Conservation (pFN) = Probability that mutations within

this gene occur disproportionately at evolutionarily

conserved sites. Sites highly conserved across

vertebrates are assumed to have greater functional

q = q-value, False Discovery Rate (Benjamini-Hochberg procedure)

This figure depicts the distribution of mutations and mutation types across the TP53 significant gene.

This figure depicts the distribution of mutations and mutation types across the EGFR significant gene.

This figure depicts the distribution of mutations and mutation types across the KRAS significant gene.

This figure depicts the distribution of mutations and mutation types across the STK11 significant gene.

This figure depicts the distribution of mutations and mutation types across the KEAP1 significant gene.

This figure depicts the distribution of mutations and mutation types across the RB1 significant gene.

This figure depicts the distribution of mutations and mutation types across the IL21R significant gene.

This figure depicts the distribution of mutations and mutation types across the C10orf62 significant gene.

This figure depicts the distribution of mutations and mutation types across the EGFL6 significant gene.

This figure depicts the distribution of mutations and mutation types across the CLIP2 significant gene.

This figure depicts the distribution of mutations and mutation types across the BIRC6 significant gene.

This figure depicts the distribution of mutations and mutation types across the TLR7 significant gene.

This figure depicts the distribution of mutations and mutation types across the C16orf82 significant gene.

A Ranked List of Significantly Mutated Genes. Number of significant genes found: 14. Number of genes displayed: 35. Click on a gene name to display its stick figure depicting the distribution of mutations and mutation types across the chosen gene (this feature may not be available for all significant genes).

MutSig and its evolving algorithms have existed since
                    the youth of clinical sequencing, with early versions
                    used in multiple publications.