PARADIGM pathway analysis of mRNA expression data
Ovarian Serous Cystadenocarcinoma (Primary solid tumor)
28 January 2016  |  analyses__2016_01_28
Maintainer Information
Citation Information
doi:10.7908/C1XK8F0Q
Maintained by TCGA GDAC Team (Broad Institute/MD Anderson Cancer Center/Harvard Medical School)
Cite as Broad Institute TCGA Genome Data Analysis Center (2016): PARADIGM pathway analysis of mRNA expression data. Broad Institute of MIT and Harvard. doi:10.7908/C1XK8F0Q
Overview
Introduction

PAthway Representation and Analysis by Direct Inference on Graphical Models (PARADIGM) predicts the activity of a diverse set of molecular concepts such as genes, complexes, and processes. The predicted activities are called Inferred Pathway Levels (IPLs) and are derived from a probabilistic belief propagation strategy that incorporates multimodal data such as copy number and gene expression estimates with a concept's pathway context.

Summary

There were 64 significant pathways identified in this analysis.

Table 1.  Get Full Table Top 10 out of 131 pathways in order of significance.

Pathway.Name Avg.Num.Perturbations
FOXM1 transcription factor network 418
PLK1 signaling events 234
TCGA08_retinoblastoma 228
PLK2 and PLK4 events 215
Aurora B signaling 186
Circadian rhythm pathway 156
TCGA08_p53 123
Signaling events regulated by Ret tyrosine kinase 120
Osteopontin-mediated events 118
Nongenotropic Androgen signaling 110
Results
Summary Table

The following list describes the columns found in Table 2.

  • Pathway.Name = Full pathway name of curated PARADIGM pathway

  • Significance.Ratio = (Ave.Num.Perturbations)/ (Cohort Size) where Cohort Size is 569 . Pathway is significant if Significance.Ratio > 0.05 .

  • Avg.Num.Perturbations = Average number of samples with perturbations across the pathway concepts determined by a background permutation model (>2 standard deviations away from the permuted distribution)

  • Total.Perturbations = Total number of perturbed concepts across all samples (>2 standard deviations away from the permuted distribution)

  • Num.Entities = Number of concepts that belong to the pathway

  • Min.Mean.Truth = Minimum IPL for concepts in the pathway among real samples

  • Max.Mean.Truth = Maximum IPL for concepts in the pathway among real samples

  • Min.Mean.Within = Minimum IPL for concepts in the pathway among null samples using "within permutation" (values are permuted across genes)

  • Max.Mean.Within = Maximum IPL for concepts in the pathway among null samples using "within permutation" (values are permuted across genes)

  • Min.Mean.Any = Minimum IPL for concepts in the pathway among null samples using "any permutation" (values are permuted across samples and genes)

  • Max.Mean.Any = Maximum IPL for concepts in the pathway among null samples using "any permutation" (values are permuted across samples and genes).

Table 2.  Get Full Table This summary table provides a report of cancer type specific pathway perturbations. Click on the links in the first column to display more detailed results for each pathway. A pathway is defined as significant (red number in Significance.Ratio column) if the Ave.Num.Perturbationsis > 5% of the cohort size ( 569 ).

Pathway.Name Significance.Ratio Avg.Num.Perturbations Total.Perturbations Num.Entities Min.Mean.Truth Max.Mean.Truth Min.Mean.Within Max.Mean.Within Min.Mean.Any Max.Mean.Within.1
FOXM1 transcription factor network 0.7346 418 21358 51 -0.035 2.3 1000 -1000 -0.16 -1000
PLK1 signaling events 0.4112 234 19932 85 -0.13 0.32 1000 -1000 -0.027 -1000
TCGA08_retinoblastoma 0.4007 228 1827 8 -0.11 0.14 1000 -1000 -0.009 -1000
PLK2 and PLK4 events 0.3779 215 646 3 0.029 0.12 1000 -1000 -0.008 -1000
Aurora B signaling 0.3269 186 12489 67 -0.25 0.42 1000 -1000 -0.022 -1000
Circadian rhythm pathway 0.2742 156 3436 22 -0.079 0.32 1000 -1000 -0.035 -1000
TCGA08_p53 0.2162 123 866 7 -0.075 0.003 1000 -1000 -0.004 -1000
Signaling events regulated by Ret tyrosine kinase 0.2109 120 9854 82 -0.24 0.066 1000 -1000 -0.042 -1000
Osteopontin-mediated events 0.2074 118 4515 38 -0.13 0.17 1000 -1000 -0.021 -1000
Nongenotropic Androgen signaling 0.1933 110 5747 52 -0.2 0.094 1000 -1000 -0.021 -1000
BARD1 signaling events 0.1916 109 6237 57 -0.051 0.22 1000 -1000 -0.027 -1000
Aurora A signaling 0.1898 108 6485 60 -0.25 0.29 1000 -1000 -0.016 -1000
HIF-1-alpha transcription factor network 0.1757 100 7632 76 -0.027 0.32 1000 -1000 -0.051 -1000
IL2 signaling events mediated by STAT5 0.1757 100 2220 22 -0.42 0.21 1000 -1000 -0.029 -1000
mTOR signaling pathway 0.1634 93 4957 53 -0.18 0.047 1000 -1000 -0.034 -1000
Insulin Pathway 0.1599 91 6791 74 -0.2 0.047 1000 -1000 -0.038 -1000
S1P3 pathway 0.1599 91 3833 42 -0.56 0.02 1000 -1000 -0.026 -1000
IGF1 pathway 0.1564 89 5096 57 -0.1 0.085 1000 -1000 -0.038 -1000
TCGA08_rtk_signaling 0.1353 77 2020 26 -0.18 0.12 1000 -1000 -0.011 -1000
Endothelins 0.1336 76 7332 96 -0.11 0.15 1000 -1000 -0.036 -1000
Coregulation of Androgen receptor activity 0.1248 71 5446 76 -0.34 0.13 1000 -1000 -0.027 -1000
Signaling events mediated by PRL 0.1248 71 2441 34 -0.083 0.16 1000 -1000 -0.014 -1000
PDGFR-alpha signaling pathway 0.1213 69 3061 44 -0.084 0.047 1000 -1000 -0.016 -1000
Syndecan-1-mediated signaling events 0.1195 68 2329 34 -0.1 0.047 1000 -1000 -0.02 -1000
Reelin signaling pathway 0.1178 67 3799 56 -0.075 0.047 1000 -1000 -0.034 -1000
Integrins in angiogenesis 0.1178 67 5651 84 -0.2 0.079 1000 -1000 -0.039 -1000
IL1-mediated signaling events 0.1142 65 4090 62 -0.12 0.1 1000 -1000 -0.036 -1000
Ephrin B reverse signaling 0.1125 64 3104 48 -0.16 0.047 1000 -1000 -0.027 -1000
LPA receptor mediated events 0.1107 63 6510 102 -0.075 0.035 1000 -1000 -0.041 -1000
Ras signaling in the CD4+ TCR pathway 0.1054 60 1028 17 -0.007 0.12 1000 -1000 -0.013 -1000
Thromboxane A2 receptor signaling 0.1002 57 6080 105 -0.2 0.064 1000 -1000 -0.046 -1000
IL4-mediated signaling events 0.0984 56 5168 91 -0.65 0.22 1000 -1000 -0.16 -1000
Nectin adhesion pathway 0.0967 55 3521 63 -0.12 0.047 1000 -1000 -0.04 -1000
FAS signaling pathway (CD95) 0.0896 51 2436 47 -0.057 0.065 1000 -1000 -0.024 -1000
TRAIL signaling pathway 0.0879 50 2447 48 -0.12 0.015 1000 -1000 -0.02 -1000
Plasma membrane estrogen receptor signaling 0.0879 50 4355 86 -0.096 0.12 1000 -1000 -0.04 -1000
amb2 Integrin signaling 0.0861 49 4020 82 -0.14 0.075 1000 -1000 -0.031 -1000
IL23-mediated signaling events 0.0861 49 2981 60 -0.076 0.2 1000 -1000 -0.13 -1000
Signaling events mediated by the Hedgehog family 0.0844 48 2506 52 -0.075 0.12 1000 -1000 -0.024 -1000
Effects of Botulinum toxin 0.0808 46 1216 26 -0.15 0.011 1000 -1000 -0.019 -1000
p75(NTR)-mediated signaling 0.0791 45 5749 125 -0.18 0.1 1000 -1000 -0.036 -1000
FoxO family signaling 0.0773 44 2870 64 -0.072 0.3 1000 -1000 -0.033 -1000
Signaling mediated by p38-gamma and p38-delta 0.0773 44 668 15 -0.092 0.04 1000 -1000 -0.017 -1000
Retinoic acid receptors-mediated signaling 0.0756 43 2520 58 -0.38 0.23 1000 -1000 -0.038 -1000
Syndecan-4-mediated signaling events 0.0721 41 2776 67 -0.045 0.089 1000 -1000 -0.033 -1000
Syndecan-2-mediated signaling events 0.0703 40 2760 69 -0.054 0.075 1000 -1000 -0.014 -1000
Cellular roles of Anthrax toxin 0.0685 39 1551 39 -0.14 0.014 1000 -1000 -0.013 -1000
HIF-2-alpha transcription factor network 0.0685 39 1711 43 -0.14 0.18 1000 -1000 -0.045 -1000
IL2 signaling events mediated by PI3K 0.0685 39 2277 58 -0.17 0.045 1000 -1000 -0.05 -1000
Paxillin-dependent events mediated by a4b1 0.0668 38 1390 36 -0.075 0.047 1000 -1000 -0.023 -1000
Insulin-mediated glucose transport 0.0650 37 1207 32 -0.23 0.1 1000 -1000 -0.031 -1000
Aurora C signaling 0.0615 35 248 7 -0.006 0.046 1000 -1000 -0.012 -1000
Paxillin-independent events mediated by a4b1 and a4b7 0.0615 35 1331 37 -0.075 0.047 1000 -1000 -0.015 -1000
Regulation of Telomerase 0.0615 35 3601 102 -0.27 0.084 1000 -1000 -0.062 -1000
Signaling events mediated by PTP1B 0.0598 34 2647 76 -0.2 0.082 1000 -1000 -0.037 -1000
RXR and RAR heterodimerization with other nuclear receptor 0.0598 34 1790 52 -0.16 0.044 1000 -1000 -0.02 -1000
Fc-epsilon receptor I signaling in mast cells 0.0580 33 3251 97 -0.074 0.047 1000 -1000 -0.042 -1000
Canonical NF-kappaB pathway 0.0562 32 1286 39 -0.022 0.073 1000 -1000 -0.033 -1000
ceramide signaling pathway 0.0562 32 1594 49 -0.055 0.001 1000 -1000 -0.024 -1000
Regulation of Androgen receptor activity 0.0562 32 2303 70 -0.42 0.021 1000 -1000 -0.035 -1000
IL6-mediated signaling events 0.0545 31 2340 75 -0.28 0.11 1000 -1000 -0.039 -1000
E-cadherin signaling in keratinocytes 0.0527 30 1329 43 -0.073 0.044 1000 -1000 -0.02 -1000
Class I PI3K signaling events 0.0510 29 2135 73 -0.047 0.12 1000 -1000 -0.03 -1000
Neurotrophic factor-mediated Trk receptor signaling 0.0510 29 3575 120 -0.16 0.12 1000 -1000 -0.036 -1000
LPA4-mediated signaling events 0.0492 28 346 12 -0.085 0 1000 -1000 -0.012 -1000
Caspase cascade in apoptosis 0.0492 28 2077 74 -0.047 0.077 1000 -1000 -0.02 -1000
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met) 0.0492 28 2438 85 -0.075 0.047 1000 -1000 -0.031 -1000
EPHB forward signaling 0.0492 28 2405 85 -0.075 0.12 1000 -1000 -0.04 -1000
BMP receptor signaling 0.0475 27 2247 81 -0.14 0.041 1000 -1000 -0.047 -1000
Regulation of cytoplasmic and nuclear SMAD2/3 signaling 0.0457 26 610 23 -0.013 0.21 1000 -1000 -0.022 -1000
IL12-mediated signaling events 0.0457 26 2311 87 -0.39 0.13 1000 -1000 -0.11 -1000
ErbB4 signaling events 0.0457 26 1796 69 -0.23 0.21 1000 -1000 -0.051 -1000
Lissencephaly gene (LIS1) in neuronal migration and development 0.0457 26 1444 54 -0.048 0.021 1000 -1000 -0.042 -1000
Glypican 1 network 0.0457 26 1277 48 -0.13 0.036 1000 -1000 -0.016 -1000
Glucocorticoid receptor regulatory network 0.0457 26 2968 114 -0.29 0.14 1000 -1000 -0.043 -1000
ErbB2/ErbB3 signaling events 0.0439 25 1638 65 -0.019 0.13 1000 -1000 -0.03 -1000
Role of Calcineurin-dependent NFAT signaling in lymphocytes 0.0439 25 2115 83 -0.15 0.21 1000 -1000 -0.03 -1000
Stabilization and expansion of the E-cadherin adherens junction 0.0422 24 1833 74 -0.12 0.029 1000 -1000 -0.037 -1000
PDGFR-beta signaling pathway 0.0422 24 2339 97 -0.088 0.13 1000 -1000 -0.034 -1000
Canonical Wnt signaling pathway 0.0404 23 1182 51 -0.34 0.13 1000 -1000 -0.044 -1000
EGFR-dependent Endothelin signaling events 0.0404 23 486 21 -0.03 0.007 1000 -1000 -0.027 -1000
Regulation of nuclear SMAD2/3 signaling 0.0387 22 3076 136 -0.18 0.14 1000 -1000 -0.031 -1000
Wnt signaling 0.0387 22 157 7 -0.006 0.021 1000 -1000 -0.013 -1000
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha 0.0387 22 746 33 -0.051 0.13 1000 -1000 -0.026 -1000
Arf6 signaling events 0.0369 21 1322 62 -0.046 0.029 1000 -1000 -0.018 -1000
IFN-gamma pathway 0.0369 21 1461 68 -0.075 0.077 1000 -1000 -0.052 -1000
a4b1 and a4b7 Integrin signaling 0.0351 20 103 5 -0.006 0.007 1000 -1000 -0.009 -1000
Signaling mediated by p38-alpha and p38-beta 0.0351 20 898 44 -0.088 0.02 1000 -1000 -0.019 -1000
TCR signaling in naïve CD8+ T cells 0.0351 20 1930 93 -0.049 0.12 1000 -1000 -0.042 -1000
Presenilin action in Notch and Wnt signaling 0.0334 19 1184 61 -0.32 0.025 1000 -1000 -0.033 -1000
Atypical NF-kappaB pathway 0.0334 19 601 31 -0.075 0.047 1000 -1000 -0.015 -1000
HIV-1 Nef: Negative effector of Fas and TNF-alpha 0.0334 19 857 45 -0.07 0.024 1000 -1000 -0.044 -1000
Signaling events mediated by Stem cell factor receptor (c-Kit) 0.0334 19 1538 78 -0.16 0.047 1000 -1000 -0.063 -1000
FOXA2 and FOXA3 transcription factor networks 0.0316 18 839 46 -0.019 0.21 1000 -1000 -0.082 -1000
Ceramide signaling pathway 0.0316 18 1414 76 -0.055 0.048 1000 -1000 -0.024 -1000
Syndecan-3-mediated signaling events 0.0316 18 641 35 -0.047 0.019 1000 -1000 -0.022 -1000
E-cadherin signaling in the nascent adherens junction 0.0316 18 1425 76 -0.075 0.047 1000 -1000 -0.037 -1000
Signaling events mediated by VEGFR1 and VEGFR2 0.0299 17 2222 125 -0.08 0.047 1000 -1000 -0.048 -1000
IL27-mediated signaling events 0.0299 17 913 51 -0.054 0.13 1000 -1000 -0.034 -1000
Ephrin A reverse signaling 0.0281 16 112 7 -0.028 0.006 1000 -1000 -0.009 -1000
Regulation of p38-alpha and p38-beta 0.0281 16 892 54 -0.094 0.03 1000 -1000 -0.035 -1000
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 0.0281 16 1144 68 -0.12 0.008 1000 -1000 -0.065 -1000
Arf6 downstream pathway 0.0264 15 663 43 -0.021 0.019 1000 -1000 -0.021 -1000
BCR signaling pathway 0.0264 15 1485 99 -0.075 0.047 1000 -1000 -0.042 -1000
Calcium signaling in the CD4+ TCR pathway 0.0246 14 452 31 -0.077 0 1000 -1000 -0.031 -1000
Noncanonical Wnt signaling pathway 0.0228 13 346 26 -0.018 0.024 1000 -1000 -0.031 -1000
S1P1 pathway 0.0228 13 480 36 -0.009 0.037 1000 -1000 -0.033 -1000
E-cadherin signaling events 0.0228 13 69 5 -0.013 0.001 1000 -1000 -0.008 -1000
Arf1 pathway 0.0228 13 713 54 -0.024 0.005 1000 -1000 -0.015 -1000
EPO signaling pathway 0.0211 12 661 55 -0.085 0.029 1000 -1000 -0.036 -1000
Signaling events mediated by HDAC Class I 0.0193 11 1213 104 -0.021 0.026 1000 -1000 -0.027 -1000
Nephrin/Neph1 signaling in the kidney podocyte 0.0176 10 354 34 -0.017 0.021 1000 -1000 -0.015 -1000
Signaling events mediated by HDAC Class III 0.0176 10 403 40 -0.047 0.01 1000 -1000 -0.015 -1000
VEGFR1 specific signals 0.0176 10 609 56 -0.075 0.047 1000 -1000 -0.026 -1000
Sphingosine 1-phosphate (S1P) pathway 0.0141 8 243 28 -0.034 0.036 1000 -1000 -0.014 -1000
Hedgehog signaling events mediated by Gli proteins 0.0141 8 521 65 -0.056 0.035 1000 -1000 -0.036 -1000
S1P5 pathway 0.0141 8 140 17 -0.009 0.036 1000 -1000 -0.012 -1000
Angiopoietin receptor Tie2-mediated signaling 0.0141 8 786 88 -0.075 0.075 1000 -1000 -0.075 -1000
Signaling events mediated by HDAC Class II 0.0123 7 563 75 -0.046 0.014 1000 -1000 -0.019 -1000
Class I PI3K signaling events mediated by Akt 0.0123 7 537 68 -0.14 0.036 1000 -1000 -0.027 -1000
p38 MAPK signaling pathway 0.0123 7 320 44 -0.012 0.02 1000 -1000 -0.038 -1000
Arf6 trafficking events 0.0105 6 455 71 -0.008 0.009 1000 -1000 -0.024 -1000
Class IB PI3K non-lipid kinase events 0.0105 6 18 3 -0.003 -1000 1000 -1000 -0.009 -1000
Sumoylation by RanBP2 regulates transcriptional repression 0.0088 5 135 27 -0.008 0.014 1000 -1000 -0.024 -1000
S1P4 pathway 0.0088 5 147 25 -0.008 0.036 1000 -1000 -0.014 -1000
JNK signaling in the CD4+ TCR pathway 0.0070 4 72 17 -0.015 0.008 1000 -1000 -0.021 -1000
Alternative NF-kappaB pathway 0.0070 4 60 13 -0.01 0.016 1000 -1000 -0.009 -1000
Visual signal transduction: Rods 0.0053 3 160 52 -0.017 0.012 1000 -1000 -0.031 -1000
Visual signal transduction: Cones 0.0000 0 30 38 -0.011 0.011 1000 -1000 -0.011 -1000
Glypican 2 network 0.0000 0 3 4 -0.007 -1000 1000 -1000 -0.007 -1000
Rapid glucocorticoid signaling 0.0000 0 17 20 -0.006 0.006 1000 -1000 -0.008 -1000
Total NA 5960 323013 7203 -15 -2000 131000 -131000 -4.2 -131000
FOXM1 transcription factor network

Figure S1.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S1.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
NFATC3 1.3 0.29 1.3 520 -10000 0 520
PLK1 0.47 0.28 0.65 316 -10000 0 316
BIRC5 0.49 0.3 0.7 308 -10000 0 308
HSPA1B 1.3 0.29 1.3 525 -10000 0 525
MAP2K1 0.45 0.13 0.47 542 -10000 0 542
BRCA2 1.4 0.41 1.5 526 -10000 0 526
FOXM1 2.3 0.81 2.4 526 -10000 0 526
XRCC1 1.3 0.29 1.3 520 -10000 0 520
FOXM1B/p19 0.73 0.59 1.2 328 -10000 0 328
Cyclin D1/CDK4 0.71 0.48 1 372 -10000 0 372
CDC2 1.9 0.52 2 537 -10000 0 537
TGFA 0.76 0.5 1.1 372 -10000 0 372
SKP2 1.4 0.4 1.5 521 -10000 0 521
CCNE1 0.27 0.068 0.3 515 -10000 0 515
CKS1B 1.5 0.44 1.6 521 -10000 0 521
RB1 0 0.03 0.62 1 -10000 0 1
FOXM1C/SP1 0.93 0.39 1.1 457 -10000 0 457
AURKB 0.5 0.31 0.7 314 -10000 0 314
CENPF 1.7 0.41 1.8 533 -10000 0 533
CDK4 0.11 0.066 0.16 344 -10000 0 344
MYC 0.92 0.38 1.1 462 -10000 0 462
CHEK2 0.51 0.16 0.53 543 -10000 0 543
ONECUT1 0.8 0.53 1.2 373 -10000 0 373
CDKN2A 0.049 0.16 0.24 183 -0.29 61 244
LAMA4 1.2 0.48 1.4 480 -0.97 2 482
FOXM1B/HNF6 0.81 0.54 1.2 372 -10000 0 372
FOS 1.1 0.51 1.4 463 -10000 0 463
SP1 -0.035 0.082 -10000 0 -0.28 58 58
CDC25B 1.3 0.29 1.4 520 -10000 0 520
response to radiation 0.23 0.059 0.24 537 -10000 0 537
CENPB 1.3 0.29 1.3 518 -10000 0 518
CENPA 1.3 0.3 1.4 524 -10000 0 524
NEK2 1.6 0.44 1.7 523 -10000 0 523
HIST1H2BA 1.3 0.29 1.3 520 -10000 0 520
CCNA2 0.27 0.082 0.3 496 -10000 0 496
EP300 -0.007 0.018 -10000 0 -0.31 2 2
CCNB1/CDK1 1.8 0.47 1.9 523 -10000 0 523
CCNB2 1.7 0.4 1.8 537 -10000 0 537
CCNB1 1.9 0.54 2 525 -10000 0 525
ETV5 1.3 0.34 1.4 526 -10000 0 526
ESR1 1.1 0.52 1.3 452 -1 2 454
CCND1 0.8 0.53 1.2 373 -10000 0 373
GSK3A 0.24 0.061 0.25 513 -10000 0 513
Cyclin A-E1/CDK1-2 0.51 0.13 0.52 551 -10000 0 551
CDK2 0.18 0.1 0.28 265 -10000 0 265
G2/M transition of mitotic cell cycle 0.44 0.13 0.46 543 -10000 0 543
FOXM1B/Cbp/p300 -0.003 0.036 -10000 0 -10000 0 0
GAS1 1.1 0.53 1.3 450 -0.98 1 451
MMP2 1.1 0.54 1.4 465 -0.97 4 469
RB1/FOXM1C 0.78 0.52 1.1 382 -10000 0 382
CREBBP -0.012 0.042 -10000 0 -0.31 11 11
PLK1 signaling events

Figure S2.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S2.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
regulation of centriole-centriole cohesion -0.13 0.048 -10000 0 -0.15 494 494
BUB1B 0.22 0.068 0.24 514 -10000 0 514
PLK1 0.1 0.037 0.11 518 -10000 0 518
PLK1S1 0.051 0.021 0.058 456 -10000 0 456
KIF2A 0.088 0.032 0.099 447 -0.12 1 448
regulation of mitotic centrosome separation 0.1 0.036 0.11 518 -10000 0 518
GOLGA2 -0.006 0 -10000 0 -10000 0 0
Hec1/SPC24 0.25 0.1 0.28 508 -10000 0 508
WEE1 0.15 0.042 0.17 435 -10000 0 435
cytokinesis 0.25 0.089 0.28 499 -10000 0 499
PP2A-alpha B56 0.027 0.058 -10000 0 -10000 0 0
AURKA 0.14 0.036 0.14 538 -10000 0 538
PICH/PLK1 0.27 0.091 0.28 543 -10000 0 543
CENPE 0.1 0.056 0.11 447 -10000 0 447
RhoA/GTP -0.004 0.012 -10000 0 -0.21 2 2
positive regulation of microtubule depolymerization 0.087 0.032 0.099 447 -0.12 1 448
PPP2CA -0.006 0.013 -10000 0 -0.31 1 1
FZR1 -0.006 0 -10000 0 -10000 0 0
TPX2 0.16 0.03 0.16 556 -10000 0 556
PAK1 0.012 0.041 0.24 18 -10000 0 18
SPC24 0.063 0.11 0.24 157 -10000 0 157
FBXW11 -0.006 0 -10000 0 -10000 0 0
CLSPN 0.07 0.041 0.15 81 -10000 0 81
GORASP1 -0.006 0 -10000 0 -10000 0 0
metaphase 0.001 0.002 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
NLP 0.051 0.021 0.058 456 -10000 0 456
G2 phase of mitotic cell cycle 0.007 0.002 0.009 121 -10000 0 121
STAG2 0.001 0.043 0.24 16 -0.31 1 17
GRASP65/GM130/RAB1/GTP 0 0.001 -10000 0 -10000 0 0
spindle elongation 0.1 0.036 0.11 518 -10000 0 518
ODF2 0.011 0.003 -10000 0 -10000 0 0
BUB1 0.029 0.07 0.39 2 -10000 0 2
TPT1 0.051 0.023 0.094 42 -0.18 1 43
CDC25C 0.12 0.075 0.2 251 -10000 0 251
CDC25B 0.028 0.028 0.26 8 -10000 0 8
SGOL1 0.13 0.048 0.15 494 -10000 0 494
RHOA -0.007 0.018 -10000 0 -0.31 2 2
CCNB1/CDK1 0.27 0.083 0.28 531 -10000 0 531
CDC14B 0.004 0.002 -10000 0 -10000 0 0
CDC20 0.18 0.1 0.24 438 -10000 0 438
PLK1/PBIP1 0.01 0.043 0.21 24 -10000 0 24
mitosis 0 0.001 -10000 0 -10000 0 0
FBXO5 0.17 0.075 0.2 479 -10000 0 479
CDC2 0.24 0.045 0.24 549 -10000 0 549
NDC80 0.21 0.078 0.24 505 -10000 0 505
metaphase plate congression 0.065 0.023 0.11 41 -0.15 1 42
ERCC6L 0.27 0.089 0.28 520 -10000 0 520
NLP/gamma Tubulin 0.052 0.023 0.077 212 -10000 0 212
microtubule cytoskeleton organization 0.051 0.023 0.094 42 -0.17 1 43
G2/M transition DNA damage checkpoint 0.001 0.001 -10000 0 -10000 0 0
PPP1R12A 0.006 0.003 -10000 0 -10000 0 0
interphase 0.001 0.001 -10000 0 -10000 0 0
PLK1/PRC1-2 0.32 0.12 0.35 509 -10000 0 509
GRASP65/GM130/RAB1/GTP/PLK1 0.039 0.031 0.2 1 -10000 0 1
RAB1A -0.005 0.01 0.24 1 -10000 0 1
prophase 0 0 -10000 0 -10000 0 0
Aurora A/BORA 0.12 0.068 0.13 516 -10000 0 516
mitotic prometaphase 0.003 0.002 0.033 1 -10000 0 1
proteasomal ubiquitin-dependent protein catabolic process 0.099 0.042 0.15 39 -10000 0 39
microtubule-based process 0.22 0.077 0.25 484 -10000 0 484
Golgi organization 0.1 0.036 0.11 518 -10000 0 518
Cohesin/SA2 0.054 0.046 0.13 68 -10000 0 68
PPP1CB/MYPT1 0.012 0.01 -10000 0 -0.22 1 1
KIF20A 0.2 0.091 0.24 477 -10000 0 477
APC/C/CDC20 0.21 0.086 0.25 447 -10000 0 447
PPP2R1A -0.006 0 -10000 0 -10000 0 0
chromosome segregation 0.01 0.042 0.21 24 -10000 0 24
PRC1 0.18 0.11 0.24 429 -10000 0 429
ECT2 0.22 0.06 0.24 532 -10000 0 532
C13orf34 0.11 0.068 0.13 447 -10000 0 447
NUDC 0.065 0.023 0.11 41 -0.15 1 42
regulation of attachment of spindle microtubules to kinetochore 0.22 0.068 0.24 514 -10000 0 514
spindle assembly 0.076 0.03 0.087 448 -10000 0 448
spindle stabilization 0.051 0.021 0.058 456 -10000 0 456
APC/C/HCDH1 0.006 0.003 -10000 0 -10000 0 0
MKLP2/PLK1 0.22 0.078 0.25 484 -10000 0 484
CCNB1 0.2 0.095 0.25 448 -10000 0 448
PPP1CB 0.006 0.014 -10000 0 -0.31 1 1
BTRC -0.006 0 -10000 0 -10000 0 0
ROCK2 0.071 0.028 0.19 6 -10000 0 6
TUBG1 0.052 0.023 0.1 42 -10000 0 42
G2/M transition of mitotic cell cycle 0.26 0.072 0.27 535 -10000 0 535
MLF1IP 0.007 0.042 0.21 24 -10000 0 24
INCENP 0.01 0.014 0.24 2 -10000 0 2
TCGA08_retinoblastoma

Figure S3.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S3.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CDKN2B -0.032 0.016 -10000 0 -10000 0 0
CDKN2C -0.002 0.059 0.24 28 -10000 0 28
CDKN2A 0.14 0.12 0.25 314 -10000 0 314
CCND2 -0.095 0.098 -10000 0 -0.18 304 304
RB1 0.098 0.095 0.18 307 -10000 0 307
CDK4 -0.092 0.093 -10000 0 -0.17 307 307
CDK6 -0.096 0.098 -10000 0 -0.19 259 259
G1/S progression -0.11 0.082 -10000 0 -0.18 308 308
PLK2 and PLK4 events

Figure S4.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S4.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PLK2 0.029 0.094 0.24 86 -0.31 5 91
PLK4 0.1 0.12 0.24 251 -10000 0 251
regulation of centriole replication 0.12 0.13 0.23 301 -0.21 3 304
Aurora B signaling

Figure S5.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S5.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Condensin I complex 0.39 0.16 0.42 527 -10000 0 527
STMN1 0.11 0.16 0.29 209 -10000 0 209
Aurora B/RasGAP/Survivin 0.073 0.091 0.21 150 -0.16 1 151
Chromosomal passenger complex/Cul3 protein complex 0.015 0.11 0.22 77 -0.16 14 91
BIRC5 0.067 0.093 0.25 115 -10000 0 115
DES -0.061 0.15 -10000 0 -0.42 82 82
Aurora C/Aurora B/INCENP 0.054 0.057 0.16 120 -10000 0 120
Aurora B/TACC1 -0.1 0.093 0.15 15 -0.17 356 371
Aurora B/PP2A 0.045 0.063 0.17 119 -10000 0 119
mol:GTP 0 0 -10000 0 -10000 0 0
CBX5 0.018 0.038 0.17 8 -0.13 6 14
mitotic metaphase/anaphase transition -0.008 0.005 -10000 0 -10000 0 0
NDC80 0.24 0.13 0.27 506 -10000 0 506
Cul3 protein complex -0.05 0.09 0.16 7 -0.18 185 192
KIF2C 0.23 0.088 0.25 503 -10000 0 503
PEBP1 0.016 0.004 -10000 0 -10000 0 0
KIF20A 0.2 0.088 0.24 477 -10000 0 477
mol:GDP 0 0 -10000 0 -10000 0 0
Aurora B/RasGAP 0.044 0.065 0.17 118 -0.2 2 120
SEPT1 -0.006 0 -10000 0 -10000 0 0
SMC2 0.097 0.12 0.24 236 -10000 0 236
SMC4 0.23 0.053 0.24 542 -10000 0 542
NSUN2/NPM1/Nucleolin 0.059 0.11 0.28 111 -10000 0 111
PSMA3 -0.005 0.024 0.24 4 -0.31 1 5
G2/M transition of mitotic cell cycle -0.001 0.003 -10000 0 -10000 0 0
H3F3B 0.034 0.067 0.16 118 -0.23 6 124
AURKB 0.061 0.093 0.24 119 -10000 0 119
AURKC -0.006 0 -10000 0 -10000 0 0
CDCA8 0.055 0.082 0.25 84 -10000 0 84
cytokinesis 0.014 0.071 0.34 23 -10000 0 23
Aurora B/Septin1 0.069 0.14 0.39 91 -10000 0 91
AURKA 0.23 0.055 0.24 538 -10000 0 538
INCENP 0.023 0.015 0.25 2 -10000 0 2
KLHL13 -0.1 0.15 0.24 7 -0.31 183 190
BUB1 0.22 0.062 0.24 526 -10000 0 526
hSgo1/Aurora B/Survivin 0.15 0.098 0.2 420 -10000 0 420
EVI5 0.011 0.016 0.24 1 -0.28 1 2
RhoA/GTP 0.24 0.17 0.34 400 -10000 0 400
SGOL1 0.21 0.084 0.24 494 -10000 0 494
CENPA 0.21 0.092 0.23 527 -10000 0 527
NCAPG 0.22 0.063 0.24 530 -10000 0 530
Aurora B/HC8 Proteasome 0.046 0.065 0.17 123 -0.21 1 124
NCAPD2 0.12 0.12 0.24 295 -10000 0 295
Aurora B/PP1-gamma 0.05 0.071 0.18 130 -10000 0 130
RHOA -0.007 0.018 -10000 0 -0.31 2 2
NCAPH 0.15 0.12 0.24 354 -10000 0 354
NPM1 0 0 -10000 0 -10000 0 0
RASA1 -0.007 0.022 -10000 0 -0.31 3 3
KLHL9 -0.007 0.018 -10000 0 -0.31 2 2
mitotic prometaphase 0.012 0.004 -10000 0 -10000 0 0
proteasomal ubiquitin-dependent protein catabolic process 0.046 0.065 0.17 123 -0.21 1 124
PPP1CC 0.001 0.041 0.24 16 -10000 0 16
Centraspindlin 0.42 0.12 0.43 552 -10000 0 552
RhoA/GDP -0.004 0.012 -10000 0 -0.21 2 2
NSUN2 0.001 0.021 0.36 2 -10000 0 2
MYLK 0.014 0.091 0.16 103 -0.23 43 146
KIF23 0.24 0.044 0.25 550 -10000 0 550
VIM 0 0.11 0.2 83 -0.21 85 168
RACGAP1 0.22 0.083 0.25 488 -10000 0 488
mitosis 0 0 -10000 0 -10000 0 0
NCL 0 0 -10000 0 -10000 0 0
Chromosomal passenger complex 0.24 0.11 0.26 506 -10000 0 506
Chromosomal passenger complex/EVI5 0.008 0.024 0.19 4 -10000 0 4
TACC1 -0.25 0.12 -10000 0 -0.31 460 460
PPP2R5D -0.006 0 -10000 0 -10000 0 0
CUL3 -0.006 0 -10000 0 -10000 0 0
response to DNA damage stimulus 0 0 -10000 0 -10000 0 0
Circadian rhythm pathway

Figure S6.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S6.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
chromatin modification 0.31 0.2 0.48 301 -10000 0 301
CLOCK 0.023 0.045 0.25 13 -10000 0 13
TIMELESS/CRY2 0.16 0.18 0.37 254 -10000 0 254
DEC1/BMAL1 0.015 0.028 0.18 5 -10000 0 5
ATR 0.046 0.1 0.24 120 -10000 0 120
NR1D1 0.11 0.22 -10000 0 -0.9 13 13
ARNTL 0.02 0.036 0.26 5 -10000 0 5
TIMELESS 0.23 0.26 0.52 254 -10000 0 254
NPAS2 0.027 0.051 0.25 21 -10000 0 21
CRY2 -0.006 0 -10000 0 -10000 0 0
mol:CO -0.079 0.091 0.13 3 -0.18 254 257
CHEK1 0.23 0.059 0.24 534 -10000 0 534
mol:HEME 0.079 0.091 0.18 254 -0.13 3 257
PER1 -0.012 0.042 -10000 0 -0.31 11 11
BMAL/CLOCK/NPAS2 0.095 0.11 0.21 254 -10000 0 254
BMAL1/CLOCK 0.12 0.18 0.39 10 -0.56 13 23
S phase of mitotic cell cycle 0.31 0.2 0.48 301 -10000 0 301
TIMELESS/CHEK1/ATR 0.32 0.2 0.48 307 -10000 0 307
mol:NADPH 0.079 0.091 0.18 254 -0.13 3 257
PER1/TIMELESS 0.16 0.19 0.37 249 -10000 0 249
PER1-2 / CRY1-2 0 0 -10000 0 -10000 0 0
DEC1 -0.006 0 -10000 0 -10000 0 0
TCGA08_p53

Figure S7.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S7.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CDKN2A 0.11 0.1 0.2 314 -10000 0 314
TP53 0.019 0.079 0.15 1 -0.24 36 37
Senescence 0.003 0.098 0.16 2 -0.2 91 93
Apoptosis 0.003 0.098 0.16 2 -0.2 91 93
Activated_Oncogenes 0 0 -10000 0 -10000 0 0
MDM2 -0.075 0.067 0.22 1 -0.13 314 315
MDM4 0 0.038 0.24 14 -10000 0 14
Signaling events regulated by Ret tyrosine kinase

Figure S8.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S8.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PTK2 -0.02 0.052 -10000 0 -0.43 2 2
Crk/p130 Cas/Paxillin -0.19 0.1 -10000 0 -0.27 290 290
JUN -0.066 0.09 0.22 1 -0.29 2 3
HRAS -0.006 0 -10000 0 -10000 0 0
RET51/GFRalpha1/GDNF/GRB10 -0.06 0.09 0.29 1 -0.16 245 246
RAP1A -0.005 0.01 0.24 1 -10000 0 1
FRS2 0.001 0.04 0.24 15 -10000 0 15
RAP1A/GDP -0.003 0.007 0.17 1 -10000 0 1
RET51/GFRalpha1/GDNF/DOK1 -0.061 0.091 0.29 1 -0.16 246 247
EntrezGene:5979 0 0 -10000 0 -10000 0 0
PTPN11 -0.006 0 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
CRK -0.005 0.01 0.24 1 -10000 0 1
RET9/GFRalpha1/GDNF/Enigma -0.063 0.087 0.15 8 -0.16 249 257
RHOA -0.007 0.018 -10000 0 -0.31 2 2
RAP1A/GTP -0.066 0.07 0.12 10 -0.14 244 254
GRB7 -0.006 0.03 0.24 4 -0.31 3 7
RET51/GFRalpha1/GDNF -0.06 0.09 0.29 1 -0.16 245 246
MAPKKK cascade -0.079 0.081 -10000 0 -0.17 230 230
BCAR1 -0.006 0.013 -10000 0 -0.31 1 1
RET9/GFRalpha1/GDNF/IRS1 -0.16 0.11 0.15 7 -0.21 448 455
lamellipodium assembly -0.17 0.1 -10000 0 -0.26 287 287
RET51/GFRalpha1/GDNF/SHC -0.06 0.09 0.29 1 -0.16 245 246
PIK3CA 0.047 0.1 0.24 122 -10000 0 122
RET9/GFRalpha1/GDNF/SHC -0.062 0.086 0.15 8 -0.16 248 256
RET9/GFRalpha1/GDNF/Shank3 -0.062 0.086 0.15 8 -0.16 248 256
MAPK3 -0.068 0.072 0.22 1 -0.27 10 11
DOK1 -0.007 0.018 -10000 0 -0.31 2 2
DOK6 -0.006 0 -10000 0 -10000 0 0
PXN -0.01 0.033 -10000 0 -0.31 7 7
neurite development -0.071 0.079 0.22 1 -0.33 14 15
DOK5 0.066 0.14 0.24 193 -0.31 23 216
GFRA1 -0.13 0.16 0.24 8 -0.31 248 256
MAPK8 -0.07 0.094 0.2 1 -0.39 1 2
HRAS/GTP -0.071 0.099 0.24 1 -0.19 230 231
tube development -0.068 0.074 0.14 8 -0.15 248 256
MAPK1 -0.065 0.068 0.22 1 -0.27 1 2
RET9/GFRalpha1/GDNF/FRS2/SHP2/Grb2 -0.077 0.094 0.21 1 -0.18 241 242
Rac1/GDP -0.004 0.009 -10000 0 -0.21 1 1
SRC -0.006 0 -10000 0 -10000 0 0
PDLIM7 -0.007 0.018 -10000 0 -0.31 2 2
RET51/GFRalpha1/GDNF/Dok6 -0.056 0.086 0.28 1 -0.15 245 246
SHC1 -0.006 0 -10000 0 -10000 0 0
RET51/GFRalpha1/GDNF/Dok4 -0.06 0.09 0.29 1 -0.16 245 246
RET51/GFRalpha1/GDNF/Dok5 -0.02 0.12 0.29 1 -0.17 166 167
PRKCA -0.005 0.037 0.24 7 -0.31 4 11
HRAS/GDP -0.003 0 -10000 0 -10000 0 0
CREB1 -0.091 0.11 0.22 1 -0.22 230 231
PIK3R1 -0.075 0.13 -10000 0 -0.31 131 131
RET9/GFRalpha1/GDNF/SHC/GAB1/Grb2 -0.082 0.094 -10000 0 -0.19 248 248
RET51/GFRalpha1/GDNF/Grb7 -0.06 0.091 0.29 1 -0.16 245 246
mol:GDP 0 0 -10000 0 -10000 0 0
RET -0.003 0.027 0.24 7 -10000 0 7
DOK4 -0.006 0 -10000 0 -10000 0 0
JNK cascade -0.066 0.089 0.21 1 -0.29 2 3
RET9/GFRalpha1/GDNF/FRS2 -0.059 0.089 0.16 15 -0.16 241 256
SHANK3 -0.006 0 -10000 0 -10000 0 0
RASA1 -0.007 0.022 -10000 0 -0.31 3 3
NCK1 0.012 0.065 0.24 42 -10000 0 42
RET9/GFRalpha1/GDNF/SHC/Grb2/SOS1 -0.074 0.094 0.22 1 -0.18 233 234
RET51/GFRalpha1/GDNF/FRS2/SHP2/Grb2 -0.076 0.095 0.22 2 -0.18 238 240
RET51/GFRalpha1/GDNF/DOK/RasGAP/NCK -0.074 0.1 0.22 1 -0.41 1 2
RET51/GFRalpha1/GDNF/SHC/Grb2/SOS1 -0.073 0.095 0.21 2 -10000 0 2
PI3K -0.24 0.16 -10000 0 -0.38 272 272
SOS1 0.005 0.05 0.24 24 -10000 0 24
RET9/GFRalpha1/GDNF/Shank3/Grb2 -0.058 0.083 -10000 0 -0.15 248 248
GRB10 -0.006 0 -10000 0 -10000 0 0
activation of MAPKK activity -0.072 0.091 0.19 2 -10000 0 2
RET51/GFRalpha1/GDNF/FRS2 -0.057 0.093 0.29 2 -0.16 238 240
GAB1 -0.007 0.018 -10000 0 -0.31 2 2
IRS1 -0.2 0.15 -10000 0 -0.31 357 357
IRS2 -0.006 0 -10000 0 -10000 0 0
RET51/GFRalpha1/GDNF/SHC/GAB1/Grb2 -0.08 0.095 0.21 1 -0.19 245 246
RET51/GFRalpha1/GDNF/PKC alpha -0.06 0.094 0.29 1 -0.16 246 247
GRB2 -0.006 0 -10000 0 -10000 0 0
PRKACA -0.006 0 -10000 0 -10000 0 0
GDNF -0.006 0 -10000 0 -10000 0 0
RAC1 -0.006 0.013 -10000 0 -0.31 1 1
RET51/GFRalpha1/GDNF/IRS1 -0.16 0.12 0.29 1 -0.21 447 448
Rac1/GTP -0.2 0.12 -10000 0 -0.31 272 272
RET9/GFRalpha1/GDNF -0.071 0.093 0.15 8 -0.18 248 256
GFRalpha1/GDNF -0.094 0.11 0.17 8 -0.21 248 256
Osteopontin-mediated events

Figure S9.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S9.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
IKK alpha homodimer 0.088 0.16 0.29 184 -0.36 2 186
NF kappa B1 p50/RelA/I kappa B alpha 0.07 0.18 0.32 152 -0.3 14 166
alphaV/beta3 Integrin/Osteopontin/Src 0.079 0.11 0.21 219 -0.24 8 227
AP1 0.08 0.26 0.4 172 -0.35 42 214
ILK 0.063 0.15 0.27 126 -0.39 2 128
bone resorption -0.009 0.15 0.21 100 -0.28 50 150
PTK2B -0.006 0.013 -10000 0 -0.31 1 1
PYK2/p130Cas 0.06 0.14 0.25 125 -0.33 3 128
ITGAV 0.017 0.058 0.25 19 -0.31 3 22
mol:GTP 0 0 -10000 0 -10000 0 0
CD44/Rho Family GTPase/ROCK2 -0.09 0.1 0.17 2 -0.21 233 235
alphaV/beta3 Integrin/Osteopontin 0.056 0.14 0.2 244 -0.2 72 316
MAP3K1 0.062 0.15 0.27 125 -0.21 28 153
JUN 0.005 0.044 0.24 14 -0.31 2 16
MAPK3 0.11 0.21 0.39 182 -0.34 3 185
MAPK1 0.12 0.21 0.39 185 -0.36 2 187
Rac1/GDP -0.004 0.009 -10000 0 -0.21 1 1
NFKB1 -0.01 0.033 -10000 0 -0.31 7 7
MAPK8 0.064 0.15 0.29 125 -0.23 17 142
ITGB3 -0.024 0.12 0.26 12 -0.31 74 86
NFKBIA 0.11 0.22 0.39 183 -0.32 9 192
FOS -0.023 0.12 0.25 26 -0.31 65 91
CD44 -0.13 0.15 -10000 0 -0.31 236 236
CHUK 0.002 0.043 0.24 18 -10000 0 18
PLAU 0.17 0.3 0.6 178 -0.39 1 179
NF kappa B1 p50/RelA 0.082 0.19 0.37 150 -0.28 8 158
BCAR1 -0.006 0.013 -10000 0 -0.31 1 1
RELA -0.006 0.013 -10000 0 -0.31 1 1
alphaV beta3 Integrin -0.002 0.11 0.2 35 -0.22 75 110
mol:GDP 0 0 -10000 0 -10000 0 0
SYK 0.057 0.14 0.25 125 -0.2 19 144
VAV3 0.069 0.14 0.26 148 -0.36 2 150
MAP3K14 0.095 0.18 0.32 182 -0.39 2 184
ROCK2 -0.004 0.023 0.24 5 -10000 0 5
SPP1 0.089 0.13 0.26 202 -0.32 6 208
RAC1 -0.006 0.013 -10000 0 -0.31 1 1
Rac1/GTP 0.04 0.11 0.21 112 -0.34 2 114
MMP2 0.052 0.26 0.42 117 -0.4 56 173
Nongenotropic Androgen signaling

Figure S10.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S10.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PTK2 0.007 0.044 0.2 28 -10000 0 28
GNB1/GNG2 -0.089 0.082 -10000 0 -0.16 328 328
regulation of S phase of mitotic cell cycle -0.12 0.13 -10000 0 -0.22 319 319
GNAO1 -0.003 0.028 0.24 6 -0.31 1 7
HRAS -0.006 0.004 -10000 0 -10000 0 0
SHBG/T-DHT 0.003 0.002 -10000 0 -10000 0 0
PELP1 -0.006 0.004 -10000 0 -10000 0 0
AKT1 -0.003 0.009 0.2 1 -10000 0 1
MAP2K1 -0.085 0.087 0.2 13 -0.24 42 55
T-DHT/AR -0.12 0.1 -10000 0 -0.21 329 329
G-protein coupled receptor activity 0 0 -10000 0 -10000 0 0
mol:GTP 0 0.002 0.008 26 -0.005 65 91
GNAI2 -0.005 0.002 -10000 0 -10000 0 0
GNAI3 0.036 0.093 0.24 96 -10000 0 96
GNAI1 -0.005 0.041 0.24 8 -0.31 5 13
mol:GDP -0.2 0.17 -10000 0 -0.33 329 329
cell proliferation -0.12 0.17 0.3 23 -0.39 109 132
PIK3CA 0.047 0.1 0.24 122 -10000 0 122
FOS -0.11 0.25 0.44 26 -0.75 65 91
mol:Ca2+ -0.015 0.018 0.04 15 -0.049 37 52
MAPK3 -0.12 0.14 0.24 23 -0.32 109 132
MAPK1 -0.055 0.093 0.23 23 -0.25 46 69
PIK3R1 -0.075 0.13 -10000 0 -0.31 131 131
mol:IP3 0 0.003 0.011 26 -0.004 65 91
cAMP biosynthetic process 0.01 0.013 -10000 0 -10000 0 0
GNG2 -0.005 0.01 0.24 1 -10000 0 1
potassium channel inhibitor activity 0 0.003 0.011 26 -0.004 65 91
HRAS/GTP -0.086 0.075 0.13 13 -0.15 316 329
actin cytoskeleton reorganization -0.033 0.054 -10000 0 -0.14 107 107
SRC -0.006 0.004 -10000 0 -10000 0 0
voltage-gated calcium channel activity 0 0.003 0.011 26 -0.004 65 91
PI3K -0.003 0.099 0.15 98 -0.18 107 205
apoptosis 0.094 0.16 0.46 66 -0.33 26 92
T-DHT/AR/PELP1 -0.099 0.089 -10000 0 -0.18 329 329
HRAS/GDP -0.19 0.16 -10000 0 -0.32 325 325
CREB1 -0.11 0.16 0.4 10 -0.5 66 76
RAC1-CDC42/GTP -0.013 0.079 0.12 98 -0.14 107 205
AR -0.18 0.15 -10000 0 -0.31 329 329
GNB1 -0.006 0.013 -10000 0 -0.31 1 1
RAF1 -0.085 0.08 0.17 13 -0.22 42 55
RAC1-CDC42/GDP -0.19 0.16 -10000 0 -0.31 325 325
T-DHT/AR/PELP1/Src -0.089 0.083 -10000 0 -0.16 329 329
MAP2K2 -0.11 0.099 0.21 10 -0.26 90 100
T-DHT/AR/PELP1/Src/PI3K -0.12 0.13 -10000 0 -0.22 319 319
GNAZ -0.007 0.025 -10000 0 -0.31 4 4
SHBG -0.006 0 -10000 0 -10000 0 0
Gi family/GNB1/GNG2/GDP -0.032 0.061 0.19 1 -0.26 7 8
mol:T-DHT 0 0 -10000 0 -10000 0 0
RAC1 -0.006 0.013 -10000 0 -0.31 1 1
GNRH1 -0.003 0.001 -10000 0 -10000 0 0
Gi family/GTP -0.046 0.064 0.18 1 -0.23 8 9
CDC42 -0.006 0 -10000 0 -10000 0 0
BARD1 signaling events

Figure S11.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S11.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BARD1/CSTF1 0.02 0.065 0.18 83 -10000 0 83
ATM 0.002 0.043 0.24 18 -10000 0 18
UBE2D3 -0.006 0 -10000 0 -10000 0 0
PRKDC 0.036 0.093 0.24 97 -10000 0 97
ATR 0.046 0.1 0.24 120 -10000 0 120
UBE2L3 -0.006 0 -10000 0 -10000 0 0
FANCD2 0.11 0.12 0.34 92 -10000 0 92
protein ubiquitination 0.14 0.087 0.26 169 -10000 0 169
XRCC5 0.008 0.056 0.24 31 -10000 0 31
XRCC6 -0.006 0 -10000 0 -10000 0 0
M/R/N Complex 0.034 0.057 0.16 99 -0.18 2 101
MRE11A 0.025 0.081 0.24 70 -10000 0 70
DNA-PK 0.038 0.059 0.16 114 -10000 0 114
FA complex/FANCD2/Ubiquitin 0.004 0.03 0.28 5 -10000 0 5
FANCF -0.006 0 -10000 0 -10000 0 0
BRCA1 0.009 0.058 0.24 33 -10000 0 33
CCNE1 0.22 0.073 0.24 515 -10000 0 515
CDK2/Cyclin E1 0.22 0.1 0.24 535 -10000 0 535
FANCG -0.005 0.01 0.24 1 -10000 0 1
BRCA1/BACH1/BARD1 0.029 0.081 0.2 100 -10000 0 100
FANCE -0.006 0 -10000 0 -10000 0 0
FANCC -0.004 0.023 0.24 5 -10000 0 5
NBN 0.015 0.071 0.24 49 -0.31 1 50
FANCA 0.003 0.046 0.24 20 -10000 0 20
DNA repair 0.19 0.17 0.32 296 -10000 0 296
BRCA1/BARD1/ubiquitin 0.029 0.081 0.2 100 -10000 0 100
BARD1/DNA-PK 0.057 0.081 0.18 158 -10000 0 158
FANCL 0.011 0.062 0.24 38 -10000 0 38
mRNA polyadenylation -0.019 0.065 -10000 0 -0.17 83 83
BRCA1/BARD1/CTIP/M/R/N Complex 0.048 0.087 0.23 75 -10000 0 75
BRCA1/BACH1/BARD1/TopBP1 0.085 0.075 0.16 297 -10000 0 297
BRCA1/BARD1/P53 0.033 0.1 0.18 140 -0.16 56 196
BARD1/CSTF1/BRCA1 0.031 0.053 0.16 86 -10000 0 86
BRCA1/BACH1 0.009 0.058 0.24 33 -10000 0 33
BARD1 0.029 0.087 0.24 81 -10000 0 81
PCNA 0.052 0.1 0.24 133 -10000 0 133
BRCA1/BARD1/UbcH5C 0.031 0.053 0.16 86 -10000 0 86
BRCA1/BARD1/UbcH7 0.031 0.053 0.16 86 -10000 0 86
BRCA1/BARD1/RAD51/PCNA 0.11 0.11 0.2 285 -10000 0 285
BARD1/DNA-PK/P53 0.035 0.1 0.31 32 -0.15 55 87
BRCA1/BARD1/Ubiquitin 0.029 0.081 0.2 100 -10000 0 100
BRCA1/BARD1/CTIP 0.04 0.093 0.21 100 -10000 0 100
FA complex 0.028 0.054 0.23 14 -10000 0 14
BARD1/EWS 0.018 0.062 0.17 81 -10000 0 81
RBBP8 0.02 0.071 0.2 74 -10000 0 74
TP53 -0.051 0.11 0.24 1 -0.31 85 86
TOPBP1 0.16 0.12 0.24 369 -10000 0 369
G1/S transition of mitotic cell cycle -0.032 0.098 0.16 56 -0.17 140 196
BRCA1/BARD1 0.2 0.11 0.31 231 -10000 0 231
CSTF1 -0.004 0.021 0.24 4 -10000 0 4
BARD1/EWS-Fli1 0.021 0.06 0.17 81 -10000 0 81
CDK2 0.094 0.12 0.24 229 -10000 0 229
UniProt:Q9BZD1 0 0 -10000 0 -10000 0 0
RAD51 0.12 0.12 0.24 290 -10000 0 290
RAD50 -0.005 0.019 0.24 2 -0.31 1 3
BRCA1/BARD1/DNA-directed RNA polymerase II holoenzyme 0.029 0.081 0.2 100 -10000 0 100
EWSR1 -0.006 0 -10000 0 -10000 0 0
Aurora A signaling

Figure S12.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S12.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Aurora A/GADD45A 0.11 0.055 0.27 48 -10000 0 48
BIRC5 0.044 0.099 0.24 115 -10000 0 115
NFKBIA 0.11 0.033 -10000 0 -10000 0 0
CPEB1 -0.006 0 -10000 0 -10000 0 0
AKT1 0.11 0.03 0.31 1 -10000 0 1
NDEL1 -0.006 0 -10000 0 -10000 0 0
Aurora A/BRCA1 0.014 0.057 0.24 33 -10000 0 33
NDEL1/TACC3 0.14 0.077 0.23 245 -10000 0 245
GADD45A 0.015 0.069 0.24 48 -10000 0 48
GSK3B 0.004 0.005 -10000 0 -10000 0 0
PAK1/Aurora A 0.1 0.04 0.28 18 -10000 0 18
MDM2 -0.006 0.023 0.24 2 -0.31 2 4
JUB 0.006 0.054 0.24 28 -10000 0 28
TPX2 0.19 0.031 0.2 556 -10000 0 556
TP53 0.072 0.053 0.24 3 -0.37 3 6
DLG7 0.29 0.064 0.3 537 -10000 0 537
AURKAIP1 -0.008 0.028 -10000 0 -0.31 5 5
ARHGEF7 -0.005 0.01 0.24 1 -10000 0 1
G2 phase of mitotic cell cycle 0 0 -10000 0 -10000 0 0
Aurora A/NDEL1/TACC3 0.15 0.081 0.24 245 -10000 0 245
G2/M transition of mitotic cell cycle 0.014 0.056 0.24 33 -10000 0 33
AURKA 0.14 0.036 0.15 523 -10000 0 523
AURKB 0.062 0.046 0.15 118 -10000 0 118
CDC25B 0.11 0.035 0.19 35 -10000 0 35
G2/M transition checkpoint 0.012 0.052 0.24 28 -10000 0 28
mRNA polyadenylation 0 0.001 -10000 0 -10000 0 0
Aurora A/CPEB 0 0.001 -10000 0 -10000 0 0
Aurora A/TACC1/TRAP/chTOG -0.01 0.082 0.24 34 -0.2 1 35
BRCA1 0.009 0.058 0.24 33 -10000 0 33
centrosome duplication 0.1 0.04 0.27 18 -10000 0 18
regulation of centrosome cycle 0.14 0.081 0.22 245 -10000 0 245
spindle assembly -0.011 0.081 0.23 34 -0.2 1 35
TDRD7 -0.002 0.036 0.24 11 -0.31 1 12
Aurora A/RasGAP/Survivin 0.12 0.069 0.23 136 -10000 0 136
CENPA 0.076 0.035 0.13 122 -10000 0 122
Aurora A/PP2A 0.097 0.025 -10000 0 -10000 0 0
meiosis 0 0 -10000 0 -10000 0 0
protein catabolic process 0.15 0.085 0.2 439 -0.28 1 440
negative regulation of DNA binding 0.073 0.053 0.24 3 -0.33 4 7
prophase 0 0 -10000 0 -10000 0 0
GIT1/beta-PIX -0.006 0.01 0.17 2 -10000 0 2
RASA1 -0.007 0.022 -10000 0 -0.31 3 3
Ajuba/Aurora A 0.012 0.053 0.24 28 -10000 0 28
mitotic prometaphase 0.001 0.001 -10000 0 -10000 0 0
proteasomal ubiquitin-dependent protein catabolic process 0.14 0.036 0.15 523 -10000 0 523
TACC1 -0.25 0.12 -10000 0 -0.31 460 460
TACC3 0.1 0.12 0.24 245 -10000 0 245
Aurora A/Antizyme1 0.056 0.057 -10000 0 -0.21 3 3
Aurora A/RasGAP 0.096 0.026 -10000 0 -10000 0 0
OAZ1 -0.1 0.14 -10000 0 -0.31 181 181
RAN -0.006 0 -10000 0 -10000 0 0
mitosis 0 0 -10000 0 -10000 0 0
PRKACA 0.004 0.005 -10000 0 -10000 0 0
GIT1 -0.005 0.01 0.24 1 -10000 0 1
GIT1/beta-PIX/PAK1 0.014 0.027 0.16 20 -10000 0 20
Importin alpha/Importin beta/TPX2 0.19 0.031 0.2 556 -10000 0 556
PPP2R5D -0.006 0 -10000 0 -10000 0 0
Aurora A/TPX2 0.24 0.04 0.24 556 -10000 0 556
PAK1 0.002 0.043 0.24 18 -10000 0 18
CKAP5 0.072 0.12 0.24 179 -10000 0 179
HIF-1-alpha transcription factor network

Figure S13.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S13.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PKM2 0.22 0.43 0.79 120 -0.9 6 126
HDAC7 0.01 0.035 0.16 15 -10000 0 15
HIF1A/ARNT/Cbp/p300/Src-1 0.024 0.3 0.8 39 -0.78 2 41
SMAD4 -0.007 0.002 -10000 0 -10000 0 0
ID2 0.22 0.43 0.78 129 -0.9 6 135
AP1 -0.015 0.092 0.2 44 -0.21 65 109
ABCG2 0.21 0.44 0.79 114 -0.87 8 122
HIF1A 0.081 0.14 0.29 121 -0.41 1 122
TFF3 0.005 0.38 0.85 43 -0.86 17 60
GATA2 -0.006 0.039 0.16 9 -0.31 6 15
AKT1 0.098 0.15 0.33 117 -10000 0 117
response to hypoxia 0.071 0.15 0.31 131 -10000 0 131
MCL1 0.22 0.43 0.79 120 -0.9 6 126
NDRG1 0.24 0.45 0.83 123 -0.92 7 130
SERPINE1 0.25 0.46 0.84 136 -0.9 6 142
FECH 0.22 0.43 0.79 120 -0.9 6 126
FURIN 0.22 0.43 0.79 120 -0.9 6 126
NCOA2 -0.005 0.015 0.24 2 -10000 0 2
EP300 0.19 0.25 0.52 159 -0.29 1 160
HMOX1 0.22 0.44 0.78 128 -0.9 7 135
BHLHE40 0.18 0.43 0.76 141 -0.9 6 147
BHLHE41 0.18 0.43 0.76 141 -0.9 6 147
HIF1A/ARNT/SMAD3/SMAD4/SP1 0.017 0.12 0.39 32 -0.28 1 33
ENG 0.1 0.15 0.35 60 -0.31 1 61
JUN 0.001 0.043 0.25 14 -0.31 1 15
RORA 0.22 0.43 0.79 120 -0.9 6 126
ABCB1 -0.022 0.073 0.69 3 -10000 0 3
TFRC 0.29 0.48 0.88 151 -0.9 6 157
CXCR4 0.22 0.44 0.8 120 -0.92 6 126
TF 0.23 0.44 0.79 130 -0.9 6 136
CITED2 0.22 0.44 0.79 118 -0.92 8 126
HIF1A/ARNT -0.027 0.31 1 18 -1 6 24
LDHA 0.082 0.25 0.66 86 -10000 0 86
ETS1 0.23 0.44 0.8 122 -0.9 6 128
PGK1 0.3 0.49 0.92 147 -0.9 6 153
NOS2 0.18 0.43 0.76 141 -0.9 6 147
ITGB2 0.22 0.43 0.79 119 -0.89 7 126
ALDOA 0.22 0.43 0.79 120 -0.9 6 126
Cbp/p300/CITED2 0.16 0.44 0.79 127 -0.93 7 134
FOS -0.027 0.11 0.24 26 -0.31 64 90
HK2 0.22 0.43 0.79 120 -0.9 6 126
SP1 -0.006 0.018 0.21 4 -10000 0 4
GCK 0.23 0.3 0.72 103 -10000 0 103
HK1 0.22 0.43 0.79 120 -0.9 6 126
NPM1 0.22 0.43 0.79 120 -0.9 6 126
EGLN1 0.22 0.43 0.79 120 -0.9 6 126
CREB1 0.046 0.096 0.22 131 -10000 0 131
PGM1 0.24 0.45 0.84 125 -0.9 6 131
SMAD3 -0.008 0.018 -10000 0 -0.31 2 2
EDN1 0.14 0.22 0.66 33 -1.2 1 34
IGFBP1 0.22 0.43 0.79 120 -0.9 6 126
VEGFA 0.26 0.41 0.79 137 -0.68 2 139
HIF1A/JAB1 0.004 0.062 0.24 22 -0.29 1 23
CP 0.32 0.49 0.9 160 -0.89 11 171
CXCL12 0.19 0.44 0.8 109 -0.88 11 120
COPS5 0.014 0.068 0.24 46 -10000 0 46
SMAD3/SMAD4 -0.009 0.013 -10000 0 -0.21 2 2
BNIP3 0.24 0.45 0.84 123 -0.9 6 129
EGLN3 0.24 0.46 0.83 130 -0.89 9 139
CA9 0.25 0.46 0.85 130 -0.9 6 136
TERT 0.22 0.43 0.79 120 -0.9 6 126
ENO1 0.22 0.43 0.79 120 -0.9 6 126
PFKL 0.22 0.43 0.79 120 -0.9 6 126
NCOA1 -0.007 0.018 -10000 0 -0.31 2 2
ADM 0.24 0.46 0.86 123 -0.9 6 129
ARNT 0.082 0.14 0.29 123 -10000 0 123
HNF4A -0.006 0 -10000 0 -10000 0 0
ADFP 0.29 0.49 0.91 148 -0.93 5 153
SLC2A1 0.26 0.41 0.8 134 -0.68 2 136
LEP 0.22 0.43 0.79 120 -0.9 6 126
HIF1A/ARNT/Cbp/p300 0.031 0.32 0.85 42 -0.8 2 44
EPO 0.22 0.35 0.73 99 -0.66 1 100
CREBBP 0.18 0.25 0.53 154 -0.33 1 155
HIF1A/ARNT/Cbp/p300/HDAC7 0.017 0.28 0.75 38 -0.69 5 43
PFKFB3 0.21 0.44 0.79 118 -0.89 10 128
NT5E 0.24 0.47 0.85 132 -0.89 12 144
IL2 signaling events mediated by STAT5

Figure S14.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S14.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
GAB2 -0.006 0.061 0.24 15 -0.31 13 28
ELF1 -0.008 0.032 0.18 6 -0.31 4 10
CCNA2 0.21 0.084 0.24 494 -10000 0 494
PIK3CA 0.047 0.1 0.24 122 -10000 0 122
JAK3 -0.006 0 -10000 0 -10000 0 0
PIK3R1 -0.075 0.13 -10000 0 -0.31 131 131
JAK1 -0.007 0.018 -10000 0 -0.31 2 2
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GAB2/GRB2/SOS1/SHP2/PI3K -0.019 0.086 0.25 2 -0.28 9 11
SHC1 -0.006 0 -10000 0 -10000 0 0
SP1 -0.22 0.13 0.18 8 -0.29 428 436
IL2RA -0.004 0.046 0.41 6 -10000 0 6
IL2RB -0.006 0.021 0.24 1 -0.31 2 3
SOS1 0.005 0.05 0.24 24 -10000 0 24
IL2RG -0.009 0.09 0.24 30 -0.31 30 60
G1/S transition of mitotic cell cycle -0.32 0.26 0.33 13 -0.46 428 441
PTPN11 -0.006 0 -10000 0 -10000 0 0
CCND2 -0.42 0.26 0.41 8 -0.56 428 436
LCK -0.006 0 -10000 0 -10000 0 0
GRB2 -0.006 0 -10000 0 -10000 0 0
IL2 -0.006 0 -10000 0 -10000 0 0
CDK6 -0.002 0.043 0.24 13 -0.31 3 16
CCND3 -0.018 0.078 -10000 0 -10000 0 0
mTOR signaling pathway

Figure S15.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S15.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
GBL -0.006 0 -10000 0 -10000 0 0
MKNK1 -0.006 0 -10000 0 -10000 0 0
mol:PIP3 -0.15 0.13 0.18 1 -0.26 277 278
FRAP1 -0.021 0.035 -10000 0 -10000 0 0
AKT1 -0.13 0.11 0.16 1 -0.23 277 278
INSR -0.034 0.088 -10000 0 -0.31 53 53
Insulin Receptor/Insulin -0.018 0.051 -10000 0 -0.18 53 53
mol:GTP -0.11 0.093 -10000 0 -0.19 266 266
eIF4E/eIF4G1/eIF4A1/eIF4B/RNA/eIF3/40s Ribosomal subunit -0.049 0.037 -10000 0 -0.14 1 1
TSC2 -0.006 0 -10000 0 -10000 0 0
RHEB/GDP -0.1 0.076 -10000 0 -0.17 266 266
TSC1 -0.006 0.013 -10000 0 -0.31 1 1
Insulin Receptor/IRS1 -0.18 0.15 -10000 0 -0.29 357 357
eIF4E/eIF4G1/eIF4A1/eIF4B/RNA -0.054 0.041 -10000 0 -0.16 1 1
mol:GDP 0 0 -10000 0 -10000 0 0
EIF3A -0.006 0 -10000 0 -10000 0 0
RPS6KB1 -0.065 0.069 0.18 1 -10000 0 1
MAP3K5 0.001 0.022 0.23 2 -0.29 2 4
PIK3R1 -0.073 0.13 -10000 0 -0.31 131 131
apoptosis 0.001 0.022 0.23 2 -0.29 2 4
mol:LY294002 -0.001 0.001 -10000 0 -0.001 357 357
EIF4B -0.061 0.063 0.17 1 -0.2 1 2
40S S6 ribosomal protein /40s Ribosomal subunit/eIF3 -0.059 0.059 -10000 0 -10000 0 0
eIF4E/eIF4G1/eIF4A1 -0.024 0.021 -10000 0 -10000 0 0
KIAA1303 -0.006 0 -10000 0 -10000 0 0
PI3K -0.16 0.14 0.15 27 -0.24 404 431
mTOR/RHEB/GTP/Raptor/GBL -0.039 0.051 -10000 0 -10000 0 0
FKBP1A -0.004 0.005 -10000 0 -10000 0 0
RHEB/GTP -0.098 0.078 0.12 6 -0.17 266 272
mol:Amino Acids -0.001 0.001 -10000 0 -0.001 357 357
FKBP12/Rapamycin -0.002 0.004 -10000 0 -10000 0 0
PDPK1 -0.14 0.12 0.16 1 -0.24 277 278
EIF4E -0.006 0 -10000 0 -10000 0 0
ASK1/PP5C -0.011 0.042 -10000 0 -0.57 2 2
mTOR/RHEB/GTP/Raptor/GBL/eIF4E 0.009 0.028 -10000 0 -10000 0 0
TSC1/TSC2 -0.12 0.1 0.15 1 -0.2 266 267
tumor necrosis factor receptor activity 0.001 0.001 0.001 357 -10000 0 357
RPS6 -0.006 0 -10000 0 -10000 0 0
PPP5C -0.005 0.01 0.24 1 -10000 0 1
EIF4G1 -0.006 0 -10000 0 -10000 0 0
IRS1 -0.18 0.14 -10000 0 -0.29 357 357
INS -0.006 0 -10000 0 -10000 0 0
PTEN -0.009 0.042 -10000 0 -0.31 11 11
PDK2 -0.14 0.12 0.16 1 -0.24 277 278
EIF4EBP1 0.006 0.01 -10000 0 -10000 0 0
PIK3CA 0.047 0.1 0.24 122 -10000 0 122
PPP2R5D -0.021 0.032 -10000 0 -10000 0 0
peptide biosynthetic process -0.025 0.05 -10000 0 -0.16 67 67
RHEB 0.005 0.052 0.24 26 -10000 0 26
EIF4A1 -0.006 0 -10000 0 -10000 0 0
mol:Rapamycin 0 0.001 0.002 11 -10000 0 11
EEF2 -0.026 0.05 -10000 0 -0.16 67 67
eIF4E/4E-BP1 0.008 0.007 -10000 0 -10000 0 0
Insulin Pathway

Figure S16.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S16.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CBL/APS/CAP -0.11 0.083 -10000 0 -0.16 382 382
TC10/GTP -0.019 0.034 -10000 0 -0.14 41 41
Insulin Receptor/Insulin/IRS1/Shp2 -0.11 0.098 -10000 0 -0.18 368 368
HRAS -0.006 0 -10000 0 -10000 0 0
APS homodimer 0 0 -10000 0 -10000 0 0
GRB14 0.006 0.052 0.24 26 -10000 0 26
FOXO3 -0.033 0.084 -10000 0 -0.71 8 8
AKT1 -0.1 0.097 0.21 2 -0.26 85 87
INSR -0.036 0.088 -10000 0 -0.31 53 53
Insulin Receptor/Insulin -0.024 0.04 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
GRB10 -0.006 0 -10000 0 -10000 0 0
SORBS1 -0.028 0.078 -10000 0 -0.31 41 41
CRK -0.005 0.01 0.24 1 -10000 0 1
PTPN1 -0.023 0.039 -10000 0 -10000 0 0
CAV1 -0.13 0.098 0.15 2 -0.19 400 402
CBL/APS/CAP/Crk-II/C3G -0.001 0.042 0.14 1 -0.15 41 42
Insulin Receptor/Insulin/IRS1/NCK2 -0.11 0.098 -10000 0 -0.18 368 368
mol:GDP 0 0 -10000 0 -10000 0 0
mol:PI-3-4-5-P3 -0.12 0.096 -10000 0 -0.18 346 346
Insulin Receptor/Insuli/IRS1/GRB2/SHC/PTP1B -0.13 0.14 -10000 0 -0.52 53 53
RPS6KB1 -0.093 0.093 0.2 3 -0.25 84 87
PARD6A -0.006 0.013 -10000 0 -0.31 1 1
CBL -0.006 0 -10000 0 -10000 0 0
tumor necrosis factor-mediated signaling pathway 0 0 -10000 0 -10000 0 0
DOK1 0.003 0.041 -10000 0 -0.69 2 2
PIK3R1 -0.075 0.13 -10000 0 -0.31 131 131
Insulin Receptor/Insuli/IRS1/GRB2/Shc -0.1 0.083 -10000 0 -0.26 84 84
HRAS/GTP -0.096 0.07 -10000 0 -0.15 354 354
Insulin Receptor -0.036 0.088 -10000 0 -0.31 53 53
Insulin Receptor/Insuli/IRS1/GRB2/SHC -0.1 0.093 -10000 0 -0.17 368 368
PRKCI 0.037 0.083 0.25 1 -10000 0 1
Insulin Receptor/Insulin/GRB14/PDK1 -0.11 0.091 -10000 0 -0.18 335 335
SHC1 -0.006 0 -10000 0 -10000 0 0
negative regulation of MAPKKK cascade 0.018 0.054 -10000 0 -0.6 2 2
PI3K -0.11 0.11 -10000 0 -0.19 339 339
NCK2 -0.006 0 -10000 0 -10000 0 0
RHOQ -0.004 0.018 0.24 3 -10000 0 3
mol:H2O2 -0.004 0.006 -10000 0 -10000 0 0
HRAS/GDP -0.003 0 -10000 0 -10000 0 0
AKT2 -0.099 0.098 0.21 2 -0.26 85 87
PRKCZ -0.034 0.03 -10000 0 -10000 0 0
SH2B2 0 0 -10000 0 -10000 0 0
SHC/SHIP -0.1 0.077 -10000 0 -0.16 368 368
F2RL2 -0.005 0.01 0.24 1 -10000 0 1
TRIP10 -0.006 0 -10000 0 -10000 0 0
Insulin Receptor/Insulin/Shc -0.007 0.046 -10000 0 -0.15 53 53
TC10/GTP/CIP4/Exocyst 0.007 0.011 0.15 3 -10000 0 3
Insulin Receptor/Insulin/SHC/GRB2/Sos1 0.004 0.053 -10000 0 -0.14 51 51
RAPGEF1 -0.006 0 -10000 0 -10000 0 0
RASA1 -0.007 0.022 -10000 0 -0.31 3 3
NCK1 0.012 0.065 0.24 42 -10000 0 42
CBL/APS/CAP/Crk-II -0.003 0.044 0.15 1 -0.16 41 42
TC10/GDP -0.003 0.012 0.17 3 -10000 0 3
Insulin Receptor/Insulin/SHC/GRB10 -0.004 0.048 -10000 0 -0.15 53 53
INPP5D -0.11 0.082 -10000 0 -0.16 368 368
SOS1 0.005 0.05 0.24 24 -10000 0 24
SGK1 -0.012 0.009 -10000 0 -10000 0 0
mol:cAMP 0 0 -10000 0 -10000 0 0
PTPN11 -0.006 0 -10000 0 -10000 0 0
IRS1 -0.2 0.15 -10000 0 -0.31 357 357
p62DOK/RasGAP 0.018 0.055 -10000 0 -0.6 2 2
INS -0.009 0.006 -10000 0 -10000 0 0
mol:PI-3-4-P2 -0.11 0.081 -10000 0 -0.16 368 368
GRB2 -0.006 0 -10000 0 -10000 0 0
EIF4EBP1 -0.095 0.091 0.2 2 -0.25 85 87
PTPRA -0.009 0.006 -10000 0 -10000 0 0
PIK3CA 0.047 0.1 0.24 122 -10000 0 122
TC10/GTP/CIP4 0.007 0.011 0.15 3 -10000 0 3
PDPK1 -0.006 0 -10000 0 -10000 0 0
Insulin Receptor/Insuli/IRS1/GRB2/SHC/Sos -0.12 0.11 -10000 0 -0.2 354 354
Insulin Receptor/Insulin/IRS1 -0.11 0.096 -10000 0 -0.18 368 368
Insulin Receptor/Insulin/IRS3 -0.028 0.06 -10000 0 -0.22 53 53
Par3/Par6 0.011 0.013 -10000 0 -0.15 1 1
S1P3 pathway

Figure S17.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S17.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PDGFRB -0.01 0.033 -10000 0 -0.31 7 7
mol:S1P -0.017 0.016 0.054 4 -0.03 323 327
S1P1/S1P/Gi -0.048 0.081 0.21 5 -0.3 9 14
GNAO1 -0.023 0.035 0.24 6 -0.31 1 7
S1P/S1P3/G12/G13 -0.018 0.024 -10000 0 -0.16 1 1
AKT1 -0.053 0.078 0.21 2 -0.51 7 9
AKT3 -0.56 0.52 0.55 4 -1 323 327
mol:GTP 0 0 -10000 0 -10000 0 0
PDGFB-D/PDGFRB -0.01 0.033 -10000 0 -0.31 7 7
GNAI2 -0.025 0.019 -10000 0 -10000 0 0
GNAI3 0.02 0.095 0.23 96 -10000 0 96
GNAI1 -0.022 0.044 0.22 8 -0.33 5 13
mol:GDP 0 0 -10000 0 -10000 0 0
S1PR3 -0.019 0.019 0.066 4 -0.035 323 327
S1PR2 0 0 -10000 0 -10000 0 0
EDG1 -0.009 0.031 -10000 0 -0.31 6 6
mol:Ca2+ -0.12 0.14 0.31 5 -0.25 269 274
MAPK3 -0.12 0.13 0.31 4 -0.25 275 279
MAPK1 -0.12 0.13 0.31 4 -0.24 269 273
JAK2 -0.12 0.13 0.3 4 -0.25 268 272
CXCR4 -0.12 0.13 0.31 4 -0.24 268 272
FLT1 -0.03 0.024 -10000 0 -10000 0 0
RhoA/GDP -0.004 0.012 -10000 0 -0.21 2 2
Rac1/GDP -0.004 0.009 -10000 0 -0.21 1 1
SRC -0.12 0.13 0.31 4 -0.24 269 273
S1P/S1P3/Gi -0.12 0.14 0.32 5 -0.25 269 274
RAC1 -0.006 0.013 -10000 0 -0.31 1 1
RhoA/GTP -0.12 0.12 0.28 4 -0.23 269 273
VEGFA -0.008 0.071 0.21 49 -10000 0 49
S1P/S1P2/Gi -0.067 0.09 0.23 5 -0.27 9 14
VEGFR1 homodimer/VEGFA homodimer -0.032 0.057 0.18 26 -10000 0 26
RHOA -0.007 0.018 -10000 0 -0.31 2 2
S1P/S1P3/Gq -0.039 0.066 -10000 0 -0.22 59 59
GNAQ -0.012 0.043 -10000 0 -0.31 12 12
GNAZ -0.025 0.031 -10000 0 -0.33 4 4
G12/G13 -0.007 0.009 -10000 0 -0.21 1 1
GNA14 -0.005 0.015 0.24 2 -10000 0 2
GNA15 -0.006 0.016 0.24 1 -0.31 1 2
GNA12 -0.006 0 -10000 0 -10000 0 0
GNA13 -0.006 0.013 -10000 0 -0.31 1 1
GNA11 -0.034 0.088 -10000 0 -0.31 53 53
Rac1/GTP -0.12 0.12 0.28 4 -0.23 269 273
IGF1 pathway

Figure S18.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S18.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
NCK2 -0.006 0 -10000 0 -10000 0 0
PTK2 0.006 0.054 0.24 28 -10000 0 28
CRKL -0.1 0.098 -10000 0 -0.26 140 140
GRB2/SOS1/SHC 0.015 0.03 0.16 24 -10000 0 24
HRAS -0.006 0 -10000 0 -10000 0 0
IRS1/Crk -0.1 0.099 -10000 0 -0.26 140 140
IGF-1R heterotetramer/IGF1/PTP1B -0.06 0.085 -10000 0 -0.2 140 140
AKT1 -0.096 0.11 -10000 0 -0.24 155 155
BAD -0.093 0.1 -10000 0 -0.24 141 141
mol:GTP 0 0 -10000 0 -10000 0 0
CRK -0.1 0.099 -10000 0 -0.26 140 140
IGF-1R heterotetramer/IGF1/IRS1/Shp2 -0.1 0.099 0.12 3 -0.26 140 143
RAF1 -0.086 0.1 -10000 0 -0.31 31 31
IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos -0.086 0.1 0.14 6 -0.24 138 144
YWHAZ -0.006 0 -10000 0 -10000 0 0
IGF-1R heterotetramer/IGF1/IRS1 -0.1 0.11 0.12 3 -0.28 140 143
PIK3CA 0.047 0.1 0.24 122 -10000 0 122
RPS6KB1 -0.094 0.11 0.2 2 -0.25 139 141
GNB2L1 -0.006 0 -10000 0 -10000 0 0
positive regulation of MAPKKK cascade -0.077 0.09 -10000 0 -0.27 31 31
PXN -0.01 0.033 -10000 0 -0.31 7 7
PIK3R1 -0.075 0.13 -10000 0 -0.31 131 131
cell adhesion 0 0 -10000 0 -10000 0 0
GRB2/SOS1 0.001 0.036 0.17 24 -10000 0 24
HRAS/GTP -0.09 0.085 -10000 0 -0.23 138 138
IGF-1R heterotetramer/IGF1/GRB2/Sos/Shc -0.041 0.077 0.16 12 -0.16 134 146
IGF-1R heterotetramer -0.086 0.13 -10000 0 -0.36 107 107
IGF-1R heterotetramer/IGF1/IRS/Nck -0.096 0.1 -10000 0 -0.26 140 140
Crk/p130 Cas/Paxillin -0.097 0.092 -10000 0 -0.24 145 145
IGF1R -0.086 0.13 -10000 0 -0.36 107 107
IGF1 -0.039 0.056 0.21 3 -0.36 11 14
IRS2/Crk -0.097 0.094 -10000 0 -0.25 140 140
PI3K -0.097 0.13 0.14 25 -0.23 213 238
apoptosis 0.085 0.094 0.22 140 -10000 0 140
HRAS/GDP -0.003 0 -10000 0 -10000 0 0
PRKCD -0.096 0.12 -10000 0 -0.29 135 135
RAF1/14-3-3 E -0.078 0.091 -10000 0 -0.27 31 31
BAD/14-3-3 -0.089 0.099 -10000 0 -0.23 140 140
PRKCZ -0.096 0.11 -10000 0 -0.24 155 155
Crk/p130 Cas/Paxillin/FAK1 -0.097 0.091 -10000 0 -0.24 135 135
PTPN1 -0.006 0 -10000 0 -10000 0 0
IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos/Shc/RACK1 -0.099 0.12 -10000 0 -0.3 138 138
BCAR1 -0.006 0.013 -10000 0 -0.31 1 1
IGF-1R heterotetramer/IGF1/SHC/GRB10 -0.052 0.075 -10000 0 -0.18 140 140
mol:GDP 0 0 -10000 0 -10000 0 0
SOS1 0.005 0.05 0.24 24 -10000 0 24
IRS1/NCK2 -0.1 0.098 -10000 0 -0.26 140 140
GRB10 -0.006 0 -10000 0 -10000 0 0
PTPN11 -0.1 0.098 -10000 0 -0.26 140 140
IRS1 -0.069 0.12 0.1 3 -0.28 140 143
IRS2 -0.1 0.098 -10000 0 -0.26 140 140
IGF-1R heterotetramer/IGF1 -0.086 0.11 0.14 3 -0.27 140 143
GRB2 -0.006 0 -10000 0 -10000 0 0
PDPK1 -0.099 0.12 -10000 0 -0.22 213 213
YWHAE -0.006 0.013 -10000 0 -0.31 1 1
PRKD1 -0.096 0.12 -10000 0 -0.29 137 137
SHC1 -0.006 0 -10000 0 -10000 0 0
TCGA08_rtk_signaling

Figure S19.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S19.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PDGFRA -0.041 0.11 0.24 9 -0.31 74 83
HRAS -0.006 0 -10000 0 -10000 0 0
EGFR -0.03 0.083 0.24 1 -0.31 46 47
AKT -0.054 0.12 0.2 30 -0.22 119 149
FOXO3 -0.01 0.036 -10000 0 -0.31 8 8
AKT1 -0.005 0.01 0.24 1 -10000 0 1
FOXO1 -0.009 0.031 -10000 0 -0.31 6 6
AKT3 -0.18 0.15 0.24 4 -0.31 323 327
FOXO4 -0.006 0 -10000 0 -10000 0 0
MET 0.014 0.089 0.24 59 -0.31 12 71
PIK3CA 0.047 0.1 0.24 122 -10000 0 122
PIK3CB 0.021 0.077 0.24 62 -10000 0 62
NRAS 0.12 0.12 0.24 300 -10000 0 300
PIK3CG 0.002 0.042 0.24 17 -10000 0 17
PIK3R3 0.083 0.12 0.24 203 -10000 0 203
PIK3R2 -0.005 0.01 0.24 1 -10000 0 1
NF1 -0.02 0.063 -10000 0 -0.31 26 26
RAS 0.051 0.087 0.19 77 -0.27 6 83
ERBB2 -0.005 0.029 0.24 5 -0.31 2 7
proliferation/survival/translation 0.064 0.11 0.22 131 -0.18 18 149
PI3K 0.032 0.11 0.2 79 -0.23 31 110
PIK3R1 -0.075 0.13 -10000 0 -0.31 131 131
KRAS 0.025 0.082 0.24 71 -10000 0 71
FOXO 0.025 0.051 0.18 30 -10000 0 30
AKT2 -0.004 0.023 0.24 5 -10000 0 5
PTEN -0.012 0.042 -10000 0 -0.31 11 11
Endothelins

Figure S20.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S20.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
AKT1 0.031 0.2 0.38 100 -0.31 12 112
PTK2B -0.004 0.014 -10000 0 -0.31 1 1
mol:Ca2+ 0.034 0.14 0.52 5 -0.53 1 6
EDN1 0.027 0.15 0.3 100 -0.26 6 106
EDN3 -0.003 0.027 0.24 7 -10000 0 7
EDN2 -0.001 0.036 0.24 12 -10000 0 12
HRAS/GDP 0.025 0.16 0.33 33 -0.4 14 47
ETA receptor/Endothelin-1/Gq/GTP/PLC beta 0.01 0.13 0.23 91 -0.33 14 105
ADCY4 0.052 0.16 0.25 177 -0.26 12 189
ADCY5 0.052 0.16 0.25 178 -0.26 12 190
ADCY6 0.052 0.16 0.25 177 -0.26 12 189
ADCY7 0.052 0.16 0.25 177 -0.26 12 189
ADCY1 0.052 0.16 0.25 177 -0.26 12 189
ADCY2 0.052 0.16 0.25 177 -0.26 12 189
ADCY3 0.052 0.16 0.25 177 -0.26 12 189
ADCY8 -0.03 0.16 0.26 75 -0.29 67 142
ADCY9 0.041 0.17 0.25 174 -0.27 27 201
arachidonic acid secretion -0.098 0.24 0.46 21 -0.54 77 98
ETB receptor/Endothelin-1/Gq/GTP 0.035 0.12 0.24 30 -0.27 17 47
GNAO1 -0.004 0.028 0.24 6 -0.31 1 7
HRAS -0.005 0.004 -10000 0 -10000 0 0
ETA receptor/Endothelin-1/G12/GTP 0.02 0.18 0.38 98 -0.28 12 110
ETA receptor/Endothelin-1/Gs/GTP 0.03 0.17 0.35 98 -0.27 12 110
mol:GTP 0.002 0.011 -10000 0 -10000 0 0
COL3A1 0.14 0.31 0.52 203 -0.51 5 208
EDNRB 0.051 0.083 0.16 178 -10000 0 178
response to oxidative stress 0 0 -10000 0 -10000 0 0
CYSLTR2 -0.012 0.26 0.39 97 -0.43 108 205
CYSLTR1 0.05 0.22 0.42 118 -0.37 5 123
SLC9A1 0.013 0.13 0.27 95 -0.22 5 100
mol:GDP 0.028 0.17 0.27 98 -0.36 22 120
SLC9A3 0.073 0.15 0.36 19 -0.54 1 20
RAF1 0.014 0.19 0.41 30 -0.39 53 83
JUN 0.034 0.16 0.55 13 -0.79 3 16
JAK2 0.032 0.2 0.38 98 -0.32 14 112
mol:IP3 0.017 0.14 0.25 92 -0.4 9 101
ETA receptor/Endothelin-1 0.017 0.22 0.46 96 -0.37 12 108
PLCB1 0.002 0.043 0.24 16 -0.31 1 17
PLCB2 -0.003 0.01 -10000 0 -10000 0 0
ETA receptor/Endothelin-3 0.013 0.094 0.19 95 -0.16 2 97
FOS -0.053 0.33 0.57 26 -0.87 65 91
Gai/GDP 0.03 0.056 -10000 0 -0.38 1 1
CRK -0.003 0.011 0.24 1 -10000 0 1
mol:Ca ++ 0.06 0.22 0.34 162 -0.4 16 178
BCAR1 -0.006 0.013 -10000 0 -0.31 1 1
PRKCB1 0.034 0.14 0.24 100 -0.37 11 111
GNAQ -0.009 0.046 -10000 0 -0.31 12 12
GNAZ -0.008 0.025 -10000 0 -0.31 4 4
GNAL -0.006 0 -10000 0 -10000 0 0
Gs family/GDP -0.04 0.092 -10000 0 -0.32 25 25
ETA receptor/Endothelin-1/Gq/GTP 0.01 0.15 0.26 88 -0.35 18 106
MAPK14 0.027 0.1 0.23 23 -0.28 10 33
TRPC6 0.033 0.15 0.55 4 -0.56 1 5
GNAI2 -0.006 0 -10000 0 -10000 0 0
GNAI3 0.036 0.093 0.24 96 -10000 0 96
GNAI1 -0.005 0.041 0.24 8 -0.31 5 13
ETB receptor/Endothelin-1/Gq/GTP/PLC beta 0.031 0.11 0.24 29 -0.29 11 40
ETB receptor/Endothelin-2 0.04 0.067 0.17 47 -10000 0 47
ETB receptor/Endothelin-3 0.038 0.062 0.16 35 -10000 0 35
ETB receptor/Endothelin-1 0.044 0.15 0.34 100 -0.23 5 105
MAPK3 -0.044 0.31 0.53 27 -0.76 67 94
MAPK1 -0.038 0.29 0.53 27 -0.74 65 92
Rac1/GDP 0.025 0.16 0.34 29 -0.4 13 42
cAMP biosynthetic process -0.008 0.16 0.24 53 -0.29 57 110
MAPK8 0.031 0.16 0.45 13 -0.49 5 18
SRC -0.005 0.003 -10000 0 -10000 0 0
ETB receptor/Endothelin-1/Gi/GTP 0.062 0.096 0.2 123 -10000 0 123
p130Cas/CRK/Src/PYK2 0.029 0.16 0.39 25 -0.48 8 33
mol:K + 0 0 -10000 0 -10000 0 0
G12/GDP 0.025 0.16 0.34 29 -0.4 13 42
COL1A2 0.15 0.32 0.58 179 -0.59 7 186
EntrezGene:2778 0 0 -10000 0 -10000 0 0
ETA receptor/Endothelin-2 0.015 0.098 0.2 97 -0.16 2 99
mol:DAG 0.016 0.14 0.25 92 -0.4 9 101
MAP2K2 -0.027 0.25 0.48 27 -0.56 67 94
MAP2K1 -0.004 0.23 0.5 27 -0.53 62 89
EDNRA 0.018 0.14 0.27 93 -0.22 8 101
positive regulation of muscle contraction 0.024 0.16 0.32 95 -0.27 12 107
Gq family/GDP -0.046 0.11 0.27 10 -0.4 20 30
HRAS/GTP 0.027 0.16 0.33 36 -0.36 23 59
PRKCH 0.032 0.14 0.24 99 -0.41 9 108
RAC1 -0.006 0.013 -10000 0 -0.31 1 1
PRKCA 0.033 0.14 0.24 99 -0.41 8 107
PRKCB 0.02 0.14 0.24 99 -0.36 12 111
PRKCE 0.019 0.14 0.24 99 -0.39 9 108
PRKCD 0.032 0.14 0.24 99 -0.38 11 110
PRKCG 0.032 0.14 0.24 99 -0.37 11 110
regulation of vascular smooth muscle contraction -0.074 0.38 0.57 26 -1 65 91
PRKCQ 0.018 0.14 0.3 31 -0.38 10 41
PLA2G4A -0.11 0.26 0.46 21 -0.6 77 98
GNA14 -0.001 0.02 0.24 2 -10000 0 2
GNA15 -0.004 0.02 0.24 1 -0.31 1 2
GNA12 -0.006 0 -10000 0 -10000 0 0
GNA11 -0.032 0.089 -10000 0 -0.31 53 53
Rac1/GTP 0.02 0.18 0.38 98 -0.28 12 110
MMP1 0.046 0.1 0.42 33 -10000 0 33
Coregulation of Androgen receptor activity

Figure S21.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S21.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
NRIP1 -0.12 0.15 -10000 0 -0.31 218 218
SVIL -0.013 0.05 0.24 1 -0.31 15 16
ZNF318 -0.005 0.01 0.24 1 -10000 0 1
JMJD2C -0.006 0.015 0.24 2 -10000 0 2
T-DHT/AR/Ubc9 -0.14 0.084 -10000 0 -0.2 328 328
CARM1 -0.005 0.01 0.24 1 -10000 0 1
PRDX1 -0.006 0 -10000 0 -10000 0 0
PELP1 -0.006 0 -10000 0 -10000 0 0
CTNNB1 -0.005 0.015 0.24 2 -10000 0 2
AKT1 -0.005 0.01 0.24 1 -10000 0 1
PTK2B -0.006 0.013 -10000 0 -0.31 1 1
MED1 -0.005 0.015 0.24 2 -10000 0 2
MAK -0.068 0.12 0.24 2 -0.31 119 121
response to oxidative stress 0 0 -10000 0 -10000 0 0
HIP1 -0.006 0 -10000 0 -10000 0 0
GSN -0.044 0.1 -10000 0 -0.31 71 71
NCOA2 -0.005 0.015 0.24 2 -10000 0 2
NCOA6 -0.005 0.01 0.24 1 -10000 0 1
DNA-PK 0.038 0.059 0.16 114 -10000 0 114
NCOA4 -0.006 0 -10000 0 -10000 0 0
PIAS3 -0.005 0.01 0.24 1 -10000 0 1
cell proliferation -0.17 0.25 0.23 2 -0.65 119 121
XRCC5 0.008 0.056 0.24 31 -10000 0 31
UBE3A -0.006 0 -10000 0 -10000 0 0
T-DHT/AR/SNURF -0.14 0.085 -10000 0 -0.2 328 328
FHL2 -0.083 0.061 0.41 2 -0.5 3 5
RANBP9 -0.005 0.018 0.24 3 -10000 0 3
JMJD1A -0.005 0.12 0.24 86 -10000 0 86
CDK6 -0.002 0.043 0.24 13 -0.31 3 16
TGFB1I1 -0.028 0.079 -10000 0 -0.31 42 42
T-DHT/AR/CyclinD1 -0.18 0.11 -10000 0 -0.24 386 386
XRCC6 -0.006 0 -10000 0 -10000 0 0
T-DHT/AR -0.17 0.098 -10000 0 -0.29 162 162
CTDSP1 -0.007 0.022 -10000 0 -0.31 3 3
CTDSP2 -0.007 0.018 -10000 0 -0.31 2 2
BRCA1 0.008 0.058 0.24 33 -10000 0 33
TCF4 -0.007 0.018 -10000 0 -0.31 2 2
CDKN2A 0.13 0.12 0.24 314 -10000 0 314
SRF -0.007 0.026 0.23 2 -0.31 3 5
NKX3-1 -0.092 0.12 -10000 0 -10000 0 0
KLK3 -0.018 0.057 -10000 0 -10000 0 0
TMF1 -0.005 0.018 0.24 3 -10000 0 3
HNRNPA1 -0.006 0 -10000 0 -10000 0 0
AOF2 -0.005 0.01 0.24 1 -10000 0 1
APPL1 -0.007 0.009 0.2 1 -10000 0 1
T-DHT/AR/Caspase 8 -0.14 0.084 -10000 0 -0.2 328 328
AR -0.21 0.14 -10000 0 -0.33 329 329
UBA3 0 0 -10000 0 -10000 0 0
PATZ1 -0.005 0.01 0.24 1 -10000 0 1
PAWR -0.006 0 -10000 0 -10000 0 0
PRKDC 0.036 0.093 0.24 97 -10000 0 97
PA2G4 -0.005 0.01 0.24 1 -10000 0 1
UBE2I -0.006 0 -10000 0 -10000 0 0
T-DHT/AR/Cyclin D3/CDK11 p58 -0.12 0.076 -10000 0 -0.18 328 328
RPS6KA3 -0.003 0.032 0.24 8 -0.31 1 9
T-DHT/AR/ARA70 -0.14 0.084 -10000 0 -0.2 328 328
LATS2 -0.006 0 -10000 0 -10000 0 0
T-DHT/AR/PRX1 -0.12 0.076 -10000 0 -0.18 328 328
Cyclin D3/CDK11 p58 -0.003 0 -10000 0 -10000 0 0
VAV3 0.022 0.079 0.24 65 -10000 0 65
KLK2 -0.082 0.045 -10000 0 -10000 0 0
CASP8 -0.006 0 -10000 0 -10000 0 0
T-DHT/AR/TIF2/CARM1 -0.13 0.077 0.15 1 -0.18 326 327
TMPRSS2 -0.34 0.38 -10000 0 -0.76 245 245
CCND1 -0.085 0.13 0.24 1 -0.31 150 151
PIAS1 -0.005 0.01 0.24 1 -10000 0 1
mol:T-DHT -0.024 0.028 -10000 0 -0.066 128 128
CDC2L1 0 0 -10000 0 -10000 0 0
PIAS4 -0.006 0 -10000 0 -10000 0 0
T-DHT/AR/CDK6 -0.14 0.087 0.15 1 -0.2 319 320
CMTM2 -0.006 0 -10000 0 -10000 0 0
SNURF -0.006 0.013 -10000 0 -0.31 1 1
ZMIZ1 -0.032 0.038 0.23 1 -0.31 4 5
CCND3 -0.006 0 -10000 0 -10000 0 0
TGIF1 -0.006 0 -10000 0 -10000 0 0
FKBP4 0.006 0.054 0.24 28 -10000 0 28
Signaling events mediated by PRL

Figure S22.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S22.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CCNE1 0.22 0.073 0.24 515 -10000 0 515
mol:Halofuginone -0.002 0.015 -10000 0 -0.18 4 4
ITGA1 0.034 0.091 0.24 92 -10000 0 92
CDKN1A -0.015 0.081 -10000 0 -0.43 20 20
PRL-3/alpha Tubulin -0.007 0.031 0.17 8 -0.21 7 15
mol:Ca2+ -0.014 0.058 0.28 7 -0.2 35 42
AGT -0.02 0.064 -10000 0 -0.31 27 27
CCNA2 0.056 0.094 0.26 2 -0.65 4 6
TUBA1B -0.006 0 -10000 0 -10000 0 0
EGR1 -0.083 0.1 0.2 3 -0.22 215 218
CDK2/Cyclin E1 0.16 0.11 0.27 204 -0.31 12 216
MAPK3 -0.012 0.047 0.2 8 -0.22 20 28
PRL-2 /Rab GGTase beta 0.074 0.088 0.17 260 -10000 0 260
MAPK1 -0.007 0.035 0.2 9 -0.21 8 17
PTP4A1 -0.067 0.092 -10000 0 -0.71 4 4
PTP4A3 -0.006 0.045 0.24 8 -0.31 7 15
PTP4A2 -0.006 0 -10000 0 -10000 0 0
ITGB1 -0.004 0.037 0.2 13 -0.21 6 19
SRC -0.006 0 -10000 0 -10000 0 0
RAC1 -0.007 0.063 -10000 0 -0.41 12 12
Rab GGTase beta/Rab GGTase alpha 0.074 0.088 0.17 260 -10000 0 260
PRL-1/ATF-5 -0.064 0.087 -10000 0 -0.68 4 4
RABGGTA -0.006 0 -10000 0 -10000 0 0
BCAR1 -0.005 0.038 0.28 7 -0.17 9 16
RHOC -0.006 0.06 -10000 0 -0.4 11 11
RHOA -0.007 0.063 -10000 0 -0.4 13 13
cell motility -0.035 0.07 -10000 0 -0.41 11 11
PRL-1/alpha Tubulin -0.065 0.086 -10000 0 -0.68 4 4
PRL-3/alpha1 Integrin 0.022 0.071 0.17 99 -0.21 6 105
ROCK1 -0.035 0.07 -10000 0 -0.41 11 11
RABGGTB 0.11 0.12 0.24 260 -10000 0 260
CDK2 0.094 0.12 0.24 229 -10000 0 229
mitosis -0.067 0.092 -10000 0 -0.71 4 4
ATF5 -0.005 0.019 0.24 2 -0.31 1 3
PDGFR-alpha signaling pathway

Figure S23.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S23.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PDGFRA -0.043 0.11 0.24 9 -0.32 73 82
PDGF/PDGFRA/CRKL -0.031 0.074 0.16 9 -0.21 73 82
positive regulation of JUN kinase activity -0.005 0.066 0.15 20 -0.16 70 90
CRKL -0.006 0 -10000 0 -10000 0 0
PDGF/PDGFRA/Caveolin-3 -0.031 0.074 0.16 9 -0.21 73 82
AP1 -0.084 0.27 0.53 26 -0.76 65 91
mol:IP3 -0.03 0.086 0.19 17 -0.22 71 88
PLCG1 -0.03 0.086 0.19 17 -0.22 71 88
PDGF/PDGFRA/alphaV Integrin -0.026 0.085 0.18 27 -0.21 75 102
RAPGEF1 -0.006 0 -10000 0 -10000 0 0
CRK -0.005 0.01 0.24 1 -10000 0 1
mol:Ca2+ -0.03 0.085 0.19 17 -0.22 71 88
CAV3 -0.006 0 -10000 0 -10000 0 0
CAV1 -0.053 0.11 0.24 2 -0.31 90 92
SHC/Grb2/SOS1 -0.005 0.067 0.15 20 -0.16 70 90
PDGF/PDGFRA/Shf -0.031 0.074 0.16 9 -0.21 73 82
FOS -0.084 0.27 0.53 25 -0.75 65 90
JUN -0.006 0.051 0.22 16 -0.24 2 18
oligodendrocyte development -0.026 0.085 0.18 27 -0.21 75 102
GRB2 -0.006 0 -10000 0 -10000 0 0
PIK3R1 -0.075 0.13 -10000 0 -0.31 131 131
mol:DAG -0.03 0.086 0.19 17 -0.22 71 88
PDGF/PDGFRA -0.043 0.11 0.24 9 -0.32 73 82
actin cytoskeleton reorganization -0.031 0.074 0.16 9 -0.21 73 82
SRF -0.005 0.019 -10000 0 -0.21 3 3
SHC1 -0.006 0 -10000 0 -10000 0 0
PI3K -0.032 0.12 0.16 95 -0.21 146 241
PDGF/PDGFRA/Crk/C3G -0.026 0.061 0.15 9 -0.18 72 81
JAK1 -0.031 0.076 0.19 9 -0.21 75 84
ELK1/SRF -0.035 0.062 -10000 0 -0.19 73 73
SHB -0.006 0 -10000 0 -10000 0 0
SHF -0.006 0 -10000 0 -10000 0 0
CSNK2A1 0 0.021 -10000 0 -10000 0 0
GO:0007205 -0.033 0.097 0.2 17 -0.26 71 88
SOS1 0.005 0.05 0.24 24 -10000 0 24
Ras protein signal transduction -0.005 0.066 0.15 20 -0.16 70 90
PDGF/PDGFRA/SHB -0.031 0.074 0.16 9 -0.21 73 82
PDGF/PDGFRA/Caveolin-1 -0.062 0.11 0.18 10 -0.25 139 149
ITGAV 0.001 0.05 0.24 19 -0.31 3 22
ELK1 -0.032 0.092 0.18 33 -0.23 71 104
PIK3CA 0.047 0.1 0.24 122 -10000 0 122
PDGF/PDGFRA/Crk -0.03 0.073 0.16 9 -0.21 72 81
JAK-STAT cascade -0.031 0.075 0.19 9 -0.21 75 84
cell proliferation -0.031 0.074 0.16 9 -0.21 73 82
Syndecan-1-mediated signaling events

Figure S24.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S24.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TGFB1 -0.054 0.11 -10000 0 -0.31 90 90
CCL5 -0.029 0.088 0.24 6 -0.31 48 54
SDCBP -0.006 0.023 0.24 2 -0.31 2 4
FGFR/FGF2/Syndecan-1 -0.04 0.15 0.23 35 -0.38 55 90
mol:PI-4-5-P2 0 0 -10000 0 -10000 0 0
RP11-540L11.1 0 0 -10000 0 -10000 0 0
Syndecan-1/Laminin-5 -0.046 0.14 0.2 35 -0.36 55 90
Syndecan-1/Syntenin -0.046 0.14 0.2 35 -0.36 55 90
MAPK3 -0.048 0.14 0.18 33 -0.33 60 93
HGF/MET 0.008 0.065 0.17 62 -0.21 12 74
TGFB1/TGF beta receptor Type II -0.054 0.11 -10000 0 -0.31 90 90
BSG -0.006 0 -10000 0 -10000 0 0
keratinocyte migration -0.045 0.14 0.2 35 -0.36 55 90
Syndecan-1/RANTES -0.053 0.16 0.2 37 -0.38 68 105
Syndecan-1/CD147 -0.048 0.14 0.18 29 -0.35 55 84
Syndecan-1/Syntenin/PIP2 -0.056 0.12 -10000 0 -0.35 55 55
LAMA5 -0.005 0.01 0.24 1 -10000 0 1
positive regulation of cell-cell adhesion -0.056 0.12 -10000 0 -0.34 55 55
MMP7 -0.1 0.16 0.24 21 -0.31 200 221
HGF -0.004 0.021 0.24 4 -10000 0 4
Syndecan-1/CASK -0.046 0.14 0.2 35 -0.36 55 90
Syndecan-1/HGF/MET -0.035 0.15 0.21 49 -0.34 58 107
regulation of cell adhesion -0.049 0.13 0.18 33 -0.32 60 93
HPSE 0.001 0.041 0.24 16 -10000 0 16
positive regulation of cell migration -0.04 0.15 0.23 35 -0.38 55 90
SDC1 -0.041 0.16 0.23 35 -0.38 55 90
Syndecan-1/Collagen -0.04 0.15 0.23 35 -0.38 55 90
PPIB -0.006 0 -10000 0 -10000 0 0
MET 0.014 0.089 0.24 59 -0.31 12 71
PRKACA -0.006 0 -10000 0 -10000 0 0
MMP9 0.034 0.091 0.24 92 -10000 0 92
MAPK1 -0.045 0.13 0.18 34 -0.34 55 89
homophilic cell adhesion -0.045 0.15 0.23 35 -0.37 55 90
MMP1 0.047 0.1 0.24 121 -10000 0 121
Reelin signaling pathway

Figure S25.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S25.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CDK5R1/CDK5 0.013 0.056 0.17 65 -10000 0 65
VLDLR -0.014 0.055 0.24 3 -0.31 17 20
CRKL -0.006 0 -10000 0 -10000 0 0
LRPAP1 -0.006 0.025 0.24 3 -0.31 2 5
FYN -0.047 0.1 0.24 1 -0.31 79 80
ITGA3 -0.031 0.088 0.24 3 -0.31 50 53
RELN/VLDLR/Fyn -0.046 0.1 0.16 22 -0.19 171 193
MAPK8IP1/MKK7/MAP3K11/JNK1 0.015 0.018 -10000 0 -0.15 1 1
AKT1 -0.049 0.11 0.2 3 -0.2 170 173
MAP2K7 -0.006 0 -10000 0 -10000 0 0
RAPGEF1 -0.006 0 -10000 0 -10000 0 0
DAB1 -0.006 0 -10000 0 -10000 0 0
RELN/LRP8/DAB1 -0.013 0.072 0.15 26 -0.16 96 122
LRPAP1/LRP8 -0.005 0.025 0.17 9 -0.21 2 11
RELN/LRP8/DAB1/Fyn -0.032 0.087 0.15 23 -0.16 159 182
DAB1/alpha3/beta1 Integrin -0.049 0.062 -10000 0 -0.15 149 149
long-term memory -0.044 0.084 0.15 22 -0.28 14 36
DAB1/LIS1 -0.032 0.064 -10000 0 -0.28 2 2
DAB1/CRLK/C3G -0.039 0.053 -10000 0 -0.15 110 110
PIK3CA 0.047 0.1 0.24 122 -10000 0 122
DAB1/NCK2 -0.013 0.072 0.24 1 -0.15 110 111
ARHGEF2 -0.005 0.015 0.24 2 -10000 0 2
mol:Src family inhibitors PP1 and PP2 0 0 -10000 0 -10000 0 0
GRIN2A -0.001 0.058 0.24 20 -0.31 8 28
CDK5R1 -0.006 0 -10000 0 -10000 0 0
RELN -0.048 0.13 0.24 22 -0.31 97 119
PIK3R1 -0.075 0.13 -10000 0 -0.31 131 131
RELN/LRP8/Fyn -0.041 0.099 0.16 22 -0.19 159 181
GRIN2A/RELN/LRP8/DAB1/Fyn -0.029 0.094 0.28 2 -0.16 159 161
MAPK8 -0.003 0.025 0.24 6 -10000 0 6
RELN/VLDLR/DAB1 -0.019 0.075 0.15 24 -0.16 112 136
ITGB1 -0.003 0.025 0.24 6 -10000 0 6
MAP1B -0.048 0.083 0.18 2 -0.18 140 142
RELN/LRP8 -0.016 0.081 0.16 28 -0.18 97 125
GRIN2B/RELN/LRP8/DAB1/Fyn -0.031 0.089 0.28 1 -0.16 159 160
PI3K -0.015 0.12 0.17 98 -0.21 107 205
mol:PP2 0 0 -10000 0 -10000 0 0
alpha3/beta1 Integrin -0.022 0.063 0.17 9 -0.21 50 59
RAP1A -0.034 0.059 0.21 1 -0.26 2 3
PAFAH1B1 -0.005 0.015 0.24 2 -10000 0 2
MAPK8IP1 -0.005 0.01 0.24 1 -10000 0 1
CRLK/C3G -0.007 0 -10000 0 -10000 0 0
GRIN2B -0.005 0.015 0.24 2 -10000 0 2
NCK2 -0.006 0 -10000 0 -10000 0 0
neuron differentiation -0.043 0.083 0.18 1 -0.34 13 14
neuron adhesion -0.045 0.066 0.2 1 -0.26 7 8
LRP8 -0.003 0.025 0.24 6 -10000 0 6
GSK3B -0.049 0.1 0.18 3 -0.19 170 173
RELN/VLDLR/DAB1/Fyn -0.038 0.09 0.14 22 -0.16 171 193
MAP3K11 -0.006 0.013 -10000 0 -0.31 1 1
RELN/VLDLR/DAB1/P13K -0.047 0.12 0.21 3 -0.21 170 173
CDK5 0.022 0.079 0.24 65 -10000 0 65
MAPT 0.006 0.014 -10000 0 -10000 0 0
neuron migration -0.054 0.12 0.18 14 -0.25 95 109
RELN/LRP8/DAB1/Fyn/MAPK8IP1/MKK7/MAP3K11/JNK1 -0.044 0.084 0.18 1 -0.34 13 14
RELN/VLDLR -0.016 0.08 0.16 29 -0.16 110 139
Integrins in angiogenesis

Figure S26.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S26.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
VEGFR2 homodimer/VEGFA homodimer 0.009 0.052 0.17 50 -10000 0 50
alphaV beta3 Integrin -0.014 0.08 0.16 24 -0.19 83 107
PTK2 -0.018 0.12 0.26 9 -0.29 66 75
IGF1R -0.07 0.12 -10000 0 -0.31 121 121
PI4KB -0.004 0.021 0.24 4 -10000 0 4
MFGE8 -0.015 0.068 0.24 8 -0.31 24 32
SRC -0.006 0 -10000 0 -10000 0 0
CDKN1B -0.016 0.045 0.16 4 -0.4 3 7
VEGFA 0.016 0.069 0.24 49 -10000 0 49
ILK -0.016 0.032 -10000 0 -10000 0 0
ROCK1 -0.005 0.01 0.24 1 -10000 0 1
AKT1 -0.017 0.029 -10000 0 -10000 0 0
PTK2B -0.013 0.074 0.26 7 -0.16 73 80
alphaV/beta3 Integrin/JAM-A -0.025 0.07 0.16 27 -0.29 6 33
CBL -0.006 0 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
alphaV beta3 Integrin/ANGPTL3 -0.011 0.075 0.16 25 -0.18 77 102
IGF-1R heterotetramer/IGF1/IRS1/Shp2 -0.13 0.12 -10000 0 -0.2 381 381
VEGF/Rho/ROCK/alphaV/beta3 Integrin -0.012 0.074 0.2 7 -0.35 4 11
alphaV/beta3 Integrin/Syndecan-1 -0.01 0.076 0.16 28 -0.18 77 105
PI4KA -0.004 0.018 0.24 3 -10000 0 3
IGF-1R heterotetramer/IGF1/IRS1 -0.12 0.11 -10000 0 -0.21 279 279
PI4 Kinase -0.005 0.02 0.17 7 -10000 0 7
PIK3CA 0.047 0.1 0.24 122 -10000 0 122
alphaV/beta3 Integrin/Osteopontin 0.034 0.11 0.16 195 -0.18 74 269
RPS6KB1 -0.098 0.12 0.22 6 -0.28 107 113
TLN1 -0.006 0.013 -10000 0 -0.31 1 1
MAPK3 -0.093 0.15 0.2 3 -0.42 80 83
GPR124 -0.014 0.048 -10000 0 -0.31 15 15
MAPK1 -0.09 0.14 0.2 3 -0.42 80 83
PXN -0.01 0.033 -10000 0 -0.31 7 7
PIK3R1 -0.075 0.13 -10000 0 -0.31 131 131
alphaV/beta3 Integrin/Tumstatin -0.011 0.075 0.16 25 -0.18 78 103
cell adhesion -0.03 0.086 0.18 26 -0.2 90 116
ANGPTL3 -0.005 0.01 0.24 1 -10000 0 1
VEGFR2 homodimer/VEGFA homodimer/Src 0.021 0.041 0.16 49 -10000 0 49
IGF-1R heterotetramer -0.07 0.12 -10000 0 -0.31 121 121
Rac1/GDP -0.004 0.009 -10000 0 -0.21 1 1
TGFBR2 -0.01 0.036 -10000 0 -0.31 8 8
ITGB3 -0.041 0.11 0.24 12 -0.31 77 89
IGF1 -0.016 0.06 0.24 3 -0.31 21 24
RAC1 -0.006 0.013 -10000 0 -0.31 1 1
regulation of cell-matrix adhesion -0.016 0.079 0.16 24 -0.18 90 114
apoptosis 0.001 0.05 0.24 19 -0.31 3 22
CD47 0.007 0.057 0.24 30 -0.31 1 31
alphaV/beta3 Integrin/CD47 -0.004 0.081 0.16 49 -0.18 76 125
VCL -0.005 0.015 0.24 2 -10000 0 2
alphaV/beta3 Integrin/Del1 0.008 0.092 0.16 95 -0.18 75 170
CSF1 -0.018 0.06 0.24 1 -0.31 23 24
PIK3C2A -0.016 0.036 0.16 1 -0.35 1 2
PI4 Kinase/Pyk2 -0.033 0.047 -10000 0 -0.26 6 6
VEGFR2 homodimer/VEGFA homodimer/alphaV beta3 Integrin 0.006 0.083 0.16 67 -0.16 72 139
FAK1/Vinculin -0.014 0.098 0.24 9 -0.24 66 75
alphaV beta3/Integrin/ppsTEM5 -0.016 0.08 0.16 24 -0.18 90 114
RHOA -0.007 0.018 -10000 0 -0.31 2 2
VTN -0.006 0 -10000 0 -10000 0 0
BCAR1 -0.006 0.013 -10000 0 -0.31 1 1
FGF2 -0.011 0.04 -10000 0 -0.31 10 10
F11R -0.01 0.028 0.2 1 -0.21 10 11
alphaV/beta3 Integrin/Lactadherin -0.016 0.086 0.16 30 -0.19 92 122
alphaV/beta3 Integrin/TGFBR2 -0.013 0.079 0.16 24 -0.19 80 104
alphaV/beta3 Integrin/c-FMS/Cbl/Cas 0.008 0.046 0.15 19 -0.17 25 44
HSP90AA1 -0.006 0.013 -10000 0 -0.31 1 1
alphaV/beta3 Integrin/Talin -0.008 0.072 0.16 28 -0.16 78 106
mol:GDP 0 0 -10000 0 -10000 0 0
FN1 0.075 0.13 0.24 200 -0.31 12 212
alphaV/beta3 Integrin/Pyk2 -0.01 0.078 0.18 29 -0.16 73 102
SDC1 -0.004 0.021 0.24 4 -10000 0 4
VAV3 0.005 0.064 0.15 77 -0.16 22 99
PTPN11 -0.006 0 -10000 0 -10000 0 0
IRS1 -0.2 0.15 -10000 0 -0.31 357 357
FAK1/Paxillin -0.016 0.099 0.24 9 -0.24 67 76
cell migration -0.015 0.094 0.23 9 -0.22 66 75
ITGAV 0.001 0.05 0.24 19 -0.31 3 22
PI3K -0.03 0.1 0.14 102 -0.25 29 131
SPP1 0.079 0.12 0.24 202 -0.31 6 208
KDR -0.005 0.015 0.24 2 -10000 0 2
mol:PI-4-5-P2 0 0 -10000 0 -10000 0 0
alphaV/beta3 Integrin/Caspase 8 0.001 0.05 0.24 19 -0.31 3 22
COL4A3 -0.006 0 -10000 0 -10000 0 0
angiogenesis -0.087 0.16 0.21 1 -0.44 83 84
Rac1/GTP 0.002 0.059 0.14 62 -0.27 1 63
EDIL3 0.029 0.087 0.24 81 -10000 0 81
cell proliferation -0.013 0.079 0.16 24 -0.19 80 104
IL1-mediated signaling events

Figure S27.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S27.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
UBC13/UEV1A -0.004 0.009 -10000 0 -0.21 1 1
PRKCZ -0.006 0 -10000 0 -10000 0 0
MAP3K7IP2 -0.004 0.018 0.24 3 -10000 0 3
ERC1 -0.005 0.024 0.24 4 -0.31 1 5
IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4 -0.004 0.058 0.23 14 -0.21 1 15
IRAK/TOLLIP -0.007 0.013 0.14 3 -0.16 1 4
IKBKB -0.005 0.015 0.24 2 -10000 0 2
IKBKG -0.006 0 -10000 0 -10000 0 0
IL1 alpha/IL1R2 -0.001 0.045 0.19 23 -0.21 6 29
IL1A -0.001 0.036 0.24 12 -10000 0 12
IL1B -0.004 0.094 0.21 56 -0.21 52 108
IRAK/TRAF6/p62/Atypical PKCs 0.053 0.071 0.13 257 -10000 0 257
IL1R2 -0.003 0.049 0.24 13 -0.31 6 19
IL1R1 -0.12 0.15 -10000 0 -0.31 225 225
IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP -0.061 0.12 0.18 12 -0.23 150 162
TOLLIP -0.006 0 -10000 0 -10000 0 0
TICAM2 -0.006 0.016 0.24 1 -0.31 1 2
MAP3K3 -0.006 0 -10000 0 -10000 0 0
TAK1/TAB1/TAB2 0.011 0.018 0.16 9 -10000 0 9
IKK complex/ELKS 0.002 0.034 -10000 0 -0.28 1 1
JUN 0.008 0.051 0.22 8 -10000 0 8
MAP3K7 -0.003 0.025 0.24 6 -10000 0 6
IL1 beta fragment/IL1R1/IL1RAP/PI3K -0.041 0.15 0.28 32 -0.26 83 115
IL1 alpha/IL1R1/IL1RAP/MYD88 -0.022 0.1 -10000 0 -0.16 164 164
PIK3R1 -0.075 0.13 -10000 0 -0.31 131 131
IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4 -0.01 0.1 0.28 9 -0.15 148 157
IL1 beta fragment/IL1R1/IL1RAP -0.033 0.12 0.16 104 -0.18 181 285
NFKB1 -0.01 0.033 -10000 0 -0.31 7 7
MAPK8 0.008 0.052 0.23 7 -10000 0 7
IRAK1 -0.005 0.014 0.17 3 -0.17 1 4
IL1RN/IL1R1 -0.083 0.11 0.17 14 -0.21 224 238
IRAK4 0.015 0.069 0.24 48 -10000 0 48
PRKCI 0.1 0.12 0.24 255 -10000 0 255
TRAF6 -0.005 0.015 0.24 2 -10000 0 2
PI3K -0.015 0.12 0.17 98 -0.21 107 205
IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/TOLLIP -0.032 0.12 0.2 23 -0.29 24 47
CHUK 0.002 0.043 0.24 18 -10000 0 18
IL1 beta fragment/IL1R1/IL1RAP/MYD88s -0.033 0.12 0.16 104 -0.18 181 285
IL1 beta/IL1R2 -0.015 0.072 0.19 29 -0.18 58 87
IRAK/TRAF6/TAK1/TAB1/TAB2 -0.009 0.022 0.13 11 -10000 0 11
NF kappa B1 p50/RelA -0.077 0.094 -10000 0 -0.25 87 87
IRAK3 0.004 0.048 0.24 22 -10000 0 22
IL1 beta fragment/IL1R1/IL1RAP/TICAM2/IRAK4 -0.024 0.12 0.27 20 -0.28 23 43
IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4/TOLLIP -0.037 0.1 0.22 9 -10000 0 9
IL1 alpha/IL1R1/IL1RAP -0.025 0.11 0.16 82 -0.18 164 246
RELA -0.006 0.013 -10000 0 -0.31 1 1
MAP3K7IP1 -0.006 0 -10000 0 -10000 0 0
SQSTM1 -0.006 0 -10000 0 -10000 0 0
MYD88 -0.006 0 -10000 0 -10000 0 0
IRAK/TRAF6/MEKK3 -0.008 0.015 0.14 5 -0.15 1 6
IL1RAP 0.052 0.11 0.24 135 -0.31 1 136
UBE2N -0.006 0.013 -10000 0 -0.31 1 1
IRAK/TRAF6 -0.054 0.068 -10000 0 -0.24 29 29
CASP1 -0.025 0.1 0.24 19 -0.31 52 71
IL1RN/IL1R2 0 0.044 0.17 28 -0.21 6 34
IL1 beta fragment/IL1R1/IL1RAP/MYD88 -0.033 0.12 0.16 76 -0.27 28 104
TMEM189-UBE2V1 0 0 -10000 0 -10000 0 0
IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP -0.081 0.14 -10000 0 -0.28 147 147
PIK3CA 0.047 0.1 0.24 122 -10000 0 122
IL1RN 0.001 0.04 0.24 15 -10000 0 15
TRAF6/TAK1/TAB1/TAB2 0.012 0.017 -10000 0 -0.14 1 1
MAP2K6 0.012 0.057 0.14 82 -10000 0 82
Ephrin B reverse signaling

Figure S28.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S28.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
EFNB2 -0.011 0.073 0.24 16 -0.31 23 39
EPHB2 0.002 0.033 0.24 10 -10000 0 10
EFNB1 -0.005 0.014 -10000 0 -0.21 2 2
mol:GTP 0 0 -10000 0 -10000 0 0
Rac1/GDP 0 0.036 0.18 6 -10000 0 6
Ephrin B2/EPHB1-2 0.012 0.051 0.16 36 -0.15 23 59
neuron projection morphogenesis -0.006 0.017 -10000 0 -0.14 4 4
Ephrin B1/EPHB1-2/Tiam1 0.003 0.038 0.16 22 -0.15 3 25
DNM1 -0.003 0.014 -10000 0 -0.31 1 1
cell-cell signaling 0.001 0.003 -10000 0 -10000 0 0
MAP2K4 -0.11 0.21 0.24 1 -0.5 123 124
YES1 -0.14 0.3 0.24 2 -0.72 123 125
Ephrin B1/EPHB1-2/NCK2 0.002 0.036 0.16 20 -0.15 2 22
PI3K -0.1 0.24 0.25 9 -0.52 123 132
mol:GDP 0.002 0.037 0.16 22 -0.15 3 25
ITGA2B -0.006 0 -10000 0 -10000 0 0
endothelial cell proliferation -0.004 0.044 0.15 16 -0.17 23 39
FYN -0.16 0.31 -10000 0 -0.74 123 123
MAP3K7 -0.11 0.22 0.27 1 -0.53 123 124
FGR -0.14 0.3 -10000 0 -0.71 123 123
TIAM1 -0.005 0.019 0.24 2 -0.31 1 3
PIK3R1 -0.075 0.13 -10000 0 -0.31 131 131
RGS3 -0.006 0 -10000 0 -10000 0 0
cell adhesion -0.12 0.23 0.24 11 -0.5 130 141
LYN -0.15 0.31 -10000 0 -0.72 123 123
Ephrin B1/EPHB1-2/Src Family Kinases -0.14 0.28 -10000 0 -0.66 123 123
Ephrin B1/EPHB1-2 -0.12 0.24 -10000 0 -0.57 123 123
SRC -0.14 0.3 -10000 0 -0.71 123 123
ITGB3 -0.041 0.11 0.24 12 -0.31 77 89
EPHB1 0.003 0.035 0.24 12 -10000 0 12
EPHB4 -0.006 0 -10000 0 -10000 0 0
RAC1 -0.006 0.013 -10000 0 -0.31 1 1
Ephrin B2/EPHB4 -0.004 0.044 0.16 16 -0.17 23 39
alphaIIb/beta3 Integrin -0.031 0.076 0.17 12 -0.21 77 89
BLK -0.14 0.3 -10000 0 -0.71 123 123
HCK -0.14 0.3 -10000 0 -0.71 123 123
regulation of stress fiber formation -0.002 0.035 0.15 2 -0.16 20 22
MAPK8 -0.1 0.2 0.22 1 -0.48 123 124
Ephrin B1/EPHB1-2/RGS3 0.002 0.036 0.16 20 -10000 0 20
endothelial cell migration -0.095 0.19 0.22 1 -0.44 123 124
NCK2 -0.006 0 -10000 0 -10000 0 0
PTPN13 -0.074 0.19 0.23 32 -0.42 123 155
regulation of focal adhesion formation -0.002 0.035 0.15 2 -0.16 20 22
chemotaxis -0.002 0.035 -10000 0 -0.16 20 20
PIK3CA 0.047 0.1 0.24 122 -10000 0 122
Rac1/GTP -0.001 0.032 0.13 22 -0.14 1 23
angiogenesis -0.12 0.24 -10000 0 -0.57 123 123
LCK -0.14 0.3 -10000 0 -0.71 123 123
LPA receptor mediated events

Figure S29.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S29.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
GNB1/GNG2 -0.016 0.06 0.15 1 -0.17 72 73
NF kappa B1 p50/RelA/I kappa B alpha -0.035 0.083 0.2 2 -0.26 31 33
AP1 -0.023 0.085 0.15 47 -0.16 110 157
mol:PIP3 -0.059 0.082 -10000 0 -0.16 190 190
AKT1 -0.03 0.088 0.25 3 -0.24 25 28
PTK2B -0.019 0.073 0.16 32 -0.17 72 104
RHOA -0.005 0.052 -10000 0 -0.37 2 2
PIK3CB 0.024 0.077 0.24 62 -10000 0 62
mol:Ca2+ -0.033 0.066 0.11 2 -0.16 84 86
MAGI3 0.001 0.038 0.24 14 -10000 0 14
RELA -0.005 0.013 -10000 0 -0.31 1 1
apoptosis -0.01 0.081 0.19 40 -0.18 70 110
HRAS/GDP -0.003 0 -10000 0 -10000 0 0
positive regulation of microtubule depolymerization -0.021 0.065 0.14 30 -0.16 68 98
NF kappa B1 p50/RelA -0.034 0.095 0.16 53 -0.19 80 133
endothelial cell migration -0.03 0.17 0.42 32 -0.41 71 103
ADCY4 -0.004 0.094 0.2 34 -0.21 61 95
ADCY5 -0.004 0.094 0.2 34 -0.21 61 95
ADCY6 -0.005 0.094 0.2 34 -0.21 61 95
ADCY7 -0.005 0.094 0.2 34 -0.21 61 95
ADCY1 -0.005 0.094 0.2 34 -0.21 61 95
ADCY2 -0.005 0.094 0.2 34 -0.21 61 95
ADCY3 -0.004 0.094 0.2 34 -0.21 61 95
ADCY8 -0.071 0.11 0.19 12 -0.27 70 82
ADCY9 -0.015 0.11 0.2 34 -0.24 64 98
GSK3B -0.021 0.07 0.15 32 -0.17 72 104
arachidonic acid secretion -0.006 0.088 0.19 34 -0.2 61 95
GNG2 -0.002 0.011 0.24 1 -10000 0 1
TRIP6 -0.007 0.026 -10000 0 -0.3 3 3
GNAO1 -0.013 0.088 0.22 37 -0.19 71 108
HRAS -0.006 0 -10000 0 -10000 0 0
NFKBIA -0.037 0.085 0.17 2 -0.25 41 43
GAB1 -0.007 0.018 -10000 0 -0.31 2 2
mol:GTP 0 0 -10000 0 -10000 0 0
lamellipodium assembly 0.006 0.036 -10000 0 -0.84 1 1
JUN 0 0.042 0.24 14 -0.31 2 16
LPA/LPA2/NHERF2 -0.033 0.064 -10000 0 -0.18 79 79
TIAM1 0.004 0.043 -10000 0 -0.98 1 1
PIK3R1 -0.075 0.13 -10000 0 -0.31 131 131
mol:IP3 -0.033 0.067 0.11 2 -0.16 84 86
PLCB3 -0.027 0.063 -10000 0 -0.16 79 79
FOS -0.028 0.11 0.24 26 -0.31 65 91
positive regulation of mitosis -0.006 0.088 0.19 34 -0.2 61 95
LPA/LPA1-2-3 -0.019 0.057 0.05 1 -0.17 71 72
mol:Ca ++ 0 0 -10000 0 -10000 0 0
JNK cascade 0 0.001 -10000 0 -10000 0 0
BCAR1 -0.006 0.013 -10000 0 -0.31 1 1
stress fiber formation -0.014 0.081 0.18 32 -0.22 29 61
GNAZ -0.015 0.088 0.23 32 -0.19 74 106
EGFR/PI3K-beta/Gab1 -0.06 0.085 -10000 0 -0.17 190 190
positive regulation of dendritic cell cytokine production -0.019 0.057 0.049 1 -0.17 71 72
LPA/LPA2/MAGI-3 -0.006 0.031 0.15 10 -10000 0 10
ARHGEF1 -0.016 0.072 0.19 32 -0.16 72 104
GNAI2 -0.014 0.086 0.23 32 -0.19 71 103
GNAI3 0.015 0.11 0.19 117 -0.19 63 180
GNAI1 -0.013 0.09 0.22 38 -0.2 72 110
LPA/LPA3 -0.011 0.029 -10000 0 -0.087 71 71
LPA/LPA2 -0.011 0.029 -10000 0 -0.087 71 71
LPA/LPA1 -0.029 0.075 -10000 0 -0.23 71 71
HB-EGF/EGFR 0.007 0.077 0.15 87 -0.18 40 127
HBEGF 0.029 0.08 0.2 93 -10000 0 93
mol:DAG -0.033 0.067 0.11 2 -0.16 84 86
cAMP biosynthetic process -0.016 0.092 0.18 34 -0.22 62 96
NFKB1 -0.009 0.034 -10000 0 -0.31 7 7
SRC -0.006 0 -10000 0 -10000 0 0
GNB1 -0.003 0.014 -10000 0 -0.31 1 1
LYN -0.038 0.085 0.15 4 -0.24 45 49
GNAQ -0.007 0.044 0.1 32 -0.19 12 44
LPAR2 0 0.001 -10000 0 -10000 0 0
LPAR3 0 0.001 -10000 0 -10000 0 0
LPAR1 -0.011 0.057 0.13 32 -0.14 71 103
IL8 0.018 0.2 0.47 61 -0.35 42 103
PTK2 -0.002 0.08 0.18 55 -0.16 68 123
Rac1/GDP -0.004 0.009 -10000 0 -0.21 1 1
CASP3 -0.01 0.081 0.19 40 -0.18 70 110
EGFR -0.028 0.084 0.25 1 -0.31 46 47
PLCG1 -0.013 0.051 0.098 30 -0.18 16 46
PLD2 -0.01 0.072 0.19 32 -0.16 71 103
G12/G13 -0.023 0.058 -10000 0 -0.17 72 72
PI3K-beta -0.05 0.072 -10000 0 -0.26 26 26
cell migration -0.005 0.044 0.18 2 -0.27 1 3
SLC9A3R2 -0.047 0.1 -10000 0 -0.31 79 79
PXN -0.015 0.082 0.18 32 -0.22 29 61
HRAS/GTP -0.006 0.088 0.19 33 -0.2 61 94
RAC1 -0.006 0.013 -10000 0 -0.31 1 1
MMP9 0.035 0.091 0.24 92 -10000 0 92
PRKCE -0.003 0.011 0.24 1 -10000 0 1
PRKCD -0.033 0.065 0.12 2 -0.18 46 48
Gi(beta/gamma) -0.003 0.09 0.2 34 -0.2 61 95
mol:LPA -0.011 0.057 0.13 32 -0.14 71 103
TRIP6/p130 Cas/FAK1/Paxillin -0.013 0.083 0.18 32 -0.2 20 52
MAPKKK cascade -0.006 0.088 0.19 34 -0.2 61 95
contractile ring contraction involved in cytokinesis -0.005 0.052 -10000 0 -0.37 2 2
mol:GDP 0 0 -10000 0 -10000 0 0
GNA14 -0.003 0.035 0.1 33 -10000 0 33
GNA15 -0.004 0.036 0.1 33 -0.25 1 34
GNA12 -0.006 0 -10000 0 -10000 0 0
GNA13 -0.006 0.013 -10000 0 -0.31 1 1
MAPT -0.022 0.067 0.15 30 -0.16 68 98
GNA11 -0.02 0.064 0.1 30 -0.19 51 81
Rac1/GTP 0.007 0.039 -10000 0 -0.89 1 1
MMP2 -0.03 0.18 0.43 32 -0.41 71 103
Ras signaling in the CD4+ TCR pathway

Figure S30.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S30.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
ERK1-2/ELK1 -0.005 0.13 0.4 26 -0.29 52 78
MAP3K8 -0.006 0.007 -10000 0 -10000 0 0
FOS 0.006 0.095 0.31 26 -0.35 6 32
PRKCA -0.004 0.04 0.24 7 -0.31 4 11
PTPN7 -0.004 0.02 -10000 0 -10000 0 0
HRAS -0.006 0.004 -10000 0 -10000 0 0
PRKCB 0 0.011 0.045 26 -0.015 65 91
NRAS 0.12 0.12 0.24 300 -10000 0 300
RAS family/GTP 0.094 0.085 0.17 281 -10000 0 281
MAPK3 0.002 0.089 0.22 12 -0.45 14 26
MAP2K1 0.022 0.057 0.21 15 -0.29 4 19
ELK1 -0.007 0.014 -10000 0 -10000 0 0
BRAF 0.003 0.04 0.24 4 -0.28 4 8
mol:GTP 0 0.003 0.008 26 -0.006 65 91
MAPK1 0.012 0.055 0.22 12 -0.37 1 13
RAF1 0.003 0.039 0.21 3 -0.28 4 7
KRAS 0.025 0.082 0.24 71 -10000 0 71
Thromboxane A2 receptor signaling

Figure S31.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S31.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TGM2 -0.2 0.15 0.25 1 -0.31 367 368
GNB1/GNG2 -0.064 0.065 -10000 0 -0.2 78 78
AKT1 -0.038 0.18 0.36 80 -10000 0 80
EGF -0.003 0.027 0.24 7 -10000 0 7
mol:TXA2 0 0.001 -10000 0 -10000 0 0
FGR -0.017 0.04 0.28 1 -10000 0 1
mol:Ca2+ -0.083 0.25 0.43 78 -0.36 63 141
LYN -0.02 0.045 0.28 1 -0.24 1 2
RhoA/GTP -0.062 0.053 -10000 0 -0.13 106 106
mol:PGI2 0 0.001 -10000 0 -10000 0 0
SYK -0.08 0.25 0.44 80 -0.37 76 156
GNG2 -0.004 0.011 0.24 1 -10000 0 1
ARRB2 -0.006 0 -10000 0 -10000 0 0
TP alpha/Gq family/GDP/G beta5/gamma2 -0.033 0.09 -10000 0 -0.29 60 60
G beta5/gamma2 -0.078 0.086 0.14 1 -0.26 77 78
PRKCH -0.094 0.26 0.45 80 -0.4 76 156
DNM1 -0.006 0.013 -10000 0 -0.31 1 1
TXA2/TP beta/beta Arrestin3 0.015 0.022 -10000 0 -10000 0 0
mol:GTP 0 0.006 0.1 1 -10000 0 1
PTGDR -0.004 0.004 -10000 0 -10000 0 0
G12 family/GTP -0.14 0.12 -10000 0 -0.3 108 108
ADRBK1 -0.004 0.004 -10000 0 -10000 0 0
ADRBK2 -0.031 0.086 -10000 0 -0.31 50 50
RhoA/GTP/ROCK1 -0.002 0.015 0.15 1 -0.18 2 3
mol:GDP 0.064 0.19 0.45 33 -0.31 76 109
mol:NADP -0.005 0.004 -10000 0 -10000 0 0
RAB11A -0.006 0 -10000 0 -10000 0 0
PRKG1 -0.005 0.011 0.24 1 -10000 0 1
mol:IP3 -0.11 0.28 0.46 78 -0.44 76 154
cell morphogenesis -0.002 0.015 0.15 1 -0.18 2 3
PLCB2 -0.17 0.33 0.49 73 -0.62 76 149
mol:cGMP -0.001 0.001 -10000 0 -10000 0 0
BLK -0.017 0.041 0.21 2 -10000 0 2
mol:PDG2 0 0.001 -10000 0 -10000 0 0
HCK -0.017 0.041 0.22 2 -10000 0 2
RHOA -0.007 0.018 -10000 0 -0.31 2 2
PTGIR -0.006 0.018 -10000 0 -0.31 2 2
PRKCB1 -0.1 0.28 0.46 80 -0.43 76 156
GNAQ -0.012 0.043 -10000 0 -0.31 12 12
mol:L-citrulline -0.005 0.004 -10000 0 -10000 0 0
TXA2/TXA2-R family -0.14 0.33 0.5 80 -0.58 76 156
LCK -0.017 0.04 0.28 1 -10000 0 1
TXA2/TP beta/beta Arrestin3/RAB11/GDP -0.004 0.018 -10000 0 -10000 0 0
TXA2-R family/G12 family/GDP/G beta/gamma 0.001 0.02 -10000 0 -0.43 1 1
TXA2/TP beta/beta Arrestin2/RAB11/GDP -0.004 0.018 -10000 0 -0.16 1 1
MAPK14 -0.045 0.2 0.38 80 -0.25 57 137
TGM2/GTP -0.16 0.32 0.49 73 -0.49 107 180
MAPK11 -0.046 0.2 0.38 80 -0.25 59 139
ARHGEF1 -0.046 0.16 0.3 73 -0.2 12 85
GNAI2 -0.006 0 -10000 0 -10000 0 0
JNK cascade -0.091 0.28 0.48 80 -0.42 76 156
RAB11/GDP -0.001 0.011 -10000 0 -0.14 1 1
ICAM1 -0.045 0.24 0.45 80 -0.33 16 96
cAMP biosynthetic process -0.13 0.27 0.43 73 -0.42 66 139
Gq family/GTP/EBP50 -0.065 0.11 -10000 0 -0.23 158 158
actin cytoskeleton reorganization -0.002 0.015 0.15 1 -0.18 2 3
SRC -0.017 0.04 0.28 1 -10000 0 1
GNB5 -0.008 0.031 -10000 0 -0.31 6 6
GNB1 -0.006 0.013 -10000 0 -0.31 1 1
EGF/EGFR -0.031 0.057 0.26 1 -0.19 19 20
VCAM1 -0.055 0.25 0.46 80 -0.38 76 156
TP beta/Gq family/GDP/G beta5/gamma2 -0.033 0.09 -10000 0 -0.29 60 60
platelet activation -0.077 0.24 0.43 80 -0.33 63 143
PGI2/IP -0.002 0.013 -10000 0 -0.21 2 2
PRKACA -0.003 0.012 -10000 0 -0.18 2 2
Gq family/GDP/G beta5/gamma2 -0.03 0.083 -10000 0 -0.26 60 60
TXA2/TP beta/beta Arrestin2 0.011 0.028 -10000 0 -0.37 1 1
positive regulation of NF-kappaB transcription factor activity 0 0 -10000 0 -10000 0 0
TBXA2R -0.005 0.013 -10000 0 -0.16 2 2
mol:DAG -0.12 0.29 0.48 73 -0.49 76 149
EGFR -0.03 0.083 0.24 1 -0.31 46 47
TXA2/TP alpha -0.18 0.33 0.49 73 -0.54 98 171
Gq family/GTP -0.019 0.055 -10000 0 -0.17 61 61
YES1 -0.011 0.049 0.17 9 -10000 0 9
GNAI2/GTP -0.019 0.039 -10000 0 -0.14 32 32
PGD2/DP -0.002 0.005 -10000 0 -10000 0 0
SLC9A3R1 -0.075 0.13 -10000 0 -0.31 130 130
FYN -0.03 0.059 0.28 1 -0.23 13 14
mol:NO -0.005 0.004 -10000 0 -10000 0 0
GNA15 -0.006 0.016 0.24 1 -0.31 1 2
PGK/cGMP -0.002 0.01 0.15 1 -10000 0 1
RhoA/GDP -0.002 0.021 -10000 0 -0.25 3 3
TP alpha/TGM2/GDP/G beta/gamma -0.09 0.061 -10000 0 -0.28 1 1
NOS3 -0.005 0.004 -10000 0 -10000 0 0
RAC1 -0.006 0.013 -10000 0 -0.31 1 1
PRKCA -0.093 0.26 0.45 80 -0.4 76 156
PRKCB -0.09 0.26 0.45 80 -0.4 76 156
PRKCE -0.089 0.26 0.46 80 -0.4 76 156
PRKCD -0.094 0.27 0.46 80 -0.42 76 156
PRKCG -0.11 0.28 0.46 80 -0.44 76 156
muscle contraction -0.13 0.32 0.49 80 -0.54 76 156
PRKCZ -0.08 0.26 0.45 80 -0.37 76 156
ARR3 -0.006 0 -10000 0 -10000 0 0
TXA2/TP beta -0.014 0.046 0.27 1 -0.16 1 2
PRKCQ -0.092 0.26 0.45 80 -0.4 77 157
MAPKKK cascade -0.13 0.31 0.47 80 -0.53 76 156
SELE -0.054 0.23 0.43 80 -0.31 62 142
TP beta/GNAI2/GDP/G beta/gamma -0.008 0.015 -10000 0 -10000 0 0
ROCK1 -0.005 0.01 0.24 1 -10000 0 1
GNA14 -0.005 0.015 0.24 2 -10000 0 2
chemotaxis -0.14 0.35 0.53 80 -0.62 76 156
GNA12 -0.006 0 -10000 0 -10000 0 0
GNA13 -0.006 0.013 -10000 0 -0.31 1 1
GNA11 -0.034 0.088 -10000 0 -0.31 53 53
Rac1/GTP -0.003 0.011 -10000 0 -0.21 1 1
IL4-mediated signaling events

Figure S32.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S32.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BCL2L1 -0.07 0.54 0.91 6 -1.2 48 54
STAT6 (cleaved dimer) -0.25 0.41 0.53 1 -1.1 85 86
IGHG1 0.025 0.27 0.57 42 -0.94 3 45
IGHG3 -0.079 0.5 0.76 6 -1.2 51 57
AKT1 -0.081 0.34 0.54 4 -0.86 40 44
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHP1 -0.029 0.32 0.48 12 -1 26 38
IL4/IL4R/JAK1/IL2R gamma/JAK3/IRS1 -0.15 0.37 0.56 2 -0.89 58 60
THY1 -0.015 0.59 1 40 -1.3 41 81
MYB -0.025 0.075 0.24 1 -0.31 37 38
HMGA1 -0.004 0.028 0.24 6 -0.31 1 7
IL4/IL4R/JAK1/IL2R gamma/JAK3 -0.019 0.38 0.64 41 -0.94 24 65
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHIP -0.038 0.37 0.58 11 -1.1 26 37
SP1 0.067 0.11 0.22 183 -10000 0 183
INPP5D 0 0 -10000 0 -10000 0 0
SOCS5 -0.007 0.034 0.24 2 -10000 0 2
STAT6 (dimer)/ETS1 -0.12 0.52 0.7 2 -1.2 62 64
SOCS1 -0.058 0.37 0.62 2 -0.79 49 51
SOCS3 -0.023 0.33 0.61 1 -0.88 18 19
FCER2 -0.013 0.42 0.83 11 -0.88 22 33
PARP14 0.049 0.11 0.24 129 -0.31 3 132
CCL17 -0.07 0.54 0.91 6 -1.2 47 53
GRB2 -0.006 0 -10000 0 -10000 0 0
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP -0.012 0.29 0.5 25 -0.74 23 48
T cell proliferation -0.13 0.57 0.75 1 -1.3 72 73
IL4R/JAK1 -0.14 0.58 0.72 6 -1.4 71 77
EGR2 -0.068 0.54 0.97 8 -1.2 47 55
JAK2 0.02 0.079 0.2 25 -0.35 2 27
JAK3 -0.001 0.012 -10000 0 -10000 0 0
PIK3R1 -0.075 0.13 -10000 0 -0.31 131 131
JAK1 0.011 0.037 -10000 0 -0.31 2 2
COL1A2 0.096 0.35 0.6 103 -1.2 6 109
CCL26 -0.07 0.54 0.91 6 -1.2 48 54
IL4R -0.11 0.67 0.95 22 -1.5 68 90
PTPN6 -0.005 0.027 -10000 0 -10000 0 0
IL13RA2 -0.059 0.54 0.95 11 -1.2 46 57
IL13RA1 0.017 0.086 0.19 40 -0.34 7 47
IRF4 0.023 0.17 0.56 1 -10000 0 1
ARG1 0.026 0.23 0.59 6 -0.82 3 9
CBL -0.026 0.35 0.57 25 -0.8 35 60
GTF3A 0.12 0.12 0.23 293 -10000 0 293
PIK3CA 0.047 0.1 0.24 122 -10000 0 122
IL13RA1/JAK2 0.039 0.12 0.28 49 -0.25 9 58
IRF4/BCL6 0.009 0.14 -10000 0 -10000 0 0
CD40LG -0.005 0.014 0.24 2 -10000 0 2
MAPK14 -0.026 0.36 0.62 12 -0.89 24 36
mitosis -0.074 0.33 0.52 5 -0.81 38 43
STAT6 -0.06 0.65 1.1 42 -1.4 50 92
SPI1 -0.007 0.02 0.19 1 -0.31 2 3
RPS6KB1 -0.071 0.32 0.53 5 -0.79 36 41
STAT6 (dimer) -0.062 0.64 1.1 42 -1.4 50 92
STAT6 (dimer)/PARP14 -0.074 0.54 0.86 6 -1.3 51 57
mast cell activation -0.005 0.024 -10000 0 -10000 0 0
IL4/IL4R/JAK1/IL2R gamma/JAK3/DOK2 -0.036 0.36 0.58 11 -1.1 26 37
FRAP1 -0.081 0.34 0.54 4 -0.86 40 44
LTA -0.07 0.54 0.91 6 -1.2 48 54
FES -0.006 0 -10000 0 -10000 0 0
T-helper 1 cell differentiation 0.054 0.63 1.4 50 -1.1 42 92
CCL11 -0.068 0.52 0.86 20 -1.2 48 68
IL4/IL4R/JAK1/IL2R gamma/JAK3/FES -0.036 0.36 0.57 11 -1.1 26 37
IL2RG -0.004 0.089 0.24 30 -0.3 30 60
IL10 -0.07 0.54 0.91 6 -1.2 48 54
IRS1 -0.2 0.15 -10000 0 -0.31 357 357
IRS2 -0.006 0 -10000 0 -10000 0 0
IL4 0.053 0.24 0.62 42 -10000 0 42
IL5 -0.07 0.54 0.91 6 -1.2 48 54
IL4/IL4R/JAK1/IL13RA1/JAK2 -0.027 0.51 0.88 42 -1 47 89
COL1A1 0.22 0.4 0.78 118 -1.5 1 119
positive regulation of NF-kappaB transcription factor activity 0 0 -10000 0 -10000 0 0
IL4/IL4R/JAK1 -0.16 0.59 0.72 1 -1.4 68 69
IL2R gamma/JAK3 -0.001 0.063 0.18 30 -0.2 30 60
TFF3 -0.65 0.6 0.89 4 -1.3 169 173
ALOX15 -0.072 0.54 0.91 6 -1.2 48 54
MYBL1 0.027 0.084 0.24 76 -10000 0 76
T-helper 2 cell differentiation -0.059 0.49 0.77 11 -1.1 55 66
SHC1 -0.006 0 -10000 0 -10000 0 0
CEBPB -0.007 0.029 0.22 2 -0.31 4 6
IL4/IL4R/JAK1/IL2R gamma/JAK3/FES/IRS2 -0.037 0.37 0.57 11 -1.1 26 37
mol:PI-3-4-5-P3 -0.081 0.34 0.54 4 -0.86 40 44
PI3K -0.09 0.36 0.55 3 -0.94 40 43
DOK2 -0.005 0.01 0.24 1 -10000 0 1
ETS1 -0.008 0.05 0.24 10 -10000 0 10
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP/GRB2 -0.011 0.28 0.47 40 -0.72 23 63
ITGB3 -0.14 0.66 1 8 -1.4 83 91
PIGR -0.099 0.59 1 11 -1.3 62 73
IGHE -0.048 0.098 -10000 0 -0.25 68 68
MAPKKK cascade -0.01 0.28 0.46 40 -0.7 23 63
BCL6 -0.013 0.047 -10000 0 -0.31 14 14
OPRM1 -0.07 0.54 0.9 7 -1.2 48 55
RETNLB -0.07 0.54 0.91 6 -1.2 48 54
SELP -0.096 0.56 0.92 7 -1.3 57 64
AICDA -0.079 0.5 0.81 1 -1.2 48 49
Nectin adhesion pathway

Figure S33.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S33.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PDGFRB -0.01 0.033 -10000 0 -0.31 7 7
alphaV beta3 Integrin -0.026 0.088 0.19 28 -0.22 78 106
PTK2 -0.05 0.11 0.21 7 -0.41 31 38
positive regulation of JNK cascade -0.028 0.069 -10000 0 -0.29 34 34
CDC42/GDP -0.022 0.1 -10000 0 -0.39 34 34
Rac1/GDP -0.022 0.1 -10000 0 -0.39 34 34
RAP1B -0.004 0.023 0.24 5 -10000 0 5
RAP1A -0.005 0.01 0.24 1 -10000 0 1
CTNNB1 -0.005 0.015 0.24 2 -10000 0 2
CDC42/GTP -0.032 0.085 -10000 0 -0.36 34 34
nectin-3/I-afadin 0.003 0.077 0.17 69 -0.21 31 100
RAPGEF1 -0.029 0.11 -10000 0 -0.43 34 34
mol:GTP 0 0 -10000 0 -10000 0 0
CRK -0.03 0.13 -10000 0 -0.48 34 34
PDGFB-D/PDGFRB -0.01 0.033 -10000 0 -0.31 7 7
TLN1 -0.11 0.13 -10000 0 -0.26 235 235
Rap1/GTP -0.035 0.074 -10000 0 -0.32 34 34
IQGAP1 -0.006 0.021 0.24 1 -0.31 2 3
Rap1/GTP/I-afadin 0.001 0.04 0.15 6 -0.16 29 35
nectin-3(dimer)/I-afadin/I-afadin/nectin-3(dimer)/I-afadin/I-afadin 0.003 0.077 0.17 69 -0.21 31 100
PVR -0.006 0 -10000 0 -10000 0 0
Necl-5(dimer) -0.006 0 -10000 0 -10000 0 0
mol:GDP -0.027 0.12 -10000 0 -0.48 34 34
MLLT4 -0.021 0.066 -10000 0 -0.31 29 29
PIK3CA 0.047 0.1 0.24 122 -10000 0 122
PI3K 0.007 0.11 0.28 12 -0.17 119 131
nectin-1(dimer)/I-afadin/I-afadin/nectin-1(dimer)/I-afadin/I-afadin -0.017 0.046 0.17 1 -0.21 29 30
positive regulation of lamellipodium assembly -0.03 0.075 -10000 0 -0.31 36 36
PVRL1 -0.005 0.01 0.24 1 -10000 0 1
PVRL3 0.023 0.088 0.24 72 -0.31 5 77
PVRL2 -0.006 0.016 0.24 1 -0.31 1 2
PIK3R1 -0.075 0.13 -10000 0 -0.31 131 131
CDH1 -0.013 0.045 -10000 0 -0.31 13 13
CLDN1 -0.094 0.14 0.24 1 -0.31 167 168
JAM-A/CLDN1 -0.031 0.1 0.15 51 -0.17 165 216
SRC -0.032 0.14 -10000 0 -0.53 34 34
ITGB3 -0.041 0.11 0.24 12 -0.31 77 89
nectin-1(dimer)/I-afadin/I-afadin -0.017 0.046 0.17 1 -0.21 29 30
FARP2 -0.025 0.12 -10000 0 -0.46 34 34
RAC1 -0.006 0.013 -10000 0 -0.31 1 1
CTNNA1 -0.007 0.018 -10000 0 -0.31 2 2
nectin-3(dimer)/I-afadin/I-afadin/Necl-5(dimer) 0.017 0.067 0.16 69 -0.18 31 100
nectin-1/I-afadin -0.017 0.046 0.17 1 -0.21 29 30
nectin-2/I-afadin -0.017 0.046 0.17 1 -0.21 30 31
RAC1/GTP/IQGAP1/filamentous actin 0.005 0.014 0.15 1 -0.18 3 4
nectin-1(dimer)/I-afadin/I-afadin/nectin-3(dimer/I-afadin/I-afadin 0.017 0.067 0.16 70 -0.18 31 101
CDC42/GTP/IQGAP1/filamentous actin 0.005 0.012 0.15 1 -0.18 2 3
F11R -0.005 0.01 0.24 1 -10000 0 1
positive regulation of filopodium formation -0.028 0.069 -10000 0 -0.29 34 34
alphaV/beta3 Integrin/Talin -0.12 0.14 0.17 13 -0.26 236 249
nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin -0.017 0.046 0.17 1 -0.21 30 31
nectin-2(dimer)/I-afadin/I-afadin -0.017 0.046 0.17 1 -0.21 30 31
PIP5K1C -0.11 0.14 -10000 0 -0.27 235 235
VAV2 -0.027 0.13 -10000 0 -0.48 36 36
RAP1/GDP -0.029 0.092 0.19 1 -0.37 34 35
ITGAV 0.001 0.05 0.24 19 -0.31 3 22
nectin-3(dimer)/I-afadin/I-afadin/nectin-2(dimer)/I-afadin/I-afadin 0.016 0.068 0.16 70 -0.18 32 102
nectin-3(dimer)/I-afadin/I-afadin 0.003 0.077 0.17 69 -0.21 31 100
Rac1/GTP -0.033 0.092 -10000 0 -0.37 36 36
PTPRM -0.12 0.16 -10000 0 -0.29 244 244
E-cadherin/beta catenin/alpha catenin 0.001 0.046 -10000 0 -0.16 39 39
adherens junction assembly 0 0 -10000 0 -10000 0 0
CDC42 -0.006 0 -10000 0 -10000 0 0
FAS signaling pathway (CD95)

Figure S34.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S34.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
SPTAN1 0.023 0.064 0.16 92 -0.16 5 97
RFC1 0.027 0.065 0.16 91 -10000 0 91
PRKDC 0.051 0.089 0.2 94 -10000 0 94
RIPK1 -0.006 0.005 -10000 0 -10000 0 0
CASP7 0.002 0.024 -10000 0 -10000 0 0
FASLG/FAS/FADD/FAF1 0.018 0.081 0.26 2 -0.19 16 18
MAP2K4 -0.002 0.063 0.29 10 -0.27 9 19
mol:ceramide -0.007 0.052 0.24 10 -10000 0 10
GSN 0.005 0.077 0.16 75 -0.16 53 128
FASLG/FAS/FADD/FAF1/Caspase 8 0.014 0.073 0.25 2 -0.31 1 3
FAS -0.016 0.058 0.24 1 -0.31 21 22
BID -0.007 0.008 0.17 1 -10000 0 1
MAP3K1 0.006 0.048 0.21 10 -10000 0 10
MAP3K7 -0.003 0.026 0.24 6 -10000 0 6
RB1 0.029 0.069 0.16 106 -0.16 3 109
CFLAR -0.006 0.005 -10000 0 -10000 0 0
HGF/MET -0.015 0.1 0.16 74 -0.19 124 198
ARHGDIB 0.014 0.074 0.16 88 -0.16 33 121
FADD -0.005 0.007 -10000 0 -10000 0 0
actin filament polymerization -0.005 0.077 0.16 53 -0.16 75 128
NFKB1 -0.004 0.088 0.28 10 -0.67 7 17
MAPK8 -0.004 0.081 0.35 10 -0.44 9 19
DFFA 0.024 0.062 0.16 93 -10000 0 93
DNA fragmentation during apoptosis 0.024 0.062 0.16 92 -10000 0 92
FAS/FADD/MET 0.014 0.068 0.16 58 -0.19 29 87
CFLAR/RIP1 -0.007 0.008 -10000 0 -10000 0 0
FAIM3 -0.006 0.002 -10000 0 -10000 0 0
FAF1 -0.003 0.027 0.24 6 -10000 0 6
PARP1 0.037 0.075 0.17 132 -10000 0 132
DFFB 0.024 0.062 0.16 91 -10000 0 91
CHUK -0.002 0.082 0.24 10 -0.62 7 17
FASLG -0.005 0.009 -10000 0 -10000 0 0
FAS/FADD -0.013 0.041 0.17 1 -0.21 21 22
HGF -0.004 0.021 0.24 4 -10000 0 4
LMNA 0.055 0.087 0.27 39 -10000 0 39
CASP6 0.065 0.098 0.18 209 -0.16 1 210
CASP10 -0.004 0.022 0.24 4 -10000 0 4
CASP3 0.032 0.074 0.19 93 -0.17 1 94
PTPN13 -0.057 0.14 0.24 32 -0.31 123 155
CASP8 -0.006 0.003 -10000 0 -10000 0 0
IL6 -0.013 0.16 0.52 10 -0.99 11 21
MET 0.014 0.089 0.24 59 -0.31 12 71
ICAD/CAD 0.02 0.055 0.2 5 -10000 0 5
FASLG/FAS/FADD/FAF1/Caspase 10 -0.007 0.052 0.24 10 -10000 0 10
activation of caspase activity by cytochrome c -0.007 0.008 0.17 1 -10000 0 1
PAK2 0.025 0.063 0.16 96 -0.16 1 97
BCL2 -0.055 0.11 0.24 1 -0.31 93 94
TRAIL signaling pathway

Figure S35.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S35.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TNFSF10 0 0.12 0.24 63 -0.31 40 103
positive regulation of NF-kappaB transcription factor activity -0.001 0.08 0.17 64 -0.21 40 104
MAP2K4 -0.01 0.068 -10000 0 -0.25 9 9
IKBKB -0.005 0.015 0.24 2 -10000 0 2
TNFRSF10B -0.005 0.01 0.24 1 -10000 0 1
TNFRSF10A -0.005 0.015 0.24 2 -10000 0 2
SMPD1 -0.001 0.049 -10000 0 -10000 0 0
IKBKG -0.006 0 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
TNFRSF10D -0.005 0.01 0.24 1 -10000 0 1
TRAIL/TRAILR2 -0.001 0.08 0.17 64 -0.21 40 104
TRAIL/TRAILR3 -0.08 0.13 0.17 47 -0.23 226 273
TRAIL/TRAILR1 -0.001 0.081 0.17 65 -0.21 40 105
TRAIL/TRAILR4 -0.001 0.08 0.17 64 -0.21 40 104
TRAIL/TRAILR1/DAP3/GTP 0.014 0.066 0.15 72 -0.16 40 112
IKK complex -0.007 0.036 0.19 3 -10000 0 3
RIPK1 -0.006 0 -10000 0 -10000 0 0
response to oxidative stress 0 0 -10000 0 -10000 0 0
DAP3/GTP -0.001 0.019 0.17 7 -10000 0 7
MAPK3 -0.004 0.091 0.2 61 -0.21 52 113
MAP3K1 -0.007 0.07 -10000 0 -0.21 47 47
TRAILR4 (trimer) -0.005 0.01 0.24 1 -10000 0 1
TRADD -0.01 0.036 -10000 0 -0.31 8 8
TRAILR1 (trimer) -0.005 0.015 0.24 2 -10000 0 2
TRAIL/TRAILR1/FADD/TRADD/RIP/TRAF2 -0.006 0.066 -10000 0 -0.19 47 47
CFLAR -0.006 0 -10000 0 -10000 0 0
MAPK1 0.001 0.088 0.2 64 -0.21 41 105
TRAIL/TRAILR1/FADD/TRADD/RIP 0.014 0.066 -10000 0 -0.16 47 47
mol:ceramide -0.001 0.049 -10000 0 -10000 0 0
FADD -0.006 0 -10000 0 -10000 0 0
MAPK8 -0.011 0.065 -10000 0 -0.22 9 9
TRAF2 -0.006 0 -10000 0 -10000 0 0
TRAILR3 (trimer) -0.12 0.15 0.24 1 -0.31 224 225
CHUK 0.002 0.043 0.24 18 -10000 0 18
TRAIL/TRAILR1/FADD 0.013 0.07 0.16 65 -0.18 40 105
DAP3 -0.003 0.027 0.24 7 -10000 0 7
CASP10 -0.004 0.071 -10000 0 -0.2 40 40
JNK cascade -0.001 0.08 0.17 64 -0.21 40 104
TRAIL (trimer) 0 0.12 0.24 63 -0.31 40 103
TNFRSF10C -0.12 0.15 0.24 1 -0.31 224 225
TRAIL/TRAILR1/DAP3/GTP/FADD 0.015 0.063 0.14 72 -0.15 40 112
TRAIL/TRAILR2/FADD 0.012 0.07 0.16 64 -0.18 40 104
cell death -0.001 0.049 -10000 0 -10000 0 0
TRAIL/TRAILR2/FADD/TRADD/RIP/TRAF2 -0.007 0.065 -10000 0 -0.19 47 47
TRAILR2 (trimer) -0.005 0.01 0.24 1 -10000 0 1
CASP8 -0.001 0.031 -10000 0 -10000 0 0
negative regulation of caspase activity 0 0 -10000 0 -10000 0 0
TRAIL/TRAILR2/FADD/TRADD/RIP 0.014 0.065 -10000 0 -0.16 47 47
Plasma membrane estrogen receptor signaling

Figure S36.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S36.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
GNB1/GNG2 -0.011 0.054 -10000 0 -0.15 75 75
ER alpha/Gai/GDP/Gbeta gamma -0.02 0.11 -10000 0 -0.29 61 61
AKT1 -0.096 0.24 -10000 0 -0.67 75 75
PIK3CA 0.047 0.1 0.24 122 -10000 0 122
E2/ER alpha (dimer)/PELP1/Src/PI3K -0.091 0.25 -10000 0 -0.68 75 75
mol:Ca2+ -0.032 0.072 -10000 0 -0.34 15 15
IGF1R -0.07 0.12 -10000 0 -0.31 121 121
E2/ER alpha (dimer)/Striatin -0.017 0.062 0.15 2 -0.18 75 77
SHC1 -0.006 0 -10000 0 -10000 0 0
apoptosis 0.091 0.23 0.65 75 -10000 0 75
RhoA/GTP -0.012 0.028 -10000 0 -0.14 24 24
E2/ER alpha (dimer)/PELP1/Src/p130 Cas -0.039 0.1 -10000 0 -0.3 74 74
regulation of stress fiber formation -0.038 0.075 0.23 2 -0.2 39 41
E2/ERA-ERB (dimer) -0.018 0.061 -10000 0 -0.18 75 75
KRAS 0.025 0.082 0.24 71 -10000 0 71
G13/GTP -0.016 0.055 -10000 0 -0.16 76 76
pseudopodium formation 0.038 0.075 0.2 39 -0.23 2 41
E2/ER alpha (dimer)/PELP1 -0.018 0.061 -10000 0 -0.18 75 75
GRB2 -0.006 0 -10000 0 -10000 0 0
GNG2 -0.005 0.01 0.24 1 -10000 0 1
GNAO1 -0.004 0.028 0.24 6 -0.31 1 7
HRAS -0.006 0 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
mol:NO -0.046 0.14 -10000 0 -0.39 74 74
E2/ER beta (dimer) -0.003 0 -10000 0 -10000 0 0
mol:GDP -0.028 0.071 -10000 0 -0.22 68 68
mol:NADP -0.046 0.14 -10000 0 -0.39 74 74
PIK3R1 -0.075 0.13 -10000 0 -0.31 131 131
mol:IP3 -0.033 0.074 -10000 0 -0.35 15 15
IGF-1R heterotetramer -0.07 0.12 -10000 0 -0.31 121 121
PLCB1 -0.032 0.076 -10000 0 -0.35 16 16
PLCB2 -0.035 0.074 -10000 0 -0.35 16 16
IGF1 -0.016 0.06 0.24 3 -0.31 21 24
mol:L-citrulline -0.046 0.14 -10000 0 -0.39 74 74
RHOA -0.007 0.018 -10000 0 -0.31 2 2
Gai/GDP 0.019 0.055 -10000 0 -0.65 1 1
JNK cascade -0.003 0 -10000 0 -10000 0 0
BCAR1 -0.006 0.013 -10000 0 -0.31 1 1
ESR2 -0.006 0 -10000 0 -10000 0 0
GNAQ -0.012 0.043 -10000 0 -0.31 12 12
ESR1 -0.046 0.1 -10000 0 -0.31 75 75
Gq family/GDP/Gbeta gamma -0.033 0.1 -10000 0 -0.33 55 55
E2/ER alpha (dimer)/PELP1/Src/p52 SHC/GRB2/SOS1 -0.016 0.075 -10000 0 -10000 0 0
E2/ER alpha (dimer)/PELP1/Src/p52 SHC -0.039 0.1 -10000 0 -0.3 74 74
GNAZ -0.008 0.025 -10000 0 -0.31 4 4
E2/ER alpha (dimer) -0.031 0.069 -10000 0 -0.21 75 75
STRN -0.005 0.015 0.24 2 -10000 0 2
GNAL -0.006 0 -10000 0 -10000 0 0
PELP1 -0.006 0 -10000 0 -10000 0 0
MAPK11 -0.005 0 -10000 0 -10000 0 0
GNAI2 -0.006 0 -10000 0 -10000 0 0
GNAI3 0.036 0.093 0.24 96 -10000 0 96
GNAI1 -0.005 0.041 0.24 8 -0.31 5 13
HBEGF -0.015 0.1 -10000 0 -0.28 46 46
cAMP biosynthetic process -0.024 0.045 -10000 0 -0.14 75 75
SRC -0.021 0.1 -10000 0 -0.28 61 61
PI3K -0.015 0.12 0.17 98 -0.21 107 205
GNB1 -0.006 0.013 -10000 0 -0.31 1 1
G13/GDP/Gbeta gamma -0.028 0.062 -10000 0 -0.26 23 23
SOS1 0.005 0.05 0.24 24 -10000 0 24
IGF-1R heterotetramer/IGF1 -0.061 0.099 -10000 0 -0.28 75 75
Gs family/GTP -0.024 0.046 -10000 0 -0.14 75 75
EntrezGene:2778 0 0 -10000 0 -10000 0 0
RAS family/GTP 0.1 0.087 0.17 327 -10000 0 327
vasodilation -0.044 0.14 -10000 0 -0.38 74 74
mol:DAG -0.033 0.074 -10000 0 -0.35 15 15
Gs family/GDP/Gbeta gamma -0.028 0.063 -10000 0 -0.19 68 68
MSN 0.039 0.078 0.2 39 -0.24 2 41
Gq family/GTP -0.034 0.077 -10000 0 -0.37 16 16
mol:PI-3-4-5-P3 -0.088 0.24 -10000 0 -0.66 75 75
NRAS 0.12 0.12 0.24 300 -10000 0 300
mol:E2 0 0 -10000 0 -10000 0 0
cell adhesion 0.044 0.14 0.38 74 -10000 0 74
GRB2/SOS1 0.001 0.036 0.17 24 -10000 0 24
RhoA/GDP -0.029 0.069 -10000 0 -0.21 68 68
NOS3 -0.048 0.15 -10000 0 -0.41 74 74
GNA11 -0.034 0.088 -10000 0 -0.31 53 53
MAPKKK cascade -0.051 0.17 0.2 1 -0.48 75 76
E2/ER alpha (dimer)/PELP1/Src -0.03 0.11 -10000 0 -0.3 74 74
ruffle organization 0.038 0.075 0.2 39 -0.23 2 41
ROCK2 0.044 0.079 0.22 39 -10000 0 39
GNA14 -0.005 0.015 0.24 2 -10000 0 2
GNA15 -0.006 0.016 0.24 1 -0.31 1 2
GNA13 -0.006 0.013 -10000 0 -0.31 1 1
MMP9 -0.003 0.1 0.2 14 -0.27 48 62
MMP2 -0.031 0.11 0.19 2 -0.28 58 60
amb2 Integrin signaling

Figure S37.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S37.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
alphaM/beta2 Integrin/proMMP-2 -0.023 0.073 0.16 33 -0.18 74 107
alphaM/beta2 Integrin/GPIbA -0.01 0.021 0.16 4 -0.18 4 8
alphaM/beta2 Integrin/proMMP-9 0.014 0.062 0.16 85 -0.18 4 89
PLAUR 0 0.037 0.24 13 -10000 0 13
HMGB1 -0.006 0.01 -10000 0 -10000 0 0
alphaM/beta2 Integrin/Talin -0.01 0.022 0.16 4 -0.18 5 9
AGER -0.006 0.01 -10000 0 -10000 0 0
RAP1A -0.005 0.01 0.24 1 -10000 0 1
SELPLG -0.011 0.038 -10000 0 -0.31 9 9
mol:LDL 0 0 -10000 0 -10000 0 0
alphaM/beta2 Integrin/RAGE/HMGB1 -0.015 0.028 0.15 4 -0.18 9 13
mol:GTP 0 0 -10000 0 -10000 0 0
MMP9 0.034 0.091 0.24 92 -10000 0 92
CYR61 -0.008 0.066 0.24 15 -0.31 17 32
TLN1 -0.006 0.013 -10000 0 -0.31 1 1
Rap1/GTP -0.062 0.072 0.12 2 -0.27 20 22
RHOA -0.007 0.018 -10000 0 -0.31 2 2
P-selectin oligomer -0.018 0.062 0.24 1 -0.31 24 25
MYH2 -0.058 0.14 0.19 53 -0.34 22 75
MST1R -0.003 0.027 0.24 7 -10000 0 7
leukocyte activation during inflammatory response -0.01 0.018 0.13 5 -0.15 4 9
APOB -0.005 0.01 0.24 1 -10000 0 1
mol:GDP 0 0 -10000 0 -10000 0 0
complement component iC3b receptor activity 0 0 -10000 0 -10000 0 0
MMP2 -0.03 0.12 0.24 32 -0.31 71 103
JAM3 -0.005 0.015 0.24 2 -10000 0 2
GP1BA -0.006 0 -10000 0 -10000 0 0
alphaM/beta2 Integrin/CTGF -0.049 0.076 0.16 4 -0.18 131 135
alphaM/beta2 Integrin -0.039 0.12 0.18 53 -0.31 21 74
JAM3 homodimer -0.005 0.015 0.24 2 -10000 0 2
ICAM2 -0.008 0.028 -10000 0 -0.31 5 5
ICAM1 0.024 0.089 0.24 75 -0.31 5 80
phagocytosis triggered by activation of immune response cell surface activating receptor -0.038 0.12 0.18 53 -0.3 21 74
cell adhesion -0.01 0.021 0.15 4 -0.18 4 8
NFKB1 -0.014 0.068 0.36 11 -0.31 9 20
THY1 0.072 0.12 0.24 179 -0.31 1 180
RhoA/GDP -0.004 0.012 -10000 0 -0.21 2 2
Lipoprotein(a) 0.006 0.006 0.15 1 -10000 0 1
alphaM/beta2 Integrin/LRP/tPA -0.025 0.08 -10000 0 -0.17 123 123
IL6 -0.016 0.1 0.48 11 -0.57 9 20
ITGB2 -0.008 0.029 0.24 1 -0.31 4 5
elevation of cytosolic calcium ion concentration 0.037 0.078 0.15 172 -0.16 4 176
alphaM/beta2 Integrin/JAM2/JAM3 -0.044 0.084 -10000 0 -0.16 183 183
JAM2 -0.1 0.14 0.24 1 -0.31 182 183
alphaM/beta2 Integrin/ICAM1 0.03 0.056 0.25 8 -10000 0 8
alphaM/beta2 Integrin/uPA/Plg 0.047 0.075 0.29 3 -0.16 14 17
RhoA/GTP -0.059 0.15 0.2 53 -0.36 22 75
positive regulation of phagocytosis -0.051 0.063 0.34 1 -0.24 17 18
Ron/MSP -0.004 0.021 0.17 8 -10000 0 8
alphaM/beta2 Integrin/uPAR/uPA 0.052 0.072 0.29 6 -0.16 4 10
alphaM/beta2 Integrin/uPAR -0.008 0.026 0.16 9 -0.18 4 13
PLAU 0.072 0.12 0.24 179 -10000 0 179
PLAT -0.065 0.13 0.24 7 -0.31 117 124
actin filament polymerization -0.055 0.14 0.19 53 -0.33 22 75
MST1 -0.005 0.01 0.24 1 -10000 0 1
alphaM/beta2 Integrin/lipoprotein(a) 0.01 0.022 -10000 0 -0.15 4 4
TNF -0.014 0.066 0.36 11 -10000 0 11
RAP1B -0.004 0.023 0.24 5 -10000 0 5
alphaM/beta2 Integrin/uPA 0.038 0.078 0.16 168 -0.18 4 172
fibrinolysis 0.032 0.08 0.15 167 -0.16 14 181
HCK -0.005 0.01 0.24 1 -10000 0 1
dendritic cell antigen processing and presentation -0.038 0.12 0.18 53 -0.3 21 74
VTN -0.006 0 -10000 0 -10000 0 0
alphaM/beta2 Integrin/CYR61 -0.011 0.043 0.16 16 -0.18 21 37
LPA -0.006 0 -10000 0 -10000 0 0
LRP1 -0.01 0.036 -10000 0 -0.31 8 8
cell migration -0.004 0.08 0.25 4 -0.16 65 69
FN1 0.075 0.13 0.24 200 -0.31 12 212
alphaM/beta2 Integrin/Thy1 0.039 0.078 0.16 170 -0.18 3 173
MPO -0.006 0 -10000 0 -10000 0 0
KNG1 -0.005 0.01 0.24 1 -10000 0 1
RAP1/GDP 0.007 0.015 0.15 6 -10000 0 6
ROCK1 -0.057 0.14 0.19 53 -0.34 22 75
ELA2 -0.006 0 -10000 0 -10000 0 0
PLG -0.013 0.047 -10000 0 -0.31 14 14
CTGF -0.075 0.13 -10000 0 -0.31 131 131
alphaM/beta2 Integrin/Hck -0.01 0.02 0.16 3 -0.18 4 7
ITGAM -0.005 0.021 0.24 3 -10000 0 3
alphaM/beta2 Integrin/P-Selectin/PSGL1 0.001 0.051 0.29 1 -0.18 34 35
HP -0.14 0.19 0.24 54 -0.31 300 354
leukocyte adhesion -0.02 0.1 0.24 2 -0.3 1 3
SELP -0.018 0.062 0.24 1 -0.31 24 25
IL23-mediated signaling events

Figure S38.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S38.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CCL2 0.13 0.45 1 53 -1.2 17 70
IL23A 0.13 0.37 0.98 40 -10000 0 40
NF kappa B1 p50/RelA/I kappa B alpha -0.065 0.16 -10000 0 -0.8 13 13
positive regulation of T cell mediated cytotoxicity 0.16 0.43 1 63 -0.84 13 76
ITGA3 0.066 0.46 0.97 28 -1.1 36 64
IL17F 0.063 0.27 0.67 41 -0.62 5 46
IL12B 0.047 0.099 0.28 63 -10000 0 63
STAT1 (dimer) 0.2 0.38 0.87 69 -0.82 9 78
CD4 0.14 0.38 0.98 42 -1.3 1 43
IL23 0.11 0.34 0.84 40 -10000 0 40
IL23R 0.093 0.21 0.77 27 -10000 0 27
IL1B 0.14 0.39 1 40 -10000 0 40
T-helper cell lineage commitment 0 0 -10000 0 -10000 0 0
IL24 0.13 0.36 0.93 40 -10000 0 40
TYK2 0.028 0.065 0.23 29 -10000 0 29
STAT4 -0.004 0.018 0.24 3 -10000 0 3
STAT3 -0.012 0.04 -10000 0 -0.31 10 10
IL18RAP -0.004 0.014 -10000 0 -10000 0 0
IL12RB1 0.028 0.065 0.23 27 -10000 0 27
PIK3CA 0.047 0.1 0.24 122 -10000 0 122
IL12Rbeta1/TYK2 0.031 0.072 0.22 41 -10000 0 41
IL23R/JAK2 0.1 0.21 0.57 64 -10000 0 64
positive regulation of chronic inflammatory response 0.16 0.43 1 63 -0.84 13 76
natural killer cell activation -0.008 0.018 -10000 0 -0.062 33 33
JAK2 0.047 0.1 0.28 65 -0.33 2 67
PIK3R1 -0.076 0.13 -10000 0 -0.31 131 131
NFKB1 -0.003 0.037 -10000 0 -0.31 7 7
RELA 0.001 0.018 -10000 0 -0.32 1 1
positive regulation of dendritic cell antigen processing and presentation 0.11 0.33 0.83 40 -10000 0 40
ALOX12B 0.13 0.36 0.93 40 -10000 0 40
CXCL1 0.13 0.41 0.98 46 -1.2 9 55
T cell proliferation 0.16 0.43 1 63 -0.84 13 76
NFKBIA -0.006 0.048 -10000 0 -0.31 13 13
IL17A 0.079 0.26 0.6 54 -0.54 1 55
PI3K -0.04 0.21 0.5 23 -0.81 14 37
IFNG 0.031 0.068 0.26 37 -10000 0 37
STAT3 (dimer) -0.048 0.2 0.45 14 -0.82 13 27
IL18R1 -0.004 0.017 0.24 1 -10000 0 1
IL23/IL23R/JAK2/TYK2/SOCS3 0.12 0.3 0.74 63 -0.69 1 64
IL18/IL18R 0.035 0.075 0.19 77 -10000 0 77
macrophage activation -0.002 0.015 0.057 18 -10000 0 18
TNF 0.14 0.37 0.98 40 -10000 0 40
STAT3/STAT4 -0.062 0.16 0.47 1 -0.8 14 15
STAT4 (dimer) 0.11 0.34 0.8 40 -0.82 13 53
IL18 0.043 0.098 0.24 108 -10000 0 108
IL19 0.13 0.36 0.94 40 -10000 0 40
STAT5A (dimer) 0.11 0.34 0.81 38 -0.82 13 51
STAT1 0.13 0.12 0.24 314 -10000 0 314
SOCS3 -0.006 0.023 0.24 2 -0.31 2 4
CXCL9 0.18 0.42 1 61 -10000 0 61
MPO 0.13 0.36 0.93 40 -10000 0 40
positive regulation of humoral immune response 0.16 0.43 1 63 -0.84 13 76
IL23/IL23R/JAK2/TYK2 0.16 0.43 1 63 -0.86 13 76
IL6 0.12 0.39 0.92 43 -1.2 8 51
STAT5A -0.01 0.036 -10000 0 -0.31 8 8
IL2 -0.003 0.035 0.14 24 -10000 0 24
positive regulation of tyrosine phosphorylation of STAT protein -0.008 0.018 -10000 0 -0.062 33 33
CD3E 0.13 0.38 0.96 41 -1.2 3 44
keratinocyte proliferation 0.16 0.43 1 63 -0.84 13 76
NOS2 0.13 0.36 0.84 63 -0.77 13 76
Signaling events mediated by the Hedgehog family

Figure S39.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S39.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TGFB2 0.044 0.2 0.46 90 -0.46 25 115
IHH 0.007 0.055 0.19 1 -0.14 8 9
SHH Np/Cholesterol/GAS1 -0.03 0.056 0.13 1 -0.16 86 87
LRPAP1 -0.006 0.025 0.24 3 -0.31 2 5
dorsoventral neural tube patterning 0.03 0.056 0.16 86 -0.13 1 87
SMO/beta Arrestin2 0.016 0.11 -10000 0 -0.44 8 8
SMO 0.02 0.12 -10000 0 -0.46 8 8
AKT1 -0.022 0.14 0.24 24 -0.27 93 117
ARRB2 -0.006 0 -10000 0 -10000 0 0
BOC -0.036 0.091 -10000 0 -0.31 57 57
ADRBK1 -0.006 0 -10000 0 -10000 0 0
heart looping 0.02 0.12 -10000 0 -0.46 8 8
STIL 0.12 0.12 0.32 92 -10000 0 92
DHH N/PTCH2 -0.007 0 -10000 0 -10000 0 0
DHH N/PTCH1 -0.02 0.056 -10000 0 -0.36 8 8
PIK3CA 0.047 0.1 0.24 122 -10000 0 122
DHH -0.006 0 -10000 0 -10000 0 0
PTHLH 0.039 0.19 0.41 90 -0.46 25 115
determination of left/right symmetry 0.02 0.12 -10000 0 -0.46 8 8
PIK3R1 -0.075 0.13 -10000 0 -0.31 131 131
skeletal system development 0.04 0.18 0.41 90 -0.46 25 115
IHH N/Hhip 0.005 0.039 0.2 4 -10000 0 4
DHH N/Hhip -0.006 0.015 0.17 4 -10000 0 4
mol:Cholesterol 0 0 -10000 0 -10000 0 0
heart development 0.02 0.12 -10000 0 -0.46 8 8
pancreas development -0.004 0.021 0.24 4 -10000 0 4
HHAT -0.01 0.033 -10000 0 -0.31 7 7
PI3K -0.015 0.12 0.17 98 -0.21 107 205
EntrezGene:84976 0 0 -10000 0 -10000 0 0
GAS1 -0.049 0.11 -10000 0 -0.31 81 81
somite specification 0.02 0.12 -10000 0 -0.46 8 8
SHH Np/Cholesterol/PTCH1 0.014 0.1 0.22 89 -0.32 8 97
SHH Np/Cholesterol/PTCH2 -0.009 0.018 0.13 1 -0.16 7 8
SHH Np/Cholesterol/Megalin 0.03 0.07 0.15 139 -0.16 5 144
SHH -0.009 0.024 0.2 1 -0.21 7 8
catabolic process 0.026 0.13 0.3 90 -0.4 8 98
SMO/Vitamin D3 0.014 0.11 -10000 0 -0.41 8 8
SHH Np/Cholesterol/Hhip -0.008 0.022 0.15 5 -0.16 7 12
LRP2 0.056 0.11 0.24 141 -10000 0 141
receptor-mediated endocytosis 0.034 0.11 0.3 17 -0.43 8 25
SHH Np/Cholesterol/BOC -0.024 0.049 0.13 1 -0.16 63 64
SHH Np/Cholesterol/CDO -0.007 0.026 0.15 8 -0.16 9 17
mesenchymal cell differentiation 0.008 0.022 0.16 7 -0.14 5 12
mol:Vitamin D3 0.016 0.11 0.23 89 -0.32 8 97
IHH N/PTCH2 0.003 0.035 -10000 0 -10000 0 0
CDON -0.004 0.033 0.24 7 -0.31 2 9
IHH N/PTCH1 0.024 0.13 0.28 90 -0.4 8 98
Megalin/LRPAP1 0.037 0.078 0.17 144 -0.21 2 146
PTCH2 -0.006 0 -10000 0 -10000 0 0
SHH Np/Cholesterol -0.007 0.017 -10000 0 -0.16 7 7
PTCH1 0.027 0.14 0.3 90 -0.4 8 98
HHIP -0.004 0.021 0.24 4 -10000 0 4
Effects of Botulinum toxin

Figure S40.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S40.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
STX1A -0.003 0 -10000 0 -10000 0 0
UniProt:P19321 0 0 -10000 0 -10000 0 0
RIMS1/UNC13B -0.007 0 -10000 0 -10000 0 0
STXBP1 -0.038 0.093 -10000 0 -0.31 61 61
ACh/CHRNA1 -0.04 0.049 0.14 26 -10000 0 26
RAB3GAP2/RIMS1/UNC13B 0.011 0.017 0.16 8 -10000 0 8
mol:Ca2+ 0 0 -10000 0 -10000 0 0
UniProt:P30996 0 0 -10000 0 -10000 0 0
UniProt:Q60393 0 0 -10000 0 -10000 0 0
CST086 0 0 -10000 0 -10000 0 0
RIMS1 -0.006 0 -10000 0 -10000 0 0
mol:ACh -0.062 0.038 0.069 1 -0.085 412 413
RAB3GAP2 -0.002 0.029 0.24 8 -10000 0 8
STX1A/SNAP25/VAMP2 -0.11 0.07 0.1 1 -0.25 55 56
UniProt:P10844 0 0 -10000 0 -10000 0 0
muscle contraction -0.04 0.049 0.14 26 -10000 0 26
UNC13B -0.006 0 -10000 0 -10000 0 0
CHRNA1 0.006 0.052 0.24 26 -10000 0 26
UniProt:P10845 0 0 -10000 0 -10000 0 0
ACh/Synaptotagmin 1 -0.041 0.048 0.14 24 -10000 0 24
SNAP25 0.001 0.016 0.14 8 -10000 0 8
VAMP2 -0.15 0.087 -10000 0 -0.2 419 419
SYT1 0.005 0.05 0.24 24 -10000 0 24
UniProt:Q00496 0 0 -10000 0 -10000 0 0
STXIA/STXBP1 -0.024 0.052 -10000 0 -0.18 61 61
STX1A/SNAP25 fragment 1/VAMP2 -0.11 0.07 0.1 1 -0.25 55 56
p75(NTR)-mediated signaling

Figure S41.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S41.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Sortilin/TRAF6 -0.004 0.021 0.17 8 -10000 0 8
Necdin/E2F1 -0.12 0.1 -10000 0 -0.21 321 321
proNGF (dimer)/p75(NTR)/Sortilin/NADE/14-3-3 E 0.011 0.02 0.14 7 -0.15 4 11
NGF (dimer)/p75(NTR)/BEX1 -0.046 0.095 0.15 28 -0.18 185 213
NT-4/5 (dimer)/p75(NTR) -0.003 0.007 0.17 1 -10000 0 1
IKBKB -0.005 0.015 0.24 2 -10000 0 2
AKT1 -0.013 0.081 0.12 99 -0.15 106 205
IKBKG -0.006 0 -10000 0 -10000 0 0
BDNF -0.006 0 -10000 0 -10000 0 0
MGDIs/NGR/p75(NTR)/LINGO1 0.01 0.012 0.16 4 -10000 0 4
FURIN -0.011 0.038 -10000 0 -0.31 9 9
proBDNF (dimer)/p75(NTR)/Sortilin 0.011 0.016 0.16 7 -10000 0 7
LINGO1 -0.004 0.023 0.24 5 -10000 0 5
Sortilin/TRAF6/NRIF -0.033 0.044 -10000 0 -0.26 1 1
proBDNF (dimer) -0.006 0 -10000 0 -10000 0 0
NTRK1 -0.006 0 -10000 0 -10000 0 0
RTN4R -0.005 0.01 0.24 1 -10000 0 1
neuron apoptosis -0.008 0.076 0.2 1 -10000 0 1
IRAK1 -0.004 0.018 0.24 3 -10000 0 3
SHC1 -0.005 0.007 0.15 1 -10000 0 1
ARHGDIA -0.049 0.11 -10000 0 -0.31 81 81
RhoA/GTP -0.004 0.012 -10000 0 -0.21 2 2
Gamma Secretase -0.01 0.059 -10000 0 -0.15 79 79
proNGF (dimer)/p75(NTR)/Sortilin/MAGE-H1 0.005 0.032 0.15 6 -0.16 17 23
MAGEH1 -0.015 0.053 -10000 0 -0.31 18 18
proNGF (dimer)/p75(NTR)/Sortilin/Necdin -0.084 0.083 0.15 1 -0.16 315 316
Mammalian IAPs/DIABLO 0.066 0.12 0.18 240 -0.16 53 293
proNGF (dimer) 0 0 -10000 0 -10000 0 0
MAGED1 -0.007 0.024 0.24 1 -0.31 3 4
APP -0.011 0.038 -10000 0 -0.31 9 9
NT-4/5 (dimer) 0 0 -10000 0 -10000 0 0
ZNF274 -0.006 0 -10000 0 -10000 0 0
RhoA/GDP/RHOGDI -0.027 0.051 0.12 1 -0.15 82 83
NGF 0 0 -10000 0 -10000 0 0
cell cycle arrest 0.025 0.047 0.18 6 -10000 0 6
NGF (dimer)/p75(NTR)/TRAF6/RIP2/IRAK 0.033 0.053 0.22 2 -10000 0 2
NT-4/5 (dimer)/p75(NTR)/TRAF6 0.007 0.011 0.15 3 -10000 0 3
NCSTN -0.005 0.01 0.24 1 -10000 0 1
mol:GTP 0.009 0.02 0.15 11 -10000 0 11
PSENEN -0.016 0.054 -10000 0 -0.31 19 19
mol:ceramide -0.007 0.023 0.13 7 -0.16 7 14
NGF (dimer)/p75(NTR)/TRAF6/RIP2/IRAK/p62/Atypical PKCs 0.071 0.068 0.18 100 -10000 0 100
p75(NTR)/beta APP -0.01 0.027 0.17 1 -0.21 9 10
BEX1 -0.092 0.16 0.24 27 -0.31 185 212
mol:GDP -0.002 0.006 0.15 1 -10000 0 1
NGF (dimer) -0.052 0.093 0.15 21 -0.16 216 237
MGDIs/NGR/p75(NTR)/LINGO1/RHOGDI -0.012 0.062 0.15 4 -0.16 81 85
PIK3R1 -0.075 0.13 -10000 0 -0.31 131 131
RAC1/GTP 0.005 0.008 0.14 1 -0.15 1 2
MYD88 -0.006 0 -10000 0 -10000 0 0
CHUK 0.002 0.043 0.24 18 -10000 0 18
NGF (dimer)/p75(NTR)/PKA 0.009 0.02 0.15 11 -10000 0 11
RHOB -0.012 0.042 -10000 0 -0.31 11 11
RHOA -0.007 0.018 -10000 0 -0.31 2 2
MAGE-G1/E2F1 -0.008 0.012 -10000 0 -0.21 2 2
NT3 (dimer) 0.029 0.086 0.24 80 -10000 0 80
TP53 -0.031 0.051 0.14 1 -10000 0 1
PRDM4 -0.006 0.015 0.13 7 -10000 0 7
BDNF (dimer) -0.046 0.094 0.15 28 -0.16 209 237
PIK3CA 0.047 0.1 0.24 122 -10000 0 122
SORT1 -0.003 0.025 0.24 6 -10000 0 6
activation of caspase activity 0.01 0.019 0.13 7 -0.15 4 11
proNGF (dimer)/p75(NTR)/Sortilin/TRAF6 0.011 0.017 0.15 9 -10000 0 9
RHOC -0.006 0 -10000 0 -10000 0 0
XIAP 0 0 -10000 0 -10000 0 0
MAPK10 -0.017 0.036 -10000 0 -10000 0 0
DIABLO 0.077 0.12 0.24 190 -10000 0 190
SMPD2 -0.007 0.023 0.13 7 -0.16 7 14
APH1B -0.038 0.093 -10000 0 -0.31 61 61
APH1A -0.005 0.01 0.24 1 -10000 0 1
proNGF (dimer)/p75(NTR)/Sortilin 0.008 0.016 0.15 7 -10000 0 7
PSEN1 -0.005 0.01 0.24 1 -10000 0 1
APAF-1/Pro-Caspase 9 -0.001 0.031 0.17 18 -10000 0 18
NT3 (dimer)/p75(NTR) 0.018 0.062 0.17 81 -10000 0 81
MAPK8 -0.012 0.029 -10000 0 -10000 0 0
MAPK9 -0.013 0.028 -10000 0 -10000 0 0
APAF1 0.002 0.042 0.24 17 -10000 0 17
NTF3 0.029 0.086 0.24 80 -10000 0 80
NTF4 0 0 -10000 0 -10000 0 0
NDN -0.18 0.15 -10000 0 -0.31 321 321
RAC1/GDP -0.004 0.009 -10000 0 -0.21 1 1
RhoA-B-C/GDP -0.013 0.02 -10000 0 -0.14 13 13
p75 CTF/Sortilin/TRAF6/NRIF 0.038 0.057 0.15 108 -10000 0 108
RhoA-B-C/GTP 0.009 0.02 0.15 11 -10000 0 11
proBDNF (dimer)/p75(NTR)/Sortilin/TRAF6/NRIF 0.015 0.016 -10000 0 -10000 0 0
proBDNF (dimer)/p75(NTR)/Sortilin/TRAF6 0.013 0.017 0.15 9 -10000 0 9
PRKACB -0.001 0.033 0.24 10 -10000 0 10
proBDNF (dimer)/p75 ECD 0.025 0.068 0.17 102 -10000 0 102
ChemicalAbstracts:86-01-1 0 0 -10000 0 -10000 0 0
BIRC3 -0.047 0.12 0.24 16 -0.31 90 106
BIRC2 0.059 0.11 0.24 149 -10000 0 149
neuron projection morphogenesis -0.025 0.07 0.15 6 -0.21 10 16
BAD -0.015 0.03 -10000 0 -10000 0 0
RIPK2 0.073 0.12 0.24 180 -10000 0 180
NGFR -0.005 0.01 0.24 1 -10000 0 1
CYCS -0.007 0.022 0.13 12 -0.15 3 15
ADAM17 0.039 0.095 0.24 102 -10000 0 102
NGF (dimer)/p75(NTR)/TRAF6/RIP2 0.053 0.066 0.15 182 -10000 0 182
BCL2L11 -0.015 0.03 -10000 0 -10000 0 0
BDNF (dimer)/p75(NTR) -0.007 0.007 0.17 1 -10000 0 1
PI3K 0 0.093 0.15 99 -0.16 107 206
proNGF (dimer)/p75(NTR)/Sortilin/MAGE-G1 0.009 0.018 0.15 7 -0.16 2 9
NDNL2 -0.007 0.018 -10000 0 -0.31 2 2
YWHAE -0.006 0.013 -10000 0 -0.31 1 1
PRKCI 0.1 0.12 0.24 255 -10000 0 255
NGF (dimer)/p75(NTR) -0.003 0.007 0.17 1 -10000 0 1
ChemicalAbstracts:146-91-8 0 0 -10000 0 -10000 0 0
proNGF (dimer)/p75(NTR)/Sortilin/NRAGE 0.009 0.021 0.15 8 -0.16 3 11
TRAF6 -0.005 0.015 0.24 2 -10000 0 2
RAC1 -0.006 0.013 -10000 0 -0.31 1 1
PRKCZ -0.006 0 -10000 0 -10000 0 0
PLG -0.013 0.047 -10000 0 -0.31 14 14
oligodendrocyte cell fate commitment 0 0 -10000 0 -10000 0 0
CASP6 0.031 0.063 0.13 154 -10000 0 154
SQSTM1 -0.006 0 -10000 0 -10000 0 0
NGFRAP1 -0.007 0.022 -10000 0 -0.31 3 3
CASP3 -0.014 0.029 -10000 0 -10000 0 0
E2F1 -0.006 0 -10000 0 -10000 0 0
CASP9 -0.005 0.01 0.24 1 -10000 0 1
IKK complex -0.003 0.012 -10000 0 -10000 0 0
NGF (dimer)/TRKA -0.003 0 -10000 0 -10000 0 0
MMP7 -0.1 0.16 0.24 21 -0.31 200 221
proNGF (dimer)/p75(NTR)/Sortilin/TRAF6/NRIF 0.012 0.016 0.14 9 -10000 0 9
MMP3 -0.001 0.033 0.24 10 -10000 0 10
APAF-1/Caspase 9 -0.02 0.037 -10000 0 -10000 0 0
FoxO family signaling

Figure S42.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S42.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
G6PC 0.043 0.067 -10000 0 -10000 0 0
PLK1 0.22 0.31 0.71 71 -0.56 1 72
CDKN1B 0.14 0.24 0.53 68 -0.45 3 71
FOXO3 0.2 0.3 0.63 83 -0.49 16 99
KAT2B 0.043 0.053 0.092 202 -10000 0 202
FOXO1/SIRT1 0.004 0.051 -10000 0 -0.23 1 1
CAT 0.18 0.3 0.68 41 -0.86 8 49
CTNNB1 -0.005 0.015 0.24 2 -10000 0 2
AKT1 0.044 0.059 0.18 40 -10000 0 40
FOXO1 0.05 0.077 -10000 0 -10000 0 0
MAPK10 0.011 0.043 0.15 7 -0.16 7 14
mol:GTP 0 0.006 -10000 0 -10000 0 0
FOXO4 0.012 0.13 0.35 30 -0.42 4 34
response to oxidative stress 0.042 0.054 0.13 78 -10000 0 78
FOXO3A/SIRT1 0.091 0.26 0.58 53 -0.44 35 88
XPO1 0.015 0.067 0.24 46 -10000 0 46
EP300 -0.001 0.02 -10000 0 -0.31 2 2
BCL2L11 0.06 0.075 0.6 1 -10000 0 1
FOXO1/SKP2 0.082 0.11 0.26 94 -10000 0 94
mol:GDP 0.042 0.054 0.13 78 -10000 0 78
RAN -0.005 0.007 -10000 0 -10000 0 0
GADD45A 0.14 0.23 0.62 60 -10000 0 60
YWHAQ -0.006 0 -10000 0 -10000 0 0
FOXO1/14-3-3 family 0.018 0.033 -10000 0 -10000 0 0
MST1 0.044 0.058 0.17 40 -10000 0 40
CSNK1D -0.006 0 -10000 0 -10000 0 0
CSNK1E -0.006 0 -10000 0 -10000 0 0
FOXO4/14-3-3 family 0.005 0.035 -10000 0 -0.26 3 3
YWHAB -0.005 0.01 0.24 1 -10000 0 1
MAPK8 0.015 0.042 0.16 6 -10000 0 6
MAPK9 0.013 0.04 0.15 7 -10000 0 7
YWHAG -0.006 0 -10000 0 -10000 0 0
YWHAE -0.006 0.013 -10000 0 -0.31 1 1
YWHAZ -0.006 0 -10000 0 -10000 0 0
SIRT1 -0.005 0.025 -10000 0 -10000 0 0
SOD2 0.012 0.43 0.52 63 -0.76 112 175
RBL2 0.16 0.23 0.56 40 -0.89 1 41
RAL/GDP 0.031 0.045 0.2 5 -10000 0 5
CHUK 0.051 0.068 0.2 56 -10000 0 56
Ran/GTP -0.002 0.012 -10000 0 -10000 0 0
CSNK1G2 -0.006 0 -10000 0 -10000 0 0
RAL/GTP 0.03 0.052 0.17 32 -10000 0 32
CSNK1G1 -0.006 0 -10000 0 -10000 0 0
FASLG 0.06 0.072 -10000 0 -10000 0 0
SKP2 0.059 0.11 0.24 149 -10000 0 149
USP7 -0.004 0.016 0.25 2 -10000 0 2
IKBKB 0.044 0.058 0.18 41 -10000 0 41
CCNB1 0.3 0.33 0.57 285 -0.56 1 286
FOXO1-3a-4/beta catenin 0.09 0.25 0.49 67 -0.43 5 72
proteasomal ubiquitin-dependent protein catabolic process 0.082 0.1 0.26 94 -10000 0 94
CSNK1A1 -0.005 0.015 0.24 2 -10000 0 2
SGK1 0.043 0.053 0.092 202 -10000 0 202
CSNK1G3 -0.006 0 -10000 0 -10000 0 0
Ran/GTP/Exportin 1 0.009 0.043 0.16 39 -10000 0 39
ZFAND5 0.013 0.12 0.4 4 -0.85 1 5
SFN 0.003 0.047 0.24 21 -10000 0 21
CDK2 0.091 0.12 0.24 229 -10000 0 229
FOXO3A/14-3-3 0.067 0.087 0.24 45 -0.32 2 47
CREBBP -0.016 0.042 -10000 0 -0.31 11 11
FBXO32 -0.072 0.57 0.68 43 -0.86 171 214
BCL6 0.14 0.29 0.56 39 -1 14 53
RALB -0.006 0.007 -10000 0 -10000 0 0
RALA -0.005 0.016 0.24 2 -10000 0 2
YWHAH -0.007 0.022 -10000 0 -0.31 3 3
Signaling mediated by p38-gamma and p38-delta

Figure S43.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S43.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
EEF2K -0.008 0.014 0.16 2 -0.18 2 4
SNTA1 -0.006 0 -10000 0 -10000 0 0
response to hypoxia 0 0 -10000 0 -10000 0 0
STMN1 0.04 0.078 0.16 163 -0.18 2 165
MAPK12 0.01 0.061 0.14 82 -0.19 16 98
CCND1 -0.092 0.17 -10000 0 -0.37 150 150
p38 gamma/SNTA1 0.006 0.055 0.22 1 -0.18 16 17
MAP2K3 -0.007 0.018 -10000 0 -0.31 2 2
PKN1 -0.004 0.028 0.24 6 -0.31 1 7
G2/M transition checkpoint 0.01 0.061 0.14 82 -0.19 16 98
MAP2K6 0.015 0.07 0.16 82 -0.21 16 98
MAPT 0.002 0.028 0.16 2 -0.16 2 4
MAPK13 -0.007 0.017 0.2 2 -0.21 2 4
hyperosmotic response 0 0 -10000 0 -10000 0 0
ZAK -0.007 0.042 0.16 5 -0.24 16 21
Retinoic acid receptors-mediated signaling

Figure S44.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S44.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
HDAC1 0.01 0.06 0.24 36 -10000 0 36
HDAC3 -0.006 0 -10000 0 -10000 0 0
VDR -0.005 0.01 0.24 1 -10000 0 1
Cbp/p300/PCAF 0.002 0.027 -10000 0 -0.18 13 13
EP300 -0.007 0.018 -10000 0 -0.31 2 2
RARs/AIB1/Cbp/p300/PCAF/9cRA -0.024 0.045 0.18 1 -0.22 7 8
KAT2B 0 0 -10000 0 -10000 0 0
MAPK14 -0.005 0.01 0.24 1 -10000 0 1
AKT1 0.019 0.08 0.22 9 -10000 0 9
RAR alpha/9cRA/Cyclin H -0.051 0.078 0.17 11 -0.26 17 28
mol:9cRA 0 0 -10000 0 -10000 0 0
RARs/Src-1/Cbp/p300/PCAF/9cRA -0.028 0.048 -10000 0 -0.23 10 10
CDC2 0.23 0.046 0.24 549 -10000 0 549
response to UV -0.01 0.013 -10000 0 -10000 0 0
RAR alpha/Jnk1 -0.03 0.05 0.19 5 -10000 0 5
NCOR2 -0.011 0.038 -10000 0 -0.31 9 9
VDR/VDR/Vit D3 -0.003 0.007 0.17 1 -10000 0 1
RXRs/RARs/NRIP1/9cRA -0.16 0.26 -10000 0 -0.49 216 216
NCOA2 -0.005 0.015 0.24 2 -10000 0 2
NCOA3 -0.003 0.027 0.24 7 -10000 0 7
NCOA1 -0.007 0.018 -10000 0 -0.31 2 2
VDR/VDR/DNA -0.005 0.01 0.24 1 -10000 0 1
RARG -0.006 0.034 0.23 11 -10000 0 11
RAR gamma1/9cRA 0.001 0.018 0.15 6 -10000 0 6
MAPK3 -0.021 0.048 -10000 0 -0.32 14 14
MAPK1 -0.006 0.016 0.24 1 -0.31 1 2
MAPK8 -0.013 0.029 0.24 6 -10000 0 6
mol:Vit D3 0 0 -10000 0 -10000 0 0
RXRs/VDR/DNA/Vit D3 -0.062 0.15 -10000 0 -0.34 22 22
RARA -0.037 0.052 -10000 0 -0.2 4 4
negative regulation of phosphoinositide 3-kinase cascade 0 0 -10000 0 -10000 0 0
RARs/TIF2/Cbp/p300/PCAF/9cRA -0.027 0.048 -10000 0 -0.23 10 10
PRKCA -0.027 0.045 0.2 7 -0.31 4 11
RXRs/RARs/NRIP1/9cRA/HDAC1 -0.18 0.28 -10000 0 -0.53 218 218
RXRG -0.037 0.061 -10000 0 -0.26 6 6
RXRA 0.02 0.092 0.2 4 -0.28 13 17
RXRB -0.039 0.05 -10000 0 -0.24 4 4
VDR/Vit D3/DNA -0.003 0.007 0.17 1 -10000 0 1
RBP1 -0.098 0.14 -10000 0 -0.31 174 174
CRBP1/9-cic-RA -0.066 0.095 -10000 0 -0.21 174 174
RARB -0.01 0.039 0.23 13 -10000 0 13
PRKCG -0.027 0.027 -10000 0 -10000 0 0
MNAT1 -0.006 0 -10000 0 -10000 0 0
RAR alpha/RXRs -0.048 0.18 0.27 4 -0.31 136 140
RXRs/RARs/SMRT(N-CoR2)/9cRA -0.065 0.14 -10000 0 -0.34 22 22
proteasomal ubiquitin-dependent protein catabolic process -0.038 0.057 -10000 0 -0.24 7 7
RXRs/RARs/NRIP1/9cRA/HDAC3 -0.18 0.28 -10000 0 -0.53 218 218
positive regulation of DNA binding -0.052 0.068 -10000 0 -0.24 17 17
NRIP1 -0.38 0.52 -10000 0 -1 218 218
RXRs/RARs -0.13 0.21 -10000 0 -0.39 218 218
RXRs/RXRs/DNA/9cRA -0.064 0.16 -10000 0 -0.34 22 22
PRKACA -0.006 0 -10000 0 -10000 0 0
CDK7 0.002 0.044 0.24 19 -10000 0 19
TFIIH 0.014 0.027 0.16 20 -10000 0 20
RAR alpha/9cRA -0.028 0.041 0.12 14 -10000 0 14
CCNH -0.005 0.01 0.24 1 -10000 0 1
CREBBP -0.012 0.042 -10000 0 -0.31 11 11
RAR gamma2/9cRA -0.013 0.004 -10000 0 -10000 0 0
Syndecan-4-mediated signaling events

Figure S45.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S45.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PTK2 0.064 0.12 0.24 54 -0.4 13 67
Syndecan-4/Syndesmos 0.05 0.09 0.24 48 -10000 0 48
positive regulation of JNK cascade 0.012 0.093 0.27 8 -0.3 10 18
Syndecan-4/ADAM12 0.084 0.13 0.29 135 -10000 0 135
CCL5 -0.029 0.088 0.24 6 -0.31 48 54
Rac1/GDP -0.004 0.009 -10000 0 -0.21 1 1
DNM2 -0.005 0.01 0.24 1 -10000 0 1
ITGA5 -0.003 0.025 0.24 6 -10000 0 6
SDCBP -0.006 0.023 0.24 2 -0.31 2 4
PLG -0.018 0.046 -10000 0 -0.3 14 14
ADAM12 0.051 0.1 0.24 130 -10000 0 130
mol:GTP 0 0 -10000 0 -10000 0 0
NUDT16L1 -0.006 0 -10000 0 -10000 0 0
mol:PI-4-5-P2 0 0 -10000 0 -10000 0 0
Syndecan-4/PKC alpha -0.006 0.006 -10000 0 -10000 0 0
Syndecan-4/Laminin alpha1 0.075 0.1 0.26 71 -10000 0 71
Syndecan-4/CXCL12/CXCR4 0.032 0.11 0.24 54 -0.31 10 64
Syndecan-4/Laminin alpha3 0.048 0.093 0.25 47 -0.3 4 51
MDK -0.005 0.01 0.24 1 -10000 0 1
Syndecan-4/FZD7 0.056 0.094 0.25 54 -10000 0 54
Syndecan-4/Midkine 0.051 0.09 0.24 48 -10000 0 48
FZD7 0.004 0.048 0.24 22 -10000 0 22
Syndecan-4/FGFR1/FGF 0.009 0.067 -10000 0 -0.29 3 3
THBS1 -0.036 0.1 0.24 8 -0.31 64 72
integrin-mediated signaling pathway 0.089 0.13 0.28 126 -10000 0 126
positive regulation of MAPKKK cascade 0.012 0.093 0.27 8 -0.3 10 18
Syndecan-4/TACI 0.05 0.09 0.24 48 -10000 0 48
CXCR4 -0.007 0.035 0.24 4 -0.31 5 9
cell adhesion 0.039 0.076 0.19 16 -0.21 13 29
Syndecan-4/Dynamin 0.051 0.09 0.24 48 -10000 0 48
Syndecan-4/TSP1 0.049 0.1 0.25 53 -0.3 9 62
Syndecan-4/GIPC 0.053 0.091 0.25 51 -10000 0 51
Syndecan-4/RANTES 0.05 0.098 0.26 50 -0.3 7 57
ITGB1 -0.003 0.025 0.24 6 -10000 0 6
LAMA1 0.036 0.093 0.24 96 -10000 0 96
LAMA3 -0.025 0.083 0.24 6 -0.31 41 47
RAC1 -0.006 0.013 -10000 0 -0.31 1 1
PRKCA -0.022 0.057 0.34 7 -0.28 4 11
Syndecan-4/alpha-Actinin 0.049 0.093 0.24 47 -0.3 4 51
TFPI -0.024 0.076 0.24 3 -0.31 36 39
F2 -0.002 0.017 0.27 1 -10000 0 1
alpha5/beta1 Integrin -0.003 0.025 0.17 12 -10000 0 12
positive regulation of cell adhesion 0.062 0.1 0.25 71 -0.3 1 72
ACTN1 -0.012 0.042 -10000 0 -0.31 11 11
TNC 0.062 0.11 0.24 155 -10000 0 155
Syndecan-4/CXCL12 0.05 0.098 0.25 52 -0.3 9 61
FGF6 -0.006 0 -10000 0 -10000 0 0
RHOA -0.007 0.018 -10000 0 -0.31 2 2
CXCL12 -0.045 0.11 0.24 9 -0.31 81 90
TNFRSF13B -0.006 0 -10000 0 -10000 0 0
FGF2 -0.011 0.04 -10000 0 -0.31 10 10
FGFR1 -0.015 0.057 0.24 3 -0.31 19 22
Syndecan-4/PI-4-5-P2 0.05 0.088 0.24 48 -10000 0 48
mol:GDP 0 0 -10000 0 -10000 0 0
FN1 0.08 0.13 0.25 200 -0.29 12 212
cell migration -0.003 0.003 -10000 0 -10000 0 0
PRKCD -0.011 0.023 0.25 1 -0.3 2 3
vasculogenesis 0.048 0.098 0.25 53 -0.29 9 62
SDC4 0.055 0.094 0.26 48 -10000 0 48
Syndecan-4/Tenascin C 0.09 0.13 0.29 125 -10000 0 125
Syndecan-4/PI-4-5-P2/PKC alpha -0.005 0.005 -10000 0 -10000 0 0
Syndecan-4/Syntenin 0.051 0.091 0.24 48 -0.3 1 49
MMP9 0.034 0.094 0.25 92 -10000 0 92
Rac1/GTP 0.039 0.077 0.19 16 -0.22 13 29
cytoskeleton organization 0.05 0.089 0.24 48 -10000 0 48
GIPC1 -0.002 0.029 0.24 8 -10000 0 8
Syndecan-4/TFPI 0.048 0.094 0.25 48 -0.3 5 53
Syndecan-2-mediated signaling events

Figure S46.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S46.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Syndecan-2/Fibronectin 0.048 0.096 0.17 204 -0.18 25 229
EPHB2 -0.001 0.033 0.24 10 -10000 0 10
Syndecan-2/TACI -0.009 0.031 0.14 6 -0.18 15 21
LAMA1 0.036 0.093 0.24 96 -10000 0 96
Syndecan-2/alpha2 ITGB1 -0.024 0.061 0.14 18 -0.16 73 91
HRAS -0.006 0 -10000 0 -10000 0 0
Syndecan-2/CASK -0.006 0.031 0.14 6 -0.17 15 21
ITGA5 -0.003 0.025 0.24 6 -10000 0 6
BAX -0.007 0.032 -10000 0 -10000 0 0
EPB41 0.006 0.052 0.24 26 -10000 0 26
positive regulation of cell-cell adhesion -0.008 0.031 0.13 8 -0.16 17 25
LAMA3 -0.025 0.083 0.24 6 -0.31 41 47
EZR 0 0 -10000 0 -10000 0 0
mol:PI-4-5-P2 0 0 -10000 0 -10000 0 0
CAV2 -0.017 0.06 0.24 2 -0.31 22 24
Syndecan-2/MMP2 -0.02 0.081 0.16 38 -0.19 80 118
RP11-540L11.1 0 0 -10000 0 -10000 0 0
alpha2 ITGB1 -0.013 0.045 0.17 6 -0.21 23 29
dendrite morphogenesis -0.006 0.039 0.16 16 -0.18 15 31
Syndecan-2/GM-CSF -0.009 0.031 0.14 6 -0.18 15 21
determination of left/right symmetry -0.007 0.039 0.2 6 -0.21 15 21
Syndecan-2/PKC delta -0.009 0.034 0.15 7 -0.18 17 24
GNB2L1 -0.006 0 -10000 0 -10000 0 0
MAPK3 -0.014 0.039 0.13 6 -0.18 26 32
MAPK1 -0.01 0.03 0.14 7 -0.16 16 23
Syndecan-2/RACK1 -0.009 0.027 0.12 6 -0.15 15 21
NF1 -0.02 0.063 -10000 0 -0.31 26 26
FGFR/FGF/Syndecan-2 -0.007 0.039 0.2 6 -0.21 15 21
ITGA2 -0.018 0.062 0.24 1 -0.31 24 25
MAPK8 -0.007 0.037 -10000 0 -10000 0 0
Syndecan-2/alpha2/beta1 Integrin 0.011 0.075 0.15 100 -0.16 33 133
Syndecan-2/Kininogen -0.009 0.032 0.15 7 -0.18 15 22
ITGB1 -0.003 0.025 0.24 6 -10000 0 6
SRC -0.011 0.025 -10000 0 -10000 0 0
Syndecan-2/CASK/Protein 4.1 -0.001 0.041 0.15 30 -0.16 13 43
extracellular matrix organization -0.035 0.072 0.14 6 -0.18 99 105
actin cytoskeleton reorganization 0.048 0.096 0.17 204 -0.18 25 229
Syndecan-2/Caveolin-2/Ras -0.015 0.042 0.14 7 -0.17 34 41
Syndecan-2/Laminin alpha3 -0.019 0.057 0.16 12 -0.18 55 67
Syndecan-2/RasGAP -0.012 0.027 0.12 6 -0.14 18 24
alpha5/beta1 Integrin -0.003 0.025 0.17 12 -10000 0 12
PRKCD -0.006 0.021 0.24 1 -0.31 2 3
Syndecan-2 dimer -0.006 0.039 0.16 16 -0.18 15 31
GO:0007205 0 0 -10000 0 -10000 0 0
DNA mediated transformation 0 0 -10000 0 -10000 0 0
Syndecan-2/RasGAP/Src -0.013 0.027 -10000 0 -10000 0 0
RHOA -0.007 0.018 -10000 0 -0.31 2 2
SDCBP -0.006 0.023 0.24 2 -0.31 2 4
TNFRSF13B -0.006 0 -10000 0 -10000 0 0
RASA1 -0.007 0.022 -10000 0 -0.31 3 3
alpha2/beta1 Integrin -0.013 0.045 0.17 6 -0.21 23 29
Syndecan-2/Synbindin 0.002 0.053 0.17 41 -0.18 14 55
TGFB1 -0.054 0.11 -10000 0 -0.31 90 90
CASP3 -0.008 0.036 0.14 16 -0.16 16 32
FN1 0.075 0.13 0.24 200 -0.31 12 212
Syndecan-2/IL8 0.008 0.061 0.17 61 -0.18 14 75
SDC2 -0.007 0.039 0.2 6 -0.21 15 21
KNG1 -0.005 0.01 0.24 1 -10000 0 1
Syndecan-2/Neurofibromin -0.017 0.045 0.14 4 -0.18 39 43
TRAPPC4 0.01 0.061 0.24 37 -10000 0 37
CSF2 -0.006 0 -10000 0 -10000 0 0
Syndecan-2/TGFB1 -0.036 0.072 0.14 6 -0.18 99 105
Syndecan-2/Syntenin/PI-4-5-P2 -0.008 0.031 0.13 8 -0.16 17 25
Syndecan-2/Ezrin -0.008 0.029 0.13 6 -0.16 17 23
PRKACA -0.017 0.04 0.13 4 -0.16 39 43
angiogenesis 0.008 0.061 0.17 61 -0.18 14 75
MMP2 -0.03 0.12 0.24 32 -0.31 71 103
IL8 0.019 0.074 0.24 57 -10000 0 57
calcineurin-NFAT signaling pathway -0.009 0.031 0.14 6 -0.18 15 21
Cellular roles of Anthrax toxin

Figure S47.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S47.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
ANTXR1 -0.013 0.052 0.24 2 -0.31 16 18
ANTXR2 -0.012 0.049 0.24 2 -0.31 14 16
negative regulation of myeloid dendritic cell antigen processing and presentation -0.003 0.01 -10000 0 -0.046 27 27
monocyte activation -0.028 0.14 0.27 1 -0.37 76 77
MAP2K2 -0.1 0.24 -10000 0 -0.66 92 92
MAP2K1 -0.005 0.011 0.13 1 -10000 0 1
MAP2K7 -0.005 0.009 -10000 0 -0.068 3 3
MAP2K6 0.014 0.048 0.13 82 -10000 0 82
CYAA -0.011 0.036 0.12 4 -0.16 27 31
MAP2K4 -0.007 0.018 -10000 0 -0.12 9 9
IL1B -0.002 0.042 0.12 40 -0.12 2 42
Channel -0.002 0.041 0.15 4 -0.17 27 31
NLRP1 -0.005 0.01 0.09 1 -0.068 3 4
CALM1 -0.012 0.042 -10000 0 -0.31 11 11
negative regulation of phagocytosis -0.011 0.065 -10000 0 -0.46 11 11
mol:Ca2+ 0 0 -10000 0 -10000 0 0
regulation of endothelial cell proliferation 0.003 0.01 0.046 27 -10000 0 27
MAPK3 -0.009 0.024 -10000 0 -0.15 14 14
MAPK1 -0.005 0.012 0.13 1 -0.15 1 2
PGR -0.14 0.037 -10000 0 -0.15 531 531
PA/Cellular Receptors -0.002 0.045 0.15 4 -0.19 27 31
apoptosis -0.003 0.01 -10000 0 -0.046 27 27
LOC728358 0 0 -10000 0 -10000 0 0
Lethal toxin (unfolded) -0.002 0.04 0.14 4 -0.17 27 31
macrophage activation -0.01 0.024 0.12 1 -0.14 15 16
TNF -0.005 0.01 0.24 1 -10000 0 1
VCAM1 -0.028 0.14 0.27 1 -0.37 76 77
platelet activation -0.011 0.065 -10000 0 -0.46 11 11
MAPKKK cascade 0.008 0.027 0.062 71 -10000 0 71
IL18 0.013 0.058 0.12 107 -0.12 2 109
negative regulation of macrophage activation -0.003 0.01 -10000 0 -0.046 27 27
LEF -0.003 0.01 -10000 0 -0.047 27 27
CASP1 -0.004 0.011 0.04 1 -0.05 24 25
mol:cAMP -0.011 0.065 -10000 0 -0.47 11 11
necrosis -0.003 0.01 -10000 0 -0.046 27 27
intracellular pH reduction 0 0 -10000 0 -10000 0 0
PAGA 0 0 -10000 0 -10000 0 0
Edema toxin (unfolded) -0.002 0.039 0.14 4 -0.16 27 31
mol:Epigallocatechin-3-gallate (EGCG) 0 0 -10000 0 -10000 0 0
HIF-2-alpha transcription factor network

Figure S48.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S48.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
MMP14 0.002 0.098 0.55 14 -0.98 1 15
oxygen homeostasis 0.024 0.043 0.19 16 -10000 0 16
TCEB2 -0.006 0 -10000 0 -10000 0 0
TCEB1 -0.006 0 -10000 0 -10000 0 0
VHL/Elongin B/Elongin C/HIF2A -0.011 0.11 0.39 1 -0.3 12 13
EPO 0.12 0.28 0.67 73 -10000 0 73
FIH (dimer) 0.023 0.045 0.19 13 -10000 0 13
APEX1 0.04 0.08 0.25 62 -10000 0 62
SERPINE1 0.15 0.33 0.76 83 -0.53 1 84
FLT1 -0.01 0.021 -10000 0 -10000 0 0
ADORA2A 0.13 0.3 0.67 76 -0.52 1 77
germ cell development 0.12 0.31 0.7 75 -0.62 2 77
SLC11A2 0.13 0.31 0.71 76 -0.53 1 77
BHLHE40 0.12 0.3 0.7 73 -0.53 1 74
HIF1AN 0.023 0.045 0.19 13 -10000 0 13
HIF2A/ARNT/SIRT1 0.006 0.15 0.42 7 -0.4 6 13
ETS1 -0.001 0.035 0.24 12 -10000 0 12
CITED2 -0.048 0.18 -10000 0 -0.84 27 27
KDR -0.009 0.033 0.6 1 -10000 0 1
PGK1 0.18 0.36 0.76 101 -0.53 1 102
SIRT1 -0.006 0 -10000 0 -10000 0 0
response to hypoxia 0 0 -10000 0 -10000 0 0
HIF2A/ARNT 0.14 0.33 0.77 72 -0.6 1 73
EPAS1 0.074 0.23 0.53 71 -0.38 6 77
SP1 0.002 0.045 0.24 19 -0.14 1 20
ABCG2 0.11 0.32 0.7 72 -0.57 11 83
EFNA1 0.13 0.32 0.72 78 -0.53 1 79
FXN 0.13 0.3 0.67 76 -0.52 1 77
POU5F1 0.12 0.31 0.7 74 -0.64 2 76
neuron apoptosis -0.14 0.33 0.58 1 -0.76 71 72
EP300 -0.007 0.018 -10000 0 -0.31 2 2
EGLN3 0.031 0.098 0.26 53 -0.3 16 69
EGLN2 0.024 0.047 0.19 16 -10000 0 16
EGLN1 0.023 0.045 0.19 14 -10000 0 14
VHL/Elongin B/Elongin C 0.01 0.011 0.16 3 -10000 0 3
VHL -0.004 0.018 0.24 3 -10000 0 3
ARNT 0.02 0.047 0.21 14 -10000 0 14
SLC2A1 0.14 0.31 0.71 80 -0.52 1 81
TWIST1 0.13 0.3 0.67 76 -0.52 1 77
ELK1 -0.011 0.021 -10000 0 -10000 0 0
HIF2A/ARNT/Cbp/p300 0.017 0.17 0.38 27 -0.4 6 33
VEGFA 0.14 0.32 0.74 81 -0.53 1 82
CREBBP -0.012 0.042 -10000 0 -0.31 11 11
IL2 signaling events mediated by PI3K

Figure S49.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S49.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BCL2L1 -0.031 0.092 0.6 1 -10000 0 1
UGCG -0.016 0.038 -10000 0 -0.59 1 1
AKT1/mTOR/p70S6K/Hsp90/TERT -0.09 0.15 -10000 0 -0.4 60 60
mol:GTP 0 0.001 -10000 0 -10000 0 0
mol:glucosylceramide -0.015 0.039 -10000 0 -0.58 1 1
mol:DAG -0.013 0.1 -10000 0 -0.88 8 8
CaM/Ca2+/Calcineurin A alpha-beta B1 -0.13 0.19 -10000 0 -0.44 130 130
FRAP1 -0.14 0.23 -10000 0 -0.54 110 110
FOXO3 -0.1 0.18 -10000 0 -0.48 75 75
AKT1 -0.11 0.19 -10000 0 -0.52 74 74
GAB2 -0.008 0.061 0.24 15 -0.31 13 28
SMPD1 -0.015 0.029 -10000 0 -10000 0 0
SGMS1 -0.024 0.086 -10000 0 -0.7 8 8
positive regulation of NF-kappaB transcription factor activity 0 0 -10000 0 -10000 0 0
mol:Ca2+ 0 0 -10000 0 -10000 0 0
mol:GDP -0.014 0.097 0.14 98 -0.18 107 205
CALM1 -0.012 0.042 -10000 0 -0.31 11 11
cell proliferation -0.05 0.1 -10000 0 -0.29 61 61
EIF3A -0.006 0 -10000 0 -10000 0 0
PI3K -0.018 0.12 0.17 95 -0.21 107 202
RPS6KB1 -0.02 0.06 0.39 1 -10000 0 1
mol:sphingomyelin -0.013 0.1 -10000 0 -0.88 8 8
natural killer cell activation -0.002 0.004 -10000 0 -10000 0 0
JAK3 -0.008 0.005 -10000 0 -10000 0 0
PIK3R1 -0.077 0.13 -10000 0 -0.31 131 131
JAK1 -0.009 0.019 -10000 0 -0.31 2 2
NFKB1 -0.01 0.033 -10000 0 -0.31 7 7
MYC -0.14 0.28 -10000 0 -0.92 59 59
MYB -0.071 0.27 0.53 1 -1.1 37 38
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GAB2/GRB2/SOS1/SHP2/PI3K -0.067 0.13 0.27 1 -0.34 54 55
40S S6 ribosomal protein /40s Ribosomal subunit/eIF3 -0.018 0.055 -10000 0 -10000 0 0
mol:PI-3-4-5-P3 -0.066 0.12 0.27 1 -0.34 54 55
Rac1/GDP -0.019 0.085 0.13 76 -0.16 107 183
T cell proliferation -0.064 0.12 0.26 1 -0.34 41 42
SHC1 -0.008 0.003 -10000 0 -10000 0 0
RAC1 -0.007 0.013 -10000 0 -0.31 1 1
positive regulation of cyclin-dependent protein kinase activity -0.004 0.017 0.18 1 -0.063 37 38
PRKCZ -0.066 0.12 0.26 1 -0.35 41 42
NF kappa B1 p50/RelA -0.12 0.2 -10000 0 -0.45 127 127
IL2/IL2R beta/gamma/JAK1/LCK/JAK3/PI3K -0.033 0.098 0.49 1 -0.33 9 10
HSP90AA1 -0.006 0.013 -10000 0 -0.31 1 1
RELA -0.006 0.013 -10000 0 -0.31 1 1
IL2RA -0.005 0.026 0.24 6 -10000 0 6
IL2RB -0.008 0.021 0.24 1 -0.31 2 3
TERT -0.006 0 -10000 0 -10000 0 0
E2F1 -0.028 0.11 0.47 1 -0.43 37 38
SOS1 0.003 0.05 0.24 24 -10000 0 24
RPS6 -0.006 0 -10000 0 -10000 0 0
mol:cAMP 0.002 0.009 0.041 1 -0.12 1 2
PTPN11 -0.008 0.004 -10000 0 -10000 0 0
IL2RG -0.011 0.09 0.24 30 -0.31 30 60
actin cytoskeleton organization -0.064 0.12 0.26 1 -0.34 41 42
GRB2 -0.008 0.004 -10000 0 -10000 0 0
IL2 -0.008 0.005 -10000 0 -10000 0 0
PIK3CA 0.045 0.1 0.24 122 -10000 0 122
Rac1/GTP -0.012 0.083 0.23 1 -0.15 107 108
LCK -0.008 0.006 -10000 0 -10000 0 0
BCL2 -0.17 0.3 -10000 0 -0.8 96 96
Paxillin-dependent events mediated by a4b1

Figure S50.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S50.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CRKL -0.006 0 -10000 0 -10000 0 0
Rac1/GDP 0.005 0.014 -10000 0 -0.3 1 1
DOCK1 -0.006 0.021 0.24 1 -0.31 2 3
ITGA4 0.007 0.055 0.24 30 -10000 0 30
RAC1 -0.006 0.013 -10000 0 -0.31 1 1
alpha4/beta7 Integrin 0.002 0.043 0.18 30 -0.21 1 31
mol:GTP 0 0 -10000 0 -10000 0 0
CRK -0.005 0.01 0.24 1 -10000 0 1
alpha4/beta1 Integrin 0.017 0.034 0.16 32 -10000 0 32
alpha4/beta7 Integrin/Paxillin -0.003 0.041 0.16 29 -0.16 7 36
lamellipodium assembly -0.053 0.14 -10000 0 -0.3 130 130
PIK3CA 0.047 0.1 0.24 122 -10000 0 122
PI3K -0.015 0.12 0.17 98 -0.21 107 205
ARF6 -0.006 0.013 -10000 0 -0.31 1 1
TLN1 -0.006 0.013 -10000 0 -0.31 1 1
PXN -0.009 0.023 -10000 0 -0.21 7 7
PIK3R1 -0.075 0.13 -10000 0 -0.31 131 131
ARF6/GTP -0.006 0.036 0.12 34 -0.14 7 41
cell adhesion -0.003 0.043 0.15 33 -0.29 1 34
CRKL/CBL -0.007 0 -10000 0 -10000 0 0
alpha4/beta1 Integrin/Paxillin -0.001 0.044 0.16 33 -0.16 6 39
ITGB1 -0.003 0.025 0.24 6 -10000 0 6
ITGB7 -0.006 0.016 0.24 1 -0.31 1 2
ARF6/GDP 0.005 0.014 -10000 0 -0.3 1 1
alpha4/beta1 Integrin/Paxillin/VCAM1 0.001 0.095 0.17 103 -10000 0 103
p130Cas/Crk/Dock1 0.008 0.016 0.16 2 -0.18 3 5
VCAM1 -0.01 0.14 0.24 83 -0.31 76 159
alpha4/beta1 Integrin/Paxillin/Talin -0.003 0.044 0.16 33 -0.29 1 34
alpha4/beta1 Integrin/Paxillin/GIT1 -0.003 0.043 0.16 34 -10000 0 34
BCAR1 -0.006 0.013 -10000 0 -0.31 1 1
mol:GDP 0.003 0.042 -10000 0 -0.15 34 34
CBL -0.006 0 -10000 0 -10000 0 0
PRKACA -0.006 0 -10000 0 -10000 0 0
GIT1 -0.005 0.01 0.24 1 -10000 0 1
alpha4/beta1 Integrin/Paxillin/Talin/Actin Cytoskeleton -0.003 0.044 0.16 33 -0.29 1 34
Rac1/GTP -0.059 0.15 -10000 0 -0.32 130 130
Insulin-mediated glucose transport

Figure S51.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S51.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Insulin responsive Vesicles -0.09 0.087 0.21 3 -0.24 9 12
CaM/Ca2+ -0.007 0.028 -10000 0 -0.21 11 11
AKT1 -0.005 0.01 0.24 1 -10000 0 1
AKT2 -0.004 0.023 0.24 5 -10000 0 5
STXBP4 -0.005 0.015 0.24 2 -10000 0 2
mol:GTP 0 0 -10000 0 -10000 0 0
mol:glucose -0.034 0.063 -10000 0 -10000 0 0
YWHAZ -0.006 0 -10000 0 -10000 0 0
CALM1 -0.012 0.042 -10000 0 -0.31 11 11
YWHAQ -0.006 0 -10000 0 -10000 0 0
TBC1D4 -0.006 0.012 0.2 2 -10000 0 2
mol:Ca2+ 0 0 -10000 0 -10000 0 0
YWHAH -0.007 0.022 -10000 0 -0.31 3 3
YWHAB -0.005 0.01 0.24 1 -10000 0 1
SNARE/Synip -0.13 0.082 -10000 0 -0.18 417 417
YWHAG -0.006 0 -10000 0 -10000 0 0
ASIP -0.007 0.024 0.24 1 -0.31 3 4
PRKCI 0.1 0.12 0.24 255 -10000 0 255
AS160/CaM/Ca2+ -0.007 0.028 -10000 0 -0.21 11 11
RHOQ -0.004 0.018 0.24 3 -10000 0 3
GYS1 -0.003 0.013 -10000 0 -10000 0 0
PRKCZ -0.006 0 -10000 0 -10000 0 0
TRIP10 -0.006 0 -10000 0 -10000 0 0
TC10/GTP/CIP4/Exocyst 0.007 0.011 0.15 3 -10000 0 3
AS160/14-3-3 -0.001 0.024 -10000 0 -10000 0 0
VAMP2 -0.23 0.13 -10000 0 -0.31 419 419
SLC2A4 -0.037 0.067 -10000 0 -10000 0 0
STX4 -0.006 0 -10000 0 -10000 0 0
GSK3B -0.001 0.016 0.16 6 -10000 0 6
SFN 0.003 0.047 0.24 21 -10000 0 21
LNPEP 0.001 0.045 0.24 18 -0.31 1 19
YWHAE -0.006 0.013 -10000 0 -0.31 1 1
Aurora C signaling

Figure S52.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S52.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
INCENP -0.005 0.015 0.24 2 -10000 0 2
Aurora C/Aurora B/INCENP 0.038 0.058 0.15 120 -10000 0 120
metaphase 0 0 -10000 0 -10000 0 0
mitosis 0 0 -10000 0 -10000 0 0
H3F3B -0.006 0.046 -10000 0 -0.41 7 7
AURKB 0.046 0.1 0.24 119 -10000 0 119
AURKC -0.006 0 -10000 0 -10000 0 0
Paxillin-independent events mediated by a4b1 and a4b7

Figure S53.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S53.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PTK2 0.011 0.052 0.18 30 -0.18 1 31
CRKL -0.006 0 -10000 0 -10000 0 0
Rac1/GDP -0.004 0.009 -10000 0 -0.21 1 1
DOCK1 -0.006 0.021 0.24 1 -0.31 2 3
ITGA4 0.007 0.055 0.24 30 -10000 0 30
alpha4/beta7 Integrin/MAdCAM1 0.018 0.035 0.16 30 -0.16 3 33
EPO -0.006 0 -10000 0 -10000 0 0
alpha4/beta7 Integrin 0.002 0.043 0.18 30 -0.21 1 31
mol:GTP 0 0 -10000 0 -10000 0 0
CRK -0.005 0.01 0.24 1 -10000 0 1
alpha4/beta1 Integrin 0.004 0.046 0.18 34 -10000 0 34
EPO/EPOR (dimer) -0.007 0.007 0.17 1 -10000 0 1
lamellipodium assembly -0.025 0.1 -10000 0 -0.21 99 99
PIK3CA 0.047 0.1 0.24 122 -10000 0 122
PI3K -0.015 0.12 0.17 98 -0.21 107 205
ARF6 -0.006 0.013 -10000 0 -0.31 1 1
JAK2 0.002 0.036 0.24 3 -0.26 2 5
PXN -0.01 0.033 -10000 0 -0.31 7 7
PIK3R1 -0.075 0.13 -10000 0 -0.31 131 131
MADCAM1 -0.006 0 -10000 0 -10000 0 0
cell adhesion 0.017 0.034 0.15 30 -0.16 3 33
CRKL/CBL -0.007 0 -10000 0 -10000 0 0
ITGB1 -0.003 0.025 0.24 6 -10000 0 6
SRC -0.001 0.09 0.28 14 -0.16 76 90
ITGB7 -0.006 0.016 0.24 1 -0.31 1 2
RAC1 -0.006 0.013 -10000 0 -0.31 1 1
alpha4/beta1 Integrin/VCAM1 0.007 0.09 0.16 90 -0.18 76 166
p130Cas/Crk/Dock1 -0.007 0.077 0.22 13 -10000 0 13
VCAM1 -0.01 0.14 0.24 83 -0.31 76 159
RHOA -0.007 0.018 -10000 0 -0.31 2 2
alpha4/beta1 Integrin/Paxillin/GIT1 0.018 0.041 0.29 2 -0.16 6 8
BCAR1 -0.003 0.085 0.26 14 -0.15 1 15
EPOR -0.005 0.01 0.24 1 -10000 0 1
mol:GDP 0 0 -10000 0 -10000 0 0
CBL -0.006 0 -10000 0 -10000 0 0
GIT1 -0.005 0.01 0.24 1 -10000 0 1
Rac1/GTP -0.026 0.11 -10000 0 -0.21 99 99
Regulation of Telomerase

Figure S54.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S54.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Telomerase catalytic core complex -0.13 0.19 0.47 1 -0.5 49 50
RAD9A -0.006 0 -10000 0 -10000 0 0
AP1 -0.024 0.086 0.19 32 -0.22 66 98
IFNAR2 -0.009 0.012 0.22 1 -10000 0 1
AKT1 -0.029 0.049 0.16 1 -0.17 19 20
ER alpha/Oestrogen -0.033 0.069 -10000 0 -0.21 75 75
NFX1/SIN3/HDAC complex -0.001 0.039 0.21 2 -10000 0 2
EGF -0.005 0.027 0.24 7 -10000 0 7
SMG5 -0.004 0.018 0.24 3 -10000 0 3
SMG6 -0.006 0 -10000 0 -10000 0 0
SP3/HDAC2 -0.01 0.026 0.16 9 -0.23 1 10
TERT/c-Abl -0.12 0.18 -10000 0 -0.43 115 115
SAP18 -0.007 0.013 -10000 0 -0.31 1 1
MRN complex 0.034 0.057 0.16 99 -0.18 2 101
WT1 -0.027 0.07 -10000 0 -0.31 32 32
WRN 0.012 0.063 0.24 40 -10000 0 40
SP1 -0.012 0.01 -10000 0 -10000 0 0
SP3 -0.008 0.005 -10000 0 -10000 0 0
TERF2IP -0.006 0 -10000 0 -10000 0 0
Telomerase/Nucleolin -0.12 0.18 -10000 0 -0.43 96 96
Mad/Max -0.01 0.014 0.16 3 -10000 0 3
TERT -0.13 0.2 0.47 1 -0.52 43 44
CCND1 -0.27 0.44 0.58 1 -1 150 151
MAX -0.008 0.005 -10000 0 -10000 0 0
RBBP7 -0.008 0.018 -10000 0 -0.31 2 2
RBBP4 0.001 0.043 0.24 18 -10000 0 18
TERF2 -0.008 0.001 -10000 0 -10000 0 0
PTGES3 -0.055 0.11 -10000 0 -0.31 93 93
SIN3A -0.007 0.002 -10000 0 -10000 0 0
Telomerase/911 -0.02 0.085 0.24 2 -10000 0 2
CDKN1B -0.002 0.071 0.36 12 -0.37 3 15
RAD1 0.004 0.049 0.24 23 -10000 0 23
XRCC5 0.008 0.056 0.24 31 -10000 0 31
XRCC6 -0.006 0 -10000 0 -10000 0 0
SAP30 -0.007 0.002 -10000 0 -10000 0 0
TRF2/PARP2 0.01 0.053 0.16 60 -10000 0 60
UBE3A -0.008 0.004 -10000 0 -10000 0 0
JUN -0.003 0.043 0.24 14 -0.31 2 16
E6 -0.002 0.004 -10000 0 -10000 0 0
HPV-16 E6/E6AP -0.007 0.006 -10000 0 -10000 0 0
FOS -0.031 0.11 0.24 26 -0.31 65 91
IFN-gamma/IRF1 -0.005 0.06 0.2 32 -0.22 10 42
PARP2 0.021 0.077 0.24 62 -10000 0 62
BLM 0.084 0.12 0.24 206 -10000 0 206
Telomerase -0.016 0.07 0.22 1 -0.32 2 3
IRF1 -0.007 0.056 0.21 19 -0.28 10 29
ESR1 -0.047 0.1 -10000 0 -0.31 75 75
KU/TER 0.003 0.04 0.17 31 -10000 0 31
ATM/TRF2 -0.002 0.029 0.16 18 -10000 0 18
ubiquitin-dependent protein catabolic process -0.001 0.039 0.21 2 -10000 0 2
HPV-16 E6/E6AP/NFX1/SIN3/HDAC complex -0.002 0.04 0.21 2 -10000 0 2
HDAC1 0.009 0.06 0.24 36 -10000 0 36
HDAC2 -0.007 0.038 0.24 11 -0.32 1 12
ATM 0.008 0.036 0.21 18 -10000 0 18
SMAD3 -0.036 0.077 -10000 0 -0.21 91 91
ABL1 -0.008 0.028 -10000 0 -0.31 5 5
MXD1 -0.007 0.021 0.24 4 -10000 0 4
MRE11A 0.025 0.081 0.24 70 -10000 0 70
HUS1 -0.006 0 -10000 0 -10000 0 0
RPS6KB1 -0.001 0.033 0.24 10 -10000 0 10
TERT/NF kappa B1/14-3-3 -0.12 0.18 -10000 0 -0.42 109 109
NR2F2 -0.004 0.039 -10000 0 -0.3 9 9
MAPK3 -0.016 0.032 -10000 0 -0.22 14 14
MAPK1 -0.011 0.013 0.18 1 -0.21 1 2
TGFB1/TGF beta receptor Type II -0.05 0.11 -10000 0 -0.31 90 90
NFKB1 -0.01 0.033 -10000 0 -0.31 7 7
HNRNPC -0.006 0 -10000 0 -10000 0 0
DNA damage response signal transduction by p53 class mediator resulting in induction of apoptosis 0.008 0.036 0.21 18 -10000 0 18
NBN 0.015 0.071 0.24 49 -0.31 1 50
EGFR -0.032 0.084 0.24 1 -0.31 46 47
mol:Oestrogen -0.001 0.003 -10000 0 -10000 0 0
EGF/EGFR -0.025 0.06 0.16 6 -0.22 46 52
MYC -0.039 0.092 -10000 0 -0.31 59 59
IL2 -0.012 0.011 -10000 0 -10000 0 0
KU 0.003 0.04 0.17 31 -10000 0 31
RAD50 -0.005 0.019 0.24 2 -0.31 1 3
HSP90AA1 -0.006 0.013 -10000 0 -0.31 1 1
TGFB1 -0.05 0.11 -10000 0 -0.31 90 90
TRF2/BLM 0.051 0.081 0.16 196 -10000 0 196
FRAP1 -0.006 0 -10000 0 -10000 0 0
KU/TERT -0.12 0.19 -10000 0 -0.43 106 106
SP1/HDAC2 -0.013 0.027 0.17 7 -0.24 1 8
PINX1 -0.002 0.029 0.24 8 -10000 0 8
Telomerase/EST1A -0.12 0.18 -10000 0 -0.42 107 107
Smad3/Myc -0.048 0.087 -10000 0 -0.2 131 131
911 complex 0.015 0.029 0.16 23 -10000 0 23
IFNG 0.002 0.055 0.23 30 -0.2 1 31
Telomerase/PinX1 -0.12 0.18 -10000 0 -0.42 106 106
Telomerase/AKT1/mTOR/p70S6K -0.062 0.12 -10000 0 -0.37 30 30
SIN3B -0.006 0.011 0.24 1 -10000 0 1
YWHAE -0.006 0.013 -10000 0 -0.31 1 1
Telomerase/EST1B -0.12 0.18 -10000 0 -0.42 105 105
response to DNA damage stimulus 0.004 0.018 -10000 0 -10000 0 0
MRN complex/TRF2/Rap1 0.014 0.062 0.27 7 -10000 0 7
TRF2/WRN 0.002 0.041 0.16 35 -10000 0 35
Telomerase/hnRNP C1/C2 -0.12 0.18 -10000 0 -0.42 106 106
E2F1 -0.01 0.007 -10000 0 -10000 0 0
ZNFX1 -0.004 0.025 0.24 6 -10000 0 6
PIF1 -0.006 0 -10000 0 -10000 0 0
NCL -0.005 0.01 0.24 1 -10000 0 1
DKC1 0.036 0.092 0.24 95 -10000 0 95
telomeric DNA binding 0 0 -10000 0 -10000 0 0
Signaling events mediated by PTP1B

Figure S55.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S55.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PDGFRB -0.01 0.033 -10000 0 -0.31 7 7
Jak2/Leptin Receptor 0.002 0.063 0.22 2 -0.4 3 5
PTP1B/AKT1 -0.012 0.077 -10000 0 -0.22 20 20
FYN -0.047 0.1 0.24 1 -0.31 79 80
p210 bcr-abl/PTP1B -0.008 0.085 -10000 0 -0.24 20 20
EGFR -0.027 0.086 0.24 1 -0.32 46 47
EGF/EGFR -0.036 0.075 0.21 3 -0.27 29 32
CSF1 -0.018 0.06 0.24 1 -0.31 23 24
AKT1 -0.006 0.011 0.24 1 -10000 0 1
INSR -0.034 0.089 -10000 0 -0.31 53 53
PTP1B/N-cadherin 0.008 0.11 0.22 30 -0.26 35 65
Insulin Receptor/Insulin -0.024 0.077 -10000 0 -0.26 21 21
HCK -0.005 0.01 0.24 1 -10000 0 1
CRK -0.005 0.01 0.24 1 -10000 0 1
TYK2 -0.01 0.081 -10000 0 -0.23 20 20
EGF 0 0.028 0.24 7 -10000 0 7
YES1 0.006 0.052 0.24 26 -10000 0 26
CAV1 -0.036 0.1 -10000 0 -0.31 35 35
TXN -0.014 0.058 -10000 0 -0.31 20 20
PTP1B/IRS1/GRB2 -0.094 0.1 -10000 0 -0.28 70 70
cell migration 0.008 0.085 0.24 20 -10000 0 20
STAT3 -0.011 0.04 -10000 0 -0.31 10 10
PRLR 0.003 0.046 0.24 20 -10000 0 20
ITGA2B -0.006 0.003 -10000 0 -10000 0 0
CSF1R -0.006 0.03 0.24 4 -0.31 3 7
Prolactin Receptor/Prolactin 0 0.035 0.17 22 -10000 0 22
FGR -0.006 0 -10000 0 -10000 0 0
PTP1B/p130 Cas -0.01 0.081 -10000 0 -0.23 20 20
Crk/p130 Cas -0.01 0.08 -10000 0 -0.23 20 20
DOK1 -0.017 0.081 -10000 0 -0.28 10 10
JAK2 0 0.061 -10000 0 -0.46 2 2
Jak2/Leptin Receptor/Leptin -0.022 0.071 0.17 2 -0.33 5 7
PIK3R1 -0.075 0.13 -10000 0 -0.31 131 131
PTPN1 -0.009 0.086 -10000 0 -0.24 20 20
LYN -0.014 0.048 -10000 0 -0.31 15 15
CDH2 -0.003 0.15 0.24 101 -0.31 77 178
SRC 0.001 0.036 -10000 0 -10000 0 0
ITGB3 -0.041 0.11 0.24 12 -0.31 77 89
CAT1/PTP1B -0.024 0.092 -10000 0 -0.26 26 26
CAPN1 -0.006 0.019 -10000 0 -0.31 2 2
CSK -0.006 0 -10000 0 -10000 0 0
PI3K -0.045 0.094 0.14 1 -0.25 48 49
mol:H2O2 0 0.003 -10000 0 -10000 0 0
STAT3 (dimer) -0.021 0.067 0.22 1 -0.36 4 5
negative regulation of transcription 0 0.06 -10000 0 -0.46 2 2
FCGR2A -0.007 0.045 0.24 7 -0.31 8 15
FER -0.002 0.012 0.24 1 -10000 0 1
alphaIIb/beta3 Integrin -0.027 0.078 0.17 12 -0.22 77 89
BLK -0.005 0.01 0.24 1 -10000 0 1
Insulin Receptor/Insulin/Shc -0.013 0.054 -10000 0 -0.18 53 53
RHOA -0.006 0.019 -10000 0 -0.31 2 2
LEPR -0.004 0.026 0.24 5 -0.31 1 6
BCAR1 -0.006 0.013 -10000 0 -0.31 1 1
p210 bcr-abl/Grb2 -0.006 0 -10000 0 -10000 0 0
mol:NADPH 0 0.002 -10000 0 -10000 0 0
TRPV6 -0.026 0.076 -10000 0 -0.22 23 23
PRL -0.005 0.011 0.24 1 -10000 0 1
SOCS3 -0.002 0.075 0.53 2 -1.1 2 4
SPRY2 -0.028 0.12 0.24 40 -0.31 72 112
Insulin Receptor/Insulin/IRS1 -0.13 0.1 -10000 0 -0.2 368 368
CSF1/CSF1R -0.015 0.089 0.27 1 -0.24 27 28
Ras protein signal transduction -0.003 0.027 -10000 0 -10000 0 0
IRS1 -0.2 0.15 -10000 0 -0.31 357 357
INS -0.006 0.003 -10000 0 -10000 0 0
LEP -0.005 0.003 -10000 0 -10000 0 0
STAT5B -0.007 0.078 -10000 0 -0.26 12 12
STAT5A -0.006 0.074 -10000 0 -0.22 10 10
GRB2 -0.006 0 -10000 0 -10000 0 0
PDGFB-D/PDGFRB -0.011 0.082 -10000 0 -0.24 21 21
CSN2 0.003 0.034 0.51 1 -10000 0 1
PIK3CA 0.047 0.1 0.24 122 -10000 0 122
LAT -0.004 0.07 -10000 0 -0.48 8 8
YBX1 -0.008 0.003 -10000 0 -10000 0 0
LCK -0.006 0 -10000 0 -10000 0 0
SHC1 -0.006 0 -10000 0 -10000 0 0
NOX4 0.082 0.12 0.24 202 -10000 0 202
RXR and RAR heterodimerization with other nuclear receptor

Figure S56.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S56.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TGFB1 -0.16 0.36 -10000 0 -0.99 90 90
VDR -0.005 0.01 0.24 1 -10000 0 1
FAM120B -0.007 0.022 -10000 0 -0.31 3 3
RXRs/LXRs/DNA/9cRA 0.014 0.093 0.32 36 -0.35 1 37
RXRs/LXRs/DNA/Oxysterols 0.018 0.11 0.4 36 -0.45 2 38
MED1 -0.005 0.015 0.24 2 -10000 0 2
mol:9cRA 0.007 0.021 0.1 2 -10000 0 2
RARs/THRs/DNA/Src-1 -0.038 0.087 0.21 1 -0.19 127 128
RXRs/NUR77 -0.049 0.1 0.27 4 -0.29 6 10
RXRs/PPAR 0.007 0.047 0.23 2 -0.19 10 12
NCOR2 -0.011 0.038 -10000 0 -0.31 9 9
VDR/VDR/Vit D3 -0.003 0.007 0.17 1 -10000 0 1
RARs/VDR/DNA/Vit D3 0.016 0.027 -10000 0 -10000 0 0
RARA -0.006 0 -10000 0 -10000 0 0
NCOA1 -0.007 0.018 -10000 0 -0.31 2 2
VDR/VDR/DNA -0.005 0.01 0.24 1 -10000 0 1
RARs/RARs/DNA/9cRA 0.018 0.029 0.14 24 -10000 0 24
RARG -0.001 0.034 0.24 11 -10000 0 11
RPS6KB1 -0.062 0.15 0.35 9 -0.4 89 98
RARs/THRs/DNA/SMRT -0.041 0.091 0.21 1 -0.19 132 133
THRA -0.079 0.13 -10000 0 -0.31 138 138
mol:Bile acids 0 0 -10000 0 -10000 0 0
VDR/Vit D3/DNA -0.003 0.007 0.17 1 -10000 0 1
RXRs/PPAR/9cRA/PGJ2/DNA 0.044 0.11 0.3 41 -10000 0 41
NR1H4 -0.004 0.023 0.24 5 -10000 0 5
RXRs/LXRs/DNA 0.017 0.094 0.31 36 -0.27 1 37
NR1H2 -0.01 0.057 -10000 0 -0.31 17 17
NR1H3 -0.001 0.024 -10000 0 -10000 0 0
RXRs/VDR/DNA/Vit D3 0.018 0.067 0.24 6 -10000 0 6
NR4A1 -0.12 0.15 0.24 4 -0.31 228 232
mol:ATRA 0 0 -10000 0 -10000 0 0
RXRs/FXR/9cRA/MED1 0.012 0.051 0.22 2 -10000 0 2
RXRG 0.009 0.047 0.24 15 -0.31 1 16
RXR alpha/CCPG -0.005 0.04 -10000 0 -0.2 18 18
RXRA -0.004 0.054 -10000 0 -0.3 15 15
RXRB 0.004 0.025 -10000 0 -10000 0 0
THRB 0.006 0.053 0.24 27 -10000 0 27
PPARG -0.004 0.023 0.24 5 -10000 0 5
PPARD -0.006 0 -10000 0 -10000 0 0
TNF 0.017 0.1 0.47 2 -10000 0 2
mol:Oxysterols 0.004 0.019 -10000 0 -10000 0 0
cholesterol transport 0.018 0.11 0.39 36 -0.44 2 38
PPARA -0.006 0 -10000 0 -10000 0 0
mol:Vit D3 0 0 -10000 0 -10000 0 0
RARB 0 0.037 0.24 13 -10000 0 13
RXRs/NUR77/BCL2 -0.1 0.12 0.19 2 -0.22 262 264
SREBF1 0.013 0.12 0.44 1 -0.86 4 5
RXRs/RXRs/DNA/9cRA 0.043 0.11 0.3 41 -10000 0 41
ABCA1 0.027 0.14 0.51 35 -0.46 1 36
RARs/THRs -0.016 0.081 0.28 1 -0.15 127 128
RXRs/FXR 0.02 0.073 0.25 7 -10000 0 7
BCL2 -0.055 0.11 0.24 1 -0.31 93 94
Fc-epsilon receptor I signaling in mast cells

Figure S57.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S57.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PPAP2A -0.005 0.01 0.24 1 -10000 0 1
LAT2 -0.008 0.074 -10000 0 -0.26 30 30
AP1 -0.016 0.091 0.26 5 -0.34 19 24
mol:PIP3 -0.012 0.085 0.17 5 -0.3 30 35
IKBKB -0.006 0.054 0.13 5 -0.19 22 27
AKT1 -0.031 0.099 0.19 19 -0.25 31 50
IKBKG -0.006 0.054 0.12 17 -0.18 28 45
MS4A2 -0.003 0.008 -10000 0 -10000 0 0
mol:Sphingosine-1-phosphate 0 0 -10000 0 -10000 0 0
PIK3CA 0.047 0.1 0.24 122 -10000 0 122
MAP3K1 -0.009 0.078 0.18 5 -0.29 20 25
mol:Ca2+ -0.008 0.07 0.16 5 -0.24 28 33
LYN -0.013 0.051 -10000 0 -0.32 15 15
CBLB -0.007 0.074 0.19 1 -0.26 30 31
SHC1 -0.006 0 -10000 0 -10000 0 0
RasGAP/p62DOK -0.026 0.069 0.15 3 -0.16 119 122
positive regulation of cell migration -0.006 0.021 -10000 0 -0.21 6 6
INPP5D 0 0 -10000 0 -10000 0 0
PLD2 -0.022 0.07 0.11 2 -0.15 85 87
PTPN13 -0.02 0.11 0.3 2 -0.4 17 19
PTPN11 -0.005 0.006 -10000 0 -10000 0 0
GO:0007205 0 0 -10000 0 -10000 0 0
regulation of mast cell degranulation -0.017 0.09 0.18 29 -0.23 21 50
SYK -0.007 0.035 0.24 2 -0.32 6 8
GRB2 -0.005 0.003 -10000 0 -10000 0 0
LAT/PLCgamma1/GRB2/SLP76/GADs -0.03 0.069 -10000 0 -0.29 32 32
LAT -0.008 0.073 -10000 0 -0.26 30 30
PAK2 -0.008 0.084 0.17 17 -0.29 26 43
NFATC2 -0.022 0.082 -10000 0 -0.42 23 23
HRAS -0.007 0.088 0.18 17 -0.31 26 43
GAB2 -0.006 0.061 0.24 15 -0.31 13 28
PLA2G1B -0.018 0.038 -10000 0 -10000 0 0
Fc epsilon R1 0.005 0.066 0.15 72 -0.16 31 103
Antigen/IgE/Fc epsilon R1 0.006 0.061 0.14 72 -0.14 30 102
mol:GDP -0.007 0.093 0.2 18 -0.32 27 45
JUN -0.001 0.042 0.24 14 -0.31 2 16
mol:Ca++ 0 0 -10000 0 -10000 0 0
PIK3R1 -0.073 0.13 -10000 0 -0.31 131 131
FOS -0.029 0.11 0.24 26 -0.31 65 91
Antigen/IgE/Fc epsilon R1/LYN/SYK -0.006 0.077 -10000 0 -0.27 30 30
CHUK -0.003 0.056 0.15 8 -0.19 21 29
KLRG1 -0.005 0.066 -10000 0 -0.24 23 23
VAV1 -0.008 0.075 0.2 1 -0.26 30 31
calcium-dependent protein kinase C activity 0 0 -10000 0 -10000 0 0
CBL -0.008 0.073 -10000 0 -0.26 30 30
negative regulation of mast cell degranulation -0.006 0.061 -10000 0 -0.22 23 23
BTK -0.008 0.092 0.22 19 -0.32 27 46
Fc epsilon R1/FcgammaRIIB/SHIP/RasGAP/p62DOK 0.004 0.068 0.2 29 -0.32 1 30
GAB2/PI3K/SHP2 -0.056 0.075 -10000 0 -0.17 149 149
Antigen/IgE/Fc epsilon R1/LYN/SYK/WIP -0.006 0.076 -10000 0 -0.26 29 29
RAF1 0.002 0.012 -10000 0 -10000 0 0
Fc epsilon R1/FcgammaRIIB/SHIP 0.022 0.077 0.19 70 -0.14 28 98
FCER1G 0.007 0.11 0.23 69 -0.31 31 100
FCER1A -0.003 0.018 0.24 3 -10000 0 3
Antigen/IgE/Fc epsilon R1/Fyn -0.016 0.08 0.14 68 -0.16 97 165
MAPK3 -0.018 0.042 -10000 0 -10000 0 0
MAPK1 -0.015 0.033 -10000 0 -10000 0 0
NFKB1 -0.01 0.033 -10000 0 -0.31 7 7
MAPK8 0.003 0.052 -10000 0 -0.4 6 6
DUSP1 -0.065 0.12 0.24 3 -0.31 114 117
NF-kappa-B/RelA -0.013 0.031 -10000 0 -0.16 16 16
actin cytoskeleton reorganization 0.002 0.087 -10000 0 -0.38 12 12
mol:Glucocorticoid Dexamethasone 0 0 -10000 0 -10000 0 0
PI3K -0.019 0.12 0.22 14 -0.32 28 42
FER -0.008 0.073 -10000 0 -0.26 30 30
RELA -0.006 0.013 -10000 0 -0.31 1 1
ITK 0.002 0.032 0.16 13 -10000 0 13
SOS1 0.005 0.05 0.24 24 -10000 0 24
PLCG1 -0.008 0.088 0.19 18 -0.3 27 45
cytokine secretion -0.011 0.022 -10000 0 -0.14 7 7
SPHK1 -0.008 0.073 -10000 0 -0.26 30 30
PTK2 0.002 0.09 -10000 0 -0.39 12 12
NTAL/PLCgamma1/GRB2/SLP76/GADs -0.029 0.071 -10000 0 -0.3 32 32
EDG1 -0.006 0.021 -10000 0 -0.21 6 6
mol:DAG -0.011 0.084 0.18 5 -0.3 28 33
MAP2K2 -0.026 0.056 -10000 0 -10000 0 0
MAP2K1 -0.001 0.012 -10000 0 -10000 0 0
MAP2K7 -0.006 0 -10000 0 -10000 0 0
KLRG1/SHP2 -0.015 0.048 -10000 0 -0.25 14 14
MAP2K4 -0.003 0.086 -10000 0 -0.84 6 6
Fc epsilon R1/FcgammaRIIB 0.024 0.083 0.2 70 -0.15 30 100
mol:Choline -0.022 0.069 0.11 2 -0.15 85 87
SHC/Grb2/SOS1 -0.003 0.076 0.23 2 -0.27 20 22
FYN -0.047 0.1 0.24 1 -0.31 79 80
DOK1 -0.007 0.018 -10000 0 -0.31 2 2
PXN -0.002 0.086 -10000 0 -0.37 12 12
HCLS1 -0.005 0.081 0.22 7 -0.27 30 37
PRKCB -0.008 0.068 0.15 5 -0.24 28 33
FCGR2B 0.008 0.06 0.24 34 -0.31 1 35
IGHE 0 0.003 -10000 0 -10000 0 0
KLRG1/SHIP -0.006 0.062 -10000 0 -0.23 23 23
LCP2 -0.014 0.053 -10000 0 -0.31 18 18
PLA2G4A -0.074 0.1 -10000 0 -0.33 34 34
RASA1 -0.007 0.022 -10000 0 -0.31 3 3
mol:Phosphatidic acid -0.022 0.069 0.11 2 -0.15 85 87
IKK complex -0.003 0.046 0.13 8 -0.15 14 22
WIPF1 -0.006 0 -10000 0 -10000 0 0
Canonical NF-kappaB pathway

Figure S58.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S58.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
FBXW11 -0.009 0.011 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
NF kappa B1 p50/RelA/I kappa B alpha 0.035 0.068 0.22 8 -0.27 1 9
ERC1 -0.005 0.024 0.24 4 -0.31 1 5
RIP2/NOD2 0.049 0.083 0.17 180 -10000 0 180
NFKBIA -0.022 0.057 -10000 0 -0.38 13 13
BIRC2 0.059 0.11 0.24 149 -10000 0 149
IKBKB -0.005 0.015 0.24 2 -10000 0 2
RIPK2 0.073 0.12 0.24 180 -10000 0 180
IKBKG 0.045 0.063 0.18 61 -10000 0 61
IKK complex/A20 0.017 0.047 0.25 3 -10000 0 3
NEMO/A20/RIP2 0.072 0.12 0.24 180 -10000 0 180
XPO1 0.014 0.068 0.24 46 -10000 0 46
NEMO/ATM 0.055 0.075 0.26 26 -10000 0 26
tumor necrosis factor receptor activity 0 0 -10000 0 -10000 0 0
RAN -0.006 0 -10000 0 -10000 0 0
Exportin 1/RanGTP 0.018 0.04 0.15 46 -10000 0 46
IKK complex/ELKS -0.002 0.016 -10000 0 -10000 0 0
BCL10/MALT1/TRAF6 0.019 0.038 0.16 40 -10000 0 40
NOD2 -0.005 0.01 0.24 1 -10000 0 1
NFKB1 -0.013 0.037 -10000 0 -0.33 7 7
RELA -0.01 0.017 -10000 0 -0.31 1 1
MALT1 0.011 0.062 0.24 38 -10000 0 38
cIAP1/UbcH5C 0.039 0.078 0.17 149 -10000 0 149
ATM 0.002 0.043 0.24 18 -10000 0 18
TNF/TNFR1A -0.013 0.038 0.17 1 -0.21 19 20
TRAF6 -0.005 0.015 0.24 2 -10000 0 2
PRKCA -0.005 0.037 0.24 7 -0.31 4 11
CHUK 0.002 0.043 0.24 18 -10000 0 18
UBE2D3 -0.006 0 -10000 0 -10000 0 0
TNF -0.005 0.01 0.24 1 -10000 0 1
NF kappa B1 p50/RelA -0.019 0.038 -10000 0 -0.22 19 19
BCL10 -0.006 0 -10000 0 -10000 0 0
proteasomal ubiquitin-dependent protein catabolic process -0.022 0.057 -10000 0 -0.38 13 13
beta TrCP1/SCF ubiquitin ligase complex -0.009 0.011 -10000 0 -10000 0 0
TNFRSF1A -0.016 0.054 -10000 0 -0.31 19 19
IKK complex 0.049 0.067 0.24 14 -10000 0 14
CYLD -0.006 0 -10000 0 -10000 0 0
IKK complex/PKC alpha 0.027 0.054 0.23 15 -10000 0 15
ceramide signaling pathway

Figure S59.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S59.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
MAP4K4 -0.048 0.11 -10000 0 -0.27 95 95
BAG4 -0.006 0 -10000 0 -10000 0 0
BAD -0.019 0.034 -10000 0 -0.15 12 12
NFKBIA -0.013 0.045 -10000 0 -0.31 13 13
BIRC3 -0.047 0.12 0.24 16 -0.31 90 106
BAX -0.019 0.034 -10000 0 -0.15 12 12
EnzymeConsortium:3.1.4.12 -0.012 0.026 -10000 0 -0.064 96 96
IKBKB -0.048 0.11 -10000 0 -0.26 94 94
MAP2K2 -0.039 0.054 -10000 0 -0.14 93 93
MAP2K1 -0.022 0.03 -10000 0 -0.16 6 6
SMPD1 -0.013 0.026 -10000 0 -0.11 12 12
GO:0005551 0 0 -10000 0 -10000 0 0
FADD/Caspase 8 -0.048 0.11 -10000 0 -0.27 96 96
MAP2K4 -0.022 0.035 -10000 0 -0.14 22 22
protein ubiquitination -0.047 0.11 -10000 0 -0.26 93 93
EnzymeConsortium:2.7.1.37 -0.031 0.039 -10000 0 -0.2 9 9
response to UV 0 0 -10000 0 -0.002 9 9
RAF1 -0.021 0.032 -10000 0 -0.15 12 12
CRADD -0.006 0 -10000 0 -10000 0 0
mol:ceramide -0.018 0.036 -10000 0 -0.14 18 18
I-kappa-B-alpha/RELA/p50/ubiquitin 0.001 0.028 -10000 0 -0.18 14 14
MADD -0.006 0 -10000 0 -10000 0 0
MAP3K1 -0.02 0.036 -10000 0 -0.15 16 16
TRADD -0.01 0.036 -10000 0 -0.31 8 8
RELA/p50 -0.006 0.013 -10000 0 -0.31 1 1
MAPK3 -0.034 0.045 -10000 0 -0.18 21 21
MAPK1 -0.031 0.042 -10000 0 -0.18 15 15
p50/RELA/I-kappa-B-alpha -0.012 0.032 -10000 0 -0.21 14 14
FADD -0.049 0.11 -10000 0 -0.27 98 98
KSR1 -0.02 0.034 -10000 0 -0.16 12 12
MAPK8 -0.021 0.033 0.1 1 -0.14 10 11
TRAF2 -0.004 0.004 -10000 0 -10000 0 0
response to radiation 0 0 -10000 0 -0.002 1 1
CHUK -0.044 0.11 -10000 0 -0.26 94 94
TNF R/SODD -0.012 0.037 -10000 0 -0.21 19 19
TNF -0.006 0.01 0.24 1 -10000 0 1
CYCS -0.005 0.047 0.12 4 -0.15 9 13
IKBKG -0.048 0.11 -10000 0 -0.26 95 95
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD -0.049 0.12 -10000 0 -0.28 98 98
RELA -0.006 0.013 -10000 0 -0.31 1 1
RIPK1 -0.004 0.004 -10000 0 -10000 0 0
AIFM1 -0.003 0.05 0.12 16 -0.15 9 25
TNF/TNF R/SODD 0 0.034 0.16 1 -0.18 19 20
TNFRSF1A -0.014 0.055 -10000 0 -0.31 19 19
response to heat 0 0 -10000 0 -0.002 1 1
CASP8 -0.009 0.047 -10000 0 -0.9 1 1
NSMAF -0.048 0.11 -10000 0 -0.27 95 95
response to hydrogen peroxide 0 0 -10000 0 -0.002 9 9
BCL2 -0.055 0.11 0.24 1 -0.31 93 94
Regulation of Androgen receptor activity

Figure S60.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S60.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
HDAC1 0.017 0.075 0.23 57 -10000 0 57
SMARCC1 -0.011 0.027 0.5 1 -10000 0 1
REL -0.006 0 -10000 0 -10000 0 0
HDAC7 -0.11 0.1 0.22 3 -0.25 139 142
JUN -0.001 0.042 0.24 14 -0.31 2 16
EP300 -0.007 0.018 -10000 0 -0.31 2 2
KAT2B 0 0 -10000 0 -10000 0 0
KAT5 0 0 -10000 0 -10000 0 0
MAPK14 0.009 0.075 0.19 83 -10000 0 83
FOXO1 -0.009 0.031 -10000 0 -0.31 6 6
T-DHT/AR -0.11 0.11 0.24 3 -0.26 139 142
MAP2K6 0.021 0.089 0.24 82 -10000 0 82
BRM/BAF57 -0.056 0.087 -10000 0 -0.21 136 136
MAP2K4 -0.018 0.032 -10000 0 -0.31 6 6
SMARCA2 -0.078 0.13 -10000 0 -0.31 136 136
PDE9A -0.16 0.28 -10000 0 -1 51 51
NCOA2 -0.005 0.015 0.24 2 -10000 0 2
CEBPA -0.006 0 -10000 0 -10000 0 0
EHMT2 -0.006 0 -10000 0 -10000 0 0
cell proliferation -0.14 0.12 -10000 0 -0.32 83 83
NR0B1 0.002 0.044 0.24 19 -10000 0 19
EGR1 -0.12 0.15 0.24 3 -0.31 212 215
RXRs/9cRA 0.007 0.034 0.15 13 -0.16 15 28
AR/RACK1/Src -0.063 0.064 0.16 1 -0.26 4 5
AR/GR -0.12 0.1 0.15 1 -0.22 280 281
GNB2L1 -0.006 0 -10000 0 -10000 0 0
PKN1 -0.004 0.028 0.24 6 -0.31 1 7
RCHY1 0.004 0.048 0.24 22 -10000 0 22
epidermal growth factor receptor activity 0 0 -10000 0 -10000 0 0
MAPK8 -0.02 0.032 0.18 6 -0.22 6 12
T-DHT/AR/TIF2/CARM1 -0.063 0.069 0.21 2 -0.27 3 5
SRC -0.02 0.06 0.24 3 -0.2 2 5
NR3C1 -0.011 0.04 -10000 0 -0.31 10 10
KLK3 -0.05 0.062 -10000 0 -10000 0 0
APPBP2 -0.013 0.028 0.24 5 -0.31 1 6
TRIM24 -0.004 0.023 0.24 5 -10000 0 5
T-DHT/AR/TIP60 -0.063 0.069 0.19 3 -0.2 15 18
TMPRSS2 -0.42 0.46 -10000 0 -0.94 245 245
RXRG 0 0.044 0.24 15 -0.31 2 17
mol:9cRA 0 0 -10000 0 -10000 0 0
RXRA -0.014 0.048 -10000 0 -0.31 15 15
RXRB -0.006 0 -10000 0 -10000 0 0
CARM1 -0.005 0.01 0.24 1 -10000 0 1
NR2C2 -0.006 0 -10000 0 -10000 0 0
KLK2 -0.053 0.057 -10000 0 -10000 0 0
AR -0.12 0.12 0.18 2 -0.24 278 280
SENP1 0.006 0.054 0.24 28 -10000 0 28
HSP90AA1 -0.006 0.013 -10000 0 -0.31 1 1
MDM2 -0.006 0.023 0.24 2 -0.31 2 4
SRY -0.006 0 -10000 0 -10000 0 0
GATA2 -0.009 0.035 0.24 1 -0.31 7 8
MYST2 -0.006 0.013 -10000 0 -0.31 1 1
HOXB13 -0.005 0.01 0.24 1 -10000 0 1
T-DHT/AR/RACK1/Src -0.064 0.068 0.19 3 -0.26 4 7
positive regulation of transcription -0.009 0.035 0.24 1 -0.31 7 8
DNAJA1 -0.014 0.024 0.23 3 -0.32 1 4
proteasomal ubiquitin-dependent protein catabolic process 0.017 0.056 0.27 10 -0.27 2 12
NCOA1 0.004 0.023 0.17 1 -0.34 2 3
SPDEF -0.022 0.07 0.24 1 -0.31 32 33
T-DHT/AR/TIF2 -0.051 0.055 -10000 0 -0.25 9 9
T-DHT/AR/Hsp90 -0.064 0.071 0.2 3 -0.27 5 8
GSK3B -0.005 0.008 -10000 0 -10000 0 0
NR2C1 -0.005 0.015 0.24 2 -10000 0 2
mol:T-DHT -0.019 0.066 0.2 6 -0.19 5 11
SIRT1 -0.006 0 -10000 0 -10000 0 0
ZMIZ2 -0.006 0 -10000 0 -10000 0 0
POU2F1 -0.051 0.05 -10000 0 -10000 0 0
T-DHT/AR/DAX-1 -0.059 0.077 0.21 7 -0.27 4 11
CREBBP -0.012 0.042 -10000 0 -0.31 11 11
SMARCE1 -0.006 0 -10000 0 -10000 0 0
IL6-mediated signaling events

Figure S61.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S61.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BCL2L1 -0.18 0.28 -10000 0 -0.8 60 60
CRP -0.18 0.28 -10000 0 -0.8 60 60
cell cycle arrest -0.21 0.34 -10000 0 -0.97 63 63
TIMP1 -0.19 0.3 -10000 0 -0.77 89 89
IL6ST -0.019 0.05 -10000 0 -0.31 15 15
Rac1/GDP -0.054 0.096 0.36 1 -0.4 11 12
AP1 -0.023 0.12 0.65 1 -0.51 14 15
GAB2 -0.005 0.061 0.24 15 -0.31 13 28
TNFSF11 -0.18 0.28 -10000 0 -0.8 60 60
HSP90B1 -0.033 0.093 -10000 0 -0.97 4 4
GAB1 -0.006 0.019 -10000 0 -0.31 2 2
MAPK14 -0.008 0.078 0.47 1 -0.46 5 6
AKT1 -0.016 0.088 0.58 1 -0.37 1 2
FOXO1 -0.021 0.086 0.54 1 -0.36 1 2
MAP2K6 -0.016 0.082 0.44 1 -0.42 5 6
mol:GTP -0.002 0.003 -10000 0 -10000 0 0
MAP2K4 -0.086 0.14 0.44 1 -0.49 11 12
MITF -0.043 0.083 0.35 1 -0.34 16 17
positive regulation of NF-kappaB transcription factor activity 0 0 -10000 0 -10000 0 0
TYK2 -0.006 0 -10000 0 -10000 0 0
A2M -0.057 0.26 0.52 3 -1.2 28 31
CEBPB -0.007 0.028 0.24 1 -0.31 4 5
GRB2/SOS1/GAB family/SHP2 -0.011 0.085 0.27 1 -0.38 14 15
STAT3 -0.23 0.37 -10000 0 -1 71 71
STAT1 0.11 0.11 0.28 9 -10000 0 9
CEBPD -0.23 0.37 -10000 0 -1 84 84
PIK3CA 0.047 0.1 0.24 122 -10000 0 122
PI3K -0.014 0.12 0.17 98 -0.21 107 205
JUN -0.001 0.042 0.24 14 -0.31 2 16
PIAS3/MITF -0.043 0.08 0.32 1 -0.36 10 11
MAPK11 -0.009 0.077 0.47 1 -0.46 5 6
STAT3 (dimer)/FOXO1 -0.18 0.26 -10000 0 -0.7 72 72
GRB2/SOS1/GAB family -0.019 0.074 0.22 6 -0.28 10 16
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/HCK -0.025 0.064 0.25 1 -0.29 14 15
GRB2 -0.005 0.006 -10000 0 -10000 0 0
JAK2 -0.006 0.023 0.24 2 -0.31 2 4
LBP -0.14 0.22 0.57 1 -0.67 28 29
PIK3R1 -0.075 0.13 -10000 0 -0.31 131 131
JAK1 -0.011 0.021 -10000 0 -0.32 2 2
MYC -0.22 0.36 -10000 0 -0.95 86 86
FGG -0.18 0.28 -10000 0 -0.8 60 60
macrophage differentiation -0.21 0.34 -10000 0 -0.97 63 63
IL6/IL6RA/gp130 (dimer)/JAK2/JAK2/LMO4 -0.024 0.056 0.19 3 -0.22 14 17
JUNB -0.28 0.41 -10000 0 -0.96 138 138
FOS -0.029 0.11 0.24 26 -0.31 65 91
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 -0.044 0.089 0.39 1 -0.36 16 17
STAT1/PIAS1 -0.046 0.099 -10000 0 -0.39 9 9
GRB2/SOS1/GAB family/SHP2/PI3K -0.014 0.092 0.5 1 -0.26 13 14
STAT3 (dimer) -0.23 0.37 -10000 0 -1 68 68
PRKCD -0.12 0.18 0.5 1 -0.51 49 50
IL6R -0.01 0.01 -10000 0 -10000 0 0
SOCS3 0.001 0.087 0.52 1 -0.94 2 3
gp130 (dimer)/JAK1/JAK1/LMO4 -0.02 0.046 0.21 1 -0.2 17 18
Rac1/GTP -0.065 0.11 0.39 1 -0.39 17 18
HCK -0.005 0.011 0.24 1 -10000 0 1
MAPKKK cascade -0.018 0.1 0.42 1 -0.54 13 14
bone resorption -0.17 0.27 -10000 0 -0.75 60 60
IRF1 -0.18 0.3 -10000 0 -0.83 60 60
mol:GDP -0.047 0.09 0.37 1 -0.35 16 17
SOS1 0.006 0.05 0.24 24 -10000 0 24
VAV1 -0.047 0.091 0.37 1 -0.35 16 17
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/SOCS3 -0.001 0.065 0.42 1 -0.46 5 6
PTPN11 -0.007 0.023 -10000 0 -10000 0 0
IL6/IL6RA -0.013 0.04 0.17 11 -0.22 9 20
gp130 (dimer)/TYK2/TYK2/LMO4 -0.015 0.04 0.16 6 -0.19 16 22
gp130 (dimer)/JAK2/JAK2/LMO4 -0.015 0.044 0.16 8 -0.2 17 25
IL6 -0.011 0.053 0.24 10 -0.32 9 19
PIAS3 -0.005 0.01 0.24 1 -10000 0 1
PTPRE 0.005 0.019 -10000 0 -10000 0 0
PIAS1 -0.005 0.01 0.24 1 -10000 0 1
RAC1 -0.008 0.013 -10000 0 -0.31 1 1
IL6/IL6RA/gp130 (dimer)/TYK2/TYK2/LMO4 -0.024 0.06 0.21 1 -0.28 13 14
LMO4 -0.007 0.037 0.24 10 -0.31 1 11
STAT3 (dimer)/PIAS3 -0.21 0.33 -10000 0 -0.87 77 77
MCL1 -0.018 0.084 0.68 1 -10000 0 1
E-cadherin signaling in keratinocytes

Figure S62.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S62.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
keratinocyte differentiation -0.029 0.1 0.17 3 -0.2 104 107
adherens junction organization -0.016 0.065 0.2 1 -0.26 22 23
mol:GTP 0 0 -10000 0 -10000 0 0
Rac1/GDP -0.031 0.089 0.18 3 -0.27 20 23
FMN1 -0.02 0.064 -10000 0 -0.26 22 22
mol:IP3 -0.017 0.084 0.16 3 -0.26 10 13
E-cadherin/Ca2+/beta catenin-gamma catenin/alpha catenin/p120 catenin -0.016 0.064 0.15 2 -0.27 20 22
CTNNB1 -0.003 0.016 0.24 2 -10000 0 2
AKT1 -0.019 0.085 0.18 2 -0.3 8 10
E-cadherin/beta catenin-gamma catenin/alpha catenin/p120 catenin -0.016 0.059 -10000 0 -0.35 13 13
CTNND1 -0.005 0.007 -10000 0 -10000 0 0
mol:PI-4-5-P2 -0.012 0.065 0.17 7 -0.25 20 27
VASP -0.017 0.061 -10000 0 -0.26 20 20
ZYX -0.032 0.077 -10000 0 -0.26 30 30
JUB -0.011 0.068 0.2 3 -0.26 20 23
EGFR(dimer) -0.026 0.074 0.2 1 -0.25 31 32
E-cadherin/beta catenin-gamma catenin 0 0.039 0.15 2 -0.17 24 26
mol:PI-3-4-5-P3 -0.014 0.094 0.14 94 -0.29 10 104
PIK3CA 0.044 0.1 0.23 122 -10000 0 122
PI3K -0.014 0.096 0.14 94 -0.29 10 104
FYN -0.054 0.12 0.16 2 -0.3 74 76
mol:Ca2+ -0.017 0.083 0.16 3 -0.25 10 13
JUP -0.011 0.046 -10000 0 -0.31 13 13
PIK3R1 -0.073 0.13 -10000 0 -0.31 131 131
mol:DAG -0.017 0.084 0.16 3 -0.26 10 13
CDH1 -0.011 0.046 -10000 0 -0.31 13 13
RhoA/GDP -0.032 0.088 0.18 3 -0.27 19 22
establishment of polarity of embryonic epithelium -0.017 0.06 -10000 0 -0.26 20 20
SRC -0.006 0 -10000 0 -10000 0 0
RAC1 -0.006 0.013 -10000 0 -0.31 1 1
RHOA -0.007 0.018 -10000 0 -0.31 2 2
EGFR -0.03 0.083 0.24 1 -0.31 46 47
CASR -0.018 0.079 0.16 2 -0.26 8 10
RhoA/GTP -0.02 0.077 -10000 0 -0.26 8 8
AKT2 -0.018 0.086 0.19 3 -0.3 8 11
actin cable formation -0.021 0.062 -10000 0 -0.25 22 22
apoptosis 0.024 0.092 0.18 104 -0.18 2 106
CTNNA1 -0.006 0.02 -10000 0 -0.31 2 2
mol:GDP -0.031 0.092 0.19 3 -0.28 20 23
PIP5K1A -0.012 0.066 0.17 7 -0.26 20 27
PLCG1 -0.018 0.085 0.16 3 -0.26 10 13
Rac1/GTP -0.028 0.068 0.17 1 -0.23 32 33
homophilic cell adhesion -0.001 0.004 -10000 0 -10000 0 0
Class I PI3K signaling events

Figure S63.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S63.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
ARF5/GTP 0.063 0.07 0.2 54 -10000 0 54
DAPP1 -0.023 0.062 -10000 0 -0.3 1 1
Src family/SYK family/BLNK-LAT/BTK-ITK 0.001 0.072 0.2 1 -0.31 4 5
mol:DAG 0.03 0.067 0.16 51 -0.15 2 53
HRAS 0.005 0.011 -10000 0 -10000 0 0
RAP1A 0.005 0.014 0.23 1 -10000 0 1
ARF5/GDP 0.032 0.035 0.16 3 -10000 0 3
PLCG2 -0.006 0 -10000 0 -10000 0 0
PLCG1 -0.004 0.023 0.24 5 -10000 0 5
ARF5 -0.006 0 -10000 0 -10000 0 0
mol:GTP 0.067 0.073 0.22 54 -10000 0 54
ARF1/GTP 0.059 0.07 0.21 49 -10000 0 49
RHOA -0.007 0.018 -10000 0 -0.31 2 2
YES1 0.006 0.052 0.24 26 -10000 0 26
RAP1A/GTP 0.066 0.071 0.21 54 -10000 0 54
ADAP1 0.064 0.07 0.21 54 -10000 0 54
ARAP3 0.066 0.072 0.22 54 -10000 0 54
INPPL1 -0.005 0.015 0.24 2 -10000 0 2
PREX1 -0.005 0.01 0.24 1 -10000 0 1
ARHGEF6 -0.003 0.025 0.24 6 -10000 0 6
ARHGEF7 -0.005 0.01 0.24 1 -10000 0 1
ARF1 -0.021 0.066 -10000 0 -0.31 29 29
NRAS 0.12 0.12 0.23 300 -10000 0 300
FYN -0.047 0.1 0.24 1 -0.31 79 80
ARF6 -0.006 0.013 -10000 0 -0.31 1 1
FGR -0.006 0 -10000 0 -10000 0 0
mol:Ca2+ 0.017 0.038 0.12 17 -10000 0 17
mol:IP4 0 0 -10000 0 -10000 0 0
TIAM1 -0.005 0.019 0.24 2 -0.31 1 3
ZAP70 -0.006 0 -10000 0 -10000 0 0
mol:IP3 0.02 0.048 0.12 48 -0.12 1 49
LYN -0.014 0.048 -10000 0 -0.31 15 15
ARF1/GDP 0.03 0.034 0.16 3 -10000 0 3
RhoA/GDP 0.046 0.054 0.16 5 -10000 0 5
PDK1/Src/Hsp90 0.008 0.008 -10000 0 -0.18 1 1
BLNK -0.014 0.048 -10000 0 -0.31 15 15
actin cytoskeleton reorganization 0.063 0.067 0.19 66 -10000 0 66
SRC -0.006 0 -10000 0 -10000 0 0
PLEKHA2 -0.005 0.012 0.16 2 -0.18 1 3
RAC1 -0.006 0.013 -10000 0 -0.31 1 1
PTEN -0.015 0.038 -10000 0 -0.28 11 11
HSP90AA1 -0.006 0.013 -10000 0 -0.31 1 1
ARF6/GTP 0.063 0.07 0.2 54 -0.14 1 55
RhoA/GTP 0.062 0.07 0.2 54 -10000 0 54
Src family/SYK family/BLNK-LAT -0.029 0.066 -10000 0 -0.31 4 4
BLK -0.005 0.01 0.24 1 -10000 0 1
PDPK1 -0.006 0 -10000 0 -10000 0 0
CYTH1 0.064 0.07 0.21 54 -10000 0 54
HCK -0.005 0.01 0.24 1 -10000 0 1
CYTH3 0.064 0.07 0.21 54 -10000 0 54
CYTH2 0.064 0.07 0.21 54 -10000 0 54
KRAS 0.032 0.076 0.23 71 -10000 0 71
GO:0030676 0 0 -10000 0 -10000 0 0
FOXO3 0.042 0.048 0.2 7 -10000 0 7
SGK1 0.033 0.037 -10000 0 -10000 0 0
INPP5D 0 0 -10000 0 -10000 0 0
mol:GDP 0.033 0.035 0.17 3 -10000 0 3
SOS1 0.005 0.05 0.24 24 -10000 0 24
SYK -0.008 0.034 0.24 2 -0.31 6 8
ARF6/GDP 0.063 0.068 0.18 76 -10000 0 76
mol:PI-3-4-5-P3 0.068 0.074 0.22 54 -10000 0 54
ARAP3/RAP1A/GTP 0.066 0.072 0.21 54 -10000 0 54
VAV1 -0.004 0.021 0.24 4 -10000 0 4
mol:PI-3-4-P2 -0.003 0.012 0.2 2 -10000 0 2
RAS family/GTP/PI3K Class I 0.085 0.088 0.15 331 -10000 0 331
PLEKHA1 -0.003 0.022 0.16 10 -10000 0 10
Rac1/GDP 0.032 0.035 0.16 3 -10000 0 3
LAT -0.006 0 -10000 0 -10000 0 0
Rac1/GTP 0.016 0.029 -10000 0 -0.21 2 2
ITK 0.066 0.074 0.22 61 -10000 0 61
Src family/SYK family/BLNK-LAT/BTK-ITK/PLC-gamma 0.033 0.08 0.19 49 -0.21 2 51
LCK -0.006 0 -10000 0 -10000 0 0
BTK 0.068 0.077 0.22 72 -10000 0 72
Neurotrophic factor-mediated Trk receptor signaling

Figure S64.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S64.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CRKL -0.006 0 -10000 0 -10000 0 0
RAS family/GTP/Tiam1 0.079 0.077 0.21 92 -10000 0 92
NT3 (dimer)/TRKC 0.019 0.063 0.17 82 -10000 0 82
NT3 (dimer)/TRKB 0.03 0.051 0.16 80 -10000 0 80
SHC/Grb2/SOS1/GAB1/PI3K -0.018 0.096 0.22 8 -0.18 108 116
RAPGEF1 -0.006 0 -10000 0 -10000 0 0
BDNF -0.006 0 -10000 0 -10000 0 0
PIK3CA 0.047 0.1 0.24 122 -10000 0 122
DYNLT1 -0.038 0.093 -10000 0 -0.31 61 61
NTRK1 -0.006 0 -10000 0 -10000 0 0
NTRK2 -0.004 0.018 0.24 3 -10000 0 3
NTRK3 -0.004 0.018 0.24 3 -10000 0 3
NT-4/5 (dimer)/TRKB 0.007 0.012 0.15 4 -10000 0 4
neuron apoptosis 0.019 0.07 0.27 18 -10000 0 18
SHC 2-3/Grb2 -0.021 0.075 -10000 0 -0.29 18 18
SHC1 -0.006 0 -10000 0 -10000 0 0
SHC2 -0.03 0.1 0.18 1 -0.4 33 34
SHC3 -0.005 0.046 0.18 1 -10000 0 1
STAT3 (dimer) -0.088 0.13 0.18 1 -0.29 160 161
NT3 (dimer)/TRKA 0.03 0.052 0.16 81 -10000 0 81
RIN/GDP 0.029 0.042 0.17 10 -10000 0 10
GIPC1 -0.002 0.029 0.24 8 -10000 0 8
KRAS 0.025 0.082 0.24 71 -10000 0 71
DNAJA3 -0.012 0.059 0.2 3 -10000 0 3
RIN/GTP -0.003 0 -10000 0 -10000 0 0
CCND1 -0.16 0.25 0.41 1 -0.56 150 151
MAGED1 -0.007 0.024 0.24 1 -0.31 3 4
PTPN11 -0.006 0 -10000 0 -10000 0 0
RICS -0.075 0.13 -10000 0 -0.31 130 130
NT-4/5 (dimer) 0 0 -10000 0 -10000 0 0
SHC/GRB2/SOS1 0.015 0.03 0.16 24 -10000 0 24
GRB2 -0.006 0 -10000 0 -10000 0 0
NGF (dimer)/TRKA/MATK 0.006 0 -10000 0 -10000 0 0
TRKA/NEDD4-2 -0.005 0.024 0.17 9 -0.21 1 10
ELMO1 0.001 0.041 0.24 16 -10000 0 16
RhoG/GTP/ELMO1/DOCK1 0.01 0.027 0.15 17 -0.18 2 19
NGF 0 0 -10000 0 -10000 0 0
HRAS -0.006 0 -10000 0 -10000 0 0
DOCK1 -0.006 0.021 0.24 1 -0.31 2 3
GAB2 -0.006 0.061 0.24 15 -0.31 13 28
RIT2 -0.006 0 -10000 0 -10000 0 0
RIT1 0.016 0.07 0.24 50 -10000 0 50
FRS2 0.001 0.04 0.24 15 -10000 0 15
DNM1 -0.006 0.013 -10000 0 -0.31 1 1
mol:GTP 0 0 -10000 0 -10000 0 0
CRK -0.005 0.01 0.24 1 -10000 0 1
SH2B1 (homopentamer) 0 0 -10000 0 -10000 0 0
RhoG/GTP -0.009 0.063 0.18 16 -10000 0 16
mol:GDP 0.038 0.053 0.22 10 -10000 0 10
NGF (dimer) 0 0 -10000 0 -10000 0 0
RhoG/GDP 0.001 0.028 0.17 16 -10000 0 16
RIT1/GDP 0.039 0.054 0.19 29 -10000 0 29
TIAM1 -0.005 0.019 0.24 2 -0.31 1 3
PIK3R1 -0.075 0.13 -10000 0 -0.31 131 131
BDNF (dimer)/TRKB 0.01 0.011 0.16 3 -10000 0 3
KIDINS220/CRKL/C3G -0.007 0 -10000 0 -10000 0 0
SHC/RasGAP -0.008 0.015 -10000 0 -0.21 3 3
FRS2 family/SHP2 0.013 0.024 0.16 15 -10000 0 15
SHC/GRB2/SOS1/GAB1 0.016 0.03 0.15 24 -0.16 2 26
RIT1/GTP 0.012 0.048 0.17 50 -10000 0 50
NT3 (dimer) 0.029 0.086 0.24 80 -10000 0 80
RAP1/GDP 0.002 0.012 -10000 0 -10000 0 0
KIDINS220/CRKL -0.006 0 -10000 0 -10000 0 0
BDNF (dimer) -0.006 0 -10000 0 -10000 0 0
ubiquitin-dependent protein catabolic process 0.008 0.02 0.15 9 -0.17 1 10
Schwann cell development -0.004 0.007 -10000 0 -10000 0 0
EHD4 -0.006 0 -10000 0 -10000 0 0
FRS2 family/GRB2/SOS1 0.021 0.035 0.15 39 -10000 0 39
FRS2 family/SHP2/CRK family/C3G/GAB2 -0.002 0.033 0.18 2 -10000 0 2
RAP1B -0.004 0.023 0.24 5 -10000 0 5
RAP1A -0.005 0.01 0.24 1 -10000 0 1
CDC42/GTP -0.012 0.005 -10000 0 -10000 0 0
ABL1 -0.008 0.028 -10000 0 -0.31 5 5
SH2B family/GRB2/SOS1 0.001 0.036 0.17 24 -10000 0 24
Rap1/GTP -0.002 0.021 0.17 4 -10000 0 4
STAT3 -0.088 0.13 0.18 1 -0.29 160 161
axon guidance -0.011 0.005 -10000 0 -10000 0 0
MAPK3 -0.011 0.024 -10000 0 -0.16 14 14
MAPK1 -0.007 0.009 0.16 1 -0.16 1 2
CDC42/GDP 0.029 0.042 0.16 13 -10000 0 13
NTF3 0.029 0.086 0.24 80 -10000 0 80
NTF4 0 0 -10000 0 -10000 0 0
NGF (dimer)/TRKA/FAIM 0.005 0.011 -10000 0 -0.18 2 2
PI3K -0.015 0.12 0.17 98 -0.21 107 205
FRS3 -0.006 0 -10000 0 -10000 0 0
FAIM -0.007 0.018 -10000 0 -0.31 2 2
GAB1 -0.007 0.018 -10000 0 -0.31 2 2
RASGRF1 -0.012 0.059 0.19 2 -10000 0 2
SOS1 0.005 0.05 0.24 24 -10000 0 24
MCF2L 0.015 0.056 0.15 82 -10000 0 82
RGS19 -0.006 0 -10000 0 -10000 0 0
CDC42 -0.006 0 -10000 0 -10000 0 0
RAS family/GTP 0.051 0.068 0.24 21 -10000 0 21
Rac1/GDP 0.029 0.042 0.17 10 -10000 0 10
NGF (dimer)/TRKA/GRIT -0.035 0.076 -10000 0 -0.18 130 130
neuron projection morphogenesis -0.083 0.15 -10000 0 -0.48 35 35
NGF (dimer)/TRKA/NEDD4-2 0.008 0.02 0.15 9 -0.18 1 10
MAP2K1 -0.006 0.028 0.15 1 -0.15 2 3
NGFR -0.005 0.01 0.24 1 -10000 0 1
NGF (dimer)/TRKA/GIPC/GAIP -0.021 0.058 -10000 0 -0.18 62 62
RAS family/GTP/PI3K 0.057 0.11 0.23 96 -0.18 50 146
FRS2 family/SHP2/GRB2/SOS1 0.022 0.033 -10000 0 -10000 0 0
NRAS 0.12 0.12 0.24 300 -10000 0 300
GRB2/SOS1 0.001 0.036 0.17 24 -10000 0 24
PRKCI 0.1 0.12 0.24 255 -10000 0 255
ChemicalAbstracts:146-91-8 0 0 -10000 0 -10000 0 0
RAC1 -0.006 0.013 -10000 0 -0.31 1 1
PRKCZ -0.006 0 -10000 0 -10000 0 0
MAPKKK cascade 0.002 0.038 -10000 0 -0.41 2 2
RASA1 -0.007 0.022 -10000 0 -0.31 3 3
TRKA/c-Abl -0.009 0.019 -10000 0 -0.21 5 5
SQSTM1 -0.006 0 -10000 0 -10000 0 0
BDNF (dimer)/TRKB/GIPC -0.005 0.058 0.15 11 -0.16 61 72
NGF (dimer)/TRKA/p62/Atypical PKCs 0.069 0.065 -10000 0 -10000 0 0
MATK -0.006 0 -10000 0 -10000 0 0
NEDD4L -0.002 0.033 0.24 9 -0.31 1 10
RAS family/GDP -0.003 0.007 -10000 0 -10000 0 0
NGF (dimer)/TRKA -0.011 0.061 0.2 2 -0.15 1 3
Rac1/GTP -0.011 0.021 -10000 0 -10000 0 0
FRS2 family/SHP2/CRK family 0.016 0.023 0.28 1 -10000 0 1
LPA4-mediated signaling events

Figure S65.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S65.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
ADCY4 -0.005 0.01 0.16 2 -10000 0 2
ADCY5 -0.004 0.014 0.16 4 -10000 0 4
ADCY6 -0.005 0.007 0.16 1 -10000 0 1
ADCY7 -0.005 0.007 0.16 1 -10000 0 1
ADCY1 -0.005 0.007 0.16 1 -10000 0 1
ADCY2 -0.005 0.007 0.16 1 -10000 0 1
ADCY3 -0.005 0.01 0.16 2 -10000 0 2
ADCY8 -0.085 0.09 0.16 10 -0.18 277 287
PRKCE -0.003 0.008 0.2 1 -10000 0 1
ADCY9 -0.018 0.046 0.16 1 -0.18 44 45
mol:DAG 0 0 -10000 0 -10000 0 0
cAMP biosynthetic process -0.048 0.043 0.14 1 -10000 0 1
Caspase cascade in apoptosis

Figure S66.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S66.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TOP1 0.042 0.061 0.19 30 -0.18 1 31
ACTA1 0.015 0.067 0.16 21 -0.21 7 28
NUMA1 0.042 0.061 0.19 31 -0.18 1 32
SPTAN1 0.022 0.064 0.18 15 -0.22 5 20
LIMK1 0.023 0.063 0.18 15 -0.22 5 20
BIRC3 -0.047 0.12 0.24 16 -0.31 90 106
BIRC2 0.059 0.11 0.24 149 -10000 0 149
BAX -0.006 0 -10000 0 -10000 0 0
CASP10 -0.003 0.048 0.17 30 -0.18 13 43
CRMA 0 0 -10000 0 -10000 0 0
XIAP 0 0 -10000 0 -10000 0 0
PTK2 0.046 0.062 0.19 30 -0.18 1 31
DIABLO 0.077 0.12 0.24 190 -10000 0 190
apoptotic nuclear changes 0.021 0.064 0.18 15 -0.22 5 20
response to UV 0 0 -10000 0 -10000 0 0
CRADD -0.006 0 -10000 0 -10000 0 0
GSN 0.006 0.076 0.17 10 -0.23 11 21
MADD -0.006 0 -10000 0 -10000 0 0
TFAP2A 0.038 0.053 -10000 0 -10000 0 0
BID -0.001 0.031 0.17 2 -0.13 13 15
MAP3K1 0.012 0.05 -10000 0 -0.43 4 4
TRADD -0.01 0.036 -10000 0 -0.31 8 8
mol:Ca2+ 0 0 -10000 0 -10000 0 0
APAF-1/Pro-Caspase 9 0.003 0.031 0.17 18 -10000 0 18
mol:Activated DNA 0 0 -10000 0 -10000 0 0
ARHGDIB 0.013 0.063 0.18 11 -0.21 6 17
CASP9 -0.004 0.011 0.24 1 -10000 0 1
DNA repair -0.034 0.062 -10000 0 -0.16 59 59
neuron apoptosis 0.008 0.081 -10000 0 -0.6 9 9
mol:NAD 0 0 -10000 0 -10000 0 0
DNA fragmentation during apoptosis 0.04 0.065 0.18 39 -0.2 2 41
APAF1 0.002 0.042 0.24 17 -10000 0 17
CASP6 0.048 0.073 0.24 11 -10000 0 11
TRAF2 -0.006 0 -10000 0 -10000 0 0
ICAD/CAD 0.02 0.061 0.17 14 -0.21 5 19
CASP7 0.034 0.086 0.21 90 -0.22 16 106
KRT18 0.018 0.041 -10000 0 -0.52 2 2
apoptosis 0.029 0.084 0.21 31 -0.22 4 35
DFFA 0.023 0.063 0.18 15 -0.22 5 20
DFFB 0.023 0.063 0.18 15 -0.22 5 20
PARP1 0.034 0.062 0.16 58 -10000 0 58
actin filament polymerization -0.019 0.061 0.21 5 -0.17 13 18
TNF -0.005 0.01 0.24 1 -10000 0 1
CYCS -0.001 0.029 0.14 4 -10000 0 4
SATB1 -0.006 0.091 0.22 4 -0.29 1 5
SLK 0.023 0.064 0.19 15 -0.22 5 20
p15 BID/BAX -0.004 0.026 0.17 1 -10000 0 1
CASP2 -0.028 0.072 -10000 0 -0.34 11 11
JNK cascade -0.012 0.049 0.43 4 -10000 0 4
CASP3 0.027 0.068 0.17 44 -0.23 5 49
LMNB2 0.013 0.058 0.18 5 -0.25 4 9
RIPK1 -0.006 0 -10000 0 -10000 0 0
CASP4 -0.015 0.055 0.24 2 -0.31 18 20
Mammalian IAPs/DIABLO 0.066 0.12 0.18 240 -0.16 53 293
negative regulation of DNA binding 0.038 0.052 -10000 0 -10000 0 0
stress fiber formation 0.023 0.064 0.19 15 -0.22 5 20
GZMB -0.002 0.056 0.21 26 -0.21 13 39
CASP1 -0.026 0.1 0.17 19 -0.3 57 76
LMNB1 0.061 0.067 0.17 75 -10000 0 75
APP 0.008 0.082 -10000 0 -0.61 9 9
TNFRSF1A -0.016 0.054 -10000 0 -0.31 19 19
response to stress 0 0 -10000 0 -10000 0 0
CASP8 -0.004 0 -10000 0 -10000 0 0
VIM 0.032 0.086 0.21 34 -0.23 4 38
LMNA 0.012 0.063 0.18 5 -0.31 5 10
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP1/TRAF2/RAIDD/PIDD -0.031 0.075 -10000 0 -0.35 12 12
LRDD -0.006 0 -10000 0 -10000 0 0
SREBF1 0.022 0.065 0.18 15 -0.21 7 22
APAF-1/Caspase 9 -0.038 0.12 -10000 0 -0.27 65 65
nuclear fragmentation during apoptosis 0.042 0.061 0.18 31 -0.18 1 32
CFL2 0.019 0.061 0.17 13 -0.21 5 18
GAS2 0.025 0.067 0.2 20 -0.22 5 25
positive regulation of apoptosis 0.038 0.063 0.19 13 -0.24 4 17
PRF1 -0.012 0.046 0.24 1 -0.31 13 14
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)

Figure S67.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S67.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
MET/RANBP9 0.008 0.065 0.17 61 -0.21 12 73
CRKL 0.005 0.054 0.19 1 -0.38 3 4
mol:PIP3 0.008 0.041 0.29 11 -10000 0 11
AKT1 0.001 0.03 0.2 11 -10000 0 11
PTK2B -0.006 0.013 -10000 0 -0.31 1 1
RAPGEF1 0.002 0.052 0.18 1 -0.36 3 4
RANBP10 -0.006 0.013 -10000 0 -0.31 1 1
PIK3CA 0.047 0.1 0.24 122 -10000 0 122
HGF/MET/SHIP2 0.021 0.055 0.16 63 -0.18 12 75
MAP3K5 0.003 0.051 0.2 1 -0.31 5 6
HGF/MET/CIN85/CBL/ENDOPHILINS 0.023 0.053 0.15 63 -0.16 12 75
AP1 -0.01 0.081 0.2 34 -0.18 60 94
mol:SU11274 0 0 -10000 0 -10000 0 0
SHC1 -0.006 0 -10000 0 -10000 0 0
apoptosis -0.063 0.23 0.3 6 -0.69 66 72
STAT3 (dimer) 0.006 0.058 0.21 7 -0.3 3 10
GAB1/CRKL/SHP2/PI3K -0.002 0.097 0.22 16 -0.34 6 22
INPP5D 0 0 -10000 0 -10000 0 0
CBL/CRK 0.003 0.052 0.18 1 -0.36 3 4
PTPN11 -0.006 0 -10000 0 -10000 0 0
GO:0007205 0 0 -10000 0 -10000 0 0
PLCG1 -0.004 0.023 0.24 5 -10000 0 5
PTEN -0.012 0.042 -10000 0 -0.31 11 11
ELK1 0.015 0.063 0.17 71 -10000 0 71
mol:SU5416 0 0 -10000 0 -10000 0 0
SHP2/GRB2/SOS1GAB1 -0.001 0.025 -10000 0 -0.15 1 1
PAK1 0.003 0.035 0.19 11 -10000 0 11
HGF/MET/RANBP10 0.02 0.054 0.16 60 -0.18 12 72
HRAS 0.007 0.089 0.27 2 -0.51 12 14
DOCK1 0.002 0.053 0.18 1 -0.35 4 5
GAB1 0.007 0.057 0.19 2 -0.26 13 15
CRK 0.005 0.054 0.19 1 -0.38 3 4
mol:PHA665752 0 0 -10000 0 -10000 0 0
mol:GDP 0.01 0.082 0.28 2 -0.45 12 14
JUN -0.001 0.042 0.24 14 -0.31 2 16
EntrezGene:200958 0 0 -10000 0 -10000 0 0
HGF/MET 0.007 0.048 0.12 60 -0.19 12 72
PIK3R1 -0.075 0.13 -10000 0 -0.31 131 131
cell morphogenesis -0.005 0.094 0.21 25 -0.3 8 33
GRB2/SHC 0.012 0.04 0.18 2 -0.17 12 14
FOS -0.029 0.11 0.24 26 -0.31 65 91
GLMN 0.024 0.051 0.13 102 -10000 0 102
cell motility 0.015 0.063 0.17 71 -10000 0 71
HGF/MET/MUC20 0.018 0.054 0.15 61 -0.18 12 73
cell migration 0.012 0.04 0.17 2 -0.17 12 14
GRB2 -0.006 0 -10000 0 -10000 0 0
CBL -0.006 0 -10000 0 -10000 0 0
MET/RANBP10 0.007 0.064 0.17 59 -0.21 13 72
HGF/MET/Paxillin/FAK1/FAK12/RasGAP 0.007 0.058 0.22 7 -0.36 1 8
MET/MUC20 0.01 0.061 0.17 59 -0.21 12 71
RAP1B 0.001 0.05 0.19 2 -0.34 3 5
RAP1A 0.001 0.05 0.17 1 -0.34 3 4
HGF/MET/RANBP9 0.021 0.054 0.16 62 -0.18 12 74
RAF1 0.005 0.085 0.26 2 -0.48 12 14
STAT3 0.006 0.058 0.21 7 -0.3 3 10
cell proliferation 0.001 0.066 0.2 8 -0.31 12 20
RPS6KB1 0.018 0.036 0.13 18 -10000 0 18
MAPK3 0.023 0.11 0.63 15 -10000 0 15
MAPK1 0.008 0.055 0.65 1 -10000 0 1
RANBP9 -0.004 0.018 0.24 3 -10000 0 3
MAPK8 -0.003 0.058 -10000 0 -0.3 3 3
SRC 0.004 0.054 0.2 7 -0.34 1 8
PI3K 0.009 0.1 0.17 98 -0.15 111 209
MET/Glomulin 0.032 0.069 0.2 59 -0.18 9 68
SOS1 0.005 0.05 0.24 24 -10000 0 24
MAP2K1 0.003 0.08 0.25 3 -0.45 12 15
MET 0.014 0.089 0.24 59 -0.31 12 71
MAP4K1 0.005 0.051 -10000 0 -0.36 3 3
PTK2 0.006 0.054 0.24 28 -10000 0 28
MAP2K2 -0.017 0.09 0.25 2 -0.46 12 14
BAD -0.001 0.028 0.19 11 -10000 0 11
MAP2K4 0 0.05 0.2 1 -0.31 4 5
SHP2/GRB2/SOS1/GAB1 -0.002 0.044 -10000 0 -0.28 13 13
INPPL1 -0.005 0.015 0.24 2 -10000 0 2
PXN -0.01 0.033 -10000 0 -0.31 7 7
SH3KBP1 -0.005 0.01 0.24 1 -10000 0 1
HGS 0.004 0.044 0.2 2 -0.18 12 14
PLCgamma1/PKC -0.002 0.016 0.17 5 -10000 0 5
HGF -0.004 0.021 0.24 4 -10000 0 4
RASA1 -0.007 0.022 -10000 0 -0.31 3 3
NCK1 0.012 0.065 0.24 42 -10000 0 42
PTPRJ -0.004 0.018 0.24 3 -10000 0 3
NCK/PLCgamma1 0.015 0.06 0.16 49 -0.17 12 61
PDPK1 0.004 0.034 0.23 11 -10000 0 11
HGF/MET/SHIP 0.018 0.054 0.15 61 -0.18 12 73
EPHB forward signaling

Figure S68.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S68.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Ephrin A5/EPHB2 0.009 0.026 0.15 14 -0.18 3 17
cell-cell adhesion 0.02 0.027 -10000 0 -10000 0 0
Ephrin B/EPHB2/RasGAP 0.01 0.047 -10000 0 -0.15 30 30
ITSN1 -0.005 0.01 0.24 1 -10000 0 1
PIK3CA 0.047 0.1 0.24 122 -10000 0 122
SHC1 -0.006 0 -10000 0 -10000 0 0
Ephrin B1/EPHB3 0.01 0.028 0.15 19 -0.18 1 20
Ephrin B1/EPHB1 0.009 0.023 0.15 12 -0.18 1 13
HRAS/GDP -0.022 0.043 -10000 0 -0.2 27 27
Ephrin B/EPHB1/GRB7 0.011 0.049 -10000 0 -0.15 30 30
Endophilin/SYNJ1 -0.011 0.039 0.14 1 -0.14 27 28
KRAS 0.025 0.082 0.24 71 -10000 0 71
Ephrin B/EPHB1/Src 0.011 0.046 -10000 0 -0.15 27 27
endothelial cell migration -0.005 0.092 0.13 104 -0.16 118 222
GRB2 -0.006 0 -10000 0 -10000 0 0
GRB7 -0.006 0.03 0.24 4 -0.31 3 7
PAK1 -0.008 0.05 0.16 19 -10000 0 19
HRAS -0.006 0 -10000 0 -10000 0 0
RRAS -0.024 0.056 -10000 0 -0.15 75 75
DNM1 -0.006 0.013 -10000 0 -0.31 1 1
cell-cell signaling 0 0 -10000 0 -10000 0 0
CRK -0.011 0.04 0.14 1 -0.14 27 28
lamellipodium assembly -0.02 0.027 -10000 0 -10000 0 0
Ephrin B/EPHB1/Src/p52 SHC/GRB2 -0.007 0.046 -10000 0 -0.18 23 23
PIK3R1 -0.075 0.13 -10000 0 -0.31 131 131
EPHB2 -0.001 0.033 0.24 10 -10000 0 10
EPHB3 0.002 0.044 0.24 19 -10000 0 19
EPHB1 -0.001 0.036 0.24 12 -10000 0 12
EPHB4 -0.006 0 -10000 0 -10000 0 0
mol:GDP -0.015 0.055 0.14 2 -0.22 27 29
Ephrin B/EPHB2 0.008 0.044 0.14 25 -0.15 27 52
Ephrin B/EPHB3 0.01 0.048 0.15 31 -0.15 26 57
JNK cascade 0.004 0.045 0.2 7 -0.15 1 8
Ephrin B/EPHB1 0.009 0.045 0.14 27 -0.15 27 54
RAP1/GDP -0.016 0.053 0.2 2 -0.21 22 24
EFNB2 -0.011 0.073 0.24 16 -0.31 23 39
EFNB3 -0.008 0.025 -10000 0 -0.31 4 4
EFNB1 -0.006 0.013 -10000 0 -0.31 1 1
Ephrin B2/EPHB1-2 0.011 0.051 0.16 36 -0.16 23 59
RAP1B -0.004 0.023 0.24 5 -10000 0 5
RAP1A -0.005 0.01 0.24 1 -10000 0 1
CDC42/GTP -0.019 0.042 -10000 0 -0.18 27 27
Rap1/GTP -0.022 0.027 -10000 0 -10000 0 0
axon guidance 0.008 0.026 0.15 14 -0.17 3 17
MAPK3 -0.013 0.048 -10000 0 -0.29 3 3
MAPK1 -0.01 0.042 -10000 0 -10000 0 0
Rac1/GDP -0.016 0.053 -10000 0 -0.22 23 23
actin cytoskeleton reorganization -0.012 0.025 -10000 0 -0.15 11 11
CDC42/GDP -0.016 0.053 -10000 0 -0.22 23 23
PI3K -0.002 0.097 0.14 106 -0.16 118 224
EFNA5 -0.006 0.03 0.24 4 -0.31 3 7
Ephrin B2/EPHB4 0.003 0.044 0.15 16 -0.18 23 39
Ephrin B/EPHB2/Intersectin/N-WASP -0.007 0.046 -10000 0 -0.18 27 27
CDC42 -0.006 0 -10000 0 -10000 0 0
RAS family/GTP -0.01 0.02 -10000 0 -10000 0 0
PTK2 0.013 0.081 0.37 28 -10000 0 28
MAP4K4 0.004 0.046 0.21 7 -0.15 1 8
SRC -0.006 0 -10000 0 -10000 0 0
KALRN -0.004 0.023 0.24 5 -10000 0 5
Intersectin/N-WASP -0.007 0.007 0.17 1 -10000 0 1
neuron projection morphogenesis -0.013 0.051 0.2 7 -10000 0 7
MAP2K1 -0.008 0.043 -10000 0 -0.18 23 23
WASL -0.006 0 -10000 0 -10000 0 0
Ephrin B1/EPHB1-2/NCK1 0.027 0.047 0.16 61 -0.16 1 62
cell migration -0.013 0.052 -10000 0 -0.21 27 27
NRAS 0.12 0.12 0.24 300 -10000 0 300
SYNJ1 -0.011 0.039 0.14 1 -0.14 27 28
PXN -0.01 0.033 -10000 0 -0.31 7 7
TF -0.011 0.04 -10000 0 -10000 0 0
HRAS/GTP -0.017 0.034 0.1 15 -10000 0 15
Ephrin B1/EPHB1-2 0.013 0.03 0.16 20 -0.16 1 21
cell adhesion mediated by integrin 0.01 0.039 0.16 27 -0.14 13 40
RAC1 -0.006 0.013 -10000 0 -0.31 1 1
mol:GTP -0.01 0.047 0.23 2 -10000 0 2
RAC1-CDC42/GTP -0.022 0.027 -10000 0 -10000 0 0
RASA1 -0.007 0.022 -10000 0 -0.31 3 3
RAC1-CDC42/GDP -0.017 0.051 -10000 0 -0.21 23 23
ruffle organization -0.016 0.042 0.21 2 -10000 0 2
NCK1 0.012 0.065 0.24 42 -10000 0 42
receptor internalization -0.013 0.039 -10000 0 -0.27 1 1
Ephrin B/EPHB2/KALRN 0.012 0.047 0.28 1 -0.15 26 27
ROCK1 -0.003 0.026 0.13 20 -0.16 1 21
RAS family/GDP -0.012 0.027 -10000 0 -0.16 11 11
Rac1/GTP -0.021 0.029 -10000 0 -10000 0 0
Ephrin B/EPHB1/Src/Paxillin -0.009 0.051 -10000 0 -0.19 33 33
BMP receptor signaling

Figure S69.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S69.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BMP7/BMPR2/BMPR1A-1B/FS 0.007 0.094 0.3 6 -0.17 90 96
SMAD6-7/SMURF1 0.01 0.012 0.16 4 -10000 0 4
NOG -0.005 0.019 0.24 2 -0.31 1 3
SMAD9 -0.01 0.053 -10000 0 -0.45 6 6
SMAD4 -0.006 0 -10000 0 -10000 0 0
SMAD5 -0.023 0.061 -10000 0 -0.27 4 4
BMP7/USAG1 0.025 0.11 0.18 141 -0.22 41 182
SMAD5/SKI -0.024 0.059 -10000 0 -0.26 4 4
SMAD1 -0.009 0.027 -10000 0 -0.28 3 3
BMP2 -0.006 0 -10000 0 -10000 0 0
SMAD1/SMAD1/SMAD4 -0.017 0.022 -10000 0 -0.25 3 3
BMPR1A -0.006 0.033 0.24 4 -0.31 4 8
BMPR1B -0.034 0.092 0.24 3 -0.31 56 59
BMPR1A-1B/BAMBI 0.003 0.073 0.16 50 -0.18 56 106
AHSG -0.006 0 -10000 0 -10000 0 0
CER1 -0.005 0.01 0.24 1 -10000 0 1
BMP2-4/CER1 0.012 0.021 0.16 12 -10000 0 12
BMP2-4/BMPR2/BMPR1A-1B/RGM/ENDOFIN/GADD34/PP1CA -0.033 0.07 0.17 2 -0.31 7 9
BMP2-4 (homodimer) -0.004 0.024 0.17 11 -10000 0 11
RGMB -0.006 0 -10000 0 -10000 0 0
BMP6/BMPR2/BMPR1A-1B -0.005 0.057 0.15 9 -0.16 61 70
RGMA -0.013 0.047 -10000 0 -0.31 14 14
SMURF1 -0.006 0 -10000 0 -10000 0 0
BMP2-4/BMPR2/BMPR1A-1B/RGM/XIAP -0.02 0.06 0.19 1 -0.31 3 4
BMP2-4/USAG1 0.038 0.061 0.16 116 -0.18 2 118
SMAD6/SMURF1/SMAD5 -0.024 0.059 -10000 0 -0.26 4 4
SOSTDC1 0.041 0.1 0.24 111 -0.31 2 113
BMP7/BMPR2/BMPR1A-1B -0.007 0.087 0.15 49 -0.18 92 141
SKI -0.006 0 -10000 0 -10000 0 0
BMP6 (homodimer) -0.005 0.015 0.24 2 -10000 0 2
HFE2 -0.006 0 -10000 0 -10000 0 0
ZFYVE16 -0.002 0.029 0.24 8 -10000 0 8
MAP3K7 -0.003 0.025 0.24 6 -10000 0 6
BMP2-4/CHRD 0.012 0.02 0.16 11 -10000 0 11
SMAD5/SMAD5/SMAD4 -0.024 0.059 -10000 0 -0.26 4 4
MAPK1 -0.006 0.016 0.24 1 -0.31 1 2
TAK1/TAB family -0.023 0.054 -10000 0 -0.27 3 3
BMP7 (homodimer) -0.01 0.11 0.24 46 -0.31 45 91
NUP214 -0.006 0 -10000 0 -10000 0 0
BMP6/FETUA -0.006 0.01 0.17 2 -10000 0 2
SMAD1/SKI -0.01 0.026 -10000 0 -0.27 3 3
SMAD6 -0.004 0.021 0.24 4 -10000 0 4
CTDSP2 -0.007 0.018 -10000 0 -0.31 2 2
BMP2-4/FETUA 0.012 0.02 0.16 11 -10000 0 11
MAP3K7IP1 -0.006 0 -10000 0 -10000 0 0
GREM1 0.004 0.048 0.24 22 -10000 0 22
BMPR2 (homodimer) -0.006 0.013 -10000 0 -0.31 1 1
GADD34/PP1CA -0.005 0.055 0.16 7 -0.18 48 55
BMPR1A-1B (homodimer) -0.026 0.067 0.17 7 -0.21 60 67
CHRDL1 -0.14 0.15 0.24 2 -0.31 263 265
ENDOFIN/SMAD1 -0.008 0.031 0.18 1 -0.27 3 4
SMAD6-7/SMURF1/SMAD1 -0.012 0.027 -10000 0 -0.26 3 3
SMAD6/SMURF1 -0.006 0 -10000 0 -10000 0 0
BAMBI 0.015 0.07 0.24 48 -0.31 1 49
SMURF2 -0.005 0.01 0.24 1 -10000 0 1
BMP2-4/CHRDL1 -0.074 0.096 0.16 7 -0.18 259 266
BMP2-4/GREM1 0.017 0.035 0.16 33 -10000 0 33
SMAD7 -0.006 0 -10000 0 -10000 0 0
SMAD8A/SMAD8A/SMAD4 -0.007 0.051 -10000 0 -0.43 6 6
SMAD1/SMAD6 -0.01 0.026 -10000 0 -0.27 3 3
TAK1/SMAD6 -0.005 0.018 0.17 6 -10000 0 6
BMP7 -0.01 0.11 0.24 46 -0.31 45 91
BMP6 -0.005 0.015 0.24 2 -10000 0 2
MAP3K7IP2 -0.004 0.018 0.24 3 -10000 0 3
BMP2-4/BMPR2/BMPR1A-1B/RGM/SMAD7/SMURF1 -0.018 0.055 0.16 1 -0.29 3 4
PPM1A -0.006 0 -10000 0 -10000 0 0
SMAD1/SMURF2 -0.01 0.027 -10000 0 -0.27 3 3
SMAD7/SMURF1 -0.007 0 -10000 0 -10000 0 0
CTDSPL -0.006 0 -10000 0 -10000 0 0
PPP1CA -0.006 0 -10000 0 -10000 0 0
XIAP 0 0 -10000 0 -10000 0 0
CTDSP1 -0.007 0.022 -10000 0 -0.31 3 3
PPP1R15A -0.032 0.086 0.24 1 -0.31 50 51
BMP2-4/BMPR2/BMPR1A-1B/RGM/FS -0.012 0.07 0.18 6 -0.38 3 9
CHRD -0.006 0 -10000 0 -10000 0 0
BMPR2 -0.006 0.013 -10000 0 -0.31 1 1
BMP2-4/BMPR2/BMPR1A-1B/RGM -0.021 0.061 0.18 1 -0.32 3 4
BMP4 -0.001 0.034 0.24 11 -10000 0 11
FST 0.017 0.072 0.24 53 -10000 0 53
BMP2-4/NOG 0.012 0.023 0.16 13 -0.18 1 14
BMP7/BMPR2/BMPR1A-1B/SMAD6/SMURF1 -0.005 0.083 0.28 1 -0.17 92 93
Regulation of cytoplasmic and nuclear SMAD2/3 signaling

Figure S70.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S70.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
SMAD4 -0.006 0 -10000 0 -10000 0 0
SMAD2 -0.001 0.027 0.17 1 -0.18 3 4
SMAD3 -0.01 0.035 -10000 0 -0.23 4 4
SMAD3/SMAD4 0.1 0.043 0.22 14 -10000 0 14
SMAD4/Ubc9/PIASy 0.009 0 -10000 0 -10000 0 0
SMAD2/SMAD2/SMAD4 0.12 0.056 0.23 33 -10000 0 33
PPM1A -0.006 0 -10000 0 -10000 0 0
CALM1 -0.012 0.042 -10000 0 -0.31 11 11
SMAD2/SMAD4 -0.003 0.023 -10000 0 -0.17 3 3
MAP3K1 -0.008 0.025 -10000 0 -0.31 4 4
TRAP-1/SMAD4 -0.007 0 -10000 0 -10000 0 0
MAPK3 -0.013 0.047 -10000 0 -0.31 14 14
MAPK1 -0.006 0.016 0.24 1 -0.31 1 2
NUP214 -0.006 0 -10000 0 -10000 0 0
CTDSP1 -0.007 0.022 -10000 0 -0.31 3 3
CTDSP2 -0.007 0.018 -10000 0 -0.31 2 2
CTDSPL -0.006 0 -10000 0 -10000 0 0
KPNB1 -0.006 0 -10000 0 -10000 0 0
TGFBRAP1 -0.006 0 -10000 0 -10000 0 0
UBE2I -0.006 0 -10000 0 -10000 0 0
NUP153 0.001 0.041 0.24 16 -10000 0 16
KPNA2 0.21 0.081 0.24 500 -10000 0 500
PIAS4 -0.006 0 -10000 0 -10000 0 0
IL12-mediated signaling events

Figure S71.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S71.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
IL12/IL12R/TYK2/JAK2/SOCS1 -0.03 0.086 0.29 9 -0.31 6 15
TBX21 -0.12 0.25 0.64 8 -0.62 3 11
B2M -0.009 0.031 -10000 0 -0.31 6 6
TYK2 -0.013 0.029 0.14 3 -10000 0 3
IL12RB1 -0.013 0.029 -10000 0 -10000 0 0
GADD45B -0.083 0.21 0.61 8 -10000 0 8
IL12RB2 -0.01 0.04 0.21 9 -10000 0 9
GADD45G -0.095 0.23 0.59 6 -1.1 8 14
natural killer cell activation -0.008 0.027 0.13 7 -10000 0 7
RELB -0.007 0.018 -10000 0 -0.31 2 2
RELA -0.006 0.013 -10000 0 -0.31 1 1
IL18 0.039 0.097 0.24 108 -10000 0 108
IL2RA -0.003 0.025 0.24 6 -10000 0 6
IFNG 0.006 0.052 0.24 26 -10000 0 26
STAT3 (dimer) -0.11 0.22 0.53 9 -0.64 10 19
HLA-DRB5 0.03 0.12 0.24 105 -0.31 19 124
FASLG -0.12 0.25 0.64 8 -10000 0 8
NF kappa B2 p52/RelB -0.16 0.2 -10000 0 -0.57 30 30
CD4 -0.001 0.038 0.24 11 -0.31 1 12
SOCS1 -0.012 0.043 -10000 0 -0.31 12 12
EntrezGene:6955 -0.001 0.012 -10000 0 -10000 0 0
CD3D -0.036 0.095 0.23 3 -0.31 59 62
CD3E -0.004 0.036 0.23 7 -0.31 3 10
CD3G 0.01 0.062 0.24 37 -10000 0 37
IL12Rbeta2/JAK2 -0.013 0.051 0.19 14 -0.22 2 16
CCL3 -0.12 0.26 0.72 13 -0.62 3 16
CCL4 -0.12 0.25 0.62 10 -0.57 29 39
HLA-A -0.007 0.018 -10000 0 -0.31 2 2
IL18/IL18R 0.019 0.071 0.3 7 -10000 0 7
NOS2 -0.1 0.23 0.57 14 -0.5 28 42
IL12/IL12R/TYK2/JAK2/SPHK2 -0.026 0.08 0.29 9 -10000 0 9
IL1R1 -0.39 0.54 0.64 5 -1 218 223
IL4 0.007 0.031 -10000 0 -0.15 3 3
JAK2 -0.013 0.037 0.22 2 -0.32 2 4
EntrezGene:6957 0 0.01 -10000 0 -10000 0 0
TCR/CD3/MHC I/CD8 -0.014 0.067 0.25 2 -0.35 5 7
RAB7A -0.074 0.2 0.58 5 -0.68 4 9
lysosomal transport -0.071 0.19 0.56 6 -0.64 4 10
FOS -0.17 0.41 0.55 24 -1 80 104
STAT4 (dimer) -0.077 0.23 0.6 10 -0.67 4 14
STAT5A (dimer) -0.15 0.2 0.36 2 -0.56 32 34
GZMA -0.12 0.26 0.68 8 -0.9 2 10
GZMB -0.12 0.26 0.69 11 -0.62 3 14
HLX -0.006 0 -10000 0 -10000 0 0
LCK -0.13 0.26 0.62 10 -0.6 29 39
TCR/CD3/MHC II/CD4 -0.05 0.17 0.27 30 -0.37 82 112
IL2/IL2R 0.011 0.059 0.18 31 -0.17 31 62
MAPK14 -0.085 0.22 0.59 8 -0.75 6 14
CCR5 -0.084 0.2 0.59 6 -10000 0 6
IL1B 0.004 0.072 0.24 43 -10000 0 43
STAT6 -0.044 0.13 0.38 9 -0.69 6 15
STAT4 -0.004 0.018 0.24 3 -10000 0 3
STAT3 -0.011 0.04 -10000 0 -0.31 10 10
STAT1 0.13 0.12 0.24 314 -10000 0 314
NFKB1 -0.01 0.033 -10000 0 -0.31 7 7
NFKB2 -0.006 0 -10000 0 -10000 0 0
IL12B -0.013 0.03 0.14 3 -10000 0 3
CD8A -0.006 0 -10000 0 -10000 0 0
CD8B -0.005 0.018 0.24 3 -10000 0 3
T-helper 1 cell differentiation 0 0 -10000 0 -10000 0 0
natural killer cell mediated cytotoxicity 0.03 0.086 0.3 6 -0.29 9 15
IL2RB -0.006 0.021 0.24 1 -0.31 2 3
proteasomal ubiquitin-dependent protein catabolic process -0.072 0.22 0.57 12 -0.62 4 16
IL2RG -0.009 0.09 0.24 30 -0.31 30 60
IL12 -0.009 0.054 0.2 8 -0.22 1 9
STAT5A -0.01 0.036 -10000 0 -0.31 8 8
CD247 -0.006 0.012 -10000 0 -10000 0 0
IL2 -0.006 0 -10000 0 -10000 0 0
SPHK2 -0.006 0 -10000 0 -10000 0 0
FRAP1 -0.006 0 -10000 0 -10000 0 0
IL12A -0.002 0.061 0.22 29 -0.32 1 30
IL12/IL12R/TYK2/JAK2 -0.14 0.27 0.7 10 -0.63 29 39
MAP2K3 -0.09 0.22 0.58 8 -0.73 6 14
RIPK2 0.073 0.12 0.24 180 -10000 0 180
MAP2K6 -0.08 0.21 0.59 8 -0.71 6 14
regulation of dendritic cell antigen processing and presentation 0 0 -10000 0 -10000 0 0
HLA-DRA -0.074 0.13 -10000 0 -0.31 129 129
IL18RAP -0.006 0.011 -10000 0 -10000 0 0
IL12Rbeta1/TYK2 -0.015 0.038 0.18 3 -10000 0 3
EOMES 0.006 0.043 -10000 0 -10000 0 0
STAT1 (dimer) -0.026 0.24 0.58 24 -0.57 3 27
T cell proliferation -0.053 0.19 0.52 12 -0.55 4 16
T-helper 1 cell lineage commitment 0 0 -10000 0 -10000 0 0
IL18R1 -0.005 0.015 0.24 1 -10000 0 1
CD8-positive alpha-beta T cell lineage commitment 0 0 -10000 0 -10000 0 0
NF kappa B1 p50/RelA -0.11 0.14 0.24 1 -0.53 8 9
ATF2 -0.082 0.2 0.56 8 -0.7 6 14
ErbB4 signaling events

Figure S72.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S72.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
ErbB4/ErbB4/HBEGF/HBEGF -0.018 0.069 0.3 2 -0.66 1 3
epithelial cell differentiation -0.02 0.039 -10000 0 -0.63 1 1
ITCH 0.003 0.029 0.22 6 -10000 0 6
WWP1 -0.011 0.081 0.5 3 -1.1 1 4
FYN -0.047 0.1 0.24 1 -0.31 79 80
EGFR -0.03 0.083 0.24 1 -0.31 46 47
PRL -0.005 0.01 0.24 1 -10000 0 1
neuron projection morphogenesis -0.012 0.063 0.27 2 -0.5 1 3
PTPRZ1 -0.004 0.018 0.24 3 -10000 0 3
ErbB4/ErbB4/neuregulin 1 beta/neuregulin 1 beta/GRB2/SHC -0.005 0.064 0.24 1 -0.54 1 2
ErbB4 CYT2/ErbB4 CYT2/neuregulin 1 beta/neuregulin 1 beta 0.003 0.078 0.32 4 -0.6 1 5
ADAM17 0.045 0.093 0.24 103 -10000 0 103
ErbB4/ErbB4 -0.014 0.083 0.46 3 -0.72 1 4
ErbB4/ErbB4/neuregulin 3/neuregulin 3 -0.13 0.11 0.29 1 -0.66 1 2
NCOR1 -0.007 0.018 -10000 0 -0.31 2 2
ErbB4/ErbB4/neuregulin 1 beta/neuregulin 1 beta/Fyn -0.02 0.089 0.28 4 -0.57 1 5
GRIN2B -0.021 0.084 0.27 4 -0.54 1 5
ErbB4/ErbB2/betacellulin 0.001 0.075 0.3 4 -0.57 1 5
STAT1 0.13 0.12 0.24 314 -10000 0 314
HBEGF -0.004 0.018 0.24 3 -10000 0 3
PRLR 0.003 0.046 0.24 20 -10000 0 20
E4ICDs/ETO2 -0.019 0.068 0.3 2 -0.66 1 3
axon guidance -0.001 0.061 0.34 3 -0.73 1 4
NEDD4 0.001 0.025 0.21 3 -10000 0 3
Prolactin receptor/Prolactin receptor/Prolactin 0 0.033 0.17 21 -10000 0 21
CBFA2T3 -0.006 0 -10000 0 -10000 0 0
ErbB4/ErbB2/HBEGF 0 0.072 0.29 4 -0.57 1 5
MAPK3 -0.01 0.064 0.27 2 -0.51 1 3
STAT1 (dimer) 0.077 0.11 0.38 6 -0.53 1 7
MAPK1 -0.007 0.062 0.24 4 -0.51 1 5
JAK2 -0.006 0.023 0.24 2 -0.31 2 4
ErbB4/ErbB2/neuregulin 1 beta 0.002 0.075 0.29 4 -0.57 1 5
NRG1 0.034 0.077 0.2 102 -10000 0 102
NRG3 -0.23 0.13 0.24 1 -0.31 425 426
NRG2 -0.006 0 -10000 0 -10000 0 0
NRG4 -0.008 0.062 0.24 13 -0.31 15 28
heart development -0.001 0.061 0.34 3 -0.73 1 4
neural crest cell migration 0.002 0.075 0.28 4 -0.56 1 5
ERBB2 0.034 0.077 0.19 106 -0.22 1 107
WWOX/E4ICDs -0.019 0.068 0.3 2 -0.66 1 3
SHC1 -0.006 0 -10000 0 -10000 0 0
ErbB4/EGFR/neuregulin 4 -0.032 0.08 -10000 0 -0.62 1 1
apoptosis 0.21 0.16 0.33 343 -0.3 1 344
ErbB4/ErbB4/neuregulin 2 beta/neuregulin 2 beta -0.019 0.068 0.3 2 -0.66 1 3
ErbB4/ErbB2/epiregulin 0 0.071 0.29 2 -0.57 1 3
ErbB4/ErbB4/betacellulin/betacellulin -0.017 0.074 0.3 3 -0.66 1 4
ErbB4/ErbB4/HBEGF/HBEGF/Prolactin receptor/Prolactin receptor/Prolactin/JAK2 -0.003 0.065 -10000 0 -0.58 1 1
MDM2 -0.016 0.07 0.38 2 -0.66 1 3
ErbB4 JM-B/ErbB4 JM-B/neuregulin 1 beta/neuregulin 1 beta 0.006 0.068 0.27 6 -0.53 1 7
STAT5A -0.005 0.058 0.32 2 -0.7 1 3
ErbB4/EGFR/neuregulin 1 beta -0.012 0.08 0.28 3 -0.57 1 4
DLG4 -0.006 0 -10000 0 -10000 0 0
GRB2/SHC -0.007 0 -10000 0 -10000 0 0
E4ICDs/TAB2/NCoR1 -0.02 0.061 -10000 0 -0.62 1 1
STAT5A (dimer) -0.01 0.055 -10000 0 -0.69 1 1
MAP3K7IP2 -0.004 0.018 0.24 3 -10000 0 3
STAT5B (dimer) -0.003 0.058 0.3 2 -0.7 1 3
LRIG1 -0.007 0.053 0.24 10 -0.31 11 21
EREG -0.005 0.01 0.24 1 -10000 0 1
BTC -0.004 0.04 0.24 9 -0.31 4 13
ErbB4/ErbB4/neuregulin 1 beta/neuregulin 1 beta -0.001 0.061 0.34 3 -0.74 1 4
ERBB4 -0.015 0.082 0.52 2 -0.72 1 3
STAT5B -0.012 0.042 -10000 0 -0.31 11 11
YAP1 0.005 0.027 -10000 0 -0.51 1 1
GRB2 -0.006 0 -10000 0 -10000 0 0
ErbB4/ErbB2/neuregulin 4 -0.001 0.08 0.29 3 -0.57 1 4
glial cell differentiation 0.019 0.061 0.61 1 -10000 0 1
WWOX -0.006 0 -10000 0 -10000 0 0
cell proliferation 0.004 0.071 0.32 2 -0.58 1 3
Lissencephaly gene (LIS1) in neuronal migration and development

Figure S73.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S73.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
DYNC1H1 -0.005 0.01 0.24 1 -10000 0 1
VLDLR -0.014 0.055 0.24 3 -0.31 17 20
LRPAP1 -0.006 0.025 0.24 3 -0.31 2 5
NUDC -0.006 0.013 -10000 0 -0.31 1 1
RELN/LRP8 -0.016 0.081 0.16 28 -0.18 97 125
CaM/Ca2+ -0.007 0.028 -10000 0 -0.21 11 11
KATNA1 -0.006 0 -10000 0 -10000 0 0
GO:0030286 0 0 -10000 0 -10000 0 0
ABL1 -0.03 0.07 0.13 29 -0.16 102 131
IQGAP1/CaM -0.011 0.032 0.17 1 -0.21 13 14
DAB1 -0.006 0 -10000 0 -10000 0 0
IQGAP1 -0.006 0.021 0.24 1 -0.31 2 3
PLA2G7 0.021 0.077 0.24 61 -10000 0 61
CALM1 -0.012 0.042 -10000 0 -0.31 11 11
DYNLT1 -0.038 0.093 -10000 0 -0.31 61 61
mol:Ca2+ 0 0 -10000 0 -10000 0 0
LRPAP1/LRP8 -0.005 0.025 0.17 9 -0.21 2 11
UniProt:Q4QZ09 0 0 -10000 0 -10000 0 0
CLIP1 -0.006 0 -10000 0 -10000 0 0
CDK5R1 -0.006 0 -10000 0 -10000 0 0
LIS1/Poliovirus Protein 3A -0.005 0.009 0.14 2 -10000 0 2
CDK5R2 -0.006 0 -10000 0 -10000 0 0
mol:PP1 0 0 -10000 0 -10000 0 0
RELN/VLDLR/DAB1 -0.022 0.083 0.16 24 -0.18 112 136
YWHAE -0.006 0.013 -10000 0 -0.31 1 1
NDEL1/14-3-3 E -0.016 0.071 0.26 3 -0.25 1 4
MAP1B -0.024 0.067 0.14 1 -0.22 61 62
RAC1 -0.003 0.016 -10000 0 -0.33 1 1
p35/CDK5 -0.015 0.076 0.28 3 -0.27 1 4
RELN -0.048 0.13 0.24 22 -0.31 97 119
PAFAH/LIS1 0.011 0.055 0.17 62 -10000 0 62
LIS1/CLIP170 -0.008 0.009 0.14 2 -10000 0 2
LIS1/NDEL1/Katanin 60/Dynein Light chain/Dynein heavy chain -0.044 0.051 -10000 0 -0.24 5 5
RELN/VLDLR/DAB1/LIS1/PAFAH1B2/PAFAH1B3 -0.03 0.081 0.2 3 -0.19 104 107
GO:0005869 0 0 -10000 0 -10000 0 0
NDEL1 -0.015 0.074 0.27 3 -0.26 1 4
LIS1/IQGAP1 -0.008 0.015 0.15 3 -0.18 2 5
RHOA -0.004 0.021 -10000 0 -0.33 2 2
PAFAH1B1 -0.006 0.012 0.2 2 -10000 0 2
PAFAH1B3 0.004 0.049 0.24 23 -10000 0 23
PAFAH1B2 -0.006 0 -10000 0 -10000 0 0
MAP1B/LIS1/Dynein heavy chain -0.02 0.044 0.16 1 -10000 0 1
NDEL1/Katanin 60/Dynein heavy chain -0.017 0.069 0.24 3 -0.25 1 4
LRP8 -0.003 0.025 0.24 6 -10000 0 6
NDEL1/Katanin 60 -0.016 0.071 0.26 3 -0.25 1 4
P39/CDK5 -0.015 0.076 0.28 3 -0.27 1 4
LIS1/NudC/Dynein intermediate chain/microtubule organizing center -0.008 0.011 0.14 2 -0.18 1 3
CDK5 -0.014 0.081 0.14 57 -0.15 94 151
PPP2R5D -0.006 0 -10000 0 -10000 0 0
LIS1/CLIP170/Dynein Complex/Dynactin Complex -0.006 0.008 0.12 2 -10000 0 2
CSNK2A1 -0.006 0 -10000 0 -10000 0 0
RELN/VLDLR/DAB1/LIS1 -0.032 0.068 0.15 24 -0.15 110 134
RELN/VLDLR -0.016 0.08 0.16 29 -0.16 110 139
CDC42 -0.003 0.008 -10000 0 -10000 0 0
Glypican 1 network

Figure S74.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S74.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
GPC1/FGF2 dimer/FGFR1 dimer 0 0.043 0.16 3 -0.18 28 31
fibroblast growth factor receptor signaling pathway 0 0.043 0.16 3 -0.18 28 31
LAMA1 0.036 0.093 0.24 96 -10000 0 96
PRNP -0.011 0.04 -10000 0 -0.31 10 10
GPC1/SLIT2 -0.022 0.07 0.17 18 -0.21 56 74
SMAD2 -0.012 0.021 0.13 1 -0.16 10 11
GPC1/PrPc/Cu2+ 0.003 0.024 -10000 0 -0.18 10 10
GPC1/Laminin alpha1 0.023 0.066 0.17 96 -10000 0 96
TDGF1 -0.006 0 -10000 0 -10000 0 0
CRIPTO/GPC1 -0.007 0 -10000 0 -10000 0 0
APP/GPC1 -0.01 0.026 -10000 0 -0.21 9 9
mol:NO 0 0 -10000 0 -10000 0 0
YES1 0 0.036 0.16 26 -10000 0 26
FLT1 -0.006 0 -10000 0 -10000 0 0
GPC1/TGFB/TGFBR1/TGFBR2 0.006 0.023 0.16 1 -0.18 8 9
SERPINC1 -0.006 0 -10000 0 -10000 0 0
FYN -0.031 0.059 0.16 1 -0.18 79 80
FGR -0.008 0 -10000 0 -10000 0 0
positive regulation of MAPKKK cascade -0.021 0.046 -10000 0 -0.22 1 1
SLIT2 -0.028 0.1 0.24 18 -0.31 56 74
GPC1/NRG -0.007 0.007 0.17 1 -10000 0 1
NRG1 -0.005 0.01 0.24 1 -10000 0 1
GPC1/VEGF165 homodimer/VEGFR1 homodimer 0.022 0.041 0.16 49 -10000 0 49
LYN -0.013 0.027 -10000 0 -0.18 15 15
mol:Spermine -0.003 0 -10000 0 -10000 0 0
cell growth 0 0.043 0.16 3 -0.18 28 31
BMP signaling pathway 0.006 0 -10000 0 -10000 0 0
SRC -0.008 0 -10000 0 -10000 0 0
TGFBR1 -0.005 0.01 0.24 1 -10000 0 1
mol:Cu2+ 0 0 -10000 0 -10000 0 0
PLA2G2A -0.13 0.15 0.24 5 -0.31 241 246
GPC1 -0.006 0 -10000 0 -10000 0 0
TGFBR1 (dimer) -0.005 0.01 0.24 1 -10000 0 1
VEGFA 0.016 0.069 0.24 49 -10000 0 49
BLK -0.008 0.007 0.16 1 -10000 0 1
HCK -0.008 0.007 0.16 1 -10000 0 1
FGF2 -0.011 0.04 -10000 0 -0.31 10 10
FGFR1 -0.015 0.057 0.24 3 -0.31 19 22
VEGFR1 homodimer -0.006 0 -10000 0 -10000 0 0
TGFBR2 -0.01 0.036 -10000 0 -0.31 8 8
cell death -0.01 0.026 -10000 0 -0.21 9 9
ATIII/GPC1 -0.007 0 -10000 0 -10000 0 0
PLA2G2A/GPC1 -0.092 0.1 0.17 5 -0.21 241 246
LCK -0.008 0 -10000 0 -10000 0 0
neuron differentiation -0.007 0.007 0.17 1 -10000 0 1
PrPc/Cu2+ -0.007 0.027 -10000 0 -0.21 10 10
APP -0.011 0.038 -10000 0 -0.31 9 9
TGFBR2 (dimer) -0.01 0.036 -10000 0 -0.31 8 8
Glucocorticoid receptor regulatory network

Figure S75.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S75.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PCK2 -0.047 0.048 -10000 0 -10000 0 0
SMARCC2 -0.005 0.01 0.24 1 -10000 0 1
SMARCC1 -0.005 0.01 0.24 1 -10000 0 1
TBX21 0.048 0.062 -10000 0 -10000 0 0
SUMO2 -0.009 0.006 -10000 0 -10000 0 0
STAT1 (dimer) 0.13 0.13 0.25 314 -0.17 5 319
FKBP4 0.006 0.054 0.24 28 -10000 0 28
FKBP5 -0.02 0.08 0.24 10 -0.31 34 44
GR alpha/HSP90/FKBP51/HSP90 -0.053 0.067 -10000 0 -0.27 18 18
PRL 0.029 0.051 0.58 1 -10000 0 1
cortisol/GR alpha (dimer)/TIF2 -0.091 0.13 -10000 0 -0.44 18 18
RELA 0.017 0.07 0.23 24 -0.2 6 30
FGG -0.1 0.12 -10000 0 -0.48 11 11
GR beta/TIF2 -0.053 0.059 -10000 0 -0.24 12 12
IFNG 0.099 0.16 0.53 32 -10000 0 32
apoptosis -0.15 0.2 0.4 2 -0.48 40 42
CREB1 -0.007 0 -10000 0 -10000 0 0
histone acetylation 0.035 0.067 -10000 0 -10000 0 0
BGLAP 0.046 0.059 0.56 1 -10000 0 1
GR/PKAc -0.04 0.047 -10000 0 -0.3 1 1
NF kappa B1 p50/RelA 0.035 0.13 0.41 24 -0.28 14 38
SMARCD1 -0.006 0 -10000 0 -10000 0 0
MDM2 -0.032 0.043 -10000 0 -0.3 2 2
GATA3 -0.006 0.015 0.24 2 -10000 0 2
AKT1 -0.005 0.01 0.24 1 -10000 0 1
CSF2 0.023 0.041 -10000 0 -10000 0 0
GSK3B -0.009 0.006 -10000 0 -10000 0 0
NR1I3 -0.14 0.17 -10000 0 -0.48 14 14
CSN2 -0.092 0.11 -10000 0 -0.4 18 18
BRG1/BAF155/BAF170/BAF60A 0.012 0.018 0.15 6 -0.16 2 8
NFATC1 -0.007 0.013 -10000 0 -0.31 1 1
POU2F1 -0.006 0.007 0.15 1 -10000 0 1
CDKN1A -0.066 0.22 -10000 0 -1.2 16 16
response to stress 0 0 -10000 0 -10000 0 0
response to UV -0.003 0.006 -10000 0 -10000 0 0
SFN 0.003 0.047 0.24 21 -10000 0 21
GR alpha/HSP90/FKBP51/HSP90/14-3-3 -0.044 0.066 -10000 0 -0.25 18 18
prolactin receptor activity 0 0 -10000 0 -10000 0 0
EGR1 -0.29 0.36 0.47 3 -0.75 212 215
JUN 0.09 0.14 0.45 36 -10000 0 36
IL4 0.045 0.056 -10000 0 -10000 0 0
CDK5R1 -0.008 0.004 -10000 0 -10000 0 0
PRKACA -0.006 0 -10000 0 -10000 0 0
cortisol/GR alpha (monomer)/AP-1 -0.047 0.06 -10000 0 -0.25 16 16
GR alpha/HSP90/FKBP51/HSP90/PP5C -0.049 0.061 -10000 0 -0.25 18 18
cortisol/GR alpha (monomer) -0.11 0.15 -10000 0 -0.5 18 18
NCOA2 -0.005 0.015 0.24 2 -10000 0 2
response to hypoxia 0 0 -10000 0 -10000 0 0
FOS 0.023 0.13 0.26 53 -0.31 45 98
AP-1/NFAT1-c-4 0.1 0.19 0.54 40 -10000 0 40
AFP 0.058 0.098 -10000 0 -10000 0 0
SUV420H1 -0.005 0.015 0.24 2 -10000 0 2
IRF1 0.026 0.16 0.52 14 -0.76 9 23
TP53 -0.064 0.13 0.24 1 -0.34 99 100
PPP5C -0.005 0.01 0.24 1 -10000 0 1
KRT17 0.093 0.16 0.61 26 -10000 0 26
KRT14 0.054 0.1 0.58 14 -10000 0 14
TBP -0.006 0.008 0.19 1 -10000 0 1
CREBBP -0.015 0.048 -10000 0 -0.31 11 11
HDAC1 0.01 0.06 0.24 36 -10000 0 36
HDAC2 -0.001 0.036 0.24 11 -0.31 1 12
AP-1 0.1 0.19 0.55 40 -10000 0 40
MAPK14 -0.009 0.012 0.24 1 -10000 0 1
MAPK10 -0.018 0.053 0.23 1 -0.31 17 18
MAPK11 -0.009 0.006 -10000 0 -10000 0 0
KRT5 0.14 0.22 0.56 104 -10000 0 104
interleukin-1 receptor activity 0 0 -10000 0 -10000 0 0
NCOA1 -0.007 0.018 -10000 0 -0.31 2 2
STAT1 0.13 0.13 0.25 314 -0.17 5 319
CGA 0.045 0.055 -10000 0 -10000 0 0
NF kappa B1 p50/RelA/Cbp/cortisol/GR alpha (monomer)/HDAC2 -0.043 0.071 -10000 0 -0.33 6 6
MAPK3 -0.017 0.047 -10000 0 -0.31 14 14
MAPK1 -0.009 0.017 0.23 1 -0.31 1 2
ICAM1 0.097 0.21 0.56 76 -0.85 5 81
NFKB1 0.013 0.077 0.23 24 -0.28 9 33
MAPK8 0.08 0.12 0.4 28 -10000 0 28
MAPK9 -0.009 0.018 0.24 1 -0.31 1 2
cortisol/GR alpha (dimer) -0.16 0.2 0.4 2 -0.5 42 44
BAX -0.041 0.11 -10000 0 -10000 0 0
POMC -0.019 0.12 -10000 0 -10000 0 0
EP300 -0.011 0.031 -10000 0 -0.19 16 16
cortisol/GR alpha (dimer)/p53 -0.13 0.14 -10000 0 -0.5 19 19
proteasomal ubiquitin-dependent protein catabolic process -0.027 0.04 0.24 2 -0.26 2 4
SGK1 -0.018 0.054 -10000 0 -0.24 27 27
IL13 0.07 0.11 0.47 7 -10000 0 7
IL6 0.057 0.17 0.61 12 -0.86 9 21
PRKACG -0.006 0 -10000 0 -10000 0 0
IL5 0.054 0.11 0.45 2 -10000 0 2
IL2 0.084 0.14 0.51 15 -10000 0 15
CDK5 0.02 0.079 0.24 65 -10000 0 65
PRKACB -0.001 0.033 0.24 10 -10000 0 10
HSP90AA1 -0.006 0.013 -10000 0 -0.31 1 1
IL8 0.093 0.18 0.56 60 -10000 0 60
CDK5R1/CDK5 0.01 0.056 0.16 65 -10000 0 65
NF kappa B1 p50/RelA/PKAc 0.029 0.11 0.32 26 -0.24 2 28
cortisol/GR alpha (dimer)/Hsp90/FKBP52/HSP90 -0.076 0.13 -10000 0 -0.44 11 11
SMARCA4 -0.005 0.027 0.24 4 -0.31 2 6
chromatin remodeling -0.063 0.079 -10000 0 -0.32 8 8
NF kappa B1 p50/RelA/Cbp 0.02 0.11 0.35 21 -10000 0 21
JUN (dimer) 0.09 0.14 0.45 36 -10000 0 36
YWHAH -0.007 0.022 -10000 0 -0.31 3 3
VIPR1 0.048 0.062 -10000 0 -10000 0 0
NR3C1 -0.079 0.086 -10000 0 -0.33 15 15
NR4A1 -0.12 0.15 0.24 4 -0.31 227 231
TIF2/SUV420H1 -0.006 0.015 0.17 4 -10000 0 4
MAPKKK cascade -0.15 0.2 0.4 2 -0.48 40 42
cortisol/GR alpha (dimer)/Src-1 -0.093 0.13 -10000 0 -0.44 18 18
PBX1 -0.012 0.042 0.15 1 -0.31 11 12
POU1F1 -0.006 0.007 0.15 1 -10000 0 1
SELE 0.063 0.11 0.43 8 -10000 0 8
cortisol/GR alpha/BRG1/BAF155/BAF170/BAF60A -0.064 0.08 -10000 0 -0.32 8 8
cortisol/GR alpha (monomer)/Hsp90/FKBP52/HSP90 -0.076 0.13 -10000 0 -0.44 11 11
mol:cortisol -0.068 0.078 -10000 0 -0.28 10 10
MMP1 0.13 0.22 0.54 121 -10000 0 121
ErbB2/ErbB3 signaling events

Figure S76.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S76.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
USP8 -0.003 0.025 0.18 9 -10000 0 9
RAS family/GTP 0.09 0.11 0.26 99 -0.2 1 100
NFATC4 -0.011 0.044 0.19 5 -10000 0 5
ERBB2IP -0.005 0.013 -10000 0 -0.3 1 1
HSP90 (dimer) -0.006 0.013 -10000 0 -0.31 1 1
mammary gland morphogenesis -0.003 0.066 0.3 8 -0.17 24 32
JUN 0.023 0.11 0.33 43 -10000 0 43
HRAS -0.004 0.005 -10000 0 -10000 0 0
DOCK7 -0.004 0.059 0.22 12 -0.18 3 15
ErbB2/ErbB3/neuregulin 1 beta/SHC -0.008 0.046 0.15 13 -0.16 26 39
AKT1 -0.003 0.009 0.2 1 -10000 0 1
BAD -0.005 0.007 0.16 1 -10000 0 1
MAPK10 -0.01 0.038 0.13 10 -0.13 4 14
mol:GTP 0 0.003 -10000 0 -10000 0 0
ErbB2/ErbB3/neuregulin 1 beta -0.002 0.071 0.32 8 -0.19 4 12
RAF1 0.075 0.12 0.36 46 -10000 0 46
ErbB2/ErbB3/neuregulin 2 -0.009 0.044 0.15 17 -0.16 27 44
STAT3 -0.011 0.12 -10000 0 -0.9 10 10
cell migration -0.007 0.041 0.15 10 -0.15 1 11
mol:PI-3-4-5-P3 0 0.001 -10000 0 -10000 0 0
cell proliferation 0.039 0.21 0.56 41 -0.54 4 45
FOS 0.019 0.23 0.52 54 -0.44 65 119
NRAS 0.13 0.12 0.24 300 -10000 0 300
mol:Ca2+ -0.003 0.066 0.3 8 -0.17 24 32
MAPK3 0.041 0.18 0.51 41 -0.48 6 47
MAPK1 0.049 0.18 0.51 42 -0.48 2 44
JAK2 -0.01 0.052 0.2 8 -0.18 4 12
NF2 -0.002 0.009 -10000 0 -10000 0 0
ErbB2/ErbB3/neuregulin 1 beta/SHC/GRB2/SOS1 -0.003 0.051 0.16 1 -0.2 25 26
NRG1 -0.004 0.012 0.25 1 -10000 0 1
GRB2/SOS1 0.002 0.036 0.17 24 -10000 0 24
MAPK8 -0.006 0.063 0.24 8 -0.22 21 29
MAPK9 -0.007 0.036 0.14 11 -10000 0 11
ERBB2 -0.003 0.026 0.21 6 -0.21 2 8
ERBB3 -0.012 0.073 0.24 12 -0.31 25 37
SHC1 -0.004 0.006 -10000 0 -10000 0 0
RAC1 -0.006 0.013 -10000 0 -0.31 1 1
apoptosis 0.005 0.01 -10000 0 -0.19 1 1
STAT3 (dimer) -0.011 0.12 -10000 0 -0.88 10 10
RNF41 -0.005 0.023 0.16 10 -10000 0 10
FRAP1 -0.005 0.007 0.16 1 -10000 0 1
RAC1-CDC42/GTP -0.019 0.026 -10000 0 -0.13 22 22
ErbB2/ErbB2/HSP90 (dimer) -0.005 0.021 0.15 6 -0.18 3 9
CHRNA1 0.05 0.17 0.53 42 -0.38 1 43
myelination -0.013 0.042 0.22 3 -10000 0 3
PPP3CB -0.01 0.049 0.19 9 -0.17 4 13
KRAS 0.026 0.082 0.24 71 -10000 0 71
RAC1-CDC42/GDP -0.006 0.045 -10000 0 -0.18 24 24
NRG2 -0.006 0 -10000 0 -10000 0 0
mol:GDP -0.003 0.051 0.16 1 -0.2 25 26
SOS1 0.006 0.05 0.24 24 -10000 0 24
MAP2K2 0.053 0.12 0.38 39 -0.26 3 42
SRC -0.006 0 -10000 0 -10000 0 0
mol:cAMP 0 0.001 -10000 0 -10000 0 0
PTPN11 -0.011 0.049 0.18 7 -0.17 4 11
MAP2K1 0.062 0.16 0.48 43 -0.41 2 45
heart morphogenesis -0.003 0.066 0.3 8 -0.17 24 32
RAS family/GDP 0.094 0.11 0.26 89 -0.19 1 90
GRB2 -0.004 0.005 -10000 0 -10000 0 0
PRKACA 0.001 0.005 -10000 0 -10000 0 0
CHRNE 0.008 0.038 0.26 7 -10000 0 7
HSP90AA1 -0.006 0.013 -10000 0 -0.31 1 1
activation of caspase activity 0.003 0.009 -10000 0 -0.2 1 1
nervous system development -0.003 0.066 0.3 8 -0.17 24 32
CDC42 -0.006 0 -10000 0 -10000 0 0
Role of Calcineurin-dependent NFAT signaling in lymphocytes

Figure S77.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S77.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BCL2L1 -0.005 0.01 0.24 1 -10000 0 1
NFATC1 0.057 0.033 -10000 0 -10000 0 0
NFATC2 -0.025 0.041 0.15 4 -0.16 16 20
NFATC3 -0.009 0.02 -10000 0 -10000 0 0
YWHAE -0.006 0.013 -10000 0 -0.31 1 1
Calcineurin A alpha-beta B1/CABIN1 -0.004 0.033 -10000 0 -0.31 1 1
Exportin 1/Ran/NUP214 0.013 0.043 0.15 46 -10000 0 46
mol:DAG -0.002 0.003 -10000 0 -10000 0 0
CABIN1/MEF2D/CaM/Ca2+/CAMK IV -0.018 0.035 -10000 0 -0.29 1 1
BCL2/BAX -0.04 0.076 0.17 1 -0.21 93 94
CaM/Ca2+/Calcineurin A alpha-beta B1 -0.013 0.03 -10000 0 -0.22 11 11
CaM/Ca2+ -0.013 0.03 -10000 0 -0.22 11 11
BAX -0.006 0 -10000 0 -10000 0 0
MAPK14 -0.007 0.011 0.24 1 -10000 0 1
BAD -0.006 0 -10000 0 -10000 0 0
CABIN1/MEF2D -0.008 0.031 -10000 0 -0.3 1 1
Calcineurin A alpha-beta B1/BCL2 -0.055 0.11 0.24 1 -0.31 93 94
FKBP8 -0.027 0.077 -10000 0 -0.31 40 40
activation-induced cell death of T cells 0.008 0.031 0.29 1 -10000 0 1
KPNB1 -0.006 0 -10000 0 -10000 0 0
KPNA2 0.21 0.081 0.24 500 -10000 0 500
XPO1 0.014 0.068 0.24 46 -10000 0 46
SFN 0.003 0.047 0.24 21 -10000 0 21
MAP3K8 -0.008 0.004 -10000 0 -10000 0 0
NFAT4/CK1 alpha -0.019 0.031 -10000 0 -0.19 15 15
MEF2D/NFAT1/Cbp/p300 -0.094 0.11 0.38 4 -0.31 21 25
CABIN1 -0.004 0.033 -10000 0 -0.31 1 1
CALM1 -0.015 0.042 -10000 0 -0.31 11 11
RAN -0.006 0.001 -10000 0 -10000 0 0
MAP3K1 -0.008 0.025 -10000 0 -0.31 4 4
CAMK4 -0.002 0.031 0.24 9 -10000 0 9
mol:Ca2+ -0.004 0.007 -10000 0 -10000 0 0
MAPK3 -0.013 0.047 -10000 0 -0.31 14 14
YWHAH -0.007 0.022 -10000 0 -0.31 3 3
Calcineurin A alpha-beta B1/AKAP79/PKA -0.008 0.003 -10000 0 -10000 0 0
YWHAB -0.005 0.01 0.24 1 -10000 0 1
MAPK8 -0.005 0.026 0.24 6 -10000 0 6
MAPK9 -0.006 0.016 0.24 1 -0.31 1 2
YWHAG -0.006 0 -10000 0 -10000 0 0
FKBP1A -0.006 0 -10000 0 -10000 0 0
NFAT1-c-4/YWHAQ 0.035 0.045 -10000 0 -10000 0 0
PRKCH -0.007 0.018 -10000 0 -0.31 2 2
CABIN1/Cbp/p300 -0.02 0.032 -10000 0 -0.22 13 13
CASP3 -0.003 0.033 0.24 10 -10000 0 10
PIM1 -0.004 0.018 0.24 3 -10000 0 3
Calcineurin A alpha-beta B1/FKBP12/FK506 -0.005 0.004 -10000 0 -10000 0 0
apoptosis -0.006 0.042 -10000 0 -10000 0 0
14-3-3 family/BAD/CaM/Ca2+/Calcineurin A alpha-beta B1 -0.004 0.029 -10000 0 -10000 0 0
PRKCB 0 0 -10000 0 -10000 0 0
PRKCE -0.005 0.01 0.24 1 -10000 0 1
JNK2/NFAT4 -0.011 0.02 0.16 1 -10000 0 1
BAD/BCL-XL -0.007 0.007 0.17 1 -10000 0 1
PRKCD -0.006 0.021 0.24 1 -0.31 2 3
NUP214 -0.006 0.001 -10000 0 -10000 0 0
PRKCZ -0.008 0.004 -10000 0 -10000 0 0
PRKCA -0.005 0.037 0.24 7 -0.31 4 11
PRKCG -0.006 0 -10000 0 -10000 0 0
PRKCQ -0.009 0.048 0.24 5 -0.31 11 16
FKBP38/BCL2 -0.054 0.092 0.17 1 -0.22 125 126
EP300 -0.012 0.02 -10000 0 -0.32 2 2
PRKCB1 -0.003 0.025 0.24 6 -10000 0 6
CSNK2A1 -0.006 0 -10000 0 -10000 0 0
NFATc/JNK1 0.054 0.037 0.22 4 -10000 0 4
CaM/Ca2+/FKBP38 -0.025 0.049 -10000 0 -0.18 51 51
FKBP12/FK506 -0.003 0 -10000 0 -10000 0 0
CSNK1A1 -0.014 0.027 0.16 2 -0.18 11 13
CaM/Ca2+/CAMK IV -0.01 0.03 0.15 8 -0.18 10 18
NFATc/ERK1 0.054 0.035 -10000 0 -10000 0 0
CABIN1/YWHAQ/CaM/Ca2+/CAMK IV -0.015 0.034 -10000 0 -0.28 1 1
NR4A1 -0.15 0.17 0.49 4 -0.35 227 231
GSK3B -0.008 0.004 -10000 0 -10000 0 0
positive T cell selection -0.009 0.02 -10000 0 -10000 0 0
NFAT1/CK1 alpha -0.028 0.042 0.13 5 -0.22 11 16
RCH1/ KPNB1 0.15 0.058 0.17 500 -10000 0 500
YWHAQ -0.006 0 -10000 0 -10000 0 0
PRKACA -0.007 0.003 -10000 0 -10000 0 0
AKAP5 -0.006 0 -10000 0 -10000 0 0
MEF2D -0.011 0.008 -10000 0 -10000 0 0
mol:FK506 0 0 -10000 0 -10000 0 0
YWHAZ -0.006 0 -10000 0 -10000 0 0
NFATc/p38 alpha 0.054 0.033 -10000 0 -10000 0 0
CREBBP -0.017 0.042 -10000 0 -0.31 11 11
BCL2 -0.055 0.11 0.24 1 -0.31 93 94
Stabilization and expansion of the E-cadherin adherens junction

Figure S78.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S78.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
adherens junction organization -0.013 0.045 -10000 0 -0.19 32 32
epithelial cell differentiation 0.006 0.026 0.13 2 -0.15 15 17
CYFIP2 -0.012 0.042 -10000 0 -0.31 11 11
ENAH -0.008 0.038 0.17 3 -10000 0 3
EGFR -0.03 0.083 0.24 1 -0.31 46 47
EPHA2 -0.005 0.01 0.24 1 -10000 0 1
MYO6 -0.012 0.035 0.14 11 -0.15 19 30
CTNNB1 -0.005 0.015 0.24 2 -10000 0 2
ABI1/Sra1/Nap1 0.008 0.032 0.16 10 -0.18 11 21
AQP5 0.019 0.062 -10000 0 -10000 0 0
CTNND1 -0.006 0 -10000 0 -10000 0 0
mol:PI-4-5-P2 -0.013 0.022 -10000 0 -0.14 15 15
regulation of calcium-dependent cell-cell adhesion -0.015 0.026 -10000 0 -0.14 20 20
EGF -0.003 0.027 0.24 7 -10000 0 7
NCKAP1 -0.002 0.031 0.24 9 -10000 0 9
AQP3 -0.12 0.17 -10000 0 -0.39 160 160
cortical microtubule organization 0.006 0.026 0.13 2 -0.15 15 17
GO:0000145 -0.013 0.021 -10000 0 -0.14 15 15
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.006 0.027 0.14 2 -0.15 15 17
MLLT4 -0.021 0.066 -10000 0 -0.31 29 29
ARF6/GDP -0.018 0.02 -10000 0 -10000 0 0
ARF6 -0.006 0.013 -10000 0 -0.31 1 1
Ephrin A1/EPHA2/NCK1/GIT1 0.029 0.049 0.16 68 -10000 0 68
mol:Ca2+ 0 0 -10000 0 -10000 0 0
VASP -0.04 0.077 -10000 0 -0.22 74 74
PVRL2 -0.006 0.016 0.24 1 -0.31 1 2
ZYX -0.031 0.051 -10000 0 -0.15 86 86
ARF6/GTP 0.027 0.043 0.26 3 -0.15 1 4
CDH1 -0.013 0.045 -10000 0 -0.31 13 13
EGFR/EGFR/EGF/EGF -0.026 0.042 -10000 0 -0.15 59 59
RhoA/GDP -0.014 0.023 -10000 0 -0.14 17 17
actin cytoskeleton organization -0.013 0.033 -10000 0 -0.27 1 1
IGF-1R heterotetramer -0.07 0.12 -10000 0 -0.31 121 121
GIT1 -0.005 0.01 0.24 1 -10000 0 1
IGF1R -0.07 0.12 -10000 0 -0.31 121 121
IGF1 -0.016 0.06 0.24 3 -0.31 21 24
DIAPH1 -0.003 0.08 -10000 0 -0.53 12 12
Wnt receptor signaling pathway -0.006 0.026 0.15 15 -0.13 2 17
RHOA -0.007 0.018 -10000 0 -0.31 2 2
RhoA/GTP -0.018 0.021 -10000 0 -10000 0 0
CTNNA1 -0.007 0.018 -10000 0 -0.31 2 2
VCL -0.013 0.033 -10000 0 -0.28 1 1
EFNA1 0.006 0.053 0.24 27 -10000 0 27
LPP -0.019 0.034 -10000 0 -0.33 2 2
Ephrin A1/EPHA2 -0.015 0.02 -10000 0 -0.14 14 14
SEC6/SEC8 -0.024 0.035 -10000 0 -0.15 38 38
MGAT3 -0.015 0.026 -10000 0 -0.14 20 20
HGF/MET -0.017 0.028 -10000 0 -0.14 26 26
HGF -0.004 0.021 0.24 4 -10000 0 4
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.013 0.045 -10000 0 -0.19 32 32
actin cable formation -0.022 0.057 0.15 3 -0.22 12 15
KIAA1543 -0.015 0.026 -10000 0 -0.39 1 1
KIFC3 -0.014 0.023 -10000 0 -10000 0 0
NCK1 0.012 0.065 0.24 42 -10000 0 42
EXOC3 -0.005 0.01 0.24 1 -10000 0 1
ACTN1 -0.016 0.031 -10000 0 -0.16 24 24
NCK1/GIT1 0.006 0.047 0.17 43 -10000 0 43
mol:GDP 0.006 0.026 0.13 2 -0.15 15 17
EXOC4 -0.004 0.021 0.24 4 -10000 0 4
STX4 -0.014 0.023 -10000 0 -0.14 15 15
PIP5K1C -0.014 0.023 -10000 0 -0.14 15 15
LIMA1 -0.015 0.053 -10000 0 -0.31 18 18
ABI1 -0.005 0.01 0.24 1 -10000 0 1
ROCK1 -0.007 0.041 0.18 3 -10000 0 3
adherens junction assembly -0.013 0.031 -10000 0 -0.55 1 1
IGF-1R heterotetramer/IGF1 -0.048 0.061 -10000 0 -0.15 151 151
nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin -0.017 0.046 0.17 1 -0.21 30 31
MET 0.014 0.089 0.24 59 -0.31 12 71
PLEKHA7 -0.014 0.025 -10000 0 -0.28 1 1
mol:GTP 0.028 0.047 0.15 68 -10000 0 68
establishment of epithelial cell apical/basal polarity -0.025 0.036 -10000 0 -0.25 4 4
cortical actin cytoskeleton stabilization -0.013 0.045 -10000 0 -0.19 32 32
regulation of cell-cell adhesion -0.013 0.033 -10000 0 -0.27 1 1
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.013 0.045 -10000 0 -0.19 32 32
PDGFR-beta signaling pathway

Figure S79.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S79.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
S1P1/Sphingosine-1-phosphate -0.023 0.054 -10000 0 -0.37 7 7
PDGFB-D/PDGFRB/SLAP -0.009 0.025 0.17 2 -0.21 7 9
PDGFB-D/PDGFRB/APS/CBL 0 0.02 -10000 0 -0.18 7 7
AKT1 -0.068 0.087 -10000 0 -0.26 38 38
mol:PI-4-5-P2 0 0 -10000 0 -10000 0 0
mol:Sphingosine-1-phosphate -0.02 0.052 -10000 0 -0.39 7 7
PIK3CA 0.047 0.1 0.24 122 -10000 0 122
FGR -0.011 0.031 -10000 0 -0.24 1 1
mol:Ca2+ -0.017 0.053 -10000 0 -0.42 7 7
MYC -0.088 0.22 -10000 0 -0.73 59 59
SHC1 -0.006 0 -10000 0 -10000 0 0
HRAS/GDP -0.014 0.018 -10000 0 -10000 0 0
LRP1/PDGFRB/PDGFB -0.001 0.03 -10000 0 -0.18 15 15
GRB10 -0.006 0 -10000 0 -10000 0 0
PTPN11 -0.006 0 -10000 0 -10000 0 0
GO:0007205 -0.017 0.053 -10000 0 -0.42 7 7
PTEN -0.012 0.042 -10000 0 -0.31 11 11
GRB2 -0.006 0 -10000 0 -10000 0 0
GRB7 -0.006 0.03 0.24 4 -0.31 3 7
PDGFB-D/PDGFRB/SHP2 -0.01 0.023 -10000 0 -0.21 7 7
PDGFB-D/PDGFRB/GRB10 -0.01 0.023 -10000 0 -0.21 7 7
cell cycle arrest -0.009 0.025 0.17 2 -0.21 7 9
HRAS -0.006 0 -10000 0 -10000 0 0
HIF1A -0.064 0.08 -10000 0 -0.23 40 40
GAB1 -0.028 0.064 -10000 0 -0.37 8 8
mol:GTP 0 0 -10000 0 -10000 0 0
DNM2 -0.029 0.062 -10000 0 -0.34 8 8
PDGFB-D/PDGFRB 0.002 0.024 -10000 0 -0.19 7 7
mol:GDP 0 0 -10000 0 -10000 0 0
PDGFB-D/PDGFRB/LMW-PTP 0.005 0.054 0.17 47 -0.21 7 54
S1P1/Sphingosine-1-phosphate/PDGFB-D/PDGFRB -0.034 0.065 -10000 0 -0.34 7 7
positive regulation of MAPKKK cascade -0.01 0.023 -10000 0 -0.21 7 7
PIK3R1 -0.075 0.13 -10000 0 -0.31 131 131
mol:IP3 -0.018 0.054 -10000 0 -0.42 7 7
E5 -0.001 0.001 -10000 0 -10000 0 0
CSK -0.004 0.004 -10000 0 -10000 0 0
PDGFB-D/PDGFRB/GRB7 -0.009 0.031 0.17 4 -0.21 10 14
SHB -0.006 0 -10000 0 -10000 0 0
BLK -0.01 0.03 -10000 0 -10000 0 0
PTPN2 -0.007 0.003 -10000 0 -10000 0 0
PDGFB-D/PDGFRB/SNX15 -0.01 0.023 -10000 0 -0.21 7 7
BCAR1 -0.006 0.013 -10000 0 -0.31 1 1
VAV2 -0.039 0.085 -10000 0 -0.34 17 17
CBL -0.006 0 -10000 0 -10000 0 0
PDGFB-D/PDGFRB/DEP1 -0.009 0.026 0.17 3 -0.21 7 10
LCK -0.01 0.03 -10000 0 -0.24 1 1
PDGFRB -0.01 0.034 -10000 0 -0.31 7 7
ACP1 0.015 0.068 0.24 47 -10000 0 47
HCK -0.011 0.031 -10000 0 -0.24 1 1
ABL1 -0.024 0.053 -10000 0 -0.3 8 8
PDGFB-D/PDGFRB/CBL -0.028 0.07 -10000 0 -0.46 7 7
PTPN1 -0.007 0.003 -10000 0 -10000 0 0
SNX15 -0.006 0 -10000 0 -10000 0 0
STAT3 -0.011 0.04 -10000 0 -0.31 10 10
STAT1 0.13 0.12 0.24 314 -10000 0 314
cell proliferation -0.078 0.2 -10000 0 -0.64 59 59
SLA -0.005 0.015 0.24 2 -10000 0 2
actin cytoskeleton reorganization -0.009 0.036 -10000 0 -10000 0 0
SRC -0.01 0.03 -10000 0 -10000 0 0
PI3K -0.08 0.08 -10000 0 -0.21 82 82
PDGFB-D/PDGFRB/GRB7/SHC 0.002 0.028 0.16 4 -0.18 10 14
SH2B2 0 0 -10000 0 -10000 0 0
PLCgamma1/SPHK1 -0.02 0.053 -10000 0 -0.4 7 7
LYN -0.024 0.087 -10000 0 -0.48 17 17
LRP1 -0.01 0.036 -10000 0 -0.31 8 8
SOS1 0.005 0.05 0.24 24 -10000 0 24
STAT5B -0.012 0.042 -10000 0 -0.31 11 11
STAT5A -0.01 0.036 -10000 0 -0.31 8 8
NCK1-2/p130 Cas 0.014 0.039 -10000 0 -10000 0 0
SPHK1 -0.006 0.011 0.24 1 -10000 0 1
EDG1 -0.009 0.031 -10000 0 -0.31 6 6
mol:DAG -0.018 0.054 -10000 0 -0.42 7 7
PLCG1 -0.018 0.055 -10000 0 -0.43 7 7
NHERF/PDGFRB -0.064 0.1 -10000 0 -0.21 184 184
YES1 -0.005 0.04 -10000 0 -0.22 6 6
cell migration -0.064 0.1 -10000 0 -0.2 184 184
SHC/Grb2/SOS1 0.011 0.032 -10000 0 -10000 0 0
SLC9A3R2 -0.048 0.1 -10000 0 -0.31 79 79
SLC9A3R1 -0.075 0.13 -10000 0 -0.31 130 130
NHERF1-2/PDGFRB/PTEN -0.058 0.098 -10000 0 -0.19 193 193
FYN -0.073 0.16 -10000 0 -0.46 80 80
DOK1 -0.013 0.019 -10000 0 -0.16 9 9
HRAS/GTP -0.003 0 -10000 0 -10000 0 0
PDGFB -0.006 0 -10000 0 -10000 0 0
RAC1 -0.059 0.14 -10000 0 -0.43 65 65
PRKCD -0.014 0.021 0.16 1 -0.17 9 10
FER -0.013 0.019 0.16 1 -0.17 7 8
MAPKKK cascade -0.011 0.029 -10000 0 -10000 0 0
RASA1 -0.014 0.021 -10000 0 -0.17 10 10
NCK1 0.012 0.065 0.24 42 -10000 0 42
NCK2 -0.006 0 -10000 0 -10000 0 0
p62DOK/Csk -0.013 0.018 -10000 0 -0.15 8 8
PDGFB-D/PDGFRB/SHB -0.01 0.023 -10000 0 -0.21 7 7
chemotaxis -0.023 0.052 -10000 0 -0.3 8 8
STAT1-3-5/STAT1-3-5 -0.013 0.028 -10000 0 -0.15 20 20
Bovine Papilomavirus E5/PDGFRB -0.007 0.023 -10000 0 -0.21 7 7
PTPRJ -0.004 0.018 0.24 3 -10000 0 3
Canonical Wnt signaling pathway

Figure S80.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S80.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
HDAC1 0.04 0.077 0.24 54 -10000 0 54
AES -0.013 0.1 0.15 15 -0.31 54 69
FBXW11 -0.006 0 -10000 0 -10000 0 0
mol:GTP 0.001 0.001 -10000 0 -10000 0 0
LRP6/FZD1 0.006 0.046 0.17 41 -10000 0 41
SMAD4 -0.006 0 -10000 0 -10000 0 0
DKK2 -0.005 0.002 -10000 0 -10000 0 0
TLE1 0.023 0.049 0.19 24 -10000 0 24
MACF1 -0.003 0.028 0.24 6 -0.31 1 7
CTNNB1 0.009 0.04 0.23 2 -10000 0 2
WIF1 0.002 0.033 0.24 10 -10000 0 10
beta catenin/RanBP3 0.12 0.18 0.36 190 -10000 0 190
KREMEN2 -0.005 0.003 -10000 0 -10000 0 0
DKK1 0.002 0.043 0.24 18 -10000 0 18
beta catenin/beta TrCP1 0.021 0.042 0.22 2 -10000 0 2
FZD1 -0.006 0.003 -10000 0 -10000 0 0
AXIN2 -0.073 0.13 0.53 1 -0.54 17 18
AXIN1 -0.004 0.004 -10000 0 -10000 0 0
RAN -0.001 0.006 -10000 0 -10000 0 0
Axin1/APC/GSK3/beta catenin 0.016 0.026 -10000 0 -10000 0 0
beta catenin/TCF/CtBP/CBP/TLE1/AES/SMAD4 -0.013 0.11 0.25 3 -0.31 5 8
Axin1/APC/GSK3 0.011 0.026 -10000 0 -10000 0 0
Axin1/APC/GSK3/beta catenin/Macf1 0.012 0.036 0.23 1 -10000 0 1
HNF1A 0.022 0.042 0.16 16 -10000 0 16
CTBP1 0.022 0.043 0.16 19 -10000 0 19
MYC -0.17 0.38 -10000 0 -1.3 59 59
RANBP3 -0.001 0.006 -10000 0 -10000 0 0
DKK2/LRP6/Kremen 2 0.02 0.038 0.16 41 -10000 0 41
NKD1 -0.006 0.01 0.24 1 -10000 0 1
TCF4 0.022 0.046 0.16 20 -0.31 1 21
TCF3 0.022 0.042 0.15 20 -10000 0 20
WNT1/LRP6/FZD1/Axin1 0.016 0.039 -10000 0 -10000 0 0
Ran/GTP 0.001 0.006 -10000 0 -10000 0 0
CtBP/CBP/TCF/TLE1/AES 0.13 0.23 0.47 150 -0.42 1 151
LEF1 0.038 0.079 0.23 59 -0.31 3 62
DVL1 0.017 0.028 0.19 1 -10000 0 1
CSNK2A1 -0.005 0.003 -10000 0 -10000 0 0
beta catenin/TCF/CtBP/CBP/TLE1/AES -0.1 0.15 -10000 0 -0.45 45 45
DKK1/LRP6/Kremen 2 0.023 0.044 0.16 57 -10000 0 57
LRP6 0.012 0.064 0.24 41 -10000 0 41
CSNK1A1 0.027 0.049 0.18 22 -10000 0 22
NLK -0.008 0.019 0.24 3 -10000 0 3
CCND1 -0.34 0.54 0.52 1 -1.2 150 151
WNT1 -0.006 0.003 -10000 0 -10000 0 0
GSK3A -0.006 0.013 -10000 0 -0.31 1 1
GSK3B -0.006 0.002 -10000 0 -10000 0 0
FRAT1 -0.007 0.013 -10000 0 -0.31 1 1
PPP2R5D 0.012 0.019 -10000 0 -0.22 1 1
APC -0.002 0.033 -10000 0 -10000 0 0
WNT1/LRP6/FZD1 0.009 0.032 -10000 0 -10000 0 0
CREBBP 0.018 0.052 0.15 20 -0.31 5 25
EGFR-dependent Endothelin signaling events

Figure S81.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S81.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
HRAS -0.006 0 -10000 0 -10000 0 0
EGFR -0.03 0.083 0.24 1 -0.31 46 47
EGF/EGFR -0.015 0.046 0.12 22 -0.14 47 69
EGF/EGFR dimer/SHC/GRB2/SOS1 0.007 0.054 0.28 2 -0.15 42 44
mol:GTP 0 0 -10000 0 -10000 0 0
EDNRA -0.004 0.018 0.24 3 -10000 0 3
response to oxidative stress 0 0 -10000 0 -10000 0 0
EGF -0.003 0.027 0.24 7 -10000 0 7
EGF/EGFR dimer/SHC -0.005 0.053 0.16 6 -0.18 46 52
mol:GDP 0.005 0.052 0.26 2 -0.15 42 44
mol:Ca2+ 0 0 -10000 0 -10000 0 0
EDN1 0 0.04 0.24 14 -0.31 1 15
GRB2/SOS1 0.001 0.036 0.17 24 -10000 0 24
HRAS/GTP -0.021 0.034 -10000 0 -0.14 42 42
SHC1 -0.006 0 -10000 0 -10000 0 0
HRAS/GDP -0.022 0.035 -10000 0 -0.14 42 42
FRAP1 -0.017 0.046 0.23 2 -10000 0 2
EGF/EGFR dimer -0.021 0.061 0.2 7 -0.21 46 53
SOS1 0.005 0.05 0.24 24 -10000 0 24
GRB2 -0.006 0 -10000 0 -10000 0 0
ETA receptor/Endothelin-1 -0.002 0.031 0.17 17 -0.21 1 18
Regulation of nuclear SMAD2/3 signaling

Figure S82.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S82.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
EP300 -0.001 0.024 -10000 0 -0.29 2 2
HSPA8 -0.007 0.004 -10000 0 -10000 0 0
SMAD3/SMAD4/ER alpha -0.052 0.074 0.16 2 -0.22 67 69
AKT1 -0.006 0.011 0.24 1 -10000 0 1
GSC -0.014 0.02 -10000 0 -10000 0 0
NKX2-5 -0.009 0.01 -10000 0 -10000 0 0
muscle cell differentiation 0 0.069 0.38 2 -0.22 4 6
SMAD2-3/SMAD4/SP1 0.027 0.096 0.29 10 -0.32 1 11
SMAD4 -0.003 0.048 0.17 6 -10000 0 6
CBFB -0.007 0.022 -10000 0 -0.31 3 3
SAP18 -0.007 0.013 -10000 0 -0.31 1 1
Cbp/p300/MSG1 0.016 0.042 0.17 12 -0.17 12 24
SMAD3/SMAD4/VDR 0.003 0.059 0.19 13 -0.21 1 14
MYC -0.037 0.092 -10000 0 -0.31 59 59
CDKN2B 0.004 0.036 -10000 0 -10000 0 0
AP1 -0.003 0.11 0.45 15 -0.28 7 22
SMAD2/SMAD2/SMAD4/SnoN/SIN3/HDAC complex/NCoR1 0.054 0.06 0.23 12 -10000 0 12
SMAD2-3/SMAD4/FOXO1-3a-4/FOXG1 -0.003 0.036 -10000 0 -0.25 1 1
SP3 -0.003 0.019 -10000 0 -10000 0 0
CREB1 -0.006 0 -10000 0 -10000 0 0
FOXH1 -0.009 0.01 -10000 0 -10000 0 0
SMAD3/SMAD4/GR -0.028 0.053 0.16 2 -0.23 10 12
GATA3 -0.009 0.015 0.24 2 -10000 0 2
SKI/SIN3/HDAC complex/NCoR1 0.003 0.038 0.18 10 -10000 0 10
MEF2C/TIF2 -0.021 0.063 -10000 0 -0.32 20 20
endothelial cell migration -0.07 0.17 -10000 0 -0.52 68 68
MAX -0.017 0.03 -10000 0 -0.13 7 7
RBBP7 -0.007 0.018 -10000 0 -0.31 2 2
RBBP4 0.002 0.043 0.24 18 -10000 0 18
RUNX2 -0.004 0.018 0.24 3 -10000 0 3
RUNX3 -0.005 0.01 0.24 1 -10000 0 1
RUNX1 -0.006 0 -10000 0 -10000 0 0
CTBP1 -0.006 0 -10000 0 -10000 0 0
NR3C1 -0.022 0.048 -10000 0 -0.31 10 10
VDR -0.005 0.01 0.24 1 -10000 0 1
CDKN1A 0.002 0.2 -10000 0 -1.1 16 16
KAT2B 0.001 0.004 -10000 0 -10000 0 0
SMAD2/SMAD2/SMAD4/FOXH1 -0.008 0.036 -10000 0 -10000 0 0
DCP1A -0.006 0 -10000 0 -10000 0 0
SKI -0.006 0.001 -10000 0 -10000 0 0
SERPINE1 0.07 0.17 0.52 68 -10000 0 68
SMAD3/SMAD4/ATF2 -0.012 0.042 0.18 8 -0.24 2 10
SMAD3/SMAD4/ATF3 -0.012 0.046 0.19 11 -0.26 3 14
SAP30 -0.006 0.001 -10000 0 -10000 0 0
Cbp/p300/PIAS3 0.017 0.045 0.16 1 -0.18 11 12
JUN -0.003 0.11 0.49 15 -0.3 4 19
SMAD3/SMAD4/IRF7 -0.013 0.045 0.18 10 -0.24 2 12
TFE3 0.009 0.04 0.17 8 -10000 0 8
COL1A2 0.14 0.24 0.47 183 -0.73 6 189
mesenchymal cell differentiation 0.012 0.044 0.24 2 -0.18 10 12
DLX1 -0.005 0.015 0.24 2 -10000 0 2
TCF3 -0.006 0 -10000 0 -10000 0 0
FOS -0.025 0.11 0.22 27 -0.32 59 86
SMAD3/SMAD4/Max -0.025 0.048 0.16 2 -0.23 3 5
Cbp/p300/SNIP1 0.009 0.031 0.16 2 -0.17 13 15
ZBTB17 -0.006 0 -10000 0 -10000 0 0
LAMC1 0.031 0.13 0.44 43 -10000 0 43
TGIF2/HDAC complex/SMAD3/SMAD4 -0.013 0.042 0.18 7 -0.23 3 10
IRF7 -0.008 0 -10000 0 -10000 0 0
ESR1 -0.065 0.11 -10000 0 -0.33 74 74
HNF4A -0.006 0 -10000 0 -10000 0 0
MEF2C -0.021 0.065 -10000 0 -0.33 20 20
SMAD2-3/SMAD4 -0.015 0.044 0.19 4 -0.23 3 7
Cbp/p300/Src-1 0.011 0.036 -10000 0 -0.17 15 15
IGHV3OR16-13 -0.005 0.008 -10000 0 -10000 0 0
TGIF2/HDAC complex -0.006 0.013 -10000 0 -0.31 1 1
CREBBP -0.007 0.044 -10000 0 -0.31 11 11
SKIL 0.14 0.12 0.24 330 -10000 0 330
HDAC1 0.009 0.06 0.24 36 -10000 0 36
HDAC2 -0.002 0.037 0.24 11 -0.31 1 12
SNIP1 -0.006 0.015 0.24 2 -10000 0 2
GCN5L2 -0.001 0.014 -10000 0 -10000 0 0
SMAD3/SMAD4/TFE3 0.005 0.071 0.34 9 -0.24 2 11
MSG1/HSC70 -0.004 0.027 0.17 13 -10000 0 13
SMAD2 -0.011 0.02 -10000 0 -0.31 2 2
SMAD3 -0.003 0.051 0.16 7 -0.38 2 9
SMAD3/E2F4-5/DP1/p107/SMAD4 0.024 0.06 0.21 19 -0.25 1 20
SMAD2/SMAD2/SMAD4 0.003 0.032 0.16 1 -10000 0 1
NCOR1 -0.007 0.018 -10000 0 -0.31 2 2
NCOA2 -0.005 0.015 0.24 2 -10000 0 2
NCOA1 -0.007 0.018 -10000 0 -0.31 2 2
MYOD/E2A -0.007 0 -10000 0 -10000 0 0
SMAD2-3/SMAD4/SP1/MIZ-1 0.028 0.094 0.28 10 -0.3 1 11
IFNB1 -0.001 0.055 -10000 0 -0.24 1 1
SMAD3/SMAD4/MEF2C -0.017 0.076 -10000 0 -0.34 15 15
CITED1 0 0.037 0.24 13 -10000 0 13
SMAD2-3/SMAD4/ARC105 -0.004 0.055 0.21 4 -0.24 1 5
RBL1 0.015 0.068 0.24 47 -10000 0 47
SMAD2-3/SMAD4/FOXO1-3a-4/CEBPB -0.006 0.04 -10000 0 -10000 0 0
RUNX1-3/PEBPB2 0.008 0.015 0.16 1 -0.18 3 4
SMAD7 0.018 0.13 0.41 16 -0.39 2 18
MYC/MIZ-1 -0.028 0.063 -10000 0 -0.21 59 59
SMAD3/SMAD4 0.064 0.1 0.33 40 -10000 0 40
IL10 -0.002 0.055 -10000 0 -10000 0 0
PIASy/HDAC complex -0.01 0.011 -10000 0 -10000 0 0
PIAS3 -0.003 0.013 0.24 1 -10000 0 1
CDK2 0.097 0.12 0.24 229 -10000 0 229
IL5 -0.002 0.055 -10000 0 -10000 0 0
CDK4 0.001 0.027 0.24 5 -10000 0 5
PIAS4 -0.01 0.011 -10000 0 -10000 0 0
ATF3 -0.002 0.033 0.24 9 -0.31 1 10
SMAD3/SMAD4/SP1 0.025 0.097 0.29 10 -0.27 5 15
FOXG1 -0.005 0.005 -10000 0 -10000 0 0
FOXO3 -0.01 0.026 0.2 1 -0.21 8 9
FOXO1 -0.009 0.023 0.2 1 -0.21 6 7
FOXO4 -0.007 0.009 0.2 1 -10000 0 1
heart looping -0.021 0.064 -10000 0 -0.33 20 20
CEBPB -0.008 0.027 0.24 1 -0.31 4 5
SMAD3/SMAD4/DLX1 -0.012 0.042 0.18 8 -0.24 2 10
MYOD1 -0.006 0 -10000 0 -10000 0 0
SMAD3/SMAD4/HNF4 -0.013 0.042 0.18 7 -0.24 2 9
SMAD3/SMAD4/GATA3 -0.009 0.049 0.18 10 -0.24 2 12
SnoN/SIN3/HDAC complex/NCoR1 0.14 0.12 0.24 330 -10000 0 330
SMAD3/SMAD4/RUNX1-3/PEBPB2 -0.002 0.053 0.2 7 -0.21 2 9
SMAD3/SMAD4/SP1-3 0.028 0.094 0.27 12 -0.32 1 13
MED15 -0.006 0.013 -10000 0 -0.31 1 1
SP1 0.021 0.053 0.16 10 -10000 0 10
SIN3B -0.006 0.01 0.24 1 -10000 0 1
SIN3A -0.006 0.001 -10000 0 -10000 0 0
SMAD2/SMAD2/SMAD4/FOXH1/NKX2-5 -0.009 0.048 -10000 0 -0.21 14 14
ITGB5 0.034 0.12 0.51 21 -0.29 1 22
TGIF/SIN3/HDAC complex/CtBP 0.006 0.036 0.21 2 -10000 0 2
SMAD3/SMAD4/AR -0.11 0.097 0.16 1 -0.21 219 220
AR -0.18 0.15 -10000 0 -0.31 329 329
negative regulation of cell growth 0.021 0.062 0.25 6 -0.28 3 9
SMAD3/SMAD4/MYOD -0.013 0.042 0.18 7 -0.24 2 9
E2F5 0.014 0.068 0.24 46 -10000 0 46
E2F4 -0.006 0 -10000 0 -10000 0 0
SMAD2/SMAD2/SMAD4/FOXH1/SMIF 0.001 0.041 -10000 0 -10000 0 0
SMAD2-3/SMAD4/FOXO1-3a-4 -0.007 0.041 -10000 0 -0.26 2 2
TFDP1 -0.001 0.034 0.24 11 -10000 0 11
SMAD3/SMAD4/AP1 -0.015 0.08 0.32 4 -0.28 7 11
SMAD3/SMAD4/RUNX2 -0.012 0.044 0.18 10 -0.24 2 12
TGIF2 -0.006 0.013 -10000 0 -0.31 1 1
TGIF1 -0.006 0 -10000 0 -10000 0 0
ATF2 -0.005 0.015 0.24 2 -10000 0 2
Wnt signaling

Figure S83.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S83.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Noncanonical Wnts/FZD 0.021 0.055 0.22 10 -0.18 5 15
FZD6 0.008 0.059 0.24 33 -0.31 1 34
WNT6 -0.006 0 -10000 0 -10000 0 0
WNT4 -0.006 0 -10000 0 -10000 0 0
FZD3 0.013 0.074 0.24 48 -0.31 4 52
WNT5A -0.003 0.025 0.24 6 -10000 0 6
WNT11 0.016 0.07 0.24 50 -10000 0 50
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha

Figure S84.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S84.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
HIF3A -0.004 0.021 0.24 4 -10000 0 4
oxygen homeostasis 0 0 -10000 0 -10000 0 0
TCEB2 -0.006 0 -10000 0 -10000 0 0
TCEB1 -0.006 0 -10000 0 -10000 0 0
HIF1A/p53 -0.003 0.027 -10000 0 -0.18 4 4
HIF1A -0.004 0.02 -10000 0 -10000 0 0
COPS5 0.014 0.068 0.24 46 -10000 0 46
VHL/Elongin B/Elongin C/RBX1/CUL2 0.039 0.054 0.28 1 -0.15 1 2
FIH (dimer) -0.006 0 -10000 0 -10000 0 0
CDKN2A 0.13 0.12 0.24 314 -10000 0 314
ARNT/IPAS -0.005 0.017 0.17 5 -10000 0 5
HIF1AN -0.006 0 -10000 0 -10000 0 0
GNB2L1 -0.006 0 -10000 0 -10000 0 0
HIF1A/ARNT -0.002 0.024 -10000 0 -10000 0 0
CUL2 0.042 0.1 0.24 112 -0.31 1 113
OS9 -0.005 0.01 0.24 1 -10000 0 1
RACK1/Elongin B/Elongin C 0.009 0 -10000 0 -10000 0 0
response to hypoxia 0 0 -10000 0 -10000 0 0
HIF1A/Hsp90 -0.002 0.023 -10000 0 -10000 0 0
PHD1-3/OS9 0.017 0.048 0.15 43 -0.16 16 59
HIF1A/RACK1/Elongin B/Elongin C -0.005 0.023 -10000 0 -10000 0 0
VHL -0.004 0.018 0.24 3 -10000 0 3
HSP90AA1 -0.006 0.013 -10000 0 -0.31 1 1
HIF1A/JAB1 0.01 0.05 0.2 14 -10000 0 14
EGLN3 0.004 0.084 0.24 42 -0.31 16 58
EGLN2 -0.006 0 -10000 0 -10000 0 0
EGLN1 -0.006 0 -10000 0 -10000 0 0
TP53 -0.051 0.11 0.24 1 -0.31 85 86
VHL/Elongin B/Elongin C/RBX1/CUL2/HIF1A 0.024 0.041 -10000 0 -10000 0 0
ARNT -0.005 0.01 0.24 1 -10000 0 1
ARD1A -0.001 0.033 0.24 10 -10000 0 10
RBX1 -0.006 0 -10000 0 -10000 0 0
HIF1A/p19ARF 0.08 0.078 0.2 25 -10000 0 25
Arf6 signaling events

Figure S85.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S85.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CENTA1/KIF3B -0.012 0.048 -10000 0 -0.17 47 47
ARNO/beta Arrestin1-2 -0.006 0.015 0.13 1 -0.13 7 8
EGFR -0.03 0.083 0.24 1 -0.31 46 47
EPHA2 -0.005 0.01 0.24 1 -10000 0 1
USP6 -0.006 0 -10000 0 -10000 0 0
IQSEC1 -0.006 0 -10000 0 -10000 0 0
EGFR/EGFR/EGF/EGF -0.021 0.061 0.2 7 -0.21 46 53
ARRB2 -0.001 0.009 0.16 2 -10000 0 2
mol:GTP 0.004 0.012 0.08 2 -10000 0 2
ARRB1 -0.009 0.035 0.24 1 -0.31 7 8
FBXO8 -0.006 0 -10000 0 -10000 0 0
TSHR 0.001 0.041 0.24 16 -10000 0 16
EGF -0.003 0.027 0.24 7 -10000 0 7
somatostatin receptor activity 0 0 0 1 -0.001 15 16
ARAP2 0 0 0 1 0 13 14
mol:GDP -0.013 0.051 -10000 0 -0.22 15 15
mol:PI-3-4-5-P3 0 0 0 1 -0.001 15 16
ITGA2B -0.006 0 -10000 0 -10000 0 0
ARF6 -0.006 0.013 -10000 0 -0.31 1 1
Ephrin A1/EPHA2/NCK1/GIT1 0.029 0.049 0.16 68 -10000 0 68
ADAP1 0 0 -10000 0 0 10 10
KIF13B -0.031 0.083 -10000 0 -0.31 47 47
HGF/MET 0.008 0.065 0.17 62 -0.21 12 74
PXN -0.01 0.033 -10000 0 -0.31 7 7
ARF6/GTP -0.017 0.054 0.13 1 -0.24 15 16
EGFR/EGFR/EGF/EGF/ARFGEP100 -0.006 0.053 0.16 6 -0.18 46 52
ADRB2 -0.006 0 -10000 0 -10000 0 0
receptor agonist activity 0 0 0 1 0 15 16
actin filament binding 0 0 -10000 0 0 15 15
SRC -0.006 0 -10000 0 -10000 0 0
ITGB3 -0.041 0.11 0.24 12 -0.31 77 89
GNAQ -0.012 0.043 -10000 0 -0.31 12 12
EFA6/PI-4-5-P2 0 0 0.001 3 -0.001 12 15
ARF6/GDP 0.003 0.032 0.11 1 -0.33 1 2
ARF6/GDP/GULP/ACAP1 -0.027 0.068 0.15 2 -0.21 28 30
alphaIIb/beta3 Integrin/paxillin/GIT1 -0.011 0.066 -10000 0 -0.16 81 81
ACAP1 0 0 0 1 -10000 0 1
ACAP2 0 0 0 1 0 13 14
LHCGR/beta Arrestin2 0.004 0.012 0.2 2 -10000 0 2
EFNA1 0.006 0.053 0.24 27 -10000 0 27
HGF -0.004 0.021 0.24 4 -10000 0 4
CYTH3 0 0 0 1 -0.001 15 16
CYTH2 0 0.001 -10000 0 -0.004 16 16
NCK1 0.012 0.065 0.24 42 -10000 0 42
fibronectin binding 0 0 -10000 0 0 13 13
endosomal lumen acidification 0 0 0 1 0 11 12
microtubule-based process 0 0 -10000 0 -10000 0 0
GULP1 -0.046 0.11 0.24 3 -0.31 78 81
GNAQ/ARNO 0.001 0.003 -10000 0 -10000 0 0
mol:Phosphatidic acid 0 0 0 1 0 13 14
PIP3-E -0.007 0.018 -10000 0 -0.31 2 2
MET 0.013 0.089 0.24 59 -0.31 12 71
GNA14 -0.005 0.015 0.24 2 -10000 0 2
GNA15 -0.006 0.016 0.24 1 -0.31 1 2
GIT1 -0.005 0.01 0.24 1 -10000 0 1
mol:PI-4-5-P2 0 0 0 1 -0.001 13 14
GNA11 -0.034 0.088 -10000 0 -0.31 53 53
LHCGR -0.005 0.015 0.24 2 -10000 0 2
AGTR1 -0.006 0 -10000 0 -10000 0 0
desensitization of G-protein coupled receptor protein signaling pathway 0.004 0.012 0.2 2 -10000 0 2
IPCEF1/ARNO -0.004 0.043 0.16 7 -0.13 48 55
alphaIIb/beta3 Integrin -0.031 0.076 0.17 12 -0.21 77 89
IFN-gamma pathway

Figure S86.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S86.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 -0.002 0.058 0.25 13 -0.17 13 26
positive regulation of NF-kappaB transcription factor activity 0 0.001 -10000 0 -10000 0 0
CRKL -0.006 0 -10000 0 -10000 0 0
STAT1 (dimer)/Cbp/p300 0.066 0.12 0.37 32 -0.23 9 41
IFN-gammaR/JAK1/JAK1/JAK2/JAK2 -0.01 0.038 0.14 1 -0.19 18 19
antigen processing and presentation of peptide antigen via MHC class I -0.034 0.069 0.17 2 -0.23 49 51
CaM/Ca2+ -0.011 0.046 0.26 4 -0.21 3 7
RAP1A -0.005 0.01 0.24 1 -10000 0 1
STAT1 (dimer)/SHP2 0.076 0.1 0.25 51 -0.26 1 52
AKT1 -0.014 0.09 0.22 15 -0.25 17 32
MAP2K1 -0.009 0.051 0.22 12 -0.23 2 14
MAP3K11 -0.006 0.051 0.23 12 -0.24 2 14
IFNGR1 -0.013 0.05 -10000 0 -0.31 15 15
mol:GTP 0 0 -10000 0 -10000 0 0
CaM/Ca2+/CAMKII -0.016 0.051 -10000 0 -0.35 8 8
Rap1/GTP -0.019 0.023 -10000 0 -0.2 2 2
CRKL/C3G -0.007 0 -10000 0 -10000 0 0
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 /TC-PTP 0.014 0.048 0.23 7 -0.16 18 25
CEBPB -0.011 0.077 0.35 5 -0.39 5 10
STAT3 -0.011 0.04 -10000 0 -0.31 10 10
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2/SOCS1 -0.026 0.15 0.34 1 -1 12 13
STAT1 0.077 0.1 0.25 53 -0.26 1 54
CALM1 -0.011 0.042 -10000 0 -0.31 11 11
IFN-gamma (dimer) 0.004 0.049 0.23 26 -10000 0 26
PIK3CA 0.048 0.1 0.24 122 -10000 0 122
STAT1 (dimer)/PIAS1 0.073 0.099 0.25 48 -0.25 1 49
CEBPB/PTGES2/Cbp/p300 -0.026 0.054 0.41 2 -0.3 6 8
mol:Ca2+ -0.006 0.047 0.28 4 -0.16 18 22
MAPK3 -0.019 0.12 0.32 3 -0.68 14 17
STAT1 (dimer) -0.033 0.12 0.41 16 -0.36 28 44
MAPK1 -0.003 0.063 0.31 4 -0.71 1 5
JAK2 -0.006 0.025 0.23 2 -0.32 2 4
PIK3R1 -0.075 0.13 -10000 0 -0.31 131 131
JAK1 -0.007 0.02 -10000 0 -0.31 2 2
CAMK2D -0.01 0.036 -10000 0 -0.31 8 8
DAPK1 -0.007 0.07 0.42 3 -0.54 3 6
SMAD7 0.016 0.081 0.3 21 -0.18 2 23
CBL/CRKL/C3G -0.012 0.038 -10000 0 -0.22 2 2
PI3K -0.019 0.083 0.16 3 -0.22 28 31
IFNG 0.004 0.049 0.23 26 -10000 0 26
apoptosis 0.004 0.066 0.37 5 -0.4 3 8
CAMK2G -0.005 0.002 -10000 0 -10000 0 0
STAT3 (dimer) -0.011 0.04 -10000 0 -0.31 10 10
CAMK2A -0.005 0.002 -10000 0 -10000 0 0
CAMK2B -0.005 0.002 -10000 0 -10000 0 0
FRAP1 -0.014 0.087 0.24 12 -0.24 16 28
PRKCD -0.014 0.092 0.22 17 -0.25 17 34
RAP1B -0.004 0.023 0.24 5 -10000 0 5
negative regulation of cell growth -0.034 0.069 0.17 2 -0.23 49 51
PTPN2 -0.005 0.002 -10000 0 -10000 0 0
EP300 -0.007 0.019 -10000 0 -0.31 2 2
IRF1 0.039 0.13 0.6 15 -0.32 13 28
STAT1 (dimer)/PIASy 0.075 0.1 0.28 40 -0.25 1 41
SOCS1 -0.025 0.17 -10000 0 -1.2 12 12
mol:GDP -0.014 0.032 -10000 0 -0.22 2 2
CASP1 0.011 0.12 0.45 21 -0.23 50 71
PTGES2 -0.006 0.001 -10000 0 -10000 0 0
IRF9 -0.007 0.047 0.25 10 -0.24 2 12
mol:PI-3-4-5-P3 -0.037 0.062 -10000 0 -0.16 97 97
RAP1/GDP -0.019 0.024 0.087 1 -0.2 2 3
CBL -0.006 0.051 0.22 13 -0.21 3 16
MAP3K1 -0.007 0.052 0.23 12 -0.24 2 14
PIAS1 -0.005 0.01 0.24 1 -10000 0 1
PIAS4 -0.005 0.003 -10000 0 -10000 0 0
antigen processing and presentation of peptide antigen via MHC class II -0.034 0.069 0.17 2 -0.23 49 51
PTPN11 -0.004 0.053 0.22 15 -0.16 18 33
CREBBP -0.011 0.042 -10000 0 -0.31 11 11
RAPGEF1 -0.006 0 -10000 0 -10000 0 0
a4b1 and a4b7 Integrin signaling

Figure S87.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S87.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
ITGB1 -0.003 0.025 0.24 6 -10000 0 6
ITGB7 -0.006 0.016 0.24 1 -0.31 1 2
ITGA4 0.007 0.055 0.24 30 -10000 0 30
alpha4/beta7 Integrin 0.002 0.043 0.18 30 -0.21 1 31
alpha4/beta1 Integrin 0.004 0.046 0.18 34 -10000 0 34
Signaling mediated by p38-alpha and p38-beta

Figure S88.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S88.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PTGS2 0.004 0.093 0.46 11 -0.88 3 14
MKNK1 -0.006 0 -10000 0 -10000 0 0
MAPK14 -0.003 0.039 0.19 11 -0.28 3 14
ATF2/c-Jun 0.005 0.075 0.43 14 -0.38 2 16
MAPK11 -0.003 0.038 0.18 10 -0.28 3 13
MITF 0.001 0.043 0.21 10 -0.33 3 13
MAPKAPK5 0.001 0.043 0.21 10 -0.33 3 13
KRT8 0.002 0.046 0.21 10 -0.31 4 14
MAPKAPK3 -0.006 0 -10000 0 -10000 0 0
MAPKAPK2 -0.006 0 -10000 0 -10000 0 0
p38alpha-beta/CK2 -0.003 0.052 0.25 10 -0.4 3 13
CEBPB 0 0.048 0.21 10 -0.28 7 17
SLC9A1 0.001 0.043 0.21 10 -0.33 3 13
mol:GDP 0 0 -10000 0 -10000 0 0
ATF2 0.005 0.06 0.26 24 -0.33 3 27
p38alpha-beta/MNK1 -0.004 0.044 0.22 10 -0.32 3 13
JUN 0.005 0.076 0.44 14 -0.38 2 16
PPARGC1A 0.003 0.047 0.21 10 -0.33 3 13
USF1 0.002 0.045 0.21 10 -0.33 3 13
RAB5/GDP/GDI1 -0.005 0.024 -10000 0 -0.22 5 5
NOS2 0.002 0.043 0.21 10 -0.33 3 13
DDIT3 0.02 0.071 0.27 11 -0.33 3 14
RAB5A -0.006 0 -10000 0 -10000 0 0
HSPB1 -0.005 0.039 -10000 0 -0.27 3 3
p38alpha-beta/HBP1 0.002 0.053 0.22 10 -0.32 3 13
CREB1 0.004 0.044 0.21 10 -0.36 3 13
RAB5/GDP -0.003 0 -10000 0 -10000 0 0
EIF4E -0.007 0.033 -10000 0 -0.28 3 3
RPS6KA4 0.001 0.043 0.21 10 -0.33 3 13
PLA2G4A -0.088 0.092 0.19 5 -0.17 288 293
GDI1 0.001 0.046 0.21 10 -0.3 5 15
TP53 -0.001 0.05 0.23 9 -0.45 3 12
RPS6KA5 0.001 0.043 0.21 10 -0.33 3 13
ESR1 -0.029 0.09 0.21 8 -0.24 76 84
HBP1 0.003 0.046 0.24 20 -10000 0 20
MEF2C -0.007 0.065 0.21 10 -0.27 21 31
MEF2A 0.001 0.043 0.21 10 -0.33 3 13
EIF4EBP1 0.004 0.044 0.21 10 -0.36 3 13
KRT19 -0.01 0.067 0.21 10 -0.25 30 40
ELK4 0.001 0.043 0.21 10 -0.33 3 13
ATF6 0.001 0.043 0.21 10 -0.33 3 13
ATF1 0.004 0.044 0.21 10 -0.36 3 13
p38alpha-beta/MAPKAPK2 -0.004 0.044 0.22 10 -0.32 3 13
p38alpha-beta/MAPKAPK3 -0.004 0.044 0.22 10 -0.32 3 13
TCR signaling in naïve CD8+ T cells

Figure S89.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S89.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
GRB2/SOS1/SHC -0.019 0.071 0.18 3 -0.32 12 15
FYN -0.038 0.11 0.3 10 -0.36 32 42
LAT/GRAP2/SLP76 -0.029 0.073 -10000 0 -0.34 16 16
IKBKB -0.005 0.015 0.24 2 -10000 0 2
AKT1 -0.019 0.078 0.24 10 -0.31 16 26
B2M -0.008 0.032 -10000 0 -0.31 6 6
IKBKG -0.01 0.024 -10000 0 -0.1 10 10
MAP3K8 -0.006 0 -10000 0 -10000 0 0
mol:Ca2+ -0.01 0.008 -10000 0 -0.042 11 11
integrin-mediated signaling pathway 0.006 0.006 0.15 1 -10000 0 1
LAT/GRAP2/SLP76/VAV1/PI3K Class IA -0.025 0.1 0.27 10 -0.42 16 26
TRPV6 0.003 0.027 0.48 1 -10000 0 1
CD28 -0.005 0.004 -10000 0 -10000 0 0
SHC1 -0.019 0.087 0.3 7 -0.38 12 19
receptor internalization -0.015 0.078 0.28 7 -0.33 12 19
PRF1 -0.034 0.17 0.67 1 -1 14 15
KRAS 0.025 0.082 0.24 71 -10000 0 71
GRB2 -0.006 0 -10000 0 -10000 0 0
COT/AKT1 -0.017 0.065 0.21 10 -0.25 16 26
LAT -0.019 0.086 0.3 7 -0.38 12 19
EntrezGene:6955 -0.001 0.004 0.051 1 -10000 0 1
CD3D -0.035 0.096 0.25 3 -0.31 59 62
CD3E -0.004 0.037 0.25 7 -0.32 3 10
CD3G 0.01 0.061 0.24 37 -10000 0 37
RASGRP2 -0.003 0.009 0.064 1 -10000 0 1
RASGRP1 -0.049 0.12 0.26 7 -0.29 82 89
HLA-A -0.007 0.019 -10000 0 -0.32 2 2
RASSF5 -0.006 0 -10000 0 -10000 0 0
RAP1A/GTP/RAPL 0.006 0.006 0.15 1 -10000 0 1
mol:GTP 0 0 -10000 0 -10000 0 0
mol:GDP -0.009 0.039 0.12 11 -0.1 25 36
PDK1/CARD11/BCL10/MALT1/TRAF6 -0.02 0.032 -10000 0 -0.16 15 15
PRKCA -0.018 0.042 0.11 5 -0.18 17 22
GRAP2 -0.006 0 -10000 0 -10000 0 0
mol:IP3 -0.026 0.055 -10000 0 -0.27 15 15
EntrezGene:6957 -0.001 0.004 0.058 1 -10000 0 1
TCR/CD3/MHC I/CD8 -0.016 0.076 0.26 7 -0.34 12 19
ORAI1 -0.015 0.049 -10000 0 -0.38 1 1
CSK -0.02 0.086 0.3 7 -0.39 12 19
B7 family/CD28 -0.021 0.1 0.37 10 -0.38 18 28
CHUK 0.002 0.043 0.24 18 -10000 0 18
TCR/CD3/MHC I/CD8/LCK/ZAP-70 -0.022 0.091 0.31 7 -0.42 12 19
PTPN6 -0.02 0.09 0.27 10 -0.4 12 22
VAV1 -0.019 0.087 0.3 7 -0.38 12 19
Monovalent TCR/CD3 -0.015 0.076 0.29 7 -0.2 56 63
CBL -0.006 0 -10000 0 -10000 0 0
LCK -0.022 0.1 0.29 10 -0.37 23 33
PAG1 -0.019 0.086 0.3 7 -0.39 12 19
RAP1A -0.005 0.01 0.24 1 -10000 0 1
TCR/CD3/MHC I/CD8/LCK -0.022 0.092 0.32 7 -0.43 12 19
CD80 -0.001 0.034 0.24 11 -10000 0 11
CD86 0.002 0.043 0.24 18 -10000 0 18
PDK1/CARD11/BCL10/MALT1 -0.021 0.039 -10000 0 -0.19 15 15
HRAS -0.006 0 -10000 0 -10000 0 0
GO:0035030 -0.019 0.09 0.32 11 -0.33 18 29
CD8A -0.005 0.006 -10000 0 -10000 0 0
CD8B -0.004 0.018 0.23 3 -10000 0 3
PTPRC -0.005 0.11 0.24 53 -0.31 41 94
PDK1/PKC theta -0.025 0.088 0.26 10 -0.36 16 26
CSK/PAG1 -0.021 0.083 0.28 7 -0.38 12 19
SOS1 0.005 0.05 0.24 24 -10000 0 24
peptide-MHC class I -0.009 0.027 -10000 0 -0.22 8 8
GRAP2/SLP76 -0.029 0.082 -10000 0 -0.39 16 16
STIM1 -0.02 0.07 -10000 0 -0.3 32 32
RAS family/GTP 0.031 0.064 0.15 58 -0.14 5 63
TCR/CD3/MHC I/CD8/LCK/ZAP-70/CBL/ubiquitin -0.016 0.08 0.28 7 -0.35 12 19
mol:DAG -0.026 0.049 -10000 0 -0.25 15 15
RAP1A/GDP -0.005 0.018 0.071 5 -0.052 10 15
PLCG1 -0.004 0.023 0.24 5 -10000 0 5
CD247 -0.006 0.005 -10000 0 -10000 0 0
cytotoxic T cell degranulation -0.032 0.16 0.67 1 -0.96 14 15
RAP1A/GTP -0.002 0.003 -10000 0 -10000 0 0
mol:PI-3-4-5-P3 -0.021 0.088 0.26 10 -0.36 16 26
LAT/GRAP2/SLP76/VAV1/PLCgamma1 -0.031 0.067 -10000 0 -0.33 15 15
NRAS 0.12 0.12 0.24 300 -10000 0 300
ZAP70 -0.006 0.002 -10000 0 -10000 0 0
GRB2/SOS1 0.001 0.036 0.17 24 -10000 0 24
LAT/GRAP2/SLP76/VAV1 -0.032 0.067 -10000 0 -0.33 16 16
MALT1 0.011 0.062 0.24 38 -10000 0 38
TRAF6 -0.005 0.015 0.24 2 -10000 0 2
CD8 heterodimer -0.005 0.014 0.17 2 -10000 0 2
CARD11 -0.005 0.01 0.24 1 -10000 0 1
PRKCB -0.02 0.035 -10000 0 -0.18 15 15
PRKCE -0.019 0.038 -10000 0 -0.18 15 15
PRKCQ -0.026 0.095 0.26 10 -0.39 17 27
LCP2 -0.015 0.053 -10000 0 -0.31 18 18
BCL10 -0.006 0 -10000 0 -10000 0 0
regulation of survival gene product expression -0.016 0.07 0.23 10 -0.27 16 26
IKK complex -0.003 0.027 0.14 7 -0.1 3 10
RAS family/GDP -0.002 0.006 -10000 0 -10000 0 0
MAP3K14 -0.015 0.053 0.2 8 -0.2 16 24
PDPK1 -0.019 0.075 0.24 10 -0.3 16 26
TCR/CD3/MHC I/CD8/Fyn -0.023 0.094 0.3 7 -0.42 14 21
Presenilin action in Notch and Wnt signaling

Figure S90.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S90.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Delta 1/NOTCH/NOTCH(cleaved) -0.01 0.078 -10000 0 -0.5 13 13
HDAC1 0.025 0.064 0.26 36 -10000 0 36
AES -0.046 0.11 -10000 0 -0.3 89 89
FBXW11 -0.006 0 -10000 0 -10000 0 0
DTX1 -0.006 0 -10000 0 -10000 0 0
LRP6/FZD1 0.005 0.046 0.17 41 -10000 0 41
TLE1 0.002 0.03 0.25 6 -0.3 1 7
AP1 -0.017 0.08 0.23 6 -0.2 70 76
NCSTN -0.006 0.01 0.24 1 -10000 0 1
ADAM10 -0.001 0.015 0.24 2 -10000 0 2
Beta Catenin/TCF1/CtBP/CBP/TLE1/AES/SMAD4 -0.12 0.17 -10000 0 -0.52 46 46
NICD/RBPSUH -0.011 0.078 -10000 0 -0.5 13 13
WIF1 -0.002 0.033 0.24 10 -10000 0 10
NOTCH1 -0.014 0.081 -10000 0 -0.53 13 13
PSENEN -0.016 0.054 -10000 0 -0.31 19 19
KREMEN2 -0.006 0 -10000 0 -10000 0 0
DKK1 0.002 0.043 0.24 18 -10000 0 18
beta catenin/beta TrCP1 -0.025 0.037 -10000 0 -10000 0 0
APH1B -0.039 0.093 -10000 0 -0.31 61 61
APH1A -0.006 0.01 0.24 1 -10000 0 1
AXIN1 -0.004 0.027 -10000 0 -10000 0 0
CtBP/CBP/TCF1/TLE1/AES 0.023 0.099 0.25 32 -10000 0 32
PSEN1 -0.006 0.01 0.24 1 -10000 0 1
FOS -0.029 0.11 0.24 26 -0.31 65 91
JUN -0.001 0.042 0.24 14 -0.31 2 16
MAP3K7 0.005 0.027 0.24 6 -10000 0 6
CTNNB1 -0.024 0.038 -10000 0 -10000 0 0
MAPK3 -0.013 0.047 -10000 0 -0.31 14 14
DKK2/LRP6/Kremen 2 0.014 0.04 0.16 41 -10000 0 41
HNF1A 0.002 0.012 -10000 0 -10000 0 0
CTBP1 0.002 0.012 -10000 0 -10000 0 0
MYC -0.14 0.36 -10000 0 -1.2 59 59
NKD1 -0.001 0.012 0.24 1 -10000 0 1
FZD1 -0.006 0.001 -10000 0 -10000 0 0
NOTCH1 precursor/Deltex homolog 1 -0.012 0.077 -10000 0 -0.5 13 13
apoptosis -0.017 0.08 0.23 6 -0.2 70 76
Delta 1/NOTCHprecursor -0.012 0.077 -10000 0 -0.5 13 13
DLL1 -0.006 0 -10000 0 -10000 0 0
PPARD -0.03 0.042 -10000 0 -10000 0 0
Gamma Secretase -0.019 0.058 -10000 0 -0.16 79 79
APC -0.004 0.027 -10000 0 -10000 0 0
DVL1 -0.006 0.011 -10000 0 -10000 0 0
CSNK2A1 -0.007 0.002 -10000 0 -10000 0 0
MAP3K7IP1 0.003 0.012 -10000 0 -10000 0 0
DKK1/LRP6/Kremen 2 0.018 0.047 0.16 57 -10000 0 57
LRP6 0.012 0.064 0.24 41 -10000 0 41
CSNK1A1 -0.006 0.015 0.24 2 -10000 0 2
NLK 0.013 0.027 0.19 1 -10000 0 1
CCND1 -0.32 0.52 0.52 1 -1.2 150 151
WNT1 -0.006 0.001 -10000 0 -10000 0 0
Axin1/APC/beta catenin -0.027 0.041 -10000 0 -10000 0 0
DKK2 -0.006 0 -10000 0 -10000 0 0
NOTCH1 precursor/DVL1 -0.017 0.071 -10000 0 -0.46 13 13
GSK3B -0.001 0.006 -10000 0 -10000 0 0
FRAT1 -0.001 0.015 -10000 0 -0.31 1 1
NOTCH/Deltex homolog 1 -0.01 0.078 -10000 0 -0.5 13 13
PPP2R5D -0.003 0.01 -10000 0 -10000 0 0
MAPK1 -0.006 0.016 0.24 1 -0.31 1 2
WNT1/LRP6/FZD1 0.016 0.046 0.29 3 -10000 0 3
RBPJ -0.005 0.01 0.24 1 -10000 0 1
CREBBP -0.009 0.04 -10000 0 -0.3 11 11
Atypical NF-kappaB pathway

Figure S91.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S91.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BCL3/RelA -0.008 0.02 -10000 0 -0.27 3 3
FBXW11 -0.006 0 -10000 0 -10000 0 0
NF kappa B1 p50/c-Rel -0.01 0.021 0.14 2 -0.18 7 9
NF kappa B1 p50/RelA/I kappa B alpha -0.014 0.033 -10000 0 -0.28 2 2
NFKBIA -0.007 0.029 -10000 0 -0.17 18 18
MAPK14 -0.005 0.01 0.24 1 -10000 0 1
NF kappa B1 p105/p50 -0.01 0.021 0.14 2 -0.18 7 9
ARRB2 -0.002 0.007 0.16 1 -10000 0 1
REL -0.006 0 -10000 0 -10000 0 0
response to oxidative stress 0 0 -10000 0 -10000 0 0
BCL3/NF kappa B1 p50 -0.011 0.024 0.14 2 -0.18 10 12
response to UV 0 0 -10000 0 -10000 0 0
NF kappa B1 p105/RelA -0.01 0.022 0.14 2 -0.18 8 10
PIK3CA 0.047 0.1 0.24 122 -10000 0 122
NF kappa B1 p50 dimer -0.009 0.026 0.2 2 -0.21 7 9
PIK3R1 -0.075 0.13 -10000 0 -0.31 131 131
NFKB1 -0.009 0.026 0.2 2 -0.21 7 9
RELA -0.006 0.013 -10000 0 -0.31 1 1
positive regulation of anti-apoptosis -0.006 0.022 -10000 0 -0.16 7 7
NF kappa B1 p50/RelA/I kappa B alpha/beta Arrestin2 -0.014 0.032 -10000 0 -0.27 2 2
SRC -0.006 0 -10000 0 -10000 0 0
PI3K -0.015 0.12 0.17 98 -0.21 107 205
NF kappa B1 p50/RelA -0.006 0.022 -10000 0 -0.16 7 7
IKBKB -0.005 0.015 0.24 2 -10000 0 2
beta TrCP1/SCF ubiquitin ligase complex -0.006 0 -10000 0 -10000 0 0
SYK -0.008 0.034 0.24 2 -0.31 6 8
I kappa B alpha/PIK3R1 -0.01 0.038 -10000 0 -0.2 19 19
cell death -0.014 0.031 -10000 0 -0.26 2 2
NF kappa B1 p105/c-Rel -0.01 0.021 0.14 2 -0.18 7 9
LCK -0.006 0 -10000 0 -10000 0 0
BCL3 -0.007 0.022 -10000 0 -0.31 3 3
HIV-1 Nef: Negative effector of Fas and TNF-alpha

Figure S92.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S92.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BAG4 -0.006 0 -10000 0 -10000 0 0
Caspase 8 (4 units) -0.013 0.036 -10000 0 -0.38 1 1
NEF -0.002 0 -10000 0 -10000 0 0
NFKBIA -0.023 0.06 -10000 0 -0.35 13 13
BIRC3 -0.059 0.16 0.45 16 -0.38 90 106
CYCS -0.013 0.036 -10000 0 -0.37 1 1
RIPK1 -0.006 0 -10000 0 -10000 0 0
CD247 -0.008 0 -10000 0 -10000 0 0
MAP2K7 -0.01 0.043 -10000 0 -0.46 1 1
protein ubiquitination -0.019 0.061 0.18 1 -0.22 19 20
CRADD -0.006 0 -10000 0 -10000 0 0
DAXX -0.005 0.015 0.24 2 -10000 0 2
FAS -0.017 0.058 0.24 1 -0.31 21 22
BID -0.012 0.036 -10000 0 -0.38 1 1
NF-kappa-B/RelA/I kappa B alpha -0.049 0.088 -10000 0 -0.24 95 95
TRADD -0.01 0.036 -10000 0 -0.31 8 8
MAP3K5 -0.006 0.023 0.24 2 -0.31 2 4
CFLAR -0.006 0 -10000 0 -10000 0 0
FADD -0.006 0 -10000 0 -10000 0 0
NF-kappa-B/RelA/I kappa B alpha/ubiquitin -0.049 0.088 -10000 0 -0.24 95 95
MAPK8 -0.011 0.039 -10000 0 -0.44 1 1
APAF1 0.002 0.042 0.24 17 -10000 0 17
TRAF1 -0.006 0 -10000 0 -10000 0 0
TRAF2 -0.006 0 -10000 0 -10000 0 0
FAS/FADD/DAXX/Ask1/Caspase 8/Caspase 8/FASLG -0.011 0.038 -10000 0 -0.4 1 1
TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP1/cIAP2/TRAF1/TRAF2/Ask1/RAIDD -0.024 0.07 -10000 0 -0.27 20 20
CHUK -0.021 0.065 0.18 1 -0.24 19 20
FAS/FADD/DAXX/Ask1/Caspase 8/Caspase 8 0.007 0.036 -10000 0 -0.16 22 22
TCRz/NEF -0.007 0 -10000 0 -10000 0 0
TNF -0.005 0.01 0.24 1 -10000 0 1
FASLG -0.007 0 -10000 0 -10000 0 0
NFKB1 -0.02 0.052 -10000 0 -0.37 7 7
TNFR1A/BAG4/TNF-alpha 0.003 0.034 0.16 1 -0.18 19 20
CASP6 0.024 0.075 -10000 0 -0.33 1 1
CASP7 -0.07 0.17 0.33 15 -0.44 90 105
RELA -0.016 0.037 -10000 0 -0.38 1 1
CASP2 0.001 0.041 0.24 16 -10000 0 16
CASP3 -0.069 0.17 0.33 15 -0.44 90 105
TNFRSF1A -0.016 0.054 -10000 0 -0.31 19 19
TNFR1A/BAG4 -0.014 0.037 -10000 0 -0.21 19 19
CASP8 -0.006 0 -10000 0 -10000 0 0
CASP9 -0.005 0.01 0.24 1 -10000 0 1
MAP3K14 -0.024 0.066 -10000 0 -0.26 20 20
APAF-1/Caspase 9 -0.057 0.1 -10000 0 -0.28 88 88
BCL2 -0.032 0.058 -10000 0 -0.33 4 4
Signaling events mediated by Stem cell factor receptor (c-Kit)

Figure S93.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S93.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
MAP4K1 -0.012 0.1 0.32 18 -10000 0 18
CRKL -0.011 0.11 0.33 18 -0.26 2 20
HRAS -0.007 0.097 0.29 18 -10000 0 18
mol:PIP3 -0.006 0.11 0.32 17 -0.26 7 24
SPRED1 -0.008 0.03 0.24 1 -0.31 5 6
SPRED2 -0.006 0 -10000 0 -10000 0 0
GAB1 -0.009 0.11 0.35 18 -0.28 2 20
FOXO3 -0.009 0.1 0.31 18 -0.32 1 19
AKT1 -0.006 0.11 0.32 18 -10000 0 18
BAD -0.007 0.1 0.31 18 -10000 0 18
megakaryocyte differentiation -0.008 0.11 0.36 18 -0.27 2 20
GSK3B -0.007 0.1 0.31 18 -10000 0 18
RAF1 -0.007 0.085 0.27 18 -10000 0 18
SHC1 -0.006 0 -10000 0 -10000 0 0
STAT3 -0.011 0.11 0.35 16 -0.28 3 19
STAT1 -0.014 0.22 0.54 10 -0.54 30 40
HRAS/SPRED1 -0.006 0.086 0.26 18 -0.27 3 21
cell proliferation -0.007 0.11 0.36 18 -0.27 2 20
PIK3CA 0.047 0.1 0.24 122 -10000 0 122
TEC 0.013 0.066 0.24 44 -10000 0 44
RPS6KB1 -0.004 0.11 0.34 18 -10000 0 18
HRAS/SPRED2 -0.006 0.085 0.26 18 -10000 0 18
LYN/TEC/p62DOK -0.007 0.1 0.49 2 -0.29 3 5
MAPK3 -0.019 0.072 0.23 12 -0.24 3 15
STAP1 -0.008 0.11 0.35 18 -0.28 2 20
GRAP2 -0.006 0 -10000 0 -10000 0 0
JAK2 -0.025 0.2 0.5 10 -10000 0 10
STAT1 (dimer) -0.014 0.22 0.54 10 -0.54 30 40
mol:Gleevec 0.001 0.008 -10000 0 -10000 0 0
GRB2/SOCS1/VAV1 -0.016 0.093 -10000 0 -0.29 3 3
actin filament polymerization -0.006 0.11 0.35 18 -0.27 2 20
LYN -0.014 0.048 -10000 0 -0.31 15 15
STAP1/STAT5A (dimer) -0.019 0.15 0.39 17 -0.52 3 20
PIK3R1 -0.074 0.13 -10000 0 -0.31 131 131
CBL/CRKL/GRB2 -0.012 0.098 0.28 16 -10000 0 16
PI3K -0.015 0.12 0.28 5 -0.34 17 22
PTEN -0.012 0.042 -10000 0 -0.31 11 11
SCF/KIT/EPO/EPOR -0.021 0.2 0.6 2 -10000 0 2
MAPK8 -0.007 0.12 0.36 18 -0.28 2 20
STAT3 (dimer) -0.011 0.11 0.35 16 -0.27 3 19
positive regulation of transcription -0.014 0.063 0.22 12 -0.19 3 15
mol:GDP -0.008 0.1 0.29 18 -0.29 1 19
PIK3C2B -0.008 0.12 0.36 18 -0.28 2 20
CBL/CRKL -0.011 0.1 0.31 18 -0.26 1 19
FER -0.009 0.11 0.35 18 -0.28 1 19
SH2B3 -0.009 0.11 0.35 18 -0.28 2 20
PDPK1 -0.008 0.1 0.3 17 -0.26 7 24
SNAI2 -0.011 0.12 0.34 19 -0.33 7 26
positive regulation of cell proliferation -0.017 0.18 0.44 16 -0.5 3 19
KITLG 0.002 0.029 0.23 5 -10000 0 5
cell motility -0.017 0.18 0.44 16 -0.5 3 19
PTPN6 -0.003 0.014 -10000 0 -10000 0 0
EPOR -0.021 0.14 0.78 1 -0.64 8 9
STAT5A (dimer) -0.018 0.16 0.41 17 -0.53 3 20
SOCS1 -0.012 0.043 -10000 0 -0.31 12 12
cell migration 0.008 0.11 0.27 2 -0.34 18 20
SOS1 0.005 0.05 0.24 24 -10000 0 24
EPO 0 0.014 -10000 0 -10000 0 0
VAV1 -0.004 0.021 0.24 4 -10000 0 4
GRB10 -0.009 0.11 0.35 18 -0.28 2 20
PTPN11 -0.003 0.011 -10000 0 -10000 0 0
SCF/KIT -0.006 0.12 0.38 18 -0.29 2 20
GO:0007205 0 0.01 -10000 0 -10000 0 0
MAP2K1 -0.006 0.073 0.24 18 -10000 0 18
CBL -0.006 0 -10000 0 -10000 0 0
KIT -0.011 0.16 0.54 18 -0.57 8 26
MAP2K2 -0.024 0.081 0.24 14 -0.24 16 30
SHC/Grb2/SOS1 -0.009 0.093 -10000 0 -0.26 2 2
STAT5A -0.018 0.16 0.41 17 -0.55 3 20
GRB2 -0.006 0 -10000 0 -10000 0 0
response to radiation -0.01 0.12 0.34 19 -0.32 7 26
SHC/GRAP2 -0.007 0 -10000 0 -10000 0 0
PTPRO -0.008 0.12 0.36 18 -0.28 2 20
SH2B2 -0.007 0.11 0.35 18 -0.27 2 20
DOK1 -0.007 0.018 -10000 0 -0.31 2 2
MATK -0.009 0.11 0.35 18 -0.28 2 20
CREBBP -0.013 0.077 0.26 18 -0.32 11 29
BCL2 -0.16 0.43 0.79 1 -1.1 102 103
FOXA2 and FOXA3 transcription factor networks

Figure S94.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S94.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
ACADVL 0.097 0.22 0.55 14 -10000 0 14
PCK1 0.15 0.21 0.56 58 -10000 0 58
HNF4A 0.13 0.26 0.67 18 -10000 0 18
KCNJ11 0.1 0.24 0.58 10 -10000 0 10
AKT1 0.072 0.15 0.36 26 -10000 0 26
response to starvation 0.015 0.029 0.14 2 -10000 0 2
DLK1 0.12 0.26 0.71 20 -10000 0 20
NKX2-1 0.073 0.15 -10000 0 -10000 0 0
ACADM 0.1 0.23 0.55 19 -10000 0 19
TAT 0.1 0.17 0.51 11 -10000 0 11
CEBPB -0.007 0.028 0.19 2 -0.31 4 6
CEBPA -0.006 0.008 0.13 1 -10000 0 1
TTR 0.092 0.14 0.99 2 -10000 0 2
PKLR 0.096 0.22 0.56 8 -10000 0 8
APOA1 0.16 0.31 0.77 44 -10000 0 44
CPT1C 0.1 0.23 0.59 19 -10000 0 19
ALAS1 0.067 0.16 0.78 2 -10000 0 2
TFRC 0.21 0.3 0.64 140 -10000 0 140
FOXF1 -0.006 0 -10000 0 -10000 0 0
NF1 -0.019 0.065 0.18 4 -0.31 26 30
HNF1A (dimer) -0.007 0.009 -10000 0 -0.22 1 1
CPT1A 0.095 0.22 0.56 8 -0.94 1 9
HMGCS1 0.12 0.25 0.59 46 -10000 0 46
NR3C1 -0.012 0.04 -10000 0 -0.31 10 10
CPT1B 0.096 0.22 0.55 11 -10000 0 11
chromatin remodeling 0 0 -10000 0 -10000 0 0
SP1 -0.007 0.009 -10000 0 -0.22 1 1
GCK 0.096 0.22 0.54 13 -10000 0 13
CREB1 0.027 0.07 0.18 91 -10000 0 91
IGFBP1 0.073 0.15 0.49 2 -10000 0 2
PDX1 0.07 0.16 -10000 0 -1 1 1
UCP2 -0.007 0.37 0.54 12 -0.74 75 87
ALDOB 0.1 0.24 0.58 11 -10000 0 11
AFP 0.037 0.053 0.56 1 -10000 0 1
BDH1 0.095 0.23 0.56 12 -0.77 1 13
HADH 0.083 0.27 0.58 11 -0.88 6 17
F2 0.13 0.27 0.72 13 -10000 0 13
HNF1A -0.007 0.009 -10000 0 -0.22 1 1
G6PC 0.038 0.062 -10000 0 -10000 0 0
SLC2A2 0.082 0.18 0.52 2 -10000 0 2
INS -0.005 0.015 -10000 0 -0.19 2 2
FOXA1 -0.006 0.025 0.36 2 -10000 0 2
FOXA3 0.091 0.12 0.37 34 -10000 0 34
FOXA2 0.15 0.32 0.79 29 -10000 0 29
ABCC8 0.1 0.24 0.58 10 -10000 0 10
ALB 0.037 0.055 0.49 2 -10000 0 2
Ceramide signaling pathway

Figure S95.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S95.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
SPHK2 -0.011 0.029 -10000 0 -0.21 12 12
MAP4K4 -0.033 0.074 -10000 0 -0.33 12 12
BAG4 -0.006 0 -10000 0 -10000 0 0
PKC zeta/ceramide 0.007 0.012 0.12 1 -10000 0 1
NFKBIA -0.013 0.045 -10000 0 -0.31 13 13
BIRC3 -0.047 0.12 0.24 16 -0.31 90 106
BAX 0.004 0.007 -10000 0 -10000 0 0
RIPK1 -0.006 0 -10000 0 -10000 0 0
AKT1 -0.005 0.016 0.37 1 -10000 0 1
BAD 0.003 0.013 0.13 1 -10000 0 1
SMPD1 -0.014 0.033 -10000 0 -0.17 11 11
RB1 0.006 0.031 0.14 22 -0.14 4 26
FADD/Caspase 8 -0.034 0.076 -10000 0 -0.33 15 15
MAP2K4 -0.002 0.021 0.12 1 -0.14 9 10
NSMAF -0.004 0.023 0.24 5 -10000 0 5
response to UV 0 0 -10000 0 -10000 0 0
RAF1 0 0.013 0.12 1 -10000 0 1
EGF -0.003 0.027 0.24 7 -10000 0 7
mol:ceramide 0.005 0.014 0.097 12 -10000 0 12
MADD -0.006 0 -10000 0 -10000 0 0
response to oxidative stress 0 0 -10000 0 -10000 0 0
mol:Free Fatty acid -0.011 0.029 -10000 0 -0.21 12 12
ASAH1 -0.006 0 -10000 0 -10000 0 0
negative regulation of cell cycle 0.006 0.031 0.14 22 -0.14 4 26
cell proliferation -0.022 0.043 0.12 3 -0.2 13 16
BID -0.018 0.058 -10000 0 -0.35 3 3
MAP3K1 0.002 0.017 0.13 1 -0.14 3 4
EIF2A 0.045 0.06 0.12 226 -10000 0 226
TRADD -0.01 0.036 -10000 0 -0.31 8 8
CRADD -0.006 0 -10000 0 -10000 0 0
MAPK3 -0.017 0.037 0.11 1 -0.16 12 13
response to heat 0 0 -10000 0 -10000 0 0
MAPK1 -0.014 0.03 0.11 1 -10000 0 1
Cathepsin D/ceramide 0.007 0.012 0.12 1 -10000 0 1
FADD -0.034 0.074 -10000 0 -0.33 12 12
KSR1 0.003 0.013 0.13 1 -10000 0 1
MAPK8 0.002 0.018 -10000 0 -10000 0 0
PRKRA 0.003 0.016 0.13 4 -10000 0 4
PDGFA -0.012 0.043 -10000 0 -0.31 12 12
TRAF2 -0.006 0 -10000 0 -10000 0 0
IGF1 -0.016 0.06 0.24 3 -0.31 21 24
mol:GD3 0 0 -10000 0 -10000 0 0
ganglioside biosynthetic process 0.005 0.014 0.097 12 -10000 0 12
CTSD -0.008 0.025 -10000 0 -0.31 4 4
regulation of nitric oxide biosynthetic process -0.01 0.024 -10000 0 -0.21 8 8
response to radiation 0 0 -10000 0 -10000 0 0
ERK1/PKC delta -0.023 0.046 0.14 3 -0.21 13 16
PRKCD -0.006 0.021 0.24 1 -0.31 2 3
PRKCZ -0.006 0 -10000 0 -10000 0 0
mol:GW4869 0 0 -10000 0 -10000 0 0
mol:sphingosine -0.011 0.029 -10000 0 -0.21 12 12
RelA/NF kappa B1 -0.01 0.024 -10000 0 -0.21 8 8
mol:glutathione 0 0 -10000 0 -10000 0 0
PAWR -0.006 0 -10000 0 -10000 0 0
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP1/TRAF2/RAIDD -0.034 0.079 -10000 0 -0.35 12 12
TNFR1A/BAG4/TNF-alpha 0.003 0.034 0.16 1 -0.18 19 20
mol:Sphingosine-1-phosphate -0.011 0.029 -10000 0 -0.21 12 12
MAP2K1 -0.001 0.013 0.11 2 -10000 0 2
mol:C11AG 0 0 -10000 0 -10000 0 0
RELA -0.006 0.013 -10000 0 -0.31 1 1
CYCS 0.023 0.048 0.13 93 -10000 0 93
TNFRSF1A -0.016 0.054 -10000 0 -0.31 19 19
NFKB1 -0.01 0.033 -10000 0 -0.31 7 7
TNFR1A/BAG4 -0.014 0.037 -10000 0 -0.21 19 19
EIF2AK2 0.048 0.063 0.12 222 -10000 0 222
TNF-alpha/TNFR1A/FAN 0.004 0.037 0.16 6 -0.18 19 25
response to hydrogen peroxide 0 0 -10000 0 -10000 0 0
CASP8 -0.022 0.07 -10000 0 -0.44 9 9
MAP2K2 -0.023 0.049 0.11 1 -0.13 88 89
SMPD3 -0.016 0.04 -10000 0 -0.21 11 11
TNF -0.005 0.01 0.24 1 -10000 0 1
PKC zeta/PAR4 -0.007 0 -10000 0 -10000 0 0
mol:PHOSPHOCHOLINE -0.001 0.022 -10000 0 -0.15 6 6
NF kappa B1/RelA/I kappa B alpha 0.007 0.033 -10000 0 -0.17 19 19
AIFM1 0.027 0.054 0.14 94 -10000 0 94
BCL2 -0.055 0.11 0.24 1 -0.31 93 94
Syndecan-3-mediated signaling events

Figure S96.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S96.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CTTN -0.005 0.015 0.24 2 -10000 0 2
Syndecan-3/Src/Cortactin 0.006 0.084 -10000 0 -0.5 7 7
Syndecan-3/Neurocan -0.015 0.057 -10000 0 -0.51 7 7
POMC -0.005 0.01 0.24 1 -10000 0 1
EGFR -0.03 0.083 0.24 1 -0.31 46 47
Syndecan-3/EGFR -0.026 0.068 -10000 0 -0.53 7 7
AGRP -0.006 0 -10000 0 -10000 0 0
NCSTN -0.005 0.01 0.24 1 -10000 0 1
PSENEN -0.016 0.054 -10000 0 -0.31 19 19
RP11-540L11.1 0 0 -10000 0 -10000 0 0
APH1B -0.038 0.093 -10000 0 -0.31 61 61
APH1A -0.005 0.01 0.24 1 -10000 0 1
NCAN -0.006 0 -10000 0 -10000 0 0
long-term memory -0.033 0.071 -10000 0 -0.5 7 7
Syndecan-3/IL8 0.001 0.076 -10000 0 -0.51 7 7
PSEN1 -0.005 0.01 0.24 1 -10000 0 1
Src/Cortactin -0.006 0.01 0.17 2 -10000 0 2
FYN -0.047 0.1 0.24 1 -0.31 79 80
limb bud formation -0.014 0.059 -10000 0 -0.52 7 7
MC4R 0 0 -10000 0 -10000 0 0
SRC -0.006 0 -10000 0 -10000 0 0
PTN 0.011 0.12 0.24 77 -0.31 32 109
FGFR/FGF/Syndecan-3 -0.014 0.059 -10000 0 -0.53 7 7
neuron projection morphogenesis -0.01 0.076 -10000 0 -0.49 7 7
Syndecan-3/AgRP -0.015 0.057 -10000 0 -0.51 7 7
Syndecan-3/AgRP/MC4R -0.015 0.055 -10000 0 -0.49 7 7
Fyn/Cortactin -0.034 0.072 0.17 3 -0.21 79 82
SDC3 -0.014 0.06 -10000 0 -0.53 7 7
GO:0007205 0 0 -10000 0 -10000 0 0
positive regulation of leukocyte migration 0.001 0.075 -10000 0 -0.5 7 7
IL8 0.019 0.074 0.24 57 -10000 0 57
Syndecan-3/Fyn/Cortactin -0.034 0.073 -10000 0 -0.51 7 7
Syndecan-3/CASK -0.013 0.057 -10000 0 -0.51 7 7
alpha-MSH/MC4R -0.003 0.007 0.17 1 -10000 0 1
Gamma Secretase -0.01 0.059 -10000 0 -0.15 79 79
E-cadherin signaling in the nascent adherens junction

Figure S97.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S97.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
CTTN -0.016 0.061 -10000 0 -0.37 15 15
KLHL20 -0.046 0.068 0.3 1 -0.29 7 8
CYFIP2 -0.012 0.042 -10000 0 -0.31 11 11
Rac1/GDP -0.022 0.042 -10000 0 -0.24 15 15
ENAH -0.017 0.06 -10000 0 -0.37 15 15
AP1M1 -0.004 0.018 0.24 3 -10000 0 3
RAP1B -0.004 0.023 0.24 5 -10000 0 5
RAP1A -0.005 0.01 0.24 1 -10000 0 1
CTNNB1 -0.005 0.015 0.24 2 -10000 0 2
CDC42/GTP -0.023 0.029 -10000 0 -0.21 5 5
ABI1/Sra1/Nap1 -0.037 0.045 -10000 0 -0.11 102 102
E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.002 0.029 0.15 3 -0.16 14 17
RAPGEF1 -0.019 0.053 -10000 0 -0.35 13 13
CTNND1 -0.006 0.001 -10000 0 -10000 0 0
regulation of calcium-dependent cell-cell adhesion -0.015 0.062 -10000 0 -0.38 15 15
CRK -0.018 0.057 -10000 0 -0.37 13 13
E-cadherin/gamma catenin/alpha catenin -0.005 0.042 -10000 0 -0.19 26 26
alphaE/beta7 Integrin -0.007 0.011 0.17 1 -0.21 1 2
IQGAP1 -0.006 0.021 0.24 1 -0.31 2 3
NCKAP1 -0.002 0.031 0.24 9 -10000 0 9
Rap1/GTP/I-afadin -0.003 0.04 0.15 6 -0.16 29 35
DLG1 -0.003 0.073 -10000 0 -0.37 15 15
ChemicalAbstracts:7440-70-2 0 0 -10000 0 -10000 0 0
mol:PI-3-4-5-P3 -0.031 0.039 -10000 0 -0.16 16 16
MLLT4 -0.021 0.066 -10000 0 -0.31 29 29
ARF6/GTP/NME1/Tiam1 0.011 0.035 0.15 31 -0.16 2 33
PI3K -0.039 0.049 -10000 0 -0.2 16 16
ARF6 -0.006 0.013 -10000 0 -0.31 1 1
mol:Ca2+ 0 0 -10000 0 -10000 0 0
E-cadherin/gamma catenin -0.016 0.045 -10000 0 -0.23 24 24
TIAM1 -0.006 0.019 0.24 2 -0.31 1 3
E-cadherin(dimer)/Ca2+ 0.001 0.028 0.14 2 -0.15 15 17
AKT1 -0.025 0.03 -10000 0 -0.12 15 15
PIK3R1 -0.075 0.13 -10000 0 -0.31 131 131
CDH1 -0.013 0.045 -10000 0 -0.31 13 13
RhoA/GDP -0.02 0.041 -10000 0 -0.24 15 15
actin cytoskeleton organization -0.034 0.051 0.25 1 -0.22 6 7
CDC42/GDP -0.02 0.041 -10000 0 -0.24 15 15
E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.012 0.042 -10000 0 -0.2 26 26
ITGB7 -0.006 0.016 0.24 1 -0.31 1 2
RAC1 -0.006 0.013 -10000 0 -0.31 1 1
E-cadherin/beta catenin/alpha catenin/p120 catenin 0.001 0.03 0.15 2 -0.16 15 17
E-cadherin/Ca2+/beta catenin/alpha catenin 0 0.026 0.14 2 -0.15 15 17
mol:GDP -0.021 0.047 -10000 0 -0.27 15 15
CDC42/GTP/IQGAP1 0.003 0.013 0.15 1 -0.18 2 3
JUP -0.013 0.045 -10000 0 -0.31 13 13
p120 catenin/RhoA/GDP -0.021 0.042 -10000 0 -0.24 14 14
RAC1/GTP/IQGAP1 0.002 0.015 0.15 1 -0.18 3 4
PIP5K1C/AP1M1 -0.006 0.013 0.17 3 -10000 0 3
RHOA -0.007 0.018 -10000 0 -0.31 2 2
CDC42 -0.006 0 -10000 0 -10000 0 0
CTNNA1 -0.007 0.018 -10000 0 -0.31 2 2
positive regulation of S phase of mitotic cell cycle -0.045 0.07 0.36 1 -0.16 136 137
NME1 0.007 0.054 0.24 29 -10000 0 29
clathrin coat assembly 0 0 -10000 0 -10000 0 0
TJP1 -0.016 0.061 -10000 0 -0.37 15 15
regulation of cell-cell adhesion -0.021 0.026 -10000 0 -0.15 15 15
WASF2 -0.031 0.035 -10000 0 -0.12 35 35
Rap1/GTP -0.022 0.035 -10000 0 -0.23 5 5
E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.004 0.039 -10000 0 -0.16 27 27
CCND1 -0.056 0.086 0.39 1 -0.2 140 141
VAV2 -0.022 0.078 -10000 0 -0.44 16 16
RAP1/GDP -0.02 0.039 -10000 0 -0.22 9 9
adherens junction assembly -0.016 0.059 -10000 0 -0.36 15 15
homophilic cell adhesion 0 0 -10000 0 -10000 0 0
ABI1 -0.005 0.01 0.24 1 -10000 0 1
PIP5K1C -0.006 0 -10000 0 -10000 0 0
regulation of heterotypic cell-cell adhesion -0.019 0.034 0.14 1 -0.28 2 3
E-cadherin/beta catenin -0.008 0.039 -10000 0 -0.27 12 12
mol:GTP 0 0 -10000 0 -10000 0 0
SRC -0.017 0.06 -10000 0 -0.38 14 14
PIK3CA 0.047 0.1 0.24 122 -10000 0 122
Rac1/GTP -0.07 0.1 0.4 1 -0.41 12 13
E-cadherin/beta catenin/alpha catenin 0 0.031 0.16 2 -0.18 15 17
ITGAE -0.006 0 -10000 0 -10000 0 0
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.015 0.063 -10000 0 -0.38 15 15
Signaling events mediated by VEGFR1 and VEGFR2

Figure S98.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S98.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
alphaV beta3 Integrin -0.026 0.088 0.19 28 -0.22 78 106
AKT1 -0.049 0.11 -10000 0 -0.36 3 3
PTK2B -0.049 0.1 0.26 8 -0.28 40 48
VEGFR2 homodimer/Frs2 -0.045 0.078 0.27 2 -0.25 2 4
CAV1 -0.053 0.11 0.24 2 -0.31 90 92
CALM1 -0.012 0.042 -10000 0 -0.31 11 11
VEGFR2 homodimer/VEGFA homodimer/Frs2 -0.032 0.087 0.35 2 -0.28 2 4
endothelial cell proliferation -0.041 0.089 -10000 0 -0.32 5 5
mol:Ca2+ -0.037 0.077 0.36 1 -0.34 2 3
VEGFR2 homodimer/VEGFA homodimer/IQGAP1/Rac -0.035 0.083 0.3 2 -0.28 4 6
RP11-342D11.1 -0.037 0.077 0.36 1 -0.34 2 3
CDH5 -0.006 0 -10000 0 -10000 0 0
VEGFA homodimer 0.023 0.043 0.15 53 -0.16 3 56
SHC1 -0.006 0 -10000 0 -10000 0 0
SHC2 -0.023 0.071 -10000 0 -0.31 33 33
HRAS/GDP -0.046 0.054 -10000 0 -0.31 2 2
SH2D2A -0.006 0 -10000 0 -10000 0 0
VEGFR2 homodimer/VEGFA homodimer/SHP1/eNOS -0.034 0.08 0.26 1 -0.31 4 5
VEGFR2 homodimer/VEGFA homodimer/TsAd -0.036 0.085 0.16 42 -0.28 2 44
VEGFR1 homodimer -0.006 0 -10000 0 -10000 0 0
SHC/GRB2/SOS1 -0.034 0.077 0.24 2 -0.33 2 4
GRB10 -0.038 0.077 0.36 1 -0.34 2 3
PTPN11 -0.006 0 -10000 0 -10000 0 0
GRB2 -0.006 0 -10000 0 -10000 0 0
PAK1 0.002 0.043 0.24 18 -10000 0 18
VEGFR2 homodimer/VEGFA homodimer/IQGAP1/Cadherin/beta catenin -0.035 0.079 0.29 2 -0.26 3 5
HRAS -0.006 0 -10000 0 -10000 0 0
VEGF/Rho/ROCK1/Integrin Complex -0.041 0.1 0.23 5 -0.3 37 42
HIF1A -0.007 0.022 -10000 0 -0.31 3 3
FRS2 0.001 0.04 0.24 15 -10000 0 15
oxygen and reactive oxygen species metabolic process -0.036 0.079 -10000 0 -0.28 4 4
mol:GTP 0 0 -10000 0 -10000 0 0
FLT4 -0.006 0 -10000 0 -10000 0 0
Nck/Pak 0.012 0.054 0.17 60 -10000 0 60
VEGFR2 homodimer/VEGFA homodimer/Fyn -0.056 0.098 0.16 36 -0.31 19 55
mol:GDP -0.037 0.07 -10000 0 -0.32 2 2
mol:NADP -0.032 0.069 0.25 1 -0.28 3 4
eNOS/Hsp90 -0.032 0.067 0.24 1 -0.27 3 4
PIK3R1 -0.075 0.13 -10000 0 -0.31 131 131
mol:IP3 -0.038 0.077 0.36 1 -0.35 2 3
HIF1A/ARNT -0.008 0.017 0.17 1 -0.21 3 4
SHB -0.006 0 -10000 0 -10000 0 0
VEGFA 0.013 0.07 0.24 49 -10000 0 49
VEGFC -0.047 0.1 -10000 0 -0.31 77 77
FAK1/Vinculin -0.05 0.12 0.31 3 -0.33 37 40
mol:Ca ++ 0 0 -10000 0 -10000 0 0
RHOA -0.007 0.018 -10000 0 -0.31 2 2
VEGFR2 homodimer/VEGFA homodimer/alphaV beta3 Integrin -0.046 0.11 0.31 8 -0.3 39 47
PTPN6 -0.006 0 -10000 0 -10000 0 0
EPAS1 -0.08 0.13 0.18 2 -0.31 132 134
mol:L-citrulline -0.032 0.069 0.25 1 -0.28 3 4
ITGAV 0.001 0.05 0.24 19 -0.31 3 22
PIK3CA 0.047 0.1 0.24 122 -10000 0 122
VEGFR2 homodimer/VEGFA homodimer/Frs2/GRB2 -0.031 0.083 0.3 3 -0.26 2 5
VEGFR2 homodimer/VEGFA homodimer -0.038 0.088 0.32 2 -0.37 2 4
VEGFR2/3 heterodimer -0.05 0.075 0.27 2 -0.25 2 4
VEGFB -0.017 0.057 -10000 0 -0.31 21 21
MAPK11 -0.038 0.081 0.39 1 -0.36 2 3
VEGFR2 homodimer -0.057 0.092 0.4 2 -0.29 2 4
FLT1 -0.006 0 -10000 0 -10000 0 0
NEDD4 -0.007 0.016 0.24 2 -10000 0 2
MAPK3 -0.037 0.074 0.35 1 -0.32 2 3
MAPK1 -0.036 0.072 0.35 1 -0.32 2 3
VEGFA145/NRP2 0.016 0.064 0.18 74 -10000 0 74
VEGFR1/2 heterodimer -0.05 0.075 0.27 2 -0.25 2 4
KDR -0.057 0.092 0.41 2 -0.29 2 4
VEGFA165/NRP1/VEGFR2 homodimer -0.028 0.089 0.31 4 -0.34 2 6
SRC -0.006 0 -10000 0 -10000 0 0
platelet activating factor biosynthetic process -0.037 0.074 0.36 1 -0.33 2 3
PI3K -0.041 0.11 -10000 0 -0.36 3 3
VEGFR2 homodimer/VEGFA homodimer/NCK1 -0.024 0.098 0.32 5 -0.28 2 7
FES -0.039 0.078 0.36 1 -0.35 2 3
GAB1 -0.04 0.087 0.28 2 -0.37 4 6
VEGFR2 homodimer/VEGFA homodimer/Src -0.036 0.085 0.39 1 -0.28 2 3
CTNNB1 -0.005 0.015 0.24 2 -10000 0 2
SOS1 0.005 0.05 0.24 24 -10000 0 24
ARNT -0.005 0.01 0.24 1 -10000 0 1
eNOS/Caveolin-1 -0.048 0.084 -10000 0 -0.35 4 4
VEGFR2 homodimer/VEGFA homodimer/Yes -0.029 0.087 0.39 1 -0.28 2 3
PI3K/GAB1 -0.069 0.14 -10000 0 -0.37 32 32
VEGFR2 homodimer/VEGFA homodimer/Frs2/Nck/Pak -0.016 0.095 0.28 13 -0.26 2 15
PRKACA -0.006 0 -10000 0 -10000 0 0
VEGFR2/3 heterodimer/VEGFC homodimer -0.068 0.083 -10000 0 -0.3 21 21
HSP90AA1 -0.006 0.013 -10000 0 -0.31 1 1
CDC42 -0.039 0.078 0.36 1 -0.35 2 3
actin cytoskeleton reorganization -0.036 0.084 0.16 42 -0.28 2 44
PTK2 -0.052 0.12 0.33 3 -0.34 39 42
EDG1 -0.04 0.084 0.36 1 -0.43 6 7
mol:DAG -0.038 0.077 0.36 1 -0.35 2 3
CaM/Ca2+ -0.04 0.071 -10000 0 -0.29 5 5
MAP2K3 -0.038 0.076 0.29 2 -0.34 2 4
VEGFR2 homodimer/VEGFA homodimer/GRB10/NEDD4 -0.037 0.084 0.31 2 -0.35 2 4
PLCG1 -0.038 0.078 0.36 1 -0.35 2 3
VEGFR2 homodimer/VEGFA homodimer/Src/Shb -0.034 0.081 0.3 2 -0.26 2 4
IQGAP1 -0.006 0.021 0.24 1 -0.31 2 3
YES1 0.006 0.052 0.24 26 -10000 0 26
VEGFR2 homodimer/VEGFA homodimer/SHP2 -0.036 0.085 0.39 1 -0.28 2 3
VEGFR2 homodimer/VEGFA homodimer/SHP1 -0.036 0.085 0.39 1 -0.28 2 3
cell migration -0.05 0.11 0.3 3 -0.4 9 12
mol:PI-3-4-5-P3 -0.038 0.1 -10000 0 -0.34 3 3
FYN -0.047 0.1 0.24 1 -0.31 79 80
VEGFB/NRP1 -0.041 0.079 0.33 1 -0.29 12 13
mol:NO -0.032 0.069 0.25 1 -0.28 3 4
PXN -0.01 0.033 -10000 0 -0.31 7 7
HRAS/GTP -0.045 0.054 -10000 0 -0.31 2 2
VEGFR2 homodimer/VEGFA homodimer/GRB10 -0.037 0.084 0.39 1 -0.35 2 3
VHL -0.004 0.018 0.24 3 -10000 0 3
ITGB3 -0.041 0.11 0.24 12 -0.31 77 89
NOS3 -0.035 0.074 0.26 1 -0.31 3 4
VEGFR2 homodimer/VEGFA homodimer/Sck -0.044 0.092 0.39 1 -0.3 10 11
RAC1 -0.006 0.013 -10000 0 -0.31 1 1
PRKCA -0.037 0.076 0.29 2 -0.31 4 6
PRKCB -0.036 0.072 0.34 1 -0.33 2 3
VCL -0.005 0.015 0.24 2 -10000 0 2
VEGFA165/NRP1 -0.034 0.082 0.38 1 -0.34 2 3
VEGFR1/2 heterodimer/VEGFA homodimer -0.036 0.085 0.39 1 -0.28 2 3
VEGFA165/NRP2 0.016 0.064 0.18 74 -10000 0 74
MAPKKK cascade -0.033 0.076 0.34 1 -0.31 2 3
NRP2 0.006 0.054 0.24 28 -10000 0 28
VEGFC homodimer -0.047 0.1 -10000 0 -0.31 77 77
NCK1 0.012 0.065 0.24 42 -10000 0 42
ROCK1 -0.005 0.01 0.24 1 -10000 0 1
FAK1/Paxillin -0.052 0.12 0.31 3 -0.33 40 43
MAP3K13 -0.037 0.081 0.32 2 -0.35 2 4
PDPK1 -0.039 0.094 -10000 0 -0.31 3 3
IL27-mediated signaling events

Figure S99.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S99.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TGFB1 -0.054 0.11 -10000 0 -0.31 90 90
CD4-positive alpha-beta T cell lineage commitment 0 0.001 -10000 0 -10000 0 0
cytokine production during immune response -0.002 0.085 0.51 5 -0.39 2 7
IL27/IL27R/JAK1 -0.01 0.095 0.48 1 -0.94 3 4
TBX21 0.043 0.1 0.44 5 -0.57 3 8
IL12B -0.003 0.011 -10000 0 -10000 0 0
IL12A 0.007 0.045 0.2 28 -0.21 1 29
IL6ST -0.012 0.053 -10000 0 -0.32 16 16
IL27RA/JAK1 -0.006 0.08 -10000 0 -1 3 3
IL27 -0.004 0.013 -10000 0 -10000 0 0
TYK2 -0.002 0.02 -10000 0 -10000 0 0
T-helper cell lineage commitment -0.036 0.09 -10000 0 -10000 0 0
T-helper 2 cell differentiation -0.002 0.085 0.51 5 -0.39 2 7
T cell proliferation during immune response -0.002 0.085 0.51 5 -0.39 2 7
MAPKKK cascade 0.002 0.085 0.39 2 -0.51 5 7
STAT3 -0.011 0.04 -10000 0 -0.31 10 10
STAT2 0.022 0.078 0.24 64 -10000 0 64
STAT1 0.13 0.12 0.24 314 -10000 0 314
IL12RB1 -0.004 0.006 -10000 0 -10000 0 0
positive regulation of tyrosine phosphorylation of STAT protein 0 0 -10000 0 -10000 0 0
IL12RB2 0.046 0.11 0.5 8 -0.57 3 11
IL27/IL27R/JAK2/TYK2 0.002 0.086 0.39 2 -0.51 5 7
positive regulation of T cell mediated cytotoxicity 0.002 0.085 0.39 2 -0.51 5 7
STAT1 (dimer) 0.06 0.12 0.47 5 -0.79 3 8
JAK2 -0.003 0.029 0.27 2 -0.31 2 4
JAK1 -0.007 0.018 -10000 0 -0.31 2 2
STAT2 (dimer) 0.017 0.095 0.4 8 -0.44 5 13
T cell proliferation -0.001 0.085 0.42 2 -0.49 5 7
IL12/IL12R/TYK2/JAK2 0.026 0.075 0.42 3 -10000 0 3
IL17A -0.036 0.09 -10000 0 -10000 0 0
mast cell activation -0.002 0.085 0.51 5 -0.39 2 7
IFNG 0.009 0.044 0.2 26 -10000 0 26
T cell differentiation 0 0.005 0.021 24 -0.023 3 27
STAT3 (dimer) -0.003 0.082 0.34 2 -0.52 5 7
STAT5A (dimer) -0.003 0.08 0.34 2 -0.49 5 7
STAT4 (dimer) 0 0.078 0.34 2 -0.47 5 7
STAT4 -0.004 0.018 0.24 3 -10000 0 3
T cell activation 0 0.012 0.12 3 -0.18 1 4
IL27R/JAK2/TYK2 -0.005 0.099 0.39 2 -0.97 3 5
GATA3 -0.003 0.033 -10000 0 -10000 0 0
IL18 0.036 0.08 0.2 108 -10000 0 108
positive regulation of mast cell cytokine production -0.003 0.081 0.33 2 -0.5 5 7
IL27/EBI3 -0.003 0.023 0.15 1 -10000 0 1
IL27RA -0.003 0.085 0.37 1 -1.1 3 4
IL6 -0.007 0.05 0.24 10 -0.31 9 19
STAT5A -0.01 0.036 -10000 0 -0.31 8 8
monocyte differentiation 0.001 0.002 -10000 0 -10000 0 0
IL2 -0.001 0.041 0.45 3 -0.41 1 4
IL1B 0.011 0.052 0.2 40 -10000 0 40
EBI3 -0.004 0.013 -10000 0 -10000 0 0
TNF -0.003 0.009 0.2 1 -10000 0 1
Ephrin A reverse signaling

Figure S100.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S100.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
MAPKKK cascade 0.006 0.018 0.15 4 -0.17 3 7
EFNA5 -0.006 0.03 0.24 4 -0.31 3 7
FYN -0.028 0.055 0.14 4 -0.16 80 84
neuron projection morphogenesis 0.006 0.018 0.15 4 -0.17 3 7
cell-cell signaling 0 0 -10000 0 -10000 0 0
Ephrin A5/EPHA5 0.006 0.018 0.15 4 -0.18 3 7
EPHA5 -0.006 0 -10000 0 -10000 0 0
Regulation of p38-alpha and p38-beta

Figure S101.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S101.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
RIP1/MEKK3 0.006 0 -10000 0 -10000 0 0
response to insulin stimulus 0 0 -10000 0 -10000 0 0
RIPK1 -0.006 0 -10000 0 -10000 0 0
response to stress 0 0 -10000 0 -10000 0 0
MAP2K6 0.03 0.087 0.24 82 -10000 0 82
mol:GTP 0 0 -10000 0 -10000 0 0
MAP2K4 -0.009 0.031 -10000 0 -0.31 6 6
RAC1-CDC42/GTP/PAK family -0.045 0.076 -10000 0 -0.17 158 158
response to UV 0 0 -10000 0 -10000 0 0
YES1 0.006 0.052 0.24 26 -10000 0 26
interleukin-1 receptor activity 0 0 -10000 0 -10000 0 0
tumor necrosis factor receptor activity 0 0 -10000 0 -10000 0 0
MAP3K3 -0.006 0 -10000 0 -10000 0 0
FYN -0.047 0.1 0.24 1 -0.31 79 80
MAP3K12 -0.006 0 -10000 0 -10000 0 0
FGR -0.006 0 -10000 0 -10000 0 0
p38 alpha/TAB1 -0.019 0.056 -10000 0 -0.24 4 4
PRKG1 -0.005 0.01 0.24 1 -10000 0 1
DUSP8 -0.006 0 -10000 0 -10000 0 0
PGK/cGMP/p38 alpha -0.025 0.047 0.13 1 -0.24 4 5
apoptosis -0.02 0.053 -10000 0 -0.24 4 4
RAL/GTP 0.006 0.009 0.15 2 -10000 0 2
LYN -0.014 0.048 -10000 0 -0.31 15 15
DUSP1 -0.065 0.12 0.24 3 -0.31 114 117
PAK1 0.002 0.043 0.24 18 -10000 0 18
SRC -0.006 0 -10000 0 -10000 0 0
RAC1/OSM/MEKK3/MKK3 0.01 0.012 -10000 0 -0.16 3 3
TRAF6 -0.005 0.015 0.24 2 -10000 0 2
RAC1 -0.006 0.013 -10000 0 -0.31 1 1
epidermal growth factor receptor activity 0 0 -10000 0 -10000 0 0
mol:LPS 0 0 -10000 0 -10000 0 0
mol:cGMP 0 0 -10000 0 -10000 0 0
CCM2 -0.006 0 -10000 0 -10000 0 0
RAC1-CDC42/GTP 0.006 0.008 -10000 0 -0.18 1 1
MAPK11 -0.024 0.078 0.17 6 -0.24 22 28
BLK -0.005 0.01 0.24 1 -10000 0 1
HCK -0.005 0.01 0.24 1 -10000 0 1
MAP2K3 -0.007 0.018 -10000 0 -0.31 2 2
DUSP16 -0.004 0.023 0.24 5 -10000 0 5
DUSP10 0.003 0.047 0.24 21 -10000 0 21
TRAF6/MEKK3 0.006 0.008 0.15 2 -10000 0 2
MAP3K7IP1 -0.006 0 -10000 0 -10000 0 0
MAPK14 -0.018 0.06 -10000 0 -0.26 4 4
positive regulation of innate immune response -0.028 0.084 0.18 6 -0.26 22 28
LCK -0.006 0 -10000 0 -10000 0 0
p38alpha-beta/MKP7 -0.027 0.084 0.19 9 -0.25 22 31
p38alpha-beta/MKP5 -0.024 0.084 0.19 7 -0.25 21 28
PGK/cGMP -0.003 0.007 0.17 1 -10000 0 1
PAK2 -0.004 0.018 0.24 3 -10000 0 3
p38alpha-beta/MKP1 -0.042 0.098 0.17 5 -0.29 36 41
CDC42 -0.006 0 -10000 0 -10000 0 0
RALB -0.006 0 -10000 0 -10000 0 0
RALA -0.005 0.015 0.24 2 -10000 0 2
PAK3 -0.094 0.14 0.24 2 -0.31 167 169
Calcineurin-regulated NFAT-dependent transcription in lymphocytes

Figure S102.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S102.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
FOXP3 -0.005 0.025 0.18 9 -10000 0 9
NFATC2 -0.045 0.17 0.37 6 -0.54 16 22
NFATC3 0.005 0.046 0.29 3 -0.27 1 4
CD40LG -0.015 0.17 0.63 6 -0.94 1 7
ITCH -0.007 0.057 0.29 15 -10000 0 15
CBLB -0.008 0.055 0.28 15 -10000 0 15
CD4-positive CD25-positive alpha-beta regulatory T cell lineage commitment -0.037 0.14 0.57 10 -0.56 4 14
JUNB -0.077 0.13 -10000 0 -0.31 135 135
CaM/Ca2+/Calcineurin A alpha-beta B1 -0.016 0.029 -10000 0 -0.22 11 11
T cell anergy -0.01 0.07 0.36 13 -10000 0 13
TLE4 -0.059 0.18 0.4 1 -0.56 55 56
Jun/NFAT1-c-4/p21SNFT -0.006 0.14 -10000 0 -0.94 1 1
AP-1/NFAT1-c-4 -0.01 0.19 0.57 6 -1.1 1 7
IKZF1 -0.028 0.11 -10000 0 -0.39 14 14
T-helper 2 cell differentiation -0.021 0.13 -10000 0 -0.54 8 8
AP-1/NFAT1 -0.028 0.14 0.32 17 -0.37 30 47
CALM1 -0.014 0.049 -10000 0 -0.32 11 11
EGR2 -0.007 0.13 0.75 3 -0.86 1 4
EGR3 -0.008 0.12 0.7 2 -0.86 1 3
NFAT1/FOXP3 -0.028 0.12 0.4 7 -0.39 15 22
EGR1 -0.12 0.15 0.24 3 -0.31 212 215
JUN 0.005 0.047 0.24 15 -0.31 1 16
EGR4 -0.006 0.004 -10000 0 -10000 0 0
mol:Ca2+ -0.002 0.022 0.13 15 -10000 0 15
GBP3 -0.039 0.19 0.42 24 -0.56 43 67
FOSL1 -0.006 0 -10000 0 -10000 0 0
NFAT1-c-4/MAF/IRF4 -0.016 0.12 -10000 0 -0.94 1 1
DGKA -0.024 0.12 0.43 7 -0.38 15 22
CREM -0.005 0.01 0.24 1 -10000 0 1
NFAT1-c-4/PPARG -0.015 0.12 -10000 0 -0.98 1 1
CTLA4 -0.024 0.11 0.51 7 -0.33 14 21
NFAT1-c-4 (dimer)/EGR1 -0.075 0.14 0.47 1 -1.1 1 2
NFAT1-c-4 (dimer)/EGR4 -0.017 0.12 0.47 1 -0.98 1 2
FOS -0.019 0.11 0.24 29 -0.31 53 82
IFNG -0.021 0.15 0.47 25 -0.52 4 29
T cell activation -0.013 0.12 0.59 2 -0.58 1 3
MAF -0.006 0 -10000 0 -10000 0 0
T-helper 2 cell lineage commitment 0 0 -10000 0 -10000 0 0
activation-induced cell death of T cells 0.003 0.11 1.2 1 -0.63 3 4
TNF -0.072 0.14 0.6 2 -0.97 1 3
FASLG -0.008 0.13 0.74 1 -0.93 1 2
TBX21 0.003 0.044 0.2 26 -10000 0 26
BATF3 0 0 -10000 0 -10000 0 0
PRKCQ -0.01 0.048 0.24 5 -0.31 11 16
PTPN1 -0.028 0.11 -10000 0 -0.39 14 14
NFAT1-c-4/ICER1 -0.016 0.12 -10000 0 -0.98 1 1
GATA3 -0.005 0.015 0.24 2 -10000 0 2
T-helper 1 cell differentiation -0.02 0.15 0.47 25 -0.51 4 29
IL2RA -0.039 0.14 0.56 8 -0.55 5 13
T-helper 1 cell lineage commitment 0 0 -10000 0 -10000 0 0
CASP3 -0.024 0.12 0.43 9 -0.39 14 23
E2F1 -0.005 0.013 0.14 4 -10000 0 4
PPARG -0.004 0.023 0.24 5 -10000 0 5
SLC3A2 -0.027 0.12 0.41 2 -0.38 15 17
IRF4 -0.005 0.015 0.24 2 -10000 0 2
PTGS2 -0.011 0.18 0.68 9 -0.94 1 10
CSF2 -0.015 0.17 0.63 6 -0.94 1 7
JunB/Fra1/NFAT1-c-4 -0.051 0.14 -10000 0 -0.8 2 2
IL4 -0.022 0.14 -10000 0 -0.56 8 8
IL5 -0.015 0.17 0.63 6 -0.94 1 7
IL2 -0.013 0.12 0.59 2 -0.58 1 3
IL3 -0.018 0.023 -10000 0 -10000 0 0
RNF128 -0.007 0.059 0.42 6 -10000 0 6
NFATC1 -0.003 0.11 0.63 3 -1.2 1 4
CDK4 0.008 0.11 0.62 4 -0.64 1 5
PTPRK -0.03 0.13 0.4 3 -0.44 19 22
IL8 0.003 0.21 0.67 13 -0.94 1 14
POU2F1 -0.006 0 -10000 0 -10000 0 0
Arf6 downstream pathway

Figure S103.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S103.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
PLAUR 0.004 0.081 0.5 13 -10000 0 13
regulation of axonogenesis -0.011 0.043 0.32 1 -0.16 16 17
myoblast fusion -0.005 0.045 -10000 0 -0.28 13 13
mol:GTP 0.008 0.029 0.18 13 -0.29 1 14
regulation of calcium-dependent cell-cell adhesion -0.019 0.048 0.18 2 -0.23 13 15
ARF1/GTP 0 0.048 0.15 11 -0.19 28 39
mol:GM1 0.003 0.026 0.16 13 -0.22 1 14
mol:Choline 0.007 0.044 0.15 47 -0.2 1 48
lamellipodium assembly 0.003 0.049 0.29 13 -0.4 1 14
MAPK3 -0.001 0.057 0.32 13 -0.19 14 27
ARF6/GTP/NME1/Tiam1 0.019 0.048 0.18 43 -0.18 2 45
ARF1 -0.021 0.066 -10000 0 -0.31 29 29
ARF6/GDP 0.005 0.045 0.28 13 -10000 0 13
ARF1/GDP 0.002 0.043 0.24 11 -0.21 6 17
ARF6 0.008 0.016 -10000 0 -10000 0 0
RAB11A -0.006 0 -10000 0 -10000 0 0
TIAM1 -0.005 0.02 0.24 2 -0.31 1 3
fibronectin binding 0 0 -10000 0 -10000 0 0
MAPK1 0.004 0.05 0.31 14 -0.2 2 16
actin filament bundle formation 0.001 0.02 0.28 1 -10000 0 1
KALRN -0.004 0.02 0.13 4 -0.28 1 5
RAB11FIP3/RAB11A -0.007 0 -10000 0 -10000 0 0
RhoA/GDP -0.001 0.02 -10000 0 -0.28 1 1
NME1 0.007 0.055 0.24 29 -10000 0 29
Rac1/GDP -0.001 0.019 -10000 0 -0.28 1 1
substrate adhesion-dependent cell spreading 0.008 0.029 0.18 13 -0.29 1 14
cortical actin cytoskeleton organization 0.003 0.049 0.29 13 -0.4 1 14
RAC1 -0.006 0.013 -10000 0 -0.31 1 1
liver development 0.008 0.029 0.18 13 -0.29 1 14
ARF6/GTP 0.008 0.029 0.18 13 -0.29 1 14
RhoA/GTP 0.009 0.027 0.15 13 -0.2 3 16
mol:GDP 0.007 0.051 0.33 13 -0.3 1 14
ARF6/GTP/RAB11FIP3/RAB11A 0.012 0.022 0.14 13 -0.2 1 14
RHOA -0.007 0.018 -10000 0 -0.31 2 2
PLD1 0.011 0.051 0.18 47 -0.23 1 48
RAB11FIP3 -0.006 0 -10000 0 -10000 0 0
tube morphogenesis 0.003 0.049 0.29 13 -0.4 1 14
ruffle organization 0.011 0.043 0.16 16 -0.32 1 17
regulation of epithelial cell migration 0.008 0.029 0.18 13 -0.29 1 14
PLD2 0 0.027 0.16 13 -0.23 1 14
PIP5K1A 0.011 0.043 0.16 16 -0.32 1 17
mol:Phosphatidic acid 0.007 0.044 0.15 47 -0.2 1 48
Rac1/GTP 0.003 0.049 0.29 13 -0.41 1 14
BCR signaling pathway

Figure S104.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S104.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
JUN -0.007 0.054 -10000 0 -0.25 12 12
IKBKB -0.001 0.041 -10000 0 -10000 0 0
AKT1 -0.029 0.059 0.17 5 -0.17 14 19
IKBKG -0.004 0.035 -10000 0 -10000 0 0
CALM1 -0.011 0.051 -10000 0 -0.23 17 17
PIK3CA 0.047 0.1 0.24 122 -10000 0 122
MAP3K1 -0.01 0.074 0.21 1 -0.36 13 14
MAP3K7 -0.003 0.025 0.24 6 -10000 0 6
mol:Ca2+ -0.007 0.05 -10000 0 -0.24 16 16
DOK1 -0.007 0.018 -10000 0 -0.31 2 2
AP-1 -0.01 0.047 0.17 4 -0.18 8 12
LYN -0.014 0.048 -10000 0 -0.31 15 15
BLNK -0.014 0.048 -10000 0 -0.31 15 15
SHC1 -0.006 0 -10000 0 -10000 0 0
BCR complex -0.004 0.02 0.17 7 -10000 0 7
CD22 -0.054 0.095 0.22 3 -0.34 19 22
CAMK2G -0.013 0.048 -10000 0 -0.22 17 17
CSNK2A1 -0.006 0 -10000 0 -10000 0 0
INPP5D 0 0 -10000 0 -10000 0 0
SHC/GRB2/SOS1 -0.022 0.033 -10000 0 -0.23 4 4
GO:0007205 -0.007 0.051 -10000 0 -0.24 16 16
SYK -0.008 0.034 0.24 2 -0.31 6 8
ELK1 -0.009 0.048 -10000 0 -0.23 16 16
NFATC1 -0.01 0.058 0.19 1 -0.26 15 16
B-cell antigen/BCR complex -0.004 0.02 0.17 7 -10000 0 7
PAG1/CSK -0.007 0.007 0.17 1 -10000 0 1
NFKBIB 0 0.021 -10000 0 -0.13 9 9
HRAS -0.01 0.045 -10000 0 -0.22 15 15
NFKBIA 0.001 0.019 -10000 0 -0.12 6 6
NF-kappa-B/RelA/I kappa B beta 0 0.02 -10000 0 -0.13 8 8
RasGAP/Csk 0.021 0.038 0.28 2 -0.15 4 6
mol:GDP -0.007 0.049 -10000 0 -0.23 16 16
PTEN -0.012 0.042 -10000 0 -0.31 11 11
CD79B -0.006 0 -10000 0 -10000 0 0
NF-kappa-B/RelA/I kappa B alpha 0.001 0.019 -10000 0 -0.12 8 8
GRB2 -0.006 0 -10000 0 -10000 0 0
PI3K/BCAP/CD19 -0.072 0.13 0.22 1 -0.34 59 60
PIK3R1 -0.075 0.13 -10000 0 -0.31 131 131
mol:IP3 -0.007 0.051 -10000 0 -0.24 16 16
CSK -0.006 0 -10000 0 -10000 0 0
FOS -0.019 0.068 -10000 0 -0.25 21 21
CHUK 0 0.04 0.18 1 -10000 0 1
IBTK -0.001 0.036 0.24 12 -10000 0 12
CARD11/BCL10/MALT1/TAK1 0.002 0.055 0.17 4 -0.21 14 18
PTPN6 -0.053 0.091 0.2 3 -0.33 19 22
RELA -0.006 0.013 -10000 0 -0.31 1 1
BCL2A1 0 0.018 0.093 1 -0.13 2 3
VAV2 -0.011 0.076 0.23 1 -0.35 16 17
ubiquitin-dependent protein catabolic process 0 0.021 -10000 0 -0.13 8 8
BTK 0.008 0.032 -10000 0 -10000 0 0
CD19 -0.01 0.075 0.22 3 -0.36 14 17
MAP4K1 -0.005 0.015 0.24 2 -10000 0 2
CD72 -0.006 0 -10000 0 -10000 0 0
PAG1 -0.005 0.01 0.24 1 -10000 0 1
MAPK14 -0.01 0.067 0.2 1 -0.31 13 14
SH3BP5 -0.007 0.022 -10000 0 -0.31 3 3
PIK3AP1 -0.009 0.055 -10000 0 -0.27 16 16
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2/CD72 -0.01 0.062 -10000 0 -0.29 21 21
RAF1 -0.011 0.043 -10000 0 -0.21 15 15
RasGAP/p62DOK/SHIP 0.008 0.035 -10000 0 -0.14 6 6
CD79A -0.003 0.027 0.24 7 -10000 0 7
re-entry into mitotic cell cycle -0.01 0.046 0.16 4 -0.17 13 17
RASA1 -0.007 0.022 -10000 0 -0.31 3 3
MAPK3 -0.016 0.041 -10000 0 -0.25 3 3
MAPK1 -0.013 0.038 -10000 0 -0.25 3 3
CD72/SHP1 -0.053 0.087 0.19 3 -0.32 19 22
NFKB1 -0.01 0.033 -10000 0 -0.31 7 7
MAPK8 -0.009 0.065 0.2 1 -0.31 10 11
actin cytoskeleton organization -0.012 0.069 0.22 1 -0.32 16 17
NF-kappa-B/RelA -0.001 0.047 -10000 0 -0.25 10 10
Calcineurin -0.015 0.046 -10000 0 -0.21 17 17
PI3K -0.069 0.073 -10000 0 -0.25 39 39
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 -0.009 0.056 -10000 0 -0.28 16 16
SOS1 0.005 0.05 0.24 24 -10000 0 24
Bam32/HPK1 -0.006 0.086 -10000 0 -0.44 13 13
DAPP1 -0.008 0.093 -10000 0 -0.49 13 13
cytokine secretion -0.009 0.056 0.19 1 -0.25 15 16
mol:DAG -0.007 0.051 -10000 0 -0.24 16 16
PLCG2 -0.006 0 -10000 0 -10000 0 0
MAP2K1 -0.012 0.041 -10000 0 -0.27 3 3
B-cell antigen/BCR complex/FcgammaRIIB 0.018 0.037 0.16 37 -0.18 1 38
mol:PI-3-4-5-P3 -0.044 0.067 0.18 4 -0.2 21 25
ETS1 -0.012 0.048 0.16 1 -0.2 17 18
B-cell antigen/BCR complex/LYN/SYK/BLNK 0.005 0.046 -10000 0 -0.16 33 33
B-cell antigen/BCR complex/LYN -0.013 0.074 0.21 2 -0.37 14 16
MALT1 0.011 0.062 0.24 38 -10000 0 38
TRAF6 -0.005 0.015 0.24 2 -10000 0 2
RAC1 -0.013 0.072 0.22 1 -0.33 16 17
B-cell antigen/BCR complex/LYN/SYK -0.06 0.073 -10000 0 -0.27 19 19
CARD11 -0.009 0.049 -10000 0 -0.23 16 16
FCGR2B 0.008 0.06 0.24 34 -0.31 1 35
PPP3CA -0.008 0.025 -10000 0 -0.31 4 4
BCL10 -0.006 0 -10000 0 -10000 0 0
IKK complex 0.001 0.022 0.1 2 -10000 0 2
PTPRC -0.004 0.11 0.24 53 -0.31 41 94
PDPK1 -0.03 0.055 0.16 5 -0.15 16 21
PPP3CB -0.006 0 -10000 0 -10000 0 0
PPP3CC -0.006 0 -10000 0 -10000 0 0
POU2F2 -0.002 0.015 -10000 0 -0.13 2 2
Calcium signaling in the CD4+ TCR pathway

Figure S105.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S105.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
NFATC1 -0.007 0.034 0.2 2 -0.18 9 11
NFATC2 -0.014 0.048 0.2 2 -0.18 31 33
NFATC3 -0.007 0.034 0.2 2 -0.18 8 10
CD40LG -0.03 0.11 0.46 6 -10000 0 6
PTGS2 -0.028 0.12 0.5 13 -0.44 1 14
JUNB -0.077 0.13 -10000 0 -0.31 135 135
CaM/Ca2+/Calcineurin A alpha-beta B1 -0.01 0.026 -10000 0 -0.2 11 11
CaM/Ca2+ -0.01 0.026 -10000 0 -0.2 11 11
CALM1 -0.01 0.039 -10000 0 -0.31 9 9
JUN 0 0.042 0.24 14 -0.31 1 15
mol:Ca2+ 0 0.007 -10000 0 -10000 0 0
Calcineurin A alpha-beta B1/FKBP12/FK506 -0.002 0.005 -10000 0 -10000 0 0
FOSL1 -0.006 0 -10000 0 -10000 0 0
CREM -0.005 0.01 0.24 1 -10000 0 1
Jun/NFAT1-c-4/p21SNFT -0.017 0.073 0.25 29 -10000 0 29
FOS -0.026 0.11 0.24 26 -0.31 58 84
IFNG -0.02 0.14 0.5 20 -10000 0 20
AP-1/NFAT1-c-4 -0.027 0.13 0.54 6 -10000 0 6
FASLG -0.03 0.11 0.46 6 -10000 0 6
NFAT1-c-4/ICER1 -0.018 0.058 0.21 5 -10000 0 5
IL2RA -0.028 0.12 0.49 11 -10000 0 11
FKBP12/FK506 -0.003 0 -10000 0 -10000 0 0
CSF2 -0.03 0.11 0.46 6 -10000 0 6
JunB/Fra1/NFAT1-c-4 -0.05 0.08 0.2 5 -0.28 18 23
IL4 -0.03 0.11 0.46 6 -10000 0 6
IL2 -0.004 0.005 -10000 0 -10000 0 0
IL3 -0.008 0.009 -10000 0 -10000 0 0
FKBP1A -0.006 0 -10000 0 -10000 0 0
BATF3 0 0 -10000 0 -10000 0 0
mol:FK506 0 0 -10000 0 -10000 0 0
POU2F1 -0.006 0 -10000 0 -10000 0 0
Noncanonical Wnt signaling pathway

Figure S106.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S106.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
NFATC2 -0.018 0.06 -10000 0 -0.31 23 23
GNB1/GNG2 0.016 0.05 0.18 10 -10000 0 10
mol:DAG 0.013 0.048 0.18 11 -10000 0 11
PLCG1 0.014 0.049 0.18 11 -10000 0 11
YES1 0.024 0.06 0.22 18 -10000 0 18
FZD3 0.013 0.074 0.24 48 -0.31 4 52
FZD6 0.008 0.059 0.24 33 -0.31 1 34
G protein 0.013 0.049 0.18 10 -10000 0 10
MAP3K7 0.009 0.045 0.17 15 -10000 0 15
mol:Ca2+ 0.013 0.047 0.18 11 -10000 0 11
mol:IP3 0.013 0.048 0.18 11 -10000 0 11
NLK 0.007 0.012 -10000 0 -10000 0 0
GNB1 -0.006 0.013 -10000 0 -0.31 1 1
CAMK2A 0.011 0.045 0.17 11 -10000 0 11
MAP3K7IP1 -0.006 0 -10000 0 -10000 0 0
Noncanonical Wnts/FZD 0.021 0.055 0.22 10 -0.18 5 15
CSNK1A1 -0.005 0.015 0.24 2 -10000 0 2
GNAS 0.017 0.052 0.2 10 -10000 0 10
GO:0007205 0.014 0.047 0.18 11 -10000 0 11
WNT6 -0.006 0 -10000 0 -10000 0 0
WNT4 -0.006 0 -10000 0 -10000 0 0
NFAT1/CK1 alpha 0.012 0.059 0.19 15 -10000 0 15
GNG2 -0.005 0.01 0.24 1 -10000 0 1
WNT5A -0.003 0.025 0.24 6 -10000 0 6
WNT11 0.016 0.07 0.24 50 -10000 0 50
CDC42 0.02 0.057 0.21 18 -10000 0 18
S1P1 pathway

Figure S107.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S107.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
VEGFR2 homodimer/VEGFA homodimer 0.005 0.059 0.18 50 -0.24 6 56
PDGFRB -0.007 0.035 -10000 0 -0.31 7 7
SPHK1 0 0.01 0.16 1 -10000 0 1
mol:S1P 0 0.022 0.2 3 -10000 0 3
S1P1/S1P/Gi 0.02 0.083 0.39 11 -0.47 4 15
GNAO1 -0.001 0.029 0.24 6 -0.31 1 7
PDGFB-D/PDGFRB/PLCgamma1 0.014 0.079 0.34 12 -0.45 4 16
PLCG1 0.017 0.08 0.36 12 -0.44 4 16
mol:GTP 0 0 -10000 0 -10000 0 0
PDGFB-D/PDGFRB -0.007 0.035 -10000 0 -0.31 7 7
GNAI2 -0.003 0.008 -10000 0 -10000 0 0
GNAI3 0.037 0.092 0.24 96 -10000 0 96
GNAI1 -0.002 0.041 0.24 8 -0.31 5 13
mol:GDP 0 0 -10000 0 -10000 0 0
EDG1 0.001 0.065 0.26 2 -0.43 6 8
S1P1/S1P 0.009 0.066 0.26 7 -0.38 6 13
negative regulation of cAMP metabolic process 0.02 0.082 0.38 11 -0.46 4 15
MAPK3 0.014 0.095 0.45 11 -0.59 4 15
calcium-dependent phospholipase C activity 0 0.003 -10000 0 -10000 0 0
Rac1/GDP -0.004 0.009 -10000 0 -0.21 1 1
RhoA/GDP -0.004 0.012 -10000 0 -0.21 2 2
KDR -0.008 0.021 0.24 2 -0.15 6 8
PLCB2 0.006 0.061 0.24 7 -0.35 6 13
RAC1 -0.006 0.013 -10000 0 -0.31 1 1
RhoA/GTP -0.009 0.037 -10000 0 -0.33 6 6
receptor internalization 0.008 0.062 0.22 15 -0.36 6 21
PTGS2 0.014 0.11 0.53 11 -0.99 3 14
Rac1/GTP -0.009 0.037 -10000 0 -0.33 6 6
RHOA -0.007 0.018 -10000 0 -0.31 2 2
VEGFA 0.013 0.072 0.24 49 -0.15 6 55
negative regulation of T cell proliferation 0.02 0.082 0.38 11 -0.46 4 15
GO:0007205 0 0 -10000 0 -10000 0 0
GNAZ -0.005 0.027 -10000 0 -0.31 4 4
MAPK1 0.017 0.094 0.45 11 -0.59 4 15
S1P1/S1P/PDGFB-D/PDGFRB 0.01 0.076 0.26 14 -0.4 7 21
ABCC1 0 0.029 0.24 8 -10000 0 8
E-cadherin signaling events

Figure S108.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S108.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
E-cadherin/beta catenin-gamma catenin 0.001 0.042 0.16 2 -0.19 24 26
E-cadherin/beta catenin -0.011 0.032 0.17 2 -0.21 13 15
CTNNB1 -0.005 0.015 0.24 2 -10000 0 2
JUP -0.013 0.045 -10000 0 -0.31 13 13
CDH1 -0.013 0.045 -10000 0 -0.31 13 13
Arf1 pathway

Figure S109.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S109.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
coatomer protein complex -0.001 0.007 -10000 0 -10000 0 0
EntrezGene:79658 0 0 -10000 0 -10000 0 0
ARF1/GDP/Membrin/GBF1/p115/Brefeldin A -0.008 0.051 -10000 0 -0.22 29 29
AP2 -0.018 0.053 0.17 6 -0.21 35 41
mol:DAG 0 0 -10000 0 -10000 0 0
Arfaptin 2/Rac/GTP -0.007 0.008 -10000 0 -0.18 1 1
CLTB -0.006 0 -10000 0 -10000 0 0
coatomer protein complex/ARF1/GTP/ER cargo protein -0.012 0.043 -10000 0 -0.19 29 29
CD4 -0.002 0.036 0.24 11 -0.31 1 12
CLTA -0.006 0 -10000 0 -10000 0 0
mol:GTP -0.002 0.005 -10000 0 -10000 0 0
ARFGAP1 -0.003 0 -10000 0 -10000 0 0
mol:PI-4-5-P2 -0.002 0.029 0.11 22 -10000 0 22
ARF1/GTP -0.013 0.038 -10000 0 -0.18 29 29
coatomer protein complex/ARF1/GTP/ARF-GAP1/ER cargo protein -0.012 0.037 -10000 0 -0.17 29 29
mol:Choline -0.002 0.028 0.11 22 -10000 0 22
mol:GDP 0 0 -10000 0 -10000 0 0
ARF1 -0.022 0.068 -10000 0 -0.32 29 29
DDEF1 -0.001 0.028 0.11 4 -10000 0 4
ARF1/GDP 0.001 0.007 -10000 0 -10000 0 0
AP2M1 -0.003 0.025 0.24 6 -10000 0 6
EntrezGene:1313 0 0 -10000 0 -10000 0 0
actin filament polymerization -0.013 0.034 -10000 0 -0.16 30 30
Rac/GTP -0.005 0.009 -10000 0 -0.22 1 1
ARF1/GTP/GGA3/ARF-GAP1 -0.014 0.031 -10000 0 -0.15 29 29
ARFIP2 -0.007 0.003 -10000 0 -10000 0 0
COPA -0.005 0.015 0.24 2 -10000 0 2
RAC1 -0.006 0.013 -10000 0 -0.31 1 1
ARF1/GTP/coatomer protein complex -0.008 0.04 -10000 0 -0.18 29 29
ARF1/GTP/ARHGAP10 -0.012 0.038 -10000 0 -0.18 29 29
GGA3 -0.006 0 -10000 0 -10000 0 0
ARF1/GTP/Membrin -0.005 0.035 -10000 0 -0.16 29 29
AP2A1 -0.024 0.073 -10000 0 -0.31 35 35
coatomer protein complex/ARF1/GTP/ARF-GAP1 -0.01 0.037 -10000 0 -0.17 29 29
ARF1/GDP/Membrin -0.004 0.033 -10000 0 -0.15 29 29
Arfaptin 2/Rac/GDP 0.005 0.008 -10000 0 -0.17 1 1
CYTH2 -0.002 0.005 -10000 0 -10000 0 0
ARF1/GTP/GGA3 -0.015 0.038 -10000 0 -0.18 29 29
mol:ATP 0 0 -10000 0 -10000 0 0
Rac/GDP -0.004 0.009 -10000 0 -0.21 1 1
mol:Brefeldin A 0 0 -10000 0 -10000 0 0
CD4/HIV Nef/AP2/vacuolar proton-transporting V-type ATPase complex/Coatomer protein complex/ARF1/GTP -0.016 0.053 -10000 0 -0.3 4 4
PLD2 -0.002 0.029 0.11 22 -10000 0 22
ARF-GAP1/v-SNARE -0.003 0 -10000 0 -10000 0 0
PIP5K1A -0.002 0.029 0.11 22 -10000 0 22
ARF1/GTP/Membrin/GBF1/p115 -0.011 0.035 -10000 0 -0.16 29 29
mol:Phosphatic acid 0 0 -10000 0 -10000 0 0
mol:Phosphatidic acid -0.002 0.028 0.11 22 -10000 0 22
KDEL Receptor/Ligand/ARF-GAP1 -0.003 0 -10000 0 -10000 0 0
GOSR2 0.001 0.014 -10000 0 -10000 0 0
USO1 0.002 0.025 0.13 6 -0.37 1 7
GBF1 0 0.026 -10000 0 -0.37 2 2
ARF1/GTP/Arfaptin 2 -0.015 0.038 -10000 0 -0.18 29 29
CD4/HIV Nef/AP2/vacuolar proton-transporting V-type ATPase complex 0.002 0.051 0.16 15 -0.18 34 49
EPO signaling pathway

Figure S110.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S110.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BCL2L1 -0.012 0.14 0.49 2 -0.48 2 4
CRKL -0.027 0.041 0.21 2 -10000 0 2
mol:DAG -0.036 0.067 0.27 2 -0.33 4 6
HRAS -0.027 0.041 0.22 1 -10000 0 1
MAPK8 -0.018 0.031 0.16 4 -0.17 12 16
RAP1A -0.027 0.041 0.21 2 -10000 0 2
GAB1 -0.028 0.041 0.21 2 -10000 0 2
MAPK14 -0.02 0.033 0.36 1 -0.17 15 16
EPO -0.01 0.009 -10000 0 -10000 0 0
PLCG1 -0.037 0.068 0.27 2 -0.34 4 6
EPOR/TRPC2/IP3 Receptors -0.01 0.014 0.26 1 -10000 0 1
RAPGEF1 -0.006 0 -10000 0 -10000 0 0
EPO/EPOR (dimer)/SOCS3 -0.012 0.019 0.17 3 -0.2 2 5
GAB1/SHC/GRB2/SOS1 -0.025 0.043 -10000 0 -10000 0 0
EPO/EPOR (dimer) -0.012 0.016 0.24 1 -10000 0 1
IRS2 -0.027 0.041 0.21 2 -10000 0 2
STAT1 0.029 0.12 0.4 2 -0.37 4 6
STAT5B -0.051 0.093 0.34 2 -0.39 7 9
cell proliferation -0.019 0.03 0.18 4 -0.16 12 16
GAB1/SHIP/PIK3R1/SHP2/SHC -0.058 0.06 -10000 0 -0.22 21 21
TEC -0.016 0.057 0.29 2 -10000 0 2
SOCS3 -0.006 0.023 0.24 2 -0.31 2 4
STAT1 (dimer) 0.029 0.12 0.39 2 -0.37 4 6
JAK2 -0.01 0.023 0.22 2 -0.31 2 4
PIK3R1 -0.075 0.13 -10000 0 -0.31 131 131
EPO/EPOR (dimer)/JAK2 -0.026 0.048 0.39 2 -10000 0 2
EPO/EPOR -0.012 0.016 0.24 1 -10000 0 1
LYN -0.017 0.049 -10000 0 -0.31 15 15
TEC/VAV2 -0.018 0.056 0.29 2 -10000 0 2
elevation of cytosolic calcium ion concentration -0.01 0.014 0.26 1 -10000 0 1
SHC1 -0.006 0 -10000 0 -10000 0 0
EPO/EPOR (dimer)/LYN -0.02 0.037 0.26 2 -0.19 15 17
mol:IP3 -0.036 0.067 0.27 2 -0.33 4 6
PI3K regualtory subunit polypeptide 1/IRS2/SHIP -0.056 0.064 0.14 1 -0.23 21 22
SH2B3 -0.01 0.007 -10000 0 -10000 0 0
NFKB1 -0.022 0.039 0.19 1 -0.21 17 18
EPO/EPOR (dimer)/JAK2/SOCS3 -0.003 0.016 -10000 0 -0.18 3 3
PTPN6 -0.026 0.043 0.22 2 -10000 0 2
TEC/VAV2/GRB2 -0.019 0.054 0.28 2 -10000 0 2
EPOR -0.01 0.014 0.26 1 -10000 0 1
INPP5D 0 0 -10000 0 -10000 0 0
mol:GDP -0.026 0.042 -10000 0 -10000 0 0
SOS1 0.005 0.05 0.24 24 -10000 0 24
PLCG2 -0.006 0 -10000 0 -10000 0 0
CRKL/CBL/C3G -0.029 0.039 0.22 2 -10000 0 2
VAV2 -0.028 0.042 0.21 2 -10000 0 2
CBL -0.027 0.041 0.21 2 -10000 0 2
SHC/Grb2/SOS1 -0.028 0.035 0.15 1 -10000 0 1
STAT5A -0.05 0.092 0.34 2 -0.25 63 65
GRB2 -0.006 0 -10000 0 -10000 0 0
STAT5 (dimer) -0.075 0.14 0.46 2 -0.36 95 97
LYN/PLCgamma2 -0.014 0.033 -10000 0 -0.21 15 15
PTPN11 -0.006 0 -10000 0 -10000 0 0
BTK -0.021 0.052 0.22 3 -10000 0 3
BCL2 -0.085 0.29 0.49 2 -0.72 93 95
Signaling events mediated by HDAC Class I

Figure S111.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S111.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
NF kappa B/RelA -0.002 0.054 -10000 0 -0.26 19 19
Ran/GTP/Exportin 1/HDAC1 -0.007 0.003 -10000 0 -10000 0 0
NF kappa B1 p50/RelA/I kappa B alpha -0.021 0.064 -10000 0 -0.31 20 20
SUMO1 -0.006 0 -10000 0 -10000 0 0
ZFPM1 -0.006 0 -10000 0 -10000 0 0
NPC/RanGAP1/SUMO1/Ubc9 -0.001 0.006 -10000 0 -10000 0 0
FKBP3 -0.001 0.034 0.24 11 -10000 0 11
Histones 0.007 0.059 0.28 7 -10000 0 7
YY1/LSF 0.003 0.054 0.17 38 -0.18 16 54
SMG5 -0.004 0.018 0.24 3 -10000 0 3
RAN -0.006 0 -10000 0 -10000 0 0
I kappa B alpha/HDAC3 -0.015 0.049 -10000 0 -0.21 28 28
I kappa B alpha/HDAC1 -0.005 0.062 0.16 31 -0.35 8 39
SAP18 -0.006 0.013 -10000 0 -0.31 1 1
RELA -0.012 0.048 -10000 0 -0.23 14 14
HDAC1/Smad7 0.018 0.036 0.16 36 -10000 0 36
RANGAP1 -0.006 0 -10000 0 -10000 0 0
HDAC3/TR2 -0.009 0.024 0.16 2 -10000 0 2
NuRD/MBD3 Complex 0.005 0.041 0.21 2 -10000 0 2
NF kappa B1 p50/RelA -0.014 0.049 -10000 0 -0.23 18 18
EntrezGene:23225 0 0 -10000 0 -10000 0 0
GATA2 -0.009 0.035 0.24 1 -0.31 7 8
GATA1 -0.006 0 -10000 0 -10000 0 0
Mad/Max -0.006 0.015 0.17 4 -10000 0 4
NuRD/MBD3 Complex/GATA1/Fog1 0.003 0.041 0.25 1 -10000 0 1
RBBP7 -0.007 0.018 -10000 0 -0.31 2 2
NPC 0.003 0.008 0.13 2 -10000 0 2
RBBP4 0.002 0.043 0.24 18 -10000 0 18
MAX -0.006 0 -10000 0 -10000 0 0
EntrezGene:9972 0 0 -10000 0 -10000 0 0
FBXW11 -0.006 0 -10000 0 -10000 0 0
NFKBIA -0.014 0.056 -10000 0 -0.34 13 13
KAT2B 0 0 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
SIN3/HDAC complex 0.007 0.04 0.19 12 -10000 0 12
SIN3 complex 0.011 0.009 0.15 1 -0.16 1 2
SMURF1 -0.006 0 -10000 0 -10000 0 0
CHD3 -0.011 0.04 -10000 0 -0.31 10 10
SAP30 -0.006 0 -10000 0 -10000 0 0
EntrezGene:23636 0 0 -10000 0 -10000 0 0
NCOR1 -0.007 0.018 -10000 0 -0.31 2 2
YY1/HDAC3 -0.011 0.032 -10000 0 -0.27 1 1
YY1/HDAC2 -0.005 0.037 0.17 11 -0.19 14 25
YY1/HDAC1 0.003 0.051 0.17 36 -0.19 13 49
NuRD/MBD2 Complex (MeCP1) 0.005 0.041 0.21 2 -10000 0 2
PPARG -0.012 0.049 -10000 0 -0.24 20 20
HDAC8/hEST1B 0.016 0.032 0.16 29 -10000 0 29
UBE2I -0.006 0 -10000 0 -10000 0 0
beta TrCP1/SCF ubiquitin ligase complex -0.006 0 -10000 0 -10000 0 0
TNFRSF1A -0.016 0.054 -10000 0 -0.31 19 19
HDAC3/SMRT (N-CoR2) -0.011 0.028 -10000 0 -10000 0 0
MBD3L2 -0.006 0 -10000 0 -10000 0 0
ubiquitin-dependent protein catabolic process 0.018 0.036 0.16 36 -10000 0 36
CREBBP -0.012 0.042 -10000 0 -0.31 11 11
NuRD/MBD3/MBD3L2 Complex 0.003 0.043 0.21 3 -10000 0 3
HDAC1 0.01 0.06 0.24 36 -10000 0 36
HDAC3 -0.008 0.025 -10000 0 -10000 0 0
HDAC2 -0.002 0.036 0.24 11 -0.31 1 12
YY1 -0.006 0.032 -10000 0 -0.22 13 13
HDAC8 0.006 0.052 0.24 26 -10000 0 26
SMAD7 -0.006 0 -10000 0 -10000 0 0
NCOR2 -0.011 0.038 -10000 0 -0.31 9 9
MXD1 -0.004 0.021 0.24 4 -10000 0 4
STAT3 -0.012 0.05 -10000 0 -0.26 22 22
NFKB1 -0.01 0.033 -10000 0 -0.31 7 7
EntrezGene:8021 0 0 -10000 0 -10000 0 0
RANBP2 -0.005 0.015 0.24 2 -10000 0 2
YY1/LSF/HDAC1 0.01 0.067 0.17 66 -0.17 13 79
YY1/SAP30/HDAC1 0.001 0.047 0.15 36 -0.17 13 49
EP300 -0.007 0.018 -10000 0 -0.31 2 2
STAT3 (dimer non-phopshorylated) -0.012 0.05 -10000 0 -0.25 22 22
proteasomal ubiquitin-dependent protein catabolic process -0.014 0.056 -10000 0 -0.34 13 13
histone deacetylation 0.005 0.04 0.21 2 -10000 0 2
STAT3 (dimer non-phopshorylated)/HDAC3 -0.015 0.042 -10000 0 -0.34 2 2
nuclear export -0.016 0.032 -10000 0 -0.16 29 29
PRKACA -0.006 0 -10000 0 -10000 0 0
GATAD2B -0.006 0.013 -10000 0 -0.31 1 1
GATAD2A -0.005 0.01 0.24 1 -10000 0 1
GATA2/HDAC3 -0.011 0.028 0.16 1 -10000 0 1
GATA1/HDAC1 0.004 0.043 0.17 36 -10000 0 36
GATA1/HDAC3 -0.009 0.022 -10000 0 -10000 0 0
CHD4 -0.005 0.01 0.24 1 -10000 0 1
TNF-alpha/TNFR1A -0.013 0.038 0.17 1 -0.21 19 20
SIN3/HDAC complex/Mad/Max 0.008 0.037 0.21 4 -10000 0 4
NuRD Complex 0.003 0.043 0.21 3 -10000 0 3
positive regulation of chromatin silencing 0.007 0.057 0.27 7 -10000 0 7
SIN3B -0.005 0.01 0.24 1 -10000 0 1
MTA2 -0.006 0 -10000 0 -10000 0 0
SIN3A -0.006 0 -10000 0 -10000 0 0
XPO1 0.014 0.068 0.24 46 -10000 0 46
SUMO1/HDAC1 0.014 0.036 0.15 36 -10000 0 36
HDAC complex 0.026 0.054 0.29 11 -0.16 3 14
GATA1/Fog1 -0.007 0 -10000 0 -10000 0 0
FKBP25/HDAC1/HDAC2 0.023 0.043 0.16 53 -10000 0 53
TNF -0.005 0.01 0.24 1 -10000 0 1
negative regulation of cell growth 0.008 0.037 0.18 13 -10000 0 13
NuRD/MBD2/PRMT5 Complex 0.005 0.041 0.21 2 -10000 0 2
Ran/GTP/Exportin 1 0.007 0.039 0.14 46 -10000 0 46
NF kappa B/RelA/I kappa B alpha -0.018 0.061 -10000 0 -0.3 20 20
SIN3/HDAC complex/NCoR1 0.007 0.039 0.19 12 -10000 0 12
TFCP2 0.009 0.066 0.24 38 -0.31 3 41
NR2C1 -0.005 0.015 0.24 2 -10000 0 2
MBD3 -0.006 0 -10000 0 -10000 0 0
MBD2 -0.006 0 -10000 0 -10000 0 0
Nephrin/Neph1 signaling in the kidney podocyte

Figure S112.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S112.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
positive regulation of NF-kappaB transcription factor activity 0.006 0.036 0.25 1 -0.16 21 22
KIRREL -0.003 0.044 0.22 19 -0.34 1 20
Nephrin/NEPH1Par3/Par6/Atypical PKCs -0.006 0.036 0.16 21 -0.26 1 22
PLCG1 -0.004 0.023 0.24 5 -10000 0 5
ARRB2 -0.006 0 -10000 0 -10000 0 0
WASL -0.006 0 -10000 0 -10000 0 0
Nephrin/NEPH1/podocin/CD2AP 0.009 0.034 0.17 6 -0.18 1 7
ChemicalAbstracts:57-88-5 0 0 -10000 0 -10000 0 0
Nephrin/NEPH1/podocin/NCK1-2/N-WASP 0.005 0.037 0.2 1 -0.21 1 2
FYN -0.003 0.025 0.11 20 -0.28 1 21
mol:Ca2+ 0.008 0.034 0.16 7 -0.2 1 8
mol:DAG 0.009 0.034 0.16 7 -0.2 1 8
NPHS2 -0.009 0.01 -10000 0 -10000 0 0
mol:IP3 0.009 0.034 0.16 7 -0.2 1 8
regulation of endocytosis -0.017 0.044 0.13 19 -0.26 1 20
Nephrin/NEPH1/podocin/Cholesterol 0.006 0.032 0.14 21 -0.2 1 22
establishment of cell polarity -0.006 0.036 0.16 21 -0.25 1 22
Nephrin/NEPH1/podocin/NCK1-2 0.021 0.048 0.17 8 -0.18 1 9
Nephrin/NEPH1/beta Arrestin2 -0.017 0.045 0.13 19 -0.27 1 20
NPHS1 -0.008 0.019 0.22 3 -10000 0 3
Nephrin/NEPH1/podocin -0.004 0.05 0.14 19 -0.28 1 20
TJP1 -0.005 0.019 0.24 2 -0.31 1 3
NCK1 0.012 0.065 0.24 42 -10000 0 42
NCK2 -0.006 0 -10000 0 -10000 0 0
heterophilic cell adhesion 0 0 -10000 0 -10000 0 0
Nephrin/NEPH1/podocin/PLCgamma1 0.009 0.035 0.17 7 -0.2 1 8
CD2AP -0.004 0.026 0.24 5 -0.31 1 6
Nephrin/NEPH1/podocin/GRB2 0.008 0.033 0.18 3 -0.2 1 4
GRB2 -0.006 0 -10000 0 -10000 0 0
homophilic cell adhesion 0 0 -10000 0 -10000 0 0
TRPC6 -0.008 0.028 0.15 4 -0.18 1 5
cytoskeleton organization -0.001 0.036 0.22 1 -0.22 1 2
Nephrin/NEPH1 0.006 0.028 0.13 21 -0.17 1 22
Nephrin/NEPH1/ZO-1 -0.007 0.033 0.14 21 -0.2 2 23
Signaling events mediated by HDAC Class III

Figure S113.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S113.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
EP300 -0.007 0.018 -10000 0 -0.31 2 2
HDAC4 -0.006 0 -10000 0 -10000 0 0
induction of apoptosis 0 0 -10000 0 -10000 0 0
regulation of S phase of mitotic cell cycle 0.001 0.019 -10000 0 -0.12 14 14
CDKN1A -0.005 0.093 -10000 0 -0.52 16 16
KAT2B 0 0 -10000 0 -10000 0 0
BAX -0.006 0 -10000 0 -10000 0 0
FOXO3 0 0.026 0.3 2 -0.16 8 10
FOXO1 -0.009 0.031 -10000 0 -0.31 6 6
FOXO4 -0.006 0.032 -10000 0 -0.22 13 13
response to UV 0 0 -10000 0 -10000 0 0
XRCC6 -0.006 0 -10000 0 -10000 0 0
TAT -0.006 0 -10000 0 -10000 0 0
mol:Lysophosphatidic acid 0 0 -10000 0 -10000 0 0
MYOD1 -0.003 0 -10000 0 -10000 0 0
PPARGC1A -0.003 0.025 0.24 6 -10000 0 6
FHL2 -0.005 0.015 0.24 2 -10000 0 2
response to nutrient levels 0 0 -10000 0 -10000 0 0
KU70/SIRT1 -0.004 0.02 -10000 0 -10000 0 0
HIST2H4A -0.001 0.019 0.12 14 -10000 0 14
SIRT1/FOXO3a -0.002 0.027 0.21 2 -10000 0 2
SIRT1 -0.003 0.027 0.16 14 -10000 0 14
response to hypoxia 0 0 -10000 0 -10000 0 0
SIRT1/MEF2D/HDAC4 0.009 0.018 -10000 0 -10000 0 0
SIRT1/Histone H1b -0.004 0.036 -10000 0 -0.19 13 13
apoptosis 0.006 0.019 -10000 0 -10000 0 0
SIRT1/PGC1A -0.001 0.024 0.12 20 -10000 0 20
p53/SIRT1 -0.031 0.092 0.32 15 -0.22 83 98
SIRT1/FOXO4 -0.005 0.034 -10000 0 -0.19 13 13
FOXO1/FHL2/SIRT1 0.01 0.024 0.15 2 -0.16 5 7
HIST1H1E -0.005 0.036 -10000 0 -0.22 13 13
SIRT1/p300 -0.005 0.024 -10000 0 -0.21 2 2
muscle cell differentiation 0.003 0.018 -10000 0 -0.11 14 14
TP53 -0.047 0.11 0.17 15 -0.31 83 98
KU70/SIRT1/BAX 0.009 0.018 -10000 0 -10000 0 0
CREBBP -0.012 0.042 -10000 0 -0.31 11 11
MEF2D -0.006 0 -10000 0 -10000 0 0
HIV-1 Tat/SIRT1 -0.004 0.02 -10000 0 -10000 0 0
ACSS2 -0.005 0.022 -10000 0 -0.21 1 1
SIRT1/PCAF/MYOD -0.003 0.018 0.11 14 -10000 0 14
VEGFR1 specific signals

Figure S114.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S114.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
VEGFR1 homodimer/VEGFB homodimer -0.015 0.034 -10000 0 -10000 0 0
VEGFR1 homodimer/NRP1 -0.006 0.012 -10000 0 -10000 0 0
mol:DAG -0.009 0.019 -10000 0 -10000 0 0
VEGFR1 homodimer/NRP1/VEGFR 121 0.006 0.046 -10000 0 -10000 0 0
CaM/Ca2+ -0.013 0.026 -10000 0 -10000 0 0
HIF1A -0.01 0.022 -10000 0 -0.31 3 3
GAB1 -0.007 0.018 -10000 0 -0.31 2 2
AKT1 -0.025 0.089 -10000 0 -0.3 2 2
PLCG1 -0.009 0.019 -10000 0 -10000 0 0
NOS3 -0.015 0.046 -10000 0 -10000 0 0
CBL -0.006 0 -10000 0 -10000 0 0
mol:NO -0.015 0.045 -10000 0 -10000 0 0
FLT1 -0.008 0.015 -10000 0 -10000 0 0
PGF -0.006 0.013 -10000 0 -0.31 1 1
VEGFR1 homodimer/NRP2/VEGFR121 0.012 0.059 0.3 3 -10000 0 3
CALM1 -0.012 0.042 -10000 0 -0.31 11 11
PIK3CA 0.047 0.1 0.24 122 -10000 0 122
eNOS/Hsp90 -0.016 0.045 -10000 0 -10000 0 0
endothelial cell proliferation -0.011 0.028 0.22 1 -10000 0 1
mol:Ca2+ -0.009 0.019 -10000 0 -10000 0 0
MAPK3 -0.015 0.034 0.24 1 -0.28 1 2
MAPK1 -0.012 0.027 0.24 1 -10000 0 1
PIK3R1 -0.075 0.13 -10000 0 -0.31 131 131
PLGF homodimer -0.006 0.013 -10000 0 -0.31 1 1
PRKACA -0.006 0 -10000 0 -10000 0 0
RP11-342D11.1 0 0 -10000 0 -10000 0 0
CAV1 -0.053 0.11 0.24 2 -0.31 90 92
VEGFA homodimer 0.015 0.069 0.24 49 -10000 0 49
VEGFR1 homodimer/VEGFA homodimer 0.006 0.051 -10000 0 -10000 0 0
platelet activating factor biosynthetic process -0.016 0.033 0.23 1 -0.27 1 2
PI3K -0.012 0.091 -10000 0 -0.29 2 2
PRKCA -0.01 0.027 0.27 1 -10000 0 1
PRKCB -0.008 0.017 -10000 0 -10000 0 0
VEGFR1 homodimer/PLGF homodimer -0.009 0.014 -10000 0 -10000 0 0
VEGFA 0.016 0.069 0.24 49 -10000 0 49
VEGFB -0.017 0.057 -10000 0 -0.31 21 21
mol:IP3 -0.009 0.019 -10000 0 -10000 0 0
RASA1 -0.017 0.032 -10000 0 -10000 0 0
NRP2 0.006 0.054 0.24 28 -10000 0 28
VEGFR1 homodimer -0.008 0.015 -10000 0 -10000 0 0
VEGFB homodimer -0.017 0.057 -10000 0 -0.31 21 21
NCK1 0.012 0.065 0.24 42 -10000 0 42
eNOS/Caveolin-1 -0.033 0.069 -10000 0 -0.36 3 3
PTPN11 -0.006 0 -10000 0 -10000 0 0
mol:PI-3-4-5-P3 -0.012 0.09 -10000 0 -0.29 2 2
mol:L-citrulline -0.015 0.045 -10000 0 -10000 0 0
VEGFR1 homodimer/VEGFA homodimer/CBL/CD2AP 0.003 0.049 0.29 1 -10000 0 1
VEGFR1 homodimer/VEGFA homodimer/NCK1 0.016 0.064 0.3 4 -10000 0 4
CD2AP -0.004 0.026 0.24 5 -0.31 1 6
PI3K/GAB1 -0.014 0.088 -10000 0 -0.28 2 2
PDPK1 -0.017 0.078 -10000 0 -0.27 2 2
VEGFR1 homodimer/VEGFA homodimer/SHP2 0.004 0.047 -10000 0 -10000 0 0
mol:NADP -0.015 0.045 -10000 0 -10000 0 0
HSP90AA1 -0.006 0.013 -10000 0 -0.31 1 1
ubiquitin-dependent protein catabolic process 0.003 0.048 0.28 1 -10000 0 1
VEGFR1 homodimer/NRP2 0 0.04 -10000 0 -10000 0 0
Sphingosine 1-phosphate (S1P) pathway

Figure S115.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S115.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
SPHK2 -0.006 0 -10000 0 -10000 0 0
SPHK1 -0.005 0.01 0.24 1 -10000 0 1
GNAI2 -0.006 0 -10000 0 -10000 0 0
mol:S1P 0.001 0.017 0.14 9 -10000 0 9
GNAO1 -0.004 0.028 0.24 6 -0.31 1 7
mol:Sphinganine-1-P -0.007 0.009 0.2 1 -10000 0 1
growth factor activity 0 0 -10000 0 -10000 0 0
S1P/S1P2/G12/G13 -0.004 0.013 -10000 0 -0.14 1 1
GNAI3 0.036 0.093 0.24 96 -10000 0 96
G12/G13 -0.007 0.009 -10000 0 -0.21 1 1
S1PR3 0 0 -10000 0 -10000 0 0
S1PR2 0 0 -10000 0 -10000 0 0
EDG1 -0.009 0.031 -10000 0 -0.31 6 6
S1P1/S1P -0.004 0.021 -10000 0 -0.17 6 6
S1PR5 0 0 -10000 0 -10000 0 0
S1PR4 0 0 -10000 0 -10000 0 0
GNAI1 -0.005 0.041 0.24 8 -0.31 5 13
S1P/S1P5/G12 -0.003 0 -10000 0 -10000 0 0
S1P/S1P3/Gq -0.019 0.066 -10000 0 -0.3 12 12
S1P/S1P4/Gi 0.014 0.043 0.18 2 -0.18 6 8
GNAQ -0.012 0.043 -10000 0 -0.31 12 12
GNAZ -0.008 0.025 -10000 0 -0.31 4 4
GNA14 -0.005 0.015 0.24 2 -10000 0 2
GNA15 -0.006 0.016 0.24 1 -0.31 1 2
GNA12 -0.006 0 -10000 0 -10000 0 0
GNA13 -0.006 0.013 -10000 0 -0.31 1 1
GNA11 -0.034 0.088 -10000 0 -0.31 53 53
ABCC1 -0.002 0.029 0.24 8 -10000 0 8
Hedgehog signaling events mediated by Gli proteins

Figure S116.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S116.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
HDAC1 0.011 0.06 0.24 36 -10000 0 36
HDAC2 -0.001 0.037 0.24 11 -0.31 1 12
GNB1/GNG2 0.007 0.012 0.16 1 -0.19 1 2
forebrain development -0.007 0.077 -10000 0 -0.43 7 7
GNAO1 -0.004 0.028 0.24 6 -0.31 1 7
SMO/beta Arrestin2 -0.008 0.004 -10000 0 -10000 0 0
SMO -0.007 0.003 -10000 0 -10000 0 0
ARRB2 -0.006 0.002 -10000 0 -10000 0 0
GLI3/SPOP -0.004 0.046 -10000 0 -0.23 12 12
mol:GTP -0.001 0.002 -10000 0 -10000 0 0
GSK3B -0.006 0 -10000 0 -10000 0 0
GNAI2 -0.006 0.002 -10000 0 -10000 0 0
SIN3/HDAC complex 0.012 0.01 0.15 1 -0.16 1 2
GNAI1 -0.006 0.041 0.24 8 -0.31 5 13
XPO1 0.013 0.067 0.24 46 -10000 0 46
GLI1/Su(fu) -0.013 0.068 -10000 0 -0.42 6 6
SAP30 -0.005 0.003 -10000 0 -10000 0 0
mol:GDP -0.007 0.003 -10000 0 -10000 0 0
MIM/GLI2A -0.01 0.035 0.24 6 -10000 0 6
IFT88 -0.015 0.053 -10000 0 -0.31 18 18
GNAI3 0.035 0.093 0.24 96 -10000 0 96
GLI2 -0.002 0.005 -10000 0 -10000 0 0
GLI3 -0.007 0.047 -10000 0 -0.24 12 12
CSNK1D -0.006 0 -10000 0 -10000 0 0
CSNK1E -0.006 0 -10000 0 -10000 0 0
SAP18 -0.005 0.013 -10000 0 -0.31 1 1
embryonic digit morphogenesis -0.015 0.053 -10000 0 -0.31 18 18
GNG2 -0.005 0.01 0.24 1 -10000 0 1
Gi family/GTP 0.009 0.043 0.18 1 -10000 0 1
SIN3B -0.004 0.011 0.24 1 -10000 0 1
SIN3A -0.005 0.003 -10000 0 -10000 0 0
GLI3/Su(fu) -0.009 0.042 -10000 0 -0.33 1 1
GLI2/Su(fu) -0.005 0.009 0.19 1 -10000 0 1
FOXA2 -0.056 0.22 -10000 0 -0.9 36 36
neural tube patterning -0.007 0.077 -10000 0 -0.43 7 7
SPOP -0.006 0 -10000 0 -10000 0 0
Su(fu)/PIAS1 -0.006 0.01 0.16 1 -10000 0 1
GNB1 -0.006 0.013 -10000 0 -0.31 1 1
CSNK1G2 -0.006 0 -10000 0 -10000 0 0
CSNK1G3 -0.006 0 -10000 0 -10000 0 0
MTSS1 -0.01 0.035 0.24 6 -10000 0 6
embryonic limb morphogenesis -0.007 0.077 -10000 0 -0.43 7 7
SUFU -0.005 0.008 -10000 0 -10000 0 0
LGALS3 -0.032 0.086 -10000 0 -0.31 50 50
catabolic process -0.007 0.037 -10000 0 -0.28 1 1
GLI3A/CBP -0.015 0.042 -10000 0 -0.31 11 11
KIF3A -0.005 0.015 0.24 2 -10000 0 2
GLI1 -0.007 0.078 -10000 0 -0.44 7 7
RAB23 -0.006 0 -10000 0 -10000 0 0
CSNK1A1 -0.005 0.015 0.24 2 -10000 0 2
IFT172 -0.007 0.018 -10000 0 -0.31 2 2
RBBP7 -0.006 0.018 -10000 0 -0.31 2 2
Su(fu)/Galectin3 -0.02 0.043 -10000 0 -0.18 1 1
GNAZ -0.009 0.025 -10000 0 -0.31 4 4
RBBP4 0.003 0.043 0.24 18 -10000 0 18
CSNK1G1 -0.006 0 -10000 0 -10000 0 0
PIAS1 -0.005 0.01 0.24 1 -10000 0 1
PRKACA -0.006 0 -10000 0 -10000 0 0
GLI2/SPOP -0.004 0.005 -10000 0 -10000 0 0
STK36 -0.007 0.011 0.24 1 -10000 0 1
Gi family/GNB1/GNG2/GDP 0.011 0.043 0.27 1 -10000 0 1
PTCH1 -0.015 0.13 -10000 0 -0.99 8 8
MIM/GLI1 -0.02 0.11 -10000 0 -0.41 30 30
CREBBP -0.015 0.042 -10000 0 -0.31 11 11
Su(fu)/SIN3/HDAC complex 0.009 0.038 0.18 12 -10000 0 12
S1P5 pathway

Figure S117.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S117.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
mol:S1P 0 0 -10000 0 -10000 0 0
telencephalon oligodendrocyte cell migration -0.009 0.038 -10000 0 -10000 0 0
GNAI2 -0.006 0 -10000 0 -10000 0 0
S1P/S1P5/G12 0.003 0 -10000 0 -10000 0 0
mol:GDP 0 0 -10000 0 -10000 0 0
GNAO1 -0.004 0.028 0.24 6 -0.31 1 7
RhoA/GTP 0.009 0.038 -10000 0 -10000 0 0
negative regulation of cAMP metabolic process 0.014 0.043 0.18 2 -0.17 6 8
GNAZ -0.008 0.025 -10000 0 -0.31 4 4
GNAI3 0.036 0.093 0.24 96 -10000 0 96
GNA12 -0.006 0 -10000 0 -10000 0 0
S1PR5 0 0 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
S1P/S1P5/Gi 0.014 0.043 0.18 2 -0.17 6 8
RhoA/GDP -0.004 0.012 -10000 0 -0.21 2 2
RHOA -0.007 0.018 -10000 0 -0.31 2 2
GNAI1 -0.005 0.041 0.24 8 -0.31 5 13
Angiopoietin receptor Tie2-mediated signaling

Figure S118.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S118.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
AKT1 -0.028 0.097 0.77 2 -10000 0 2
NCK1/PAK1/Dok-R -0.028 0.043 -10000 0 -10000 0 0
NCK1/Dok-R 0.003 0.05 -10000 0 -10000 0 0
PIK3CA 0.047 0.1 0.24 122 -10000 0 122
mol:beta2-estradiol -0.001 0.018 -10000 0 -0.16 7 7
RELA -0.006 0.013 -10000 0 -0.31 1 1
SHC1 -0.003 0.006 -10000 0 -10000 0 0
Rac/GDP -0.004 0.009 -10000 0 -0.21 1 1
F2 0.003 0.027 0.25 1 -0.19 7 8
TNIP2 -0.005 0.01 0.24 1 -10000 0 1
NF kappa B/RelA -0.014 0.027 -10000 0 -10000 0 0
FN1 0.075 0.13 0.24 200 -0.31 12 212
PLD2 -0.005 0.044 0.72 1 -10000 0 1
PTPN11 -0.006 0 -10000 0 -10000 0 0
GRB14 0.006 0.052 0.24 26 -10000 0 26
ELK1 -0.009 0.043 0.65 1 -10000 0 1
GRB7 -0.006 0.03 0.24 4 -0.31 3 7
PAK1 0.002 0.043 0.24 18 -10000 0 18
Tie2/Ang1/alpha5/beta1 Integrin 0.041 0.088 0.41 1 -10000 0 1
CDKN1A -0.031 0.14 0.77 2 -0.74 16 18
ITGA5 -0.003 0.025 0.24 6 -10000 0 6
mol:GTP 0 0 -10000 0 -10000 0 0
RasGAP/Dok-R -0.009 0.033 -10000 0 -10000 0 0
CRK -0.005 0.01 0.24 1 -10000 0 1
mol:NO -0.026 0.087 0.56 4 -10000 0 4
PLG -0.009 0.048 0.72 1 -10000 0 1
mol:GDP 0 0 -10000 0 -10000 0 0
chemokinesis -0.012 0.078 0.69 2 -10000 0 2
GRB2 -0.006 0 -10000 0 -10000 0 0
PIK3R1 -0.075 0.13 -10000 0 -0.31 131 131
ANGPT2 -0.005 0.07 0.58 6 -10000 0 6
BMX -0.005 0.044 0.72 1 -10000 0 1
ANGPT1 0.003 0.051 0.42 7 -10000 0 7
tube development -0.036 0.1 0.56 6 -10000 0 6
ANGPT4 -0.006 0.005 -10000 0 -10000 0 0
response to hypoxia -0.001 0.006 0.11 1 -10000 0 1
Tie2/Ang1/GRB14 0.002 0.054 0.65 1 -10000 0 1
alpha5/beta1 Integrin -0.003 0.025 0.17 12 -10000 0 12
FGF2 -0.011 0.04 -10000 0 -0.31 10 10
STAT5A (dimer) -0.031 0.12 0.77 2 -0.65 2 4
mol:L-citrulline -0.026 0.087 0.56 4 -10000 0 4
AGTR1 -0.005 0.007 -10000 0 -10000 0 0
MAPK14 -0.006 0.056 0.84 1 -10000 0 1
Tie2/SHP2 -0.007 0.027 -10000 0 -10000 0 0
TEK -0.004 0.044 0.73 1 -10000 0 1
RPS6KB1 -0.024 0.095 0.72 2 -10000 0 2
Angiotensin II/AT1 -0.002 0.015 0.14 6 -10000 0 6
Tie2/Ang1/GRB2 -0.006 0.042 0.65 1 -10000 0 1
MAPK3 -0.011 0.046 0.66 1 -10000 0 1
MAPK1 -0.007 0.042 0.66 1 -10000 0 1
Tie2/Ang1/GRB7 -0.007 0.03 -10000 0 -10000 0 0
NFKB1 -0.01 0.033 -10000 0 -0.31 7 7
MAPK8 -0.004 0.046 0.72 1 -10000 0 1
PI3K -0.026 0.099 0.76 2 -10000 0 2
FES -0.007 0.057 0.85 1 -10000 0 1
Crk/Dok-R -0.008 0.032 -10000 0 -10000 0 0
Tie2/Ang1/ABIN2 -0.005 0.042 0.65 1 -10000 0 1
blood circulation 0 0 -10000 0 -10000 0 0
negative regulation of caspase activity -0.027 0.094 0.76 2 -10000 0 2
STAT5A -0.01 0.036 -10000 0 -0.31 8 8
mol:ROS 0 0 -10000 0 -10000 0 0
PTK2 -0.021 0.099 0.72 2 -10000 0 2
Tie2/Ang2 -0.023 0.1 0.83 2 -10000 0 2
Tie2/Ang1 -0.003 0.049 0.83 1 -10000 0 1
FOXO1 -0.031 0.097 0.78 2 -10000 0 2
ELF1 -0.008 0.027 0.2 1 -0.31 4 5
ELF2 -0.003 0.047 0.8 1 -10000 0 1
mol:Choline -0.005 0.044 0.72 1 -10000 0 1
cell migration -0.016 0.026 -10000 0 -10000 0 0
FYN -0.039 0.1 0.62 4 -10000 0 4
DOK2 -0.005 0.01 0.24 1 -10000 0 1
negative regulation of cell cycle -0.028 0.13 0.56 5 -0.66 16 21
ETS1 -0.001 0.037 0.22 15 -10000 0 15
PXN -0.022 0.094 0.69 2 -10000 0 2
ITGB1 -0.003 0.025 0.24 6 -10000 0 6
NOS3 -0.028 0.091 0.73 2 -10000 0 2
RAC1 -0.006 0.013 -10000 0 -0.31 1 1
TNF -0.004 0.021 0.19 3 -10000 0 3
MAPKKK cascade -0.005 0.044 0.72 1 -10000 0 1
RASA1 -0.007 0.022 -10000 0 -0.31 3 3
Tie2/Ang1/Shc -0.004 0.044 0.69 1 -10000 0 1
NCK1 0.012 0.065 0.24 42 -10000 0 42
vasculogenesis -0.024 0.084 0.49 6 -10000 0 6
mol:Phosphatidic acid -0.005 0.044 0.72 1 -10000 0 1
mol:Angiotensin II 0 0.006 -10000 0 -10000 0 0
mol:NADP -0.026 0.087 0.56 4 -10000 0 4
Rac1/GTP -0.032 0.07 -10000 0 -10000 0 0
MMP2 -0.015 0.073 0.72 1 -10000 0 1
Signaling events mediated by HDAC Class II

Figure S119.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S119.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
G beta1gamma2/HDAC5 0.01 0.019 -10000 0 -0.16 6 6
HDAC3 -0.006 0 -10000 0 -10000 0 0
Ran/GTP/Exportin 1/HDAC4 -0.007 0.002 -10000 0 -10000 0 0
GATA1/HDAC4 -0.007 0 -10000 0 -10000 0 0
GATA1/HDAC5 -0.009 0.019 -10000 0 -0.21 5 5
GATA2/HDAC5 -0.011 0.03 0.17 1 -0.21 12 13
HDAC5/BCL6/BCoR 0.003 0.034 0.16 1 -0.18 19 20
HDAC9 0.004 0.048 0.24 22 -10000 0 22
Glucocorticoid receptor/Hsp90/HDAC6 0.006 0.029 0.16 5 -0.18 11 16
HDAC4/ANKRA2 -0.007 0.011 0.17 1 -0.21 1 2
HDAC5/YWHAB -0.008 0.021 0.17 1 -0.21 5 6
NPC/RanGAP1/SUMO1/Ubc9 -0.001 0.006 -10000 0 -10000 0 0
GATA2 -0.009 0.035 0.24 1 -0.31 7 8
HDAC4/RFXANK -0.006 0.01 0.17 2 -10000 0 2
BCOR -0.005 0.01 0.24 1 -10000 0 1
mol:GTP 0 0 -10000 0 -10000 0 0
HDAC10 -0.006 0 -10000 0 -10000 0 0
HDAC5 -0.008 0.028 -10000 0 -0.31 5 5
GNB1/GNG2 -0.007 0.011 0.17 1 -0.21 1 2
Histones 0 0.026 0.18 1 -0.18 4 5
ADRBK1 -0.006 0 -10000 0 -10000 0 0
HDAC4 -0.006 0 -10000 0 -10000 0 0
XPO1 0.014 0.068 0.24 46 -10000 0 46
HDAC5/ANKRA2 -0.009 0.022 0.17 1 -0.21 6 7
HDAC4/Ubc9 -0.007 0 -10000 0 -10000 0 0
HDAC7 0 0 -10000 0 -10000 0 0
HDAC5/14-3-3 E -0.009 0.021 -10000 0 -0.21 6 6
TUBA1B -0.006 0 -10000 0 -10000 0 0
HDAC6 -0.004 0.023 0.24 5 -10000 0 5
HDAC5/RFXANK -0.008 0.022 0.17 2 -0.21 5 7
CAMK4 -0.002 0.031 0.24 9 -10000 0 9
Tubulin/HDAC6 0.01 0.015 0.16 6 -10000 0 6
SUMO1 -0.006 0 -10000 0 -10000 0 0
EntrezGene:9972 0 0 -10000 0 -10000 0 0
YWHAB -0.005 0.01 0.24 1 -10000 0 1
GATA1 -0.006 0 -10000 0 -10000 0 0
EntrezGene:8021 0 0 -10000 0 -10000 0 0
YWHAE -0.006 0.013 -10000 0 -0.31 1 1
NR3C1 -0.011 0.04 -10000 0 -0.31 10 10
SUMO1/HDAC4 0.005 0 -10000 0 -10000 0 0
SRF -0.007 0.022 -10000 0 -0.31 3 3
HDAC4/YWHAB -0.007 0.007 0.17 1 -10000 0 1
Tubulin -0.007 0.007 0.17 1 -10000 0 1
HDAC4/14-3-3 E -0.007 0.009 -10000 0 -0.21 1 1
GNB1 -0.006 0.013 -10000 0 -0.31 1 1
RANGAP1 -0.006 0 -10000 0 -10000 0 0
BCL6/BCoR -0.012 0.033 0.17 1 -0.21 14 15
HDAC4/HDAC3/SMRT (N-CoR2) 0.006 0.023 -10000 0 -0.18 9 9
HDAC4/SRF 0.01 0.023 0.16 9 -0.18 3 12
HDAC4/ER alpha -0.034 0.069 -10000 0 -0.21 75 75
EntrezGene:23225 0 0 -10000 0 -10000 0 0
positive regulation of chromatin silencing 0 0.026 0.18 1 -0.18 4 5
cell motility 0.01 0.015 0.16 6 -10000 0 6
EntrezGene:23636 0 0 -10000 0 -10000 0 0
UBE2I -0.006 0 -10000 0 -10000 0 0
HDAC7/HDAC3 -0.003 0 -10000 0 -10000 0 0
BCL6 -0.013 0.047 -10000 0 -0.31 14 14
HDAC4/CaMK II delta B -0.006 0 -10000 0 -10000 0 0
Hsp90/HDAC6 -0.006 0.019 0.17 5 -0.21 1 6
ESR1 -0.046 0.1 -10000 0 -0.31 75 75
HDAC6/HDAC11 -0.005 0.017 0.17 5 -10000 0 5
Ran/GTP/Exportin 1 0.007 0.039 0.14 46 -10000 0 46
NPC 0.003 0.008 0.13 2 -10000 0 2
MEF2C -0.017 0.057 -10000 0 -0.31 21 21
RAN -0.006 0 -10000 0 -10000 0 0
HDAC4/MEF2C 0.004 0.037 -10000 0 -0.15 30 30
GNG2 -0.005 0.01 0.24 1 -10000 0 1
NCOR2 -0.011 0.038 -10000 0 -0.31 9 9
TUBB2A -0.005 0.01 0.24 1 -10000 0 1
HDAC11 -0.006 0 -10000 0 -10000 0 0
HSP90AA1 -0.006 0.013 -10000 0 -0.31 1 1
RANBP2 -0.005 0.015 0.24 2 -10000 0 2
ANKRA2 -0.006 0.016 0.24 1 -0.31 1 2
RFXANK -0.005 0.015 0.24 2 -10000 0 2
nuclear import 0.007 0.022 0.21 6 -10000 0 6
Class I PI3K signaling events mediated by Akt

Figure S120.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S120.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
BCL2L1 -0.007 0.009 0.2 1 -10000 0 1
BAD/BCL-XL/YWHAZ -0.009 0.006 0.13 1 -10000 0 1
CDKN1B 0.018 0.05 0.25 1 -10000 0 1
CDKN1A 0.014 0.052 -10000 0 -10000 0 0
FRAP1 -0.006 0 -10000 0 -10000 0 0
PRKDC 0.036 0.093 0.24 97 -10000 0 97
FOXO3 0.016 0.051 -10000 0 -10000 0 0
AKT1 0.021 0.051 -10000 0 -10000 0 0
BAD -0.006 0 -10000 0 -10000 0 0
AKT3 -0.14 0.12 0.16 4 -0.24 323 327
mol:GTP 0 0 -10000 0 -10000 0 0
FOXO4 0.018 0.048 -10000 0 -10000 0 0
AKT1/ASK1 0.016 0.046 -10000 0 -10000 0 0
BAD/YWHAZ 0.009 0 -10000 0 -10000 0 0
RICTOR -0.003 0.025 0.24 6 -10000 0 6
RAF1 -0.006 0 -10000 0 -10000 0 0
JNK cascade 0.003 0.012 -10000 0 -10000 0 0
TSC1 0.017 0.048 -10000 0 -10000 0 0
YWHAZ -0.006 0 -10000 0 -10000 0 0
AKT1/RAF1 0.018 0.048 -10000 0 -10000 0 0
EP300 -0.007 0.018 -10000 0 -0.31 2 2
mol:GDP 0.021 0.051 -10000 0 -10000 0 0
mol:PI-3-4-5-P3 0 0 -10000 0 -10000 0 0
TSC2 0.018 0.048 -10000 0 -10000 0 0
YWHAQ -0.006 0 -10000 0 -10000 0 0
TBC1D4 -0.003 0.014 0.13 6 -10000 0 6
MAP3K5 -0.006 0.023 0.24 2 -0.31 2 4
MAPKAP1 -0.006 0 -10000 0 -10000 0 0
negative regulation of cell cycle -0.01 0.029 -10000 0 -10000 0 0
YWHAH -0.007 0.022 -10000 0 -0.31 3 3
AKT1S1 0.018 0.048 -10000 0 -10000 0 0
CASP9 0.018 0.048 -10000 0 -10000 0 0
YWHAB -0.005 0.01 0.24 1 -10000 0 1
p27Kip1/KPNA1 0.016 0.049 0.23 1 -10000 0 1
GBL -0.006 0 -10000 0 -10000 0 0
PDK1/Src/Hsp90 0.008 0.008 -10000 0 -0.18 1 1
YWHAE -0.006 0.013 -10000 0 -0.31 1 1
SRC -0.006 0 -10000 0 -10000 0 0
AKT2/p21CIP1 0.012 0.05 0.19 3 -10000 0 3
KIAA1303 -0.006 0 -10000 0 -10000 0 0
mTOR/RHEB/GTP/Raptor/GBL 0.016 0.029 -10000 0 -10000 0 0
CHUK 0.022 0.055 0.25 8 -10000 0 8
BAD/BCL-XL 0.014 0.047 -10000 0 -10000 0 0
mTORC2 0.013 0.014 0.15 6 -10000 0 6
AKT2 0 0.015 0.16 5 -10000 0 5
FOXO1-3a-4/14-3-3 family 0.014 0.042 -10000 0 -10000 0 0
PDPK1 -0.006 0 -10000 0 -10000 0 0
MDM2 0.018 0.049 -10000 0 -10000 0 0
MAPKKK cascade -0.017 0.047 -10000 0 -10000 0 0
MDM2/Cbp/p300 0.01 0.052 -10000 0 -10000 0 0
TSC1/TSC2 0.015 0.047 -10000 0 -10000 0 0
proteasomal ubiquitin-dependent protein catabolic process 0.01 0.049 -10000 0 -10000 0 0
glucose import -0.005 0.012 0.14 1 -10000 0 1
mTOR/RHEB/GDP/Raptor/GBL/PRAS40 0.019 0.038 -10000 0 -10000 0 0
response to stress 0 0 -10000 0 -10000 0 0
SLC2A4 -0.005 0.012 0.14 1 -10000 0 1
GSK3A 0.017 0.048 -10000 0 -10000 0 0
FOXO1 0.016 0.05 -10000 0 -10000 0 0
GSK3B 0.018 0.048 -10000 0 -10000 0 0
SFN 0.003 0.047 0.24 21 -10000 0 21
G1/S transition of mitotic cell cycle 0.015 0.046 -10000 0 -10000 0 0
p27Kip1/14-3-3 family 0.006 0.024 -10000 0 -10000 0 0
PRKACA -0.006 0 -10000 0 -10000 0 0
KPNA1 -0.005 0.015 0.24 2 -10000 0 2
HSP90AA1 -0.006 0.013 -10000 0 -0.31 1 1
YWHAG -0.006 0 -10000 0 -10000 0 0
RHEB 0.006 0.052 0.24 26 -10000 0 26
CREBBP -0.012 0.042 -10000 0 -0.31 11 11
p38 MAPK signaling pathway

Figure S121.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S121.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
TRAF6/ASK1 -0.003 0.012 0.14 2 -0.14 2 4
TRAF2/ASK1 0.006 0.014 0.15 2 -0.18 2 4
ATM 0.002 0.043 0.24 18 -10000 0 18
MAP2K3 0 0.036 0.19 1 -0.31 4 5
response to stress 0 0 -10000 0 -10000 0 0
MAP2K6 0.011 0.042 0.2 3 -10000 0 3
hyperosmotic response 0 0 -10000 0 -10000 0 0
response to oxidative stress 0 0 -10000 0 -10000 0 0
GADD45G -0.01 0.036 -10000 0 -0.31 8 8
TXN -0.009 0.044 -10000 0 -0.24 20 20
CALM1 -0.012 0.042 -10000 0 -0.31 11 11
GADD45A 0.015 0.069 0.24 48 -10000 0 48
GADD45B -0.004 0.021 0.24 4 -10000 0 4
MAP3K1 -0.008 0.025 -10000 0 -0.31 4 4
MAP3K6 -0.006 0 -10000 0 -10000 0 0
MAP3K7 -0.003 0.025 0.24 6 -10000 0 6
MAP3K4 -0.006 0 -10000 0 -10000 0 0
mol:Ca2+ 0 0 -10000 0 -10000 0 0
ASK1/ASK2 -0.007 0.016 0.17 2 -0.21 2 4
TAK1/TAB family 0.004 0.015 -10000 0 -10000 0 0
RAC1/OSM/MEKK3 0.008 0.007 -10000 0 -0.16 1 1
TRAF2 -0.006 0 -10000 0 -10000 0 0
RAC1/OSM/MEKK3/MKK3 -0.009 0.024 -10000 0 -0.25 4 4
TRAF6 0 0.015 0.16 5 -10000 0 5
RAC1 -0.006 0.013 -10000 0 -0.31 1 1
mol:LPS 0 0 -10000 0 -10000 0 0
CAMK2B -0.006 0 -10000 0 -10000 0 0
CCM2 -0.006 0 -10000 0 -10000 0 0
CaM/Ca2+/CAMKIIB 0.002 0.025 -10000 0 -0.18 11 11
MAPK11 -0.006 0 -10000 0 -10000 0 0
response to DNA damage stimulus 0 0 -10000 0 -10000 0 0
CaM/Ca2+/CAMKIIB/ASK1 0.005 0.026 0.15 2 -0.16 13 15
OSM/MEKK3 -0.007 0 -10000 0 -10000 0 0
TAOK1 0.003 0.03 0.16 19 -0.24 1 20
TAOK2 0.003 0.028 0.16 18 -10000 0 18
TAOK3 0.003 0.028 0.16 18 -10000 0 18
MAP3K7IP1 -0.006 0 -10000 0 -10000 0 0
MAPK14 -0.005 0.01 0.24 1 -10000 0 1
MAP3K7IP2 -0.004 0.018 0.24 3 -10000 0 3
MAP3K5 -0.006 0.023 0.24 2 -0.31 2 4
MAP3K10 -0.006 0 -10000 0 -10000 0 0
MAP3K3 -0.006 0 -10000 0 -10000 0 0
TRX/ASK1 -0.01 0.04 0.17 2 -0.2 22 24
GADD45/MTK1/MTK1 0.02 0.043 0.15 49 -0.15 7 56
Arf6 trafficking events

Figure S122.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S122.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
SLC2A4 -0.006 0 -10000 0 -10000 0 0
CLTC 0.006 0.032 0.18 1 -0.48 1 2
calcium ion-dependent exocytosis 0.003 0.02 -10000 0 -0.17 1 1
Dynamin 2/GTP 0 0.031 0.13 30 -0.16 1 31
EXOC4 -0.004 0.021 0.24 4 -10000 0 4
CD59 0.004 0.026 -10000 0 -0.43 1 1
CPE -0.008 0.052 0.17 22 -0.18 31 53
CTNNB1 -0.005 0.015 0.24 2 -10000 0 2
membrane fusion 0.003 0.02 -10000 0 -0.15 1 1
CTNND1 -0.002 0.029 0.12 30 -0.15 1 31
DNM2 -0.005 0.01 0.24 1 -10000 0 1
mol:PI-4-5-P2 0.002 0.021 -10000 0 -0.32 1 1
TSHR -0.001 0.029 0.17 16 -0.17 1 17
INS 0.003 0.007 -10000 0 -10000 0 0
BIN1 -0.007 0.018 -10000 0 -0.31 2 2
mol:Choline 0.003 0.02 -10000 0 -0.15 1 1
growth hormone secretagogue receptor activity 0 0 -10000 0 -10000 0 0
mol:GDP 0.003 0.038 0.17 29 -0.17 1 30
membrane depolarization 0 0 -10000 0 -10000 0 0
ARF6 -0.006 0.013 -10000 0 -0.31 1 1
mol:Ca2+ 0 0.031 0.13 30 -0.16 1 31
JUP 0 0.034 -10000 0 -0.17 13 13
ASAP2/amphiphysin II 0.005 0.012 -10000 0 -0.16 3 3
ARF6/GTP -0.004 0.009 -10000 0 -0.21 1 1
CDH1 0.001 0.033 -10000 0 -0.17 11 11
clathrin-independent pinocytosis -0.004 0.009 -10000 0 -0.21 1 1
MAPK8IP3 -0.006 0 -10000 0 -10000 0 0
positive regulation of endocytosis -0.004 0.009 -10000 0 -0.21 1 1
EXOC2 -0.001 0.034 0.24 11 -10000 0 11
substrate adhesion-dependent cell spreading 0.006 0.03 0.2 1 -10000 0 1
insulin receptor binding 0 0 -10000 0 -10000 0 0
SPAG9 -0.005 0.01 0.24 1 -10000 0 1
regulation of calcium-dependent cell-cell adhesion 0.007 0.024 0.4 1 -0.14 3 4
positive regulation of phagocytosis -0.006 0.007 -10000 0 -0.17 1 1
ARF6/GTP/JIP3 0.006 0.008 -10000 0 -0.18 1 1
ACAP1 0.003 0.017 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
CHRM2 0.004 0.026 -10000 0 -0.43 1 1
clathrin heavy chain/ACAP1 0.005 0.029 0.14 3 -0.4 1 4
JIP4/KLC1 0.009 0.011 0.15 2 -0.16 1 3
EXOC1 -0.002 0.031 0.24 9 -10000 0 9
exocyst 0.006 0.03 0.2 1 -10000 0 1
RALA/GTP -0.003 0.01 0.17 2 -10000 0 2
ARF6/GTP/ARF6/GTP/JIP4/Dynactin Complex 0.006 0.01 0.15 1 -0.18 1 2
receptor recycling -0.004 0.009 -10000 0 -0.21 1 1
CTNNA1 -0.003 0.031 0.12 30 -0.15 3 33
NME1 0.003 0.039 0.17 29 -0.17 1 30
clathrin coat assembly 0.006 0.032 0.16 2 -0.48 1 3
IL2RA 0.005 0.028 -10000 0 -0.43 1 1
VAMP3 -0.006 0.007 -10000 0 -0.17 1 1
GLUT4/clathrin heavy chain/ACAP1 -0.004 0.016 -10000 0 -0.38 1 1
EXOC6 0.003 0.046 0.24 20 -10000 0 20
PLD1 0.006 0.028 -10000 0 -10000 0 0
PLD2 -0.001 0.007 -10000 0 -10000 0 0
EXOC5 -0.005 0.015 0.24 2 -10000 0 2
PIP5K1C 0.002 0.021 -10000 0 -0.33 1 1
SDC1 0.004 0.028 0.13 1 -0.43 1 2
ARF6/GDP 0.002 0.033 0.14 29 -0.18 1 30
EXOC7 -0.006 0 -10000 0 -10000 0 0
E-cadherin/beta catenin -0.002 0.036 0.14 3 -0.42 1 4
mol:Phosphatidic acid 0.003 0.02 -10000 0 -0.15 1 1
endocytosis -0.005 0.012 0.16 3 -10000 0 3
SCAMP2 -0.006 0 -10000 0 -10000 0 0
ADRB2 0.004 0.031 0.17 1 -0.46 1 2
EXOC3 -0.005 0.01 0.24 1 -10000 0 1
ASAP2 0 0 -10000 0 -10000 0 0
Dynamin 2/GDP 0 0.034 0.14 30 -0.16 1 31
KLC1 -0.005 0.01 0.24 1 -10000 0 1
AVPR2 0.004 0.031 0.17 1 -0.46 1 2
RALA -0.005 0.015 0.24 2 -10000 0 2
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.006 0.035 0.14 1 -0.4 1 2
Class IB PI3K non-lipid kinase events

Figure S123.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S123.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
cAMP biosynthetic process 0.003 0.025 -10000 0 -0.24 6 6
PI3K Class IB/PDE3B -0.003 0.025 0.24 6 -10000 0 6
PDE3B -0.003 0.025 0.24 6 -10000 0 6
Sumoylation by RanBP2 regulates transcriptional repression

Figure S124.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S124.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
HDAC1 0.01 0.06 0.24 36 -10000 0 36
Ran/GTP/Exportin 1/HDAC4 -0.008 0.002 -10000 0 -10000 0 0
MDM2/SUMO1 0.005 0.012 0.15 2 -10000 0 2
HDAC4 -0.006 0 -10000 0 -10000 0 0
Ran/GTP/Exportin 1/HDAC1 -0.008 0.003 -10000 0 -10000 0 0
SUMO1 -0.006 0 -10000 0 -10000 0 0
NPC/RanGAP1/SUMO1 -0.001 0.006 -10000 0 -10000 0 0
mol:GTP 0 0 -10000 0 -10000 0 0
XPO1 0.007 0.035 0.12 46 -10000 0 46
EntrezGene:23636 0 0 -10000 0 -10000 0 0
RAN -0.006 0 -10000 0 -10000 0 0
EntrezGene:8021 0 0 -10000 0 -10000 0 0
RANBP2 -0.005 0.015 0.24 2 -10000 0 2
SUMO1/HDAC4 0.005 0 -10000 0 -10000 0 0
SUMO1/HDAC1 0.014 0.036 0.15 36 -10000 0 36
RANGAP1 -0.006 0 -10000 0 -10000 0 0
MDM2/SUMO1/SUMO1 0.012 0.019 -10000 0 -0.16 2 2
NPC/RanGAP1/SUMO1/RanBP2/Ubc9 -0.001 0.006 -10000 0 -10000 0 0
Ran/GTP -0.003 0.005 -10000 0 -10000 0 0
EntrezGene:23225 0 0 -10000 0 -10000 0 0
MDM2 -0.006 0.023 0.24 2 -0.31 2 4
UBE2I -0.006 0 -10000 0 -10000 0 0
Ran/GTP/Exportin 1 0.004 0.032 -10000 0 -10000 0 0
NPC 0.003 0.008 0.13 2 -10000 0 2
PIAS2 -0.004 0.021 0.24 4 -10000 0 4
PIAS1 -0.005 0.01 0.24 1 -10000 0 1
EntrezGene:9972 0 0 -10000 0 -10000 0 0
S1P4 pathway

Figure S125.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S125.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
mol:S1P 0 0 -10000 0 -10000 0 0
GNAO1 -0.004 0.028 0.24 6 -0.31 1 7
CDC42/GTP 0.009 0.037 -10000 0 -10000 0 0
PLCG1 0.012 0.042 0.19 3 -10000 0 3
mol:GTP 0 0 -10000 0 -10000 0 0
GNAI2 -0.006 0 -10000 0 -10000 0 0
GNAI3 0.036 0.093 0.24 96 -10000 0 96
G12/G13 -0.007 0.009 -10000 0 -0.21 1 1
cell migration 0.009 0.037 -10000 0 -10000 0 0
S1PR5 0 0 -10000 0 -10000 0 0
S1PR4 0 0 -10000 0 -10000 0 0
MAPK3 0.008 0.043 0.17 2 -10000 0 2
MAPK1 0.011 0.041 0.17 2 -10000 0 2
S1P/S1P5/Gi 0.014 0.043 0.18 2 -0.17 6 8
GNAI1 -0.005 0.041 0.24 8 -0.31 5 13
CDC42/GDP -0.003 0 -10000 0 -10000 0 0
S1P/S1P5/G12 0.003 0 -10000 0 -10000 0 0
RHOA -0.007 0.006 -10000 0 -0.15 1 1
S1P/S1P4/Gi 0.014 0.043 0.18 2 -0.17 6 8
mol:GDP 0 0 -10000 0 -10000 0 0
GNAZ -0.008 0.025 -10000 0 -0.31 4 4
S1P/S1P4/G12/G13 0.005 0.007 -10000 0 -0.16 1 1
GNA12 -0.006 0 -10000 0 -10000 0 0
GNA13 -0.006 0.013 -10000 0 -0.31 1 1
CDC42 -0.006 0 -10000 0 -10000 0 0
JNK signaling in the CD4+ TCR pathway

Figure S126.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S126.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
LAT/GRAP2/SLP76/HPK1 0.006 0.03 -10000 0 -0.16 17 17
MAP4K1 -0.005 0.015 0.24 2 -10000 0 2
MAP3K8 -0.006 0 -10000 0 -10000 0 0
PRKCB 0 0 -10000 0 -10000 0 0
DBNL -0.006 0 -10000 0 -10000 0 0
CRKL -0.006 0 -10000 0 -10000 0 0
MAP3K1 -0.011 0.032 -10000 0 -10000 0 0
JUN 0.001 0.027 -10000 0 -10000 0 0
MAP3K7 -0.009 0.033 -10000 0 -10000 0 0
GRAP2 -0.006 0 -10000 0 -10000 0 0
CRK -0.005 0.01 0.24 1 -10000 0 1
MAP2K4 -0.011 0.034 -10000 0 -10000 0 0
LAT -0.006 0 -10000 0 -10000 0 0
LCP2 -0.015 0.053 -10000 0 -0.31 18 18
MAPK8 0 0.017 -10000 0 -10000 0 0
LAT/GRAP2/SLP76/HPK1/HIP-55/CRK family -0.008 0.031 -10000 0 -0.18 17 17
LAT/GRAP2/SLP76/HPK1/HIP-55 0.008 0.029 -10000 0 -0.15 17 17
Alternative NF-kappaB pathway

Figure S127.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S127.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
IKK alpha homodimer -0.001 0.031 0.17 18 -10000 0 18
FBXW11 -0.006 0 -10000 0 -10000 0 0
proteasomal ubiquitin-dependent protein catabolic process 0 0 -10000 0 -10000 0 0
beta TrCP1/SCF ubiquitin ligase complex -0.006 0 -10000 0 -10000 0 0
CHUK 0.002 0.043 0.24 18 -10000 0 18
NF kappa B2 p100/RelB 0.016 0.025 -10000 0 -0.15 2 2
NFKB1 -0.01 0.033 -10000 0 -0.31 7 7
MAP3K14 -0.006 0 -10000 0 -10000 0 0
NF kappa B1 p50/RelB -0.01 0.026 -10000 0 -0.21 9 9
RELB -0.007 0.018 -10000 0 -0.31 2 2
NFKB2 -0.006 0 -10000 0 -10000 0 0
NF kappa B2 p52/RelB 0.005 0.011 -10000 0 -0.18 2 2
regulation of B cell activation 0.005 0.011 -10000 0 -0.17 2 2
Visual signal transduction: Rods

Figure S128.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S128.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
mol:K + -0.006 0 -10000 0 -10000 0 0
GNAT1/GTP -0.003 0 -10000 0 -10000 0 0
Metarhodopsin II/Arrestin 0.006 0 -10000 0 -10000 0 0
PDE6G/GNAT1/GTP 0.006 0.006 0.15 1 -10000 0 1
mol:GTP 0 0 -10000 0 -10000 0 0
absorption of light 0 0 -10000 0 -10000 0 0
GNAT1 -0.006 0 -10000 0 -10000 0 0
GRK1 0 0 -10000 0 -10000 0 0
CNG Channel -0.014 0.016 -10000 0 -0.14 9 9
mol:Na + -0.016 0.016 -10000 0 -0.14 9 9
mol:ADP 0 0 -10000 0 -10000 0 0
RGS9-1/Gbeta5/R9AP 0.007 0.019 -10000 0 -0.18 6 6
mol:GDP 0 0 -10000 0 -10000 0 0
cGMP/CNG Channel -0.016 0.018 0.12 2 -10000 0 2
CNGB1 -0.006 0 -10000 0 -10000 0 0
RDH5 0.002 0.043 0.24 18 -10000 0 18
SAG -0.006 0 -10000 0 -10000 0 0
mol:Ca2+ -0.017 0.017 -10000 0 -10000 0 0
Na + (4 Units) -0.017 0.015 -10000 0 -0.14 9 9
RGS9 -0.006 0 -10000 0 -10000 0 0
GNB1/GNGT1 -0.005 0.021 0.17 7 -0.21 1 8
GNAT1/GDP 0.008 0.016 -10000 0 -0.15 6 6
GUCY2D -0.006 0 -10000 0 -10000 0 0
GNGT1 -0.003 0.027 0.24 7 -10000 0 7
GUCY2F -0.006 0 -10000 0 -10000 0 0
GNB5 -0.009 0.031 -10000 0 -0.31 6 6
mol:GMP (4 units) -0.008 0.01 0.13 3 -10000 0 3
mol:11-cis-retinal 0.002 0.043 0.24 18 -10000 0 18
mol:cGMP -0.011 0.009 0.15 2 -10000 0 2
GNB1 -0.006 0.013 -10000 0 -0.31 1 1
Rhodopsin -0.001 0.031 0.17 18 -10000 0 18
SLC24A1 -0.006 0 -10000 0 -10000 0 0
CNGA1 -0.011 0.038 -10000 0 -0.31 9 9
Metarhodopsin II 0.003 0 -10000 0 -10000 0 0
mol:Ca ++ 0 0 -10000 0 -10000 0 0
GC1/GCAP Family 0.012 0.008 0.15 2 -10000 0 2
RGS9BP -0.006 0 -10000 0 -10000 0 0
Metarhodopsin II/Transducin -0.001 0.014 -10000 0 -0.18 1 1
GCAP Family/Ca ++ 0.009 0.008 0.15 2 -10000 0 2
PDE6A/B -0.006 0.01 0.17 2 -10000 0 2
mol:Pi 0.007 0.019 -10000 0 -0.18 6 6
mol:all-trans-retinal 0 0 -10000 0 -10000 0 0
Transducin 0.01 0.017 0.15 7 -0.16 1 8
PDE6B -0.005 0.01 0.24 1 -10000 0 1
PDE6A -0.005 0.01 0.24 1 -10000 0 1
PDE6G -0.005 0.01 0.24 1 -10000 0 1
RHO -0.006 0 -10000 0 -10000 0 0
PDE6 -0.013 0.017 -10000 0 -10000 0 0
GUCA1A -0.006 0 -10000 0 -10000 0 0
GC2/GCAP Family 0.012 0.008 0.15 2 -10000 0 2
GUCA1C -0.005 0.015 0.24 2 -10000 0 2
GUCA1B -0.006 0 -10000 0 -10000 0 0
Visual signal transduction: Cones

Figure S129.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S129.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Cone Metarhodopsin II/Cone Transducin 0.008 0 -9999 0 -10000 0 0
RGS9BP -0.006 0 -9999 0 -10000 0 0
mol:GTP 0 0 -9999 0 -10000 0 0
GRK1 0 0 -9999 0 -10000 0 0
mol:Na + 0.006 0 -9999 0 -10000 0 0
mol:ADP -0.003 0 -9999 0 -10000 0 0
GNAT2 -0.006 0 -9999 0 -10000 0 0
RGS9-1/Gbeta5/R9AP 0.007 0.019 -9999 0 -0.18 6 6
mol:GDP 0 0 -9999 0 -10000 0 0
PDE6H/GNAT2/GTP 0.006 0 -9999 0 -10000 0 0
GRK7 -0.006 0 -9999 0 -10000 0 0
CNGB3 -0.006 0 -9999 0 -10000 0 0
Cone Metarhodopsin II/X-Arrestin -0.003 0 -9999 0 -10000 0 0
mol:Ca2+ -0.007 0 -9999 0 -10000 0 0
Cone PDE6 0.011 0.017 -9999 0 -0.15 6 6
Cone Metarhodopsin II 0.003 0 -9999 0 -10000 0 0
Na + (4 Units) 0.008 0 -9999 0 -10000 0 0
GNAT2/GDP 0.008 0.016 -9999 0 -0.15 6 6
GNB5 -0.009 0.031 -9999 0 -0.31 6 6
mol:GMP (4 units) -0.007 0 -9999 0 -10000 0 0
Cone Transducin 0.008 0 -9999 0 -10000 0 0
SLC24A2 -0.006 0 -9999 0 -10000 0 0
GNB3/GNGT2 -0.007 0 -9999 0 -10000 0 0
GNB3 -0.006 0 -9999 0 -10000 0 0
GNAT2/GTP -0.003 0 -9999 0 -10000 0 0
CNGA3 -0.006 0 -9999 0 -10000 0 0
ARR3 -0.006 0 -9999 0 -10000 0 0
absorption of light 0 0 -9999 0 -10000 0 0
cGMP/Cone CNG Channel 0.006 0 -9999 0 -10000 0 0
mol:Pi 0.007 0.019 -9999 0 -0.18 6 6
Cone CNG Channel -0.011 0 -9999 0 -10000 0 0
mol:all-trans-retinal 0 0 -9999 0 -10000 0 0
mol:K + -0.006 0 -9999 0 -10000 0 0
RGS9 -0.006 0 -9999 0 -10000 0 0
PDE6C -0.006 0 -9999 0 -10000 0 0
GNGT2 -0.006 0 -9999 0 -10000 0 0
mol:cGMP (4 units) 0 0 -9999 0 -10000 0 0
PDE6H -0.006 0 -9999 0 -10000 0 0
Glypican 2 network

Figure S130.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S130.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
MDK -0.005 0.01 0.24 1 -9999 0 1
GPC2 -0.006 0 -10000 0 -9999 0 0
GPC2/Midkine -0.007 0.007 0.17 1 -9999 0 1
neuron projection morphogenesis -0.007 0.007 0.17 1 -9999 0 1
Rapid glucocorticoid signaling

Figure S131.  Get High-res Image This plot shows pathway concept perturbations across all samples against a permutation model. The concepts along the x-axis are sorted by lowest to highest mean activity for the real patient samples. Mean inferred activities are plotted along the y-axis as a colored band showing the average level and one standard deviation range. Real samples are shown in red and permuted samples in black.

Table S131.  Get Full Table This table displays mean, standard deviation, and perturbation statistics for Inferred Pathway Levels (IPLs). A mean perturbation of -9999 implies that the IPLs across all the real samples did not differ enough from the IPLs generated by a background model of permuted samples (> 1 Std.Dev from the permuted sample IPLs).

Entity Mean Std.Dev Mean.of.Up.Perturbations Number.of.Up.Perturbations Mean.of.Down.Perturbations Number.of.Down.Perturbations Number.of.Total.Perturbations
Gs family/GDP/Gbeta gamma 0.008 0.009 0.14 1 -0.15 1 2
MAPK9 -0.001 0.012 0.16 1 -0.24 1 2
adrenocorticotropin secretion -0.003 0.008 0.2 1 -10000 0 1
GNB1/GNG2 0.006 0.01 0.15 1 -0.18 1 2
GNB1 -0.006 0.013 -10000 0 -0.31 1 1
regulation of calcium ion transport via voltage-gated calcium channel activity 0 0 -10000 0 -10000 0 0
mol:GDP 0 0 -10000 0 -10000 0 0
MAPK14 -0.001 0.007 0.16 1 -10000 0 1
Gs family/GTP 0.003 0 -10000 0 -10000 0 0
EntrezGene:2778 0 0 -10000 0 -10000 0 0
vasopressin secretion 0 0 -10000 0 -10000 0 0
G-protein coupled receptor activity 0 0 -10000 0 -10000 0 0
ChemicalAbstracts:86-01-1 0 0 -10000 0 -10000 0 0
glutamate secretion 0.001 0 -10000 0 -10000 0 0
GNAL -0.006 0 -10000 0 -10000 0 0
GNG2 -0.005 0.01 0.24 1 -10000 0 1
CRH -0.005 0.01 0.24 1 -10000 0 1
mol:cortisol 0 0 -10000 0 -10000 0 0
MAPK8 0.001 0.016 0.16 6 -10000 0 6
MAPK11 -0.001 0 -10000 0 -10000 0 0
Inferred Pathway Levels Matrix

Table 3.  Get Full Table First 10 out of 7202 rows and 4 out of 569 columns in the PARADIGM inferred pathway levels matrix.

pid_entity TCGA.61.2614 TCGA.61.2613 TCGA.61.2612 TCGA.61.2113
109_MAP3K5 -0.0032 -0.0032 -0.0032 -0.0032
47_PPARGC1A -0.0058 -0.0058 -0.0058 -0.0058
105_BMP4 -0.0058 -0.0058 -0.0058 -0.0058
105_BMP6 -0.0058 -0.0058 -0.0058 -0.0058
105_BMP7 0.24 -0.0058 -0.0058 -0.0058
105_BMP2 -0.0058 -0.0058 -0.0058 -0.0058
131_RELN/VLDLR 0.011 0.011 0.011 0.011
30_TGFB1/TGF beta receptor Type II -0.0058 -0.0058 -0.0058 -0.0058
84_STAT5B -0.041 -0.041 -0.041 0.065
84_STAT5A -0.041 -0.041 -0.041 0.065
Methods & Data
Input

  • Expression Data Normalization = Normal controls were used to median center the expression data used in this analysis.

  • mRNA Expression File Used = /xchip/cga/gdac-prod/tcga-gdac/jobResults/GDAC_MergeDataFilesPipeline/OV-TP/22229450/GDAC_MergeDataFiles_12185952/OV-TP.exon__huex_1_0_st_v2__lbl_gov__Level_3__quantile_normalization_gene__data.data.txt

  • Copy Number File Used = Copy number data was not used in this analysis.

Data Sets and Pathway Interactions

Both copy number and expression data are incorporated into PARADIGM's inference. Whenever normal tissue controls are available for analysis in the expression data, each patient's gene-value is normalized by subtracting the gene's median level observed in the normal control. Copy number data is also normalized to reflect the difference in copy number between a gene's levels detected in tumor versus control (e.g. blood normal). The collection of pathways used by PARADIGM includes those from NCI-PID on September 15, 2009 containing 131 pathways, 11,563 interactions, and 7,204 entities. All gene identifiers were translated into HUGO standard identifiers wherever possible. We refer to molecular entities as "concepts," which include gene products such as proteins and miRNAs, small molecules, protein complexes, and abstract concepts. Each concept is represented as "node" in PARADIGM's graphical model. The abstract concepts correspond to general cellular processes (such as "apoptosis" or "DNA damage response") and families of genes that share functional activity such as the RAS family of signal transducers. Various types of concept-concept interactions are included in the pathways including protein-protein interactions, transcriptional regulatory interactions, and protein modifications such as phosphorylation and ubiquitinylation interactions.

Pathway Inference Method

The PARADIGM algorithm (described in PMID: 20529912) assigns an integrated pathway level (IPL) reflecting the activity of a concept determined through a belief propagation strategy. The belief propagation is given the copy number and gene expression measurements of all of the genes and iteratively updates hidden states reflecting the activities of all of the genes in a pathway so as to maximize the likelihood of the observed data given the interactions in the pathway. In the end, the inferred level of a concept reflects both the data observed for the concept and the neighborhood of activity surrounding the concept.

Determining significantly altered levels

The significance of the IPL obtained for each concept in each patient sample is assessed using a permutation analysis. Importantly, the permutation analysis preserves data tuples so as to preserve any implicit correlations between the different data modalities. For example, genes that are deleted have concomitantly lower expression levels. Preserving the copy number and expression pairs therefore retains this data property. The simulation therefore makes "null samples" by permuting data tuples across all of the genes in the genome so that each gene in a null sample is associated with a random tuple of another gene with equal probability. This approach has the added benefit of preserving the pathway structure so that every observed IPL can be compared to a distribution of random IPLs derived from exactly the same interaction context. PARADIGM inferences are then obtained for 1000 "null" patients and serve as a background distribution to contrast the observed IPLs against. Pathway concepts are excluded from further analysis if they did not obtain a minimum IPL of 0.5 in any patient sample both observed or simulated.

An IPL I(i,j) for concept i in sample j, is considered to be deviated if its absolute level is two standard deviations from the average level observed for concept i in the 1000 null samples. The degree to which a concept has significantly altered levels across a patient cohort is summarized in the proportion of deviated samples (PDS) score. For example, a protein with a PDS of 0.10 reflects that the protein's level of activity was inferred to be significantly higher or lower in tumors compared to normal in 10% of the patient samples. An average PDS for a pathway is also reported by computing the mean PDS over all concepts in the pathway.

Download Results

In addition to the links below, the full results of the analysis summarized in this report can also be downloaded programmatically using firehose_get, or interactively from either the Broad GDAC website or TCGA Data Coordination Center Portal.

References
[2] Charles J. Vaske, Stephen C. Benz, J. Zachary Sanborn, Dent Earl, Christopher Szeto, Jingchun Zhu, David Haussler, and Joshua M. Stuart, Inference of patient-specific pathway activities from multi-dimensional cancer genomics data using PARADIGM, Bioinformatics 12(26):237-245 (2010)
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