Clustering of miRseq precursor expression: consensus NMF
Brain Lower Grade Glioma (Primary solid tumor)
28 January 2016
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analyses__2016_01_28
Maintainer Information
Citation Information
Maintained by Hailei Zhang
(Broad Institute)
Cite as
Broad Institute TCGA Genome Data Analysis Center
(2016):
Clustering of miRseq precursor expression: consensus NMF.
Broad Institute of MIT and Harvard.
doi:10.7908/C190236J
Overview
Introduction
Summary
The most robust consensus NMF clustering of 512 samples using the 150 most variable miRs was identified for k = 4 clusters. We computed the clustering for k = 2 to k = 10 and uused the cophenetic correlation coefficient and the average silhouette width calculation to determine the robust clusters.
Results
miR expression patterns of molecular subtypes
Silhouette widths, Cophenetic Correlation Coefficients and Consensus matrix
Samples assignment with silhouette width
Marker miRs of each subtype
Methods & Data
Copyright © 2016
Broad Institute TCGA GDAC as part of the TCGA Research Network.
All rights reserved.