rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(3), CCNA2(1), CCND1(4), CCNE1(2), CCNE2(2), CDK2(1), CDK4(1), CDKN1B(4), CDKN2A(6), E2F1(1), E2F2(1), E2F4(1), PRB1(2)	10611291	29	25	28	0	5	1	6	7	10	0	0.000290	0.00744	1.000
2	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(5), CYP2C9(3)	2408511	8	8	8	0	4	2	0	1	1	0	0.0995	0.0113	1.000
3	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	14	ARF1(1), CCND1(4), CDK2(1), CDK4(1), CDKN1A(2), CDKN1B(4), CDKN2A(6), CFL1(1), E2F1(1), E2F2(1), MDM2(5), PRB1(2)	8984687	29	24	28	3	6	2	5	5	11	0	0.0194	0.0325	1.000
4	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(7), IFNG(2), IL12B(4), IL18(3)	3556416	16	12	16	3	4	2	2	6	2	0	0.232	0.101	1.000
5	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(3)	858097	3	3	3	1	2	1	0	0	0	0	0.562	0.104	1.000
6	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3D(1), CD3E(2), CD3G(1)	1356956	4	4	4	1	0	1	1	1	1	0	0.574	0.116	1.000
7	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD28(2), CD4(2), HLA-DRA(4), HLA-DRB1(1)	2835540	9	7	8	1	4	1	0	3	1	0	0.158	0.174	1.000
8	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(2), GSTZ1(3), HGD(5)	2655605	10	6	10	2	4	0	1	2	3	0	0.308	0.185	1.000
9	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(1), ACPP(4), ACPT(2), ENPP1(5), ENPP3(2), FLAD1(2), TYR(5)	11551817	21	18	21	1	8	2	3	6	2	0	0.0136	0.200	1.000
10	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCL11(2), CCL5(1), CCR3(2), CSF2(2), HLA-DRA(4), HLA-DRB1(1), IL3(2), IL5(1)	3625072	15	11	15	3	4	3	1	4	3	0	0.226	0.222	1.000
11	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	8	CCNA1(3), CCNE1(2), CDC34(2), CDK2(1), CUL1(4), E2F1(1), SKP2(3), TFDP1(1)	8110246	17	15	17	2	2	3	3	6	3	0	0.137	0.305	1.000
12	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(1), FDPS(3), GGPS1(1), IDI1(2), IDI2(1), SQLE(1)	5085440	9	8	9	0	1	0	5	1	2	0	0.0920	0.327	1.000
13	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	11	CCNE1(2), CDK2(1), CDKN1B(4), CUL1(4), E2F1(1), RBX1(1), SKP2(3), TFDP1(1), UBE2M(2)	8126334	19	17	19	3	1	4	4	5	5	0	0.153	0.327	1.000
14	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(1), FDPS(3), IDI1(2), SQLE(1)	3799471	7	6	7	0	1	0	4	0	2	0	0.163	0.354	1.000
15	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(3), IL13RA2(1), IL4R(10), JAK1(3), JAK2(5), TYK2(10)	12504243	32	25	32	4	11	1	3	10	7	0	0.0251	0.368	1.000
16	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(3), IL13RA2(1), IL4R(10), JAK1(3), JAK2(5), TYK2(10)	12504243	32	25	32	4	11	1	3	10	7	0	0.0251	0.368	1.000
17	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(2), PGLYRP2(3)	2166169	5	5	5	1	3	1	0	1	0	0	0.461	0.369	1.000
18	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(5), SUCLA2(1)	2518178	6	5	6	0	2	2	0	2	0	0	0.133	0.383	1.000
19	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(6), GOT1(2), GOT2(1), TAT(3), TYR(5)	5603870	17	13	16	3	9	1	3	4	0	0	0.178	0.389	1.000
20	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	7	CCNE1(2), CDC34(2), CDK2(1), CUL1(4), E2F1(1), FBXW7(5), TFDP1(1)	7780159	16	14	16	2	4	3	1	5	3	0	0.116	0.389	1.000
21	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	FABP6(2), LDLR(3), NR0B2(1), NR1H3(5), NR1H4(3), RXRA(4)	6495290	18	17	16	4	7	4	2	4	1	0	0.138	0.430	1.000
22	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALT(1), TGDS(2), UGDH(1), UXS1(4)	4597633	8	7	8	0	1	1	3	1	2	0	0.0832	0.439	1.000
23	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCL11(2), CCR3(2), CD4(2), HLA-DRA(4), HLA-DRB1(1), IL1B(3), IL5(1), IL5RA(3), IL6(2)	6370533	20	15	20	4	6	4	0	8	2	0	0.137	0.450	1.000
24	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(5), TPI1(1)	1963600	6	3	6	0	0	3	1	2	0	0	0.133	0.494	1.000
25	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(2), GOT2(1), TAT(3)	3131378	6	5	5	1	3	1	1	1	0	0	0.366	0.518	1.000
26	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RANBP1(1), RANBP2(13), RANGAP1(2)	10036099	16	14	16	2	3	2	3	5	3	0	0.0910	0.562	1.000
27	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	BCL2(2), CASP8(2), CFL1(1), CFLAR(1)	4613873	6	6	6	0	0	1	1	1	3	0	0.228	0.582	1.000
28	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(1), ACP6(2), ACPP(4), ACPT(2), ENPP1(5), ENPP3(2), FLAD1(2), LHPP(1), MTMR1(6), MTMR2(3), MTMR6(1), TYR(5)	17906495	34	28	34	4	11	5	6	8	4	0	0.0191	0.613	1.000
29	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ2(1), COQ3(2), COQ5(3), COQ6(2), NDUFA12(1), NDUFB11(1)	4803033	10	8	10	2	2	4	0	2	2	0	0.358	0.642	1.000
30	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(9), PDXK(1), PSAT1(4)	5777653	14	11	12	4	7	5	0	2	0	0	0.257	0.652	1.000
31	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(2), ALPP(7), ALPPL2(6), DHFR(1), FPGS(2), GGH(1), SPR(1)	7789811	20	18	18	5	10	3	4	1	2	0	0.152	0.652	1.000
32	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALT(1), TGDS(2), UGDH(1), UGP2(1), UXS1(4)	5849494	9	7	9	0	1	1	3	2	2	0	0.0676	0.653	1.000
33	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(2), BCKDK(3), CBS(5), CTH(2), MUT(2)	5851661	14	8	14	1	3	5	1	4	1	0	0.0414	0.661	1.000
34	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B4GALT2(1), FUT8(7), ST3GAL1(3), ST3GAL2(1), ST3GAL3(2), ST3GAL4(3)	9380176	17	16	17	3	6	2	3	3	3	0	0.161	0.678	1.000
35	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	11	AKT1(2), CAT(3), GH1(2), GHR(4), IGF1(3), IGF1R(10), SHC1(1), SOD2(1)	11367144	26	20	26	4	4	4	5	8	5	0	0.0411	0.683	1.000
36	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(1), CD3D(1), CD3E(2), CD3G(1), CD4(2), CD58(2), CD8A(1), IL3(2), IL6(2), KITLG(3)	7375172	17	13	17	3	3	2	2	8	2	0	0.188	0.688	1.000
37	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(1), CDO1(1), GAD1(3), GAD2(1), GGT1(3)	6862325	9	8	9	0	2	3	2	2	0	0	0.0365	0.700	1.000
38	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(2), LPL(2), NR3C1(3), PPARG(3), RETN(1), RXRA(4), TNF(1)	6919326	16	15	16	5	4	3	1	5	3	0	0.375	0.722	1.000
39	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(5), ALDOA(1), ALDOB(2), TPI1(1)	4659508	9	5	9	1	0	4	1	3	1	0	0.204	0.769	1.000
40	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	5	AKT1(2), PLCB1(4), PLCG1(12), PRKCA(6), VAV1(9)	10790092	33	28	31	9	8	4	4	11	5	1	0.321	0.774	1.000
41	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(2), GLS(4), GLUD1(5), OAT(1), PRODH(1)	6585024	13	9	13	3	3	1	0	5	4	0	0.339	0.789	1.000
42	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ASL(2), CPS1(8), GLS(4), GLUD1(5), GOT1(2)	9285437	21	13	21	3	4	1	2	7	7	0	0.184	0.807	1.000
43	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(3), GNB1(1), HTR2C(4), PLCB1(4), TUB(4)	8524566	16	13	16	4	5	3	0	6	2	0	0.352	0.812	1.000
44	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	CCL2(1), IL6(2), LDLR(3), LPL(2)	6351486	8	8	8	2	0	1	0	6	1	0	0.620	0.817	1.000
45	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3D(1), CD3E(2), CD3G(1), CD4(2), FYN(2), HLA-DRA(4), HLA-DRB1(1), LCK(1), PTPRC(9), ZAP70(8)	10786915	31	24	31	8	11	5	3	10	2	0	0.234	0.819	1.000
46	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(2), ALAS1(2), ALAS2(1), FECH(2), HMBS(1), PPOX(2), UROD(1), UROS(1)	9039631	12	9	12	1	2	3	2	3	2	0	0.0953	0.821	1.000
47	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	20	CCNA1(3), CCNB1(2), CCND1(4), CCND2(2), CCND3(1), CCNE1(2), CCNH(2), CDC25A(1), CDK2(1), CDK4(1), CDK6(1), CDK7(1), CDKN1A(2), CDKN1B(4), CDKN2A(6), CDKN2B(2), E2F1(1), RBL1(6), TFDP1(1)	16556563	43	31	42	6	7	6	7	13	10	0	0.0186	0.823	1.000
48	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(1), CDC25B(1), CDK7(1), CDKN1A(2), CHEK1(6), NEK1(4), WEE1(2)	8281240	17	15	17	4	5	4	2	4	2	0	0.488	0.828	1.000
49	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	14	APAF1(3), ATM(12), BAX(1), BCL2(2), CCND1(4), CCNE1(2), CDK2(1), CDK4(1), CDKN1A(2), E2F1(1), MDM2(5), TIMP3(2)	18555609	36	26	36	6	6	4	7	11	8	0	0.121	0.829	1.000
50	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(9), CD38(1), ENPP1(5), ENPP3(2), NADSYN1(5), NMNAT1(1), NNMT(1), NNT(6), NT5C(3), NT5E(3), NT5M(1)	17338009	37	28	35	6	8	11	6	9	3	0	0.0144	0.835	1.000
51	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CCR5(1), CD28(2), CD3D(1), CD3E(2), CD3G(1), CD4(2)	3831693	9	8	8	3	4	1	1	2	1	0	0.490	0.839	1.000
52	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	5	NFYA(1), NFYB(1), SP1(1), SP3(5)	5832797	8	7	8	2	1	1	2	2	2	0	0.574	0.854	1.000
53	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(3), CHRNA1(4)	3877000	7	7	7	3	2	2	1	1	1	0	0.585	0.859	1.000
54	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	10	CBL(2), CSF1R(5), EGF(10), MET(13), PRKCA(6), SH3GLB1(3), SH3KBP1(5), SRC(2)	17291858	46	27	46	11	15	3	5	15	7	1	0.135	0.860	1.000
55	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(4), GAD1(3), HDC(5), TH(3), TPH1(6)	7199507	21	16	20	6	11	4	0	5	1	0	0.169	0.860	1.000
56	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(3), JAK2(5), JAK3(5), MAPK1(4), MAPK3(2), STAT3(3), TYK2(10)	14051485	32	22	32	4	12	2	3	8	6	1	0.0325	0.864	1.000
57	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	ATP6V0C(1), GGT1(3), SHMT1(2)	4989898	6	5	6	1	2	2	2	0	0	0	0.240	0.866	1.000
58	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(5), PARK2(2), SNCA(1), SNCAIP(1), UBE2G2(1), UBE2L6(1)	7666562	11	11	11	3	7	1	0	2	1	0	0.294	0.872	1.000
59	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	16	AKT1(2), EIF2S2(2), EIF2S3(3), EIF4E(2), GSK3B(1), IGF1(3), IGF1R(10), INPPL1(8), PPP2CA(4), RPS6KB1(2)	17999931	37	26	37	5	6	3	7	12	9	0	0.0280	0.873	1.000
60	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(4), ANKRD1(1), CYR61(1), DUSP14(1), EIF4E(2), HBEGF(1), IFNG(2), IFRD1(4), IL18(3), IL1A(1), IL1R1(4), NR4A3(1), WDR1(4)	12870024	29	24	29	8	5	4	3	7	10	0	0.456	0.878	1.000
61	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	11	ACTR2(2), ACTR3(1), ARPC1A(1), ARPC1B(2), ARPC2(1), ARPC3(1), ARPC4(1), PAK1(3), RAC1(1), WASL(2)	8781151	15	9	14	3	0	2	0	7	6	0	0.543	0.885	1.000
62	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(1), SRP54(2), SRP68(2), SRP72(3), SRPR(7)	8985031	15	10	15	2	5	1	3	3	3	0	0.204	0.887	1.000
63	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(2), ACOX3(3), FADS2(2), PLA2G12B(1), PLA2G2D(1), PLA2G2F(1), PLA2G3(5), PLA2G4A(7), PLA2G5(1), PLA2G6(3)	12072044	26	17	26	5	6	4	4	9	3	0	0.135	0.889	1.000
64	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(7), LPO(5), MPO(4), PRDX1(1), TPO(10), TYR(5)	11523661	32	22	32	7	15	7	2	6	1	1	0.0438	0.904	1.000
65	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAD(2), ALAS1(2), ALAS2(1), CPO(3), FECH(2), GATA1(1), HBA2(1), HBB(1), HMBS(1), UROD(1), UROS(1)	9408152	16	12	16	3	4	3	2	5	2	0	0.164	0.906	1.000
66	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(2), HLCS(3)	3679734	5	3	5	2	1	1	0	2	1	0	0.649	0.909	1.000
67	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(12), CDC25A(1), CDC25B(1), CHEK1(6), MYT1(7), WEE1(2), YWHAH(2)	16422430	31	22	31	6	4	2	5	7	13	0	0.376	0.910	1.000
68	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(9), AGT(3), AGTR1(1), AGTR2(4), KNG1(4), NOS3(10), REN(7)	11856840	38	33	34	10	19	4	2	6	7	0	0.177	0.913	1.000
69	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(2), ENO1(2), GPI(2), HK1(4), PFKL(6), PGK1(3), PKLR(3), TPI1(1)	11052122	23	16	23	3	10	6	0	3	4	0	0.00892	0.914	1.000
70	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	7	ACO1(6), ACO2(4), FH(1), SUCLA2(1)	8651550	12	8	12	0	3	3	2	3	1	0	0.0186	0.914	1.000
71	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(2), IFNGR1(1), IFNGR2(4), JAK1(3), JAK2(5), STAT1(4)	9754486	19	14	19	4	1	0	4	8	5	1	0.339	0.920	1.000
72	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	APEX1(2), CREBBP(13), DFFA(2), GZMA(1), GZMB(3), HMGB2(1), PRF1(3), SET(1)	12619069	26	18	26	4	9	2	4	5	6	0	0.0687	0.921	1.000
73	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(2), ALDH1A2(2), RDH5(1)	4642321	5	5	5	2	2	3	0	0	0	0	0.530	0.922	1.000
74	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CCL3(1), CSF2(2), EPO(2), FLT3(8), IGF1(3), IL1A(1), IL3(2), IL6(2), IL9(1), KITLG(3), TGFB2(2), TGFB3(1)	9832303	28	21	28	9	4	4	5	10	5	0	0.433	0.924	1.000
75	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	9	ACLY(4), ACO1(6), ACO2(4), ACSS1(1), ACSS2(4), FH(1), SUCLA2(1)	13885531	21	13	21	1	6	5	2	4	4	0	0.00375	0.924	1.000
76	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(1), COASY(2), DPYD(6), DPYS(5), ENPP1(5), ENPP3(2), PANK2(1), PANK4(4)	16592909	26	21	25	5	5	5	0	11	5	0	0.269	0.929	1.000
77	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	13	AKT1(2), BCAR1(3), CDKN1B(4), ILK(1), ITGB1(3), MAPK1(4), MAPK3(2), PTK2(2), SHC1(1), SOS1(7)	17574501	29	21	29	3	6	2	6	6	8	1	0.0259	0.929	1.000
78	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(1), MTMR1(6), MTMR2(3), MTMR6(1), NFS1(3), THTPA(2)	7636551	16	9	16	4	3	3	3	5	2	0	0.470	0.931	1.000
79	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(4), CYP2E1(2), NR1I3(1), PTGS1(3), PTGS2(3)	6356355	13	12	13	4	5	2	0	3	3	0	0.510	0.933	1.000
80	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	11	ASAH1(2), BFAR(1), CREB1(2), MAPK1(4), RAF1(2), SNX13(1), SRC(2), TERF2IP(1)	11590827	15	12	15	2	1	1	5	3	5	0	0.104	0.935	1.000
81	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	5	SP1(1), SP3(5), WT1(3)	6752488	9	7	9	2	2	2	1	2	2	0	0.396	0.936	1.000
82	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	7	GABRA2(3), GABRA3(4), GABRA4(10), GABRA5(4), PRKCE(1)	7176879	22	21	22	8	4	5	5	6	2	0	0.511	0.946	1.000
83	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(7), LPO(5), MPO(4), TPO(10)	9989518	26	19	26	7	14	7	1	3	1	0	0.109	0.947	1.000
84	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(3), DCN(3), FMOD(2), KERA(4), LUM(7)	4318422	19	17	18	7	4	2	3	8	2	0	0.584	0.950	1.000
85	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(5), CKM(3), EIF4E(2), FBL(2), LDHA(1), LDHB(2), LDHC(1), NCL(3)	10639139	19	13	19	5	5	4	2	4	4	0	0.335	0.953	1.000
86	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	FUT1(1), FUT2(2), FUT3(2), FUT5(6), FUT6(3), ST3GAL3(2)	6075881	16	12	16	5	9	1	0	4	2	0	0.417	0.954	1.000
87	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CTH(2), GOT1(2), GOT2(1), LDHA(1), LDHB(2), LDHC(1)	8149545	9	6	9	1	1	5	0	3	0	0	0.163	0.955	1.000
88	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT2(1), OXCT1(1)	4027384	2	2	2	0	0	1	0	1	0	0	0.592	0.956	1.000
89	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(3), BAK1(2), BAX(1), BCL2(2), BCL2L11(1), CASP9(1), CES1(3)	13075810	13	11	13	1	5	1	1	3	3	0	0.111	0.956	1.000
90	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	10	ATM(12), CDC25A(1), CDC25B(1), CDK2(1), CDK4(1), CHEK1(6), MYT1(7), WEE1(2), YWHAH(2)	17903821	33	22	33	6	5	2	6	7	13	0	0.291	0.959	1.000
91	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	EGR1(5), MAP2K1(1), MAP2K2(1), MAPK1(4), MAPK3(2), NGFR(1), RAF1(2)	9837313	16	12	15	3	3	4	3	1	4	1	0.104	0.959	1.000
92	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	GGT1(3), SHMT1(2)	6606201	5	5	5	1	1	2	2	0	0	0	0.330	0.960	1.000
93	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD28(2), CD86(3), HLA-DRA(4), HLA-DRB1(1), IFNG(2), IFNGR1(1), IFNGR2(4), IL12B(4), IL12RB1(4), IL12RB2(4), IL18(3), IL18R1(4), IL4R(10)	15106484	46	38	45	13	15	2	5	16	8	0	0.202	0.960	1.000
94	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(1), AASDHPPT(1), AASS(1), KARS(2)	5630801	5	5	5	2	2	0	0	2	1	0	0.767	0.961	1.000
95	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(1), ACADM(2), ACADS(5), ECHS1(3), HADHA(3)	6442085	14	11	13	5	4	3	1	2	4	0	0.438	0.961	1.000
96	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	16	CSNK2A1(2), ELK1(5), FOS(2), MAP2K1(1), MAPK3(2), MAPK8(2), NGFR(1), PLCG1(12), RAF1(2), SHC1(1), SOS1(7)	18297015	37	30	35	7	5	9	5	10	7	1	0.0461	0.963	1.000
97	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(1), COASY(2), DPYD(6), DPYS(5), ENPP1(5), ENPP3(2), ILVBL(5), PANK2(1), PANK4(4), VNN1(2)	20591021	33	26	32	6	7	6	1	13	6	0	0.147	0.964	1.000
98	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(4), CYP2A13(2), CYP2A7(1), NAT1(1), NAT2(3), XDH(11)	9491348	22	17	22	6	6	5	1	7	3	0	0.239	0.968	1.000
99	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	14	CD28(2), CD3D(1), CD3E(2), CD3G(1), CD86(3), CTLA4(1), HLA-DRA(4), HLA-DRB1(1), ICOS(1), ITK(1), LCK(1)	9286953	18	15	17	5	6	3	2	4	3	0	0.381	0.969	1.000
100	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(9), CD44(6), FCGR3A(1), IL1B(3), IL6R(1), SPN(1), TGFB2(2), TNF(1), TNFRSF1A(1), TNFRSF1B(3), TNFRSF8(4), TNFSF8(3)	15720656	35	27	34	8	13	7	3	5	7	0	0.0423	0.971	1.000
101	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(2), HK1(4), HK2(5), HK3(5), PGM1(1), PGM3(1), TGDS(2)	12178921	20	15	20	3	10	5	2	2	1	0	0.0328	0.973	1.000
102	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNAR1(2), IFNAR2(2), IFNB1(2), JAK1(3), STAT1(4), STAT2(2), TYK2(10)	12928260	25	18	25	5	7	1	1	10	5	1	0.193	0.975	1.000
103	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	AANAT(2), ACHE(2), CHAT(6), DBH(4), DDC(6), GAD1(3), GAD2(1), HDC(5), MAOA(3), PAH(4), SLC18A3(1), TH(3), TPH1(6)	17169810	46	34	45	13	22	9	2	11	2	0	0.0661	0.975	1.000
104	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(2), CHAT(6), PCYT1A(2), PDHA1(6), PDHA2(7), SLC18A3(1)	8321957	24	19	22	9	7	8	2	3	4	0	0.283	0.975	1.000
105	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	CREB1(2), FOS(2), MAPK1(4), MAPK8(2), NFE2L2(1), PRKCA(6)	10584874	17	13	17	4	3	3	4	2	4	1	0.178	0.977	1.000
106	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(3), ECHS1(3), EHHADH(2), HADHA(3), SDS(1)	5756783	12	9	12	7	3	3	2	1	3	0	0.746	0.980	1.000
107	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(1), CYCS(2), GPD2(2), SDHA(4), SDHC(2), UQCRC1(4)	7873542	15	11	14	4	2	3	5	4	1	0	0.301	0.981	1.000
108	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(2), CYP11A1(7), CYP11B2(3), HSD11B1(2), HSD3B1(2), HSD3B2(1)	8219779	17	17	17	6	9	3	1	1	3	0	0.331	0.981	1.000
109	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT2(1), BDH1(1), BDH2(1), HMGCS1(2), HMGCS2(3), OXCT1(1), OXCT2(1)	8553810	10	5	10	1	2	3	0	4	1	0	0.188	0.982	1.000
110	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	13	AKT1(2), IGF1R(10), IRS1(8), MAP2K1(1), MAPK1(4), MAPK3(2), RAF1(2), SHC1(1), SOS1(7), YWHAH(2)	18090949	39	33	39	9	7	5	8	7	11	1	0.123	0.984	1.000
111	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(2), ENO2(2), ENO3(3), FARS2(3), GOT1(2), GOT2(1), PAH(4), TAT(3), YARS(1)	9880099	21	13	20	4	11	4	1	3	2	0	0.133	0.984	1.000
112	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	FOSB(2), GRIA2(2), PPP1R1B(1)	4508658	5	4	5	2	3	0	0	2	0	0	0.588	0.985	1.000
113	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	16	ACE(9), ACE2(7), AGT(3), AGTR1(1), AGTR2(4), ANPEP(5), CTSA(1), CTSG(5), ENPEP(10), LNPEP(4), MME(3), NLN(1), REN(7), THOP1(5)	24647294	65	50	61	13	21	9	7	15	13	0	0.0184	0.986	1.000
114	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(2), CDC25A(1), CDC25B(1), CSK(2), PRKCA(6), PTPRA(7), SRC(2)	10972521	21	14	21	4	9	4	3	3	1	1	0.0768	0.986	1.000
115	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	10	AKT1(2), NTRK1(3), PLCG1(12), PRKCA(6), SHC1(1), SOS1(7)	14053871	31	26	29	8	6	4	5	9	6	1	0.240	0.987	1.000
116	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNB1(2), IFNG(2), IL10(1), IL12B(4), IL15(2), IL16(9), IL18(3), IL1A(1), IL3(2), IL5(1), IL6(2), IL9(1), TNF(1)	11814808	31	24	31	10	5	4	5	12	5	0	0.453	0.988	1.000
117	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(15), MAP2(8), PPP1CA(1), PPP2CA(4), PRKACG(1), PRKAG1(1), PRKAR2B(1), PRKCE(1)	21670277	32	19	32	4	4	5	4	9	10	0	0.0973	0.988	1.000
118	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	20	CEBPB(2), CSNK2A1(2), ELK1(5), FOS(2), IL6(2), IL6R(1), IL6ST(3), JAK1(3), JAK2(5), JAK3(5), MAP2K1(1), MAPK3(2), RAF1(2), SHC1(1), SOS1(7), SRF(3), STAT3(3)	27080409	49	37	49	8	10	10	3	15	10	1	0.0185	0.990	1.000
119	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(2), HK1(4), HK2(5), HK3(5), ISYNA1(2), PGM1(1), PGM3(1), TGDS(2)	13913828	22	16	22	3	10	6	2	3	1	0	0.0171	0.990	1.000
120	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(1), LCMT1(3), LCMT2(2), METTL2B(3), METTL6(2), PCYT1A(2), PCYT1B(2), PRMT2(2), PRMT5(4), PRMT6(1), PRMT7(1), PRMT8(5), WBSCR22(2)	16787940	30	18	30	7	7	3	5	8	7	0	0.180	0.991	1.000
121	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(2), GCK(2), GFPT1(5), GNPDA1(3), HEXA(1), HEXB(1), HK1(4), HK2(5), HK3(5), PGM3(1), RENBP(4), UAP1(2)	20186983	35	26	35	5	12	7	5	7	4	0	0.0175	0.991	1.000
122	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	12	AKT1(2), CASP9(1), CHUK(1), GH1(2), GHR(4), NFKB1(2), NFKBIA(3), PPP2CA(4), RELA(1), YWHAH(2)	12298750	22	15	22	6	4	4	2	8	4	0	0.339	0.992	1.000
123	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	CBS(5), CTH(2), GGT1(3), MARS(7), MARS2(2), MAT1A(2), SCLY(3), SEPHS1(1)	14746887	25	16	25	4	5	8	3	6	3	0	0.0481	0.992	1.000
124	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTR2(2), ACTR3(1), ARPC1A(1), ARPC1B(2), ARPC2(1), ARPC3(1), ARPC4(1), RAC1(1), WASF1(1), WASL(2)	9687905	13	7	13	4	0	2	1	7	3	0	0.674	0.992	1.000
125	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(5), FHL5(3), FSHR(3), GNAS(4), XPO1(1)	11430342	16	15	16	4	5	3	3	3	2	0	0.390	0.992	1.000
126	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(6), GALNT10(1), GALNT2(3), GALNT3(1), GALNT4(3), GALNT6(4), GALNT7(2), GALNT8(1), GALNT9(4), GCNT1(2), ST3GAL1(3), ST3GAL2(1), ST3GAL4(3), WBSCR17(11)	17186858	45	34	45	11	16	7	5	10	7	0	0.136	0.992	1.000
127	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(2), F2(4), F2R(2), F5(13), F7(2), FGA(12), FGB(4), FGG(6), PROS1(3), SERPINC1(2)	19518047	50	45	49	14	15	7	10	12	6	0	0.150	0.992	1.000
128	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	CISH(1), IL6(2), IL6R(1), JAK1(3), JAK2(5), JAK3(5), PIAS3(3), PTPRU(3), REG1A(2), SRC(2), STAT3(3)	18210688	30	25	30	7	7	3	2	10	8	0	0.201	0.993	1.000
129	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(3), BIRC2(3), BIRC3(1), CASP10(1), CASP8(2), CASP9(1), DFFA(2), GZMB(3), PRF1(3), SCAP(3), SREBF1(7), SREBF2(4)	21811833	33	27	33	7	11	7	6	7	2	0	0.0849	0.993	1.000
130	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(4), LCT(13), MPI(2), PGM1(1), PYGL(6), PYGM(2), TPI1(1)	15987694	29	20	29	7	9	6	3	5	6	0	0.0834	0.994	1.000
131	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	CARM1(1), DHRS2(2), DHRS3(1), DHRS7(1), DHRSX(1), LCMT1(3), LCMT2(2), METTL2B(3), METTL6(2), PRMT2(2), PRMT5(4), PRMT6(1), PRMT7(1), PRMT8(5), WBSCR22(2)	17901293	31	17	30	8	9	3	6	7	6	0	0.192	0.994	1.000
132	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(2), PLCD1(4), PRKCA(6), TGM2(1)	5912299	13	10	13	5	5	0	1	6	0	1	0.585	0.994	1.000
133	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(1), ACADM(2), ACADS(5), ACADVL(3), ACSL1(4), ACSL3(3), ACSL4(6), CPT1A(2), CPT2(2), EHHADH(2), HADHA(3), PECR(2), SCP2(1), SLC25A20(1)	20040340	37	25	36	9	6	8	3	8	12	0	0.136	0.994	1.000
134	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	19	AKT1(2), CCND1(4), CCNE1(2), CDK2(1), CDK4(1), CDK6(1), CDKN1A(2), CDKN1B(4), E2F1(1), MAPK1(4), MAPK3(2), NFKB1(2), NFKBIA(3), PAK1(3), RAC1(1), RAF1(2), RELA(1), TFDP1(1)	17524307	37	26	36	7	8	4	7	6	11	1	0.0552	0.994	1.000
135	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	17	CSNK2A1(2), ELK1(5), FOS(2), IGF1(3), IGF1R(10), IRS1(8), MAP2K1(1), MAPK3(2), MAPK8(2), RAF1(2), RASA1(4), SHC1(1), SOS1(7), SRF(3)	23619566	52	43	52	13	10	10	8	11	12	1	0.106	0.994	1.000
136	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP1(1), ACP6(2), ACPP(4), ACPT(2), ALPI(2), ALPP(7), ALPPL2(6), CYP3A4(5), CYP3A43(1), CYP3A5(4), CYP3A7(3), DHRS2(2), DHRS3(1), DHRS7(1), DHRSX(1), PON1(4), PON3(1)	21450002	47	41	44	12	24	3	5	8	7	0	0.0771	0.995	1.000
137	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(4), ME1(2), PC(4), PDHA1(6), SLC25A1(1), SLC25A11(1)	11040346	18	17	16	5	2	4	0	7	5	0	0.371	0.995	1.000
138	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	B3GALT1(2), B3GALT2(1), B3GALT5(2), B3GNT5(4), FUT1(1), FUT2(2), FUT3(2), ST3GAL3(2), ST3GAL4(3)	8592885	19	13	19	6	9	0	1	6	3	0	0.441	0.995	1.000
139	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	CYP51A1(2), DHCR7(4), FDFT1(1), FDPS(3), HMGCS1(2), IDI1(2), LSS(1), MVD(4), MVK(1), NSDHL(2), SQLE(1)	15750873	23	15	23	6	8	1	5	6	3	0	0.345	0.995	1.000
140	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(17), CPT1A(2), LEPR(3), PRKAA1(3), PRKAA2(2), PRKAG1(1), PRKAG2(2)	17246485	30	18	30	4	10	3	1	9	7	0	0.0540	0.995	1.000
141	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD28(2), CD4(2), HLA-DRA(4), HLA-DRB1(1), IL10(1)	4740068	10	8	9	5	4	1	1	3	1	0	0.686	0.996	1.000
142	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(4), APOBEC1(6), APOBEC2(1), APOBEC3B(2), APOBEC3C(1), APOBEC3F(4), APOBEC3G(2), APOBEC4(1)	8727202	21	20	21	7	8	3	2	6	2	0	0.445	0.996	1.000
143	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(2), LDLR(3), MBTPS1(2), MBTPS2(3), SCAP(3), SREBF1(7), SREBF2(4)	14318173	24	18	24	7	5	5	3	8	3	0	0.356	0.996	1.000
144	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(4), GLS2(1), GLUD1(5), GLUD2(4)	5417308	14	12	14	5	3	2	0	6	3	0	0.635	0.996	1.000
145	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(2), CD8A(1), CSF2(2), EPO(2), IL3(2), IL5(1), IL6(2), IL7(1), IL9(1)	7238643	14	12	14	7	3	2	1	5	3	0	0.776	0.996	1.000
146	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(2), CCNH(2), CDC25A(1), CDC25B(1), CDK7(1), SHH(3), XPO1(1)	10365044	11	8	11	3	5	5	1	0	0	0	0.281	0.997	1.000
147	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	18	APAF1(3), BAK1(2), BAX(1), BCL2(2), BIRC2(3), BIRC3(1), CASP8(2), CASP9(1), CYCS(2), DFFA(2), DIABLO(1)	16001159	20	16	20	5	4	4	3	6	3	0	0.365	0.997	1.000
148	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(6), ACO2(4), AFMID(1), HAO1(4), HAO2(3), HYI(3), MTHFD1(3), MTHFD1L(1)	15940076	25	17	25	5	4	5	4	6	6	0	0.161	0.997	1.000
149	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(1), CAT(3), EPX(7), LPO(5), MPO(4), MTHFR(7), SHMT1(2), TPO(10)	13846519	39	22	39	10	17	9	4	6	3	0	0.0698	0.997	1.000
150	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	4	EGF(10), ERBB3(4), NRG1(5)	9120827	19	15	19	6	7	2	0	5	5	0	0.590	0.997	1.000
151	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	RAB27A(2), RAB3A(1), RAB9A(1)	5072962	4	3	4	2	2	1	0	1	0	0	0.767	0.997	1.000
152	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	20	ADCY1(5), AKT1(2), BAX(1), BCL2(2), CSF2RB(6), IGF1(3), IGF1R(10), IL3(2), IL3RA(4), KIT(9), KITLG(3), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), YWHAH(2)	21654412	54	42	53	12	17	3	9	13	12	0	0.0571	0.997	1.000
153	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(2), IFNB1(2), JAK1(3), PTPRU(3), REG1A(2), STAT1(4), STAT2(2), TYK2(10)	14900635	28	21	28	8	8	1	1	9	8	1	0.342	0.998	1.000
154	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(3), ARHGAP5(5), ARHGDIB(1), CASP1(7), CASP10(1), CASP8(2), CASP9(1), CYCS(2), GZMB(3), PRF1(3)	15340754	28	22	27	9	6	6	3	11	2	0	0.453	0.998	1.000
155	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	15	ADRB2(1), AKT1(2), ANXA1(2), CALM1(1), CALM3(1), GNAS(4), GNB1(1), NFKB1(2), NOS3(10), NPPA(2), NR3C1(3), RELA(1), SYT1(3)	16931438	33	25	33	9	14	3	5	7	4	0	0.295	0.998	1.000
156	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(5), GNAS(4), GNB1(1), PRKAR1A(2)	7880541	12	12	12	4	6	1	0	3	2	0	0.631	0.998	1.000
157	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(6), ACO2(4), HAO1(4), HAO2(3), HYI(3), MTHFD1(3), MTHFD1L(1)	15219396	24	16	24	5	4	5	4	6	5	0	0.164	0.998	1.000
158	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(4), F2R(2), F2RL3(3), GNAI1(4), GNB1(1), ITGA1(4), ITGB1(3), MAP2K1(1), MAPK1(4), MAPK3(2), PLA2G4A(7), PLCB1(4), PRKCA(6), PTGS1(3), PTK2(2), RAF1(2), SRC(2), TBXAS1(3)	29066539	57	44	57	11	13	3	11	20	8	2	0.0423	0.998	1.000
159	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(1), CDKN1A(2), EPO(2), EPOR(1), GRIN1(2), JAK2(5), NFKB1(2), NFKBIA(3), RELA(1), SOD2(1)	15106831	20	14	20	5	5	2	1	8	4	0	0.338	0.998	1.000
160	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(1), PSMA2(2), PSMA3(2), PSMA4(1), PSMA5(1), PSMB1(1), PSMB2(1), PSMB3(1), PSMB4(1), PSMB5(1), PSMB6(1), PSMB8(3)	10398868	16	9	16	3	4	5	3	3	1	0	0.185	0.998	1.000
161	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(13), EP300(6), ESR1(3), MAPK1(4), MAPK3(2), PELP1(2), SRC(2)	17587538	32	21	31	7	10	4	4	7	6	1	0.118	0.998	1.000
162	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(2), BLVRA(2), CP(7), EPRS(5), FECH(2), GUSB(3), HCCS(5), HMBS(1), HMOX1(1), PPOX(2), UGT1A1(5), UGT1A10(2), UGT1A3(3), UGT1A4(1), UGT1A5(3), UGT1A6(4), UGT1A7(3), UGT1A9(2), UGT2B15(3), UGT2B4(10), UROD(1), UROS(1)	32616146	68	53	67	15	18	9	14	22	5	0	0.0318	0.998	1.000
163	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(4), FDFT1(1), FDPS(3), IDI1(2), LSS(1), MVD(4), MVK(1), NQO1(1), NQO2(1), SQLE(1)	13220426	19	12	19	5	6	1	5	4	3	0	0.343	0.998	1.000
164	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(2), ALDH1A2(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6)	9531332	20	14	20	7	10	3	2	3	2	0	0.359	0.998	1.000
165	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(2), ALDH1A2(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6)	9531332	20	14	20	7	10	3	2	3	2	0	0.359	0.998	1.000
166	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ERBB4(5), NRG2(1), PRKCA(6), PSEN1(1)	10734263	13	9	13	3	4	1	2	4	1	1	0.350	0.998	1.000
167	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(2), CD3D(1), CD3E(2), CD3G(1), IFNG(2), TGFB2(2), TGFB3(1), TGFBR1(4), TGFBR2(5), TGFBR3(3), TOB1(1), TOB2(1)	12596930	25	18	24	6	6	7	4	5	3	0	0.119	0.998	1.000
168	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CDO1(1), CTH(2), GOT1(2), GOT2(1), LDHA(1), LDHAL6A(1), LDHAL6B(2), LDHB(2), LDHC(1), SDS(1), SULT1B1(9), SULT1C2(3)	14932952	26	18	26	7	3	8	2	10	3	0	0.350	0.999	1.000
169	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BAG4(1), BIRC3(1), CASP8(2), RIPK1(4), TNF(1), TNFRSF1A(1), TNFRSF1B(3), TRADD(1), TRAF2(2)	10028172	16	15	16	6	5	3	2	3	3	0	0.557	0.999	1.000
170	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	19	F10(2), F12(1), F13B(5), F2(4), F5(13), F7(2), F8(26), FGA(12), FGB(4), FGG(6), LPA(11), PLAT(3), PLG(6), SERPINB2(3), SERPINE1(4), SERPINF2(1), VWF(14)	40927085	117	83	116	26	32	22	15	30	18	0	0.00282	0.999	1.000
171	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(1), SULT1A2(1), SULT2A1(2), SUOX(2)	7268659	6	3	6	5	0	1	0	3	2	0	0.970	0.999	1.000
172	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	FUT1(1), FUT2(2), GCNT2(1), ST8SIA1(2)	7326957	6	4	6	6	2	0	0	1	3	0	0.995	0.999	1.000
173	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	18	ACO1(6), ACO2(4), DLD(3), FH(1), IDH3A(1), IDH3B(1), PC(4), PCK1(6), SDHA(4), SUCLA2(1), SUCLG1(2), SUCLG2(1)	22581877	34	27	33	6	8	9	5	9	3	0	0.0327	0.999	1.000
174	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(1), IFNG(2), IFNGR1(1), JAK1(3), JAK2(5), PTPRU(3), REG1A(2), STAT1(4)	13627061	21	15	21	7	3	1	2	7	7	1	0.502	0.999	1.000
175	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	12	AKT1(2), BCL2(2), IGF1R(10), POLR2A(9), PPP2CA(4), PRKCA(6), TEP1(12), TERF1(1), TERT(6), TNKS(2), XRCC5(4)	27389260	58	42	58	14	21	5	9	14	8	1	0.0491	0.999	1.000
176	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	ST3GAL1(3), ST3GAL2(1), ST3GAL4(3), ST6GALNAC4(1), ST8SIA1(2)	6726929	10	10	10	5	4	0	1	3	2	0	0.839	0.999	1.000
177	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH7A1(2), MIOX(1), UGDH(1)	10174884	20	12	20	5	11	2	2	3	2	0	0.184	0.999	1.000
178	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	4	DLL1(1), FURIN(1), PSEN1(1)	6220100	3	3	3	2	1	0	0	1	1	0	0.948	0.999	1.000
179	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(3), ECHS1(3), HADHA(3), HSD17B4(3), MECR(2), PPT2(2)	10107873	16	12	16	6	2	3	2	4	5	0	0.641	0.999	1.000
180	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(1), AASDH(3), AASDHPPT(1), AASS(1), KARS(2)	8299669	8	7	8	4	2	0	1	3	2	0	0.880	0.999	1.000
181	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(5), ADRB2(1), CFTR(6), GNAS(4), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), SLC9A3R1(1)	15626565	22	20	22	5	11	3	1	4	3	0	0.224	0.999	1.000
182	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(1), F13A1(5), F2(4), F2R(2), FGA(12), FGB(4), FGG(6), PLAT(3), PLG(6), SERPINB2(3), SERPINE1(4)	15959346	50	43	49	16	15	9	7	13	6	0	0.284	0.999	1.000
183	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	16	B3GAT1(1), CHPF(1), CHST11(3), CHST13(3), CHST3(3), CHSY1(4), DSE(6), UST(1), XYLT1(3), XYLT2(4)	16740174	29	23	29	6	11	4	2	8	4	0	0.0666	0.999	1.000
184	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	MMP9(4), RECK(4), TIMP1(1), TIMP3(2), TIMP4(2)	8969543	13	10	13	5	5	2	1	3	2	0	0.575	0.999	1.000
185	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(5), ADRB2(1), GNAS(4), PLCE1(10), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), RAP2B(4)	17630591	29	24	29	7	13	6	2	3	5	0	0.163	0.999	1.000
186	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(6), FOS(2), IL3(2), IL3RA(4), JAK2(5), MAP2K1(1), MAPK3(2), PTPN6(1), RAF1(2), SHC1(1), SOS1(7), STAT5A(1), STAT5B(2)	21077623	36	27	35	9	10	3	5	11	6	1	0.221	0.999	1.000
187	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(3), ASNS(5), CA1(1), CA12(3), CA14(1), CA2(1), CA5A(2), CA9(1), CPS1(8), CTH(2), GLS(4), GLS2(1), GLUD1(5), GLUL(2), HAL(3)	22643084	42	32	42	10	12	8	3	11	8	0	0.124	0.999	1.000
188	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT2(1), ACYP1(1), ECHS1(3), EHHADH(2), GCDH(1), HADHA(3), SDS(1)	9287003	12	10	12	9	2	4	1	2	3	0	0.926	0.999	1.000
189	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(2), AKR1D1(1), CYP11A1(7), CYP11B1(2), CYP11B2(3), CYP21A2(1), HSD11B1(2), HSD3B1(2), HSD3B2(1)	11048176	21	20	21	7	9	3	2	3	4	0	0.364	1.000	1.000
190	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(2), AKR1D1(1), CYP11A1(7), CYP11B1(2), CYP11B2(3), CYP21A2(1), HSD11B1(2), HSD3B1(2), HSD3B2(1)	11048176	21	20	21	7	9	3	2	3	4	0	0.364	1.000	1.000
191	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	28	ATG12(2), ATG5(4), ATG7(3), IFNA10(2), IFNA5(1), IFNA6(1), IFNA7(1), IFNA8(1), IFNG(2), INS(1), PIK3C3(2), PIK3R4(3), PRKAA1(3), PRKAA2(2), ULK1(2), ULK2(7)	24691398	37	20	36	6	7	4	7	10	9	0	0.0341	1.000	1.000
192	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA10(4), NDUFA4(1), NDUFB5(1), NDUFS1(2), NDUFS2(1), NDUFV1(2), NDUFV2(1)	8306114	12	7	12	5	0	1	2	5	4	0	0.818	1.000	1.000
193	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	16	DNAJA3(3), IFNG(2), IFNGR1(1), IFNGR2(4), IKBKB(2), JAK2(5), NFKB1(2), NFKBIA(3), RELA(1), TNF(1), TNFRSF1A(1), TNFRSF1B(3), USH1C(3), WT1(3)	18642897	34	24	34	9	6	4	5	12	7	0	0.222	1.000	1.000
194	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(2), GNAS(4), GNB1(1), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), PRKCA(6)	11476205	18	15	18	5	8	0	1	6	2	1	0.577	1.000	1.000
195	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	21	COL4A1(4), COL4A2(8), COL4A3(1), COL4A4(11), COL4A5(12), COL4A6(9), F10(2), F12(1), F2(4), F2R(2), F5(13), F8(26), FGA(12), FGB(4), FGG(6), KLKB1(7), PROS1(3), SERPINC1(2), SERPING1(4)	51942752	131	97	129	30	30	28	21	32	19	1	0.00240	1.000	1.000
196	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	6	ATM(12), ATR(10), CHEK1(6), CHEK2(3), YWHAH(2)	18106034	33	22	33	7	5	6	7	8	7	0	0.261	1.000	1.000
197	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	19	ARFIP2(2), CFL1(1), LIMK1(4), MAP3K1(10), MYL2(2), MYLK(7), NCF2(6), PAK1(3), PLD1(8), PPP1R12B(1), RAC1(1), RALBP1(3), RPS6KB1(2), TRIO(7), VAV1(9), WASF1(1)	34453616	67	47	64	12	17	9	12	16	13	0	0.00557	1.000	1.000
198	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	AKR1A1(3), ECHS1(3), EHHADH(2), HADHA(3), HSD17B4(3), SIRT1(1), SIRT2(1), SIRT5(3), SIRT7(1), VNN2(1)	14115375	21	17	21	9	5	3	2	5	6	0	0.715	1.000	1.000
199	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	19	AKT1(2), APAF1(3), ATM(12), BAX(1), BCL2(2), CASP9(1), CYCS(2), PRKCA(6), PTK2(2), PXN(1), STAT1(4), TLN1(5)	31696291	41	29	41	8	7	2	6	14	10	2	0.151	1.000	1.000
200	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	NFKB1(2), NFKBIA(3), PLCB1(4), PRKCA(6), RELA(1)	9818309	16	13	16	8	5	0	1	7	2	1	0.855	1.000	1.000
201	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CCL2(1), IL1B(3), MST1R(4), TNF(1)	7818282	9	7	9	4	2	3	0	2	2	0	0.642	1.000	1.000
202	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(15), ABCB11(3), ABCB4(12), ABCC1(6), ABCC3(7)	17095008	43	32	42	14	12	7	4	12	7	1	0.312	1.000	1.000
203	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	CREB1(2), PTK2B(5), SHC1(1), SOS1(7), SRC(2)	10523469	17	15	17	5	3	2	1	6	5	0	0.411	1.000	1.000
204	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	HS3ST1(3), HS3ST3A1(3), XYLT1(3), XYLT2(4)	7869006	13	12	13	5	7	2	3	1	0	0	0.452	1.000	1.000
205	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	HS3ST1(3), HS3ST3A1(3), XYLT1(3), XYLT2(4)	7869006	13	12	13	5	7	2	3	1	0	0	0.452	1.000	1.000
206	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(4), BMPR1A(1), BMPR1B(1), BMPR2(1)	7488470	7	6	7	6	3	0	2	1	1	0	0.987	1.000	1.000
207	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	12	ABL1(6), CDKN2A(6), E2F1(1), MDM2(5), POLR1A(7), POLR1B(3), RAC1(1), TBX2(1)	16562925	30	18	29	9	7	3	4	7	9	0	0.284	1.000	1.000
208	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	AOC2(1), CES1(3)	7200574	4	4	4	2	3	1	0	0	0	0	0.632	1.000	1.000
209	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	C1GALT1(1), GALNT1(6), GALNT10(1), GALNT11(3), GALNT12(3), GALNT13(4), GALNT14(7), GALNT2(3), GALNT3(1), GALNT4(3), GALNT5(5), GALNT6(4), GALNT7(2), GALNT8(1), GALNT9(4), GALNTL5(1), GCNT1(2), GCNT3(2), GCNT4(3), OGT(9), ST3GAL1(3), ST3GAL2(1), ST6GALNAC1(2), WBSCR17(11)	38507466	82	60	81	19	28	14	6	21	13	0	0.0488	1.000	1.000
210	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(3), ARHGDIB(1), BIRC2(3), BIRC3(1), CASP1(7), CASP10(1), CASP2(1), CASP4(1), CASP8(2), CASP9(1), CYCS(2), DFFA(2), GZMB(3), LMNA(2), LMNB2(3), PRF1(3)	23038887	36	25	36	9	9	8	6	10	3	0	0.184	1.000	1.000
211	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	12	CREB1(2), FOS(2), MAPK3(2), POLR2A(9), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1)	14494491	20	17	20	6	6	2	1	6	4	1	0.452	1.000	1.000
212	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1A(2), ADRA1B(2), ADRA2A(1), ADRA2C(3), ADRB2(1), CHRM1(3), CHRM2(3), CHRM3(4), CHRM4(3), CHRM5(4), DRD1(1), DRD2(1), DRD3(3), DRD5(10), HRH1(3), HRH2(3), HTR1A(2), HTR1B(3), HTR1D(3), HTR1E(3), HTR1F(3), HTR2A(2), HTR2B(2), HTR2C(4), HTR4(2), HTR5A(8), HTR6(1), HTR7(4)	30609203	84	65	82	20	47	12	6	12	7	0	0.000322	1.000	1.000
213	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(1), PSMA2(2), PSMA3(2), PSMA4(1), PSMA5(1), PSMB1(1), PSMB2(1), PSMB3(1), PSMB4(1), PSMB5(1), PSMB6(1), PSMC2(1), PSMC3(2), PSMD1(1), PSMD11(2), PSMD2(3)	19055645	22	12	22	4	3	9	3	4	3	0	0.129	1.000	1.000
214	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(3), FARSA(1), GOT1(2), GOT2(1), PAH(4), TAT(3), YARS(1), YARS2(1)	10381876	16	13	15	5	6	5	1	3	1	0	0.431	1.000	1.000
215	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(3), ATP6V0A4(3), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(1), ATP6V1G1(1), ATP6V1G3(2), ATP6V1H(1), SHMT1(2)	17952570	24	20	24	7	7	7	4	5	0	1	0.242	1.000	1.000
216	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(3), ATP6V0A4(3), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(1), ATP6V1G1(1), ATP6V1G3(2), ATP6V1H(1), SHMT1(2)	17952570	24	20	24	7	7	7	4	5	0	1	0.242	1.000	1.000
217	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(3), ATP6V0A4(3), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(1), ATP6V1G1(1), ATP6V1G3(2), ATP6V1H(1), SHMT1(2)	17952570	24	20	24	7	7	7	4	5	0	1	0.242	1.000	1.000
218	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	ATM(12), BMPR1B(1), CCND2(2), CDK4(1), CDKN1B(4), CEBPB(2), DMC1(2), EGR1(5), ESR2(6), FSHR(3), GJA4(1), LHCGR(2), MLH1(4), MSH5(4), NCOR1(10), NR5A1(1), NRIP1(4), PGR(9), PRLR(2), SMPD1(2), VDR(2), ZP2(6)	41821489	85	59	84	21	15	18	10	24	17	1	0.174	1.000	1.000
219	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	23	CSNK2A1(2), ELK1(5), FOS(2), JAK1(3), MAP2K1(1), MAP3K1(10), MAPK3(2), MAPK8(2), PDGFA(1), PLCG1(12), PRKCA(6), RAF1(2), RASA1(4), SHC1(1), SOS1(7), SRF(3), STAT1(4), STAT3(3), STAT5A(1)	34471206	71	54	67	15	15	16	8	18	11	3	0.0188	1.000	1.000
220	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	F13B(5), HSD17B3(1), HSD17B4(3), HSD17B7(2), HSD3B1(2), HSD3B2(1)	9644954	14	14	13	7	2	5	3	2	2	0	0.696	1.000	1.000
221	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(1), ACACA(17), ACACB(18), ACADM(2), ACAT2(1), ACSS1(1), ACSS2(4), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH6A1(5), ALDH7A1(2), ECHS1(3), EHHADH(2), HADHA(3), HIBCH(2), LDHA(1), LDHAL6A(1), LDHAL6B(2), LDHB(2), LDHC(1), MLYCD(4), MUT(2), PCCA(3), PCCB(4), SUCLA2(1), SUCLG1(2), SUCLG2(1)	47266285	101	65	101	21	33	23	8	24	13	0	0.00410	1.000	1.000
222	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	19	AKT1(2), CASP9(1), CHUK(1), ELK1(5), H2AFX(1), MAP2K1(1), MAPK3(2), NFKB1(2), RAC1(1), RAF1(2), RALA(2), RALBP1(3), RALGDS(4), RELA(1)	18291440	28	18	28	9	5	2	4	6	10	1	0.409	1.000	1.000
223	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	23	CSNK2A1(2), EGF(10), ELK1(5), FOS(2), JAK1(3), MAP2K1(1), MAP3K1(10), MAPK3(2), MAPK8(2), PLCG1(12), PRKCA(6), RAF1(2), RASA1(4), SHC1(1), SOS1(7), SRF(3), STAT1(4), STAT3(3), STAT5A(1)	37052044	80	61	76	20	18	17	8	22	12	3	0.0680	1.000	1.000
224	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	11	CREBBP(13), DAXX(5), PAX3(4), PML(3), SIRT1(1), SP100(6), TNF(1), TNFRSF1A(1), TNFRSF1B(3)	19677849	37	24	37	8	8	6	4	12	7	0	0.133	1.000	1.000
225	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	CALM1(1), CALM3(1), CDKN1A(2), MARCKS(1), NFATC1(2), NFATC2(7), NFATC3(3), NFATC4(5), PLCG1(12), PPP3CA(1), PPP3CB(1), PPP3CC(1), PRKCA(6), SP1(1), SP3(5), SYT1(3)	25002327	52	37	50	13	13	9	8	13	8	1	0.0792	1.000	1.000
226	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	20	CSNK2A1(2), FOS(2), JAK2(5), MAP2K1(1), MAPK3(2), MPL(5), PLCG1(12), PRKCA(6), RAF1(2), RASA1(4), SHC1(1), SOS1(7), STAT1(4), STAT3(3), STAT5A(1), STAT5B(2), THPO(2)	31213982	61	46	59	12	15	9	7	18	9	3	0.0267	1.000	1.000
227	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ARG2(2), ASL(2), CKB(1), CKM(3), CKMT1A(2), CKMT1B(4), CKMT2(1), CPS1(8), GAMT(1), GATM(2), GLUD1(5), NAGS(1), OAT(1), ODC1(3), OTC(2), SMS(1)	20898709	39	27	39	10	9	6	4	11	9	0	0.251	1.000	1.000
228	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(13), EP300(6), LPL(2), NCOA1(3), NCOA2(5), PPARG(3), RXRA(4)	22020373	36	27	35	10	9	7	2	11	7	0	0.307	1.000	1.000
229	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(2), ELK1(5), EPO(2), EPOR(1), FOS(2), JAK2(5), MAP2K1(1), MAPK3(2), MAPK8(2), PLCG1(12), PTPN6(1), RAF1(2), SHC1(1), SOS1(7), STAT5A(1), STAT5B(2)	25656722	48	37	46	12	7	9	7	15	9	1	0.114	1.000	1.000
230	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	GLB1(2), GUSB(3), HEXA(1), HEXB(1), HGSNAT(3), HPSE(5), HPSE2(5), HYAL1(3), HYAL2(2), IDS(2), LCT(13), NAGLU(3), SPAM1(7)	24472423	50	36	48	13	23	5	6	10	6	0	0.126	1.000	1.000
231	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	20	ATM(12), ATR(10), BRCA1(6), BRCA2(13), CHEK1(6), CHEK2(3), FANCA(4), FANCC(1), FANCD2(10), FANCE(2), HUS1(1), MRE11A(3), RAD1(2), RAD17(2), RAD50(6), RAD9A(3), TREX1(2)	51630553	86	57	85	15	19	19	17	20	11	0	0.00596	1.000	1.000
232	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(2), IL4R(10), IRS1(8), JAK1(3), JAK3(5), RPS6KB1(2), SHC1(1), STAT6(5)	17685020	36	31	36	10	9	4	2	11	10	0	0.302	1.000	1.000
233	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(2), DAG1(3)	7265801	5	5	5	3	1	1	3	0	0	0	0.779	1.000	1.000
234	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	11	ACE2(7), AGT(3), AGTR1(1), AGTR2(4), COL4A1(4), COL4A2(8), COL4A3(1), COL4A4(11), COL4A5(12), COL4A6(9), REN(7)	29556950	67	47	64	21	17	18	8	13	10	1	0.171	1.000	1.000
235	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	CHIA(2), CMAS(2), CYB5R1(1), GFPT1(5), GFPT2(3), GNPDA1(3), GNPNAT1(2), HEXA(1), HEXB(1), HK1(4), HK2(5), HK3(5), LHPP(1), MTMR1(6), MTMR2(3), MTMR6(1), NANS(1), NPL(1), PGM3(1), RENBP(4), UAP1(2)	34184299	54	41	54	12	15	9	10	12	8	0	0.0773	1.000	1.000
236	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	19	ADCY1(5), AKT1(2), ASAH1(2), GNAI1(4), GNB1(1), ITGAV(4), ITGB3(3), MAPK1(4), MAPK3(2), PDGFA(1), PLCB1(4), PRKCA(6), PTK2(2), RAC1(1), SMPD1(2), SMPD2(1), SRC(2)	25548141	46	34	46	12	12	4	9	8	11	2	0.122	1.000	1.000
237	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	9	DFFA(2), GZMB(3), HMGB2(1), TOP2A(4), TOP2B(3)	10768918	13	8	13	6	5	1	2	3	2	0	0.798	1.000	1.000
238	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM1(1), CALM3(1), CAMK1(2), CAMK1G(1), CAMK2A(3), CAMK2D(1), CAMK2G(2), CAMK4(3), CAMKK1(2), CAMKK2(2), CREB1(2), SYT1(3)	13810907	23	14	23	8	6	5	5	1	6	0	0.384	1.000	1.000
239	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	8	CHUK(1), DNAJC3(2), EIF2S2(2), NFKB1(2), NFKBIA(3), RELA(1)	10713737	11	8	11	5	2	2	1	4	2	0	0.731	1.000	1.000
240	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(9), BST1(1), CD38(1), ENPP1(5), ENPP3(2), NADK(1), NADSYN1(5), NMNAT1(1), NMNAT3(1), NNMT(1), NNT(6), NT5C(3), NT5C1A(1), NT5C1B(7), NT5C2(1), NT5E(3), NT5M(1), NUDT12(1)	25653243	50	36	48	15	12	14	8	11	5	0	0.160	1.000	1.000
241	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(2), CAMK1G(1), HDAC9(3), MEF2A(4), MEF2B(1), MEF2D(1), MYOD1(1), YWHAH(2)	9283087	15	11	15	6	2	5	2	2	4	0	0.628	1.000	1.000
242	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(5), CD3D(1), CD3E(2), CD3G(1), CD4(2), CREBBP(13), CSK(2), GNAS(4), GNB1(1), HLA-DRA(4), HLA-DRB1(1), LCK(1), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), PTPRC(9), ZAP70(8)	27450911	59	45	59	13	21	9	4	16	9	0	0.0727	1.000	1.000
243	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(5), CD3D(1), CD3E(2), CD3G(1), CD4(2), CREBBP(13), CSK(2), GNAS(4), GNB1(1), HLA-DRA(4), HLA-DRB1(1), LCK(1), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), PTPRC(9), ZAP70(8)	27450911	59	45	59	13	21	9	4	16	9	0	0.0727	1.000	1.000
244	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6AP1(3), ATP6V0A4(3), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(1), ATP6V1G1(1), ATP6V1G3(2), ATP6V1H(1), FDXR(1), SHMT1(2)	19100328	25	20	25	7	8	7	4	5	0	1	0.210	1.000	1.000
245	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	CLOCK(3), CRY1(3), CSNK1E(1), PER1(6)	10181813	13	9	12	6	3	3	1	4	2	0	0.826	1.000	1.000
246	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(9), PRKACG(1), PRKAG1(1), PRKAR2B(1)	12025328	12	8	12	6	2	0	1	6	3	0	0.894	1.000	1.000
247	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(1), IARS(4), LARS(4), PDHA1(6), PDHA2(7), PDHB(1)	11943216	23	18	21	9	3	8	2	5	5	0	0.626	1.000	1.000
248	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(4), CAPN1(2), CAPNS1(2), CAPNS2(1), CSNK1A1(2), CSNK1D(2), GSK3B(1), PPP2CA(4)	11096175	18	10	18	7	4	3	4	6	1	0	0.621	1.000	1.000
249	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	BPNT1(1), CHST11(3), CHST13(3), SULT1A1(1), SULT1A2(1), SULT2A1(2), SULT2B1(3), SUOX(2)	10959918	16	12	16	6	3	2	0	8	3	0	0.691	1.000	1.000
250	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(1), ATP6V0C(1), CAT(3), EPX(7), LPO(5), MPO(4), PRDX1(1), SHMT1(2), TPO(10)	14096861	34	20	34	10	16	9	2	4	2	1	0.108	1.000	1.000
251	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CD36(5), FOS(2), FYN(2), THBS1(6)	8802223	15	12	15	7	5	5	3	1	1	0	0.529	1.000	1.000
252	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(3), EIF2AK4(4), EIF2S2(2), EIF2S3(3), GSK3B(1), PPP1CA(1)	13770141	14	12	14	8	1	2	4	4	3	0	0.898	1.000	1.000
253	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CCR5(1), CD2(1), CD3D(1), CD3E(2), CD3G(1), CD4(2), IFNG(2), IL12B(4), IL12RB1(4), IL12RB2(4), JAK2(5), STAT4(4), TYK2(10)	17573618	41	26	41	10	19	2	6	9	5	0	0.140	1.000	1.000
254	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(5), GNAS(4), GNB1(1), PPP2CA(4), PRKAA1(3), PRKAA2(2), PRKACG(1), PRKAG1(1), PRKAG2(2), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1)	18322150	27	18	27	6	11	2	0	10	4	0	0.297	1.000	1.000
255	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(3), ACTN2(6), BCAR1(3), CSK(2), CTNNA1(2), CTNNA2(5), CTNNB1(3), PTK2(2), PXN(1), SRC(2), VCL(1)	22865638	30	20	30	8	11	5	3	6	5	0	0.237	1.000	1.000
256	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CCR5(1), CD3D(1), CD3E(2), CD3G(1), ETV5(3), IFNG(2), IL12B(4), IL12RB1(4), IL12RB2(4), IL18(3), IL18R1(4), JAK2(5), MAPK8(2), STAT4(4), TYK2(10)	22279971	50	34	50	15	19	3	10	13	5	0	0.278	1.000	1.000
257	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(2), AGPAT2(2), AGPAT3(1), AGPAT6(2), AGPS(3), ENPP2(7), ENPP6(2), PAFAH1B1(4), PAFAH1B3(1), PAFAH2(2), PLA2G12B(1), PLA2G2D(1), PLA2G2F(1), PLA2G3(5), PLA2G4A(7), PLA2G5(1), PLA2G6(3), PLD1(8), PPAP2A(2), PPAP2C(1)	27633502	56	38	55	15	17	8	8	18	5	0	0.149	1.000	1.000
258	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	ALDOA(1), CTSD(1), ESR1(3), GREB1(7), MTA1(1), MTA3(3), PDZK1(1), TUBA8(2)	13060979	19	12	19	8	8	3	1	4	3	0	0.537	1.000	1.000
259	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(1), PSMA2(2), PSMA3(2), PSMA4(1), PSMA5(1), PSMB1(1), PSMB2(1), PSMB3(1), PSMB4(1), PSMB5(1), PSMB6(1), PSMC3(2), RPN1(1), RPN2(1), UBE3A(2)	15375295	19	11	19	6	4	5	4	3	3	0	0.503	1.000	1.000
260	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	18	B2M(1), HLA-A(1), IL18(3), ITGB1(3), KLRC1(3), KLRC2(1), KLRC3(4), KLRC4(1), KLRD1(1), LAT(2), MAP2K1(1), MAPK3(2), PAK1(3), PTK2B(5), PTPN6(1), RAC1(1), VAV1(9)	17707722	42	28	41	13	10	4	6	10	11	1	0.386	1.000	1.000
261	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	27	ELK1(5), GNAS(4), GNB1(1), IGF1R(10), ITGB1(3), MAP2K1(1), MAP2K2(1), MAPK1(4), MAPK3(2), MKNK1(2), NGFR(1), PPP2CA(4), PTPRR(6), RAF1(2), RPS6KA1(5), RPS6KA5(2), SHC1(1), SOS1(7), SRC(2), STAT3(3)	33680749	66	51	66	16	18	8	9	17	13	1	0.0896	1.000	1.000
262	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	ATF2(2), BCR(3), BLNK(2), ELK1(5), FOS(2), LYN(2), MAP2K1(1), MAP3K1(10), MAPK1(4), MAPK3(2), MAPK8IP3(7), PAPPA(6), RAC1(1), RPS6KA1(5), RPS6KA3(4), SHC1(1), SOS1(7), VAV1(9), VAV2(4), VAV3(3)	38254161	80	55	78	19	17	16	8	23	14	2	0.0305	1.000	1.000
263	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	CARM1(1), CBS(5), CTH(2), GGT1(3), LCMT1(3), LCMT2(2), MARS(7), MARS2(2), MAT1A(2), METTL2B(3), METTL6(2), PRMT2(2), PRMT5(4), PRMT6(1), PRMT7(1), PRMT8(5), SCLY(3), SEPHS1(1), WBSCR22(2)	29729436	51	30	51	11	10	11	8	13	9	0	0.0467	1.000	1.000
264	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	25	AKT1(2), CISH(1), IARS(4), IL13RA1(3), IL4R(10), INPP5D(5), JAK1(3), JAK2(5), JAK3(5), NR0B2(1), PI3(2), PPP1R13B(2), RPS6KB1(2), SERPINA4(2), SHC1(1), SOS1(7), SOS2(5), SRC(2), STAT6(5), TYK2(10)	41453800	77	57	77	11	24	7	8	24	14	0	0.00151	1.000	1.000
265	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	AKR1B10(3), DHRS2(2), DHRS3(1), DHRS7(1), DHRSX(1), HSD3B7(1), PON1(4), PON3(1)	10704829	14	10	13	9	6	0	1	5	2	0	0.961	1.000	1.000
266	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	GUSB(3), RPE(1), UCHL3(1), UGDH(1), UGT1A1(5), UGT1A10(2), UGT1A3(3), UGT1A4(1), UGT1A5(3), UGT1A6(4), UGT1A7(3), UGT1A9(2), UGT2B15(3), UGT2B4(10)	20955656	42	34	41	13	12	7	7	13	3	0	0.239	1.000	1.000
267	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(17), ACACB(18), FASN(3), MCAT(3), OXSM(3)	18891644	44	35	44	14	15	7	5	10	7	0	0.253	1.000	1.000
268	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	18	CSNK2A1(2), ELK1(5), FOS(2), INS(1), INSR(6), IRS1(8), MAP2K1(1), MAPK3(2), MAPK8(2), RAF1(2), RASA1(4), SHC1(1), SLC2A4(2), SOS1(7), SRF(3)	24459265	48	36	48	14	12	12	4	9	10	1	0.197	1.000	1.000
269	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(1), ALDH4A1(2), ALDH5A1(2), CAD(8), CPS1(8), EPRS(5), GAD1(3), GAD2(1), GCLC(1), GFPT1(5), GLS(4), GLS2(1), GLUD1(5), GLUL(2), GOT1(2), GOT2(1), GSS(2), NADSYN1(5), PPAT(2), QARS(5)	39509309	65	44	65	9	13	11	13	18	10	0	0.00220	1.000	1.000
270	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(9), BAIAP2(3), CASP1(7), CASP8(2), GAPDH(1), INS(1), INSR(6), ITCH(1), MAGI1(6), MAGI2(6), RERE(11), WWP1(3), WWP2(2)	28586626	58	40	57	16	16	14	5	16	7	0	0.205	1.000	1.000
271	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	6	EEA1(3), EGF(10), HGS(3), TF(2), TFRC(2)	12152883	20	15	20	9	6	3	2	7	2	0	0.781	1.000	1.000
272	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	EPHA4(8), EPHB1(4), FYN(2), ITGA1(4), ITGB1(3), L1CAM(12), LYN(2), SELP(4)	18805808	39	27	39	13	13	7	8	10	1	0	0.328	1.000	1.000
273	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(3), CALM1(1), CALM3(1), CRKL(2), MAP2K1(1), MAP2K2(1), MAP2K3(6), MAP3K1(10), MAPK1(4), MAPK3(2), MAPK8(2), PAK1(3), PLCG1(12), PRKCA(6), PTK2B(5), RAC1(1), RAF1(2), SHC1(1), SOS1(7), SRC(2), SYT1(3)	34003657	75	55	70	16	18	15	13	12	15	2	0.00840	1.000	1.000
274	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	14	AKT1(2), CDKN1A(2), ELK1(5), MAP2K1(1), MAP2K2(1), NGFR(1), NTRK1(3), PIK3CD(3), SHC1(1), SOS1(7)	16731636	26	19	26	9	6	4	2	7	7	0	0.438	1.000	1.000
275	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	23	ABL1(6), ATM(12), ATR(10), CCNA1(3), CCND1(4), CCNE1(2), CDC25A(1), CDK2(1), CDK4(1), CDK6(1), CDKN1A(2), CDKN1B(4), CDKN2A(6), CDKN2B(2), DHFR(1), E2F1(1), GSK3B(1), SKP2(3), TFDP1(1), TGFB2(2), TGFB3(1)	32843411	65	43	64	10	11	9	11	19	15	0	0.0110	1.000	1.000
276	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(3), ALOX15(2), ALOX5(3), CYP1A2(4), CYP2C18(4), CYP2C19(5), CYP2C8(4), CYP2C9(3), CYP2E1(2), CYP3A4(5), CYP3A43(1), CYP3A5(4), CYP3A7(3), HSD3B7(1), PLA2G12B(1), PLA2G2D(1), PLA2G2F(1), PLA2G3(5), PLA2G4A(7), PLA2G5(1), PLA2G6(3)	28440889	63	52	63	17	22	8	7	16	10	0	0.136	1.000	1.000
277	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	12	AGA(1), FUCA1(6), FUCA2(3), GLB1(2), HEXA(1), HEXB(1), LCT(13), MAN2C1(2), MANBA(1), NEU1(2), NEU3(2), NEU4(2)	18830277	36	28	36	11	10	6	6	10	4	0	0.367	1.000	1.000
278	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	11	AKT1(2), CHRNB1(2), CHRNG(3), MUSK(5), PTK2(2), PTK2B(5), RAPSN(1), SRC(2), TERT(6), YWHAH(2)	15001234	30	25	30	10	11	1	3	8	7	0	0.369	1.000	1.000
279	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	18	ABCB1(15), AKT1(2), ATM(12), BAX(1), CDKN1A(2), CPB2(1), CSNK1A1(2), CSNK1D(2), MAPK8(2), MDM2(5), NQO1(1)	23831508	45	34	44	13	11	5	5	14	10	0	0.432	1.000	1.000
280	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BAX(1), BCL2(2), CASP8(2), CYCS(2), MAP2K1(1), MAP3K1(10), MAPK1(4), MAPK3(2), MAPK8(2), NFKB1(2), NSMAF(3), RAF1(2), RELA(1), RIPK1(4), SMPD1(2), TNFRSF1A(1), TRADD(1), TRAF2(2)	24489565	44	35	42	13	11	10	7	5	10	1	0.211	1.000	1.000
281	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	15	AKT1(2), CREB1(2), MAPK1(4), MAPK3(2), MAPK7(6), MEF2A(4), MEF2B(1), MEF2D(1), NTRK1(3), PLCG1(12), RPS6KA1(5), SHC1(1)	18101526	43	33	41	13	7	9	5	10	11	1	0.275	1.000	1.000
282	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B10(3), B4GALT2(1), G6PC(8), G6PC2(1), GAA(6), GALK1(1), GALK2(1), GALT(1), GANC(5), GCK(2), GLA(2), GLB1(2), HK1(4), HK2(5), HK3(5), HSD3B7(1), LCT(13), MGAM(14), PFKL(6), PFKP(1), PGM1(1), PGM3(1), UGP2(1)	46093497	85	56	85	20	46	9	7	16	7	0	0.00750	1.000	1.000
283	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(5), CALM1(1), CALM3(1), CREB1(2), ELK1(5), FOS(2), GNAI1(4), GNAS(4), GNB1(1), MAP2K1(1), MAPK3(2), NFATC1(2), NFATC2(7), NFATC3(3), NFATC4(5), PLCG1(12), PPP3CA(1), PPP3CB(1), PPP3CC(1), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), PRKCA(6), RAF1(2), RPS6KA3(4), SYT1(3)	41732344	80	61	78	21	21	10	11	19	17	2	0.0803	1.000	1.000
284	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(3), AXIN1(4), BTRC(2), CCND1(4), CREBBP(13), CSNK1A1(2), CSNK1D(2), CSNK2A1(2), CTBP1(5), CTNNB1(3), DVL1(1), FZD1(3), GSK3B(1), MAP3K7(3), NLK(1), PPP2CA(4), WIF1(4), WNT1(1)	35060700	58	37	58	13	11	9	8	16	14	0	0.110	1.000	1.000
285	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	18	AKT1(2), EIF4A1(7), EIF4A2(2), EIF4B(3), EIF4E(2), EIF4G1(5), EIF4G2(1), EIF4G3(7), MKNK1(2), PPP2CA(4), RPS6KB1(2), TSC1(2), TSC2(6)	27479302	45	33	45	11	12	8	6	13	6	0	0.147	1.000	1.000
286	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	59	ATP12A(7), ATP4B(2), ATP6AP1(3), ATP6V0A4(3), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(1), ATP6V1G1(1), ATP6V1G3(2), ATP6V1H(1), ATP7A(13), ATP7B(4), COX10(5), COX6B1(1), COX7A1(1), COX7C(1), NDUFA10(4), NDUFA4(1), NDUFB5(1), NDUFS1(2), NDUFS2(1), NDUFV1(2), NDUFV2(1), PPA2(1), SDHA(4), SHMT1(2), UQCRC1(4), UQCRH(2)	45330345	81	55	80	15	17	15	14	25	9	1	0.00332	1.000	1.000
287	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	APAF1(3), BCL2(2), CASP9(1), CYCS(2), DAXX(5), FAS(1), FASLG(1), IL1A(1), MAPKAPK2(2), MAPKAPK3(2), TNF(1)	13518859	21	14	21	9	1	6	4	7	3	0	0.773	1.000	1.000
288	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ALDH1A1(2), ALDH1A2(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3B2(3), AOC2(1), ASPA(1), CNDP1(4), DDC(6), HAL(3), HARS(4), HDC(5), HNMT(1), MAOA(3), MAOB(2), PRPS1(1), PRPS2(5)	29140552	59	42	59	17	31	7	5	13	3	0	0.0936	1.000	1.000
289	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOA(1), ALDOB(2), DLD(3), ENO1(2), ENO2(2), ENO3(3), FBP1(3), FBP2(2), G6PC(8), GAPDH(1), GAPDHS(2), GCK(2), GOT1(2), GOT2(1), GPI(2), HK1(4), HK2(5), HK3(5), LDHA(1), LDHAL6B(2), LDHB(2), LDHC(1), PC(4), PCK1(6), PDHA1(6), PDHA2(7), PDHB(1), PFKL(6), PFKP(1), PGAM2(1), PGK1(3), PGK2(1), PKLR(3), TNFAIP1(3), TPI1(1)	50590083	99	71	97	24	40	24	4	20	11	0	0.00290	1.000	1.000
290	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	24	ADCY1(5), AKT1(2), CAMK2A(3), CAMK2D(1), CAMK2G(2), CREB1(2), GNAS(4), MAPK1(4), MAPK3(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), PRKCA(6), RAC1(1), RPS6KA1(5), RPS6KA5(2), SOS1(7)	30259658	51	38	51	11	20	4	6	8	11	2	0.0649	1.000	1.000
291	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(3), GLI2(7), GLI3(8), GSK3B(1), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), SHH(3), SMO(3), SUFU(4)	19908198	34	23	34	10	9	7	3	8	7	0	0.272	1.000	1.000
292	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	28	ATF1(1), CREB1(2), DUSP4(1), DUSP9(2), EEF2K(2), EIF4E(2), MAP2K1(1), MAP2K2(1), MAP3K8(4), MAPK1(4), MAPK3(2), MKNK1(2), NFKB1(2), RPS6KA1(5), RPS6KA2(6), RPS6KA3(4), SHC1(1), SOS1(7), SOS2(5), TRAF3(2)	33479973	56	35	56	15	16	5	7	17	10	1	0.208	1.000	1.000
293	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(3), ABAT(1), ADSL(4), AGXT(2), AGXT2(2), ASL(2), ASNS(5), ASPA(1), CAD(8), CRAT(2), DARS(1), GAD1(3), GAD2(1), GOT1(2), GOT2(1), NARS(2), PC(4)	31045427	44	26	44	9	9	10	4	13	8	0	0.0701	1.000	1.000
294	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(4), COL4A2(8), COL4A3(1), COL4A4(11), COL4A5(12), COL4A6(9), P4HB(1), SLC23A1(2), SLC23A2(3), SLC2A1(4), SLC2A3(6)	29968646	61	43	61	20	19	14	8	12	7	1	0.110	1.000	1.000
295	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS2(2), DHRS3(1), DHRS7(1), DHRSX(1), ESCO1(2), ESCO2(2), PNPLA3(1), SH3GLB1(3)	19751816	13	6	12	3	5	4	1	2	1	0	0.287	1.000	1.000
296	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GSS(2), NFKB1(2), NOX1(1), RELA(1), TNF(1), XDH(11)	11850132	18	11	18	9	5	5	0	7	1	0	0.747	1.000	1.000
297	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(4), AR(4), ESR1(3), ESR2(6), ESRRA(2), HNF4A(7), NPM1(3), NR0B1(1), NR1D1(1), NR1D2(1), NR1H2(4), NR1H3(5), NR1I2(2), NR1I3(1), NR2C2(3), NR2E1(2), NR2F1(1), NR2F2(5), NR3C1(3), NR4A1(3), NR4A2(1), NR5A1(1), NR5A2(2), PGR(9), PPARA(4), PPARG(3), RARB(2), ROR1(3), RORA(1), RORC(4), RXRA(4), RXRG(3), THRA(3), THRB(2), VDR(2)	50205631	105	73	102	27	41	15	14	25	10	0	0.0280	1.000	1.000
298	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ALDH1A3(5), ALDH3A1(6), ALDH3B2(3), AOC2(1), DDC(6), EPX(7), GOT1(2), GOT2(1), HPD(1), LPO(5), MAOA(3), MAOB(2), MPO(4), PRDX1(1), TAT(3), TPO(10)	26215636	60	43	59	18	31	9	5	10	4	1	0.0699	1.000	1.000
299	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(4), AP2A1(1), AP2M1(1), BIN1(2), CALM1(1), CALM3(1), DNM1(1), EPN1(1), EPS15(3), PICALM(3), PPP3CA(1), PPP3CB(1), PPP3CC(1), SYNJ1(6), SYNJ2(11), SYT1(3)	25755378	41	26	41	12	13	5	8	6	9	0	0.192	1.000	1.000
300	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	32	AGT(3), AGTR1(1), ATF2(2), CALM1(1), CALM3(1), ELK1(5), MAP2K1(1), MAP2K2(1), MAP3K1(10), MAPK1(4), MAPK3(2), MAPK8(2), MEF2A(4), MEF2B(1), MEF2D(1), PAK1(3), PRKCA(6), PTK2(2), PTK2B(5), RAC1(1), RAF1(2), SHC1(1), SOS1(7), SRC(2), SYT1(3)	36852060	71	49	68	16	13	15	11	13	17	2	0.0240	1.000	1.000
301	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	38	ATF2(2), CREB1(2), DAXX(5), DDIT3(3), ELK1(5), MAP3K1(10), MAP3K5(4), MAP3K7(3), MAP3K9(6), MAPKAPK2(2), MAPKAPK5(2), MEF2A(4), MEF2B(1), MEF2D(1), MKNK1(2), PLA2G4A(7), RAC1(1), RIPK1(4), RPS6KA5(2), SHC1(1), STAT1(4), TGFB2(2), TGFB3(1), TGFBR1(4), TRADD(1), TRAF2(2)	43055429	81	58	79	18	17	19	13	18	13	1	0.0235	1.000	1.000
302	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(4), DLG4(5), EPHB2(5), F2(4), F2RL1(4), F2RL3(3), MAP2K5(2), MAPK1(4), MAPK7(6), MAPK8(2), MYEF2(3), PLD1(8), PLD3(1), PTK2(2), RAF1(2), RASAL1(5), SRC(2), TEC(4), VAV1(9)	32765195	75	53	74	21	24	12	9	19	11	0	0.0917	1.000	1.000
303	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(1), ACACA(17), ACADL(1), ACADM(2), ACAT2(1), ALDH1A1(2), ALDH1A2(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH6A1(5), ECHS1(3), EHHADH(2), HADHA(3), LDHA(1), LDHB(2), LDHC(1), MLYCD(4), MUT(2), PCCA(3), PCCB(4), SDS(1), SUCLA2(1), SUCLG1(2), SUCLG2(1)	39435520	77	48	77	21	23	20	6	17	11	0	0.0981	1.000	1.000
304	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	40	CALM1(1), CALM3(1), CD3D(1), CD3E(2), CD3G(1), ELK1(5), FOS(2), FYN(2), LAT(2), LCK(1), MAP2K1(1), MAP3K1(10), MAPK3(2), MAPK8(2), NFATC1(2), NFATC2(7), NFATC3(3), NFATC4(5), NFKB1(2), NFKBIA(3), PLCG1(12), PPP3CA(1), PPP3CB(1), PPP3CC(1), PRKCA(6), PTPN7(2), RAC1(1), RAF1(2), RASA1(4), RELA(1), SHC1(1), SOS1(7), SYT1(3), VAV1(9), ZAP70(8)	52559604	114	76	110	26	31	20	15	28	18	2	0.00411	1.000	1.000
305	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ADCY1(5), CCNB1(2), GNAI1(4), GNAS(4), GNB1(1), MAPK1(4), MAPK3(2), MYT1(7), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), RPS6KA1(5), SRC(2)	24512869	41	36	41	11	12	2	5	7	14	1	0.318	1.000	1.000
306	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	35	BTK(4), CALM1(1), CALM3(1), ELK1(5), FCER1A(4), FOS(2), LYN(2), MAP2K1(1), MAP3K1(10), MAPK1(4), MAPK3(2), MAPK8(2), NFATC1(2), NFATC2(7), NFATC3(3), NFATC4(5), PAK2(2), PLA2G4A(7), PLCG1(12), PPP3CA(1), PPP3CB(1), PPP3CC(1), RAF1(2), SHC1(1), SOS1(7), SYT1(3), VAV1(9)	46852520	101	67	97	26	19	24	17	27	13	1	0.0204	1.000	1.000
307	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(1), ACAA1(1), ACAA2(3), ACADM(2), ACADS(5), ACAT2(1), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH6A1(5), ALDH7A1(2), AOX1(9), BCAT1(1), BCKDHA(1), BCKDHB(2), DBT(3), DLD(3), ECHS1(3), EHHADH(2), HADHA(3), HIBADH(1), HIBCH(2), HMGCS1(2), HMGCS2(3), HSD17B4(3), MCCC1(3), MCCC2(5), MUT(2), OXCT1(1), OXCT2(1), PCCA(3), PCCB(4)	51257463	93	59	89	22	32	21	9	16	15	0	0.0158	1.000	1.000
308	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(3), POLR2A(9), POLR2B(4), POLR2C(2), POLR2G(1), POLRMT(3)	16152682	22	17	22	8	6	3	3	7	3	0	0.618	1.000	1.000
309	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ACY3(1), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3B2(3), ALDH7A1(2), AMDHD1(2), AOC2(1), ASPA(1), CARM1(1), CNDP1(4), DDC(6), FTCD(4), HAL(3), HARS(4), HARS2(1), HDC(5), HNMT(1), LCMT1(3), LCMT2(2), MAOA(3), MAOB(2), METTL2B(3), METTL6(2), PRMT2(2), PRMT5(4), PRMT6(1), PRMT7(1), PRMT8(5), PRPS1(1), PRPS2(5), UROC1(2), WBSCR22(2)	47271592	93	61	93	26	41	10	10	22	10	0	0.0469	1.000	1.000
310	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	11	APC(3), AXIN1(4), BTRC(2), CTNNB1(3), DLL1(1), DVL1(1), FZD1(3), GSK3B(1), PSEN1(1), WNT1(1)	20710054	20	16	20	9	3	2	2	6	7	0	0.904	1.000	1.000
311	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(3), IL5(1), MAF(3), MAP2K3(6), NFATC1(2), NFATC2(7), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1)	14561228	27	19	27	11	12	1	3	6	5	0	0.423	1.000	1.000
312	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1R(5), DDX20(1), E2F1(1), E2F4(1), ETS1(6), ETV3(1), FOS(2), HDAC2(7), HDAC5(1), NCOR2(10), RBL1(6), RBL2(4), SIN3A(5), SIN3B(1)	31069749	51	32	50	15	10	7	6	14	14	0	0.369	1.000	1.000
313	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(1), ACPP(4), ACPT(2), ALPI(2), ALPP(7), ALPPL2(6), CYP19A1(3), CYP1A2(4), CYP2A13(2), CYP2A7(1), CYP2B6(6), CYP2C18(4), CYP2C19(5), CYP2C8(4), CYP2C9(3), CYP2D6(2), CYP2E1(2), CYP2F1(1), CYP3A4(5), CYP3A5(4), CYP3A7(3), CYP4B1(5), CYP51A1(2), PON1(4)	34848827	82	71	80	23	39	6	8	16	13	0	0.0928	1.000	1.000
314	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM1(1), CALM3(1), CHUK(1), EGR2(3), EGR3(2), MAP3K1(10), NFATC1(2), NFATC2(7), NFKB1(2), NFKBIA(3), PLCG1(12), PPP3CA(1), PPP3CB(1), PPP3CC(1), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), RELA(1), SYT1(3), VIP(2), VIPR2(2)	33369419	60	46	56	18	13	11	7	19	10	0	0.201	1.000	1.000
315	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	20	AKT1(2), BCL2(2), BCR(3), CRKL(2), FOS(2), JAK2(5), MAP2K1(1), MAP3K1(10), MAPK3(2), MAPK8(2), RAF1(2), SOS1(7), STAT1(4), STAT5A(1), STAT5B(2)	28984352	47	33	45	12	9	10	6	12	8	2	0.100	1.000	1.000
316	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(1), GPLD1(1), PGAP1(3), PIGA(3), PIGB(1), PIGC(1), PIGF(1), PIGG(2), PIGN(2), PIGO(5), PIGQ(3), PIGS(2), PIGT(1), PIGU(2), PIGW(2), PIGX(1), PIGZ(2)	28464189	33	15	33	9	12	3	6	7	5	0	0.244	1.000	1.000
317	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(1), IARS(4), IARS2(3), ILVBL(5), LARS(4), PDHA1(6), PDHA2(7), PDHB(1), VARS(4), VARS2(4)	22156996	39	27	37	11	7	10	4	12	6	0	0.297	1.000	1.000
318	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(3), CDH1(4), CREBBP(13), EP300(6), MAP2K1(1), MAP3K7(3), MAPK3(2), SKIL(3), TGFB2(2), TGFB3(1), TGFBR1(4), TGFBR2(5)	30585734	47	28	47	11	10	9	7	13	7	1	0.153	1.000	1.000
319	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	B4GALT2(1), FBP2(2), G6PC(8), GAA(6), GALK1(1), GALK2(1), GALT(1), GANAB(4), GCK(2), GLA(2), GLB1(2), HK1(4), HK2(5), HK3(5), LCT(13), MGAM(14), PFKP(1), PGM1(1), PGM3(1)	38842041	74	50	74	20	41	9	6	12	6	0	0.0328	1.000	1.000
320	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(3), AMT(3), ATIC(1), ATP6V0C(1), DHFR(1), GART(4), MTHFD1(3), MTHFD1L(1), MTHFR(7), MTHFS(2), MTR(2), SHMT1(2)	21324007	30	13	30	10	7	7	7	3	5	1	0.288	1.000	1.000
321	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	43	CBL(2), CD28(2), CD3D(1), CSK(2), CTLA4(1), DAG1(3), DTYMK(1), EPHB2(5), FBXW7(5), GRAP2(2), ITK(1), LAT(2), LCK(1), LCP2(1), MAPK1(4), NFAT5(4), NFKB1(2), NFKB2(3), NFKBIA(3), NFKBIE(3), PAK1(3), PAK2(2), PAK3(4), PAK4(3), PAK6(3), PAK7(5), PLCG1(12), PTPRC(9), RAF1(2), RASGRP1(2), RASGRP2(3), RASGRP3(2), RASGRP4(3), SOS1(7), SOS2(5), VAV1(9), ZAP70(8)	65657898	130	91	126	29	37	25	17	32	19	0	0.00648	1.000	1.000
322	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(1), ACADM(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH7A1(2), AOC2(1), CNDP1(4), DPYD(6), DPYS(5), ECHS1(3), EHHADH(2), GAD1(3), GAD2(1), HADHA(3), HIBCH(2), MLYCD(4), SMS(1), SRM(2)	32178413	58	33	57	18	19	10	4	16	9	0	0.202	1.000	1.000
323	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(4), AADAC(1), ABAT(1), ACADS(5), ACAT2(1), ACSM1(8), AKR1B10(3), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH5A1(2), ALDH7A1(2), BDH1(1), BDH2(1), ECHS1(3), EHHADH(2), GAD1(3), GAD2(1), HADHA(3), HMGCS1(2), HMGCS2(3), HSD17B4(3), HSD3B7(1), ILVBL(5), L2HGDH(1), OXCT1(1), OXCT2(1), PDHA1(6), PDHA2(7), PDHB(1), PLA1A(4), PPME1(1)	48358120	93	63	90	27	28	15	7	25	18	0	0.0833	1.000	1.000
324	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(1), MAPK8(2), NFKB1(2), RELA(1), TNFRSF13B(1), TNFRSF17(1), TNFSF13B(1), TRAF2(2), TRAF3(2), TRAF5(3), TRAF6(1)	17349337	17	12	17	9	7	4	2	2	2	0	0.785	1.000	1.000
325	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(4), ABAT(1), ACADS(5), ACAT2(1), ALDH1A1(2), ALDH1A2(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH5A1(2), ECHS1(3), EHHADH(2), GAD1(3), GAD2(1), HADHA(3), L2HGDH(1), OXCT1(1), PDHA1(6), PDHA2(7), PDHB(1), SDS(1)	30741208	62	46	59	21	21	13	4	11	13	0	0.164	1.000	1.000
326	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(3), AGTR2(4), CALM1(1), CALM3(1), CAMK2A(3), CAMK2D(1), CAMK2G(2), F2(4), FYN(2), GNA11(1), GNAI1(4), GNB1(1), JAK2(5), MAP2K1(1), MAP2K2(1), MAPK1(4), MAPK3(2), MAPK8(2), MYLK(7), PLCG1(12), PRKCA(6), PTK2B(5), RAF1(2), SHC1(1), SOS1(7), STAT1(4), STAT3(3), STAT5A(1), SYT1(3)	49714135	93	64	91	25	22	11	19	24	14	3	0.0526	1.000	1.000
327	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM1(1), CALM3(1), CAMK1(2), CAMK1G(1), CAMK2A(3), CAMK2D(1), CAMK2G(2), CAMK4(3), ESRRA(2), HDAC5(1), MEF2A(4), MEF2B(1), MEF2D(1), PPARA(4), PPP3CA(1), PPP3CB(1), PPP3CC(1), SLC2A4(2), SYT1(3), YWHAH(2)	24170187	37	21	37	11	8	9	6	5	9	0	0.214	1.000	1.000
328	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(4), ALG5(3), B4GALT2(1), DPAGT1(2), DPM1(3), FUT8(7), MAN1A1(3), MAN1B1(1), MGAT1(3), MGAT2(3), MGAT3(3), MGAT4A(1), MGAT5(2), RPN1(1), RPN2(1), ST6GAL1(2)	23691363	40	27	40	12	10	11	5	5	9	0	0.174	1.000	1.000
329	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(4), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH7A1(2), CYP2C19(5), CYP2C9(3), DHRS2(2), DHRS3(1), DHRS7(1), DHRSX(1), ECHS1(3), EHHADH(2), ESCO1(2), ESCO2(2), HADHA(3), PNPLA3(1), SH3GLB1(3), YOD1(1)	36840124	52	32	51	14	23	10	5	7	7	0	0.0891	1.000	1.000
330	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	26	ARHGDIB(1), CASP10(1), CASP8(2), CFLAR(1), DAXX(5), DFFA(2), FAF1(4), LMNA(2), LMNB2(3), MAP3K1(10), MAP3K7(3), MAPK8(2), PAK1(3), PAK2(2), PRKDC(14), PTPN13(4), RIPK2(1), SPTAN1(8)	46666417	68	46	65	13	13	19	11	15	9	1	0.0102	1.000	1.000
331	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(1), ALDH4A1(2), ALDH5A1(2), CAD(8), CPS1(8), EARS2(1), EPRS(5), GAD1(3), GAD2(1), GCLC(1), GFPT1(5), GFPT2(3), GLS(4), GLS2(1), GLUD1(5), GLUD2(4), GLUL(2), GNPNAT1(2), GOT1(2), GOT2(1), GSS(2), NADSYN1(5), PPAT(2), QARS(5)	47038423	75	51	75	16	15	13	14	21	12	0	0.0307	1.000	1.000
332	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	MRPL13(1), MRPS7(2), RPL10L(4), RPL11(2), RPL13A(2), RPL18A(1), RPL22L1(1), RPL24(1), RPL29(1), RPL32(1), RPL35(2), RPL36A(2), RPL37A(1), RPL3L(1), RPL6(1), RPL7(3), RPS11(1), RPS12(2), RPS18(2), RPS2(1), RPS21(1), RPS24(1), RPS3(3), RPS5(1)	26994890	38	25	37	9	13	2	4	9	10	0	0.479	1.000	1.000
333	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	7	ACO2(4), FH(1), OGDH(1), SDHA(4), SUCLA2(1)	10260215	11	9	10	8	4	1	4	1	1	0	0.907	1.000	1.000
334	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(2), BTK(4), CALM1(1), CALM3(1), CD79A(1), ELK1(5), FOS(2), LYN(2), MAP2K1(1), MAP3K1(10), MAPK3(2), MAPK8(2), NFATC1(2), NFATC2(7), NFATC3(3), NFATC4(5), PLCG1(12), PPP3CA(1), PPP3CB(1), PPP3CC(1), PRKCA(6), RAC1(1), RAF1(2), SHC1(1), SOS1(7), SYT1(3), VAV1(9)	45598873	94	61	90	27	21	20	13	23	15	2	0.0655	1.000	1.000
335	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(5), ADRBK2(7), ARRB2(2), CALM1(1), CALM3(1), CALML3(1), CALML6(1), CAMK2A(3), CAMK2D(1), CAMK2G(2), CLCA1(5), CLCA2(5), CLCA4(2), CNGA3(4), CNGA4(5), CNGB1(5), GNAL(1), GUCA1A(1), GUCA1C(1), PDC(3), PDE1C(9), PRKACG(1), PRKG1(2), PRKG2(6), PRKX(1)	36357071	75	51	75	23	32	12	4	15	12	0	0.123	1.000	1.000
336	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	31	CRKL(2), DOCK1(3), ELK1(5), FOS(2), HGF(4), ITGA1(4), ITGB1(3), MAP2K1(1), MAP2K2(1), MAP4K1(3), MAPK1(4), MAPK3(2), MAPK8(2), MET(13), PAK1(3), PTK2(2), PTK2B(5), PXN(1), RAF1(2), RASA1(4), SOS1(7), SRC(2), STAT3(3)	45684976	78	54	77	22	22	10	10	18	17	1	0.0964	1.000	1.000
337	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(17), ACACB(18), ACAT2(1), ACOT12(1), ACSS1(1), ACSS2(4), ACYP1(1), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH7A1(2), DLD(3), HAGH(1), LDHA(1), LDHAL6A(1), LDHAL6B(2), LDHB(2), LDHC(1), LDHD(1), ME1(2), ME2(2), ME3(1), PC(4), PCK1(6), PDHA1(6), PDHA2(7), PDHB(1), PKLR(3)	55753994	105	80	103	28	39	21	7	25	13	0	0.0315	1.000	1.000
338	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CD4(2), CSF2(2), HLA-DRA(4), HLA-DRB1(1), IFNB1(2), IFNG(2), IL10(1), IL12B(4), IL15(2), IL1A(1), IL3(2), IL5(1), IL6(2), IL7(1), PDGFA(1), TGFB2(2), TGFB3(1), TNF(1)	15809202	32	25	32	12	8	5	6	9	4	0	0.483	1.000	1.000
339	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(17), ACAT2(1), ACYP1(1), ADH5(1), ALDH1A1(2), ALDH1A2(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), DLD(3), HAGH(1), LDHA(1), LDHB(2), LDHC(1), LDHD(1), ME1(2), ME2(2), ME3(1), PC(4), PCK1(6), PDHA1(6), PDHA2(7), PDHB(1), PKLR(3)	44085368	81	61	79	23	28	19	5	18	11	0	0.0870	1.000	1.000
340	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(3), DARS(1), EPRS(5), FARS2(3), GARS(3), HARS(4), IARS(4), KARS(2), LARS(4), MARS(7), MARS2(2), NARS(2), QARS(5), RARS(3), SARS(1), TARS(1), WARS(1), WARS2(2), YARS(1)	38167169	54	35	54	12	9	13	6	18	8	0	0.168	1.000	1.000
341	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(6), ABCC2(1), ABCG2(3), BCHE(2), CES1(3), CES2(2), CYP3A4(5), CYP3A5(4), UGT1A1(5), UGT1A10(2), UGT1A3(3), UGT1A4(1), UGT1A5(3), UGT1A6(4), UGT1A7(3), UGT1A9(2)	27206592	49	39	48	17	17	4	10	11	7	0	0.283	1.000	1.000
342	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(3), ASNS(5), CA1(1), CA12(3), CA13(1), CA14(1), CA2(1), CA5A(2), CA9(1), CPS1(8), CTH(2), GLS(4), GLS2(1), GLUD1(5), GLUD2(4), GLUL(2), HAL(3)	25315862	47	35	47	15	14	9	3	13	8	0	0.335	1.000	1.000
343	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	25	ACLY(4), ACO1(6), ACO2(4), CLYBL(5), DLD(3), FH(1), IDH3A(1), IDH3B(1), OGDH(1), OGDHL(7), PC(4), PCK1(6), SDHA(4), SDHC(2), SUCLA2(1), SUCLG1(2), SUCLG2(1)	33589928	53	42	52	16	13	10	8	16	6	0	0.210	1.000	1.000
344	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	49	AGT(3), AKT1(2), CALM1(1), CALM3(1), CALR(2), CAMK1(2), CAMK1G(1), CAMK4(3), CREBBP(13), CSNK1A1(2), ELSPBP1(3), F2(4), GATA4(3), GSK3B(1), IGF1(3), MAP2K1(1), MAPK1(4), MAPK3(2), MAPK8(2), MYH2(25), NFATC1(2), NFATC2(7), NFATC3(3), NFATC4(5), NPPA(2), PPP3CA(1), PPP3CB(1), PPP3CC(1), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), RAF1(2), RPS6KB1(2), SYT1(3)	56083809	112	76	111	28	37	11	16	28	19	1	0.0119	1.000	1.000
345	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	ACVR1(3), APC(3), ATF2(2), AXIN1(4), BMP10(2), BMP2(1), BMP4(3), BMP5(8), BMPR1A(1), BMPR2(1), CHRD(2), CTNNB1(3), DVL1(1), FZD1(3), GATA4(3), GSK3B(1), MAP3K7(3), MYL2(2), NPPA(2), RFC1(2), TGFB2(2), TGFB3(1), TGFBR1(4), TGFBR2(5), TGFBR3(3), WNT1(1)	43439010	66	46	66	14	19	11	9	12	15	0	0.0399	1.000	1.000
346	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	19	AKT1(2), EIF4A1(7), EIF4A2(2), EIF4E(2), EIF4G1(5), EIF4G2(1), EIF4G3(7), GHR(4), IRS1(8), MAPK1(4), MAPK3(2), MKNK1(2), PABPC1(5), PRKCA(6), RPS6KB1(2)	28069790	59	40	59	17	16	10	9	11	11	2	0.249	1.000	1.000
347	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(3), AMT(3), ATIC(1), DHFR(1), FTCD(4), GART(4), MTFMT(1), MTHFD1(3), MTHFD1L(1), MTHFR(7), MTHFS(2), MTR(2), SHMT1(2)	22576189	34	17	34	12	9	7	7	4	6	1	0.360	1.000	1.000
348	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	41	AKT1(2), CAB39(2), EIF4B(3), FIGF(2), IGF1(3), INS(1), MAPK1(4), MAPK3(2), PGF(1), PIK3CB(7), PIK3CD(3), PIK3CG(12), PIK3R2(4), PIK3R3(2), PIK3R5(4), PRKAA1(3), PRKAA2(2), RICTOR(2), RPS6KA1(5), RPS6KA2(6), RPS6KA3(4), RPS6KA6(5), RPS6KB1(2), RPS6KB2(3), STK11(1), TSC1(2), TSC2(6), ULK1(2), ULK2(7), VEGFA(3), VEGFB(3), VEGFC(3)	57272429	111	75	110	29	32	15	17	30	16	1	0.0456	1.000	1.000
349	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	24	GUSB(3), RPE(1), UGDH(1), UGP2(1), UGT1A1(5), UGT1A10(2), UGT1A3(3), UGT1A4(1), UGT1A5(3), UGT1A6(4), UGT1A7(3), UGT1A9(2), UGT2A1(9), UGT2B10(4), UGT2B11(5), UGT2B15(3), UGT2B17(2), UGT2B28(8), UGT2B4(10), UGT2B7(4), XYLB(1)	31239073	75	59	73	25	21	8	13	28	5	0	0.398	1.000	1.000
350	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	32	AKT1(2), ASAH1(2), DAG1(3), DRD2(1), EPHB2(5), ITPR1(9), ITPR2(16), ITPR3(18), KCNJ3(2), KCNJ5(5), KCNJ9(1), MAPK1(4), PI3(2), PIK3CB(7), PITX2(7), PLCB1(4), PLCB2(7), PLCB3(4), PLCB4(4), RAF1(2), SHC1(1), SOS1(7), SOS2(5), SRC(2), STAT3(3), TERF2IP(1)	64953438	124	82	124	29	35	20	24	32	12	1	0.00472	1.000	1.000
351	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCL11(2), CCR3(2), CFL1(1), GNAS(4), GNB1(1), LIMK1(4), MAP2K1(1), MAPK1(4), MAPK3(2), MYL2(2), NOX1(1), PIK3C2G(10), PLCB1(4), PPP1R12B(1), PRKCA(6), PTK2(2), RAF1(2), ROCK2(5)	30041131	54	44	54	15	13	5	12	13	9	2	0.270	1.000	1.000
352	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	46	AKT1(2), BRD4(1), CBL(2), CDKN2A(6), FLOT1(1), FLOT2(3), GSK3B(1), INPPL1(8), IRS1(8), IRS2(1), IRS4(8), LNPEP(4), MAPK1(4), MAPK3(2), PARD3(3), PARD6A(1), PDK1(2), PIK3CD(3), PTPN1(1), RAF1(2), RPS6KA1(5), RPS6KA2(6), RPS6KA3(4), RPS6KB1(2), SFN(3), SHC1(1), SLC2A4(2), SORBS1(3), SOS1(7), SOS2(5), YWHAB(2), YWHAE(3), YWHAG(1), YWHAH(2), YWHAQ(1), YWHAZ(1)	65412621	111	75	110	26	19	14	18	34	25	1	0.0323	1.000	1.000
353	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(1), IFNB1(2), IKBKB(2), IL1A(1), IL1B(3), IL1R1(4), IL1RAP(2), IL1RN(2), IL6(2), IRAK1(3), IRAK2(3), IRAK3(9), MAP2K3(6), MAP3K1(10), MAP3K7(3), MAPK8(2), NFKB1(2), NFKBIA(3), RELA(1), TGFB2(2), TGFB3(1), TNF(1), TOLLIP(1), TRAF6(1)	35347053	67	50	65	20	16	17	9	15	10	0	0.121	1.000	1.000
354	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	23	GH1(2), GHR(4), INS(1), INSR(6), IRS1(8), JAK2(5), MAP2K1(1), MAPK1(4), MAPK3(2), PLCG1(12), PRKCA(6), PTPN6(1), RAF1(2), RPS6KA1(5), SHC1(1), SLC2A4(2), SOCS1(1), SOS1(7), SRF(3), STAT5A(1), STAT5B(2)	34935884	76	57	74	23	16	15	11	20	12	2	0.205	1.000	1.000
355	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	34	ANPEP(5), G6PD(3), GCLC(1), GGT1(3), GPX2(2), GPX5(1), GPX6(1), GSS(2), GSTA1(3), GSTA2(1), GSTA3(1), GSTA4(4), GSTA5(4), GSTK1(2), GSTM4(1), GSTM5(1), GSTT1(1), GSTZ1(3), OPLAH(3)	24290098	42	30	42	14	13	12	6	7	4	0	0.246	1.000	1.000
356	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	27	ARHGDIB(1), BAG4(1), CASP2(1), CASP8(2), CRADD(2), DFFA(2), LMNA(2), LMNB2(3), MADD(3), MAP3K1(10), MAP3K7(3), MAPK8(2), PAK1(3), PAK2(2), PRKDC(14), RIPK1(4), SPTAN1(8), TNF(1), TNFRSF1A(1), TRADD(1), TRAF2(2)	44272092	68	52	65	17	17	17	10	14	9	1	0.0580	1.000	1.000
357	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(5), CD2(1), CD33(6), CD5(2), CD7(3), CSF2(2), IFNB1(2), IFNG(2), IL10(1), IL12B(4), IL3(2), IL5(1), ITGAX(8), TLR2(5), TLR4(2), TLR7(10), TLR9(5)	22143496	61	51	60	23	22	5	7	20	7	0	0.531	1.000	1.000
358	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	24	AKT1(2), APC(3), AXIN1(4), CCND1(4), CD14(1), CTNNB1(3), DVL1(1), FZD1(3), GJA1(5), GNAI1(4), GSK3B(1), IRAK1(3), LBP(5), LEF1(1), LY96(2), NFKB1(2), PPP2CA(4), RELA(1), TLR4(2), TOLLIP(1), WNT1(1)	32211045	53	40	53	17	16	8	10	10	9	0	0.305	1.000	1.000
359	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ALDH1A3(5), ALDH3A1(6), ALDH3B2(3), AOC2(1), DDC(6), EPX(7), ESCO1(2), ESCO2(2), GOT1(2), GOT2(1), HPD(1), LPO(5), MAOA(3), MAOB(2), MPO(4), PNPLA3(1), SH3GLB1(3), TAT(3), TPO(10)	40806557	67	45	66	19	32	13	5	12	5	0	0.0604	1.000	1.000
360	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(11), CALM1(1), CALM3(1), CAPNS1(2), CAPNS2(1), EP300(6), HDAC2(7), MEF2D(1), NFATC1(2), NFATC2(7), PPP3CA(1), PPP3CB(1), PPP3CC(1), PRKCA(6), SYT1(3)	29043157	51	34	51	18	14	7	9	11	9	1	0.423	1.000	1.000
361	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AMD1(2), CBS(5), CTH(2), DNMT1(4), DNMT3A(12), DNMT3B(4), MARS(7), MARS2(2), MAT1A(2), MTFMT(1), MTR(2), SRM(2), TAT(3)	24699251	48	31	47	17	14	9	3	13	7	2	0.348	1.000	1.000
362	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	31	A1BG(2), AKT1(2), BTK(4), CDKN2A(6), GSK3B(1), IARS(4), INPP5D(5), PDK1(2), PPP1R13B(2), RPS6KA1(5), RPS6KA2(6), RPS6KA3(4), RPS6KB1(2), SFN(3), SHC1(1), SOS1(7), SOS2(5), TEC(4), YWHAB(2), YWHAE(3), YWHAG(1), YWHAH(2), YWHAQ(1), YWHAZ(1)	39295265	75	53	74	22	12	14	12	24	13	0	0.198	1.000	1.000
363	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	FOS(2), MAP2K1(1), MAPK1(4), MAPK3(2), NFKB1(2), NFKBIA(3), PLCB1(4), PRKCA(6), RAF1(2), RELA(1), TNF(1)	18494990	28	23	28	11	6	3	4	8	5	2	0.536	1.000	1.000
364	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(1), CREBBP(13), DUSP1(1), EP300(6), IKBKB(2), IL1B(3), MAP2K3(6), MAP3K7(3), NFKB1(2), NFKBIA(3), NR3C1(3), RELA(1), TGFBR1(4), TGFBR2(5), TLR2(5), TNF(1)	35385788	59	41	59	18	14	13	7	14	11	0	0.228	1.000	1.000
365	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	24	CPEB1(3), ERBB2(3), ERBB4(5), ETS1(6), ETV6(4), ETV7(1), FMN2(3), MAP2K1(1), MAPK1(4), MAPK3(2), NOTCH2(16), NOTCH3(7), NOTCH4(10), PIWIL1(2), PIWIL2(5), PIWIL3(5), PIWIL4(2), RAF1(2), SOS1(7), SOS2(5), SPIRE1(2), SPIRE2(3)	52065443	98	64	97	26	27	18	16	20	15	2	0.0907	1.000	1.000
366	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(3), AARS2(1), ABAT(1), ACY3(1), ADSL(4), ADSSL1(1), AGXT(2), AGXT2(2), ASL(2), ASNS(5), ASPA(1), ASS1(4), CAD(8), CRAT(2), DARS(1), DARS2(2), DLD(3), GAD1(3), GAD2(1), GOT1(2), GOT2(1), NARS(2), NARS2(1), PC(4), PDHA1(6), PDHA2(7), PDHB(1)	45101261	71	48	68	19	19	17	6	16	13	0	0.104	1.000	1.000
367	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT1(2), ANKRD6(4), APC(3), AXIN1(4), AXIN2(2), CSNK1A1(2), CTNNB1(3), DACT1(4), DKK1(2), DKK2(5), DKK4(2), DVL1(1), FSTL1(1), GSK3B(1), LRP1(29), MVP(3), NKD1(2), NKD2(4), PSEN1(1), PTPRA(7), SENP2(3), SFRP1(1), WIF1(4)	48166140	90	61	89	26	28	11	9	23	19	0	0.241	1.000	1.000
368	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(3), CAMK2D(1), CAMK2G(2), DAG1(3), ITPR1(9), ITPR2(16), ITPR3(18), NFAT5(4), PDE6A(4), PDE6B(5), PDE6C(7), SLC6A13(4), TF(2)	42785897	78	53	78	25	30	17	11	12	7	1	0.0703	1.000	1.000
369	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM1(1), CALM3(1), DLG4(5), GRIN1(2), GRIN2A(18), GRIN2B(10), GRIN2C(6), GRIN2D(5), NOS1(11), PPP3CA(1), PPP3CB(1), PPP3CC(1), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), PRKCA(6), SYT1(3)	30474968	76	63	76	28	37	9	9	13	7	1	0.238	1.000	1.000
370	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(3), ASAH1(2), CREB1(2), DAG1(3), EPHB2(5), FOS(2), MAPK1(4), MAPK10(1), MAPK8(2), MAPK8IP1(3), MAPK8IP2(4), MAPK8IP3(7), MAPK9(1)	34122707	39	31	39	12	9	7	11	5	7	0	0.234	1.000	1.000
371	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(7), AMY2B(6), ENPP1(5), ENPP3(2), G6PC(8), GAA(6), GANAB(4), GBE1(1), GCK(2), GPI(2), GUSB(3), GYS1(1), GYS2(2), HK1(4), HK2(5), HK3(5), MGAM(14), PGM1(1), PGM3(1), PYGB(3), PYGL(6), PYGM(2), SI(12), UCHL3(1), UGDH(1), UGT1A1(5), UGT1A10(2), UGT1A3(3), UGT1A4(1), UGT1A5(3), UGT1A6(4), UGT1A7(3), UGT1A9(2), UGT2B15(3), UGT2B4(10), UXS1(4)	67985445	144	98	143	32	56	23	16	32	17	0	0.00109	1.000	1.000
372	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTN1(3), ACTN2(6), CAPN1(2), CAPNS1(2), CAPNS2(1), ITGA1(4), ITGB1(3), ITGB3(3), PTK2(2), PXN(1), RAC1(1), SPTAN1(8), SRC(2), TLN1(5)	34006649	43	26	43	10	15	3	7	13	5	0	0.118	1.000	1.000
373	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(1), ALOX12(1), ALOX15(2), ALOX5(3), CBR1(2), CBR3(1), CYP4F2(3), CYP4F3(7), EPX(7), GGT1(3), LPO(5), LTA4H(4), MPO(4), PLA2G3(5), PLA2G4A(7), PLA2G5(1), PLA2G6(3), PRDX1(1), PTGES2(1), PTGIS(2), PTGS1(3), PTGS2(3), TBXAS1(3), TPO(10)	33252383	82	60	82	26	33	15	6	17	10	1	0.0986	1.000	1.000
374	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	35	ARSA(1), ARSD(3), ARSE(6), ASAH1(2), B4GALT6(2), DEGS1(2), DEGS2(2), ENPP7(4), GAL3ST1(2), GALC(1), GLA(2), GLB1(2), LCT(13), NEU1(2), NEU3(2), NEU4(2), PPAP2A(2), PPAP2C(1), SGMS2(3), SGPP1(1), SGPP2(3), SMPD1(2), SMPD2(1), SMPD3(2), SMPD4(1), SPTLC1(3), SPTLC2(2), UGCG(2), UGT8(2)	41785753	73	46	73	24	24	10	13	20	5	1	0.235	1.000	1.000
375	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	25	AKT1(2), BCL2(2), GSK3B(1), IL4R(10), IRS1(8), IRS2(1), JAK1(3), JAK3(5), MAP4K1(3), MAPK1(4), MAPK3(2), PDK1(2), PIK3CD(3), PPP1R13B(2), RAF1(2), SHC1(1), SOCS1(1), SOS1(7), SOS2(5), STAT6(5)	39079477	69	54	69	21	16	8	7	22	15	1	0.319	1.000	1.000
376	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	CBS(5), CTH(2), DNMT1(4), DNMT3A(12), DNMT3B(4), MARS(7), MARS2(2), MAT1A(2), MTR(2)	20750503	40	25	40	15	10	8	2	11	7	2	0.440	1.000	1.000
377	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(1), CREB1(2), CREBBP(13), EP300(6), NCOA3(5), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), RXRA(4)	24665228	36	27	36	13	10	6	2	9	9	0	0.612	1.000	1.000
378	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(1), AOC2(1), CES1(3), ESCO1(2), ESCO2(2), LIPA(2), PLA1A(4), PNPLA3(1), PPME1(1), SH3GLB1(3)	30226193	20	11	20	6	6	5	1	6	2	0	0.392	1.000	1.000
379	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2A1L(1), GTF2A2(1), GTF2E1(3), GTF2F1(1), GTF2H1(3), GTF2H4(2), GTF2IRD1(4), STON1(4), TAF1(12), TAF10(1), TAF1L(15), TAF2(6), TAF4(5), TAF4B(3), TAF5L(2), TAF6(2), TAF6L(1), TAF7(1), TAF7L(6), TAF9(2), TAF9B(1), TBPL1(1), TBPL2(2)	42977668	79	52	79	23	18	11	10	27	12	1	0.313	1.000	1.000
380	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	21	ATM(12), ATR(10), BRCA1(6), CCNB1(2), CDC25A(1), CDC25B(1), CDC34(2), CDKN1A(2), CHEK1(6), CHEK2(3), EP300(6), MDM2(5), MYT1(7), PRKDC(14), RPS6KA1(5), WEE1(2), YWHAH(2), YWHAQ(1)	49048283	87	61	87	24	20	13	11	22	20	1	0.296	1.000	1.000
381	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CHUK(1), CREBBP(13), EP300(6), HDAC3(1), IKBKB(2), NFKB1(2), NFKBIA(3), RELA(1), RIPK1(4), TNF(1), TNFRSF1A(1), TNFRSF1B(3), TRADD(1), TRAF6(1)	26695074	40	27	40	14	11	6	2	12	9	0	0.495	1.000	1.000
382	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(1), ACAA2(3), ACADL(1), ACADM(2), ACADS(5), ACAT2(1), ALDH1A1(2), ALDH1A2(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH6A1(5), AOX1(9), BCAT1(1), BCKDHA(1), BCKDHB(2), ECHS1(3), EHHADH(2), HADHA(3), HIBADH(1), MCCC1(3), MCCC2(5), MUT(2), OXCT1(1), PCCA(3), PCCB(4), SDS(1)	42891080	79	51	75	27	27	20	8	13	11	0	0.205	1.000	1.000
383	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	20	ARHGAP5(5), DIAPH1(5), FYN(2), GSN(2), ITGA1(4), ITGB1(3), MAP2K1(1), MAPK1(4), MAPK3(2), MYL2(2), MYLK(7), PTK2(2), PXN(1), RAF1(2), ROCK1(4), SHC1(1), SRC(2), TLN1(5)	40036433	54	36	53	16	14	2	11	16	10	1	0.270	1.000	1.000
384	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	18	ABL1(6), ATM(12), BRCA1(6), CDKN1A(2), CHEK1(6), CHEK2(3), MAPK8(2), MDM2(5), MRE11A(3), NFKB1(2), NFKBIA(3), RAD50(6), RBBP8(3), RELA(1)	34573517	60	40	60	18	16	10	9	16	9	0	0.424	1.000	1.000
385	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	30	DUSP1(1), MAPK1(4), MAPK10(1), MAPK12(2), MAPK13(2), MAPK3(2), MAPK8(2), MAPK8IP1(3), MAPK8IP2(4), MAPK8IP3(7), MAPK9(1), MAPKAPK5(2), NFKB1(2), NFKB2(3), NFKBIA(3), NFKBIE(3), PIK3CD(3), SYT1(3), TRAF2(2), TRAF3(2), TRAF5(3), TRAF6(1)	35600512	56	41	56	18	18	8	11	10	8	1	0.206	1.000	1.000
386	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	28	AKT1(2), CABIN1(11), CALM1(1), CALM3(1), CAMK1(2), CAMK1G(1), HDAC5(1), IGF1(3), IGF1R(10), INS(1), INSR(6), MAPK7(6), MEF2A(4), MEF2B(1), MEF2D(1), MYOD1(1), NFATC1(2), NFATC2(7), PPP3CA(1), PPP3CB(1), PPP3CC(1), SYT1(3), YWHAH(2)	37028831	69	48	69	25	19	10	12	16	12	0	0.310	1.000	1.000
387	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	36	ANKHD1(4), EEF1A2(1), EEF1B2(1), EEF1D(3), EEF2(2), EEF2K(2), EIF2AK1(1), EIF2AK2(1), EIF2AK3(3), EIF2B1(1), EIF2B4(1), EIF2S2(2), EIF2S3(3), EIF4A1(7), EIF4A2(2), EIF4E(2), EIF4G1(5), EIF4G3(7), EIF5A(1), EIF5B(1), ETF1(1), GSPT2(6), PABPC1(5), PABPC3(6), PAIP1(1), SLC35A4(1)	52036365	70	51	70	20	16	9	5	22	18	0	0.312	1.000	1.000
388	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(3), ADH1B(4), ADH6(3), ADH7(2), ADHFE1(2), AGPAT1(2), AGPAT2(2), AGPAT3(1), AKR1A1(3), ALDH1A1(2), ALDH1A2(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), CEL(4), DGAT1(2), DGKA(4), DGKB(3), DGKD(8), DGKE(3), DGKG(4), DGKH(4), DGKQ(3), DGKZ(3), GK(1), GLA(2), GLB1(2), LCT(13), LIPC(1), LIPF(1), LIPG(4), LPL(2), PNLIP(3), PNLIPRP1(4), PPAP2A(2), PPAP2C(1)	57475928	116	73	116	31	43	18	13	31	11	0	0.0183	1.000	1.000
389	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(2), AGPAT1(2), AGPAT2(2), AGPAT3(1), AGPS(3), CDS2(2), CHAT(6), CHKB(1), CLC(1), DGKA(4), DGKB(3), DGKD(8), DGKE(3), DGKG(4), DGKH(4), DGKQ(3), DGKZ(3), ETNK1(1), GNPAT(2), GPD2(2), LCAT(1), LGALS13(4), LYPLA1(1), LYPLA2(1), PAFAH1B1(4), PAFAH2(2), PCYT1A(2), PCYT1B(2), PISD(2), PLA2G3(5), PLA2G4A(7), PLA2G5(1), PLA2G6(3), PLCB2(7), PLCG1(12), PLCG2(12), PPAP2A(2), PPAP2C(1)	59584160	126	89	123	31	41	26	12	30	17	0	0.00691	1.000	1.000
390	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	40	APAF1(3), BAK1(2), BAX(1), BCL2(2), BIRC2(3), BIRC3(1), CASP2(1), CASP8(2), CASP9(1), CYCS(2), FAS(1), FASLG(1), GZMB(3), MAP3K1(10), MAPK10(1), MCL1(1), MDM2(5), NFKB1(2), NFKBIA(3), PARP1(3), PRF1(3), RELA(1), RIPK1(4), TNF(1), TNFRSF1A(1), TNFRSF1B(3), TNFSF10(2), TRADD(1), TRAF1(1), TRAF2(2)	43626144	67	57	65	23	18	12	9	17	11	0	0.385	1.000	1.000
391	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	186	ACTB(2), ACTG1(2), ACTN1(3), ACTN2(6), ACTN4(2), AKT1(2), ARHGAP5(5), BCAR1(3), BCL2(2), BIRC2(3), BIRC3(1), CAV3(1), CCND1(4), CCND2(2), CCND3(1), CHAD(1), COL11A1(8), COL11A2(11), COL1A1(4), COL1A2(20), COL2A1(7), COL3A1(9), COL4A1(4), COL4A2(8), COL4A4(11), COL4A6(9), COL5A1(7), COL5A2(4), COL5A3(2), COL6A1(7), COL6A2(6), COL6A3(28), COL6A6(8), COMP(1), CRKL(2), CTNNB1(3), DIAPH1(5), DOCK1(3), EGF(10), ELK1(5), ERBB2(3), FARP2(2), FIGF(2), FLNA(18), FLNB(12), FLNC(16), FLT1(10), FN1(9), FYN(2), GSK3B(1), HGF(4), IBSP(1), IGF1(3), IGF1R(10), ILK(1), ITGA1(4), ITGA10(5), ITGA11(3), ITGA2(5), ITGA2B(2), ITGA3(1), ITGA4(8), ITGA5(3), ITGA6(3), ITGA7(4), ITGA8(6), ITGA9(2), ITGAV(4), ITGB1(3), ITGB3(3), ITGB4(8), ITGB6(9), ITGB7(7), ITGB8(2), KDR(14), LAMA1(16), LAMA2(18), LAMA3(14), LAMA4(5), LAMA5(18), LAMB1(7), LAMB2(1), LAMB3(6), LAMB4(10), LAMC1(5), LAMC2(5), LAMC3(9), MAP2K1(1), MAPK1(4), MAPK10(1), MAPK3(2), MAPK8(2), MAPK9(1), MET(13), MYL2(2), MYL5(1), MYLK(7), MYLK2(1), PAK1(3), PAK2(2), PAK3(4), PAK4(3), PAK6(3), PAK7(5), PARVA(1), PARVB(3), PARVG(1), PDGFA(1), PDGFC(2), PDGFD(4), PDGFRB(4), PGF(1), PIK3CB(7), PIK3CD(3), PIK3CG(12), PIK3R2(4), PIK3R3(2), PIK3R5(4), PIP5K1C(2), PPP1CA(1), PPP1CB(1), PPP1CC(1), PPP1R12A(1), PRKCA(6), PRKCG(4), PTK2(2), PXN(1), RAC1(1), RAC2(1), RAF1(2), RAPGEF1(4), RELN(26), ROCK1(4), ROCK2(5), SHC1(1), SHC2(1), SHC3(1), SHC4(2), SOS1(7), SOS2(5), SPP1(2), SRC(2), THBS1(6), THBS2(6), THBS3(5), THBS4(5), TLN1(5), TLN2(9), TNC(9), TNN(7), TNR(5), TNXB(14), VASP(1), VAV1(9), VAV2(4), VAV3(3), VCL(1), VEGFA(3), VEGFB(3), VEGFC(3), VWF(14), ZYX(2)	429985338	827	390	819	290	261	154	99	191	116	6	0.00899	1.000	1.000
392	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	166	ADCY1(5), ADCY2(7), ADCY3(5), ADCY4(6), ADCY7(3), ADCY8(3), ADCY9(11), ADRA1A(2), ADRA1B(2), ADRB2(1), AGTR1(1), ATP2A1(3), ATP2A2(4), ATP2A3(4), ATP2B2(9), ATP2B3(8), AVPR1A(6), AVPR1B(2), BDKRB1(1), BST1(1), CACNA1A(5), CACNA1B(15), CACNA1C(7), CACNA1D(11), CACNA1E(12), CACNA1F(7), CACNA1G(7), CACNA1H(11), CACNA1I(9), CACNA1S(14), CALM1(1), CALM3(1), CALML3(1), CALML6(1), CAMK2A(3), CAMK2D(1), CAMK2G(2), CAMK4(3), CCKAR(1), CCKBR(2), CD38(1), CHRM1(3), CHRM2(3), CHRM3(4), CHRM5(4), CHRNA7(1), CYSLTR1(3), CYSLTR2(3), DRD1(1), EDNRA(1), EDNRB(1), ERBB2(3), ERBB3(4), ERBB4(5), F2R(2), GNA11(1), GNA14(3), GNA15(1), GNAL(1), GNAS(4), GRIN1(2), GRIN2A(18), GRIN2C(6), GRIN2D(5), GRM1(6), GRM5(6), GRPR(4), HRH1(3), HRH2(3), HTR2A(2), HTR2B(2), HTR2C(4), HTR4(2), HTR5A(8), HTR6(1), HTR7(4), ITPR1(9), ITPR2(16), ITPR3(18), LHCGR(2), LTB4R2(1), MYLK(7), MYLK2(1), NOS1(11), NOS3(10), NTSR1(4), P2RX1(2), P2RX2(2), P2RX3(1), P2RX4(1), P2RX5(2), P2RX7(1), PDE1A(3), PDE1B(2), PDE1C(9), PDGFRB(4), PHKA1(5), PHKA2(5), PHKB(1), PHKG1(3), PLCB1(4), PLCB2(7), PLCB3(4), PLCB4(4), PLCD1(4), PLCD3(2), PLCE1(10), PLCG1(12), PLCG2(12), PLCZ1(6), PPID(2), PPP3CA(1), PPP3CB(1), PPP3CC(1), PRKACG(1), PRKCA(6), PRKCG(4), PRKX(1), PTAFR(2), PTGER3(2), PTGFR(7), PTK2B(5), RYR1(16), RYR2(58), RYR3(29), SLC25A4(1), SLC25A5(4), SLC25A6(1), SLC8A1(3), SLC8A2(3), SLC8A3(2), TACR2(2), TACR3(7), TBXA2R(1), TNNC1(1), TNNC2(1), TRHR(2), TRPC1(2), VDAC1(1), VDAC2(2), VDAC3(3)	316036034	680	363	673	241	283	101	73	132	88	3	0.00912	1.000	1.000
393	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	135	ACTB(2), ACTG1(2), CHAD(1), COL11A1(8), COL11A2(11), COL17A1(5), COL1A1(4), COL1A2(20), COL2A1(7), COL3A1(9), COL4A1(4), COL4A2(8), COL4A4(11), COL4A6(9), COL5A1(7), COL5A2(4), COL5A3(2), COL6A1(7), COL6A2(6), COL6A3(28), COL6A6(8), COMP(1), DES(3), DSC1(6), DSC2(5), DSC3(9), DSG1(8), DSG2(8), DSG3(11), DSG4(7), FN1(9), GJA1(5), GJA10(2), GJA3(1), GJA4(1), GJA8(1), GJA9(1), GJB2(1), GJB3(2), GJB4(2), GJB6(2), GJC1(1), GJC3(2), GJD2(3), GJD4(1), IBSP(1), INA(1), ITGA6(3), ITGB4(8), KRT1(4), KRT12(3), KRT13(6), KRT14(2), KRT16(5), KRT17(3), KRT18(3), KRT19(3), KRT2(3), KRT20(5), KRT23(2), KRT24(3), KRT25(5), KRT27(2), KRT28(6), KRT3(4), KRT31(4), KRT32(1), KRT33A(7), KRT33B(3), KRT34(4), KRT35(4), KRT36(5), KRT37(7), KRT38(1), KRT39(4), KRT4(2), KRT40(3), KRT5(4), KRT6A(2), KRT6B(5), KRT6C(3), KRT7(1), KRT71(4), KRT73(5), KRT74(1), KRT75(6), KRT76(2), KRT77(1), KRT78(3), KRT79(6), KRT8(5), KRT81(4), KRT82(2), KRT83(4), KRT84(5), KRT86(4), KRT9(4), LAMA1(16), LAMA2(18), LAMA3(14), LAMA4(5), LAMA5(18), LAMB1(7), LAMB2(1), LAMB3(6), LAMB4(10), LAMC1(5), LAMC2(5), LAMC3(9), LMNA(2), LMNB2(3), NES(3), PRPH(1), RELN(26), SPP1(2), THBS1(6), THBS2(6), THBS3(5), THBS4(5), TNC(9), TNN(7), TNR(5), TNXB(14), VIM(3), VWF(14)	296091206	668	352	661	261	255	143	58	139	71	2	0.133	1.000	1.000
394	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	229	ADCYAP1R1(5), ADORA3(2), ADRA1A(2), ADRA1B(2), ADRA2A(1), ADRA2B(2), ADRA2C(3), ADRB2(1), AGTR1(1), AGTR2(4), AVPR1A(6), AVPR1B(2), AVPR2(4), BDKRB1(1), BRS3(1), C3AR1(3), C5AR1(4), CALCRL(1), CCKAR(1), CCKBR(2), CGA(1), CHRM1(3), CHRM2(3), CHRM3(4), CHRM4(3), CHRM5(4), CNR1(1), CNR2(3), CRHR2(5), CTSG(5), CYSLTR1(3), CYSLTR2(3), DRD1(1), DRD2(1), DRD3(3), DRD5(10), EDNRA(1), EDNRB(1), F2(4), F2R(2), F2RL1(4), F2RL3(3), FPR1(1), FSHR(3), GABBR1(2), GABBR2(2), GABRA2(3), GABRA3(4), GABRA4(10), GABRA5(4), GABRB1(6), GABRB3(7), GABRD(5), GABRE(5), GABRG1(7), GABRG2(6), GABRG3(2), GABRP(4), GABRQ(2), GABRR1(3), GABRR2(1), GALR1(2), GH1(2), GH2(2), GHR(4), GHRHR(3), GHSR(2), GIPR(2), GLP1R(2), GLP2R(3), GLRA1(2), GLRA2(2), GLRA3(3), GLRB(4), GNRHR(3), GPR156(2), GPR35(2), GPR50(4), GPR63(1), GPR83(4), GRIA1(7), GRIA2(2), GRIA3(9), GRIA4(4), GRID1(3), GRID2(5), GRIK1(6), GRIK2(4), GRIK3(6), GRIK4(5), GRIK5(3), GRIN1(2), GRIN2A(18), GRIN2B(10), GRIN2C(6), GRIN2D(5), GRIN3A(5), GRIN3B(2), GRM1(6), GRM2(4), GRM3(16), GRM4(6), GRM5(6), GRM6(6), GRM7(5), GRM8(7), GRPR(4), GZMA(1), HCRTR1(1), HCRTR2(3), HRH1(3), HRH2(3), HRH3(3), HRH4(2), HTR1A(2), HTR1B(3), HTR1D(3), HTR1E(3), HTR1F(3), HTR2A(2), HTR2B(2), HTR2C(4), HTR4(2), HTR5A(8), HTR6(1), HTR7(4), LEPR(3), LHCGR(2), LTB4R(1), LTB4R2(1), MC1R(3), MC2R(2), MC3R(6), MC4R(6), MC5R(5), MCHR1(2), MCHR2(3), MLNR(1), MTNR1A(2), MTNR1B(2), NMBR(6), NMUR1(4), NMUR2(6), NPBWR1(2), NPBWR2(4), NPFFR2(2), NPY1R(3), NPY2R(2), NPY5R(3), NR3C1(3), NTSR1(4), OPRD1(2), OPRL1(3), OPRM1(4), P2RX1(2), P2RX2(2), P2RX3(1), P2RX4(1), P2RX5(2), P2RX7(1), P2RY1(1), P2RY10(1), P2RY13(1), P2RY2(3), P2RY4(2), P2RY6(2), P2RY8(6), PARD3(3), PRL(1), PRLHR(1), PRLR(2), PRSS1(2), PRSS3(2), PTAFR(2), PTGER3(2), PTGER4(2), PTGFR(7), PTH2R(3), RXFP1(5), RXFP2(6), SCTR(1), SSTR2(4), SSTR3(6), SSTR5(1), TAAR1(2), TAAR2(2), TAAR5(1), TAAR6(1), TAAR8(1), TACR2(2), TACR3(7), TBXA2R(1), THRA(3), THRB(2), TRHR(2), TRPV1(4), TSHR(5), UTS2R(2), VIPR1(1), VIPR2(2)	258013448	657	343	648	250	282	101	66	150	58	0	0.0203	1.000	1.000
395	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	239	ACVR1B(4), ACVR1C(3), AKT1(2), ARRB1(2), ARRB2(2), ATF2(2), ATF4(1), BDNF(1), CACNA1A(5), CACNA1B(15), CACNA1C(7), CACNA1D(11), CACNA1E(12), CACNA1F(7), CACNA1G(7), CACNA1H(11), CACNA1I(9), CACNA1S(14), CACNA2D1(13), CACNA2D2(4), CACNA2D3(4), CACNA2D4(3), CACNB2(3), CACNB3(4), CACNB4(2), CACNG1(2), CACNG2(2), CACNG3(8), CACNG7(3), CACNG8(1), CD14(1), CDC25B(1), CHUK(1), CRKL(2), DAXX(5), DDIT3(3), DUSP1(1), DUSP10(2), DUSP14(1), DUSP16(3), DUSP4(1), DUSP5(4), DUSP7(1), DUSP9(2), ECSIT(1), EGF(10), ELK1(5), ELK4(2), FAS(1), FASLG(1), FGF13(3), FGF14(3), FGF16(2), FGF18(2), FGF23(1), FGF4(1), FGF5(3), FGF6(1), FGF7(2), FGFR1(3), FGFR2(4), FGFR3(5), FGFR4(5), FLNA(18), FLNB(12), FLNC(16), FOS(2), GADD45B(1), GNG12(1), IKBKB(2), IL1A(1), IL1B(3), IL1R1(4), IL1R2(3), MAP2K1(1), MAP2K2(1), MAP2K3(6), MAP2K5(2), MAP3K1(10), MAP3K10(1), MAP3K12(6), MAP3K13(4), MAP3K3(2), MAP3K4(7), MAP3K5(4), MAP3K6(1), MAP3K7(3), MAP3K8(4), MAP4K1(3), MAP4K2(1), MAP4K3(5), MAP4K4(4), MAPK1(4), MAPK10(1), MAPK12(2), MAPK13(2), MAPK3(2), MAPK7(6), MAPK8(2), MAPK8IP1(3), MAPK8IP2(4), MAPK8IP3(7), MAPK9(1), MAPKAPK2(2), MAPKAPK3(2), MAPKAPK5(2), MKNK1(2), MRAS(1), NFATC2(7), NFATC4(5), NFKB1(2), NFKB2(3), NLK(1), NR4A1(3), NTF3(2), NTRK1(3), PAK1(3), PAK2(2), PDGFA(1), PDGFRB(4), PLA2G12B(1), PLA2G2D(1), PLA2G2F(1), PLA2G3(5), PLA2G4A(7), PLA2G5(1), PLA2G6(3), PPM1A(1), PPM1B(3), PPP3CA(1), PPP3CB(1), PPP3CC(1), PRKACG(1), PRKCA(6), PRKCG(4), PRKX(1), PTPN5(1), PTPN7(2), PTPRR(6), RAC1(1), RAC2(1), RAF1(2), RAPGEF2(5), RASA1(4), RASA2(3), RASGRF1(7), RASGRF2(6), RASGRP1(2), RASGRP2(3), RASGRP3(2), RASGRP4(3), RPS6KA1(5), RPS6KA2(6), RPS6KA3(4), RPS6KA5(2), RPS6KA6(5), RRAS(1), SOS1(7), SOS2(5), SRF(3), STK3(3), STMN1(1), TAOK1(3), TAOK2(5), TAOK3(2), TGFB2(2), TGFB3(1), TGFBR1(4), TGFBR2(5), TNF(1), TNFRSF1A(1), TRAF2(2), TRAF6(1), ZAK(5)	324658078	614	320	603	222	202	103	73	127	105	4	0.0958	1.000	1.000
396	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	196	ABI2(3), ACTN1(3), ACTN2(6), ACTN4(2), APC(3), APC2(3), ARAF(1), ARHGEF1(1), ARHGEF12(4), ARHGEF4(4), ARHGEF6(7), ARHGEF7(2), ARPC1A(1), ARPC1B(2), ARPC2(1), ARPC3(1), ARPC4(1), BAIAP2(3), BCAR1(3), BDKRB1(1), CD14(1), CFL1(1), CFL2(2), CHRM1(3), CHRM2(3), CHRM3(4), CHRM4(3), CHRM5(4), CRKL(2), CSK(2), CYFIP2(4), DIAPH1(5), DIAPH2(5), DIAPH3(4), DOCK1(3), EGF(10), EZR(4), F2(4), F2R(2), FGD1(1), FGD3(4), FGF13(3), FGF14(3), FGF16(2), FGF18(2), FGF23(1), FGF4(1), FGF5(3), FGF6(1), FGF7(2), FGFR1(3), FGFR2(4), FGFR3(5), FGFR4(5), FN1(9), GIT1(2), GNA13(2), GNG12(1), GSN(2), INS(1), IQGAP1(9), IQGAP2(6), IQGAP3(4), ITGA1(4), ITGA10(5), ITGA11(3), ITGA2(5), ITGA2B(2), ITGA3(1), ITGA4(8), ITGA5(3), ITGA6(3), ITGA7(4), ITGA8(6), ITGA9(2), ITGAD(6), ITGAE(7), ITGAL(2), ITGAM(7), ITGAV(4), ITGAX(8), ITGB1(3), ITGB2(5), ITGB3(3), ITGB4(8), ITGB6(9), ITGB7(7), ITGB8(2), LIMK1(4), MAP2K1(1), MAP2K2(1), MAPK1(4), MAPK3(2), MRAS(1), MSN(2), MYH10(8), MYH14(7), MYH9(3), MYL2(2), MYL5(1), MYLK(7), MYLK2(1), NCKAP1(5), NCKAP1L(4), PAK1(3), PAK2(2), PAK3(4), PAK4(3), PAK6(3), PAK7(5), PDGFA(1), PDGFRB(4), PFN4(1), PIK3CB(7), PIK3CD(3), PIK3CG(12), PIK3R2(4), PIK3R3(2), PIK3R5(4), PIP4K2A(1), PIP4K2B(1), PIP4K2C(5), PIP5K1B(3), PIP5K1C(2), PPP1CA(1), PPP1CB(1), PPP1CC(1), PPP1R12A(1), PPP1R12B(1), PTK2(2), PXN(1), RAC1(1), RAC2(1), RAF1(2), RDX(5), ROCK1(4), ROCK2(5), RRAS(1), SCIN(2), SOS1(7), SOS2(5), SSH1(4), SSH2(2), SSH3(2), TIAM1(5), TIAM2(14), VAV1(9), VAV2(4), VAV3(3), VCL(1), WAS(3), WASF1(1), WASF2(1), WASL(2)	316897183	526	288	522	201	161	76	67	139	80	3	0.453	1.000	1.000
397	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(3), CD36(5), CD44(6), CHAD(1), COL11A1(8), COL11A2(11), COL1A1(4), COL1A2(20), COL2A1(7), COL3A1(9), COL4A1(4), COL4A2(8), COL4A4(11), COL4A6(9), COL5A1(7), COL5A2(4), COL5A3(2), COL6A1(7), COL6A2(6), COL6A3(28), COL6A6(8), DAG1(3), FN1(9), FNDC1(7), FNDC3A(5), FNDC4(1), FNDC5(1), GP5(2), GP9(1), HMMR(1), HSPG2(25), IBSP(1), ITGA1(4), ITGA10(5), ITGA11(3), ITGA2(5), ITGA2B(2), ITGA3(1), ITGA4(8), ITGA5(3), ITGA6(3), ITGA7(4), ITGA8(6), ITGA9(2), ITGAV(4), ITGB1(3), ITGB3(3), ITGB4(8), ITGB6(9), ITGB7(7), ITGB8(2), LAMA1(16), LAMA2(18), LAMA3(14), LAMA4(5), LAMA5(18), LAMB1(7), LAMB2(1), LAMB3(6), LAMB4(10), LAMC1(5), LAMC2(5), LAMC3(9), RELN(26), SDC1(2), SDC2(1), SDC3(1), SDC4(1), SPP1(2), SV2A(2), SV2B(5), SV2C(4), THBS1(6), THBS2(6), THBS3(5), THBS4(5), TNC(9), TNN(7), TNR(5), TNXB(14), VWF(14)	267513980	535	286	533	188	178	123	57	108	67	2	0.0162	1.000	1.000
398	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(5), ADCY2(7), ADCY3(5), ADCY4(6), ADCY5(8), ADCY6(2), ADCY7(3), ADCY8(3), ADCY9(11), ADRA1A(2), ADRA1B(2), ADRB2(1), ANXA6(3), ARRB1(2), ARRB2(2), ATP1A4(2), ATP1B1(1), ATP1B2(1), ATP2A2(4), ATP2A3(4), ATP2B2(9), ATP2B3(8), CACNA1A(5), CACNA1B(15), CACNA1C(7), CACNA1D(11), CACNA1E(12), CACNA1S(14), CACNB3(4), CALM1(1), CALM3(1), CALR(2), CAMK1(2), CAMK2A(3), CAMK2D(1), CAMK2G(2), CAMK4(3), CASQ1(2), CASQ2(3), CHRM1(3), CHRM2(3), CHRM3(4), CHRM4(3), CHRM5(4), GJA1(5), GJA4(1), GJB2(1), GJB3(2), GJB4(2), GJB6(2), GNA11(1), GNAI2(1), GNAI3(2), GNAO1(2), GNAZ(1), GNB1(1), GNB2(2), GNB3(1), GNB4(1), GNB5(1), GNG12(1), GNG2(1), GNG5(1), GRK4(5), GRK5(4), ITPR1(9), ITPR2(16), ITPR3(18), KCNB1(5), KCNJ3(2), KCNJ5(5), MIB1(5), MYCBP(1), NME7(2), PEA15(1), PLCB3(4), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), PRKCA(6), PRKCD(3), PRKCE(1), PRKCG(4), PRKCH(3), PRKCQ(4), PRKD1(1), RGS1(1), RGS11(1), RGS14(2), RGS18(2), RGS19(1), RGS3(11), RGS4(4), RGS6(3), RGS7(3), RGS9(5), RYR1(16), RYR2(58), RYR3(29), SFN(3), SLC8A1(3), SLC8A3(2), USP5(1), YWHAB(2), YWHAH(2), YWHAQ(1)	224106882	478	271	473	162	185	76	59	87	68	3	0.0129	1.000	1.000
399	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	247	ACVR1(3), ACVR1B(4), ACVR2A(2), AMHR2(2), BMP2(1), BMPR1A(1), BMPR1B(1), BMPR2(1), CCL1(1), CCL11(2), CCL13(1), CCL14(2), CCL16(1), CCL19(1), CCL2(1), CCL20(2), CCL24(2), CCL26(2), CCL27(1), CCL3(1), CCL5(1), CCR1(1), CCR2(2), CCR3(2), CCR4(3), CCR5(1), CCR6(3), CCR7(1), CCR8(3), CCR9(2), CD40(1), CD40LG(2), CD70(2), CLCF1(1), CNTF(1), CNTFR(2), CRLF2(3), CSF1R(5), CSF2(2), CSF2RA(9), CSF2RB(6), CSF3R(3), CX3CL1(2), CX3CR1(3), CXCL1(1), CXCL13(1), CXCL6(1), CXCL9(1), CXCR4(2), CXCR6(1), EDA(2), EDAR(7), EGF(10), EPO(2), EPOR(1), FAS(1), FASLG(1), FLT1(10), FLT3(8), FLT4(8), GDF5(2), GH1(2), GH2(2), GHR(4), HGF(4), IFNA10(2), IFNA5(1), IFNA6(1), IFNA7(1), IFNA8(1), IFNAR1(2), IFNAR2(2), IFNB1(2), IFNG(2), IFNGR1(1), IFNGR2(4), IFNK(1), IFNW1(3), IL10(1), IL10RB(1), IL12B(4), IL12RB1(4), IL12RB2(4), IL13RA1(3), IL15(2), IL15RA(1), IL17A(1), IL17B(1), IL17RA(3), IL17RB(2), IL18(3), IL18R1(4), IL18RAP(10), IL19(1), IL1A(1), IL1B(3), IL1R1(4), IL1R2(3), IL1RAP(2), IL20(1), IL20RA(2), IL21R(3), IL22(2), IL22RA1(1), IL23A(1), IL23R(5), IL26(3), IL2RB(2), IL3(2), IL3RA(4), IL4R(10), IL5(1), IL5RA(3), IL6(2), IL6R(1), IL6ST(3), IL7(1), IL7R(4), IL9(1), IL9R(2), INHBA(2), INHBB(1), INHBE(3), KDR(14), KIT(9), KITLG(3), LEPR(3), LIFR(2), LTB(1), LTBR(3), MET(13), MPL(5), NGFR(1), OSM(1), OSMR(5), PDGFC(2), PDGFRB(4), PLEKHO2(1), PPBP(2), PRL(1), PRLR(2), RELT(4), TGFB2(2), TGFB3(1), TGFBR1(4), TGFBR2(5), TNF(1), TNFRSF10C(1), TNFRSF10D(1), TNFRSF11A(5), TNFRSF11B(2), TNFRSF13B(1), TNFRSF14(1), TNFRSF17(1), TNFRSF1A(1), TNFRSF1B(3), TNFRSF21(2), TNFRSF25(2), TNFRSF4(3), TNFRSF6B(1), TNFRSF8(4), TNFRSF9(4), TNFSF10(2), TNFSF11(1), TNFSF13B(1), TNFSF14(7), TNFSF15(3), TNFSF18(1), TNFSF8(3), TNFSF9(5), TPO(10), VEGFA(3), VEGFB(3), VEGFC(3), XCL1(3), XCR1(1)	204244676	472	269	466	184	144	79	61	118	70	0	0.297	1.000	1.000
400	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	123	ABL1(6), ABLIM1(4), ABLIM2(2), ABLIM3(9), ARHGEF12(4), CFL1(1), CFL2(2), CXCR4(2), DCC(12), DPYSL5(3), EFNA1(1), EFNA3(4), EFNA5(3), EFNB1(3), EFNB2(2), EFNB3(2), EPHA1(4), EPHA2(2), EPHA3(10), EPHA4(8), EPHA5(9), EPHA6(6), EPHA7(8), EPHA8(9), EPHB1(4), EPHB2(5), EPHB3(1), EPHB4(6), EPHB6(10), FES(6), FYN(2), GNAI1(4), GNAI2(1), GNAI3(2), GSK3B(1), ITGB1(3), L1CAM(12), LIMK1(4), LRRC4C(6), MAPK1(4), MAPK3(2), MET(13), NFAT5(4), NFATC1(2), NFATC2(7), NFATC3(3), NFATC4(5), NGEF(7), NRP1(5), NTN1(3), NTN4(5), NTNG1(2), PAK1(3), PAK2(2), PAK3(4), PAK4(3), PAK6(3), PAK7(5), PLXNA1(11), PLXNA2(9), PLXNA3(7), PLXNB1(6), PLXNB2(4), PLXNB3(9), PLXNC1(3), PPP3CA(1), PPP3CB(1), PPP3CC(1), PTK2(2), RAC1(1), RAC2(1), RASA1(4), RGS3(11), RHOD(1), RND1(1), ROBO1(7), ROBO2(11), ROBO3(5), ROCK1(4), ROCK2(5), SEMA3A(5), SEMA3C(12), SEMA3D(3), SEMA3F(2), SEMA4A(3), SEMA4B(1), SEMA4C(1), SEMA4D(3), SEMA4F(5), SEMA4G(3), SEMA5B(2), SEMA6A(3), SEMA6B(5), SEMA6C(2), SEMA6D(6), SEMA7A(4), SLIT1(7), SLIT2(8), SLIT3(12), SRGAP1(4), SRGAP2(3), SRGAP3(2), UNC5A(2), UNC5B(2), UNC5C(5), UNC5D(2)	231916627	477	264	472	159	137	78	68	121	72	1	0.0412	1.000	1.000
401	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	126	ACTB(2), ACTG1(2), ACTN1(3), ACTN2(6), ACTN4(2), AKT1(2), AMOTL1(5), ASH1L(5), CASK(2), CDK4(1), CGN(2), CLDN1(1), CLDN11(1), CLDN14(3), CLDN15(1), CLDN16(2), CLDN17(1), CLDN18(1), CLDN19(3), CLDN2(2), CLDN22(1), CLDN4(1), CLDN6(1), CLDN7(1), CLDN8(1), CLDN9(1), CRB3(2), CSNK2A1(2), CSNK2B(3), CTNNA1(2), CTNNA2(5), CTNNA3(5), CTNNB1(3), CTTN(3), EPB41(1), EPB41L1(2), EPB41L2(8), EPB41L3(12), EXOC3(1), EXOC4(3), F11R(2), GNAI1(4), GNAI2(1), GNAI3(2), HCLS1(4), INADL(8), JAM2(4), JAM3(2), LLGL1(5), LLGL2(3), MAGI1(6), MAGI2(6), MAGI3(7), MLLT4(10), MPDZ(12), MRAS(1), MYH1(19), MYH10(8), MYH11(15), MYH13(19), MYH14(7), MYH15(10), MYH2(25), MYH3(11), MYH6(7), MYH7(13), MYH7B(12), MYH9(3), MYL2(2), MYL5(1), OCLN(3), PARD3(3), PARD6A(1), PARD6B(4), PPM1J(4), PPP2CA(4), PPP2CB(1), PPP2R1B(2), PPP2R2A(4), PPP2R2C(3), PPP2R3A(5), PPP2R4(1), PRKCA(6), PRKCD(3), PRKCE(1), PRKCG(4), PRKCH(3), PRKCI(2), PRKCQ(4), RAB3B(1), RRAS(1), SPTAN1(8), SRC(2), SYMPK(6), TJAP1(3), TJP1(8), TJP2(2), TJP3(7), YES1(2), ZAK(5)	219896010	437	255	431	129	175	58	54	94	54	2	0.00299	1.000	1.000
402	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ACTA2(3), ADCY1(5), ADCY2(7), ADCY3(5), ADCY4(6), ADCY5(8), ADCY6(2), ADCY7(3), ADCY8(3), ADCY9(11), ARRB1(2), ARRB2(2), ATF1(1), ATF2(2), ATF4(1), ATF5(2), ATP2A2(4), ATP2A3(4), CACNB3(4), CALCA(1), CALM1(1), CALM3(1), CAMK2A(3), CAMK2D(1), CAMK2G(2), CNN2(2), CORIN(5), DGKZ(3), FOS(2), GABPA(2), GBA2(1), GJA1(5), GNB1(1), GNB2(2), GNB3(1), GNB4(1), GNB5(1), GNG12(1), GNG2(1), GNG5(1), GRK4(5), GRK5(4), GUCY1A3(3), IGFBP2(1), IGFBP6(1), IL1B(3), IL6(2), ITPR1(9), ITPR2(16), ITPR3(18), MIB1(5), MYL2(2), MYLK2(1), NFKB1(2), NOS1(11), NOS3(10), PDE4B(2), PDE4D(6), PLCB3(4), PLCD1(4), PLCG1(12), PLCG2(12), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), PRKCA(6), PRKCD(3), PRKCE(1), PRKCH(3), PRKCQ(4), PRKD1(1), RAMP3(2), RGS1(1), RGS11(1), RGS14(2), RGS18(2), RGS19(1), RGS3(11), RGS4(4), RGS6(3), RGS7(3), RGS9(5), RLN1(1), RYR1(16), RYR2(58), RYR3(29), SFN(3), SLC8A1(3), SP1(1), TNXB(14), USP5(1), YWHAB(2), YWHAH(2), YWHAQ(1)	206740855	434	253	429	150	162	63	53	90	63	3	0.0349	1.000	1.000
403	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	130	ALCAM(2), CADM1(4), CADM3(1), CD2(1), CD22(9), CD226(1), CD274(1), CD276(2), CD28(2), CD4(2), CD40(1), CD40LG(2), CD58(2), CD6(2), CD86(3), CD8A(1), CDH1(4), CDH15(3), CDH2(2), CDH3(3), CDH4(8), CDH5(5), CLDN1(1), CLDN11(1), CLDN14(3), CLDN15(1), CLDN16(2), CLDN17(1), CLDN18(1), CLDN19(3), CLDN2(2), CLDN22(1), CLDN4(1), CLDN6(1), CLDN7(1), CLDN8(1), CLDN9(1), CNTN1(3), CNTN2(4), CNTNAP1(5), CNTNAP2(17), CTLA4(1), ESAM(1), F11R(2), GLG1(3), HLA-A(1), HLA-B(1), HLA-C(1), HLA-DMA(2), HLA-DMB(5), HLA-DOA(2), HLA-DOB(2), HLA-DPB1(1), HLA-DQA1(1), HLA-DQA2(3), HLA-DRA(4), HLA-DRB1(1), HLA-DRB5(1), HLA-E(1), HLA-F(2), ICAM1(3), ICAM2(2), ICOS(1), ICOSLG(4), ITGA4(8), ITGA6(3), ITGA8(6), ITGA9(2), ITGAL(2), ITGAM(7), ITGAV(4), ITGB1(3), ITGB2(5), ITGB7(7), ITGB8(2), JAM2(4), JAM3(2), L1CAM(12), MAG(5), MPZ(1), MPZL1(2), NCAM1(4), NEGR1(5), NEO1(9), NFASC(2), NLGN1(5), NLGN2(4), NLGN3(5), NRCAM(7), NRXN1(9), NRXN2(1), NRXN3(8), OCLN(3), PDCD1(1), PDCD1LG2(1), PTPRC(9), PTPRF(10), PTPRM(10), PVR(3), PVRL1(3), PVRL2(1), PVRL3(2), SDC1(2), SDC2(1), SDC3(1), SDC4(1), SELE(8), SELP(4), SELPLG(3), SIGLEC1(6), SPN(1), VCAM1(2), VCAN(11)	176255925	373	225	368	153	133	63	36	85	56	0	0.441	1.000	1.000
404	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	159	ADORA3(2), ADRA1A(2), ADRA1B(2), ADRA2A(1), ADRA2C(3), ADRB2(1), AGTR1(1), AGTR2(4), AVPR1A(6), AVPR1B(2), AVPR2(4), BDKRB1(1), BRS3(1), C3AR1(3), CCKAR(1), CCKBR(2), CCR1(1), CCR10(1), CCR2(2), CCR3(2), CCR4(3), CCR5(1), CCR6(3), CCR7(1), CCR8(3), CCR9(2), CHML(4), CHRM1(3), CHRM2(3), CHRM3(4), CHRM4(3), CHRM5(4), CMKLR1(1), CNR1(1), CNR2(3), CX3CR1(3), CXCR4(2), DRD1(1), DRD2(1), DRD3(3), DRD5(10), EDNRA(1), EDNRB(1), F2R(2), F2RL1(4), F2RL3(3), FPR1(1), FSHR(3), GALR1(2), GALT(1), GHSR(2), GNB2L1(2), GPR17(2), GPR173(1), GPR174(2), GPR27(1), GPR35(2), GPR37(5), GPR37L1(1), GPR4(3), GPR50(4), GPR6(3), GPR63(1), GPR83(4), GPR85(4), GPR87(1), GRPR(4), HCRTR1(1), HCRTR2(3), HRH1(3), HRH2(3), HRH3(3), HTR1A(2), HTR1B(3), HTR1D(3), HTR1E(3), HTR1F(3), HTR2A(2), HTR2B(2), HTR2C(4), HTR4(2), HTR5A(8), HTR6(1), HTR7(4), LHCGR(2), LTB4R(1), MC1R(3), MC3R(6), MC4R(6), MC5R(5), MLNR(1), MTNR1A(2), MTNR1B(2), NMBR(6), NMUR1(4), NMUR2(6), NPY1R(3), NPY2R(2), NPY5R(3), NTSR1(4), OPN1SW(1), OPN3(1), OPRD1(2), OPRL1(3), OPRM1(4), OR10A5(2), OR11A1(1), OR1C1(4), OR1F1(2), OR1Q1(1), OR2H1(3), OR5V1(3), OR7A5(1), OR7C1(2), P2RY1(1), P2RY10(1), P2RY12(2), P2RY13(1), P2RY2(3), P2RY6(2), PTAFR(2), PTGER4(2), PTGFR(7), RGR(2), RHO(1), RRH(1), SSTR2(4), SSTR3(6), SUCNR1(3), TBXA2R(1), TRHR(2)	143211092	338	204	333	136	162	47	38	68	23	0	0.0568	1.000	1.000
405	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	36	ACTA2(3), ACTN2(6), ACTN4(2), DES(3), DMD(24), MYBPC1(4), MYBPC2(4), MYBPC3(1), MYH3(11), MYH6(7), MYH7(13), MYL1(2), MYL2(2), MYL3(1), MYOM1(5), NEB(26), TMOD1(1), TNNC2(1), TNNI1(1), TNNT1(4), TNNT2(1), TNNT3(5), TPM1(6), TPM2(1), TPM3(3), TPM4(1), TTN(209), VIM(3)	158167159	350	204	345	101	120	52	39	103	34	2	0.0210	1.000	1.000
406	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADA(1), ADCY1(5), ADCY2(7), ADCY3(5), ADCY4(6), ADCY5(8), ADCY6(2), ADCY7(3), ADCY8(3), ADCY9(11), ADK(1), ADSL(4), ADSSL1(1), AK1(1), AK5(3), AK7(9), ALLC(6), AMPD1(8), AMPD2(4), AMPD3(2), ATIC(1), CANT1(5), DCK(2), ENPP1(5), ENPP3(2), ENTPD1(4), ENTPD5(1), ENTPD6(2), ENTPD8(1), FHIT(1), GART(4), GDA(2), GMPR(1), GMPR2(3), GUCY1A2(2), GUCY1A3(3), GUCY1B3(1), GUCY2C(5), GUCY2D(1), GUCY2F(4), HPRT1(1), IMPDH1(6), NME7(2), NPR1(2), NPR2(3), NT5C(3), NT5C1A(1), NT5C1B(7), NT5C2(1), NT5E(3), NT5M(1), NUDT2(1), PAICS(2), PDE10A(2), PDE11A(6), PDE1A(3), PDE1C(9), PDE2A(5), PDE3B(3), PDE4A(3), PDE4B(2), PDE4C(1), PDE4D(6), PDE5A(1), PDE7A(2), PDE7B(2), PDE8A(7), PDE8B(2), PDE9A(2), PFAS(7), PKLR(3), PNPT1(1), POLA1(3), POLA2(2), POLD1(3), POLD2(2), POLD3(2), POLD4(1), POLE(8), POLE2(1), POLR1A(7), POLR1B(3), POLR2A(9), POLR2B(4), POLR2C(2), POLR2G(1), POLR3A(7), POLR3B(3), POLR3G(1), POLR3GL(1), POLR3K(1), PPAT(2), PRIM1(2), PRIM2(1), PRPS1(1), PRPS1L1(3), PRPS2(5), RRM1(3), RRM2(1), RRM2B(1), XDH(11)	194917930	331	199	329	108	108	62	36	76	49	0	0.0430	1.000	1.000
407	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	147	AKT1(2), CBL(2), CBLB(3), CBLC(2), CCND1(4), CCND2(2), CCND3(1), CISH(1), CLCF1(1), CNTF(1), CNTFR(2), CREBBP(13), CRLF2(3), CSF2(2), CSF2RA(9), CSF2RB(6), CSF3R(3), EP300(6), EPO(2), EPOR(1), GH1(2), GH2(2), GHR(4), IFNA10(2), IFNA5(1), IFNA6(1), IFNA7(1), IFNA8(1), IFNAR1(2), IFNAR2(2), IFNB1(2), IFNG(2), IFNGR1(1), IFNGR2(4), IFNK(1), IFNW1(3), IL10(1), IL10RB(1), IL12B(4), IL12RB1(4), IL12RB2(4), IL13RA1(3), IL13RA2(1), IL15(2), IL15RA(1), IL19(1), IL20(1), IL20RA(2), IL21R(3), IL22(2), IL22RA1(1), IL23A(1), IL23R(5), IL26(3), IL2RB(2), IL3(2), IL3RA(4), IL4R(10), IL5(1), IL5RA(3), IL6(2), IL6R(1), IL6ST(3), IL7(1), IL7R(4), IL9(1), IL9R(2), IRF9(4), JAK1(3), JAK2(5), JAK3(5), LEPR(3), LIFR(2), MPL(5), OSM(1), OSMR(5), PIAS1(2), PIAS3(3), PIAS4(3), PIK3CB(7), PIK3CD(3), PIK3CG(12), PIK3R2(4), PIK3R3(2), PIK3R5(4), PIM1(3), PRL(1), PRLR(2), PTPN6(1), SOCS1(1), SOCS4(3), SOCS5(2), SOS1(7), SOS2(5), SPRED1(1), SPRED2(3), SPRY1(1), SPRY2(3), SPRY3(3), SPRY4(3), STAM(2), STAM2(2), STAT1(4), STAT2(2), STAT3(3), STAT4(4), STAT5A(1), STAT5B(2), STAT6(5), TPO(10), TYK2(10)	166846810	330	196	329	106	93	48	42	99	47	1	0.0815	1.000	1.000
408	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	126	ACACA(17), ACACB(18), AKT1(2), ARAF(1), CALM1(1), CALM3(1), CALML3(1), CALML6(1), CBL(2), CBLB(3), CBLC(2), CRKL(2), ELK1(5), EXOC7(3), FASN(3), FBP1(3), FBP2(2), FLOT1(1), FLOT2(3), FOXO1(1), G6PC(8), G6PC2(1), GCK(2), GSK3B(1), GYS1(1), GYS2(2), IKBKB(2), INPP5D(5), INS(1), INSR(6), IRS1(8), IRS2(1), IRS4(8), LIPE(4), MAP2K1(1), MAP2K2(1), MAPK1(4), MAPK10(1), MAPK3(2), MAPK8(2), MAPK9(1), MKNK1(2), PCK1(6), PDE3A(5), PDE3B(3), PFKL(6), PFKP(1), PHKA1(5), PHKA2(5), PHKB(1), PHKG1(3), PIK3CB(7), PIK3CD(3), PIK3CG(12), PIK3R2(4), PIK3R3(2), PIK3R5(4), PKLR(3), PPARGC1A(1), PPP1CA(1), PPP1CB(1), PPP1CC(1), PPP1R3A(13), PPP1R3C(1), PRKAA1(3), PRKAA2(2), PRKACG(1), PRKAG1(1), PRKAG2(2), PRKAG3(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), PRKCI(2), PRKX(1), PTPN1(1), PTPRF(10), PYGB(3), PYGL(6), PYGM(2), RAF1(2), RAPGEF1(4), RHOQ(1), RPS6KB1(2), RPS6KB2(3), SH2B2(2), SHC1(1), SHC2(1), SHC3(1), SHC4(2), SLC2A4(2), SOCS1(1), SOCS4(3), SORBS1(3), SOS1(7), SOS2(5), SREBF1(7), TRIP10(1), TSC1(2), TSC2(6)	184155687	319	195	319	115	99	50	34	88	45	3	0.232	1.000	1.000
409	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	88	ADCY1(5), ADCY2(7), ADCY3(5), ADCY4(6), ADCY5(8), ADCY6(2), ADCY7(3), ADCY8(3), ADCY9(11), CSNK1D(2), DRD1(1), DRD2(1), EGF(10), GJA1(5), GJD2(3), GNA11(1), GNAI1(4), GNAI2(1), GNAI3(2), GNAS(4), GRM1(6), GRM5(6), GUCY1A2(2), GUCY1A3(3), GUCY1B3(1), GUCY2C(5), GUCY2D(1), GUCY2F(4), HTR2A(2), HTR2B(2), HTR2C(4), ITPR1(9), ITPR2(16), ITPR3(18), MAP2K1(1), MAP2K2(1), MAP2K5(2), MAPK1(4), MAPK3(2), MAPK7(6), NPR1(2), NPR2(3), PDGFA(1), PDGFC(2), PDGFD(4), PDGFRB(4), PLCB1(4), PLCB2(7), PLCB3(4), PLCB4(4), PRKACG(1), PRKCA(6), PRKCG(4), PRKG1(2), PRKG2(6), PRKX(1), RAF1(2), SOS1(7), SOS2(5), SRC(2), TJP1(8), TUBA1A(4), TUBA1B(1), TUBA3C(10), TUBA3D(2), TUBA4A(2), TUBA8(2), TUBB(1), TUBB6(3), TUBB8(3)	151049685	286	188	285	104	108	43	32	54	46	3	0.193	1.000	1.000
410	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	142	APC(3), APC2(3), AXIN1(4), AXIN2(2), BTRC(2), CAMK2A(3), CAMK2D(1), CAMK2G(2), CCND1(4), CCND2(2), CCND3(1), CHD8(11), CREBBP(13), CSNK1A1(2), CSNK1A1L(2), CSNK1E(1), CSNK2A1(2), CSNK2B(3), CTBP1(5), CTBP2(4), CTNNB1(3), CUL1(4), CXXC4(2), DAAM1(1), DAAM2(3), DKK1(2), DKK2(5), DKK4(2), DVL1(1), DVL2(3), DVL3(3), EP300(6), FBXW11(1), FZD1(3), FZD10(5), FZD2(1), FZD4(1), FZD5(1), FZD6(2), FZD7(2), FZD8(2), FZD9(4), GSK3B(1), LEF1(1), LRP5(7), LRP6(9), MAP3K7(3), MAPK10(1), MAPK8(2), MAPK9(1), MMP7(2), NFAT5(4), NFATC1(2), NFATC2(7), NFATC3(3), NFATC4(5), NKD1(2), NKD2(4), NLK(1), PLCB1(4), PLCB2(7), PLCB3(4), PLCB4(4), PORCN(8), PPP2CA(4), PPP2CB(1), PPP2R1B(2), PPP2R2A(4), PPP2R2C(3), PPP3CA(1), PPP3CB(1), PPP3CC(1), PRICKLE1(2), PRICKLE2(4), PRKACG(1), PRKCA(6), PRKCG(4), PRKX(1), PSEN1(1), RAC1(1), RAC2(1), RBX1(1), ROCK1(4), ROCK2(5), RUVBL1(2), SENP2(3), SFRP1(1), SFRP2(2), SFRP4(1), SIAH1(3), SMAD2(3), SMAD3(3), SMAD4(1), SOX17(4), TBL1X(1), TBL1XR1(3), TBL1Y(1), TCF7L2(5), VANGL1(2), VANGL2(2), WIF1(4), WNT1(1), WNT10A(2), WNT11(5), WNT16(2), WNT2B(2), WNT3(1), WNT3A(1), WNT5B(2), WNT7A(2), WNT8A(2), WNT8B(1), WNT9A(2), WNT9B(2)	191292169	323	186	321	102	104	46	38	71	63	1	0.0529	1.000	1.000
411	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	70	CALM1(1), CALM3(1), CALML3(1), CALML6(1), CDS2(2), DGKA(4), DGKB(3), DGKD(8), DGKE(3), DGKG(4), DGKH(4), DGKI(2), DGKQ(3), DGKZ(3), INPP1(1), INPP4A(1), INPP4B(5), INPP5A(1), INPP5B(4), INPP5D(5), INPP5E(1), INPPL1(8), ITPK1(3), ITPR1(9), ITPR2(16), ITPR3(18), OCRL(7), PI4KA(8), PI4KB(4), PIK3C2A(5), PIK3C2B(3), PIK3C2G(10), PIK3C3(2), PIK3CB(7), PIK3CD(3), PIK3CG(12), PIK3R2(4), PIK3R3(2), PIK3R5(4), PIP4K2A(1), PIP4K2B(1), PIP4K2C(5), PIP5K1B(3), PIP5K1C(2), PLCB1(4), PLCB2(7), PLCB3(4), PLCB4(4), PLCD1(4), PLCD3(2), PLCE1(10), PLCG1(12), PLCG2(12), PLCZ1(6), PRKCA(6), PRKCG(4), PTPMT1(1), SYNJ1(6), SYNJ2(11)	143397902	288	180	286	87	98	49	32	67	40	2	0.0175	1.000	1.000
412	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	92	ADCY1(5), ADCY2(7), ADCY3(5), ADCY4(6), ADCY5(8), ADCY6(2), ADCY7(3), ADCY8(3), ADCY9(11), ATF4(1), CACNA1C(7), CACNA1D(11), CACNA1F(7), CACNA1S(14), CALM1(1), CALM3(1), CALML3(1), CALML6(1), CAMK2A(3), CAMK2D(1), CAMK2G(2), CGA(1), ELK1(5), GNA11(1), GNAS(4), GNRHR(3), HBEGF(1), ITPR1(9), ITPR2(16), ITPR3(18), MAP2K1(1), MAP2K2(1), MAP2K3(6), MAP3K1(10), MAP3K3(2), MAP3K4(7), MAPK1(4), MAPK10(1), MAPK12(2), MAPK13(2), MAPK3(2), MAPK7(6), MAPK8(2), MAPK9(1), PLA2G12B(1), PLA2G2D(1), PLA2G2F(1), PLA2G3(5), PLA2G4A(7), PLA2G5(1), PLA2G6(3), PLCB1(4), PLCB2(7), PLCB3(4), PLCB4(4), PLD1(8), PRKACG(1), PRKCA(6), PRKCD(3), PRKX(1), PTK2B(5), RAF1(2), SOS1(7), SOS2(5), SRC(2)	148012247	283	180	279	97	110	47	33	52	38	3	0.0459	1.000	1.000
413	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	107	ACTN1(3), ACTN2(6), ACTN4(2), ARHGAP5(5), BCAR1(3), CDH5(5), CLDN1(1), CLDN11(1), CLDN14(3), CLDN15(1), CLDN16(2), CLDN17(1), CLDN18(1), CLDN19(3), CLDN2(2), CLDN22(1), CLDN4(1), CLDN6(1), CLDN7(1), CLDN8(1), CLDN9(1), CTNNA1(2), CTNNA2(5), CTNNA3(5), CTNNB1(3), CTNND1(1), CXCR4(2), CYBA(1), CYBB(2), ESAM(1), EZR(4), F11R(2), GNAI1(4), GNAI2(1), GNAI3(2), ICAM1(3), ITGA4(8), ITGAL(2), ITGAM(7), ITGB1(3), ITGB2(5), ITK(1), JAM2(4), JAM3(2), MAPK12(2), MAPK13(2), MLLT4(10), MMP9(4), MSN(2), MYL2(2), MYL5(1), NCF1(3), NCF2(6), NCF4(1), NOX1(1), NOX3(5), OCLN(3), PIK3CB(7), PIK3CD(3), PIK3CG(12), PIK3R2(4), PIK3R3(2), PIK3R5(4), PLCG1(12), PLCG2(12), PRKCA(6), PRKCG(4), PTK2(2), PTK2B(5), PXN(1), RAC1(1), RAC2(1), RAPGEF3(2), RAPGEF4(3), RASSF5(1), RHOH(1), ROCK1(4), ROCK2(5), SIPA1(3), TXK(3), VASP(1), VAV1(9), VAV2(4), VAV3(3), VCAM1(2), VCL(1)	142408780	275	179	272	124	102	37	31	66	37	2	0.840	1.000	1.000
414	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	79	AGL(7), AMY2B(6), ASCC3(7), ATP13A2(3), DDX18(1), DDX19A(2), DDX23(3), DDX4(5), DDX41(5), DDX47(2), DDX51(3), DDX52(2), DDX54(2), DDX55(1), DDX56(4), DHX58(2), ENPP1(5), ENPP3(2), ENTPD7(2), EP400(9), ERCC2(3), ERCC3(2), G6PC(8), G6PC2(1), GAA(6), GANC(5), GBE1(1), GCK(2), GPI(2), GUSB(3), GYS1(1), GYS2(2), HK1(4), HK2(5), HK3(5), IFIH1(4), LYZL1(1), MGAM(14), MOV10L1(7), PGM1(1), PGM3(1), PYGB(3), PYGL(6), PYGM(2), RAD54B(5), RAD54L(6), RUVBL2(4), SETX(5), SI(12), SKIV2L2(3), SMARCA2(5), SMARCA5(3), UGDH(1), UGP2(1), UGT1A1(5), UGT1A10(2), UGT1A3(3), UGT1A4(1), UGT1A5(3), UGT1A6(4), UGT1A7(3), UGT1A9(2), UGT2A1(9), UGT2B10(4), UGT2B11(5), UGT2B15(3), UGT2B17(2), UGT2B28(8), UGT2B4(10), UGT2B7(4), UXS1(4)	146337813	279	176	277	78	94	42	32	75	36	0	0.0159	1.000	1.000
415	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	66	A2M(8), BDKRB1(1), C1QA(2), C1QB(1), C1QC(1), C1R(2), C1S(5), C2(7), C3(19), C3AR1(3), C4BPA(6), C4BPB(2), C5(7), C5AR1(4), C6(4), C7(5), C8A(4), C8B(7), C9(2), CD46(5), CD55(2), CD59(1), CFB(2), CFD(1), CFH(10), CFI(1), CPB2(1), CR1(5), CR2(9), F10(2), F12(1), F13A1(5), F13B(5), F2(4), F2R(2), F5(13), F7(2), F8(26), FGA(12), FGB(4), FGG(6), KLKB1(7), KNG1(4), MASP1(2), MASP2(1), MBL2(4), PLAT(3), PLG(6), PROS1(3), SERPINA1(2), SERPINA5(2), SERPINC1(2), SERPIND1(2), SERPINE1(4), SERPINF2(1), SERPING1(4), VWF(14)	106823391	270	174	268	79	84	50	32	67	37	0	0.00641	1.000	1.000
416	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	106	ABL1(6), ANAPC1(3), ANAPC10(1), ANAPC2(2), ANAPC4(2), ANAPC5(4), ANAPC7(2), ATM(12), ATR(10), BUB1(5), BUB1B(2), BUB3(3), CCNA1(3), CCNA2(1), CCNB1(2), CCNB2(1), CCNB3(6), CCND1(4), CCND2(2), CCND3(1), CCNE1(2), CCNE2(2), CCNH(2), CDC14A(2), CDC14B(5), CDC16(2), CDC20(1), CDC23(4), CDC25A(1), CDC25B(1), CDC27(5), CDC6(1), CDC7(2), CDK2(1), CDK4(1), CDK6(1), CDK7(1), CDKN1A(2), CDKN1B(4), CDKN2A(6), CDKN2B(2), CHEK1(6), CHEK2(3), CREBBP(13), CUL1(4), DBF4(6), E2F1(1), E2F2(1), E2F3(1), EP300(6), ESPL1(9), FZR1(4), GADD45B(1), GSK3B(1), HDAC2(7), MAD1L1(1), MCM2(2), MCM3(3), MCM4(5), MCM5(3), MCM6(6), MCM7(6), MDM2(5), PKMYT1(1), PLK1(2), PRKDC(14), RBL1(6), RBL2(4), RBX1(1), SFN(3), SKP2(3), SMAD2(3), SMAD3(3), SMAD4(1), SMC1A(11), SMC1B(9), TFDP1(1), TGFB2(2), TGFB3(1), WEE1(2), YWHAB(2), YWHAE(3), YWHAG(1), YWHAH(2), YWHAQ(1), YWHAZ(1)	158728422	291	170	290	78	44	57	44	87	56	3	0.0247	1.000	1.000
417	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	81	ACVR1(3), ACVR1B(4), ACVRL1(6), AKT1(2), AURKB(1), BMPR1A(1), BMPR2(1), BUB1(5), CDKL1(2), CDKL2(2), CDS2(2), CLK1(2), CLK2(1), CLK4(2), CSNK2A1(2), CSNK2B(3), DGKA(4), DGKB(3), DGKD(8), DGKE(3), DGKG(4), DGKH(4), DGKQ(3), DGKZ(3), INPP1(1), INPP4A(1), INPP4B(5), INPP5A(1), INPPL1(8), MAP3K10(1), NEK1(4), NEK3(4), OCRL(7), PAK4(3), PIK3C2A(5), PIK3C2B(3), PIK3C2G(10), PIK3CB(7), PIK3CG(12), PIM2(4), PLCB1(4), PLCB2(7), PLCB3(4), PLCB4(4), PLCD1(4), PLCG1(12), PLCG2(12), PLK3(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), PRKCA(6), PRKCD(3), PRKCE(1), PRKCG(4), PRKCH(3), PRKCQ(4), PRKD1(1), PRKG1(2), RAF1(2), RPS6KA1(5), RPS6KA2(6), RPS6KA3(4), RPS6KB1(2), STK11(1), TGFBR1(4), VRK1(3)	132103149	252	169	249	83	77	41	33	57	41	3	0.184	1.000	1.000
418	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	119	ARAF(1), CD244(2), CSF2(2), FAS(1), FASLG(1), FCGR3A(1), FYN(2), GZMB(3), HLA-A(1), HLA-B(1), HLA-C(1), HLA-E(1), ICAM1(3), ICAM2(2), IFNA10(2), IFNA5(1), IFNA6(1), IFNA7(1), IFNA8(1), IFNAR1(2), IFNAR2(2), IFNB1(2), IFNG(2), IFNGR1(1), IFNGR2(4), ITGAL(2), ITGB2(5), KIR2DL3(3), KIR3DL1(3), KIR3DL2(1), KLRC1(3), KLRC2(1), KLRC3(4), KLRD1(1), KLRK1(1), LAT(2), LCK(1), LCP2(1), MAP2K1(1), MAP2K2(1), MAPK1(4), MAPK3(2), MICA(4), MICB(2), NCR1(3), NFAT5(4), NFATC1(2), NFATC2(7), NFATC3(3), NFATC4(5), PAK1(3), PIK3CB(7), PIK3CD(3), PIK3CG(12), PIK3R2(4), PIK3R3(2), PIK3R5(4), PLCG1(12), PLCG2(12), PPP3CA(1), PPP3CB(1), PPP3CC(1), PRF1(3), PRKCA(6), PRKCG(4), PTK2B(5), PTPN6(1), RAC1(1), RAC2(1), RAF1(2), SH2D1A(3), SH2D1B(3), SH3BP2(1), SHC1(1), SHC2(1), SHC3(1), SHC4(2), SOS1(7), SOS2(5), TNF(1), TNFRSF10C(1), TNFRSF10D(1), TNFSF10(2), ULBP1(2), ULBP3(5), VAV1(9), VAV2(4), VAV3(3), ZAP70(8)	126177407	252	166	249	96	68	40	31	67	43	3	0.346	1.000	1.000
419	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	71	ARAF(1), CACNA1A(5), GNA11(1), GNA13(2), GNAI1(4), GNAI2(1), GNAI3(2), GNAO1(2), GNAS(4), GNAZ(1), GRIA1(7), GRIA2(2), GRIA3(9), GRID2(5), GRM1(6), GRM5(6), GUCY1A2(2), GUCY1A3(3), GUCY1B3(1), GUCY2C(5), GUCY2D(1), GUCY2F(4), IGF1(3), IGF1R(10), ITPR1(9), ITPR2(16), ITPR3(18), LYN(2), MAP2K1(1), MAP2K2(1), MAPK1(4), MAPK3(2), NOS1(11), NOS3(10), NPR1(2), NPR2(3), PLA2G12B(1), PLA2G2D(1), PLA2G2F(1), PLA2G3(5), PLA2G4A(7), PLA2G5(1), PLA2G6(3), PLCB1(4), PLCB2(7), PLCB3(4), PLCB4(4), PPP2CA(4), PPP2CB(1), PPP2R1B(2), PPP2R2A(4), PPP2R2C(3), PRKCA(6), PRKCG(4), PRKG1(2), PRKG2(6), RAF1(2), RYR1(16)	128858304	254	164	254	90	78	40	37	53	43	3	0.197	1.000	1.000
420	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	95	ADCY1(5), ADCY2(7), ADCY3(5), ADCY4(6), ADCY5(8), ADCY6(2), ADCY7(3), ADCY8(3), ADCY9(11), ASIP(1), CALM1(1), CALM3(1), CALML3(1), CALML6(1), CAMK2A(3), CAMK2D(1), CAMK2G(2), CREB1(2), CREB3L1(2), CREB3L2(1), CREB3L3(3), CREB3L4(1), CREBBP(13), CTNNB1(3), DCT(1), DVL1(1), DVL2(3), DVL3(3), EDNRB(1), EP300(6), FZD1(3), FZD10(5), FZD2(1), FZD4(1), FZD5(1), FZD6(2), FZD7(2), FZD8(2), FZD9(4), GNAI1(4), GNAI2(1), GNAI3(2), GNAO1(2), GNAS(4), GSK3B(1), KIT(9), KITLG(3), LEF1(1), MAP2K1(1), MAP2K2(1), MAPK1(4), MAPK3(2), MC1R(3), PLCB1(4), PLCB2(7), PLCB3(4), PLCB4(4), PRKACG(1), PRKCA(6), PRKCG(4), PRKX(1), RAF1(2), TCF7L2(5), TYR(5), WNT1(1), WNT10A(2), WNT11(5), WNT16(2), WNT2B(2), WNT3(1), WNT3A(1), WNT5B(2), WNT7A(2), WNT8A(2), WNT8B(1), WNT9A(2), WNT9B(2)	126946138	228	160	228	76	87	27	29	45	38	2	0.107	1.000	1.000
421	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(7), ABCA10(5), ABCA12(5), ABCA13(22), ABCA2(4), ABCA3(6), ABCA4(11), ABCA5(7), ABCA6(9), ABCA7(12), ABCA8(5), ABCA9(6), ABCB1(15), ABCB10(3), ABCB11(3), ABCB4(12), ABCB5(9), ABCB6(1), ABCB7(6), ABCB8(2), ABCB9(4), ABCC1(6), ABCC10(13), ABCC11(8), ABCC12(4), ABCC2(1), ABCC3(7), ABCC4(8), ABCC5(7), ABCC6(2), ABCC8(7), ABCC9(20), ABCD1(3), ABCD2(5), ABCD3(2), ABCG1(3), ABCG2(3), ABCG4(4), ABCG5(4), ABCG8(5), CFTR(6), TAP1(2), TAP2(1)	141135987	275	158	272	99	83	41	39	78	31	3	0.228	1.000	1.000
422	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	74	ACP1(1), ACTB(2), ACTG1(2), ACTN1(3), ACTN2(6), ACTN4(2), ACVR1B(4), ACVR1C(3), BAIAP2(3), CDH1(4), CREBBP(13), CSNK2A1(2), CSNK2B(3), CTNNA1(2), CTNNA2(5), CTNNA3(5), CTNNB1(3), CTNND1(1), EP300(6), ERBB2(3), FARP2(2), FER(1), FGFR1(3), FYN(2), IGF1R(10), INSR(6), IQGAP1(9), LEF1(1), LMO7(8), MAP3K7(3), MAPK1(4), MAPK3(2), MET(13), MLLT4(10), NLK(1), PARD3(3), PTPN1(1), PTPN6(1), PTPRB(10), PTPRF(10), PTPRJ(5), PTPRM(10), PVRL1(3), PVRL2(1), PVRL3(2), PVRL4(4), RAC1(1), RAC2(1), SMAD2(3), SMAD3(3), SMAD4(1), SNAI2(2), SORBS1(3), SRC(2), SSX2IP(1), TCF7L2(5), TGFBR1(4), TGFBR2(5), TJP1(8), VCL(1), WAS(3), WASF1(1), WASF2(1), WASF3(4), WASL(2), YES1(2)	139573148	251	157	251	77	74	32	33	66	45	1	0.0531	1.000	1.000
423	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADA(1), ADCY1(5), ADCY2(7), ADCY3(5), ADCY4(6), ADCY5(8), ADCY6(2), ADCY7(3), ADCY8(3), ADK(1), ADSL(4), AK1(1), AK5(3), ALLC(6), AMPD1(8), AMPD2(4), AMPD3(2), ATIC(1), ATP1B1(1), ATP5A1(1), ATP5B(3), ATP5G2(1), ATP5I(1), CANT1(5), DCK(2), ENPP1(5), ENPP3(2), ENTPD1(4), FHIT(1), GART(4), GDA(2), GUCY1A2(2), GUCY1A3(3), GUCY1B3(1), GUCY2C(5), GUCY2D(1), GUCY2F(4), HPRT1(1), IMPDH1(6), NPR1(2), NPR2(3), NT5C(3), NT5E(3), NT5M(1), NUDT2(1), PAICS(2), PDE1A(3), PDE4A(3), PDE4B(2), PDE4C(1), PDE4D(6), PDE5A(1), PDE6B(5), PDE6C(7), PDE7B(2), PDE8A(7), PDE9A(2), PFAS(7), PKLR(3), POLB(3), POLD1(3), POLD2(2), POLE(8), POLG(1), POLL(2), POLQ(8), POLR1B(3), POLR2A(9), POLR2B(4), POLR2C(2), POLR2G(1), POLRMT(3), PPAT(2), PRPS1(1), PRPS1L1(3), PRPS2(5), RRM1(3), RRM2(1)	153110990	253	157	253	94	86	48	24	60	35	0	0.340	1.000	1.000
424	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(2), BCAR1(3), CAPN1(2), CAPN10(4), CAPN11(6), CAPN3(3), CAPN5(2), CAPN6(3), CAPN7(1), CAPN9(5), CAPNS1(2), CAV3(1), CSK(2), DOCK1(3), FYN(2), ILK(1), ITGA10(5), ITGA11(3), ITGA2(5), ITGA2B(2), ITGA3(1), ITGA4(8), ITGA5(3), ITGA6(3), ITGA7(4), ITGA8(6), ITGA9(2), ITGAD(6), ITGAE(7), ITGAL(2), ITGAM(7), ITGAV(4), ITGAX(8), ITGB1(3), ITGB2(5), ITGB3(3), ITGB4(8), ITGB6(9), ITGB7(7), ITGB8(2), MAP2K1(1), MAP2K2(1), MAP2K3(6), MAPK10(1), MAPK12(2), MAPK4(2), MAPK7(6), MYLK2(1), PAK1(3), PAK2(2), PAK3(4), PAK4(3), PAK6(3), PIK3R2(4), PTK2(2), PXN(1), RAC1(1), RAC2(1), RAPGEF1(4), RHO(1), ROCK1(4), ROCK2(5), SDCCAG8(4), SHC1(1), SHC3(1), SORBS1(3), SOS1(7), SRC(2), TLN1(5), TNS1(6), VASP(1), VAV2(4), VAV3(3), VCL(1), ZYX(2)	159914935	253	154	252	90	85	35	33	63	36	1	0.213	1.000	1.000
425	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	90	ADCY1(5), ADCY2(7), ADCY3(5), ADCY4(6), ADCY5(8), ADCY6(2), ADCY7(3), ADCY8(3), ADCY9(11), AKAP1(2), AKAP11(3), AKAP12(1), AKAP2(6), AKAP3(2), AKAP4(8), AKAP5(3), AKAP6(12), AKAP7(1), AKAP8(5), AKAP9(15), ARHGEF1(1), CALM1(1), CALM3(1), GNA11(1), GNA13(2), GNA14(3), GNA15(1), GNAI2(1), GNAI3(2), GNAL(1), GNAO1(2), GNAZ(1), GNB1(1), GNB2(2), GNB3(1), GNB5(1), GNG12(1), GNG5(1), GNGT2(1), ITPR1(9), KCNJ3(2), PALM2(2), PDE1A(3), PDE1B(2), PDE1C(9), PDE4A(3), PDE4B(2), PDE4C(1), PDE4D(6), PDE7A(2), PDE7B(2), PDE8A(7), PDE8B(2), PLCB3(4), PPP3CA(1), PPP3CC(1), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), PRKCA(6), PRKCD(3), PRKCE(1), PRKCG(4), PRKCH(3), PRKCI(2), PRKCQ(4), PRKD1(1), PRKD3(2), RRAS(1), USP5(1)	138594165	224	153	223	83	71	39	23	46	43	2	0.330	1.000	1.000
426	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	83	ANPEP(5), CD14(1), CD19(2), CD1A(3), CD1B(5), CD1D(4), CD1E(5), CD2(1), CD22(9), CD33(6), CD36(5), CD37(1), CD38(1), CD3D(1), CD3E(2), CD3G(1), CD4(2), CD44(6), CD5(2), CD55(2), CD59(1), CD7(3), CD8A(1), CR1(5), CR2(9), CSF1R(5), CSF2(2), CSF2RA(9), CSF3R(3), DNTT(3), EPO(2), EPOR(1), FCER2(1), FCGR1A(1), FLT3(8), GP5(2), GP9(1), HLA-DRA(4), HLA-DRB1(1), HLA-DRB5(1), IL1A(1), IL1B(3), IL1R1(4), IL1R2(3), IL3(2), IL3RA(4), IL4R(10), IL5(1), IL5RA(3), IL6(2), IL6R(1), IL7(1), IL7R(4), IL9R(2), ITGA1(4), ITGA2(5), ITGA2B(2), ITGA3(1), ITGA4(8), ITGA5(3), ITGA6(3), ITGAM(7), ITGB3(3), KIT(9), KITLG(3), MME(3), MS4A1(3), TFRC(2), THPO(2), TNF(1), TPO(10)	97235096	237	149	236	79	78	40	26	54	39	0	0.0483	1.000	1.000
427	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	64	ADCY1(5), ADCY8(3), ARAF(1), ATF4(1), CACNA1C(7), CALM1(1), CALM3(1), CALML3(1), CALML6(1), CAMK2A(3), CAMK2D(1), CAMK2G(2), CAMK4(3), CREBBP(13), EP300(6), GRIA1(7), GRIA2(2), GRIN1(2), GRIN2A(18), GRIN2B(10), GRIN2C(6), GRIN2D(5), GRM1(6), GRM5(6), ITPR1(9), ITPR2(16), ITPR3(18), MAP2K1(1), MAP2K2(1), MAPK1(4), MAPK3(2), PLCB1(4), PLCB2(7), PLCB3(4), PLCB4(4), PPP1CA(1), PPP1CB(1), PPP1CC(1), PPP1R12A(1), PPP3CA(1), PPP3CB(1), PPP3CC(1), PRKACG(1), PRKCA(6), PRKCG(4), PRKX(1), RAF1(2), RAPGEF3(2), RPS6KA1(5), RPS6KA2(6), RPS6KA3(4), RPS6KA6(5)	116202108	224	149	224	69	84	27	26	55	29	3	0.0307	1.000	1.000
428	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	108	ALG1(1), ALG10B(3), ALG12(2), ALG13(4), ALG14(1), ALG3(4), ALG6(3), B3GNT2(1), B3GNT7(2), B4GALT2(1), C1GALT1(1), CHPF(1), CHST1(2), CHST11(3), CHST13(3), CHST2(2), CHST3(3), CHST4(2), CHST6(2), CHSY1(4), DAD1(1), DPAGT1(2), EXT1(3), EXT2(3), EXTL1(4), EXTL2(2), EXTL3(1), FUT11(1), FUT8(7), GALNT1(6), GALNT10(1), GALNT11(3), GALNT12(3), GALNT13(4), GALNT14(7), GALNT2(3), GALNT3(1), GALNT4(3), GALNT5(5), GALNT6(4), GALNT7(2), GALNT8(1), GALNT9(4), GALNTL5(1), GANAB(4), GCNT1(2), GCNT3(2), GCNT4(3), HS3ST1(3), HS3ST3A1(3), HS6ST2(4), HS6ST3(1), MAN1A1(3), MAN1A2(1), MAN1B1(1), MAN1C1(2), MAN2A1(4), MGAT1(3), MGAT2(3), MGAT3(3), MGAT4A(1), MGAT5(2), MGAT5B(2), NDST1(2), NDST2(2), NDST3(4), NDST4(8), OGT(9), RPN1(1), RPN2(1), ST3GAL1(3), ST3GAL2(1), ST3GAL3(2), ST3GAL4(3), ST6GAL1(2), ST6GALNAC1(2), STT3B(2), UST(1), WBSCR17(11), XYLT1(3), XYLT2(4)	131514558	225	147	223	71	80	38	28	46	33	0	0.0549	1.000	1.000
429	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	75	ABL1(6), ACTN1(3), ACTR2(2), ACTR3(1), AKT1(2), ANGPTL2(3), ARHGEF6(7), ARHGEF7(2), BCAR1(3), CDKN2A(6), CSE1L(1), DOCK1(3), EPHB2(5), FYN(2), GRB7(6), ILK(1), ITGA1(4), ITGA10(5), ITGA11(3), ITGA2(5), ITGA3(1), ITGA4(8), ITGA5(3), ITGA6(3), ITGA7(4), ITGA8(6), ITGA9(2), MAPK1(4), MAPK10(1), MAPK8(2), MAPK8IP1(3), MAPK8IP2(4), MAPK8IP3(7), MAPK9(1), MRAS(1), MYLK(7), MYLK2(1), P4HB(1), PAK1(3), PAK2(2), PAK3(4), PAK4(3), PAK6(3), PAK7(5), PIK3CB(7), PKLR(3), PLCG1(12), PLCG2(12), PTK2(2), RAF1(2), RALA(2), RHO(1), ROCK1(4), ROCK2(5), SHC1(1), SOS1(7), SOS2(5), SRC(2), TERF2IP(1), TLN1(5), TLN2(9), VASP(1), WAS(3), ZYX(2)	140472751	235	146	230	73	66	33	33	63	40	0	0.0653	1.000	1.000
430	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	78	ABL1(6), ABL2(3), AKT1(2), ARAF(1), AREG(3), BTC(1), CAMK2A(3), CAMK2D(1), CAMK2G(2), CBL(2), CBLB(3), CBLC(2), CDKN1A(2), CDKN1B(4), CRKL(2), EGF(10), ELK1(5), ERBB2(3), ERBB3(4), ERBB4(5), EREG(1), GSK3B(1), HBEGF(1), MAP2K1(1), MAP2K2(1), MAPK1(4), MAPK10(1), MAPK3(2), MAPK8(2), MAPK9(1), NRG1(5), NRG2(1), NRG4(1), PAK1(3), PAK2(2), PAK3(4), PAK4(3), PAK6(3), PAK7(5), PIK3CB(7), PIK3CD(3), PIK3CG(12), PIK3R2(4), PIK3R3(2), PIK3R5(4), PLCG1(12), PLCG2(12), PRKCA(6), PRKCG(4), PTK2(2), RAF1(2), RPS6KB1(2), RPS6KB2(3), SHC1(1), SHC2(1), SHC3(1), SHC4(2), SOS1(7), SOS2(5), SRC(2), STAT5A(1), STAT5B(2), TGFA(4)	111579629	207	137	204	61	58	30	28	50	39	2	0.0519	1.000	1.000
431	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	87	AKT1(2), CARD11(8), CBL(2), CBLB(3), CBLC(2), CD28(2), CD3D(1), CD3E(2), CD3G(1), CD4(2), CD40LG(2), CD8A(1), CDK4(1), CHUK(1), CSF2(2), CTLA4(1), FOS(2), FYN(2), GRAP2(2), ICOS(1), IFNG(2), IKBKB(2), IL10(1), IL5(1), ITK(1), LAT(2), LCK(1), LCP2(1), MALT1(4), MAP3K8(4), NFAT5(4), NFATC1(2), NFATC2(7), NFATC3(3), NFATC4(5), NFKB1(2), NFKB2(3), NFKBIA(3), NFKBIE(3), PAK1(3), PAK2(2), PAK3(4), PAK4(3), PAK6(3), PAK7(5), PDCD1(1), PDK1(2), PIK3CB(7), PIK3CD(3), PIK3CG(12), PIK3R2(4), PIK3R3(2), PIK3R5(4), PLCG1(12), PPP3CA(1), PPP3CB(1), PPP3CC(1), PRKCQ(4), PTPN6(1), PTPRC(9), RASGRP1(2), SOS1(7), SOS2(5), TEC(4), TNF(1), VAV1(9), VAV2(4), VAV3(3), ZAP70(8)	114605941	218	137	214	72	65	41	27	53	30	2	0.127	1.000	1.000
432	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	95	AKT1(2), CASP8(2), CCL3(1), CCL5(1), CD14(1), CD40(1), CD86(3), CHUK(1), CXCL9(1), FOS(2), IFNA10(2), IFNA5(1), IFNA6(1), IFNA7(1), IFNA8(1), IFNAR1(2), IFNAR2(2), IFNB1(2), IKBKB(2), IKBKE(5), IL12B(4), IL1B(3), IL6(2), IRAK1(3), IRAK4(2), IRF3(1), IRF5(2), IRF7(4), LBP(5), LY96(2), MAP2K1(1), MAP2K2(1), MAP2K3(6), MAP3K7(3), MAP3K8(4), MAPK1(4), MAPK10(1), MAPK12(2), MAPK13(2), MAPK3(2), MAPK8(2), MAPK9(1), NFKB1(2), NFKB2(3), NFKBIA(3), PIK3CB(7), PIK3CD(3), PIK3CG(12), PIK3R2(4), PIK3R3(2), PIK3R5(4), RAC1(1), RELA(1), RIPK1(4), SPP1(2), STAT1(4), TBK1(2), TICAM1(1), TLR1(6), TLR2(5), TLR3(6), TLR4(2), TLR5(4), TLR6(8), TLR7(10), TLR8(1), TLR9(5), TNF(1), TOLLIP(1), TRAF3(2), TRAF6(1)	102033191	198	135	195	76	62	38	23	46	27	2	0.289	1.000	1.000
433	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	89	ACVR1(3), ACVR1B(4), ACVR1C(3), ACVR2A(2), ACVRL1(6), AMHR2(2), BMP2(1), BMP4(3), BMP5(8), BMP6(3), BMPR1A(1), BMPR1B(1), BMPR2(1), CDKN2B(2), CHRD(2), COMP(1), CREBBP(13), CUL1(4), DCN(3), E2F4(1), E2F5(1), EP300(6), FST(1), GDF5(2), GDF6(2), GDF7(2), ID1(1), IFNG(2), INHBA(2), INHBB(1), INHBE(3), LEFTY2(4), LTBP1(8), MAPK1(4), MAPK3(2), NODAL(1), PITX2(7), PPP2CA(4), PPP2CB(1), PPP2R1B(2), PPP2R2A(4), PPP2R2C(3), RBL1(6), RBL2(4), RBX1(1), ROCK1(4), ROCK2(5), RPS6KB1(2), RPS6KB2(3), SMAD1(4), SMAD2(3), SMAD3(3), SMAD4(1), SMAD5(1), SMAD6(1), SMAD7(3), SMAD9(3), SMURF1(4), SMURF2(2), SP1(1), TFDP1(1), TGFB2(2), TGFB3(1), TGFBR1(4), TGFBR2(5), THBS1(6), THBS2(6), THBS3(5), THBS4(5), TNF(1), ZFYVE16(2), ZFYVE9(2)	118340329	218	130	218	57	59	35	33	56	34	1	0.00672	1.000	1.000
434	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	80	ABL1(6), ATM(12), BUB1(5), BUB1B(2), BUB3(3), CCNA1(3), CCNA2(1), CCNB1(2), CCNB2(1), CCNB3(6), CCND2(2), CCND3(1), CCNE1(2), CCNE2(2), CCNH(2), CDAN1(5), CDC14A(2), CDC14B(5), CDC20(1), CDC25A(1), CDC25B(1), CDC6(1), CDC7(2), CDH1(4), CDK2(1), CDK4(1), CDKN1A(2), CDKN2A(6), CHEK1(6), CHEK2(3), DTX4(4), E2F1(1), E2F2(1), E2F3(1), E2F4(1), E2F5(1), E2F6(1), EP300(6), ESPL1(9), GSK3B(1), HDAC2(7), HDAC3(1), HDAC4(4), HDAC5(1), HDAC6(4), MAD1L1(1), MCM2(2), MCM3(3), MCM4(5), MCM5(3), MCM6(6), MCM7(6), MDM2(5), MPEG1(3), MPL(5), PLK1(2), PRKDC(14), PTPRA(7), RBL1(6), SKP2(3), SMAD4(1), TBC1D8(4), TFDP1(1), WEE1(2)	128072416	213	126	212	68	44	43	24	62	37	3	0.224	1.000	1.000
435	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	68	ADH1A(3), ADH1B(4), ADH5(1), ADH6(3), ADH7(2), ADHFE1(2), AKR1C1(2), AKR1C2(1), AKR1C3(1), AKR1C4(2), ALDH1A3(5), ALDH3A1(6), ALDH3B2(3), CYP1A2(4), CYP1B1(2), CYP2B6(6), CYP2C18(4), CYP2C19(5), CYP2C8(4), CYP2C9(3), CYP2E1(2), CYP2F1(1), CYP2S1(2), CYP3A4(5), CYP3A43(1), CYP3A5(4), CYP3A7(3), EPHX1(4), GSTA1(3), GSTA2(1), GSTA3(1), GSTA4(4), GSTA5(4), GSTK1(2), GSTM4(1), GSTM5(1), GSTT1(1), GSTZ1(3), UGT1A1(5), UGT1A10(2), UGT1A3(3), UGT1A4(1), UGT1A5(3), UGT1A6(4), UGT1A7(3), UGT1A9(2), UGT2A1(9), UGT2B10(4), UGT2B11(5), UGT2B15(3), UGT2B17(2), UGT2B28(8), UGT2B4(10), UGT2B7(4)	67055718	174	122	172	57	57	22	23	54	18	0	0.178	1.000	1.000
436	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	82	ATF2(2), CHUK(1), CREB1(2), DAXX(5), ELK1(5), FOS(2), IKBKB(2), MAP2K1(1), MAP2K2(1), MAP2K3(6), MAP2K5(2), MAP3K1(10), MAP3K10(1), MAP3K12(6), MAP3K13(4), MAP3K3(2), MAP3K4(7), MAP3K5(4), MAP3K6(1), MAP3K7(3), MAP3K8(4), MAP3K9(6), MAP4K1(3), MAP4K2(1), MAP4K3(5), MAP4K4(4), MAP4K5(1), MAPK1(4), MAPK10(1), MAPK12(2), MAPK13(2), MAPK3(2), MAPK4(2), MAPK7(6), MAPK8(2), MAPK9(1), MAPKAPK2(2), MAPKAPK3(2), MAPKAPK5(2), MEF2A(4), MEF2B(1), MEF2D(1), MKNK1(2), NFKB1(2), NFKBIA(3), PAK1(3), PAK2(2), RAC1(1), RAF1(2), RELA(1), RIPK1(4), RPS6KA1(5), RPS6KA2(6), RPS6KA3(4), RPS6KA5(2), RPS6KB1(2), RPS6KB2(3), SHC1(1), SP1(1), STAT1(4), TGFB2(2), TGFB3(1), TGFBR1(4), TRADD(1), TRAF2(2)	111217891	183	121	180	60	46	31	29	38	37	2	0.178	1.000	1.000
437	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CD2BP2(1), CDC40(2), CLK2(1), CLK3(3), CLK4(2), COL2A1(7), CPSF1(6), CPSF2(2), CPSF3(3), CSTF1(3), CSTF2(4), CSTF3(4), DDIT3(3), DDX20(1), DHX15(1), DHX16(4), DHX38(5), DHX8(8), DHX9(2), DICER1(7), FUS(4), METTL3(4), NCBP1(1), NCBP2(1), NONO(4), NUDT21(1), NXF1(1), PAPOLA(7), PHF5A(3), POLR2A(9), PRPF18(1), PRPF3(1), PRPF4(2), PRPF4B(4), PRPF8(12), PSKH1(1), PTBP1(3), RNGTT(4), SF3A1(2), SF3A2(1), SF3A3(2), SF3B1(8), SF3B2(3), SF3B4(1), SNRPA(1), SNRPB(2), SNRPB2(1), SNRPD2(1), SNRPD3(1), SNRPE(1), SNURF(2), SPOP(4), SRPK1(3), SRPK2(2), SRRM1(3), SUPT5H(2), TXNL4A(1), U2AF1(3), U2AF2(3), XRN2(5)	126082912	184	119	183	44	57	29	21	46	30	1	0.0298	1.000	1.000
438	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	91	ACTB(2), BCL2(2), CABIN1(11), CALM1(1), CALM3(1), CAMK4(3), CD3E(2), CD3G(1), CDKN1A(2), CEBPB(2), CNR1(1), CREBBP(13), CSF2(2), CSNK2A1(2), CSNK2B(3), CTLA4(1), EGR2(3), EGR3(2), EP300(6), FCER1A(4), FCGR3A(1), FOS(2), GATA3(3), GATA4(3), GSK3B(1), ICOS(1), IFNB1(2), IFNG(2), IL10(1), IL1B(3), IL3(2), IL6(2), ITK(1), KPNA5(4), MAPK8(2), MAPK9(1), MEF2A(4), MEF2B(1), MEF2D(1), MYF5(6), NFAT5(4), NFATC1(2), NFATC2(7), NFATC3(3), NFATC4(5), NFKB2(3), NFKBIE(3), NUP214(4), OPRD1(2), P2RX7(1), PAK1(3), PPP3CB(1), PPP3CC(1), PTPRC(9), RELA(1), RPL13A(2), SFN(3), SLA(2), SP1(1), SP3(5), TNF(1), TRAF2(2), VAV1(9), VAV2(4), VAV3(3), XPO5(1)	106716411	189	118	188	60	46	44	21	46	31	1	0.0589	1.000	1.000
439	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(5), ASH2L(2), CARM1(1), CTCFL(5), DOT1L(4), EHMT1(6), EHMT2(5), EZH1(2), EZH2(5), FBXO11(2), HCFC1(8), HSF4(2), JMJD4(2), JMJD6(4), KDM6A(6), MEN1(4), NSD1(5), OGT(9), PAXIP1(2), PPP1CA(1), PPP1CB(1), PPP1CC(1), PRDM2(5), PRDM7(2), PRDM9(18), PRMT1(1), PRMT5(4), PRMT6(1), PRMT7(1), PRMT8(5), RBBP5(3), SATB1(3), SETD1A(4), SETD2(16), SETD7(2), SETD8(1), SETDB1(8), SETDB2(1), SETMAR(3), SMYD3(2), STK38(1), SUV39H1(2), SUV39H2(1), SUV420H1(3), SUZ12(2), WHSC1L1(4)	142009497	175	116	174	46	46	29	24	46	30	0	0.0558	1.000	1.000
440	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	AKT1(2), CALM1(1), CALM3(1), CHRM1(3), CHRNA1(4), FLT1(10), FLT4(8), KDR(14), NOS3(10), PDE2A(5), PDE3A(5), PDE3B(3), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), PRKG1(2), PRKG2(6), RYR2(58), SLC7A1(3), SYT1(3), TNNI1(1)	48393714	144	116	143	44	52	23	26	24	19	0	0.0320	1.000	1.000
441	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	70	AKT1(2), BTK(4), CSF2(2), FCER1A(4), FYN(2), GAB2(4), IL3(2), IL5(1), INPP5D(5), LAT(2), LCP2(1), LYN(2), MAP2K1(1), MAP2K2(1), MAP2K3(6), MAPK1(4), MAPK10(1), MAPK12(2), MAPK13(2), MAPK3(2), MAPK8(2), MAPK9(1), PDK1(2), PIK3CB(7), PIK3CD(3), PIK3CG(12), PIK3R2(4), PIK3R3(2), PIK3R5(4), PLA2G12B(1), PLA2G2D(1), PLA2G2F(1), PLA2G3(5), PLA2G4A(7), PLA2G5(1), PLA2G6(3), PLCG1(12), PLCG2(12), PRKCA(6), PRKCD(3), PRKCE(1), RAC1(1), RAC2(1), RAF1(2), SOS1(7), SOS2(5), TNF(1), VAV1(9), VAV2(4), VAV3(3)	80556688	173	115	170	57	54	31	23	39	23	3	0.115	1.000	1.000
442	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	69	ACACB(18), ACSL1(4), ACSL3(3), ACSL4(6), ACSL6(3), ADIPOR1(2), ADIPOR2(3), AGRP(1), AKT1(2), CAMKK1(2), CAMKK2(2), CD36(5), CHUK(1), CPT1A(2), CPT1C(2), CPT2(2), G6PC(8), G6PC2(1), IKBKB(2), IRS1(8), IRS2(1), IRS4(8), JAK1(3), JAK2(5), JAK3(5), LEPR(3), MAPK10(1), MAPK8(2), MAPK9(1), NFKB1(2), NFKB2(3), NFKBIA(3), NFKBIE(3), NPY(3), PCK1(6), PPARA(4), PPARGC1A(1), PRKAA1(3), PRKAA2(2), PRKAG1(1), PRKAG2(2), PRKAG3(1), PRKCQ(4), RELA(1), RXRA(4), RXRG(3), SLC2A1(4), SLC2A4(2), STAT3(3), STK11(1), TNF(1), TNFRSF1A(1), TNFRSF1B(3), TRADD(1), TRAF2(2), TYK2(10)	97507737	180	114	180	65	59	32	11	46	31	1	0.254	1.000	1.000
443	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	64	AGTR1(1), AGTR2(4), ATP8A1(5), AVPR1A(6), AVPR1B(2), AVPR2(4), BDKRB1(1), BRS3(1), C3AR1(3), CCKAR(1), CCKBR(2), CCR1(1), CCR10(1), CCR2(2), CCR3(2), CCR4(3), CCR5(1), CCR6(3), CCR7(1), CCR8(3), CX3CR1(3), CXCR4(2), CXCR6(1), EDNRA(1), EDNRB(1), FPR1(1), FSHR(3), GALR1(2), GALT(1), GHSR(2), GNB2L1(2), GNRHR(3), GRPR(4), LHCGR(2), MC1R(3), MC2R(2), MC3R(6), MC4R(6), MC5R(5), NMBR(6), NPY1R(3), NPY2R(2), NPY5R(3), NTSR1(4), OPRD1(2), OPRL1(3), OPRM1(4), SSTR2(4), SSTR3(6), TACR2(2), TACR3(7), TRHR(2), TSHR(5)	60645446	150	113	150	68	66	19	25	33	7	0	0.521	1.000	1.000
444	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	52	ADORA3(2), ALG6(3), CCKBR(2), CCR2(2), CCR3(2), CCR5(1), CELSR1(13), CELSR2(14), CELSR3(18), CHRM2(3), CHRM3(4), EDNRA(1), EMR2(6), EMR3(2), F2R(2), FSHR(3), GHRHR(3), GNRHR(3), GPR116(12), GPR132(7), GPR133(7), GPR143(6), GPR17(2), GPR18(2), GPR61(4), GPR84(2), GRM1(6), GRPR(4), HRH4(2), LGR6(1), LPHN2(8), LPHN3(7), LTB4R2(1), NTSR1(4), OR2M4(2), P2RY13(1), PTGFR(7), SMO(3), SSTR2(4), TAAR5(1), TSHR(5), VN1R1(1)	79533333	183	111	181	77	69	32	23	45	14	0	0.427	1.000	1.000
445	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	65	AKT1(2), CASP9(1), KDR(14), MAP2K1(1), MAP2K2(1), MAPK1(4), MAPK12(2), MAPK13(2), MAPK3(2), MAPKAPK2(2), MAPKAPK3(2), NFAT5(4), NFATC1(2), NFATC2(7), NFATC3(3), NFATC4(5), NOS3(10), PIK3CB(7), PIK3CD(3), PIK3CG(12), PIK3R2(4), PIK3R3(2), PIK3R5(4), PLA2G12B(1), PLA2G2D(1), PLA2G2F(1), PLA2G3(5), PLA2G4A(7), PLA2G5(1), PLA2G6(3), PLCG1(12), PLCG2(12), PPP3CA(1), PPP3CB(1), PPP3CC(1), PRKCA(6), PRKCG(4), PTGS2(3), PTK2(2), PXN(1), RAC1(1), RAC2(1), RAF1(2), SH2D2A(1), SHC2(1), SRC(2), VEGFA(3)	80510237	169	109	167	53	54	29	21	36	27	2	0.0307	1.000	1.000
446	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	44	AKT1(2), BCL2(2), BCR(3), BLNK(2), BTK(4), CD19(2), CD22(9), CD81(2), CR2(9), CSK(2), DAG1(3), FLOT1(1), FLOT2(3), GSK3B(1), INPP5D(5), ITPR1(9), ITPR2(16), ITPR3(18), LYN(2), MAP4K1(3), MAPK1(4), MAPK3(2), NFATC1(2), NFATC2(7), NR0B2(1), PDK1(2), PIK3CD(3), PLCG2(12), PPP1R13B(2), PPP3CA(1), PPP3CB(1), PPP3CC(1), PTPRC(9), RAF1(2), SHC1(1), SOS1(7), SOS2(5), VAV1(9)	83760463	169	109	169	57	58	29	18	39	23	2	0.0922	1.000	1.000
447	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	45	INPP1(1), INPP4A(1), INPP4B(5), INPP5A(1), INPP5B(4), INPP5E(1), INPPL1(8), IPMK(2), ISYNA1(2), ITPK1(3), MINPP1(1), MIOX(1), OCRL(7), PI4KA(8), PI4KB(4), PIK3C3(2), PIK3CB(7), PIK3CD(3), PIK3CG(12), PIP4K2A(1), PIP4K2B(1), PIP4K2C(5), PIP5K1B(3), PIP5K1C(2), PLCB1(4), PLCB2(7), PLCB3(4), PLCB4(4), PLCD1(4), PLCD3(2), PLCE1(10), PLCG1(12), PLCG2(12), PLCZ1(6), PTPMT1(1), SYNJ1(6), SYNJ2(11)	85103578	168	108	166	55	47	29	18	48	26	0	0.242	1.000	1.000
448	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	77	AIFM1(7), AKT1(2), APAF1(3), ATM(12), BAX(1), BCL2(2), BIRC2(3), BIRC3(1), CAPN1(2), CASP10(1), CASP8(2), CASP9(1), CFLAR(1), CHUK(1), CSF2RB(6), CYCS(2), DFFA(2), FAS(1), FASLG(1), IKBKB(2), IL1A(1), IL1B(3), IL1R1(4), IL1RAP(2), IL3(2), IL3RA(4), IRAK1(3), IRAK2(3), IRAK3(9), IRAK4(2), NFKB1(2), NFKB2(3), NFKBIA(3), NTRK1(3), PIK3CB(7), PIK3CD(3), PIK3CG(12), PIK3R2(4), PIK3R3(2), PIK3R5(4), PPP3CA(1), PPP3CB(1), PPP3CC(1), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), RELA(1), RIPK1(4), TNF(1), TNFRSF10C(1), TNFRSF10D(1), TNFRSF1A(1), TNFSF10(2), TRADD(1), TRAF2(2)	94237792	151	108	150	53	39	25	19	40	28	0	0.455	1.000	1.000
449	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ADCY4(6), ADCY6(2), ADCY8(3), CACNA1A(5), CACNA1B(15), GNAS(4), GNAT3(5), GNB1(1), GNB3(1), GRM4(6), ITPR3(18), KCNB1(5), PDE1A(3), PLCB2(7), PRKACG(1), PRKX(1), SCNN1A(1), SCNN1B(6), SCNN1G(6), TAS1R1(2), TAS1R2(5), TAS1R3(1), TAS2R1(5), TAS2R10(3), TAS2R13(1), TAS2R16(5), TAS2R3(1), TAS2R38(1), TAS2R39(1), TAS2R4(2), TAS2R40(2), TAS2R41(5), TAS2R42(1), TAS2R46(1), TAS2R5(2), TAS2R60(1), TAS2R7(1), TAS2R9(4), TRPM5(3)	68098698	143	108	142	55	61	21	15	28	18	0	0.410	1.000	1.000
450	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	62	APAF1(3), ATM(12), ATR(10), BAI1(5), BAX(1), CASP8(2), CASP9(1), CCNB1(2), CCNB2(1), CCNB3(6), CCND1(4), CCND2(2), CCND3(1), CCNE1(2), CCNE2(2), CCNG1(2), CCNG2(2), CDK2(1), CDK4(1), CDK6(1), CDKN1A(2), CDKN2A(6), CHEK1(6), CHEK2(3), CYCS(2), DDB2(3), EI24(4), FAS(1), GADD45B(1), GTSE1(5), IGF1(3), MDM2(5), MDM4(2), PPM1D(4), RCHY1(1), RFWD2(4), RPRM(1), RRM2(1), RRM2B(1), SERPINB5(2), SERPINE1(4), SESN1(2), SESN2(1), SESN3(2), SFN(3), SIAH1(3), STEAP3(2), THBS1(6), TP53I3(1), TSC2(6), ZMAT3(3)	75862476	151	106	149	40	28	23	27	42	31	0	0.0505	1.000	1.000
451	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	58	AKT1(2), BLNK(2), BTK(4), CARD11(8), CD19(2), CD22(9), CD72(3), CD79A(1), CD81(2), CHUK(1), CR2(9), FOS(2), GSK3B(1), IFITM1(2), IKBKB(2), INPP5D(5), LILRB3(3), LYN(2), MALT1(4), NFAT5(4), NFATC1(2), NFATC2(7), NFATC3(3), NFATC4(5), NFKB1(2), NFKB2(3), NFKBIA(3), NFKBIE(3), PIK3CB(7), PIK3CD(3), PIK3CG(12), PIK3R2(4), PIK3R3(2), PIK3R5(4), PLCG2(12), PPP3CA(1), PPP3CB(1), PPP3CC(1), PTPN6(1), RAC1(1), RAC2(1), RASGRP3(2), VAV1(9), VAV2(4), VAV3(3)	83190287	164	105	164	66	60	36	8	34	25	1	0.350	1.000	1.000
452	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	61	AKT1(2), CDK2(1), CDKN1B(4), CDKN2A(6), CREB1(2), ERBB4(5), GSK3B(1), IFI27(1), IGF1(3), INPPL1(8), IRS1(8), IRS2(1), IRS4(8), MET(13), PAK1(3), PAK2(2), PAK3(4), PAK4(3), PAK6(3), PAK7(5), PARD3(3), PARD6A(1), PDK1(2), PIK3CD(3), PPP1R13B(2), PREX1(10), PTK2(2), PTPN1(1), RPS6KA1(5), RPS6KA2(6), RPS6KA3(4), RPS6KB1(2), SFN(3), SHC1(1), SLC2A4(2), SOS1(7), SOS2(5), TSC1(2), TSC2(6), YWHAB(2), YWHAE(3), YWHAG(1), YWHAH(2), YWHAQ(1), YWHAZ(1)	88491822	160	99	158	37	34	20	29	44	33	0	0.00777	1.000	1.000
453	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	AICDA(4), CAD(8), CANT1(5), CDA(3), CTPS2(2), DCK(2), DCTD(1), DHODH(2), DPYD(6), DPYS(5), DTYMK(1), ENTPD1(4), ENTPD5(1), ENTPD6(2), ENTPD8(1), NME7(2), NT5C(3), NT5C1A(1), NT5C1B(7), NT5C2(1), NT5E(3), NT5M(1), NUDT2(1), PNPT1(1), POLA1(3), POLA2(2), POLD1(3), POLD2(2), POLD3(2), POLD4(1), POLE(8), POLE2(1), POLR1A(7), POLR1B(3), POLR2A(9), POLR2B(4), POLR2C(2), POLR2G(1), POLR3A(7), POLR3B(3), POLR3G(1), POLR3GL(1), POLR3K(1), PRIM1(2), PRIM2(1), RRM1(3), RRM2(1), RRM2B(1), TK2(3), TXNRD1(1), TXNRD2(5), UCK1(4), UMPS(1), UPP1(3), UPP2(3), UPRT(2)	96611323	158	98	157	49	34	28	23	48	25	0	0.187	1.000	1.000
454	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACAA1(1), ACADL(1), ACADM(2), ACOX1(2), ACOX2(4), ACOX3(3), ACSL1(4), ACSL3(3), ACSL4(6), ACSL6(3), ANGPTL4(1), APOA1(1), APOA5(1), AQP7(4), CD36(5), CPT1A(2), CPT1C(2), CPT2(2), CYP27A1(2), CYP4A11(5), CYP4A22(2), CYP7A1(3), CYP8B1(3), DBI(1), EHHADH(2), FABP1(1), FABP4(1), FABP6(2), FABP7(1), FADS2(2), GK(1), GK2(5), HMGCS2(3), ILK(1), LPL(2), ME1(2), MMP1(3), NR1H3(5), OLR1(2), PCK1(6), PLTP(1), PPARA(4), PPARG(3), RXRA(4), RXRG(3), SCD(1), SCP2(1), SLC27A1(3), SLC27A2(8), SLC27A4(1), SLC27A5(4), SLC27A6(4), SORBS1(3), UBC(7)	77965329	149	98	146	52	46	28	17	40	18	0	0.197	1.000	1.000
455	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	41	APH1A(2), CREBBP(13), CTBP1(5), CTBP2(4), DLL1(1), DLL3(1), DTX1(4), DTX2(1), DTX3L(2), DTX4(4), DVL1(1), DVL2(3), DVL3(3), EP300(6), HDAC2(7), HES1(1), JAG1(7), JAG2(5), LFNG(3), MAML1(6), MAML2(2), MAML3(4), MFNG(1), NCOR2(10), NCSTN(5), NOTCH2(16), NOTCH3(7), NOTCH4(10), NUMB(1), NUMBL(2), PSEN1(1), RBPJL(5), SNW1(2)	76715028	145	98	144	52	40	22	18	28	36	1	0.502	1.000	1.000
456	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	61	ATM(12), CCNA1(3), CCNB1(2), CCND1(4), CCND2(2), CCND3(1), CCNE1(2), CCNE2(2), CCNG2(2), CCNH(2), CDC25A(1), CDK2(1), CDK4(1), CDK7(1), CDKN1A(2), CDKN1B(4), CDKN2A(6), CDKN2B(2), CREB3L1(2), CREB3L3(3), CREB3L4(1), E2F1(1), E2F2(1), E2F3(1), E2F4(1), E2F5(1), E2F6(1), GBA2(1), MCM2(2), MCM3(3), MCM4(5), MCM5(3), MCM6(6), MCM7(6), MDM2(5), MYT1(7), NACA(6), POLA2(2), POLE(8), POLE2(1), PRIM1(2), RBL1(6), RPA1(3), RPA2(1), TFDP1(1), TFDP2(1), TNXB(14), WEE1(2)	88534132	147	95	146	43	26	18	21	43	39	0	0.212	1.000	1.000
457	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	53	AKR1C4(2), AKR1D1(1), ARSD(3), ARSE(6), CARM1(1), CYP11B1(2), CYP11B2(3), CYP19A1(3), HSD11B1(2), HSD17B3(1), HSD17B7(2), HSD17B8(1), HSD3B1(2), HSD3B2(1), LCMT1(3), LCMT2(2), METTL2B(3), METTL6(2), PRMT2(2), PRMT5(4), PRMT6(1), PRMT7(1), PRMT8(5), SRD5A1(2), STS(2), SULT2A1(2), SULT2B1(3), UGT1A1(5), UGT1A10(2), UGT1A3(3), UGT1A4(1), UGT1A5(3), UGT1A6(4), UGT1A7(3), UGT1A9(2), UGT2A1(9), UGT2B10(4), UGT2B11(5), UGT2B15(3), UGT2B17(2), UGT2B28(8), UGT2B4(10), UGT2B7(4), WBSCR22(2)	58629425	132	95	129	46	38	19	21	40	14	0	0.255	1.000	1.000
458	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	54	BMP2(1), BMP4(3), BMP5(8), BMP6(3), BTRC(2), CSNK1A1(2), CSNK1A1L(2), CSNK1D(2), CSNK1E(1), CSNK1G1(2), CSNK1G2(2), CSNK1G3(1), DHH(1), FBXW11(1), GLI2(7), GLI3(8), GSK3B(1), HHIP(3), IHH(4), LRP2(37), PRKACG(1), PRKX(1), PTCH1(3), PTCH2(2), RAB23(2), SHH(3), SMO(3), STK36(2), SUFU(4), WNT1(1), WNT10A(2), WNT11(5), WNT16(2), WNT2B(2), WNT3(1), WNT3A(1), WNT5B(2), WNT7A(2), WNT8A(2), WNT8B(1), WNT9A(2), WNT9B(2), ZIC2(1)	69140689	138	95	137	43	54	20	19	24	21	0	0.100	1.000	1.000
459	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	41	ACTR2(2), ACTR3(1), AKT1(2), ANGPTL2(3), ARHGAP1(1), ARHGAP4(4), ARHGEF11(4), BTK(4), CFL1(1), CFL2(2), GDI1(4), GDI2(1), INPPL1(8), ITPR1(9), ITPR2(16), ITPR3(18), LIMK1(4), MYLK(7), MYLK2(1), PAK1(3), PAK2(2), PAK3(4), PAK4(3), PAK6(3), PAK7(5), PDK1(2), PIK3CD(3), PIK3CG(12), PITX2(7), PPP1R13B(2), RHO(1), ROCK1(4), ROCK2(5), RPS4X(3), SAG(2), WASF1(1), WASL(2)	78370066	156	94	154	47	49	33	23	31	19	1	0.0372	1.000	1.000
460	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	31	AKT1(2), BCR(3), BTK(4), CD19(2), CDKN2A(6), FLOT1(1), FLOT2(3), ITPR1(9), ITPR2(16), ITPR3(18), LYN(2), NR0B2(1), PDK1(2), PHF11(1), PITX2(7), PLCG2(12), PPP1R13B(2), PREX1(10), PTPRC(9), RPS6KA1(5), RPS6KA2(6), RPS6KA3(4), RPS6KB1(2), SAG(2), TEC(4), VAV1(9)	62362493	142	94	141	45	46	25	18	33	19	1	0.0689	1.000	1.000
461	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	63	ADAM10(4), ATP6AP1(3), ATP6V0A2(1), ATP6V0A4(3), ATP6V0C(1), ATP6V0D1(2), ATP6V0D2(3), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(1), ATP6V1E2(2), ATP6V1G1(1), ATP6V1G3(2), ATP6V1H(1), CCL5(1), CHUK(1), CSK(2), CXCL1(1), F11R(2), GIT1(2), HBEGF(1), IKBKB(2), JAM2(4), JAM3(2), LYN(2), MAPK10(1), MAPK12(2), MAPK13(2), MAPK8(2), MAPK9(1), MET(13), NFKB1(2), NFKB2(3), NFKBIA(3), NOD1(3), PAK1(3), PLCG1(12), PLCG2(12), PTPRZ1(15), RAC1(1), RELA(1), SRC(2), TCIRG1(2), TJP1(8)	79130380	140	93	137	41	34	23	22	30	30	1	0.0760	1.000	1.000
462	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	AANAT(2), ACAT2(1), ACMSD(2), ALDH1A1(2), ALDH1A2(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), AOC2(1), AOX1(9), ASMT(2), CAT(3), CYP19A1(3), CYP1A2(4), CYP2A13(2), CYP2A7(1), CYP2B6(6), CYP2C18(4), CYP2C19(5), CYP2C8(4), CYP2C9(3), CYP2D6(2), CYP2E1(2), CYP2F1(1), CYP3A4(5), CYP3A5(4), CYP3A7(3), CYP4B1(5), CYP51A1(2), DDC(6), ECHS1(3), EHHADH(2), GCDH(1), HADHA(3), KMO(3), KYNU(2), MAOA(3), MAOB(2), SDS(1), TDO2(2), TPH1(6), WARS(1), WARS2(2)	65596693	133	93	130	44	58	16	10	31	18	0	0.169	1.000	1.000
463	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(1), ACSS2(4), ACYP1(1), ADH1A(3), ADH1B(4), ADH5(1), ADH6(3), ADH7(2), ADHFE1(2), AKR1A1(3), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3B2(3), ALDH7A1(2), ALDOA(1), ALDOB(2), BPGM(2), DLD(3), ENO1(2), ENO2(2), ENO3(3), FBP1(3), FBP2(2), G6PC(8), G6PC2(1), GALM(1), GAPDH(1), GAPDHS(2), GCK(2), GPI(2), HK1(4), HK2(5), HK3(5), LDHA(1), LDHAL6A(1), LDHAL6B(2), LDHB(2), LDHC(1), PDHA1(6), PDHA2(7), PDHB(1), PFKL(6), PFKP(1), PGAM2(1), PGAM4(2), PGK1(3), PGK2(1), PGM1(1), PGM3(1), PKLR(3), TPI1(1)	69332770	137	90	135	38	54	25	10	33	15	0	0.00994	1.000	1.000
464	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	40	ALAD(2), ALAS1(2), ALAS2(1), BLVRA(2), COX10(5), COX15(1), CP(7), EARS2(1), EPRS(5), FECH(2), FTH1(3), FTMT(4), GUSB(3), HCCS(5), HMBS(1), HMOX1(1), MMAB(3), PPOX(2), UGT1A1(5), UGT1A10(2), UGT1A3(3), UGT1A4(1), UGT1A5(3), UGT1A6(4), UGT1A7(3), UGT1A9(2), UGT2A1(9), UGT2B10(4), UGT2B11(5), UGT2B15(3), UGT2B17(2), UGT2B28(8), UGT2B4(10), UGT2B7(4), UROD(1), UROS(1)	49027416	120	88	118	35	35	15	21	42	7	0	0.148	1.000	1.000
465	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG1(2), ACTG2(2), ACTR2(2), ACTR3(1), AKT1(2), ANGPTL2(3), CFL1(1), CFL2(2), FLNA(18), FLNC(16), FSCN1(2), FSCN2(2), FSCN3(3), GDI1(4), GDI2(1), LIMK1(4), MYH2(25), MYLK(7), MYLK2(1), PAK1(3), PAK2(2), PAK3(4), PAK4(3), PAK6(3), PAK7(5), RHO(1), ROCK1(4), ROCK2(5), RPS4X(3), VASP(1), WASF1(1), WASL(2)	57264276	135	87	130	41	58	16	16	28	16	1	0.0327	1.000	1.000
466	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	57	BAK1(2), BAX(1), BFAR(1), BTK(4), CAD(8), CASP10(1), CASP8(2), CD7(3), CSNK1A1(2), DAXX(5), DEDD(1), DEDD2(2), DFFA(2), DIABLO(1), EPHB2(5), FAF1(4), IL1A(1), MAP3K1(10), MAP3K5(4), MAPK1(4), MAPK10(1), MAPK8(2), MAPK8IP1(3), MAPK8IP2(4), MAPK8IP3(7), MAPK9(1), MET(13), NFAT5(4), NFKB1(2), NFKB2(3), NFKBIA(3), NFKBIE(3), NR0B2(1), PTPN13(4), RALBP1(3), RIPK1(4), ROCK1(4), SMPD1(2), TNFRSF6B(1), TPX2(7), TRAF2(2)	82893117	137	87	135	35	38	27	25	23	24	0	0.0126	1.000	1.000
467	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	51	ACTG1(2), APAF1(3), ARHGDIB(1), BAG4(1), BCL2(2), BIRC2(3), BIRC3(1), CASP2(1), CASP8(2), CASP9(1), CFLAR(1), CHUK(1), CRADD(2), CYCS(2), DAXX(5), DFFA(2), GSN(2), LMNA(2), LMNB2(3), MAP3K1(10), MAP3K5(4), MAPK8(2), MDM2(5), NFKB1(2), NFKBIA(3), NUMA1(11), PAK2(2), PRKCD(3), PRKDC(14), PSEN1(1), PTK2(2), RASA1(4), RELA(1), RIPK1(4), SPTAN1(8), TNF(1), TNFRSF1A(1), TNFRSF1B(3), TRADD(1), TRAF1(1), TRAF2(2)	80556302	122	86	119	37	31	21	19	33	17	1	0.162	1.000	1.000
468	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(2), ALPP(7), ALPPL2(6), ASCC3(7), ATP13A2(3), DDX18(1), DDX19A(2), DDX23(3), DDX4(5), DDX41(5), DDX47(2), DDX51(3), DDX52(2), DDX54(2), DDX55(1), DDX56(4), DHFR(1), DHX58(2), ENTPD7(2), EP400(9), ERCC2(3), ERCC3(2), FPGS(2), GGH(1), IFIH1(4), MOV10L1(7), QDPR(2), RAD54B(5), RAD54L(6), RUVBL2(4), SETX(5), SKIV2L2(3), SMARCA2(5), SMARCA5(3), SPR(1)	74849278	122	85	120	42	40	21	14	27	20	0	0.379	1.000	1.000
469	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AADAT(1), AANAT(2), ACAT2(1), ACMSD(2), AFMID(1), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH7A1(2), AOC2(1), AOX1(9), ASMT(2), CARM1(1), CAT(3), CYP1A2(4), CYP1B1(2), DDC(6), ECHS1(3), EHHADH(2), GCDH(1), HADHA(3), HSD17B4(3), KMO(3), KYNU(2), LCMT1(3), LCMT2(2), LNX1(4), MAOA(3), MAOB(2), METTL2B(3), METTL6(2), NFX1(3), OGDH(1), OGDHL(7), PRMT2(2), PRMT5(4), PRMT6(1), PRMT7(1), PRMT8(5), TDO2(2), TPH1(6), TPH2(3), WARS(1), WARS2(2), WBSCR22(2)	72207626	129	82	126	45	47	15	13	34	20	0	0.304	1.000	1.000
470	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(3), ADH1B(4), ADH5(1), ADH6(3), ADH7(2), ADHFE1(2), AGK(1), AGPAT1(2), AGPAT2(2), AGPAT3(1), AGPAT6(2), AKR1A1(3), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH7A1(2), CEL(4), DAK(2), DGAT1(2), DGKA(4), DGKB(3), DGKD(8), DGKE(3), DGKG(4), DGKH(4), DGKI(2), DGKQ(3), DGKZ(3), GK(1), GK2(5), GLA(2), GLB1(2), GPAM(1), LCT(13), LIPA(2), LIPC(1), LIPF(1), LIPG(4), LPL(2), MGLL(1), PNLIP(3), PNLIPRP1(4), PNPLA3(1), PPAP2A(2), PPAP2C(1)	69987295	132	80	131	34	49	17	16	37	13	0	0.0123	1.000	1.000
471	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ADH1A(3), ADH1B(4), ADH6(3), ADH7(2), ADHFE1(2), AKR1A1(3), ALDH1A1(2), ALDH1A2(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3B2(3), ALDOA(1), ALDOB(2), BPGM(2), DLD(3), ENO1(2), ENO2(2), ENO3(3), FBP1(3), FBP2(2), G6PC(8), GAPDH(1), GCK(2), GPI(2), HK1(4), HK2(5), HK3(5), LDHA(1), LDHB(2), LDHC(1), PDHA1(6), PDHA2(7), PDHB(1), PFKP(1), PGK1(3), PGM1(1), PGM3(1), PKLR(3), TPI1(1)	58183851	116	79	114	35	46	25	8	26	11	0	0.0387	1.000	1.000
472	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ADH1A(3), ADH1B(4), ADH6(3), ADH7(2), ADHFE1(2), AKR1A1(3), ALDH1A1(2), ALDH1A2(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH3B2(3), ALDOA(1), ALDOB(2), BPGM(2), DLD(3), ENO1(2), ENO2(2), ENO3(3), FBP1(3), FBP2(2), G6PC(8), GAPDH(1), GCK(2), GPI(2), HK1(4), HK2(5), HK3(5), LDHA(1), LDHB(2), LDHC(1), PDHA1(6), PDHA2(7), PDHB(1), PFKP(1), PGK1(3), PGM1(1), PGM3(1), PKLR(3), TPI1(1)	58183851	116	79	114	35	46	25	8	26	11	0	0.0387	1.000	1.000
473	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	22	INPP1(1), INPP4A(1), INPP4B(5), INPP5A(1), INPPL1(8), MIOX(1), OCRL(7), PIK3C2A(5), PIK3C2B(3), PIK3C2G(10), PIK3CB(7), PIK3CG(12), PLCB1(4), PLCB2(7), PLCB3(4), PLCB4(4), PLCD1(4), PLCG1(12), PLCG2(12)	50864429	108	79	106	43	32	18	12	30	16	0	0.717	1.000	1.000
474	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	65	APAF1(3), BAK1(2), BAX(1), BCL2(2), BCL2L11(1), BIRC2(3), BIRC3(1), CASP1(7), CASP10(1), CASP2(1), CASP4(1), CASP8(2), CASP9(1), CHUK(1), CYCS(2), DFFA(2), FAS(1), FASLG(1), GZMB(3), HELLS(3), IKBKB(2), IRF1(5), IRF2(2), IRF3(1), IRF4(4), IRF5(2), IRF6(4), IRF7(4), MAP3K1(10), MAPK10(1), MDM2(5), NFKB1(2), NFKBIA(3), NFKBIE(3), PLEKHG5(4), PRF1(3), RELA(1), RIPK1(4), TNF(1), TNFRSF1A(1), TNFRSF1B(3), TNFRSF21(2), TNFRSF25(2), TNFSF10(2), TRADD(1), TRAF1(1), TRAF2(2), TRAF3(2)	67339548	116	78	114	40	39	21	9	28	19	0	0.286	1.000	1.000
475	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(1), ALOX12(1), ALOX12B(2), ALOX15(2), ALOX15B(1), ALOX5(3), CBR1(2), CBR3(1), CYP2B6(6), CYP2C18(4), CYP2C19(5), CYP2C8(4), CYP2C9(3), CYP2E1(2), CYP2U1(2), CYP4A11(5), CYP4A22(2), CYP4F2(3), CYP4F3(7), DHRS4(1), EPHX2(2), GGT1(3), GPX2(2), GPX5(1), GPX6(1), LTA4H(4), PLA2G12B(1), PLA2G2D(1), PLA2G2F(1), PLA2G3(5), PLA2G4A(7), PLA2G5(1), PLA2G6(3), PTGES(1), PTGES2(1), PTGIS(2), PTGS1(3), PTGS2(3), TBXAS1(3)	46411939	102	78	101	35	36	15	9	25	17	0	0.243	1.000	1.000
476	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	41	BCL2(2), CHUK(1), DAXX(5), EGF(10), ETS1(6), FOS(2), HOXA7(2), IKBKB(2), MAP2K1(1), MAP2K3(6), MAP3K1(10), MAP3K5(4), MAPK1(4), MAPK13(2), MAPK3(2), MAPK8(2), NFKB1(2), NFKBIA(3), PPP2CA(4), PRKCA(6), PRKCD(3), PRKCE(1), PRKCG(4), PRKCH(3), PRKCQ(4), RAF1(2), RELA(1), RIPK1(4), SP1(1), TNF(1), TNFRSF1A(1), TNFRSF1B(3), TRAF2(2)	55401150	106	78	102	34	32	21	15	18	17	3	0.106	1.000	1.000
477	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	30	ACTR2(2), ACTR3(1), AKT1(2), ANGPTL2(3), DAG1(3), DGKA(4), GCA(1), ITGA9(2), ITPR1(9), ITPR2(16), ITPR3(18), MAP2K1(1), MAPK1(4), MAPK3(2), NR1I3(1), PAK1(3), PDE3A(5), PDE3B(3), PI3(2), PIK3C2G(10), PIK3CD(3), PSME1(3), RIPK3(2), RPS4X(3), SGCB(1), VASP(1)	53694696	105	78	103	38	29	16	20	19	19	2	0.312	1.000	1.000
478	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	55	ADH1A(3), ADH1B(4), ADH5(1), ADH6(3), ADH7(2), ADHFE1(2), ALDH1A3(5), ALDH3A1(6), ALDH3B2(3), AOC2(1), AOX1(9), CARM1(1), DBH(4), DCT(1), DDC(6), ECH1(1), ESCO1(2), ESCO2(2), FAH(2), GOT1(2), GOT2(1), GSTZ1(3), HGD(5), HPD(1), LCMT1(3), LCMT2(2), MAOA(3), MAOB(2), METTL2B(3), METTL6(2), PNPLA3(1), PRMT2(2), PRMT5(4), PRMT6(1), PRMT7(1), PRMT8(5), SH3GLB1(3), TAT(3), TH(3), TPO(10), TYR(5), WBSCR22(2)	69594504	125	77	122	38	47	16	13	35	14	0	0.0735	1.000	1.000
479	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	47	ACOX1(2), APOA1(1), CD36(5), CITED2(1), CREBBP(13), DUSP1(1), EHHADH(2), EP300(6), FABP1(1), HSD17B4(3), INS(1), LPL(2), MAPK1(4), MAPK3(2), ME1(2), NCOA1(3), NCOR1(10), NCOR2(10), NFKBIA(3), NR0B2(1), NR1H3(5), NR2F1(1), NRIP1(4), PDGFA(1), PPARA(4), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), PRKCA(6), PTGS2(3), RELA(1), RXRA(4), SP1(1), STAT5A(1), STAT5B(2), TNF(1)	68872210	112	75	110	40	31	17	11	27	23	3	0.411	1.000	1.000
480	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	ACHE(2), AGPAT1(2), AGPAT2(2), AGPAT3(1), AGPAT6(2), CDS2(2), CHAT(6), CHKB(1), CRLS1(1), DGKA(4), DGKB(3), DGKD(8), DGKE(3), DGKG(4), DGKH(4), DGKI(2), DGKQ(3), DGKZ(3), ESCO1(2), ESCO2(2), ETNK1(1), ETNK2(2), GNPAT(2), GPAM(1), GPD2(2), LCAT(1), LYPLA1(1), LYPLA2(1), PCYT1A(2), PCYT1B(2), PHOSPHO1(1), PISD(2), PLA2G12B(1), PLA2G2D(1), PLA2G2F(1), PLA2G3(5), PLA2G4A(7), PLA2G5(1), PLA2G6(3), PLD1(8), PNPLA3(1), PPAP2A(2), PPAP2C(1), PTDSS1(5), SH3GLB1(3)	78189923	114	74	113	26	39	25	10	27	13	0	0.00340	1.000	1.000
481	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	AKT1(2), APC(3), ASAH1(2), CAV3(1), DAG1(3), DLG4(5), EPHB2(5), GNAI1(4), ITPR1(9), ITPR2(16), ITPR3(18), KCNJ3(2), KCNJ5(5), KCNJ9(1), MAPK1(4), PITX2(7), PTX3(2), RAC1(1), RHO(1), RYR1(16)	54711105	107	74	107	32	35	18	21	18	14	1	0.0447	1.000	1.000
482	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	CAD(8), CANT1(5), CDA(3), CTPS2(2), DCK(2), DCTD(1), DHODH(2), DPYD(6), DPYS(5), DTYMK(1), ENTPD1(4), NT5C(3), NT5E(3), NT5M(1), NUDT2(1), POLB(3), POLD1(3), POLD2(2), POLE(8), POLG(1), POLL(2), POLQ(8), POLR1B(3), POLR2A(9), POLR2B(4), POLR2C(2), POLR2G(1), POLRMT(3), RRM1(3), RRM2(1), TK2(3), TXNRD1(1), UCK1(4), UMPS(1), UPP1(3)	68385362	112	73	111	38	23	21	14	39	15	0	0.484	1.000	1.000
483	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	38	AKT1(2), ASAH1(2), ATF1(1), CREB1(2), CREBBP(13), CRKL(2), DAG1(3), EGR1(5), EGR2(3), EGR3(2), ELK1(5), FRS2(1), MAP1B(10), MAPK1(4), MAPK10(1), MAPK3(2), MAPK8(2), MAPK8IP1(3), MAPK8IP2(4), MAPK8IP3(7), MAPK9(1), NTRK1(3), OPN1LW(1), PIK3C2G(10), PIK3CD(3), RPS6KA3(4), SHC1(1), SRC(2), TERF2IP(1), TH(3)	53741197	103	73	102	30	24	15	19	21	23	1	0.0798	1.000	1.000
484	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	57	APC(3), AXIN1(4), CCND1(4), CCND2(2), CCND3(1), CSNK1E(1), CTNNB1(3), DVL1(1), DVL2(3), DVL3(3), FZD1(3), FZD10(5), FZD2(1), FZD5(1), FZD6(2), FZD7(2), FZD8(2), FZD9(4), GSK3B(1), LDLR(3), MAPK10(1), MAPK9(1), PAFAH1B1(4), PPP2R5C(1), PPP2R5E(3), PRKCA(6), PRKCD(3), PRKCE(1), PRKCG(4), PRKCH(3), PRKCI(2), PRKCQ(4), PRKD1(1), RAC1(1), SFRP4(1), WNT1(1), WNT10A(2), WNT11(5), WNT16(2), WNT2B(2), WNT3(1), WNT5B(2), WNT7A(2)	70778222	102	73	101	34	33	11	16	18	22	2	0.239	1.000	1.000
485	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ABL1(6), ACTB(2), ACTG1(2), ARHGEF2(5), CD14(1), CDH1(4), CLDN1(1), CTNNB1(3), CTTN(3), EZR(4), FYN(2), HCLS1(4), ITGB1(3), KRT18(3), LY96(2), NCL(3), OCLN(3), PRKCA(6), ROCK1(4), ROCK2(5), TLR4(2), TLR5(4), TUBA1A(4), TUBA1B(1), TUBA3C(10), TUBA3D(2), TUBA4A(2), TUBA8(2), TUBB(1), TUBB6(3), TUBB8(3), WAS(3), WASL(2), YWHAQ(1), YWHAZ(1)	61741612	107	72	107	39	41	18	16	19	12	1	0.274	1.000	1.000
486	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ABL1(6), ACTB(2), ACTG1(2), ARHGEF2(5), CD14(1), CDH1(4), CLDN1(1), CTNNB1(3), CTTN(3), EZR(4), FYN(2), HCLS1(4), ITGB1(3), KRT18(3), LY96(2), NCL(3), OCLN(3), PRKCA(6), ROCK1(4), ROCK2(5), TLR4(2), TLR5(4), TUBA1A(4), TUBA1B(1), TUBA3C(10), TUBA3D(2), TUBA4A(2), TUBA8(2), TUBB(1), TUBB6(3), TUBB8(3), WAS(3), WASL(2), YWHAQ(1), YWHAZ(1)	61741612	107	72	107	39	41	18	16	19	12	1	0.274	1.000	1.000
487	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CD14(1), CHUK(1), ELK1(5), FOS(2), IKBKB(2), IRAK1(3), LY96(2), MAP2K3(6), MAP3K1(10), MAP3K7(3), MAPK8(2), NFKB1(2), NFKBIA(3), PPARA(4), RELA(1), TLR10(7), TLR2(5), TLR3(6), TLR4(2), TLR6(8), TLR7(10), TLR9(5), TOLLIP(1), TRAF6(1)	43569217	92	71	87	31	29	18	12	23	10	0	0.242	1.000	1.000
488	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(2), ACTG2(2), ADCY3(5), ADCY9(11), AK1(1), ARF1(1), ARF6(1), ARL4D(1), ATP6V0A2(1), ATP6V0A4(3), ATP6V0C(1), ATP6V0D1(2), ATP6V0D2(3), ATP6V1A(2), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(1), ATP6V1E2(2), ATP6V1G1(1), ATP6V1G3(2), ATP6V1H(1), ERO1L(1), GNAS(4), PDIA4(3), PLCG1(12), PLCG2(12), PRKCA(6), SEC61A1(1), TRIM23(3)	44095823	89	70	87	32	33	18	9	16	12	1	0.355	1.000	1.000
489	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ALDH1A1(2), ALDH1A2(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH4A1(2), AMD1(2), AOC2(1), ARG2(2), ASL(2), CKB(1), CKM(3), CKMT1A(2), CKMT1B(4), CKMT2(1), CPS1(8), DAO(3), GAMT(1), GATM(2), GLUD1(5), GOT1(2), GOT2(1), MAOA(3), MAOB(2), NOS1(11), NOS3(10), OAT(1), ODC1(3), OTC(2), P4HA1(1), P4HB(1), RARS(3), SMS(1)	52784550	100	68	100	37	36	18	11	22	13	0	0.335	1.000	1.000
490	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	30	AKT1(2), APC(3), AR(4), ASAH1(2), CCL13(1), CCL16(1), DAG1(3), GNA11(1), GNA15(1), GNAI1(4), ITPR1(9), ITPR2(16), ITPR3(18), KCNJ3(2), KCNJ5(5), KCNJ9(1), MAPK1(4), MAPK10(1), PHKA2(5), PIK3CD(3), PITX2(7), PTX3(2), RAF1(2), SRC(2)	54425272	99	68	99	31	26	15	26	19	11	2	0.121	1.000	1.000
491	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	92	ANK2(16), CDR1(1), DGKI(2), IL6ST(3), MRPL19(2), RPL10(5), RPL11(2), RPL13A(2), RPL15(2), RPL18A(1), RPL23(1), RPL24(1), RPL29(1), RPL32(1), RPL35(2), RPL36(1), RPL3L(1), RPL6(1), RPL7(3), RPL7A(1), RPLP0(1), RPS11(1), RPS12(2), RPS18(2), RPS19(1), RPS2(1), RPS21(1), RPS24(1), RPS3(3), RPS4X(3), RPS5(1), RPS6KA1(5), RPS6KA2(6), RPS6KA3(4), RPS6KA6(5), RPS6KB1(2), RPS6KB2(3), SLC36A2(3), TBC1D10C(2), TSPAN9(1), UBA52(1), UBC(7)	61793176	105	65	104	30	25	16	13	32	19	0	0.329	1.000	1.000
492	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	37	AKT1(2), BCR(3), BLNK(2), BTK(4), CD19(2), CSK(2), DAG1(3), EPHB2(5), LYN(2), MAP2K1(1), MAP2K2(1), MAPK1(4), NFAT5(4), NFKB1(2), NFKB2(3), NFKBIA(3), NFKBIE(3), PI3(2), PIK3CD(3), PLCG2(12), PPP1R13B(2), RAF1(2), SERPINA4(2), SHC1(1), SOS1(7), SOS2(5), VAV1(9)	58304968	91	65	91	34	28	19	12	21	11	0	0.314	1.000	1.000
493	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	37	AKT1(2), ATF2(2), DLD(3), DUSP10(2), DUSP4(1), GCK(2), IL1R1(4), MAP2K5(2), MAP3K1(10), MAP3K10(1), MAP3K12(6), MAP3K13(4), MAP3K3(2), MAP3K4(7), MAP3K5(4), MAP3K7(3), MAP3K9(6), MAPK10(1), MAPK7(6), MAPK8(2), MAPK9(1), MYEF2(3), NFATC3(3), NR2C2(3), PAPPA(6), SHC1(1), TRAF6(1), ZAK(5)	59099836	93	65	91	30	25	19	16	24	9	0	0.292	1.000	1.000
494	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(6), CARM1(1), CCND1(4), CREBBP(13), EP300(6), ERCC3(2), ESR1(3), GRIP1(9), GTF2E1(3), GTF2F1(1), HDAC2(7), HDAC3(1), HDAC4(4), HDAC5(1), HDAC6(4), NCOR2(10), NR0B1(1), NRIP1(4), PELP1(2), POLR2A(9), TBP(2)	55181999	93	63	92	32	30	13	7	22	21	0	0.434	1.000	1.000
495	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CALM1(1), CALM3(1), CAMK1(2), CAMK1G(1), ELK1(5), FPR1(1), GNA15(1), GNB1(1), MAP2K1(1), MAP2K2(1), MAP2K3(6), MAP3K1(10), MAPK1(4), MAPK3(2), NCF1(3), NCF2(6), NFATC1(2), NFATC2(7), NFATC3(3), NFATC4(5), NFKB1(2), NFKBIA(3), PAK1(3), PIK3C2G(10), PLCB1(4), PPP3CA(1), PPP3CB(1), PPP3CC(1), RAC1(1), RAF1(2), RELA(1), SYT1(3)	45743037	95	63	92	34	27	14	14	18	21	1	0.274	1.000	1.000
496	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	AGXT(2), AGXT2(2), ALAS1(2), ALAS2(1), AMT(3), AOC2(1), ATP6V0C(1), CBS(5), CHKB(1), CTH(2), DAO(3), DLD(3), DMGDH(3), GAMT(1), GARS(3), GATM(2), GCAT(2), GLDC(3), MAOA(3), MAOB(2), PISD(2), PLCB2(7), PLCG1(12), PLCG2(12), PSPH(3), SARDH(4), SARS(1), SHMT1(2), TARS(1)	50178347	89	63	87	30	28	23	5	22	11	0	0.154	1.000	1.000
497	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	112	ATP12A(7), ATP4A(6), ATP4B(2), ATP5A1(1), ATP5B(3), ATP5G2(1), ATP5I(1), ATP6AP1(3), ATP6V0A2(1), ATP6V0A4(3), ATP6V0C(1), ATP6V0D1(2), ATP6V0D2(3), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1D(1), ATP6V1E2(2), ATP6V1G1(1), ATP6V1G3(2), ATP6V1H(1), COX10(5), COX15(1), COX17(1), COX6B1(1), COX7A1(1), COX7B2(1), COX7C(1), LHPP(1), NDUFA10(4), NDUFA12(1), NDUFA3(2), NDUFA4(1), NDUFA7(1), NDUFA9(4), NDUFB11(1), NDUFB5(1), NDUFS1(2), NDUFS2(1), NDUFS3(1), NDUFS8(1), NDUFV1(2), NDUFV2(1), PPA2(1), SDHA(4), SDHC(2), TCIRG1(2), UQCRC1(4), UQCRC2(1), UQCRH(2), UQCRQ(1)	66292815	101	63	100	32	25	17	16	26	16	1	0.221	1.000	1.000
498	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	28	AGA(1), FUCA1(6), FUCA2(3), GLB1(2), GUSB(3), HEXA(1), HEXB(1), HGSNAT(3), HPSE(5), HPSE2(5), HYAL1(3), HYAL2(2), IDS(2), LCT(13), MAN2B1(7), MAN2B2(7), MAN2C1(2), MANBA(1), NAGLU(3), NEU1(2), NEU3(2), NEU4(2), SPAM1(7)	40284168	83	63	81	29	32	10	9	23	9	0	0.360	1.000	1.000
499	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(2), ARG2(2), ASL(2), ASS1(4), CKB(1), CKM(3), CKMT1A(2), CKMT1B(4), CKMT2(1), CPS1(8), DAO(3), EPRS(5), GAMT(1), GATM(2), GLUD1(5), GLUD2(4), GOT1(2), GOT2(1), LAP3(1), NOS1(11), NOS3(10), OAT(1), OTC(2), P4HA1(1), PARS2(2), PRODH(1), RARS(3), RARS2(4)	42870596	88	62	87	32	32	15	11	20	10	0	0.381	1.000	1.000
500	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	72	B2M(1), CALR(2), CANX(2), CD4(2), CD8A(1), CIITA(5), CREB1(2), CTSB(4), CTSS(1), HLA-A(1), HLA-B(1), HLA-C(1), HLA-DMA(2), HLA-DMB(5), HLA-DOA(2), HLA-DOB(2), HLA-DPB1(1), HLA-DQA1(1), HLA-DQA2(3), HLA-DRA(4), HLA-DRB1(1), HLA-DRB5(1), HLA-E(1), HLA-F(2), HSP90AA1(2), HSP90AB1(3), IFI30(1), IFNA10(2), IFNA5(1), IFNA6(1), IFNA7(1), IFNA8(1), KIR2DL3(3), KIR3DL1(3), KIR3DL2(1), KIR3DL3(1), KLRC1(3), KLRC2(1), KLRC3(4), KLRC4(1), KLRD1(1), LGMN(1), NFYA(1), NFYB(1), PDIA3(1), PSME1(3), RFX5(2), RFXANK(1), TAP1(2), TAP2(1), TAPBP(1)	54797339	92	62	91	36	21	17	12	24	18	0	0.568	1.000	1.000
501	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(1), ACAA2(3), ACADL(1), ACADM(2), ACADS(5), ACADVL(3), ACAT2(1), ACOX1(2), ACOX3(3), ACSL1(4), ACSL3(3), ACSL4(6), ACSL6(3), ADH1A(3), ADH1B(4), ADH5(1), ADH6(3), ADH7(2), ADHFE1(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH7A1(2), CPT1A(2), CPT1C(2), CPT2(2), CYP4A11(5), CYP4A22(2), ECHS1(3), EHHADH(2), GCDH(1), HADHA(3), HSD17B4(3)	58340750	95	61	93	41	27	13	8	26	21	0	0.746	1.000	1.000
502	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(2), ARHGEF11(4), BCL2(2), DLG4(5), GNA13(2), LPA(11), MAP3K1(10), MAP3K5(4), MAPK8(2), NFKB1(2), NFKB2(3), NFKBIA(3), NFKBIE(3), PDK1(2), PHKA2(5), PI3(2), PIK3CB(7), PLD1(8), PLD3(1), PTK2(2), RDX(5), ROCK1(4), ROCK2(5), SERPINA4(2), SRF(3), TBXA2R(1)	58540371	100	61	98	32	25	22	15	23	14	1	0.252	1.000	1.000
503	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ADH1A(3), ADH1B(4), ADH6(3), ADH7(2), ADHFE1(2), ALDH1A3(5), ALDH3A1(6), ALDH3B2(3), AOC2(1), AOX1(9), DBH(4), DCT(1), DDC(6), FAH(2), GOT1(2), GOT2(1), GSTZ1(3), HGD(5), HPD(1), MAOA(3), MAOB(2), TAT(3), TH(3), TPO(10), TYR(5)	37788028	89	61	86	30	40	9	8	25	7	0	0.158	1.000	1.000
504	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	59	B3GALNT1(2), B3GALT1(2), B3GALT2(1), B3GALT5(2), B3GNT2(1), B3GNT3(4), B3GNT4(2), B3GNT5(4), B4GALNT1(3), B4GALT2(1), B4GALT6(2), FUT1(1), FUT2(2), FUT3(2), FUT4(1), FUT5(6), FUT6(3), FUT7(1), GBGT1(2), GCNT2(1), PIGA(3), PIGB(1), PIGC(1), PIGF(1), PIGG(2), PIGN(2), PIGO(5), PIGQ(3), PIGS(2), PIGT(1), PIGU(2), PIGX(1), PIGZ(2), ST3GAL1(3), ST3GAL2(1), ST3GAL3(2), ST3GAL4(3), ST6GALNAC3(3), ST6GALNAC4(1), ST6GALNAC6(1), ST8SIA1(2), ST8SIA5(3), UGCG(2)	57114646	90	58	90	37	32	8	8	28	14	0	0.779	1.000	1.000
505	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(3), AKT1(2), DAG1(3), ITPR1(9), ITPR2(16), ITPR3(18), NFKB1(2), NFKB2(3), NFKBIA(3), NFKBIE(3), PDK1(2), PHKA2(5), PIK3CB(7), PITX2(7), PLD1(8), PLD3(1), VN1R1(1)	53556589	93	58	93	34	29	17	15	23	7	2	0.289	1.000	1.000
506	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(2), ACTR3(1), ARHGAP1(1), ARHGAP4(4), ARHGAP5(5), ARHGAP6(4), ARHGEF1(1), ARHGEF11(4), ARHGEF5(3), ARPC1A(1), ARPC1B(2), ARPC2(1), ARPC3(1), ARPC4(1), BAIAP2(3), CFL1(1), DIAPH1(5), GSN(2), LIMK1(4), MYL2(2), MYLK(7), OPHN1(6), PIP5K1B(3), PPP1R12B(1), ROCK1(4), SRC(2), TLN1(5), VCL(1)	54293938	77	57	76	31	18	9	10	27	13	0	0.743	1.000	1.000
507	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	23	ARNT(1), EIF2B1(1), EIF2B4(1), EIF2S2(2), EIF2S3(3), ELAVL1(1), FLT1(10), FLT4(8), KDR(14), NOS3(10), PLCG1(12), PRKCA(6), PTK2(2), PXN(1), SHC1(1)	36101300	73	57	71	30	20	12	11	18	11	1	0.631	1.000	1.000
508	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	46	AADAT(1), AASDHPPT(1), AASS(1), ACAT2(1), AKR1B10(3), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH7A1(2), DOT1L(4), ECHS1(3), EHHADH(2), EHMT1(6), EHMT2(5), GCDH(1), HADHA(3), HSD17B4(3), HSD3B7(1), NSD1(5), OGDH(1), OGDHL(7), PLOD1(3), PLOD2(2), PLOD3(1), SETD1A(4), SETD7(2), SETDB1(8), SHMT1(2), SUV39H1(2), SUV39H2(1), TMLHE(2)	68327068	93	55	93	43	35	12	9	24	13	0	0.828	1.000	1.000
509	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(3), BAX(1), BCL2(2), BCL2A1(1), BCL2L2(1), BOK(1), CASP1(7), CASP10(1), CASP2(1), CASP4(1), CASP8(2), CASP9(1), CD40(1), CD40LG(2), CRADD(2), CYCS(2), DAXX(5), DFFA(2), FAS(1), FASLG(1), IKBKE(5), MCL1(1), NFKB1(2), NFKBIA(3), NGFR(1), NR3C1(3), NTRK1(3), PTPN13(4), RIPK1(4), TFG(1), TNF(1), TNFRSF1A(1), TNFRSF1B(3), TRADD(1), TRAF1(1), TRAF2(2), TRAF3(2), TRAF6(1)	51963903	77	54	77	30	22	12	5	20	18	0	0.677	1.000	1.000
510	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(2), AKR1D1(1), ARSD(3), ARSE(6), CYP11B1(2), CYP11B2(3), HSD11B1(2), HSD17B3(1), HSD17B8(1), HSD3B1(2), HSD3B2(1), SRD5A1(2), STS(2), SULT2A1(2), UGT1A1(5), UGT1A10(2), UGT1A3(3), UGT1A4(1), UGT1A5(3), UGT1A6(4), UGT1A7(3), UGT1A9(2), UGT2B15(3), UGT2B4(10)	32607041	66	53	65	26	23	12	10	15	6	0	0.367	1.000	1.000
511	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	44	AGXT(2), AGXT2(2), AKR1B10(3), ALAS1(2), ALAS2(1), AMT(3), AOC2(1), CBS(5), CHKB(1), CTH(2), DAO(3), DLD(3), DMGDH(3), GAMT(1), GARS(3), GATM(2), GCAT(2), GLDC(3), HSD3B7(1), MAOA(3), MAOB(2), PHGDH(5), PISD(2), PSAT1(4), PSPH(3), SARDH(4), SARS(1), SARS2(2), SDS(1), SHMT1(2), TARS(1), TARS2(2)	50011212	75	52	75	24	22	21	5	19	8	0	0.138	1.000	1.000
512	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(19), C5(7), C6(4), C7(5), ICAM1(3), IL1A(1), IL6(2), ITGA4(8), ITGAL(2), ITGB1(3), ITGB2(5), SELP(4), SELPLG(3), TNF(1), VCAM1(2)	29572212	69	52	69	33	20	9	10	18	12	0	0.789	1.000	1.000
513	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(1), CDC7(2), CDK2(1), DIAPH2(5), GMNN(1), MCM10(4), MCM2(2), MCM3(3), MCM4(5), MCM5(3), MCM6(6), MCM7(6), NACA(6), POLA2(2), POLD1(3), POLD2(2), POLD3(2), POLD4(1), POLE(8), POLE2(1), PRIM1(2), RFC1(2), RFC4(4), RPA1(3), RPA2(1), RPA4(2), UBA52(1), UBC(7)	60525590	86	51	86	37	14	13	11	30	18	0	0.859	1.000	1.000
514	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	21	BCAR1(3), CXCR4(2), GNAI1(4), GNB1(1), MAP2K1(1), MAPK1(4), MAPK3(2), NFKB1(2), PIK3C2G(10), PLCG1(12), PRKCA(6), PTK2(2), PTK2B(5), PXN(1), RAF1(2), RELA(1)	28518631	58	50	56	22	17	5	13	11	10	2	0.523	1.000	1.000
515	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	19	ADCYAP1R1(5), CALCRL(1), CD97(3), CRHR2(5), ELTD1(6), EMR1(5), EMR2(6), GHRHR(3), GIPR(2), GLP1R(2), GLP2R(3), GPR64(4), LPHN1(2), LPHN2(8), LPHN3(7), SCTR(1), VIPR1(1), VIPR2(2)	30729144	66	49	65	29	19	7	13	22	5	0	0.766	1.000	1.000
516	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(3), AARS2(1), DARS(1), DARS2(2), EARS2(1), EPRS(5), FARS2(3), FARSA(1), GARS(3), HARS(4), HARS2(1), IARS(4), IARS2(3), KARS(2), LARS(4), MARS(7), MARS2(2), MTFMT(1), NARS(2), NARS2(1), PARS2(2), QARS(5), RARS(3), RARS2(4), SARS(1), SARS2(2), TARS(1), TARS2(2), VARS(4), VARS2(4), WARS(1), WARS2(2), YARS(1), YARS2(1)	64662477	84	49	84	23	13	18	11	29	13	0	0.295	1.000	1.000
517	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(3), ANAPC10(1), ANAPC2(2), ANAPC4(2), ANAPC5(4), ANAPC7(2), BTRC(2), CDC16(2), CDC20(1), CDC23(4), CDC27(5), CUL1(4), CUL2(7), CUL3(1), FBXW11(1), FBXW7(5), FZR1(4), ITCH(1), RBX1(1), SKP2(3), SMURF1(4), SMURF2(2), UBE2D4(2), UBE2E3(1), WWP1(3), WWP2(2)	48050476	69	47	69	29	16	8	13	21	11	0	0.863	1.000	1.000
518	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(2), ATF1(1), CREB1(2), DUSP1(1), DUSP10(2), EEF2K(2), EIF4E(2), ELK1(5), IL1R1(4), MAP2K3(6), MAP3K10(1), MAP3K4(7), MAP3K5(4), MAP3K7(3), MAPK1(4), MAPK12(2), MAPK13(2), MAPKAPK2(2), MAPKAPK5(2), MKNK1(2), MYEF2(3), NFKB1(2), NR2C2(3), SRF(3), TRAF6(1)	39767228	68	47	68	24	18	10	15	15	10	0	0.406	1.000	1.000
519	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(7), APOA1(1), APOA4(3), APOE(2), CETP(3), CYP7A1(3), DGAT1(2), LCAT(1), LDLR(3), LIPC(1), LPL(2), LRP1(29), SCARB1(1), SOAT1(5)	32627171	63	47	63	26	15	10	5	20	13	0	0.747	1.000	1.000
520	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(6), GABBR1(2), GPRC5C(1), GPRC5D(2), GRM1(6), GRM2(4), GRM3(16), GRM4(6), GRM5(6), GRM7(5), GRM8(7)	25019189	61	46	59	41	33	5	3	15	5	0	0.985	1.000	1.000
521	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QA(2), C1QB(1), C1R(2), C1S(5), C2(7), C3(19), C5(7), C6(4), C7(5), C8A(4), C8B(7), C9(2), MASP1(2)	24835879	67	45	67	28	25	10	4	19	9	0	0.664	1.000	1.000
522	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QA(2), C1QB(1), C1R(2), C1S(5), C2(7), C3(19), C5(7), C6(4), C7(5), C8A(4), C9(2), MASP1(2), MASP2(1), MBL2(4)	25424939	65	44	65	25	24	7	5	19	10	0	0.576	1.000	1.000
523	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(1), ALG10B(3), ALG12(2), ALG13(4), ALG14(1), ALG3(4), ALG5(3), ALG6(3), B4GALT2(1), DAD1(1), DHDDS(1), DOLPP1(1), DPAGT1(2), DPM1(3), FUT8(7), GANAB(4), MAN1A1(3), MAN1A2(1), MAN1B1(1), MAN1C1(2), MAN2A1(4), MGAT1(3), MGAT2(3), MGAT3(3), MGAT4A(1), MGAT5(2), MGAT5B(2), RPN1(1), RPN2(1), ST6GAL1(2), STT3B(2)	50526941	72	44	72	23	17	19	10	10	16	0	0.234	1.000	1.000
524	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(3), AXIN1(4), CREBBP(13), CTNNB1(3), DVL1(1), EP300(6), FZD1(3), GSK3B(1), LDB1(2), LEF1(1), PITX2(7), TRRAP(19), WNT1(1)	39558146	64	44	64	25	17	9	9	16	13	0	0.650	1.000	1.000
525	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B10(3), ALDOA(1), ALDOB(2), FBP1(3), FBP2(2), FPGT(3), GMDS(1), GMPPA(2), HK1(4), HK2(5), HK3(5), HSD3B7(1), LHPP(1), MPI(2), MTMR1(6), MTMR2(3), MTMR6(1), PFKFB1(6), PFKFB2(2), PFKFB3(2), PFKFB4(1), PFKL(6), PFKP(1), PGM2(4), PMM1(1), SORD(1), TPI1(1), TSTA3(1)	44368347	71	43	71	25	31	12	6	13	9	0	0.248	1.000	1.000
526	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(1), ACAA2(3), ACAD8(4), ACAD9(1), ADH1A(3), ADH1B(4), ADH5(1), ADH6(3), ADH7(2), ADHFE1(2), AKR1B10(3), AKR1C4(2), AKR1D1(1), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH7A1(2), BAAT(1), CEL(4), CYP27A1(2), CYP7A1(3), HSD3B7(1), LIPA(2), SLC27A5(4), SOAT1(5), SOAT2(2), SRD5A1(2)	37716038	74	43	74	32	19	11	8	29	7	0	0.813	1.000	1.000
527	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCL3(1), CCR1(1), CCR2(2), CCR3(2), CCR4(3), CCR5(1), CCR7(1), CD28(2), CD4(2), CSF2(2), CXCR4(2), IFNG(2), IFNGR1(1), IFNGR2(4), IL12B(4), IL12RB1(4), IL12RB2(4), IL18R1(4), IL4R(10), IL5(1), TGFB2(2), TGFB3(1)	23859462	56	43	55	23	20	3	9	16	8	0	0.574	1.000	1.000
528	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	17	CBL(2), EGF(10), MAP2K1(1), MAPK1(4), MAPK3(2), PTPRB(10), RAF1(2), RASA1(4), SHC1(1), SOS1(7), SPRY1(1), SPRY2(3), SPRY3(3), SPRY4(3), SRC(2)	26591783	55	43	55	19	14	3	7	16	14	1	0.597	1.000	1.000
529	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	32	AKT1(2), BCL2(2), CBL(2), CFLAR(1), CRKL(2), E2F1(1), FOS(2), IL2RB(2), IRS1(8), JAK1(3), JAK3(5), MAPK1(4), MAPK3(2), PTPN6(1), RAF1(2), RPS6KB1(2), SHC1(1), SOCS1(1), SOS1(7), STAT5A(1), STAT5B(2)	38667332	53	42	53	22	11	8	7	13	13	1	0.757	1.000	1.000
530	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTN1(3), ACTN2(6), BCAR1(3), BCR(3), CAPN1(2), CAPNS1(2), CAPNS2(1), CRKL(2), CSK(2), FYN(2), ITGA1(4), ITGB1(3), MAP2K1(1), MAP2K2(1), MAPK1(4), MAPK3(2), MAPK8(2), PPP1R12B(1), PTK2(2), PXN(1), RAF1(2), ROCK1(4), SHC1(1), SOS1(7), SRC(2), TLN1(5), VCL(1), ZYX(2)	56256898	71	42	71	20	22	10	14	16	8	1	0.115	1.000	1.000
531	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QA(2), C1QB(1), C1R(2), C1S(5), C2(7), C3(19), C5(7), C6(4), C7(5), C8A(4), C9(2)	20915879	58	40	58	23	22	5	4	18	9	0	0.667	1.000	1.000
532	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	14	AGA(1), FUCA1(6), FUCA2(3), GLB1(2), HEXA(1), HEXB(1), LCT(13), MAN2B1(7), MAN2B2(7), MAN2C1(2), MANBA(1), NEU1(2), NEU3(2), NEU4(2)	23426645	50	39	50	21	16	6	6	16	6	0	0.693	1.000	1.000
533	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(6), ICAM1(3), ITGA4(8), ITGAL(2), ITGAM(7), ITGB1(3), ITGB2(5), SELE(8), SELP(4)	19036185	46	39	45	26	18	5	10	8	5	0	0.848	1.000	1.000
534	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(1), ACAA2(3), ADH1A(3), ADH1B(4), ADH6(3), ADH7(2), ADHFE1(2), AKR1C4(2), AKR1D1(1), ALDH1A1(2), ALDH1A2(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), BAAT(1), CEL(4), CYP27A1(2), CYP7A1(3), SOAT2(2), SRD5A1(2)	27706077	55	38	55	24	17	9	5	19	5	0	0.692	1.000	1.000
535	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH7A1(2), AMD1(2), AOC2(1), ARG2(2), ASL(2), ASS1(4), CPS1(8), GATM(2), MAOA(3), MAOB(2), NAGS(1), ODC1(3), OTC(2), SMS(1), SRM(2)	35166477	53	38	52	20	19	6	6	13	9	0	0.595	1.000	1.000
536	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	CHUK(1), IKBKB(2), IL1A(1), IL1R1(4), IRAK1(3), MAP3K1(10), MAP3K7(3), NFKB1(2), NFKBIA(3), RELA(1), RIPK1(4), TLR4(2), TNF(1), TNFAIP3(2), TNFRSF1A(1), TNFRSF1B(3), TRADD(1), TRAF6(1)	29078236	45	38	43	20	15	12	4	8	6	0	0.659	1.000	1.000
537	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	17	ADCY1(5), ARHGEF1(1), F2(4), F2R(2), F2RL3(3), GNA13(2), GNAI1(4), GNB1(1), MAP3K7(3), PLCB1(4), PPP1R12B(1), PRKCA(6), PTK2B(5), ROCK1(4)	26361966	45	38	45	19	14	7	6	10	7	1	0.614	1.000	1.000
538	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA1(2), ANXA2(2), ANXA3(3), ANXA5(1), ANXA6(3), CYP11A1(7), EDNRA(1), EDNRB(1), HPGD(1), HSD11B1(2), PLA2G4A(7), PRL(1), PTGER4(2), PTGFR(7), PTGIS(2), PTGS1(3), PTGS2(3), SCGB1A1(1), TBXAS1(3)	24616367	52	38	52	21	16	5	4	17	10	0	0.657	1.000	1.000
539	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	CEBPB(2), CLOCK(3), CRY1(3), DNAJA1(3), EIF4G2(1), ETV6(4), GFRA1(1), HERPUD1(2), HSPA8(3), IDI1(2), KLF9(3), MYF6(2), NCKAP1(5), NCOA4(3), NR1D2(1), PER1(6), PER2(6), PIGF(1), PPP1R3C(1), PPP2CB(1), PSMA4(1), PURA(1), SF3A3(2), TOB1(1), UGP2(1), ZFR(3)	43666030	62	37	61	21	14	11	9	21	7	0	0.542	1.000	1.000
540	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(3), POLA2(2), POLB(3), POLD1(3), POLD2(2), POLD3(2), POLD4(1), POLE(8), POLE2(1), POLG(1), POLH(1), POLI(5), POLK(2), POLL(2), POLM(3), POLQ(8), PRIM1(2), PRIM2(1), REV1(5), REV3L(8)	48468266	63	37	63	24	16	9	7	21	10	0	0.815	1.000	1.000
541	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	23	CAPN1(2), CAPNS1(2), CAPNS2(1), EGF(10), ITGA1(4), ITGB1(3), MAPK1(4), MAPK3(2), MYL2(2), MYLK(7), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1), PTK2(2), PXN(1), TLN1(5)	35871687	50	37	50	22	18	2	10	13	6	1	0.774	1.000	1.000
542	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(3), BCL2(2), BIRC2(3), BIRC3(1), CASP10(1), CASP8(2), CASP9(1), CFLAR(1), CHUK(1), CYCS(2), DFFA(2), GAS2(1), LMNA(2), NFKB1(2), NFKBIA(3), RELA(1), RIPK1(4), SPTAN1(8), TNFRSF25(2), TNFSF10(2), TRADD(1), TRAF2(2)	39867404	47	36	47	15	13	7	5	14	8	0	0.411	1.000	1.000
543	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOA(1), ALDOB(2), DERA(1), FBP1(3), FBP2(2), G6PD(3), GPI(2), H6PD(3), PFKL(6), PFKP(1), PGD(1), PGLS(1), PGM1(1), PGM3(1), PRPS1(1), PRPS1L1(3), PRPS2(5), RBKS(1), RPE(1), RPIA(1), TALDO1(2), TKT(2), TKTL1(1), TKTL2(3)	28983366	48	36	48	21	21	9	2	7	9	0	0.504	1.000	1.000
544	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	29	ACO2(4), DLD(3), FH(1), IDH3A(1), IDH3B(1), OGDH(1), PC(4), PDHA1(6), PDHA2(7), PDHB(1), PDK1(2), PDK3(3), PDK4(2), PDP2(3), SDHA(4), SDHC(2), SUCLA2(1), SUCLG1(2), SUCLG2(1)	32907613	49	36	46	20	10	12	7	13	7	0	0.568	1.000	1.000
545	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(1), AASDH(3), AASDHPPT(1), AASS(1), ACAT2(1), ALDH1A1(2), ALDH1A2(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ATP6V0C(1), DOT1L(4), ECHS1(3), EHHADH(2), EHMT1(6), EHMT2(5), GCDH(1), HADHA(3), PLOD1(3), PLOD2(2), PLOD3(1), SDS(1), SHMT1(2), TMLHE(2)	44215115	63	36	63	32	26	10	7	11	9	0	0.782	1.000	1.000
546	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	ATF1(1), CASP2(1), CHUK(1), CRADD(2), IKBKB(2), MAP2K3(6), MAP3K1(10), MAP4K2(1), MAPK8(2), NFKB1(2), NFKBIA(3), RELA(1), RIPK1(4), TANK(3), TNF(1), TNFRSF1A(1), TRADD(1), TRAF2(2)	28825844	44	36	42	20	14	11	3	8	8	0	0.732	1.000	1.000
547	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(1), ACADL(1), ACADM(2), ALDH1A1(2), ALDH1A2(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), AOC2(1), CNDP1(4), DPYD(6), DPYS(5), ECHS1(3), EHHADH(2), GAD1(3), GAD2(1), HADHA(3), MLYCD(4), SDS(1), SMS(1)	34628793	58	35	57	24	19	11	3	16	9	0	0.577	1.000	1.000
548	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	14	BCL2(2), CREBBP(13), EP300(6), FYN(2), IL7(1), IL7R(4), JAK1(3), JAK3(5), LCK(1), PTK2B(5), STAT5A(1), STAT5B(2)	28924976	45	35	45	18	10	7	5	13	10	0	0.732	1.000	1.000
549	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(2), CHUK(1), IFNG(2), IKBKB(2), MAP3K1(10), MAP3K5(4), MAP4K5(1), MAPK8(2), NFKB1(2), NFKBIA(3), RELA(1), TNFRSF9(4), TNFSF9(5), TRAF2(2)	23120215	41	34	36	16	11	8	6	4	12	0	0.585	1.000	1.000
550	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	9	EGF(10), MAP2K1(1), MAP3K1(10), NCOR2(10), RXRA(4), THRA(3), THRB(2)	17458900	40	34	36	15	12	8	2	9	9	0	0.601	1.000	1.000
551	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	15	ADAM12(1), AGT(3), AGTR2(4), EDNRA(1), EDNRB(1), EGF(10), FOS(2), NFKB1(2), PLCG1(12), PRKCA(6), RELA(1)	21291684	43	33	41	19	12	6	5	16	3	1	0.789	1.000	1.000
552	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(2), GTF2E1(3), GTF2F1(1), HDAC3(1), NCOA1(3), NCOA2(5), NCOA3(5), NCOR2(10), POLR2A(9), RXRA(4), TBP(2)	29783492	45	33	44	25	7	8	1	15	14	0	0.973	1.000	1.000
553	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM1(1), CALM3(1), CCL2(1), CCR5(1), CXCR4(2), FOS(2), MAPK8(2), PLCG1(12), PRKCA(6), PTK2B(5), SYT1(3)	16419530	36	32	34	14	8	7	8	7	5	1	0.422	1.000	1.000
554	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	22	ARSA(1), ARSD(3), ARSE(6), ASAH1(2), GAL3ST1(2), GALC(1), GLA(2), GLB1(2), LCT(13), NEU1(2), NEU3(2), NEU4(2), PPAP2A(2), PPAP2C(1), SMPD1(2), SMPD2(1), SPTLC1(3), SPTLC2(2), UGCG(2)	28022848	51	32	51	20	18	6	9	14	3	1	0.574	1.000	1.000
555	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(2), AP2A1(1), AP2M1(1), ARF1(1), BTK(4), EEA1(3), GRASP(1), GSK3B(1), LYN(2), PFKL(6), PFKP(1), PLCG1(12), PRKCE(1), RAC1(1), RPS6KB1(2), VAV2(4)	29782188	43	32	41	21	11	11	6	8	7	0	0.710	1.000	1.000
556	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CCNH(2), CDK7(1), ERCC3(2), GTF2A2(1), GTF2E1(3), GTF2H1(3), GTF2H4(2), ILK(1), POLR1A(7), POLR1B(3), POLR2A(9), POLR2B(4), POLR2C(2), POLR2G(1), POLR3B(3), POLR3D(1), POLR3E(1), POLR3K(1), TAF6(2), TAF7(1), TAF9(2), TBP(2)	41741757	54	32	54	32	12	10	6	19	7	0	0.985	1.000	1.000
557	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BAG4(1), BIRC2(3), BIRC3(1), CASP8(2), CFLAR(1), MAP3K3(2), MAP3K7(3), NFKB1(2), NFKB2(3), NFKBIA(3), NFKBIE(3), NR2C2(3), RALBP1(3), RIPK1(4), TNF(1), TNFAIP3(2), TNFRSF1A(1), TNFRSF1B(3), TRADD(1), TRAF2(2)	32463848	44	32	44	16	14	8	7	9	6	0	0.506	1.000	1.000
558	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(1), DUSP1(1), IKBKAP(3), IKBKB(2), MAP3K1(10), NFKB1(2), NFKBIA(3), RELA(1), RIPK1(4), TANK(3), TNFAIP3(2), TNFRSF1B(3), TRAF1(1), TRAF2(2), TRAF3(2)	26765165	40	32	38	16	16	8	2	8	6	0	0.502	1.000	1.000
559	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(3), EXT2(3), EXTL1(4), EXTL2(2), EXTL3(1), HS3ST1(3), HS3ST3A1(3), HS6ST2(4), HS6ST3(1), NDST1(2), NDST2(2), NDST3(4), NDST4(8)	24746199	40	31	39	16	17	2	9	9	3	0	0.589	1.000	1.000
560	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(2), ELK1(5), FOS(2), IL2RB(2), JAK1(3), JAK3(5), LCK(1), MAP2K1(1), MAPK3(2), MAPK8(2), RAF1(2), SHC1(1), SOS1(7), STAT5A(1), STAT5B(2)	27914769	38	31	38	17	7	7	4	11	8	1	0.751	1.000	1.000
561	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(6), ICAM1(3), ITGA4(8), ITGAL(2), ITGB1(3), ITGB2(5), SELE(8)	14456646	35	31	34	19	13	5	8	4	5	0	0.755	1.000	1.000
562	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(19), C5(7), C6(4), C7(5), C8A(4), C9(2)	15000771	41	30	41	20	14	3	4	12	8	0	0.868	1.000	1.000
563	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CR1(5), CR2(9), HLA-DRA(4), HLA-DRB1(1), ICAM1(3), ITGAL(2), ITGB2(5), PTPRC(9)	18133639	38	30	38	19	14	7	1	8	8	0	0.784	1.000	1.000
564	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	ALDOA(1), ALDOB(2), FBP1(3), FBP2(2), FPGT(3), GCK(2), GMDS(1), GMPPA(2), HK1(4), HK2(5), HK3(5), MPI(2), PFKFB1(6), PFKFB3(2), PFKFB4(1), PFKP(1), PMM1(1), SORD(1), TPI1(1)	28529956	45	27	45	17	19	11	2	8	5	0	0.264	1.000	1.000
565	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B4GALNT1(3), GLB1(2), HEXA(1), HEXB(1), LCT(13), SLC33A1(4), ST3GAL1(3), ST3GAL2(1), ST6GALNAC3(3), ST6GALNAC4(1), ST6GALNAC6(1), ST8SIA1(2), ST8SIA5(3)	19633062	38	27	38	17	14	3	4	8	9	0	0.857	1.000	1.000
566	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(6), ICAM1(3), ITGAL(2), ITGAM(7), ITGB2(5), SELE(8)	12418944	31	27	30	20	15	4	5	3	4	0	0.860	1.000	1.000
567	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	DAB1(4), FYN(2), LRP8(1), RELN(26), VLDLR(2)	16701487	35	27	35	21	12	8	5	5	5	0	0.859	1.000	1.000
568	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	28	ANPEP(5), G6PD(3), GCLC(1), GGT1(3), GPX2(2), GPX5(1), GSS(2), GSTA1(3), GSTA2(1), GSTA3(1), GSTA4(4), GSTM4(1), GSTM5(1), GSTT1(1), GSTZ1(3), PGD(1)	19598721	33	26	33	13	9	7	6	6	5	0	0.552	1.000	1.000
569	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(1), ALDOB(2), FBP1(3), FBP2(2), G6PD(3), GPI(2), H6PD(3), PFKP(1), PGD(1), PGLS(1), PGM1(1), PGM3(1), PRPS1(1), PRPS1L1(3), PRPS2(5), RBKS(1), RPE(1), RPIA(1), TAL1(1), TALDO1(2), TKT(2)	24345899	38	26	38	19	14	9	2	6	7	0	0.650	1.000	1.000
570	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(3), ESR2(6), PDE1A(3), PDE1B(2), PLCB1(4), PLCB2(7), PRL(1), TRH(1), VIP(2)	13252033	29	26	29	12	9	7	0	8	5	0	0.671	1.000	1.000
571	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT2(1), B3GNT7(2), B4GALT2(1), CHST1(2), CHST2(2), CHST4(2), CHST6(2), FUT8(7), ST3GAL1(3), ST3GAL2(1), ST3GAL3(2), ST3GAL4(3)	14881592	28	25	28	11	12	4	5	4	3	0	0.496	1.000	1.000
572	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(7), POLR1B(3), POLR2A(9), POLR2B(4), POLR2C(2), POLR2G(1), POLR3A(7), POLR3B(3), POLR3G(1), POLR3GL(1), POLR3K(1)	27957084	39	25	39	14	10	6	7	11	5	0	0.505	1.000	1.000
573	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	BNIP1(3), GOSR2(1), SNAP29(1), STX11(2), STX16(1), STX5(1), STX6(1), STX7(1), TSNARE1(5), USE1(3), VAMP4(1), VAMP5(3), VAMP7(3), VAMP8(1), VTI1A(2)	19940765	29	25	28	13	11	3	6	5	4	0	0.705	1.000	1.000
574	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL22(2), IL22RA1(1), JAK1(3), JAK2(5), JAK3(5), STAT1(4), STAT3(3), STAT5A(1), STAT5B(2), TYK2(10)	21996920	36	25	36	15	12	1	2	14	6	1	0.750	1.000	1.000
575	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(5), ARHGEF1(1), GNA13(2), GNB1(1), MYL2(2), MYLK(7), PLCB1(4), PPP1R12B(1), PRKCA(6), ROCK1(4)	24616073	33	25	32	18	10	4	4	10	4	1	0.912	1.000	1.000
576	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	10	DNM1(1), GABRA2(3), GABRA3(4), GABRA4(10), GABRA5(4), GPHN(1), NSF(2), SRC(2), UBQLN1(2)	12026241	29	24	29	13	4	8	5	7	5	0	0.762	1.000	1.000
577	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	20	B3GNT2(1), B3GNT3(4), B3GNT4(2), B3GNT5(4), B4GALT2(1), FUT1(1), FUT2(2), FUT3(2), FUT4(1), FUT5(6), FUT6(3), FUT7(1), GCNT2(1), ST8SIA1(2)	18468689	31	24	31	16	11	3	3	8	6	0	0.896	1.000	1.000
578	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	14	AKT1(2), BPNT1(1), ILK(1), MAPK1(4), MAPK3(2), PDK1(2), PIK3CD(3), PTK2B(5), RBL2(4), SHC1(1), SOS1(7)	20730716	32	24	32	12	7	5	3	12	4	1	0.557	1.000	1.000
579	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(1), CD28(2), CD3D(1), CD3E(2), CD3G(1), CD8A(1), ICAM1(3), ITGAL(2), ITGB2(5), PTPRC(9)	12808049	27	24	26	19	12	4	1	6	4	0	0.951	1.000	1.000
580	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(1), CD28(2), CD3D(1), CD3E(2), CD3G(1), CD4(2), ICAM1(3), ITGAL(2), ITGB2(5), PTPRC(9)	13441645	28	24	27	19	12	4	1	7	4	0	0.948	1.000	1.000
581	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOA(1), ALDOB(2), FBP1(3), FBP2(2), GOT1(2), GOT2(1), ME1(2), ME3(1), PGK1(3), PGK2(1), PKLR(3), RPE(1), RPIA(1), TKT(2), TKTL1(1), TKTL2(3), TPI1(1)	24015823	30	23	30	18	10	5	1	10	4	0	0.954	1.000	1.000
582	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(3), PLCG1(12), PRKCA(6), PTK2B(5)	8024280	26	23	24	13	9	4	3	6	3	1	0.735	1.000	1.000
583	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(1), JAK1(3), JAK2(5), JAK3(5), PIAS1(2), PIAS3(3), PTPRU(3), REG1A(2), SOAT1(5)	16420173	29	23	29	11	5	3	3	10	8	0	0.709	1.000	1.000
584	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(1), DUSP1(1), IKBKAP(3), IKBKB(2), MAP3K1(10), NFKB1(2), NFKBIA(3), RELA(1), TNFAIP3(2), TRAF3(2), TRAF6(1)	21632780	28	22	26	12	10	6	2	7	3	0	0.622	1.000	1.000
585	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(1), ALOX15(2), ALOX15B(1), ALOX5(3), ALOX5AP(1), DPEP1(2), GGT1(3), LTA4H(4), PLA2G6(3), PTGES(1), PTGIS(2), PTGS1(3), PTGS2(3), TBXAS1(3)	17951364	32	22	32	14	11	8	2	5	6	0	0.599	1.000	1.000
586	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	13	AKT1(2), CREB1(2), MAP2K1(1), MAP2K2(1), MAP2K3(6), MAP3K1(10), MAPK1(4), MAPK3(2), NFKB1(2), RELA(1), SP1(1)	16582144	32	21	30	11	11	7	4	3	6	1	0.376	1.000	1.000
587	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(2), CYP51A1(2), DHCR24(2), DHCR7(4), FDFT1(1), FDPS(3), GGCX(1), GGPS1(1), HSD17B7(2), IDI1(2), IDI2(1), LSS(1), MVD(4), MVK(1), NQO1(1), NSDHL(2), SQLE(1)	23007515	31	21	30	12	9	4	7	8	3	0	0.638	1.000	1.000
588	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(2), ALDH1A2(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ECHS1(3), EHHADH(2), HADHA(3), SDS(1)	14490725	29	21	29	14	12	5	3	4	5	0	0.612	1.000	1.000
589	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOA(1), ALDOB(2), FBP1(3), FBP2(2), GOT1(2), GOT2(1), ME1(2), ME2(2), ME3(1), PGK1(3), PKLR(3), RPE(1), RPIA(1), TKT(2), TPI1(1)	21483548	27	20	27	14	8	5	1	10	3	0	0.879	1.000	1.000
590	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CSNK1D(2), DRD1(1), DRD2(1), GRM1(6), PLCB1(4), PPP1CA(1), PPP1R1B(1), PPP2CA(4), PPP3CA(1), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(1)	19129328	26	19	26	11	9	3	1	10	3	0	0.797	1.000	1.000
591	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(1), CD3D(1), CD3E(2), CD3G(1), GZMB(3), HLA-A(1), ICAM1(3), ITGAL(2), ITGB2(5), PRF1(3)	10411966	22	19	22	13	11	2	2	2	5	0	0.783	1.000	1.000
592	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(3), ADH1B(4), ADH5(1), ADH6(3), ADH7(2), ADHFE1(2), ALDH1A3(5), ALDH1B1(4), ALDH2(1), ALDH3A1(6), ALDH7A1(2)	15814919	33	19	33	14	12	2	3	14	2	0	0.701	1.000	1.000
593	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(3), CYSLTR2(3), GPR161(3), GPR171(1), GPR18(2), GPR34(4), GPR45(4), GPR65(2), GPR68(1), GPR75(2)	11729640	25	18	25	11	8	3	4	4	6	0	0.562	1.000	1.000
594	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(1), ASPH(3), CREB1(2), EP300(6), EPO(2), LDHA(1), NOS3(10), P4HB(1)	20315057	26	18	26	13	11	2	2	8	3	0	0.836	1.000	1.000
595	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(4), ACAD9(1), ADH1A(3), ADH1B(4), ADH5(1), ADH6(3), ADH7(2), ADHFE1(2), DHRS2(2), DHRS3(1), DHRS7(1), DHRSX(1), ESCO1(2), ESCO2(2), PNPLA3(1), SH3GLB1(3)	29774380	33	18	32	14	7	7	2	16	1	0	0.806	1.000	1.000
596	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT2(1), ACOT11(4), ACYP1(1), DHRS2(2), DHRS3(1), DHRS7(1), DHRSX(1), ECHS1(3), EHHADH(2), ESCO1(2), ESCO2(2), GCDH(1), HADHA(3), PNPLA3(1), SH3GLB1(3), YOD1(1)	30938629	29	18	28	11	9	9	3	4	4	0	0.475	1.000	1.000
597	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(4), DHFR(1), HPRT1(1), IMPDH1(6), OAZ1(1), POLB(3), POLD1(3), POLG(1), PRPS2(5), RRM1(3), SRM(2)	14907314	30	17	30	13	11	5	5	5	4	0	0.594	1.000	1.000
598	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(2), FOSL2(2), IFNAR1(2), IFNAR2(2), IFNB1(2), MAPK8(2), NFKB1(2), RELA(1), TNFRSF11A(5), TNFSF11(1), TRAF6(1)	13220822	22	17	22	12	4	6	2	8	2	0	0.854	1.000	1.000
599	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	17	ACTR2(2), ACTR3(1), ARPC1A(1), ARPC1B(2), ARPC2(1), ARPC3(1), ARPC4(1), NCKAP1(5), NTRK1(3), RAC1(1), WASF1(1), WASF2(1), WASF3(4), WASL(2)	17281881	26	16	26	11	3	4	4	9	6	0	0.796	1.000	1.000
600	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	GLB1(2), GUSB(3), HEXA(1), HEXB(1), IDS(2), LCT(13), NAGLU(3)	17168353	25	16	25	11	10	3	4	4	4	0	0.674	1.000	1.000
601	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(3), POLD1(3), POLD2(2), POLE(8), POLG(1), POLL(2), POLQ(8)	19867316	27	15	27	16	9	4	2	11	1	0	0.955	1.000	1.000
602	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	CLOCK(3), CRY1(3), CSNK1D(2), CSNK1E(1), NPAS2(1), NR1D1(1), PER1(6), PER2(6), PER3(2)	20385302	25	15	24	13	6	7	1	9	2	0	0.898	1.000	1.000
603	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(2), HMOX1(1), IL10(1), IL10RB(1), IL1A(1), IL6(2), JAK1(3), STAT1(4), STAT3(3), STAT5A(1), TNF(1)	14506535	20	15	20	10	4	3	2	8	2	1	0.788	1.000	1.000
604	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACAA1(1), ACOX1(2), ACOX3(3), ELOVL2(2), ELOVL6(1), FADS2(2), FASN(3), HADHA(3), PECR(2), SCD(1)	17136219	20	14	20	17	4	5	2	7	2	0	0.984	1.000	1.000
605	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	C9orf47(1), CNR1(1), CNR2(3), DNMT1(4), MTNR1A(2), MTNR1B(2), PTAFR(2), PTGER4(2), PTGFR(7), TBXA2R(1)	13354687	25	13	25	18	9	3	0	9	4	0	0.961	1.000	1.000
606	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARF1(1), ARFGEF2(6), CLTA(1), COPA(2), GBF1(4), GPLD1(1), KDELR1(1), KDELR2(1), KDELR3(1)	19319373	18	12	18	11	3	6	3	3	3	0	0.894	1.000	1.000
607	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(1), ACAA2(3), ACAT2(1), ECHS1(3), EHHADH(2), HADHA(3), SDS(1)	9952347	14	12	14	10	2	4	2	2	4	0	0.921	1.000	1.000
608	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	FUT1(1), FUT2(2), GBGT1(2), GLA(2), HEXA(1), HEXB(1), ST3GAL1(3), ST3GAL2(1), ST3GAL4(3), ST8SIA1(2)	12050622	18	12	18	12	6	1	1	6	4	0	0.986	1.000	1.000
609	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	B3GALNT1(2), B3GALT5(2), FUT1(1), FUT2(2), GBGT1(2), GLA(2), HEXA(1), HEXB(1), ST3GAL1(3), ST3GAL2(1), ST8SIA1(2)	12790157	19	12	19	14	5	1	1	8	4	0	0.995	1.000	1.000
610	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	CDC34(2), NRF1(2), UBE2E3(1), UBE2G2(1), UBE2L6(1), UBE2M(2), UBE3A(2)	12548074	11	11	11	11	5	1	2	1	2	0	0.985	1.000	1.000
611	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(3), ADH1B(4), ADH6(3), ADH7(2), ADHFE1(2)	6712742	14	9	14	8	2	1	1	10	0	0	0.911	1.000	1.000
612	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(3), EPHX2(2), HSD3B7(1)	5714325	6	6	6	5	3	0	0	3	0	0	0.958	1.000	1.000
613	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA3(2), LTB4R(1), P2RY1(1), P2RY2(3), P2RY6(2)	7106904	9	4	9	8	5	2	0	2	0	0	0.944	1.000	1.000
614	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		605530	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
615	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2		1822269	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
616	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3		2037005	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
