(primary solid tumor cohort)
The correlation coefficients in 10, 20, 30, 40, 50, 60, 70, 80, 90 percentiles are 953.4, 1848.8, 2387.2, 2921, 3435, 3984, 4584.8, 5254, 6118.6, respectively.
Number of genes and samples used for the calculation are shown in Table 1. Figure 1 shows the distribution of calculated correlation coefficients and quantile-quantile plot of the calculated correlation coefficients against a normal distribution. Table 2 shows the top 20 features ordered by the value of correlation coefficients.
Table 1. Counts of mRNAseq and number of samples in copy number and expression data sets and common to both
| Category | Copy number | Expression | Common |
|---|---|---|---|
| Sample | 563 | 154 | 148 |
| Genes | 23778 | 18190 | 18095 |
Figure 1. Summary figures. Left: histogram showing the distribution of the calculated correlations across samples for all Genes. Right: QQ plot of the calculated correlations across samples. The QQ plot is used to plot the quantiles of the calculated correlation coefficients against that derived from a normal distribution. Points deviating from the blue line indicate deviation from normality.
Table 2. Get Full Table Top 20 features (defined by the feature column) ranked by correlation coefficients
| Locus ID | Gene Symbol | Cytoband | cor | p-value | q-value |
|---|---|---|---|---|---|
| 4193 | MDM2 | 12q15 | 0.9336 | 0 | 0 |
| 92979 | MARCH9 | 12q14.1 | 0.9098 | 0 | 0 |
| 23480 | SEC61G | 7p11.2 | 0.9001 | 0 | 0 |
| 1019 | CDK4 | 12q14.1 | 0.8971 | 0 | 0 |
| 84919 | PPP1R15B | 1q32.1 | 0.8968 | 0 | 0 |
| 10540 | DCTN2 | 12q13.3 | 0.8966 | 0 | 0 |
| 10956 | OS9 | 12q13.3 | 0.8952 | 0 | 0 |
| 10102 | TSFM | 12q14.1 | 0.8947 | 0 | 0 |
| 79837 | PIP4K2C | 12q13.3 | 0.8855 | 0 | 0 |
| 55915 | LANCL2 | 7p11.2 | 0.8788 | 0 | 0 |
| 51373 | MRPS17 | 7p11.2 | 0.8785 | 0 | 0 |
| 55234 | SMU1 | 9p21.1 | 0.8738 | 0 | 0 |
| 6302 | TSPAN31 | 12q14.1 | 0.8717 | 0 | 0 |
| 4234 | METTL1 | 12q14.1 | 0.8714 | 0 | 0 |
| 115557 | ARHGEF25 | 12q13.3 | 0.8708 | 0 | 0 |
| 10106 | CTDSP2 | 12q14.1 | 0.8697 | 0 | 0 |
| 25895 | METTL21B | 12q14.1 | 0.8694 | 0 | 0 |
| 908 | CCT6A | 7p11.2 | 0.8641 | 0 | 0 |
| 196403 | DTX3 | 12q13.3 | 0.8635 | 0 | 0 |
| 55763 | EXOC1 | 4q12 | 0.8604 | 0 | 0 |