GSEA Class2: Canonical Pathways enriched in each subtypes of mRNAseq_cNMF in KIRP-TP

Kidney Renal Papillary Cell Carcinoma (Primary solid tumor)

28 January 2016 | analyses__2016_01_28

Maintainer Information

Citation Information

Maintained by Juok Cho (Broad Institute)

Cite as Broad Institute TCGA Genome Data Analysis Center (2016): GSEA Class2: Canonical Pathways enriched in each subtypes of mRNAseq_cNMF in KIRP-TP. Broad Institute of MIT and Harvard. doi:10.7908/C1NP23TM

+ Overview

+ Introduction

+ Summary

Table 1. Get Full Table basic data info

basic data info
Number of Gene Sets: 707
Number of samples: 290
Original number of Gene Sets: 1320
Maximum gene set size: 933

Table 2. Get Full Table pheno data info

phenotype info
pheno.type: 1 - 5 :[ clus1 ] 32
pheno.type: 2 - 5 :[ clus2 ] 91
pheno.type: 3 - 5 :[ clus3 ] 71
pheno.type: 4 - 5 :[ clus4 ] 32
pheno.type: 5 - 5 :[ clus5 ] 64

For the expression subtypes of 17999 genes in 291 samples, GSEA found enriched gene sets in each cluster using 290 gene sets in MSigDB canonical pathways. Top enriched gene sets are listed as below.

clus1

Top enriched gene sets are KEGG FRUCTOSE AND MANNOSE METABOLISM, KEGG O GLYCAN BIOSYNTHESIS, KEGG AMINO SUGAR AND NUCLEOTIDE SUGAR METABOLISM, KEGG GLYCEROPHOSPHOLIPID METABOLISM, KEGG ETHER LIPID METABOLISM, KEGG ARACHIDONIC ACID METABOLISM, KEGG MAPK SIGNALING PATHWAY, KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION, KEGG CHEMOKINE SIGNALING PATHWAY, KEGG SNARE INTERACTIONS IN VESICULAR TRANSPORT

And common core enriched genes are AP1B1, AP1S2, CTSB, CTSK, CTSL1, CTSS, LGMN, CD4, FOS, ABCB9

clus2

Top enriched gene sets are KEGG HISTIDINE METABOLISM, KEGG SNARE INTERACTIONS IN VESICULAR TRANSPORT, KEGG HEDGEHOG SIGNALING PATHWAY, KEGG TIGHT JUNCTION, KEGG TASTE TRANSDUCTION, BIOCARTA ALK PATHWAY, BIOCARTA DEATH PATHWAY, PID HDAC CLASSI PATHWAY, PID BMPPATHWAY, REACTOME SIGNALING BY FGFR1 MUTANTS

And common core enriched genes are CLDN15, CLDN18, CLDN19, CLDN20, CLDN3, CLDN6, CLDN7, CLDN9, SMAD7, GNAI1

clus3

Top enriched gene sets are KEGG GLYCOLYSIS GLUCONEOGENESIS, KEGG CITRATE CYCLE TCA CYCLE, KEGG PENTOSE PHOSPHATE PATHWAY, KEGG PENTOSE AND GLUCURONATE INTERCONVERSIONS, KEGG FRUCTOSE AND MANNOSE METABOLISM, KEGG FATTY ACID METABOLISM, KEGG STEROID HORMONE BIOSYNTHESIS, KEGG OXIDATIVE PHOSPHORYLATION, KEGG PYRIMIDINE METABOLISM, KEGG ALANINE ASPARTATE AND GLUTAMATE METABOLISM

And common core enriched genes are EHHADH, PIPOX, AARS, CARS2, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB

clus4

Top enriched gene sets are KEGG N GLYCAN BIOSYNTHESIS, KEGG O GLYCAN BIOSYNTHESIS, KEGG GLYCOSAMINOGLYCAN BIOSYNTHESIS HEPARAN SULFATE, KEGG GLYCOSPHINGOLIPID BIOSYNTHESIS LACTO AND NEOLACTO SERIES, KEGG BASAL TRANSCRIPTION FACTORS, KEGG MAPK SIGNALING PATHWAY, KEGG ERBB SIGNALING PATHWAY, KEGG CALCIUM SIGNALING PATHWAY, KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION, KEGG CHEMOKINE SIGNALING PATHWAY

And common core enriched genes are PIK3CA, PIK3CG, HDAC1, CCND1, MAPK8, SHC3, SHC4, EP300, HIF1A, BIRC3

clus5

Top enriched gene sets are KEGG OOCYTE MEIOSIS, KEGG UBIQUITIN MEDIATED PROTEOLYSIS, KEGG ADHERENS JUNCTION, KEGG THYROID CANCER, BIOCARTA MPR PATHWAY, BIOCARTA VEGF PATHWAY, PID AURORA B PATHWAY, PID DELTANP63PATHWAY, PID AURORA A PATHWAY, REACTOME CELL CYCLE

And common core enriched genes are EIF4B, EIF4E, CDH1, LEF1, MYC, RET, RXRA, RXRG, TCF7L1, ADCY1

+ Results

+ Subtype clus1 enriched pathways

Table 3. Get Full Table This table shows top 10 pathways which are significantly enriched in cluster clus1. It displays only significant gene sets satisfying nom.p.val.threshold (-1), fwer.p.val.threshold (-1) , fdr.q.val.threshold (0.25) and the default table is sorted by Normalized Enrichment Score (NES). Further details on NES statistics, please visit The Broad GSEA website.

GeneSet(GS)	Size(#genes)	genes.ES.table	ES	NES	NOM.p.val	FDR.q.val	FWER.p.val	Tag..	Gene..	Signal	FDR..median.	glob.p.val
KEGG FRUCTOSE AND MANNOSE METABOLISM	33	genes.ES.table	0.46	1.4	0.11	0.22	0.98	0.48	0.31	0.34	0.17	0.001
KEGG O GLYCAN BIOSYNTHESIS	29	genes.ES.table	0.55	1.5	0.025	0.14	0.94	0.34	0.15	0.29	0.1	0.001
KEGG AMINO SUGAR AND NUCLEOTIDE SUGAR METABOLISM	44	genes.ES.table	0.54	1.8	0.0041	0.058	0.6	0.36	0.24	0.28	0.02	0.002
KEGG GLYCEROPHOSPHOLIPID METABOLISM	70	genes.ES.table	0.38	1.4	0.033	0.2	0.97	0.27	0.23	0.21	0.15	0.001
KEGG ETHER LIPID METABOLISM	27	genes.ES.table	0.61	1.7	0.0041	0.074	0.74	0.37	0.23	0.29	0.034	0
KEGG ARACHIDONIC ACID METABOLISM	50	genes.ES.table	0.55	1.4	0.054	0.21	0.97	0.28	0.11	0.25	0.16	0.001
KEGG MAPK SIGNALING PATHWAY	243	genes.ES.table	0.38	1.4	0.057	0.23	0.98	0.21	0.15	0.18	0.18	0.002
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION	231	genes.ES.table	0.7	1.7	0	0.064	0.66	0.57	0.16	0.48	0.026	0.002
KEGG CHEMOKINE SIGNALING PATHWAY	183	genes.ES.table	0.72	1.9	0	0.056	0.25	0.41	0.12	0.36	0	0.009
KEGG SNARE INTERACTIONS IN VESICULAR TRANSPORT	38	genes.ES.table	0.35	1.4	0.12	0.25	0.99	0.21	0.24	0.16	0.2	0.002

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	DNASE2B	DNASE2B	DNASE2B	28	0.71	0.056	YES
2	ATP6V0D2	ATP6V0D2	ATP6V0D2	66	0.65	0.11	YES
3	CTSK	CTSK	CTSK	254	0.49	0.14	YES
4	CTSS	CTSS	CTSS	349	0.45	0.17	YES
5	SLC11A1	SLC11A1	SLC11A1	605	0.37	0.18	YES
6	CTSG	CTSG	CTSG	712	0.35	0.2	YES
7	ACP5	ACP5	ACP5	763	0.33	0.23	YES
8	AP1S2	AP1S2	AP1S2	811	0.32	0.25	YES
9	CTSW	CTSW	CTSW	837	0.32	0.28	YES
10	LAPTM5	LAPTM5	LAPTM5	846	0.31	0.3	YES
11	CTSE	CTSE	CTSE	964	0.29	0.32	YES
12	CD68	CD68	CD68	1150	0.26	0.33	YES
13	LIPA	LIPA	LIPA	1199	0.25	0.34	YES
14	CTSZ	CTSZ	CTSZ	1326	0.23	0.36	YES
15	LGMN	LGMN	LGMN	1407	0.22	0.37	YES
16	GM2A	GM2A	GM2A	1449	0.22	0.38	YES
17	MCOLN1	MCOLN1	MCOLN1	1520	0.21	0.4	YES
18	ARSG	ARSG	ARSG	1555	0.21	0.41	YES
19	FUCA1	FUCA1	FUCA1	1623	0.2	0.42	YES
20	LAMP3	LAMP3	LAMP3	2257	0.15	0.4	YES
21	CTSD	CTSD	CTSD	2346	0.14	0.41	YES
22	CTSF	CTSF	CTSF	2560	0.13	0.4	YES
23	NAPSA	NAPSA	NAPSA	2567	0.13	0.42	YES
24	PLA2G15	PLA2G15	PLA2G15	2651	0.12	0.42	YES
25	ATP6V0A4	ATP6V0A4	ATP6V0A4	2686	0.12	0.43	YES
26	TCIRG1	TCIRG1	TCIRG1	2702	0.12	0.44	YES
27	DNASE2	DNASE2	DNASE2	2769	0.12	0.44	YES
28	NPC2	NPC2	NPC2	2799	0.12	0.45	YES
29	AP1B1	AP1B1	AP1B1	2808	0.12	0.46	YES
30	CTSB	CTSB	CTSB	2828	0.11	0.47	YES
31	ACP2	ACP2	ACP2	2853	0.11	0.48	YES
32	GAA	GAA	GAA	2858	0.11	0.48	YES
33	CTSL1	CTSL1	CTSL1	2895	0.11	0.49	YES
34	MAN2B1	MAN2B1	MAN2B1	2922	0.11	0.5	YES
35	CTSH	CTSH	CTSH	3019	0.1	0.5	YES
36	GALC	GALC	GALC	3052	0.1	0.51	YES
37	PSAP	PSAP	PSAP	3100	0.1	0.51	YES
38	GALNS	GALNS	GALNS	3128	0.1	0.52	YES
39	SUMF1	SUMF1	SUMF1	3235	0.096	0.52	YES
40	NEU1	NEU1	NEU1	3257	0.096	0.53	YES
41	HEXB	HEXB	HEXB	3262	0.095	0.54	YES
42	AP4B1	AP4B1	AP4B1	3313	0.093	0.54	YES
43	PPT1	PPT1	PPT1	3547	0.084	0.54	YES
44	ARSA	ARSA	ARSA	3584	0.083	0.54	YES
45	HEXA	HEXA	HEXA	3586	0.082	0.55	YES
46	GLB1	GLB1	GLB1	3616	0.082	0.55	YES
47	MANBA	MANBA	MANBA	3624	0.081	0.56	YES
48	ATP6V0D1	ATP6V0D1	ATP6V0D1	3654	0.08	0.56	YES
49	GUSB	GUSB	GUSB	3660	0.08	0.57	YES
50	GGA1	GGA1	GGA1	3703	0.079	0.57	YES
51	HYAL1	HYAL1	HYAL1	3749	0.077	0.58	YES
52	ASAH1	ASAH1	ASAH1	3782	0.076	0.58	YES
53	GLA	GLA	GLA	3787	0.076	0.59	YES
54	ARSB	ARSB	ARSB	3788	0.076	0.59	YES
55	CLTCL1	CLTCL1	CLTCL1	3815	0.074	0.6	YES
56	SMPD1	SMPD1	SMPD1	3897	0.072	0.6	YES
57	NAGLU	NAGLU	NAGLU	3950	0.07	0.6	YES
58	CTSA	CTSA	CTSA	4054	0.067	0.6	YES
59	NAGPA	NAGPA	NAGPA	4078	0.067	0.6	YES
60	ATP6V0A1	ATP6V0A1	ATP6V0A1	4133	0.066	0.61	YES
61	GNS	GNS	GNS	4178	0.064	0.61	YES
62	PPT2	PPT2	PPT2	4316	0.06	0.61	YES
63	TPP1	TPP1	TPP1	4378	0.059	0.61	YES
64	CTSC	CTSC	CTSC	4442	0.057	0.61	YES
65	GBA	GBA	GBA	4453	0.057	0.61	YES
66	NAGA	NAGA	NAGA	4480	0.056	0.62	YES
67	AP3B2	AP3B2	AP3B2	4487	0.056	0.62	YES
68	CTSL2	CTSL2	CTSL2	4605	0.054	0.62	YES
69	ATP6V0B	ATP6V0B	ATP6V0B	4644	0.053	0.62	YES
70	ATP6V0C	ATP6V0C	ATP6V0C	4699	0.052	0.62	YES
71	ABCB9	ABCB9	ABCB9	4702	0.052	0.63	YES
72	NPC1	NPC1	NPC1	4714	0.052	0.63	YES
73	CD63	CD63	CD63	4767	0.05	0.63	YES
74	M6PR	M6PR	M6PR	4778	0.05	0.63	YES
75	GGA2	GGA2	GGA2	4879	0.048	0.63	YES
76	LAMP1	LAMP1	LAMP1	4958	0.047	0.63	YES
77	IDUA	IDUA	IDUA	5083	0.045	0.63	YES
78	CTSO	CTSO	CTSO	5139	0.044	0.63	YES
79	SGSH	SGSH	SGSH	5155	0.044	0.63	YES
80	GGA3	GGA3	GGA3	5157	0.044	0.64	YES
81	AP3S1	AP3S1	AP3S1	5228	0.042	0.63	NO
82	GNPTG	GNPTG	GNPTG	5408	0.04	0.63	NO
83	LAPTM4A	LAPTM4A	LAPTM4A	5791	0.034	0.61	NO
84	GNPTAB	GNPTAB	GNPTAB	5898	0.033	0.61	NO
85	SORT1	SORT1	SORT1	5996	0.031	0.6	NO
86	ATP6AP1	ATP6AP1	ATP6AP1	6024	0.031	0.6	NO
87	CLN5	CLN5	CLN5	6255	0.028	0.59	NO
88	ENTPD4	ENTPD4	ENTPD4	6315	0.028	0.59	NO
89	ATP6V1H	ATP6V1H	ATP6V1H	6480	0.026	0.58	NO
90	LAMP2	LAMP2	LAMP2	6714	0.024	0.57	NO
91	CLN3	CLN3	CLN3	6897	0.022	0.56	NO
92	AP4M1	AP4M1	AP4M1	7099	0.019	0.56	NO
93	AGA	AGA	AGA	7162	0.019	0.55	NO
94	CTNS	CTNS	CTNS	7245	0.018	0.55	NO
95	AP1S1	AP1S1	AP1S1	7356	0.017	0.55	NO
96	AP4S1	AP4S1	AP4S1	7436	0.016	0.54	NO
97	CLTB	CLTB	CLTB	7746	0.013	0.53	NO
98	AP3S2	AP3S2	AP3S2	7917	0.012	0.52	NO
99	IGF2R	IGF2R	IGF2R	7987	0.011	0.52	NO
100	AP4E1	AP4E1	AP4E1	8167	0.0089	0.5	NO
101	LAPTM4B	LAPTM4B	LAPTM4B	8376	0.007	0.49	NO
102	CLTA	CLTA	CLTA	8469	0.0061	0.49	NO
103	SCARB2	SCARB2	SCARB2	9073	0.00055	0.46	NO
104	ATP6V0A2	ATP6V0A2	ATP6V0A2	9247	-0.00097	0.45	NO
105	AP1G1	AP1G1	AP1G1	9416	-0.0027	0.44	NO
106	CLTC	CLTC	CLTC	9891	-0.0068	0.41	NO
107	AP1S3	AP1S3	AP1S3	10115	-0.0089	0.4	NO
108	SLC11A2	SLC11A2	SLC11A2	10183	-0.0096	0.4	NO
109	HGSNAT	HGSNAT	HGSNAT	10295	-0.011	0.39	NO
110	AP3B1	AP3B1	AP3B1	10319	-0.011	0.39	NO
111	AP3M1	AP3M1	AP3M1	11089	-0.018	0.35	NO
112	AP1M1	AP1M1	AP1M1	12213	-0.03	0.29	NO
113	AP3D1	AP3D1	AP3D1	12350	-0.032	0.28	NO
114	IDS	IDS	IDS	12670	-0.036	0.27	NO
115	CD164	CD164	CD164	12894	-0.038	0.26	NO
116	AP1M2	AP1M2	AP1M2	13613	-0.049	0.22	NO
117	MFSD8	MFSD8	MFSD8	14235	-0.059	0.19	NO
118	ABCA2	ABCA2	ABCA2	14292	-0.06	0.2	NO
119	SLC17A5	SLC17A5	SLC17A5	14859	-0.072	0.17	NO
120	AP3M2	AP3M2	AP3M2	14989	-0.076	0.17	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	NCF1C	NCF1C	NCF1C	10	0.77	0.19	YES
2	FPR1	FPR1	FPR1	113	0.58	0.32	YES
3	NCF2	NCF2	NCF2	166	0.54	0.45	YES
4	CAMK1G	CAMK1G	CAMK1G	188	0.52	0.58	YES
5	GNA15	GNA15	GNA15	383	0.44	0.67	YES
6	NFATC4	NFATC4	NFATC4	2766	0.12	0.57	NO
7	NFATC1	NFATC1	NFATC1	3354	0.092	0.56	NO
8	GNGT1	GNGT1	GNGT1	3615	0.082	0.56	NO
9	NFATC3	NFATC3	NFATC3	3887	0.072	0.56	NO
10	NFKBIA	NFKBIA	NFKBIA	3904	0.072	0.58	NO
11	CAMK1	CAMK1	CAMK1	4197	0.064	0.58	NO
12	MAP2K3	MAP2K3	MAP2K3	4942	0.048	0.55	NO
13	NFATC2	NFATC2	NFATC2	5493	0.038	0.53	NO
14	PAK1	PAK1	PAK1	5556	0.038	0.54	NO
15	CALM3	CALM3	CALM3	5575	0.037	0.54	NO
16	RAC1	RAC1	RAC1	5724	0.035	0.54	NO
17	NFKB1	NFKB1	NFKB1	6143	0.03	0.53	NO
18	MAPK3	MAPK3	MAPK3	6174	0.029	0.53	NO
19	RAF1	RAF1	RAF1	6729	0.023	0.51	NO
20	MAPK14	MAPK14	MAPK14	7042	0.02	0.5	NO
21	CALM2	CALM2	CALM2	7677	0.014	0.46	NO
22	PPP3CB	PPP3CB	PPP3CB	7712	0.014	0.46	NO
23	GNB1	GNB1	GNB1	7779	0.013	0.46	NO
24	RELA	RELA	RELA	8154	0.0091	0.44	NO
25	PPP3CC	PPP3CC	PPP3CC	8478	0.006	0.43	NO
26	MAP2K1	MAP2K1	MAP2K1	8849	0.0025	0.41	NO
27	PPP3CA	PPP3CA	PPP3CA	9618	-0.0044	0.37	NO
28	MAPK1	MAPK1	MAPK1	10282	-0.01	0.33	NO
29	MAP3K1	MAP3K1	MAP3K1	10703	-0.014	0.31	NO
30	MAP2K2	MAP2K2	MAP2K2	10729	-0.015	0.32	NO
31	CALM1	CALM1	CALM1	11950	-0.027	0.25	NO
32	HRAS	HRAS	HRAS	12133	-0.029	0.25	NO
33	MAP2K6	MAP2K6	MAP2K6	12493	-0.033	0.24	NO
34	ELK1	ELK1	ELK1	13018	-0.04	0.22	NO
35	PLCB1	PLCB1	PLCB1	16048	-0.11	0.077	NO
36	PIK3C2G	PIK3C2G	PIK3C2G	16390	-0.13	0.089	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	CR1	CR1	CR1	4	0.83	0.028	YES
2	MEFV	MEFV	MEFV	43	0.69	0.048	YES
3	CFD	CFD	CFD	49	0.68	0.071	YES
4	NLRC4	NLRC4	NLRC4	67	0.65	0.091	YES
5	CD180	CD180	CD180	77	0.63	0.11	YES
6	TLR8	TLR8	TLR8	101	0.59	0.13	YES
7	TLR7	TLR7	TLR7	131	0.56	0.15	YES
8	LY86	LY86	LY86	145	0.56	0.16	YES
9	ZBP1	ZBP1	ZBP1	194	0.52	0.18	YES
10	NOD2	NOD2	NOD2	218	0.5	0.2	YES
11	SAA1	SAA1	SAA1	224	0.5	0.21	YES
12	BTK	BTK	BTK	245	0.49	0.23	YES
13	CTSK	CTSK	CTSK	254	0.49	0.24	YES
14	RIPK3	RIPK3	RIPK3	258	0.49	0.26	YES
15	LY96	LY96	LY96	270	0.48	0.28	YES
16	NLRP3	NLRP3	NLRP3	273	0.48	0.29	YES
17	C4BPA	C4BPA	C4BPA	299	0.47	0.3	YES
18	CFH	CFH	CFH	338	0.45	0.32	YES
19	CTSS	CTSS	CTSS	349	0.45	0.33	YES
20	PSTPIP1	PSTPIP1	PSTPIP1	358	0.44	0.35	YES
21	C2	C2	C2	394	0.43	0.36	YES
22	CCR2	CCR2	CCR2	437	0.42	0.37	YES
23	C1QB	C1QB	C1QB	538	0.39	0.38	YES
24	DEFA1B	DEFA1B	DEFA1B	563	0.38	0.39	YES
25	IRAK3	IRAK3	IRAK3	574	0.38	0.4	YES
26	TLR5	TLR5	TLR5	606	0.37	0.41	YES
27	C1QA	C1QA	C1QA	615	0.37	0.42	YES
28	CD4	CD4	CD4	652	0.36	0.43	YES
29	C1QC	C1QC	C1QC	657	0.36	0.45	YES
30	TLR6	TLR6	TLR6	674	0.36	0.46	YES
31	CARD9	CARD9	CARD9	689	0.35	0.47	YES
32	CD14	CD14	CD14	692	0.35	0.48	YES
33	S100A12	S100A12	S100A12	705	0.35	0.49	YES
34	CASP1	CASP1	CASP1	754	0.34	0.5	YES
35	C3	C3	C3	765	0.33	0.51	YES
36	C1S	C1S	C1S	782	0.33	0.52	YES
37	P2RX7	P2RX7	P2RX7	802	0.32	0.53	YES
38	TLR1	TLR1	TLR1	851	0.31	0.54	YES
39	TLR4	TLR4	TLR4	932	0.29	0.54	YES
40	FOS	FOS	FOS	1040	0.27	0.55	YES
41	AIM2	AIM2	AIM2	1053	0.27	0.55	YES
42	DEFB1	DEFB1	DEFB1	1090	0.26	0.56	YES
43	BIRC3	BIRC3	BIRC3	1133	0.26	0.57	YES
44	TLR2	TLR2	TLR2	1146	0.26	0.57	YES
45	NLRP1	NLRP1	NLRP1	1173	0.25	0.58	YES
46	PYCARD	PYCARD	PYCARD	1248	0.24	0.59	YES
47	S100B	S100B	S100B	1327	0.23	0.59	YES
48	TLR10	TLR10	TLR10	1354	0.23	0.6	YES
49	LBP	LBP	LBP	1358	0.23	0.6	YES
50	RNF125	RNF125	RNF125	1365	0.23	0.61	YES
51	CFB	CFB	CFB	1377	0.23	0.62	YES
52	TLR9	TLR9	TLR9	1406	0.22	0.62	YES
53	LGMN	LGMN	LGMN	1407	0.22	0.63	YES
54	CFHR3	CFHR3	CFHR3	1518	0.21	0.63	YES
55	TNFAIP3	TNFAIP3	TNFAIP3	1720	0.19	0.63	YES
56	TICAM2	TICAM2	TICAM2	1750	0.19	0.63	YES
57	CCR6	CCR6	CCR6	2115	0.16	0.62	YES
58	MAPK11	MAPK11	MAPK11	2307	0.14	0.61	YES
59	C4A	C4A	C4A	2316	0.14	0.62	YES
60	NLRC5	NLRC5	NLRC5	2412	0.14	0.61	YES
61	MASP1	MASP1	MASP1	2429	0.14	0.62	YES
62	MAPK13	MAPK13	MAPK13	2430	0.14	0.62	YES
63	RPS6KA2	RPS6KA2	RPS6KA2	2540	0.13	0.62	YES
64	UNC93B1	UNC93B1	UNC93B1	2552	0.13	0.62	YES
65	CASP4	CASP4	CASP4	2592	0.13	0.63	YES
66	RPS6KA5	RPS6KA5	RPS6KA5	2618	0.12	0.63	YES
67	IRF1	IRF1	IRF1	2628	0.12	0.63	YES
68	C6	C6	C6	2676	0.12	0.63	YES
69	UBA7	UBA7	UBA7	2735	0.12	0.63	YES
70	ISG15	ISG15	ISG15	2748	0.12	0.64	YES
71	UBE2L6	UBE2L6	UBE2L6	2770	0.12	0.64	YES
72	CTSB	CTSB	CTSB	2828	0.11	0.64	YES
73	C7	C7	C7	2837	0.11	0.64	YES
74	C4BPB	C4BPB	C4BPB	2854	0.11	0.65	YES
75	CTSL1	CTSL1	CTSL1	2895	0.11	0.65	YES
76	CNPY3	CNPY3	CNPY3	3083	0.1	0.64	YES
77	LGALS3	LGALS3	LGALS3	3103	0.1	0.64	YES
78	PELI1	PELI1	PELI1	3111	0.1	0.65	YES
79	JUN	JUN	JUN	3209	0.097	0.64	YES
80	DEFB103B	DEFB103B	DEFB103B	3223	0.096	0.65	YES
81	MYD88	MYD88	MYD88	3280	0.095	0.65	YES
82	CFI	CFI	CFI	3303	0.094	0.65	YES
83	PROS1	PROS1	PROS1	3361	0.092	0.65	YES
84	TXNIP	TXNIP	TXNIP	3404	0.09	0.65	YES
85	RIPK2	RIPK2	RIPK2	3496	0.086	0.65	NO
86	MEF2C	MEF2C	MEF2C	3568	0.083	0.65	NO
87	RPS6KA1	RPS6KA1	RPS6KA1	3810	0.075	0.64	NO
88	IRAK2	IRAK2	IRAK2	3874	0.072	0.63	NO
89	NFKBIA	NFKBIA	NFKBIA	3904	0.072	0.64	NO
90	C9	C9	C9	3971	0.069	0.63	NO
91	AGER	AGER	AGER	4037	0.068	0.63	NO
92	IRF7	IRF7	IRF7	4069	0.067	0.63	NO
93	IKBKE	IKBKE	IKBKE	4082	0.067	0.63	NO
94	HERC5	HERC5	HERC5	4290	0.061	0.62	NO
95	DHX58	DHX58	DHX58	4364	0.059	0.62	NO
96	NOD1	NOD1	NOD1	4497	0.056	0.62	NO
97	CYLD	CYLD	CYLD	4560	0.055	0.62	NO
98	MBL2	MBL2	MBL2	4564	0.055	0.62	NO
99	TLR3	TLR3	TLR3	4569	0.055	0.62	NO
100	IRAK4	IRAK4	IRAK4	4658	0.053	0.62	NO
101	PLCG2	PLCG2	PLCG2	4673	0.052	0.62	NO
102	NFKB2	NFKB2	NFKB2	4710	0.052	0.62	NO
103	MAPK7	MAPK7	MAPK7	4737	0.051	0.62	NO
104	MAP2K3	MAP2K3	MAP2K3	4942	0.048	0.61	NO
105	NLRX1	NLRX1	NLRX1	5033	0.046	0.6	NO
106	DUSP4	DUSP4	DUSP4	5069	0.045	0.6	NO
107	CD55	CD55	CD55	5539	0.038	0.58	NO
108	UBE2D1	UBE2D1	UBE2D1	5586	0.037	0.58	NO
109	CASP10	CASP10	CASP10	5725	0.035	0.57	NO
110	IRF3	IRF3	IRF3	5825	0.034	0.56	NO
111	TRAF2	TRAF2	TRAF2	5960	0.032	0.56	NO
112	IKBKG	IKBKG	IKBKG	5982	0.032	0.56	NO
113	IKBKB	IKBKB	IKBKB	6018	0.031	0.56	NO
114	CRP	CRP	CRP	6023	0.031	0.56	NO
115	IRF2	IRF2	IRF2	6081	0.03	0.56	NO
116	HSP90B1	HSP90B1	HSP90B1	6135	0.03	0.55	NO
117	MAPK3	MAPK3	MAPK3	6174	0.029	0.55	NO
118	BCL2L1	BCL2L1	BCL2L1	6177	0.029	0.55	NO
119	DDOST	DDOST	DDOST	6265	0.028	0.55	NO
120	FADD	FADD	FADD	6484	0.026	0.54	NO
121	CAPZA1	CAPZA1	CAPZA1	6517	0.026	0.54	NO
122	UBA52	UBA52	UBA52	6549	0.025	0.54	NO
123	RNF135	RNF135	RNF135	6655	0.024	0.53	NO
124	OTUD5	OTUD5	OTUD5	7001	0.02	0.51	NO
125	MAPK14	MAPK14	MAPK14	7042	0.02	0.51	NO
126	IFNA1	IFNA1	IFNA1	7109	0.019	0.51	NO
127	ECSIT	ECSIT	ECSIT	7157	0.019	0.51	NO
128	ATG12	ATG12	ATG12	7241	0.018	0.5	NO
129	ZFYVE20	ZFYVE20	ZFYVE20	7272	0.018	0.5	NO
130	NFKBIB	NFKBIB	NFKBIB	7480	0.016	0.49	NO
131	IRAK1	IRAK1	IRAK1	7543	0.015	0.49	NO
132	RIPK1	RIPK1	RIPK1	7600	0.015	0.48	NO
133	TAB1	TAB1	TAB1	7601	0.015	0.48	NO
134	RPS27A	RPS27A	RPS27A	7758	0.013	0.48	NO
135	CASP9	CASP9	CASP9	7846	0.012	0.47	NO
136	TRAF3	TRAF3	TRAF3	8056	0.01	0.46	NO
137	RELA	RELA	RELA	8154	0.0091	0.46	NO
138	MAPKAPK3	MAPKAPK3	MAPKAPK3	8303	0.0076	0.45	NO
139	PIN1	PIN1	PIN1	8344	0.0073	0.44	NO
140	CASP8	CASP8	CASP8	8414	0.0066	0.44	NO
141	UBE2D2	UBE2D2	UBE2D2	8417	0.0066	0.44	NO
142	TANK	TANK	TANK	8524	0.0055	0.44	NO
143	TAB2	TAB2	TAB2	8549	0.0052	0.43	NO
144	UBE2N	UBE2N	UBE2N	8628	0.0045	0.43	NO
145	BCL2	BCL2	BCL2	8744	0.0036	0.42	NO
146	TBK1	TBK1	TBK1	8760	0.0034	0.42	NO
147	MAP2K1	MAP2K1	MAP2K1	8849	0.0025	0.42	NO
148	PIK3R4	PIK3R4	PIK3R4	8859	0.0024	0.42	NO
149	MAP2K4	MAP2K4	MAP2K4	8930	0.0018	0.41	NO
150	DAK	DAK	DAK	9006	0.0011	0.41	NO
151	UBE2D3	UBE2D3	UBE2D3	9044	0.00078	0.41	NO
152	TXN	TXN	TXN	9340	-0.0019	0.39	NO
153	DUSP7	DUSP7	DUSP7	9406	-0.0025	0.39	NO
154	ATG5	ATG5	ATG5	9646	-0.0047	0.37	NO
155	PRKCSH	PRKCSH	PRKCSH	9865	-0.0067	0.36	NO
156	APP	APP	APP	10072	-0.0085	0.35	NO
157	PPP2CB	PPP2CB	PPP2CB	10080	-0.0086	0.35	NO
158	BIRC2	BIRC2	BIRC2	10138	-0.0091	0.35	NO
159	CAPZA2	CAPZA2	CAPZA2	10247	-0.01	0.34	NO
160	MAPK1	MAPK1	MAPK1	10282	-0.01	0.34	NO
161	PIK3C3	PIK3C3	PIK3C3	10539	-0.013	0.33	NO
162	PPP2CA	PPP2CA	PPP2CA	10590	-0.013	0.32	NO
163	MAP3K1	MAP3K1	MAP3K1	10703	-0.014	0.32	NO
164	MAP2K2	MAP2K2	MAP2K2	10729	-0.015	0.32	NO
165	HSP90AB1	HSP90AB1	HSP90AB1	10773	-0.015	0.32	NO
166	TRAF6	TRAF6	TRAF6	10909	-0.016	0.31	NO
167	TICAM1	TICAM1	TICAM1	11027	-0.017	0.3	NO
168	RPS6KA3	RPS6KA3	RPS6KA3	11124	-0.018	0.3	NO
169	DUSP3	DUSP3	DUSP3	11242	-0.019	0.29	NO
170	PPP2R1A	PPP2R1A	PPP2R1A	11343	-0.02	0.29	NO
171	CHUK	CHUK	CHUK	11383	-0.021	0.28	NO
172	PCBP2	PCBP2	PCBP2	11421	-0.021	0.28	NO
173	UBE2K	UBE2K	UBE2K	11438	-0.021	0.28	NO
174	IFIH1	IFIH1	IFIH1	11532	-0.022	0.28	NO
175	PANX1	PANX1	PANX1	11607	-0.023	0.28	NO
176	HMGB1	HMGB1	HMGB1	11618	-0.023	0.28	NO
177	CASP2	CASP2	CASP2	11703	-0.024	0.27	NO
178	MAP3K7	MAP3K7	MAP3K7	11753	-0.024	0.27	NO
179	CREB1	CREB1	CREB1	11758	-0.024	0.27	NO
180	DDX58	DDX58	DDX58	12178	-0.029	0.25	NO
181	MAPK10	MAPK10	MAPK10	12254	-0.03	0.24	NO
182	MAPKAPK2	MAPKAPK2	MAPKAPK2	12364	-0.032	0.24	NO
183	CREBBP	CREBBP	CREBBP	12366	-0.032	0.24	NO
184	MAP2K6	MAP2K6	MAP2K6	12493	-0.033	0.24	NO
185	TAB3	TAB3	TAB3	12598	-0.035	0.23	NO
186	MAP2K7	MAP2K7	MAP2K7	12660	-0.036	0.23	NO
187	ATF1	ATF1	ATF1	12757	-0.037	0.22	NO
188	DNM1	DNM1	DNM1	12956	-0.039	0.21	NO
189	ELK1	ELK1	ELK1	13018	-0.04	0.21	NO
190	TRIM25	TRIM25	TRIM25	13024	-0.04	0.21	NO
191	PELI3	PELI3	PELI3	13046	-0.04	0.21	NO
192	MAPK9	MAPK9	MAPK9	13400	-0.045	0.2	NO
193	PPP2R1B	PPP2R1B	PPP2R1B	13462	-0.046	0.19	NO
194	CD46	CD46	CD46	13496	-0.047	0.19	NO
195	MAVS	MAVS	MAVS	13638	-0.049	0.19	NO
196	PPP2R5D	PPP2R5D	PPP2R5D	13860	-0.052	0.18	NO
197	MAPK12	MAPK12	MAPK12	13997	-0.055	0.17	NO
198	TAX1BP1	TAX1BP1	TAX1BP1	14068	-0.056	0.17	NO
199	PELI2	PELI2	PELI2	14134	-0.057	0.17	NO
200	SIGIRR	SIGIRR	SIGIRR	14344	-0.061	0.16	NO
201	EP300	EP300	EP300	14576	-0.066	0.14	NO
202	SIKE1	SIKE1	SIKE1	14695	-0.069	0.14	NO
203	C8G	C8G	C8G	14778	-0.071	0.14	NO
204	MEF2A	MEF2A	MEF2A	14990	-0.076	0.13	NO
205	MASP2	MASP2	MASP2	15173	-0.08	0.12	NO
206	DNM2	DNM2	DNM2	15507	-0.09	0.11	NO
207	EEA1	EEA1	EEA1	15562	-0.092	0.11	NO
208	ATF2	ATF2	ATF2	15611	-0.093	0.11	NO
209	TIRAP	TIRAP	TIRAP	15916	-0.1	0.093	NO
210	MAPK8	MAPK8	MAPK8	16073	-0.11	0.088	NO
211	DUSP6	DUSP6	DUSP6	16342	-0.12	0.077	NO
212	C5	C5	C5	17368	-0.2	0.026	NO
213	CDK1	CDK1	CDK1	17655	-0.25	0.018	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	OSM	OSM	OSM	74	0.64	0.14	YES
2	IRF8	IRF8	IRF8	449	0.42	0.2	YES
3	CSF2RA	CSF2RA	CSF2RA	483	0.4	0.29	YES
4	CSF2RB	CSF2RB	CSF2RB	487	0.4	0.38	YES
5	CCL2	CCL2	CCL2	580	0.38	0.46	YES
6	INPP5D	INPP5D	INPP5D	921	0.3	0.5	YES
7	FOS	FOS	FOS	1040	0.27	0.56	YES
8	CISH	CISH	CISH	1203	0.25	0.6	YES
9	SYK	SYK	SYK	1397	0.22	0.64	YES
10	LYN	LYN	LYN	1867	0.18	0.65	YES
11	STAT5A	STAT5A	STAT5A	1907	0.18	0.69	YES
12	CSF2	CSF2	CSF2	2099	0.16	0.71	YES
13	GAB2	GAB2	GAB2	2419	0.14	0.72	YES
14	GRB2	GRB2	GRB2	4058	0.067	0.65	NO
15	STAT3	STAT3	STAT3	4893	0.048	0.61	NO
16	PRKACB	PRKACB	PRKACB	5003	0.046	0.62	NO
17	IKBKB	IKBKB	IKBKB	6018	0.031	0.57	NO
18	MAPK3	MAPK3	MAPK3	6174	0.029	0.56	NO
19	PIM1	PIM1	PIM1	6558	0.025	0.55	NO
20	RAF1	RAF1	RAF1	6729	0.023	0.54	NO
21	STAT5B	STAT5B	STAT5B	7271	0.018	0.52	NO
22	STAT1	STAT1	STAT1	7441	0.016	0.51	NO
23	MAP2K1	MAP2K1	MAP2K1	8849	0.0025	0.43	NO
24	PIK3R1	PIK3R1	PIK3R1	9374	-0.0023	0.4	NO
25	PRKACA	PRKACA	PRKACA	9680	-0.005	0.39	NO
26	YWHAZ	YWHAZ	YWHAZ	10256	-0.01	0.36	NO
27	MAPK1	MAPK1	MAPK1	10282	-0.01	0.36	NO
28	MAP2K2	MAP2K2	MAP2K2	10729	-0.015	0.34	NO
29	JAK2	JAK2	JAK2	11420	-0.021	0.3	NO
30	PTPN11	PTPN11	PTPN11	11699	-0.024	0.29	NO
31	HRAS	HRAS	HRAS	12133	-0.029	0.28	NO
32	NRAS	NRAS	NRAS	12310	-0.031	0.27	NO
33	KRAS	KRAS	KRAS	13155	-0.042	0.24	NO
34	SHC1	SHC1	SHC1	13338	-0.044	0.24	NO
35	PIK3CA	PIK3CA	PIK3CA	13417	-0.046	0.24	NO
36	SOS1	SOS1	SOS1	14418	-0.062	0.2	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	CD28	CD28	CD28	157	0.55	0.066	YES
2	HCK	HCK	HCK	268	0.48	0.13	YES
3	CD8B	CD8B	CD8B	361	0.44	0.18	YES
4	LCK	LCK	LCK	371	0.44	0.24	YES
5	CD247	CD247	CD247	385	0.44	0.3	YES
6	DOCK2	DOCK2	DOCK2	417	0.42	0.36	YES
7	CD4	CD4	CD4	652	0.36	0.39	YES
8	AP1S2	AP1S2	AP1S2	811	0.32	0.43	YES
9	ELMO1	ELMO1	ELMO1	1151	0.26	0.44	YES
10	PSMB9	PSMB9	PSMB9	1979	0.17	0.42	YES
11	APOBEC3G	APOBEC3G	APOBEC3G	2003	0.17	0.44	YES
12	RCC1	RCC1	RCC1	2485	0.13	0.43	YES
13	B2M	B2M	B2M	2648	0.12	0.44	YES
14	PSMB10	PSMB10	PSMB10	2729	0.12	0.45	YES
15	AP1B1	AP1B1	AP1B1	2808	0.12	0.46	YES
16	HLA-A	HLA-A	HLA-A	3667	0.08	0.43	NO
17	PSMB8	PSMB8	PSMB8	3949	0.07	0.42	NO
18	AP2S1	AP2S1	AP2S1	4389	0.059	0.4	NO
19	PSMB3	PSMB3	PSMB3	4651	0.053	0.4	NO
20	HMGA1	HMGA1	HMGA1	4970	0.047	0.38	NO
21	PSMD2	PSMD2	PSMD2	5110	0.045	0.38	NO
22	PSME2	PSME2	PSME2	5144	0.044	0.39	NO
23	PSMB6	PSMB6	PSMB6	5205	0.043	0.39	NO
24	PSMC1	PSMC1	PSMC1	5304	0.041	0.39	NO
25	NUP85	NUP85	NUP85	5321	0.041	0.4	NO
26	PSMB2	PSMB2	PSMB2	5334	0.041	0.4	NO
27	NUP37	NUP37	NUP37	5515	0.038	0.4	NO
28	PSMD13	PSMD13	PSMD13	5717	0.035	0.39	NO
29	RAC1	RAC1	RAC1	5724	0.035	0.39	NO
30	PSME4	PSME4	PSME4	5885	0.033	0.39	NO
31	PSMD7	PSMD7	PSMD7	5968	0.032	0.39	NO
32	NUP93	NUP93	NUP93	5992	0.031	0.39	NO
33	PSMA2	PSMA2	PSMA2	6105	0.03	0.39	NO
34	PSMC2	PSMC2	PSMC2	6209	0.029	0.39	NO
35	PSMB1	PSMB1	PSMB1	6314	0.028	0.38	NO
36	RBX1	RBX1	RBX1	6382	0.027	0.38	NO
37	PSMD6	PSMD6	PSMD6	6407	0.027	0.39	NO
38	ATP6V1H	ATP6V1H	ATP6V1H	6480	0.026	0.39	NO
39	UBA52	UBA52	UBA52	6549	0.025	0.39	NO
40	PSMC5	PSMC5	PSMC5	6570	0.025	0.39	NO
41	PSMD9	PSMD9	PSMD9	6688	0.024	0.38	NO
42	RANBP1	RANBP1	RANBP1	6693	0.024	0.39	NO
43	AAAS	AAAS	AAAS	6835	0.022	0.38	NO
44	PSME1	PSME1	PSME1	6847	0.022	0.39	NO
45	CDK9	CDK9	CDK9	6873	0.022	0.39	NO
46	PSMA5	PSMA5	PSMA5	6925	0.021	0.39	NO
47	TCEB2	TCEB2	TCEB2	6933	0.021	0.39	NO
48	PSMC3	PSMC3	PSMC3	7112	0.019	0.38	NO
49	AP2M1	AP2M1	AP2M1	7130	0.019	0.38	NO
50	AP2A2	AP2A2	AP2A2	7292	0.018	0.38	NO
51	RANGAP1	RANGAP1	RANGAP1	7348	0.017	0.38	NO
52	AP1S1	AP1S1	AP1S1	7356	0.017	0.38	NO
53	PSMD11	PSMD11	PSMD11	7408	0.016	0.38	NO
54	PSMD3	PSMD3	PSMD3	7542	0.015	0.37	NO
55	NUP62	NUP62	NUP62	7561	0.015	0.37	NO
56	PSMD4	PSMD4	PSMD4	7566	0.015	0.38	NO
57	PSMD1	PSMD1	PSMD1	7628	0.014	0.38	NO
58	AP2B1	AP2B1	AP2B1	7748	0.013	0.37	NO
59	RPS27A	RPS27A	RPS27A	7758	0.013	0.37	NO
60	PSMA7	PSMA7	PSMA7	7929	0.011	0.36	NO
61	PAK2	PAK2	PAK2	7956	0.011	0.36	NO
62	PSMB4	PSMB4	PSMB4	8010	0.011	0.36	NO
63	PSMA6	PSMA6	PSMA6	8149	0.0091	0.36	NO
64	PSMD14	PSMD14	PSMD14	8153	0.0091	0.36	NO
65	BANF1	BANF1	BANF1	8158	0.009	0.36	NO
66	PSMA3	PSMA3	PSMA3	8168	0.0088	0.36	NO
67	PSMA1	PSMA1	PSMA1	8235	0.0082	0.36	NO
68	RAN	RAN	RAN	8322	0.0074	0.35	NO
69	PSMC4	PSMC4	PSMC4	8529	0.0054	0.34	NO
70	NUP188	NUP188	NUP188	8746	0.0035	0.33	NO
71	PPIA	PPIA	PPIA	8752	0.0035	0.33	NO
72	KPNA1	KPNA1	KPNA1	8780	0.0032	0.33	NO
73	PACS1	PACS1	PACS1	8860	0.0024	0.32	NO
74	PSMB5	PSMB5	PSMB5	8995	0.0012	0.32	NO
75	NUP107	NUP107	NUP107	9120	0.00013	0.31	NO
76	NUP88	NUP88	NUP88	9362	-0.0021	0.3	NO
77	PSMB7	PSMB7	PSMB7	9405	-0.0025	0.3	NO
78	AP1G1	AP1G1	AP1G1	9416	-0.0027	0.29	NO
79	NUP214	NUP214	NUP214	9622	-0.0044	0.28	NO
80	PSMA4	PSMA4	PSMA4	9625	-0.0044	0.28	NO
81	AP2A1	AP2A1	AP2A1	9833	-0.0064	0.27	NO
82	NUP210	NUP210	NUP210	9888	-0.0068	0.27	NO
83	ARF1	ARF1	ARF1	9920	-0.0071	0.27	NO
84	PSMD8	PSMD8	PSMD8	10120	-0.0089	0.26	NO
85	SKP1	SKP1	SKP1	10171	-0.0094	0.26	NO
86	BTRC	BTRC	BTRC	10258	-0.01	0.26	NO
87	PSMD10	PSMD10	PSMD10	10355	-0.011	0.25	NO
88	PSMD12	PSMD12	PSMD12	10553	-0.013	0.24	NO
89	PSMC6	PSMC6	PSMC6	10581	-0.013	0.24	NO
90	NUPL1	NUPL1	NUPL1	10669	-0.014	0.24	NO
91	SLC25A5	SLC25A5	SLC25A5	10801	-0.015	0.24	NO
92	NUP54	NUP54	NUP54	10822	-0.016	0.24	NO
93	RAE1	RAE1	RAE1	10874	-0.016	0.24	NO
94	NUP50	NUP50	NUP50	11026	-0.017	0.23	NO
95	NUPL2	NUPL2	NUPL2	11087	-0.018	0.23	NO
96	PSMD5	PSMD5	PSMD5	11105	-0.018	0.23	NO
97	TCEB1	TCEB1	TCEB1	11130	-0.018	0.23	NO
98	NUP133	NUP133	NUP133	11172	-0.019	0.23	NO
99	RANBP2	RANBP2	RANBP2	11230	-0.019	0.23	NO
100	XPO1	XPO1	XPO1	11872	-0.026	0.2	NO
101	AP1M1	AP1M1	AP1M1	12213	-0.03	0.18	NO
102	NUP153	NUP153	NUP153	12319	-0.031	0.18	NO
103	PSMF1	PSMF1	PSMF1	12360	-0.032	0.18	NO
104	POM121	POM121	POM121	12385	-0.032	0.19	NO
105	KPNB1	KPNB1	KPNB1	12609	-0.035	0.18	NO
106	NUP43	NUP43	NUP43	12863	-0.038	0.17	NO
107	NUP205	NUP205	NUP205	12919	-0.039	0.17	NO
108	SLC25A6	SLC25A6	SLC25A6	13124	-0.041	0.17	NO
109	NPM1	NPM1	NPM1	13255	-0.043	0.16	NO
110	SEH1L	SEH1L	SEH1L	13260	-0.043	0.17	NO
111	SLC25A4	SLC25A4	SLC25A4	13283	-0.044	0.18	NO
112	CUL5	CUL5	CUL5	13335	-0.044	0.18	NO
113	AP1M2	AP1M2	AP1M2	13613	-0.049	0.17	NO
114	NUP35	NUP35	NUP35	14645	-0.068	0.12	NO
115	PSIP1	PSIP1	PSIP1	14834	-0.072	0.12	NO
116	FYN	FYN	FYN	15324	-0.084	0.1	NO
117	NUP155	NUP155	NUP155	15328	-0.084	0.12	NO
118	TPR	TPR	TPR	15918	-0.1	0.097	NO
119	CCNT1	CCNT1	CCNT1	16483	-0.13	0.084	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	IL1RN	IL1RN	IL1RN	133	0.56	0.014	YES
2	IL2RA	IL2RA	IL2RA	209	0.51	0.029	YES
3	NOD2	NOD2	NOD2	218	0.5	0.048	YES
4	VAV1	VAV1	VAV1	250	0.49	0.064	YES
5	HCK	HCK	HCK	268	0.48	0.082	YES
6	FCGR1A	FCGR1A	FCGR1A	339	0.45	0.095	YES
7	HGF	HGF	HGF	354	0.45	0.11	YES
8	LCK	LCK	LCK	371	0.44	0.13	YES
9	IL2RG	IL2RG	IL2RG	377	0.44	0.14	YES
10	HLA-DQA2	HLA-DQA2	HLA-DQA2	398	0.43	0.16	YES
11	GBP5	GBP5	GBP5	443	0.42	0.17	YES
12	IRF8	IRF8	IRF8	449	0.42	0.19	YES
13	HLA-G	HLA-G	HLA-G	455	0.41	0.2	YES
14	CSF2RA	CSF2RA	CSF2RA	483	0.4	0.22	YES
15	CSF2RB	CSF2RB	CSF2RB	487	0.4	0.23	YES
16	IRF4	IRF4	IRF4	489	0.4	0.25	YES
17	HLA-DQA1	HLA-DQA1	HLA-DQA1	497	0.4	0.26	YES
18	HLA-DRB5	HLA-DRB5	HLA-DRB5	534	0.39	0.27	YES
19	PTAFR	PTAFR	PTAFR	568	0.38	0.29	YES
20	FCGR1B	FCGR1B	FCGR1B	571	0.38	0.3	YES
21	IRAK3	IRAK3	IRAK3	574	0.38	0.32	YES
22	IL1B	IL1B	IL1B	671	0.36	0.32	YES
23	MX2	MX2	MX2	690	0.35	0.34	YES
24	CASP1	CASP1	CASP1	754	0.34	0.35	YES
25	IL7R	IL7R	IL7R	787	0.33	0.36	YES
26	IL2RB	IL2RB	IL2RB	792	0.33	0.37	YES
27	IL1A	IL1A	IL1A	793	0.33	0.38	YES
28	CIITA	CIITA	CIITA	806	0.32	0.39	YES
29	HLA-DRB1	HLA-DRB1	HLA-DRB1	889	0.3	0.4	YES
30	SOCS3	SOCS3	SOCS3	900	0.3	0.41	YES
31	HLA-DPB1	HLA-DPB1	HLA-DPB1	954	0.29	0.42	YES
32	OAS2	OAS2	OAS2	981	0.28	0.43	YES
33	CD44	CD44	CD44	1116	0.26	0.43	YES
34	HLA-DPA1	HLA-DPA1	HLA-DPA1	1171	0.25	0.44	YES
35	CISH	CISH	CISH	1203	0.25	0.44	YES
36	IL6	IL6	IL6	1257	0.24	0.45	YES
37	IL1R2	IL1R2	IL1R2	1337	0.23	0.45	YES
38	ICAM1	ICAM1	ICAM1	1351	0.23	0.46	YES
39	SYK	SYK	SYK	1397	0.22	0.47	YES
40	IL2	IL2	IL2	1410	0.22	0.48	YES
41	VCAM1	VCAM1	VCAM1	1631	0.2	0.47	YES
42	MT2A	MT2A	MT2A	1676	0.2	0.48	YES
43	IFI27	IFI27	IFI27	1700	0.19	0.48	YES
44	OASL	OASL	OASL	1717	0.19	0.49	YES
45	PIK3CD	PIK3CD	PIK3CD	1823	0.18	0.49	YES
46	LYN	LYN	LYN	1867	0.18	0.49	YES
47	STAT5A	STAT5A	STAT5A	1907	0.18	0.5	YES
48	IL1RAP	IL1RAP	IL1RAP	1942	0.17	0.5	YES
49	ISG20	ISG20	ISG20	1976	0.17	0.51	YES
50	MAP3K8	MAP3K8	MAP3K8	1978	0.17	0.51	YES
51	SOCS1	SOCS1	SOCS1	2012	0.17	0.52	YES
52	EGR1	EGR1	EGR1	2062	0.16	0.52	YES
53	HLA-F	HLA-F	HLA-F	2078	0.16	0.53	YES
54	CSF2	CSF2	CSF2	2099	0.16	0.53	YES
55	GAB2	GAB2	GAB2	2419	0.14	0.52	YES
56	BLNK	BLNK	BLNK	2522	0.13	0.52	YES
57	XAF1	XAF1	XAF1	2621	0.12	0.52	YES
58	IL5RA	IL5RA	IL5RA	2626	0.12	0.52	YES
59	IRF1	IRF1	IRF1	2628	0.12	0.53	YES
60	JAK3	JAK3	JAK3	2634	0.12	0.53	YES
61	IFI6	IFI6	IFI6	2635	0.12	0.54	YES
62	B2M	B2M	B2M	2648	0.12	0.54	YES
63	PTPN6	PTPN6	PTPN6	2652	0.12	0.54	YES
64	IL18	IL18	IL18	2681	0.12	0.55	YES
65	HLA-B	HLA-B	HLA-B	2725	0.12	0.55	YES
66	UBA7	UBA7	UBA7	2735	0.12	0.55	YES
67	ISG15	ISG15	ISG15	2748	0.12	0.56	YES
68	UBE2L6	UBE2L6	UBE2L6	2770	0.12	0.56	YES
69	PTK2B	PTK2B	PTK2B	2926	0.11	0.56	YES
70	GBP4	GBP4	GBP4	2967	0.11	0.56	YES
71	MX1	MX1	MX1	2973	0.11	0.56	YES
72	IFITM2	IFITM2	IFITM2	2979	0.11	0.56	YES
73	TEC	TEC	TEC	2991	0.11	0.57	YES
74	PELI1	PELI1	PELI1	3111	0.1	0.57	YES
75	IFNG	IFNG	IFNG	3130	0.1	0.57	YES
76	IRF6	IRF6	IRF6	3176	0.098	0.57	YES
77	MYD88	MYD88	MYD88	3280	0.095	0.57	YES
78	IFNAR2	IFNAR2	IFNAR2	3282	0.094	0.57	YES
79	IL3RA	IL3RA	IL3RA	3308	0.094	0.57	YES
80	IFNGR2	IFNGR2	IFNGR2	3336	0.093	0.57	YES
81	IFNGR1	IFNGR1	IFNGR1	3365	0.092	0.58	YES
82	HLA-C	HLA-C	HLA-C	3456	0.088	0.58	YES
83	RIPK2	RIPK2	RIPK2	3496	0.086	0.58	YES
84	NCAM1	NCAM1	NCAM1	3564	0.083	0.58	YES
85	PML	PML	PML	3594	0.082	0.58	YES
86	HLA-A	HLA-A	HLA-A	3667	0.08	0.58	YES
87	IFI35	IFI35	IFI35	3709	0.078	0.58	YES
88	IRF5	IRF5	IRF5	3717	0.078	0.58	YES
89	STAT2	STAT2	STAT2	3841	0.074	0.58	YES
90	IRAK2	IRAK2	IRAK2	3874	0.072	0.58	YES
91	IFITM3	IFITM3	IFITM3	3896	0.072	0.58	YES
92	OAS1	OAS1	OAS1	3934	0.07	0.58	YES
93	PSMB8	PSMB8	PSMB8	3949	0.07	0.58	YES
94	GRB2	GRB2	GRB2	4058	0.067	0.58	NO
95	IRF7	IRF7	IRF7	4069	0.067	0.58	NO
96	PRKCD	PRKCD	PRKCD	4123	0.066	0.58	NO
97	GBP1	GBP1	GBP1	4183	0.064	0.58	NO
98	HERC5	HERC5	HERC5	4290	0.061	0.57	NO
99	NOD1	NOD1	NOD1	4497	0.056	0.56	NO
100	PTPN2	PTPN2	PTPN2	4570	0.055	0.56	NO
101	PTPN1	PTPN1	PTPN1	4582	0.054	0.56	NO
102	IRAK4	IRAK4	IRAK4	4658	0.053	0.56	NO
103	NFKB2	NFKB2	NFKB2	4710	0.052	0.56	NO
104	IFIT2	IFIT2	IFIT2	4785	0.05	0.56	NO
105	STAT3	STAT3	STAT3	4893	0.048	0.55	NO
106	USP18	USP18	USP18	4940	0.048	0.55	NO
107	PRKACB	PRKACB	PRKACB	5003	0.046	0.55	NO
108	IFITM1	IFITM1	IFITM1	5259	0.042	0.54	NO
109	NUP85	NUP85	NUP85	5321	0.041	0.54	NO
110	NUP37	NUP37	NUP37	5515	0.038	0.53	NO
111	SOCS2	SOCS2	SOCS2	5548	0.038	0.53	NO
112	EIF4A3	EIF4A3	EIF4A3	5638	0.036	0.52	NO
113	RNASEL	RNASEL	RNASEL	5694	0.036	0.52	NO
114	GBP2	GBP2	GBP2	5698	0.036	0.52	NO
115	EIF4A1	EIF4A1	EIF4A1	5709	0.035	0.52	NO
116	IRF9	IRF9	IRF9	5740	0.035	0.52	NO
117	IRF3	IRF3	IRF3	5825	0.034	0.52	NO
118	IP6K2	IP6K2	IP6K2	5843	0.033	0.52	NO
119	OAS3	OAS3	OAS3	5970	0.032	0.52	NO
120	IKBKG	IKBKG	IKBKG	5982	0.032	0.52	NO
121	NUP93	NUP93	NUP93	5992	0.031	0.52	NO
122	IKBKB	IKBKB	IKBKB	6018	0.031	0.52	NO
123	IRF2	IRF2	IRF2	6081	0.03	0.51	NO
124	MAPK3	MAPK3	MAPK3	6174	0.029	0.51	NO
125	SQSTM1	SQSTM1	SQSTM1	6304	0.028	0.5	NO
126	RBX1	RBX1	RBX1	6382	0.027	0.5	NO
127	IL1R1	IL1R1	IL1R1	6438	0.026	0.5	NO
128	UBA52	UBA52	UBA52	6549	0.025	0.49	NO
129	RAF1	RAF1	RAF1	6729	0.023	0.48	NO
130	AAAS	AAAS	AAAS	6835	0.022	0.48	NO
131	EIF4G1	EIF4G1	EIF4G1	6884	0.022	0.48	NO
132	UBE2E1	UBE2E1	UBE2E1	6896	0.022	0.48	NO
133	IFNAR1	IFNAR1	IFNAR1	7076	0.02	0.47	NO
134	IRS2	IRS2	IRS2	7100	0.019	0.47	NO
135	IFNA1	IFNA1	IFNA1	7109	0.019	0.47	NO
136	RAPGEF1	RAPGEF1	RAPGEF1	7126	0.019	0.47	NO
137	TYK2	TYK2	TYK2	7206	0.018	0.46	NO
138	STAT5B	STAT5B	STAT5B	7271	0.018	0.46	NO
139	MAP3K3	MAP3K3	MAP3K3	7309	0.018	0.46	NO
140	TNIP2	TNIP2	TNIP2	7317	0.017	0.46	NO
141	EIF4E3	EIF4E3	EIF4E3	7354	0.017	0.46	NO
142	STAT1	STAT1	STAT1	7441	0.016	0.45	NO
143	IRAK1	IRAK1	IRAK1	7543	0.015	0.45	NO
144	NUP62	NUP62	NUP62	7561	0.015	0.45	NO
145	TAB1	TAB1	TAB1	7601	0.015	0.45	NO
146	RPS27A	RPS27A	RPS27A	7758	0.013	0.44	NO
147	KPNA4	KPNA4	KPNA4	7792	0.013	0.44	NO
148	IL6R	IL6R	IL6R	7804	0.013	0.44	NO
149	GBP6	GBP6	GBP6	7845	0.012	0.43	NO
150	IL7	IL7	IL7	7894	0.012	0.43	NO
151	ADAM17	ADAM17	ADAM17	7976	0.011	0.43	NO
152	JAK1	JAK1	JAK1	8104	0.0096	0.42	NO
153	SP100	SP100	SP100	8108	0.0095	0.42	NO
154	RELA	RELA	RELA	8154	0.0091	0.42	NO
155	PIN1	PIN1	PIN1	8344	0.0073	0.41	NO
156	TAB2	TAB2	TAB2	8549	0.0052	0.4	NO
157	UBE2N	UBE2N	UBE2N	8628	0.0045	0.39	NO
158	PIK3CB	PIK3CB	PIK3CB	8641	0.0044	0.39	NO
159	NUP188	NUP188	NUP188	8746	0.0035	0.39	NO
160	SH2B1	SH2B1	SH2B1	8764	0.0034	0.39	NO
161	KPNA1	KPNA1	KPNA1	8780	0.0032	0.38	NO
162	MAP2K1	MAP2K1	MAP2K1	8849	0.0025	0.38	NO
163	MAP2K4	MAP2K4	MAP2K4	8930	0.0018	0.38	NO
164	EIF4E2	EIF4E2	EIF4E2	9071	0.00056	0.37	NO
165	NUP107	NUP107	NUP107	9120	0.00013	0.37	NO
166	CRKL	CRKL	CRKL	9158	-0.00022	0.36	NO
167	IFIT3	IFIT3	IFIT3	9195	-0.00054	0.36	NO
168	NUP88	NUP88	NUP88	9362	-0.0021	0.35	NO
169	PIK3R1	PIK3R1	PIK3R1	9374	-0.0023	0.35	NO
170	KPNA3	KPNA3	KPNA3	9378	-0.0023	0.35	NO
171	EIF4A2	EIF4A2	EIF4A2	9582	-0.0041	0.34	NO
172	NUP214	NUP214	NUP214	9622	-0.0044	0.34	NO
173	NUP210	NUP210	NUP210	9888	-0.0068	0.32	NO
174	YWHAB	YWHAB	YWHAB	9907	-0.007	0.32	NO
175	SKP1	SKP1	SKP1	10171	-0.0094	0.31	NO
176	YWHAZ	YWHAZ	YWHAZ	10256	-0.01	0.3	NO
177	BTRC	BTRC	BTRC	10258	-0.01	0.3	NO
178	MAPK1	MAPK1	MAPK1	10282	-0.01	0.3	NO
179	INPPL1	INPPL1	INPPL1	10337	-0.011	0.3	NO
180	CAMK2D	CAMK2D	CAMK2D	10389	-0.012	0.3	NO
181	EIF4G2	EIF4G2	EIF4G2	10412	-0.012	0.3	NO
182	SUMO1	SUMO1	SUMO1	10521	-0.013	0.29	NO
183	NUPL1	NUPL1	NUPL1	10669	-0.014	0.28	NO
184	MAP2K2	MAP2K2	MAP2K2	10729	-0.015	0.28	NO
185	PIAS1	PIAS1	PIAS1	10795	-0.015	0.28	NO
186	NUP54	NUP54	NUP54	10822	-0.016	0.28	NO
187	ADAR	ADAR	ADAR	10869	-0.016	0.28	NO
188	RAE1	RAE1	RAE1	10874	-0.016	0.28	NO
189	EIF4E	EIF4E	EIF4E	10907	-0.016	0.28	NO
190	TRAF6	TRAF6	TRAF6	10909	-0.016	0.28	NO
191	NUP50	NUP50	NUP50	11026	-0.017	0.27	NO
192	NUPL2	NUPL2	NUPL2	11087	-0.018	0.27	NO
193	NUP133	NUP133	NUP133	11172	-0.019	0.26	NO
194	RANBP2	RANBP2	RANBP2	11230	-0.019	0.26	NO
195	CHUK	CHUK	CHUK	11383	-0.021	0.25	NO
196	KPNA2	KPNA2	KPNA2	11405	-0.021	0.25	NO
197	JAK2	JAK2	JAK2	11420	-0.021	0.25	NO
198	CUL1	CUL1	CUL1	11564	-0.022	0.25	NO
199	MAP3K7	MAP3K7	MAP3K7	11753	-0.024	0.24	NO
200	TOLLIP	TOLLIP	TOLLIP	11811	-0.025	0.23	NO
201	CBL	CBL	CBL	11882	-0.026	0.23	NO
202	PPM1B	PPM1B	PPM1B	12126	-0.029	0.22	NO
203	HRAS	HRAS	HRAS	12133	-0.029	0.22	NO
204	DDX58	DDX58	DDX58	12178	-0.029	0.22	NO
205	PLCG1	PLCG1	PLCG1	12183	-0.029	0.22	NO
206	NRAS	NRAS	NRAS	12310	-0.031	0.21	NO
207	PIK3R2	PIK3R2	PIK3R2	12317	-0.031	0.21	NO
208	NUP153	NUP153	NUP153	12319	-0.031	0.22	NO
209	ARIH1	ARIH1	ARIH1	12337	-0.031	0.22	NO
210	POM121	POM121	POM121	12385	-0.032	0.21	NO
211	IFIT1	IFIT1	IFIT1	12445	-0.033	0.21	NO
212	GHR	GHR	GHR	12488	-0.033	0.21	NO
213	MAP2K6	MAP2K6	MAP2K6	12493	-0.033	0.21	NO
214	CRK	CRK	CRK	12573	-0.034	0.21	NO
215	TAB3	TAB3	TAB3	12598	-0.035	0.21	NO
216	KPNB1	KPNB1	KPNB1	12609	-0.035	0.21	NO
217	NUP43	NUP43	NUP43	12863	-0.038	0.2	NO
218	NUP205	NUP205	NUP205	12919	-0.039	0.19	NO
219	TRIM25	TRIM25	TRIM25	13024	-0.04	0.19	NO
220	PELI3	PELI3	PELI3	13046	-0.04	0.19	NO
221	KRAS	KRAS	KRAS	13155	-0.042	0.19	NO
222	SEH1L	SEH1L	SEH1L	13260	-0.043	0.18	NO
223	SHC1	SHC1	SHC1	13338	-0.044	0.18	NO
224	PIK3CA	PIK3CA	PIK3CA	13417	-0.046	0.18	NO
225	EIF4G3	EIF4G3	EIF4G3	13617	-0.049	0.17	NO
226	FLNB	FLNB	FLNB	13931	-0.053	0.15	NO
227	GBP7	GBP7	GBP7	14114	-0.057	0.14	NO
228	PELI2	PELI2	PELI2	14134	-0.057	0.14	NO
229	SOS1	SOS1	SOS1	14418	-0.062	0.13	NO
230	CAMK2A	CAMK2A	CAMK2A	14421	-0.062	0.13	NO
231	PIK3R3	PIK3R3	PIK3R3	14526	-0.065	0.13	NO
232	NUP35	NUP35	NUP35	14645	-0.068	0.13	NO
233	YES1	YES1	YES1	14882	-0.073	0.12	NO
234	EIF2AK2	EIF2AK2	EIF2AK2	15051	-0.077	0.11	NO
235	IRS1	IRS1	IRS1	15165	-0.08	0.1	NO
236	FYN	FYN	FYN	15324	-0.084	0.099	NO
237	NUP155	NUP155	NUP155	15328	-0.084	0.1	NO
238	PRLR	PRLR	PRLR	15423	-0.088	0.1	NO
239	TPR	TPR	TPR	15918	-0.1	0.077	NO
240	NEDD4	NEDD4	NEDD4	16142	-0.11	0.068	NO
241	IL6ST	IL6ST	IL6ST	16865	-0.16	0.034	NO
242	KPNA5	KPNA5	KPNA5	17312	-0.2	0.016	NO
243	CDK1	CDK1	CDK1	17655	-0.25	0.0064	NO
244	CAMK2B	CAMK2B	CAMK2B	17848	-0.31	0.0075	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	MEFV	MEFV	MEFV	43	0.69	0.11	YES
2	NLRC4	NLRC4	NLRC4	67	0.65	0.21	YES
3	NOD2	NOD2	NOD2	218	0.5	0.28	YES
4	NLRP3	NLRP3	NLRP3	273	0.48	0.36	YES
5	PSTPIP1	PSTPIP1	PSTPIP1	358	0.44	0.43	YES
6	CARD9	CARD9	CARD9	689	0.35	0.46	YES
7	CASP1	CASP1	CASP1	754	0.34	0.52	YES
8	P2RX7	P2RX7	P2RX7	802	0.32	0.57	YES
9	AIM2	AIM2	AIM2	1053	0.27	0.6	YES
10	BIRC3	BIRC3	BIRC3	1133	0.26	0.63	YES
11	NLRP1	NLRP1	NLRP1	1173	0.25	0.67	YES
12	PYCARD	PYCARD	PYCARD	1248	0.24	0.71	YES
13	TNFAIP3	TNFAIP3	TNFAIP3	1720	0.19	0.71	YES
14	MAPK11	MAPK11	MAPK11	2307	0.14	0.7	YES
15	MAPK13	MAPK13	MAPK13	2430	0.14	0.72	YES
16	CASP4	CASP4	CASP4	2592	0.13	0.73	YES
17	TXNIP	TXNIP	TXNIP	3404	0.09	0.7	NO
18	RIPK2	RIPK2	RIPK2	3496	0.086	0.71	NO
19	IRAK2	IRAK2	IRAK2	3874	0.072	0.7	NO
20	NOD1	NOD1	NOD1	4497	0.056	0.67	NO
21	CYLD	CYLD	CYLD	4560	0.055	0.68	NO
22	IKBKG	IKBKG	IKBKG	5982	0.032	0.6	NO
23	IKBKB	IKBKB	IKBKB	6018	0.031	0.6	NO
24	BCL2L1	BCL2L1	BCL2L1	6177	0.029	0.6	NO
25	MAPK14	MAPK14	MAPK14	7042	0.02	0.56	NO
26	IRAK1	IRAK1	IRAK1	7543	0.015	0.53	NO
27	TAB1	TAB1	TAB1	7601	0.015	0.53	NO
28	CASP9	CASP9	CASP9	7846	0.012	0.52	NO
29	CASP8	CASP8	CASP8	8414	0.0066	0.49	NO
30	TAB2	TAB2	TAB2	8549	0.0052	0.48	NO
31	UBE2N	UBE2N	UBE2N	8628	0.0045	0.48	NO
32	BCL2	BCL2	BCL2	8744	0.0036	0.47	NO
33	TXN	TXN	TXN	9340	-0.0019	0.44	NO
34	APP	APP	APP	10072	-0.0085	0.4	NO
35	BIRC2	BIRC2	BIRC2	10138	-0.0091	0.4	NO
36	HSP90AB1	HSP90AB1	HSP90AB1	10773	-0.015	0.36	NO
37	TRAF6	TRAF6	TRAF6	10909	-0.016	0.36	NO
38	CHUK	CHUK	CHUK	11383	-0.021	0.34	NO
39	PANX1	PANX1	PANX1	11607	-0.023	0.33	NO
40	CASP2	CASP2	CASP2	11703	-0.024	0.33	NO
41	MAP3K7	MAP3K7	MAP3K7	11753	-0.024	0.33	NO
42	MAP2K6	MAP2K6	MAP2K6	12493	-0.033	0.29	NO
43	TAB3	TAB3	TAB3	12598	-0.035	0.29	NO
44	MAPK12	MAPK12	MAPK12	13997	-0.055	0.22	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	CD28	CD28	CD28	157	0.55	0.044	YES
2	HCK	HCK	HCK	268	0.48	0.085	YES
3	CCR5	CCR5	CCR5	355	0.45	0.12	YES
4	CD8B	CD8B	CD8B	361	0.44	0.17	YES
5	LCK	LCK	LCK	371	0.44	0.21	YES
6	CD247	CD247	CD247	385	0.44	0.25	YES
7	DOCK2	DOCK2	DOCK2	417	0.42	0.29	YES
8	CXCR4	CXCR4	CXCR4	578	0.38	0.32	YES
9	CD4	CD4	CD4	652	0.36	0.35	YES
10	AP1S2	AP1S2	AP1S2	811	0.32	0.37	YES
11	ELMO1	ELMO1	ELMO1	1151	0.26	0.37	YES
12	PSMB9	PSMB9	PSMB9	1979	0.17	0.34	NO
13	APOBEC3G	APOBEC3G	APOBEC3G	2003	0.17	0.36	NO
14	RCC1	RCC1	RCC1	2485	0.13	0.34	NO
15	B2M	B2M	B2M	2648	0.12	0.35	NO
16	PSMB10	PSMB10	PSMB10	2729	0.12	0.36	NO
17	AP1B1	AP1B1	AP1B1	2808	0.12	0.36	NO
18	GTF2H2B	GTF2H2B	GTF2H2B	2990	0.11	0.36	NO
19	GTF2E1	GTF2E1	GTF2E1	3649	0.08	0.33	NO
20	VPS37B	VPS37B	VPS37B	3652	0.08	0.34	NO
21	HLA-A	HLA-A	HLA-A	3667	0.08	0.35	NO
22	PSMB8	PSMB8	PSMB8	3949	0.07	0.34	NO
23	ELL	ELL	ELL	4350	0.06	0.32	NO
24	TAF13	TAF13	TAF13	4361	0.059	0.33	NO
25	AP2S1	AP2S1	AP2S1	4389	0.059	0.33	NO
26	PSMB3	PSMB3	PSMB3	4651	0.053	0.32	NO
27	POLR2L	POLR2L	POLR2L	4813	0.05	0.32	NO
28	HMGA1	HMGA1	HMGA1	4970	0.047	0.31	NO
29	PSMD2	PSMD2	PSMD2	5110	0.045	0.31	NO
30	PSME2	PSME2	PSME2	5144	0.044	0.31	NO
31	PSMB6	PSMB6	PSMB6	5205	0.043	0.31	NO
32	PSMC1	PSMC1	PSMC1	5304	0.041	0.31	NO
33	NUP85	NUP85	NUP85	5321	0.041	0.31	NO
34	PSMB2	PSMB2	PSMB2	5334	0.041	0.32	NO
35	TAF10	TAF10	TAF10	5366	0.04	0.32	NO
36	XRCC6	XRCC6	XRCC6	5411	0.04	0.32	NO
37	NUP37	NUP37	NUP37	5515	0.038	0.32	NO
38	PSMD13	PSMD13	PSMD13	5717	0.035	0.31	NO
39	RAC1	RAC1	RAC1	5724	0.035	0.31	NO
40	CTDP1	CTDP1	CTDP1	5739	0.035	0.32	NO
41	POLR2H	POLR2H	POLR2H	5875	0.033	0.31	NO
42	PSME4	PSME4	PSME4	5885	0.033	0.31	NO
43	VPS37D	VPS37D	VPS37D	5940	0.032	0.32	NO
44	PSMD7	PSMD7	PSMD7	5968	0.032	0.32	NO
45	NUP93	NUP93	NUP93	5992	0.031	0.32	NO
46	PSMA2	PSMA2	PSMA2	6105	0.03	0.31	NO
47	XRCC4	XRCC4	XRCC4	6134	0.03	0.32	NO
48	PSMC2	PSMC2	PSMC2	6209	0.029	0.31	NO
49	TCEB3	TCEB3	TCEB3	6291	0.028	0.31	NO
50	PSMB1	PSMB1	PSMB1	6314	0.028	0.31	NO
51	RBX1	RBX1	RBX1	6382	0.027	0.31	NO
52	PSMD6	PSMD6	PSMD6	6407	0.027	0.31	NO
53	GTF2F2	GTF2F2	GTF2F2	6449	0.026	0.31	NO
54	ATP6V1H	ATP6V1H	ATP6V1H	6480	0.026	0.32	NO
55	UBA52	UBA52	UBA52	6549	0.025	0.31	NO
56	PSMC5	PSMC5	PSMC5	6570	0.025	0.32	NO
57	GTF2B	GTF2B	GTF2B	6642	0.024	0.31	NO
58	PSMD9	PSMD9	PSMD9	6688	0.024	0.31	NO
59	RANBP1	RANBP1	RANBP1	6693	0.024	0.32	NO
60	AAAS	AAAS	AAAS	6835	0.022	0.31	NO
61	PSME1	PSME1	PSME1	6847	0.022	0.31	NO
62	CDK9	CDK9	CDK9	6873	0.022	0.31	NO
63	PSMA5	PSMA5	PSMA5	6925	0.021	0.31	NO
64	GTF2E2	GTF2E2	GTF2E2	6928	0.021	0.31	NO
65	TCEB2	TCEB2	TCEB2	6933	0.021	0.32	NO
66	VPS37C	VPS37C	VPS37C	6977	0.021	0.31	NO
67	PSMC3	PSMC3	PSMC3	7112	0.019	0.31	NO
68	AP2M1	AP2M1	AP2M1	7130	0.019	0.31	NO
69	GTF2H4	GTF2H4	GTF2H4	7195	0.019	0.31	NO
70	AP2A2	AP2A2	AP2A2	7292	0.018	0.3	NO
71	POLR2F	POLR2F	POLR2F	7318	0.017	0.3	NO
72	RANGAP1	RANGAP1	RANGAP1	7348	0.017	0.3	NO
73	AP1S1	AP1S1	AP1S1	7356	0.017	0.31	NO
74	PSMD11	PSMD11	PSMD11	7408	0.016	0.3	NO
75	NMT1	NMT1	NMT1	7505	0.016	0.3	NO
76	PSMD3	PSMD3	PSMD3	7542	0.015	0.3	NO
77	NUP62	NUP62	NUP62	7561	0.015	0.3	NO
78	PSMD4	PSMD4	PSMD4	7566	0.015	0.3	NO
79	PSMD1	PSMD1	PSMD1	7628	0.014	0.3	NO
80	AP2B1	AP2B1	AP2B1	7748	0.013	0.29	NO
81	TAF12	TAF12	TAF12	7755	0.013	0.3	NO
82	RPS27A	RPS27A	RPS27A	7758	0.013	0.3	NO
83	PSMA7	PSMA7	PSMA7	7929	0.011	0.29	NO
84	PAK2	PAK2	PAK2	7956	0.011	0.29	NO
85	PSMB4	PSMB4	PSMB4	8010	0.011	0.28	NO
86	PSMA6	PSMA6	PSMA6	8149	0.0091	0.28	NO
87	PSMD14	PSMD14	PSMD14	8153	0.0091	0.28	NO
88	BANF1	BANF1	BANF1	8158	0.009	0.28	NO
89	PSMA3	PSMA3	PSMA3	8168	0.0088	0.28	NO
90	RNGTT	RNGTT	RNGTT	8172	0.0088	0.28	NO
91	NCBP2	NCBP2	NCBP2	8187	0.0087	0.28	NO
92	PSMA1	PSMA1	PSMA1	8235	0.0082	0.28	NO
93	POLR2G	POLR2G	POLR2G	8301	0.0076	0.28	NO
94	RAN	RAN	RAN	8322	0.0074	0.28	NO
95	TAF11	TAF11	TAF11	8380	0.007	0.27	NO
96	COBRA1	COBRA1	COBRA1	8508	0.0056	0.27	NO
97	PSMC4	PSMC4	PSMC4	8529	0.0054	0.27	NO
98	SUPT4H1	SUPT4H1	SUPT4H1	8741	0.0036	0.25	NO
99	NUP188	NUP188	NUP188	8746	0.0035	0.26	NO
100	PPIA	PPIA	PPIA	8752	0.0035	0.26	NO
101	KPNA1	KPNA1	KPNA1	8780	0.0032	0.25	NO
102	POLR2C	POLR2C	POLR2C	8853	0.0025	0.25	NO
103	PACS1	PACS1	PACS1	8860	0.0024	0.25	NO
104	PSMB5	PSMB5	PSMB5	8995	0.0012	0.24	NO
105	NUP107	NUP107	NUP107	9120	0.00013	0.24	NO
106	POLR2B	POLR2B	POLR2B	9129	-5e-05	0.24	NO
107	TSG101	TSG101	TSG101	9133	-0.000058	0.24	NO
108	RDBP	RDBP	RDBP	9172	-0.00036	0.23	NO
109	VPS28	VPS28	VPS28	9263	-0.0011	0.23	NO
110	NUP88	NUP88	NUP88	9362	-0.0021	0.22	NO
111	PSMB7	PSMB7	PSMB7	9405	-0.0025	0.22	NO
112	AP1G1	AP1G1	AP1G1	9416	-0.0027	0.22	NO
113	XRCC5	XRCC5	XRCC5	9533	-0.0037	0.21	NO
114	TAF6	TAF6	TAF6	9545	-0.0038	0.21	NO
115	TBP	TBP	TBP	9560	-0.004	0.21	NO
116	POLR2J	POLR2J	POLR2J	9566	-0.004	0.21	NO
117	NUP214	NUP214	NUP214	9622	-0.0044	0.21	NO
118	PSMA4	PSMA4	PSMA4	9625	-0.0044	0.21	NO
119	ERCC2	ERCC2	ERCC2	9675	-0.005	0.21	NO
120	GTF2A2	GTF2A2	GTF2A2	9695	-0.0051	0.21	NO
121	AP2A1	AP2A1	AP2A1	9833	-0.0064	0.2	NO
122	POLR2E	POLR2E	POLR2E	9881	-0.0068	0.2	NO
123	NUP210	NUP210	NUP210	9888	-0.0068	0.2	NO
124	SSRP1	SSRP1	SSRP1	9919	-0.0071	0.2	NO
125	ARF1	ARF1	ARF1	9920	-0.0071	0.2	NO
126	WHSC2	WHSC2	WHSC2	10100	-0.0088	0.19	NO
127	PSMD8	PSMD8	PSMD8	10120	-0.0089	0.19	NO
128	SKP1	SKP1	SKP1	10171	-0.0094	0.19	NO
129	POLR2A	POLR2A	POLR2A	10176	-0.0095	0.19	NO
130	POLR2D	POLR2D	POLR2D	10216	-0.0098	0.19	NO
131	BTRC	BTRC	BTRC	10258	-0.01	0.19	NO
132	PSMD10	PSMD10	PSMD10	10355	-0.011	0.18	NO
133	NCBP1	NCBP1	NCBP1	10523	-0.013	0.17	NO
134	PSMD12	PSMD12	PSMD12	10553	-0.013	0.17	NO
135	PSMC6	PSMC6	PSMC6	10581	-0.013	0.17	NO
136	NUPL1	NUPL1	NUPL1	10669	-0.014	0.17	NO
137	SLC25A5	SLC25A5	SLC25A5	10801	-0.015	0.16	NO
138	NUP54	NUP54	NUP54	10822	-0.016	0.16	NO
139	RAE1	RAE1	RAE1	10874	-0.016	0.16	NO
140	ERCC3	ERCC3	ERCC3	10937	-0.016	0.16	NO
141	RNMT	RNMT	RNMT	10979	-0.017	0.16	NO
142	GTF2F1	GTF2F1	GTF2F1	10984	-0.017	0.16	NO
143	POLR2I	POLR2I	POLR2I	11010	-0.017	0.16	NO
144	NUP50	NUP50	NUP50	11026	-0.017	0.16	NO
145	NUPL2	NUPL2	NUPL2	11087	-0.018	0.16	NO
146	PSMD5	PSMD5	PSMD5	11105	-0.018	0.16	NO
147	TCEB1	TCEB1	TCEB1	11130	-0.018	0.16	NO
148	SUPT5H	SUPT5H	SUPT5H	11139	-0.018	0.16	NO
149	CCNH	CCNH	CCNH	11155	-0.019	0.16	NO
150	NUP133	NUP133	NUP133	11172	-0.019	0.16	NO
151	RANBP2	RANBP2	RANBP2	11230	-0.019	0.16	NO
152	GTF2H1	GTF2H1	GTF2H1	11251	-0.02	0.16	NO
153	NMT2	NMT2	NMT2	11444	-0.021	0.16	NO
154	XPO1	XPO1	XPO1	11872	-0.026	0.13	NO
155	TH1L	TH1L	TH1L	12077	-0.028	0.12	NO
156	POLR2K	POLR2K	POLR2K	12116	-0.029	0.13	NO
157	AP1M1	AP1M1	AP1M1	12213	-0.03	0.12	NO
158	NUP153	NUP153	NUP153	12319	-0.031	0.12	NO
159	PSMF1	PSMF1	PSMF1	12360	-0.032	0.12	NO
160	POM121	POM121	POM121	12385	-0.032	0.12	NO
161	KPNB1	KPNB1	KPNB1	12609	-0.035	0.11	NO
162	TAF5	TAF5	TAF5	12665	-0.036	0.11	NO
163	SUPT16H	SUPT16H	SUPT16H	12818	-0.037	0.11	NO
164	NUP43	NUP43	NUP43	12863	-0.038	0.11	NO
165	FEN1	FEN1	FEN1	12914	-0.038	0.11	NO
166	NUP205	NUP205	NUP205	12919	-0.039	0.12	NO
167	GTF2H3	GTF2H3	GTF2H3	12962	-0.039	0.12	NO
168	LIG1	LIG1	LIG1	13048	-0.04	0.12	NO
169	VPS37A	VPS37A	VPS37A	13074	-0.041	0.12	NO
170	SLC25A6	SLC25A6	SLC25A6	13124	-0.041	0.12	NO
171	NPM1	NPM1	NPM1	13255	-0.043	0.12	NO
172	SEH1L	SEH1L	SEH1L	13260	-0.043	0.12	NO
173	TAF9	TAF9	TAF9	13276	-0.044	0.12	NO
174	SLC25A4	SLC25A4	SLC25A4	13283	-0.044	0.13	NO
175	CUL5	CUL5	CUL5	13335	-0.044	0.13	NO
176	AP1M2	AP1M2	AP1M2	13613	-0.049	0.12	NO
177	LIG4	LIG4	LIG4	13849	-0.052	0.11	NO
178	CDK7	CDK7	CDK7	14055	-0.056	0.1	NO
179	GTF2H2	GTF2H2	GTF2H2	14387	-0.062	0.091	NO
180	CCNT2	CCNT2	CCNT2	14590	-0.066	0.086	NO
181	TAF1	TAF1	TAF1	14636	-0.067	0.09	NO
182	NUP35	NUP35	NUP35	14645	-0.068	0.096	NO
183	PSIP1	PSIP1	PSIP1	14834	-0.072	0.092	NO
184	MNAT1	MNAT1	MNAT1	14865	-0.072	0.098	NO
185	TCEA1	TCEA1	TCEA1	15063	-0.077	0.094	NO
186	TAF4B	TAF4B	TAF4B	15181	-0.08	0.095	NO
187	FYN	FYN	FYN	15324	-0.084	0.096	NO
188	NUP155	NUP155	NUP155	15328	-0.084	0.1	NO
189	TPR	TPR	TPR	15918	-0.1	0.081	NO
190	TAF4	TAF4	TAF4	16179	-0.12	0.077	NO
191	GTF2A1	GTF2A1	GTF2A1	16182	-0.12	0.088	NO
192	CCNT1	CCNT1	CCNT1	16483	-0.13	0.084	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	IL1RN	IL1RN	IL1RN	133	0.56	0.16	YES
2	IRAK3	IRAK3	IRAK3	574	0.38	0.25	YES
3	IL1B	IL1B	IL1B	671	0.36	0.35	YES
4	CASP1	CASP1	CASP1	754	0.34	0.45	YES
5	IL1A	IL1A	IL1A	793	0.33	0.55	YES
6	IL1R2	IL1R2	IL1R2	1337	0.23	0.58	YES
7	TICAM2	TICAM2	TICAM2	1750	0.19	0.62	YES
8	IL1RAP	IL1RAP	IL1RAP	1942	0.17	0.66	YES
9	JUN	JUN	JUN	3209	0.097	0.62	NO
10	MYD88	MYD88	MYD88	3280	0.095	0.64	NO
11	IRAK4	IRAK4	IRAK4	4658	0.053	0.58	NO
12	IKBKG	IKBKG	IKBKG	5982	0.032	0.52	NO
13	IKBKB	IKBKB	IKBKB	6018	0.031	0.52	NO
14	NFKB1	NFKB1	NFKB1	6143	0.03	0.53	NO
15	SQSTM1	SQSTM1	SQSTM1	6304	0.028	0.53	NO
16	IL1R1	IL1R1	IL1R1	6438	0.026	0.53	NO
17	MAP3K3	MAP3K3	MAP3K3	7309	0.018	0.48	NO
18	IRAK1	IRAK1	IRAK1	7543	0.015	0.48	NO
19	TAB1	TAB1	TAB1	7601	0.015	0.48	NO
20	RELA	RELA	RELA	8154	0.0091	0.45	NO
21	TAB2	TAB2	TAB2	8549	0.0052	0.43	NO
22	ERC1	ERC1	ERC1	8561	0.0051	0.43	NO
23	UBE2N	UBE2N	UBE2N	8628	0.0045	0.43	NO
24	PRKCI	PRKCI	PRKCI	8910	0.002	0.41	NO
25	PIK3R1	PIK3R1	PIK3R1	9374	-0.0023	0.39	NO
26	PRKCZ	PRKCZ	PRKCZ	10899	-0.016	0.31	NO
27	TRAF6	TRAF6	TRAF6	10909	-0.016	0.31	NO
28	UBE2V1	UBE2V1	UBE2V1	10972	-0.017	0.31	NO
29	CHUK	CHUK	CHUK	11383	-0.021	0.3	NO
30	MAP3K7	MAP3K7	MAP3K7	11753	-0.024	0.28	NO
31	TOLLIP	TOLLIP	TOLLIP	11811	-0.025	0.29	NO
32	MAP2K6	MAP2K6	MAP2K6	12493	-0.033	0.26	NO
33	PIK3CA	PIK3CA	PIK3CA	13417	-0.046	0.22	NO
34	MAPK8	MAPK8	MAPK8	16073	-0.11	0.11	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	FAIM2	FAIM2	FAIM2	210	0.51	0.14	YES
2	BTK	BTK	BTK	245	0.49	0.29	YES
3	FASLG	FASLG	FASLG	699	0.35	0.37	YES
4	BIRC3	BIRC3	BIRC3	1133	0.26	0.42	YES
5	SYK	SYK	SYK	1397	0.22	0.48	YES
6	PIK3CD	PIK3CD	PIK3CD	1823	0.18	0.51	YES
7	BID	BID	BID	2079	0.16	0.54	YES
8	MAPK11	MAPK11	MAPK11	2307	0.14	0.57	YES
9	SMPD1	SMPD1	SMPD1	3897	0.072	0.5	NO
10	CASP3	CASP3	CASP3	4301	0.061	0.5	NO
11	FAS	FAS	FAS	4773	0.05	0.49	NO
12	CFLAR	CFLAR	CFLAR	5529	0.038	0.46	NO
13	CASP10	CASP10	CASP10	5725	0.035	0.46	NO
14	IKBKG	IKBKG	IKBKG	5982	0.032	0.46	NO
15	IKBKB	IKBKB	IKBKB	6018	0.031	0.46	NO
16	FADD	FADD	FADD	6484	0.026	0.44	NO
17	MAPK14	MAPK14	MAPK14	7042	0.02	0.42	NO
18	EZR	EZR	EZR	7426	0.016	0.4	NO
19	RIPK1	RIPK1	RIPK1	7600	0.015	0.4	NO
20	AKT1	AKT1	AKT1	8062	0.01	0.38	NO
21	CASP8	CASP8	CASP8	8414	0.0066	0.36	NO
22	PIK3CB	PIK3CB	PIK3CB	8641	0.0044	0.35	NO
23	PIK3R1	PIK3R1	PIK3R1	9374	-0.0023	0.31	NO
24	CLTC	CLTC	CLTC	9891	-0.0068	0.28	NO
25	BIRC2	BIRC2	BIRC2	10138	-0.0091	0.27	NO
26	SRC	SRC	SRC	10653	-0.014	0.24	NO
27	MAP3K1	MAP3K1	MAP3K1	10703	-0.014	0.24	NO
28	CHUK	CHUK	CHUK	11383	-0.021	0.21	NO
29	PDPK1	PDPK1	PDPK1	12186	-0.029	0.18	NO
30	MAPK10	MAPK10	MAPK10	12254	-0.03	0.18	NO
31	PIK3R2	PIK3R2	PIK3R2	12317	-0.031	0.19	NO
32	MAP2K6	MAP2K6	MAP2K6	12493	-0.033	0.19	NO
33	MAP2K7	MAP2K7	MAP2K7	12660	-0.036	0.19	NO
34	MAPK9	MAPK9	MAPK9	13400	-0.045	0.16	NO
35	PIK3CA	PIK3CA	PIK3CA	13417	-0.046	0.18	NO
36	PIK3R3	PIK3R3	PIK3R3	14526	-0.065	0.13	NO
37	RFC1	RFC1	RFC1	15252	-0.082	0.12	NO
38	MAPK8	MAPK8	MAPK8	16073	-0.11	0.11	NO

Fold change

For the top enriched genes, if you want to check whether they are

up-regulated, please check the list of up-regulated genes
down-regulated, please check the list of down-regulated genes

Expression level

For the top enriched genes, if you want to check whether they are

highly expressed genes, please check the list of high (top 30%) expressed genes
low expressed genes, please check the list of low (bottom 30%) expressed genes

An expression pattern of top(30%)/middle(30%)/low(30%) in this subtype against other subtypes is available in a heatmap

Significant gene list

For the top enriched genes, if you want to check whether they are

significantly differently expressed genes by eBayes lm fit, please check the list of significant genes

+ Subtype clus2 enriched pathways

Table 4. Get Full Table This table shows top 10 pathways which are significantly enriched in cluster clus2. It displays only significant gene sets satisfying nom.p.val.threshold (-1), fwer.p.val.threshold (-1) , fdr.q.val.threshold (0.25) and the default table is sorted by Normalized Enrichment Score (NES). Further details on NES statistics, please visit The Broad GSEA website.

GeneSet(GS)	Size(#genes)	genes.ES.table	ES	NES	NOM.p.val	FDR.q.val	FWER.p.val	Tag..	Gene..	Signal	FDR..median.	glob.p.val
KEGG HISTIDINE METABOLISM	29	genes.ES.table	0.41	0.97	0.51	1	1	0.45	0.26	0.33	1	0.93
KEGG SNARE INTERACTIONS IN VESICULAR TRANSPORT	38	genes.ES.table	0.3	1.2	0.26	1	1	0.13	0.11	0.12	1	0.96
KEGG HEDGEHOG SIGNALING PATHWAY	54	genes.ES.table	0.37	1	0.43	1	1	0.24	0.13	0.21	1	0.92
KEGG TIGHT JUNCTION	125	genes.ES.table	0.32	1.3	0.12	1	1	0.17	0.12	0.15	1	0.98
KEGG TASTE TRANSDUCTION	35	genes.ES.table	0.41	0.97	0.5	1	1	0.31	0.11	0.28	1	0.92
BIOCARTA ALK PATHWAY	33	genes.ES.table	0.38	1.1	0.31	1	1	0.24	0.15	0.21	1	0.92
BIOCARTA DEATH PATHWAY	33	genes.ES.table	0.27	1	0.46	1	1	0.15	0.17	0.13	1	0.91
PID HDAC CLASSI PATHWAY	65	genes.ES.table	0.22	1.1	0.3	1	1	0.38	0.39	0.24	1	0.96
PID BMPPATHWAY	42	genes.ES.table	0.42	1.2	0.21	1	1	0.24	0.13	0.21	1	0.98
REACTOME SIGNALING BY FGFR1 MUTANTS	25	genes.ES.table	0.36	1.1	0.33	1	1	0.12	0.077	0.11	1	0.92

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	CLDN9	CLDN9	CLDN9	624	0.4	0.065	YES
2	CLDN3	CLDN3	CLDN3	729	0.38	0.15	YES
3	CLDN7	CLDN7	CLDN7	780	0.37	0.24	YES
4	CLDN18	CLDN18	CLDN18	937	0.34	0.32	YES
5	CLDN15	CLDN15	CLDN15	1124	0.31	0.39	YES
6	CLDN20	CLDN20	CLDN20	1307	0.28	0.45	YES
7	CLDN6	CLDN6	CLDN6	1352	0.28	0.52	YES
8	CLDN19	CLDN19	CLDN19	1390	0.27	0.58	YES
9	CLDN4	CLDN4	CLDN4	2965	0.15	0.53	NO
10	PRKCI	PRKCI	PRKCI	4598	0.085	0.46	NO
11	PARD6B	PARD6B	PARD6B	4823	0.079	0.47	NO
12	CRB3	CRB3	CRB3	5321	0.065	0.46	NO
13	CLDN12	CLDN12	CLDN12	5337	0.065	0.47	NO
14	PARD6A	PARD6A	PARD6A	5355	0.064	0.49	NO
15	CLDN1	CLDN1	CLDN1	5878	0.052	0.47	NO
16	CLDN2	CLDN2	CLDN2	6751	0.034	0.43	NO
17	F11R	F11R	F11R	7841	0.013	0.38	NO
18	MPP5	MPP5	MPP5	7932	0.012	0.37	NO
19	CLDN10	CLDN10	CLDN10	8525	0.0021	0.34	NO
20	CLDN14	CLDN14	CLDN14	8711	-0.00093	0.33	NO
21	CLDN16	CLDN16	CLDN16	9894	-0.02	0.27	NO
22	PARD3	PARD3	PARD3	10748	-0.034	0.23	NO
23	INADL	INADL	INADL	10984	-0.038	0.23	NO
24	PARD6G	PARD6G	PARD6G	11803	-0.054	0.2	NO
25	CLDN8	CLDN8	CLDN8	14317	-0.12	0.087	NO
26	CLDN5	CLDN5	CLDN5	14941	-0.16	0.092	NO
27	CLDN11	CLDN11	CLDN11	16853	-0.31	0.063	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	MYH3	MYH3	MYH3	113	0.55	0.028	YES
2	IGSF5	IGSF5	IGSF5	168	0.53	0.056	YES
3	PRKCG	PRKCG	PRKCG	284	0.48	0.079	YES
4	MYH8	MYH8	MYH8	290	0.48	0.11	YES
5	MYH7B	MYH7B	MYH7B	317	0.47	0.14	YES
6	CLDN9	CLDN9	CLDN9	624	0.4	0.14	YES
7	CLDN3	CLDN3	CLDN3	729	0.38	0.16	YES
8	CLDN7	CLDN7	CLDN7	780	0.37	0.18	YES
9	RAB3B	RAB3B	RAB3B	805	0.36	0.2	YES
10	PRKCQ	PRKCQ	PRKCQ	873	0.35	0.22	YES
11	CLDN18	CLDN18	CLDN18	937	0.34	0.23	YES
12	CLDN15	CLDN15	CLDN15	1124	0.31	0.24	YES
13	TJP3	TJP3	TJP3	1277	0.29	0.25	YES
14	CLDN20	CLDN20	CLDN20	1307	0.28	0.27	YES
15	CLDN6	CLDN6	CLDN6	1352	0.28	0.28	YES
16	CLDN19	CLDN19	CLDN19	1390	0.27	0.3	YES
17	GNAI1	GNAI1	GNAI1	1536	0.26	0.3	YES
18	MYH4	MYH4	MYH4	1919	0.22	0.3	YES
19	MAGI2	MAGI2	MAGI2	1940	0.22	0.31	YES
20	OCLN	OCLN	OCLN	2100	0.2	0.31	YES
21	MYH1	MYH1	MYH1	2125	0.2	0.32	YES
22	CLDN4	CLDN4	CLDN4	2965	0.15	0.28	NO
23	LLGL2	LLGL2	LLGL2	3028	0.15	0.29	NO
24	CLDN23	CLDN23	CLDN23	3335	0.13	0.28	NO
25	MYL5	MYL5	MYL5	3526	0.12	0.28	NO
26	PRKCZ	PRKCZ	PRKCZ	3583	0.12	0.28	NO
27	MLLT4	MLLT4	MLLT4	3754	0.11	0.28	NO
28	MYH14	MYH14	MYH14	4206	0.097	0.26	NO
29	MAGI1	MAGI1	MAGI1	4293	0.094	0.26	NO
30	PRKCI	PRKCI	PRKCI	4598	0.085	0.25	NO
31	TJP2	TJP2	TJP2	4658	0.083	0.25	NO
32	CASK	CASK	CASK	4717	0.082	0.25	NO
33	TJP1	TJP1	TJP1	4757	0.08	0.26	NO
34	PARD6B	PARD6B	PARD6B	4823	0.079	0.26	NO
35	KRAS	KRAS	KRAS	5005	0.074	0.25	NO
36	EXOC4	EXOC4	EXOC4	5066	0.072	0.25	NO
37	HRAS	HRAS	HRAS	5153	0.07	0.25	NO
38	CRB3	CRB3	CRB3	5321	0.065	0.25	NO
39	PARD6A	PARD6A	PARD6A	5355	0.064	0.25	NO
40	EPB41L1	EPB41L1	EPB41L1	5567	0.059	0.24	NO
41	MYL12B	MYL12B	MYL12B	5875	0.052	0.23	NO
42	CLDN1	CLDN1	CLDN1	5878	0.052	0.23	NO
43	AKT2	AKT2	AKT2	6016	0.049	0.22	NO
44	CSDA	CSDA	CSDA	6543	0.038	0.2	NO
45	MRAS	MRAS	MRAS	6572	0.037	0.2	NO
46	AMOTL1	AMOTL1	AMOTL1	6618	0.036	0.2	NO
47	AKT1	AKT1	AKT1	6640	0.036	0.2	NO
48	CLDN2	CLDN2	CLDN2	6751	0.034	0.19	NO
49	SYMPK	SYMPK	SYMPK	6833	0.032	0.19	NO
50	TJAP1	TJAP1	TJAP1	6888	0.031	0.19	NO
51	PRKCA	PRKCA	PRKCA	7256	0.024	0.17	NO
52	CTTN	CTTN	CTTN	7273	0.024	0.17	NO
53	LLGL1	LLGL1	LLGL1	7456	0.021	0.16	NO
54	F11R	F11R	F11R	7841	0.013	0.14	NO
55	EPB41L2	EPB41L2	EPB41L2	7903	0.012	0.14	NO
56	RHOA	RHOA	RHOA	7916	0.012	0.14	NO
57	MPP5	MPP5	MPP5	7932	0.012	0.14	NO
58	SPTAN1	SPTAN1	SPTAN1	8063	0.0094	0.13	NO
59	CTNNA1	CTNNA1	CTNNA1	8114	0.0085	0.13	NO
60	MYLPF	MYLPF	MYLPF	8264	0.006	0.12	NO
61	ACTB	ACTB	ACTB	8332	0.005	0.12	NO
62	MYL12A	MYL12A	MYL12A	8421	0.0035	0.12	NO
63	CLDN10	CLDN10	CLDN10	8525	0.0021	0.11	NO
64	MYH15	MYH15	MYH15	8646	0.00015	0.1	NO
65	CLDN14	CLDN14	CLDN14	8711	-0.00093	0.099	NO
66	RAB13	RAB13	RAB13	8716	-0.0011	0.098	NO
67	ASH1L	ASH1L	ASH1L	8732	-0.0012	0.098	NO
68	RRAS	RRAS	RRAS	8792	-0.0023	0.095	NO
69	SRC	SRC	SRC	8822	-0.0028	0.093	NO
70	CSNK2B	CSNK2B	CSNK2B	8897	-0.004	0.089	NO
71	MAGI3	MAGI3	MAGI3	9298	-0.01	0.068	NO
72	EXOC3	EXOC3	EXOC3	9302	-0.01	0.068	NO
73	PPP2R1A	PPP2R1A	PPP2R1A	9312	-0.011	0.068	NO
74	MYL9	MYL9	MYL9	9502	-0.014	0.058	NO
75	CDC42	CDC42	CDC42	9575	-0.015	0.055	NO
76	AKT3	AKT3	AKT3	9868	-0.02	0.04	NO
77	CLDN16	CLDN16	CLDN16	9894	-0.02	0.04	NO
78	RRAS2	RRAS2	RRAS2	9924	-0.02	0.04	NO
79	MYH10	MYH10	MYH10	9950	-0.021	0.039	NO
80	YES1	YES1	YES1	10277	-0.026	0.023	NO
81	CSNK2A2	CSNK2A2	CSNK2A2	10382	-0.028	0.019	NO
82	MYH2	MYH2	MYH2	10411	-0.028	0.019	NO
83	GNAI3	GNAI3	GNAI3	10441	-0.029	0.019	NO
84	PPP2R2D	PPP2R2D	PPP2R2D	10470	-0.029	0.019	NO
85	PTEN	PTEN	PTEN	10639	-0.032	0.012	NO
86	PARD3	PARD3	PARD3	10748	-0.034	0.0077	NO
87	CTNNB1	CTNNB1	CTNNB1	10869	-0.036	0.0031	NO
88	INADL	INADL	INADL	10984	-0.038	-0.00094	NO
89	VAPA	VAPA	VAPA	11297	-0.043	-0.016	NO
90	GNAI2	GNAI2	GNAI2	11375	-0.045	-0.017	NO
91	EPB41L3	EPB41L3	EPB41L3	11392	-0.045	-0.016	NO
92	ACTG1	ACTG1	ACTG1	11473	-0.047	-0.017	NO
93	ACTN4	ACTN4	ACTN4	11476	-0.047	-0.014	NO
94	PPP2R1B	PPP2R1B	PPP2R1B	11547	-0.049	-0.015	NO
95	PPP2CA	PPP2CA	PPP2CA	11620	-0.05	-0.016	NO
96	CSNK2A1	CSNK2A1	CSNK2A1	11709	-0.052	-0.018	NO
97	PARD6G	PARD6G	PARD6G	11803	-0.054	-0.02	NO
98	PPP2CB	PPP2CB	PPP2CB	12001	-0.058	-0.027	NO
99	MPDZ	MPDZ	MPDZ	12759	-0.074	-0.065	NO
100	MYH9	MYH9	MYH9	12895	-0.078	-0.068	NO
101	CGN	CGN	CGN	12909	-0.078	-0.064	NO
102	CDK4	CDK4	CDK4	13017	-0.081	-0.065	NO
103	EPB41	EPB41	EPB41	13563	-0.097	-0.09	NO
104	NRAS	NRAS	NRAS	13612	-0.098	-0.086	NO
105	ZAK	ZAK	ZAK	13629	-0.099	-0.081	NO
106	PRKCD	PRKCD	PRKCD	13701	-0.1	-0.079	NO
107	ACTN1	ACTN1	ACTN1	13711	-0.1	-0.073	NO
108	ACTN2	ACTN2	ACTN2	14186	-0.12	-0.093	NO
109	PPP2R2A	PPP2R2A	PPP2R2A	14296	-0.12	-0.091	NO
110	CLDN8	CLDN8	CLDN8	14317	-0.12	-0.085	NO
111	CLDN5	CLDN5	CLDN5	14941	-0.16	-0.11	NO
112	MYH7	MYH7	MYH7	15041	-0.16	-0.11	NO
113	ACTN3	ACTN3	ACTN3	15479	-0.2	-0.12	NO
114	HCLS1	HCLS1	HCLS1	15822	-0.22	-0.12	NO
115	CTNNA3	CTNNA3	CTNNA3	16536	-0.28	-0.15	NO
116	JAM2	JAM2	JAM2	16735	-0.3	-0.14	NO
117	CLDN11	CLDN11	CLDN11	16853	-0.31	-0.13	NO
118	JAM3	JAM3	JAM3	16873	-0.31	-0.11	NO
119	PRKCE	PRKCE	PRKCE	16999	-0.32	-0.097	NO
120	CTNNA2	CTNNA2	CTNNA2	17043	-0.33	-0.08	NO
121	PRKCH	PRKCH	PRKCH	17185	-0.35	-0.066	NO
122	PRKCB	PRKCB	PRKCB	17643	-0.44	-0.066	NO
123	MYH11	MYH11	MYH11	17661	-0.44	-0.04	NO
124	PPP2R2B	PPP2R2B	PPP2R2B	17669	-0.44	-0.013	NO
125	PPP2R2C	PPP2R2C	PPP2R2C	17798	-0.5	0.01	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	SOSTDC1	SOSTDC1	SOSTDC1	66	0.6	0.089	YES
2	BMP6	BMP6	BMP6	154	0.53	0.16	YES
3	NOG	NOG	NOG	276	0.48	0.23	YES
4	BMP4	BMP4	BMP4	512	0.42	0.28	YES
5	SMAD6	SMAD6	SMAD6	577	0.41	0.34	YES
6	SMAD9	SMAD9	SMAD9	1275	0.29	0.35	YES
7	BAMBI	BAMBI	BAMBI	1344	0.28	0.39	YES
8	SMAD7	SMAD7	SMAD7	1971	0.22	0.38	YES
9	BMP7	BMP7	BMP7	2167	0.2	0.4	YES
10	BMP2	BMP2	BMP2	2350	0.19	0.42	YES
11	HFE2	HFE2	HFE2	3644	0.12	0.37	NO
12	SKI	SKI	SKI	4079	0.1	0.36	NO
13	SMURF2	SMURF2	SMURF2	4358	0.092	0.36	NO
14	TAB1	TAB1	TAB1	4806	0.079	0.35	NO
15	CER1	CER1	CER1	5206	0.068	0.33	NO
16	SMAD4	SMAD4	SMAD4	5430	0.062	0.33	NO
17	NUP214	NUP214	NUP214	6427	0.04	0.28	NO
18	SMURF1	SMURF1	SMURF1	6442	0.04	0.29	NO
19	PPP1R15A	PPP1R15A	PPP1R15A	6458	0.04	0.29	NO
20	BMPR1A	BMPR1A	BMPR1A	7697	0.016	0.23	NO
21	SMAD5	SMAD5	SMAD5	7715	0.016	0.23	NO
22	CTDSP1	CTDSP1	CTDSP1	7738	0.015	0.23	NO
23	ZFYVE16	ZFYVE16	ZFYVE16	8271	0.006	0.2	NO
24	PPP1CA	PPP1CA	PPP1CA	8738	-0.0014	0.17	NO
25	RGMB	RGMB	RGMB	8791	-0.0023	0.17	NO
26	GSK3B	GSK3B	GSK3B	9148	-0.0079	0.15	NO
27	CTDSPL	CTDSPL	CTDSPL	9199	-0.0089	0.15	NO
28	CTDSP2	CTDSP2	CTDSP2	9582	-0.015	0.13	NO
29	MAP3K7	MAP3K7	MAP3K7	9731	-0.018	0.13	NO
30	BMPR2	BMPR2	BMPR2	9866	-0.02	0.12	NO
31	XIAP	XIAP	XIAP	10096	-0.023	0.11	NO
32	SMAD1	SMAD1	SMAD1	10210	-0.025	0.11	NO
33	MAPK1	MAPK1	MAPK1	10337	-0.027	0.11	NO
34	PPM1A	PPM1A	PPM1A	10669	-0.032	0.094	NO
35	AHSG	AHSG	AHSG	14279	-0.12	-0.088	NO
36	TAB2	TAB2	TAB2	14367	-0.13	-0.074	NO
37	RGMA	RGMA	RGMA	14472	-0.13	-0.059	NO
38	CHRD	CHRD	CHRD	14595	-0.14	-0.045	NO
39	BMPR1B	BMPR1B	BMPR1B	16403	-0.27	-0.1	NO
40	CHRDL1	CHRDL1	CHRDL1	17508	-0.41	-0.1	NO
41	FST	FST	FST	17528	-0.41	-0.042	NO
42	GREM1	GREM1	GREM1	17654	-0.44	0.018	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	VAMP1	VAMP1	VAMP1	1045	0.32	0.036	YES
2	STX1A	STX1A	STX1A	1163	0.3	0.12	YES
3	SNAP25	SNAP25	SNAP25	1272	0.29	0.2	YES
4	STX19	STX19	STX19	1705	0.24	0.24	YES
5	STX1B	STX1B	STX1B	1908	0.22	0.3	YES
6	STX2	STX2	STX2	3184	0.14	0.27	NO
7	STX16	STX16	STX16	3965	0.1	0.26	NO
8	STX10	STX10	STX10	5091	0.071	0.21	NO
9	VAMP2	VAMP2	VAMP2	5136	0.07	0.23	NO
10	STX8	STX8	STX8	5522	0.06	0.23	NO
11	VAMP5	VAMP5	VAMP5	5558	0.059	0.24	NO
12	VAMP4	VAMP4	VAMP4	5685	0.056	0.25	NO
13	YKT6	YKT6	YKT6	7080	0.028	0.18	NO
14	TSNARE1	TSNARE1	TSNARE1	7378	0.022	0.17	NO
15	STX18	STX18	STX18	7551	0.019	0.17	NO
16	STX17	STX17	STX17	8151	0.0079	0.14	NO
17	BET1	BET1	BET1	8218	0.0068	0.14	NO
18	VAMP8	VAMP8	VAMP8	8326	0.0051	0.13	NO
19	GOSR1	GOSR1	GOSR1	8468	0.0028	0.13	NO
20	STX4	STX4	STX4	8477	0.0026	0.13	NO
21	BET1L	BET1L	BET1L	9211	-0.0091	0.088	NO
22	VTI1B	VTI1B	VTI1B	9754	-0.018	0.063	NO
23	STX5	STX5	STX5	9873	-0.02	0.062	NO
24	SNAP47	SNAP47	SNAP47	10143	-0.024	0.054	NO
25	STX3	STX3	STX3	10282	-0.026	0.054	NO
26	STX7	STX7	STX7	10538	-0.03	0.049	NO
27	VAMP3	VAMP3	VAMP3	10853	-0.036	0.042	NO
28	SNAP29	SNAP29	SNAP29	10986	-0.038	0.046	NO
29	USE1	USE1	USE1	11180	-0.041	0.047	NO
30	STX12	STX12	STX12	12049	-0.059	0.016	NO
31	SNAP23	SNAP23	SNAP23	12147	-0.061	0.029	NO
32	GOSR2	GOSR2	GOSR2	12475	-0.068	0.03	NO
33	STX6	STX6	STX6	13557	-0.096	-0.0014	NO
34	SEC22B	SEC22B	SEC22B	14171	-0.12	-0.00064	NO
35	BNIP1	BNIP1	BNIP1	14193	-0.12	0.033	NO
36	VTI1A	VTI1A	VTI1A	14372	-0.13	0.061	NO
37	VAMP7	VAMP7	VAMP7	14431	-0.13	0.096	NO
38	STX11	STX11	STX11	17182	-0.35	0.044	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	NR2E3	NR2E3	NR2E3	83	0.58	0.01	YES
2	ZNF577	ZNF577	ZNF577	124	0.55	0.022	YES
3	ZNF167	ZNF167	ZNF167	363	0.46	0.02	YES
4	ZNF334	ZNF334	ZNF334	399	0.45	0.03	YES
5	ZNF300	ZNF300	ZNF300	649	0.39	0.026	YES
6	ZNF540	ZNF540	ZNF540	680	0.39	0.034	YES
7	ZFP2	ZFP2	ZFP2	712	0.38	0.042	YES
8	ZNF439	ZNF439	ZNF439	761	0.37	0.049	YES
9	ZNF596	ZNF596	ZNF596	826	0.36	0.055	YES
10	ZNF273	ZNF273	ZNF273	1010	0.33	0.053	YES
11	ZNF471	ZNF471	ZNF471	1060	0.32	0.058	YES
12	ZNF23	ZNF23	ZNF23	1073	0.32	0.066	YES
13	ZNF157	ZNF157	ZNF157	1118	0.31	0.071	YES
14	ZFP28	ZFP28	ZFP28	1138	0.31	0.078	YES
15	ZNF547	ZNF547	ZNF547	1180	0.3	0.084	YES
16	ZNF625	ZNF625	ZNF625	1228	0.29	0.088	YES
17	ZNF141	ZNF141	ZNF141	1419	0.27	0.085	YES
18	MAMLD1	MAMLD1	MAMLD1	1442	0.27	0.09	YES
19	ZNF519	ZNF519	ZNF519	1472	0.26	0.096	YES
20	ZNF169	ZNF169	ZNF169	1528	0.26	0.099	YES
21	ZNF493	ZNF493	ZNF493	1552	0.26	0.1	YES
22	ZNF433	ZNF433	ZNF433	1562	0.26	0.11	YES
23	TEAD2	TEAD2	TEAD2	1570	0.26	0.12	YES
24	ZNF454	ZNF454	ZNF454	1579	0.25	0.12	YES
25	ZNF337	ZNF337	ZNF337	1599	0.25	0.13	YES
26	ZNF320	ZNF320	ZNF320	1713	0.24	0.13	YES
27	ZNF599	ZNF599	ZNF599	1736	0.24	0.13	YES
28	ZNF425	ZNF425	ZNF425	1774	0.24	0.14	YES
29	RORA	RORA	RORA	1840	0.23	0.14	YES
30	ZNF558	ZNF558	ZNF558	1841	0.23	0.14	YES
31	ZNF311	ZNF311	ZNF311	1844	0.23	0.15	YES
32	ESR2	ESR2	ESR2	1871	0.23	0.16	YES
33	ZNF443	ZNF443	ZNF443	1894	0.23	0.16	YES
34	ZNF354B	ZNF354B	ZNF354B	1947	0.22	0.16	YES
35	ZNF214	ZNF214	ZNF214	1952	0.22	0.17	YES
36	ZNF530	ZNF530	ZNF530	1957	0.22	0.17	YES
37	ZNF287	ZNF287	ZNF287	1961	0.22	0.18	YES
38	SMAD7	SMAD7	SMAD7	1971	0.22	0.18	YES
39	KAT2A	KAT2A	KAT2A	1973	0.22	0.19	YES
40	ZNF442	ZNF442	ZNF442	1982	0.22	0.2	YES
41	ZNF19	ZNF19	ZNF19	1999	0.22	0.2	YES
42	ZNF441	ZNF441	ZNF441	2002	0.22	0.2	YES
43	ZNF620	ZNF620	ZNF620	2006	0.22	0.21	YES
44	ZNF382	ZNF382	ZNF382	2022	0.21	0.22	YES
45	HNF4A	HNF4A	HNF4A	2042	0.21	0.22	YES
46	ZNF546	ZNF546	ZNF546	2051	0.21	0.22	YES
47	NPPA	NPPA	NPPA	2066	0.21	0.23	YES
48	ZFP37	ZFP37	ZFP37	2104	0.2	0.23	YES
49	ZNF266	ZNF266	ZNF266	2111	0.2	0.24	YES
50	NR1I2	NR1I2	NR1I2	2204	0.2	0.24	YES
51	ZNF211	ZNF211	ZNF211	2254	0.19	0.24	YES
52	SMARCD3	SMARCD3	SMARCD3	2285	0.19	0.24	YES
53	ZNF498	ZNF498	ZNF498	2287	0.19	0.25	YES
54	ZNF483	ZNF483	ZNF483	2363	0.18	0.25	YES
55	HNF4G	HNF4G	HNF4G	2382	0.18	0.25	YES
56	ZNF160	ZNF160	ZNF160	2386	0.18	0.26	YES
57	ZNF514	ZNF514	ZNF514	2392	0.18	0.26	YES
58	ZNF92	ZNF92	ZNF92	2423	0.18	0.26	YES
59	ZNF606	ZNF606	ZNF606	2453	0.18	0.27	YES
60	ZNF10	ZNF10	ZNF10	2455	0.18	0.27	YES
61	RARA	RARA	RARA	2500	0.18	0.27	YES
62	ZNF517	ZNF517	ZNF517	2532	0.17	0.28	YES
63	ZNF212	ZNF212	ZNF212	2611	0.17	0.28	YES
64	ZNF224	ZNF224	ZNF224	2631	0.17	0.28	YES
65	ZNF655	ZNF655	ZNF655	2678	0.16	0.28	YES
66	ZNF419	ZNF419	ZNF419	2803	0.16	0.28	YES
67	ZNF250	ZNF250	ZNF250	2815	0.16	0.28	YES
68	ZNF354C	ZNF354C	ZNF354C	2842	0.16	0.28	YES
69	ZNF708	ZNF708	ZNF708	2886	0.15	0.28	YES
70	ZNF446	ZNF446	ZNF446	2906	0.15	0.29	YES
71	ZNF3	ZNF3	ZNF3	2973	0.15	0.29	YES
72	ZNF235	ZNF235	ZNF235	2974	0.15	0.29	YES
73	ZNF43	ZNF43	ZNF43	2983	0.15	0.3	YES
74	ZNF621	ZNF621	ZNF621	3006	0.15	0.3	YES
75	ZNF624	ZNF624	ZNF624	3021	0.15	0.3	YES
76	ZNF234	ZNF234	ZNF234	3059	0.14	0.3	YES
77	ZNF605	ZNF605	ZNF605	3069	0.14	0.3	YES
78	PPARD	PPARD	PPARD	3092	0.14	0.31	YES
79	ZKSCAN5	ZKSCAN5	ZKSCAN5	3135	0.14	0.31	YES
80	ZNF415	ZNF415	ZNF415	3182	0.14	0.31	YES
81	ZNF559	ZNF559	ZNF559	3251	0.14	0.31	YES
82	ZNF26	ZNF26	ZNF26	3269	0.14	0.31	YES
83	ZNF12	ZNF12	ZNF12	3311	0.13	0.31	YES
84	ZFP90	ZFP90	ZFP90	3367	0.13	0.31	YES
85	ZNF528	ZNF528	ZNF528	3370	0.13	0.32	YES
86	ZNF285	ZNF285	ZNF285	3442	0.13	0.32	YES
87	ZNF30	ZNF30	ZNF30	3497	0.12	0.32	YES
88	ZNF248	ZNF248	ZNF248	3508	0.12	0.32	YES
89	ZNF100	ZNF100	ZNF100	3514	0.12	0.32	YES
90	ZNF610	ZNF610	ZNF610	3519	0.12	0.32	YES
91	ZNF226	ZNF226	ZNF226	3579	0.12	0.32	YES
92	ZNF18	ZNF18	ZNF18	3595	0.12	0.33	YES
93	ZNF221	ZNF221	ZNF221	3606	0.12	0.33	YES
94	ZNF582	ZNF582	ZNF582	3609	0.12	0.33	YES
95	ZNF347	ZNF347	ZNF347	3647	0.12	0.33	YES
96	ZKSCAN3	ZKSCAN3	ZKSCAN3	3660	0.12	0.34	YES
97	AR	AR	AR	3661	0.12	0.34	YES
98	ZNF202	ZNF202	ZNF202	3700	0.12	0.34	YES
99	THRA	THRA	THRA	3713	0.12	0.34	YES
100	ZNF658	ZNF658	ZNF658	3715	0.12	0.34	YES
101	ZNF440	ZNF440	ZNF440	3743	0.11	0.35	YES
102	ZNF607	ZNF607	ZNF607	3763	0.11	0.35	YES
103	ZNF571	ZNF571	ZNF571	3764	0.11	0.35	YES
104	CCNT2	CCNT2	CCNT2	3864	0.11	0.35	YES
105	ZNF600	ZNF600	ZNF600	3926	0.11	0.35	YES
106	ZNF642	ZNF642	ZNF642	3937	0.11	0.35	YES
107	ZNF138	ZNF138	ZNF138	3980	0.1	0.35	YES
108	ZNF417	ZNF417	ZNF417	3993	0.1	0.35	YES
109	ZNF506	ZNF506	ZNF506	4030	0.1	0.35	YES
110	ZNF274	ZNF274	ZNF274	4077	0.1	0.35	YES
111	SP1	SP1	SP1	4078	0.1	0.36	YES
112	SKI	SKI	SKI	4079	0.1	0.36	YES
113	ZNF264	ZNF264	ZNF264	4154	0.098	0.36	YES
114	ZNF175	ZNF175	ZNF175	4181	0.098	0.36	YES
115	ZNF282	ZNF282	ZNF282	4225	0.096	0.36	YES
116	ZNF155	ZNF155	ZNF155	4237	0.096	0.36	YES
117	ZNF529	ZNF529	ZNF529	4274	0.095	0.36	YES
118	CDK9	CDK9	CDK9	4301	0.094	0.36	YES
119	ZNF286A	ZNF286A	ZNF286A	4324	0.093	0.36	YES
120	ZKSCAN1	ZKSCAN1	ZKSCAN1	4327	0.093	0.36	YES
121	ZNF418	ZNF418	ZNF418	4328	0.093	0.37	YES
122	NR2C2AP	NR2C2AP	NR2C2AP	4347	0.092	0.37	YES
123	ZNF585B	ZNF585B	ZNF585B	4356	0.092	0.37	YES
124	SMURF2	SMURF2	SMURF2	4358	0.092	0.37	YES
125	ZNF544	ZNF544	ZNF544	4360	0.092	0.37	YES
126	MED31	MED31	MED31	4441	0.09	0.37	YES
127	ZNF354A	ZNF354A	ZNF354A	4459	0.089	0.37	YES
128	TGIF1	TGIF1	TGIF1	4485	0.088	0.37	YES
129	ZNF140	ZNF140	ZNF140	4505	0.088	0.38	YES
130	ZNF205	ZNF205	ZNF205	4571	0.086	0.37	YES
131	RARG	RARG	RARG	4604	0.085	0.37	YES
132	ZIK1	ZIK1	ZIK1	4607	0.085	0.38	YES
133	ZNF394	ZNF394	ZNF394	4630	0.084	0.38	YES
134	ZNF432	ZNF432	ZNF432	4663	0.083	0.38	YES
135	ZNF256	ZNF256	ZNF256	4671	0.083	0.38	YES
136	ZNF569	ZNF569	ZNF569	4704	0.082	0.38	YES
137	ZNF333	ZNF333	ZNF333	4718	0.082	0.38	YES
138	ZNF611	ZNF611	ZNF611	4767	0.08	0.38	YES
139	ZNF223	ZNF223	ZNF223	4886	0.077	0.38	YES
140	ZNF2	ZNF2	ZNF2	4930	0.076	0.38	YES
141	ZNF215	ZNF215	ZNF215	4943	0.075	0.38	YES
142	ZNF587	ZNF587	ZNF587	4970	0.075	0.38	YES
143	ZNF254	ZNF254	ZNF254	5014	0.073	0.38	YES
144	ZNF566	ZNF566	ZNF566	5080	0.072	0.37	YES
145	ZNF343	ZNF343	ZNF343	5084	0.072	0.38	YES
146	ZNF33B	ZNF33B	ZNF33B	5102	0.071	0.38	YES
147	ZNF510	ZNF510	ZNF510	5103	0.071	0.38	YES
148	ZNF20	ZNF20	ZNF20	5124	0.07	0.38	YES
149	NR1D1	NR1D1	NR1D1	5126	0.07	0.38	YES
150	ZNF213	ZNF213	ZNF213	5127	0.07	0.38	YES
151	ZNF398	ZNF398	ZNF398	5195	0.069	0.38	NO
152	ZFP112	ZFP112	ZFP112	5213	0.068	0.38	NO
153	NR6A1	NR6A1	NR6A1	5313	0.065	0.38	NO
154	TEAD4	TEAD4	TEAD4	5384	0.064	0.38	NO
155	TEAD3	TEAD3	TEAD3	5402	0.063	0.38	NO
156	SMAD4	SMAD4	SMAD4	5430	0.062	0.38	NO
157	ZNF37A	ZNF37A	ZNF37A	5436	0.062	0.38	NO
158	NCOR1	NCOR1	NCOR1	5583	0.059	0.37	NO
159	MED4	MED4	MED4	5605	0.058	0.37	NO
160	ZNF589	ZNF589	ZNF589	5606	0.058	0.37	NO
161	ZNF557	ZNF557	ZNF557	5608	0.058	0.37	NO
162	ZNF551	ZNF551	ZNF551	5698	0.056	0.37	NO
163	ZNF431	ZNF431	ZNF431	5706	0.056	0.37	NO
164	ZNF567	ZNF567	ZNF567	5772	0.054	0.37	NO
165	ZKSCAN4	ZKSCAN4	ZKSCAN4	5804	0.054	0.37	NO
166	ZNF383	ZNF383	ZNF383	5834	0.053	0.37	NO
167	ZNF500	ZNF500	ZNF500	5902	0.051	0.37	NO
168	ZNF33A	ZNF33A	ZNF33A	5907	0.051	0.37	NO
169	ZNF434	ZNF434	ZNF434	5948	0.051	0.37	NO
170	MEN1	MEN1	MEN1	5972	0.05	0.37	NO
171	MAML3	MAML3	MAML3	6042	0.049	0.36	NO
172	ZNF445	ZNF445	ZNF445	6083	0.048	0.36	NO
173	ZNF17	ZNF17	ZNF17	6143	0.047	0.36	NO
174	ZNF480	ZNF480	ZNF480	6156	0.046	0.36	NO
175	NOTCH2	NOTCH2	NOTCH2	6191	0.046	0.36	NO
176	ZFP1	ZFP1	ZFP1	6201	0.046	0.36	NO
177	ZNF564	ZNF564	ZNF564	6219	0.045	0.36	NO
178	MED17	MED17	MED17	6275	0.044	0.36	NO
179	NR1D2	NR1D2	NR1D2	6304	0.043	0.36	NO
180	HDAC1	HDAC1	HDAC1	6307	0.043	0.36	NO
181	ZNF649	ZNF649	ZNF649	6328	0.043	0.36	NO
182	ZNF197	ZNF197	ZNF197	6336	0.043	0.36	NO
183	ZNF225	ZNF225	ZNF225	6397	0.041	0.36	NO
184	ZNF263	ZNF263	ZNF263	6605	0.036	0.35	NO
185	ZNF773	ZNF773	ZNF773	6615	0.036	0.35	NO
186	MED15	MED15	MED15	6660	0.035	0.35	NO
187	ZNF565	ZNF565	ZNF565	6680	0.035	0.34	NO
188	MED24	MED24	MED24	6777	0.033	0.34	NO
189	ZNF485	ZNF485	ZNF485	6804	0.032	0.34	NO
190	ZNF25	ZNF25	ZNF25	6830	0.032	0.34	NO
191	SMAD3	SMAD3	SMAD3	6845	0.032	0.34	NO
192	ZNF627	ZNF627	ZNF627	6846	0.032	0.34	NO
193	MAML2	MAML2	MAML2	6853	0.032	0.34	NO
194	PPARG	PPARG	PPARG	6890	0.031	0.34	NO
195	NCOA3	NCOA3	NCOA3	7044	0.028	0.33	NO
196	ZNF136	ZNF136	ZNF136	7071	0.028	0.33	NO
197	NR2F6	NR2F6	NR2F6	7097	0.027	0.33	NO
198	ZNF304	ZNF304	ZNF304	7100	0.027	0.33	NO
199	MED23	MED23	MED23	7187	0.026	0.33	NO
200	ZNF331	ZNF331	ZNF331	7254	0.024	0.32	NO
201	TRIM33	TRIM33	TRIM33	7264	0.024	0.32	NO
202	ESRRG	ESRRG	ESRRG	7278	0.024	0.32	NO
203	ZNF585A	ZNF585A	ZNF585A	7302	0.023	0.32	NO
204	RXRB	RXRB	RXRB	7482	0.02	0.31	NO
205	ESRRA	ESRRA	ESRRA	7530	0.019	0.31	NO
206	RBPJ	RBPJ	RBPJ	7564	0.018	0.31	NO
207	ZNF570	ZNF570	ZNF570	7567	0.018	0.31	NO
208	MED7	MED7	MED7	7635	0.017	0.31	NO
209	ZNF548	ZNF548	ZNF548	7696	0.016	0.3	NO
210	MED26	MED26	MED26	7781	0.014	0.3	NO
211	MED27	MED27	MED27	7834	0.014	0.3	NO
212	NRBP1	NRBP1	NRBP1	7848	0.013	0.3	NO
213	ZNF490	ZNF490	ZNF490	7872	0.013	0.3	NO
214	ZNF324	ZNF324	ZNF324	7873	0.013	0.3	NO
215	ZNF563	ZNF563	ZNF563	7885	0.013	0.3	NO
216	MED25	MED25	MED25	8013	0.01	0.29	NO
217	ZNF200	ZNF200	ZNF200	8066	0.0093	0.29	NO
218	TBL1XR1	TBL1XR1	TBL1XR1	8094	0.0089	0.28	NO
219	ZNF101	ZNF101	ZNF101	8103	0.0086	0.28	NO
220	NR1H2	NR1H2	NR1H2	8117	0.0084	0.28	NO
221	ZNF230	ZNF230	ZNF230	8220	0.0066	0.28	NO
222	ZNF595	ZNF595	ZNF595	8221	0.0066	0.28	NO
223	CREBBP	CREBBP	CREBBP	8279	0.0058	0.28	NO
224	NCOA6	NCOA6	NCOA6	8321	0.0052	0.27	NO
225	MAML1	MAML1	MAML1	8416	0.0036	0.27	NO
226	ZNF615	ZNF615	ZNF615	8427	0.0034	0.27	NO
227	ZNF556	ZNF556	ZNF556	8476	0.0026	0.26	NO
228	E2F4	E2F4	E2F4	8533	0.0019	0.26	NO
229	ZNF180	ZNF180	ZNF180	8590	0.0011	0.26	NO
230	ZNF468	ZNF468	ZNF468	8619	0.00063	0.26	NO
231	ZNF436	ZNF436	ZNF436	8701	-0.0008	0.25	NO
232	ZNF555	ZNF555	ZNF555	8707	-0.00087	0.25	NO
233	ZNF583	ZNF583	ZNF583	8825	-0.0029	0.24	NO
234	ZNF192	ZNF192	ZNF192	8927	-0.0044	0.24	NO
235	ZNF543	ZNF543	ZNF543	8961	-0.0048	0.24	NO
236	ZNF267	ZNF267	ZNF267	9095	-0.0071	0.23	NO
237	RUNX2	RUNX2	RUNX2	9252	-0.0096	0.22	NO
238	ZNF28	ZNF28	ZNF28	9256	-0.0096	0.22	NO
239	TFDP1	TFDP1	TFDP1	9311	-0.011	0.22	NO
240	ZNF597	ZNF597	ZNF597	9314	-0.011	0.22	NO
241	ZNF613	ZNF613	ZNF613	9381	-0.012	0.22	NO
242	TBL1X	TBL1X	TBL1X	9386	-0.012	0.22	NO
243	ZNF189	ZNF189	ZNF189	9408	-0.012	0.22	NO
244	MED6	MED6	MED6	9505	-0.014	0.21	NO
245	CTGF	CTGF	CTGF	9595	-0.016	0.21	NO
246	ZNF561	ZNF561	ZNF561	9764	-0.018	0.2	NO
247	SMAD2	SMAD2	SMAD2	9784	-0.018	0.2	NO
248	MED1	MED1	MED1	9793	-0.019	0.2	NO
249	TGIF2	TGIF2	TGIF2	9833	-0.019	0.19	NO
250	ZNF154	ZNF154	ZNF154	9884	-0.02	0.19	NO
251	ZNF317	ZNF317	ZNF317	9904	-0.02	0.19	NO
252	ZIM2	ZIM2	ZIM2	9905	-0.02	0.19	NO
253	MED12	MED12	MED12	9915	-0.02	0.19	NO
254	TRIM28	TRIM28	TRIM28	9917	-0.02	0.19	NO
255	TEAD1	TEAD1	TEAD1	9956	-0.021	0.19	NO
256	ZNF184	ZNF184	ZNF184	10082	-0.023	0.18	NO
257	ZNF208	ZNF208	ZNF208	10126	-0.024	0.18	NO
258	ZNF492	ZNF492	ZNF492	10179	-0.024	0.18	NO
259	MED16	MED16	MED16	10276	-0.026	0.18	NO
260	ZNF484	ZNF484	ZNF484	10297	-0.026	0.18	NO
261	ZNF584	ZNF584	ZNF584	10333	-0.027	0.17	NO
262	PPARA	PPARA	PPARA	10431	-0.029	0.17	NO
263	SNW1	SNW1	SNW1	10463	-0.029	0.17	NO
264	RORC	RORC	RORC	10483	-0.03	0.17	NO
265	WWTR1	WWTR1	WWTR1	10605	-0.031	0.16	NO
266	PPM1A	PPM1A	PPM1A	10669	-0.032	0.16	NO
267	ZNF227	ZNF227	ZNF227	10674	-0.033	0.16	NO
268	ZNF416	ZNF416	ZNF416	10761	-0.034	0.16	NO
269	MED14	MED14	MED14	10782	-0.034	0.16	NO
270	MED8	MED8	MED8	10891	-0.036	0.15	NO
271	ZNF45	ZNF45	ZNF45	10919	-0.037	0.15	NO
272	NCOR2	NCOR2	NCOR2	10987	-0.038	0.15	NO
273	YAP1	YAP1	YAP1	11057	-0.039	0.14	NO
274	ZNF14	ZNF14	ZNF14	11077	-0.039	0.14	NO
275	ZNF614	ZNF614	ZNF614	11200	-0.042	0.14	NO
276	ZNF222	ZNF222	ZNF222	11207	-0.042	0.14	NO
277	MED10	MED10	MED10	11219	-0.042	0.14	NO
278	CCNC	CCNC	CCNC	11526	-0.048	0.12	NO
279	E2F5	E2F5	E2F5	11563	-0.049	0.12	NO
280	UBE2D3	UBE2D3	UBE2D3	11585	-0.05	0.12	NO
281	NCOA1	NCOA1	NCOA1	11611	-0.05	0.12	NO
282	UBA52	UBA52	UBA52	11636	-0.051	0.12	NO
283	THRB	THRB	THRB	11656	-0.051	0.12	NO
284	PRIC285	PRIC285	PRIC285	11754	-0.053	0.12	NO
285	ZNF473	ZNF473	ZNF473	11949	-0.057	0.11	NO
286	ZNF496	ZNF496	ZNF496	12076	-0.06	0.1	NO
287	ZNF616	ZNF616	ZNF616	12081	-0.06	0.1	NO
288	NR1I3	NR1I3	NR1I3	12127	-0.061	0.1	NO
289	ZNF114	ZNF114	ZNF114	12190	-0.062	0.1	NO
290	ZNF552	ZNF552	ZNF552	12238	-0.063	0.1	NO
291	TGS1	TGS1	TGS1	12453	-0.068	0.09	NO
292	ZNF350	ZNF350	ZNF350	12492	-0.068	0.09	NO
293	RPS27A	RPS27A	RPS27A	12534	-0.069	0.089	NO
294	MED20	MED20	MED20	12628	-0.071	0.086	NO
295	NR3C2	NR3C2	NR3C2	12674	-0.072	0.085	NO
296	NR3C1	NR3C1	NR3C1	12902	-0.078	0.074	NO
297	NR1H3	NR1H3	NR1H3	12960	-0.08	0.073	NO
298	RBL1	RBL1	RBL1	12988	-0.08	0.073	NO
299	ZNF641	ZNF641	ZNF641	13033	-0.081	0.073	NO
300	ZNF420	ZNF420	ZNF420	13176	-0.085	0.067	NO
301	UBE2D1	UBE2D1	UBE2D1	13180	-0.085	0.069	NO
302	ZNF619	ZNF619	ZNF619	13234	-0.086	0.068	NO
303	CCNT1	CCNT1	CCNT1	13289	-0.088	0.068	NO
304	USP9X	USP9X	USP9X	13476	-0.094	0.06	NO
305	CDK8	CDK8	CDK8	13489	-0.094	0.061	NO
306	MED30	MED30	MED30	13687	-0.1	0.053	NO
307	SKIL	SKIL	SKIL	13778	-0.1	0.05	NO
308	ZNF643	ZNF643	ZNF643	13797	-0.1	0.052	NO
309	ZNF430	ZNF430	ZNF430	13970	-0.11	0.045	NO
310	ZNF460	ZNF460	ZNF460	13973	-0.11	0.048	NO
311	ZNF426	ZNF426	ZNF426	14030	-0.11	0.048	NO
312	ESRRB	ESRRB	ESRRB	14353	-0.13	0.033	NO
313	PARP1	PARP1	PARP1	14643	-0.14	0.02	NO
314	JUNB	JUNB	JUNB	14810	-0.15	0.014	NO
315	NRBF2	NRBF2	NRBF2	14850	-0.15	0.016	NO
316	KAT2B	KAT2B	KAT2B	14855	-0.15	0.02	NO
317	NCOA2	NCOA2	NCOA2	14869	-0.15	0.023	NO
318	NR2E1	NR2E1	NR2E1	14887	-0.16	0.026	NO
319	NOTCH4	NOTCH4	NOTCH4	15138	-0.17	0.016	NO
320	CDKN2B	CDKN2B	CDKN2B	15374	-0.19	0.0078	NO
321	ZNF98	ZNF98	ZNF98	15532	-0.2	0.004	NO
322	NR4A2	NR4A2	NR4A2	15676	-0.21	0.0012	NO
323	NR4A1	NR4A1	NR4A1	15928	-0.23	-0.0072	NO
324	RXRA	RXRA	RXRA	16239	-0.25	-0.018	NO
325	NR0B2	NR0B2	NR0B2	16351	-0.26	-0.018	NO
326	NR0B1	NR0B1	NR0B1	16535	-0.28	-0.021	NO
327	NR5A2	NR5A2	NR5A2	16551	-0.28	-0.015	NO
328	ESR1	ESR1	ESR1	16741	-0.3	-0.018	NO
329	RXRG	RXRG	RXRG	16810	-0.3	-0.014	NO
330	VDR	VDR	VDR	16838	-0.31	-0.0074	NO
331	NR4A3	NR4A3	NR4A3	16961	-0.32	-0.006	NO
332	NR2F1	NR2F1	NR2F1	17272	-0.36	-0.014	NO
333	MYC	MYC	MYC	17337	-0.37	-0.0084	NO
334	SERPINE1	SERPINE1	SERPINE1	17424	-0.39	-0.0032	NO
335	NOTCH3	NOTCH3	NOTCH3	17552	-0.42	0.00028	NO
336	RORB	RORB	RORB	17708	-0.46	0.0033	NO
337	PGR	PGR	PGR	17730	-0.47	0.014	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	OR2A1	OR2A1	OR2A1	51	0.62	0.13	YES
2	OR2A25	OR2A25	OR2A25	1168	0.3	0.13	YES
3	OR10AD1	OR10AD1	OR10AD1	1301	0.28	0.18	YES
4	OR2A4	OR2A4	OR2A4	1379	0.27	0.23	YES
5	OR4F29	OR4F29	OR4F29	1382	0.27	0.29	YES
6	GNGT1	GNGT1	GNGT1	1426	0.27	0.34	YES
7	OR5K2	OR5K2	OR5K2	1589	0.25	0.39	YES
8	OR56B1	OR56B1	OR56B1	1959	0.22	0.41	YES
9	OR2T10	OR2T10	OR2T10	2660	0.17	0.41	YES
10	OR2AE1	OR2AE1	OR2AE1	2696	0.16	0.44	YES
11	OR52N4	OR52N4	OR52N4	2960	0.15	0.46	YES
12	OR2A7	OR2A7	OR2A7	3163	0.14	0.48	YES
13	GNAL	GNAL	GNAL	3321	0.13	0.5	YES
14	OR2T5	OR2T5	OR2T5	4330	0.093	0.46	NO
15	OR51B5	OR51B5	OR51B5	7667	0.016	0.28	NO
16	OR56B4	OR56B4	OR56B4	8757	-0.0016	0.22	NO
17	OR1J2	OR1J2	OR1J2	9360	-0.012	0.18	NO
18	OR1L8	OR1L8	OR1L8	9537	-0.015	0.18	NO
19	OR52N2	OR52N2	OR52N2	9922	-0.02	0.16	NO
20	GNB1	GNB1	GNB1	10087	-0.023	0.16	NO
21	OR4C6	OR4C6	OR4C6	10140	-0.024	0.16	NO
22	OR7D2	OR7D2	OR7D2	11481	-0.047	0.094	NO
23	OR2B11	OR2B11	OR2B11	11541	-0.049	0.1	NO
24	OR3A2	OR3A2	OR3A2	11908	-0.056	0.092	NO
25	OR2C1	OR2C1	OR2C1	13253	-0.087	0.035	NO
26	OR2B6	OR2B6	OR2B6	13714	-0.1	0.031	NO
27	OR2L13	OR2L13	OR2L13	14718	-0.14	0.0055	NO
28	OR2W3	OR2W3	OR2W3	14777	-0.15	0.033	NO
29	OR51E2	OR51E2	OR51E2	16061	-0.24	0.011	NO
30	OR51E1	OR51E1	OR51E1	17706	-0.46	0.015	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	GATA1	GATA1	GATA1	462	0.43	0.078	YES
2	SSPO	SSPO	SSPO	1800	0.23	0.059	YES
3	SMAD7	SMAD7	SMAD7	1971	0.22	0.1	YES
4	ZFPM1	ZFPM1	ZFPM1	2336	0.19	0.13	YES
5	HDAC9	HDAC9	HDAC9	2729	0.16	0.14	YES
6	NR2C1	NR2C1	NR2C1	3072	0.14	0.16	YES
7	HDAC11	HDAC11	HDAC11	3096	0.14	0.19	YES
8	GATA2	GATA2	GATA2	3884	0.11	0.17	YES
9	SIRT3	SIRT3	SIRT3	3934	0.11	0.2	YES
10	SIRT5	SIRT5	SIRT5	4805	0.079	0.17	YES
11	SIRT6	SIRT6	SIRT6	5031	0.073	0.17	YES
12	HDAC7	HDAC7	HDAC7	5192	0.069	0.18	YES
13	MBD2	MBD2	MBD2	5534	0.06	0.18	YES
14	NCOR1	NCOR1	NCOR1	5583	0.059	0.19	YES
15	SIRT7	SIRT7	SIRT7	5788	0.054	0.19	YES
16	XPO1	XPO1	XPO1	5896	0.052	0.2	YES
17	MBD3	MBD3	MBD3	6026	0.049	0.2	YES
18	FKBP3	FKBP3	FKBP3	6221	0.045	0.2	YES
19	HDAC1	HDAC1	HDAC1	6307	0.043	0.2	YES
20	SMURF1	SMURF1	SMURF1	6442	0.04	0.21	YES
21	SIN3B	SIN3B	SIN3B	6721	0.034	0.2	YES
22	HDAC6	HDAC6	HDAC6	6767	0.033	0.21	YES
23	PPARG	PPARG	PPARG	6890	0.031	0.21	YES
24	CHD3	CHD3	CHD3	6979	0.029	0.21	YES
25	HDAC4	HDAC4	HDAC4	6986	0.029	0.22	YES
26	SIRT4	SIRT4	SIRT4	7281	0.024	0.2	NO
27	TNFRSF1A	TNFRSF1A	TNFRSF1A	7539	0.019	0.2	NO
28	EP300	EP300	EP300	7861	0.013	0.18	NO
29	UBE2I	UBE2I	UBE2I	8038	0.0098	0.17	NO
30	RANGAP1	RANGAP1	RANGAP1	8197	0.0071	0.16	NO
31	CREBBP	CREBBP	CREBBP	8279	0.0058	0.16	NO
32	NFKB1	NFKB1	NFKB1	8382	0.0042	0.16	NO
33	SIN3A	SIN3A	SIN3A	8383	0.0042	0.16	NO
34	TNF	TNF	TNF	8396	0.004	0.16	NO
35	MTA2	MTA2	MTA2	8610	0.00073	0.15	NO
36	HDAC10	HDAC10	HDAC10	8647	0.00015	0.14	NO
37	TFCP2	TFCP2	TFCP2	8658	-0.000065	0.14	NO
38	RBBP4	RBBP4	RBBP4	9248	-0.0095	0.11	NO
39	SMG5	SMG5	SMG5	9577	-0.015	0.099	NO
40	HDAC8	HDAC8	HDAC8	9633	-0.016	0.1	NO
41	PRKACA	PRKACA	PRKACA	9635	-0.016	0.1	NO
42	GATAD2A	GATAD2A	GATAD2A	9720	-0.018	0.1	NO
43	SAP18	SAP18	SAP18	9759	-0.018	0.11	NO
44	RELA	RELA	RELA	9762	-0.018	0.11	NO
45	STAT3	STAT3	STAT3	9899	-0.02	0.11	NO
46	GATAD2B	GATAD2B	GATAD2B	10241	-0.026	0.094	NO
47	CHD4	CHD4	CHD4	10507	-0.03	0.087	NO
48	HDAC2	HDAC2	HDAC2	10888	-0.036	0.074	NO
49	NCOR2	NCOR2	NCOR2	10987	-0.038	0.078	NO
50	MAX	MAX	MAX	11049	-0.039	0.084	NO
51	NFKBIA	NFKBIA	NFKBIA	11598	-0.05	0.065	NO
52	SIRT1	SIRT1	SIRT1	11770	-0.054	0.068	NO
53	PRMT5	PRMT5	PRMT5	11919	-0.057	0.074	NO
54	HDAC5	HDAC5	HDAC5	12133	-0.061	0.076	NO
55	SUMO1	SUMO1	SUMO1	12203	-0.062	0.088	NO
56	RANBP2	RANBP2	RANBP2	12340	-0.065	0.096	NO
57	HDAC3	HDAC3	HDAC3	12594	-0.071	0.098	NO
58	YY1	YY1	YY1	12614	-0.071	0.11	NO
59	RBBP7	RBBP7	RBBP7	12688	-0.073	0.13	NO
60	SIRT2	SIRT2	SIRT2	12858	-0.077	0.14	NO
61	WDR77	WDR77	WDR77	13152	-0.084	0.14	NO
62	SAP30	SAP30	SAP30	13439	-0.092	0.15	NO
63	RAN	RAN	RAN	13898	-0.11	0.15	NO
64	KAT2B	KAT2B	KAT2B	14855	-0.15	0.13	NO
65	MXD1	MXD1	MXD1	15263	-0.18	0.15	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	ENO3	ENO3	ENO3	543	0.42	0.11	YES
2	PGAM2	PGAM2	PGAM2	669	0.39	0.24	YES
3	GAPDHS	GAPDHS	GAPDHS	1303	0.28	0.3	YES
4	PFKFB1	PFKFB1	PFKFB1	1449	0.27	0.38	YES
5	ENO2	ENO2	ENO2	7123	0.027	0.073	NO
6	ALDOC	ALDOC	ALDOC	7415	0.021	0.064	NO
7	PFKP	PFKP	PFKP	8125	0.0083	0.028	NO
8	PPP2R1A	PPP2R1A	PPP2R1A	9312	-0.011	-0.035	NO
9	ENO1	ENO1	ENO1	9748	-0.018	-0.053	NO
10	PKLR	PKLR	PKLR	9909	-0.02	-0.055	NO
11	GAPDH	GAPDH	GAPDH	10704	-0.033	-0.088	NO
12	PKM2	PKM2	PKM2	10979	-0.038	-0.09	NO
13	TPI1	TPI1	TPI1	11183	-0.041	-0.088	NO
14	PFKM	PFKM	PFKM	11380	-0.045	-0.083	NO
15	PPP2R5D	PPP2R5D	PPP2R5D	11529	-0.048	-0.075	NO
16	PPP2R1B	PPP2R1B	PPP2R1B	11547	-0.049	-0.059	NO
17	PPP2CA	PPP2CA	PPP2CA	11620	-0.05	-0.046	NO
18	PPP2CB	PPP2CB	PPP2CB	12001	-0.058	-0.048	NO
19	ALDOA	ALDOA	ALDOA	12185	-0.062	-0.037	NO
20	PGAM1	PGAM1	PGAM1	12700	-0.073	-0.04	NO
21	PFKL	PFKL	PFKL	12757	-0.074	-0.018	NO
22	PFKFB4	PFKFB4	PFKFB4	12910	-0.079	0.000028	NO
23	GPI	GPI	GPI	13343	-0.09	0.0065	NO
24	PGK1	PGK1	PGK1	13934	-0.11	0.011	NO
25	PFKFB2	PFKFB2	PFKFB2	14080	-0.12	0.042	NO
26	PFKFB3	PFKFB3	PFKFB3	14909	-0.16	0.05	NO
27	ALDOB	ALDOB	ALDOB	17254	-0.36	0.04	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	SPHK1	SPHK1	SPHK1	354	0.46	0.11	YES
2	TUBB1	TUBB1	TUBB1	902	0.35	0.18	YES
3	TUBB3	TUBB3	TUBB3	1153	0.31	0.25	YES
4	TUBB2B	TUBB2B	TUBB2B	4039	0.1	0.12	NO
5	TUBB6	TUBB6	TUBB6	4105	0.1	0.15	NO
6	FBXW4	FBXW4	FBXW4	4760	0.08	0.13	NO
7	FKBP9	FKBP9	FKBP9	5644	0.057	0.1	NO
8	FBXW7	FBXW7	FBXW7	5889	0.052	0.1	NO
9	KIFC3	KIFC3	KIFC3	6284	0.044	0.092	NO
10	PFDN6	PFDN6	PFDN6	6698	0.035	0.078	NO
11	USP11	USP11	USP11	7158	0.026	0.06	NO
12	TUBA1A	TUBA1A	TUBA1A	7498	0.02	0.047	NO
13	FBXO6	FBXO6	FBXO6	8140	0.0081	0.014	NO
14	FBXW2	FBXW2	FBXW2	8242	0.0063	0.0099	NO
15	TBCD	TBCD	TBCD	8276	0.0059	0.0097	NO
16	ACTB	ACTB	ACTB	8332	0.005	0.0081	NO
17	PFDN5	PFDN5	PFDN5	8360	0.0046	0.0079	NO
18	TBCB	TBCB	TBCB	8362	0.0045	0.0091	NO
19	FBXW5	FBXW5	FBXW5	8414	0.0036	0.0073	NO
20	TBCC	TBCC	TBCC	8982	-0.0052	-0.023	NO
21	FBXL3	FBXL3	FBXL3	9110	-0.0073	-0.028	NO
22	PFDN1	PFDN1	PFDN1	9487	-0.014	-0.045	NO
23	XRN2	XRN2	XRN2	9743	-0.018	-0.054	NO
24	NOP56	NOP56	NOP56	9871	-0.02	-0.056	NO
25	TUBA1C	TUBA1C	TUBA1C	9955	-0.021	-0.054	NO
26	TUBB2A	TUBB2A	TUBB2A	10025	-0.022	-0.052	NO
27	PFDN4	PFDN4	PFDN4	10191	-0.025	-0.054	NO
28	PFDN2	PFDN2	PFDN2	10293	-0.026	-0.052	NO
29	CCT6A	CCT6A	CCT6A	10398	-0.028	-0.05	NO
30	FBXL5	FBXL5	FBXL5	10830	-0.035	-0.064	NO
31	TUBA1B	TUBA1B	TUBA1B	10911	-0.037	-0.058	NO
32	ARFGEF2	ARFGEF2	ARFGEF2	10973	-0.038	-0.05	NO
33	FBXO4	FBXO4	FBXO4	11758	-0.053	-0.079	NO
34	TBCA	TBCA	TBCA	11798	-0.054	-0.066	NO
35	CCT2	CCT2	CCT2	12499	-0.068	-0.085	NO
36	AP3M1	AP3M1	AP3M1	12553	-0.07	-0.068	NO
37	CCT7	CCT7	CCT7	12689	-0.073	-0.055	NO
38	KIF13A	KIF13A	KIF13A	13056	-0.082	-0.052	NO
39	CCT3	CCT3	CCT3	13067	-0.082	-0.029	NO
40	CCT8	CCT8	CCT8	13166	-0.085	-0.01	NO
41	TCP1	TCP1	TCP1	13200	-0.086	0.012	NO
42	TUBA3D	TUBA3D	TUBA3D	13353	-0.09	0.029	NO
43	CCT5	CCT5	CCT5	13654	-0.1	0.041	NO
44	TBCE	TBCE	TBCE	13981	-0.11	0.055	NO
45	CCT4	CCT4	CCT4	14125	-0.12	0.08	NO
46	LONP2	LONP2	LONP2	14142	-0.12	0.11	NO
47	VBP1	VBP1	VBP1	14782	-0.15	0.12	NO
48	TUBA4A	TUBA4A	TUBA4A	15634	-0.21	0.13	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	NOG	NOG	NOG	276	0.48	0.099	YES
2	BMP4	BMP4	BMP4	512	0.42	0.18	YES
3	SMAD6	SMAD6	SMAD6	577	0.41	0.28	YES
4	NPPA	NPPA	NPPA	2066	0.21	0.24	YES
5	BMP7	BMP7	BMP7	2167	0.2	0.29	YES
6	FZD1	FZD1	FZD1	2301	0.19	0.32	YES
7	BMP2	BMP2	BMP2	2350	0.19	0.37	YES
8	HNF1A	HNF1A	HNF1A	2749	0.16	0.38	YES
9	WNT1	WNT1	WNT1	4853	0.078	0.28	NO
10	TGFB2	TGFB2	TGFB2	5416	0.063	0.27	NO
11	SMAD4	SMAD4	SMAD4	5430	0.062	0.28	NO
12	AXIN1	AXIN1	AXIN1	5623	0.058	0.28	NO
13	DVL1	DVL1	DVL1	5746	0.055	0.29	NO
14	TGFBR3	TGFBR3	TGFBR3	6573	0.037	0.25	NO
15	BMPR1A	BMPR1A	BMPR1A	7697	0.016	0.2	NO
16	SMAD5	SMAD5	SMAD5	7715	0.016	0.2	NO
17	TGFBR2	TGFBR2	TGFBR2	8821	-0.0028	0.14	NO
18	GSK3B	GSK3B	GSK3B	9148	-0.0079	0.12	NO
19	MAP3K7	MAP3K7	MAP3K7	9731	-0.018	0.092	NO
20	BMPR2	BMPR2	BMPR2	9866	-0.02	0.089	NO
21	SMAD1	SMAD1	SMAD1	10210	-0.025	0.076	NO
22	CTNNB1	CTNNB1	CTNNB1	10869	-0.036	0.048	NO
23	RFC1	RFC1	RFC1	10909	-0.037	0.054	NO
24	TGFB3	TGFB3	TGFB3	11982	-0.058	0.0085	NO
25	TGFBR1	TGFBR1	TGFBR1	12979	-0.08	-0.028	NO
26	APC	APC	APC	13399	-0.091	-0.03	NO
27	ACVR1	ACVR1	ACVR1	14459	-0.13	-0.057	NO
28	CHRD	CHRD	CHRD	14595	-0.14	-0.032	NO
29	TGFB1	TGFB1	TGFB1	14702	-0.14	-0.0036	NO
30	GATA4	GATA4	GATA4	14764	-0.15	0.028	NO
31	ATF2	ATF2	ATF2	15111	-0.17	0.049	NO
32	BMP5	BMP5	BMP5	15218	-0.18	0.085	NO
33	MEF2C	MEF2C	MEF2C	16694	-0.29	0.072	NO

Fold change

For the top enriched genes, if you want to check whether they are

up-regulated, please check the list of up-regulated genes
down-regulated, please check the list of down-regulated genes

Expression level

For the top enriched genes, if you want to check whether they are

highly expressed genes, please check the list of high (top 30%) expressed genes
low expressed genes, please check the list of low (bottom 30%) expressed genes

An expression pattern of top(30%)/middle(30%)/low(30%) in this subtype against other subtypes is available in a heatmap

Significant gene list

For the top enriched genes, if you want to check whether they are

significantly differently expressed genes by eBayes lm fit, please check the list of significant genes

+ Subtype clus3 enriched pathways

Table 5. Get Full Table This table shows top 10 pathways which are significantly enriched in cluster clus3. It displays only significant gene sets satisfying nom.p.val.threshold (-1), fwer.p.val.threshold (-1) , fdr.q.val.threshold (0.25) and the default table is sorted by Normalized Enrichment Score (NES). Further details on NES statistics, please visit The Broad GSEA website.

GeneSet(GS)	Size(#genes)	genes.ES.table	ES	NES	NOM.p.val	FDR.q.val	FWER.p.val	Tag..	Gene..	Signal	FDR..median.	glob.p.val
KEGG GLYCOLYSIS GLUCONEOGENESIS	58	genes.ES.table	0.57	1.8	0.0021	0.086	0.55	0.55	0.18	0.45	0.025	0.011
KEGG CITRATE CYCLE TCA CYCLE	29	genes.ES.table	0.81	2	0.002	0.033	0.17	0.9	0.17	0.75	0	0.004
KEGG PENTOSE PHOSPHATE PATHWAY	26	genes.ES.table	0.53	1.6	0.035	0.16	0.88	0.69	0.21	0.55	0.087	0.009
KEGG PENTOSE AND GLUCURONATE INTERCONVERSIONS	25	genes.ES.table	0.81	1.7	0	0.11	0.65	0.68	0.12	0.6	0.039	0.013
KEGG FRUCTOSE AND MANNOSE METABOLISM	33	genes.ES.table	0.54	1.6	0.026	0.16	0.87	0.27	0.096	0.25	0.083	0.011
KEGG FATTY ACID METABOLISM	39	genes.ES.table	0.73	2	0.0022	0.034	0.2	0.74	0.13	0.65	0	0.003
KEGG STEROID HORMONE BIOSYNTHESIS	49	genes.ES.table	0.69	1.7	0	0.12	0.74	0.41	0.065	0.38	0.054	0.01
KEGG OXIDATIVE PHOSPHORYLATION	112	genes.ES.table	0.57	1.6	0.08	0.15	0.81	0.75	0.22	0.59	0.071	0.013
KEGG PYRIMIDINE METABOLISM	97	genes.ES.table	0.36	1.5	0.071	0.22	0.93	0.42	0.27	0.31	0.14	0.014
KEGG ALANINE ASPARTATE AND GLUTAMATE METABOLISM	31	genes.ES.table	0.68	1.8	0.004	0.1	0.63	0.52	0.1	0.46	0.038	0.012

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	HAO2	HAO2	HAO2	4	0.88	0.083	YES
2	PIPOX	PIPOX	PIPOX	15	0.76	0.15	YES
3	DAO	DAO	DAO	19	0.74	0.22	YES
4	AGXT	AGXT	AGXT	80	0.54	0.27	YES
5	EHHADH	EHHADH	EHHADH	293	0.35	0.29	YES
6	SLC27A2	SLC27A2	SLC27A2	347	0.31	0.32	YES
7	MPV17L	MPV17L	MPV17L	355	0.31	0.35	YES
8	ACOX2	ACOX2	ACOX2	377	0.3	0.37	YES
9	PXMP2	PXMP2	PXMP2	420	0.28	0.4	YES
10	DHRS4	DHRS4	DHRS4	454	0.27	0.42	YES
11	EPHX2	EPHX2	EPHX2	641	0.22	0.43	YES
12	DDO	DDO	DDO	666	0.22	0.45	YES
13	ACSL1	ACSL1	ACSL1	712	0.21	0.47	YES
14	DECR2	DECR2	DECR2	713	0.21	0.49	YES
15	MLYCD	MLYCD	MLYCD	750	0.2	0.5	YES
16	FAR2	FAR2	FAR2	774	0.2	0.52	YES
17	PAOX	PAOX	PAOX	890	0.18	0.53	YES
18	HMGCL	HMGCL	HMGCL	999	0.17	0.54	YES
19	PHYH	PHYH	PHYH	1001	0.17	0.56	YES
20	ACAA1	ACAA1	ACAA1	1045	0.16	0.57	YES
21	IDH2	IDH2	IDH2	1141	0.15	0.58	YES
22	PEX11A	PEX11A	PEX11A	1206	0.14	0.59	YES
23	BAAT	BAAT	BAAT	1234	0.14	0.6	YES
24	HACL1	HACL1	HACL1	1260	0.14	0.61	YES
25	CAT	CAT	CAT	1270	0.14	0.62	YES
26	CRAT	CRAT	CRAT	1360	0.13	0.63	YES
27	SCP2	SCP2	SCP2	1495	0.12	0.64	YES
28	PEX3	PEX3	PEX3	1598	0.12	0.64	YES
29	PEX7	PEX7	PEX7	1606	0.12	0.65	YES
30	ECH1	ECH1	ECH1	1608	0.12	0.66	YES
31	PEX26	PEX26	PEX26	1618	0.12	0.67	YES
32	NUDT12	NUDT12	NUDT12	1774	0.11	0.68	YES
33	ABCD3	ABCD3	ABCD3	1801	0.1	0.68	YES
34	IDH1	IDH1	IDH1	1826	0.1	0.69	YES
35	MVK	MVK	MVK	1839	0.1	0.7	YES
36	PRDX1	PRDX1	PRDX1	1846	0.1	0.71	YES
37	SOD2	SOD2	SOD2	2038	0.096	0.71	YES
38	ACOX3	ACOX3	ACOX3	2055	0.095	0.72	YES
39	HSD17B4	HSD17B4	HSD17B4	2162	0.09	0.72	YES
40	ACOX1	ACOX1	ACOX1	2276	0.087	0.72	YES
41	PEX11G	PEX11G	PEX11G	2350	0.084	0.72	YES
42	SOD1	SOD1	SOD1	2681	0.074	0.71	NO
43	PEX5	PEX5	PEX5	2809	0.07	0.71	NO
44	NUDT19	NUDT19	NUDT19	2891	0.068	0.72	NO
45	PRDX5	PRDX5	PRDX5	3308	0.058	0.7	NO
46	PECR	PECR	PECR	3451	0.054	0.69	NO
47	GSTK1	GSTK1	GSTK1	3724	0.049	0.68	NO
48	ABCD4	ABCD4	ABCD4	3745	0.048	0.69	NO
49	MPV17	MPV17	MPV17	3756	0.048	0.69	NO
50	ACOT8	ACOT8	ACOT8	3870	0.046	0.69	NO
51	PEX10	PEX10	PEX10	4020	0.043	0.68	NO
52	PEX19	PEX19	PEX19	4111	0.041	0.68	NO
53	PMVK	PMVK	PMVK	4231	0.039	0.68	NO
54	PEX13	PEX13	PEX13	4245	0.039	0.68	NO
55	ABCD1	ABCD1	ABCD1	4633	0.032	0.66	NO
56	PEX11B	PEX11B	PEX11B	4937	0.027	0.65	NO
57	PEX16	PEX16	PEX16	5126	0.024	0.64	NO
58	AGPS	AGPS	AGPS	5130	0.024	0.64	NO
59	GNPAT	GNPAT	GNPAT	5729	0.016	0.61	NO
60	PEX14	PEX14	PEX14	6773	0.0022	0.56	NO
61	ABCD2	ABCD2	ABCD2	6991	-0.00078	0.54	NO
62	AMACR	AMACR	AMACR	7125	-0.0026	0.54	NO
63	PEX2	PEX2	PEX2	7787	-0.011	0.5	NO
64	ACSL3	ACSL3	ACSL3	7903	-0.013	0.49	NO
65	SLC25A17	SLC25A17	SLC25A17	8177	-0.016	0.48	NO
66	PEX6	PEX6	PEX6	8368	-0.019	0.47	NO
67	ACSL5	ACSL5	ACSL5	8820	-0.026	0.45	NO
68	PEX12	PEX12	PEX12	8848	-0.026	0.45	NO
69	PXMP4	PXMP4	PXMP4	8889	-0.027	0.45	NO
70	ACSL6	ACSL6	ACSL6	9233	-0.032	0.43	NO
71	PEX1	PEX1	PEX1	9601	-0.037	0.42	NO
72	XDH	XDH	XDH	11181	-0.065	0.34	NO
73	CROT	CROT	CROT	12849	-0.1	0.25	NO
74	ACSL4	ACSL4	ACSL4	13116	-0.11	0.25	NO
75	FAR1	FAR1	FAR1	13506	-0.12	0.24	NO
76	NOS2	NOS2	NOS2	14254	-0.14	0.21	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	PIPOX	PIPOX	PIPOX	15	0.76	0.14	YES
2	BBOX1	BBOX1	BBOX1	79	0.54	0.23	YES
3	ALDH1B1	ALDH1B1	ALDH1B1	238	0.38	0.29	YES
4	EHHADH	EHHADH	EHHADH	293	0.35	0.35	YES
5	ACAT1	ACAT1	ACAT1	619	0.23	0.38	YES
6	OGDHL	OGDHL	OGDHL	760	0.2	0.4	YES
7	ECHS1	ECHS1	ECHS1	865	0.18	0.43	YES
8	GCDH	GCDH	GCDH	932	0.18	0.46	YES
9	HADH	HADH	HADH	986	0.17	0.49	YES
10	AADAT	AADAT	AADAT	1019	0.16	0.52	YES
11	ACAT2	ACAT2	ACAT2	1085	0.16	0.54	YES
12	ALDH7A1	ALDH7A1	ALDH7A1	1108	0.16	0.57	YES
13	ALDH2	ALDH2	ALDH2	1187	0.15	0.59	YES
14	ALDH9A1	ALDH9A1	ALDH9A1	1229	0.14	0.62	YES
15	TMLHE	TMLHE	TMLHE	1444	0.13	0.63	YES
16	ALDH3A2	ALDH3A2	ALDH3A2	1903	0.1	0.62	YES
17	OGDH	OGDH	OGDH	2155	0.09	0.62	YES
18	PLOD1	PLOD1	PLOD1	2269	0.087	0.63	YES
19	DLST	DLST	DLST	2319	0.085	0.64	YES
20	HADHA	HADHA	HADHA	2343	0.085	0.66	YES
21	AASDHPPT	AASDHPPT	AASDHPPT	3837	0.046	0.58	NO
22	AASS	AASS	AASS	6086	0.011	0.46	NO
23	PLOD3	PLOD3	PLOD3	6205	0.0095	0.46	NO
24	SETDB2	SETDB2	SETDB2	6371	0.0074	0.45	NO
25	EHMT2	EHMT2	EHMT2	7914	-0.013	0.36	NO
26	NSD1	NSD1	NSD1	8168	-0.016	0.35	NO
27	SETDB1	SETDB1	SETDB1	8221	-0.017	0.35	NO
28	SETD7	SETD7	SETD7	8248	-0.018	0.36	NO
29	AASDH	AASDH	AASDH	8495	-0.021	0.35	NO
30	SUV39H2	SUV39H2	SUV39H2	8592	-0.022	0.34	NO
31	SETD1A	SETD1A	SETD1A	8880	-0.027	0.33	NO
32	SUV39H1	SUV39H1	SUV39H1	9259	-0.032	0.32	NO
33	SETD2	SETD2	SETD2	9861	-0.042	0.29	NO
34	ASH1L	ASH1L	ASH1L	10031	-0.045	0.29	NO
35	PLOD2	PLOD2	PLOD2	10271	-0.048	0.29	NO
36	EHMT1	EHMT1	EHMT1	11305	-0.067	0.24	NO
37	SUV420H1	SUV420H1	SUV420H1	11400	-0.069	0.25	NO
38	SETMAR	SETMAR	SETMAR	12108	-0.084	0.22	NO
39	WHSC1	WHSC1	WHSC1	12161	-0.085	0.24	NO
40	DOT1L	DOT1L	DOT1L	12230	-0.087	0.25	NO
41	SUV420H2	SUV420H2	SUV420H2	12238	-0.087	0.26	NO
42	WHSC1L1	WHSC1L1	WHSC1L1	12355	-0.09	0.28	NO
43	SETD8	SETD8	SETD8	12570	-0.094	0.28	NO
44	SETD1B	SETD1B	SETD1B	13493	-0.12	0.25	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	MARS2	MARS2	MARS2	1425	0.13	-0.017	YES
2	WARS2	WARS2	WARS2	1718	0.11	0.02	YES
3	EARS2	EARS2	EARS2	1767	0.11	0.07	YES
4	LARS2	LARS2	LARS2	1836	0.1	0.12	YES
5	DARS2	DARS2	DARS2	1923	0.1	0.16	YES
6	PARS2	PARS2	PARS2	1966	0.098	0.21	YES
7	FARS2	FARS2	FARS2	2062	0.095	0.25	YES
8	AARS	AARS	AARS	2444	0.081	0.27	YES
9	TARS2	TARS2	TARS2	2485	0.08	0.3	YES
10	NARS	NARS	NARS	2822	0.07	0.32	YES
11	YARS	YARS	YARS	2840	0.07	0.35	YES
12	IARS2	IARS2	IARS2	2905	0.067	0.38	YES
13	NARS2	NARS2	NARS2	2933	0.067	0.41	YES
14	SEPSECS	SEPSECS	SEPSECS	3029	0.064	0.44	YES
15	YARS2	YARS2	YARS2	3144	0.062	0.46	YES
16	IARS	IARS	IARS	3268	0.058	0.48	YES
17	HARS2	HARS2	HARS2	3681	0.05	0.49	YES
18	SARS	SARS	SARS	3961	0.044	0.49	YES
19	MTFMT	MTFMT	MTFMT	4126	0.041	0.5	YES
20	RARS	RARS	RARS	4131	0.041	0.52	YES
21	KARS	KARS	KARS	4167	0.04	0.54	YES
22	RARS2	RARS2	RARS2	4316	0.038	0.55	YES
23	TARS	TARS	TARS	4351	0.037	0.57	YES
24	VARS	VARS	VARS	4466	0.035	0.58	YES
25	FARSA	FARSA	FARSA	4724	0.03	0.58	YES
26	QARS	QARS	QARS	4819	0.029	0.59	YES
27	EPRS	EPRS	EPRS	4918	0.027	0.6	YES
28	GARS	GARS	GARS	4922	0.027	0.61	YES
29	FARSB	FARSB	FARSB	4938	0.027	0.62	YES
30	HARS	HARS	HARS	4941	0.027	0.63	YES
31	CARS2	CARS2	CARS2	4949	0.027	0.65	YES
32	WARS	WARS	WARS	5017	0.026	0.66	YES
33	VARS2	VARS2	VARS2	5021	0.026	0.67	YES
34	PSTK	PSTK	PSTK	5023	0.026	0.68	YES
35	SARS2	SARS2	SARS2	5135	0.024	0.69	YES
36	DARS	DARS	DARS	5519	0.019	0.67	NO
37	TARSL2	TARSL2	TARSL2	5577	0.018	0.68	NO
38	CARS	CARS	CARS	6081	0.011	0.66	NO
39	LARS	LARS	LARS	6466	0.0062	0.64	NO
40	AARS2	AARS2	AARS2	7069	-0.0018	0.6	NO
41	MARS	MARS	MARS	7362	-0.0056	0.59	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	TPD52L1	TPD52L1	TPD52L1	824	0.19	0.011	YES
2	FTL	FTL	FTL	832	0.19	0.067	YES
3	AP1M2	AP1M2	AP1M2	990	0.17	0.11	YES
4	SH3GL2	SH3GL2	SH3GL2	991	0.17	0.16	YES
5	DNAJC6	DNAJC6	DNAJC6	1152	0.15	0.19	YES
6	SH3D19	SH3D19	SH3D19	1843	0.1	0.19	YES
7	YIPF6	YIPF6	YIPF6	2076	0.094	0.2	YES
8	IGF2R	IGF2R	IGF2R	2090	0.093	0.23	YES
9	AP1S1	AP1S1	AP1S1	2310	0.086	0.24	YES
10	SNX5	SNX5	SNX5	2379	0.083	0.26	YES
11	HSPA8	HSPA8	HSPA8	2390	0.083	0.29	YES
12	SNX2	SNX2	SNX2	2410	0.082	0.31	YES
13	FTH1	FTH1	FTH1	2892	0.068	0.3	YES
14	SNX9	SNX9	SNX9	3077	0.063	0.31	YES
15	GAK	GAK	GAK	3112	0.062	0.33	YES
16	AP1M1	AP1M1	AP1M1	3123	0.062	0.35	YES
17	DTNBP1	DTNBP1	DTNBP1	3186	0.06	0.36	YES
18	PLDN	PLDN	PLDN	3252	0.059	0.38	YES
19	TGOLN2	TGOLN2	TGOLN2	3267	0.058	0.39	YES
20	CLTC	CLTC	CLTC	3355	0.056	0.4	YES
21	AP3S1	AP3S1	AP3S1	3373	0.056	0.42	YES
22	GNS	GNS	GNS	3476	0.054	0.43	YES
23	VAMP7	VAMP7	VAMP7	3522	0.053	0.44	YES
24	RAB5C	RAB5C	RAB5C	3631	0.051	0.45	YES
25	AP1G1	AP1G1	AP1G1	3718	0.049	0.46	YES
26	BLOC1S1	BLOC1S1	BLOC1S1	3964	0.044	0.46	YES
27	STX4	STX4	STX4	3973	0.043	0.47	YES
28	AP1B1	AP1B1	AP1B1	4012	0.043	0.48	YES
29	VAMP8	VAMP8	VAMP8	4017	0.043	0.5	YES
30	DNASE2	DNASE2	DNASE2	4142	0.041	0.5	YES
31	NAPA	NAPA	NAPA	4246	0.039	0.51	YES
32	SNAP23	SNAP23	SNAP23	4321	0.038	0.52	YES
33	AP3B1	AP3B1	AP3B1	4496	0.034	0.52	YES
34	CLTA	CLTA	CLTA	4596	0.032	0.52	YES
35	TBC1D8B	TBC1D8B	TBC1D8B	4701	0.031	0.52	YES
36	NECAP1	NECAP1	NECAP1	4862	0.028	0.52	NO
37	PICALM	PICALM	PICALM	6078	0.011	0.46	NO
38	M6PR	M6PR	M6PR	6412	0.0069	0.44	NO
39	CNO	CNO	CNO	6656	0.0037	0.43	NO
40	PUM1	PUM1	PUM1	6745	0.0026	0.42	NO
41	ARRB1	ARRB1	ARRB1	6787	0.0019	0.42	NO
42	CTSZ	CTSZ	CTSZ	7208	-0.0038	0.4	NO
43	AP1S2	AP1S2	AP1S2	7295	-0.0046	0.4	NO
44	ARF1	ARF1	ARF1	7755	-0.011	0.38	NO
45	SNAPIN	SNAPIN	SNAPIN	8001	-0.014	0.36	NO
46	AP4E1	AP4E1	AP4E1	8057	-0.015	0.37	NO
47	TPD52	TPD52	TPD52	8614	-0.023	0.34	NO
48	SORT1	SORT1	SORT1	8672	-0.024	0.35	NO
49	OCRL	OCRL	OCRL	8765	-0.025	0.35	NO
50	GBF1	GBF1	GBF1	8768	-0.025	0.36	NO
51	BLOC1S3	BLOC1S3	BLOC1S3	9053	-0.029	0.35	NO
52	TXNDC5	TXNDC5	TXNDC5	9108	-0.03	0.35	NO
53	PIK3C2A	PIK3C2A	PIK3C2A	9743	-0.04	0.33	NO
54	VAMP2	VAMP2	VAMP2	10231	-0.048	0.32	NO
55	CPD	CPD	CPD	10288	-0.049	0.33	NO
56	DNM2	DNM2	DNM2	10792	-0.057	0.32	NO
57	AP4B1	AP4B1	AP4B1	10822	-0.058	0.33	NO
58	HIP1R	HIP1R	HIP1R	12115	-0.084	0.29	NO
59	TFRC	TFRC	TFRC	14043	-0.14	0.22	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	MARS2	MARS2	MARS2	1425	0.13	-0.021	YES
2	WARS2	WARS2	WARS2	1718	0.11	0.012	YES
3	PPA2	PPA2	PPA2	1742	0.11	0.06	YES
4	EARS2	EARS2	EARS2	1767	0.11	0.11	YES
5	LARS2	LARS2	LARS2	1836	0.1	0.15	YES
6	DARS2	DARS2	DARS2	1923	0.1	0.19	YES
7	PARS2	PARS2	PARS2	1966	0.098	0.23	YES
8	FARS2	FARS2	FARS2	2062	0.095	0.27	YES
9	AIMP2	AIMP2	AIMP2	2067	0.095	0.32	YES
10	PPA1	PPA1	PPA1	2180	0.09	0.35	YES
11	AARS	AARS	AARS	2444	0.081	0.37	YES
12	TARS2	TARS2	TARS2	2485	0.08	0.41	YES
13	NARS	NARS	NARS	2822	0.07	0.42	YES
14	YARS	YARS	YARS	2840	0.07	0.45	YES
15	IARS2	IARS2	IARS2	2905	0.067	0.48	YES
16	NARS2	NARS2	NARS2	2933	0.067	0.51	YES
17	YARS2	YARS2	YARS2	3144	0.062	0.52	YES
18	IARS	IARS	IARS	3268	0.058	0.54	YES
19	HARS2	HARS2	HARS2	3681	0.05	0.54	YES
20	SARS	SARS	SARS	3961	0.044	0.55	YES
21	RARS	RARS	RARS	4131	0.041	0.56	YES
22	KARS	KARS	KARS	4167	0.04	0.57	YES
23	RARS2	RARS2	RARS2	4316	0.038	0.58	YES
24	TARS	TARS	TARS	4351	0.037	0.6	YES
25	VARS	VARS	VARS	4466	0.035	0.6	YES
26	FARSA	FARSA	FARSA	4724	0.03	0.6	YES
27	QARS	QARS	QARS	4819	0.029	0.61	YES
28	EPRS	EPRS	EPRS	4918	0.027	0.62	YES
29	GARS	GARS	GARS	4922	0.027	0.63	YES
30	FARSB	FARSB	FARSB	4938	0.027	0.64	YES
31	HARS	HARS	HARS	4941	0.027	0.66	YES
32	CARS2	CARS2	CARS2	4949	0.027	0.67	YES
33	WARS	WARS	WARS	5017	0.026	0.68	YES
34	VARS2	VARS2	VARS2	5021	0.026	0.69	YES
35	SARS2	SARS2	SARS2	5135	0.024	0.69	YES
36	DARS	DARS	DARS	5519	0.019	0.68	NO
37	CARS	CARS	CARS	6081	0.011	0.65	NO
38	LARS	LARS	LARS	6466	0.0062	0.63	NO
39	AIMP1	AIMP1	AIMP1	6551	0.0051	0.63	NO
40	AARS2	AARS2	AARS2	7069	-0.0018	0.6	NO
41	EEF1E1	EEF1E1	EEF1E1	7337	-0.0052	0.59	NO
42	MARS	MARS	MARS	7362	-0.0056	0.59	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	PKLR	PKLR	PKLR	9	0.8	0.13	YES
2	PCK1	PCK1	PCK1	56	0.6	0.22	YES
3	ALDH1B1	ALDH1B1	ALDH1B1	238	0.38	0.27	YES
4	LDHD	LDHD	LDHD	242	0.37	0.33	YES
5	PC	PC	PC	263	0.36	0.39	YES
6	ME1	ME1	ME1	333	0.32	0.44	YES
7	ACOT12	ACOT12	ACOT12	444	0.27	0.47	YES
8	PCK2	PCK2	PCK2	465	0.26	0.51	YES
9	ACAT1	ACAT1	ACAT1	619	0.23	0.54	YES
10	GRHPR	GRHPR	GRHPR	814	0.19	0.56	YES
11	LDHC	LDHC	LDHC	857	0.19	0.59	YES
12	HAGH	HAGH	HAGH	945	0.17	0.61	YES
13	ACAT2	ACAT2	ACAT2	1085	0.16	0.63	YES
14	HAGHL	HAGHL	HAGHL	1106	0.16	0.65	YES
15	ALDH7A1	ALDH7A1	ALDH7A1	1108	0.16	0.68	YES
16	ALDH2	ALDH2	ALDH2	1187	0.15	0.7	YES
17	ALDH9A1	ALDH9A1	ALDH9A1	1229	0.14	0.72	YES
18	MDH1	MDH1	MDH1	1265	0.14	0.74	YES
19	ALDH3A2	ALDH3A2	ALDH3A2	1903	0.1	0.72	YES
20	ACSS2	ACSS2	ACSS2	1945	0.099	0.73	YES
21	ACSS1	ACSS1	ACSS1	1956	0.099	0.75	YES
22	DLAT	DLAT	DLAT	2191	0.089	0.75	YES
23	LDHB	LDHB	LDHB	2216	0.088	0.76	YES
24	PDHA1	PDHA1	PDHA1	2599	0.077	0.75	YES
25	MDH2	MDH2	MDH2	2641	0.075	0.76	YES
26	DLD	DLD	DLD	2877	0.068	0.76	YES
27	PDHB	PDHB	PDHB	2914	0.067	0.77	YES
28	ME2	ME2	ME2	4399	0.036	0.69	NO
29	ME3	ME3	ME3	4579	0.033	0.69	NO
30	ACACB	ACACB	ACACB	6020	0.012	0.61	NO
31	AKR1B1	AKR1B1	AKR1B1	6576	0.0048	0.58	NO
32	PKM2	PKM2	PKM2	6874	0.00084	0.56	NO
33	LDHA	LDHA	LDHA	7973	-0.014	0.5	NO
34	ACYP2	ACYP2	ACYP2	8159	-0.016	0.5	NO
35	ACACA	ACACA	ACACA	8332	-0.019	0.49	NO
36	GLO1	GLO1	GLO1	8936	-0.027	0.46	NO
37	LDHAL6B	LDHAL6B	LDHAL6B	11228	-0.066	0.34	NO
38	ACYP1	ACYP1	ACYP1	11262	-0.066	0.35	NO
39	LDHAL6A	LDHAL6A	LDHAL6A	14291	-0.15	0.21	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	AOX1	AOX1	AOX1	135	0.47	0.056	YES
2	ABAT	ABAT	ABAT	155	0.45	0.12	YES
3	ALDH6A1	ALDH6A1	ALDH6A1	161	0.44	0.18	YES
4	ALDH1B1	ALDH1B1	ALDH1B1	238	0.38	0.22	YES
5	EHHADH	EHHADH	EHHADH	293	0.35	0.27	YES
6	ACAT1	ACAT1	ACAT1	619	0.23	0.28	YES
7	PCCA	PCCA	PCCA	664	0.22	0.31	YES
8	OXCT1	OXCT1	OXCT1	773	0.2	0.33	YES
9	HIBCH	HIBCH	HIBCH	836	0.19	0.35	YES
10	ACADM	ACADM	ACADM	837	0.19	0.38	YES
11	ACADS	ACADS	ACADS	846	0.19	0.4	YES
12	ECHS1	ECHS1	ECHS1	865	0.18	0.43	YES
13	HMGCS2	HMGCS2	HMGCS2	915	0.18	0.45	YES
14	MCCC1	MCCC1	MCCC1	930	0.18	0.47	YES
15	HADH	HADH	HADH	986	0.17	0.49	YES
16	HMGCL	HMGCL	HMGCL	999	0.17	0.52	YES
17	ACAA1	ACAA1	ACAA1	1045	0.16	0.53	YES
18	ACAA2	ACAA2	ACAA2	1048	0.16	0.56	YES
19	AUH	AUH	AUH	1060	0.16	0.58	YES
20	BCAT2	BCAT2	BCAT2	1066	0.16	0.6	YES
21	ACAT2	ACAT2	ACAT2	1085	0.16	0.62	YES
22	ALDH7A1	ALDH7A1	ALDH7A1	1108	0.16	0.64	YES
23	ACADSB	ACADSB	ACADSB	1111	0.16	0.66	YES
24	PCCB	PCCB	PCCB	1143	0.15	0.68	YES
25	ALDH2	ALDH2	ALDH2	1187	0.15	0.7	YES
26	ALDH9A1	ALDH9A1	ALDH9A1	1229	0.14	0.72	YES
27	MUT	MUT	MUT	1277	0.14	0.73	YES
28	MCCC2	MCCC2	MCCC2	1460	0.12	0.74	YES
29	MCEE	MCEE	MCEE	1487	0.12	0.75	YES
30	IL4I1	IL4I1	IL4I1	1663	0.11	0.76	YES
31	HIBADH	HIBADH	HIBADH	1724	0.11	0.77	YES
32	BCAT1	BCAT1	BCAT1	1772	0.11	0.78	YES
33	IVD	IVD	IVD	1787	0.11	0.8	YES
34	ACAD8	ACAD8	ACAD8	1854	0.1	0.81	YES
35	ALDH3A2	ALDH3A2	ALDH3A2	1903	0.1	0.82	YES
36	DBT	DBT	DBT	1918	0.1	0.83	YES
37	HADHB	HADHB	HADHB	2339	0.085	0.82	YES
38	HADHA	HADHA	HADHA	2343	0.085	0.83	YES
39	BCKDHA	BCKDHA	BCKDHA	2462	0.081	0.83	YES
40	DLD	DLD	DLD	2877	0.068	0.82	NO
41	BCKDHB	BCKDHB	BCKDHB	2959	0.066	0.82	NO
42	HSD17B10	HSD17B10	HSD17B10	3187	0.06	0.82	NO
43	OXCT2	OXCT2	OXCT2	5028	0.026	0.72	NO
44	HMGCS1	HMGCS1	HMGCS1	6712	0.0031	0.63	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	TPD52L1	TPD52L1	TPD52L1	824	0.19	0.014	YES
2	FTL	FTL	FTL	832	0.19	0.074	YES
3	AP1M2	AP1M2	AP1M2	990	0.17	0.12	YES
4	SH3GL2	SH3GL2	SH3GL2	991	0.17	0.17	YES
5	DNAJC6	DNAJC6	DNAJC6	1152	0.15	0.21	YES
6	SH3D19	SH3D19	SH3D19	1843	0.1	0.21	YES
7	YIPF6	YIPF6	YIPF6	2076	0.094	0.22	YES
8	IGF2R	IGF2R	IGF2R	2090	0.093	0.25	YES
9	AP1S1	AP1S1	AP1S1	2310	0.086	0.27	YES
10	SNX5	SNX5	SNX5	2379	0.083	0.29	YES
11	HSPA8	HSPA8	HSPA8	2390	0.083	0.32	YES
12	SNX2	SNX2	SNX2	2410	0.082	0.34	YES
13	FTH1	FTH1	FTH1	2892	0.068	0.34	YES
14	SNX9	SNX9	SNX9	3077	0.063	0.34	YES
15	GAK	GAK	GAK	3112	0.062	0.36	YES
16	AP1M1	AP1M1	AP1M1	3123	0.062	0.38	YES
17	DTNBP1	DTNBP1	DTNBP1	3186	0.06	0.4	YES
18	PLDN	PLDN	PLDN	3252	0.059	0.41	YES
19	TGOLN2	TGOLN2	TGOLN2	3267	0.058	0.43	YES
20	CLTC	CLTC	CLTC	3355	0.056	0.44	YES
21	AP3S1	AP3S1	AP3S1	3373	0.056	0.46	YES
22	VAMP7	VAMP7	VAMP7	3522	0.053	0.47	YES
23	RAB5C	RAB5C	RAB5C	3631	0.051	0.48	YES
24	AP1G1	AP1G1	AP1G1	3718	0.049	0.49	YES
25	BLOC1S1	BLOC1S1	BLOC1S1	3964	0.044	0.49	YES
26	AP1B1	AP1B1	AP1B1	4012	0.043	0.5	YES
27	VAMP8	VAMP8	VAMP8	4017	0.043	0.51	YES
28	NAPA	NAPA	NAPA	4246	0.039	0.51	YES
29	AP3B1	AP3B1	AP3B1	4496	0.034	0.51	YES
30	CLTA	CLTA	CLTA	4596	0.032	0.52	YES
31	TBC1D8B	TBC1D8B	TBC1D8B	4701	0.031	0.52	YES
32	NECAP1	NECAP1	NECAP1	4862	0.028	0.52	NO
33	PICALM	PICALM	PICALM	6078	0.011	0.46	NO
34	CNO	CNO	CNO	6656	0.0037	0.42	NO
35	PUM1	PUM1	PUM1	6745	0.0026	0.42	NO
36	ARRB1	ARRB1	ARRB1	6787	0.0019	0.42	NO
37	AP1S2	AP1S2	AP1S2	7295	-0.0046	0.39	NO
38	ARF1	ARF1	ARF1	7755	-0.011	0.37	NO
39	SNAPIN	SNAPIN	SNAPIN	8001	-0.014	0.36	NO
40	AP4E1	AP4E1	AP4E1	8057	-0.015	0.36	NO
41	TPD52	TPD52	TPD52	8614	-0.023	0.34	NO
42	SORT1	SORT1	SORT1	8672	-0.024	0.34	NO
43	OCRL	OCRL	OCRL	8765	-0.025	0.34	NO
44	BLOC1S3	BLOC1S3	BLOC1S3	9053	-0.029	0.34	NO
45	TXNDC5	TXNDC5	TXNDC5	9108	-0.03	0.34	NO
46	PIK3C2A	PIK3C2A	PIK3C2A	9743	-0.04	0.32	NO
47	VAMP2	VAMP2	VAMP2	10231	-0.048	0.31	NO
48	CPD	CPD	CPD	10288	-0.049	0.32	NO
49	DNM2	DNM2	DNM2	10792	-0.057	0.31	NO
50	AP4B1	AP4B1	AP4B1	10822	-0.058	0.33	NO
51	HIP1R	HIP1R	HIP1R	12115	-0.084	0.28	NO
52	TFRC	TFRC	TFRC	14043	-0.14	0.22	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	QPRT	QPRT	QPRT	66	0.57	0.11	YES
2	ENPP1	ENPP1	ENPP1	97	0.52	0.21	YES
3	SLC23A1	SLC23A1	SLC23A1	337	0.32	0.26	YES
4	ACP5	ACP5	ACP5	359	0.31	0.32	YES
5	PANK1	PANK1	PANK1	451	0.27	0.37	YES
6	SLC19A3	SLC19A3	SLC19A3	663	0.22	0.4	YES
7	CYB5A	CYB5A	CYB5A	901	0.18	0.42	YES
8	MTHFD1	MTHFD1	MTHFD1	1010	0.17	0.45	YES
9	SHMT1	SHMT1	SHMT1	1107	0.16	0.47	YES
10	PNPO	PNPO	PNPO	1310	0.14	0.49	YES
11	MTHFR	MTHFR	MTHFR	1352	0.13	0.51	YES
12	GPHN	GPHN	GPHN	1463	0.12	0.53	YES
13	PANK3	PANK3	PANK3	1838	0.1	0.53	YES
14	PPCS	PPCS	PPCS	1938	0.099	0.54	YES
15	GSTO1	GSTO1	GSTO1	2243	0.088	0.54	YES
16	RFK	RFK	RFK	2512	0.079	0.54	YES
17	NMNAT1	NMNAT1	NMNAT1	2626	0.076	0.55	YES
18	NFS1	NFS1	NFS1	2638	0.075	0.57	YES
19	DHFR	DHFR	DHFR	2703	0.074	0.58	YES
20	SLC46A1	SLC46A1	SLC46A1	2770	0.072	0.59	YES
21	MOCS2	MOCS2	MOCS2	2991	0.065	0.59	YES
22	MOCS3	MOCS3	MOCS3	3040	0.064	0.6	YES
23	THTPA	THTPA	THTPA	3168	0.061	0.6	YES
24	SLC25A16	SLC25A16	SLC25A16	3315	0.058	0.61	YES
25	AASDHPPT	AASDHPPT	AASDHPPT	3837	0.046	0.59	NO
26	FLAD1	FLAD1	FLAD1	3948	0.044	0.59	NO
27	COASY	COASY	COASY	4081	0.042	0.59	NO
28	MOCS1	MOCS1	MOCS1	4505	0.034	0.57	NO
29	FPGS	FPGS	FPGS	4769	0.03	0.56	NO
30	NADK	NADK	NADK	4886	0.028	0.56	NO
31	NMNAT3	NMNAT3	NMNAT3	5447	0.02	0.54	NO
32	FASN	FASN	FASN	5454	0.02	0.54	NO
33	SLC25A32	SLC25A32	SLC25A32	5844	0.014	0.52	NO
34	TPK1	TPK1	TPK1	5969	0.012	0.52	NO
35	SLC19A1	SLC19A1	SLC19A1	6142	0.01	0.51	NO
36	PANK2	PANK2	PANK2	6549	0.0051	0.49	NO
37	MOCOS	MOCOS	MOCOS	6744	0.0026	0.48	NO
38	PPCDC	PPCDC	PPCDC	7496	-0.0073	0.44	NO
39	PDXK	PDXK	PDXK	7749	-0.011	0.42	NO
40	SLC19A2	SLC19A2	SLC19A2	8002	-0.014	0.41	NO
41	PANK4	PANK4	PANK4	8436	-0.02	0.39	NO
42	SLC5A6	SLC5A6	SLC5A6	8547	-0.022	0.39	NO
43	NADSYN1	NADSYN1	NADSYN1	8551	-0.022	0.4	NO
44	CYB5R3	CYB5R3	CYB5R3	8729	-0.024	0.39	NO
45	GSTO2	GSTO2	GSTO2	8794	-0.025	0.39	NO
46	NAMPT	NAMPT	NAMPT	10563	-0.053	0.3	NO
47	SLC2A1	SLC2A1	SLC2A1	10855	-0.058	0.3	NO
48	SLC23A2	SLC23A2	SLC23A2	12709	-0.098	0.22	NO
49	NMNAT2	NMNAT2	NMNAT2	15415	-0.19	0.1	NO
50	SLC2A3	SLC2A3	SLC2A3	15689	-0.21	0.13	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	PCK1	PCK1	PCK1	56	0.6	0.15	YES
2	PC	PC	PC	263	0.36	0.24	YES
3	PCK2	PCK2	PCK2	465	0.26	0.29	YES
4	OGDHL	OGDHL	OGDHL	760	0.2	0.33	YES
5	ACO1	ACO1	ACO1	1088	0.16	0.35	YES
6	SUCLG2	SUCLG2	SUCLG2	1118	0.16	0.39	YES
7	IDH2	IDH2	IDH2	1141	0.15	0.43	YES
8	SDHB	SDHB	SDHB	1174	0.15	0.47	YES
9	ACO2	ACO2	ACO2	1251	0.14	0.5	YES
10	MDH1	MDH1	MDH1	1265	0.14	0.53	YES
11	SUCLG1	SUCLG1	SUCLG1	1420	0.13	0.56	YES
12	SDHD	SDHD	SDHD	1587	0.12	0.58	YES
13	SDHA	SDHA	SDHA	1653	0.11	0.61	YES
14	IDH1	IDH1	IDH1	1826	0.1	0.62	YES
15	FH	FH	FH	1922	0.1	0.64	YES
16	SDHC	SDHC	SDHC	1924	0.1	0.67	YES
17	OGDH	OGDH	OGDH	2155	0.09	0.68	YES
18	SUCLA2	SUCLA2	SUCLA2	2167	0.09	0.7	YES
19	DLAT	DLAT	DLAT	2191	0.089	0.72	YES
20	DLST	DLST	DLST	2319	0.085	0.74	YES
21	PDHA1	PDHA1	PDHA1	2599	0.077	0.74	YES
22	MDH2	MDH2	MDH2	2641	0.075	0.76	YES
23	IDH3B	IDH3B	IDH3B	2670	0.074	0.78	YES
24	DLD	DLD	DLD	2877	0.068	0.79	YES
25	PDHB	PDHB	PDHB	2914	0.067	0.8	YES
26	IDH3G	IDH3G	IDH3G	2997	0.065	0.81	YES
27	CS	CS	CS	3647	0.05	0.79	NO
28	ACLY	ACLY	ACLY	5702	0.016	0.68	NO
29	IDH3A	IDH3A	IDH3A	5710	0.016	0.68	NO

Fold change

For the top enriched genes, if you want to check whether they are

up-regulated, please check the list of up-regulated genes
down-regulated, please check the list of down-regulated genes

Expression level

For the top enriched genes, if you want to check whether they are

highly expressed genes, please check the list of high (top 30%) expressed genes
low expressed genes, please check the list of low (bottom 30%) expressed genes

An expression pattern of top(30%)/middle(30%)/low(30%) in this subtype against other subtypes is available in a heatmap

Significant gene list

For the top enriched genes, if you want to check whether they are

significantly differently expressed genes by eBayes lm fit, please check the list of significant genes

+ Subtype clus4 enriched pathways

Table 6. Get Full Table This table shows top 10 pathways which are significantly enriched in cluster clus4. It displays only significant gene sets satisfying nom.p.val.threshold (-1), fwer.p.val.threshold (-1) , fdr.q.val.threshold (0.25) and the default table is sorted by Normalized Enrichment Score (NES). Further details on NES statistics, please visit The Broad GSEA website.

GeneSet(GS)	Size(#genes)	genes.ES.table	ES	NES	NOM.p.val	FDR.q.val	FWER.p.val	Tag..	Gene..	Signal	FDR..median.	glob.p.val
KEGG N GLYCAN BIOSYNTHESIS	46	genes.ES.table	0.43	1.5	0.09	0.14	0.96	0.22	0.23	0.17	0.095	0.001
KEGG O GLYCAN BIOSYNTHESIS	29	genes.ES.table	0.47	1.3	0.11	0.23	0.99	0.31	0.15	0.26	0.19	0
KEGG GLYCOSAMINOGLYCAN BIOSYNTHESIS HEPARAN SULFATE	25	genes.ES.table	0.49	1.3	0.16	0.23	0.99	0.56	0.34	0.37	0.19	0
KEGG GLYCOSPHINGOLIPID BIOSYNTHESIS LACTO AND NEOLACTO SERIES	26	genes.ES.table	0.51	1.4	0.093	0.2	0.99	0.27	0.13	0.24	0.16	0
KEGG BASAL TRANSCRIPTION FACTORS	34	genes.ES.table	0.42	1.3	0.22	0.23	1	0.38	0.3	0.27	0.2	0
KEGG MAPK SIGNALING PATHWAY	243	genes.ES.table	0.45	1.6	0.002	0.13	0.83	0.28	0.18	0.23	0.066	0.007
KEGG ERBB SIGNALING PATHWAY	87	genes.ES.table	0.41	1.6	0.008	0.13	0.93	0.39	0.33	0.26	0.08	0.002
KEGG CALCIUM SIGNALING PATHWAY	166	genes.ES.table	0.57	1.6	0	0.13	0.87	0.37	0.16	0.31	0.073	0.004
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION	231	genes.ES.table	0.61	1.5	0.042	0.14	0.96	0.58	0.21	0.46	0.092	0.001
KEGG CHEMOKINE SIGNALING PATHWAY	183	genes.ES.table	0.55	1.5	0.093	0.16	0.98	0.43	0.22	0.34	0.11	0.001

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	CNTN1	CNTN1	CNTN1	4	0.83	0.099	YES
2	HEYL	HEYL	HEYL	520	0.46	0.12	YES
3	DLL1	DLL1	DLL1	662	0.42	0.17	YES
4	DLL4	DLL4	DLL4	1061	0.36	0.19	YES
5	MAML2	MAML2	MAML2	1207	0.34	0.22	YES
6	HEY1	HEY1	HEY1	1274	0.33	0.26	YES
7	HEY2	HEY2	HEY2	1646	0.29	0.27	YES
8	MAML3	MAML3	MAML3	1668	0.29	0.3	YES
9	DTX1	DTX1	DTX1	1965	0.26	0.32	YES
10	NEURL	NEURL	NEURL	2025	0.26	0.35	YES
11	ADAM10	ADAM10	ADAM10	2955	0.19	0.32	YES
12	HES1	HES1	HES1	3094	0.18	0.33	YES
13	ADAM17	ADAM17	ADAM17	3469	0.16	0.33	YES
14	JAG2	JAG2	JAG2	3546	0.16	0.34	YES
15	JAG1	JAG1	JAG1	3575	0.16	0.36	YES
16	HES5	HES5	HES5	3705	0.15	0.37	YES
17	MIB1	MIB1	MIB1	3756	0.15	0.39	YES
18	MAMLD1	MAMLD1	MAMLD1	3792	0.15	0.4	YES
19	HDAC4	HDAC4	HDAC4	3905	0.14	0.42	YES
20	ARRB1	ARRB1	ARRB1	3948	0.14	0.43	YES
21	TLE2	TLE2	TLE2	3990	0.14	0.44	YES
22	EP300	EP300	EP300	4158	0.14	0.45	YES
23	TLE3	TLE3	TLE3	4284	0.13	0.46	YES
24	FBXW7	FBXW7	FBXW7	4296	0.13	0.48	YES
25	HIF1A	HIF1A	HIF1A	4370	0.13	0.49	YES
26	HDAC1	HDAC1	HDAC1	4871	0.11	0.47	YES
27	MAML1	MAML1	MAML1	4880	0.11	0.48	YES
28	KAT2B	KAT2B	KAT2B	4885	0.11	0.5	YES
29	HDAC9	HDAC9	HDAC9	5126	0.1	0.5	YES
30	APH1B	APH1B	APH1B	5214	0.099	0.5	YES
31	NCOR2	NCOR2	NCOR2	5278	0.097	0.51	YES
32	DTX4	DTX4	DTX4	5516	0.09	0.51	NO
33	TLE4	TLE4	TLE4	5713	0.085	0.51	NO
34	HDAC2	HDAC2	HDAC2	5907	0.081	0.51	NO
35	NCOR1	NCOR1	NCOR1	6379	0.071	0.49	NO
36	CDK8	CDK8	CDK8	6649	0.065	0.48	NO
37	NCSTN	NCSTN	NCSTN	7098	0.056	0.46	NO
38	HDAC7	HDAC7	HDAC7	7254	0.053	0.46	NO
39	SNW1	SNW1	SNW1	7431	0.05	0.46	NO
40	RBPJ	RBPJ	RBPJ	7466	0.049	0.46	NO
41	CREBBP	CREBBP	CREBBP	7530	0.048	0.46	NO
42	TBL1X	TBL1X	TBL1X	7532	0.048	0.47	NO
43	TBL1XR1	TBL1XR1	TBL1XR1	7694	0.045	0.47	NO
44	CUL1	CUL1	CUL1	8271	0.036	0.44	NO
45	TLE1	TLE1	TLE1	8607	0.03	0.42	NO
46	CCNC	CCNC	CCNC	8687	0.029	0.42	NO
47	MYC	MYC	MYC	8752	0.028	0.42	NO
48	PSEN1	PSEN1	PSEN1	8850	0.026	0.42	NO
49	DTX2	DTX2	DTX2	8957	0.025	0.42	NO
50	APH1A	APH1A	APH1A	9856	0.01	0.37	NO
51	DNER	DNER	DNER	10115	0.006	0.35	NO
52	RPS27A	RPS27A	RPS27A	10303	0.0027	0.34	NO
53	SKP1	SKP1	SKP1	10565	-0.0014	0.33	NO
54	RBX1	RBX1	RBX1	10746	-0.0046	0.32	NO
55	HDAC3	HDAC3	HDAC3	11055	-0.0098	0.3	NO
56	PSEN2	PSEN2	PSEN2	11247	-0.013	0.3	NO
57	HDAC5	HDAC5	HDAC5	11427	-0.016	0.29	NO
58	UBA52	UBA52	UBA52	11621	-0.019	0.28	NO
59	NUMB	NUMB	NUMB	11839	-0.023	0.27	NO
60	MIB2	MIB2	MIB2	11916	-0.024	0.27	NO
61	ARRB2	ARRB2	ARRB2	12408	-0.034	0.24	NO
62	HDAC8	HDAC8	HDAC8	13460	-0.054	0.19	NO
63	PSENEN	PSENEN	PSENEN	14134	-0.07	0.16	NO
64	HDAC6	HDAC6	HDAC6	14241	-0.073	0.17	NO
65	HDAC11	HDAC11	HDAC11	15275	-0.1	0.12	NO
66	HDAC10	HDAC10	HDAC10	15560	-0.11	0.12	NO
67	KAT2A	KAT2A	KAT2A	16176	-0.14	0.1	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	GLI2	GLI2	GLI2	6	0.83	0.017	YES
2	PDGFRA	PDGFRA	PDGFRA	20	0.76	0.033	YES
3	PTGS2	PTGS2	PTGS2	56	0.69	0.046	YES
4	FGF7	FGF7	FGF7	69	0.68	0.06	YES
5	LEF1	LEF1	LEF1	73	0.67	0.074	YES
6	FZD10	FZD10	FZD10	96	0.65	0.087	YES
7	RUNX1T1	RUNX1T1	RUNX1T1	169	0.59	0.095	YES
8	GLI1	GLI1	GLI1	183	0.58	0.11	YES
9	LAMC3	LAMC3	LAMC3	204	0.57	0.12	YES
10	WNT10A	WNT10A	WNT10A	213	0.57	0.13	YES
11	WNT4	WNT4	WNT4	236	0.55	0.14	YES
12	LAMB3	LAMB3	LAMB3	273	0.54	0.15	YES
13	IL6	IL6	IL6	280	0.53	0.16	YES
14	HGF	HGF	HGF	299	0.53	0.17	YES
15	PIK3CG	PIK3CG	PIK3CG	308	0.52	0.18	YES
16	CDKN2B	CDKN2B	CDKN2B	312	0.52	0.19	YES
17	PDGFRB	PDGFRB	PDGFRB	337	0.51	0.2	YES
18	FGF1	FGF1	FGF1	417	0.48	0.21	YES
19	RUNX1	RUNX1	RUNX1	458	0.48	0.22	YES
20	CCNA1	CCNA1	CCNA1	476	0.47	0.23	YES
21	IGF1	IGF1	IGF1	501	0.46	0.23	YES
22	TGFB2	TGFB2	TGFB2	588	0.44	0.24	YES
23	FGF18	FGF18	FGF18	601	0.44	0.25	YES
24	LAMA2	LAMA2	LAMA2	618	0.43	0.26	YES
25	MMP2	MMP2	MMP2	640	0.43	0.26	YES
26	WNT7A	WNT7A	WNT7A	654	0.42	0.27	YES
27	LAMA4	LAMA4	LAMA4	685	0.42	0.28	YES
28	DAPK2	DAPK2	DAPK2	693	0.42	0.29	YES
29	WNT9B	WNT9B	WNT9B	710	0.41	0.3	YES
30	FGF14	FGF14	FGF14	790	0.4	0.3	YES
31	WNT9A	WNT9A	WNT9A	844	0.39	0.3	YES
32	BRCA2	BRCA2	BRCA2	848	0.39	0.31	YES
33	FZD7	FZD7	FZD7	894	0.38	0.32	YES
34	RET	RET	RET	935	0.38	0.32	YES
35	FOS	FOS	FOS	974	0.37	0.33	YES
36	IL8	IL8	IL8	980	0.37	0.34	YES
37	LAMC2	LAMC2	LAMC2	1035	0.36	0.34	YES
38	TGFB3	TGFB3	TGFB3	1098	0.35	0.35	YES
39	HHIP	HHIP	HHIP	1138	0.35	0.35	YES
40	SLC2A1	SLC2A1	SLC2A1	1170	0.34	0.36	YES
41	ITGA2	ITGA2	ITGA2	1182	0.34	0.36	YES
42	ETS1	ETS1	ETS1	1199	0.34	0.37	YES
43	WNT6	WNT6	WNT6	1278	0.33	0.37	YES
44	RASSF5	RASSF5	RASSF5	1297	0.33	0.38	YES
45	TCF7	TCF7	TCF7	1311	0.32	0.39	YES
46	KIT	KIT	KIT	1332	0.32	0.39	YES
47	FN1	FN1	FN1	1446	0.31	0.39	YES
48	PTCH1	PTCH1	PTCH1	1451	0.31	0.4	YES
49	NOS2	NOS2	NOS2	1471	0.31	0.4	YES
50	DCC	DCC	DCC	1601	0.29	0.4	YES
51	TCF7L1	TCF7L1	TCF7L1	1727	0.28	0.4	YES
52	COL4A1	COL4A1	COL4A1	1802	0.28	0.4	YES
53	WNT7B	WNT7B	WNT7B	1898	0.27	0.4	YES
54	PRKCB	PRKCB	PRKCB	1909	0.27	0.41	YES
55	VEGFA	VEGFA	VEGFA	1922	0.26	0.41	YES
56	FASLG	FASLG	FASLG	1937	0.26	0.42	YES
57	MECOM	MECOM	MECOM	1962	0.26	0.42	YES
58	WNT8B	WNT8B	WNT8B	1967	0.26	0.43	YES
59	CDH1	CDH1	CDH1	1995	0.26	0.43	YES
60	PDGFB	PDGFB	PDGFB	2170	0.25	0.43	YES
61	CCNE2	CCNE2	CCNE2	2178	0.24	0.43	YES
62	NTRK1	NTRK1	NTRK1	2315	0.24	0.43	YES
63	CTNNA3	CTNNA3	CTNNA3	2346	0.23	0.43	YES
64	BIRC3	BIRC3	BIRC3	2414	0.23	0.44	YES
65	TGFB1	TGFB1	TGFB1	2461	0.22	0.44	YES
66	MAPK8	MAPK8	MAPK8	2503	0.22	0.44	YES
67	LAMA3	LAMA3	LAMA3	2527	0.22	0.44	YES
68	PGF	PGF	PGF	2613	0.21	0.44	YES
69	CCND1	CCND1	CCND1	2662	0.21	0.44	YES
70	TRAF3	TRAF3	TRAF3	2686	0.21	0.45	YES
71	EPAS1	EPAS1	EPAS1	2696	0.21	0.45	YES
72	COL4A6	COL4A6	COL4A6	2724	0.21	0.45	YES
73	PLCG2	PLCG2	PLCG2	2762	0.2	0.46	YES
74	RAC2	RAC2	RAC2	2846	0.2	0.46	YES
75	SKP2	SKP2	SKP2	2870	0.2	0.46	YES
76	TGFBR2	TGFBR2	TGFBR2	2889	0.2	0.46	YES
77	RXRG	RXRG	RXRG	2911	0.19	0.46	YES
78	VEGFC	VEGFC	VEGFC	2940	0.19	0.47	YES
79	NKX3-1	NKX3-1	NKX3-1	2957	0.19	0.47	YES
80	TGFA	TGFA	TGFA	3027	0.19	0.47	YES
81	PIK3CA	PIK3CA	PIK3CA	3044	0.19	0.47	YES
82	FOXO1	FOXO1	FOXO1	3062	0.18	0.48	YES
83	EGLN3	EGLN3	EGLN3	3084	0.18	0.48	YES
84	FLT3	FLT3	FLT3	3095	0.18	0.48	YES
85	ITGAV	ITGAV	ITGAV	3137	0.18	0.48	YES
86	BMP2	BMP2	BMP2	3187	0.18	0.49	YES
87	KITLG	KITLG	KITLG	3204	0.18	0.49	YES
88	FGF13	FGF13	FGF13	3249	0.17	0.49	YES
89	MMP1	MMP1	MMP1	3309	0.17	0.49	YES
90	DAPK1	DAPK1	DAPK1	3317	0.17	0.49	YES
91	PTCH2	PTCH2	PTCH2	3320	0.17	0.5	YES
92	FZD3	FZD3	FZD3	3445	0.16	0.49	YES
93	CSF1R	CSF1R	CSF1R	3509	0.16	0.49	YES
94	COL4A2	COL4A2	COL4A2	3595	0.16	0.49	YES
95	BMP4	BMP4	BMP4	3686	0.15	0.49	YES
96	COL4A4	COL4A4	COL4A4	3769	0.15	0.49	YES
97	PIAS2	PIAS2	PIAS2	3777	0.15	0.49	YES
98	MMP9	MMP9	MMP9	3797	0.15	0.49	YES
99	PIAS3	PIAS3	PIAS3	3821	0.15	0.5	YES
100	CBLB	CBLB	CBLB	3855	0.15	0.5	YES
101	ITGB1	ITGB1	ITGB1	3869	0.15	0.5	YES
102	PPARD	PPARD	PPARD	3924	0.14	0.5	YES
103	FGF12	FGF12	FGF12	3937	0.14	0.5	YES
104	PIK3R5	PIK3R5	PIK3R5	3956	0.14	0.5	YES
105	TRAF6	TRAF6	TRAF6	4078	0.14	0.5	YES
106	SHH	SHH	SHH	4079	0.14	0.5	YES
107	WNT3A	WNT3A	WNT3A	4083	0.14	0.51	YES
108	E2F2	E2F2	E2F2	4088	0.14	0.51	YES
109	TRAF5	TRAF5	TRAF5	4089	0.14	0.51	YES
110	EP300	EP300	EP300	4158	0.14	0.51	YES
111	RXRA	RXRA	RXRA	4184	0.13	0.51	YES
112	PIAS1	PIAS1	PIAS1	4266	0.13	0.51	YES
113	WNT1	WNT1	WNT1	4332	0.13	0.51	YES
114	HIF1A	HIF1A	HIF1A	4370	0.13	0.51	YES
115	EGFR	EGFR	EGFR	4399	0.13	0.51	YES
116	FZD6	FZD6	FZD6	4407	0.13	0.51	YES
117	WNT2	WNT2	WNT2	4437	0.12	0.52	YES
118	LAMC1	LAMC1	LAMC1	4484	0.12	0.52	YES
119	MSH6	MSH6	MSH6	4545	0.12	0.51	YES
120	FGF9	FGF9	FGF9	4559	0.12	0.52	YES
121	TGFBR1	TGFBR1	TGFBR1	4669	0.12	0.51	YES
122	WNT16	WNT16	WNT16	4689	0.12	0.51	YES
123	JUN	JUN	JUN	4720	0.12	0.51	YES
124	SPI1	SPI1	SPI1	4739	0.11	0.52	YES
125	VHL	VHL	VHL	4800	0.11	0.52	YES
126	MSH2	MSH2	MSH2	4855	0.11	0.51	YES
127	HDAC1	HDAC1	HDAC1	4871	0.11	0.52	YES
128	CBL	CBL	CBL	4887	0.11	0.52	YES
129	CDKN2A	CDKN2A	CDKN2A	4933	0.11	0.52	YES
130	RAD51	RAD51	RAD51	4945	0.11	0.52	YES
131	FAS	FAS	FAS	4980	0.11	0.52	YES
132	RALGDS	RALGDS	RALGDS	5030	0.1	0.52	YES
133	CSF2RA	CSF2RA	CSF2RA	5051	0.1	0.52	YES
134	TCF7L2	TCF7L2	TCF7L2	5069	0.1	0.52	YES
135	RB1	RB1	RB1	5073	0.1	0.52	YES
136	RALBP1	RALBP1	RALBP1	5139	0.1	0.52	NO
137	ARNT2	ARNT2	ARNT2	5185	0.1	0.52	NO
138	PTEN	PTEN	PTEN	5398	0.094	0.51	NO
139	SOS1	SOS1	SOS1	5404	0.094	0.51	NO
140	MAP2K1	MAP2K1	MAP2K1	5407	0.094	0.51	NO
141	CDKN1B	CDKN1B	CDKN1B	5434	0.093	0.52	NO
142	BRAF	BRAF	BRAF	5446	0.092	0.52	NO
143	CSF3R	CSF3R	CSF3R	5509	0.091	0.52	NO
144	CRKL	CRKL	CRKL	5518	0.09	0.52	NO
145	TPR	TPR	TPR	5618	0.088	0.51	NO
146	NFKB1	NFKB1	NFKB1	5646	0.087	0.51	NO
147	CTNNB1	CTNNB1	CTNNB1	5708	0.086	0.51	NO
148	FIGF	FIGF	FIGF	5756	0.084	0.51	NO
149	AKT3	AKT3	AKT3	5768	0.084	0.51	NO
150	PIK3CD	PIK3CD	PIK3CD	5819	0.083	0.51	NO
151	RARB	RARB	RARB	5821	0.083	0.51	NO
152	HDAC2	HDAC2	HDAC2	5907	0.081	0.51	NO
153	STAT1	STAT1	STAT1	5926	0.08	0.51	NO
154	FGF11	FGF11	FGF11	5930	0.08	0.51	NO
155	RARA	RARA	RARA	5955	0.08	0.51	NO
156	XIAP	XIAP	XIAP	5990	0.079	0.51	NO
157	NFKBIA	NFKBIA	NFKBIA	5995	0.079	0.51	NO
158	STAT3	STAT3	STAT3	6195	0.075	0.5	NO
159	JAK1	JAK1	JAK1	6235	0.074	0.5	NO
160	ITGA3	ITGA3	ITGA3	6247	0.074	0.5	NO
161	SMAD3	SMAD3	SMAD3	6276	0.073	0.5	NO
162	PIAS4	PIAS4	PIAS4	6319	0.072	0.5	NO
163	STK4	STK4	STK4	6321	0.072	0.5	NO
164	RELA	RELA	RELA	6404	0.07	0.5	NO
165	NRAS	NRAS	NRAS	6436	0.07	0.5	NO
166	SMAD2	SMAD2	SMAD2	6463	0.069	0.5	NO
167	CRK	CRK	CRK	6505	0.068	0.5	NO
168	IGF1R	IGF1R	IGF1R	6594	0.066	0.5	NO
169	APPL1	APPL1	APPL1	6621	0.066	0.5	NO
170	CTBP2	CTBP2	CTBP2	6826	0.061	0.49	NO
171	BIRC2	BIRC2	BIRC2	6870	0.06	0.48	NO
172	APC	APC	APC	6873	0.06	0.49	NO
173	CASP3	CASP3	CASP3	6967	0.059	0.48	NO
174	BCR	BCR	BCR	6968	0.059	0.48	NO
175	FGF20	FGF20	FGF20	7112	0.056	0.48	NO
176	AXIN2	AXIN2	AXIN2	7142	0.055	0.48	NO
177	CDK6	CDK6	CDK6	7150	0.055	0.48	NO
178	PTK2	PTK2	PTK2	7167	0.055	0.48	NO
179	NFKB2	NFKB2	NFKB2	7172	0.055	0.48	NO
180	PML	PML	PML	7185	0.054	0.48	NO
181	LAMA5	LAMA5	LAMA5	7211	0.054	0.48	NO
182	ARNT	ARNT	ARNT	7217	0.054	0.48	NO
183	GLI3	GLI3	GLI3	7257	0.053	0.48	NO
184	MAPK1	MAPK1	MAPK1	7286	0.052	0.48	NO
185	E2F3	E2F3	E2F3	7340	0.052	0.48	NO
186	CDK2	CDK2	CDK2	7456	0.049	0.47	NO
187	WNT10B	WNT10B	WNT10B	7490	0.049	0.47	NO
188	EGLN1	EGLN1	EGLN1	7493	0.049	0.47	NO
189	CDC42	CDC42	CDC42	7513	0.048	0.47	NO
190	SOS2	SOS2	SOS2	7514	0.048	0.47	NO
191	CREBBP	CREBBP	CREBBP	7530	0.048	0.47	NO
192	FGF2	FGF2	FGF2	7555	0.048	0.47	NO
193	FGFR1	FGFR1	FGFR1	7626	0.046	0.47	NO
194	JUP	JUP	JUP	7663	0.046	0.47	NO
195	CDKN1A	CDKN1A	CDKN1A	7688	0.045	0.47	NO
196	PIK3R1	PIK3R1	PIK3R1	7744	0.044	0.46	NO
197	ABL1	ABL1	ABL1	7762	0.044	0.46	NO
198	GSK3B	GSK3B	GSK3B	7929	0.041	0.46	NO
199	MSH3	MSH3	MSH3	7999	0.04	0.45	NO
200	AKT1	AKT1	AKT1	8012	0.04	0.45	NO
201	CKS1B	CKS1B	CKS1B	8068	0.039	0.45	NO
202	SMAD4	SMAD4	SMAD4	8086	0.039	0.45	NO
203	CCDC6	CCDC6	CCDC6	8175	0.038	0.45	NO
204	AR	AR	AR	8216	0.037	0.44	NO
205	CUL2	CUL2	CUL2	8227	0.037	0.44	NO
206	MTOR	MTOR	MTOR	8328	0.035	0.44	NO
207	TPM3	TPM3	TPM3	8430	0.033	0.44	NO
208	DVL1	DVL1	DVL1	8606	0.03	0.43	NO
209	RASSF1	RASSF1	RASSF1	8677	0.029	0.42	NO
210	PIK3CB	PIK3CB	PIK3CB	8701	0.028	0.42	NO
211	MYC	MYC	MYC	8752	0.028	0.42	NO
212	KLK3	KLK3	KLK3	8774	0.027	0.42	NO
213	ERBB2	ERBB2	ERBB2	8805	0.027	0.42	NO
214	LAMB2	LAMB2	LAMB2	8813	0.027	0.42	NO
215	PIK3R3	PIK3R3	PIK3R3	9002	0.024	0.41	NO
216	BID	BID	BID	9048	0.023	0.41	NO
217	MAPK10	MAPK10	MAPK10	9218	0.02	0.4	NO
218	HSP90B1	HSP90B1	HSP90B1	9228	0.02	0.4	NO
219	KRAS	KRAS	KRAS	9234	0.02	0.4	NO
220	BIRC5	BIRC5	BIRC5	9252	0.02	0.4	NO
221	SUFU	SUFU	SUFU	9367	0.018	0.39	NO
222	ARAF	ARAF	ARAF	9405	0.017	0.39	NO
223	MDM2	MDM2	MDM2	9442	0.017	0.39	NO
224	RHOA	RHOA	RHOA	9523	0.016	0.38	NO
225	RXRB	RXRB	RXRB	9531	0.015	0.38	NO
226	DVL3	DVL3	DVL3	9533	0.015	0.38	NO
227	FZD8	FZD8	FZD8	9581	0.014	0.38	NO
228	PDGFA	PDGFA	PDGFA	9608	0.014	0.38	NO
229	DAPK3	DAPK3	DAPK3	9615	0.014	0.38	NO
230	AKT2	AKT2	AKT2	9624	0.014	0.38	NO
231	TP53	TP53	TP53	9629	0.014	0.38	NO
232	RAF1	RAF1	RAF1	9646	0.014	0.38	NO
233	CCNE1	CCNE1	CCNE1	9848	0.01	0.37	NO
234	STAT5B	STAT5B	STAT5B	9877	0.01	0.37	NO
235	FLT3LG	FLT3LG	FLT3LG	9888	0.0098	0.37	NO
236	RALA	RALA	RALA	9938	0.0089	0.36	NO
237	HSP90AB1	HSP90AB1	HSP90AB1	9939	0.0089	0.36	NO
238	HSP90AA1	HSP90AA1	HSP90AA1	9952	0.0087	0.36	NO
239	NCOA4	NCOA4	NCOA4	10024	0.0075	0.36	NO
240	CTNNA1	CTNNA1	CTNNA1	10107	0.006	0.36	NO
241	IKBKB	IKBKB	IKBKB	10283	0.0031	0.34	NO
242	CASP9	CASP9	CASP9	10360	0.0016	0.34	NO
243	BCL2	BCL2	BCL2	10423	0.00083	0.34	NO
244	FGFR2	FGFR2	FGFR2	10500	-0.00067	0.33	NO
245	MLH1	MLH1	MLH1	10501	-0.00068	0.33	NO
246	ITGA6	ITGA6	ITGA6	10573	-0.0016	0.33	NO
247	GSTP1	GSTP1	GSTP1	10591	-0.0019	0.33	NO
248	MET	MET	MET	10604	-0.0021	0.33	NO
249	RBX1	RBX1	RBX1	10746	-0.0046	0.32	NO
250	IKBKG	IKBKG	IKBKG	10750	-0.0046	0.32	NO
251	MAPK3	MAPK3	MAPK3	10867	-0.0068	0.31	NO
252	MAX	MAX	MAX	10909	-0.0075	0.31	NO
253	EGLN2	EGLN2	EGLN2	10916	-0.0076	0.31	NO
254	FZD2	FZD2	FZD2	10951	-0.0082	0.31	NO
255	RALB	RALB	RALB	10976	-0.0087	0.31	NO
256	WNT5B	WNT5B	WNT5B	11042	-0.0096	0.3	NO
257	FZD4	FZD4	FZD4	11051	-0.0098	0.3	NO
258	WNT3	WNT3	WNT3	11076	-0.01	0.3	NO
259	CHUK	CHUK	CHUK	11102	-0.01	0.3	NO
260	CASP8	CASP8	CASP8	11193	-0.012	0.3	NO
261	ZBTB16	ZBTB16	ZBTB16	11291	-0.013	0.29	NO
262	TRAF1	TRAF1	TRAF1	11338	-0.014	0.29	NO
263	MAPK9	MAPK9	MAPK9	11373	-0.015	0.29	NO
264	STAT5A	STAT5A	STAT5A	11375	-0.015	0.29	NO
265	E2F1	E2F1	E2F1	11598	-0.019	0.28	NO
266	ITGA2B	ITGA2B	ITGA2B	11604	-0.019	0.28	NO
267	RAC1	RAC1	RAC1	11607	-0.019	0.28	NO
268	FZD5	FZD5	FZD5	11681	-0.02	0.27	NO
269	CBLC	CBLC	CBLC	11768	-0.022	0.27	NO
270	LAMB1	LAMB1	LAMB1	11824	-0.022	0.26	NO
271	MITF	MITF	MITF	11984	-0.026	0.26	NO
272	FZD9	FZD9	FZD9	11988	-0.026	0.26	NO
273	PIK3R2	PIK3R2	PIK3R2	12062	-0.027	0.25	NO
274	PRKCA	PRKCA	PRKCA	12074	-0.027	0.25	NO
275	CTBP1	CTBP1	CTBP1	12192	-0.03	0.25	NO
276	LAMB4	LAMB4	LAMB4	12540	-0.036	0.23	NO
277	TFG	TFG	TFG	12678	-0.039	0.22	NO
278	CDK4	CDK4	CDK4	12681	-0.039	0.22	NO
279	FADD	FADD	FADD	12695	-0.039	0.22	NO
280	HRAS	HRAS	HRAS	12706	-0.039	0.22	NO
281	BCL2L1	BCL2L1	BCL2L1	12774	-0.041	0.22	NO
282	DVL2	DVL2	DVL2	12897	-0.043	0.21	NO
283	PLCG1	PLCG1	PLCG1	13005	-0.045	0.21	NO
284	GRB2	GRB2	GRB2	13043	-0.046	0.21	NO
285	FZD1	FZD1	FZD1	13052	-0.046	0.21	NO
286	TCEB1	TCEB1	TCEB1	13084	-0.047	0.21	NO
287	BAX	BAX	BAX	13168	-0.049	0.2	NO
288	MAP2K2	MAP2K2	MAP2K2	13169	-0.049	0.2	NO
289	AXIN1	AXIN1	AXIN1	13270	-0.05	0.2	NO
290	FGFR3	FGFR3	FGFR3	13315	-0.052	0.2	NO
291	STK36	STK36	STK36	13327	-0.052	0.2	NO
292	TRAF4	TRAF4	TRAF4	13556	-0.056	0.19	NO
293	FGF5	FGF5	FGF5	13593	-0.057	0.19	NO
294	PAX8	PAX8	PAX8	13601	-0.057	0.19	NO
295	FGF22	FGF22	FGF22	13617	-0.058	0.19	NO
296	BAD	BAD	BAD	13942	-0.065	0.17	NO
297	WNT5A	WNT5A	WNT5A	14514	-0.081	0.14	NO
298	TRAF2	TRAF2	TRAF2	14583	-0.083	0.14	NO
299	WNT11	WNT11	WNT11	14618	-0.084	0.14	NO
300	PLD1	PLD1	PLD1	14682	-0.086	0.14	NO
301	PPARG	PPARG	PPARG	14913	-0.092	0.13	NO
302	WNT2B	WNT2B	WNT2B	14946	-0.093	0.13	NO
303	VEGFB	VEGFB	VEGFB	15263	-0.1	0.11	NO
304	CEBPA	CEBPA	CEBPA	15309	-0.1	0.11	NO
305	APC2	APC2	APC2	15344	-0.11	0.11	NO
306	FH	FH	FH	15579	-0.12	0.1	NO
307	CYCS	CYCS	CYCS	15724	-0.12	0.094	NO
308	FGF17	FGF17	FGF17	15844	-0.12	0.09	NO
309	SMO	SMO	SMO	16055	-0.14	0.081	NO
310	LAMA1	LAMA1	LAMA1	16177	-0.14	0.077	NO
311	TCEB2	TCEB2	TCEB2	16270	-0.15	0.075	NO
312	CTNNA2	CTNNA2	CTNNA2	16772	-0.18	0.051	NO
313	EGF	EGF	EGF	16931	-0.19	0.046	NO
314	PRKCG	PRKCG	PRKCG	16936	-0.19	0.05	NO
315	FGF8	FGF8	FGF8	17088	-0.21	0.046	NO
316	RAC3	RAC3	RAC3	17236	-0.23	0.042	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	PIK3CG	PIK3CG	PIK3CG	308	0.52	0.057	YES
2	RUNX1	RUNX1	RUNX1	458	0.48	0.12	YES
3	TGFB2	TGFB2	TGFB2	588	0.44	0.17	YES
4	SHC3	SHC3	SHC3	660	0.42	0.23	YES
5	TGFB3	TGFB3	TGFB3	1098	0.35	0.25	YES
6	SHC4	SHC4	SHC4	1236	0.34	0.29	YES
7	MECOM	MECOM	MECOM	1962	0.26	0.29	YES
8	TGFB1	TGFB1	TGFB1	2461	0.22	0.29	YES
9	CCND1	CCND1	CCND1	2662	0.21	0.31	YES
10	TGFBR2	TGFBR2	TGFBR2	2889	0.2	0.33	YES
11	PIK3CA	PIK3CA	PIK3CA	3044	0.19	0.35	YES
12	CBLB	CBLB	CBLB	3855	0.15	0.32	YES
13	PIK3R5	PIK3R5	PIK3R5	3956	0.14	0.34	YES
14	E2F2	E2F2	E2F2	4088	0.14	0.35	YES
15	TGFBR1	TGFBR1	TGFBR1	4669	0.12	0.33	YES
16	HDAC1	HDAC1	HDAC1	4871	0.11	0.34	YES
17	CBL	CBL	CBL	4887	0.11	0.35	YES
18	CDKN2A	CDKN2A	CDKN2A	4933	0.11	0.36	YES
19	RB1	RB1	RB1	5073	0.1	0.37	YES
20	SOS1	SOS1	SOS1	5404	0.094	0.37	YES
21	MAP2K1	MAP2K1	MAP2K1	5407	0.094	0.38	YES
22	CDKN1B	CDKN1B	CDKN1B	5434	0.093	0.39	YES
23	BRAF	BRAF	BRAF	5446	0.092	0.4	YES
24	CRKL	CRKL	CRKL	5518	0.09	0.41	YES
25	NFKB1	NFKB1	NFKB1	5646	0.087	0.42	YES
26	AKT3	AKT3	AKT3	5768	0.084	0.42	YES
27	PIK3CD	PIK3CD	PIK3CD	5819	0.083	0.43	YES
28	HDAC2	HDAC2	HDAC2	5907	0.081	0.44	YES
29	SHC1	SHC1	SHC1	5967	0.079	0.45	YES
30	NFKBIA	NFKBIA	NFKBIA	5995	0.079	0.46	YES
31	SMAD3	SMAD3	SMAD3	6276	0.073	0.45	YES
32	RELA	RELA	RELA	6404	0.07	0.45	YES
33	NRAS	NRAS	NRAS	6436	0.07	0.46	YES
34	CRK	CRK	CRK	6505	0.068	0.47	YES
35	CTBP2	CTBP2	CTBP2	6826	0.061	0.46	NO
36	BCR	BCR	BCR	6968	0.059	0.46	NO
37	CDK6	CDK6	CDK6	7150	0.055	0.46	NO
38	MAPK1	MAPK1	MAPK1	7286	0.052	0.46	NO
39	E2F3	E2F3	E2F3	7340	0.052	0.46	NO
40	SOS2	SOS2	SOS2	7514	0.048	0.46	NO
41	CDKN1A	CDKN1A	CDKN1A	7688	0.045	0.46	NO
42	PIK3R1	PIK3R1	PIK3R1	7744	0.044	0.46	NO
43	ABL1	ABL1	ABL1	7762	0.044	0.46	NO
44	GAB2	GAB2	GAB2	7911	0.042	0.46	NO
45	AKT1	AKT1	AKT1	8012	0.04	0.46	NO
46	SMAD4	SMAD4	SMAD4	8086	0.039	0.46	NO
47	PIK3CB	PIK3CB	PIK3CB	8701	0.028	0.43	NO
48	MYC	MYC	MYC	8752	0.028	0.43	NO
49	PIK3R3	PIK3R3	PIK3R3	9002	0.024	0.42	NO
50	KRAS	KRAS	KRAS	9234	0.02	0.41	NO
51	ARAF	ARAF	ARAF	9405	0.017	0.41	NO
52	MDM2	MDM2	MDM2	9442	0.017	0.41	NO
53	AKT2	AKT2	AKT2	9624	0.014	0.4	NO
54	TP53	TP53	TP53	9629	0.014	0.4	NO
55	RAF1	RAF1	RAF1	9646	0.014	0.4	NO
56	STAT5B	STAT5B	STAT5B	9877	0.01	0.39	NO
57	PTPN11	PTPN11	PTPN11	10221	0.0041	0.37	NO
58	IKBKB	IKBKB	IKBKB	10283	0.0031	0.37	NO
59	IKBKG	IKBKG	IKBKG	10750	-0.0046	0.34	NO
60	MAPK3	MAPK3	MAPK3	10867	-0.0068	0.34	NO
61	CHUK	CHUK	CHUK	11102	-0.01	0.32	NO
62	STAT5A	STAT5A	STAT5A	11375	-0.015	0.31	NO
63	E2F1	E2F1	E2F1	11598	-0.019	0.3	NO
64	SHC2	SHC2	SHC2	11635	-0.019	0.3	NO
65	CBLC	CBLC	CBLC	11768	-0.022	0.3	NO
66	PIK3R2	PIK3R2	PIK3R2	12062	-0.027	0.29	NO
67	CTBP1	CTBP1	CTBP1	12192	-0.03	0.28	NO
68	CDK4	CDK4	CDK4	12681	-0.039	0.26	NO
69	HRAS	HRAS	HRAS	12706	-0.039	0.27	NO
70	BCL2L1	BCL2L1	BCL2L1	12774	-0.041	0.27	NO
71	GRB2	GRB2	GRB2	13043	-0.046	0.26	NO
72	MAP2K2	MAP2K2	MAP2K2	13169	-0.049	0.26	NO
73	BAD	BAD	BAD	13942	-0.065	0.23	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	NTF3	NTF3	NTF3	156	0.6	0.036	YES
2	CAMK4	CAMK4	CAMK4	164	0.59	0.08	YES
3	PIK3CG	PIK3CG	PIK3CG	308	0.52	0.11	YES
4	RPS6KA5	RPS6KA5	RPS6KA5	362	0.5	0.14	YES
5	IRAK3	IRAK3	IRAK3	497	0.46	0.17	YES
6	NGFR	NGFR	NGFR	532	0.46	0.2	YES
7	SHC3	SHC3	SHC3	660	0.42	0.23	YES
8	CAMK2A	CAMK2A	CAMK2A	1005	0.36	0.24	YES
9	NGF	NGF	NGF	1100	0.35	0.26	YES
10	SHC4	SHC4	SHC4	1236	0.34	0.28	YES
11	NTRK3	NTRK3	NTRK3	1769	0.28	0.27	YES
12	MAP3K5	MAP3K5	MAP3K5	1786	0.28	0.29	YES
13	FASLG	FASLG	FASLG	1937	0.26	0.3	YES
14	IRAK2	IRAK2	IRAK2	1979	0.26	0.32	YES
15	IRS1	IRS1	IRS1	2138	0.25	0.32	YES
16	IRS2	IRS2	IRS2	2212	0.24	0.34	YES
17	NTRK1	NTRK1	NTRK1	2315	0.24	0.35	YES
18	MAPK13	MAPK13	MAPK13	2421	0.23	0.36	YES
19	RPS6KA6	RPS6KA6	RPS6KA6	2443	0.23	0.38	YES
20	PDK1	PDK1	PDK1	2469	0.22	0.39	YES
21	MAPK8	MAPK8	MAPK8	2503	0.22	0.41	YES
22	SH2B3	SH2B3	SH2B3	2570	0.22	0.42	YES
23	PLCG2	PLCG2	PLCG2	2762	0.2	0.42	YES
24	ARHGDIB	ARHGDIB	ARHGDIB	2915	0.19	0.43	YES
25	PIK3CA	PIK3CA	PIK3CA	3044	0.19	0.44	YES
26	SH2B2	SH2B2	SH2B2	3108	0.18	0.45	YES
27	RPS6KA2	RPS6KA2	RPS6KA2	3247	0.18	0.45	YES
28	RIPK2	RIPK2	RIPK2	3749	0.15	0.44	NO
29	PIK3R5	PIK3R5	PIK3R5	3956	0.14	0.44	NO
30	TRAF6	TRAF6	TRAF6	4078	0.14	0.44	NO
31	NTRK2	NTRK2	NTRK2	4267	0.13	0.44	NO
32	NTF4	NTF4	NTF4	4544	0.12	0.43	NO
33	JUN	JUN	JUN	4720	0.12	0.43	NO
34	MAP3K1	MAP3K1	MAP3K1	5011	0.1	0.42	NO
35	SORT1	SORT1	SORT1	5330	0.096	0.41	NO
36	SOS1	SOS1	SOS1	5404	0.094	0.42	NO
37	CALML3	CALML3	CALML3	5406	0.094	0.42	NO
38	MAP2K1	MAP2K1	MAP2K1	5407	0.094	0.43	NO
39	BRAF	BRAF	BRAF	5446	0.092	0.43	NO
40	CRKL	CRKL	CRKL	5518	0.09	0.44	NO
41	NFKB1	NFKB1	NFKB1	5646	0.087	0.44	NO
42	AKT3	AKT3	AKT3	5768	0.084	0.44	NO
43	PIK3CD	PIK3CD	PIK3CD	5819	0.083	0.44	NO
44	FRS2	FRS2	FRS2	5830	0.083	0.44	NO
45	SHC1	SHC1	SHC1	5967	0.079	0.44	NO
46	NFKBIA	NFKBIA	NFKBIA	5995	0.079	0.45	NO
47	FOXO3	FOXO3	FOXO3	6274	0.073	0.44	NO
48	GAB1	GAB1	GAB1	6403	0.07	0.44	NO
49	RELA	RELA	RELA	6404	0.07	0.44	NO
50	NRAS	NRAS	NRAS	6436	0.07	0.44	NO
51	RAP1A	RAP1A	RAP1A	6443	0.07	0.45	NO
52	CRK	CRK	CRK	6505	0.068	0.45	NO
53	KIDINS220	KIDINS220	KIDINS220	6551	0.067	0.45	NO
54	RPS6KA3	RPS6KA3	RPS6KA3	6634	0.066	0.45	NO
55	YWHAZ	YWHAZ	YWHAZ	6866	0.061	0.44	NO
56	ZNF274	ZNF274	ZNF274	7066	0.057	0.44	NO
57	MAP3K3	MAP3K3	MAP3K3	7134	0.055	0.44	NO
58	RAPGEF1	RAPGEF1	RAPGEF1	7252	0.053	0.44	NO
59	MAPK1	MAPK1	MAPK1	7286	0.052	0.44	NO
60	PRKCD	PRKCD	PRKCD	7473	0.049	0.43	NO
61	CDC42	CDC42	CDC42	7513	0.048	0.43	NO
62	SOS2	SOS2	SOS2	7514	0.048	0.44	NO
63	PIK3R1	PIK3R1	PIK3R1	7744	0.044	0.43	NO
64	ABL1	ABL1	ABL1	7762	0.044	0.43	NO
65	CSK	CSK	CSK	7765	0.044	0.43	NO
66	TP73	TP73	TP73	7823	0.043	0.43	NO
67	GSK3B	GSK3B	GSK3B	7929	0.041	0.43	NO
68	AKT1	AKT1	AKT1	8012	0.04	0.43	NO
69	NFKBIE	NFKBIE	NFKBIE	8021	0.04	0.43	NO
70	YWHAB	YWHAB	YWHAB	8500	0.032	0.41	NO
71	ATF4	ATF4	ATF4	8651	0.029	0.4	NO
72	PIK3CB	PIK3CB	PIK3CB	8701	0.028	0.4	NO
73	PSEN1	PSEN1	PSEN1	8850	0.026	0.39	NO
74	MAPK14	MAPK14	MAPK14	8871	0.026	0.39	NO
75	PIK3R3	PIK3R3	PIK3R3	9002	0.024	0.39	NO
76	MAPK10	MAPK10	MAPK10	9218	0.02	0.38	NO
77	KRAS	KRAS	KRAS	9234	0.02	0.38	NO
78	MAPKAPK2	MAPKAPK2	MAPKAPK2	9371	0.018	0.37	NO
79	IRAK4	IRAK4	IRAK4	9378	0.018	0.37	NO
80	CALM1	CALM1	CALM1	9493	0.016	0.37	NO
81	YWHAQ	YWHAQ	YWHAQ	9501	0.016	0.37	NO
82	MAP2K7	MAP2K7	MAP2K7	9504	0.016	0.37	NO
83	RHOA	RHOA	RHOA	9523	0.016	0.37	NO
84	AKT2	AKT2	AKT2	9624	0.014	0.36	NO
85	TP53	TP53	TP53	9629	0.014	0.37	NO
86	RAF1	RAF1	RAF1	9646	0.014	0.37	NO
87	MAGED1	MAGED1	MAGED1	9679	0.013	0.36	NO
88	RPS6KA4	RPS6KA4	RPS6KA4	9821	0.011	0.36	NO
89	CALM2	CALM2	CALM2	9831	0.011	0.36	NO
90	YWHAH	YWHAH	YWHAH	9870	0.01	0.36	NO
91	RAP1B	RAP1B	RAP1B	10049	0.0071	0.35	NO
92	CAMK2D	CAMK2D	CAMK2D	10117	0.006	0.34	NO
93	YWHAG	YWHAG	YWHAG	10141	0.0054	0.34	NO
94	CALM3	CALM3	CALM3	10214	0.0042	0.34	NO
95	PTPN11	PTPN11	PTPN11	10221	0.0041	0.34	NO
96	IKBKB	IKBKB	IKBKB	10283	0.0031	0.34	NO
97	BCL2	BCL2	BCL2	10423	0.00083	0.33	NO
98	CAMK2G	CAMK2G	CAMK2G	10465	-0.000041	0.33	NO
99	MAPK11	MAPK11	MAPK11	10523	-0.00091	0.32	NO
100	MAPK3	MAPK3	MAPK3	10867	-0.0068	0.3	NO
101	MAPK9	MAPK9	MAPK9	11373	-0.015	0.28	NO
102	MAPK7	MAPK7	MAPK7	11388	-0.015	0.28	NO
103	YWHAE	YWHAE	YWHAE	11529	-0.018	0.27	NO
104	RAC1	RAC1	RAC1	11607	-0.019	0.27	NO
105	SHC2	SHC2	SHC2	11635	-0.019	0.27	NO
106	NGFRAP1	NGFRAP1	NGFRAP1	11750	-0.021	0.26	NO
107	CALML6	CALML6	CALML6	12013	-0.026	0.25	NO
108	ARHGDIA	ARHGDIA	ARHGDIA	12046	-0.027	0.25	NO
109	PIK3R2	PIK3R2	PIK3R2	12062	-0.027	0.25	NO
110	PRDM4	PRDM4	PRDM4	12144	-0.028	0.25	NO
111	IRAK1	IRAK1	IRAK1	12303	-0.032	0.24	NO
112	MAP2K5	MAP2K5	MAP2K5	12352	-0.032	0.24	NO
113	HRAS	HRAS	HRAS	12706	-0.039	0.23	NO
114	PLCG1	PLCG1	PLCG1	13005	-0.045	0.21	NO
115	GRB2	GRB2	GRB2	13043	-0.046	0.21	NO
116	BAX	BAX	BAX	13168	-0.049	0.21	NO
117	MAP2K2	MAP2K2	MAP2K2	13169	-0.049	0.21	NO
118	RPS6KA1	RPS6KA1	RPS6KA1	13604	-0.057	0.19	NO
119	BDNF	BDNF	BDNF	13920	-0.065	0.18	NO
120	BAD	BAD	BAD	13942	-0.065	0.18	NO
121	NFKBIB	NFKBIB	NFKBIB	14192	-0.072	0.18	NO
122	SH2B1	SH2B1	SH2B1	15546	-0.11	0.11	NO
123	CAMK2B	CAMK2B	CAMK2B	16523	-0.16	0.067	NO
124	MAPK12	MAPK12	MAPK12	17008	-0.2	0.054	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	PDGFRA	PDGFRA	PDGFRA	20	0.76	0.022	YES
2	ITGA8	ITGA8	ITGA8	27	0.74	0.044	YES
3	ITGA9	ITGA9	ITGA9	84	0.66	0.061	YES
4	COL6A3	COL6A3	COL6A3	91	0.65	0.08	YES
5	COL5A1	COL5A1	COL5A1	123	0.62	0.097	YES
6	ITGA11	ITGA11	ITGA11	168	0.59	0.11	YES
7	COL3A1	COL3A1	COL3A1	178	0.59	0.13	YES
8	LAMC3	LAMC3	LAMC3	204	0.57	0.15	YES
9	LAMB3	LAMB3	LAMB3	273	0.54	0.16	YES
10	COL5A2	COL5A2	COL5A2	291	0.53	0.17	YES
11	HGF	HGF	HGF	299	0.53	0.19	YES
12	PIK3CG	PIK3CG	PIK3CG	308	0.52	0.2	YES
13	COMP	COMP	COMP	323	0.52	0.22	YES
14	ITGA10	ITGA10	ITGA10	334	0.51	0.23	YES
15	PDGFRB	PDGFRB	PDGFRB	337	0.51	0.25	YES
16	ITGB6	ITGB6	ITGB6	399	0.49	0.26	YES
17	IGF1	IGF1	IGF1	501	0.46	0.27	YES
18	KDR	KDR	KDR	515	0.46	0.28	YES
19	ITGA4	ITGA4	ITGA4	528	0.46	0.3	YES
20	COL11A1	COL11A1	COL11A1	541	0.45	0.31	YES
21	TNN	TNN	TNN	608	0.44	0.32	YES
22	COL1A1	COL1A1	COL1A1	616	0.43	0.33	YES
23	LAMA2	LAMA2	LAMA2	618	0.43	0.34	YES
24	SHC3	SHC3	SHC3	660	0.42	0.35	YES
25	LAMA4	LAMA4	LAMA4	685	0.42	0.37	YES
26	PAK6	PAK6	PAK6	698	0.42	0.38	YES
27	TNXB	TNXB	TNXB	749	0.41	0.39	YES
28	FLT4	FLT4	FLT4	853	0.39	0.39	YES
29	COL1A2	COL1A2	COL1A2	904	0.38	0.4	YES
30	LAMC2	LAMC2	LAMC2	1035	0.36	0.4	YES
31	TNC	TNC	TNC	1057	0.36	0.42	YES
32	IBSP	IBSP	IBSP	1090	0.35	0.42	YES
33	ITGA1	ITGA1	ITGA1	1144	0.35	0.43	YES
34	ITGA2	ITGA2	ITGA2	1182	0.34	0.44	YES
35	SHC4	SHC4	SHC4	1236	0.34	0.45	YES
36	FLT1	FLT1	FLT1	1307	0.33	0.45	YES
37	COL6A2	COL6A2	COL6A2	1342	0.32	0.46	YES
38	ITGB3	ITGB3	ITGB3	1356	0.32	0.47	YES
39	FN1	FN1	FN1	1446	0.31	0.47	YES
40	THBS1	THBS1	THBS1	1460	0.31	0.48	YES
41	COL6A6	COL6A6	COL6A6	1486	0.31	0.49	YES
42	COL5A3	COL5A3	COL5A3	1590	0.3	0.49	YES
43	COL4A1	COL4A1	COL4A1	1802	0.28	0.49	YES
44	PRKCB	PRKCB	PRKCB	1909	0.27	0.49	YES
45	VEGFA	VEGFA	VEGFA	1922	0.26	0.5	YES
46	VAV1	VAV1	VAV1	1952	0.26	0.51	YES
47	RASGRF1	RASGRF1	RASGRF1	1978	0.26	0.51	YES
48	PAK3	PAK3	PAK3	2081	0.25	0.51	YES
49	PDGFB	PDGFB	PDGFB	2170	0.25	0.52	YES
50	ROCK2	ROCK2	ROCK2	2216	0.24	0.52	YES
51	MYLK2	MYLK2	MYLK2	2332	0.23	0.52	YES
52	BIRC3	BIRC3	BIRC3	2414	0.23	0.52	YES
53	MAPK8	MAPK8	MAPK8	2503	0.22	0.53	YES
54	LAMA3	LAMA3	LAMA3	2527	0.22	0.53	YES
55	PGF	PGF	PGF	2613	0.21	0.53	YES
56	CCND1	CCND1	CCND1	2662	0.21	0.54	YES
57	ITGA5	ITGA5	ITGA5	2685	0.21	0.54	YES
58	COL4A6	COL4A6	COL4A6	2724	0.21	0.55	YES
59	MYLK	MYLK	MYLK	2735	0.21	0.55	YES
60	RAC2	RAC2	RAC2	2846	0.2	0.55	YES
61	VCL	VCL	VCL	2867	0.2	0.56	YES
62	VEGFC	VEGFC	VEGFC	2940	0.19	0.56	YES
63	PIK3CA	PIK3CA	PIK3CA	3044	0.19	0.56	YES
64	ITGB4	ITGB4	ITGB4	3092	0.18	0.56	YES
65	ITGAV	ITGAV	ITGAV	3137	0.18	0.56	YES
66	VWF	VWF	VWF	3141	0.18	0.57	YES
67	FLNA	FLNA	FLNA	3180	0.18	0.57	YES
68	ACTN1	ACTN1	ACTN1	3198	0.18	0.58	YES
69	COL4A2	COL4A2	COL4A2	3595	0.16	0.56	NO
70	COL4A4	COL4A4	COL4A4	3769	0.15	0.55	NO
71	ITGB1	ITGB1	ITGB1	3869	0.15	0.55	NO
72	ROCK1	ROCK1	ROCK1	3879	0.15	0.56	NO
73	PIK3R5	PIK3R5	PIK3R5	3956	0.14	0.56	NO
74	PDGFD	PDGFD	PDGFD	4199	0.13	0.55	NO
75	CAV1	CAV1	CAV1	4226	0.13	0.55	NO
76	EGFR	EGFR	EGFR	4399	0.13	0.54	NO
77	LAMC1	LAMC1	LAMC1	4484	0.12	0.54	NO
78	THBS4	THBS4	THBS4	4524	0.12	0.54	NO
79	THBS2	THBS2	THBS2	4610	0.12	0.54	NO
80	JUN	JUN	JUN	4720	0.12	0.54	NO
81	CCND3	CCND3	CCND3	4839	0.11	0.54	NO
82	DOCK1	DOCK1	DOCK1	4942	0.11	0.54	NO
83	FYN	FYN	FYN	5216	0.099	0.52	NO
84	COL6A1	COL6A1	COL6A1	5227	0.099	0.52	NO
85	ITGB5	ITGB5	ITGB5	5233	0.098	0.53	NO
86	MYL9	MYL9	MYL9	5299	0.097	0.53	NO
87	PTEN	PTEN	PTEN	5398	0.094	0.52	NO
88	SOS1	SOS1	SOS1	5404	0.094	0.53	NO
89	MAP2K1	MAP2K1	MAP2K1	5407	0.094	0.53	NO
90	BRAF	BRAF	BRAF	5446	0.092	0.53	NO
91	PPP1R12A	PPP1R12A	PPP1R12A	5487	0.091	0.53	NO
92	ARHGAP5	ARHGAP5	ARHGAP5	5517	0.09	0.53	NO
93	CRKL	CRKL	CRKL	5518	0.09	0.53	NO
94	VASP	VASP	VASP	5558	0.089	0.54	NO
95	CTNNB1	CTNNB1	CTNNB1	5708	0.086	0.53	NO
96	FIGF	FIGF	FIGF	5756	0.084	0.53	NO
97	AKT3	AKT3	AKT3	5768	0.084	0.53	NO
98	PARVA	PARVA	PARVA	5785	0.084	0.53	NO
99	PIK3CD	PIK3CD	PIK3CD	5819	0.083	0.53	NO
100	ELK1	ELK1	ELK1	5823	0.083	0.54	NO
101	SHC1	SHC1	SHC1	5967	0.079	0.53	NO
102	XIAP	XIAP	XIAP	5990	0.079	0.53	NO
103	ITGA3	ITGA3	ITGA3	6247	0.074	0.52	NO
104	ACTN2	ACTN2	ACTN2	6380	0.071	0.51	NO
105	RAP1A	RAP1A	RAP1A	6443	0.07	0.51	NO
106	CRK	CRK	CRK	6505	0.068	0.51	NO
107	IGF1R	IGF1R	IGF1R	6594	0.066	0.51	NO
108	PARVG	PARVG	PARVG	6625	0.066	0.51	NO
109	BIRC2	BIRC2	BIRC2	6870	0.06	0.5	NO
110	PTK2	PTK2	PTK2	7167	0.055	0.48	NO
111	LAMA5	LAMA5	LAMA5	7211	0.054	0.48	NO
112	RAPGEF1	RAPGEF1	RAPGEF1	7252	0.053	0.48	NO
113	MAPK1	MAPK1	MAPK1	7286	0.052	0.48	NO
114	TLN1	TLN1	TLN1	7455	0.049	0.47	NO
115	CDC42	CDC42	CDC42	7513	0.048	0.47	NO
116	SOS2	SOS2	SOS2	7514	0.048	0.47	NO
117	ACTN4	ACTN4	ACTN4	7531	0.048	0.47	NO
118	PIP5K1C	PIP5K1C	PIP5K1C	7627	0.046	0.47	NO
119	VAV2	VAV2	VAV2	7698	0.045	0.47	NO
120	MYL12A	MYL12A	MYL12A	7712	0.045	0.47	NO
121	PIK3R1	PIK3R1	PIK3R1	7744	0.044	0.47	NO
122	PAK2	PAK2	PAK2	7819	0.043	0.46	NO
123	GSK3B	GSK3B	GSK3B	7929	0.041	0.46	NO
124	AKT1	AKT1	AKT1	8012	0.04	0.46	NO
125	FLNB	FLNB	FLNB	8202	0.037	0.44	NO
126	COL11A2	COL11A2	COL11A2	8403	0.033	0.44	NO
127	PAK7	PAK7	PAK7	8407	0.033	0.44	NO
128	CAPN2	CAPN2	CAPN2	8458	0.032	0.43	NO
129	PPP1CB	PPP1CB	PPP1CB	8605	0.03	0.43	NO
130	PIK3CB	PIK3CB	PIK3CB	8701	0.028	0.42	NO
131	ERBB2	ERBB2	ERBB2	8805	0.027	0.42	NO
132	LAMB2	LAMB2	LAMB2	8813	0.027	0.42	NO
133	CCND2	CCND2	CCND2	8866	0.026	0.42	NO
134	ACTG1	ACTG1	ACTG1	8954	0.025	0.41	NO
135	PXN	PXN	PXN	8988	0.024	0.41	NO
136	PIK3R3	PIK3R3	PIK3R3	9002	0.024	0.41	NO
137	MAPK10	MAPK10	MAPK10	9218	0.02	0.4	NO
138	DIAPH1	DIAPH1	DIAPH1	9411	0.017	0.39	NO
139	COL2A1	COL2A1	COL2A1	9448	0.017	0.39	NO
140	RHOA	RHOA	RHOA	9523	0.016	0.38	NO
141	SRC	SRC	SRC	9601	0.014	0.38	NO
142	PDGFA	PDGFA	PDGFA	9608	0.014	0.38	NO
143	AKT2	AKT2	AKT2	9624	0.014	0.38	NO
144	ITGA7	ITGA7	ITGA7	9628	0.014	0.38	NO
145	ZYX	ZYX	ZYX	9643	0.014	0.38	NO
146	RAF1	RAF1	RAF1	9646	0.014	0.38	NO
147	ACTB	ACTB	ACTB	9732	0.012	0.38	NO
148	PDGFC	PDGFC	PDGFC	9869	0.01	0.37	NO
149	RAP1B	RAP1B	RAP1B	10049	0.0071	0.36	NO
150	SPP1	SPP1	SPP1	10406	0.001	0.34	NO
151	PDPK1	PDPK1	PDPK1	10415	0.00096	0.34	NO
152	BCL2	BCL2	BCL2	10423	0.00083	0.34	NO
153	PPP1CC	PPP1CC	PPP1CC	10490	-0.00054	0.33	NO
154	ITGA6	ITGA6	ITGA6	10573	-0.0016	0.33	NO
155	MET	MET	MET	10604	-0.0021	0.33	NO
156	MAPK3	MAPK3	MAPK3	10867	-0.0068	0.31	NO
157	MYL12B	MYL12B	MYL12B	11073	-0.01	0.3	NO
158	PAK1	PAK1	PAK1	11367	-0.015	0.28	NO
159	MAPK9	MAPK9	MAPK9	11373	-0.015	0.28	NO
160	ILK	ILK	ILK	11451	-0.016	0.28	NO
161	ITGA2B	ITGA2B	ITGA2B	11604	-0.019	0.27	NO
162	RAC1	RAC1	RAC1	11607	-0.019	0.27	NO
163	SHC2	SHC2	SHC2	11635	-0.019	0.27	NO
164	ACTN3	ACTN3	ACTN3	11707	-0.02	0.27	NO
165	PPP1CA	PPP1CA	PPP1CA	11786	-0.022	0.27	NO
166	LAMB1	LAMB1	LAMB1	11824	-0.022	0.26	NO
167	THBS3	THBS3	THBS3	11826	-0.023	0.26	NO
168	VAV3	VAV3	VAV3	11966	-0.025	0.26	NO
169	PIK3R2	PIK3R2	PIK3R2	12062	-0.027	0.25	NO
170	PRKCA	PRKCA	PRKCA	12074	-0.027	0.25	NO
171	PAK4	PAK4	PAK4	12118	-0.028	0.25	NO
172	LAMB4	LAMB4	LAMB4	12540	-0.036	0.23	NO
173	MYLPF	MYLPF	MYLPF	12671	-0.038	0.22	NO
174	HRAS	HRAS	HRAS	12706	-0.039	0.22	NO
175	CAV2	CAV2	CAV2	12727	-0.04	0.22	NO
176	ITGB8	ITGB8	ITGB8	12782	-0.041	0.22	NO
177	GRB2	GRB2	GRB2	13043	-0.046	0.21	NO
178	PARVB	PARVB	PARVB	13221	-0.05	0.2	NO
179	ITGB7	ITGB7	ITGB7	13893	-0.064	0.16	NO
180	BAD	BAD	BAD	13942	-0.065	0.16	NO
181	BCAR1	BCAR1	BCAR1	14755	-0.088	0.12	NO
182	VTN	VTN	VTN	14885	-0.091	0.12	NO
183	MYLK3	MYLK3	MYLK3	15079	-0.098	0.11	NO
184	TLN2	TLN2	TLN2	15136	-0.1	0.11	NO
185	VEGFB	VEGFB	VEGFB	15263	-0.1	0.1	NO
186	CHAD	CHAD	CHAD	15544	-0.11	0.091	NO
187	LAMA1	LAMA1	LAMA1	16177	-0.14	0.06	NO
188	RELN	RELN	RELN	16886	-0.19	0.026	NO
189	EGF	EGF	EGF	16931	-0.19	0.029	NO
190	PRKCG	PRKCG	PRKCG	16936	-0.19	0.035	NO
191	RAC3	RAC3	RAC3	17236	-0.23	0.025	NO
192	MYL5	MYL5	MYL5	17471	-0.27	0.02	NO
193	FLNC	FLNC	FLNC	17575	-0.29	0.023	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	TCF4	TCF4	TCF4	508	0.46	0.047	YES
2	TGFB1I1	TGFB1I1	TGFB1I1	845	0.39	0.093	YES
3	MAK	MAK	MAK	1558	0.3	0.1	YES
4	TMPRSS2	TMPRSS2	TMPRSS2	1941	0.26	0.12	YES
5	SNURF	SNURF	SNURF	2164	0.25	0.15	YES
6	FHL2	FHL2	FHL2	2187	0.24	0.19	YES
7	NCOA2	NCOA2	NCOA2	2489	0.22	0.21	YES
8	CCND1	CCND1	CCND1	2662	0.21	0.24	YES
9	HIP1	HIP1	HIP1	2842	0.2	0.26	YES
10	NKX3-1	NKX3-1	NKX3-1	2957	0.19	0.28	YES
11	GSN	GSN	GSN	3351	0.17	0.29	YES
12	CMTM2	CMTM2	CMTM2	3505	0.16	0.31	YES
13	PIAS3	PIAS3	PIAS3	3821	0.15	0.31	YES
14	SVIL	SVIL	SVIL	4148	0.14	0.32	YES
15	PIAS1	PIAS1	PIAS1	4266	0.13	0.33	YES
16	TMF1	TMF1	TMF1	4269	0.13	0.35	YES
17	PAWR	PAWR	PAWR	4297	0.13	0.37	YES
18	KDM4C	KDM4C	KDM4C	4573	0.12	0.38	YES
19	SRF	SRF	SRF	4824	0.11	0.38	YES
20	CCND3	CCND3	CCND3	4839	0.11	0.4	YES
21	NRIP1	NRIP1	NRIP1	4912	0.11	0.41	YES
22	CDKN2A	CDKN2A	CDKN2A	4933	0.11	0.43	YES
23	ZMIZ1	ZMIZ1	ZMIZ1	4974	0.11	0.44	YES
24	CTDSP2	CTDSP2	CTDSP2	5202	0.099	0.45	YES
25	PRKDC	PRKDC	PRKDC	5648	0.087	0.44	YES
26	CTNNB1	CTNNB1	CTNNB1	5708	0.086	0.45	YES
27	RANBP9	RANBP9	RANBP9	5740	0.085	0.46	YES
28	LATS2	LATS2	LATS2	5961	0.08	0.46	YES
29	PIAS4	PIAS4	PIAS4	6319	0.072	0.45	YES
30	ZNF318	ZNF318	ZNF318	6526	0.068	0.45	YES
31	APPL1	APPL1	APPL1	6621	0.066	0.46	YES
32	RPS6KA3	RPS6KA3	RPS6KA3	6634	0.066	0.47	YES
33	UBE3A	UBE3A	UBE3A	6768	0.063	0.47	YES
34	PTK2B	PTK2B	PTK2B	6777	0.062	0.48	YES
35	MED1	MED1	MED1	6801	0.062	0.49	YES
36	KDM1A	KDM1A	KDM1A	6871	0.06	0.5	YES
37	BRCA1	BRCA1	BRCA1	7109	0.056	0.49	YES
38	CDK6	CDK6	CDK6	7150	0.055	0.5	YES
39	XRCC5	XRCC5	XRCC5	7359	0.051	0.5	YES
40	KDM3A	KDM3A	KDM3A	7372	0.051	0.5	YES
41	AKT1	AKT1	AKT1	8012	0.04	0.47	NO
42	AR	AR	AR	8216	0.037	0.47	NO
43	TGIF1	TGIF1	TGIF1	8236	0.036	0.47	NO
44	KLK3	KLK3	KLK3	8774	0.027	0.45	NO
45	NCOA6	NCOA6	NCOA6	9068	0.023	0.44	NO
46	CTDSP1	CTDSP1	CTDSP1	9071	0.023	0.44	NO
47	PATZ1	PATZ1	PATZ1	9271	0.02	0.43	NO
48	XRCC6	XRCC6	XRCC6	9398	0.018	0.43	NO
49	HNRNPA1	HNRNPA1	HNRNPA1	9467	0.016	0.43	NO
50	NCOA4	NCOA4	NCOA4	10024	0.0075	0.4	NO
51	UBA3	UBA3	UBA3	10038	0.0074	0.4	NO
52	CDK11B	CDK11B	CDK11B	10180	0.0047	0.39	NO
53	CARM1	CARM1	CARM1	10270	0.0033	0.38	NO
54	CASP8	CASP8	CASP8	11193	-0.012	0.34	NO
55	UBE2I	UBE2I	UBE2I	11541	-0.018	0.32	NO
56	KLK2	KLK2	KLK2	11806	-0.022	0.31	NO
57	VAV3	VAV3	VAV3	11966	-0.025	0.3	NO
58	PA2G4	PA2G4	PA2G4	12400	-0.033	0.28	NO
59	PELP1	PELP1	PELP1	12565	-0.036	0.28	NO
60	PRDX1	PRDX1	PRDX1	13540	-0.056	0.24	NO
61	FKBP4	FKBP4	FKBP4	14184	-0.072	0.21	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	PDGFRA	PDGFRA	PDGFRA	20	0.76	0.2	YES
2	PIK3CG	PIK3CG	PIK3CG	308	0.52	0.32	YES
3	S1PR1	S1PR1	S1PR1	1167	0.34	0.36	YES
4	ITGB3	ITGB3	ITGB3	1356	0.32	0.44	YES
5	ADCY1	ADCY1	ADCY1	1561	0.3	0.5	YES
6	PLCB1	PLCB1	PLCB1	1593	0.29	0.58	YES
7	PRKCB	PRKCB	PRKCB	1909	0.27	0.63	YES
8	PIK3CA	PIK3CA	PIK3CA	3044	0.19	0.62	YES
9	ITGAV	ITGAV	ITGAV	3137	0.18	0.66	YES
10	GNAI1	GNAI1	GNAI1	6952	0.059	0.46	NO
11	GNB1	GNB1	GNB1	7020	0.057	0.47	NO
12	PTK2	PTK2	PTK2	7167	0.055	0.48	NO
13	MAPK1	MAPK1	MAPK1	7286	0.052	0.49	NO
14	PIK3R1	PIK3R1	PIK3R1	7744	0.044	0.47	NO
15	AKT1	AKT1	AKT1	8012	0.04	0.47	NO
16	RHOA	RHOA	RHOA	9523	0.016	0.39	NO
17	SRC	SRC	SRC	9601	0.014	0.39	NO
18	PDGFA	PDGFA	PDGFA	9608	0.014	0.39	NO
19	SPHK1	SPHK1	SPHK1	10239	0.0039	0.36	NO
20	MAPK3	MAPK3	MAPK3	10867	-0.0068	0.32	NO
21	ASAH1	ASAH1	ASAH1	11132	-0.011	0.31	NO
22	RAC1	RAC1	RAC1	11607	-0.019	0.29	NO
23	PRKCA	PRKCA	PRKCA	12074	-0.027	0.27	NO
24	SMPD2	SMPD2	SMPD2	13317	-0.052	0.22	NO
25	SMPD1	SMPD1	SMPD1	14413	-0.078	0.18	NO
26	GNGT1	GNGT1	GNGT1	14595	-0.083	0.19	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	CDKN2B	CDKN2B	CDKN2B	312	0.52	0.068	YES
2	SERPINE1	SERPINE1	SERPINE1	838	0.39	0.1	YES
3	PMEPA1	PMEPA1	PMEPA1	875	0.38	0.16	YES
4	SKIL	SKIL	SKIL	944	0.37	0.22	YES
5	CCNT1	CCNT1	CCNT1	1775	0.28	0.22	YES
6	JUNB	JUNB	JUNB	1945	0.26	0.26	YES
7	CGN	CGN	CGN	2077	0.25	0.29	YES
8	TGFB1	TGFB1	TGFB1	2461	0.22	0.3	YES
9	RBL1	RBL1	RBL1	2873	0.2	0.31	YES
10	TGFBR2	TGFBR2	TGFBR2	2889	0.2	0.34	YES
11	SKI	SKI	SKI	3539	0.16	0.34	YES
12	SMURF2	SMURF2	SMURF2	3553	0.16	0.36	YES
13	ZFYVE9	ZFYVE9	ZFYVE9	3843	0.15	0.37	YES
14	FURIN	FURIN	FURIN	4181	0.13	0.37	YES
15	WWTR1	WWTR1	WWTR1	4615	0.12	0.37	YES
16	TGFBR1	TGFBR1	TGFBR1	4669	0.12	0.38	YES
17	HDAC1	HDAC1	HDAC1	4871	0.11	0.39	YES
18	SMAD7	SMAD7	SMAD7	5098	0.1	0.4	YES
19	NCOR2	NCOR2	NCOR2	5278	0.097	0.4	YES
20	UBE2D1	UBE2D1	UBE2D1	5483	0.091	0.4	YES
21	TRIM33	TRIM33	TRIM33	5597	0.088	0.41	YES
22	TFDP1	TFDP1	TFDP1	6022	0.078	0.4	YES
23	UCHL5	UCHL5	UCHL5	6136	0.076	0.41	YES
24	USP9X	USP9X	USP9X	6146	0.076	0.42	YES
25	PPP1R15A	PPP1R15A	PPP1R15A	6201	0.075	0.43	YES
26	SMAD3	SMAD3	SMAD3	6276	0.073	0.44	YES
27	F11R	F11R	F11R	6299	0.073	0.45	YES
28	PARP1	PARP1	PARP1	6373	0.071	0.46	YES
29	NCOR1	NCOR1	NCOR1	6379	0.071	0.47	YES
30	SMAD2	SMAD2	SMAD2	6463	0.069	0.47	YES
31	CCNT2	CCNT2	CCNT2	6499	0.068	0.48	YES
32	CDK8	CDK8	CDK8	6649	0.065	0.48	YES
33	E2F5	E2F5	E2F5	7014	0.058	0.48	NO
34	SMURF1	SMURF1	SMURF1	7208	0.054	0.47	NO
35	TGIF2	TGIF2	TGIF2	7619	0.046	0.46	NO
36	SMAD4	SMAD4	SMAD4	8086	0.039	0.44	NO
37	TGIF1	TGIF1	TGIF1	8236	0.036	0.44	NO
38	PARD3	PARD3	PARD3	8327	0.035	0.44	NO
39	PPP1CB	PPP1CB	PPP1CB	8605	0.03	0.43	NO
40	UBE2D3	UBE2D3	UBE2D3	8646	0.029	0.43	NO
41	CCNC	CCNC	CCNC	8687	0.029	0.43	NO
42	MYC	MYC	MYC	8752	0.028	0.43	NO
43	ARHGEF18	ARHGEF18	ARHGEF18	9473	0.016	0.39	NO
44	RHOA	RHOA	RHOA	9523	0.016	0.39	NO
45	PPM1A	PPM1A	PPM1A	10147	0.0053	0.36	NO
46	SP1	SP1	SP1	10235	0.0039	0.36	NO
47	RPS27A	RPS27A	RPS27A	10303	0.0027	0.35	NO
48	PPP1CC	PPP1CC	PPP1CC	10490	-0.00054	0.34	NO
49	XPO1	XPO1	XPO1	10563	-0.0014	0.34	NO
50	FKBP1A	FKBP1A	FKBP1A	11032	-0.0095	0.31	NO
51	PRKCZ	PRKCZ	PRKCZ	11235	-0.012	0.3	NO
52	STRAP	STRAP	STRAP	11583	-0.018	0.29	NO
53	UBA52	UBA52	UBA52	11621	-0.019	0.29	NO
54	PPP1CA	PPP1CA	PPP1CA	11786	-0.022	0.28	NO
55	CDK9	CDK9	CDK9	11914	-0.024	0.28	NO
56	MEN1	MEN1	MEN1	12032	-0.026	0.28	NO
57	MTMR4	MTMR4	MTMR4	12402	-0.033	0.26	NO
58	E2F4	E2F4	E2F4	12714	-0.04	0.25	NO
59	PARD6A	PARD6A	PARD6A	15830	-0.12	0.099	NO
60	STUB1	STUB1	STUB1	15898	-0.13	0.12	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	CNTN1	CNTN1	CNTN1	4	0.83	0.067	YES
2	NOTCH3	NOTCH3	NOTCH3	366	0.5	0.087	YES
3	HEYL	HEYL	HEYL	520	0.46	0.12	YES
4	DLL1	DLL1	DLL1	662	0.42	0.14	YES
5	EIF2C2	EIF2C2	EIF2C2	1017	0.36	0.15	YES
6	DLL4	DLL4	DLL4	1061	0.36	0.18	YES
7	MAML2	MAML2	MAML2	1207	0.34	0.2	YES
8	HEY1	HEY1	HEY1	1274	0.33	0.22	YES
9	ATP2A3	ATP2A3	ATP2A3	1412	0.32	0.24	YES
10	NOTCH4	NOTCH4	NOTCH4	1539	0.3	0.26	YES
11	HEY2	HEY2	HEY2	1646	0.29	0.27	YES
12	MAML3	MAML3	MAML3	1668	0.29	0.3	YES
13	DTX1	DTX1	DTX1	1965	0.26	0.3	YES
14	NEURL	NEURL	NEURL	2025	0.26	0.32	YES
15	CCND1	CCND1	CCND1	2662	0.21	0.3	YES
16	ADAM10	ADAM10	ADAM10	2955	0.19	0.3	YES
17	HES1	HES1	HES1	3094	0.18	0.31	YES
18	MFNG	MFNG	MFNG	3262	0.17	0.31	YES
19	ADAM17	ADAM17	ADAM17	3469	0.16	0.31	YES
20	JAG2	JAG2	JAG2	3546	0.16	0.32	YES
21	JAG1	JAG1	JAG1	3575	0.16	0.33	YES
22	HES5	HES5	HES5	3705	0.15	0.34	YES
23	MIB1	MIB1	MIB1	3756	0.15	0.35	YES
24	MAMLD1	MAMLD1	MAMLD1	3792	0.15	0.36	YES
25	EIF2C4	EIF2C4	EIF2C4	3793	0.15	0.37	YES
26	HDAC4	HDAC4	HDAC4	3905	0.14	0.38	YES
27	ARRB1	ARRB1	ARRB1	3948	0.14	0.39	YES
28	NOTCH2	NOTCH2	NOTCH2	3951	0.14	0.4	YES
29	TLE2	TLE2	TLE2	3990	0.14	0.41	YES
30	EP300	EP300	EP300	4158	0.14	0.41	YES
31	FURIN	FURIN	FURIN	4181	0.13	0.42	YES
32	TLE3	TLE3	TLE3	4284	0.13	0.42	YES
33	FBXW7	FBXW7	FBXW7	4296	0.13	0.43	YES
34	EIF2C3	EIF2C3	EIF2C3	4363	0.13	0.44	YES
35	HIF1A	HIF1A	HIF1A	4370	0.13	0.45	YES
36	SEL1L	SEL1L	SEL1L	4647	0.12	0.44	YES
37	JUN	JUN	JUN	4720	0.12	0.45	YES
38	HDAC1	HDAC1	HDAC1	4871	0.11	0.45	YES
39	MAML1	MAML1	MAML1	4880	0.11	0.46	YES
40	KAT2B	KAT2B	KAT2B	4885	0.11	0.47	YES
41	HDAC9	HDAC9	HDAC9	5126	0.1	0.46	YES
42	APH1B	APH1B	APH1B	5214	0.099	0.46	YES
43	NCOR2	NCOR2	NCOR2	5278	0.097	0.47	YES
44	DTX4	DTX4	DTX4	5516	0.09	0.46	NO
45	TLE4	TLE4	TLE4	5713	0.085	0.46	NO
46	HDAC2	HDAC2	HDAC2	5907	0.081	0.45	NO
47	TFDP1	TFDP1	TFDP1	6022	0.078	0.45	NO
48	B4GALT1	B4GALT1	B4GALT1	6151	0.076	0.45	NO
49	TNRC6B	TNRC6B	TNRC6B	6279	0.073	0.45	NO
50	TNRC6C	TNRC6C	TNRC6C	6290	0.073	0.46	NO
51	NCOR1	NCOR1	NCOR1	6379	0.071	0.46	NO
52	RAB6A	RAB6A	RAB6A	6632	0.066	0.45	NO
53	CDK8	CDK8	CDK8	6649	0.065	0.45	NO
54	EIF2C1	EIF2C1	EIF2C1	6928	0.059	0.44	NO
55	NCSTN	NCSTN	NCSTN	7098	0.056	0.44	NO
56	HDAC7	HDAC7	HDAC7	7254	0.053	0.43	NO
57	E2F3	E2F3	E2F3	7340	0.052	0.43	NO
58	SNW1	SNW1	SNW1	7431	0.05	0.43	NO
59	RBPJ	RBPJ	RBPJ	7466	0.049	0.44	NO
60	CREBBP	CREBBP	CREBBP	7530	0.048	0.44	NO
61	TBL1X	TBL1X	TBL1X	7532	0.048	0.44	NO
62	TBL1XR1	TBL1XR1	TBL1XR1	7694	0.045	0.43	NO
63	ATP2A2	ATP2A2	ATP2A2	7954	0.041	0.42	NO
64	TMED2	TMED2	TMED2	7958	0.041	0.43	NO
65	CUL1	CUL1	CUL1	8271	0.036	0.41	NO
66	TLE1	TLE1	TLE1	8607	0.03	0.4	NO
67	CCNC	CCNC	CCNC	8687	0.029	0.39	NO
68	MYC	MYC	MYC	8752	0.028	0.39	NO
69	PSEN1	PSEN1	PSEN1	8850	0.026	0.39	NO
70	DTX2	DTX2	DTX2	8957	0.025	0.38	NO
71	TP53	TP53	TP53	9629	0.014	0.35	NO
72	APH1A	APH1A	APH1A	9856	0.01	0.34	NO
73	DNER	DNER	DNER	10115	0.006	0.32	NO
74	RPS27A	RPS27A	RPS27A	10303	0.0027	0.31	NO
75	POFUT1	POFUT1	POFUT1	10339	0.002	0.31	NO
76	SKP1	SKP1	SKP1	10565	-0.0014	0.3	NO
77	RBX1	RBX1	RBX1	10746	-0.0046	0.29	NO
78	HDAC3	HDAC3	HDAC3	11055	-0.0098	0.27	NO
79	PSEN2	PSEN2	PSEN2	11247	-0.013	0.26	NO
80	HDAC5	HDAC5	HDAC5	11427	-0.016	0.25	NO
81	E2F1	E2F1	E2F1	11598	-0.019	0.24	NO
82	UBA52	UBA52	UBA52	11621	-0.019	0.24	NO
83	NUMB	NUMB	NUMB	11839	-0.023	0.24	NO
84	MIB2	MIB2	MIB2	11916	-0.024	0.23	NO
85	LFNG	LFNG	LFNG	11942	-0.025	0.23	NO
86	ARRB2	ARRB2	ARRB2	12408	-0.034	0.21	NO
87	MOV10	MOV10	MOV10	12430	-0.034	0.21	NO
88	ST3GAL6	ST3GAL6	ST3GAL6	12839	-0.042	0.19	NO
89	TNRC6A	TNRC6A	TNRC6A	13222	-0.05	0.18	NO
90	HDAC8	HDAC8	HDAC8	13460	-0.054	0.17	NO
91	ST3GAL3	ST3GAL3	ST3GAL3	13603	-0.057	0.16	NO
92	PSENEN	PSENEN	PSENEN	14134	-0.07	0.14	NO
93	HDAC6	HDAC6	HDAC6	14241	-0.073	0.14	NO
94	HDAC11	HDAC11	HDAC11	15275	-0.1	0.09	NO
95	HDAC10	HDAC10	HDAC10	15560	-0.11	0.083	NO
96	RFNG	RFNG	RFNG	15997	-0.13	0.069	NO
97	KAT2A	KAT2A	KAT2A	16176	-0.14	0.071	NO
98	ATP2A1	ATP2A1	ATP2A1	17795	-0.37	0.01	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	SFRP1	SFRP1	SFRP1	2	0.89	0.044	YES
2	LEF1	LEF1	LEF1	73	0.67	0.074	YES
3	FZD10	FZD10	FZD10	96	0.65	0.1	YES
4	NKD1	NKD1	NKD1	170	0.59	0.13	YES
5	WNT10A	WNT10A	WNT10A	213	0.57	0.16	YES
6	WNT4	WNT4	WNT4	236	0.55	0.18	YES
7	DAAM2	DAAM2	DAAM2	245	0.55	0.21	YES
8	DKK1	DKK1	DKK1	249	0.55	0.24	YES
9	NFATC2	NFATC2	NFATC2	352	0.5	0.26	YES
10	SFRP2	SFRP2	SFRP2	371	0.5	0.28	YES
11	WNT7A	WNT7A	WNT7A	654	0.42	0.28	YES
12	WNT9B	WNT9B	WNT9B	710	0.41	0.3	YES
13	DKK2	DKK2	DKK2	713	0.41	0.32	YES
14	WNT9A	WNT9A	WNT9A	844	0.39	0.33	YES
15	NFATC4	NFATC4	NFATC4	884	0.38	0.35	YES
16	FZD7	FZD7	FZD7	894	0.38	0.37	YES
17	SOX17	SOX17	SOX17	927	0.38	0.39	YES
18	CAMK2A	CAMK2A	CAMK2A	1005	0.36	0.4	YES
19	FOSL1	FOSL1	FOSL1	1105	0.35	0.41	YES
20	WNT6	WNT6	WNT6	1278	0.33	0.42	YES
21	TCF7	TCF7	TCF7	1311	0.32	0.43	YES
22	DAAM1	DAAM1	DAAM1	1537	0.3	0.44	YES
23	PLCB1	PLCB1	PLCB1	1593	0.29	0.45	YES
24	TCF7L1	TCF7L1	TCF7L1	1727	0.28	0.45	YES
25	WNT7B	WNT7B	WNT7B	1898	0.27	0.46	YES
26	PRKCB	PRKCB	PRKCB	1909	0.27	0.47	YES
27	WNT8B	WNT8B	WNT8B	1967	0.26	0.48	YES
28	SFRP4	SFRP4	SFRP4	2099	0.25	0.48	YES
29	ROCK2	ROCK2	ROCK2	2216	0.24	0.49	YES
30	MAPK8	MAPK8	MAPK8	2503	0.22	0.48	YES
31	CCND1	CCND1	CCND1	2662	0.21	0.49	YES
32	CXXC4	CXXC4	CXXC4	2698	0.21	0.5	YES
33	RAC2	RAC2	RAC2	2846	0.2	0.5	YES
34	FZD3	FZD3	FZD3	3445	0.16	0.47	YES
35	PPP2R5E	PPP2R5E	PPP2R5E	3467	0.16	0.48	YES
36	MMP7	MMP7	MMP7	3694	0.15	0.47	YES
37	ROCK1	ROCK1	ROCK1	3879	0.15	0.47	YES
38	PPARD	PPARD	PPARD	3924	0.14	0.48	YES
39	WNT3A	WNT3A	WNT3A	4083	0.14	0.47	YES
40	EP300	EP300	EP300	4158	0.14	0.48	YES
41	NKD2	NKD2	NKD2	4189	0.13	0.48	YES
42	PLCB2	PLCB2	PLCB2	4190	0.13	0.49	YES
43	WNT1	WNT1	WNT1	4332	0.13	0.49	YES
44	FZD6	FZD6	FZD6	4407	0.13	0.49	YES
45	WNT2	WNT2	WNT2	4437	0.12	0.49	YES
46	VANGL2	VANGL2	VANGL2	4665	0.12	0.48	YES
47	WNT16	WNT16	WNT16	4689	0.12	0.49	YES
48	CHP2	CHP2	CHP2	4706	0.12	0.5	YES
49	JUN	JUN	JUN	4720	0.12	0.5	YES
50	PORCN	PORCN	PORCN	4781	0.11	0.5	YES
51	CCND3	CCND3	CCND3	4839	0.11	0.5	YES
52	NFATC1	NFATC1	NFATC1	4971	0.11	0.5	YES
53	TCF7L2	TCF7L2	TCF7L2	5069	0.1	0.5	YES
54	PRKX	PRKX	PRKX	5136	0.1	0.5	YES
55	CSNK1E	CSNK1E	CSNK1E	5153	0.1	0.51	YES
56	PPP2R5C	PPP2R5C	PPP2R5C	5476	0.092	0.49	NO
57	VANGL1	VANGL1	VANGL1	5631	0.087	0.49	NO
58	CSNK1A1L	CSNK1A1L	CSNK1A1L	5660	0.087	0.49	NO
59	CTNNB1	CTNNB1	CTNNB1	5708	0.086	0.49	NO
60	PRICKLE1	PRICKLE1	PRICKLE1	5804	0.083	0.49	NO
61	CHD8	CHD8	CHD8	5809	0.083	0.5	NO
62	PPP3CC	PPP3CC	PPP3CC	5854	0.082	0.5	NO
63	PPP3CB	PPP3CB	PPP3CB	6066	0.077	0.49	NO
64	SMAD3	SMAD3	SMAD3	6276	0.073	0.48	NO
65	PPP3R1	PPP3R1	PPP3R1	6399	0.071	0.48	NO
66	SMAD2	SMAD2	SMAD2	6463	0.069	0.48	NO
67	PPP3CA	PPP3CA	PPP3CA	6749	0.063	0.47	NO
68	MAP3K7	MAP3K7	MAP3K7	6796	0.062	0.47	NO
69	CTBP2	CTBP2	CTBP2	6826	0.061	0.47	NO
70	CER1	CER1	CER1	6833	0.061	0.47	NO
71	PPP2R1B	PPP2R1B	PPP2R1B	6852	0.061	0.47	NO
72	APC	APC	APC	6873	0.06	0.47	NO
73	NFATC3	NFATC3	NFATC3	6993	0.058	0.47	NO
74	SENP2	SENP2	SENP2	7114	0.056	0.47	NO
75	AXIN2	AXIN2	AXIN2	7142	0.055	0.47	NO
76	PPP2R5A	PPP2R5A	PPP2R5A	7194	0.054	0.47	NO
77	LRP5	LRP5	LRP5	7275	0.053	0.47	NO
78	PRKACB	PRKACB	PRKACB	7384	0.051	0.46	NO
79	CSNK1A1	CSNK1A1	CSNK1A1	7462	0.049	0.46	NO
80	WNT10B	WNT10B	WNT10B	7490	0.049	0.46	NO
81	CREBBP	CREBBP	CREBBP	7530	0.048	0.46	NO
82	TBL1X	TBL1X	TBL1X	7532	0.048	0.46	NO
83	FBXW11	FBXW11	FBXW11	7600	0.047	0.46	NO
84	TBL1XR1	TBL1XR1	TBL1XR1	7694	0.045	0.46	NO
85	GSK3B	GSK3B	GSK3B	7929	0.041	0.45	NO
86	BTRC	BTRC	BTRC	7959	0.041	0.45	NO
87	SFRP5	SFRP5	SFRP5	7993	0.04	0.45	NO
88	SMAD4	SMAD4	SMAD4	8086	0.039	0.45	NO
89	LRP6	LRP6	LRP6	8245	0.036	0.44	NO
90	CUL1	CUL1	CUL1	8271	0.036	0.44	NO
91	CTNNBIP1	CTNNBIP1	CTNNBIP1	8390	0.034	0.43	NO
92	NFAT5	NFAT5	NFAT5	8524	0.031	0.43	NO
93	DVL1	DVL1	DVL1	8606	0.03	0.42	NO
94	PLCB3	PLCB3	PLCB3	8713	0.028	0.42	NO
95	FRAT1	FRAT1	FRAT1	8725	0.028	0.42	NO
96	MYC	MYC	MYC	8752	0.028	0.42	NO
97	PSEN1	PSEN1	PSEN1	8850	0.026	0.42	NO
98	CCND2	CCND2	CCND2	8866	0.026	0.42	NO
99	CSNK2A1	CSNK2A1	CSNK2A1	8891	0.025	0.42	NO
100	SIAH1	SIAH1	SIAH1	8936	0.025	0.42	NO
101	PRKACA	PRKACA	PRKACA	8984	0.024	0.42	NO
102	MAPK10	MAPK10	MAPK10	9218	0.02	0.4	NO
103	RHOA	RHOA	RHOA	9523	0.016	0.39	NO
104	DVL3	DVL3	DVL3	9533	0.015	0.39	NO
105	FZD8	FZD8	FZD8	9581	0.014	0.38	NO
106	TP53	TP53	TP53	9629	0.014	0.38	NO
107	PLCB4	PLCB4	PLCB4	9704	0.013	0.38	NO
108	PPP2R5B	PPP2R5B	PPP2R5B	9804	0.011	0.37	NO
109	PPP2R5D	PPP2R5D	PPP2R5D	9957	0.0086	0.37	NO
110	CAMK2D	CAMK2D	CAMK2D	10117	0.006	0.36	NO
111	CAMK2G	CAMK2G	CAMK2G	10465	-0.000041	0.34	NO
112	PRICKLE2	PRICKLE2	PRICKLE2	10496	-0.00061	0.34	NO
113	SKP1	SKP1	SKP1	10565	-0.0014	0.33	NO
114	RBX1	RBX1	RBX1	10746	-0.0046	0.32	NO
115	FZD2	FZD2	FZD2	10951	-0.0082	0.31	NO
116	PPP2CA	PPP2CA	PPP2CA	10981	-0.0088	0.31	NO
117	WNT5B	WNT5B	WNT5B	11042	-0.0096	0.31	NO
118	FZD4	FZD4	FZD4	11051	-0.0098	0.31	NO
119	WNT3	WNT3	WNT3	11076	-0.01	0.31	NO
120	PPP2CB	PPP2CB	PPP2CB	11155	-0.011	0.3	NO
121	FRAT2	FRAT2	FRAT2	11189	-0.012	0.3	NO
122	PPP2R1A	PPP2R1A	PPP2R1A	11221	-0.012	0.3	NO
123	MAPK9	MAPK9	MAPK9	11373	-0.015	0.29	NO
124	RAC1	RAC1	RAC1	11607	-0.019	0.28	NO
125	FZD5	FZD5	FZD5	11681	-0.02	0.28	NO
126	FZD9	FZD9	FZD9	11988	-0.026	0.26	NO
127	PRKCA	PRKCA	PRKCA	12074	-0.027	0.26	NO
128	CTBP1	CTBP1	CTBP1	12192	-0.03	0.25	NO
129	CACYBP	CACYBP	CACYBP	12195	-0.03	0.26	NO
130	CSNK2B	CSNK2B	CSNK2B	12248	-0.031	0.25	NO
131	NLK	NLK	NLK	12290	-0.031	0.25	NO
132	RUVBL1	RUVBL1	RUVBL1	12726	-0.04	0.23	NO
133	DVL2	DVL2	DVL2	12897	-0.043	0.22	NO
134	CHP	CHP	CHP	12924	-0.044	0.22	NO
135	FZD1	FZD1	FZD1	13052	-0.046	0.22	NO
136	AXIN1	AXIN1	AXIN1	13270	-0.05	0.21	NO
137	WIF1	WIF1	WIF1	14344	-0.076	0.15	NO
138	CSNK2A2	CSNK2A2	CSNK2A2	14427	-0.078	0.15	NO
139	WNT5A	WNT5A	WNT5A	14514	-0.081	0.15	NO
140	WNT11	WNT11	WNT11	14618	-0.084	0.15	NO
141	WNT2B	WNT2B	WNT2B	14946	-0.093	0.14	NO
142	APC2	APC2	APC2	15344	-0.11	0.12	NO
143	CAMK2B	CAMK2B	CAMK2B	16523	-0.16	0.061	NO
144	PRKCG	PRKCG	PRKCG	16936	-0.19	0.047	NO
145	RAC3	RAC3	RAC3	17236	-0.23	0.042	NO

Fold change

For the top enriched genes, if you want to check whether they are

up-regulated, please check the list of up-regulated genes
down-regulated, please check the list of down-regulated genes

Expression level

For the top enriched genes, if you want to check whether they are

highly expressed genes, please check the list of high (top 30%) expressed genes
low expressed genes, please check the list of low (bottom 30%) expressed genes

An expression pattern of top(30%)/middle(30%)/low(30%) in this subtype against other subtypes is available in a heatmap

Significant gene list

For the top enriched genes, if you want to check whether they are

significantly differently expressed genes by eBayes lm fit, please check the list of significant genes

+ Subtype clus5 enriched pathways

Table 7. Get Full Table This table shows top 10 pathways which are significantly enriched in cluster clus5. It displays only significant gene sets satisfying nom.p.val.threshold (-1), fwer.p.val.threshold (-1) , fdr.q.val.threshold (0.25) and the default table is sorted by Normalized Enrichment Score (NES). Further details on NES statistics, please visit The Broad GSEA website.

GeneSet(GS)	Size(#genes)	genes.ES.table	ES	NES	NOM.p.val	FDR.q.val	FWER.p.val	Tag..	Gene..	Signal	FDR..median.	glob.p.val
KEGG OOCYTE MEIOSIS	106	genes.ES.table	0.5	1.7	0.016	1	0.78	0.27	0.14	0.24	0.56	0.34
KEGG UBIQUITIN MEDIATED PROTEOLYSIS	134	genes.ES.table	0.29	1.6	0.051	0.78	0.88	0.35	0.31	0.24	0.44	0.25
KEGG ADHERENS JUNCTION	73	genes.ES.table	0.44	1.6	0.025	1	0.84	0.19	0.13	0.17	0.59	0.34
KEGG THYROID CANCER	29	genes.ES.table	0.61	1.8	0.0021	1	0.49	0.24	0.13	0.21	0	0.44
BIOCARTA MPR PATHWAY	33	genes.ES.table	0.56	1.8	0.0021	1	0.58	0.21	0.083	0.2	0.59	0.38
BIOCARTA VEGF PATHWAY	29	genes.ES.table	0.56	1.6	0.053	0.77	0.88	0.34	0.19	0.28	0.45	0.25
PID AURORA B PATHWAY	39	genes.ES.table	0.71	1.6	0.034	1	0.86	0.51	0.14	0.44	0.61	0.34
PID DELTANP63PATHWAY	46	genes.ES.table	0.64	1.7	0.01	1	0.76	0.37	0.17	0.31	0.6	0.35
PID AURORA A PATHWAY	31	genes.ES.table	0.6	1.6	0.057	1	0.86	0.23	0.052	0.22	0.57	0.32
REACTOME CELL CYCLE	372	genes.ES.table	0.48	1.6	0.079	0.96	0.86	0.38	0.25	0.29	0.54	0.31

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	RET	RET	RET	356	0.37	0.13	YES
2	TCF7L1	TCF7L1	TCF7L1	456	0.35	0.26	YES
3	LEF1	LEF1	LEF1	497	0.34	0.39	YES
4	CDH1	CDH1	CDH1	1079	0.25	0.46	YES
5	RXRG	RXRG	RXRG	1264	0.23	0.54	YES
6	MYC	MYC	MYC	1922	0.18	0.57	YES
7	RXRA	RXRA	RXRA	2313	0.15	0.61	YES
8	CCND1	CCND1	CCND1	3678	0.094	0.57	NO
9	MAP2K1	MAP2K1	MAP2K1	4493	0.074	0.55	NO
10	BRAF	BRAF	BRAF	4896	0.066	0.56	NO
11	MAP2K2	MAP2K2	MAP2K2	5285	0.058	0.56	NO
12	TPR	TPR	TPR	5602	0.053	0.56	NO
13	CCDC6	CCDC6	CCDC6	7515	0.024	0.46	NO
14	NTRK1	NTRK1	NTRK1	8324	0.014	0.42	NO
15	NRAS	NRAS	NRAS	8337	0.014	0.43	NO
16	MAPK3	MAPK3	MAPK3	8769	0.0075	0.41	NO
17	TPM3	TPM3	TPM3	8888	0.006	0.4	NO
18	NCOA4	NCOA4	NCOA4	9430	-0.0015	0.37	NO
19	TP53	TP53	TP53	9503	-0.0025	0.37	NO
20	PPARG	PPARG	PPARG	9565	-0.0034	0.37	NO
21	TFG	TFG	TFG	9824	-0.0068	0.36	NO
22	TCF7L2	TCF7L2	TCF7L2	9898	-0.0079	0.36	NO
23	KRAS	KRAS	KRAS	10253	-0.014	0.34	NO
24	TCF7	TCF7	TCF7	10558	-0.018	0.33	NO
25	MAPK1	MAPK1	MAPK1	10625	-0.019	0.33	NO
26	RXRB	RXRB	RXRB	10629	-0.019	0.34	NO
27	HRAS	HRAS	HRAS	10648	-0.019	0.35	NO
28	CTNNB1	CTNNB1	CTNNB1	11801	-0.037	0.3	NO
29	PAX8	PAX8	PAX8	14948	-0.12	0.17	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	ADCY1	ADCY1	ADCY1	138	0.45	0.12	YES
2	CDC25C	CDC25C	CDC25C	160	0.44	0.24	YES
3	CDK1	CDK1	CDK1	434	0.35	0.32	YES
4	CCNB1	CCNB1	CCNB1	656	0.31	0.39	YES
5	PGR	PGR	PGR	701	0.3	0.47	YES
6	MYT1	MYT1	MYT1	848	0.28	0.54	YES
7	PRKAR2B	PRKAR2B	PRKAR2B	1488	0.21	0.56	YES
8	ACTR3	ACTR3	ACTR3	5420	0.056	0.36	NO
9	ACTR2	ACTR2	ACTR2	5913	0.048	0.35	NO
10	PRKAR2A	PRKAR2A	PRKAR2A	6327	0.041	0.34	NO
11	ARPC2	ARPC2	ARPC2	6391	0.04	0.34	NO
12	GNAS	GNAS	GNAS	6686	0.036	0.34	NO
13	PIN1	PIN1	PIN1	6840	0.034	0.34	NO
14	PRKAR1A	PRKAR1A	PRKAR1A	7424	0.026	0.31	NO
15	ARPC5	ARPC5	ARPC5	7730	0.021	0.3	NO
16	ARPC3	ARPC3	ARPC3	8410	0.012	0.27	NO
17	ARPC1A	ARPC1A	ARPC1A	8720	0.0081	0.25	NO
18	MAPK3	MAPK3	MAPK3	8769	0.0075	0.25	NO
19	SRC	SRC	SRC	9533	-0.0029	0.21	NO
20	PAQR5	PAQR5	PAQR5	10214	-0.013	0.18	NO
21	CAP1	CAP1	CAP1	10355	-0.015	0.17	NO
22	MAPK1	MAPK1	MAPK1	10625	-0.019	0.16	NO
23	HRAS	HRAS	HRAS	10648	-0.019	0.17	NO
24	PRKAR1B	PRKAR1B	PRKAR1B	11445	-0.032	0.13	NO
25	GNB1	GNB1	GNB1	11959	-0.04	0.11	NO
26	ARPC4	ARPC4	ARPC4	12446	-0.049	0.099	NO
27	ACTA1	ACTA1	ACTA1	13103	-0.063	0.08	NO
28	PAQR7	PAQR7	PAQR7	13828	-0.08	0.062	NO
29	ARPC1B	ARPC1B	ARPC1B	14428	-0.099	0.056	NO
30	PRKACB	PRKACB	PRKACB	14642	-0.11	0.073	NO
31	RPS6KA1	RPS6KA1	RPS6KA1	14842	-0.11	0.093	NO
32	GNAI1	GNAI1	GNAI1	15154	-0.13	0.11	NO
33	GNGT1	GNGT1	GNGT1	16000	-0.17	0.11	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	RQCD1	RQCD1	RQCD1	2146	0.16	-0.034	YES
2	DCPS	DCPS	DCPS	2482	0.14	0.022	YES
3	PABPC1	PABPC1	PABPC1	2876	0.12	0.065	YES
4	EIF4E	EIF4E	EIF4E	3192	0.11	0.11	YES
5	EXOSC5	EXOSC5	EXOSC5	3490	0.099	0.14	YES
6	PATL1	PATL1	PATL1	3600	0.096	0.19	YES
7	EIF4B	EIF4B	EIF4B	4298	0.078	0.19	YES
8	CNOT8	CNOT8	CNOT8	4735	0.069	0.2	YES
9	PAIP1	PAIP1	PAIP1	4833	0.067	0.23	YES
10	TNKS1BP1	TNKS1BP1	TNKS1BP1	5058	0.062	0.26	YES
11	EDC3	EDC3	EDC3	5548	0.054	0.26	YES
12	EXOSC4	EXOSC4	EXOSC4	5966	0.047	0.26	YES
13	EXOSC9	EXOSC9	EXOSC9	6009	0.047	0.28	YES
14	EXOSC7	EXOSC7	EXOSC7	6309	0.042	0.29	YES
15	EXOSC1	EXOSC1	EXOSC1	6510	0.038	0.3	YES
16	LSM1	LSM1	LSM1	6559	0.038	0.31	YES
17	EXOSC3	EXOSC3	EXOSC3	6773	0.034	0.32	YES
18	LSM6	LSM6	LSM6	6839	0.034	0.34	YES
19	EXOSC2	EXOSC2	EXOSC2	6896	0.033	0.35	YES
20	CNOT7	CNOT7	CNOT7	6913	0.032	0.37	YES
21	LSM2	LSM2	LSM2	6988	0.031	0.38	YES
22	EIF4A2	EIF4A2	EIF4A2	7058	0.03	0.39	YES
23	CNOT6	CNOT6	CNOT6	7176	0.029	0.4	YES
24	EXOSC6	EXOSC6	EXOSC6	7388	0.026	0.4	YES
25	C2orf29	C2orf29	C2orf29	7587	0.023	0.4	YES
26	EIF4A3	EIF4A3	EIF4A3	8252	0.015	0.37	NO
27	DCP1B	DCP1B	DCP1B	8375	0.013	0.38	NO
28	LSM4	LSM4	LSM4	8687	0.0085	0.36	NO
29	DIS3	DIS3	DIS3	8793	0.0072	0.36	NO
30	CNOT3	CNOT3	CNOT3	8933	0.0054	0.36	NO
31	PARN	PARN	PARN	8949	0.0051	0.36	NO
32	CNOT2	CNOT2	CNOT2	8996	0.0045	0.36	NO
33	CNOT10	CNOT10	CNOT10	9137	0.0028	0.35	NO
34	DDX6	DDX6	DDX6	9182	0.0021	0.35	NO
35	DCP2	DCP2	DCP2	9423	-0.0014	0.34	NO
36	EIF4G1	EIF4G1	EIF4G1	9447	-0.0018	0.34	NO
37	XRN1	XRN1	XRN1	9621	-0.004	0.33	NO
38	EIF4A1	EIF4A1	EIF4A1	10110	-0.011	0.31	NO
39	EDC4	EDC4	EDC4	10334	-0.014	0.3	NO
40	LSM3	LSM3	LSM3	10702	-0.02	0.29	NO
41	EXOSC8	EXOSC8	EXOSC8	11871	-0.038	0.25	NO
42	CNOT4	CNOT4	CNOT4	12596	-0.052	0.24	NO
43	DCP1A	DCP1A	DCP1A	12730	-0.055	0.26	NO
44	LSM5	LSM5	LSM5	13206	-0.065	0.27	NO

Fold change

For the top enriched genes, if you want to check whether they are

up-regulated, please check the list of up-regulated genes
down-regulated, please check the list of down-regulated genes

Expression level

For the top enriched genes, if you want to check whether they are

highly expressed genes, please check the list of high (top 30%) expressed genes
low expressed genes, please check the list of low (bottom 30%) expressed genes

An expression pattern of top(30%)/middle(30%)/low(30%) in this subtype against other subtypes is available in a heatmap

Significant gene list

For the top enriched genes, if you want to check whether they are

significantly differently expressed genes by eBayes lm fit, please check the list of significant genes

+ Methods & Data

Made with Nozzle

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	PDE3B	PDE3B	PDE3B	255	0.4	0.22	YES
2	STRADB	STRADB	STRADB	2645	0.13	0.16	YES
3	EIF4EBP1	EIF4EBP1	EIF4EBP1	2803	0.12	0.22	YES
4	PRKAG2	PRKAG2	PRKAG2	2980	0.12	0.28	YES
5	PRKAB2	PRKAB2	PRKAB2	3099	0.11	0.34	YES
6	EIF4E	EIF4E	EIF4E	3192	0.11	0.4	YES
7	EIF4B	EIF4B	EIF4B	4298	0.078	0.38	YES
8	PRKAA1	PRKAA1	PRKAA1	4626	0.071	0.4	YES
9	RHEB	RHEB	RHEB	5243	0.059	0.4	YES
10	PRKAG1	PRKAG1	PRKAG1	5377	0.056	0.43	YES
11	RPS6KB1	RPS6KB1	RPS6KB1	6231	0.043	0.4	YES
12	EEF2K	EEF2K	EEF2K	6280	0.042	0.43	YES
13	STK11	STK11	STK11	6820	0.034	0.42	YES
14	CAB39	CAB39	CAB39	6898	0.033	0.43	YES
15	RPS6	RPS6	RPS6	7040	0.031	0.44	YES
16	MLST8	MLST8	MLST8	7572	0.024	0.42	NO
17	CAB39L	CAB39L	CAB39L	8576	0.01	0.37	NO
18	TSC2	TSC2	TSC2	8982	0.0047	0.35	NO
19	RPTOR	RPTOR	RPTOR	9172	0.0022	0.34	NO
20	PPM1A	PPM1A	PPM1A	9256	0.00076	0.34	NO
21	AKT2	AKT2	AKT2	9303	0.00029	0.34	NO
22	EIF4G1	EIF4G1	EIF4G1	9447	-0.0018	0.33	NO
23	STRADA	STRADA	STRADA	10055	-0.01	0.3	NO
24	TSC1	TSC1	TSC1	10457	-0.016	0.29	NO
25	MTOR	MTOR	MTOR	12130	-0.043	0.22	NO
26	PRKAB1	PRKAB1	PRKAB1	13568	-0.073	0.18	NO
27	PRKAA2	PRKAA2	PRKAA2	14686	-0.11	0.18	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	LZTS1	LZTS1	LZTS1	1839	0.18	0.016	YES
2	SNAPC1	SNAPC1	SNAPC1	2338	0.15	0.085	YES
3	BRF2	BRF2	BRF2	2633	0.13	0.16	YES
4	POLR3D	POLR3D	POLR3D	2890	0.12	0.22	YES
5	POLR3C	POLR3C	POLR3C	3614	0.095	0.24	YES
6	POLR2K	POLR2K	POLR2K	3866	0.088	0.28	YES
7	POLR3A	POLR3A	POLR3A	4197	0.08	0.32	YES
8	SNAPC2	SNAPC2	SNAPC2	4372	0.076	0.36	YES
9	POLR3B	POLR3B	POLR3B	4460	0.075	0.4	YES
10	POLR3K	POLR3K	POLR3K	4773	0.068	0.43	YES
11	SNAPC3	SNAPC3	SNAPC3	4909	0.066	0.46	YES
12	SNAPC5	SNAPC5	SNAPC5	5695	0.051	0.46	NO
13	POLR1D	POLR1D	POLR1D	6492	0.039	0.44	NO
14	ZNF143	ZNF143	ZNF143	7302	0.027	0.41	NO
15	POLR3E	POLR3E	POLR3E	7657	0.022	0.4	NO
16	POLR1C	POLR1C	POLR1C	8235	0.015	0.38	NO
17	POLR2F	POLR2F	POLR2F	8742	0.0078	0.36	NO
18	POLR2E	POLR2E	POLR2E	9938	-0.0086	0.3	NO
19	TBP	TBP	TBP	10063	-0.01	0.3	NO
20	POLR3F	POLR3F	POLR3F	10390	-0.015	0.29	NO
21	POLR2L	POLR2L	POLR2L	10444	-0.016	0.3	NO
22	POLR3H	POLR3H	POLR3H	10569	-0.018	0.3	NO
23	POLR2H	POLR2H	POLR2H	10977	-0.024	0.29	NO
24	POLR3GL	POLR3GL	POLR3GL	11383	-0.03	0.29	NO
25	SNAPC4	SNAPC4	SNAPC4	12167	-0.044	0.28	NO
26	POU2F1	POU2F1	POU2F1	13516	-0.072	0.25	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	GPX2	GPX2	GPX2	210	0.41	0.068	YES
2	CCNB2	CCNB2	CCNB2	244	0.4	0.14	YES
3	TCF7L1	TCF7L1	TCF7L1	456	0.35	0.2	YES
4	HELLS	HELLS	HELLS	470	0.34	0.26	YES
5	TOP2A	TOP2A	TOP2A	532	0.33	0.32	YES
6	DLX6	DLX6	DLX6	749	0.3	0.37	YES
7	COL5A1	COL5A1	COL5A1	931	0.27	0.41	YES
8	BDKRB2	BDKRB2	BDKRB2	1024	0.26	0.46	YES
9	BRCA2	BRCA2	BRCA2	1371	0.22	0.48	YES
10	DLX5	DLX5	DLX5	1577	0.2	0.51	YES
11	RAB38	RAB38	RAB38	1763	0.19	0.54	YES
12	STXBP4	STXBP4	STXBP4	1782	0.19	0.57	YES
13	NRG1	NRG1	NRG1	2141	0.16	0.58	YES
14	TP63	TP63	TP63	2174	0.16	0.61	YES
15	ADA	ADA	ADA	2337	0.15	0.63	YES
16	FASN	FASN	FASN	2853	0.12	0.62	YES
17	IGFBP3	IGFBP3	IGFBP3	3052	0.11	0.64	YES
18	KRT14	KRT14	KRT14	3989	0.085	0.6	NO
19	WWP1	WWP1	WWP1	4969	0.064	0.56	NO
20	YAP1	YAP1	YAP1	5341	0.057	0.55	NO
21	GNB2L1	GNB2L1	GNB2L1	5614	0.052	0.54	NO
22	MRE11A	MRE11A	MRE11A	5890	0.048	0.54	NO
23	RUNX1	RUNX1	RUNX1	5939	0.048	0.54	NO
24	NOTCH1	NOTCH1	NOTCH1	6519	0.038	0.52	NO
25	PPP2R5A	PPP2R5A	PPP2R5A	7252	0.028	0.48	NO
26	ITCH	ITCH	ITCH	7392	0.026	0.48	NO
27	POU2F2	POU2F2	POU2F2	7769	0.021	0.46	NO
28	CDKN2A	CDKN2A	CDKN2A	8464	0.012	0.43	NO
29	MDM2	MDM2	MDM2	8632	0.0093	0.42	NO
30	ADRM1	ADRM1	ADRM1	8673	0.0087	0.42	NO
31	FOSL2	FOSL2	FOSL2	9060	0.0037	0.4	NO
32	KRT5	KRT5	KRT5	9076	0.0035	0.4	NO
33	IL1A	IL1A	IL1A	9381	-0.00085	0.38	NO
34	FBXW7	FBXW7	FBXW7	9489	-0.0024	0.38	NO
35	GSK3B	GSK3B	GSK3B	9550	-0.0031	0.37	NO
36	CEBPD	CEBPD	CEBPD	9950	-0.0088	0.35	NO
37	VDR	VDR	VDR	10388	-0.015	0.33	NO
38	ATM	ATM	ATM	10588	-0.018	0.32	NO
39	ITGA3	ITGA3	ITGA3	10606	-0.018	0.33	NO
40	SFN	SFN	SFN	10793	-0.021	0.32	NO
41	PERP	PERP	PERP	11151	-0.027	0.3	NO
42	HBP1	HBP1	HBP1	11698	-0.035	0.28	NO
43	SEC14L2	SEC14L2	SEC14L2	13478	-0.071	0.2	NO
44	AXL	AXL	AXL	13671	-0.076	0.2	NO
45	RRAD	RRAD	RRAD	14498	-0.1	0.17	NO
46	HES1	HES1	HES1	14674	-0.11	0.18	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	BUB1	BUB1	BUB1	31	0.57	0.042	YES
2	CCNE1	CCNE1	CCNE1	110	0.46	0.073	YES
3	ADCY1	ADCY1	ADCY1	138	0.45	0.1	YES
4	CDC25C	CDC25C	CDC25C	160	0.44	0.14	YES
5	CCNB2	CCNB2	CCNB2	244	0.4	0.16	YES
6	PTTG1	PTTG1	PTTG1	299	0.39	0.19	YES
7	MAD2L1	MAD2L1	MAD2L1	426	0.35	0.21	YES
8	CDK1	CDK1	CDK1	434	0.35	0.24	YES
9	CPEB1	CPEB1	CPEB1	513	0.34	0.26	YES
10	CCNB1	CCNB1	CCNB1	656	0.31	0.27	YES
11	PGR	PGR	PGR	701	0.3	0.29	YES
12	SGOL1	SGOL1	SGOL1	704	0.3	0.32	YES
13	CHP2	CHP2	CHP2	716	0.3	0.34	YES
14	ADCY3	ADCY3	ADCY3	762	0.3	0.36	YES
15	AURKA	AURKA	AURKA	809	0.29	0.38	YES
16	CCNE2	CCNE2	CCNE2	1061	0.26	0.38	YES
17	PLK1	PLK1	PLK1	1108	0.25	0.4	YES
18	CDC20	CDC20	CDC20	1177	0.24	0.42	YES
19	ESPL1	ESPL1	ESPL1	1285	0.23	0.43	YES
20	PKMYT1	PKMYT1	PKMYT1	1390	0.22	0.44	YES
21	ADCY4	ADCY4	ADCY4	1507	0.21	0.45	YES
22	SMC1B	SMC1B	SMC1B	1587	0.2	0.46	YES
23	CAMK2A	CAMK2A	CAMK2A	1594	0.2	0.47	YES
24	ITPR2	ITPR2	ITPR2	1721	0.19	0.48	YES
25	PTTG2	PTTG2	PTTG2	1810	0.18	0.49	YES
26	FBXO43	FBXO43	FBXO43	1932	0.17	0.5	YES
27	RPS6KA6	RPS6KA6	RPS6KA6	2065	0.16	0.5	YES
28	ITPR1	ITPR1	ITPR1	2364	0.15	0.5	YES
29	MAPK12	MAPK12	MAPK12	2439	0.14	0.5	YES
30	ANAPC1	ANAPC1	ANAPC1	2787	0.12	0.49	NO
31	FBXO5	FBXO5	FBXO5	2852	0.12	0.5	NO
32	FBXW11	FBXW11	FBXW11	3441	0.1	0.48	NO
33	SKP1	SKP1	SKP1	3971	0.086	0.45	NO
34	CDC27	CDC27	CDC27	4040	0.084	0.45	NO
35	ANAPC10	ANAPC10	ANAPC10	4181	0.081	0.45	NO
36	PPP2R5D	PPP2R5D	PPP2R5D	4225	0.08	0.46	NO
37	MAD2L2	MAD2L2	MAD2L2	4266	0.078	0.46	NO
38	SMC3	SMC3	SMC3	4287	0.078	0.46	NO
39	MAP2K1	MAP2K1	MAP2K1	4493	0.074	0.46	NO
40	ADCY7	ADCY7	ADCY7	4927	0.065	0.44	NO
41	ADCY8	ADCY8	ADCY8	4998	0.064	0.44	NO
42	PPP3R1	PPP3R1	PPP3R1	5180	0.06	0.44	NO
43	PPP2R5E	PPP2R5E	PPP2R5E	5452	0.055	0.42	NO
44	PPP1CC	PPP1CC	PPP1CC	5779	0.05	0.41	NO
45	PPP1CB	PPP1CB	PPP1CB	5803	0.05	0.41	NO
46	CDC23	CDC23	CDC23	5914	0.048	0.41	NO
47	SMC1A	SMC1A	SMC1A	5932	0.048	0.41	NO
48	YWHAB	YWHAB	YWHAB	6062	0.046	0.41	NO
49	PPP2CA	PPP2CA	PPP2CA	6245	0.043	0.4	NO
50	ADCY6	ADCY6	ADCY6	6303	0.042	0.4	NO
51	RPS6KA3	RPS6KA3	RPS6KA3	6336	0.041	0.4	NO
52	CALML6	CALML6	CALML6	6613	0.037	0.39	NO
53	SLK	SLK	SLK	6618	0.037	0.39	NO
54	PPP2R1B	PPP2R1B	PPP2R1B	6682	0.036	0.39	NO
55	YWHAQ	YWHAQ	YWHAQ	7126	0.029	0.37	NO
56	ANAPC5	ANAPC5	ANAPC5	7245	0.028	0.36	NO
57	PPP2R5A	PPP2R5A	PPP2R5A	7252	0.028	0.37	NO
58	PPP2R5C	PPP2R5C	PPP2R5C	7330	0.027	0.36	NO
59	PPP3CC	PPP3CC	PPP3CC	7529	0.024	0.36	NO
60	YWHAZ	YWHAZ	YWHAZ	7774	0.021	0.34	NO
61	PRKACA	PRKACA	PRKACA	7814	0.02	0.34	NO
62	CALM3	CALM3	CALM3	7912	0.019	0.34	NO
63	CHP	CHP	CHP	8052	0.017	0.33	NO
64	CDK2	CDK2	CDK2	8309	0.014	0.32	NO
65	PPP2CB	PPP2CB	PPP2CB	8377	0.013	0.32	NO
66	YWHAG	YWHAG	YWHAG	8480	0.012	0.31	NO
67	ANAPC11	ANAPC11	ANAPC11	8499	0.011	0.31	NO
68	CAMK2G	CAMK2G	CAMK2G	8655	0.009	0.3	NO
69	MAPK3	MAPK3	MAPK3	8769	0.0075	0.3	NO
70	PPP2R1A	PPP2R1A	PPP2R1A	8830	0.0068	0.3	NO
71	ANAPC7	ANAPC7	ANAPC7	8834	0.0067	0.3	NO
72	PPP3CA	PPP3CA	PPP3CA	8952	0.0051	0.29	NO
73	SPDYA	SPDYA	SPDYA	9079	0.0035	0.28	NO
74	CALM2	CALM2	CALM2	9101	0.0033	0.28	NO
75	CDC26	CDC26	CDC26	9112	0.0032	0.28	NO
76	CUL1	CUL1	CUL1	9458	-0.0019	0.26	NO
77	PPP1CA	PPP1CA	PPP1CA	10038	-0.01	0.23	NO
78	BTRC	BTRC	BTRC	10041	-0.01	0.23	NO
79	PPP3CB	PPP3CB	PPP3CB	10431	-0.016	0.21	NO
80	MAPK1	MAPK1	MAPK1	10625	-0.019	0.2	NO
81	CDC16	CDC16	CDC16	10841	-0.022	0.19	NO
82	ADCY5	ADCY5	ADCY5	11252	-0.028	0.17	NO
83	RBX1	RBX1	RBX1	11259	-0.029	0.17	NO
84	IGF1R	IGF1R	IGF1R	11365	-0.03	0.17	NO
85	ANAPC4	ANAPC4	ANAPC4	11896	-0.039	0.14	NO
86	CAMK2D	CAMK2D	CAMK2D	11930	-0.04	0.14	NO
87	YWHAE	YWHAE	YWHAE	11943	-0.04	0.14	NO
88	YWHAH	YWHAH	YWHAH	12310	-0.047	0.13	NO
89	PPP2R5B	PPP2R5B	PPP2R5B	13166	-0.064	0.085	NO
90	CALM1	CALM1	CALM1	13370	-0.069	0.079	NO
91	ITPR3	ITPR3	ITPR3	13543	-0.073	0.075	NO
92	ANAPC13	ANAPC13	ANAPC13	13631	-0.075	0.076	NO
93	ANAPC2	ANAPC2	ANAPC2	13759	-0.079	0.075	NO
94	PRKX	PRKX	PRKX	13770	-0.079	0.08	NO
95	IGF1	IGF1	IGF1	14477	-0.1	0.048	NO
96	PRKACB	PRKACB	PRKACB	14642	-0.11	0.047	NO
97	REC8	REC8	REC8	14702	-0.11	0.052	NO
98	RPS6KA1	RPS6KA1	RPS6KA1	14842	-0.11	0.053	NO
99	ADCY9	ADCY9	ADCY9	14844	-0.11	0.062	NO
100	CALML3	CALML3	CALML3	14954	-0.12	0.064	NO
101	RPS6KA2	RPS6KA2	RPS6KA2	15239	-0.13	0.058	NO
102	PLCZ1	PLCZ1	PLCZ1	15852	-0.16	0.036	NO
103	ADCY2	ADCY2	ADCY2	16006	-0.17	0.041	NO
104	STAG3	STAG3	STAG3	16419	-0.2	0.034	NO
105	AR	AR	AR	16907	-0.25	0.026	NO
106	CAMK2B	CAMK2B	CAMK2B	17775	-0.45	0.012	NO

Rank	GENE	SYMBOL	DESC	LIST.LOC	S2N	RES	CORE_ENRICHMENT
1	BUB1B	BUB1B	BUB1B	167	0.43	0.059	YES
2	PTTG1	PTTG1	PTTG1	299	0.39	0.11	YES
3	UBE2C	UBE2C	UBE2C	343	0.38	0.17	YES
4	MAD2L1	MAD2L1	MAD2L1	426	0.35	0.22	YES
5	CDK1	CDK1	CDK1	434	0.35	0.28	YES
6	CCNB1	CCNB1	CCNB1	656	0.31	0.32	YES
7	CCNA2	CCNA2	CCNA2	806	0.29	0.35	YES
8	AURKA	AURKA	AURKA	809	0.29	0.4	YES
9	AURKB	AURKB	AURKB	926	0.27	0.44	YES
10	PLK1	PLK1	PLK1	1108	0.25	0.46	YES
11	CDC20	CDC20	CDC20	1177	0.24	0.5	YES
12	SKP2	SKP2	SKP2	1778	0.19	0.5	YES
13	ANAPC1	ANAPC1	ANAPC1	2787	0.12	0.46	YES
14	FBXO5	FBXO5	FBXO5	2852	0.12	0.48	YES
15	UBE2D1	UBE2D1	UBE2D1	3349	0.1	0.46	YES
16	PSMD10	PSMD10	PSMD10	3520	0.098	0.47	YES
17	RPS27A	RPS27A	RPS27A	3903	0.087	0.46	YES
18	PSMD14	PSMD14	PSMD14	3937	0.087	0.47	YES
19	SKP1	SKP1	SKP1	3971	0.086	0.49	YES
20	CDC27	CDC27	CDC27	4040	0.084	0.5	YES
21	ANAPC10	ANAPC10	ANAPC10	4181	0.081	0.5	YES
22	PSMD8	PSMD8	PSMD8	4360	0.077	0.5	YES
23	CCNA1	CCNA1	CCNA1	4478	0.074	0.51	YES
24	PSME4	PSME4	PSME4	4827	0.067	0.5	YES
25	PSMD11	PSMD11	PSMD11	4836	0.067	0.51	YES
26	PSMD1	PSMD1	PSMD1	4992	0.064	0.51	YES
27	PSMA1	PSMA1	PSMA1	5743	0.051	0.48	NO
28	UBA52	UBA52	UBA52	5820	0.05	0.48	NO
29	PSMD12	PSMD12	PSMD12	5893	0.048	0.48	NO
30	CDC23	CDC23	CDC23	5914	0.048	0.49	NO
31	PSMD4	PSMD4	PSMD4	5983	0.047	0.49	NO
32	PSMB4	PSMB4	PSMB4	6199	0.044	0.49	NO
33	PSMD3	PSMD3	PSMD3	6342	0.041	0.49	NO
34	PSMA6	PSMA6	PSMA6	6464	0.039	0.49	NO
35	PSMA7	PSMA7	PSMA7	6517	0.038	0.49	NO
36	BUB3	BUB3	BUB3	6549	0.038	0.5	NO
37	PSMA4	PSMA4	PSMA4	6701	0.036	0.49	NO
38	ANAPC5	ANAPC5	ANAPC5	7245	0.028	0.47	NO
39	UBE2E1	UBE2E1	UBE2E1	7448	0.025	0.46	NO
40	PSMA3	PSMA3	PSMA3	7546	0.024	0.46	NO
41	PSMD2	PSMD2	PSMD2	7549	0.024	0.46	NO
42	PSMC4	PSMC4	PSMC4	7669	0.022	0.46	NO
43	PSMF1	PSMF1	PSMF1	7742	0.021	0.46	NO
44	PSMC6	PSMC6	PSMC6	8041	0.018	0.44	NO
45	PSMB5	PSMB5	PSMB5	8161	0.016	0.44	NO
46	PSMB2	PSMB2	PSMB2	8282	0.014	0.43	NO
47	CDK2	CDK2	CDK2	8309	0.014	0.44	NO
48	ANAPC11	ANAPC11	ANAPC11	8499	0.011	0.43	NO
49	PSMD13	PSMD13	PSMD13	8787	0.0072	0.41	NO
50	ANAPC7	ANAPC7	ANAPC7	8834	0.0067	0.41	NO
51	CDC26	CDC26	CDC26	9112	0.0032	0.4	NO
52	PSMD7	PSMD7	PSMD7	9118	0.0031	0.4	NO
53	PSMA5	PSMA5	PSMA5	9415	-0.0014	0.38	NO
54	CUL1	CUL1	CUL1	9458	-0.0019	0.38	NO
55	PSMD9	PSMD9	PSMD9	9517	-0.0027	0.37	NO
56	PSMB3	PSMB3	PSMB3	9689	-0.0049	0.36	NO
57	PSMC3	PSMC3	PSMC3	9730	-0.0056	0.36	NO
58	PSMB7	PSMB7	PSMB7	9891	-0.0077	0.36	NO
59	BTRC	BTRC	BTRC	10041	-0.01	0.35	NO
60	PSMB1	PSMB1	PSMB1	10138	-0.012	0.35	NO
61	PSMD6	PSMD6	PSMD6	10197	-0.013	0.34	NO
62	PSMC5	PSMC5	PSMC5	10396	-0.015	0.34	NO
63	PSME2	PSME2	PSME2	10552	-0.018	0.33	NO
64	PSMC2	PSMC2	PSMC2	10711	-0.02	0.32	NO
65	CDC16	CDC16	CDC16	10841	-0.022	0.32	NO
66	PSMA2	PSMA2	PSMA2	10948	-0.024	0.32	NO
67	PSMC1	PSMC1	PSMC1	11020	-0.025	0.32	NO
68	PSME1	PSME1	PSME1	11351	-0.03	0.3	NO
69	CDC14A	CDC14A	CDC14A	11721	-0.036	0.29	NO
70	ANAPC4	ANAPC4	ANAPC4	11896	-0.039	0.29	NO
71	PSMB8	PSMB8	PSMB8	12008	-0.041	0.29	NO
72	PSMB10	PSMB10	PSMB10	12056	-0.042	0.29	NO
73	PSMD5	PSMD5	PSMD5	12195	-0.044	0.29	NO
74	PSMB6	PSMB6	PSMB6	12557	-0.052	0.28	NO
75	PSMB9	PSMB9	PSMB9	13666	-0.076	0.23	NO
76	ANAPC2	ANAPC2	ANAPC2	13759	-0.079	0.24	NO