), IL10(2), IL12A(4), IL12B(3), IL13(2), IL3(3), IL4(1), IL5(4), ITGAX(25), TLR2(15), TLR4(42), TLR7(17), TLR9(14)	7912106	230	110	213	118	162	21	10	14	23	0	0.000537	1.000	1.000
234	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(36), ACE2(6), AGT(8), AGTR1(10), AGTR2(10), ANPEP(25), CMA1(6), CPA3(23), CTSA(4), CTSG(5), ENPEP(46), LNPEP(11), MAS1(4), MME(25), NLN(5), REN(12), THOP1(6)	8991146	242	110	226	123	168	20	11	14	28	1	0.0250	1.000	1.000
235	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	34	ACTA1(4), ACTN1(8), ACTN2(21), BCAR1(5), BCR(14), CAPN1(5), CAPNS1(2), CAPNS2(1), CAV1(1), CRKL(2), CSK(1), FYN(8), GRB2(2), HRAS(3), ITGA1(23), ITGB1(4), JUN(1), MAP2K2(5), MAPK1(4), MAPK3(3), MAPK8(2), PPP1R12B(9), PTK2(7), PXN(2), RAF1(11), RAP1A(1), ROCK1(6), SHC1(2), SOS1(10), SRC(2), TLN1(12), VCL(9), ZYX(8)	19573048	198	110	194	113	104	26	12	29	26	1	0.689	1.000	1.000
236	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(2), GUSB(5), UCHL1(5), UCHL3(2), UGDH(1), UGT1A1(12), UGT1A10(18), UGT1A3(14), UGT1A4(10), UGT1A5(10), UGT1A6(15), UGT1A7(12), UGT1A9(16), UGT2B15(31), UGT2B4(35)	7546020	188	110	164	92	133	17	11	8	18	1	0.0607	1.000	1.000
237	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT1(4), AKT2(8), AKT3(3), CISH(4), GRB2(2), IARS(10), IL13RA1(4), IL2RG(3), IL4(1), IL4R(18), INPP5D(36), JAK1(7), JAK2(8), JAK3(11), NR0B2(6), PI3(6), PIK3CA(10), PPP1R13B(9), RPS6KB1(4), SERPINA4(22), SHC1(2), SOS1(10), SOS2(13), SRC(2), STAT6(9), TYK2(8)	15692547	220	110	209	110	142	17	9	29	22	1	0.462	1.000	1.000
238	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(6), ACAA2(1), ACADL(5), ACADM(5), ACADS(5), ACADSB(6), ACAT2(1), ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(6), ALDH3A1(10), ALDH3A2(3), ALDH6A1(4), ALDH9A1(3), AOX1(29), BCAT1(13), BCKDHA(1), BCKDHB(1), ECHS1(3), EHHADH(6), HADHA(6), HADHB(6), HIBADH(5), HMGCL(4), IVD(5), MCCC1(5), MCCC2(3), MCEE(2), MUT(5), OXCT1(4), PCCA(5), PCCB(3), SDS(3)	15396124	200	110	191	101	130	15	10	22	23	0	0.444	1.000	1.000
239	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ALDH1A3(2), ALDH3A1(10), ALDH3B1(3), ALDH3B2(8), AOC2(9), AOC3(9), DDC(16), EPX(9), ESCO1(2), ESCO2(4), GOT1(6), GOT2(6), HPD(7), LPO(20), MAOA(4), MAOB(13), MPO(12), NAT6(5), PNPLA3(3), PRDX6(4), SH3GLB1(2), TAT(21), TPO(47)	14603732	222	109	216	157	151	20	11	14	26	0	0.954	1.000	1.000
240	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(11), ALDH1A3(2), ALDH1B1(11), ALDH2(6), ALDH3A1(10), ALDH3A2(3), ALDH7A1(10), ALDH9A1(3), CYP2C19(40), CYP2C9(41), DHRS1(3), DHRS2(8), DHRS3(5), DHRS7(1), DHRSX(6), ECHS1(3), EHHADH(6), ESCO1(2), ESCO2(4), HADHA(6), NAT6(5), PNPLA3(3), SH3GLB1(2), YOD1(1)	13220609	192	109	181	122	119	20	14	17	22	0	0.918	1.000	1.000
241	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	20	F2(13), F2R(8), F2RL3(5), GNAI1(2), GNB1(1), HRAS(3), ITGA1(23), ITGB1(4), MAPK1(4), MAPK3(3), PLA2G4A(16), PLCB1(58), PRKCA(9), PTGS1(20), PTK2(7), RAF1(11), SRC(2), SYK(15), TBXAS1(16)	10041621	220	108	206	99	147	18	6	24	24	1	0.0720	1.000	1.000
242	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(16), CARM1(7), CCND1(2), CREBBP(24), EP300(19), ERCC3(6), ESR1(6), GRIP1(13), GTF2A1(2), GTF2E1(3), GTF2F1(5), HDAC1(2), HDAC2(2), HDAC3(5), HDAC4(11), HDAC5(6), HDAC6(3), MEF2C(3), NCOR2(28), NR0B1(3), NRIP1(10), PELP1(12), POLR2A(13), TBP(4)	19402795	205	107	203	95	131	11	12	34	17	0	0.311	1.000	1.000
243	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	21	ADCY1(34), AKT1(4), GNAI1(2), GNB1(1), ITGAV(11), ITGB3(16), MAPK1(4), MAPK3(3), PDGFA(1), PDGFRA(32), PIK3CA(10), PIK3R1(3), PLCB1(58), PRKCA(9), PTK2(7), SMPD1(2), SMPD2(2), SPHK1(2), SRC(2)	11555407	203	107	193	94	143	12	7	22	18	1	0.0804	1.000	1.000
244	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(7), ACTG2(6), ADCY3(3), ADCY9(11), AK1(1), ARF4(3), ARF5(2), ARF6(1), ARL4D(2), ATP6V0A1(13), ATP6V0A2(5), ATP6V0A4(23), ATP6V0C(1), ATP6V0D1(1), ATP6V0D2(9), ATP6V0E1(1), ATP6V1A(2), ATP6V1C2(8), ATP6V1E1(1), ATP6V1E2(3), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(7), ATP6V1H(5), ERO1L(5), GNAS(33), PDIA4(5), PLCG1(9), PLCG2(30), PRKCA(9), SEC61A1(3), SEC61A2(2), TRIM23(2)	15808781	215	107	207	131	142	12	9	24	28	0	0.541	1.000	1.000
245	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(4), CAPN1(5), CAPN2(6), CAPNS1(2), CAPNS2(1), CXCR3(4), EGF(22), EGFR(25), HRAS(3), ITGA1(23), ITGB1(4), MAPK1(4), MAPK3(3), MYL2(9), MYLK(48), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PTK2(7), PXN(2), TLN1(12)	13847150	211	107	202	127	140	13	9	19	30	0	0.585	1.000	1.000
246	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(5), ICAM1(2), ITGA4(45), ITGAL(27), ITGAM(25), ITGB1(4), ITGB2(17), SELE(33), SELL(12), SELP(38)	6733714	208	107	196	82	153	6	5	17	25	2	0.00656	1.000	1.000
247	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(4), CR1(53), CR2(35), FCGR2B(3), HLA-DRA(13), HLA-DRB1(5), ICAM1(2), ITGAL(27), ITGB2(17), PTPRC(36)	6426148	195	106	185	77	127	15	7	15	26	5	0.0243	1.000	1.000
248	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(6), ALDH3A1(10), ALDH3A2(3), ALDH3B1(3), ALDH3B2(8), ALDH9A1(3), AOC2(9), AOC3(9), ASPA(3), CNDP1(10), DDC(16), HAL(14), HARS(8), HDC(25), HNMT(2), MAOA(4), MAOB(13), PRPS1(3), PRPS2(3)	10368931	188	106	178	114	115	13	10	20	29	1	0.467	1.000	1.000
249	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(27), AXIN1(10), CREBBP(24), CTNNB1(17), DVL1(1), EP300(19), FZD1(5), GSK3B(3), HDAC1(2), LDB1(3), LEF1(3), PITX2(6), TRRAP(47), WNT1(2)	14184657	169	106	163	93	91	17	13	24	23	1	0.895	1.000	1.000
250	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	24	GH1(5), GHR(43), GRB2(2), HRAS(3), INSR(23), IRS1(5), JAK2(8), MAPK1(4), MAPK3(3), PIK3CA(10), PIK3R1(3), PLCG1(9), PRKCA(9), PTPN6(5), RAF1(11), RPS6KA1(9), SHC1(2), SLC2A4(8), SOCS1(1), SOS1(10), SRF(3), STAT5A(3), STAT5B(5)	13808726	184	105	174	97	111	16	12	25	19	1	0.514	1.000	1.000
251	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(11), ACACA(23), ACACB(23), ACADM(5), ACAT2(1), ACSS1(2), ACSS2(4), ALDH1A3(2), ALDH1B1(11), ALDH2(6), ALDH3A1(10), ALDH3A2(3), ALDH6A1(4), ALDH7A1(10), ALDH9A1(3), ECHS1(3), EHHADH(6), HADHA(6), HIBCH(1), LDHA(5), LDHAL6A(6), LDHAL6B(6), LDHB(2), LDHC(7), MCEE(2), MLYCD(2), MUT(5), PCCA(5), PCCB(3), SUCLG1(4), SUCLG2(3)	16979753	184	105	177	107	107	14	17	23	23	0	0.768	1.000	1.000
252	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	22	ADCY1(34), AKT1(4), BAX(4), BCL2(3), CSF2RB(24), IGF1(11), IGF1R(15), IL3(3), IL3RA(8), KIT(13), KITLG(10), PIK3CA(10), PIK3R1(3), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5)	9343573	169	104	161	94	105	18	10	16	19	1	0.380	1.000	1.000
253	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	44	AGXT(12), AKR1B10(10), ALAS1(2), ALAS2(6), AMT(1), AOC2(9), AOC3(9), BHMT(8), CBS(7), CHDH(8), CHKA(2), CHKB(3), CTH(1), DAO(12), DLD(3), DMGDH(16), GAMT(4), GARS(6), GATM(6), GCAT(4), GLDC(6), GNMT(1), HSD3B7(5), MAOA(4), MAOB(13), PEMT(2), PHGDH(5), PIPOX(7), PISD(2), PSAT1(4), PSPH(2), RDH11(2), RDH12(2), RDH13(3), RDH14(1), SARDH(20), SARS(5), SARS2(3), SDS(3), SHMT1(2), SHMT2(3), TARS(5), TARS2(7)	17771881	236	104	230	151	160	17	10	15	34	0	0.653	1.000	1.000
254	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	34	AKT1(4), BCL2(3), CBL(10), CFLAR(4), CRKL(2), E2F1(6), FOS(2), GRB2(2), HRAS(3), IL2RA(7), IL2RB(12), IL2RG(3), IRS1(5), JAK1(7), JAK3(11), MAPK1(4), MAPK3(3), MYC(5), NMI(4), PIK3CA(10), PIK3R1(3), PPIA(1), PTPN6(5), RAF1(11), RPS6KB1(4), SHC1(2), SOCS1(1), SOCS3(1), SOS1(10), STAT5A(3), STAT5B(5), SYK(15)	15355772	168	104	163	98	94	20	10	24	19	1	0.844	1.000	1.000
255	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(27), ATP4B(1), ATP5O(5), ATP6AP1(3), ATP6V0A1(13), ATP6V0A4(23), ATP6V0C(1), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(7), ATP6V1H(5), ATP7A(13), ATP7B(23), COX10(7), COX5B(1), COX6A1(1), COX6B1(2), COX6C(1), COX7B(1), COX8A(1), NDUFA10(4), NDUFA4(1), NDUFB2(3), NDUFB5(3), NDUFB6(2), NDUFB7(2), NDUFS1(2), NDUFS2(3), NDUFV1(1), NDUFV2(1), PPA2(4), SDHA(4), SHMT1(2), UQCRC1(4), UQCRFS1(3)	16344614	195	104	193	123	115	12	17	28	21	2	0.895	1.000	1.000
256	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	38	ATF2(6), CDC42(2), DAXX(10), DDIT3(3), ELK1(3), GRB2(2), HMGN1(2), HRAS(3), HSPB1(2), HSPB2(1), MAP2K4(4), MAP2K6(3), MAP3K1(4), MAP3K5(23), MAP3K7(1), MAP3K9(27), MAPK14(5), MAPKAPK2(5), MAPKAPK5(1), MEF2A(3), MEF2B(2), MEF2C(3), MEF2D(6), MKNK1(6), MYC(5), PLA2G4A(16), RIPK1(3), RPS6KA5(7), SHC1(2), STAT1(5), TGFB1(2), TGFB2(3), TGFB3(3), TRAF2(2)	15328745	175	104	170	75	108	14	6	26	21	0	0.238	1.000	1.000
257	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(4), ATF1(5), CDC42(2), CREB5(9), DUSP1(1), DUSP10(9), EEF2K(6), ELK1(3), HSPB1(2), IL1R1(12), MAP2K3(9), MAP2K4(4), MAP2K6(3), MAP3K10(13), MAP3K4(19), MAP3K5(23), MAP3K7(1), MAPK1(4), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MAPKAPK2(5), MAPKAPK5(1), MKNK1(6), MKNK2(4), MYEF2(4), NFKB1(6), NR2C2(1), SRF(3), TRAF6(4)	14189558	175	104	168	100	112	16	3	23	21	0	0.699	1.000	1.000
258	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	ANKHD1(26), EEF1A2(10), EEF1B2(1), EEF1D(2), EEF1G(6), EEF2(3), EEF2K(6), EIF1AX(3), EIF1AY(1), EIF2AK1(4), EIF2AK2(6), EIF2AK3(13), EIF2B1(1), EIF2B2(1), EIF2B3(3), EIF2B4(1), EIF2B5(3), EIF2S1(1), EIF2S3(2), EIF4A1(4), EIF4A2(3), EIF4EBP1(1), EIF4G1(19), EIF4G3(19), EIF5(2), EIF5B(4), ETF1(2), GSPT2(9), PABPC1(5), PABPC3(8), PAIP1(9), SLC35A4(4)	18614061	182	104	181	94	103	22	13	19	25	0	0.726	1.000	1.000
259	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	21	ARHGAP5(13), DIAPH1(10), FYN(8), GSN(6), HRAS(3), ITGA1(23), ITGB1(4), MAPK1(4), MAPK3(3), MYL2(9), MYLK(48), PIK3CA(10), PIK3R1(3), PTK2(7), PXN(2), RAF1(11), ROCK1(6), SHC1(2), SRC(2), TLN1(12)	15559140	186	103	174	95	117	14	7	27	20	1	0.516	1.000	1.000
260	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP1(4), ACP2(3), ACP5(3), ACP6(12), ACPP(9), ACPT(3), ALPI(9), ALPL(11), ALPP(9), ALPPL2(12), CMBL(5), CYP3A4(21), CYP3A43(19), CYP3A5(14), CYP3A7(18), DHRS1(3), DHRS2(8), DHRS3(5), DHRS7(1), DHRSX(6), PON1(14), PON2(3), PON3(7)	7664834	199	103	188	75	146	10	6	12	24	1	5.98e-05	1.000	1.000
261	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(34), CD3D(7), CD3E(2), CD3G(1), CD4(9), CREBBP(24), CSK(1), GNAS(33), GNB1(1), HLA-DRA(13), HLA-DRB1(5), LCK(15), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PTPRC(36), ZAP70(8)	9695157	216	102	206	103	138	22	11	21	23	1	0.116	1.000	1.000
262	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(34), CD3D(7), CD3E(2), CD3G(1), CD4(9), CREBBP(24), CSK(1), GNAS(33), GNB1(1), HLA-DRA(13), HLA-DRB1(5), LCK(15), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PTPRC(36), ZAP70(8)	9695157	216	102	206	103	138	22	11	21	23	1	0.116	1.000	1.000
263	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(2), EXT2(9), EXTL1(4), EXTL3(13), GLCE(8), HS2ST1(1), HS3ST1(11), HS3ST2(8), HS3ST3A1(6), HS3ST3B1(1), HS3ST5(9), HS6ST1(2), HS6ST2(3), HS6ST3(15), NDST1(6), NDST2(2), NDST3(25), NDST4(51)	8709189	176	102	171	96	112	13	8	20	23	0	0.238	1.000	1.000
264	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(27), CAMP(2), CASP3(2), CERK(1), CREB5(9), DAG1(9), EPHB2(36), FOS(2), GNAQ(6), ITPKB(11), JUN(1), MAP2K4(4), MAP2K7(5), MAPK1(4), MAPK10(9), MAPK8(2), MAPK8IP1(7), MAPK8IP2(8), MAPK8IP3(9), MAPK9(4)	12137477	158	102	153	97	103	11	7	17	19	1	0.893	1.000	1.000
265	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	31	A1BG(2), AKT1(4), AKT2(8), AKT3(3), BTK(15), DAPP1(6), GRB2(2), GSK3A(1), GSK3B(3), IARS(10), IGFBP1(3), INPP5D(36), PDK1(2), PIK3CA(10), PPP1R13B(9), RPS6KA1(9), RPS6KA2(6), RPS6KA3(2), RPS6KB1(4), SFN(2), SHC1(2), SOS1(10), SOS2(13), TEC(13), YWHAB(1), YWHAE(2), YWHAG(2), YWHAQ(3)	14749762	183	102	170	80	113	16	10	25	18	1	0.256	1.000	1.000
266	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	30	AKT1(4), AVP(1), CABIN1(17), CALM1(1), CALM2(1), CAMK1(5), CAMK1G(12), HDAC5(6), IGF1(11), IGF1R(15), INSR(23), MAP2K6(3), MAPK14(5), MAPK7(4), MEF2A(3), MEF2B(2), MEF2C(3), MEF2D(6), MYOD1(1), NFATC1(17), NFATC2(12), PIK3CA(10), PIK3R1(3), PPP3CA(5), PPP3CB(4), PPP3CC(2), SYT1(23)	14860672	199	101	187	113	132	16	10	23	17	1	0.518	1.000	1.000
267	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	ADCY1(34), ARHGEF1(1), F2(13), F2R(8), F2RL3(5), GNA12(3), GNA13(1), GNAI1(2), GNAQ(6), GNB1(1), MAP3K7(1), PIK3CA(10), PIK3R1(3), PLCB1(58), PPP1R12B(9), PRKCA(9), PTK2B(12), ROCK1(6)	11017213	182	101	171	88	120	14	8	23	15	2	0.192	1.000	1.000
268	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	17	CBL(10), EGF(22), EGFR(25), GRB2(2), HRAS(3), MAPK1(4), MAPK3(3), PTPRB(84), RAF1(11), RASA1(5), SHC1(2), SOS1(10), SPRY1(10), SPRY2(3), SPRY3(12), SPRY4(1), SRC(2)	10311862	209	101	195	97	139	20	6	23	21	0	0.386	1.000	1.000
269	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(6), BAX(4), BCL2(3), BCL2A1(2), BCL2L2(3), CASP1(4), CASP10(6), CASP2(1), CASP3(2), CASP4(2), CASP7(4), CASP8(9), CASP9(2), CD40(4), CD40LG(1), CRADD(2), CYCS(1), DAXX(10), DFFA(2), DFFB(2), FAS(5), FASLG(15), IKBKE(9), LTA(5), MCL1(3), NFKB1(6), NFKBIA(2), NGFR(8), NR3C1(7), NTRK1(16), PTPN13(17), RIPK1(3), TFG(1), TNF(1), TNFRSF1A(4), TNFRSF1B(4), TRAF1(6), TRAF2(2), TRAF3(5), TRAF6(4)	18464851	193	100	190	125	119	18	7	24	24	1	0.977	1.000	1.000
270	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(9), ABAT(11), ACADS(5), ACAT2(1), ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(6), ALDH3A1(10), ALDH3A2(3), ALDH5A1(10), ALDH9A1(3), ECHS1(3), EHHADH(6), GAD1(14), GAD2(9), HADHA(6), HMGCL(4), L2HGDH(4), OXCT1(4), PDHA1(4), PDHA2(20), PDHB(1), SDS(3)	11044883	172	100	164	79	108	16	7	20	21	0	0.0724	1.000	1.000
271	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	22	BCAR1(5), CRK(3), CXCL12(2), CXCR4(3), GNAI1(2), GNAQ(6), GNB1(1), HRAS(3), MAPK1(4), MAPK3(3), NFKB1(6), PIK3C2G(56), PIK3CA(10), PIK3R1(3), PLCG1(9), PRKCA(9), PTK2(7), PTK2B(12), PXN(2), RAF1(11), RELA(4)	11370108	161	100	146	92	106	12	6	23	13	1	0.759	1.000	1.000
272	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(2), CDC7(3), CDK2(1), CDT1(2), DIAPH2(8), MCM10(7), MCM2(11), MCM3(9), MCM4(8), MCM5(5), MCM6(5), MCM7(1), NACA(44), PCNA(2), POLA2(9), POLD1(7), POLD2(2), POLD3(7), POLE(16), POLE2(2), PRIM1(3), RFC1(5), RFC2(4), RFC3(1), RPA1(3), RPA2(2), RPA4(2), UBB(1), UBC(6)	21570075	178	100	175	110	121	12	6	25	14	0	0.878	1.000	1.000
273	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ACY1(2), AGMAT(4), ALDH18A1(8), ALDH1A3(2), ALDH1B1(11), ALDH2(6), ALDH3A1(10), ALDH3A2(3), ALDH7A1(10), ALDH9A1(3), AOC2(9), AOC3(9), ARG1(2), ARG2(2), ASL(7), ASS1(8), CPS1(29), GATM(6), MAOA(4), MAOB(13), NAGS(1), ODC1(3), OTC(4), SMS(5), SRM(1)	12448901	162	100	157	95	88	15	10	22	27	0	0.600	1.000	1.000
274	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(13), BCAT2(1), COASY(5), DPYD(73), DPYS(28), ENPP1(13), ENPP3(14), ILVBL(5), PANK1(3), PANK2(5), PANK3(4), PANK4(6), PPCS(3), UPB1(11), VNN1(7)	7364067	191	100	169	55	140	11	3	21	16	0	8.53e-06	1.000	1.000
275	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(15), ABCC2(12), ABCG2(5), BCHE(7), CES1(21), CES2(4), CYP3A4(21), CYP3A5(14), UGT1A1(12), UGT1A10(18), UGT1A3(14), UGT1A4(10), UGT1A5(10), UGT1A6(15), UGT1A7(12), UGT1A9(16)	9767425	206	100	187	88	139	17	11	17	20	2	0.00104	1.000	1.000
276	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(11), ACACA(23), ACADL(5), ACADM(5), ACADSB(6), ACAT2(1), ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(6), ALDH3A1(10), ALDH3A2(3), ALDH6A1(4), ALDH9A1(3), ECHS1(3), EHHADH(6), HADHA(6), LDHA(5), LDHB(2), LDHC(7), MCEE(2), MLYCD(2), MUT(5), PCCA(5), PCCB(3), SDS(3), SUCLG1(4), SUCLG2(3)	14168861	169	100	162	83	105	12	12	23	17	0	0.405	1.000	1.000
277	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	31	AGT(8), AGTR1(10), ATF2(6), CALM1(1), CALM2(1), EGFR(25), ELK1(3), GNAQ(6), GRB2(2), HRAS(3), JUN(1), MAP2K2(5), MAP2K4(4), MAP3K1(4), MAPK1(4), MAPK3(3), MAPK8(2), MEF2A(3), MEF2B(2), MEF2C(3), MEF2D(6), PAK1(4), PRKCA(9), PTK2(7), PTK2B(12), RAF1(11), SHC1(2), SOS1(10), SRC(2), SYT1(23)	13740076	182	99	172	116	113	17	10	24	17	1	0.977	1.000	1.000
278	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(8), F2(13), F2R(8), F3(2), F5(39), F7(7), FGA(41), FGB(10), FGG(10), PROC(11), PROS1(17), SERPINC1(7), TFPI(7)	6998214	180	98	166	74	121	20	8	19	11	1	0.0979	1.000	1.000
279	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(2), AKR1B10(10), ALDOA(1), ALDOB(14), ALDOC(4), FBP1(3), FBP2(2), FPGT(3), FUK(5), GMDS(5), GMPPA(1), GMPPB(4), HK1(3), HK2(15), HK3(15), HSD3B7(5), KHK(2), LHPP(1), MPI(1), MTMR1(6), MTMR2(3), MTMR6(2), PFKFB1(4), PFKFB2(5), PFKFB3(4), PFKFB4(7), PFKL(3), PFKP(2), PGM2(7), PMM1(4), PMM2(3), RDH11(2), RDH12(2), RDH13(3), RDH14(1), SORD(2), TPI1(1), TSTA3(4)	15743248	161	98	157	117	102	14	12	17	16	0	0.859	1.000	1.000
280	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOA(1), ALDOB(14), ALDOC(4), FBP1(3), FBP2(2), GOT1(6), GOT2(6), GPT(4), GPT2(2), MDH1(3), MDH2(4), ME1(22), ME3(8), PGK1(3), PGK2(36), PKLR(14), TKT(6), TKTL1(3), TKTL2(28), TPI1(1)	8638255	170	98	157	95	124	17	5	13	10	1	0.0732	1.000	1.000
281	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	BCL2(3), CREBBP(24), EP300(19), FYN(8), IL2RG(3), IL7(5), IL7R(37), JAK1(7), JAK3(11), LCK(15), NMI(4), PIK3CA(10), PIK3R1(3), PTK2B(12), STAT5A(3), STAT5B(5)	11900062	169	98	164	83	101	19	8	23	16	2	0.428	1.000	1.000
282	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	25	ADCY1(34), AKT1(4), CAMK2A(6), CAMK2B(6), CAMK2D(6), CAMK2G(5), GNAS(33), GRB2(2), HRAS(3), MAPK1(4), MAPK14(5), MAPK3(3), PIK3CA(10), PIK3R1(3), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCA(9), RPS6KA1(9), RPS6KA5(7), SOS1(10)	12178266	186	97	179	107	118	19	9	19	20	1	0.792	1.000	1.000
283	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(1), F13A1(26), F2(13), F2R(8), FGA(41), FGB(10), FGG(10), PLAT(5), PLG(36), SERPINB2(20), SERPINE1(6)	5693092	176	97	167	65	124	11	10	18	12	1	0.0223	1.000	1.000
284	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	21	ATM(16), ATR(22), BRCA1(16), CDC25A(8), CDC25B(4), CDC25C(5), CDC34(4), CDKN1A(3), CHEK1(2), CHEK2(2), EP300(19), MDM2(4), MYT1(21), PRKDC(22), RPS6KA1(9), WEE1(2), YWHAQ(3)	17533576	162	97	159	76	98	14	8	29	13	0	0.674	1.000	1.000
285	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(2), IFNA1(1), IFNB1(6), IKBKB(4), IL1A(5), IL1B(8), IL1R1(12), IL1RAP(3), IL1RN(8), IL6(2), IRAK1(5), IRAK2(15), IRAK3(11), JUN(1), MAP2K3(9), MAP2K6(3), MAP3K1(4), MAP3K7(1), MAPK14(5), MAPK8(2), MYD88(1), NFKB1(6), NFKBIA(2), RELA(4), TGFB1(2), TGFB2(3), TGFB3(3), TNF(1), TOLLIP(1), TRAF6(4)	12575253	134	97	129	75	86	12	4	13	19	0	0.542	1.000	1.000
286	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(17), ADH1B(30), ADH4(12), ADH5(3), ADH6(14), ADH7(16), ADHFE1(6), ALDH1A3(2), ALDH1B1(11), ALDH2(6), ALDH3A1(10), ALDH3A2(3), ALDH7A1(10), ALDH9A1(3)	5638748	143	96	124	50	102	9	11	11	10	0	0.000650	1.000	1.000
287	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(13), COASY(5), DPYD(73), DPYS(28), ENPP1(13), ENPP3(14), PANK1(3), PANK2(5), PANK3(4), PANK4(6), PPCS(3), UPB1(11)	5933233	178	96	156	50	128	11	3	21	15	0	5.83e-05	1.000	1.000
288	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(6), AKT1(4), AKT2(8), AKT3(3), DAG1(9), GNAQ(6), ITPKB(11), ITPR1(36), ITPR2(20), ITPR3(12), NFKB1(6), NFKB2(5), NFKBIA(2), NFKBIB(1), NFKBIL1(2), PDK1(2), PHKA2(9), PIK3CB(10), PITX2(6), PLD1(14), PLD2(8), PLD3(1), VN1R1(1)	19078956	182	96	174	124	102	17	13	28	22	0	0.889	1.000	1.000
289	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	40	APAF1(6), BAK1(2), BAX(4), BCL2(3), BIRC2(6), BIRC3(7), CASP2(1), CASP3(2), CASP7(4), CASP8(9), CASP9(2), CYCS(1), FAS(5), FASLG(15), GZMB(3), JUN(1), MAP2K4(4), MAP3K1(4), MAPK10(9), MCL1(3), MDM2(4), MYC(5), NFKB1(6), NFKBIA(2), PARP1(7), PRF1(14), RELA(4), RIPK1(3), TNF(1), TNFRSF1A(4), TNFRSF1B(4), TNFSF10(9), TRAF1(6), TRAF2(2)	15536074	162	95	160	79	93	18	10	19	22	0	0.388	1.000	1.000
290	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	AANAT(1), ACHE(9), CHAT(20), COMT(4), DBH(16), DDC(16), GAD1(14), GAD2(9), HDC(25), MAOA(4), PAH(12), PNMT(4), SLC18A3(2), TH(11), TPH1(12)	6036350	159	95	150	97	113	14	6	6	19	1	0.197	1.000	1.000
291	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	ARNTL(7), AZIN1(1), BTG1(5), CBX3(2), CLOCK(4), CRY1(7), CRY2(7), EIF4G2(6), ETV6(10), GFRA1(8), GSTM3(4), GSTP1(3), HERPUD1(2), HSPA8(5), IDI1(1), KLF9(3), MYF6(15), NCKAP1(5), NCOA4(4), NR1D2(11), PER1(8), PER2(12), PIGF(2), PPP1R3C(4), PPP2CB(2), PSMA4(4), PURA(2), SF3A3(7), SUMO3(2), TOB1(3), TUBB3(4), UCP3(6), UGP2(1), VAPA(2), ZFR(10)	15560924	179	95	176	82	92	18	16	32	21	0	0.592	1.000	1.000
292	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	21	AKT1(4), EIF4A1(4), EIF4A2(3), EIF4EBP1(1), EIF4G1(19), EIF4G2(6), EIF4G3(19), GHR(43), IRS1(5), MAPK1(4), MAPK14(5), MAPK3(3), MKNK1(6), PABPC1(5), PDK2(4), PDPK1(5), PIK3CA(10), PIK3R1(3), PRKCA(9), RPS6KB1(4)	11724819	162	95	152	62	98	19	8	16	20	1	0.0690	1.000	1.000
293	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSB(3), ARSD(3), ARSE(5), GAL3ST1(11), GALC(3), GBA(7), GLA(2), GLB1(10), LCT(54), NEU1(6), NEU2(19), NEU3(4), NEU4(16), PPAP2B(11), PPAP2C(8), SMPD1(2), SMPD2(2), SPTLC1(2), SPTLC2(8), UGCG(1)	10226157	177	95	172	111	119	15	3	22	18	0	0.827	1.000	1.000
294	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(11), ALDH4A1(6), ALDH5A1(10), CAD(18), CPS1(29), EARS2(2), EPRS(13), GAD1(14), GAD2(9), GCLC(5), GCLM(2), GFPT1(6), GFPT2(9), GLS(2), GLS2(3), GLUD1(2), GLUD2(4), GLUL(1), GMPS(6), GOT1(6), GOT2(6), GPT(4), GPT2(2), GSR(2), GSS(9), NADSYN1(4), NAGK(1), QARS(6)	16849083	192	95	185	108	111	23	11	27	19	1	0.594	1.000	1.000
295	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(18), ANAPC10(1), ANAPC2(7), ANAPC4(6), ANAPC5(5), ANAPC7(6), BTRC(4), CDC20(1), CDC23(4), CDC27(14), CUL1(3), CUL2(4), CUL3(5), FBXW11(6), FBXW7(11), FZR1(8), ITCH(9), SKP2(2), SMURF1(2), SMURF2(9), TCEB1(1), TCEB2(1), UBA1(3), UBE2D1(1), UBE2D3(3), UBE2E1(1), UBE2E2(4), UBE2E3(1), VHL(4), WWP1(7), WWP2(9)	16992013	160	95	155	75	102	8	8	18	23	1	0.700	1.000	1.000
296	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(5), AASDH(5), AASDHPPT(3), AASS(3), ACAT2(1), ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(6), ALDH3A1(10), ALDH3A2(3), ALDH9A1(3), ATP6V0C(1), BBOX1(7), DLST(1), DOT1L(12), ECHS1(3), EHHADH(6), EHMT1(11), EHMT2(9), GCDH(6), HADHA(6), PLOD1(6), PLOD2(7), PLOD3(5), SDS(3), SHMT1(2), SHMT2(3), TMLHE(2)	15709863	165	95	159	97	105	17	6	21	15	1	0.603	1.000	1.000
297	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(7), BAIAP2(8), CASP1(4), CASP3(2), CASP7(4), CASP8(9), GAPDH(2), INSR(23), ITCH(9), MAGI1(38), MAGI2(24), RERE(25), WWP1(7), WWP2(9)	10275967	171	93	166	78	114	12	6	17	21	1	0.310	1.000	1.000
298	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(6), ESR2(10), PDE1A(44), PDE1B(15), PLCB1(58), PLCB2(12), PRL(3), TRH(4), VIP(5)	4695304	157	93	137	66	120	5	2	14	16	0	0.00410	1.000	1.000
299	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	ARHGDIB(4), CASP10(6), CASP3(2), CASP7(4), CASP8(9), CFLAR(4), DAXX(10), DFFA(2), DFFB(2), FAF1(9), JUN(1), LMNA(5), LMNB1(2), LMNB2(4), MAP2K4(4), MAP3K1(4), MAP3K7(1), MAPK8(2), PAK1(4), PAK2(9), PRKDC(22), PTPN13(17), RB1(10), RIPK2(3), SPTAN1(10)	17418966	150	92	149	85	68	13	12	32	23	2	0.962	1.000	1.000
300	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	32	DUSP1(1), GORASP1(1), MAP2K4(4), MAP2K7(5), MAPK1(4), MAPK10(9), MAPK11(1), MAPK12(1), MAPK13(5), MAPK14(5), MAPK3(3), MAPK8(2), MAPK8IP1(7), MAPK8IP2(8), MAPK8IP3(9), MAPK9(4), MAPKAPK5(1), NFKB1(6), NFKB2(5), NFKBIA(2), NFKBIB(1), NFKBIL1(2), PIK3CA(10), PIK3CD(8), PIK3R1(3), SYT1(23), TRAF2(2), TRAF3(5), TRAF5(8), TRAF6(4)	14273666	149	92	143	103	100	9	7	19	13	1	0.910	1.000	1.000
301	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(34), ADRB2(4), CFTR(62), GNAS(33), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), SLC9A3R1(2)	5542558	162	91	150	90	108	14	7	14	18	1	0.448	1.000	1.000
302	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	26	ACLY(12), ACO1(8), ACO2(5), CLYBL(5), CS(2), DLD(3), DLST(1), FH(3), IDH2(2), IDH3A(3), IDH3B(2), IDH3G(2), MDH1(3), MDH2(4), OGDH(9), OGDHL(44), PC(14), PCK1(25), PCK2(6), SDHA(4), SDHC(3), SDHD(1), SUCLG1(4), SUCLG2(3)	12416508	168	91	162	92	109	6	7	25	21	0	0.349	1.000	1.000
303	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(13), ARHGEF1(1), GNA12(3), GNA13(1), GNAQ(6), GNB1(1), MYL2(9), MYLK(48), PLCB1(58), PPP1R12B(9), PRKCA(9), ROCK1(6)	8853425	164	91	146	72	119	2	7	19	17	0	0.109	1.000	1.000
304	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(34), ADRB2(4), GNAS(33), PLCE1(56), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5)	6249260	154	91	147	79	100	17	10	14	13	0	0.339	1.000	1.000
305	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5(6), CDK5R1(1), DAB1(48), FYN(8), LRP8(3), RELN(90), VLDLR(5)	5963173	161	91	154	89	114	9	3	16	18	1	0.888	1.000	1.000
306	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	25	CSNK2A1(2), EGF(22), EGFR(25), ELK1(3), FOS(2), GRB2(2), HRAS(3), JAK1(7), JUN(1), MAP2K4(4), MAP3K1(4), MAPK3(3), MAPK8(2), PIK3CA(10), PIK3R1(3), PLCG1(9), PRKCA(9), RAF1(11), RASA1(5), SHC1(2), SOS1(10), SRF(3), STAT1(5), STAT3(11), STAT5A(3)	15637529	161	90	158	91	88	17	8	29	18	1	0.940	1.000	1.000
307	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(3), GALNS(5), GLB1(10), GNS(2), GUSB(5), HEXA(5), HEXB(4), HGSNAT(5), HPSE(10), HPSE2(5), HYAL1(2), HYAL2(1), IDS(9), IDUA(6), LCT(54), NAGLU(4), SPAM1(28)	8678408	158	90	154	96	114	10	3	15	16	0	0.690	1.000	1.000
308	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCR1(10), CCR2(17), CCR3(11), CCR4(9), CCR5(10), CCR7(4), CD28(2), CD4(9), CSF2(2), CXCR3(4), CXCR4(3), IFNG(4), IFNGR1(3), IFNGR2(4), IL12A(4), IL12B(3), IL12RB1(15), IL12RB2(3), IL18R1(21), IL2(4), IL4(1), IL4R(18), IL5(4), TGFB1(2), TGFB2(3), TGFB3(3)	8508318	173	90	162	95	126	12	2	13	20	0	0.0378	1.000	1.000
309	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(6), BCL2(3), BIRC2(6), BIRC3(7), CASP10(6), CASP3(2), CASP7(4), CASP8(9), CASP9(2), CFLAR(4), CHUK(2), CYCS(1), DFFA(2), DFFB(2), GAS2(14), LMNA(5), NFKB1(6), NFKBIA(2), RELA(4), RIPK1(3), SPTAN1(10), TNFRSF10A(7), TNFRSF10B(5), TNFRSF25(6), TNFSF10(9), TNFSF12(2), TRAF2(2)	14242218	131	89	129	80	72	17	9	20	13	0	0.879	1.000	1.000
310	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(5), ICAM1(2), ITGA4(45), ITGAL(27), ITGB1(4), ITGB2(17), SELE(33), SELL(12)	5121911	145	89	139	56	105	5	4	11	18	2	0.0283	1.000	1.000
311	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	26	BCAR1(5), CALM1(1), CALM2(1), CRKL(2), GNAQ(6), GRB2(2), HRAS(3), JUN(1), MAP2K2(5), MAP2K3(9), MAP2K4(4), MAP3K1(4), MAPK1(4), MAPK14(5), MAPK3(3), MAPK8(2), PAK1(4), PLCG1(9), PRKCA(9), PTK2B(12), RAF1(11), SHC1(2), SOS1(10), SRC(2), SYT1(23)	11620131	139	89	131	86	80	15	8	21	15	0	0.933	1.000	1.000
312	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	27	AKT1(4), AKT2(8), AKT3(3), BCL2(3), GRB2(2), GSK3A(1), GSK3B(3), IL4R(18), IRS1(5), IRS2(3), JAK1(7), JAK3(11), MAP4K1(12), MAPK1(4), MAPK3(3), PDK1(2), PIK3CA(10), PIK3CD(8), PIK3R1(3), PPP1R13B(9), RAF1(11), SHC1(2), SOCS1(1), SOS1(10), SOS2(13), STAT6(9)	15586079	165	89	163	82	91	24	6	26	17	1	0.481	1.000	1.000
313	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(11), ALDH4A1(6), ALDH5A1(10), CAD(18), CPS1(29), EPRS(13), GAD1(14), GAD2(9), GCLC(5), GCLM(2), GFPT1(6), GLS(2), GLS2(3), GLUD1(2), GLUL(1), GMPS(6), GOT1(6), GOT2(6), GPT(4), GPT2(2), GSS(9), NADSYN1(4), QARS(6)	14165629	174	88	167	91	100	19	10	26	18	1	0.485	1.000	1.000
314	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(3), ACAD9(2), ADH1A(17), ADH1B(30), ADH4(12), ADH5(3), ADH6(14), ADH7(16), ADHFE1(6), DHRS1(3), DHRS2(8), DHRS3(5), DHRS7(1), DHRSX(6), ESCO1(2), ESCO2(4), NAT6(5), PNPLA3(3), SH3GLB1(2)	10680233	142	88	125	59	105	9	9	12	7	0	0.103	1.000	1.000
315	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(4), ADCY1(34), CAP1(1), CDC25C(5), GNAI1(2), GNAS(33), GNB1(1), HRAS(3), MAPK1(4), MAPK3(3), MYT1(21), PIN1(1), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), RPS6KA1(9), SRC(2)	8761289	150	88	144	95	101	16	7	13	13	0	0.706	1.000	1.000
316	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(4), GALNT10(7), GALNT2(7), GALNT3(4), GALNT4(5), GALNT6(16), GALNT7(4), GALNT8(28), GALNT9(7), GCNT1(6), ST3GAL1(8), ST3GAL2(1), ST3GAL4(1), WBSCR17(46)	6180311	144	88	133	65	103	9	4	13	15	0	0.0767	1.000	1.000
317	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	25	CSNK2A1(2), ELK1(3), FOS(2), GRB2(2), HRAS(3), JAK1(7), JUN(1), MAP2K4(4), MAP3K1(4), MAPK3(3), MAPK8(2), PDGFA(1), PDGFRA(32), PIK3CA(10), PIK3R1(3), PLCG1(9), PRKCA(9), RAF1(11), RASA1(5), SHC1(2), SOS1(10), SRF(3), STAT1(5), STAT3(11), STAT5A(3)	14537831	147	88	144	73	79	16	7	30	14	1	0.705	1.000	1.000
318	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	14	AKT1(4), BCL2(3), EGFR(25), IGF1R(15), MYC(5), POLR2A(13), PPP2CA(1), PRKCA(9), RB1(10), TEP1(36), TERF1(2), TERT(9), TNKS(10), XRCC5(2)	11652428	144	88	140	87	84	15	9	16	18	2	0.765	1.000	1.000
319	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM1(1), CALM2(1), CHUK(2), EGR2(5), EGR3(4), GNAQ(6), MAP3K1(4), MYC(5), NFATC1(17), NFATC2(12), NFKB1(6), NFKBIA(2), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), RELA(4), SYT1(23), VIP(5), VIPR2(7)	11897942	151	88	144	93	97	11	8	17	18	0	0.888	1.000	1.000
320	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(4), EPHA4(22), EPHB1(31), FYN(8), ITGA1(23), ITGB1(4), L1CAM(11), LYN(11), RAP1B(1), SELP(38)	6728695	153	87	141	77	108	7	4	17	16	1	0.297	1.000	1.000
321	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(27), AXIN1(10), BTRC(4), CCND1(2), CREBBP(24), CSNK1A1(5), CSNK1D(3), CSNK2A1(2), CTNNB1(17), DVL1(1), FZD1(5), GSK3B(3), HDAC1(2), MAP3K7(1), MYC(5), NLK(5), PPARD(3), PPP2CA(1), TLE1(4), WIF1(7), WNT1(2)	12450768	133	87	130	73	66	11	12	21	23	0	0.926	1.000	1.000
322	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	20	ATM(16), ATR(22), BRCA1(16), BRCA2(21), CHEK1(2), CHEK2(2), FANCA(8), FANCC(2), FANCD2(14), FANCE(4), FANCG(7), HUS1(2), MRE11A(5), RAD1(3), RAD17(6), RAD50(6), RAD9A(6), TREX1(1)	18449843	143	86	140	74	93	7	5	17	21	0	0.906	1.000	1.000
323	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(10), CSF1R(13), EGF(22), EGFR(25), GRB2(2), MET(23), PDGFRA(32), PRKCA(9), SH3GLB1(2), SH3GLB2(1), SH3KBP1(6), SRC(2)	8308320	147	86	145	90	96	9	5	18	19	0	0.885	1.000	1.000
324	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(5), FUCA1(3), GLB1(10), HEXA(5), HEXB(4), LCT(54), MAN2B1(9), MAN2B2(10), MAN2C1(4), MANBA(7), NEU1(6), NEU2(19), NEU3(4), NEU4(16)	8660488	156	86	154	85	111	16	2	14	12	1	0.314	1.000	1.000
325	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(12), CSF1R(13), DDX20(11), E2F1(6), E2F4(3), ETS1(4), ETS2(8), ETV3(3), FOS(2), HDAC2(2), HDAC5(6), HRAS(3), JUN(1), NCOR2(28), RBL1(14), RBL2(6), SIN3A(11), SIN3B(8)	11072204	141	85	140	81	92	7	3	27	12	0	0.635	1.000	1.000
326	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(1), AGPAT2(3), AGPAT3(5), AGPAT4(6), AGPAT6(3), AGPS(5), CHPT1(1), ENPP2(1), ENPP6(14), PAFAH1B1(6), PAFAH1B2(2), PAFAH1B3(1), PAFAH2(2), PLA2G12B(3), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(19), PLA2G4A(16), PLA2G5(2), PLA2G6(13), PLD1(14), PLD2(8), PPAP2B(11), PPAP2C(8)	9935487	163	85	157	86	102	13	5	22	19	2	0.355	1.000	1.000
327	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(3), POLA2(9), POLB(1), POLD1(7), POLD2(2), POLD3(7), POLE(16), POLE2(2), POLG(8), POLG2(7), POLH(4), POLI(2), POLK(7), POLL(10), POLM(2), POLQ(26), PRIM1(3), PRIM2(6), REV1(3), REV3L(18)	17244921	143	85	142	70	78	10	11	26	18	0	0.730	1.000	1.000
328	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(39), ABCB11(49), ABCB4(21), ABCC1(15), ABCC3(30), GSTP1(3)	6071115	157	85	145	75	104	17	5	12	18	1	0.00267	1.000	1.000
329	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(11), AGT(8), AGTR2(10), EDN1(9), EDNRA(11), EDNRB(7), EGF(22), EGFR(25), FOS(2), HRAS(3), JUN(1), MYC(5), NFKB1(6), PLCG1(9), PRKCA(9), RELA(4)	8756081	142	84	139	77	97	10	8	12	14	1	0.357	1.000	1.000
330	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5(6), CDK5R1(1), CSNK1D(3), DRD1(9), DRD2(16), GRM1(13), PLCB1(58), PPP1CA(3), PPP1R1B(2), PPP2CA(1), PPP3CA(5), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5)	6801342	144	84	135	94	106	4	6	13	14	1	0.686	1.000	1.000
331	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	22	ABL1(15), ATM(16), ATR(22), CCNA1(16), CCND1(2), CCNE1(4), CDC25A(8), CDK2(1), CDK6(2), CDKN1A(3), CDKN1B(1), DHFR(1), E2F1(6), GSK3B(3), HDAC1(2), RB1(10), SKP2(2), TFDP1(2), TGFB1(2), TGFB2(3), TGFB3(3)	11971847	124	84	123	60	71	8	10	15	18	2	0.565	1.000	1.000
332	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM1(1), CALM2(1), CAMK1(5), CAMK1G(12), CAMK2A(6), CAMK2B(6), CAMK2D(6), CAMK2G(5), CAMK4(17), ESRRA(3), HDAC5(6), MEF2A(3), MEF2B(2), MEF2C(3), MEF2D(6), PPARA(8), PPP3CA(5), PPP3CB(4), PPP3CC(2), SLC2A4(8), SYT1(23)	8558172	132	84	125	80	93	8	5	12	14	0	0.529	1.000	1.000
333	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	14	CUZD1(20), FOS(2), HRAS(3), JUN(1), MAPK1(4), MAPK3(3), MYC(5), NFKB1(6), NFKBIA(2), PLCB1(58), PRKCA(9), RAF1(11), RELA(4), TNF(1)	6311573	129	83	117	56	89	10	7	12	11	0	0.0398	1.000	1.000
334	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(34), GNAS(33), GNB1(1), PPP2CA(1), PRKAA1(1), PRKAA2(32), PRKAB1(2), PRKAB2(2), PRKACB(4), PRKACG(10), PRKAG1(3), PRKAG2(8), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5)	6526432	144	83	137	66	97	14	8	9	16	0	0.172	1.000	1.000
335	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOA(1), ALDOB(14), ALDOC(4), DERA(2), FBP1(3), FBP2(2), G6PD(4), GPI(3), H6PD(7), PFKL(3), PFKP(2), PGD(9), PGLS(3), PGM1(6), PGM3(1), PRPS1(3), PRPS1L1(13), PRPS2(3), RBKS(4), TALDO1(3), TKT(6), TKTL1(3), TKTL2(28)	10337668	127	83	119	91	82	11	5	12	17	0	0.732	1.000	1.000
336	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	35	ANPEP(25), G6PD(4), GCLC(5), GCLM(2), GGT1(8), GPX3(2), GPX5(19), GPX6(19), GSR(2), GSS(9), GSTA1(7), GSTA2(3), GSTA3(1), GSTA4(1), GSTA5(3), GSTK1(4), GSTM1(2), GSTM2(2), GSTM3(4), GSTM4(2), GSTM5(6), GSTO2(1), GSTP1(3), GSTT1(1), GSTZ1(1), IDH2(2), MGST1(2), MGST2(2), MGST3(2), OPLAH(13), TXNDC12(1)	8975346	158	83	148	88	103	10	7	23	15	0	0.125	1.000	1.000
337	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(4), CHIA(10), CHIT1(12), CMAS(2), CTBS(6), CYB5R1(1), CYB5R3(2), GFPT1(6), GFPT2(9), GNE(3), GNPDA1(1), GNPDA2(1), HEXA(5), HEXB(4), HK1(3), HK2(15), HK3(15), LHPP(1), MTMR1(6), MTMR2(3), MTMR6(2), NAGK(1), NANS(1), NPL(2), PGM3(1), RENBP(3), UAP1(2)	12220567	121	83	119	81	74	10	6	19	12	0	0.947	1.000	1.000
338	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(10), GABRA1(20), GABRA2(19), GABRA3(24), GABRA4(15), GABRA5(4), GABRA6(29), GPHN(8), SRC(2), UBQLN1(5)	5015372	136	82	119	76	99	6	5	14	10	2	0.494	1.000	1.000
339	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(2), CREBBP(24), DUSP1(1), EP300(19), IKBKB(4), IL1B(8), MAP2K3(9), MAP2K6(3), MAP3K7(1), MAPK11(1), MAPK14(5), MYD88(1), NFKB1(6), NFKBIA(2), NR3C1(7), RELA(4), TGFBR2(9), TLR2(15), TNF(1)	12666350	122	82	121	74	73	18	5	15	11	0	0.920	1.000	1.000
340	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CCNH(1), CDK7(2), ERCC3(6), GTF2A2(1), GTF2B(5), GTF2E1(3), GTF2E2(6), GTF2F2(2), GTF2H1(3), GTF2H4(2), ILK(2), MNAT1(2), POLR1A(13), POLR1B(8), POLR2A(13), POLR2B(14), POLR2C(1), POLR2E(1), POLR2F(2), POLR2H(2), POLR2J(2), POLR3B(15), POLR3D(1), POLR3E(5), POLR3H(1), POLR3K(1), TAF13(1), TAF6(3), TAF7(3), TAF9(2), TBP(4)	14984109	127	82	123	63	75	11	9	21	11	0	0.567	1.000	1.000
341	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	20	AARS(4), ABAT(11), ADSL(6), ADSS(2), AGXT(12), ASL(7), ASNS(9), ASPA(3), CAD(18), CRAT(5), DARS(4), DDO(9), GAD1(14), GAD2(9), GOT1(6), GOT2(6), GPT(4), GPT2(2), NARS(2), PC(14)	10723068	147	81	143	93	98	16	8	12	13	0	0.549	1.000	1.000
342	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	ADRB2(4), AKT1(4), ANXA1(7), CALM1(1), CALM2(1), GNAS(33), GNB1(1), NFKB1(6), NOS3(20), NPPA(5), NR3C1(7), PIK3CA(10), PIK3R1(3), RELA(4), SYT1(23)	7604428	129	81	120	58	88	12	5	18	5	1	0.300	1.000	1.000
343	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(6), DYRK1B(2), GLI2(44), GLI3(19), GSK3B(3), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), SHH(3), SMO(10), SUFU(2)	7088275	116	81	113	78	78	11	5	12	10	0	0.862	1.000	1.000
344	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	ARHGDIB(4), BAG4(3), CASP2(1), CASP3(2), CASP8(9), CRADD(2), DFFA(2), DFFB(2), JUN(1), LMNA(5), LMNB1(2), LMNB2(4), MADD(15), MAP2K4(4), MAP3K1(4), MAP3K7(1), MAPK8(2), PAK1(4), PAK2(9), PRKDC(22), RB1(10), RIPK1(3), SPTAN1(10), TNF(1), TNFRSF1A(4), TRAF2(2)	16569459	128	81	127	72	61	10	12	22	19	4	0.849	1.000	1.000
345	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(1), ASNS(9), ASRGL1(6), CA1(9), CA12(3), CA13(5), CA2(12), CA3(6), CA4(3), CA5A(3), CA5B(1), CA6(4), CA7(2), CA8(6), CA9(8), CPS1(29), CTH(1), GLS(2), GLS2(3), GLUD1(2), GLUD2(4), GLUL(1), HAL(14)	8995302	134	80	129	68	93	9	5	16	11	0	0.383	1.000	1.000
346	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	20	AKT1(4), EIF4A1(4), EIF4A2(3), EIF4B(6), EIF4EBP1(1), EIF4G1(19), EIF4G2(6), EIF4G3(19), MKNK1(6), PDK2(4), PDPK1(5), PIK3CA(10), PIK3R1(3), PPP2CA(1), RPS6(1), RPS6KB1(4), TSC1(9), TSC2(14)	11458530	119	80	115	52	64	14	7	15	17	2	0.357	1.000	1.000
347	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(36), AGT(8), AGTR1(10), AGTR2(10), BDKRB2(10), KNG1(14), NOS3(20), REN(12)	4227401	120	79	115	72	78	8	6	10	16	2	0.150	1.000	1.000
348	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(2), ALDOA(1), ALDOB(14), ALDOC(4), FBP1(3), FBP2(2), FPGT(3), GCK(16), GMDS(5), GMPPA(1), GMPPB(4), HK1(3), HK2(15), HK3(15), KHK(2), MPI(1), PFKFB1(4), PFKFB3(4), PFKFB4(7), PFKP(2), PMM1(4), PMM2(3), SORD(2), TPI1(1)	10151370	118	79	113	89	79	12	6	9	12	0	0.742	1.000	1.000
349	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(13), BCAT2(1), IARS(10), IARS2(18), ILVBL(5), LARS(13), LARS2(5), PDHA1(4), PDHA2(20), PDHB(1), VARS(16), VARS2(7)	8037888	113	79	104	54	75	12	3	11	12	0	0.362	1.000	1.000
350	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(2), GPLD1(27), PGAP1(9), PIGA(2), PIGB(3), PIGC(3), PIGF(2), PIGG(9), PIGH(2), PIGK(7), PIGL(3), PIGM(2), PIGN(3), PIGO(15), PIGQ(9), PIGS(1), PIGT(1), PIGU(7), PIGV(9), PIGW(1), PIGX(2), PIGZ(4)	10175297	123	79	120	57	69	9	7	26	12	0	0.135	1.000	1.000
351	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CCR5(10), CD3D(7), CD3E(2), CD3G(1), CXCR3(4), ETV5(7), IFNG(4), IL12A(4), IL12B(3), IL12RB1(15), IL12RB2(3), IL18(3), IL18R1(21), JAK2(8), JUN(1), MAP2K6(3), MAPK14(5), MAPK8(2), STAT4(26), TYK2(8)	7913073	137	79	132	63	96	8	4	12	17	0	0.192	1.000	1.000
352	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	18	B2M(5), HLA-A(4), IL18(3), ITGB1(4), KLRC1(4), KLRC2(1), KLRC3(12), KLRC4(6), KLRD1(7), LAT(3), MAPK3(3), PAK1(4), PIK3CA(10), PIK3R1(3), PTK2B(12), PTPN6(5), SYK(15), VAV1(19)	7396024	120	79	114	83	83	5	3	10	17	2	0.979	1.000	1.000
353	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(10), AKR1D1(21), CYP11A1(14), CYP11B1(17), CYP11B2(12), CYP17A1(7), CYP21A2(13), HSD11B1(14), HSD11B2(2), HSD3B1(15), HSD3B2(14)	4123781	139	78	128	66	95	16	5	9	13	1	0.00121	1.000	1.000
354	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(10), AKR1D1(21), CYP11A1(14), CYP11B1(17), CYP11B2(12), CYP17A1(7), CYP21A2(13), HSD11B1(14), HSD11B2(2), HSD3B1(15), HSD3B2(14)	4123781	139	78	128	66	95	16	5	9	13	1	0.00121	1.000	1.000
355	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(29), BST1(2), CD38(6), ENPP1(13), ENPP3(14), NADK(4), NADSYN1(4), NMNAT1(1), NMNAT2(5), NMNAT3(11), NNMT(11), NNT(4), NT5C1A(6), NT5C1B(24), NT5C2(3), NT5E(6), NT5M(2), NUDT12(5), QPRT(6)	9184446	156	78	149	71	99	11	6	18	22	0	0.156	1.000	1.000
356	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG12(2), ATG3(1), ATG5(2), ATG7(11), BECN1(3), IFNA1(1), IFNA10(2), IFNA13(1), IFNA14(8), IFNA16(11), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA5(4), IFNA6(3), IFNA7(6), IFNA8(3), IFNG(4), PIK3C3(3), PIK3R4(6), PRKAA1(1), PRKAA2(32), ULK1(11), ULK2(7), ULK3(1)	8906155	134	78	128	72	93	8	6	15	12	0	0.445	1.000	1.000
357	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(5), CS(2), DLAT(4), DLD(3), DLST(1), FH(3), IDH2(2), IDH3A(3), IDH3B(2), IDH3G(2), MDH1(3), MDH2(4), OGDH(9), PC(14), PDHA1(4), PDHA2(20), PDHB(1), PDHX(2), PDK1(2), PDK2(4), PDK3(6), PDK4(8), PDP2(5), SDHA(4), SDHC(3), SDHD(1), SUCLG1(4), SUCLG2(3)	12129700	124	78	121	65	78	6	8	15	17	0	0.497	1.000	1.000
358	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(5), FUCA1(3), GLB1(10), HEXA(5), HEXB(4), LCT(54), MAN2C1(4), MANBA(7), NEU1(6), NEU2(19), NEU3(4), NEU4(16)	7028228	137	78	135	73	98	13	1	13	11	1	0.403	1.000	1.000
359	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	21	CSNK2A1(2), ELK1(3), FOS(2), GRB2(2), HRAS(3), IL2(4), IL2RA(7), IL2RB(12), IL2RG(3), JAK1(7), JAK3(11), JUN(1), LCK(15), MAPK3(3), MAPK8(2), RAF1(11), SHC1(2), SOS1(10), STAT5A(3), STAT5B(5), SYK(15)	9499189	123	77	120	70	73	13	6	19	12	0	0.676	1.000	1.000
360	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(3), ATP6V0C(1), CAT(8), EPX(9), LPO(20), MPO(12), PRDX1(3), PRDX2(3), PRDX6(4), SHMT1(2), SHMT2(3), TPO(47)	5044091	115	77	111	74	85	10	1	7	12	0	0.444	1.000	1.000
361	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	AKT1(4), PIK3CA(10), PIK3R1(3), PLCB1(58), PLCG1(9), PRKCA(9), VAV1(19)	5486267	112	77	103	59	85	4	2	9	10	2	0.423	1.000	1.000
362	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	27	ATF1(5), CREB5(9), DUSP4(3), DUSP6(2), DUSP9(3), EEF2K(6), GRB2(2), MAP2K2(5), MAPK1(4), MAPK3(3), MKNK1(6), MKNK2(4), MOS(6), NFKB1(6), RAP1A(1), RPS6KA1(9), RPS6KA2(6), RPS6KA3(2), SHC1(2), SOS1(10), SOS2(13), TRAF3(5)	11567996	112	77	110	77	74	11	3	13	11	0	0.984	1.000	1.000
363	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	CALM1(1), CALM2(1), CDKN1A(3), GNAQ(6), MARCKS(1), NFATC1(17), NFATC2(12), NFATC3(11), NFATC4(18), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKCA(9), SP1(5), SP3(1), SYT1(23)	8931852	128	76	120	56	83	12	7	11	14	1	0.205	1.000	1.000
364	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(6), ALOX15(10), ALOX15B(9), ALOX5(14), ALOX5AP(1), DPEP1(4), GGT1(8), LTA4H(5), PLA2G2A(2), PLA2G6(13), PTGDS(3), PTGIS(18), PTGS1(20), PTGS2(13), TBXAS1(16)	6367246	142	76	138	81	93	12	4	15	18	0	0.0847	1.000	1.000
365	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(5), BHMT(8), CBS(7), CTH(1), DNMT1(19), DNMT3A(9), DNMT3B(13), MARS(8), MARS2(4), MAT1A(6), MAT2B(2), MTAP(5), MTFMT(2), MTR(12), SRM(1), TAT(21)	8928478	123	76	121	54	76	11	8	12	15	1	0.0657	1.000	1.000
366	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(9), CYP2A13(13), CYP2A6(11), CYP2A7(9), NAT1(2), NAT2(10), XDH(61)	3426350	115	75	106	79	90	5	6	3	11	0	0.199	1.000	1.000
367	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	C9orf47(3), CNR1(12), CNR2(6), DNMT1(19), MTNR1A(10), MTNR1B(8), PTAFR(2), PTGDR(12), PTGER2(7), PTGER4(3), PTGFR(21), PTGIR(5), TBXA2R(4)	4758781	112	75	107	88	77	16	4	8	7	0	0.469	1.000	1.000
368	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(4), CARS(9), DARS(4), EPRS(13), FARS2(6), GARS(6), HARS(8), IARS(10), KARS(4), LARS(13), LARS2(5), MARS(8), MARS2(4), NARS(2), QARS(6), RARS(7), SARS(5), TARS(5), WARS(5), WARS2(4), YARS(3)	13730362	131	74	125	60	77	13	6	16	17	2	0.256	1.000	1.000
369	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(1), ERBB4(59), NRG2(9), NRG3(24), PRKCA(9), PSEN1(3)	3808560	105	74	94	39	76	5	3	6	15	0	0.0327	1.000	1.000
370	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	21	AKT1(4), BCL2(3), BCR(14), CRKL(2), FOS(2), GRB2(2), HRAS(3), JAK2(8), JUN(1), MAP2K4(4), MAP3K1(4), MAPK3(3), MAPK8(2), MYC(5), PIK3CA(10), PIK3R1(3), RAF1(11), SOS1(10), STAT1(5), STAT5A(3), STAT5B(5)	11600861	104	74	102	56	52	14	8	16	13	1	0.813	1.000	1.000
371	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	29	ANPEP(25), G6PD(4), GCLC(5), GCLM(2), GGT1(8), GPX3(2), GPX5(19), GSS(9), GSTA1(7), GSTA2(3), GSTA3(1), GSTA4(1), GSTM1(2), GSTM2(2), GSTM3(4), GSTM4(2), GSTM5(6), GSTO2(1), GSTP1(3), GSTT1(1), GSTZ1(1), IDH2(2), MGST1(2), MGST2(2), MGST3(2), PGD(9)	7334581	125	74	118	63	77	8	7	20	13	0	0.0780	1.000	1.000
372	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(2), B4GALNT1(5), GLB1(10), HEXA(5), HEXB(4), LCT(54), SLC33A1(6), ST3GAL1(8), ST3GAL2(1), ST3GAL5(3), ST6GALNAC3(7), ST6GALNAC4(4), ST6GALNAC5(10), ST6GALNAC6(2), ST8SIA1(1), ST8SIA5(12)	7030462	134	74	132	82	90	12	1	19	12	0	0.600	1.000	1.000
373	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(23), CPT1A(14), LEP(4), LEPR(31), PRKAA1(1), PRKAA2(32), PRKAB1(2), PRKAB2(2), PRKAG1(3), PRKAG2(8)	6219439	120	74	112	58	82	5	3	11	19	0	0.505	1.000	1.000
374	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(17), CALM1(1), CALM2(1), CAPN2(6), CAPNS1(2), CAPNS2(1), EP300(19), HDAC1(2), HDAC2(2), MEF2D(6), NFATC1(17), NFATC2(12), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKCA(9), SYT1(23)	10461393	129	74	122	59	84	7	9	13	16	0	0.265	1.000	1.000
375	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(20), AP2A1(2), AP2M1(3), BIN1(5), CALM1(1), CALM2(1), DNM1(10), EPN1(6), EPS15(4), NME1(1), PICALM(2), PPP3CA(5), PPP3CB(4), PPP3CC(2), SYNJ1(23), SYNJ2(22), SYT1(23)	9128501	134	74	128	63	91	9	5	16	13	0	0.260	1.000	1.000
376	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	CHUK(2), IKBKB(4), IL1A(5), IL1R1(12), IRAK1(5), MAP3K1(4), MAP3K7(1), MYD88(1), NFKB1(6), NFKBIA(2), RELA(4), RIPK1(3), TLR4(42), TNF(1), TNFAIP3(2), TNFRSF1A(4), TNFRSF1B(4), TRAF6(4)	10247356	106	74	99	64	74	7	4	10	11	0	0.760	1.000	1.000
377	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(1), ASNS(9), CA1(9), CA12(3), CA2(12), CA3(6), CA4(3), CA5A(3), CA5B(1), CA6(4), CA7(2), CA8(6), CA9(8), CPS1(29), CTH(1), GLS(2), GLS2(3), GLUD1(2), GLUL(1), HAL(14)	8046098	119	74	115	63	83	6	4	16	10	0	0.504	1.000	1.000
378	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(36), CD44(5), CSF1(12), FCGR3A(9), IL1B(8), IL6R(3), SELL(12), SPN(5), TGFB1(2), TGFB2(3), TNF(1), TNFRSF1A(4), TNFRSF1B(4), TNFRSF8(19), TNFSF8(3)	5536832	126	74	119	62	92	7	6	5	16	0	0.0743	1.000	1.000
379	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(29), CD28(2), CD3D(7), CD3E(2), CD3G(1), CD8A(2), ICAM1(2), ITGAL(27), ITGB2(17), PTPRC(36), THY1(1)	4542831	126	74	116	54	84	8	4	7	21	2	0.00854	1.000	1.000
380	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(29), CD28(2), CD3D(7), CD3E(2), CD3G(1), CD4(9), ICAM1(2), ITGAL(27), ITGB2(17), PTPRC(36), THY1(1)	4762451	133	74	122	59	88	8	4	8	23	2	0.0105	1.000	1.000
381	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(34), FHL5(13), FSHB(9), FSHR(21), GNAS(33), XPO1(3)	4054852	113	73	104	51	77	12	6	8	10	0	0.192	1.000	1.000
382	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(20), GABRA2(19), GABRA3(24), GABRA4(15), GABRA5(4), GABRA6(29), PRKCE(7)	3305458	118	73	102	61	86	6	3	13	8	2	0.275	1.000	1.000
383	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(3), CAT(8), EPX(9), LPO(20), MPO(12), MTHFR(3), PRDX6(4), SHMT1(2), SHMT2(3), TPO(47)	4979106	111	73	107	73	84	9	1	7	10	0	0.483	1.000	1.000
384	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(9), LPO(20), MPO(12), PRDX1(3), PRDX2(3), PRDX6(4), TPO(47), TYR(11)	4120139	109	73	105	68	79	11	1	5	13	0	0.484	1.000	1.000
385	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	15	ACTA1(4), ACTN1(8), ACTN2(21), CAPN1(5), CAPNS1(2), CAPNS2(1), ITGA1(23), ITGB1(4), ITGB3(16), PTK2(7), PXN(2), SPTAN1(10), SRC(2), TLN1(12)	11836369	117	73	115	76	75	11	5	10	15	1	0.525	1.000	1.000
386	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(5), ICAM1(2), ITGAL(27), ITGAM(25), ITGB2(17), SELE(33), SELL(12)	4384333	121	72	120	60	87	6	3	6	17	2	0.0738	1.000	1.000
387	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(1), ALDOB(14), ALDOC(4), FBP1(3), FBP2(2), G6PD(4), GPI(3), H6PD(7), PFKP(2), PGD(9), PGLS(3), PGM1(6), PGM3(1), PRPS1(3), PRPS1L1(13), PRPS2(3), RBKS(4), TAL1(9), TALDO1(3), TKT(6)	8709126	100	72	96	73	65	7	4	10	14	0	0.767	1.000	1.000
388	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(6), GTF2A1(2), GTF2B(5), GTF2E1(3), GTF2F1(5), HDAC3(5), NCOA1(9), NCOA2(13), NCOA3(19), NCOR2(28), POLR2A(13), RARA(4), RXRA(4), TBP(4)	10591405	120	72	117	55	93	4	5	10	8	0	0.218	1.000	1.000
389	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(16), APOA1(1), APOA4(9), APOC1(3), APOC2(1), APOC3(2), APOE(1), CETP(6), CYP7A1(8), DGAT1(1), HMGCR(4), LDLR(17), LIPC(10), LPL(6), LRP1(47), SCARB1(5), SOAT1(3)	11782522	140	72	137	87	80	20	8	16	14	2	0.565	1.000	1.000
390	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	12	APC(27), CDH1(6), CREBBP(24), EP300(19), MAP3K7(1), MAPK3(3), SKIL(3), TGFB1(2), TGFB2(3), TGFB3(3), TGFBR2(9)	10648246	100	72	100	53	51	14	7	15	13	0	0.934	1.000	1.000
391	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	18	ABL1(15), ATM(16), BRCA1(16), CDKN1A(3), CHEK1(2), CHEK2(2), JUN(1), MAPK8(2), MDM2(4), MRE11A(5), NFKB1(6), NFKBIA(2), RAD50(6), RBBP8(5), RELA(4), TP73(6)	12304033	95	71	94	48	47	12	3	19	14	0	0.909	1.000	1.000
392	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOA(1), ALDOB(14), ALDOC(4), FBP1(3), FBP2(2), GOT1(6), GOT2(6), GPT(4), GPT2(2), MDH1(3), MDH2(4), ME1(22), ME2(2), ME3(8), PGK1(3), PKLR(14), TKT(6), TPI1(1)	7718937	105	71	102	60	74	11	4	6	9	1	0.206	1.000	1.000
393	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(8), ACTN2(21), BCAR1(5), CSK(1), CTNNA1(3), CTNNA2(28), CTNNB1(17), PTK2(7), PXN(2), SRC(2), VCL(9)	8056585	103	71	98	61	62	8	8	11	13	1	0.462	1.000	1.000
394	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD28(2), CD3D(7), CD3E(2), CD3G(1), CD80(4), CD86(25), CTLA4(2), GRB2(2), HLA-DRA(13), HLA-DRB1(5), ICOS(3), IL2(4), ITK(25), LCK(15), PIK3CA(10), PIK3R1(3), PTPN11(10)	5454390	133	71	126	48	88	8	2	18	15	2	0.0677	1.000	1.000
395	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	13	AKT1(4), CAT(8), GH1(5), GHR(43), HRAS(3), IGF1(11), IGF1R(15), PIK3CA(10), PIK3R1(3), SHC1(2)	5668311	104	71	95	45	71	11	2	13	6	1	0.173	1.000	1.000
396	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CCR5(10), CD2(29), CD3D(7), CD3E(2), CD3G(1), CD4(9), CXCR3(4), IFNG(4), IL12A(4), IL12B(3), IL12RB1(15), IL12RB2(3), JAK2(8), STAT4(26), TYK2(8)	6208723	133	71	123	60	88	10	4	10	21	0	0.0588	1.000	1.000
397	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(10), PARK2(11), SNCA(2), SNCAIP(61), UBE2E2(4), UBE2F(5), UBE2G2(1), UBE2L3(1), UBE2L6(2)	2748962	97	71	88	40	73	10	3	5	6	0	0.0981	1.000	1.000
398	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	21	CSNK2A1(2), FOS(2), GRB2(2), HRAS(3), JAK2(8), JUN(1), MAPK3(3), MPL(9), PIK3CA(10), PIK3R1(3), PLCG1(9), PRKCA(9), RAF1(11), RASA1(5), SHC1(2), SOS1(10), STAT1(5), STAT3(11), STAT5A(3), STAT5B(5), THPO(10)	12415943	123	71	120	67	67	12	8	24	11	1	0.916	1.000	1.000
399	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(5), CARM1(7), CBS(7), CTH(1), GGT1(8), HEMK1(4), LCMT1(4), LCMT2(1), MARS(8), MARS2(4), MAT1A(6), MAT2B(2), METTL2B(5), METTL6(2), PAPSS1(4), PAPSS2(5), PRMT2(2), PRMT3(5), PRMT5(7), PRMT7(4), PRMT8(10), SCLY(3), SEPHS1(2), SEPHS2(2), WBSCR22(2)	10680917	110	70	108	61	65	13	5	15	12	0	0.427	1.000	1.000
400	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(9), CARS2(4), CDO1(6), CTH(1), GOT1(6), GOT2(6), LDHA(5), LDHAL6A(6), LDHAL6B(6), LDHB(2), LDHC(7), MPST(2), SDS(3), SULT1B1(11), SULT1C2(7), SULT1C4(15), SULT4A1(10)	5361463	106	69	102	33	69	5	11	8	13	0	0.00138	1.000	1.000
401	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	B3GNT1(3), B3GNT2(2), B3GNT3(7), B3GNT4(4), B3GNT5(2), B4GALT1(2), B4GALT2(2), B4GALT3(3), B4GALT4(3), FUT1(4), FUT2(4), FUT3(8), FUT4(3), FUT5(8), FUT6(4), FUT7(2), FUT9(29), GCNT2(1), ST3GAL6(4), ST8SIA1(1)	6824352	96	69	91	54	56	12	7	11	9	1	0.381	1.000	1.000
402	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(16), AOC2(9), AOC3(9), CES1(21), DDHD1(8), ESCO1(2), ESCO2(4), LIPA(5), NAT6(5), PLA1A(10), PNPLA3(3), PPME1(1), PRDX6(4), SH3GLB1(2)	10815802	99	69	95	57	74	4	7	6	8	0	0.792	1.000	1.000
403	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	20	CSNK2A1(2), ELK1(3), FOS(2), GRB2(2), HRAS(3), INSR(23), IRS1(5), JUN(1), MAPK3(3), MAPK8(2), PIK3CA(10), PIK3R1(3), PTPN11(10), RAF1(11), RASA1(5), SHC1(2), SLC2A4(8), SOS1(10), SRF(3)	10585461	108	69	104	59	48	17	6	27	9	1	0.920	1.000	1.000
404	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(7), CREBBP(24), EP300(19), NCOA3(19), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), RARA(4), RXRA(4)	8838285	104	67	104	57	62	8	5	17	12	0	0.860	1.000	1.000
405	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	9	EGF(22), EGFR(25), MAP3K1(4), MAPK14(5), NCOR2(28), RARA(4), RXRA(4), THRA(2), THRB(18)	6988569	112	67	110	61	77	11	3	9	12	0	0.528	1.000	1.000
406	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	14	CSF2RB(24), FOS(2), GRB2(2), HRAS(3), IL3(3), IL3RA(8), JAK2(8), MAPK3(3), PTPN6(5), RAF1(11), SHC1(2), SOS1(10), STAT5A(3), STAT5B(5)	7164756	89	67	87	49	49	7	6	11	16	0	0.663	1.000	1.000
407	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD28(2), CD86(25), HLA-DRA(13), HLA-DRB1(5), IFNG(4), IFNGR1(3), IFNGR2(4), IL12A(4), IL12B(3), IL12RB1(15), IL12RB2(3), IL18(3), IL18R1(21), IL2(4), IL2RA(7), IL4(1), IL4R(18)	5388315	135	67	127	50	100	6	0	10	19	0	0.00674	1.000	1.000
408	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	AKT1(4), CHRNB1(4), CHRNG(3), MUSK(36), PIK3CA(10), PIK3R1(3), PTK2(7), PTK2B(12), RAPSN(1), SRC(2), TERT(9)	6942853	91	66	87	79	59	7	0	15	9	1	0.993	1.000	1.000
409	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	19	CSNK2A1(2), ELK1(3), FOS(2), GRB2(2), HRAS(3), IGF1(11), IGF1R(15), IRS1(5), JUN(1), MAPK3(3), MAPK8(2), PIK3CA(10), PIK3R1(3), PTPN11(10), RAF1(11), RASA1(5), SHC1(2), SOS1(10), SRF(3)	10236951	103	66	97	53	49	19	3	24	7	1	0.850	1.000	1.000
410	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	18	ABCB1(39), AKT1(4), ATM(16), BAX(4), CDKN1A(3), CPB2(1), CSNK1A1(5), CSNK1D(3), HIC1(2), HIF1A(4), HSPA1A(1), IGFBP3(3), MAPK8(2), MDM2(4), NFKBIB(1), NQO1(2)	8512093	94	66	84	45	56	7	3	13	14	1	0.623	1.000	1.000
411	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GSR(2), GSS(9), NFKB1(6), NOX1(13), RELA(4), TNF(1), XDH(61)	4206671	96	65	91	51	71	6	4	7	8	0	0.157	1.000	1.000
412	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(9), GBA(7), LPO(20), MPO(12), PRDX6(4), TPO(47)	3577255	99	65	95	67	75	9	1	5	9	0	0.564	1.000	1.000
413	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	18	AKT1(4), EIF2B5(3), EIF2S1(1), EIF2S3(2), EIF4EBP1(1), GSK3B(3), IGF1(11), IGF1R(15), INPPL1(16), PDK2(4), PDPK1(5), PIK3CA(10), PIK3R1(3), PPP2CA(1), RPS6(1), RPS6KB1(4)	8036600	84	65	78	46	50	11	6	9	7	1	0.694	1.000	1.000
414	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	20	CSNK2A1(2), ELK1(3), FOS(2), GRB2(2), HRAS(3), IL6(2), IL6R(3), IL6ST(11), JAK1(7), JAK2(8), JAK3(11), JUN(1), MAPK3(3), PTPN11(10), RAF1(11), SHC1(2), SOS1(10), SRF(3), STAT3(11)	9819721	105	65	103	62	45	16	5	28	11	0	0.968	1.000	1.000
415	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	ADAM17(1), APC(27), AXIN1(10), BTRC(4), CTNNB1(17), DLL1(3), DVL1(1), FZD1(5), GSK3B(3), NOTCH1(9), PSEN1(3), WNT1(2)	9023786	85	65	84	52	41	10	7	12	15	0	0.942	1.000	1.000
416	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	20	AKT1(4), CCND1(2), CCNE1(4), CDK2(1), CDK6(2), CDKN1A(3), CDKN1B(1), E2F1(6), HRAS(3), MAPK1(4), MAPK3(3), NFKB1(6), NFKBIA(2), PAK1(4), PIK3CA(10), PIK3R1(3), RAF1(11), RB1(10), RELA(4), TFDP1(2)	8140669	85	65	83	49	38	10	7	13	14	3	0.844	1.000	1.000
417	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(4), ALG5(3), B4GALT1(2), B4GALT2(2), B4GALT3(3), B4GALT5(3), DDOST(2), DPAGT1(2), DPM1(1), FUT8(8), MAN1A1(19), MAN1B1(4), MGAT1(3), MGAT2(3), MGAT3(12), MGAT4A(8), MGAT4B(1), MGAT5(6), RPN2(4), ST6GAL1(8)	8528020	98	64	95	63	62	11	3	11	11	0	0.716	1.000	1.000
418	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3D(7), CD3E(2), CD3G(1), CD4(9), FYN(8), HLA-DRA(13), HLA-DRB1(5), LCK(15), PTPRC(36), ZAP70(8)	3783076	104	64	98	40	69	8	3	9	14	1	0.0197	1.000	1.000
419	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(37), MAP2(21), PPP1CA(3), PPP2CA(1), PRKACB(4), PRKACG(10), PRKAG1(3), PRKAR2A(1), PRKAR2B(5), PRKCE(7)	7722806	92	63	91	52	50	10	7	11	13	1	0.918	1.000	1.000
420	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM1(1), CALM2(1), CAMK1(5), CAMK1G(12), CAMK2A(6), CAMK2B(6), CAMK2D(6), CAMK2G(5), CAMK4(17), CAMKK1(3), CAMKK2(9), SYT1(23)	4947143	94	63	88	70	64	8	3	9	10	0	0.868	1.000	1.000
421	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	19	ACO1(8), ACO2(5), CS(2), DLD(3), DLST(1), FH(3), IDH2(2), IDH3A(3), IDH3B(2), IDH3G(2), MDH1(3), MDH2(4), PC(14), PCK1(25), SDHA(4), SUCLG1(4), SUCLG2(3)	8473213	88	63	85	57	58	2	6	10	12	0	0.800	1.000	1.000
422	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(5), BHMT(8), CBS(7), CTH(1), DNMT1(19), DNMT3A(9), DNMT3B(13), MARS(8), MARS2(4), MAT1A(6), MAT2B(2), MTR(12)	7512788	94	63	93	38	56	9	7	10	11	1	0.0419	1.000	1.000
423	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	ATF1(5), CASP2(1), CHUK(2), CRADD(2), IKBKB(4), JUN(1), LTA(5), MAP2K3(9), MAP2K4(4), MAP2K6(3), MAP3K1(4), MAP4K2(7), MAPK14(5), MAPK8(2), NFKB1(6), NFKBIA(2), RELA(4), RIPK1(3), TNF(1), TNFRSF1A(4), TRAF2(2)	10155954	76	63	76	46	45	10	3	8	9	1	0.721	1.000	1.000
424	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	16	DNAJA3(5), HSPA1A(1), IFNG(4), IFNGR1(3), IFNGR2(4), IKBKB(4), JAK2(8), NFKB1(6), NFKBIA(2), RB1(10), RELA(4), TNF(1), TNFRSF1A(4), TNFRSF1B(4), USH1C(23), WT1(10)	7165911	93	63	88	39	41	9	4	12	25	2	0.263	1.000	1.000
425	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(5), GNAQ(6), GNB1(1), HTR2C(14), PLCB1(58), TUB(10)	3048869	94	63	85	42	71	3	2	9	9	0	0.0574	1.000	1.000
426	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(6), CHUK(2), IFNG(4), IKBKB(4), IL2(4), IL4(1), JUN(1), MAP3K1(4), MAP3K5(23), MAP4K5(5), MAPK14(5), MAPK8(2), NFKB1(6), NFKBIA(2), RELA(4), TNFRSF9(4), TNFSF9(4), TRAF2(2)	8161439	83	62	77	41	45	6	2	12	18	0	0.573	1.000	1.000
427	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	AKT1(4), CASP9(2), CHUK(2), GH1(5), GHR(43), NFKB1(6), NFKBIA(2), PDPK1(5), PIK3CA(10), PIK3R1(3), PPP2CA(1), RELA(4)	5968669	87	62	80	44	58	8	4	10	6	1	0.591	1.000	1.000
428	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	19	AKT1(4), APAF1(6), ATM(16), BAX(4), BCL2(3), CASP3(2), CASP7(4), CASP9(2), CYCS(1), EIF2S1(1), PRKCA(9), PTK2(7), PXN(2), STAT1(5), TLN1(12)	11283078	78	62	75	44	43	10	3	11	11	0	0.801	1.000	1.000
429	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	15	AKT1(4), MAP2K2(5), MAP2K3(9), MAP2K6(3), MAP3K1(4), MAPK1(4), MAPK14(5), MAPK3(3), NFKB1(6), PIK3CA(10), PIK3R1(3), RB1(10), RELA(4), SP1(5)	7916536	75	62	73	45	34	11	4	9	14	3	0.940	1.000	1.000
430	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	16	B3GAT1(8), B3GAT2(3), B3GAT3(4), CHPF(4), CHST11(7), CHST12(7), CHST13(3), CHST14(3), CHST3(2), CHST7(3), CHSY1(9), DSE(20), XYLT1(12), XYLT2(5)	5811712	90	62	90	62	57	13	4	8	8	0	0.545	1.000	1.000
431	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(13), POLR1B(8), POLR1C(1), POLR2A(13), POLR2B(14), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(2), POLR2H(2), POLR2J(2), POLR2L(1), POLR3A(8), POLR3B(15), POLR3G(1), POLR3GL(3), POLR3H(1), POLR3K(1)	10017523	88	62	85	49	50	9	6	17	6	0	0.740	1.000	1.000
432	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(29), CD38(6), ENPP1(13), ENPP3(14), NADSYN1(4), NMNAT1(1), NMNAT2(5), NNMT(11), NNT(4), NT5E(6), NT5M(2), QPRT(6)	6212326	101	62	95	46	61	9	5	12	14	0	0.258	1.000	1.000
433	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(24), EP300(19), LPL(6), NCOA1(9), NCOA2(13), PPARG(12), RXRA(4)	7931311	87	62	84	36	52	11	4	12	8	0	0.395	1.000	1.000
434	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	14	AKT1(4), AKT2(8), AKT3(3), CDKN1A(3), ELK1(3), GRB2(2), HRAS(3), MAP2K2(5), NGFR(8), NTRK1(16), PIK3CA(10), PIK3CD(8), SHC1(2), SOS1(10)	6493871	85	62	83	41	38	17	4	17	9	0	0.520	1.000	1.000
435	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(2), ALDH18A1(8), ARG1(2), ARG2(2), ASL(7), CKM(3), CKMT1A(1), CKMT2(5), CPS1(29), GAMT(4), GATM(6), GLUD1(2), NAGS(1), OAT(4), ODC1(3), OTC(4), PYCR1(1), SMS(5)	7380470	89	62	86	41	51	9	5	13	11	0	0.217	1.000	1.000
436	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(3), GALNS(5), GLB1(10), GNS(2), GUSB(5), HEXA(5), HEXB(4), IDS(9), IDUA(6), LCT(54), NAGLU(4)	6107486	107	61	105	62	80	8	0	10	9	0	0.515	1.000	1.000
437	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(5), CYSLTR2(4), GPR161(8), GPR171(10), GPR18(5), GPR34(3), GPR39(12), GPR45(8), GPR65(14), GPR68(3), GPR75(6)	4172726	78	61	75	41	53	5	3	8	9	0	0.0139	1.000	1.000
438	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(23), ACACB(23), FASN(25), MCAT(2), OLAH(11), OXSM(2)	6754738	86	61	84	54	52	9	3	8	14	0	0.605	1.000	1.000
439	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(4), ACP2(3), ACP5(3), ACP6(12), ACPP(9), ACPT(3), ENPP1(13), ENPP3(14), FLAD1(11), LHPP(1), MTMR1(6), MTMR2(3), MTMR6(2), TYR(11)	6398037	95	61	91	29	62	5	5	7	16	0	0.0150	1.000	1.000
440	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CD4(9), CSF1(12), CSF2(2), CSF3(4), HLA-DRA(13), HLA-DRB1(5), IFNA1(1), IFNB1(6), IFNG(4), IL10(2), IL11(3), IL12A(4), IL12B(3), IL13(2), IL15(3), IL1A(5), IL2(4), IL3(3), IL4(1), IL5(4), IL6(2), IL7(5), LTA(5), PDGFA(1), TGFB1(2), TGFB2(3), TGFB3(3), TNF(1)	5614094	112	61	109	58	73	5	3	11	20	0	0.0288	1.000	1.000
441	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	21	AKT1(4), AP2A1(2), AP2M1(3), BTK(15), EEA1(3), GRASP(3), GSK3A(1), GSK3B(3), LYN(11), PDPK1(5), PFKL(3), PFKP(2), PLCG1(9), PRKCE(7), PRKCZ(3), RAB5A(2), RPS6KB1(4), VAV2(5)	10372921	85	61	83	60	49	9	4	7	16	0	0.794	1.000	1.000
442	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(3), KHK(2), LCT(54), MPI(1), PGM1(6), PYGL(9), PYGM(14), TPI1(1), TREH(2)	5632350	92	60	91	71	66	7	1	11	7	0	0.786	1.000	1.000
443	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(9), ASPH(6), COPS5(3), EDN1(9), EP300(19), EPO(5), HIF1A(4), JUN(1), LDHA(5), NOS3(20), P4HB(3), VHL(4)	7297451	88	60	85	41	55	5	5	10	13	0	0.588	1.000	1.000
444	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(8), ACOX3(13), FADS2(4), PLA2G12B(3), PLA2G1B(1), PLA2G2A(2), PLA2G2D(5), PLA2G2E(5), PLA2G2F(6), PLA2G3(19), PLA2G4A(16), PLA2G5(2), PLA2G6(13)	4320806	97	60	97	46	66	7	2	6	15	1	0.0649	1.000	1.000
445	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(6), BIRC2(6), BIRC3(7), CASP10(6), CASP3(2), CASP7(4), CASP8(9), CASP9(2), DFFA(2), DFFB(2), GZMB(3), PRF1(14), SCAP(12), SREBF1(5), SREBF2(10)	7765698	90	60	86	51	52	8	6	14	10	0	0.694	1.000	1.000
446	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(7), F13B(35), HSD17B2(13), HSD17B3(5), HSD17B4(6), HSD17B7(1), HSD3B1(15), HSD3B2(14)	3418004	96	60	90	38	68	6	6	4	12	0	0.0211	1.000	1.000
447	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARFGAP1(5), ARFGAP3(3), ARFGEF2(15), CLTA(1), CLTB(1), COPA(10), GBF1(15), GPLD1(27), KDELR1(1), KDELR3(2)	6983853	80	59	78	46	41	7	3	16	13	0	0.701	1.000	1.000
448	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM1(1), CALM2(1), CCL2(3), CCR5(10), CXCL12(2), CXCR4(3), FOS(2), GNAQ(6), JUN(1), MAPK14(5), MAPK8(2), PLCG1(9), PRKCA(9), PTK2B(12), SYT1(23)	5899387	89	59	83	69	60	7	5	12	5	0	0.927	1.000	1.000
449	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	20	CCNA1(16), CCND1(2), CCND2(7), CCND3(2), CCNE1(4), CCNH(1), CDC25A(8), CDK2(1), CDK6(2), CDK7(2), CDKN1A(3), CDKN1B(1), CDKN2C(1), E2F1(6), RB1(10), RBL1(14), TFDP1(2)	6353530	82	59	82	30	46	4	7	12	11	2	0.0720	1.000	1.000
450	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	MRPL13(3), MRPS7(1), RPL10A(1), RPL10L(8), RPL11(4), RPL12(1), RPL13(1), RPL13A(2), RPL14(1), RPL18(3), RPL18A(2), RPL19(1), RPL21(2), RPL26(1), RPL27(3), RPL27A(1), RPL29(1), RPL3(2), RPL30(1), RPL32(1), RPL35(1), RPL35A(1), RPL36AL(1), RPL38(1), RPL39(1), RPL3L(5), RPL6(1), RPL7(2), RPS11(1), RPS13(1), RPS15A(1), RPS16(1), RPS18(2), RPS2(2), RPS20(2), RPS23(1), RPS24(1), RPS26(1), RPS27(2), RPS29(1), RPS3A(1), RPS5(1), RPS6(1), RPS7(4), RPS8(1), RPSA(1)	9608800	78	59	78	56	39	7	6	15	11	0	0.942	1.000	1.000
451	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP5O(5), ATP6AP1(3), ATP6V0A1(13), ATP6V0A4(23), ATP6V0C(1), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(7), ATP6V1H(5), FDXR(10), SHMT1(2)	6838473	90	59	89	55	52	4	6	13	15	0	0.609	1.000	1.000
452	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	15	AKT1(4), AKT2(8), AKT3(3), GRB2(2), ILK(2), MAPK1(4), MAPK3(3), PDK1(2), PIK3CA(10), PIK3CD(8), PTK2B(12), RBL2(6), SHC1(2), SOS1(10)	8413700	76	59	75	47	39	9	3	19	6	0	0.938	1.000	1.000
453	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(5), ATP6AP1(3), ATP6V0A1(13), ATP6V0A4(23), ATP6V0C(1), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(7), ATP6V1H(5), SHMT1(2)	6426898	80	58	79	51	45	3	6	12	14	0	0.723	1.000	1.000
454	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(1), POLD1(7), POLD2(2), POLE(16), POLG(8), POLL(10), POLQ(26)	7138206	70	58	69	38	39	8	2	13	8	0	0.556	1.000	1.000
455	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(5), ATP6AP1(3), ATP6V0A1(13), ATP6V0A4(23), ATP6V0C(1), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(7), ATP6V1H(5), SHMT1(2)	6426898	80	58	79	51	45	3	6	12	14	0	0.723	1.000	1.000
456	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(7), B3GALNT1(6), B3GALT5(1), FUT1(4), FUT2(4), FUT9(29), GBGT1(3), GLA(2), HEXA(5), HEXB(4), NAGA(5), ST3GAL1(8), ST3GAL2(1), ST8SIA1(1)	4586406	80	58	75	49	47	10	5	13	5	0	0.596	1.000	1.000
457	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	12	CREBBP(24), DAXX(10), HRAS(3), PAX3(3), PML(3), RARA(4), RB1(10), SIRT1(2), SP100(12), TNF(1), TNFRSF1A(4), TNFRSF1B(4)	7686287	80	58	80	37	30	13	7	13	15	2	0.511	1.000	1.000
458	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	CISH(4), IL6(2), IL6R(3), JAK1(7), JAK2(8), JAK3(11), PIAS3(6), PTPRU(23), REG1A(8), SRC(2), STAT3(11)	6479384	85	58	84	54	48	10	3	10	14	0	0.739	1.000	1.000
459	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BAG4(3), BIRC2(6), BIRC3(7), CASP3(2), CASP8(9), CFLAR(4), JUN(1), MAP2K4(4), MAP3K3(8), MAP3K7(1), NFKB1(6), NFKB2(5), NFKBIA(2), NFKBIB(1), NFKBIL1(2), NR2C2(1), RALBP1(3), RIPK1(3), TNF(1), TNFAIP3(2), TNFRSF1A(4), TNFRSF1B(4), TRAF2(2)	11547447	81	58	80	57	46	3	8	13	11	0	0.978	1.000	1.000
460	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(5), ATP6AP1(3), ATP6V0A1(13), ATP6V0A4(23), ATP6V0C(1), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(7), ATP6V1H(5), SHMT1(2)	6426898	80	58	79	51	45	3	6	12	14	0	0.723	1.000	1.000
461	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	13	ABL1(15), E2F1(6), MDM2(4), MYC(5), PIK3CA(10), PIK3R1(3), POLR1A(13), POLR1B(8), POLR1C(1), RB1(10), TBX2(6), TWIST1(1)	7857531	82	57	80	34	47	8	3	11	10	3	0.225	1.000	1.000
462	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	AKT1(4), GRB2(2), HRAS(3), MAPK1(4), MAPK3(3), MAPK7(4), MEF2A(3), MEF2B(2), MEF2C(3), MEF2D(6), NTRK1(16), PIK3CA(10), PIK3R1(3), PLCG1(9), RPS6KA1(9), SHC1(2)	8066485	83	57	80	65	49	12	5	9	7	1	0.986	1.000	1.000
463	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(12), CYP11A1(14), CYP11B2(12), CYP17A1(7), HSD11B1(14), HSD11B2(2), HSD3B1(15), HSD3B2(14)	2941950	90	57	85	58	66	9	1	5	9	0	0.0645	1.000	1.000
464	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(40), CYP2C9(41)	862439	81	57	73	58	61	5	2	2	11	0	0.830	1.000	1.000
465	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACAA1(6), ACOX1(8), ACOX3(13), ELOVL2(2), ELOVL5(1), ELOVL6(2), FADS2(4), FASN(25), HADHA(6), HSD17B12(4), PECR(2), SCD(4)	6109332	77	57	77	37	48	7	4	8	10	0	0.0580	1.000	1.000
466	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(6), ALDH3A1(10), ALDH3A2(3), ALDH9A1(3), ECHS1(3), EHHADH(6), HADHA(6), SDS(3)	5173131	76	57	71	35	43	9	4	11	9	0	0.137	1.000	1.000
467	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(5), ACADM(5), ACADS(5), ACADVL(1), ACSL1(8), ACSL3(8), ACSL4(5), CPT1A(14), CPT2(2), EHHADH(6), HADHA(6), PECR(2), SCP2(4), SLC25A20(1)	7229827	72	57	68	35	45	4	3	8	12	0	0.574	1.000	1.000
468	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	19	AKT1(4), CASP9(2), CDC42(2), CHUK(2), ELK1(3), H2AFX(2), HRAS(3), MAPK3(3), NFKB1(6), PIK3CA(10), PIK3R1(3), RAF1(11), RALA(1), RALBP1(3), RALGDS(10), RELA(4), RHOA(2)	7552903	71	57	69	46	37	13	2	15	3	1	0.930	1.000	1.000
469	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(6), ARHGDIB(4), BIRC2(6), BIRC3(7), CASP1(4), CASP10(6), CASP2(1), CASP3(2), CASP4(2), CASP7(4), CASP8(9), CASP9(2), CYCS(1), DFFA(2), DFFB(2), GZMB(3), LMNA(5), LMNB1(2), LMNB2(4), PRF1(14)	8328136	86	56	85	51	46	10	6	14	10	0	0.885	1.000	1.000
470	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	18	CSNK2A1(2), ELK1(3), EPO(5), EPOR(1), FOS(2), GRB2(2), HRAS(3), JAK2(8), JUN(1), MAPK3(3), MAPK8(2), PLCG1(9), PTPN6(5), RAF1(11), SHC1(2), SOS1(10), STAT5A(3), STAT5B(5)	8767714	77	56	76	48	36	8	7	15	11	0	0.925	1.000	1.000
471	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	CARM1(7), DHRS1(3), DHRS2(8), DHRS3(5), DHRS7(1), DHRSX(6), HEMK1(4), LCMT1(4), LCMT2(1), METTL2B(5), METTL6(2), PRMT2(2), PRMT3(5), PRMT5(7), PRMT7(4), PRMT8(10), WBSCR22(2)	6426475	76	56	74	41	45	10	1	13	7	0	0.459	1.000	1.000
472	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(9), IL22(2), IL22RA1(13), IL22RA2(3), JAK1(7), JAK2(8), JAK3(11), SOCS3(1), STAT1(5), STAT3(11), STAT5A(3), STAT5B(5), TYK2(8)	7778061	86	56	86	56	49	7	6	15	9	0	0.842	1.000	1.000
473	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	20	BAX(4), BCL2(3), CASP8(9), CYCS(1), MAP2K4(4), MAP3K1(4), MAPK1(4), MAPK3(3), MAPK8(2), NFKB1(6), NSMAF(6), RAF1(11), RELA(4), RIPK1(3), SMPD1(2), TNFRSF1A(4), TRAF2(2)	8370323	72	55	71	35	39	9	4	11	9	0	0.557	1.000	1.000
474	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(9), IL13(2), IL4(1), IL5(4), MAF(1), MAP2K3(9), MAPK14(5), NFATC1(17), NFATC2(12), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5)	5161279	87	55	83	56	57	8	3	5	14	0	0.633	1.000	1.000
475	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	17	CSNK2A1(2), DPM2(1), ELK1(3), FOS(2), GRB2(2), HRAS(3), JUN(1), KLK2(5), MAPK3(3), MAPK8(2), NGFR(8), PIK3CA(10), PIK3R1(3), PLCG1(9), RAF1(11), SHC1(2), SOS1(10)	7791466	77	55	75	44	37	11	3	18	7	1	0.909	1.000	1.000
476	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(4), JAK1(7), JAK2(8), JAK3(11), PIAS1(7), PIAS3(6), PTPRU(23), REG1A(8), SOAT1(3)	5825301	77	55	76	34	47	9	2	6	13	0	0.135	1.000	1.000
477	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(7), FUT1(4), FUT2(4), FUT9(29), GBGT1(3), GLA(2), HEXA(5), HEXB(4), NAGA(5), ST3GAL1(8), ST3GAL2(1), ST3GAL4(1), ST8SIA1(1)	4318655	74	54	69	40	43	10	3	12	6	0	0.343	1.000	1.000
478	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CHUK(2), CREBBP(24), EP300(19), HDAC3(5), IKBKB(4), NFKB1(6), NFKBIA(2), RELA(4), RIPK1(3), TNF(1), TNFRSF1A(4), TNFRSF1B(4), TRAF6(4)	9521393	82	54	82	39	45	10	6	13	8	0	0.483	1.000	1.000
479	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(4), GNAS(33), GNB1(1), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5), PRKCA(9)	4059172	74	53	70	41	52	8	3	6	5	0	0.726	1.000	1.000
480	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(2), CYB5R3(2), GCK(16), GFPT1(6), GNE(3), GNPDA1(1), GNPDA2(1), HEXA(5), HEXB(4), HK1(3), HK2(15), HK3(15), PGM3(1), RENBP(3), UAP1(2)	7242946	79	53	76	53	51	5	2	12	9	0	0.877	1.000	1.000
481	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(3), EGF(22), EGFR(25), HGS(5), RAB5A(2), TF(16), TFRC(4)	5473784	77	53	77	49	51	5	5	6	10	0	0.896	1.000	1.000
482	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	14	AKT1(4), GRB2(2), HRAS(3), IGF1R(15), IRS1(5), MAPK1(4), MAPK3(3), PIK3CA(10), PIK3R1(3), RAF1(11), SHC1(2), SOS1(10)	7784376	72	53	68	37	37	12	3	13	6	1	0.713	1.000	1.000
483	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	14	APAF1(6), ATM(16), BAX(4), BCL2(3), CCND1(2), CCNE1(4), CDK2(1), CDKN1A(3), E2F1(6), MDM2(4), PCNA(2), RB1(10), TIMP3(5)	7064843	66	53	65	28	26	7	4	12	15	2	0.588	1.000	1.000
484	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	17	ACTA1(4), ACTR2(3), ACTR3(2), ARPC1B(3), ARPC2(1), ARPC3(2), ARPC4(1), NCK1(2), NCKAP1(5), NTRK1(16), PIR(1), PSMA7(1), WASF1(5), WASF2(6), WASF3(14), WASL(4)	6348133	70	52	69	38	42	7	4	9	8	0	0.855	1.000	1.000
485	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(5), CD3D(7), CD3E(2), CD3G(1), GZMB(3), HLA-A(4), ICAM1(2), ITGAL(27), ITGB2(17), PRF1(14)	3717659	82	52	81	38	47	8	3	5	18	1	0.0642	1.000	1.000
486	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(4), APAF1(6), BCL2(3), CASP3(2), CASP9(2), CYCS(1), DAXX(10), FAS(5), FASLG(15), HSPB1(2), HSPB2(1), IL1A(5), MAPKAPK2(5), MAPKAPK3(5), TNF(1)	4856088	67	52	65	39	42	7	2	7	9	0	0.623	1.000	1.000
487	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	10	ATM(16), CDC25A(8), CDC25B(4), CDC25C(5), CDK2(1), CHEK1(2), MYT1(21), RB1(10), WEE1(2)	6870982	69	52	67	30	39	4	3	10	11	2	0.491	1.000	1.000
488	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	13	ACTR2(3), ACTR3(2), ARPC1B(3), ARPC2(1), ARPC3(2), ARPC4(1), CDC42(2), PAK1(4), PDGFRA(32), PIK3CA(10), PIK3R1(3), WASL(4)	5555636	67	51	66	28	43	3	3	11	6	1	0.399	1.000	1.000
489	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(22), EGFR(25), ERBB3(5), NRG1(16), UBE2D1(1)	4414469	69	51	69	45	47	2	3	7	9	1	0.951	1.000	1.000
490	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(3), B3GNT2(2), B3GNT7(6), B4GALT1(2), B4GALT2(2), B4GALT3(3), B4GALT4(3), CHST1(11), CHST2(5), CHST4(10), CHST6(4), FUT8(8), ST3GAL1(8), ST3GAL2(1), ST3GAL3(2), ST3GAL4(1)	5319249	71	51	70	51	45	14	3	4	5	0	0.692	1.000	1.000
491	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT2(1), ACOT11(11), ACYP1(1), DHRS1(3), DHRS2(8), DHRS3(5), DHRS7(1), DHRSX(6), ECHS1(3), EHHADH(6), ESCO1(2), ESCO2(4), GCDH(6), HADHA(6), NAT6(5), PNPLA3(3), SH3GLB1(2), YOD1(1)	11127647	74	51	73	46	41	11	6	11	5	0	0.917	1.000	1.000
492	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(16), AMT(1), ATIC(5), DHFR(1), FTCD(3), GART(10), MTFMT(2), MTHFD1(12), MTHFD1L(2), MTHFD2(2), MTHFR(3), MTR(12), SHMT1(2), SHMT2(3), TYMS(2)	8079674	76	51	74	44	50	6	3	8	9	0	0.644	1.000	1.000
493	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(7), CLOCK(4), CRY1(7), CRY2(7), CSNK1D(3), CSNK1E(5), NPAS2(6), NR1D1(1), PER1(8), PER2(12), PER3(12)	7252975	72	51	68	52	48	7	1	6	10	0	0.964	1.000	1.000
494	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCL11(3), CCR3(11), CD4(9), HLA-DRA(13), HLA-DRB1(5), IL1B(8), IL4(1), IL5(4), IL5RA(16), IL6(2)	2279822	72	51	66	38	55	0	1	6	10	0	0.0696	1.000	1.000
495	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	15	AKT1(4), BCAR1(5), CDKN1B(1), GRB2(2), ILK(2), ITGB1(4), MAPK1(4), MAPK3(3), PDK2(4), PDPK1(5), PIK3CA(10), PIK3R1(3), PTK2(7), SHC1(2), SOS1(10)	7844630	66	51	64	39	36	8	3	13	5	1	0.933	1.000	1.000
496	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(24), EP300(19), ESR1(6), MAPK1(4), MAPK3(3), PELP1(12), SRC(2)	6263992	70	50	70	39	42	7	5	11	5	0	0.777	1.000	1.000
497	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	AKT1(4), DPM2(1), GRB2(2), HRAS(3), KLK2(5), NTRK1(16), PIK3CA(10), PIK3R1(3), PLCG1(9), PRKCA(9), SHC1(2), SOS1(10)	6637650	74	50	72	42	42	9	3	11	8	1	0.831	1.000	1.000
498	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(9), ANKRD1(1), ATF3(1), CYR61(2), DUSP14(2), EIF4EBP1(1), HBEGF(1), IFNG(4), IFRD1(2), IL18(3), IL1A(5), IL1R1(12), JUND(1), MYOG(3), NR4A3(10), WDR1(6)	4534195	63	49	58	31	41	5	2	5	10	0	0.494	1.000	1.000
499	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(4), GRB2(2), IL2RG(3), IL4(1), IL4R(18), IRS1(5), JAK1(7), JAK3(11), RPS6KB1(4), SHC1(2), STAT6(9)	6294755	66	49	65	32	37	10	4	8	7	0	0.278	1.000	1.000
500	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(4), ENO2(5), ENO3(4), FARS2(6), GOT1(6), GOT2(6), PAH(12), TAT(21), YARS(3)	3561109	67	49	64	34	44	6	2	7	8	0	0.132	1.000	1.000
501	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(2), MAPK14(5), MAPK8(2), NFKB1(6), RELA(4), TNFRSF13B(11), TNFRSF17(7), TNFSF13B(3), TRAF2(2), TRAF3(5), TRAF5(8), TRAF6(4)	6134800	59	49	58	26	42	6	0	8	3	0	0.250	1.000	1.000
502	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(9), CHAT(20), CHKA(2), PCYT1A(3), PDHA1(4), PDHA2(20), PEMT(2), SLC18A3(2)	2931222	62	48	58	34	43	7	2	3	6	1	0.248	1.000	1.000
503	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(8), ACO2(5), AFMID(1), CS(2), GRHPR(1), HAO1(8), HAO2(15), HYI(2), MDH1(3), MDH2(4), MTHFD1(12), MTHFD1L(2), MTHFD2(2)	5716791	65	48	61	39	35	5	4	7	14	0	0.665	1.000	1.000
504	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(5), CAMK1G(12), HDAC9(45), MEF2A(3), MEF2B(2), MEF2C(3), MEF2D(6), MYOD1(1)	3182933	77	48	67	41	61	5	2	3	6	0	0.363	1.000	1.000
505	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(2), DUSP1(1), IKBKAP(7), IKBKB(4), LTA(5), MAP3K1(4), NFKB1(6), NFKBIA(2), RELA(4), RIPK1(3), TNFAIP3(2), TNFRSF1B(4), TRAF1(6), TRAF2(2), TRAF3(5)	9515594	57	48	57	49	36	6	1	6	8	0	0.994	1.000	1.000
506	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	FOS(2), JUN(1), MAPK3(3), OPRK1(23), POLR2A(13), PRKACB(4), PRKACG(10), PRKAR1A(3), PRKAR1B(4), PRKAR2A(1), PRKAR2B(5)	5485395	69	47	68	67	51	3	4	5	6	0	0.997	1.000	1.000
507	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(8), ACO2(5), CS(2), GRHPR(1), HAO1(8), HAO2(15), HYI(2), MDH1(3), MDH2(4), MTHFD1(12), MTHFD1L(2), MTHFD2(2)	5458276	64	47	60	35	35	5	3	7	14	0	0.514	1.000	1.000
508	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	AKR1B10(10), DHRS1(3), DHRS2(8), DHRS3(5), DHRS7(1), DHRSX(6), HSD3B7(5), PON1(14), PON2(3), PON3(7), RDH11(2), RDH12(2), RDH13(3), RDH14(1)	3856527	70	47	69	36	50	4	2	7	7	0	0.183	1.000	1.000
509	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(29), CD34(4), CD3D(7), CD3E(2), CD3G(1), CD4(9), CD58(1), CD8A(2), CSF3(4), IL3(3), IL6(2), KITLG(10)	2619952	74	47	66	33	52	3	2	8	9	0	0.0671	1.000	1.000
510	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(16), AMT(1), ATIC(5), ATP6V0C(1), DHFR(1), GART(10), MTHFD1(12), MTHFD1L(2), MTHFD2(2), MTHFR(3), MTR(12), SHMT1(2), SHMT2(3), TYMS(2)	7629387	72	47	70	39	47	6	3	8	8	0	0.493	1.000	1.000
511	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(3), IFNB1(6), JAK1(7), PTPRU(23), REG1A(8), STAT1(5), STAT2(6), TYK2(8)	5351023	66	47	65	36	37	8	1	8	12	0	0.333	1.000	1.000
512	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(16), CDC25A(8), CDC25B(4), CDC25C(5), CHEK1(2), MYT1(21), WEE1(2)	5870983	58	46	56	27	38	4	2	8	6	0	0.563	1.000	1.000
513	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(7), CHPT1(1), HEMK1(4), LCMT1(4), LCMT2(1), METTL2B(5), METTL6(2), PCYT1A(3), PCYT1B(9), PRMT2(2), PRMT3(5), PRMT5(7), PRMT7(4), PRMT8(10), WBSCR22(2)	5990805	66	46	64	34	38	8	3	11	6	0	0.467	1.000	1.000
514	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	11	CDK5(6), CDK5R1(1), DPM2(1), EGR1(4), HRAS(3), KLK2(5), MAP2K2(5), MAPK1(4), MAPK3(3), NGFR(8), RAF1(11)	3140623	51	45	49	29	23	8	3	9	8	0	0.474	1.000	1.000
515	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(6), ARHGAP5(13), ARHGDIB(4), CASP1(4), CASP10(6), CASP3(2), CASP8(9), CASP9(2), CYCS(1), GZMB(3), JUN(1), PRF1(14)	5517335	65	45	63	38	41	4	2	13	5	0	0.888	1.000	1.000
516	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(14), CDO1(6), CSAD(6), GAD1(14), GAD2(9), GGT1(8)	2421221	57	45	54	36	36	7	4	5	5	0	0.654	1.000	1.000
517	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	CHST11(7), CHST12(7), CHST13(3), PAPSS1(4), PAPSS2(5), SULT1A1(14), SULT1A2(3), SULT1E1(16), SULT2A1(9), SULT2B1(6), SUOX(4)	3896847	78	45	75	42	57	6	0	6	9	0	0.280	1.000	1.000
518	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(2), BLVRB(1), HMOX1(1), IL10(2), IL10RA(9), IL10RB(7), IL1A(5), IL6(2), JAK1(7), STAT1(5), STAT3(11), STAT5A(3), TNF(1)	5208279	56	45	55	36	30	4	5	8	9	0	0.663	1.000	1.000
519	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(6), ALDH3A1(10), ALDH3A2(3), ALDH9A1(3)	3395939	58	44	54	26	32	6	4	9	7	0	0.128	1.000	1.000
520	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(7), ALDH1A2(16), ALDH1A3(2), ALDH1B1(11), ALDH2(6), ALDH3A1(10), ALDH3A2(3), ALDH9A1(3)	3395939	58	44	54	26	32	6	4	9	7	0	0.128	1.000	1.000
521	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(12), CS(2), MDH1(3), ME1(22), PC(14), PDHA1(4), SLC25A11(4)	3974326	61	44	59	30	38	6	2	10	4	1	0.204	1.000	1.000
522	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	18	APAF1(6), BAK1(2), BAX(4), BCL2(3), BIK(2), BIRC2(6), BIRC3(7), CASP3(2), CASP7(4), CASP8(9), CASP9(2), CYCS(1), DFFA(2), DFFB(2), DIABLO(2)	5753598	54	44	53	20	26	6	6	6	10	0	0.289	1.000	1.000
523	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	ANP32A(3), CREBBP(24), DFFA(2), DFFB(2), GZMA(13), GZMB(3), HMGB2(2), NME1(1), PRF1(14), SET(3)	4524146	67	44	65	27	36	6	6	11	8	0	0.249	1.000	1.000
524	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNA1(1), IFNB1(6), IFNG(4), IL10(2), IL12A(4), IL12B(3), IL13(2), IL15(3), IL16(12), IL18(3), IL1A(5), IL2(4), IL3(3), IL4(1), IL5(4), IL6(2), IL9(1), LTA(5), TNF(1)	4210761	66	43	64	42	44	3	2	4	13	0	0.401	1.000	1.000
525	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(25), CKM(3), GPT(4), LDHA(5), LDHB(2), LDHC(7), MAPK14(5), NCL(6)	3838812	57	43	54	29	38	7	6	3	3	0	0.365	1.000	1.000
526	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(4), IFNG(4), IFNGR1(3), JAK1(7), JAK2(8), PLA2G2A(2), PTPRU(23), REG1A(8), STAT1(5)	4868210	64	43	63	28	36	6	1	6	15	0	0.195	1.000	1.000
527	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(9), CDKN1A(3), EPO(5), EPOR(1), GRIN1(8), HIF1A(4), JAK2(8), NFKB1(6), NFKBIA(2), RELA(4)	5348314	50	42	49	27	22	6	5	5	12	0	0.743	1.000	1.000
528	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(2), FOSL2(6), IFNAR1(3), IFNAR2(8), IFNB1(6), MAPK8(2), NFKB1(6), RELA(4), TNFRSF11A(5), TNFSF11(5), TRAF6(4)	4723058	51	42	50	32	35	3	0	8	5	0	0.871	1.000	1.000
529	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(2), LDLR(17), MBTPS1(9), MBTPS2(3), SCAP(12), SREBF1(5), SREBF2(10)	5067953	58	42	55	32	38	3	3	10	4	0	0.469	1.000	1.000
530	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(9), CYP2E1(14), NR1I3(6), PTGS1(20), PTGS2(13)	2299063	62	41	60	37	47	5	0	2	8	0	0.282	1.000	1.000
531	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(16), HK1(3), HK2(15), HK3(15), IMPA1(1), IMPA2(5), ISYNA1(1), PGM1(6), PGM3(1), TGDS(1)	4973149	64	41	62	43	45	5	1	7	6	0	0.633	1.000	1.000
532	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	BNIP1(4), GOSR1(2), GOSR2(2), SNAP25(7), SNAP29(2), STX10(1), STX11(3), STX12(1), STX16(2), STX17(1), STX19(2), STX2(2), STX3(2), STX4(1), STX5(4), STX6(2), TSNARE1(5), VAMP2(1), VAMP3(1), VAMP4(1), VAMP7(6), VAMP8(1), VTI1A(1), VTI1B(1)	7070200	55	41	53	29	31	4	2	9	9	0	0.393	1.000	1.000
533	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(5), CBS(7), CTH(1), GGT1(8), MARS(8), MARS2(4), MAT1A(6), MAT2B(2), PAPSS1(4), PAPSS2(5), SCLY(3), SEPHS1(2)	5313609	55	41	55	31	33	5	4	6	7	0	0.428	1.000	1.000
534	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(2), IL13RA1(4), IL13RA2(6), IL4R(18), JAK1(7), JAK2(8), TYK2(8)	4464580	53	41	53	26	36	2	2	7	6	0	0.466	1.000	1.000
535	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(2), IL13RA1(4), IL13RA2(6), IL4R(18), JAK1(7), JAK2(8), TYK2(8)	4464580	53	41	53	26	36	2	2	7	6	0	0.466	1.000	1.000
536	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CASP3(2), CD36(6), FOS(2), FYN(8), JUN(1), MAPK14(5), THBS1(31)	3160320	55	41	54	35	36	2	3	5	9	0	0.868	1.000	1.000
537	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(4), HS3ST1(11), HS3ST2(8), HS3ST3A1(6), HS3ST3B1(1), XYLT1(12), XYLT2(5)	2736347	47	40	47	42	31	5	1	6	4	0	0.885	1.000	1.000
538	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(4), HS3ST1(11), HS3ST2(8), HS3ST3A1(6), HS3ST3B1(1), XYLT1(12), XYLT2(5)	2736347	47	40	47	42	31	5	1	6	4	0	0.885	1.000	1.000
539	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(2), ALDH1B1(11), ALDH2(6), ALDH3A1(10), ALDH3A2(3), ALDH7A1(10), ALDH9A1(3), MIOX(5), UGDH(1)	3615161	51	40	49	27	27	6	6	5	7	0	0.366	1.000	1.000
540	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(3), CYP51A1(1), DHCR24(2), DHCR7(10), FDFT1(1), FDPS(3), GGCX(2), GGPS1(1), HMGCR(4), HSD17B7(1), IDI1(1), IDI2(1), LSS(4), MVD(1), MVK(2), NQO1(2), NSDHL(3), PMVK(2), SQLE(4), TM7SF2(5)	8219769	53	40	53	37	28	11	2	9	3	0	0.884	1.000	1.000
541	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(12), CAPN1(5), CAPNS1(2), CAPNS2(1), CDK5(6), CDK5R1(1), CSNK1A1(5), CSNK1D(3), GSK3B(3), MAPT(10), PPP2CA(1)	3844516	49	40	47	24	30	4	2	6	7	0	0.350	1.000	1.000
542	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(2), CD3D(7), CD3E(2), CD3G(1), IFNG(4), IL2(4), IL2RA(7), IL4(1), TGFB1(2), TGFB2(3), TGFB3(3), TGFBR2(9), TGFBR3(9), TOB1(3), TOB2(3)	4494803	60	40	60	31	45	3	1	1	10	0	0.287	1.000	1.000
543	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(2), DUSP1(1), IKBKAP(7), IKBKB(4), MAP3K1(4), NFKB1(6), NFKBIA(2), RELA(4), TNFAIP3(2), TRAF3(5), TRAF6(4)	7697587	41	39	41	33	25	6	1	4	5	0	0.979	1.000	1.000
544	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(4), PSMA2(1), PSMA4(4), PSMA5(3), PSMA6(5), PSMA7(1), PSMB1(1), PSMB2(2), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(2), PSMC2(2), PSMC3(4), PSMD1(6), PSMD12(2), PSMD13(3), PSMD2(4), PSMD6(1)	6878598	48	39	47	23	26	6	2	10	4	0	0.569	1.000	1.000
545	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(9), CD8A(2), CSF1(12), CSF2(2), CSF3(4), EPO(5), IL11(3), IL2(4), IL3(3), IL4(1), IL5(4), IL6(2), IL7(5), IL9(1)	2580061	57	39	55	37	38	2	1	6	10	0	0.374	1.000	1.000
546	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(16), GOT1(6), GOT2(6), TAT(21), TYR(11)	2008554	60	38	58	30	44	5	3	2	6	0	0.252	1.000	1.000
547	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(16), CCNE1(4), CDC34(4), CDK2(1), CUL1(3), E2F1(6), RB1(10), SKP2(2), TFDP1(2)	3635220	48	38	48	20	28	2	4	6	6	2	0.260	1.000	1.000
548	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(16), HK1(3), HK2(15), HK3(15), IMPA1(1), PGM1(6), PGM3(1), TGDS(1)	4367056	58	38	56	38	41	5	1	6	5	0	0.625	1.000	1.000
549	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(9), ALPL(11), ALPP(9), ALPPL2(12), DHFR(1), FPGS(3), GGH(4), SPR(4)	2730835	53	37	49	27	37	5	4	1	6	0	0.0732	1.000	1.000
550	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	6	ATM(16), ATR(22), CDC25C(5), CHEK1(2), CHEK2(2)	6462961	47	37	46	26	33	3	2	5	4	0	0.890	1.000	1.000
551	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(8), POLR2A(13), POLR2B(14), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(2), POLR2H(2), POLR2J(2), POLR2L(1), POLRMT(4)	5721949	49	37	47	27	27	5	2	11	4	0	0.664	1.000	1.000
552	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(7), JAK2(8), JAK3(11), MAPK1(4), MAPK3(3), STAT3(11), TYK2(8)	4971829	52	37	52	41	27	6	4	8	7	0	0.964	1.000	1.000
553	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(25), GNA12(3), PRKACB(4), PRKACG(10), PRKAG1(3), PRKAR2A(1), PRKAR2B(5)	4312019	51	36	51	32	32	4	1	8	6	0	0.845	1.000	1.000
554	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(1), ECHS1(3), HADH(3), HADHA(6), HADHB(6), HSD17B10(2), HSD17B4(6), MECR(5), PPT1(5), PPT2(4)	3623871	41	36	41	17	24	4	4	5	4	0	0.322	1.000	1.000
555	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(2), ASL(7), CPS1(29), GLS(2), GLUD1(2), GOT1(6)	3274065	48	36	45	23	31	4	2	9	2	0	0.486	1.000	1.000
556	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	AOC2(9), AOC3(9), CES1(21), ESD(3)	2570858	42	35	39	24	32	2	1	3	4	0	0.487	1.000	1.000
557	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(13), EIF2AK4(16), EIF2B5(3), EIF2S1(1), EIF2S3(2), EIF5(2), GSK3B(3), PPP1CA(3)	4952542	43	34	42	20	23	4	1	9	6	0	0.633	1.000	1.000
558	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNA1(1), IFNAR1(3), IFNAR2(8), IFNB1(6), JAK1(7), STAT1(5), STAT2(6), TYK2(8)	4609311	44	34	44	26	27	3	1	8	5	0	0.686	1.000	1.000
559	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CCNE1(4), CDC34(4), CDK2(1), CUL1(3), E2F1(6), FBXW7(11), RB1(10), TFDP1(2)	3483175	41	33	40	17	18	2	5	5	9	2	0.395	1.000	1.000
560	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(4), PSMA2(1), PSMA4(4), PSMA5(3), PSMA6(5), PSMA7(1), PSMB1(1), PSMB2(2), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(2), PSMC3(4), RPN2(4), UBE2A(1), UBE3A(6)	5529517	41	33	41	21	24	5	2	7	3	0	0.602	1.000	1.000
561	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAD(5), ALAS1(2), ALAS2(6), CPO(5), FECH(3), GATA1(4), HBA1(1), HBB(8), HMBS(1), UROS(1)	3298723	36	32	35	19	27	2	0	2	5	0	0.319	1.000	1.000
562	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(14), ENO1(4), GPI(3), HK1(3), PFKL(3), PGK1(3), PKLR(14), TPI1(1)	3925043	45	32	42	27	29	4	1	5	6	0	0.275	1.000	1.000
563	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	B3GALT1(15), B3GALT2(1), B3GALT5(1), B3GNT5(2), FUT1(4), FUT2(4), FUT3(8), ST3GAL3(2), ST3GAL4(1)	3064649	38	32	36	26	24	6	2	2	4	0	0.672	1.000	1.000
564	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	ALDOA(1), CTSD(4), ESR1(6), GREB1(21), HSPB1(2), HSPB2(1), MTA1(2), MTA3(2), PDZK1(3), TUBA8(5)	4570886	47	32	46	29	33	3	4	3	4	0	0.477	1.000	1.000
565	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(5), ADORA2A(3), ADORA2B(1), ADORA3(12), LTB4R(1), P2RY1(5), P2RY2(10), P2RY6(2)	2546495	39	32	38	34	23	6	2	4	4	0	0.428	1.000	1.000
566	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(7), CLOCK(4), CRY1(7), CRY2(7), CSNK1E(5), PER1(8)	3605154	38	31	37	24	25	5	1	3	4	0	0.867	1.000	1.000
567	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(6), ADSS(2), DHFR(1), IMPDH1(4), MTHFD2(2), POLB(1), POLD1(7), POLG(8), PRPS2(3), RRM1(3), SRM(1)	5315371	38	31	38	36	22	2	2	5	7	0	0.995	1.000	1.000
568	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	11	BFAR(1), CAMP(2), CREB5(9), MAPK1(4), RAF1(11), SNX13(5), SRC(2), TERF2IP(2)	4123067	36	31	34	30	25	3	1	4	3	0	0.976	1.000	1.000
569	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD28(2), CD4(9), CD80(4), HLA-DRA(13), HLA-DRB1(5), IL10(2), IL2(4), IL4(1)	1685448	40	30	38	22	28	0	0	6	5	1	0.230	1.000	1.000
570	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	CYP51A1(1), DHCR7(10), FDFT1(1), FDPS(3), HMGCR(4), HMGCS1(2), IDI1(1), LSS(4), MVD(1), MVK(2), NSDHL(3), PMVK(2), SQLE(4)	5613075	38	30	38	28	19	8	1	8	2	0	0.958	1.000	1.000
571	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS1(3), DHRS2(8), DHRS3(5), DHRS7(1), DHRSX(6), ESCO1(2), ESCO2(4), NAT6(5), PNPLA3(3), SH3GLB1(2)	7104319	39	30	39	27	23	3	4	6	3	0	0.960	1.000	1.000
572	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CDC25A(8), CDC25B(4), CDC25C(5), CSK(1), GRB2(2), PRKCA(9), PTPRA(9), SRC(2)	3961867	40	30	39	27	28	4	1	3	4	0	0.785	1.000	1.000
573	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(10), PLCG1(9), PRKCA(9), PTK2B(12)	2884962	40	29	38	33	29	3	1	2	5	0	0.751	1.000	1.000
574	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BAG4(3), BIRC3(7), CASP8(9), RIPK1(3), TNF(1), TNFRSF1A(4), TNFRSF1B(4), TRAF2(2)	3515682	33	29	33	16	22	1	2	3	5	0	0.416	1.000	1.000
575	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(10), FDFT1(1), FDPS(3), HMGCR(4), IDI1(1), LSS(4), MVD(1), MVK(2), NQO1(2), NQO2(1), PMVK(2), SQLE(4)	4698459	35	28	35	25	17	6	1	8	3	0	0.911	1.000	1.000
576	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	9	CASP3(2), CASP7(4), DFFA(2), DFFB(2), GZMB(3), HMGB1(1), HMGB2(2), TOP2A(11), TOP2B(9)	3787166	36	28	35	13	24	2	4	2	4	0	0.358	1.000	1.000
577	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	10	ACLY(12), ACO1(8), ACO2(5), ACSS1(2), ACSS2(4), FH(3), IDH2(2), MDH1(3), MDH2(4)	5343862	43	28	41	32	25	0	2	7	9	0	0.912	1.000	1.000
578	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(3), B4GALT1(2), B4GALT2(2), B4GALT3(3), B4GALT5(3), FUT8(8), ST3GAL1(8), ST3GAL2(1), ST3GAL3(2), ST3GAL4(1)	3358600	33	28	33	23	18	7	2	3	3	0	0.826	1.000	1.000
579	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(4), CDK2(1), CDKN1B(1), CUL1(3), E2F1(6), RB1(10), SKP2(2), TFDP1(2), UBE2M(1)	3665141	30	28	30	16	13	2	4	3	6	2	0.661	1.000	1.000
580	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	22	CDC34(4), NRF1(7), UBE2A(1), UBE2D1(1), UBE2D3(3), UBE2E1(1), UBE2E3(1), UBE2G2(1), UBE2H(1), UBE2I(2), UBE2J1(2), UBE2L3(1), UBE2L6(2), UBE2M(1), UBE2N(1), UBE2S(2), UBE3A(6)	4280909	37	28	37	20	23	4	2	4	4	0	0.743	1.000	1.000
581	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(6), ACAA2(1), ACAT2(1), ECHS1(3), EHHADH(6), HADHA(6), HADHB(6), SDS(3)	3568463	32	27	31	19	21	4	1	2	4	0	0.745	1.000	1.000
582	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT2(1), BDH1(5), HMGCL(4), HMGCS1(2), HMGCS2(18), OXCT1(4), OXCT2(5)	3051553	39	27	37	22	24	5	1	4	5	0	0.714	1.000	1.000
583	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	CCL2(3), CSF1(12), IL6(2), LDLR(17), LPL(6)	2287921	40	27	39	22	24	7	2	6	1	0	0.457	1.000	1.000
584	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CCL2(3), CSF1(12), IL1B(8), MST1R(10), TNF(1)	2797568	34	27	33	27	25	4	1	2	2	0	0.855	1.000	1.000
585	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	GRB2(2), HRAS(3), PTK2B(12), SHC1(2), SOS1(10), SRC(2)	3758030	31	26	31	29	20	3	0	6	2	0	0.997	1.000	1.000
586	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(1), RANBP2(25), RANGAP1(3)	3635217	29	26	28	13	20	2	1	1	5	0	0.681	1.000	1.000
587	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	FOS(2), JUN(1), KEAP1(2), MAFG(2), MAPK1(4), MAPK14(5), MAPK8(2), NFE2L2(4), PRKCA(9)	3783534	31	25	29	18	22	1	0	3	5	0	0.684	1.000	1.000
588	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(29), PDXK(1), PNPO(1), PSAT1(4)	2078451	35	25	33	23	27	1	2	4	1	0	0.801	1.000	1.000
589	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(4), PSMA2(1), PSMA4(4), PSMA5(3), PSMA6(5), PSMA7(1), PSMB1(1), PSMB10(2), PSMB2(2), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(2), PSMB8(4)	3756764	32	25	32	12	17	4	2	7	2	0	0.364	1.000	1.000
590	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	FUT1(4), FUT2(4), FUT3(8), FUT5(8), FUT6(4), ST3GAL3(2)	2140316	30	24	29	18	13	6	3	3	5	0	0.402	1.000	1.000
591	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(10), EPHX2(6), HSD3B7(5), RDH11(2), RDH12(2), RDH13(3), RDH14(1)	2057178	29	24	29	20	18	2	3	3	3	0	0.670	1.000	1.000
592	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(1), MTMR1(6), MTMR2(3), MTMR6(2), NFS1(4), TPK1(10)	2729917	26	24	26	12	16	1	2	2	5	0	0.658	1.000	1.000
593	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(7), APOBEC1(3), APOBEC2(5), APOBEC3A(2), APOBEC3B(2), APOBEC3C(2), APOBEC3F(4), APOBEC3G(3)	3153147	28	24	27	37	20	2	3	2	1	0	1.000	1.000	1.000
594	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNH(1), CDC25A(8), CDC25B(4), CDC25C(5), CDK7(2), MNAT1(2), SHH(3), XPO1(3)	3720288	28	24	28	13	17	3	3	4	1	0	0.552	1.000	1.000
595	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(2), ST3GAL1(8), ST3GAL2(1), ST3GAL4(1), ST3GAL5(3), ST6GALNAC2(3), ST6GALNAC4(4), ST8SIA1(1)	2421539	23	23	23	13	14	3	2	3	1	0	0.470	1.000	1.000
596	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(5), ALAS1(2), ALAS2(6), CPOX(4), FECH(3), HMBS(1), PPOX(3), UROS(1)	3228730	25	22	25	12	17	2	1	2	3	0	0.405	1.000	1.000
597	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(4), IFNGR1(3), IFNGR2(4), JAK1(7), JAK2(8), STAT1(5)	3480656	31	22	29	13	14	1	1	5	10	0	0.674	1.000	1.000
598	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(5), CS(2), FH(3), IDH2(2), MDH1(3), OGDH(9), SDHA(4)	4043724	28	22	28	23	17	0	2	6	3	0	0.952	1.000	1.000
599	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	ADAM17(1), DLL1(3), FURIN(7), NOTCH1(9), PSEN1(3)	3928050	23	22	23	21	12	4	2	4	1	0	0.941	1.000	1.000
600	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CCR5(10), CD28(2), CD3D(7), CD3E(2), CD3G(1), CD4(9)	1367799	31	22	30	23	22	2	0	3	4	0	0.631	1.000	1.000
601	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT2(1), ACYP1(1), ECHS1(3), EHHADH(6), GCDH(6), HADHA(6), SDS(3)	3331751	26	21	25	12	17	4	0	3	2	0	0.398	1.000	1.000
602	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	8	ACO1(8), ACO2(5), FH(3), IDH2(2), MDH1(3), MDH2(4)	3464572	25	21	23	17	14	0	2	3	6	0	0.829	1.000	1.000
603	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	11	ACTA1(4), ACTR2(3), ACTR3(2), ARPC1B(3), ARPC2(1), ARPC3(2), ARPC4(1), CDC42(2), WASF1(5), WASL(4)	3291311	27	21	27	14	15	4	2	4	2	0	0.681	1.000	1.000
604	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA10(4), NDUFA4(1), NDUFB2(3), NDUFB5(3), NDUFB6(2), NDUFB7(2), NDUFS1(2), NDUFS2(3), NDUFV1(1), NDUFV2(1)	2985660	22	21	22	13	13	1	1	6	1	0	0.865	1.000	1.000
605	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	ASRGL1(6), GBA(7), GGT1(8), SHMT1(2), SHMT2(3)	2292319	26	18	25	15	18	3	0	3	2	0	0.432	1.000	1.000
606	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	8	CHUK(2), DNAJC3(3), EIF2S1(1), NFKB1(6), NFKBIA(2), RELA(4)	3782875	18	18	18	9	10	3	1	2	2	0	0.595	1.000	1.000
607	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(4), GSTZ1(1), HGD(15)	956700	20	17	20	19	13	3	2	0	2	0	0.932	1.000	1.000
608	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(1), BCKDK(2), CBS(7), CTH(1), MUT(5)	2158481	16	16	16	10	11	2	1	1	1	0	0.703	1.000	1.000
609	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(4), RAB1A(2), RAB27A(3), RAB3A(4), RAB4A(2), RAB5A(2)	1797950	17	15	16	12	13	2	0	1	1	0	0.792	1.000	1.000
610	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(6), ARG1(2), GLS(2), GLUD1(2), OAT(4), PRODH(2)	2324817	18	14	18	17	5	5	3	3	2	0	0.987	1.000	1.000
611	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(1), PGLYRP2(19)	780976	20	13	19	14	14	2	1	2	1	0	0.756	1.000	1.000
612	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(4), IFNG(4), IL12A(4), IL12B(3), IL18(3), IL2(4)	1253962	22	13	21	10	14	2	0	1	5	0	0.317	1.000	1.000
613	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	ATP6V0C(1), GGT1(8), SHMT1(2), SHMT2(3)	1737524	14	11	14	15	9	2	0	2	1	0	0.930	1.000	1.000
614	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(4), HLCS(7)	1320714	11	11	11	11	7	0	1	2	1	0	0.936	1.000	1.000
615	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(1), FDPS(3), GGPS1(1), IDI1(1), IDI2(1), SQLE(4)	1813037	11	11	11	7	6	1	1	3	0	0	0.769	1.000	1.000
616	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(5)	909034	5	5	5	5	5	0	0	0	0	0	0.858	1.000	1.000
