E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.048 0.179 -9999.0 0.0 -0.453 24.0 24.0 KLHL20 -0.03 0.059 -9999.0 0.0 -0.241 3.0 3.0 CYFIP2 0.009 0.047 -9999.0 0.0 -0.573 1.0 1.0 Rac1/GDP -0.007 0.123 -9999.0 0.0 -0.489 1.0 1.0 ENAH -0.048 0.179 -9999.0 0.0 -0.453 24.0 24.0 AP1M1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.007 0.057 -9999.0 0.0 -0.487 2.0 2.0 RAP1A 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.04 0.076 -9999.0 0.0 -0.385 1.0 1.0 ABI1/Sra1/Nap1 -0.021 0.041 -9999.0 0.0 -0.175 3.0 3.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.047 0.148 -9999.0 0.0 -0.326 27.0 27.0 RAPGEF1 -0.031 0.163 -9999.0 0.0 -0.394 24.0 24.0 CTNND1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.058 0.183 -9999.0 0.0 -0.472 24.0 24.0 CRK -0.04 0.17 -9999.0 0.0 -0.42 24.0 24.0 E-cadherin/gamma catenin/alpha catenin -0.053 0.156 -9999.0 0.0 -0.343 33.0 33.0 alphaE/beta7 Integrin 0.004 0.077 -9999.0 0.0 -0.377 6.0 6.0 IQGAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.022 0.032 -9999.0 0.0 -0.253 2.0 2.0 DLG1 -0.048 0.179 -9999.0 0.0 -0.453 24.0 24.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.031 0.056 -9999.0 0.0 -0.262 1.0 1.0 MLLT4 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.024 0.022 -9999.0 0.0 -0.253 1.0 1.0 PI3K -0.039 0.07 -9999.0 0.0 -0.346 1.0 1.0 ARF6 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.073 0.18 -9999.0 0.0 -0.411 33.0 33.0 TIAM1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ -0.035 0.125 -9999.0 0.0 -0.289 24.0 24.0 AKT1 -0.023 0.041 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.002 0.077 -9999.0 0.0 -0.545 3.0 3.0 CDH1 -0.108 0.232 -9999.0 0.0 -0.55 33.0 33.0 RhoA/GDP -0.007 0.123 -9999.0 0.0 -0.489 1.0 1.0 actin cytoskeleton organization 0.009 0.062 -9999.0 0.0 -0.185 2.0 2.0 CDC42/GDP -0.007 0.123 -9999.0 0.0 -0.489 1.0 1.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.031 0.111 -9999.0 0.0 -0.27 24.0 24.0 ITGB7 -0.002 0.09 -9999.0 0.0 -0.552 4.0 4.0 RAC1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin -0.036 0.133 -9999.0 0.0 -0.307 24.0 24.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.042 0.125 -9999.0 0.0 -0.28 33.0 33.0 mol:GDP -0.018 0.14 -9999.0 0.0 -0.471 2.0 2.0 CDC42/GTP/IQGAP1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.007 0.057 -9999.0 0.0 -0.487 2.0 2.0 p120 catenin/RhoA/GDP -0.049 0.103 -9999.0 0.0 -0.495 1.0 1.0 RAC1/GTP/IQGAP1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.017 0.035 -9999.0 0.0 -0.413 1.0 1.0 RHOA 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.007 0.053 -9999.0 0.0 -0.183 5.0 5.0 NME1 0.01 0.04 -9999.0 0.0 -0.487 1.0 1.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.048 0.179 -9999.0 0.0 -0.453 24.0 24.0 regulation of cell-cell adhesion -0.035 0.067 -9999.0 0.0 -0.332 1.0 1.0 WASF2 -0.01 0.021 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP -0.046 0.087 -9999.0 0.0 -0.447 1.0 1.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.041 0.148 -9999.0 0.0 -0.318 27.0 27.0 CCND1 0.008 0.063 -9999.0 0.0 -0.226 5.0 5.0 VAV2 -0.047 0.199 -9999.0 0.0 -0.459 26.0 26.0 RAP1/GDP -0.007 0.114 -9999.0 0.0 -0.486 1.0 1.0 adherens junction assembly -0.046 0.174 -9999.0 0.0 -0.438 24.0 24.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.009 0.047 -9999.0 0.0 -0.573 1.0 1.0 regulation of heterotypic cell-cell adhesion -0.032 0.142 -9999.0 0.0 -0.501 4.0 4.0 E-cadherin/beta catenin -0.072 0.14 -9999.0 0.0 -0.325 34.0 34.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.051 0.179 -9999.0 0.0 -0.452 24.0 24.0 PIK3CA 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.048 0.094 -9999.0 0.0 -0.381 4.0 4.0 E-cadherin/beta catenin/alpha catenin -0.05 0.146 -9999.0 0.0 -0.327 33.0 33.0 ITGAE 0.007 0.057 -9999.0 0.0 -0.487 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.059 0.187 -9999.0 0.0 -0.482 24.0 24.0