rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	15	CDK2(1), CDKN1A(1), CDKN2A(2), MDM2(1), TP53(5)	401952	10	9	10	0	2	2	1	1	3	1	0.0874	8.20e-07	0.000297
2	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	7	ATM(5), ATR(1), CDC25C(1), CHEK1(1), CHEK2(2), TP53(5)	825226	15	12	15	0	2	6	2	1	3	1	0.0250	9.65e-07	0.000297
3	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	19	ATM(5), BRCA1(1), CDKN1A(1), CHEK1(1), CHEK2(2), MDM2(1), RAD50(1), TP53(5)	1482189	17	14	17	1	2	5	3	1	5	1	0.0762	1.26e-05	0.00259
4	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	16	APAF1(1), ATM(5), CDK2(1), CDKN1A(1), MDM2(1), TIMP3(1), TP53(5)	939238	15	11	15	1	1	5	1	1	6	1	0.118	2.57e-05	0.00330
5	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	16	CDKN2A(2), MDM2(1), PIK3CA(2), PIK3R1(2), TP53(5)	1017333	12	11	12	0	2	4	2	2	1	1	0.0417	2.68e-05	0.00330
6	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	19	ABCB1(1), ATM(5), CDKN1A(1), MDM2(1), TP53(5)	1064878	13	11	13	0	2	3	1	1	5	1	0.0469	6.67e-05	0.00684
7	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	22	ATM(5), ATR(1), BRCA1(1), CDC25C(1), CDKN1A(1), CHEK1(1), CHEK2(2), EP300(3), MDM2(1), PRKDC(2), TP53(5)	2178745	23	15	23	0	2	9	3	2	6	1	0.00339	0.000117	0.00948
8	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	12	ATM(5), CDC25C(1), CDK2(1), CHEK1(1), TP53(5)	903263	13	10	13	0	1	5	1	1	4	1	0.0379	0.000123	0.00948
9	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	30	ANPEP(1), GPX2(1), IDH1(4), IDH2(2), MGST1(1), PGD(2)	910815	11	11	8	1	5	4	0	1	1	0	0.0886	0.000251	0.0172
10	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	25	ATM(5), ATR(1), CDK2(1), CDKN1A(1), CDKN2A(2), TP53(5)	1539151	15	12	15	1	2	4	1	2	5	1	0.112	0.000396	0.0231
11	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	13	DAXX(2), PAX3(1), RARA(1), SP100(1), TP53(5)	906533	10	9	10	0	3	4	1	1	0	1	0.0574	0.000413	0.0231
12	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(1), ACO2(1), IDH1(4), IDH2(2)	448090	8	7	5	0	4	4	0	0	0	0	0.0605	0.000563	0.0289
13	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	20	APAF1(1), ATM(5), BAD(1), PRKCA(1), PTK2(1), STAT1(1), TLN1(1), TP53(5)	1337984	16	11	16	1	1	6	3	1	4	1	0.0742	0.00106	0.0485
14	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	7	TP53(5)	336111	5	5	5	0	1	2	1	0	0	1	0.284	0.00110	0.0485
15	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	65	ATM(5), CCNH(1), CDK2(1), CDKN1A(1), CDKN2A(2), CREB3L1(1), CREB3L4(1), MDM2(1), POLA2(1), POLE(5), POLE2(1), RBL1(1), TP53(5)	3857547	26	19	26	1	3	10	2	2	8	1	0.00755	0.00140	0.0576
16	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	21	ATM(5), ATR(1), BRCA1(1), BRCA2(3), CHEK1(1), CHEK2(2), FANCC(2), RAD1(1), RAD17(1), RAD50(1), TP53(5)	2233750	23	16	23	2	2	10	3	3	4	1	0.0640	0.00196	0.0753
17	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACO1(1), ACO2(1), ACSS2(1), IDH1(4), IDH2(2)	659079	9	8	6	1	4	5	0	0	0	0	0.149	0.00260	0.0941
18	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	110	ANAPC4(1), ATM(5), ATR(1), CCNA2(1), CCNB3(1), CCNH(1), CDC14A(1), CDC25C(1), CDC27(5), CDK2(1), CDKN1A(1), CDKN2A(2), CHEK1(1), CHEK2(2), EP300(3), ESPL1(1), MDM2(1), PRKDC(2), RBL1(1), RBL2(1), SMC1B(1), TP53(5)	6896774	39	23	39	1	6	15	6	3	8	1	0.000253	0.00301	0.103
19	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	GRB2(1), MAP2K1(1), PIK3CA(2), PIK3R1(2), PLCG1(1), PRKCA(1), RASA1(1), SOS1(1), STAT1(1), STAT5A(1), THPO(2)	1493290	14	12	14	1	1	7	2	2	2	0	0.0825	0.00316	0.103
20	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(1), ACO2(1), DLD(1), IDH1(4), IDH2(2), SDHA(1)	1035353	10	9	7	1	4	5	0	1	0	0	0.129	0.00353	0.105
21	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	BAD(1), GRB2(1), IGF1R(1), IRS1(2), MAP2K1(1), PIK3CA(2), PIK3R1(2), SOS1(1)	953052	11	9	11	1	1	7	1	2	0	0	0.149	0.00357	0.105
22	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	GRB2(1), NTRK1(1), PIK3CA(2), PIK3R1(2), PLCG1(1), PRKCA(1), SOS1(1)	773480	9	8	9	0	1	5	1	1	1	0	0.0712	0.00389	0.105
23	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	CDKN1A(1), ELK1(1), GRB2(1), MAP2K1(1), NTRK1(1), PIK3CA(2), SOS1(1)	827926	8	8	8	0	1	3	0	3	1	0	0.149	0.00393	0.105
24	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	9	DNAJC3(1), TP53(5)	493862	6	5	6	0	1	3	1	0	0	1	0.225	0.00474	0.120
25	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP2E1(1), NR1I3(2), PTGS1(1)	265148	4	4	4	0	0	0	2	0	2	0	0.461	0.00486	0.120
26	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	ELK1(1), GRB2(1), MAP2K1(1), PIK3CA(2), PIK3R1(2), PLCG1(1), SOS1(1)	942043	9	8	9	0	1	4	1	3	0	0	0.0937	0.00696	0.165
27	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(1), C7(1), ICAM1(1), ITGA4(2), ITGAL(1), ITGB1(1), SELP(1), SELPLG(1), VCAM1(1)	1263806	10	9	10	0	2	5	2	0	1	0	0.0406	0.00722	0.165
28	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	82	ATM(5), CCNA2(1), CCNB3(1), CCNH(1), CDAN1(1), CDC14A(1), CDC25C(1), CDH1(1), CDK2(1), CDKN1A(1), CDKN2A(2), CHEK1(1), CHEK2(2), EP300(3), ESPL1(1), HDAC4(2), HDAC5(1), HDAC6(1), MDM2(1), PRKDC(2), PTPRA(1), RBL1(1), TBC1D8(1), TP53(5)	5561337	38	19	38	1	7	12	5	4	9	1	0.000368	0.00786	0.167
29	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(5), CDC25C(1), CHEK1(1)	705636	7	6	7	0	0	3	0	1	3	0	0.165	0.00811	0.167
30	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	18	DNAJA3(1), IFNGR1(1), TP53(5)	905031	7	7	7	1	1	3	1	0	1	1	0.376	0.00816	0.167
31	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	65	APAF1(1), ATM(5), ATR(1), BAI1(2), CASP8(1), CCNB3(1), CDK2(1), CDKN1A(1), CDKN2A(2), CHEK1(1), CHEK2(2), DDB2(2), MDM2(1), PPM1D(1), PTEN(2), RFWD2(1), TP53(5), TSC2(2)	3295847	32	18	32	3	5	12	5	2	7	1	0.0220	0.0112	0.219
32	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	GRB2(1), HLA-DRA(1), ITK(1), PIK3CA(2), PIK3R1(2)	652159	7	6	7	0	2	3	1	1	0	0	0.137	0.0114	0.219
33	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	DGKA(2), ITGA9(2), ITPR1(1), ITPR2(5), ITPR3(2), MAP2K1(1), NR1I3(2), PDE3A(1), PDE3B(1), PIK3C2G(2), PIK3CA(2), PIK3R1(2)	2385481	23	14	23	2	3	9	3	6	1	1	0.0344	0.0123	0.230
34	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	ELK1(1), GRB2(1), IGF1R(1), IRS1(2), MAP2K1(1), PIK3CA(2), PIK3R1(2), RASA1(1), SOS1(1)	1252108	12	9	12	1	1	6	1	3	1	0	0.127	0.0129	0.234
35	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	36	ANPEP(1), GPX2(1), GSTK1(1), IDH1(4), IDH2(2), MGST1(1)	1117372	10	9	7	1	5	3	0	1	1	0	0.115	0.0137	0.241
36	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	39	AR(1), ESR2(1), NPM1(1), NR1I3(2), NR2C2(1), NR2E1(1), PPARA(1), PPARD(1), RARA(1), ROR1(1), RXRG(1)	1997712	12	12	12	1	6	2	1	0	3	0	0.0717	0.0166	0.284
37	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	APAF1(1), DAXX(2), MAPKAPK2(2)	542479	5	5	5	1	1	2	1	1	0	0	0.548	0.0201	0.335
38	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(1), ERBB4(3), PRKCA(1)	475782	5	5	5	0	0	3	0	1	1	0	0.259	0.0227	0.368
39	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	CAMK2B(1), CAMK2D(2), CAMK2G(1), GNAS(1), GRB2(1), PIK3CA(2), PIK3R1(2), PRKCA(1), SOS1(1)	1460950	12	10	12	0	3	6	1	1	1	0	0.0285	0.0250	0.394
40	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	ADAM17(1), APC(4), BTRC(2), DLL1(2), FZD1(1), NOTCH1(1)	1067103	11	8	11	1	2	4	0	0	5	0	0.150	0.0257	0.396
41	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA2(1), CDK2(1), CDKN2A(2)	437684	4	4	4	0	1	0	1	1	1	0	0.312	0.0288	0.426
42	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	GRIN1(1), GRIN2A(2), GRIN2D(3), NOS1(2), PRKCA(1), SYT1(1)	1242205	10	9	10	1	2	4	0	0	4	0	0.105	0.0291	0.426
43	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(4), CDH1(1), EP300(3), MAP2K1(1), TGFBR2(1)	1239317	10	8	10	1	1	3	1	3	2	0	0.319	0.0307	0.430
44	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	ELK1(1), GRB2(1), IRS1(2), MAP2K1(1), PIK3CA(2), PIK3R1(2), RASA1(1), SOS1(1)	1265076	11	8	11	0	1	5	1	3	1	0	0.0451	0.0310	0.430
45	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	ICAM1(1), ITGA4(2), ITGAL(1), ITGB1(1), SELL(2), SELP(1)	831847	8	6	8	0	0	4	3	0	1	0	0.101	0.0314	0.430
46	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	25	GRB2(1), IRS1(2), MAP2K1(1), PIK3CA(2), PIK3R1(2), PLCG1(1), PRKCA(1), SOS1(1), STAT5A(1)	1627762	12	10	12	0	1	7	1	2	1	0	0.0278	0.0350	0.459
47	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	ASNS(1), CA3(1), CA6(1), CA8(1), CA9(1), CPS1(1), HAL(1)	943582	7	7	7	1	1	5	1	0	0	0	0.330	0.0361	0.459
48	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	ICAM1(1), ITGA4(2), ITGAL(1), ITGB1(1), SELL(2)	630432	7	5	7	0	0	4	3	0	0	0	0.141	0.0363	0.459
49	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	24	ATM(5), DAZL(1), ESR2(1), MLH1(1), NCOR1(3), PTGER2(1)	1705702	12	10	12	1	1	4	3	1	3	0	0.130	0.0375	0.459
50	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(1), IDH2(2), SDHA(1)	471621	4	4	4	1	0	3	0	1	0	0	0.620	0.0381	0.459
51	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	HLA-DRA(1), IFNGR1(1), IL12B(1), IL12RB2(2)	638367	5	5	4	0	3	1	0	1	0	0	0.170	0.0386	0.459
52	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	ELK1(1), GRB2(1), MAP2K1(1), PIK3CA(2), PIK3R1(2), PLCG1(1), PRKCA(1), RASA1(1), SOS1(1), STAT1(1), STAT5A(1)	1763022	13	10	13	1	1	5	2	3	2	0	0.113	0.0387	0.459
53	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR2(1), PDE1B(2), PLCB1(1)	531336	4	4	4	0	2	0	1	1	0	0	0.324	0.0396	0.461
54	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	GRB2(1), MEF2B(1), NTRK1(1), PIK3CA(2), PIK3R1(2), PLCG1(1)	955209	8	7	8	1	2	4	1	1	0	0	0.257	0.0433	0.491
55	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	KEAP1(2), NFE2L2(1), PRKCA(1)	466273	4	4	4	0	0	1	0	1	2	0	0.445	0.0449	0.491
56	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1	CMBL(1)	26527	1	1	1	0	0	0	0	0	1	0	1.000	0.0452	0.491
57	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(1)	79242	1	1	1	0	0	0	0	1	0	0	0.852	0.0454	0.491
58	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CDC25C(1), GRB2(1), PRKCA(1), PTPRA(1)	466088	4	4	4	0	2	1	0	0	1	0	0.232	0.0471	0.500
59	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	PIK3CA(2), PIK3R1(2), PLCB1(1), PLCG1(1), PRKCA(1)	643353	7	5	7	0	0	3	2	1	1	0	0.152	0.0489	0.510
60	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	EGFR(1), ELK1(1), GRB2(1), MAP2K1(1), PIK3CA(2), PIK3R1(2), PLCG1(1), PRKCA(1), RASA1(1), SOS1(1), STAT1(1), STAT5A(1)	1889264	14	11	14	2	1	6	2	3	2	0	0.218	0.0502	0.515
61	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	26	BAD(1), GRB2(1), IRS1(2), JAK3(1), PIK3CA(2), PIK3R1(2), PPP1R13B(1), SOS1(1), STAT6(2)	1763106	13	10	13	1	2	8	1	2	0	0	0.0919	0.0513	0.518
62	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(1), HLA-A(1), ICAM1(1), ITGAL(1)	424262	4	4	4	0	0	1	2	1	0	0	0.381	0.0536	0.532
63	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	69	BAD(1), KDR(2), KRAS(2), MAP2K1(1), MAPK12(1), MAPKAPK2(2), NFATC2(1), NOS3(1), PIK3CA(2), PIK3CB(2), PIK3R1(2), PLA2G1B(1), PLCG1(1), PRKCA(1), PTK2(1), SPHK2(3)	3600573	24	17	24	2	3	9	6	3	3	0	0.0215	0.0567	0.554
64	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	ASNS(1), CA3(1), CA6(1), CA8(1), CA9(1), CPS1(1), HAL(1)	1056007	7	7	7	1	1	5	1	0	0	0	0.332	0.0596	0.562
65	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	BAD(1), ELK1(1), MAP2K1(1), PIK3CA(2), PIK3R1(2)	975254	7	6	7	0	0	3	1	3	0	0	0.182	0.0600	0.562
66	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	EIF4G1(3), EIF4G2(2), PIK3CA(2), PIK3R1(2), PTEN(2), TSC1(1), TSC2(2)	1386226	14	8	14	0	2	5	4	2	1	0	0.0260	0.0606	0.562
67	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	GAD1(2), HDC(1)	298337	3	3	3	0	0	2	0	0	1	0	0.329	0.0612	0.562
68	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	RPL10A(1), RPL36A(1), RPS10(1), RPS12(1), RPS21(1), RPS24(1), RPS28(1), RPS3(1)	1184982	8	7	8	0	1	4	1	1	1	0	0.0934	0.0646	0.585
69	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	PRMT3(2), PRMT7(1), WBSCR22(1)	697472	4	4	4	1	0	0	2	1	1	0	0.710	0.0663	0.591
70	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CSF1R(1), EGFR(1), GRB2(1), PRKCA(1), SH3GLB1(1), SH3KBP1(1)	969513	6	6	6	1	1	2	0	1	2	0	0.432	0.0672	0.591
71	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	HMGCL(2)	172085	2	2	2	0	1	1	0	0	0	0	0.557	0.0681	0.591
72	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(1), DDHD1(4), LIPA(1), SH3GLB1(1)	1245959	7	6	4	1	0	2	4	1	0	0	0.401	0.0702	0.601
73	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	PRMT3(2), PRMT7(1), WBSCR22(1)	714435	4	4	4	1	0	0	2	1	1	0	0.716	0.0722	0.607
74	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(2), BAIAP2(1), CASP1(1), CASP8(1), WWP1(1), WWP2(2)	1138313	8	7	8	1	1	2	3	1	1	0	0.299	0.0732	0.607
75	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	BAD(1), BRAF(1), GRB2(1), MAP2K1(1), MAP3K8(1), RPS6KA2(2), RPS6KA3(1), SOS1(1)	1467157	9	9	9	1	1	5	1	2	0	0	0.262	0.0755	0.607
76	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	GABRA1(1), GABRA2(1), GABRA4(2), GPHN(1), UBQLN1(1)	620953	6	5	6	0	0	3	1	0	2	0	0.170	0.0755	0.607
77	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(1), GABRA2(1), GABRA4(2)	414813	4	4	4	0	0	2	1	0	1	0	0.304	0.0759	0.607
78	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	GRB2(1), IARS(2), JAK3(1), PIK3CA(2), PPP1R13B(1), SOS1(1), STAT6(2), TYK2(2)	1842825	12	9	12	0	3	5	1	2	1	0	0.0385	0.0791	0.624
79	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC4(1), BTRC(2), CDC27(5), CUL2(1), FBXW7(1), SMURF1(1), WWP1(1), WWP2(2)	2063958	14	12	14	2	5	5	2	1	1	0	0.156	0.0806	0.628
80	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(1), POLE(5)	806541	6	6	6	0	0	5	0	0	1	0	0.132	0.0857	0.648
81	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CAMK1G(1), CAMK2B(1), CAMK2D(2), CAMK2G(1), SYT1(1)	576838	6	5	6	0	1	5	0	0	0	0	0.129	0.0858	0.648
82	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	CRKL(1), GRB2(1), MAP2K1(1), PIK3CA(2), PIK3R1(2), SOS1(1), STAT1(1), STAT5A(1)	1419872	10	8	10	1	1	5	2	2	0	0	0.215	0.0879	0.648
83	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	44	BRAF(1), PIK3CA(2), PIK3CB(2), PIK3R1(2), PRKAA2(1), RICTOR(1), RPS6KA2(2), RPS6KA3(1), STK11(1), TSC1(1), TSC2(2)	2665441	16	12	16	1	2	6	4	2	2	0	0.0838	0.0881	0.648
84	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(4), FBXW2(1), FOSL1(1), FZD1(1), FZD10(1), FZD5(1), FZD8(1), PAFAH1B1(1), PRKCA(1), PRKCD(1), PRKCI(1), PRKCQ(1), WNT10B(1), WNT5A(1)	2895818	17	13	17	3	2	6	2	1	6	0	0.198	0.0891	0.648
85	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	GRB2(1), PIK3CA(2), PTEN(2), RBL2(1), SOS1(1)	986439	7	6	7	0	1	3	1	1	1	0	0.187	0.0894	0.648
86	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	126	ARAF(2), BRAF(1), GRB2(1), HLA-A(1), HLA-B(5), ICAM1(1), IFNGR1(1), ITGAL(1), KRAS(2), MAP2K1(1), NFATC2(1), PIK3CA(2), PIK3CB(2), PIK3R1(2), PLCG1(1), PRKCA(1), SHC4(2), SOS1(1), TNFRSF10D(1), VAV3(1), ZAP70(1)	5683969	31	20	28	1	1	18	5	5	2	0	0.00100	0.0918	0.652
87	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(1), POLA2(1), POLB(1), POLE(5), POLE2(1), POLH(1), REV3L(2)	2083606	12	11	12	1	1	8	2	0	1	0	0.130	0.0925	0.652
88	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	ADAM17(1), DLL1(2), FURIN(1), NOTCH1(1)	459694	5	4	5	0	1	1	0	0	3	0	0.185	0.0951	0.652
89	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	42	APAF1(1), BIRC2(2), BIRC3(1), CASP8(1), MDM2(1), TP53(5)	1850606	11	10	11	2	1	5	2	1	1	1	0.386	0.0970	0.652
90	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AADAC(1), ALDH3A1(1), DDHD1(4), GAD1(2), HMGCL(2), RDH12(1)	2052644	11	10	8	2	1	3	4	2	1	0	0.367	0.0976	0.652
91	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(1), IL12B(1)	155526	2	2	2	0	0	1	0	1	0	0	0.646	0.0986	0.652
92	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	20	ELK1(1), GRB2(1), IL6ST(2), JAK3(1), MAP2K1(1), SOS1(1)	1205500	7	7	7	0	1	4	0	2	0	0	0.140	0.0990	0.652
93	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAD8(1), ADH6(1), AKR1C4(1), ALDH3A1(1), CEL(1), HADHB(1), LIPA(1), RDH12(1), SLC27A5(1), SOAT2(1)	1604808	10	8	10	1	1	4	0	3	2	0	0.209	0.0992	0.652
94	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCNH(1), CDK2(1), CDKN1A(1), CDKN2A(2), RBL1(1)	826293	6	5	6	0	2	1	0	1	2	0	0.219	0.0995	0.652
95	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	GOT1(1), TYR(1)	232850	2	2	2	0	2	0	0	0	0	0	0.484	0.108	0.693
96	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CR2(1), HLA-DRA(1), ICAM1(1), ITGAL(1), PTPRC(1)	782795	5	5	5	1	1	2	1	0	1	0	0.470	0.109	0.693
97	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(1), GNA12(1), PLCB1(1), PRKCA(1), ROCK1(2)	1051278	6	5	6	1	2	0	1	2	1	0	0.459	0.110	0.693
98	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	GRB2(1), IRS1(2), JAK3(1), STAT6(2)	734414	6	5	6	0	1	4	0	1	0	0	0.140	0.111	0.693
99	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	GPD2(1), SDHA(1)	318682	2	2	2	0	0	1	0	1	0	0	0.632	0.111	0.693
100	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	74	GRB2(1), KRAS(2), MAP2K1(1), MAPK12(1), PIK3CA(2), PIK3CB(2), PIK3R1(2), PLA2G1B(1), PLCG1(1), PRKCA(1), PRKCD(1), SOS1(1), VAV3(1)	3614642	17	13	17	0	1	7	3	3	3	0	0.00773	0.114	0.700
101	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	EGFR(1), GRB2(1), MAP2K1(1), RASA1(1), SOS1(1), SPRY1(1), SPRY4(1)	1257896	7	7	7	1	1	4	0	1	1	0	0.345	0.118	0.714
102	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTN2(1), CAPN1(1), CAV1(1), CRKL(1), GRB2(1), ITGB1(1), MAP2K1(1), PTK2(1), ROCK1(2), SOS1(1), TLN1(1), ZYX(2)	2371056	14	12	14	2	2	6	3	3	0	0	0.187	0.118	0.714
103	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(1), ITGB1(1), MAP2K1(1), PIK3CA(2), PIK3R1(2), PTK2(1), ROCK1(2), TLN1(1)	1849335	11	8	11	1	1	4	2	4	0	0	0.203	0.120	0.719
104	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	MAP2K1(1), PIK3C2G(2), PIK3CA(2), PIK3R1(2), PLCG1(1), PRKCA(1), PTK2(1)	1395401	10	7	10	0	0	5	2	2	1	0	0.0649	0.122	0.719
105	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	34	BAD(1), CRKL(1), GRB2(1), IRS1(2), JAK3(1), PIK3CA(2), PIK3R1(2), SOS1(1), STAT5A(1)	1827290	12	10	12	0	1	9	1	1	0	0	0.0226	0.122	0.719
106	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	ELK1(1), GRB2(1), MAP2K1(1), NFATC2(1), PIK3CA(2), PIK3R1(2), PLCG1(1), PRKCA(1), RASA1(1), SOS1(1), SYT1(1), ZAP70(1)	2360869	14	11	14	2	1	6	2	3	2	0	0.196	0.125	0.724
107	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	62	BAD(1), CDK2(1), CDKN2A(2), ERBB4(3), GRB2(1), INPPL1(1), IRS1(2), NOLC1(1), PARD3(1), PIK3CA(2), PPP1R13B(1), PTEN(2), PTK2(1), RPS6KA2(2), RPS6KA3(1), SOS1(1), TSC1(1), TSC2(2)	3731102	26	17	26	3	6	10	5	3	2	0	0.0458	0.127	0.727
108	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ADH6(1), AKR1C4(1), ALDH3A1(1), CEL(1), HADHB(1), SOAT2(1)	1155003	6	6	6	0	1	2	0	1	2	0	0.165	0.128	0.727
109	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	BAD(1), CDKN2A(2), GRB2(1), IARS(2), PIK3CA(2), PPP1R13B(1), PTEN(2), RPS6KA2(2), RPS6KA3(1), SOS1(1)	1770496	15	10	15	2	4	6	2	2	1	0	0.194	0.129	0.727
110	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP2(1), CMBL(1), CYP3A43(2), CYP3A5(2)	899206	6	5	6	1	1	2	0	0	2	1	0.689	0.130	0.727
111	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	SRP54(1), SRPR(3)	381939	4	3	4	0	1	1	2	0	0	0	0.305	0.135	0.736
112	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	ITGB1(1), MAP2K1(1), PLCB1(1), PRKCA(1), PTGS1(1), PTK2(1)	1213728	6	6	6	0	0	1	3	1	1	0	0.217	0.135	0.736
113	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	GNA12(1), PIK3CA(2), PIK3R1(2), PLCB1(1), PRKCA(1), ROCK1(2)	1289037	9	6	9	0	1	2	2	3	1	0	0.102	0.135	0.736
114	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	42	BRAF(1), CRKL(1), EGR4(1), ELK1(1), MAP1B(2), NTRK1(1), PIK3C2G(2), PIK3CA(2), PIK3R1(2), RPS6KA3(1)	2539419	14	11	14	1	1	6	2	3	2	0	0.0812	0.138	0.740
115	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	ETV5(1), IL12B(1), IL12RB2(2), TYK2(2)	944974	6	5	5	0	3	0	1	1	1	0	0.201	0.138	0.740
116	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CAMK1G(1), CAMK2B(1), CAMK2D(2), CAMK2G(1), HDAC5(1), MEF2B(1), PPARA(1), SYT1(1)	1027468	9	8	9	2	2	6	0	0	1	0	0.330	0.140	0.742
117	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	DNMT1(1), PTGER2(1), PTGER4(1), TBXA2R(1)	489162	4	4	4	0	3	0	1	0	0	0	0.240	0.143	0.747
118	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	SLPI(1)	73088	1	1	1	0	0	1	0	0	0	0	0.733	0.143	0.747
119	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCR1(1), IFNGR1(1), IL12B(1), IL12RB2(2)	967313	5	5	4	0	2	1	1	1	0	0	0.201	0.145	0.749
120	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	ELK1(1), GRB2(1), MAP2K1(1), PLCG1(1), SOS1(1), STAT5A(1)	1084848	6	6	6	0	1	3	0	2	0	0	0.181	0.147	0.755
121	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	58	CAD(3), CASP8(1), DAXX(2), EGFR(1), FAIM2(1), NFKB2(2), PTPN13(1), ROCK1(2), TP53(5)	3637516	18	12	18	2	2	8	2	3	2	1	0.112	0.149	0.757
122	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ARPC2(1), PIK3CA(2), PIK3R1(2)	687653	5	4	5	0	0	3	1	1	0	0	0.288	0.152	0.766
123	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	ICAM1(1), ITGAL(1), SELL(2)	541283	4	3	4	0	0	1	3	0	0	0	0.364	0.161	0.788
124	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	19	APAF1(1), BIRC2(2), BIRC3(1), CASP8(1)	671304	5	4	5	1	0	3	1	1	0	0	0.589	0.161	0.788
125	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	BAD(1), PIK3CA(2), PIK3R1(2)	700319	5	4	5	0	0	3	1	1	0	0	0.275	0.163	0.788
126	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	GNAS(1), NOS3(1), PIK3CA(2), PIK3R1(2), SYT1(1)	906092	7	5	7	1	1	4	1	1	0	0	0.380	0.163	0.788
127	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	GAD1(2)	294882	2	2	2	0	0	1	0	0	1	0	0.508	0.163	0.788
128	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(1), ACO2(1), HAO1(1), MTHFD2(1)	640747	4	4	4	0	1	2	0	1	0	0	0.293	0.164	0.788
129	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	12	IGF1R(1), PIK3CA(2), PIK3R1(2)	663361	5	4	5	1	0	3	1	1	0	0	0.543	0.165	0.789
130	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(1), ARHGAP5(1), CASP1(1), CASP8(1)	642034	4	4	4	1	1	3	0	0	0	0	0.622	0.169	0.794
131	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1G(1), HDAC9(1), MEF2B(1)	425589	3	3	3	1	1	2	0	0	0	0	0.682	0.169	0.794
132	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	EIF4G1(3), EIF4G2(2), IRS1(2), PIK3CA(2), PIK3R1(2), PRKCA(1), PTEN(2)	1415565	14	7	14	0	0	7	3	2	2	0	0.0318	0.170	0.794
133	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(2), GNA12(1)	487175	3	3	3	0	1	2	0	0	0	0	0.394	0.173	0.800
134	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(2), CSF1R(1), ETS1(2), HDAC5(1), RBL1(1), RBL2(1)	1312599	8	7	8	1	4	3	0	0	1	0	0.202	0.176	0.806
135	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	IL12B(1), IL12RB2(2), TYK2(2)	741392	5	4	4	0	2	0	1	1	1	0	0.296	0.177	0.806
136	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	28	BIRC2(2), BIRC3(1), CASP8(1), NFKB2(2), NR2C2(1)	1373936	7	7	7	1	1	3	1	1	1	0	0.334	0.179	0.811
137	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	HLA-DRA(1)	123142	1	1	1	0	1	0	0	0	0	0	0.675	0.181	0.813
138	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	GRB2(1), ITGB1(1), PIK3CA(2), PIK3R1(2), PTEN(2), PTK2(1), SOS1(1)	986879	10	5	10	0	1	4	3	1	1	0	0.0824	0.182	0.814
139	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	23	APC(4), BTRC(2), FZD1(1), PPARD(1), TLE1(1)	1478792	9	7	9	1	3	3	0	0	3	0	0.223	0.184	0.814
140	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(1), ACO2(1), HAO1(1), MTHFD2(1)	673095	4	4	4	0	1	2	0	1	0	0	0.291	0.186	0.820
141	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNH(1), CDC25C(1), XPO1(1)	448163	3	3	3	0	0	3	0	0	0	0	0.449	0.190	0.822
142	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	CRKL(1), GRB2(1), MAP2K1(1), PLCG1(1), PRKCA(1), SOS1(1), SYT1(1)	1426211	7	7	7	1	1	4	0	1	1	0	0.330	0.191	0.822
143	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	ICAM1(1), ITGAL(1), PTPRC(1)	534068	3	3	3	0	0	1	1	0	1	0	0.399	0.191	0.822
144	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	GART(1), MTFMT(2), MTHFD2(1), MTR(1)	928698	5	4	5	0	0	2	1	2	0	0	0.287	0.193	0.824
145	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	HLA-DRA(1), PTPRC(1), ZAP70(1)	460267	3	3	3	0	1	1	0	0	1	0	0.356	0.194	0.824
146	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	PLCG1(1), PRKCA(1)	295522	2	2	2	0	0	1	0	0	1	0	0.459	0.196	0.825
147	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	ELK1(1), GRB2(1), JAK3(1), MAP2K1(1), SOS1(1), STAT5A(1)	1187057	6	6	6	0	1	3	0	2	0	0	0.174	0.197	0.826
148	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	ACHE(1), GAD1(2), HDC(1)	720263	4	4	4	0	1	2	0	0	1	0	0.224	0.207	0.860
149	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	ICAM1(1), ITGAL(1), PTPRC(1)	564987	3	3	3	0	0	1	1	0	1	0	0.399	0.212	0.875
150	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	PRMT3(2), PRMT7(1), SCLY(2), WBSCR22(1)	1253540	6	5	6	1	0	2	2	1	1	0	0.481	0.218	0.895
151	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CSF1(2), HLA-DRA(1), IL12B(1)	677132	4	4	4	0	2	1	0	1	0	0	0.259	0.222	0.901
152	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(2), DGKI(1), IL6ST(2), RPS10(1), RPS12(1), RPS21(1), RPS24(1), RPS28(1), RPS3(1), RPS6KA2(2), RPS6KA3(1)	2698129	14	10	14	1	1	8	3	1	1	0	0.0930	0.224	0.901
153	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	26	APC(4), FZD1(1), GJA1(1), PIK3CA(2), PIK3R1(2)	1507951	10	9	10	2	1	5	1	1	2	0	0.432	0.224	0.901
154	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	HLA-DRA(1)	149413	1	1	1	0	1	0	0	0	0	0	0.675	0.227	0.901
155	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	GNAS(1), MAP2K1(1), PIK3C2G(2), PLCB1(1), PRKCA(1), PTK2(1)	1304031	7	6	7	0	1	2	2	1	1	0	0.155	0.228	0.901
156	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	PLCB1(1), PRKCA(1)	404032	2	2	2	0	0	0	1	0	1	0	0.570	0.228	0.901
157	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	85	ARAF(2), BAD(1), BRAF(1), CAMK2B(1), CAMK2D(2), CAMK2G(1), CDKN1A(1), CRKL(1), EGFR(1), ELK1(1), ERBB2(2), ERBB4(3), GRB2(1), KRAS(2), MAP2K1(1), PIK3CA(2), PIK3CB(2), PIK3R1(2), PLCG1(1), PRKCA(1), PTK2(1), SHC4(2), SOS1(1), STAT5A(1)	5223527	34	19	33	3	2	19	5	6	2	0	0.0113	0.233	0.909
158	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	70	ACACB(1), ACSL3(1), ACSL5(1), ACSL6(1), CD36(1), CPT1C(1), IRS1(2), JAK3(1), NFKB2(2), PPARA(1), PRKAA2(1), PRKCQ(1), RXRG(1), STK11(1), TYK2(2)	4067249	18	15	18	1	2	8	3	0	5	0	0.0458	0.234	0.909
159	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	CSF1(2)	261188	2	2	2	1	1	1	0	0	0	0	0.810	0.235	0.909
160	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA5(2), UBE3A(1)	669474	3	3	3	0	0	0	0	0	3	0	0.564	0.236	0.909
161	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ALDH3A1(1), CNDP1(1), GAD1(2), SMS(1)	1351655	5	5	5	0	0	1	0	1	3	0	0.269	0.238	0.909
162	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2A1L(1), GTF2I(1), GTF2IRD1(1), TAF1L(2), TAF2(1), TAF6(1), TBPL2(1)	1826706	8	7	8	1	1	4	2	0	1	0	0.317	0.240	0.913
163	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	82	APAF1(1), ATM(5), BAD(1), BIRC2(2), BIRC3(1), CAPN1(1), CASP8(1), NFKB2(2), NTRK1(1), PIK3CA(2), PIK3CB(2), PIK3R1(2), TNFRSF10D(1), TP53(5)	4185661	27	17	27	3	1	12	6	3	4	1	0.0515	0.244	0.920
164	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ALDH3A1(1), CNDP1(1), HAL(1), HDC(1), MAOB(1), PRPS1(1)	1222363	6	5	6	1	1	3	0	1	1	0	0.412	0.245	0.920
165	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(1)	131636	1	1	1	0	1	0	0	0	0	0	0.709	0.248	0.922
166	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(1)	179603	1	1	1	0	1	0	0	0	0	0	0.724	0.253	0.922
167	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	GLB1(1), HEXA(1), MANBA(1), NEU4(1)	806591	4	4	4	0	2	1	0	0	1	0	0.238	0.262	0.922
168	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1S(1), C2(1), C3(1), C7(1)	880265	4	4	4	0	1	2	1	0	0	0	0.287	0.264	0.922
169	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(2), NFATC2(1)	592558	3	3	3	0	1	1	1	0	0	0	0.365	0.264	0.922
170	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	HMGCL(2)	353106	2	2	2	1	1	1	0	0	0	0	0.859	0.265	0.922
171	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AASS(1), ALDH3A1(1), DOT1L(2), EHMT2(1), GCDH(1), PLOD1(1), PLOD2(1)	1818753	8	7	8	1	1	4	1	1	1	0	0.271	0.268	0.922
172	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	15	EGFR(1), IGF1R(1), PRKCA(1), TP53(5)	1375440	8	6	8	2	1	4	1	0	1	1	0.502	0.268	0.922
173	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARFGEF2(1), COPA(1), GBF1(3), GPLD1(1)	816391	6	5	6	2	1	4	0	0	1	0	0.590	0.268	0.922
174	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	B2M(1), CIITA(1), CTSB(1), HLA-A(1), HLA-B(5), HLA-DMA(1), HLA-DOA(1), HLA-DQA1(1), HLA-DRA(1), HSP90AB1(1), NFYB(1), TAP1(2)	2347590	17	12	15	3	1	10	3	2	1	0	0.186	0.268	0.922
175	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	COX15(1), CP(1), EPRS(1), FTH1(3), GUSB(1), UGT1A9(1), UGT2B15(2), UGT2B17(1), UROD(1)	2106668	12	10	10	2	1	6	2	1	2	0	0.397	0.272	0.922
176	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	LPO(1), PRDX1(1), TYR(1)	478918	3	3	3	0	1	1	0	0	1	0	0.480	0.272	0.922
177	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	ALDH3A1(1), GAD1(2), HMGCL(2)	1281811	5	5	5	0	1	2	0	1	1	0	0.221	0.274	0.922
178	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	CPS1(1), GOT1(1)	398939	2	2	2	1	1	1	0	0	0	0	0.827	0.274	0.922
179	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	B2M(1), HLA-A(1), ITGB1(1), MAP2K1(1), PIK3CA(2), PIK3R1(2)	967759	8	4	8	0	0	3	2	3	0	0	0.150	0.275	0.922
180	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	MAP2K1(1), PIK3CA(2), PIK3R1(2)	996889	5	4	5	1	0	2	1	2	0	0	0.617	0.277	0.922
181	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	BAD(1), GRB2(1), MAP2K1(1), NFKB2(2), PIK3CA(2), PIK3R1(2), PPP1R13B(1), SOS1(1)	2599811	11	10	11	0	2	5	1	2	1	0	0.0367	0.277	0.922
182	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA5(2)	446417	2	2	2	1	0	0	0	0	2	0	0.847	0.278	0.922
183	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	MAP2K1(1), PLCB1(1), PRKCA(1)	751799	3	3	3	1	0	0	1	1	1	0	0.768	0.280	0.922
184	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	22	BAD(1), IGF1R(1), KIT(1), PIK3CA(2), PIK3R1(2)	1094408	7	5	7	1	1	4	1	1	0	0	0.324	0.280	0.922
185	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	RDH12(1)	243022	1	1	1	0	0	0	0	1	0	0	0.836	0.280	0.922
186	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	ALOX15(1), CYP2E1(1), CYP3A43(2), CYP3A5(2), PLA2G1B(1), RDH12(1)	1249668	8	5	8	1	0	4	0	1	2	1	0.512	0.282	0.922
187	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	57	ASH1L(1), ASH2L(1), CTCFL(1), DOT1L(2), EHMT2(1), EZH2(1), HSF4(2), JMJD4(1), NSD1(1), PAXIP1(4), PPP1CB(1), PRDM6(1), PRDM9(3), PRMT7(1), SATB1(1), SETD1B(2), SETD2(2), SETD7(1), SETD8(1), WHSC1(1), WHSC1L1(2)	6274985	31	19	31	2	4	14	5	0	7	1	0.0101	0.283	0.922
188	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	HLA-DRA(1)	205430	1	1	1	0	1	0	0	0	0	0	0.677	0.283	0.922
189	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ALDH3A1(1), CNDP1(1), GAD1(2), SMS(1)	1451644	5	5	5	0	0	1	0	1	3	0	0.272	0.284	0.922
190	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACO1(1), ACO2(1), DLD(1), IDH1(4), IDH2(2), OGDHL(1), SDHA(1)	1474167	11	10	8	3	4	6	0	1	0	0	0.391	0.285	0.922
191	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CSF1(2)	314405	2	2	2	0	1	1	0	0	0	0	0.444	0.286	0.922
192	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F5(1), F7(1), FGB(1), PROS1(1)	820796	4	4	4	1	1	2	0	0	1	0	0.550	0.289	0.927
193	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	APC(4), ITPR1(1), ITPR2(5), ITPR3(2), KCNJ5(1), KCNJ9(1), RYR1(3)	2236638	17	12	17	3	5	4	1	4	2	1	0.203	0.292	0.931
194	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	ASNS(1), CAD(3), CRAT(1), GAD1(2), GOT1(1)	1286285	8	7	8	2	2	4	1	0	1	0	0.435	0.301	0.955
195	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CSF1(2)	293022	2	2	2	0	1	1	0	0	0	0	0.471	0.302	0.955
196	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	FSHB(1), GNAS(1), XPO1(1)	483065	3	3	3	0	1	1	1	0	0	0	0.442	0.308	0.967
197	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	DHCR24(1), HSD17B7(1), MVD(2)	959087	4	4	4	0	3	1	0	0	0	0	0.236	0.309	0.967
198	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP2(1), TYR(1)	498380	2	2	2	0	2	0	0	0	0	0	0.493	0.312	0.969
199	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	DNMT1(1), MTFMT(2), MTR(1)	1042928	4	4	4	0	1	1	1	1	0	0	0.322	0.317	0.980
200	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	CAD(3), CPS1(1), EPRS(1), GAD1(2), GOT1(1)	1645169	8	7	8	2	2	3	1	1	1	0	0.504	0.319	0.981
201	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	DCXR(1), GUSB(1), UGT1A9(1), UGT2B15(2)	908559	5	4	5	1	0	2	1	0	2	0	0.742	0.332	1.000
202	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	GRB2(1), MAP2K1(1), SOS1(1), STAT5A(1)	901587	4	4	4	0	1	2	0	1	0	0	0.298	0.333	1.000
203	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CDK2(1), CKS1B(1)	445081	2	2	2	1	0	0	0	1	1	0	0.897	0.334	1.000
204	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	IGF1R(1), INPPL1(1), PIK3CA(2), PIK3R1(2), PTEN(2)	1010838	8	4	8	1	1	3	2	1	1	0	0.364	0.335	1.000
205	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	4	GRIA2(1)	181651	1	1	1	0	1	0	0	0	0	0	0.627	0.335	1.000
206	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	35	CRKL(1), DOCK1(1), ELK1(1), GRB2(1), ITGB1(1), MAP2K1(1), PIK3CA(2), PIK3R1(2), PTEN(2), PTK2(1), RASA1(1), SOS1(1)	2322567	15	8	15	0	1	6	3	3	2	0	0.0216	0.336	1.000
207	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ADH6(1), ALDH3A1(1), AOX1(2), DCT(1), FAH(1), GOT1(1), MAOB(1), PRMT3(2), PRMT7(1), SH3GLB1(1), TYR(1), WBSCR22(1)	2957761	14	11	14	2	3	1	4	3	3	0	0.229	0.338	1.000
208	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	CASP8(1)	182251	1	1	1	0	0	1	0	0	0	0	0.727	0.340	1.000
209	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH6(1), ALDH3A1(1), CEL(1), DAK(1), DGAT1(1), DGKA(2), DGKB(1), DGKI(1), GK2(1), GLB1(1), LIPA(1), LIPC(1), LIPF(1), PPAP2A(1)	2972742	15	11	15	1	1	7	5	1	1	0	0.0606	0.343	1.000
210	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP5O(1), ATP6V1G1(1), FDXR(2)	800400	4	4	4	0	0	3	0	1	0	0	0.309	0.344	1.000
211	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	PRKCA(1)	240611	1	1	1	0	0	0	0	0	1	0	0.665	0.345	1.000
212	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	CSF1(2), SELL(2)	678137	4	3	4	0	1	1	2	0	0	0	0.293	0.351	1.000
213	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	GRB2(1), SOS1(1)	426757	2	2	2	0	1	1	0	0	0	0	0.506	0.353	1.000
214	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	EP300(3), JAK3(1), PIK3CA(2), PIK3R1(2), STAT5A(1)	1355389	9	6	9	0	0	6	1	2	0	0	0.0861	0.354	1.000
215	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	UXS1(1)	198108	1	1	1	0	1	0	0	0	0	0	0.687	0.355	1.000
216	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(1)	109706	1	1	1	0	0	0	1	0	0	0	0.794	0.355	1.000
217	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(1), PLA2G1B(1)	527645	2	2	2	0	0	1	0	1	0	0	0.592	0.361	1.000
218	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	STX3(2), TSNARE1(2), VAMP5(1)	863925	5	4	5	1	0	2	0	1	2	0	0.559	0.362	1.000
219	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP4(1), BMP5(1), BMP6(1), BTRC(2), CSNK1A1L(1), DHH(1), GLI2(1), LRP2(2), PRKX(1), PTCH1(2), PTCH2(1), STK36(2), WNT10B(1), WNT3A(1), WNT5A(1), WNT9A(1)	2898082	20	13	20	3	1	11	2	2	4	0	0.0840	0.363	1.000
220	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ALDH3A1(1), GOT1(1), LPO(1), MAOB(1), PRDX1(1)	1115622	5	5	5	0	1	2	0	1	1	0	0.265	0.364	1.000
221	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	PER1(3), PER2(1), PER3(1)	810338	5	4	5	1	0	2	3	0	0	0	0.536	0.364	1.000
222	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA5(2), PSMD2(1)	820469	3	3	3	0	0	0	0	0	3	0	0.567	0.365	1.000
223	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1S(1), C2(1), C3(1), C7(1)	1034533	4	4	4	1	1	2	1	0	0	0	0.595	0.366	1.000
224	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	IARS(2)	508591	2	2	2	1	1	1	0	0	0	0	0.868	0.368	1.000
225	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	HLA-DRA(1)	264969	1	1	1	0	1	0	0	0	0	0	0.656	0.368	1.000
226	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	ITGAV(1), PIK3CA(2), PIK3R1(2), PLCB1(1), PRKCA(1), PTK2(1)	1341648	8	5	8	0	0	3	3	1	1	0	0.113	0.370	1.000
227	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ALDH3A1(1), CNDP1(1), HAL(1), HDC(1), MAOB(1), PRMT3(2), PRMT7(1), PRPS1(1), WBSCR22(1)	1992353	10	9	10	3	1	3	2	2	2	0	0.587	0.371	1.000
228	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	48	CAP1(1), CDKN2A(2), GRB2(1), INPPL1(1), IRS1(2), PARD3(1), PIK3CA(2), PIK3R1(2), PTEN(2), RPS6KA2(2), RPS6KA3(1), SORBS1(2), SOS1(1)	2829877	20	12	20	3	3	8	5	3	1	0	0.172	0.373	1.000
229	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	69	ADH6(1), AKR1C4(1), ALDH3A1(1), CYP2E1(1), CYP2S1(1), CYP3A43(2), CYP3A5(2), DHDH(1), GSTK1(1), MGST1(1), UGT1A9(1), UGT2B15(2), UGT2B17(1)	2972599	16	11	16	3	3	4	1	1	6	1	0.410	0.378	1.000
230	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(1), IL22RA1(1), JAK3(1), STAT1(1), STAT5A(1), TYK2(2)	943108	7	5	7	0	0	4	2	0	1	0	0.157	0.378	1.000
231	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1S(1), C2(1), C3(1), C7(1)	1056695	4	4	4	0	1	2	1	0	0	0	0.284	0.380	1.000
232	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(1), C7(1)	644828	2	2	2	0	1	0	1	0	0	0	0.519	0.383	1.000
233	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ADH6(1), ALDH3A1(1), AOX1(2), DCT(1), FAH(1), GOT1(1), MAOB(1), TYR(1)	1620405	9	6	9	0	3	1	2	1	2	0	0.0720	0.386	1.000
234	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDKN1A(1), CHEK1(1)	395625	2	2	2	0	0	1	0	0	1	0	0.783	0.387	1.000
235	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	17	CDKN1A(1), NFATC2(1), PLCG1(1), PRKCA(1), SYT1(1)	981950	5	4	5	1	0	2	1	0	2	0	0.591	0.390	1.000
236	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	MVD(2)	563412	2	2	2	0	2	0	0	0	0	0	0.452	0.393	1.000
237	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	DCXR(1), GUSB(1), UGT1A9(1), UGT2B15(2), UGT2B17(1), XYLB(1)	1399383	7	5	7	1	1	2	2	0	2	0	0.515	0.394	1.000
238	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AASS(1)	247784	1	1	1	1	0	1	0	0	0	0	0.951	0.398	1.000
239	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	GART(1), MTHFD2(1), MTR(1)	872324	3	3	3	0	0	1	0	2	0	0	0.512	0.398	1.000
240	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	38	DLD(1), MAP3K11(1), MAP3K13(1), MAP3K2(1), NR2C2(1), TP53(5)	2489627	10	10	10	2	3	3	2	1	0	1	0.418	0.401	1.000
241	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	THTPA(1)	323345	1	1	1	0	0	0	1	0	0	0	0.754	0.404	1.000
242	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	PLCG1(1), PRKCA(1), SYT1(1)	656640	3	3	3	0	0	2	0	0	1	0	0.352	0.405	1.000
243	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	33	MAPK12(1), NFKB2(2), PIK3CA(2), PIK3R1(2), SYT1(1), TRAF5(1)	1686287	9	6	9	0	0	4	1	1	3	0	0.0597	0.405	1.000
244	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK3(1), TYK2(2)	607368	3	3	3	0	0	1	1	0	1	0	0.564	0.405	1.000
245	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	GNAS(1), PRKCA(1)	483678	2	2	2	0	1	0	0	0	1	0	0.538	0.411	1.000
246	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	67	APAF1(1), BAD(1), BIRC2(2), BIRC3(1), CASP1(1), CASP8(1), IRF6(2), MDM2(1), TNFRSF21(1), TP53(5)	2761388	16	12	16	3	1	7	5	1	1	1	0.304	0.419	1.000
247	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	UXS1(1)	252494	1	1	1	0	1	0	0	0	0	0	0.690	0.420	1.000
248	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	GLB1(1), HEXA(1), MANBA(1), NEU4(1)	981392	4	4	4	0	2	1	0	0	1	0	0.229	0.424	1.000
249	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	ALOX15(1), CYP4F3(1), LPO(1), PLA2G1B(1), PRDX1(1), PTGS1(1)	1415699	6	6	6	1	1	3	1	0	1	0	0.436	0.425	1.000
250	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	GNPDA1(1), HEXA(1), HK2(1)	851074	3	3	3	0	1	1	0	1	0	0	0.423	0.428	1.000
251	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CDK2(1), FBXW7(1)	441466	2	2	2	0	1	0	0	0	1	0	0.516	0.429	1.000
252	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	GANC(1), GLB1(1), HK2(1), MGAM(3), PFKL(1), PFKP(2), RDH12(1)	1945487	10	7	10	0	4	3	1	1	1	0	0.0419	0.430	1.000
253	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNGR1(1), STAT1(1)	423345	2	2	2	0	0	1	1	0	0	0	0.583	0.431	1.000
254	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	MMP9(1), TIMP3(1)	377013	2	2	2	1	0	1	0	0	1	0	0.945	0.432	1.000
255	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	28	BRAF(1), EGFR(1), ERBB2(2), ERBB4(3), ETS1(2), FMN2(4), GRB2(1), KRAS(2), MAP2K1(1), NOTCH1(1), NOTCH2(2), NOTCH3(2), NOTCH4(2), PIWIL1(1), SOS1(1)	2668402	26	19	25	6	7	10	2	6	1	0	0.266	0.434	1.000
256	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH3A1(1)	383242	1	1	1	0	0	0	0	1	0	0	0.835	0.434	1.000
257	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH3A1(1)	383242	1	1	1	0	0	0	0	1	0	0	0.835	0.434	1.000
258	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ALDH3A1(1), AOX1(2), HADHB(1), HMGCL(2), IVD(1), MCEE(1)	1814396	8	6	8	1	2	1	2	1	2	0	0.323	0.437	1.000
259	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	ELK1(1), MAPK12(1), MAPKAPK2(2), NR2C2(1)	1709993	5	5	5	0	2	0	1	1	1	0	0.221	0.438	1.000
260	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	52	CAMK1G(1), MAP2K1(1), MYH2(2), NFATC2(1), NKX2-5(1), PIK3CA(2), PIK3R1(2), SYT1(1)	2477156	11	8	11	1	1	6	2	2	0	0	0.153	0.441	1.000
261	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	CAMK2B(1), CAMK2D(2), CAMK2G(1), CLCA2(1), PDE1C(1), PRKG1(1), PRKX(1)	1526499	8	7	8	2	2	5	1	0	0	0	0.419	0.451	1.000
262	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	BRAF(1), SNX13(1)	586252	2	2	2	0	0	1	0	1	0	0	0.638	0.453	1.000
263	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	PER1(3)	404593	3	2	3	0	0	1	2	0	0	0	0.421	0.456	1.000
264	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(1), ABCC2(2), ABCG2(1), BCHE(1), CYP3A5(2), UGT1A9(1)	1171130	8	5	8	2	1	3	1	0	2	1	0.704	0.460	1.000
265	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	34	APC(4), AR(1), BRAF(1), EGFR(1), GNA15(1), ITPR1(1), ITPR2(5), ITPR3(2), KCNJ5(1), KCNJ9(1), PIK3CA(2), PIK3R1(2)	2621671	22	13	22	4	3	8	2	6	2	1	0.216	0.461	1.000
266	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(1), CYP11B1(1)	500273	2	2	2	0	0	2	0	0	0	0	0.454	0.464	1.000
267	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(1), CYP11B1(1)	500273	2	2	2	0	0	2	0	0	0	0	0.454	0.464	1.000
268	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BIRC3(1), CASP8(1)	408843	2	2	2	0	0	1	1	0	0	0	0.568	0.465	1.000
269	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	MVD(2)	675218	2	2	2	0	2	0	0	0	0	0	0.465	0.467	1.000
270	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	DAXX(2), ELK1(1), GRB2(1), MAPKAPK2(2), MEF2B(1), STAT1(1)	1886040	8	8	8	2	3	1	2	2	0	0	0.516	0.473	1.000
271	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	APOBEC4(1)	377422	1	1	1	0	0	0	0	1	0	0	0.856	0.473	1.000
272	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	50	ACOX1(1), CD36(1), EP300(3), ME1(1), MRPL11(1), NCOR1(3), PIK3CA(2), PIK3R1(2), PPARA(1), PRKCA(1), STAT5A(1)	3098140	17	10	17	2	0	8	3	4	2	0	0.133	0.473	1.000
273	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	TNFSF13B(1), TRAF5(1)	724225	2	2	2	0	0	0	1	0	1	0	0.531	0.475	1.000
274	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	PLCB1(1)	346081	1	1	1	0	0	0	1	0	0	0	0.785	0.476	1.000
275	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	31	APC(4), LRP1(3), MVP(1), NKD1(1), PTPRA(1), SENP2(1)	2029879	11	9	11	2	4	2	2	0	3	0	0.379	0.476	1.000
276	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	ELK1(1), GRB2(1), MAP2K1(1), NFATC2(1), PIK3CA(2), PIK3R1(2), PLCG1(1), SOS1(1), SYT1(1)	2137641	11	9	11	2	1	5	2	3	0	0	0.361	0.476	1.000
277	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(1), BIRC2(2), BIRC3(1), CASP1(1), CASP8(1), LMNA(1), LMNB1(1)	944403	8	6	8	2	2	4	1	1	0	0	0.525	0.477	1.000
278	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	43	DAXX(2), EGFR(1), ETS1(2), MAP2K1(1), PRKCA(1), PRKCD(1), PRKCQ(1)	2413526	9	9	9	2	2	2	2	2	1	0	0.451	0.478	1.000
279	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	EGFR(1), ELK1(1), GNAS(1), GRB2(1), IGF1R(1), ITGB1(1), MAP2K1(1), PTPRR(1), SOS1(1)	1691547	9	8	9	2	2	5	0	2	0	0	0.408	0.479	1.000
280	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	CALCR(2), GPR64(1), LPHN1(2)	1344127	5	5	5	1	1	3	1	0	0	0	0.446	0.480	1.000
281	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH3A1(1)	419563	1	1	1	0	0	0	0	1	0	0	0.836	0.480	1.000
282	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	CAD(3), CPS1(1), EPRS(1), GAD1(2), GOT1(1)	1952737	8	7	8	2	2	3	1	1	1	0	0.495	0.483	1.000
283	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	BAD(1), EEA1(1), GRASP(1), PFKL(1), PFKP(2), PLCG1(1)	1244434	7	7	7	2	2	3	1	0	1	0	0.522	0.485	1.000
284	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	GLB1(1), HEXA(1), ST6GALNAC3(1)	794819	3	3	3	1	1	1	0	1	0	0	0.708	0.485	1.000
285	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	ELK1(1), GRB2(1), MAP2K1(1), NFATC2(1), PLCG1(1), PRKCA(1), SOS1(1), SYT1(1)	1888472	8	8	8	2	1	3	1	2	1	0	0.519	0.487	1.000
286	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	GLB1(1), GUSB(1), HEXA(1), NAGLU(1)	737323	4	3	4	1	2	1	0	0	1	0	0.667	0.494	1.000
287	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	ACTG1(1), APAF1(1), BIRC2(2), BIRC3(1), CASP8(1), DAXX(2), LMNA(1), LMNB1(1), MDM2(1), PRKCD(1), PRKDC(2), PSEN2(1), PTK2(1), RASA1(1), SPTAN1(1)	3402875	18	11	18	3	3	6	3	2	4	0	0.183	0.502	1.000
288	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH6(1), ALDH3A1(1)	667154	2	2	2	0	0	0	0	1	1	0	0.631	0.504	1.000
289	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B4GALT5(1)	376073	1	1	1	2	0	0	0	0	1	0	0.970	0.504	1.000
290	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	FLT3(1)	424108	1	1	1	1	0	0	0	0	1	0	0.904	0.507	1.000
291	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	GLB1(1), HK2(1), MGAM(3), PFKP(2)	1617617	7	6	7	0	3	3	0	0	1	0	0.0934	0.512	1.000
292	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	RDH12(1)	432556	1	1	1	0	0	0	0	1	0	0	0.836	0.514	1.000
293	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	CTSD(1), GREB1(1)	549508	2	2	2	1	0	1	0	0	1	0	0.742	0.517	1.000
294	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ARPC2(1), NTRK1(1), WASF2(1)	782076	3	3	3	1	0	3	0	0	0	0	0.748	0.517	1.000
295	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2B(1), CAMK2D(2), CAMK2G(1), ITPR1(1), ITPR2(5), ITPR3(2), PDE6C(1)	1752988	13	6	13	2	2	5	0	4	1	1	0.211	0.520	1.000
296	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	GABBR1(1), GRM1(1), GRM3(2), GRM5(1), GRM7(1), GRM8(1)	921295	7	7	7	3	0	4	1	1	1	0	0.672	0.520	1.000
297	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(1), EGFR(1)	653137	2	2	2	1	0	1	0	0	1	0	0.853	0.526	1.000
298	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	RAB6A(1)	219244	1	1	1	0	0	0	0	1	0	0	0.850	0.527	1.000
299	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH6(1), ALDH3A1(1), CEL(1), DGAT1(1), DGKA(2), DGKB(1), GLB1(1), LIPC(1), LIPF(1), PPAP2A(1)	2435281	11	8	11	1	1	4	4	1	1	0	0.161	0.527	1.000
300	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(1), CAPN1(1)	487177	2	2	2	0	0	0	1	1	0	0	0.665	0.528	1.000
301	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	STAT1(1), STAT2(1), TYK2(2)	557715	4	2	4	1	0	0	2	1	1	0	0.794	0.528	1.000
302	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AASS(1)	363253	1	1	1	1	0	1	0	0	0	0	0.954	0.530	1.000
303	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	MTHFD2(1), POLB(1)	647923	2	2	2	0	0	1	0	1	0	0	0.599	0.531	1.000
304	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	NDUFA13(2)	216942	2	1	2	0	0	0	1	0	1	0	0.761	0.533	1.000
305	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ALDH3A1(1), GOT1(1), LPO(1), MAOB(1), SH3GLB1(1)	1676243	5	5	5	0	1	2	0	2	0	0	0.246	0.535	1.000
306	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BAD(1), CASP8(1), MAP2K1(1)	992184	3	3	3	1	0	2	0	1	0	0	0.762	0.537	1.000
307	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	MAP2K1(1)	417222	1	1	1	0	0	0	0	1	0	0	0.836	0.540	1.000
308	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(1)	451489	1	1	1	1	0	0	1	0	0	0	0.934	0.544	1.000
309	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(1)	341335	1	1	1	0	1	0	0	0	0	0	0.664	0.545	1.000
310	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	GOT1(1)	339991	1	1	1	0	1	0	0	0	0	0	0.698	0.550	1.000
311	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(1), ATP5O(1), ATP6V1G1(1), ATP7B(2), NDUFV1(1), SDHA(1)	1906796	7	5	7	0	1	1	0	3	2	0	0.167	0.550	1.000
312	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	FBP1(1), PFKP(2), PGD(2), PRPS1(1)	949815	6	5	6	2	3	2	0	1	0	0	0.571	0.551	1.000
313	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CAMK1G(1), ELK1(1), FPR1(1), GNA15(1), MAP2K1(1), NFATC2(1), PIK3C2G(2), PLCB1(1), SYT1(1)	1958702	10	7	10	2	0	5	3	2	0	0	0.409	0.553	1.000
314	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(2)	240643	2	1	2	0	0	0	1	0	1	0	0.650	0.553	1.000
315	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(1), BAD(1), CASP1(1), CASP8(1), DAXX(2), NTRK1(1), PTPN13(1), TFG(1)	2158545	9	7	9	1	1	7	0	1	0	0	0.238	0.557	1.000
316	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP2(1), TYR(1)	773104	2	2	2	0	2	0	0	0	0	0	0.472	0.564	1.000
317	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	FUT6(1)	250627	1	1	1	1	0	1	0	0	0	0	0.896	0.568	1.000
318	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	TYK2(2)	536298	2	2	2	0	0	0	1	0	1	0	0.784	0.569	1.000
319	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	TYK2(2)	536298	2	2	2	0	0	0	1	0	1	0	0.784	0.569	1.000
320	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	APOA4(1), DGAT1(1), LIPC(1), LRP1(3)	1308990	6	5	6	2	2	0	4	0	0	0	0.771	0.570	1.000
321	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(1), BIRC2(2), BIRC3(1), CASP8(1), LMNA(1), SPTAN1(1)	1611136	7	5	7	1	1	3	1	1	1	0	0.375	0.575	1.000
322	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	GNAS(1), HLA-DRA(1), PTPRC(1), ZAP70(1)	1119746	4	4	4	0	2	1	0	0	1	0	0.256	0.576	1.000
323	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	GNAS(1), HLA-DRA(1), PTPRC(1), ZAP70(1)	1119746	4	4	4	0	2	1	0	0	1	0	0.256	0.576	1.000
324	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(1), ATP5G2(1), ATP5O(1), ATP6V0D2(1), ATP6V1G1(1), COX15(1), CYC1(1), NDUFA13(2), NDUFA9(1), NDUFB10(1), NDUFV1(1), SDHA(1)	2835444	13	8	13	1	1	4	1	2	5	0	0.136	0.580	1.000
325	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	HADHB(1)	417073	1	1	1	0	0	0	0	0	1	0	0.763	0.581	1.000
326	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	DRD1(1), GRM1(1), PLCB1(1)	741288	3	2	3	0	1	1	1	0	0	0	0.386	0.583	1.000
327	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTN2(1), CAPN1(1), ITGB1(1), PTK2(1), SPTAN1(1), TLN1(1)	1366794	6	5	6	1	1	2	2	0	1	0	0.399	0.583	1.000
328	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	GOT1(1), SULT4A1(1)	641064	2	2	2	0	1	1	0	0	0	0	0.503	0.584	1.000
329	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	CDK2(1), CDKN1A(1), PIK3CA(2), PIK3R1(2)	1019206	6	3	6	0	0	2	1	1	2	0	0.271	0.585	1.000
330	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	CASP8(1), DAXX(2), LMNA(1), LMNB1(1), PRKDC(2), PTPN13(1), SPTAN1(1)	2134715	9	7	9	2	2	4	0	1	2	0	0.468	0.585	1.000
331	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(1), BAD(1)	588672	2	2	2	1	0	2	0	0	0	0	0.856	0.587	1.000
332	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	CHIA(1), GNPDA1(1), HEXA(1), HK2(1)	1463594	4	4	4	0	1	1	0	1	1	0	0.289	0.588	1.000
333	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	IMPA1(1), INPPL1(1), PIK3C2G(2), PIK3CA(2), PIK3CB(2), PLCB1(1), PLCG1(1)	2279718	10	7	10	1	1	5	2	2	0	0	0.219	0.588	1.000
334	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	CFTR(1), GNAS(1)	658149	2	2	2	0	1	0	0	0	1	0	0.525	0.591	1.000
335	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	FBP1(1), PFKL(1), PFKP(2), PGD(2), PRPS1(1)	1150118	7	6	7	2	3	2	1	1	0	0	0.512	0.594	1.000
336	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH6(1)	290545	1	1	1	0	0	0	0	0	1	0	0.739	0.596	1.000
337	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	HADHB(1)	433250	1	1	1	0	0	0	0	0	1	0	0.754	0.599	1.000
338	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CD36(1)	351652	1	1	1	0	0	1	0	0	0	0	0.736	0.600	1.000
339	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	CDKN1A(1), GRIN1(1)	619263	2	2	2	0	0	0	0	0	2	0	0.745	0.602	1.000
340	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	DAB1(1), LRP8(2)	689318	3	2	3	1	1	2	0	0	0	0	0.680	0.605	1.000
341	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(1), ATP6V0D2(1), ATP6V1G1(1), GNAS(1), PDIA4(1), PLCG1(1), PRKCA(1)	1846651	7	6	7	1	4	2	0	0	1	0	0.258	0.607	1.000
342	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	STAT1(1), STAT2(1), TYK2(2)	617379	4	2	4	1	0	0	2	1	1	0	0.810	0.608	1.000
343	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	F13A1(2), FGB(1)	672102	3	2	3	0	1	2	0	0	0	0	0.376	0.610	1.000
344	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	IFNGR1(1), STAT1(1)	557621	2	2	2	0	0	1	1	0	0	0	0.572	0.611	1.000
345	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ITGB1(1), SELP(1)	785904	2	2	2	0	0	1	0	0	1	0	0.539	0.618	1.000
346	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACOX1(1), FADS1(1)	732060	2	2	2	0	0	1	0	1	0	0	0.576	0.629	1.000
347	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	IARS(2), VARS(1)	923223	3	3	3	1	1	2	0	0	0	0	0.742	0.633	1.000
348	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYB(1)	322498	1	1	1	0	0	1	0	0	0	0	0.798	0.637	1.000
349	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	FBXW7(1), GRB2(1), ITK(1), NFKB2(2), PLCG1(1), PTPRC(1), RASGRP2(1), SOS1(1), ZAP70(1)	2824774	10	9	10	0	2	6	0	0	2	0	0.0373	0.637	1.000
350	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	PAFAH1B1(1), PAFAH1B2(2), PLA2G1B(1), PLD1(1), PPAP2A(1)	1174545	6	4	6	1	0	3	2	0	1	0	0.436	0.643	1.000
351	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	16	IFRD1(1)	543759	1	1	1	0	0	0	0	0	1	0	1.000	0.650	1.000
352	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH3A1(1)	591692	1	1	1	0	0	0	0	1	0	0	0.833	0.651	1.000
353	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	HSD17B7(1)	405678	1	1	1	0	0	1	0	0	0	0	0.735	0.651	1.000
354	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(1), ATP6V1G1(1)	757088	2	2	2	0	0	1	0	1	0	0	0.608	0.651	1.000
355	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(1), ATP6V1G1(1)	757088	2	2	2	0	0	1	0	1	0	0	0.608	0.651	1.000
356	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(1), ATP6V1G1(1)	757088	2	2	2	0	0	1	0	1	0	0	0.608	0.651	1.000
357	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(1), CDIPT(1), DGKA(2), DGKB(1), GPD2(1), PAFAH1B1(1), PLA2G1B(1), PLCG1(1), PPAP2A(1)	2504903	10	8	10	1	1	5	4	0	0	0	0.172	0.655	1.000
358	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(4), EP300(3), FZD1(1)	1589308	8	7	8	2	1	4	0	1	2	0	0.572	0.657	1.000
359	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(4)	1357975	4	4	4	0	1	1	0	0	2	0	0.363	0.660	1.000
360	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	16	ALOX15(1), PTGS1(1)	776716	2	2	2	0	0	1	1	0	0	0	0.558	0.662	1.000
361	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	GNAS(1), PRKAA2(1)	770772	2	2	2	1	1	0	0	0	1	0	0.958	0.662	1.000
362	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	BRAF(1), EGFR(1), GRB2(1), ITPR1(1), ITPR2(5), ITPR3(2), KCNJ5(1), KCNJ9(1), PIK3CB(2), PLCB1(1), RGS20(1), SOS1(1)	2893497	18	10	18	3	3	6	2	5	1	1	0.206	0.666	1.000
363	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	33	CDKN2A(2), ITPR1(1), ITPR2(5), ITPR3(2), PIK3CA(2), PPP1R13B(1), PTEN(2), PTPRC(1), RPS6KA2(2), RPS6KA3(1)	2781969	19	10	19	4	3	5	2	6	2	1	0.356	0.669	1.000
364	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADVL(1), ACSL3(1), SCP2(1)	852335	3	3	3	0	0	2	0	0	1	0	0.567	0.670	1.000
365	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	GNAS(1)	332935	1	1	1	0	1	0	0	0	0	0	0.730	0.673	1.000
366	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	LPO(1), PRDX1(1)	582887	2	2	2	0	0	1	0	0	1	0	0.692	0.674	1.000
367	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	VNN2(1)	602741	1	1	1	0	0	0	0	0	1	0	0.674	0.676	1.000
368	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(1), GUSB(1), GYS1(1), GYS2(1), HK2(1), MGAM(3), PYGB(1), PYGM(1), RNPC3(2), SI(1), UGT1A9(1), UGT2B15(2), UXS1(1)	2966258	17	11	17	4	4	5	4	1	3	0	0.461	0.680	1.000
369	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ELK1(1), GNAS(1), MAP2K1(1), NFATC2(1), PLCG1(1), PRKCA(1), RPS6KA3(1), SYT1(1)	1708546	8	7	8	2	1	2	2	2	1	0	0.551	0.680	1.000
370	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	HEXA(1)	486841	1	1	1	0	1	0	0	0	0	0	0.683	0.681	1.000
371	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	AK3(1), CAD(3), POLB(1), POLE(5), UPP1(1)	2844066	11	9	11	2	1	7	2	0	1	0	0.266	0.683	1.000
372	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	GCDH(1)	390196	1	1	1	0	0	1	0	0	0	0	0.745	0.683	1.000
373	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPLD1(1), PIGS(2)	1239609	3	3	3	1	1	1	0	0	1	0	0.788	0.684	1.000
374	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(1), ARSD(1), CYP11B1(1), HSD17B7(1), PRMT3(2), PRMT7(1), STS(1), UGT1A9(1), UGT2B15(2), UGT2B17(1), WBSCR22(1)	2548971	13	9	13	3	1	5	3	1	3	0	0.517	0.684	1.000
375	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ALDH3A1(1), SH3GLB1(1), YOD1(1)	1462648	3	3	3	0	0	1	0	2	0	0	0.529	0.688	1.000
376	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	DNMT1(1), MTR(1)	875873	2	2	2	0	1	0	0	1	0	0	0.568	0.692	1.000
377	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACADVL(1), ACOX1(1), ACSL3(1), ACSL5(1), ACSL6(1), ADH6(1), ALDH3A1(1), CPT1C(1), GCDH(1), HADHB(1)	2449768	10	8	10	2	1	3	1	2	3	0	0.465	0.692	1.000
378	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(1), ADH6(1), SH3GLB1(1)	1178987	3	3	3	0	0	1	0	1	1	0	0.479	0.699	1.000
379	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	CAP1(1), CDC25C(1), GNAS(1)	997906	3	3	3	0	1	2	0	0	0	0	0.357	0.701	1.000
380	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	GCDH(1), SH3GLB1(1), YOD1(1)	1224751	3	3	3	0	0	2	0	1	0	0	0.476	0.701	1.000
381	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	EGFR(1), ELK1(1), GRB2(1), MAP2K1(1), MEF2B(1), PRKCA(1), PTK2(1), SOS1(1), SYT1(1)	1741619	9	8	9	3	2	3	1	2	1	0	0.637	0.701	1.000
382	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	HEXA(1)	518327	1	1	1	0	1	0	0	0	0	0	0.680	0.702	1.000
383	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	UBE3A(1)	546146	1	1	1	1	0	0	0	0	1	0	1.000	0.707	1.000
384	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	93	CARD11(1), GRB2(1), ITK(1), KRAS(2), MAP3K8(1), NFATC2(1), NFKB2(2), PIK3CA(2), PIK3CB(2), PIK3R1(2), PLCG1(1), PRKCQ(1), PTPRC(1), SOS1(1), VAV3(1), ZAP70(1)	5085639	21	13	21	2	1	10	5	2	3	0	0.0451	0.708	1.000
385	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	EP300(3)	669347	3	2	3	0	0	2	0	1	0	0	0.455	0.708	1.000
386	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	CAMK2B(1), CAMK2D(2), CAMK2G(1), GRB2(1), MAP2K1(1), PLCG1(1), PRKCA(1), SOS1(1), STAT1(1), STAT5A(1), SYT1(1)	2095668	12	9	12	3	2	7	1	1	1	0	0.417	0.715	1.000
387	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ARPC2(1)	409893	1	1	1	1	0	1	0	0	0	0	0.939	0.717	1.000
388	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFV1(1)	365096	1	1	1	0	0	0	0	0	1	0	0.839	0.718	1.000
389	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	PPCS(1), VNN1(2)	876694	3	2	3	0	0	0	1	1	1	0	0.472	0.721	1.000
390	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN2(1), CTNNA2(3), PTK2(1)	968054	5	5	5	2	1	2	1	1	0	0	0.720	0.721	1.000
391	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	UROD(1)	341822	1	1	1	0	0	0	1	0	0	0	0.760	0.738	1.000
392	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	IL10RA(1), STAT1(1), STAT5A(1)	610417	3	2	3	0	0	2	1	0	0	0	0.396	0.740	1.000
393	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT4(2), GCNT1(1)	747844	3	2	3	0	0	1	1	0	1	0	0.404	0.744	1.000
394	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	PPCS(1)	700052	1	1	1	0	0	0	0	1	0	0	0.841	0.747	1.000
395	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	ELK1(1), GRB2(1), MAP2K1(1), RPS6KA3(1), SOS1(1), VAV3(1)	1602570	6	5	6	2	1	1	1	2	1	0	0.710	0.750	1.000
396	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	PIK3C3(1), PRKAA2(1)	1083357	2	2	2	1	0	0	0	0	2	0	0.938	0.756	1.000
397	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	78	BRAF(1), CAV1(1), CDKN2A(2), CSE1L(2), DOCK1(1), GRB2(1), GRB7(1), ITGA4(2), ITGA6(1), ITGA7(1), ITGA8(1), ITGA9(2), MAP3K11(1), PIK3CA(2), PIK3CB(2), PKLR(1), PLCG1(1), PTEN(2), PTK2(1), ROCK1(2), SOS1(1), TLN1(1), TLN2(1), ZYX(2)	6113940	33	21	33	5	5	16	4	6	2	0	0.0554	0.758	1.000
398	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	SH3GLB1(1)	748389	1	1	1	0	0	0	0	1	0	0	0.852	0.762	1.000
399	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	FBP1(1), HK2(1), PFKP(2)	1173438	4	3	4	1	2	1	0	1	0	0	0.554	0.763	1.000
400	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	18	IKBKAP(1), TANK(1)	1097131	2	2	2	1	0	0	1	0	1	0	0.881	0.765	1.000
401	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	99	CASP8(1), IL12B(1), MAP2K1(1), MAP3K8(1), MAPK12(1), NFKB2(2), PIK3CA(2), PIK3CB(2), PIK3R1(2), STAT1(1), TICAM1(1), TLR1(2), TLR8(1), TLR9(1)	4378119	19	11	19	2	1	9	3	4	2	0	0.0739	0.768	1.000
402	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	29	CABIN1(1), CAMK1G(1), HDAC5(1), IGF1R(1), MEF2B(1), NFATC2(1), PIK3CA(2), PIK3R1(2), SYT1(1)	1726436	11	8	11	3	1	7	2	1	0	0	0.436	0.773	1.000
403	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	LPO(1)	417568	1	1	1	0	0	1	0	0	0	0	0.687	0.774	1.000
404	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	UROD(1)	379294	1	1	1	0	0	0	1	0	0	0	0.772	0.778	1.000
405	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(1), EP300(3), NFATC2(1), PRKCA(1), SYT1(1)	1192574	7	5	7	2	0	4	1	1	1	0	0.584	0.779	1.000
406	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	35	ARHGEF11(1), NFKB2(2), PIK3CB(2), PLD1(1), PTK2(1), RDX(1), ROCK1(2), TBXA2R(1)	2516935	11	6	11	2	1	3	2	3	2	0	0.375	0.781	1.000
407	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CDK2(1)	453072	1	1	1	1	0	0	0	0	1	0	0.947	0.784	1.000
408	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGFR(1)	522465	1	1	1	1	0	1	0	0	0	0	0.937	0.791	1.000
409	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IL12B(1)	496054	1	1	1	0	0	0	0	1	0	0	0.846	0.791	1.000
410	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ALDH3A1(1), AOX1(2), DLD(1), HADHB(1), HMGCL(2), IVD(1), MCEE(1)	2186976	9	7	9	2	2	2	2	1	2	0	0.510	0.795	1.000
411	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	CASP8(1), LMNA(1), LMNB1(1), PRKDC(2), SPTAN1(1)	1975457	6	5	6	2	2	2	0	0	2	0	0.633	0.796	1.000
412	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	ARAF(2), BRAF(1), CACNA1A(1), GNA12(1), GNAS(1), GRIA2(1), GRM1(1), GRM5(1), GUCY1A3(2), GUCY2C(1), GUCY2D(1), IGF1R(1), ITPR1(1), ITPR2(5), ITPR3(2), KRAS(2), MAP2K1(1), NOS1(2), NOS3(1), NPR2(2), PLA2G1B(1), PLCB1(1), PRKCA(1), PRKG1(1), RYR1(3)	5583014	37	21	36	8	9	12	3	8	4	1	0.124	0.796	1.000
413	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	152	CNTFR(1), EP300(3), GRB2(1), IFNGR1(1), IL10RA(1), IL12B(1), IL12RB2(2), IL22RA1(1), IL24(1), IL6ST(2), IL9R(1), IRF9(1), JAK3(1), PIK3CA(2), PIK3CB(2), PIK3R1(2), SOS1(1), SPRED1(2), SPRY1(1), SPRY4(1), STAT1(1), STAT2(1), STAT5A(1), STAT6(2), TYK2(2)	7302434	35	17	34	2	3	19	6	5	2	0	0.00310	0.809	1.000
414	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AASS(1), ALDH3A1(1), DOT1L(2), EHMT2(1), GCDH(1), NSD1(1), OGDHL(1), PLOD1(1), PLOD2(1), RDH12(1), SETD7(1)	2885060	12	11	12	3	2	6	1	2	1	0	0.428	0.810	1.000
415	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(1), ARSD(1), CYP11B1(1), STS(1), UGT1A9(1), UGT2B15(2)	1392529	7	5	7	2	0	4	1	0	2	0	0.731	0.811	1.000
416	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(1), BIRC2(2), BIRC3(1), CASP8(1)	870159	5	4	5	2	0	3	1	1	0	0	0.784	0.815	1.000
417	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	91	ACTB(1), BAD(1), CABIN1(1), CAMK2B(1), CDKN1A(1), EP300(3), FOSL1(1), GATA3(2), ITK(1), KPNA5(1), MEF2B(1), MYF5(1), NFATC2(1), NFKB2(2), OPRD1(1), PTPRC(1), VAV3(1), XPO5(2)	4454657	23	17	23	5	5	10	2	1	5	0	0.200	0.815	1.000
418	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(1), ABCB11(1), ABCC1(1)	730511	3	3	3	4	2	0	0	0	1	0	0.984	0.818	1.000
419	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	EP300(3)	886105	3	2	3	1	0	2	0	1	0	0	0.792	0.820	1.000
420	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	PRKAA2(1)	746863	1	1	1	1	0	0	0	0	1	0	1.000	0.820	1.000
421	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	BAD(1), CHRNG(1), PIK3CA(2), PIK3R1(2), PTK2(1)	814867	7	5	7	3	0	4	2	1	0	0	0.799	0.825	1.000
422	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR3B(1), POLR3H(1)	1149684	2	2	2	1	0	1	0	0	1	0	0.802	0.829	1.000
423	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	HK2(1), IMPA1(1)	512807	2	1	2	0	0	1	0	1	0	0	0.599	0.834	1.000
424	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	KDR(2), NOS3(1), PIK3CA(2), PIK3R1(2), PLCG1(1), PRKCA(1), PTK2(1)	1737794	10	8	10	3	1	5	2	1	1	0	0.564	0.841	1.000
425	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ARHGAP5(1), ARHGEF11(1), ARPC2(1), BAIAP2(1), ROCK1(2), TLN1(1)	2230958	7	7	7	2	1	3	1	2	0	0	0.591	0.844	1.000
426	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	ARHGEF11(1), GDI1(1), INPPL1(1), ITPR1(1), ITPR2(5), ITPR3(2), PIK3CA(2), PIK3R1(2), PPP1R13B(1), PTEN(2), RACGAP1(1), ROCK1(2)	3486913	21	11	21	4	3	5	3	7	2	1	0.288	0.845	1.000
427	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	FBP1(1), FUK(1), HK2(1), PFKL(1), PFKP(2), RDH12(1)	1886602	7	4	7	1	3	1	1	2	0	0	0.327	0.846	1.000
428	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	ANKHD1(1), EIF4G1(3), PABPC3(2)	2242125	6	5	6	1	2	1	1	1	1	0	0.444	0.848	1.000
429	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	GLI2(1)	796344	1	1	1	0	0	0	0	0	1	0	0.717	0.851	1.000
430	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOSL1(1)	540345	1	1	1	0	0	1	0	0	0	0	0.752	0.853	1.000
431	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	LPO(1)	547518	1	1	1	0	0	1	0	0	0	0	0.689	0.858	1.000
432	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	TGFBR2(1)	508208	1	1	1	1	0	0	1	0	0	0	0.940	0.858	1.000
433	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ADCY8(1), CACNA1A(1), GNAS(1), ITPR3(2), KCNB1(1), PRKX(1), SCNN1A(1), TAS1R2(1), TAS2R3(1), TAS2R41(1), TAS2R9(1), TRPM5(1)	2733198	13	8	13	2	5	3	3	1	1	0	0.239	0.858	1.000
434	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	67	ADCY8(1), ARAF(2), ATF4(1), BRAF(1), CACNA1C(1), CAMK2B(1), CAMK2D(2), CAMK2G(1), EP300(3), GRIA2(1), GRIN1(1), GRIN2A(2), GRIN2D(3), GRM1(1), GRM5(1), ITPR1(1), ITPR2(5), ITPR3(2), KRAS(2), MAP2K1(1), PLCB1(1), PPP1CB(1), PRKCA(1), PRKX(1), RPS6KA2(2), RPS6KA3(1)	5009485	40	19	39	7	6	17	4	9	3	1	0.0578	0.862	1.000
435	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B3GNT6(2), B4GALT5(1), GALNT11(1), GALNT14(1), GALNT4(2), GALNT5(1), GALNTL5(1), GCNT1(1), GCNT4(1)	1622418	11	10	11	5	2	4	2	0	3	0	0.774	0.863	1.000
436	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	JAK3(1)	685882	1	1	1	1	0	1	0	0	0	0	0.939	0.866	1.000
437	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	EDNRB(1), PTGER2(1), PTGER4(1), PTGS1(1)	1001602	4	4	4	2	1	0	2	0	1	0	0.831	0.866	1.000
438	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	66	ADAM17(1), ATP6V0D2(1), ATP6V1G1(1), EGFR(1), MAPK12(1), NFKB2(2), PLCG1(1), TJP1(1)	3517571	9	8	9	1	1	5	0	0	3	0	0.200	0.868	1.000
439	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	13	IKBKAP(1)	910291	1	1	1	1	0	0	1	0	0	0	0.939	0.871	1.000
440	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	GNAS(1)	740295	1	1	1	0	1	0	0	0	0	0	0.706	0.875	1.000
441	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	HK2(1), IMPA1(1)	581876	2	1	2	1	0	1	0	1	0	0	0.834	0.877	1.000
442	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	CP(1), EPRS(1), GUSB(1), UGT1A9(1), UGT2B15(2), UROD(1)	1383348	7	5	7	2	0	2	2	1	2	0	0.794	0.878	1.000
443	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	FBP1(1), GOT1(1), ME1(1), ME3(1), PKLR(1)	871333	5	4	5	3	1	2	0	2	0	0	0.860	0.880	1.000
444	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	ASNS(1), CAD(3), CRAT(1), DLD(1), GAD1(2), GOT1(1)	1877810	9	7	9	3	2	5	1	0	1	0	0.564	0.884	1.000
445	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	27	ADRBK1(1), ITPR1(1), ITPR2(5), ITPR3(2), NFKB2(2), PIK3CB(2), PLD1(1)	2233955	14	7	14	4	1	5	1	4	2	1	0.473	0.884	1.000
446	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDK2(1), POLA2(1), POLE(5), POLE2(1), RFC2(1), RFC3(1)	2526509	10	7	10	2	0	5	2	1	2	0	0.389	0.885	1.000
447	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	SCLY(2)	625479	2	1	2	0	0	2	0	0	0	0	0.505	0.885	1.000
448	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	OPRK1(1)	597653	1	1	1	0	0	1	0	0	0	0	0.716	0.891	1.000
449	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	16	EP300(3)	1058535	3	2	3	0	0	2	0	1	0	0	0.466	0.894	1.000
450	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ALDH3A1(1), CPS1(1), GOT1(1), MAOB(1), NOS1(2), NOS3(1), P4HA2(2), SMS(1)	2238533	10	8	10	3	1	5	0	1	3	0	0.549	0.895	1.000
451	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	JAK3(1)	747842	1	1	1	0	0	1	0	0	0	0	0.702	0.897	1.000
452	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	CPS1(1), SMS(1)	894246	2	2	2	2	0	1	0	0	1	0	0.932	0.897	1.000
453	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	CPS1(1), EPRS(1), GOT1(1), LAP3(1), NOS1(2), NOS3(1), P4HA2(2)	1842314	9	7	9	3	1	4	1	1	2	0	0.661	0.898	1.000
454	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ACACB(1), ACSS2(1), ALDH3A1(1), MCEE(1)	1987287	4	4	4	0	0	2	1	1	0	0	0.351	0.902	1.000
455	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(2), QPRT(1)	734484	3	1	3	1	0	0	1	1	1	0	0.827	0.904	1.000
456	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	B4GALT5(1), ST6GAL1(1)	965106	2	2	2	2	0	0	1	0	1	0	0.930	0.908	1.000
457	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	ALDH3A1(1), AOX1(2), GCDH(1), HAAO(1), KYNU(1), MAOB(1), OGDHL(1), PRMT3(2), PRMT7(1), WBSCR22(1)	3050529	12	9	12	4	1	3	3	3	2	0	0.677	0.908	1.000
458	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	FBP1(1), GOT1(1), ME1(1), ME3(1), PKLR(1)	960332	5	4	5	3	1	2	0	2	0	0	0.858	0.910	1.000
459	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ACTB(1), ACTG1(1), ARHGEF2(1), CDH1(1), CLDN1(1), EZR(1), ITGB1(1), PRKCA(1), ROCK1(2), TUBA3D(1), TUBB1(1), TUBB2A(1)	2673491	13	11	13	4	1	6	1	3	2	0	0.542	0.914	1.000
460	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ACTB(1), ACTG1(1), ARHGEF2(1), CDH1(1), CLDN1(1), EZR(1), ITGB1(1), PRKCA(1), ROCK1(2), TUBA3D(1), TUBB1(1), TUBB2A(1)	2673491	13	11	13	4	1	6	1	3	2	0	0.542	0.914	1.000
461	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	DLD(1), MAOB(1), RDH12(1), SARDH(1)	2185408	4	4	4	1	1	2	0	1	0	0	0.585	0.914	1.000
462	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(1), EDNRB(1), EGFR(1), PLCG1(1), PRKCA(1)	973148	5	4	5	3	0	3	0	0	2	0	0.879	0.915	1.000
463	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACB(1)	797768	1	1	1	0	0	1	0	0	0	0	0.697	0.922	1.000
464	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSD(1), GLB1(1), NEU4(1), PPAP2A(1)	1171708	4	3	4	2	0	2	1	0	1	0	0.814	0.927	1.000
465	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	GLB1(1), GUSB(1), HEXA(1), HPSE2(1), MANBA(1), NAGLU(1), NEU4(1)	1707149	7	5	7	3	3	2	0	0	2	0	0.735	0.928	1.000
466	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	PYGM(1)	678698	1	1	1	1	0	0	1	0	0	0	0.939	0.941	1.000
467	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ALDH3A1(1), CPS1(1), MAOB(1), SMS(1)	1456542	4	4	4	2	0	2	0	1	1	0	0.809	0.941	1.000
468	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	DLD(1), MAOB(1), PLCG1(1), SARDH(1)	2106012	4	4	4	1	1	3	0	0	0	0	0.530	0.941	1.000
469	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	130	ACTB(1), ACTG1(1), ACTN2(1), ASH1L(1), CASK(1), CLDN1(1), CLDN16(2), CTNNA2(3), CTNNA3(1), EXOC4(1), INADL(1), KRAS(2), LLGL2(1), MLLT4(2), MPDZ(5), MPP5(1), MYH1(1), MYH10(1), MYH13(1), MYH15(2), MYH2(2), MYH7(1), MYH8(1), MYH9(1), PARD3(1), PPM1J(1), PRKCA(1), PRKCD(1), PRKCI(1), PRKCQ(1), PTEN(2), RAB3B(1), SPTAN1(1), TJP1(1)	9703972	46	25	45	7	7	19	10	3	7	0	0.0251	0.941	1.000
470	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	EP300(3), NOS3(1)	856201	4	3	4	2	0	3	0	1	0	0	0.824	0.942	1.000
471	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSD(1), GLB1(1), NEU4(1), PPAP2A(1), SMPD3(1), SPHK2(3)	1760342	8	5	8	2	2	2	2	0	2	0	0.480	0.943	1.000
472	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	CAPN1(1), EGFR(1), ITGB1(1), PTK2(1), TLN1(1)	1604237	5	4	5	2	0	3	2	0	0	0	0.723	0.946	1.000
473	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	129	ACACB(1), ARAF(2), BAD(1), BRAF(1), CRKL(1), ELK1(1), FBP1(1), GRB2(1), GYS1(1), GYS2(1), IRS1(2), KRAS(2), MAP2K1(1), PDE3A(1), PDE3B(1), PFKL(1), PFKP(2), PHKA1(3), PHKB(1), PIK3CA(2), PIK3CB(2), PIK3R1(2), PKLR(1), PPP1CB(1), PPP1R3A(1), PPP1R3C(1), PRKAA2(1), PRKCI(1), PRKX(1), PTPRF(1), PYGB(1), PYGM(1), SH2B2(1), SHC4(2), SORBS1(2), SOS1(1), TSC1(1), TSC2(2)	7923678	50	25	49	7	9	23	9	7	2	0	0.0115	0.948	1.000
474	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ALDH3A1(1), MCEE(1)	1676700	2	2	2	0	0	0	1	1	0	0	0.625	0.953	1.000
475	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXTL3(1), NDST3(1), NDST4(1)	1036974	3	3	3	2	0	1	1	0	1	0	0.857	0.954	1.000
476	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	25	TANK(1)	1222671	1	1	1	1	0	0	0	0	1	0	0.958	0.958	1.000
477	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	EP300(3), TGFBR2(1)	1405352	4	2	4	1	0	2	1	1	0	0	0.674	0.959	1.000
478	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG1(1), FLNA(1), FSCN1(1), GDI1(1), MYH2(2), ROCK1(2)	2387698	8	8	8	3	1	3	2	2	0	0	0.716	0.959	1.000
479	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	CAPN1(1), CAPN9(1), CAV1(1), DOCK1(1), GRB2(1), ITGA4(2), ITGA6(1), ITGA7(1), ITGA8(1), ITGA9(2), ITGAL(1), ITGAV(1), ITGAX(1), ITGB1(1), ITGB4(2), ITGB6(1), ITGB7(1), ITGB8(1), MAP2K1(1), MAPK12(1), PTK2(1), ROCK1(2), SORBS1(2), SOS1(1), TLN1(1), VAV3(1), ZYX(2)	6775941	33	19	33	6	3	15	5	5	5	0	0.107	0.962	1.000
480	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	39	EIF4G2(2), HSPA8(1), NCOA4(2), PER1(3), PER2(1), PPP1R3C(1)	1842391	10	6	10	3	0	6	4	0	0	0	0.648	0.964	1.000
481	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(1), DLD(1), IDH2(2), PDP2(1), SDHA(1)	1427921	6	6	6	3	0	4	1	1	0	0	0.834	0.971	1.000
482	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	APC(4), BMP4(1), BMP5(1), FZD1(1), NKX2-5(1), TGFBR2(1)	1800238	9	7	9	5	2	3	1	1	2	0	0.907	0.973	1.000
483	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(2), QPRT(1)	1086985	3	1	3	3	0	0	1	1	1	0	0.979	0.974	1.000
484	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	GLB1(1), GUSB(1), HEXA(1), HPSE2(1), NAGLU(1)	1038612	5	3	5	3	2	2	0	0	1	0	0.883	0.975	1.000
485	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ASCC3(1), DDX19A(1), DDX52(1), DDX56(1), EP400(4), ERCC2(1), RAD54B(1), RAD54L(1), RUVBL2(1), SETX(1), SMARCA2(1), SMARCA5(3)	3150713	17	12	17	5	2	6	2	2	5	0	0.575	0.977	1.000
486	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	ACHE(1), CDIPT(1), DGKA(2), DGKB(1), DGKI(1), GPD2(1), PLA2G1B(1), PLD1(1), PPAP2A(1), SH3GLB1(1)	3277693	11	7	11	2	1	3	5	1	1	0	0.337	0.978	1.000
487	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	95	ADCY8(1), ATF4(1), CACNA1C(1), CACNA1D(1), CACNA1F(1), CAMK2B(1), CAMK2D(2), CAMK2G(1), EGFR(1), ELK1(1), FSHB(1), GNAS(1), GRB2(1), ITPR1(1), ITPR2(5), ITPR3(2), KRAS(2), MAP2K1(1), MAP3K2(1), MAPK12(1), PLA2G1B(1), PLCB1(1), PLD1(1), PRKCA(1), PRKCD(1), PRKX(1), SOS1(1)	6453811	34	19	34	8	6	10	6	7	4	1	0.191	0.979	1.000
488	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP2(1), CYP2D6(1), CYP2E1(1), CYP3A5(2)	1517085	5	3	5	5	1	1	0	0	2	1	0.999	0.979	1.000
489	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	PIK3CA(2), PIK3R1(2), PLD1(1), TRIO(1)	1753615	6	4	6	3	0	2	1	1	2	0	0.838	0.980	1.000
490	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	MAN1A2(1), MAN1C1(1), MGAT5B(1), ST6GAL1(1)	2132143	4	3	4	2	0	1	1	0	2	0	0.813	0.983	1.000
491	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ANPEP(1), CMA1(1), CTSA(1), MME(2)	1042735	5	5	5	3	2	2	1	0	0	0	0.874	0.983	1.000
492	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	73	CDIPT(1), DGKA(2), DGKB(1), DGKI(1), IMPA1(1), INPPL1(1), ITPR1(1), ITPR2(5), ITPR3(2), PI4KA(1), PIK3C2G(2), PIK3C3(1), PIK3CA(2), PIK3CB(2), PIK3R1(2), PIP4K2B(2), PIP4K2C(1), PLCB1(1), PLCG1(1), PRKCA(1), PTEN(2), PTPMT1(1), SYNJ1(2)	6337689	36	17	36	6	4	13	8	6	4	1	0.0764	0.984	1.000
493	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	47	IMPA1(1), INPPL1(1), PI4KA(1), PIK3C3(1), PIK3CA(2), PIK3CB(2), PIP4K2B(2), PIP4K2C(1), PLCB1(1), PLCG1(1), PTEN(2), PTPMT1(1), SYNJ1(2)	3726648	18	12	18	4	3	7	3	2	3	0	0.304	0.984	1.000
494	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	85	BRAF(1), DAXX(2), ELK1(1), GRB2(1), MAP2K1(1), MAP3K11(1), MAP3K13(1), MAP3K2(1), MAP3K8(1), MAP4K3(1), MAPK12(1), MAPKAPK2(2), MEF2B(1), RPS6KA2(2), RPS6KA3(1), STAT1(1)	4864527	19	14	19	5	4	5	4	5	1	0	0.422	0.985	1.000
495	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(1), COL4A3(1), COL4A5(1), SLC23A2(1)	1318108	4	2	4	2	0	2	1	0	1	0	0.742	0.991	1.000
496	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CCNH(1), POLR3B(1), POLR3E(1), POLR3H(1), TAF6(1)	1738686	5	5	5	3	1	3	0	0	1	0	0.848	0.991	1.000
497	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	AICDA(1), AK3(1), CAD(3), PNPT1(1), POLA1(1), POLA2(1), POLE(5), POLE2(1), POLR3B(1), POLR3H(1), UPP1(1), UPP2(1), UPRT(1)	4103982	19	15	19	5	3	9	4	0	3	0	0.320	0.991	1.000
498	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(1), ASCC3(1), DDX19A(1), DDX52(1), DDX56(1), EP400(4), ERCC2(1), GANC(1), GUSB(1), GYS1(1), GYS2(1), HK2(1), MGAM(3), PYGB(1), PYGM(1), RAD54B(1), RAD54L(1), RUVBL2(1), SETX(1), SI(1), SMARCA2(1), SMARCA5(3), UGT1A9(1), UGT2B15(2), UGT2B17(1), UXS1(1)	6343820	34	18	34	9	8	11	5	2	8	0	0.420	0.991	1.000
499	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	65	CCR1(1), EDNRB(1), FPR1(1), MC3R(1), OPRD1(1), OPRK1(1), TACR2(1), TRHR(1)	2255257	8	7	8	5	2	3	1	0	2	0	0.870	0.991	1.000
500	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	32	ELK1(1), PPARA(1), TLR9(1)	1768830	3	2	3	3	0	1	0	1	1	0	0.960	0.992	1.000
501	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	PLD1(1), PTK2(1)	1346705	2	1	2	1	0	0	1	0	1	0	0.832	0.992	1.000
502	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS2(1), ADH6(1), ALDH3A1(1), DLD(1), FBP1(1), GALM(1), HK2(1), PFKL(1), PFKP(2), PKLR(1)	2905074	11	8	11	3	2	5	1	2	1	0	0.472	0.992	1.000
503	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F12(1), F5(1), F7(1), FGB(1), VWF(1)	1757617	5	5	5	3	3	2	0	0	0	0	0.830	0.992	1.000
504	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	NFATC2(1), PLCG1(1), SYT1(1)	1337842	3	3	3	2	0	2	1	0	0	0	0.874	0.993	1.000
505	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTN2(1), DMD(2), MYBPC3(1), MYH7(1), MYH8(1), MYOM1(3), NEB(3), TTN(9)	7122170	21	14	21	4	4	8	2	5	2	0	0.284	0.994	1.000
506	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ALDH3A1(1), DLD(1), HAGHL(1), ME1(1), ME3(1), PKLR(1)	1857692	6	6	6	5	0	3	0	2	1	0	0.961	0.994	1.000
507	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	63	CARD11(1), CD72(1), CR2(1), KRAS(2), NFATC2(1), NFKB2(2), PIK3CA(2), PIK3CB(2), PIK3R1(2), VAV3(1)	3696757	15	11	15	4	0	7	4	2	2	0	0.428	0.995	1.000
508	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	109	ACTN2(1), ARHGAP5(1), CDH5(2), CLDN1(1), CLDN16(2), CTNNA2(3), CTNNA3(1), CTNND1(1), CYBB(1), EZR(1), ICAM1(1), ITGA4(2), ITGAL(1), ITGB1(1), ITK(1), MAPK12(1), MLLT4(2), MMP9(1), MSN(3), PIK3CA(2), PIK3CB(2), PIK3R1(2), PLCG1(1), PRKCA(1), PTK2(1), ROCK1(2), SIPA1(1), TXK(1), VAV3(1), VCAM1(1)	6220901	42	17	41	8	4	20	10	4	4	0	0.0842	0.995	1.000
509	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	82	CDIPT(1), DGKA(2), DGKB(1), IMPA1(1), INPPL1(1), NEK3(1), PIK3C2G(2), PIK3CA(2), PIK3CB(2), PLCB1(1), PLCG1(1), PLK3(1), PRKCA(1), PRKCD(1), PRKCQ(1), PRKG1(1), RPS6KA2(2), RPS6KA3(1), STK11(1)	5795039	24	13	24	7	2	9	8	2	3	0	0.530	0.995	1.000
510	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	98	ADCY8(1), CAMK2B(1), CAMK2D(2), CAMK2G(1), CREB3L1(1), CREB3L4(1), DCT(1), EDNRB(1), EP300(3), FZD1(1), FZD10(1), FZD5(1), FZD8(1), GNAS(1), KIT(1), KRAS(2), MAP2K1(1), PLCB1(1), PRKCA(1), PRKX(1), TYR(1), WNT10B(1), WNT3A(1), WNT5A(1), WNT9A(1)	5263333	29	16	29	7	6	10	2	5	6	0	0.206	0.996	1.000
511	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	129	CADM1(1), CDH1(1), CDH2(1), CDH5(2), CLDN1(1), CLDN16(2), CNTN2(2), GLG1(4), HLA-A(1), HLA-B(5), HLA-DMA(1), HLA-DOA(1), HLA-DQA1(1), HLA-DRA(1), ICAM1(1), ICOSLG(1), ITGA4(2), ITGA6(1), ITGA8(1), ITGA9(2), ITGAL(1), ITGAV(1), ITGB1(1), ITGB7(1), ITGB8(1), NCAM1(1), NEO1(1), NFASC(1), NRCAM(1), NRXN1(1), PTPRC(1), PTPRF(1), PVR(1), PVRL3(1), SELL(2), SELP(1), SELPLG(1), VCAM1(1)	7374301	51	23	48	11	10	24	5	5	7	0	0.0419	0.996	1.000
512	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	BAD(1), CR2(1), GRB2(1), ITPR1(1), ITPR2(5), ITPR3(2), NFATC2(1), PIK3CA(2), PIK3R1(2), PPP1R13B(1), PTPRC(1), SOS1(1)	3641752	19	11	19	7	3	7	2	5	1	1	0.649	0.997	1.000
513	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(1), EP300(3), HDAC4(2), HDAC5(1), HDAC6(1)	2241246	8	6	8	3	2	3	2	1	0	0	0.676	0.997	1.000
514	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH6(1), ALDH3A1(1), DLD(1), FBP1(1), HK2(1), PFKP(2), PKLR(1)	2426745	8	6	8	3	2	3	0	2	1	0	0.676	0.997	1.000
515	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH6(1), ALDH3A1(1), DLD(1), FBP1(1), HK2(1), PFKP(2), PKLR(1)	2426745	8	6	8	3	2	3	0	2	1	0	0.676	0.997	1.000
516	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACOX1(1), ACSL3(1), ACSL5(1), ACSL6(1), CD36(1), CPT1C(1), GK2(1), ME1(1), PPARA(1), PPARD(1), RXRG(1), SCP2(1), SLC27A5(1), SORBS1(2)	3220856	15	12	15	5	3	5	2	4	1	0	0.623	0.998	1.000
517	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	DLD(1), FBP1(1), GOT1(1), HK2(1), PFKL(1), PFKP(2), PKLR(1)	2106815	8	6	8	4	3	3	1	1	0	0	0.766	0.998	1.000
518	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(1), COL4A3(1), COL4A5(1), F12(1), F5(1), FGB(1), PROS1(1)	2264518	7	6	7	6	2	3	1	0	1	0	0.950	0.998	1.000
519	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY8(1), AKAP1(1), AKAP11(1), GNA12(1), GNA15(1), ITPR1(1), KRAS(2), PDE1B(2), PDE1C(1), PDE4A(1), PDE4B(1), PRKCA(1), PRKCD(1), PRKCI(1), PRKCQ(1)	5774217	17	15	17	5	4	3	6	3	1	0	0.490	0.999	1.000
520	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	251	ACVR2A(1), CCL26(1), CCR1(1), CNTFR(1), CSF1(2), CSF1R(1), EGFR(1), FLT3(1), IFNGR1(1), IL10RA(1), IL12B(1), IL12RB2(2), IL22RA1(1), IL24(1), IL6ST(2), IL9R(1), INHBA(1), INHBB(1), KDR(2), KIT(1), PDGFRB(1), PF4V1(1), TGFBR2(1), TNFRSF10D(1), TNFRSF14(1), TNFRSF21(1), TNFSF13B(1)	8779353	31	20	30	7	6	15	7	1	2	0	0.140	0.999	1.000
521	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACB(1), ACSS2(1), ALDH3A1(1), DLD(1), HAGHL(1), ME1(1), ME3(1), PKLR(1)	2310148	8	8	8	5	0	5	0	2	1	0	0.900	0.999	1.000
522	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	83	ANPEP(1), CD36(1), CD59(1), CR2(1), CSF1(2), CSF1R(1), FLT3(1), HLA-DRA(1), IL9R(1), ITGA4(2), ITGA6(1), KIT(1), MME(2), THPO(2)	4186862	18	14	18	6	3	12	1	0	2	0	0.467	0.999	1.000
523	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	B3GNT2(1), FUT6(1), PIGS(2), ST6GALNAC3(1)	2418540	5	5	5	4	1	1	0	2	1	0	0.970	0.999	1.000
524	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	ALDH3A1(1), AOX1(2), CYP2D6(1), CYP2E1(1), CYP3A5(2), GCDH(1), HAAO(1), KYNU(1), MAOB(1)	2822193	11	6	11	6	1	3	1	2	3	1	0.972	0.999	1.000
525	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	50	ALOX15(1), CYP2E1(1), CYP4F3(1), GPX2(1), PLA2G1B(1), PTGS1(1)	2007800	6	5	6	4	1	2	1	1	1	0	0.940	0.999	1.000
526	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CLK3(1), DHX8(1), DHX9(1), DICER1(2), FUS(2), NONO(1), PPM1G(1), RBM5(1), RNPS1(1), SF3B1(3), SF3B2(1)	5368099	15	11	15	9	0	8	2	1	4	0	0.969	1.000	1.000
527	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	66	A2M(1), C1S(1), C2(1), C3(1), C7(1), CD59(1), CR2(1), F12(1), F13A1(2), F5(1), F7(1), FGB(1), PROS1(1), VWF(1)	4499748	15	11	15	7	5	7	1	0	2	0	0.734	1.000	1.000
528	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	89	ACVR1C(1), ACVR2A(1), BMP4(1), BMP5(1), BMP6(1), EP300(3), FST(1), INHBA(1), INHBB(1), LTBP1(1), RBL1(1), RBL2(1), ROCK1(2), SMAD5(1), SMURF1(1), TGFBR2(1), ZFYVE9(2)	4878768	21	10	21	8	3	7	5	5	1	0	0.716	1.000	1.000
529	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	233	ADRA2A(1), CALCR(2), CHRM2(1), CHRM3(1), CYSLTR1(1), DRD1(1), DRD5(1), EDNRB(1), FPR1(1), FSHB(1), GABBR1(1), GABRA1(1), GABRA2(1), GABRA4(2), GABRB3(2), GABRP(1), GLRA2(1), GLRA3(1), GRIA2(1), GRID1(1), GRIK2(2), GRIK5(1), GRIN1(1), GRIN2A(2), GRIN2D(3), GRM1(1), GRM3(2), GRM5(1), GRM6(1), GRM7(1), GRM8(1), HRH1(1), HRH2(1), HRH3(1), HTR1F(1), HTR5A(1), MC3R(1), NMUR1(1), NPFFR1(1), OPRD1(1), OPRK1(1), P2RY11(1), PARD3(1), PRSS1(1), PTGER2(1), PTGER4(1), RXFP1(1), TAAR8(1), TACR2(1), TBXA2R(1), TRHR(1)	10281605	59	25	59	16	16	23	10	3	7	0	0.0970	1.000	1.000
530	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	143	APC(4), BTRC(2), CAMK2B(1), CAMK2D(2), CAMK2G(1), CSNK1A1L(1), EP300(3), FOSL1(1), FZD1(1), FZD10(1), FZD5(1), FZD8(1), LRP5(1), LRP6(3), NFATC2(1), NKD1(1), PLCB1(1), PPARD(1), PRKCA(1), PRKX(1), ROCK1(2), SENP2(1), TP53(5), WNT10B(1), WNT3A(1), WNT5A(1), WNT9A(1)	7809454	41	24	41	10	6	16	4	6	8	1	0.232	1.000	1.000
531	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	92	ADCY8(1), DRD1(1), EGFR(1), GJA1(1), GNAS(1), GRB2(1), GRM1(1), GRM5(1), GUCY1A3(2), GUCY2C(1), GUCY2D(1), ITPR1(1), ITPR2(5), ITPR3(2), KRAS(2), MAP2K1(1), MAP3K2(1), NPR2(2), PDGFD(2), PDGFRB(1), PLCB1(1), PRKCA(1), PRKG1(1), PRKX(1), SOS1(1), TJP1(1), TUBA3D(1), TUBB1(1), TUBB2A(1)	6627439	38	22	38	11	8	15	4	7	3	1	0.285	1.000	1.000
532	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	127	EFNA5(1), EPHA2(4), EPHA7(2), EPHA8(1), ITGB1(1), KRAS(2), NFATC2(1), PLXNA2(1), PLXNB1(1), PLXNB2(1), PLXNB3(1), PTK2(1), RASA1(1), ROCK1(2), SEMA3D(2), SEMA4C(1), SEMA4F(1), SEMA4G(1), SEMA5A(1), SEMA5B(1), SEMA6A(1), SEMA6C(1), SEMA6D(2), SLIT2(1), UNC5A(1), UNC5B(2), UNC5D(2)	9630266	37	22	37	10	8	11	4	8	6	0	0.358	1.000	1.000
533	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	201	ACTN2(1), APC(4), ARAF(2), ARPC2(1), BAIAP2(1), BRAF(1), CHRM2(1), CHRM3(1), CRKL(1), CYFIP1(2), DIAPH3(2), DOCK1(1), EGFR(1), EZR(1), FGF16(1), FGFR2(1), FN1(2), GNA12(1), IQGAP1(1), IQGAP2(1), ITGA4(2), ITGA6(1), ITGA7(1), ITGA8(1), ITGA9(2), ITGAL(1), ITGAV(1), ITGAX(1), ITGB1(1), ITGB4(2), ITGB6(1), ITGB7(1), ITGB8(1), KRAS(2), MAP2K1(1), MSN(3), MYH10(1), MYH9(1), NCKAP1L(1), PDGFRB(1), PIK3CA(2), PIK3CB(2), PIK3R1(2), PIP4K2B(2), PIP4K2C(1), PPP1CB(1), PTK2(1), RDX(1), ROCK1(2), SOS1(1), SSH1(1), SSH3(1), VAV3(1), WASF2(1)	13888115	72	31	71	16	9	38	8	9	8	0	0.0472	1.000	1.000
534	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	247	ACVR1C(1), ATF4(1), BRAF(1), CACNA1A(1), CACNA1C(1), CACNA1D(1), CACNA1E(3), CACNA1F(1), CACNA1G(1), CACNA1I(1), CACNA2D2(1), CACNA2D4(1), CACNG4(1), CACNG5(1), CRKL(1), DAXX(2), EGFR(1), ELK1(1), FGF16(1), FGFR2(1), FLNA(1), FLNB(1), GNA12(1), GRB2(1), KRAS(2), MAP2K1(1), MAP3K13(1), MAP3K2(1), MAP3K8(1), MAP4K3(1), MAPK12(1), MAPKAPK2(2), NFATC2(1), NFKB2(2), NTF3(1), NTRK1(1), PDGFRB(1), PLA2G1B(1), PPP5C(1), PRKCA(1), PRKX(1), PTPRR(1), RAPGEF2(1), RASA1(1), RASGRP2(1), RPS6KA2(2), RPS6KA3(1), SOS1(1), STK3(1), TAOK3(1), TGFBR2(1), TP53(5)	14658259	63	28	63	15	11	27	10	5	9	1	0.0779	1.000	1.000
535	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	192	ACTB(1), ACTG1(1), ACTN2(1), ARHGAP5(1), BAD(1), BIRC2(2), BIRC3(1), BRAF(1), CAV1(1), COL11A1(1), COL4A1(1), COL6A1(1), COL6A3(4), COL6A6(1), CRKL(1), DOCK1(1), EGFR(1), ELK1(1), ERBB2(2), FARP2(1), FLNA(1), FLNB(1), FN1(2), GRB2(1), IBSP(1), IGF1R(1), ITGA4(2), ITGA6(1), ITGA7(1), ITGA8(1), ITGA9(2), ITGAV(1), ITGB1(1), ITGB4(2), ITGB6(1), ITGB7(1), ITGB8(1), KDR(2), LAMA1(2), LAMA2(1), LAMA3(2), LAMA4(3), LAMA5(1), LAMB3(2), MAP2K1(1), PDGFD(2), PDGFRB(1), PIK3CA(2), PIK3CB(2), PIK3R1(2), PPP1CB(1), PRKCA(1), PTEN(2), PTK2(1), ROCK1(2), SHC4(2), SOS1(1), TLN1(1), TLN2(1), TNC(1), VAV3(1), VWF(1), ZYX(2)	18669519	86	31	86	23	13	43	10	12	8	0	0.143	1.000	1.000
536	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	168	ADCY8(1), ATP2A3(1), ATP2B1(1), CACNA1A(1), CACNA1C(1), CACNA1D(1), CACNA1E(3), CACNA1F(1), CACNA1G(1), CACNA1I(1), CAMK2B(1), CAMK2D(2), CAMK2G(1), CHRM2(1), CHRM3(1), CYSLTR1(1), DRD1(1), EDNRB(1), EGFR(1), ERBB2(2), ERBB4(3), GNA15(1), GNAS(1), GRIN1(1), GRIN2A(2), GRIN2D(3), GRM1(1), GRM5(1), HRH1(1), HRH2(1), HTR5A(1), ITPR1(1), ITPR2(5), ITPR3(2), NOS1(2), NOS3(1), PDE1B(2), PDE1C(1), PDGFRB(1), PHKA1(3), PHKB(1), PLCB1(1), PLCG1(1), PRKCA(1), PRKX(1), RYR1(3), RYR3(5), SLC8A3(1), SPHK2(3), TACR2(1), TBXA2R(1), TRHR(1)	13526692	78	30	78	23	17	29	13	7	11	1	0.145	1.000	1.000
537	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	136	ACTB(1), ACTG1(1), COL11A1(1), COL17A1(1), COL4A1(1), COL6A1(1), COL6A3(4), COL6A6(1), FN1(2), GJA1(1), GJA10(1), GJA5(1), GJC1(1), GJD4(1), IBSP(1), ITGA6(1), ITGB4(2), KRT1(1), KRT10(1), KRT3(2), KRT7(1), KRT74(1), KRT8(1), KRT81(1), KRT85(1), LAMA1(2), LAMA2(1), LAMA3(2), LAMA4(3), LAMA5(1), LAMB3(2), LMNA(1), LMNB1(1), NES(1), TNC(1), VWF(1)	12436577	47	26	47	15	10	24	2	6	5	0	0.374	1.000	1.000
538	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	84	CD36(1), COL11A1(1), COL4A1(1), COL6A1(1), COL6A3(4), COL6A6(1), FN1(2), FNDC1(1), FNDC3A(1), HSPG2(1), IBSP(1), ITGA4(2), ITGA6(1), ITGA7(1), ITGA8(1), ITGA9(2), ITGAV(1), ITGB1(1), ITGB4(2), ITGB6(1), ITGB7(1), ITGB8(1), LAMA1(2), LAMA2(1), LAMA3(2), LAMA4(3), LAMA5(1), LAMB3(2), SV2C(1), TNC(1), VWF(1)	11140069	43	24	43	17	6	24	3	5	5	0	0.706	1.000	1.000
539	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ADCY8(1), ATF4(1), ATP2A3(1), CAMK2B(1), CAMK2D(2), CAMK2G(1), CORIN(1), GJA1(1), GRK5(1), GUCY1A3(2), ITPR1(1), ITPR2(5), ITPR3(2), NOS1(2), NOS3(1), PDE4B(1), PLCG1(1), PRKCA(1), PRKCD(1), PRKCQ(1), RAMP3(1), RGS20(1), RYR1(3), RYR3(5)	8758337	38	23	38	14	5	16	5	5	6	1	0.563	1.000	1.000
540	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADCY8(1), AK2(1), ALLC(2), AMPD1(1), GART(1), GMPR(1), GUCY1A3(2), GUCY2C(1), GUCY2D(1), NPR2(2), PDE1C(1), PDE3B(1), PDE4A(1), PDE4B(1), PDE9A(1), PKLR(1), PNPT1(1), POLA1(1), POLA2(1), POLE(5), POLE2(1), POLR3B(1), POLR3H(1), PRPS1(1)	8208462	31	20	31	12	6	14	4	2	5	0	0.594	1.000	1.000
541	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA10(1), ABCA12(1), ABCA13(5), ABCA6(1), ABCA7(1), ABCA8(1), ABCA9(1), ABCB1(1), ABCB11(1), ABCB5(2), ABCB7(1), ABCB8(1), ABCC1(1), ABCC12(1), ABCC2(2), ABCD1(1), ABCG2(1), CFTR(1), TAP1(2)	6004906	26	20	26	16	4	14	0	1	7	0	0.951	1.000	1.000
542	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY8(1), ATP2A3(1), ATP2B1(1), CACNA1A(1), CACNA1C(1), CACNA1D(1), CACNA1E(3), CAMK2B(1), CAMK2D(2), CAMK2G(1), CASQ1(1), CHRM2(1), CHRM3(1), GJA1(1), GJA5(1), GRK5(1), ITPR1(1), ITPR2(5), ITPR3(2), KCNB1(1), KCNJ5(1), PRKCA(1), PRKCD(1), PRKCQ(1), RGS20(1), RYR1(3), RYR3(5), SLC8A3(1)	9490430	42	19	42	16	8	19	5	4	5	1	0.558	1.000	1.000
543	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	75	ACTB(1), ACTG1(1), ACTN2(1), ACVR1C(1), BAIAP2(1), CDH1(1), CTNNA2(3), CTNNA3(1), CTNND1(1), EGFR(1), EP300(3), ERBB2(2), FARP2(1), IGF1R(1), IQGAP1(1), MLLT4(2), PARD3(1), PTPRF(1), PTPRJ(1), PVRL3(1), SORBS1(2), TGFBR2(1), TJP1(1), WASF2(1)	5996220	31	18	31	13	3	13	9	4	2	0	0.799	1.000	1.000
544	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	160	ADRA2A(1), CCR1(1), CHRM2(1), CHRM3(1), DRD1(1), DRD5(1), EDNRB(1), FPR1(1), GPR85(1), GPR87(1), HRH1(1), HRH2(1), HRH3(1), HTR1F(1), HTR5A(1), MC3R(1), NMUR1(1), OPRD1(1), OPRK1(1), OR1C1(1), OR8B8(1), P2RY11(1), PTGER2(1), PTGER4(1), TBXA2R(1), TRHR(1)	5242058	26	17	26	14	9	9	4	2	2	0	0.858	1.000	1.000
545	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADCY8(1), AK2(1), ALLC(2), AMPD1(1), ATP5G2(1), GART(1), GUCY1A3(2), GUCY2C(1), GUCY2D(1), NPR2(2), PDE4A(1), PDE4B(1), PDE6C(1), PDE9A(1), PKLR(1), POLB(1), POLE(5), PRPS1(1)	6402613	25	16	25	10	4	14	2	1	4	0	0.601	1.000	1.000
546	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	108	B3GNT2(1), B3GNT6(2), B4GALT5(1), EXTL3(1), GALNT11(1), GALNT14(1), GALNT4(2), GALNT5(1), GALNTL5(1), GCNT1(1), GCNT4(1), MAN1A2(1), MAN1C1(1), MGAT5B(1), NDST3(1), NDST4(1), ST6GAL1(1)	5467086	19	14	19	15	2	6	4	1	6	0	0.989	1.000	1.000
547	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	ADAM17(1), APH1A(1), DLL1(2), DTX1(1), EP300(3), JAG2(2), MAML3(1), NOTCH1(1), NOTCH2(2), NOTCH3(2), NOTCH4(2), PSEN2(1)	3439768	19	14	18	10	4	9	1	3	2	0	0.870	1.000	1.000
548	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	51	CELSR2(2), CHRM2(1), CHRM3(1), CIDEB(1), EMR3(1), GPR133(1), GRM1(1), P2RY11(1)	3023228	9	9	9	5	2	5	2	0	0	0	0.818	1.000	1.000
549	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	31	ADRA2A(1), CHRM2(1), CHRM3(1), DRD1(1), DRD5(1), HRH1(1), HRH2(1), HTR1F(1), HTR5A(1)	1109754	9	8	9	5	3	4	2	0	0	0	0.792	1.000	1.000
550	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	CAV1(1), KDR(2), NOS3(1), PDE3A(1), PDE3B(1), PRKG1(1), SYT1(1)	2080621	8	8	8	5	3	5	0	0	0	0	0.826	1.000	1.000
551	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	EPRS(1), FARSB(1), IARS(2), MTFMT(2), VARS(1)	2688846	7	7	7	6	2	3	1	1	0	0	0.977	1.000	1.000
552	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	BIN1(1), EPN1(1), SYNJ1(2), SYT1(1)	1139511	5	5	5	4	1	4	0	0	0	0	0.900	1.000	1.000
553	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(1), IL12B(1), ITGAX(1), TLR9(1)	856913	4	4	4	3	0	3	0	1	0	0	0.891	1.000	1.000
554	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	CMA1(1), COL4A1(1), COL4A3(1), COL4A5(1)	1320200	4	3	4	4	1	2	1	0	0	0	0.947	1.000	1.000
555	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	EPRS(1), IARS(2)	1578872	3	3	3	6	1	1	0	1	0	0	0.999	1.000	1.000
556	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	EP300(3), RARA(1)	978949	4	3	4	3	1	2	0	1	0	0	0.933	1.000	1.000
557	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGFR(1), MAP2K1(1), RARA(1)	866446	3	3	3	3	1	1	0	1	0	0	0.955	1.000	1.000
558	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	PFKL(1), PKLR(1)	464747	2	2	2	2	0	1	1	0	0	0	0.930	1.000	1.000
559	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARSB(1), GOT1(1)	439963	2	2	2	2	2	0	0	0	0	0	0.915	1.000	1.000
560	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	B3GNT2(1), FUT6(1)	783449	2	2	2	2	0	1	0	1	0	0	0.953	1.000	1.000
561	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	NOS3(1)	473784	1	1	1	3	0	1	0	0	0	0	0.997	1.000	1.000
562	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	TOP2A(1)	534742	1	1	1	2	0	1	0	0	0	0	0.987	1.000	1.000
563	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	16	DSE(1)	672046	1	1	1	2	1	0	0	0	0	0	0.968	1.000	1.000
564	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT2(1)	573599	1	1	1	4	0	0	0	1	0	0	0.998	1.000	1.000
565	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ME1(1)	475069	1	1	1	3	0	0	0	1	0	0	0.995	1.000	1.000
566	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	SNCAIP(1)	319745	1	1	1	3	0	1	0	0	0	0	0.995	1.000	1.000
567	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	GOT1(1)	401336	1	1	1	2	1	0	0	0	0	0	0.972	1.000	1.000
568	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	RARA(1)	1236249	1	1	1	7	1	0	0	0	0	0	1.000	1.000	1.000
569	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(1)	468039	1	1	1	2	0	1	0	0	0	0	0.976	1.000	1.000
570	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18		989974	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
571	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10		915760	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
572	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5		313180	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
573	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6		298656	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
574	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6		277845	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
575	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7		314019	0	0	0	2	0	0	0	0	0	0	1.000	1.000	1.000
576	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5		148590	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
577	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5		237066	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
578	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8		326108	0	0	0	3	0	0	0	0	0	0	1.000	1.000	1.000
579	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5		218537	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
580	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9		582548	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
581	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9		331411	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
582	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10		493265	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
583	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6		259845	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
584	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8		262821	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
585	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8		337768	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
586	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8		326108	0	0	0	3	0	0	0	0	0	0	1.000	1.000	1.000
587	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2		79188	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
588	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7		413665	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
589	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6		293768	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
590	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4		224067	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
591	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1		36548	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
592	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2		84488	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
593	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10		353244	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
594	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2		109845	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
595	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4		145880	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
596	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4		190977	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
597	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6		227008	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
598	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2		105539	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
599	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12		464417	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
600	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13		320421	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
601	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31		1482945	0	0	0	2	0	0	0	0	0	0	1.000	1.000	1.000
602	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5		180357	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
603	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5		243932	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
604	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	22		1202634	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
605	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8		241263	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
606	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4		443130	0	0	0	2	0	0	0	0	0	0	1.000	1.000	1.000
607	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14		666685	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
608	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7		569545	0	0	0	2	0	0	0	0	0	0	1.000	1.000	1.000
609	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4		313408	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
610	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11		490687	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
611	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6		253984	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
612	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7		300280	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
613	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6		161439	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
614	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3		57435	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
615	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4		172178	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
616	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7		291197	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
