rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1	CMBL(2)	387333	2	2	2	0	0	0	0	0	2	0	0.660	0.289	1.000
2	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(2), PAPSS1(6), PAPSS2(6), SULT1A2(2), SULT1E1(5), SULT2A1(2), SUOX(2)	4654771	25	23	25	2	5	7	5	5	3	0	0.0271	0.363	1.000
3	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(3), PGLYRP2(6)	1385935	9	9	9	2	1	3	2	2	1	0	0.347	0.596	1.000
4	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(2), TPI1(4)	1259018	6	6	6	2	1	3	2	0	0	0	0.649	0.692	1.000
5	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	7	CCNE1(4), CDC34(4), CUL1(11), RB1(17), TFDP1(2)	5002135	38	33	38	8	3	11	5	3	16	0	0.108	0.705	1.000
6	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(3), CDC25B(4), CHEK1(1), NEK1(9), WEE1(2)	5234638	19	19	19	1	4	4	6	1	4	0	0.0923	0.727	1.000
7	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(4), RAB11A(1), RAB1A(2), RAB3A(2), RAB4A(1), RAB5A(3)	3216067	13	13	13	1	5	4	2	1	1	0	0.0409	0.737	1.000
8	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(6), CYP2C9(6)	1540877	12	12	12	3	0	4	5	2	1	0	0.411	0.761	1.000
9	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALT(2), TGDS(3), UGDH(3), UXS1(2)	2930825	10	10	10	0	0	1	5	3	1	0	0.131	0.779	1.000
10	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD28(3), CD4(1), HLA-DRA(1), HLA-DRB1(2)	1803977	7	7	6	2	0	1	0	3	3	0	0.747	0.790	1.000
11	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(1)	550302	1	1	1	1	0	0	0	1	0	0	0.924	0.819	1.000
12	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(1), ALDH1A2(10), RDH5(1)	2972225	12	12	12	2	1	1	5	2	3	0	0.404	0.824	1.000
13	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(2), GSTZ1(1), HGD(4)	1699430	7	7	7	2	1	4	1	0	1	0	0.418	0.838	1.000
14	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALT(2), TGDS(3), UGDH(3), UGP2(2), UXS1(2)	3731305	12	12	12	0	0	1	7	3	1	0	0.0936	0.850	1.000
15	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	LPL(4), NR3C1(6), PPARG(1), RXRA(4)	4408546	15	15	15	1	2	4	5	2	2	0	0.0366	0.854	1.000
16	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(10), PARK2(4), SNCA(1), SNCAIP(4), UBE2L3(2), UBE2L6(2)	4900386	23	21	23	4	4	5	5	7	2	0	0.140	0.896	1.000
17	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(3), PLCD1(5), PRKCA(7), TGM2(4)	3767281	19	19	19	4	2	6	5	3	3	0	0.104	0.925	1.000
18	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	CDK5(3), FOSB(2), GRIA2(16), JUND(1)	2848398	22	22	22	7	4	5	10	2	1	0	0.393	0.940	1.000
19	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIPT1(1)	1163469	1	1	1	0	0	0	0	1	0	0	0.757	0.950	1.000
20	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	5	C3(15), C5(10), C7(12), C8A(8), C9(15)	8116618	60	52	59	11	10	17	19	10	4	0	0.0272	0.953	1.000
21	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	B3GNT1(3), FUT2(2), FUT9(11), GCNT2(5), ST8SIA1(3)	4707553	24	23	23	5	3	6	13	2	0	0	0.153	0.957	1.000
22	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	BPNT1(2), CHST11(3), CHST12(6), CHST13(7), PAPSS1(6), PAPSS2(6), SULT1A1(2), SULT1A2(2), SULT1E1(5), SULT2A1(2), SUOX(2)	7066234	43	39	43	7	11	7	11	8	6	0	0.0371	0.963	1.000
23	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCR3(5), HLA-DRA(1), HLA-DRB1(2), IL3(1), IL5(2)	2309391	11	11	10	4	0	3	4	0	4	0	0.699	0.969	1.000
24	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(4), PSMA2(1), PSMA3(2), PSMA4(1), PSMA5(1), PSMA6(2), PSMB1(1), PSMB10(3), PSMB2(1), PSMB3(1), PSMB4(2), PSMB5(3), PSMB6(1), PSMB7(1), PSMB8(1), PSMB9(2)	6648166	27	25	27	4	1	5	10	7	4	0	0.128	0.971	1.000
25	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3D(1)	862651	1	1	1	1	0	0	1	0	0	0	0.944	0.972	1.000
26	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(21), GNAS(13), GNB1(3), PRKACA(4), PRKAR1A(4)	5059800	45	38	44	8	15	6	14	6	4	0	0.0427	0.979	1.000
27	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	FUT2(2), FUT3(3), FUT5(4), FUT6(2), ST3GAL3(4)	3907972	15	14	15	3	3	3	6	2	1	0	0.191	0.983	1.000
28	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	AOC2(6), AOC3(5), CES1(6), ESD(3)	4610630	20	19	20	4	3	9	6	0	2	0	0.101	0.987	1.000
29	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(2), IFNG(2), IL12A(1), IL12B(3), IL18(1), IL2(2)	2272852	11	11	11	4	1	1	2	4	3	0	0.838	0.988	1.000
30	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(4)	1302996	4	4	4	3	0	1	2	0	1	0	0.872	0.989	1.000
31	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(3), AASDHPPT(3), AASS(3), KARS(4)	3590576	13	13	13	3	1	2	2	3	5	0	0.441	0.990	1.000
32	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(5), CYP2E1(6), NR1I3(1), PTGS1(7), PTGS2(3)	4066446	22	20	22	6	1	1	11	1	8	0	0.486	0.992	1.000
33	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(1), GOT2(2), TAT(2)	2001633	5	5	5	2	0	0	3	1	1	0	0.768	0.992	1.000
34	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(2), CDO1(2), CSAD(4), GAD1(4), GAD2(6), GGT1(4)	4389193	22	22	22	5	4	6	5	2	5	0	0.173	0.992	1.000
35	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(5), SUCLA2(2)	1605413	7	7	7	3	1	2	3	1	0	0	0.692	0.994	1.000
36	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	13	AKT1(2), BAD(1), CASP9(1), CHUK(6), GH1(4), GHR(9), NFKB1(5), NFKBIA(1), PDPK1(4), PIK3R1(9), RELA(2), YWHAH(2)	9093067	46	41	45	9	5	11	11	7	12	0	0.127	0.996	1.000
37	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(6), FOSL1(3), FOSL2(10), IFNAR1(2), IFNAR2(2), MAPK8(4), NFKB1(5), RELA(2), TNFRSF11A(3), TNFSF11(1), TRAF6(3)	8459745	41	38	41	8	6	9	10	7	9	0	0.226	0.997	1.000
38	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(2), HLCS(1), SPCS1(2), SPCS3(1)	2326227	6	6	6	5	0	2	1	0	3	0	0.911	0.997	1.000
39	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	11	APAF1(12), ARHGAP5(10), ARHGDIB(1), CASP1(2), CASP10(2), CASP3(2), CASP9(1), GZMB(2), JUN(1), PRF1(5)	8942139	38	35	38	7	5	9	5	11	8	0	0.149	0.998	1.000
40	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(2), ADH1B(2), ADH4(2), ADH6(1), ADH7(2), ADHFE1(4)	4292194	13	12	13	4	1	3	2	2	5	0	0.634	0.998	1.000
41	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(3), SEC61A2(4), SRP54(2), SRP68(5), SRP72(1), SRPR(3)	5742620	18	17	18	3	3	8	5	1	1	0	0.168	0.998	1.000
42	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	16	CD28(3), CD3D(1), CD80(4), CD86(2), CTLA4(2), HLA-DRA(1), HLA-DRB1(2), ICOS(1), IL2(2), ITK(3), LCK(5), PIK3R1(9), PTPN11(2)	8067800	37	32	36	7	0	7	7	9	14	0	0.177	0.999	1.000
43	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(1), DCN(4), FMOD(7), KERA(4), LUM(2)	2762619	18	14	18	6	1	8	5	2	2	0	0.389	0.999	1.000
44	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(1), F13B(13), HSD17B1(2), HSD17B2(2), HSD17B3(2), HSD17B4(5), HSD17B7(1), HSD3B1(4), HSD3B2(4)	6173621	34	32	34	9	5	7	12	6	4	0	0.286	0.999	1.000
45	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD28(3), CD4(1), CD80(4), HLA-DRA(1), HLA-DRB1(2), IL2(2), IL4(1)	3023870	14	14	13	5	0	4	3	4	3	0	0.703	0.999	1.000
46	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(1), ECHS1(2), EHHADH(5), HADHA(3), SDS(1)	3691094	12	10	12	3	0	4	3	3	2	0	0.472	0.999	1.000
47	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(1), CD34(5), CD3D(1), CD4(1), CD58(2), CD8A(3), IL3(1), IL6(2), KITLG(1)	4712361	17	16	17	5	2	2	2	4	7	0	0.535	0.999	1.000
48	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(4), FDPS(2), GGPS1(1), IDI1(1), IDI2(1)	3259670	9	9	9	3	2	5	1	1	0	0	0.406	0.999	1.000
49	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT2(2), HMGCL(1), OXCT1(1)	2574695	4	4	4	2	1	0	1	0	2	0	0.857	0.999	1.000
50	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	FABP6(3), LDLR(4), NR0B2(1), NR1H3(1), NR1H4(6), RXRA(4)	4151822	19	18	18	5	4	5	5	1	4	0	0.308	0.999	1.000
51	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(4), ACADM(3), ACADS(2), ECHS1(2), HADHA(3)	4121663	14	14	14	4	2	3	4	4	1	0	0.547	0.999	1.000
52	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(4), HK1(4), HK2(6), HK3(8), IMPA1(2), PGM1(5), PGM3(1), TGDS(3)	7784242	33	32	33	6	7	9	8	3	6	0	0.0490	0.999	1.000
53	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	SNAP25(3), STX1A(5)	2478478	8	8	8	3	4	0	3	1	0	0	0.726	0.999	1.000
54	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(7), CCNE1(4), CDC34(4), CUL1(11), RB1(17), SKP2(4), TFDP1(2)	6487151	49	43	49	12	4	11	12	5	17	0	0.218	1.000	1.000
55	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(1), GLS2(2), GLUD1(3), GLUD2(10)	3476172	16	16	16	6	4	1	4	3	4	0	0.749	1.000	1.000
56	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(4), BCKDK(6), CTH(3), MUT(5)	3737326	18	17	18	5	2	6	4	3	3	0	0.473	1.000	1.000
57	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(2), IFNGR1(4), IFNGR2(4), JAK1(10), JAK2(5), STAT1(8)	6237387	33	29	32	9	2	9	8	5	9	0	0.257	1.000	1.000
58	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(7), GOT1(1), GOT2(2), TAT(2), TYR(8)	3584284	20	18	20	6	2	3	10	1	4	0	0.520	1.000	1.000
59	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(4), FDPS(2), IDI1(1)	2437437	7	7	7	3	2	4	1	0	0	0	0.550	1.000	1.000
60	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ3(2), COQ5(7), COQ6(2), COQ7(2), NDUFA12(1), NDUFA13(2)	3054940	16	15	16	6	2	3	6	2	3	0	0.686	1.000	1.000
61	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(8), ACO2(4), FH(3), IDH1(4), IDH2(1), MDH1(1), MDH2(1), SDHB(1), SUCLA2(2)	6778760	25	22	25	5	4	8	10	1	2	0	0.137	1.000	1.000
62	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCR3(5), CD4(1), HLA-DRA(1), HLA-DRB1(2), IL1B(1), IL4(1), IL5(2), IL5RA(3), IL6(2)	4060506	18	18	17	6	1	4	8	2	3	0	0.600	1.000	1.000
63	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CD28(3), CD3D(1), CD4(1)	2444270	5	5	5	3	0	0	1	3	1	0	0.904	1.000	1.000
64	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(5), B4GALT7(2), HS3ST2(2), HS3ST3A1(3), HS3ST3B1(1), XYLT1(10), XYLT2(3)	5051402	26	25	26	7	4	3	7	7	5	0	0.331	1.000	1.000
65	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(5), B4GALT7(2), HS3ST2(2), HS3ST3A1(3), HS3ST3B1(1), XYLT1(10), XYLT2(3)	5051402	26	25	26	7	4	3	7	7	5	0	0.331	1.000	1.000
66	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(6), ANKRD1(1), CYR61(2), DUSP14(4), EIF4E(1), EIF4EBP1(1), IFNG(2), IFRD1(5), IL18(1), IL1A(1), IL1R1(4), JUND(1), MYOG(3), NR4A3(3), WDR1(3)	8163969	38	34	38	9	5	7	8	13	5	0	0.302	1.000	1.000
67	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(3), B4GALT1(1), B4GALT2(5), B4GALT3(1), B4GALT5(3), FUT8(2), ST3GAL1(2), ST3GAL2(1), ST3GAL3(4), ST3GAL4(1)	6045395	23	21	23	5	6	3	7	2	5	0	0.307	1.000	1.000
68	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(5), FARSA(1), FARSB(8), GOT1(1), GOT2(2), PAH(7), TAT(2), YARS(6), YARS2(4)	6628304	36	34	36	9	2	11	13	5	5	0	0.159	1.000	1.000
69	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT2(2), ACYP1(1), ECHS1(2), EHHADH(5), GCDH(2), HADHA(3), SDHB(1), SDS(1)	5951533	17	16	17	4	2	4	5	4	2	0	0.379	1.000	1.000
70	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(1), GPD2(5), NDUFA1(1), SDHA(6), SDHB(1), SDHC(1), UQCRC1(1)	5040611	16	16	15	4	1	4	6	4	1	0	0.399	1.000	1.000
71	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	GNB1(3), HTR2C(4), PLCB1(22), TUB(3)	5443928	32	32	31	9	7	5	13	5	2	0	0.331	1.000	1.000
72	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(5), CHPT1(2), HEMK1(1), LCMT1(2), LCMT2(6), METTL2B(3), METTL6(2), PCYT1A(2), PCYT1B(2), PRMT2(2), PRMT3(6), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(6)	10687545	47	41	47	8	11	11	12	6	7	0	0.0219	1.000	1.000
73	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	10	CREB1(1), FOS(6), JUN(1), MAPK14(2), MAPK8(4), PRKCA(7)	4461363	21	19	21	7	1	6	6	3	5	0	0.510	1.000	1.000
74	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(3), AASDH(5), AASDHPPT(3), AASS(3), KARS(4)	5293186	18	18	18	5	1	2	3	6	6	0	0.542	1.000	1.000
75	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	10	C1QA(2), C1R(3), C1S(6), C2(5), C3(15), C5(10), C7(12), C8A(8), C9(15)	11896421	76	64	75	16	10	25	24	12	5	0	0.0221	1.000	1.000
76	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(3), ST3GAL1(2), ST3GAL2(1), ST3GAL4(1), ST3GAL5(5), ST6GALNAC2(2), ST8SIA1(3)	4308320	17	17	17	5	4	4	4	2	3	0	0.295	1.000	1.000
77	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CASP3(2), CD36(1), FOS(6), FYN(4), JUN(1), MAPK14(2), THBS1(8)	5649868	24	22	24	7	3	6	5	6	4	0	0.310	1.000	1.000
78	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(1), MTMR1(2), MTMR2(3), MTMR6(3), NFS1(1), PHPT1(1), TPK1(3)	4877663	14	13	14	4	3	3	4	3	1	0	0.567	1.000	1.000
79	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	17	APAF1(12), BAK1(1), BCL2(1), BCL2L1(2), BID(3), BIK(2), BIRC2(3), BIRC3(2), CASP3(2), CASP6(5), CASP7(3), CASP9(1), DIABLO(1)	9340788	38	35	38	7	4	14	4	6	10	0	0.0786	1.000	1.000
80	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	18	CSNK2A1(7), ELK1(2), FOS(6), INSR(3), IRS1(2), JUN(1), MAP2K1(5), MAPK8(4), PIK3R1(9), PTPN11(2), RAF1(3), SHC1(2), SLC2A4(3), SOS1(9), SRF(1)	15860323	59	52	59	9	7	9	20	9	14	0	0.0164	1.000	1.000
81	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	16	CSNK2A1(7), ELK1(2), FOS(6), JUN(1), KLK2(2), MAP2K1(5), MAPK8(4), NGFR(1), PIK3R1(9), PLCG1(9), RAF1(3), SHC1(2), SOS1(9)	12537919	60	54	60	10	10	8	22	7	13	0	0.0436	1.000	1.000
82	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(12), BAD(1), BAK1(1), BCL10(1), BCL2(1), BCL2L1(2), BCL2L11(1), BID(3), CASP9(1), CES1(6)	8339516	29	29	29	6	4	9	4	5	7	0	0.240	1.000	1.000
83	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(8), GAD1(4), HDC(4), PNMT(1), TH(3), TPH1(3)	4614627	23	23	23	8	3	2	11	2	5	0	0.621	1.000	1.000
84	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(5), ERBB4(22), NRG2(5), NRG3(19), PRKCA(7)	6848799	58	52	58	15	4	10	22	12	10	0	0.333	1.000	1.000
85	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	ATP6V0C(1), GGT1(4), SHMT1(1), SHMT2(3)	3169211	9	9	9	5	3	0	3	1	2	0	0.886	1.000	1.000
86	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	ANP32A(1), APEX1(1), CREBBP(37), GZMA(2), GZMB(2), HMGB2(2), PRF1(5), SET(1)	8090593	51	44	50	12	9	8	14	10	9	1	0.145	1.000	1.000
87	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(4), HK1(4), HK2(6), HK3(8), IMPA1(2), IMPA2(2), ISYNA1(4), PGM1(5), PGM3(1), TGDS(3)	8888555	39	37	39	9	9	10	10	3	7	0	0.0645	1.000	1.000
88	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(1), ECHS1(2), HADH(4), HADHA(3), HADHB(4), HSD17B10(1), HSD17B4(5), MECR(3), PPT1(1), PPT2(2)	6455846	26	23	26	7	2	3	9	8	4	0	0.433	1.000	1.000
89	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	20	CEBPB(1), CSNK2A1(7), ELK1(2), FOS(6), IL6(2), IL6R(6), IL6ST(5), JAK1(10), JAK2(5), JAK3(6), JUN(1), MAP2K1(5), PTPN11(2), RAF1(3), SHC1(2), SOS1(9), SRF(1), STAT3(6)	17812851	79	70	79	12	14	12	26	16	11	0	0.00246	1.000	1.000
90	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(2), CDC25A(3), CDC25B(4), CDC25C(4), MNAT1(1), SHH(2), XPO1(6)	6576401	22	21	22	5	6	6	2	5	3	0	0.290	1.000	1.000
91	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	11	AKT1(2), CAT(4), GH1(4), GHR(9), IGF1(1), IGF1R(11), PIK3R1(9), SHC1(2), SOD1(1), SOD2(1), SOD3(4)	8144395	48	42	48	11	10	10	12	9	7	0	0.114	1.000	1.000
92	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(11), PDXK(1), PSAT1(1)	3694776	13	11	13	6	1	2	2	6	2	0	0.850	1.000	1.000
93	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	CCL2(2), CSF1(2), IL6(2), LDLR(4), LPL(4)	4050270	14	14	13	5	2	4	6	1	1	0	0.567	1.000	1.000
94	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	11	ATM(16), CDC25A(3), CDC25B(4), CDC25C(4), CDK4(5), CHEK1(1), MYT1(11), RB1(17), WEE1(2), YWHAH(2)	12748481	65	58	65	11	7	15	13	8	22	0	0.0933	1.000	1.000
95	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(16), CDC25A(3), CDC25B(4), CDC25C(4), CHEK1(1), MYT1(11), WEE1(2), YWHAH(2)	10473104	43	37	43	8	7	10	10	8	8	0	0.169	1.000	1.000
96	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	8	CHUK(6), DNAJC3(3), EIF2S1(2), EIF2S2(6), NFKB1(5), NFKBIA(1), RELA(2)	6870155	25	24	25	9	4	5	5	4	7	0	0.669	1.000	1.000
97	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	13	C1QA(2), C1R(3), C1S(6), C2(5), C3(15), C5(10), C7(12), C8A(8), C9(15), MASP1(7), MASP2(5), MBL2(2)	14797003	90	72	88	19	12	27	24	19	8	0	0.0156	1.000	1.000
98	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA2(1), ACAT2(2), ECHS1(2), EHHADH(5), HADHA(3), HADHB(4), SDS(1)	6363842	18	16	18	5	1	3	7	5	2	0	0.569	1.000	1.000
99	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA1(1), NDUFA5(3), NDUFB2(2), NDUFB4(1), NDUFB6(1), NDUFS1(1), NDUFS2(3), NDUFV1(3)	5296122	15	14	15	4	3	5	5	1	1	0	0.423	1.000	1.000
100	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(1), CD8A(3), CSF1(2), EPO(2), IL2(2), IL3(1), IL4(1), IL5(2), IL6(2), IL7(2), IL9(2)	4632206	20	20	20	9	4	3	7	3	3	0	0.751	1.000	1.000
101	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(21), CREM(1), FHL5(5), FSHB(2), FSHR(12), GNAS(13), XPO1(6)	7324088	60	51	59	13	14	11	19	13	3	0	0.127	1.000	1.000
102	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	6	CREBBP(37), LPL(4), NCOA1(7), NCOA2(9), PPARG(1), RXRA(4)	10330966	62	50	61	14	6	13	18	15	9	1	0.138	1.000	1.000
103	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(3), POLR2A(12), POLR2B(9), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(3), POLR2G(4), POLR2H(1), POLR2I(1), POLR2J(2), POLR2L(3), POLRMT(6)	10275904	47	41	47	9	3	9	18	6	11	0	0.0963	1.000	1.000
104	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ARG1(1), GLS(1), GLUD1(3), OAT(1), PRODH(1)	4223754	7	7	7	3	0	1	1	3	2	0	0.754	1.000	1.000
105	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(4), PSMA2(1), PSMA3(2), PSMA4(1), PSMA5(1), PSMA6(2), PSMB1(1), PSMB2(1), PSMB3(1), PSMB4(2), PSMB5(3), PSMB6(1), PSMB7(1), PSMC3(2), PSMD14(1), RPN1(2), RPN2(6), UBE3A(6)	9816929	38	33	38	8	1	8	14	10	5	0	0.213	1.000	1.000
106	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(1), DAG1(5), ITPKB(5)	4623535	11	9	11	4	1	3	4	1	2	0	0.609	1.000	1.000
107	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	6	ATM(16), ATR(24), CDC25C(4), CHEK1(1), CHEK2(4), YWHAH(2)	11559436	51	47	51	9	4	15	10	14	8	0	0.161	1.000	1.000
108	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(4), CS(3), MDH1(1), ME1(2), PC(14), PDHA1(4)	7071633	28	28	28	8	4	8	6	5	5	0	0.279	1.000	1.000
109	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM1(1), CALM2(2), CALM3(2), CCL2(2), CCL4(1), CXCL12(3), CXCR4(2), FOS(6), JUN(1), MAPK14(2), MAPK8(4), PLCG1(9), PRKCA(7), PTK2B(4), SYT1(9)	10511573	55	49	55	13	8	10	19	14	4	0	0.0943	1.000	1.000
110	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	13	CUZD1(2), FOS(6), JUN(1), MAP2K1(5), MYC(6), NFKB1(5), NFKBIA(1), PLCB1(22), PRKCA(7), RAF1(3), RELA(2)	11025003	60	56	57	15	8	13	24	8	7	0	0.0825	1.000	1.000
111	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	ASRGL1(1), GBA(2), GGT1(4), SHMT1(1), SHMT2(3)	4201908	11	11	11	5	5	1	2	1	2	0	0.722	1.000	1.000
112	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	4	ADAM17(5), DLL1(5), FURIN(1)	3967260	11	11	11	5	3	3	2	1	2	0	0.738	1.000	1.000
113	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(7), DYRK1B(9), GLI2(16), GLI3(12), GSK3B(3), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), SHH(2), SMO(3), SUFU(3)	12690994	71	62	70	16	12	18	24	8	9	0	0.0393	1.000	1.000
114	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	16	IL18(1), ITGB1(15), KLRC1(1), KLRC2(1), KLRC3(3), KLRC4(1), LAT(3), MAP2K1(5), PAK1(3), PIK3R1(9), PTK2B(4), PTPN6(3), SYK(8), VAV1(7)	11415072	64	53	63	13	14	7	14	9	20	0	0.132	1.000	1.000
115	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	6	HDAC1(1), MAX(1), MYC(6), SP1(3), SP3(3), WT1(3)	4756021	17	17	15	7	0	4	8	3	2	0	0.770	1.000	1.000
116	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(4), EPHA4(11), EPHB1(15), FYN(4), ITGA1(4), ITGB1(15), L1CAM(10), LYN(8), RAP1B(3), SELP(16)	12031630	90	63	88	19	13	17	24	18	18	0	0.0606	1.000	1.000
117	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(4), BMPR1B(4), BMPR2(6)	4770080	14	14	14	5	3	4	4	1	2	0	0.655	1.000	1.000
118	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(2), RANBP2(14)	6426979	16	16	16	9	3	4	5	0	4	0	0.956	1.000	1.000
119	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(4), CTH(3), GOT1(1), GOT2(2), LDHA(1), LDHB(1), LDHC(4), MPST(2)	5220421	18	16	18	6	4	1	10	2	1	0	0.635	1.000	1.000
120	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	17	CSNK2A1(7), ELK1(2), FOS(6), IGF1(1), IGF1R(11), IRS1(2), JUN(1), MAP2K1(5), MAPK8(4), PIK3R1(9), PTPN11(2), RAF1(3), SHC1(2), SOS1(9), SRF(1)	15328284	65	57	65	11	11	11	20	10	13	0	0.0185	1.000	1.000
121	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	6	AKT1(2), PIK3R1(9), PLCB1(22), PLCG1(9), PRKCA(7), VAV1(7)	8098139	56	51	55	14	7	8	21	9	11	0	0.337	1.000	1.000
122	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(9), EPO(2), EPOR(1), GRIN1(4), HIF1A(4), JAK2(5), NFKB1(5), NFKBIA(1), RELA(2), SOD2(1)	9683106	34	34	34	9	5	11	6	7	5	0	0.175	1.000	1.000
123	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	12	C1QA(2), C1R(3), C1S(6), C2(5), C3(15), C5(10), C7(12), C8A(8), C8B(9), C9(15), MASP1(7)	14408376	92	74	90	22	12	26	28	18	8	0	0.0505	1.000	1.000
124	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	11	APC(27), CDH1(5), CREBBP(37), MAP2K1(5), MAP3K7(8), SKIL(4), TGFB1(1), TGFB2(4), TGFB3(1), TGFBR1(2)	14914179	94	73	91	19	10	15	30	20	18	1	0.127	1.000	1.000
125	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	11	CCNE1(4), CDKN1B(2), CKS1B(3), CUL1(11), RB1(17), RBX1(3), SKP2(4), TFDP1(2), UBE2M(3)	6398753	49	45	49	14	3	12	9	7	18	0	0.340	1.000	1.000
126	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT2(2), BDH1(1), BDH2(1), HMGCL(1), HMGCS1(3), HMGCS2(2), OXCT1(1), OXCT2(1)	5482791	12	11	12	8	3	2	2	3	2	0	0.943	1.000	1.000
127	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD28(3), CD86(2), HLA-DRA(1), HLA-DRB1(2), IFNG(2), IFNGR1(4), IFNGR2(4), IL12A(1), IL12B(3), IL12RB1(3), IL12RB2(10), IL18(1), IL18R1(3), IL2(2), IL2RA(2), IL4(1), IL4R(8)	9637613	52	46	50	14	4	9	15	8	16	0	0.291	1.000	1.000
128	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	B3GALT1(2), B3GALT2(1), B3GALT5(1), B3GNT5(2), FUT2(2), FUT3(3), ST3GAL3(4), ST3GAL4(1)	5514832	16	15	16	7	4	2	6	2	2	0	0.779	1.000	1.000
129	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	16	B3GAT1(2), B3GAT2(1), B3GAT3(5), B4GALT7(2), CHPF(7), CHST11(3), CHST12(6), CHST13(7), CHST14(2), CHST7(1), CHSY1(3), DSE(2), UST(2), XYLT1(10), XYLT2(3)	10714043	56	50	56	12	14	5	18	11	8	0	0.0709	1.000	1.000
130	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	13	AKT1(2), CREB1(1), MAPK7(6), MEF2A(3), MEF2B(5), MEF2D(1), NTRK1(3), PIK3R1(9), PLCG1(9), RPS6KA1(10), SHC1(2)	11234200	51	45	51	11	10	8	13	12	8	0	0.158	1.000	1.000
131	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	19	F2(3), F2R(4), F2RL3(3), GNAI1(2), GNB1(3), ITGA1(4), ITGB1(15), MAP2K1(5), PLA2G4A(3), PLCB1(22), PRKCA(7), PTGS1(7), PTK2(8), RAF1(3), SRC(1), SYK(8), TBXAS1(5)	17740314	103	84	101	22	15	17	33	19	19	0	0.0283	1.000	1.000
132	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	9	CASP3(2), CASP7(3), GZMB(2), HMGB1(1), HMGB2(2), TOP2A(5), TOP2B(4)	6732916	19	16	19	9	2	6	6	2	3	0	0.937	1.000	1.000
133	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(1), FUT2(2), FUT9(11), GBGT1(4), GLA(2), HEXA(4), NAGA(4), ST3GAL1(2), ST3GAL2(1), ST3GAL4(1), ST8SIA1(3)	7727050	35	32	35	10	7	7	13	4	4	0	0.196	1.000	1.000
134	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(1), GNAS(13), GNB1(3), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), PRKCA(7)	7329209	40	35	40	10	13	9	9	4	5	0	0.185	1.000	1.000
135	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	16	AKT1(2), ANXA1(2), CALM1(1), CALM2(2), CALM3(2), GNAS(13), GNB1(3), NFKB1(5), NOS3(4), NPPA(3), NR3C1(6), PIK3R1(9), RELA(2), SYT1(9)	12010112	63	51	63	13	13	12	15	12	11	0	0.103	1.000	1.000
136	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(2), CDC25A(3), CDC25B(4), CDC25C(4), CSK(1), PRKCA(7), PTPRA(2), SRC(1)	7005394	24	23	24	8	5	8	5	2	4	0	0.412	1.000	1.000
137	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	18	ADCY1(21), ARHGEF1(8), F2(3), F2R(4), F2RL3(3), GNA12(1), GNA13(2), GNAI1(2), GNB1(3), MAP3K7(8), PIK3R1(9), PLCB1(22), PPP1R12B(4), PRKCA(7), PTK2B(4), ROCK1(19)	18058312	120	97	117	26	19	22	41	22	16	0	0.0185	1.000	1.000
138	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CCL3(1), EPO(2), FLT3(6), IGF1(1), IL1A(1), IL3(1), IL6(2), IL9(2), KITLG(1), TGFB1(1), TGFB2(4), TGFB3(1)	6301711	23	20	23	9	6	2	8	5	2	0	0.655	1.000	1.000
139	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(8), APOBEC1(1), APOBEC2(1), APOBEC3B(5), APOBEC3C(1), APOBEC3G(1)	5585129	17	17	16	6	3	2	6	5	1	0	0.740	1.000	1.000
140	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	12	CCNA1(7), CCNA2(4), CCND1(3), CCNE1(4), CCNE2(4), CDK4(5), CDKN1B(2), E2F2(3), E2F4(3), PRB1(7)	6412605	42	40	42	13	1	10	12	13	6	0	0.580	1.000	1.000
141	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	15	APAF1(12), ATM(16), BCL2(1), CCND1(3), CCNE1(4), CDK4(5), GADD45A(1), MDM2(3), PCNA(1), RB1(17)	13183801	63	58	63	14	2	15	11	13	22	0	0.254	1.000	1.000
142	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	5	CREBBP(37), ESR1(5), PELP1(2), SRC(1)	6969166	45	39	44	14	4	7	14	9	10	1	0.429	1.000	1.000
143	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CCL2(2), CSF1(2), IL1B(1), MST1R(9)	4965226	14	14	14	9	1	5	7	0	1	0	0.882	1.000	1.000
144	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	18	CSNK2A1(7), ELK1(2), EPO(2), EPOR(1), FOS(6), JAK2(5), JUN(1), MAP2K1(5), MAPK8(4), PLCG1(9), PTPN6(3), RAF1(3), SHC1(2), SOS1(9), STAT5A(3), STAT5B(5)	16022908	67	60	67	14	12	16	25	5	9	0	0.0317	1.000	1.000
145	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	8	CAMK1(2), CAMK1G(2), HDAC9(15), MEF2A(3), MEF2B(5), MEF2D(1), MYOD1(2), YWHAH(2)	5176837	32	30	32	10	7	5	8	9	3	0	0.454	1.000	1.000
146	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	11	ASAH1(1), BRAF(10), CREB1(1), CREB5(7), RAF1(3), SNX13(2), SRC(1), TERF2IP(1)	7971683	26	19	26	9	2	4	9	6	5	0	0.755	1.000	1.000
147	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	22	CDC34(4), TAX1BP3(1), UBE2D2(1), UBE2J1(1), UBE2J2(1), UBE2L3(2), UBE2L6(2), UBE2M(3), UBE2S(1), UBE3A(6)	7246312	22	20	22	8	3	10	5	1	3	0	0.574	1.000	1.000
148	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(14), GNA12(1), PRKACB(3), PRKACG(2), PRKAR2B(3)	7662733	23	22	23	8	3	8	6	3	3	0	0.609	1.000	1.000
149	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNG(2), IL12A(1), IL12B(3), IL13(1), IL16(12), IL18(1), IL1A(1), IL2(2), IL3(1), IL4(1), IL5(2), IL6(2), IL9(2), LTA(4)	7576239	35	33	35	11	7	8	10	6	4	0	0.424	1.000	1.000
150	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	17	AKT1(2), BAD(1), BCL2L1(2), CASP9(1), CDC42(3), CHUK(6), ELK1(2), H2AFX(1), MAP2K1(5), NFKB1(5), PIK3R1(9), RAF1(3), RALBP1(3), RALGDS(6), RELA(2)	11911833	51	44	51	12	10	8	15	4	14	0	0.209	1.000	1.000
151	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	CARM1(5), DHRS1(2), DHRS2(4), DHRS3(1), DHRS7(1), HEMK1(1), LCMT1(2), LCMT2(6), METTL2B(3), METTL6(2), PRMT2(2), PRMT3(6), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(6)	11431730	49	45	49	12	10	13	11	8	7	0	0.0924	1.000	1.000
152	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(2), ALAS2(4), CPOX(1), FECH(1), PPOX(1), UROD(1), UROS(3)	5750455	13	13	13	8	1	3	4	4	1	0	0.935	1.000	1.000
153	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	12	ABL1(8), MDM2(3), MYC(6), PIK3R1(9), POLR1A(9), POLR1B(3), POLR1C(2), RB1(17), TBX2(4), TWIST1(1)	12402108	62	56	59	16	6	8	14	11	23	0	0.380	1.000	1.000
154	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	12	AKT1(2), BAD(1), IGF1R(11), IRS1(2), MAP2K1(5), PIK3R1(9), RAF1(3), SHC1(2), SOS1(9), YWHAH(2)	11949147	46	40	46	11	9	10	13	7	7	0	0.166	1.000	1.000
155	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	7	CREB1(1), PTK2B(4), SHC1(2), SOS1(9), SRC(1)	6387405	17	16	17	8	6	2	5	3	1	0	0.836	1.000	1.000
156	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	8	CISH(1), IFNG(2), IFNGR1(4), JAK1(10), JAK2(5), PLA2G2A(2), PTPRU(10), STAT1(8)	8445306	42	39	41	12	9	13	6	5	9	0	0.158	1.000	1.000
157	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(1), B3GALNT1(1), B3GALT5(1), FUT2(2), FUT9(11), GBGT1(4), GLA(2), HEXA(4), NAGA(4), ST3GAL1(2), ST3GAL2(1), ST8SIA1(3)	8200744	36	33	36	11	7	7	14	4	4	0	0.241	1.000	1.000
158	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	13	AKT1(2), BCAR1(3), CDKN1B(2), ILK(4), ITGB1(15), PDK2(1), PDPK1(4), PIK3R1(9), PTK2(8), SHC1(2), SOS1(9)	11953810	59	49	57	15	8	11	15	8	17	0	0.315	1.000	1.000
159	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	12	CARM1(5), CREB1(1), CREBBP(37), NCOA3(8), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), RARA(5), RXRA(4)	11981192	76	65	75	22	13	19	16	12	15	1	0.236	1.000	1.000
160	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	11	ADAM17(5), APC(27), AXIN1(12), BTRC(1), CTNNB1(6), DLL1(5), DVL1(8), FZD1(6), GSK3B(3), WNT1(2)	13267518	75	55	74	20	15	18	16	13	12	1	0.170	1.000	1.000
161	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(3), F2(3), F2R(4), F3(2), F5(19), F7(2), FGA(12), FGB(4), FGG(6), PROC(2), PROS1(10), SERPINC1(4), TFPI(2)	12478498	73	57	73	19	6	23	21	13	10	0	0.158	1.000	1.000
162	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	20	APAF1(12), ARHGDIB(1), BIRC2(3), BIRC3(2), CASP1(2), CASP10(2), CASP2(3), CASP3(2), CASP4(2), CASP6(5), CASP7(3), CASP9(1), GZMB(2), LMNA(1), LMNB1(2), LMNB2(8), PRF1(5)	13831187	56	48	56	13	9	15	10	13	9	0	0.121	1.000	1.000
163	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(7), CAPN1(3), CAPNS1(2), CAPNS2(2), CDK5(3), CDK5R1(1), CSNK1A1(1), CSNK1D(1), GSK3B(3), MAPT(9)	7035680	32	29	32	10	6	8	10	6	2	0	0.343	1.000	1.000
164	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(8), ACO2(4), AFMID(5), CS(3), GRHPR(1), HAO1(12), HAO2(1), HYI(2), MDH1(1), MDH2(1), MTHFD1(6), MTHFD1L(6), MTHFD2(3)	10194513	53	46	53	16	7	14	18	8	5	1	0.385	1.000	1.000
165	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM1(1), CALM2(2), CALM3(2), CAMK1(2), CAMK1G(2), CAMK2A(2), CAMK2B(3), CAMK2D(3), CAMK2G(2), CAMKK1(1), CAMKK2(6), CREB1(1), SYT1(9)	8808971	36	36	36	11	4	8	13	8	3	0	0.497	1.000	1.000
166	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	14	APAF1(12), BIRC2(3), BIRC3(2), CASP10(2), CASP3(2), CASP7(3), CASP9(1), GZMB(2), PRF1(5), SCAP(8), SREBF1(5), SREBF2(5)	12986829	50	45	50	13	9	13	11	9	8	0	0.209	1.000	1.000
167	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	20	ACTA1(4), ADCY1(21), CAP1(3), CCNB1(2), CDC25C(4), GNAI1(2), GNAS(13), GNB1(3), MYT1(11), PIN1(1), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), RPS6KA1(10), SRC(1)	14844057	91	72	90	23	26	18	24	12	11	0	0.0467	1.000	1.000
168	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	22	CALM1(1), CALM2(2), CALM3(2), CAMK1(2), CAMK1G(2), CAMK2A(2), CAMK2B(3), CAMK2D(3), CAMK2G(2), ESRRA(4), HDAC5(3), MEF2A(3), MEF2B(5), MEF2D(1), PPARA(2), PPP3CA(2), PPP3CB(1), SLC2A4(3), SYT1(9), YWHAH(2)	14751533	54	49	53	14	5	16	17	14	2	0	0.120	1.000	1.000
169	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	10	CISH(1), IL6(2), IL6R(6), JAK1(10), JAK2(5), JAK3(6), PIAS3(4), PTPRU(10), SRC(1), STAT3(6)	11315209	51	50	51	14	13	8	14	10	6	0	0.163	1.000	1.000
170	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(2), B4GALT1(1), B4GALT2(5), FBP2(1), G6PC(2), GAA(3), GALK1(1), GALK2(2), GALT(2), GANAB(4), GCK(4), GLA(2), GLB1(5), HK1(4), HK2(6), HK3(8), LALBA(1), LCT(17), MGAM(29), PFKM(6), PFKP(5), PGM1(5), PGM3(1)	24759228	116	96	115	25	20	29	31	15	20	1	0.00492	1.000	1.000
171	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	23	ABL1(8), ATM(16), ATR(24), CCNA1(7), CCND1(3), CCNE1(4), CDC25A(3), CDK4(5), CDK6(1), CDKN1B(2), DHFR(2), GSK3B(3), HDAC1(1), RB1(17), SKP2(4), TFDP1(2), TGFB1(1), TGFB2(4), TGFB3(1)	21933607	108	94	107	25	9	20	27	24	28	0	0.165	1.000	1.000
172	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(3), CSF1R(2), EGF(8), EGFR(19), MET(4), PDGFRA(13), PRKCA(7), SH3GLB1(1), SH3GLB2(3), SH3KBP1(8), SRC(1)	14777379	69	65	69	20	9	13	23	12	11	1	0.239	1.000	1.000
173	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	19	CSNK2A1(7), FOS(6), JAK2(5), JUN(1), MAP2K1(5), MPL(4), PIK3R1(9), PLCG1(9), PRKCA(7), RAF1(3), SHC1(2), SOS1(9), STAT1(8), STAT3(6), STAT5A(3), STAT5B(5), THPO(1)	19284222	90	75	90	21	13	21	27	11	18	0	0.0628	1.000	1.000
174	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(8), EGFR(19), MAP2K1(5), MAP3K1(6), MAPK14(2), NCOR2(22), RARA(5), RXRA(4), THRA(5), THRB(1)	13159977	77	65	77	22	13	11	23	15	14	1	0.254	1.000	1.000
175	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	10	AKT1(2), KLK2(2), NTRK1(3), PIK3R1(9), PLCG1(9), PRKCA(7), SHC1(2), SOS1(9)	9865585	43	39	43	12	6	9	14	8	6	0	0.409	1.000	1.000
176	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	24	APC(27), ASAH1(1), CASP3(2), CERK(3), CREB1(1), CREB5(7), CXCL2(1), DAG1(5), EPHB2(3), FOS(6), ITPKB(5), JUN(1), MAP2K4(2), MAP2K7(2), MAPK10(4), MAPK8(4), MAPK8IP1(4), MAPK8IP2(2), MAPK8IP3(9), MAPK9(4)	21306365	93	77	92	22	14	25	23	15	16	0	0.0596	1.000	1.000
177	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	14	CHUK(6), CREBBP(37), FADD(3), HDAC3(4), IKBKB(11), NFKB1(5), NFKBIA(1), RELA(2), RIPK1(2), TNFRSF1A(2), TNFRSF1B(2), TRADD(1), TRAF6(3)	13346267	79	71	78	22	11	15	23	15	14	1	0.209	1.000	1.000
178	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(4), KHK(3), LCT(17), MPI(4), PGM1(5), PYGL(9), PYGM(8), TPI1(4)	10161153	54	43	54	17	10	14	14	9	7	0	0.195	1.000	1.000
179	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(4), APAF1(12), BCL2(1), CASP3(2), CASP9(1), DAXX(6), FAS(5), FASLG(1), HSPB2(2), IL1A(1), MAPKAPK3(3)	8624495	38	36	38	12	5	13	9	6	5	0	0.396	1.000	1.000
180	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	185	ACTB(4), ACTG1(3), ACTN1(4), ACTN2(10), ACTN4(6), AKT1(2), AKT2(4), AKT3(6), ARHGAP5(10), BAD(1), BCAR1(3), BCL2(1), BIRC2(3), BIRC3(2), BRAF(10), CAPN2(5), CAV1(1), CCND1(3), CCND2(2), CDC42(3), CHAD(5), COL11A1(67), COL11A2(11), COL1A1(10), COL1A2(22), COL2A1(6), COL3A1(17), COL4A1(10), COL4A2(9), COL4A4(14), COL4A6(4), COL5A1(18), COL5A2(14), COL5A3(12), COL6A1(10), COL6A2(11), COL6A3(26), COL6A6(30), CRK(2), CRKL(3), CTNNB1(6), DIAPH1(7), DOCK1(15), EGF(8), EGFR(19), ELK1(2), ERBB2(12), FARP2(4), FIGF(1), FLNA(24), FLNB(9), FLNC(19), FLT1(17), FN1(18), FYN(4), GSK3B(3), HGF(11), IBSP(4), IGF1(1), IGF1R(11), ILK(4), ITGA1(4), ITGA10(9), ITGA11(9), ITGA2(7), ITGA2B(6), ITGA3(5), ITGA4(14), ITGA5(4), ITGA6(4), ITGA7(8), ITGA9(3), ITGAV(6), ITGB1(15), ITGB3(6), ITGB4(8), ITGB5(1), ITGB6(5), ITGB7(1), ITGB8(5), JUN(1), KDR(14), LAMA1(29), LAMA2(43), LAMA3(19), LAMA4(25), LAMA5(17), LAMB1(9), LAMB2(6), LAMB3(5), LAMB4(19), LAMC1(13), LAMC2(6), LAMC3(9), MAP2K1(5), MAPK10(4), MAPK8(4), MAPK9(4), MET(4), MYL7(2), MYL9(4), MYLK(8), MYLK2(5), PAK1(3), PAK2(8), PAK3(5), PAK4(1), PAK6(5), PAK7(9), PARVB(1), PARVG(2), PDGFB(1), PDGFC(3), PDGFD(7), PDGFRA(13), PDGFRB(9), PDPK1(4), PIK3CB(6), PIK3CD(8), PIK3CG(20), PIK3R1(9), PIK3R2(5), PIK3R3(4), PIK3R5(10), PIP5K1C(2), PPP1CA(1), PPP1R12A(5), PRKCA(7), PRKCG(14), PTK2(8), PXN(2), RAC2(3), RAC3(3), RAF1(3), RAP1B(3), RAPGEF1(5), RELN(50), ROCK1(19), ROCK2(11), SHC1(2), SHC2(5), SHC3(6), SHC4(6), SOS1(9), SOS2(11), SPP1(2), SRC(1), THBS1(8), THBS2(10), THBS3(3), THBS4(7), TLN1(22), TLN2(12), TNC(12), TNN(21), TNR(21), TNXB(25), VASP(1), VAV1(7), VAV2(4), VAV3(4), VCL(5), VEGFB(1), VEGFC(6), VTN(2), VWF(19), ZYX(2)	277738019	1461	416	1449	480	230	310	462	226	227	6	0.160	1.000	1.000
181	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	167	ADCY1(21), ADCY2(28), ADCY3(7), ADCY4(8), ADCY7(6), ADCY8(28), ADCY9(9), ADORA2A(3), ADORA2B(1), ADRA1A(5), ADRA1B(3), ADRA1D(3), ADRB1(3), ADRB3(2), ATP2A1(9), ATP2A2(7), ATP2A3(7), ATP2B1(6), ATP2B2(6), ATP2B3(14), ATP2B4(6), AVPR1A(9), AVPR1B(6), BDKRB1(2), BDKRB2(3), BST1(2), CACNA1A(14), CACNA1B(13), CACNA1C(23), CACNA1D(21), CACNA1E(24), CACNA1F(11), CACNA1G(20), CACNA1H(13), CACNA1I(12), CACNA1S(15), CALM1(1), CALM2(2), CALM3(2), CALML3(1), CAMK2A(2), CAMK2B(3), CAMK2D(3), CAMK2G(2), CCKAR(5), CCKBR(3), CD38(5), CHRM2(5), CHRM3(9), CHRM5(4), CHRNA7(2), CYSLTR1(2), CYSLTR2(6), DRD1(2), EDNRA(2), EDNRB(7), EGFR(19), ERBB2(12), ERBB3(17), ERBB4(22), F2R(4), GNA11(4), GNA14(3), GNA15(4), GNAL(4), GNAS(13), GRIN1(4), GRIN2A(21), GRIN2C(7), GRIN2D(6), GRM1(28), GRM5(12), GRPR(1), HRH1(1), HRH2(3), HTR2A(5), HTR2B(2), HTR2C(4), HTR4(2), HTR5A(9), HTR6(6), HTR7(8), ITPKB(5), ITPR1(15), ITPR2(25), ITPR3(10), LHCGR(9), LTB4R2(2), MYLK(8), MYLK2(5), NOS1(9), NOS3(4), NTSR1(3), OXTR(3), P2RX1(4), P2RX2(1), P2RX3(3), P2RX4(3), P2RX5(2), P2RX7(1), PDE1A(6), PDE1B(4), PDE1C(14), PDGFRA(13), PDGFRB(9), PHKA1(3), PHKA2(10), PHKB(2), PHKG1(3), PHKG2(2), PLCB1(22), PLCB2(6), PLCB3(9), PLCB4(16), PLCD1(5), PLCD3(2), PLCD4(3), PLCE1(22), PLCG1(9), PLCG2(9), PLCZ1(7), PPP3CA(2), PPP3CB(1), PRKACA(4), PRKACB(3), PRKACG(2), PRKCA(7), PRKCG(14), PRKX(1), PTGER3(6), PTGFR(2), PTK2B(4), RYR1(34), RYR2(76), RYR3(37), SLC25A6(4), SLC8A1(14), SLC8A2(6), SLC8A3(15), SPHK2(3), TACR1(4), TACR2(4), TACR3(5), TBXA2R(1), TNNC2(1), TRHR(5), TRPC1(10)	204660483	1212	394	1206	419	259	257	345	195	155	1	0.00657	1.000	1.000
182	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	233	ADCYAP1R1(6), ADORA1(3), ADORA2A(3), ADORA2B(1), ADORA3(3), ADRA1A(5), ADRA1B(3), ADRA2B(3), ADRA2C(3), ADRB1(3), ADRB3(2), AGTR2(2), AVPR1A(9), AVPR1B(6), AVPR2(2), BDKRB1(2), BDKRB2(3), BRS3(4), C3AR1(5), C5AR1(2), CALCR(4), CALCRL(5), CCKAR(5), CCKBR(3), CGA(1), CHRM2(5), CHRM3(9), CHRM4(2), CHRM5(4), CNR1(3), CRHR1(3), CRHR2(4), CTSG(1), CYSLTR1(2), CYSLTR2(6), DRD1(2), DRD2(4), DRD3(6), DRD4(1), DRD5(8), EDNRA(2), EDNRB(7), F2(3), F2R(4), F2RL1(1), F2RL2(2), F2RL3(3), FPR1(6), FSHB(2), FSHR(12), GABBR1(4), GABBR2(6), GABRA1(12), GABRA2(12), GABRA3(6), GABRA4(4), GABRA5(6), GABRA6(6), GABRB1(6), GABRB2(7), GABRB3(13), GABRD(2), GABRE(9), GABRG1(11), GABRG2(8), GABRG3(6), GABRP(5), GABRQ(9), GABRR1(4), GABRR2(3), GALR1(3), GALR2(4), GALR3(2), GH1(4), GH2(4), GHR(9), GHRHR(3), GHSR(3), GIPR(2), GLP1R(1), GLP2R(5), GLRA1(4), GLRA2(5), GLRA3(3), GLRB(4), GNRHR(2), GPR156(5), GPR35(2), GPR50(7), GPR63(6), GPR83(1), GRIA1(16), GRIA2(16), GRIA3(8), GRIA4(11), GRID1(20), GRID2(19), GRIK1(8), GRIK2(16), GRIK3(7), GRIK4(6), GRIK5(8), GRIN1(4), GRIN2A(21), GRIN2B(22), GRIN2C(7), GRIN2D(6), GRIN3A(17), GRIN3B(5), GRM1(28), GRM2(9), GRM3(28), GRM4(2), GRM5(12), GRM6(4), GRM7(20), GRM8(24), GRPR(1), GZMA(2), HCRTR1(3), HCRTR2(7), HRH1(1), HRH2(3), HRH3(3), HRH4(3), HTR1A(9), HTR1B(8), HTR1D(2), HTR1E(8), HTR1F(4), HTR2A(5), HTR2B(2), HTR2C(4), HTR4(2), HTR5A(9), HTR6(6), HTR7(8), LEP(1), LEPR(17), LHB(2), LHCGR(9), LTB4R(3), LTB4R2(2), MAS1(2), MC1R(3), MC2R(6), MC3R(2), MC4R(4), MC5R(9), MCHR1(2), MCHR2(4), MLNR(4), MTNR1A(3), MTNR1B(3), NMBR(3), NMUR1(5), NMUR2(1), NPBWR2(4), NPY1R(5), NPY2R(5), NPY5R(8), NR3C1(6), NTSR1(3), NTSR2(6), OPRD1(2), OPRK1(6), OPRL1(6), OPRM1(5), OXTR(3), P2RX1(4), P2RX2(1), P2RX3(3), P2RX4(3), P2RX5(2), P2RX7(1), P2RY1(5), P2RY10(5), P2RY13(2), P2RY14(1), P2RY2(3), P2RY6(1), P2RY8(3), PARD3(14), PRL(3), PRLHR(5), PRLR(9), PRSS1(9), PRSS3(1), PTGDR(3), PTGER2(5), PTGER3(6), PTGER4(8), PTGFR(2), PTGIR(3), PTH2R(11), RXFP1(6), RXFP2(9), SCTR(2), SSTR1(8), SSTR2(3), SSTR3(6), SSTR4(6), SSTR5(2), TAAR1(5), TAAR2(2), TAAR5(1), TAAR6(1), TAAR8(1), TACR1(4), TACR2(4), TACR3(5), TBXA2R(1), THRA(5), THRB(1), TRHR(5), TRPV1(6), TSHB(2), TSHR(4), UTS2R(3), VIPR1(1), VIPR2(5)	167780230	1197	389	1189	432	212	225	397	200	162	1	0.0497	1.000	1.000
183	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	240	ACVR1B(5), ACVR1C(8), AKT1(2), AKT2(4), AKT3(6), ARRB1(1), ARRB2(1), ATF2(1), ATF4(5), BDNF(2), BRAF(10), CACNA1A(14), CACNA1B(13), CACNA1C(23), CACNA1D(21), CACNA1E(24), CACNA1F(11), CACNA1G(20), CACNA1H(13), CACNA1I(12), CACNA1S(15), CACNA2D1(21), CACNA2D2(3), CACNA2D3(2), CACNA2D4(7), CACNB1(4), CACNB2(6), CACNB3(3), CACNB4(2), CACNG1(1), CACNG2(3), CACNG3(3), CACNG4(7), CACNG5(3), CACNG6(5), CACNG7(5), CACNG8(7), CASP3(2), CD14(1), CDC25B(4), CDC42(3), CHUK(6), CRK(2), CRKL(3), DAXX(6), DUSP1(2), DUSP10(3), DUSP14(4), DUSP16(6), DUSP2(1), DUSP3(1), DUSP4(1), DUSP5(4), DUSP6(5), DUSP7(3), DUSP8(1), DUSP9(1), ECSIT(3), EGF(8), EGFR(19), ELK1(2), ELK4(3), FAS(5), FASLG(1), FGF1(3), FGF10(2), FGF11(1), FGF12(6), FGF13(3), FGF14(1), FGF17(2), FGF19(3), FGF2(1), FGF20(1), FGF21(2), FGF23(8), FGF3(1), FGF5(3), FGF6(1), FGF7(1), FGF8(2), FGF9(1), FGFR1(1), FGFR2(3), FGFR3(13), FGFR4(5), FLNA(24), FLNB(9), FLNC(19), FOS(6), GADD45A(1), GADD45G(1), GNA12(1), GNG12(1), IKBKB(11), IL1A(1), IL1B(1), IL1R1(4), IL1R2(1), JUN(1), JUND(1), KRAS(1), MAP2K1(5), MAP2K2(6), MAP2K3(5), MAP2K4(2), MAP2K5(3), MAP2K6(1), MAP2K7(2), MAP3K1(6), MAP3K10(5), MAP3K12(8), MAP3K13(15), MAP3K2(2), MAP3K3(2), MAP3K4(14), MAP3K5(6), MAP3K6(7), MAP3K7(8), MAP3K8(4), MAP4K1(5), MAP4K2(2), MAP4K3(6), MAP4K4(4), MAPK10(4), MAPK11(3), MAPK12(3), MAPK13(3), MAPK14(2), MAPK7(6), MAPK8(4), MAPK8IP1(4), MAPK8IP2(2), MAPK8IP3(9), MAPK9(4), MAPKAPK3(3), MAPKAPK5(2), MAPT(9), MAX(1), MKNK1(1), MKNK2(2), MOS(7), MYC(6), NF1(14), NFATC2(15), NFATC4(3), NFKB1(5), NFKB2(5), NLK(1), NR4A1(2), NRAS(1), NTF3(1), NTRK1(3), NTRK2(3), PAK1(3), PAK2(8), PDGFB(1), PDGFRA(13), PDGFRB(9), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PPM1A(4), PPM1B(3), PPP3CA(2), PPP3CB(1), PPP5C(4), PRKACA(4), PRKACB(3), PRKACG(2), PRKCA(7), PRKCG(14), PRKX(1), PTPN5(1), PTPN7(4), PTPRR(5), RAC2(3), RAC3(3), RAF1(3), RAP1B(3), RAPGEF2(4), RASA2(7), RASGRF1(17), RASGRF2(12), RASGRP1(8), RASGRP2(7), RASGRP3(9), RASGRP4(3), RPS6KA1(10), RPS6KA2(6), RPS6KA3(4), RPS6KA4(3), RPS6KA5(5), RPS6KA6(8), RRAS(2), RRAS2(2), SOS1(9), SOS2(11), SRF(1), STK3(3), STK4(2), TAOK1(5), TAOK2(11), TAOK3(5), TGFB1(1), TGFB2(4), TGFB3(1), TGFBR1(2), TNFRSF1A(2), TRAF2(2), TRAF6(3), ZAK(5)	213015419	1078	388	1068	359	215	227	313	158	163	2	0.0360	1.000	1.000
184	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	197	ABI2(3), ACTN1(4), ACTN2(10), ACTN4(6), APC(27), APC2(6), ARAF(3), ARHGEF1(8), ARHGEF12(11), ARHGEF4(5), ARHGEF6(7), ARHGEF7(2), ARPC1B(3), ARPC2(2), ARPC3(1), ARPC4(1), BAIAP2(2), BCAR1(3), BDKRB1(2), BDKRB2(3), BRAF(10), CD14(1), CDC42(3), CFL1(2), CHRM2(5), CHRM3(9), CHRM4(2), CHRM5(4), CRK(2), CRKL(3), CSK(1), CYFIP1(8), CYFIP2(8), DIAPH1(7), DIAPH2(10), DIAPH3(12), DOCK1(15), EGF(8), EGFR(19), F2(3), F2R(4), FGD1(11), FGD3(5), FGF1(3), FGF10(2), FGF11(1), FGF12(6), FGF13(3), FGF14(1), FGF17(2), FGF19(3), FGF2(1), FGF20(1), FGF21(2), FGF23(8), FGF3(1), FGF5(3), FGF6(1), FGF7(1), FGF8(2), FGF9(1), FGFR1(1), FGFR2(3), FGFR3(13), FGFR4(5), FN1(18), GIT1(5), GNA12(1), GNA13(2), GNG12(1), GSN(5), IQGAP1(11), IQGAP2(7), IQGAP3(10), ITGA1(4), ITGA10(9), ITGA11(9), ITGA2(7), ITGA2B(6), ITGA3(5), ITGA4(14), ITGA5(4), ITGA6(4), ITGA7(8), ITGA9(3), ITGAD(8), ITGAE(4), ITGAL(8), ITGAM(8), ITGAV(6), ITGAX(8), ITGB1(15), ITGB2(3), ITGB3(6), ITGB4(8), ITGB5(1), ITGB6(5), ITGB7(1), ITGB8(5), KRAS(1), LIMK1(5), LIMK2(6), MAP2K1(5), MAP2K2(6), MOS(7), MSN(3), MYH10(24), MYH14(7), MYH9(23), MYL7(2), MYL9(4), MYLK(8), MYLK2(5), NCKAP1(8), NCKAP1L(7), NRAS(1), PAK1(3), PAK2(8), PAK3(5), PAK4(1), PAK6(5), PAK7(9), PDGFB(1), PDGFRA(13), PDGFRB(9), PFN1(1), PFN2(1), PFN4(1), PIK3CB(6), PIK3CD(8), PIK3CG(20), PIK3R1(9), PIK3R2(5), PIK3R3(4), PIK3R5(10), PIP4K2B(3), PIP4K2C(3), PIP5K1A(3), PIP5K1B(9), PIP5K1C(2), PPP1CA(1), PPP1R12A(5), PPP1R12B(4), PTK2(8), PXN(2), RAC2(3), RAC3(3), RAF1(3), RDX(1), ROCK1(19), ROCK2(11), RRAS(2), RRAS2(2), SCIN(5), SLC9A1(4), SOS1(9), SOS2(11), SSH1(6), SSH2(7), SSH3(4), TIAM1(15), TIAM2(14), TMSB4Y(1), VAV1(7), VAV2(4), VAV3(4), VCL(5), WAS(2), WASF1(3), WASF2(5), WASL(2)	205786228	977	370	965	352	180	195	286	158	156	2	0.657	1.000	1.000
185	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	135	ACTB(4), ACTG1(3), CHAD(5), COL11A1(67), COL11A2(11), COL17A1(11), COL1A1(10), COL1A2(22), COL2A1(6), COL3A1(17), COL4A1(10), COL4A2(9), COL4A4(14), COL4A6(4), COL5A1(18), COL5A2(14), COL5A3(12), COL6A1(10), COL6A2(11), COL6A3(26), COL6A6(30), DES(3), DSC1(4), DSC2(8), DSC3(1), DSG1(8), DSG2(4), DSG3(2), DSG4(5), FN1(18), GJA1(2), GJA10(8), GJA3(2), GJA4(1), GJA5(6), GJA8(7), GJA9(2), GJB3(1), GJB4(2), GJB7(1), GJC1(4), GJC3(2), GJD2(2), IBSP(4), ITGA6(4), ITGB4(8), KRT1(2), KRT10(5), KRT12(8), KRT13(4), KRT14(12), KRT15(2), KRT16(2), KRT18(1), KRT19(1), KRT2(3), KRT20(1), KRT23(3), KRT24(6), KRT25(6), KRT27(3), KRT28(6), KRT3(8), KRT31(3), KRT32(2), KRT33A(4), KRT33B(4), KRT34(5), KRT35(4), KRT36(5), KRT37(2), KRT38(5), KRT39(5), KRT4(6), KRT40(5), KRT5(11), KRT6A(4), KRT6B(2), KRT6C(3), KRT7(2), KRT71(4), KRT72(5), KRT73(4), KRT74(8), KRT75(5), KRT76(3), KRT77(3), KRT78(8), KRT79(3), KRT8(1), KRT82(6), KRT83(6), KRT84(1), KRT85(6), KRT86(4), KRT9(3), LAMA1(29), LAMA2(43), LAMA3(19), LAMA4(25), LAMA5(17), LAMB1(9), LAMB2(6), LAMB3(5), LAMB4(19), LAMC1(13), LAMC2(6), LAMC3(9), LMNA(1), LMNB1(2), LMNB2(8), NES(13), RELN(50), SPP1(2), THBS1(8), THBS2(10), THBS3(3), THBS4(7), TNC(12), TNN(21), TNR(21), TNXB(25), VIM(4), VTN(2), VWF(19)	189529707	1046	366	1040	356	169	211	356	148	157	5	0.362	1.000	1.000
186	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	121	ABL1(8), ABLIM1(5), ABLIM2(5), ABLIM3(6), ARHGEF12(11), CDC42(3), CDK5(3), CFL1(2), CXCL12(3), CXCR4(2), DCC(27), DPYSL2(4), DPYSL5(6), EFNA1(2), EFNA5(3), EFNB1(4), EFNB2(1), EFNB3(3), EPHA1(8), EPHA3(18), EPHA4(11), EPHA5(25), EPHA6(17), EPHA7(24), EPHA8(6), EPHB1(15), EPHB2(3), EPHB3(9), EPHB4(8), EPHB6(7), FES(7), FYN(4), GNAI1(2), GNAI2(1), GNAI3(1), GSK3B(3), ITGB1(15), KRAS(1), L1CAM(10), LIMK1(5), LIMK2(6), LRRC4C(30), MET(4), NCK1(5), NCK2(7), NFAT5(12), NFATC1(7), NFATC2(15), NFATC3(5), NFATC4(3), NGEF(3), NRAS(1), NRP1(6), NTN1(3), NTN4(2), NTNG1(3), PAK1(3), PAK2(8), PAK3(5), PAK4(1), PAK6(5), PAK7(9), PLXNA1(23), PLXNA2(17), PLXNA3(16), PLXNB1(7), PLXNB2(17), PLXNB3(9), PLXNC1(9), PPP3CA(2), PPP3CB(1), PTK2(8), RAC2(3), RAC3(3), RGS3(10), RHOD(1), ROBO1(12), ROBO2(16), ROBO3(5), ROCK1(19), ROCK2(11), SEMA3A(13), SEMA3C(8), SEMA3D(5), SEMA3E(10), SEMA3F(4), SEMA3G(4), SEMA4A(5), SEMA4B(1), SEMA4C(3), SEMA4D(9), SEMA4F(5), SEMA4G(8), SEMA5A(27), SEMA5B(14), SEMA6A(3), SEMA6B(6), SEMA6C(2), SEMA6D(11), SEMA7A(4), SLIT1(9), SLIT2(26), SLIT3(9), SRGAP1(10), SRGAP2(2), SRGAP3(7), UNC5A(6), UNC5B(9), UNC5C(20), UNC5D(18)	145688612	888	357	881	270	138	182	279	148	139	2	0.00617	1.000	1.000
187	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	84	AGRN(9), CD36(1), CD44(3), CD47(1), CHAD(5), COL11A1(67), COL11A2(11), COL1A1(10), COL1A2(22), COL2A1(6), COL3A1(17), COL4A1(10), COL4A2(9), COL4A4(14), COL4A6(4), COL5A1(18), COL5A2(14), COL5A3(12), COL6A1(10), COL6A2(11), COL6A3(26), COL6A6(30), DAG1(5), FN1(18), FNDC1(15), FNDC3A(11), FNDC4(4), FNDC5(1), GP5(4), GP6(1), GP9(2), HMMR(3), HSPG2(23), IBSP(4), ITGA1(4), ITGA10(9), ITGA11(9), ITGA2(7), ITGA2B(6), ITGA3(5), ITGA4(14), ITGA5(4), ITGA6(4), ITGA7(8), ITGA9(3), ITGAV(6), ITGB1(15), ITGB3(6), ITGB4(8), ITGB5(1), ITGB6(5), ITGB7(1), ITGB8(5), LAMA1(29), LAMA2(43), LAMA3(19), LAMA4(25), LAMA5(17), LAMB1(9), LAMB2(6), LAMB3(5), LAMB4(19), LAMC1(13), LAMC2(6), LAMC3(9), RELN(50), SDC1(2), SDC2(2), SDC3(2), SDC4(1), SPP1(2), SV2A(5), SV2B(3), SV2C(4), THBS1(8), THBS2(10), THBS3(3), THBS4(7), TNC(12), TNN(21), TNR(21), TNXB(25), VTN(2), VWF(19)	169557748	920	350	915	315	146	195	296	141	138	4	0.475	1.000	1.000
188	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(21), ADCY2(28), ADCY3(7), ADCY4(8), ADCY5(9), ADCY6(6), ADCY7(6), ADCY8(28), ADCY9(9), ADRA1A(5), ADRA1B(3), ADRA1D(3), ADRB1(3), ADRB3(2), ANXA6(6), ARRB1(1), ARRB2(1), ATP1A4(5), ATP1B1(2), ATP1B2(2), ATP1B3(4), ATP2A2(7), ATP2A3(7), ATP2B1(6), ATP2B2(6), ATP2B3(14), CACNA1A(14), CACNA1B(13), CACNA1C(23), CACNA1D(21), CACNA1E(24), CACNA1S(15), CACNB1(4), CACNB3(3), CALM1(1), CALM2(2), CALM3(2), CALR(2), CAMK1(2), CAMK2A(2), CAMK2B(3), CAMK2D(3), CAMK2G(2), CASQ1(3), CASQ2(4), CHRM2(5), CHRM3(9), CHRM4(2), CHRM5(4), GJA1(2), GJA4(1), GJA5(6), GJB3(1), GJB4(2), GNA11(4), GNAI2(1), GNAI3(1), GNAO1(1), GNAZ(6), GNB1(3), GNB2(4), GNB3(6), GNB4(2), GNB5(2), GNG12(1), GNG13(2), GNG2(1), GRK4(1), GRK5(7), ITPR1(15), ITPR2(25), ITPR3(10), KCNB1(3), KCNJ3(9), KCNJ5(3), MIB1(5), NME7(4), PEA15(1), PKIG(1), PLCB3(9), PRKACA(4), PRKACB(3), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), PRKCA(7), PRKCD(4), PRKCE(3), PRKCG(14), PRKCH(4), PRKCQ(8), PRKCZ(3), PRKD1(15), RGS1(3), RGS11(2), RGS14(2), RGS16(1), RGS17(4), RGS18(4), RGS19(2), RGS2(1), RGS20(4), RGS3(10), RGS4(2), RGS5(3), RGS6(5), RGS7(17), RGS9(6), RYR1(34), RYR2(76), RYR3(37), SFN(7), SLC8A1(14), SLC8A3(15), USP5(5), YWHAB(2), YWHAH(2), YWHAQ(3)	142816320	838	346	834	297	177	191	229	130	109	2	0.0383	1.000	1.000
189	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	128	ACTB(4), ACTG1(3), ACTN1(4), ACTN2(10), ACTN4(6), AKT1(2), AKT2(4), AKT3(6), AMOTL1(6), ASH1L(20), CASK(4), CDC42(3), CDK4(5), CGN(7), CLDN10(4), CLDN11(1), CLDN15(3), CLDN16(6), CLDN17(3), CLDN18(3), CLDN2(2), CLDN22(2), CLDN23(1), CLDN4(1), CLDN6(2), CLDN7(1), CLDN8(1), CLDN9(1), CRB3(2), CSNK2A1(7), CSNK2A2(4), CSNK2B(2), CTNNA1(8), CTNNA2(31), CTNNA3(14), CTNNB1(6), CTTN(10), EPB41(4), EPB41L1(7), EPB41L2(12), EPB41L3(23), EXOC3(3), EXOC4(15), F11R(1), GNAI1(2), GNAI2(1), GNAI3(1), HCLS1(1), IGSF5(4), INADL(11), JAM2(2), KRAS(1), LLGL1(2), LLGL2(6), MAGI1(13), MAGI2(20), MAGI3(14), MLLT4(13), MPDZ(15), MPP5(8), MYH1(22), MYH10(24), MYH11(11), MYH13(27), MYH14(7), MYH15(13), MYH2(26), MYH3(15), MYH4(18), MYH6(19), MYH7(16), MYH7B(6), MYH8(26), MYH9(23), MYL7(2), MYL9(4), NRAS(1), OCLN(1), PARD3(14), PARD6A(1), PARD6B(1), PARD6G(6), PPP2CB(3), PPP2R1A(3), PPP2R1B(4), PPP2R2A(2), PPP2R2B(5), PPP2R2C(1), PPP2R3A(12), PPP2R3B(5), PPP2R4(2), PRKCA(7), PRKCD(4), PRKCE(3), PRKCG(14), PRKCH(4), PRKCI(3), PRKCQ(8), PRKCZ(3), RAB13(2), RRAS(2), RRAS2(2), SPTAN1(23), SRC(1), SYMPK(7), TJAP1(4), TJP1(13), TJP2(5), TJP3(6), VAPA(1), YES1(2), ZAK(5)	146717716	817	330	805	261	135	185	251	129	115	2	0.0512	1.000	1.000
190	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ACTA1(4), ACTA2(3), ADCY1(21), ADCY2(28), ADCY3(7), ADCY4(8), ADCY5(9), ADCY6(6), ADCY7(6), ADCY8(28), ADCY9(9), ADM(1), ARRB1(1), ARRB2(1), ATF1(3), ATF2(1), ATF4(5), ATF5(2), ATP2A2(7), ATP2A3(7), CACNB3(3), CALCA(1), CALM1(1), CALM2(2), CALM3(2), CAMK2A(2), CAMK2B(3), CAMK2D(3), CAMK2G(2), CNN1(1), CNN2(1), CORIN(6), CRH(1), CRHR1(3), DGKZ(7), ETS2(7), FOS(6), GABPA(3), GABPB2(1), GBA2(6), GJA1(2), GNB1(3), GNB2(4), GNB3(6), GNB4(2), GNB5(2), GNG12(1), GNG13(2), GNG2(1), GRK4(1), GRK5(7), GSTO1(2), GUCY1A3(9), IGFBP1(3), IGFBP2(1), IGFBP3(1), IGFBP4(2), IL1B(1), IL6(2), ITPR1(15), ITPR2(25), ITPR3(10), JUN(1), MIB1(5), MYL4(2), MYLK2(5), NFKB1(5), NOS1(9), NOS3(4), OXTR(3), PDE4B(7), PDE4D(6), PKIG(1), PLCB3(9), PLCD1(5), PLCG1(9), PLCG2(9), PRKACA(4), PRKACB(3), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), PRKCA(7), PRKCD(4), PRKCE(3), PRKCH(4), PRKCQ(8), PRKCZ(3), PRKD1(15), RAMP1(1), RAMP3(1), RGS1(3), RGS11(2), RGS14(2), RGS16(1), RGS17(4), RGS18(4), RGS19(2), RGS2(1), RGS20(4), RGS3(10), RGS4(2), RGS5(3), RGS6(5), RGS7(17), RGS9(6), RYR1(34), RYR2(76), RYR3(37), SFN(7), SLC8A1(14), SP1(3), TNXB(25), USP5(5), YWHAB(2), YWHAH(2), YWHAQ(3)	131871121	738	329	735	253	141	178	209	115	93	2	0.0430	1.000	1.000
191	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	249	ACVR1(4), ACVR1B(5), ACVR2A(1), ACVR2B(1), AMHR2(1), BMP2(5), BMP7(3), BMPR1B(4), BMPR2(6), CCL1(4), CCL15(1), CCL16(1), CCL2(2), CCL20(1), CCL23(3), CCL24(1), CCL25(3), CCL28(1), CCL3(1), CCL4(1), CCL8(3), CCR1(1), CCR2(4), CCR3(5), CCR4(4), CCR6(2), CCR7(2), CCR9(2), CD27(3), CD40(7), CD40LG(4), CNTFR(1), CRLF2(3), CSF1(2), CSF1R(2), CSF2RA(1), CSF2RB(7), CSF3R(3), CX3CL1(4), CX3CR1(1), CXCL1(3), CXCL10(3), CXCL12(3), CXCL13(1), CXCL14(1), CXCL2(1), CXCL3(1), CXCL5(1), CXCL6(1), CXCL9(3), CXCR3(1), CXCR4(2), EDA(3), EDA2R(1), EDAR(2), EGF(8), EGFR(19), EPO(2), EPOR(1), FAS(5), FASLG(1), FLT1(17), FLT3(6), FLT3LG(1), FLT4(14), GDF5(4), GH1(4), GH2(4), GHR(9), HGF(11), IFNA10(1), IFNA14(1), IFNA16(4), IFNA17(3), IFNA2(1), IFNA21(2), IFNA4(3), IFNA6(1), IFNA8(3), IFNAR1(2), IFNAR2(2), IFNG(2), IFNGR1(4), IFNGR2(4), IFNK(1), IFNW1(2), IL10RA(5), IL10RB(1), IL11RA(2), IL12A(1), IL12B(3), IL12RB1(3), IL12RB2(10), IL13(1), IL13RA1(2), IL17A(3), IL17B(1), IL17RA(7), IL17RB(4), IL18(1), IL18R1(3), IL18RAP(6), IL19(5), IL1A(1), IL1B(1), IL1R1(4), IL1R2(1), IL1RAP(6), IL2(2), IL20RA(3), IL21(3), IL21R(5), IL22(3), IL22RA1(4), IL22RA2(1), IL23R(2), IL24(2), IL25(1), IL26(2), IL2RA(2), IL2RB(3), IL3(1), IL3RA(5), IL4(1), IL4R(8), IL5(2), IL5RA(3), IL6(2), IL6R(6), IL6ST(5), IL7(2), IL7R(6), IL9(2), IL9R(6), INHBA(3), INHBB(4), INHBC(3), INHBE(1), KDR(14), KIT(12), KITLG(1), LEP(1), LEPR(17), LIF(2), LIFR(13), LTA(4), LTBR(6), MET(4), MPL(4), NGFR(1), OSMR(3), PDGFB(1), PDGFC(3), PDGFRA(13), PDGFRB(9), PF4V1(1), PLEKHO2(2), PPBP(1), PRL(3), PRLR(9), RELT(5), TGFB1(1), TGFB2(4), TGFB3(1), TGFBR1(2), TNFRSF10A(3), TNFRSF10B(1), TNFRSF10D(1), TNFRSF11A(3), TNFRSF11B(2), TNFRSF13B(1), TNFRSF13C(2), TNFRSF14(1), TNFRSF19(4), TNFRSF1A(2), TNFRSF1B(2), TNFRSF21(6), TNFRSF25(2), TNFRSF4(2), TNFRSF6B(4), TNFRSF8(2), TNFRSF9(4), TNFSF10(1), TNFSF11(1), TNFSF13(1), TNFSF13B(3), TNFSF14(2), TNFSF15(1), TNFSF18(1), TNFSF4(3), TNFSF8(2), TNFSF9(1), TPO(12), TSLP(3), VEGFB(1), VEGFC(6), XCL1(1), XCL2(1), XCR1(3)	134146762	665	307	661	223	104	125	212	119	104	1	0.288	1.000	1.000
192	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	139	APC(27), APC2(6), AXIN1(12), AXIN2(7), BTRC(1), CACYBP(5), CAMK2A(2), CAMK2B(3), CAMK2D(3), CAMK2G(2), CCND1(3), CCND2(2), CER1(1), CHD8(18), CREBBP(37), CSNK1A1(1), CSNK1A1L(4), CSNK1E(6), CSNK2A1(7), CSNK2A2(4), CSNK2B(2), CTBP1(2), CTBP2(2), CTNNB1(6), CUL1(11), CXXC4(3), DAAM1(8), DAAM2(16), DKK1(2), DKK2(5), DVL1(8), DVL2(1), DVL3(9), FBXW11(3), FOSL1(3), FZD1(6), FZD10(5), FZD2(4), FZD3(2), FZD4(2), FZD5(1), FZD6(6), FZD7(2), FZD8(2), FZD9(2), GSK3B(3), JUN(1), LEF1(5), LRP5(9), LRP6(17), MAP3K7(8), MAPK10(4), MAPK8(4), MAPK9(4), MMP7(1), MYC(6), NFAT5(12), NFATC1(7), NFATC2(15), NFATC3(5), NFATC4(3), NKD1(8), NKD2(3), NLK(1), PLCB1(22), PLCB2(6), PLCB3(9), PLCB4(16), PORCN(3), PPARD(3), PPP2CB(3), PPP2R1A(3), PPP2R1B(4), PPP2R2A(2), PPP2R2B(5), PPP2R2C(1), PPP3CA(2), PPP3CB(1), PRICKLE1(8), PRICKLE2(7), PRKACA(4), PRKACB(3), PRKACG(2), PRKCA(7), PRKCG(14), PRKX(1), RAC2(3), RAC3(3), RBX1(3), ROCK1(19), ROCK2(11), SENP2(3), SFRP1(2), SFRP4(11), SFRP5(1), SIAH1(4), SKP1(1), SMAD2(4), SMAD3(4), SOX17(2), TBL1X(6), TBL1XR1(4), TBL1Y(3), TCF7(2), TCF7L1(2), TCF7L2(1), VANGL1(1), VANGL2(6), WIF1(1), WNT1(2), WNT10A(2), WNT11(2), WNT16(3), WNT2(3), WNT2B(1), WNT3(4), WNT3A(1), WNT4(2), WNT5A(3), WNT5B(1), WNT6(2), WNT7A(3), WNT7B(1), WNT8A(2), WNT8B(4), WNT9A(6), WNT9B(3)	117477161	648	296	642	199	108	134	200	108	96	2	0.0230	1.000	1.000
193	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	140	ADA(1), ADCY1(21), ADCY2(28), ADCY3(7), ADCY4(8), ADCY5(9), ADCY6(6), ADCY7(6), ADCY8(28), ADCY9(9), ADK(1), ADSL(4), ADSS(4), ADSSL1(5), AK1(1), AK2(1), AK7(2), ALLC(4), AMPD1(7), AMPD2(1), AMPD3(2), ATIC(5), CANT1(3), DCK(4), ENPP1(10), ENPP3(8), ENTPD1(4), ENTPD2(1), ENTPD3(2), ENTPD4(5), ENTPD5(3), ENTPD6(2), ENTPD8(2), FHIT(1), GART(5), GDA(7), GMPR(1), GMPR2(3), GMPS(7), GUCY1A2(9), GUCY1A3(9), GUCY1B3(6), GUCY2C(9), GUCY2D(9), GUCY2F(8), GUK1(1), HPRT1(2), IMPDH1(3), IMPDH2(1), ITPA(4), NME2(1), NME4(2), NME7(4), NPR1(4), NPR2(8), NT5C1A(2), NT5C1B(7), NT5C2(2), NT5E(1), NUDT2(1), NUDT5(2), NUDT9(1), PAPSS1(6), PAPSS2(6), PDE11A(4), PDE1A(6), PDE1C(14), PDE2A(5), PDE3B(4), PDE4A(5), PDE4B(7), PDE4C(4), PDE4D(6), PDE5A(8), PDE7A(4), PDE7B(1), PDE8A(3), PDE8B(11), PDE9A(3), PFAS(11), PKLR(3), PNPT1(6), POLA1(4), POLA2(2), POLD1(11), POLD2(1), POLD3(4), POLE(11), POLR1A(9), POLR1B(3), POLR1C(2), POLR2A(12), POLR2B(9), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(3), POLR2G(4), POLR2H(1), POLR2I(1), POLR2J(2), POLR2L(3), POLR3A(8), POLR3B(4), POLR3G(1), POLR3GL(2), POLR3H(1), PPAT(3), PRIM1(3), PRIM2(1), PRPS1(3), PRPS1L1(5), PRPS2(2), PRUNE(2), RFC5(2), RRM1(2), RRM2(1), RRM2B(1), XDH(6)	122342095	573	290	570	194	103	121	174	92	83	0	0.295	1.000	1.000
194	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(4), ACTA2(3), ACTN2(10), ACTN4(6), DES(3), DMD(57), MYBPC1(11), MYBPC2(8), MYBPC3(5), MYH3(15), MYH6(19), MYH7(16), MYH8(26), MYL1(1), MYL4(2), MYL9(4), MYOM1(15), NEB(38), TMOD1(2), TNNC2(1), TNNI2(4), TNNI3(1), TNNT1(2), TNNT2(2), TNNT3(2), TPM1(2), TPM2(2), TPM4(1), TTN(371), VIM(4)	103976175	637	288	632	185	87	154	229	98	65	4	0.234	1.000	1.000
195	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	127	ALCAM(7), CADM1(4), CADM3(4), CD2(1), CD22(3), CD226(6), CD274(1), CD276(1), CD28(3), CD34(5), CD4(1), CD40(7), CD40LG(4), CD58(2), CD6(1), CD80(4), CD86(2), CD8A(3), CD8B(2), CDH1(5), CDH15(4), CDH2(6), CDH3(8), CDH4(8), CDH5(7), CLDN10(4), CLDN11(1), CLDN15(3), CLDN16(6), CLDN17(3), CLDN18(3), CLDN2(2), CLDN22(2), CLDN23(1), CLDN4(1), CLDN6(2), CLDN7(1), CLDN8(1), CLDN9(1), CNTN1(9), CNTN2(9), CNTNAP1(9), CNTNAP2(24), CTLA4(2), ESAM(4), F11R(1), GLG1(5), HLA-C(5), HLA-DMB(1), HLA-DOA(2), HLA-DOB(3), HLA-DPB1(1), HLA-DQA2(2), HLA-DQB1(2), HLA-DRA(1), HLA-DRB1(2), HLA-E(1), HLA-F(4), HLA-G(2), ICAM1(6), ICAM2(3), ICAM3(3), ICOS(1), ICOSLG(1), ITGA4(14), ITGA6(4), ITGA9(3), ITGAL(8), ITGAM(8), ITGAV(6), ITGB1(15), ITGB2(3), ITGB7(1), ITGB8(5), JAM2(2), L1CAM(10), MAG(5), MPZ(2), MPZL1(3), NCAM1(6), NCAM2(14), NEGR1(6), NEO1(4), NFASC(7), NLGN1(19), NLGN2(6), NLGN3(4), NRCAM(15), NRXN1(32), NRXN2(10), NRXN3(19), OCLN(1), PDCD1(1), PTPRC(18), PTPRF(16), PTPRM(21), PVR(3), PVRL1(1), PVRL2(3), PVRL3(9), SDC1(2), SDC2(2), SDC3(2), SDC4(1), SELE(7), SELL(2), SELP(16), SELPLG(3), SIGLEC1(12), SPN(3), VCAM1(10), VCAN(32)	109801964	629	286	624	239	99	131	178	114	107	0	0.688	1.000	1.000
196	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	90	ADCY1(21), ADCY2(28), ADCY3(7), ADCY4(8), ADCY5(9), ADCY6(6), ADCY7(6), ADCY8(28), ADCY9(9), ADRB1(3), CSNK1D(1), DRD1(2), DRD2(4), EGF(8), EGFR(19), GJA1(2), GJD2(2), GNA11(4), GNAI1(2), GNAI2(1), GNAI3(1), GNAS(13), GRM1(28), GRM5(12), GUCY1A2(9), GUCY1A3(9), GUCY1B3(6), GUCY2C(9), GUCY2D(9), GUCY2F(8), HTR2A(5), HTR2B(2), HTR2C(4), ITPR1(15), ITPR2(25), ITPR3(10), KRAS(1), MAP2K1(5), MAP2K2(6), MAP2K5(3), MAP3K2(2), MAPK7(6), NPR1(4), NPR2(8), NRAS(1), PDGFB(1), PDGFC(3), PDGFD(7), PDGFRA(13), PDGFRB(9), PLCB1(22), PLCB2(6), PLCB3(9), PLCB4(16), PRKACA(4), PRKACB(3), PRKACG(2), PRKCA(7), PRKCG(14), PRKG1(7), PRKG2(2), PRKX(1), RAF1(3), SOS1(9), SOS2(11), SRC(1), TJP1(13), TUBA1B(5), TUBA3C(10), TUBA3D(3), TUBA3E(6), TUBA4A(1), TUBA8(2), TUBAL3(3), TUBB(2), TUBB1(3), TUBB2A(1), TUBB3(1), TUBB6(4), TUBB8(3)	99856556	578	286	572	176	106	127	171	104	69	1	0.00384	1.000	1.000
197	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	149	AKT1(2), AKT2(4), AKT3(6), BCL2L1(2), CBL(3), CBLB(7), CBLC(1), CCND1(3), CCND2(2), CISH(1), CNTFR(1), CREBBP(37), CRLF2(3), CSF2RA(1), CSF2RB(7), CSF3R(3), EPO(2), EPOR(1), GH1(4), GH2(4), GHR(9), IFNA10(1), IFNA14(1), IFNA16(4), IFNA17(3), IFNA2(1), IFNA21(2), IFNA4(3), IFNA6(1), IFNA8(3), IFNAR1(2), IFNAR2(2), IFNG(2), IFNGR1(4), IFNGR2(4), IFNK(1), IFNW1(2), IL10RA(5), IL10RB(1), IL11RA(2), IL12A(1), IL12B(3), IL12RB1(3), IL12RB2(10), IL13(1), IL13RA1(2), IL13RA2(4), IL19(5), IL2(2), IL20RA(3), IL21(3), IL21R(5), IL22(3), IL22RA1(4), IL22RA2(1), IL23R(2), IL24(2), IL26(2), IL2RA(2), IL2RB(3), IL3(1), IL3RA(5), IL4(1), IL4R(8), IL5(2), IL5RA(3), IL6(2), IL6R(6), IL6ST(5), IL7(2), IL7R(6), IL9(2), IL9R(6), IRF9(2), JAK1(10), JAK2(5), JAK3(6), LEP(1), LEPR(17), LIF(2), LIFR(13), MPL(4), MYC(6), OSMR(3), PIAS1(1), PIAS2(4), PIAS3(4), PIAS4(3), PIK3CB(6), PIK3CD(8), PIK3CG(20), PIK3R1(9), PIK3R2(5), PIK3R3(4), PIK3R5(10), PIM1(3), PRL(3), PRLR(9), PTPN11(2), PTPN6(3), SOCS1(1), SOCS2(1), SOCS3(1), SOCS4(2), SOCS5(6), SOCS7(2), SOS1(9), SOS2(11), SPRED1(3), SPRED2(5), SPRY1(3), SPRY2(4), SPRY3(3), SPRY4(2), STAM(2), STAM2(3), STAT1(8), STAT2(4), STAT3(6), STAT4(6), STAT5A(3), STAT5B(5), STAT6(5), TPO(12), TSLP(3), TYK2(8)	105389273	538	285	530	170	70	108	167	106	86	1	0.163	1.000	1.000
198	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	93	ADCY1(21), ADCY2(28), ADCY3(7), ADCY4(8), ADCY5(9), ADCY6(6), ADCY7(6), ADCY8(28), ADCY9(9), ATF4(5), CACNA1C(23), CACNA1D(21), CACNA1F(11), CACNA1S(15), CALM1(1), CALM2(2), CALM3(2), CALML3(1), CAMK2A(2), CAMK2B(3), CAMK2D(3), CAMK2G(2), CDC42(3), CGA(1), EGFR(19), ELK1(2), FSHB(2), GNA11(4), GNAS(13), GNRHR(2), ITPR1(15), ITPR2(25), ITPR3(10), JUN(1), KRAS(1), LHB(2), MAP2K1(5), MAP2K2(6), MAP2K3(5), MAP2K4(2), MAP2K6(1), MAP2K7(2), MAP3K1(6), MAP3K2(2), MAP3K3(2), MAP3K4(14), MAPK10(4), MAPK11(3), MAPK12(3), MAPK13(3), MAPK14(2), MAPK7(6), MAPK8(4), MAPK9(4), MMP14(4), MMP2(5), NRAS(1), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PLCB1(22), PLCB2(6), PLCB3(9), PLCB4(16), PLD1(15), PLD2(1), PRKACA(4), PRKACB(3), PRKACG(2), PRKCA(7), PRKCD(4), PRKX(1), PTK2B(4), RAF1(3), SOS1(9), SOS2(11), SRC(1)	95902403	532	284	527	176	106	119	153	89	65	0	0.0399	1.000	1.000
199	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	128	ACACA(16), ACACB(18), AKT1(2), AKT2(4), AKT3(6), ARAF(3), BAD(1), BRAF(10), CALM1(1), CALM2(2), CALM3(2), CALML3(1), CBL(3), CBLB(7), CBLC(1), CRK(2), CRKL(3), EIF4EBP1(1), ELK1(2), FASN(10), FBP2(1), FLOT1(2), FLOT2(3), FOXO1(4), G6PC(2), G6PC2(6), GCK(4), GSK3B(3), GYS1(6), GYS2(6), IKBKB(11), INPP5D(8), INSR(3), IRS1(2), IRS2(6), IRS4(16), KRAS(1), LIPE(8), MAP2K1(5), MAP2K2(6), MAPK10(4), MAPK8(4), MAPK9(4), MKNK1(1), MKNK2(2), NRAS(1), PCK1(2), PCK2(4), PDE3A(19), PDE3B(4), PDPK1(4), PFKL(6), PFKM(6), PFKP(5), PHKA1(3), PHKA2(10), PHKB(2), PHKG1(3), PHKG2(2), PIK3CB(6), PIK3CD(8), PIK3CG(20), PIK3R1(9), PIK3R2(5), PIK3R3(4), PIK3R5(10), PKLR(3), PPARGC1A(6), PPP1CA(1), PPP1R3A(14), PPP1R3B(3), PPP1R3C(1), PPP1R3D(3), PRKAA1(4), PRKAA2(5), PRKAB1(4), PRKAB2(1), PRKACA(4), PRKACB(3), PRKACG(2), PRKAG2(2), PRKAG3(3), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), PRKCI(3), PRKCZ(3), PRKX(1), PTPN1(3), PTPRF(16), PYGB(6), PYGL(9), PYGM(8), RAF1(3), RAPGEF1(5), RHEB(1), RHOQ(1), RPS6KB1(4), RPS6KB2(2), SHC1(2), SHC2(5), SHC3(6), SHC4(6), SLC2A4(3), SOCS1(1), SOCS2(1), SOCS3(1), SOCS4(2), SORBS1(7), SOS1(9), SOS2(11), SREBF1(5), TRIP10(6), TSC1(3), TSC2(7)	119627908	556	283	551	184	113	112	152	91	88	0	0.143	1.000	1.000
200	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	160	ADORA1(3), ADORA2A(3), ADORA2B(1), ADORA3(3), ADRA1A(5), ADRA1B(3), ADRA1D(3), ADRA2C(3), ADRB1(3), ADRB3(2), AGTR2(2), AVPR1A(9), AVPR1B(6), AVPR2(2), BDKRB1(2), BDKRB2(3), BRS3(4), C3AR1(5), CCKAR(5), CCKBR(3), CCR1(1), CCR10(2), CCR2(4), CCR3(5), CCR4(4), CCR6(2), CCR7(2), CCR9(2), CCRL2(3), CHML(9), CHRM2(5), CHRM3(9), CHRM4(2), CHRM5(4), CMKLR1(3), CNR1(3), CX3CR1(1), CXCR3(1), CXCR4(2), DRD1(2), DRD2(4), DRD3(6), DRD4(1), DRD5(8), EDNRA(2), EDNRB(7), F2R(4), F2RL1(1), F2RL2(2), F2RL3(3), FPR1(6), FSHR(12), GALR1(3), GALR2(4), GALR3(2), GALT(2), GHSR(3), GNB2L1(1), GPR17(3), GPR173(1), GPR174(4), GPR27(2), GPR3(2), GPR35(2), GPR37(10), GPR37L1(5), GPR4(1), GPR50(7), GPR6(3), GPR63(6), GPR83(1), GRPR(1), HCRTR1(3), HCRTR2(7), HRH1(1), HRH2(3), HRH3(3), HTR1A(9), HTR1B(8), HTR1D(2), HTR1E(8), HTR1F(4), HTR2A(5), HTR2B(2), HTR2C(4), HTR4(2), HTR5A(9), HTR6(6), HTR7(8), LHCGR(9), LTB4R(3), MAS1(2), MC1R(3), MC3R(2), MC4R(4), MC5R(9), MLNR(4), MTNR1A(3), MTNR1B(3), NMBR(3), NMUR1(5), NMUR2(1), NPY1R(5), NPY2R(5), NPY5R(8), NTSR1(3), NTSR2(6), OPN1SW(1), OPN3(3), OPRD1(2), OPRK1(6), OPRL1(6), OPRM1(5), OR10A5(4), OR11A1(3), OR12D3(3), OR1C1(6), OR1F1(2), OR1Q1(2), OR2H1(4), OR5V1(6), OR7A5(7), OR8B8(1), OXTR(3), P2RY1(5), P2RY10(5), P2RY13(2), P2RY14(1), P2RY2(3), P2RY6(1), PTGDR(3), PTGER2(5), PTGER4(8), PTGFR(2), PTGIR(3), RGR(3), RHO(3), RRH(3), SSTR1(8), SSTR2(3), SSTR3(6), SSTR4(6), SUCNR1(1), TBXA2R(1), TRHR(5)	92196187	558	282	555	226	109	116	185	85	63	0	0.152	1.000	1.000
201	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	90	ADCY1(21), ADCY2(28), ADCY3(7), ADCY4(8), ADCY5(9), ADCY6(6), ADCY7(6), ADCY8(28), ADCY9(9), AKAP1(9), AKAP10(5), AKAP11(9), AKAP12(14), AKAP2(14), AKAP3(8), AKAP4(11), AKAP5(5), AKAP6(26), AKAP7(5), AKAP8(3), AKAP9(32), ARHGEF1(8), CALM1(1), CALM2(2), CALM3(2), CHMP1B(2), GNA11(4), GNA12(1), GNA13(2), GNA14(3), GNA15(4), GNAI2(1), GNAI3(1), GNAL(4), GNAO1(1), GNAZ(6), GNB1(3), GNB2(4), GNB3(6), GNB5(2), GNG10(1), GNG12(1), GNG13(2), ITPR1(15), KCNJ3(9), KRAS(1), NRAS(1), PALM2(2), PDE1A(6), PDE1B(4), PDE1C(14), PDE4A(5), PDE4B(7), PDE4C(4), PDE4D(6), PDE7A(4), PDE7B(1), PDE8A(3), PDE8B(11), PLCB3(9), PPP3CA(2), PRKACA(4), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), PRKCA(7), PRKCD(4), PRKCE(3), PRKCG(14), PRKCH(4), PRKCI(3), PRKCQ(8), PRKCZ(3), PRKD1(15), PRKD3(9), RRAS(2), SLC9A1(4), USP5(5)	88391946	529	281	525	151	103	123	143	89	71	0	0.00273	1.000	1.000
202	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	109	ADA(1), ADCY1(21), ADCY2(28), ADCY3(7), ADCY4(8), ADCY5(9), ADCY6(6), ADCY7(6), ADCY8(28), ADK(1), ADSL(4), ADSS(4), AK1(1), AK2(1), ALLC(4), AMPD1(7), AMPD2(1), AMPD3(2), ATIC(5), ATP1B1(2), ATP5A1(1), ATP5B(2), ATP5C1(1), ATP5F1(1), ATP5G1(1), ATP5G2(2), ATP5G3(1), ATP5H(1), ATP5J(2), CANT1(3), DCK(4), ENPP1(10), ENPP3(8), ENTPD1(4), ENTPD2(1), FHIT(1), GART(5), GDA(7), GMPS(7), GUCY1A2(9), GUCY1A3(9), GUCY1B3(6), GUCY2C(9), GUCY2D(9), GUCY2F(8), GUK1(1), HPRT1(2), IMPDH1(3), IMPDH2(1), ITPA(4), NME2(1), NPR1(4), NPR2(8), NT5E(1), NUDT2(1), PAPSS1(6), PAPSS2(6), PDE1A(6), PDE4A(5), PDE4B(7), PDE4C(4), PDE4D(6), PDE5A(8), PDE6B(2), PDE6C(3), PDE7B(1), PDE8A(3), PDE9A(3), PFAS(11), PKLR(3), POLB(1), POLD1(11), POLD2(1), POLE(11), POLG(8), POLL(5), POLQ(23), POLR1B(3), POLR2A(12), POLR2B(9), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(3), POLR2G(4), POLR2H(1), POLR2I(1), POLR2J(2), POLR2L(3), POLRMT(6), PPAT(3), PRPS1(3), PRPS1L1(5), PRPS2(2), PRUNE(2), RRM1(2), RRM2(1)	96901726	483	263	480	152	83	102	156	70	72	0	0.0812	1.000	1.000
203	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	107	ACTN1(4), ACTN2(10), ACTN4(6), ARHGAP5(10), BCAR1(3), CDC42(3), CDH5(7), CLDN10(4), CLDN11(1), CLDN15(3), CLDN16(6), CLDN17(3), CLDN18(3), CLDN2(2), CLDN22(2), CLDN23(1), CLDN4(1), CLDN6(2), CLDN7(1), CLDN8(1), CLDN9(1), CTNNA1(8), CTNNA2(31), CTNNA3(14), CTNNB1(6), CTNND1(8), CXCL12(3), CXCR4(2), CYBB(3), ESAM(4), F11R(1), GNAI1(2), GNAI2(1), GNAI3(1), ICAM1(6), ITGA4(14), ITGAL(8), ITGAM(8), ITGB1(15), ITGB2(3), ITK(3), JAM2(2), MAPK11(3), MAPK12(3), MAPK13(3), MAPK14(2), MLLT4(13), MMP2(5), MMP9(1), MSN(3), MYL7(2), MYL9(4), NCF1(2), NCF2(6), NCF4(2), NOX1(6), NOX3(8), OCLN(1), PIK3CB(6), PIK3CD(8), PIK3CG(20), PIK3R1(9), PIK3R2(5), PIK3R3(4), PIK3R5(10), PLCG1(9), PLCG2(9), PRKCA(7), PRKCG(14), PTK2(8), PTK2B(4), PTPN11(2), PXN(2), RAC2(3), RAP1B(3), RAPGEF3(6), RAPGEF4(1), RASSF5(2), RHOH(1), ROCK1(19), ROCK2(11), SIPA1(3), THY1(2), TXK(6), VASP(1), VAV1(7), VAV2(4), VAV3(4), VCAM1(10), VCL(5)	92539513	486	261	479	173	81	92	133	90	89	1	0.595	1.000	1.000
204	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	96	ADCY1(21), ADCY2(28), ADCY3(7), ADCY4(8), ADCY5(9), ADCY6(6), ADCY7(6), ADCY8(28), ADCY9(9), CALM1(1), CALM2(2), CALM3(2), CALML3(1), CAMK2A(2), CAMK2B(3), CAMK2D(3), CAMK2G(2), CREB1(1), CREB3L1(4), CREB3L2(3), CREB3L3(9), CREB3L4(2), CREBBP(37), CTNNB1(6), DCT(3), DVL1(8), DVL2(1), DVL3(9), EDN1(1), EDNRB(7), FZD1(6), FZD10(5), FZD2(4), FZD3(2), FZD4(2), FZD5(1), FZD6(6), FZD7(2), FZD8(2), FZD9(2), GNAI1(2), GNAI2(1), GNAI3(1), GNAO1(1), GNAS(13), GSK3B(3), KIT(12), KITLG(1), KRAS(1), LEF1(5), MAP2K1(5), MAP2K2(6), MC1R(3), MITF(5), NRAS(1), PLCB1(22), PLCB2(6), PLCB3(9), PLCB4(16), POMC(1), PRKACA(4), PRKACB(3), PRKACG(2), PRKCA(7), PRKCG(14), PRKX(1), RAF1(3), TCF7(2), TCF7L1(2), TCF7L2(1), TYR(8), TYRP1(4), WNT1(2), WNT10A(2), WNT11(2), WNT16(3), WNT2(3), WNT2B(1), WNT3(4), WNT3A(1), WNT4(2), WNT5A(3), WNT5B(1), WNT6(2), WNT7A(3), WNT7B(1), WNT8A(2), WNT8B(4), WNT9A(6), WNT9B(3)	78622772	471	260	466	147	103	86	138	83	59	2	0.00810	1.000	1.000
205	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	82	ABL1(8), ABL2(9), AKT1(2), AKT2(4), AKT3(6), ARAF(3), BAD(1), BRAF(10), BTC(3), CAMK2A(2), CAMK2B(3), CAMK2D(3), CAMK2G(2), CBL(3), CBLB(7), CBLC(1), CDKN1B(2), CRK(2), CRKL(3), EGF(8), EGFR(19), EIF4EBP1(1), ELK1(2), ERBB2(12), ERBB3(17), ERBB4(22), EREG(1), GAB1(5), GSK3B(3), JUN(1), KRAS(1), MAP2K1(5), MAP2K2(6), MAP2K4(2), MAP2K7(2), MAPK10(4), MAPK8(4), MAPK9(4), MYC(6), NCK1(5), NCK2(7), NRAS(1), NRG1(1), NRG2(5), NRG3(19), NRG4(2), PAK1(3), PAK2(8), PAK3(5), PAK4(1), PAK6(5), PAK7(9), PIK3CB(6), PIK3CD(8), PIK3CG(20), PIK3R1(9), PIK3R2(5), PIK3R3(4), PIK3R5(10), PLCG1(9), PLCG2(9), PRKCA(7), PRKCG(14), PTK2(8), RAF1(3), RPS6KB1(4), RPS6KB2(2), SHC1(2), SHC2(5), SHC3(6), SHC4(6), SOS1(9), SOS2(11), SRC(1), STAT5A(3), STAT5B(5)	75986783	436	256	430	138	63	87	142	84	59	1	0.285	1.000	1.000
206	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	69	ACP1(1), ACTB(4), ACTG1(3), ACTN1(4), ACTN2(10), ACTN4(6), ACVR1B(5), ACVR1C(8), BAIAP2(2), CDC42(3), CDH1(5), CREBBP(37), CSNK2A1(7), CSNK2A2(4), CSNK2B(2), CTNNA1(8), CTNNA2(31), CTNNA3(14), CTNNB1(6), CTNND1(8), EGFR(19), ERBB2(12), FARP2(4), FER(6), FGFR1(1), FYN(4), IGF1R(11), INSR(3), IQGAP1(11), LEF1(5), LMO7(7), MAP3K7(8), MET(4), MLLT4(13), NLK(1), PARD3(14), PTPN1(3), PTPN6(3), PTPRB(22), PTPRF(16), PTPRJ(7), PTPRM(21), PVRL1(1), PVRL2(3), PVRL3(9), PVRL4(4), RAC2(3), RAC3(3), SMAD2(4), SMAD3(4), SNAI2(1), SORBS1(7), SRC(1), SSX2IP(6), TCF7(2), TCF7L1(2), TCF7L2(1), TGFBR1(2), TJP1(13), VCL(5), WAS(2), WASF1(3), WASF2(5), WASF3(6), WASL(2), YES1(2)	84554520	454	255	448	145	70	94	131	86	71	2	0.309	1.000	1.000
207	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	64	ADCY1(21), ADCY8(28), ARAF(3), ATF4(5), BRAF(10), CACNA1C(23), CALM1(1), CALM2(2), CALM3(2), CALML3(1), CAMK2A(2), CAMK2B(3), CAMK2D(3), CAMK2G(2), CREBBP(37), GRIA1(16), GRIA2(16), GRIN1(4), GRIN2A(21), GRIN2B(22), GRIN2C(7), GRIN2D(6), GRM1(28), GRM5(12), ITPR1(15), ITPR2(25), ITPR3(10), KRAS(1), MAP2K1(5), MAP2K2(6), NRAS(1), PLCB1(22), PLCB2(6), PLCB3(9), PLCB4(16), PPP1CA(1), PPP1R12A(5), PPP1R1A(1), PPP3CA(2), PPP3CB(1), PRKACA(4), PRKACB(3), PRKACG(2), PRKCA(7), PRKCG(14), PRKX(1), RAF1(3), RAP1B(3), RAPGEF3(6), RPS6KA1(10), RPS6KA2(6), RPS6KA3(4), RPS6KA6(8)	71081181	472	253	467	160	81	109	130	91	60	1	0.0911	1.000	1.000
208	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(5), AMY2A(3), AMY2B(8), ASCC3(13), ATP13A2(2), DDX18(4), DDX19A(2), DDX23(3), DDX4(4), DDX41(5), DDX47(2), DDX50(1), DDX51(3), DDX52(6), DDX54(5), DDX55(3), DDX56(4), DHX58(2), ENPP1(10), ENPP3(8), ENTPD7(4), EP400(20), ERCC2(5), ERCC3(5), G6PC(2), G6PC2(6), GAA(3), GANC(6), GBA(2), GCK(4), GPI(3), GUSB(5), GYS1(6), GYS2(6), HK1(4), HK2(6), HK3(8), IFIH1(7), LYZL1(1), MGAM(29), MOV10L1(5), NUDT5(2), NUDT8(1), PGM1(5), PGM3(1), PYGB(6), PYGL(9), PYGM(8), RAD54B(6), RAD54L(5), RUVBL2(2), SETX(13), SI(59), SKIV2L2(4), SMARCA2(15), SMARCA5(2), UGDH(3), UGP2(2), UGT1A1(5), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A9(1), UGT2A1(6), UGT2A3(6), UGT2B10(11), UGT2B11(9), UGT2B15(4), UGT2B17(4), UGT2B28(6), UGT2B4(13), UGT2B7(7), UXS1(2)	94222153	460	252	455	141	55	88	146	96	74	1	0.370	1.000	1.000
209	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	81	ACVR1(4), ACVR1B(5), ACVRL1(3), AKT1(2), AURKB(4), BMPR2(6), BUB1(6), CDIPT(1), CDKL1(1), CDKL2(2), CDS1(3), CDS2(3), CLK1(3), CLK2(11), CLK4(2), COL4A3BP(7), CSNK2A1(7), CSNK2A2(4), CSNK2B(2), DGKA(4), DGKB(11), DGKD(8), DGKE(5), DGKG(6), DGKH(4), DGKQ(7), DGKZ(7), IMPA1(2), INPP1(2), INPP4A(8), INPP4B(11), INPP5A(3), INPPL1(8), ITPKB(5), MAP3K10(5), MOS(7), NEK1(9), NEK3(1), OCRL(3), PAK4(1), PIK3C2A(6), PIK3C2B(8), PIK3C2G(11), PIK3CB(6), PIK3CG(20), PLCB1(22), PLCB2(6), PLCB3(9), PLCB4(16), PLCD1(5), PLCG1(9), PLCG2(9), PLK3(5), PRKACA(4), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), PRKCA(7), PRKCD(4), PRKCE(3), PRKCG(14), PRKCH(4), PRKCQ(8), PRKCZ(3), PRKD1(15), PRKG1(7), RAF1(3), RPS6KA1(10), RPS6KA2(6), RPS6KA3(4), RPS6KA4(3), RPS6KB1(4), STK11(6), TGFBR1(2), VRK1(1)	84256903	449	249	443	139	82	84	133	71	79	0	0.0951	1.000	1.000
210	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	71	CALM1(1), CALM2(2), CALM3(2), CALML3(1), CDIPT(1), CDS1(3), CDS2(3), DGKA(4), DGKB(11), DGKD(8), DGKE(5), DGKG(6), DGKH(4), DGKI(13), DGKQ(7), DGKZ(7), FN3K(3), IMPA1(2), IMPA2(2), INPP1(2), INPP4A(8), INPP4B(11), INPP5A(3), INPP5B(5), INPP5D(8), INPP5E(1), INPPL1(8), ITPK1(3), ITPKB(5), ITPR1(15), ITPR2(25), ITPR3(10), OCRL(3), PI4KA(7), PI4KB(2), PIK3C2A(6), PIK3C2B(8), PIK3C2G(11), PIK3C3(5), PIK3CB(6), PIK3CD(8), PIK3CG(20), PIK3R1(9), PIK3R2(5), PIK3R3(4), PIK3R5(10), PIP4K2B(3), PIP4K2C(3), PIP5K1A(3), PIP5K1B(9), PIP5K1C(2), PLCB1(22), PLCB2(6), PLCB3(9), PLCB4(16), PLCD1(5), PLCD3(2), PLCD4(3), PLCE1(22), PLCG1(9), PLCG2(9), PLCZ1(7), PRKCA(7), PRKCG(14), PTPMT1(2), SYNJ1(10), SYNJ2(8)	92466944	464	248	458	149	73	98	128	88	77	0	0.108	1.000	1.000
211	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	72	ARAF(3), BRAF(10), CACNA1A(14), CRH(1), CRHR1(3), GNA11(4), GNA12(1), GNA13(2), GNAI1(2), GNAI2(1), GNAI3(1), GNAO1(1), GNAS(13), GNAZ(6), GRIA1(16), GRIA2(16), GRIA3(8), GRID2(19), GRM1(28), GRM5(12), GUCY1A2(9), GUCY1A3(9), GUCY1B3(6), GUCY2C(9), GUCY2D(9), GUCY2F(8), IGF1(1), IGF1R(11), ITPR1(15), ITPR2(25), ITPR3(10), KRAS(1), LYN(8), MAP2K1(5), MAP2K2(6), NOS1(9), NOS3(4), NPR1(4), NPR2(8), NRAS(1), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PLCB1(22), PLCB2(6), PLCB3(9), PLCB4(16), PPP2CB(3), PPP2R1A(3), PPP2R1B(4), PPP2R2A(2), PPP2R2B(5), PPP2R2C(1), PRKCA(7), PRKCG(14), PRKG1(7), PRKG2(2), RAF1(3), RYR1(34)	82942897	474	247	472	152	88	96	139	90	61	0	0.109	1.000	1.000
212	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(15), ABCA10(11), ABCA12(20), ABCA13(41), ABCA2(17), ABCA3(10), ABCA4(14), ABCA5(6), ABCA6(10), ABCA7(9), ABCA8(10), ABCA9(14), ABCB1(19), ABCB11(8), ABCB4(13), ABCB5(10), ABCB6(6), ABCB7(5), ABCB8(6), ABCB9(3), ABCC1(6), ABCC10(9), ABCC11(9), ABCC12(10), ABCC2(9), ABCC3(4), ABCC4(5), ABCC5(9), ABCC6(3), ABCC8(20), ABCC9(29), ABCD1(4), ABCD2(5), ABCD3(4), ABCD4(6), ABCG1(3), ABCG2(4), ABCG4(8), ABCG8(13), CFTR(13), TAP1(6), TAP2(3)	90008118	429	244	426	145	66	88	129	70	76	0	0.153	1.000	1.000
213	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	105	ABL1(8), ANAPC1(8), ANAPC4(2), ANAPC5(1), ANAPC7(1), ATM(16), ATR(24), BUB1(6), BUB1B(6), CCNA1(7), CCNA2(4), CCNB1(2), CCNB3(11), CCND1(3), CCND2(2), CCNE1(4), CCNE2(4), CDC14A(3), CDC14B(1), CDC16(2), CDC20(1), CDC23(4), CDC25A(3), CDC25B(4), CDC25C(4), CDC26(1), CDC27(9), CDC6(2), CDC7(1), CDK4(5), CDK6(1), CDKN1B(2), CDKN2C(1), CDKN2D(1), CHEK1(1), CHEK2(4), CREBBP(37), CUL1(11), DBF4(3), E2F2(3), E2F3(3), ESPL1(9), FZR1(4), GADD45A(1), GADD45G(1), GSK3B(3), HDAC1(1), HDAC2(3), MAD1L1(4), MAD2L1(1), MAD2L2(1), MCM2(5), MCM3(4), MCM4(7), MCM5(2), MCM6(4), MCM7(8), MDM2(3), PCNA(1), PKMYT1(1), PLK1(3), PRKDC(28), RB1(17), RBL1(12), RBL2(6), RBX1(3), SFN(7), SKP1(1), SKP2(4), SMAD2(4), SMAD3(4), SMC1A(3), SMC1B(7), TFDP1(2), TGFB1(1), TGFB2(4), TGFB3(1), WEE1(2), YWHAB(2), YWHAE(2), YWHAG(1), YWHAH(2), YWHAQ(3), YWHAZ(2)	97955701	400	238	397	126	41	96	99	86	77	1	0.454	1.000	1.000
214	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	88	AKT1(2), AKT3(6), BCAR1(3), CAPN1(3), CAPN10(3), CAPN11(2), CAPN2(5), CAPN3(6), CAPN5(2), CAPN6(10), CAPN7(2), CAPN9(5), CAPNS1(2), CAV1(1), CDC42(3), CRK(2), CSK(1), DOCK1(15), FYN(4), GIT2(4), ILK(4), ITGA10(9), ITGA11(9), ITGA2(7), ITGA2B(6), ITGA3(5), ITGA4(14), ITGA5(4), ITGA6(4), ITGA7(8), ITGA9(3), ITGAD(8), ITGAE(4), ITGAL(8), ITGAM(8), ITGAV(6), ITGAX(8), ITGB1(15), ITGB2(3), ITGB3(6), ITGB4(8), ITGB5(1), ITGB6(5), ITGB7(1), ITGB8(5), MAP2K1(5), MAP2K2(6), MAP2K3(5), MAP2K6(1), MAPK10(4), MAPK12(3), MAPK4(7), MAPK6(4), MAPK7(6), MYLK2(5), PAK1(3), PAK2(8), PAK3(5), PAK4(1), PAK6(5), PDPK1(4), PIK3R2(5), PTK2(8), PXN(2), RAC2(3), RAC3(3), RAP1B(3), RAPGEF1(5), RHO(3), ROCK1(19), ROCK2(11), SDCCAG8(6), SEPP1(1), SHC1(2), SHC3(6), SORBS1(7), SOS1(9), SRC(1), TLN1(22), TNS1(9), VASP(1), VAV2(4), VAV3(4), VCL(5), ZYX(2)	100170207	453	237	448	155	74	96	135	74	74	0	0.271	1.000	1.000
215	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	89	AKT1(2), AKT2(4), AKT3(6), BCL10(1), CARD11(12), CBL(3), CBLB(7), CBLC(1), CD247(2), CD28(3), CD3D(1), CD4(1), CD40LG(4), CD8A(3), CD8B(2), CDC42(3), CDK4(5), CHUK(6), CTLA4(2), FOS(6), FYN(4), GRAP2(3), ICOS(1), IFNG(2), IKBKB(11), IL2(2), IL4(1), IL5(2), ITK(3), JUN(1), KRAS(1), LAT(3), LCK(5), LCP2(2), MALT1(3), MAP3K8(4), NCK1(5), NCK2(7), NFAT5(12), NFATC1(7), NFATC2(15), NFATC3(5), NFATC4(3), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(1), NFKBIE(1), NRAS(1), PAK1(3), PAK2(8), PAK3(5), PAK4(1), PAK6(5), PAK7(9), PDCD1(1), PDK1(3), PIK3CB(6), PIK3CD(8), PIK3CG(20), PIK3R1(9), PIK3R2(5), PIK3R3(4), PIK3R5(10), PLCG1(9), PPP3CA(2), PPP3CB(1), PRKCQ(8), PTPN6(3), PTPRC(18), RASGRP1(8), SOS1(9), SOS2(11), TEC(2), VAV1(7), VAV2(4), VAV3(4), ZAP70(4)	75173229	377	235	375	124	61	68	110	66	72	0	0.439	1.000	1.000
216	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	119	ARAF(3), BID(3), BRAF(10), CASP3(2), CD244(3), CD247(2), CD48(1), FAS(5), FASLG(1), FCGR3A(7), FYN(4), GZMB(2), HLA-C(5), HLA-E(1), HLA-G(2), ICAM1(6), ICAM2(3), IFNA10(1), IFNA14(1), IFNA16(4), IFNA17(3), IFNA2(1), IFNA21(2), IFNA4(3), IFNA6(1), IFNA8(3), IFNAR1(2), IFNAR2(2), IFNG(2), IFNGR1(4), IFNGR2(4), ITGAL(8), ITGB2(3), KIR2DL3(1), KIR3DL1(3), KLRC1(1), KLRC2(1), KLRC3(3), KLRK1(1), KRAS(1), LAT(3), LCK(5), LCP2(2), MAP2K1(5), MAP2K2(6), MICB(3), NCR1(6), NCR2(3), NFAT5(12), NFATC1(7), NFATC2(15), NFATC3(5), NFATC4(3), NRAS(1), PAK1(3), PIK3CB(6), PIK3CD(8), PIK3CG(20), PIK3R1(9), PIK3R2(5), PIK3R3(4), PIK3R5(10), PLCG1(9), PLCG2(9), PPP3CA(2), PPP3CB(1), PRF1(5), PRKCA(7), PRKCG(14), PTK2B(4), PTPN11(2), PTPN6(3), RAC2(3), RAC3(3), RAF1(3), SH2D1A(6), SH2D1B(2), SH3BP2(4), SHC1(2), SHC2(5), SHC3(6), SHC4(6), SOS1(9), SOS2(11), SYK(8), TNFRSF10A(3), TNFRSF10B(1), TNFRSF10D(1), TNFSF10(1), ULBP1(1), ULBP2(1), VAV1(7), VAV2(4), VAV3(4), ZAP70(4)	82183378	407	231	403	138	75	77	116	65	74	0	0.281	1.000	1.000
217	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	83	ACVR1(4), ACVR1B(5), ACVR1C(8), ACVR2A(1), ACVR2B(1), ACVRL1(3), AMHR2(1), BMP2(5), BMP4(4), BMP5(6), BMP6(8), BMP7(3), BMP8A(1), BMP8B(4), BMPR1B(4), BMPR2(6), CHRD(11), CREBBP(37), CUL1(11), DCN(4), E2F4(3), E2F5(6), GDF5(4), GDF6(6), ID1(1), ID2(1), ID3(1), IFNG(2), INHBA(3), INHBB(4), INHBC(3), INHBE(1), LEFTY1(2), LEFTY2(1), LTBP1(22), MYC(6), NODAL(1), NOG(2), PITX2(2), PPP2CB(3), PPP2R1A(3), PPP2R1B(4), PPP2R2A(2), PPP2R2B(5), PPP2R2C(1), RBL1(12), RBL2(6), RBX1(3), ROCK1(19), ROCK2(11), RPS6KB1(4), RPS6KB2(2), SKP1(1), SMAD1(3), SMAD2(4), SMAD3(4), SMAD5(1), SMAD6(1), SMAD9(4), SMURF1(4), SMURF2(6), SP1(3), TFDP1(2), TGFB1(1), TGFB2(4), TGFB3(1), TGFBR1(2), THBS1(8), THBS2(10), THBS3(3), THBS4(7), ZFYVE16(10), ZFYVE9(8)	69188331	360	215	357	91	36	80	107	71	65	1	0.00528	1.000	1.000
218	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	73	ABL1(8), ACTN1(4), ACTR2(1), AKT1(2), AKT2(4), AKT3(6), ANGPTL2(3), ARHGEF6(7), ARHGEF7(2), BCAR1(3), BRAF(10), CAV1(1), CDC42(3), CRK(2), CSE1L(3), DOCK1(15), EPHB2(3), FYN(4), GRB7(1), ILK(4), ITGA1(4), ITGA10(9), ITGA11(9), ITGA2(7), ITGA3(5), ITGA4(14), ITGA5(4), ITGA6(4), ITGA7(8), ITGA9(3), ITGB3BP(1), MAP2K4(2), MAP2K7(2), MAP3K11(2), MAPK10(4), MAPK8(4), MAPK8IP1(4), MAPK8IP2(2), MAPK8IP3(9), MAPK9(4), MYLK(8), MYLK2(5), P4HB(1), PAK1(3), PAK2(8), PAK3(5), PAK4(1), PAK6(5), PAK7(9), PIK3CB(6), PKLR(3), PLCG1(9), PLCG2(9), PTK2(8), RAF1(3), RHO(3), ROCK1(19), ROCK2(11), SHC1(2), SOS1(9), SOS2(11), SRC(1), TERF2IP(1), TLN1(22), TLN2(12), VASP(1), WAS(2), ZYX(2)	88373600	366	214	364	135	59	64	113	75	55	0	0.796	1.000	1.000
219	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	108	A4GNT(5), ALG1(4), ALG10(7), ALG10B(3), ALG11(3), ALG12(5), ALG13(4), ALG2(2), ALG3(1), ALG6(4), ALG8(1), B3GNT1(3), B3GNT2(1), B3GNT6(2), B3GNT7(3), B4GALT1(1), B4GALT2(5), B4GALT3(1), B4GALT4(2), B4GALT5(3), B4GALT7(2), C1GALT1(4), C1GALT1C1(2), CHPF(7), CHST1(4), CHST11(3), CHST12(6), CHST13(7), CHST14(2), CHST2(6), CHST4(4), CHST6(8), CHST7(1), CHSY1(3), DDOST(1), DPAGT1(1), EXT1(3), EXT2(5), EXTL1(3), EXTL2(3), EXTL3(2), FUT8(2), GALNT1(1), GALNT10(5), GALNT11(4), GALNT12(4), GALNT13(9), GALNT14(6), GALNT2(7), GALNT3(6), GALNT4(3), GALNT5(4), GALNT6(4), GALNT7(3), GALNT8(6), GALNT9(1), GALNTL5(5), GANAB(4), GCNT1(1), GCNT3(1), GCNT4(4), HS2ST1(5), HS3ST2(2), HS3ST3A1(3), HS3ST3B1(1), HS3ST5(6), HS6ST1(3), HS6ST2(1), HS6ST3(1), MAN1A1(2), MAN1A2(1), MAN1B1(4), MAN1C1(3), MAN2A1(5), MGAT1(4), MGAT2(3), MGAT3(4), MGAT4A(2), MGAT4B(3), MGAT5(4), MGAT5B(5), NDST1(1), NDST2(2), NDST3(7), NDST4(15), OGT(4), RPN1(2), RPN2(6), ST3GAL1(2), ST3GAL2(1), ST3GAL3(4), ST3GAL4(1), ST6GAL1(4), ST6GALNAC1(1), STT3B(2), UST(2), WBSCR17(10), XYLT1(10), XYLT2(3)	84248498	356	213	356	139	73	73	112	49	48	1	0.759	1.000	1.000
220	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	94	AKT1(2), AKT2(4), AKT3(6), CCL3(1), CCL4(1), CD14(1), CD40(7), CD80(4), CD86(2), CHUK(6), CXCL10(3), CXCL9(3), FADD(3), FOS(6), IFNA10(1), IFNA14(1), IFNA16(4), IFNA17(3), IFNA2(1), IFNA21(2), IFNA4(3), IFNA6(1), IFNA8(3), IFNAR1(2), IFNAR2(2), IKBKB(11), IKBKE(5), IL12A(1), IL12B(3), IL1B(1), IL6(2), IRAK1(3), IRAK4(3), IRF3(1), IRF5(3), IRF7(3), JUN(1), LBP(7), LY96(2), MAP2K1(5), MAP2K2(6), MAP2K3(5), MAP2K4(2), MAP2K6(1), MAP2K7(2), MAP3K7(8), MAP3K8(4), MAPK10(4), MAPK11(3), MAPK12(3), MAPK13(3), MAPK14(2), MAPK8(4), MAPK9(4), NFKB1(5), NFKB2(5), NFKBIA(1), PIK3CB(6), PIK3CD(8), PIK3CG(20), PIK3R1(9), PIK3R2(5), PIK3R3(4), PIK3R5(10), RELA(2), RIPK1(2), SPP1(2), STAT1(8), TBK1(3), TICAM1(5), TIRAP(1), TLR1(3), TLR2(2), TLR3(1), TLR4(17), TLR5(3), TLR6(3), TLR7(8), TLR8(7), TLR9(4), TOLLIP(2), TRAF3(6), TRAF6(3)	65080330	329	213	326	117	54	70	101	50	54	0	0.406	1.000	1.000
221	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	66	A2M(7), BDKRB1(2), BDKRB2(3), C1QA(2), C1QC(1), C1R(3), C1S(6), C2(5), C3(15), C3AR1(5), C4BPA(6), C4BPB(2), C5(10), C5AR1(2), C7(12), C8A(8), C8B(9), C8G(1), C9(15), CD46(2), CD59(1), CFB(4), CFH(18), CFI(4), CPB2(4), CR1(10), CR2(7), F10(3), F11(2), F12(2), F13A1(9), F13B(13), F2(3), F2R(4), F3(2), F5(19), F7(2), F8(7), F9(8), FGA(12), FGB(4), FGG(6), KLKB1(9), KNG1(4), MASP1(7), MASP2(5), MBL2(2), PLAT(4), PLG(13), PROC(2), PROS1(10), SERPINA1(5), SERPINA5(9), SERPINC1(4), SERPIND1(4), SERPINE1(7), SERPING1(5), TFPI(2), THBD(2), VWF(19)	67536252	373	210	371	131	46	96	106	69	55	1	0.560	1.000	1.000
222	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	78	ABL1(8), ATM(16), BUB1(6), BUB1B(6), CCNA1(7), CCNA2(4), CCNB1(2), CCNB3(11), CCND2(2), CCNE1(4), CCNE2(4), CDAN1(5), CDC14A(3), CDC14B(1), CDC20(1), CDC25A(3), CDC25B(4), CDC25C(4), CDC6(2), CDC7(1), CDH1(5), CDK4(5), CHEK1(1), CHEK2(4), DTX4(5), E2F2(3), E2F3(3), E2F4(3), E2F5(6), E2F6(1), ESPL1(9), GADD45A(1), GSK3B(3), HDAC1(1), HDAC2(3), HDAC3(4), HDAC4(11), HDAC5(3), HDAC6(7), HDAC8(1), MAD1L1(4), MAD2L1(1), MAD2L2(1), MCM2(5), MCM3(4), MCM4(7), MCM5(2), MCM6(4), MCM7(8), MDM2(3), MPEG1(7), MPL(4), PCNA(1), PLK1(3), PRKDC(28), PTPRA(2), RB1(17), RBL1(12), SKP2(4), TBC1D8(4), TFDP1(2), TGFB1(1), WEE1(2)	78072177	299	202	298	100	35	69	73	58	64	0	0.618	1.000	1.000
223	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	90	ACTB(4), BAD(1), BCL2(1), CABIN1(14), CALM1(1), CALM2(2), CALM3(2), CAMK2B(3), CD69(1), CEBPB(1), CNR1(3), CREBBP(37), CSNK2A1(7), CSNK2B(2), CTLA4(2), EGR2(5), FCER1A(4), FCGR3A(7), FKBP1B(1), FOS(6), FOSL1(3), GATA3(8), GSK3A(2), GSK3B(3), ICOS(1), IFNG(2), IL13(1), IL1B(1), IL2(2), IL2RA(2), IL3(1), IL4(1), IL6(2), ITK(3), JUNB(2), KPNA5(2), MAP2K7(2), MAPK14(2), MAPK8(4), MAPK9(4), MEF2A(3), MEF2B(5), MEF2D(1), MYF5(6), NCK2(7), NFAT5(12), NFATC1(7), NFATC2(15), NFATC3(5), NFATC4(3), NFKB2(5), NFKBIB(1), NFKBIE(1), NPPB(2), NUP214(12), OPRD1(2), P2RX7(1), PAK1(3), PIN1(1), PPP3CB(1), PTPRC(18), RELA(2), RPL13A(2), SFN(7), SLA(1), SP1(3), SP3(3), TGFB1(1), TRAF2(2), TRPV6(7), VAV1(7), VAV2(4), VAV3(4), XPO5(4)	65424515	310	201	309	110	40	60	94	63	52	1	0.549	1.000	1.000
224	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	81	ATF2(1), BRAF(10), CHUK(6), CREB1(1), DAXX(6), ELK1(2), FOS(6), IKBKB(11), JUN(1), MAP2K1(5), MAP2K2(6), MAP2K3(5), MAP2K4(2), MAP2K5(3), MAP2K6(1), MAP2K7(2), MAP3K1(6), MAP3K10(5), MAP3K11(2), MAP3K12(8), MAP3K13(15), MAP3K2(2), MAP3K3(2), MAP3K4(14), MAP3K5(6), MAP3K6(7), MAP3K7(8), MAP3K8(4), MAP3K9(9), MAP4K1(5), MAP4K2(2), MAP4K3(6), MAP4K4(4), MAP4K5(1), MAPK10(4), MAPK11(3), MAPK12(3), MAPK13(3), MAPK14(2), MAPK4(7), MAPK6(4), MAPK7(6), MAPK8(4), MAPK9(4), MAPKAPK3(3), MAPKAPK5(2), MAX(1), MEF2A(3), MEF2B(5), MEF2D(1), MKNK1(1), MKNK2(2), MYC(6), NFKB1(5), NFKBIA(1), PAK1(3), PAK2(8), RAF1(3), RELA(2), RIPK1(2), RPS6KA1(10), RPS6KA2(6), RPS6KA3(4), RPS6KA4(3), RPS6KA5(5), RPS6KB1(4), RPS6KB2(2), SHC1(2), SP1(3), STAT1(8), TGFB1(1), TGFB2(4), TGFB3(1), TGFBR1(2), TRADD(1), TRAF2(2)	70956762	320	196	315	105	54	66	102	50	48	0	0.395	1.000	1.000
225	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	70	ACACB(18), ACSL1(3), ACSL3(3), ACSL4(6), ACSL5(5), ACSL6(2), ADIPOQ(3), ADIPOR1(3), ADIPOR2(3), AGRP(1), AKT1(2), AKT2(4), AKT3(6), CAMKK1(1), CAMKK2(6), CD36(1), CHUK(6), CPT1A(6), CPT1B(4), CPT1C(8), CPT2(7), G6PC(2), G6PC2(6), IKBKB(11), IRS1(2), IRS2(6), IRS4(16), JAK1(10), JAK2(5), JAK3(6), LEP(1), LEPR(17), MAPK10(4), MAPK8(4), MAPK9(4), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(1), NFKBIE(1), NPY(5), PCK1(2), PCK2(4), POMC(1), PPARA(2), PPARGC1A(6), PRKAA1(4), PRKAA2(5), PRKAB1(4), PRKAB2(1), PRKAG2(2), PRKAG3(3), PRKCQ(8), PTPN11(2), RELA(2), RXRA(4), RXRB(3), RXRG(7), SLC2A1(4), SLC2A4(3), SOCS3(1), STAT3(6), STK11(6), TNFRSF1A(2), TNFRSF1B(2), TRADD(1), TRAF2(2), TYK2(8)	63324449	305	191	305	97	52	60	86	52	54	1	0.117	1.000	1.000
226	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	59	AKT1(2), AKT2(4), AKT3(6), BCL10(1), BLNK(4), BTK(8), CARD11(12), CD19(4), CD22(3), CD72(1), CD79A(1), CHUK(6), CR2(7), FCGR2B(1), FOS(6), GSK3B(3), IKBKB(11), INPP5D(8), JUN(1), KRAS(1), LILRB3(4), LYN(8), MALT1(3), NFAT5(12), NFATC1(7), NFATC2(15), NFATC3(5), NFATC4(3), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(1), NFKBIE(1), NRAS(1), PIK3CB(6), PIK3CD(8), PIK3CG(20), PIK3R1(9), PIK3R2(5), PIK3R3(4), PIK3R5(10), PLCG2(9), PPP3CA(2), PPP3CB(1), PTPN6(3), RAC2(3), RAC3(3), RASGRP3(9), SYK(8), VAV1(7), VAV2(4), VAV3(4)	54526337	276	190	274	95	52	55	74	47	47	1	0.370	1.000	1.000
227	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	60	AKT1(2), AKT2(4), AKT3(6), BAD(1), BCL2L1(2), CDC42(3), CDKN1B(2), CREB1(1), CREB5(7), EBP(1), ERBB4(22), F2RL2(2), GAB1(5), GADD45A(1), GSK3A(2), GSK3B(3), IGF1(1), IGFBP1(3), INPPL1(8), IRS1(2), IRS2(6), IRS4(16), MET(4), MYC(6), NOLC1(6), PAK1(3), PAK2(8), PAK3(5), PAK4(1), PAK6(5), PAK7(9), PARD3(14), PARD6A(1), PDK1(3), PIK3CD(8), PPP1R13B(2), PREX1(14), PTK2(8), PTPN1(3), RPS6KA1(10), RPS6KA2(6), RPS6KA3(4), RPS6KB1(4), SFN(7), SHC1(2), SLC2A4(3), SOS1(9), SOS2(11), TSC1(3), TSC2(7), YWHAB(2), YWHAE(2), YWHAG(1), YWHAH(2), YWHAQ(3), YWHAZ(2)	56229248	278	187	276	86	40	61	79	50	48	0	0.159	1.000	1.000
228	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	77	AIFM1(1), AKT1(2), AKT2(4), AKT3(6), APAF1(12), ATM(16), BAD(1), BCL2(1), BCL2L1(2), BID(3), BIRC2(3), BIRC3(2), CAPN1(3), CAPN2(5), CASP10(2), CASP3(2), CASP6(5), CASP7(3), CASP9(1), CFLAR(2), CHUK(6), CSF2RB(7), FADD(3), FAS(5), FASLG(1), IKBKB(11), IL1A(1), IL1B(1), IL1R1(4), IL1RAP(6), IL3(1), IL3RA(5), IRAK1(3), IRAK2(2), IRAK3(9), IRAK4(3), NFKB1(5), NFKB2(5), NFKBIA(1), NTRK1(3), PIK3CB(6), PIK3CD(8), PIK3CG(20), PIK3R1(9), PIK3R2(5), PIK3R3(4), PIK3R5(10), PPP3CA(2), PPP3CB(1), PRKACA(4), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), RELA(2), RIPK1(2), TNFRSF10A(3), TNFRSF10B(1), TNFRSF10D(1), TNFRSF1A(2), TNFSF10(1), TRADD(1), TRAF2(2)	60550736	258	186	255	79	42	59	59	46	52	0	0.152	1.000	1.000
229	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	70	AKT1(2), AKT2(4), AKT3(6), BTK(8), FCER1A(4), FYN(4), GAB2(4), IL13(1), IL3(1), IL4(1), IL5(2), INPP5D(8), KRAS(1), LAT(3), LCP2(2), LYN(8), MAP2K1(5), MAP2K2(6), MAP2K3(5), MAP2K4(2), MAP2K6(1), MAP2K7(2), MAPK10(4), MAPK11(3), MAPK12(3), MAPK13(3), MAPK14(2), MAPK8(4), MAPK9(4), MS4A2(4), NRAS(1), PDK1(3), PIK3CB(6), PIK3CD(8), PIK3CG(20), PIK3R1(9), PIK3R2(5), PIK3R3(4), PIK3R5(10), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PLCG1(9), PLCG2(9), PRKCA(7), PRKCD(4), PRKCE(3), RAC2(3), RAC3(3), RAF1(3), SOS1(9), SOS2(11), SYK(8), VAV1(7), VAV2(4), VAV3(4)	52132051	274	184	272	97	48	45	85	46	49	1	0.657	1.000	1.000
230	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	45	FN3K(3), IMPA1(2), IMPA2(2), INPP1(2), INPP4A(8), INPP4B(11), INPP5A(3), INPP5B(5), INPP5E(1), INPPL1(8), IPMK(2), ISYNA1(4), ITPK1(3), ITPKB(5), MINPP1(5), MIOX(4), OCRL(3), PI4KA(7), PI4KB(2), PIK3C3(5), PIK3CB(6), PIK3CD(8), PIK3CG(20), PIP4K2B(3), PIP4K2C(3), PIP5K1A(3), PIP5K1B(9), PIP5K1C(2), PLCB1(22), PLCB2(6), PLCB3(9), PLCB4(16), PLCD1(5), PLCD3(2), PLCD4(3), PLCE1(22), PLCG1(9), PLCG2(9), PLCZ1(7), PTPMT1(2), SYNJ1(10), SYNJ2(8)	54361599	269	183	264	93	54	49	82	47	37	0	0.265	1.000	1.000
231	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	54	ASH1L(20), ASH2L(3), CARM1(5), CTCFL(4), DOT1L(9), EED(3), EHMT1(7), EHMT2(10), EZH1(5), EZH2(5), FBXO11(6), HCFC1(8), HSF4(1), JMJD4(1), JMJD6(2), KDM6A(17), MEN1(3), OGT(4), PAXIP1(4), PPP1CA(1), PRDM2(14), PRDM7(3), PRDM9(35), PRMT1(2), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(6), RBBP5(2), SATB1(6), SETD1A(10), SETD2(12), SETD7(4), SETD8(1), SETDB1(9), SETDB2(2), SETMAR(2), SMYD3(3), STK38(2), SUV39H1(4), SUV39H2(2), SUV420H1(6), SUV420H2(4), SUZ12(2), WHSC1(9), WHSC1L1(6)	86383086	272	178	268	84	42	50	78	49	53	0	0.353	1.000	1.000
232	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	26	BRAF(10), CPEB1(5), EGFR(19), ERBB2(12), ERBB4(22), ETS1(5), ETS2(7), ETV6(6), ETV7(4), FMN2(40), KRAS(1), MAP2K1(5), NOTCH2(22), NOTCH3(22), NOTCH4(8), PIWIL1(9), PIWIL2(10), PIWIL3(8), PIWIL4(3), RAF1(3), SOS1(9), SOS2(11), SPIRE1(5), SPIRE2(1)	36261336	247	177	244	74	35	49	78	41	44	0	0.487	1.000	1.000
233	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CD2BP2(6), CDC40(3), CLK2(11), CLK3(4), CLK4(2), COL2A1(6), CPSF1(7), CPSF2(5), CPSF3(2), CSTF1(1), CSTF2(2), CSTF2T(2), CSTF3(2), DDX1(5), DDX20(4), DHX15(4), DHX16(9), DHX38(3), DHX8(5), DHX9(7), DICER1(15), DNAJC8(3), FUS(4), GIPC1(3), LSM2(1), METTL3(5), NCBP1(6), NCBP2(3), NONO(5), NUDT21(2), NXF1(4), PABPN1(4), PAPOLA(3), PHF5A(2), POLR2A(12), PRPF18(1), PRPF3(7), PRPF4(2), PRPF4B(7), PRPF8(12), PTBP1(3), PTBP2(4), RBM17(1), RBM5(8), RNGTT(1), RNMT(5), RNPS1(3), SF3A1(2), SF3A2(3), SF3A3(2), SF3B1(5), SF3B2(3), SF3B5(1), SNRPA(3), SNRPA1(1), SNRPB(1), SNRPB2(1), SNRPD2(2), SNRPE(1), SNRPN(8), SNURF(1), SPOP(6), SRPK1(1), SRPK2(10), SRRM1(4), SUPT5H(4), U2AF1(2), U2AF2(2), XRN2(8)	80690535	287	177	285	100	34	70	83	46	54	0	0.794	1.000	1.000
234	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	65	AGTR2(2), ATP8A1(17), AVPR1A(9), AVPR1B(6), AVPR2(2), BDKRB1(2), BDKRB2(3), BRS3(4), C3AR1(5), CCKAR(5), CCKBR(3), CCR1(1), CCR10(2), CCR2(4), CCR3(5), CCR4(4), CCR6(2), CCR7(2), CX3CR1(1), CXCR3(1), CXCR4(2), EDNRA(2), EDNRB(7), FPR1(6), FSHR(12), GALR1(3), GALR2(4), GALR3(2), GALT(2), GHSR(3), GNB2L1(1), GNRHR(2), GRPR(1), LHCGR(9), MC1R(3), MC2R(6), MC3R(2), MC4R(4), MC5R(9), NMBR(3), NPY1R(5), NPY2R(5), NPY5R(8), NTSR1(3), NTSR2(6), OPRD1(2), OPRK1(6), OPRL1(6), OPRM1(5), OXTR(3), SSTR1(8), SSTR2(3), SSTR3(6), SSTR4(6), TACR1(4), TACR2(4), TACR3(5), TRHR(5), TSHR(4)	39384568	257	175	257	98	45	60	81	37	34	0	0.138	1.000	1.000
235	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	65	AKT1(2), AKT2(4), AKT3(6), BAD(1), CASP9(1), CDC42(3), KDR(14), KRAS(1), MAP2K1(5), MAP2K2(6), MAPK11(3), MAPK12(3), MAPK13(3), MAPK14(2), MAPKAPK3(3), NFAT5(12), NFATC1(7), NFATC2(15), NFATC3(5), NFATC4(3), NOS3(4), NRAS(1), PIK3CB(6), PIK3CD(8), PIK3CG(20), PIK3R1(9), PIK3R2(5), PIK3R3(4), PIK3R5(10), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PLCG1(9), PLCG2(9), PPP3CA(2), PPP3CB(1), PRKCA(7), PRKCG(14), PTGS2(3), PTK2(8), PXN(2), RAC2(3), RAC3(3), RAF1(3), SHC2(5), SPHK2(3), SRC(1)	52166642	256	172	254	98	53	50	71	41	41	0	0.631	1.000	1.000
236	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	52	ADORA3(3), ALG6(4), CCKBR(3), CCR2(4), CCR3(5), CELSR1(24), CELSR2(27), CELSR3(17), CHRM2(5), CHRM3(9), CXCR3(1), DRD4(1), EDNRA(2), EMR2(2), EMR3(3), F2R(4), FSHR(12), GHRHR(3), GNRHR(2), GPR116(8), GPR132(4), GPR133(9), GPR135(1), GPR143(1), GPR17(3), GPR18(1), GPR55(1), GPR56(3), GPR61(3), GPR84(3), GRM1(28), GRPR(1), HRH4(3), LGR6(10), LPHN2(10), LPHN3(22), LTB4R2(2), NTSR1(3), OR2M4(7), P2RY13(2), PTGFR(2), SMO(3), SSTR2(3), TAAR5(1), TSHR(4), VN1R1(2)	50757056	271	167	270	103	51	60	80	43	37	0	0.305	1.000	1.000
237	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	42	ACTR2(1), AKT1(2), AKT2(4), AKT3(6), ANGPTL2(3), ARHGAP1(4), ARHGAP4(10), ARHGEF11(3), BTK(8), CDC42(3), CFL1(2), GDI1(5), GDI2(5), INPPL1(8), ITPR1(15), ITPR2(25), ITPR3(10), LIMK1(5), MYLK(8), MYLK2(5), PAK1(3), PAK2(8), PAK3(5), PAK4(1), PAK6(5), PAK7(9), PDK1(3), PIK3CD(8), PIK3CG(20), PIK3R1(9), PITX2(2), PPP1R13B(2), RACGAP1(5), RHO(3), ROCK1(19), ROCK2(11), SAG(1), WASF1(3), WASL(2)	51049210	251	167	249	100	42	63	64	44	37	1	0.763	1.000	1.000
238	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(5), AMY2A(3), AMY2B(8), ENPP1(10), ENPP3(8), G6PC(2), GAA(3), GANAB(4), GCK(4), GPI(3), GUSB(5), GYS1(6), GYS2(6), HK1(4), HK2(6), HK3(8), MGAM(29), PGM1(5), PGM3(1), PYGB(6), PYGL(9), PYGM(8), SI(59), UCHL3(1), UGDH(3), UGT1A1(5), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A9(1), UGT2B15(4), UGT2B4(13), UXS1(2)	43293602	244	166	241	82	30	46	77	49	41	1	0.579	1.000	1.000
239	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	64	ADAM10(6), ADAM17(5), ATP6AP1(2), ATP6V0A1(4), ATP6V0A2(3), ATP6V0A4(6), ATP6V0B(1), ATP6V0C(1), ATP6V0D1(2), ATP6V0D2(3), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(4), ATP6V1C1(4), ATP6V1C2(3), ATP6V1D(2), ATP6V1E1(2), ATP6V1E2(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(3), ATP6V1H(3), CASP3(2), CDC42(3), CHUK(6), CSK(1), CXCL1(3), EGFR(19), F11R(1), GIT1(5), IGSF5(4), IKBKB(11), JAM2(2), JUN(1), LYN(8), MAP2K4(2), MAPK10(4), MAPK11(3), MAPK12(3), MAPK13(3), MAPK14(2), MAPK8(4), MAPK9(4), MET(4), NFKB1(5), NFKB2(5), NFKBIA(1), NOD1(7), PAK1(3), PLCG1(9), PLCG2(9), PTPN11(2), PTPRZ1(16), RELA(2), SRC(1), TCIRG1(7), TJP1(13)	53224303	237	165	236	76	27	51	74	47	38	0	0.410	1.000	1.000
240	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	62	ATM(16), CCNA1(7), CCNB1(2), CCND1(3), CCND2(2), CCNE1(4), CCNE2(4), CCNG2(4), CDC25A(3), CDK4(5), CDKN1B(2), CDKN2C(1), CDKN2D(1), CREB3L1(4), CREB3L3(9), CREB3L4(2), E2F2(3), E2F3(3), E2F4(3), E2F5(6), E2F6(1), GADD45A(1), GBA2(6), MCM2(5), MCM3(4), MCM4(7), MCM5(2), MCM6(4), MCM7(8), MDM2(3), MNAT1(1), MYC(6), MYT1(11), NACA(24), PCNA(1), POLA2(2), POLE(11), PRIM1(3), RB1(17), RBL1(12), RPA1(5), RPA2(1), TFDP1(2), TFDP2(1), TNXB(25), WEE1(2)	57838056	249	164	246	71	30	62	70	39	47	1	0.121	1.000	1.000
241	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	82	CD14(1), CD19(4), CD1A(8), CD1B(2), CD1C(5), CD1D(5), CD2(1), CD22(3), CD33(2), CD34(5), CD36(1), CD38(5), CD3D(1), CD4(1), CD44(3), CD5(1), CD59(1), CD8A(3), CD8B(2), CD9(1), CR1(10), CR2(7), CSF1(2), CSF1R(2), CSF2RA(1), CSF3R(3), DNTT(2), EPO(2), EPOR(1), FCER2(1), FCGR1A(1), FLT3(6), FLT3LG(1), GP5(4), GP9(2), HLA-DRA(1), HLA-DRB1(2), IL11RA(2), IL1A(1), IL1B(1), IL1R1(4), IL1R2(1), IL2RA(2), IL3(1), IL3RA(5), IL4(1), IL4R(8), IL5(2), IL5RA(3), IL6(2), IL6R(6), IL7(2), IL7R(6), IL9R(6), ITGA1(4), ITGA2(7), ITGA2B(6), ITGA3(5), ITGA4(14), ITGA5(4), ITGA6(4), ITGAM(8), ITGB3(6), KIT(12), KITLG(1), MME(16), MS4A1(4), TFRC(8), THPO(1), TPO(12)	61562363	268	163	265	110	41	54	75	55	43	0	0.932	1.000	1.000
242	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	44	AKT1(2), AKT2(4), AKT3(6), BAD(1), BCL2(1), BCR(2), BLNK(4), BTK(8), CD19(4), CD22(3), CR2(7), CSK(1), DAG1(5), FLOT1(2), FLOT2(3), GSK3A(2), GSK3B(3), INPP5D(8), ITPR1(15), ITPR2(25), ITPR3(10), LYN(8), MAP4K1(5), NFATC1(7), NFATC2(15), NR0B2(1), PDK1(3), PIK3CD(8), PIK3R1(9), PLCG2(9), PPP1R13B(2), PPP3CA(2), PPP3CB(1), PTPRC(18), RAF1(3), SHC1(2), SOS1(9), SOS2(11), SYK(8), VAV1(7)	54159644	244	160	243	92	40	55	55	53	40	1	0.624	1.000	1.000
243	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	56	BMP2(5), BMP4(4), BMP5(6), BMP6(8), BMP7(3), BMP8A(1), BMP8B(4), BTRC(1), CSNK1A1(1), CSNK1A1L(4), CSNK1D(1), CSNK1E(6), CSNK1G1(1), CSNK1G2(1), CSNK1G3(1), DHH(1), FBXW11(3), GLI1(7), GLI2(16), GLI3(12), GSK3B(3), HHIP(5), IHH(2), LRP2(40), PRKACA(4), PRKACB(3), PRKACG(2), PRKX(1), PTCH1(13), PTCH2(10), RAB23(2), SHH(2), SMO(3), STK36(6), SUFU(3), WNT1(2), WNT10A(2), WNT11(2), WNT16(3), WNT2(3), WNT2B(1), WNT3(4), WNT3A(1), WNT4(2), WNT5A(3), WNT5B(1), WNT6(2), WNT7A(3), WNT7B(1), WNT8A(2), WNT8B(4), WNT9A(6), WNT9B(3), ZIC2(6)	46433064	236	158	235	82	51	43	85	33	24	0	0.364	1.000	1.000
244	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	33	AKT1(2), AKT2(4), AKT3(6), ASAH1(1), BRAF(10), DAG1(5), DRD2(4), EGFR(19), EPHB2(3), ITPKB(5), ITPR1(15), ITPR2(25), ITPR3(10), KCNJ3(9), KCNJ5(3), KCNJ9(1), PI3(2), PIK3CB(6), PITX2(2), PLCB1(22), PLCB2(6), PLCB3(9), PLCB4(16), RAF1(3), RGS20(4), SHC1(2), SOS1(9), SOS2(11), SRC(1), STAT3(6), TERF2IP(1)	43964357	222	158	221	75	34	47	64	51	26	0	0.357	1.000	1.000
245	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACADL(4), ACADM(3), ACOX1(2), ACOX2(2), ACOX3(1), ACSL1(3), ACSL3(3), ACSL4(6), ACSL5(5), ACSL6(2), ADIPOQ(3), ANGPTL4(3), APOA5(2), AQP7(3), CD36(1), CPT1A(6), CPT1B(4), CPT1C(8), CPT2(7), CYP27A1(2), CYP4A11(12), CYP4A22(9), CYP7A1(6), CYP8B1(6), DBI(4), EHHADH(5), FABP1(3), FABP2(2), FABP3(1), FABP4(3), FABP5(1), FABP6(3), FABP7(1), FADS2(4), GK(5), GK2(7), HMGCS2(2), ILK(4), LPL(4), ME1(2), MMP1(6), NR1H3(1), OLR1(1), PCK1(2), PCK2(4), PDPK1(4), PLTP(2), PPARA(2), PPARD(3), PPARG(1), RXRA(4), RXRB(3), RXRG(7), SCD(1), SCP2(3), SLC27A1(3), SLC27A2(2), SLC27A4(3), SLC27A5(4), SLC27A6(6), SORBS1(7), UBC(5), UCP1(1)	49890908	229	157	228	82	37	56	63	32	40	1	0.393	1.000	1.000
246	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	41	ADAM17(5), APH1A(4), CREBBP(37), CTBP1(2), CTBP2(2), DLL1(5), DLL3(2), DLL4(2), DTX1(4), DTX2(1), DTX3(5), DTX3L(2), DTX4(5), DVL1(8), DVL2(1), DVL3(9), HDAC1(1), HDAC2(3), JAG1(9), JAG2(7), LFNG(2), MAML1(6), MAML2(6), MAML3(2), MFNG(2), NCOR2(22), NCSTN(2), NOTCH2(22), NOTCH3(22), NOTCH4(8), NUMB(3), NUMBL(3), PSEN2(1), PTCRA(3), RBPJ(5), RBPJL(5), RFNG(3), SNW1(4)	46109642	235	156	234	96	46	53	59	28	48	1	0.823	1.000	1.000
247	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	AICDA(2), CAD(5), CANT1(3), CTPS2(1), DCK(4), DHODH(6), DPYD(16), DPYS(7), ENTPD1(4), ENTPD3(2), ENTPD4(5), ENTPD5(3), ENTPD6(2), ENTPD8(2), ITPA(4), NME2(1), NME4(2), NME7(4), NT5C1A(2), NT5C1B(7), NT5C2(2), NT5E(1), NUDT2(1), PNPT1(6), POLA1(4), POLA2(2), POLD1(11), POLD2(1), POLD3(4), POLE(11), POLR1A(9), POLR1B(3), POLR1C(2), POLR2A(12), POLR2B(9), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(3), POLR2G(4), POLR2H(1), POLR2I(1), POLR2J(2), POLR2L(3), POLR3A(8), POLR3B(4), POLR3G(1), POLR3GL(2), POLR3H(1), PRIM1(3), PRIM2(1), RFC5(2), RRM1(2), RRM2(1), RRM2B(1), TXNRD1(6), TXNRD2(2), TYMS(1), UCK1(3), UCK2(4), UMPS(1), UPB1(1), UPP1(3), UPP2(3), UPRT(2)	61670726	229	155	229	94	40	37	65	50	37	0	0.959	1.000	1.000
248	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	56	APC(27), AXIN1(12), CCND1(3), CCND2(2), CSNK1E(6), CTNNB1(6), DVL1(8), DVL2(1), DVL3(9), FBXW2(2), FOSL1(3), FZD1(6), FZD10(5), FZD2(4), FZD3(2), FZD5(1), FZD6(6), FZD7(2), FZD8(2), FZD9(2), GSK3B(3), JUN(1), LDLR(4), MAPK10(4), MAPK9(4), MYC(6), PAFAH1B1(2), PPP2R5C(3), PPP2R5E(3), PRKCA(7), PRKCD(4), PRKCE(3), PRKCG(14), PRKCH(4), PRKCI(3), PRKCQ(8), PRKCZ(3), PRKD1(15), SFRP4(11), TCF7(2), WNT1(2), WNT10A(2), WNT11(2), WNT16(3), WNT2(3), WNT2B(1), WNT3(4), WNT4(2), WNT5A(3), WNT5B(1), WNT6(2), WNT7A(3), WNT7B(1)	45251322	242	152	238	87	40	51	78	48	24	1	0.402	1.000	1.000
249	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	61	APAF1(12), ATM(16), ATR(24), BAI1(8), BID(3), CASP3(2), CASP9(1), CCNB1(2), CCNB3(11), CCND1(3), CCND2(2), CCNE1(4), CCNE2(4), CCNG1(1), CCNG2(4), CDK4(5), CDK6(1), CHEK1(1), CHEK2(4), DDB2(4), EI24(2), FAS(5), GADD45A(1), GADD45G(1), GTSE1(9), IGF1(1), IGFBP3(1), MDM2(3), MDM4(1), PERP(1), PMAIP1(2), PPM1D(7), RCHY1(1), RFWD2(2), RRM2(1), RRM2B(1), SERPINB5(1), SERPINE1(7), SESN1(2), SESN2(4), SESN3(4), SFN(7), SIAH1(4), STEAP3(4), THBS1(8), TNFRSF10B(1), TSC2(7), ZMAT3(2)	47338806	202	151	202	58	20	49	44	48	41	0	0.207	1.000	1.000
250	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(4), AKT1(2), BDKRB2(3), CALM1(1), CALM2(2), CALM3(2), CAV1(1), FLT1(17), FLT4(14), KDR(14), NOS3(4), PDE2A(5), PDE3A(19), PDE3B(4), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), PRKG1(7), PRKG2(2), RYR2(76), SLC7A1(4), SYT1(9)	30803422	206	151	206	74	32	54	57	36	26	1	0.499	1.000	1.000
251	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	47	ACOX1(2), CD36(1), CPT1B(4), CREBBP(37), DUSP1(2), EHHADH(5), FABP1(3), HSD17B4(5), JUN(1), LPL(4), ME1(2), MYC(6), NCOA1(7), NCOR1(20), NCOR2(22), NFKBIA(1), NR0B2(1), NR1H3(1), NR2F1(3), NRIP1(8), PIK3R1(9), PPARA(2), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), PRKCA(7), PTGS2(3), RB1(17), RELA(2), RXRA(4), SP1(3), STAT5A(3), STAT5B(5)	42311719	206	149	199	66	21	51	55	27	51	1	0.286	1.000	1.000
252	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	50	ACTG1(3), APAF1(12), ARHGDIB(1), BAG4(7), BCL2(1), BID(3), BIRC2(3), BIRC3(2), CASP2(3), CASP3(2), CASP6(5), CASP7(3), CASP9(1), CFLAR(2), CHUK(6), CRADD(2), DAXX(6), FADD(3), GSN(5), LMNA(1), LMNB1(2), LMNB2(8), MAP2K7(2), MAP3K1(6), MAP3K5(6), MAPK8(4), MDM2(3), NFKB1(5), NFKBIA(1), NUMA1(19), PAK2(8), PRKCD(4), PRKDC(28), PSEN2(1), PTK2(8), RB1(17), RELA(2), RIPK1(2), SPTAN1(23), TNFRSF1A(2), TNFRSF1B(2), TRADD(1), TRAF2(2)	50437276	227	148	227	73	29	51	62	37	48	0	0.406	1.000	1.000
253	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AADAT(3), AANAT(1), ACAT2(2), ACMSD(6), AFMID(5), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), ALDH9A1(3), AOC2(6), AOC3(5), AOX1(11), ASMT(4), CARM1(5), CAT(4), CYP1A1(2), CYP1A2(5), CYP1B1(5), DDC(7), ECHS1(2), EHHADH(5), GCDH(2), HAAO(1), HADH(4), HADHA(3), HEMK1(1), HSD17B10(1), HSD17B4(5), KMO(1), KYNU(9), LCMT1(2), LCMT2(6), MAOA(1), MAOB(1), METTL2B(3), METTL6(2), NFX1(2), OGDH(10), OGDHL(11), PRMT2(2), PRMT3(6), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(6), TDO2(4), TPH1(3), TPH2(6), WARS(2), WARS2(8)	46073837	203	148	203	64	30	44	62	33	34	0	0.278	1.000	1.000
254	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ADCY4(8), ADCY6(6), ADCY8(28), CACNA1A(14), CACNA1B(13), GNAS(13), GNAT3(6), GNB1(3), GNB3(6), GNG13(2), GRM4(2), ITPR3(10), KCNB1(3), PDE1A(6), PLCB2(6), PRKACA(4), PRKACB(3), PRKACG(2), PRKX(1), SCNN1A(3), SCNN1B(5), SCNN1G(5), TAS1R1(8), TAS1R2(5), TAS1R3(3), TAS2R1(4), TAS2R10(2), TAS2R13(1), TAS2R14(4), TAS2R16(4), TAS2R3(1), TAS2R38(3), TAS2R39(1), TAS2R40(5), TAS2R41(3), TAS2R42(1), TAS2R43(1), TAS2R46(6), TAS2R50(1), TAS2R60(3), TAS2R7(2), TAS2R8(7), TAS2R9(2), TRPM5(5)	43464946	221	148	219	111	51	40	52	44	34	0	0.976	1.000	1.000
255	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	45	AKT1(2), AKT2(4), AKT3(6), BRD4(10), CAP1(3), CBL(3), CDC42(3), F2RL2(2), FLOT1(2), FLOT2(3), GSK3A(2), GSK3B(3), IGFBP1(3), INPPL1(8), IRS1(2), IRS2(6), IRS4(16), LNPEP(5), PARD3(14), PARD6A(1), PDK1(3), PIK3CD(8), PIK3R1(9), PTPN1(3), RAF1(3), RPS6KA1(10), RPS6KA2(6), RPS6KA3(4), RPS6KB1(4), SERPINB6(4), SFN(7), SHC1(2), SLC2A4(3), SORBS1(7), SOS1(9), SOS2(11), YWHAB(2), YWHAE(2), YWHAG(1), YWHAH(2), YWHAQ(3), YWHAZ(2)	42171541	203	144	202	58	35	45	55	34	34	0	0.139	1.000	1.000
256	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(2), ADH1B(2), ADH4(2), ADH5(3), ADH6(1), ADH7(2), ADHFE1(4), AGK(3), AGPAT1(2), AGPAT2(3), AGPAT3(3), AGPAT4(2), AGPAT6(2), AKR1A1(1), AKR1B1(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), ALDH9A1(3), CEL(2), DAK(5), DGAT1(1), DGAT2(2), DGKA(4), DGKB(11), DGKD(8), DGKE(5), DGKG(6), DGKH(4), DGKI(13), DGKQ(7), DGKZ(7), GK(5), GK2(7), GLA(2), GLB1(5), GPAM(8), LCT(17), LIPA(3), LIPC(5), LIPF(1), LIPG(4), LPL(4), PNLIP(4), PNLIPRP1(7), PPAP2A(1), PPAP2B(1)	44612162	198	142	198	63	27	44	49	41	37	0	0.173	1.000	1.000
257	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	42	CBL(3), CD28(3), CD3D(1), CSK(1), CTLA4(2), DAG1(5), EPHB2(3), GRAP2(3), ITK(3), ITPKB(5), LAT(3), LCK(5), LCP2(2), NCK1(5), NFAT5(12), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(1), NFKBIE(1), NFKBIL1(1), PAK1(3), PAK2(8), PAK3(5), PAK4(1), PAK6(5), PAK7(9), PLCG1(9), PTPRC(18), RAF1(3), RASGRP1(8), RASGRP2(7), RASGRP3(9), RASGRP4(3), SOS1(9), SOS2(11), VAV1(7), ZAP70(4)	40849103	189	140	189	65	25	35	59	28	42	0	0.649	1.000	1.000
258	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	40	AKT1(2), ASAH1(1), ATF1(3), BRAF(10), CREB1(1), CREB5(7), CREBBP(37), CRKL(3), DAG1(5), EGR1(4), EGR2(5), EGR4(1), ELK1(2), FRS2(2), JUN(1), MAP1B(18), MAP2K4(2), MAP2K7(2), MAPK10(4), MAPK8(4), MAPK8IP1(4), MAPK8IP2(2), MAPK8IP3(9), MAPK9(4), NTRK1(3), OPN1LW(2), PIK3C2G(11), PIK3CD(8), PIK3R1(9), PTPN11(2), RPS6KA3(4), SHC1(2), SRC(1), TERF2IP(1), TH(3)	37056632	179	139	177	50	27	33	50	33	35	1	0.155	1.000	1.000
259	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	AANAT(1), ACAT2(2), ACMSD(6), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), AOC2(6), AOC3(5), AOX1(11), ASMT(4), CAT(4), CYP19A1(3), CYP1A1(2), CYP1A2(5), CYP2A13(4), CYP2A6(2), CYP2A7(3), CYP2B6(5), CYP2C18(3), CYP2C19(6), CYP2C8(6), CYP2C9(6), CYP2D6(4), CYP2E1(6), CYP2F1(2), CYP2J2(7), CYP3A4(4), CYP3A5(1), CYP3A7(1), CYP4B1(3), CYP51A1(1), DDC(7), ECHS1(2), EHHADH(5), GCDH(2), HAAO(1), HADHA(3), KMO(1), KYNU(9), MAOA(1), MAOB(1), SDS(1), TDO2(4), TPH1(3), WARS(2), WARS2(8)	41929402	187	138	187	63	26	40	60	31	29	1	0.452	1.000	1.000
260	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(6), ACSS2(2), ACYP1(1), ADH1A(2), ADH1B(2), ADH4(2), ADH5(3), ADH6(1), ADH7(2), ADHFE1(4), AKR1A1(1), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH3B1(3), ALDH3B2(4), ALDH7A1(2), ALDH9A1(3), ALDOA(1), ALDOB(5), ALDOC(4), DLAT(4), DLD(1), ENO1(2), ENO2(1), ENO3(3), FBP2(1), G6PC(2), G6PC2(6), GAPDH(2), GAPDHS(1), GCK(4), GPI(3), HK1(4), HK2(6), HK3(8), LDHA(1), LDHAL6A(2), LDHAL6B(6), LDHB(1), LDHC(4), PDHA1(4), PDHA2(14), PDHB(1), PFKL(6), PFKM(6), PFKP(5), PGAM1(2), PGAM2(4), PGAM4(1), PGK1(2), PGK2(5), PGM1(5), PGM3(1), PKLR(3), TPI1(4)	44294154	183	137	183	75	30	48	44	28	33	0	0.734	1.000	1.000
261	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(3), ALPL(4), ALPP(5), ALPPL2(7), ASCC3(13), ATP13A2(2), DDX18(4), DDX19A(2), DDX23(3), DDX4(4), DDX41(5), DDX47(2), DDX50(1), DDX51(3), DDX52(6), DDX54(5), DDX55(3), DDX56(4), DHFR(2), DHX58(2), ENTPD7(4), EP400(20), ERCC2(5), ERCC3(5), FPGS(1), GCH1(1), GGH(2), IFIH1(7), MOV10L1(5), NUDT5(2), NUDT8(1), QDPR(4), RAD54B(6), RAD54L(5), RUVBL2(2), SETX(13), SKIV2L2(4), SMARCA2(15), SMARCA5(2)	47925115	184	137	182	54	24	34	58	38	30	0	0.357	1.000	1.000
262	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	47	ACTA1(4), AGT(4), AKT1(2), CALM1(1), CALM2(2), CALM3(2), CALR(2), CAMK1(2), CAMK1G(2), CREBBP(37), CSNK1A1(1), EDN1(1), ELSPBP1(2), F2(3), FGF2(1), GSK3B(3), HAND1(2), HAND2(2), IGF1(1), LIF(2), MAP2K1(5), MAPK14(2), MAPK8(4), MYH2(26), NFATC1(7), NFATC2(15), NFATC3(5), NFATC4(3), NKX2-5(1), NPPA(3), PIK3R1(9), PPP3CA(2), PPP3CB(1), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), RAF1(3), RPS6KB1(4), SYT1(9)	35518398	191	137	190	64	29	43	57	29	32	1	0.283	1.000	1.000
263	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	CAD(5), CANT1(3), CTPS2(1), DCK(4), DHODH(6), DPYD(16), DPYS(7), ENTPD1(4), ITPA(4), NME2(1), NT5E(1), NUDT2(1), POLB(1), POLD1(11), POLD2(1), POLE(11), POLG(8), POLL(5), POLQ(23), POLR1B(3), POLR2A(12), POLR2B(9), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(3), POLR2G(4), POLR2H(1), POLR2I(1), POLR2J(2), POLR2L(3), POLRMT(6), RRM1(2), RRM2(1), TXNRD1(6), TYMS(1), UCK1(3), UCK2(4), UMPS(1), UNG(1), UPB1(1), UPP1(3)	43710626	183	137	183	61	27	32	58	32	34	0	0.481	1.000	1.000
264	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	56	ALG2(2), BAK1(1), BTK(8), CAD(5), CASP10(2), CASP3(2), CSNK1A1(1), DAXX(6), DEDD(1), DEDD2(5), DIABLO(1), EGFR(19), EPHB2(3), FADD(3), FAF1(2), IL1A(1), MAP2K4(2), MAP2K7(2), MAP3K1(6), MAP3K5(6), MAPK10(4), MAPK8(4), MAPK8IP1(4), MAPK8IP2(2), MAPK8IP3(9), MAPK9(4), MET(4), NFAT5(12), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(1), NFKBIE(1), NFKBIL1(1), NR0B2(1), PFN1(1), PFN2(1), PTPN13(12), RALBP1(3), RIPK1(2), ROCK1(19), TNFRSF6B(4), TPX2(5), TRAF2(2)	53581095	185	137	185	61	27	44	53	25	35	1	0.414	1.000	1.000
265	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(3), AKR1D1(3), ARSD(4), ARSE(3), CARM1(5), CYP11B1(6), CYP11B2(4), CYP19A1(3), HEMK1(1), HSD11B2(3), HSD17B1(2), HSD17B2(2), HSD17B3(2), HSD17B7(1), HSD17B8(3), HSD3B1(4), HSD3B2(4), LCMT1(2), LCMT2(6), METTL2B(3), METTL6(2), PRMT2(2), PRMT3(6), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(6), STS(4), SULT1E1(5), SULT2A1(2), UGT1A1(5), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A9(1), UGT2A1(6), UGT2A3(6), UGT2B10(11), UGT2B11(9), UGT2B15(4), UGT2B17(4), UGT2B28(6), UGT2B4(13), UGT2B7(7)	38284188	184	136	184	62	35	33	58	38	20	0	0.445	1.000	1.000
266	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	32	AKT1(2), APC(27), AR(6), ASAH1(1), BRAF(10), CCL15(1), CCL16(1), DAG1(5), EGFR(19), GNA11(4), GNA15(4), GNAI1(2), ITPKB(5), ITPR1(15), ITPR2(25), ITPR3(10), KCNJ3(9), KCNJ5(3), KCNJ9(1), MAPK10(4), MAPK14(2), PHKA2(10), PIK3CD(8), PIK3R1(9), PITX2(2), PTX3(4), RAF1(3), SRC(1)	38359170	193	136	192	62	30	43	52	36	32	0	0.258	1.000	1.000
267	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	64	APAF1(12), BAD(1), BAK1(1), BCL2(1), BCL2L1(2), BCL2L11(1), BID(3), BIRC2(3), BIRC3(2), BIRC5(1), CASP1(2), CASP10(2), CASP2(3), CASP3(2), CASP4(2), CASP6(5), CASP7(3), CASP9(1), CHUK(6), FADD(3), FAS(5), FASLG(1), GZMB(2), HELLS(6), IKBKB(11), IRF1(7), IRF2(7), IRF3(1), IRF4(4), IRF5(3), IRF6(5), IRF7(3), JUN(1), LTA(4), MAP2K4(2), MAP3K1(6), MAPK10(4), MDM2(3), MYC(6), NFKB1(5), NFKBIA(1), NFKBIB(1), NFKBIE(1), PLEKHG5(7), PRF1(5), RELA(2), RIPK1(2), TNFRSF10B(1), TNFRSF1A(2), TNFRSF1B(2), TNFRSF21(6), TNFRSF25(2), TNFSF10(1), TRADD(1), TRAF2(2), TRAF3(6)	42343644	184	135	182	54	32	49	43	21	39	0	0.0830	1.000	1.000
268	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	41	AKT1(2), AKT2(4), AKT3(6), BRAF(10), DDIT4(1), EIF4B(7), EIF4EBP1(1), FIGF(1), HIF1A(4), IGF1(1), PDPK1(4), PIK3CB(6), PIK3CD(8), PIK3CG(20), PIK3R1(9), PIK3R2(5), PIK3R3(4), PIK3R5(10), PRKAA1(4), PRKAA2(5), RHEB(1), RICTOR(9), RPS6KA1(10), RPS6KA2(6), RPS6KA3(4), RPS6KA6(8), RPS6KB1(4), RPS6KB2(2), STK11(6), TSC1(3), TSC2(7), ULK1(7), VEGFB(1), VEGFC(6)	36791741	186	135	183	53	34	39	48	29	36	0	0.142	1.000	1.000
269	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	69	ADH1A(2), ADH1B(2), ADH4(2), ADH5(3), ADH6(1), ADH7(2), ADHFE1(4), AKR1C1(1), AKR1C4(3), ALDH1A3(1), ALDH3A1(1), ALDH3B1(3), ALDH3B2(4), CYP1A1(2), CYP1A2(5), CYP1B1(5), CYP2B6(5), CYP2C18(3), CYP2C19(6), CYP2C8(6), CYP2C9(6), CYP2E1(6), CYP2F1(2), CYP2S1(1), CYP3A4(4), CYP3A43(3), CYP3A5(1), CYP3A7(1), EPHX1(2), GSTA1(3), GSTA2(1), GSTA3(2), GSTA5(2), GSTK1(2), GSTM1(1), GSTM2(2), GSTM3(1), GSTM4(4), GSTM5(1), GSTP1(1), GSTT1(1), GSTZ1(1), MGST1(1), MGST3(2), UGT1A1(5), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A9(1), UGT2A1(6), UGT2A3(6), UGT2B10(11), UGT2B11(9), UGT2B15(4), UGT2B17(4), UGT2B28(6), UGT2B4(13), UGT2B7(7)	43816385	197	134	197	84	27	38	65	38	28	1	0.942	1.000	1.000
270	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ABL1(8), ACTB(4), ACTG1(3), ARHGEF2(3), CD14(1), CDC42(3), CDH1(5), CTNNB1(6), CTTN(10), FYN(4), HCLS1(1), ITGB1(15), KRT18(1), LY96(2), NCK1(5), NCK2(7), NCL(4), OCLN(1), PRKCA(7), ROCK1(19), ROCK2(11), TLR4(17), TLR5(3), TUBA1B(5), TUBA3C(10), TUBA3D(3), TUBA3E(6), TUBA4A(1), TUBA8(2), TUBAL3(3), TUBB(2), TUBB1(3), TUBB2A(1), TUBB3(1), TUBB6(4), TUBB8(3), WAS(2), WASL(2), YWHAQ(3), YWHAZ(2)	39728526	193	134	190	76	29	45	59	25	34	1	0.730	1.000	1.000
271	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ABL1(8), ACTB(4), ACTG1(3), ARHGEF2(3), CD14(1), CDC42(3), CDH1(5), CTNNB1(6), CTTN(10), FYN(4), HCLS1(1), ITGB1(15), KRT18(1), LY96(2), NCK1(5), NCK2(7), NCL(4), OCLN(1), PRKCA(7), ROCK1(19), ROCK2(11), TLR4(17), TLR5(3), TUBA1B(5), TUBA3C(10), TUBA3D(3), TUBA3E(6), TUBA4A(1), TUBA8(2), TUBAL3(3), TUBB(2), TUBB1(3), TUBB2A(1), TUBB3(1), TUBB6(4), TUBB8(3), WAS(2), WASL(2), YWHAQ(3), YWHAZ(2)	39728526	193	134	190	76	29	45	59	25	34	1	0.730	1.000	1.000
272	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG1(3), ACTG2(5), ACTR2(1), AKT1(2), ANGPTL2(3), CDC42(3), CFL1(2), FLNA(24), FLNC(19), FSCN1(3), FSCN2(1), FSCN3(6), GDI1(5), GDI2(5), LIMK1(5), MYH2(26), MYLK(8), MYLK2(5), PAK1(3), PAK2(8), PAK3(5), PAK4(1), PAK6(5), PAK7(9), PFN1(1), PFN2(1), RHO(3), ROCK1(19), ROCK2(11), VASP(1), WASF1(3), WASL(2)	36527951	198	134	198	77	32	48	56	28	34	0	0.620	1.000	1.000
273	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	22	IMPA1(2), INPP1(2), INPP4A(8), INPP4B(11), INPP5A(3), INPPL1(8), ITPKB(5), MIOX(4), OCRL(3), PIK3C2A(6), PIK3C2B(8), PIK3C2G(11), PIK3CB(6), PIK3CG(20), PLCB1(22), PLCB2(6), PLCB3(9), PLCB4(16), PLCD1(5), PLCG1(9), PLCG2(9)	32455913	173	133	168	47	34	28	54	30	27	0	0.0800	1.000	1.000
274	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	30	AKT1(2), AKT2(4), AKT3(6), BCR(2), BTK(8), CD19(4), FLOT1(2), FLOT2(3), GAB1(5), ITPR1(15), ITPR2(25), ITPR3(10), LYN(8), NR0B2(1), PDK1(3), PHF11(1), PITX2(2), PLCG2(9), PPP1R13B(2), PREX1(14), PTPRC(18), RPS6KA1(10), RPS6KA2(6), RPS6KA3(4), RPS6KB1(4), SAG(1), SYK(8), TEC(2), VAV1(7)	39219799	186	133	185	67	28	46	40	38	33	1	0.489	1.000	1.000
275	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	23	BRCA1(12), CARM1(5), CCND1(3), CREBBP(37), ERCC3(5), ESR1(5), GRIP1(12), GTF2A1(4), GTF2E1(7), GTF2F1(4), HDAC1(1), HDAC2(3), HDAC3(4), HDAC4(11), HDAC5(3), HDAC6(7), NCOR2(22), NR0B1(5), NRIP1(8), PELP1(2), POLR2A(12), TBP(2)	30624887	174	128	173	58	19	33	52	36	33	1	0.459	1.000	1.000
276	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	46	AADAT(3), AASDHPPT(3), AASS(3), ACAT2(2), AKR1B10(4), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), ALDH9A1(3), BBOX1(2), DLST(6), DOT1L(9), ECHS1(2), EHHADH(5), EHMT1(7), EHMT2(10), GCDH(2), HADH(4), HADHA(3), HSD17B10(1), HSD17B4(5), HSD3B7(2), OGDH(10), OGDHL(11), PIPOX(2), PLOD1(4), PLOD2(9), PLOD3(4), RDH11(2), RDH12(4), SETD1A(10), SETD7(4), SETDB1(9), SHMT1(1), SHMT2(3), SPCS1(2), SPCS3(1), SUV39H1(4), SUV39H2(2), TMLHE(2)	40036938	172	128	172	68	34	31	46	33	28	0	0.733	1.000	1.000
277	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	37	AKT1(2), AKT2(4), AKT3(6), BAD(1), BCR(2), BLNK(4), BTK(8), CD19(4), CSK(1), DAG1(5), EPHB2(3), ITPKB(5), LYN(8), MAP2K1(5), MAP2K2(6), NFAT5(12), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(1), NFKBIE(1), NFKBIL1(1), PI3(2), PIK3CD(8), PIK3R1(9), PLCG2(9), PPP1R13B(2), RAF1(3), SERPINA4(7), SHC1(2), SOS1(9), SOS2(11), SYK(8), VAV1(7)	38116453	167	128	167	55	33	29	44	28	32	1	0.393	1.000	1.000
278	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	41	BCL2(1), CHUK(6), DAXX(6), EGF(8), EGFR(19), ETS1(5), ETS2(7), FOS(6), HOXA7(4), IKBKB(11), JUN(1), MAP2K1(5), MAP2K3(5), MAP2K4(2), MAP2K6(1), MAP2K7(2), MAP3K1(6), MAP3K5(6), MAPK13(3), MAPK14(2), MAPK8(4), NFKB1(5), NFKBIA(1), PRKCA(7), PRKCD(4), PRKCE(3), PRKCG(14), PRKCH(4), PRKCQ(8), RAF1(3), RELA(2), RIPK1(2), SP1(3), TNFRSF1A(2), TNFRSF1B(2), TRAF2(2)	36771633	172	126	172	68	27	37	53	26	28	1	0.750	1.000	1.000
279	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(35), B3GALT4(3), CDR1(6), DGKI(13), IL6ST(5), MRPL19(2), PIGK(6), RPL10(3), RPL12(1), RPL13A(2), RPL15(1), RPL17(1), RPL18A(1), RPL22(2), RPL23(1), RPL26(1), RPL27(1), RPL3(5), RPL31(2), RPL32(1), RPL36(2), RPL37(2), RPL39(1), RPL3L(1), RPL4(1), RPL5(2), RPL6(2), RPL7A(1), RPL8(1), RPLP0(4), RPLP2(1), RPS10(2), RPS13(2), RPS15(1), RPS19(1), RPS20(1), RPS23(1), RPS25(2), RPS27A(1), RPS28(1), RPS3(2), RPS5(1), RPS6KA1(10), RPS6KA2(6), RPS6KA3(4), RPS6KA6(8), RPS6KB1(4), RPS6KB2(2), SLC36A2(3), TBC1D10C(3), TSPAN9(1), UBA52(3), UBB(1), UBC(5)	39912118	175	126	175	75	20	40	65	23	27	0	0.960	1.000	1.000
280	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(9), ATP4A(5), ATP4B(2), ATP5A1(1), ATP5B(2), ATP5C1(1), ATP5F1(1), ATP5G1(1), ATP5G2(2), ATP5G3(1), ATP5H(1), ATP5J(2), ATP5L(1), ATP6AP1(2), ATP6V0A1(4), ATP6V0A2(3), ATP6V0A4(6), ATP6V0B(1), ATP6V0C(1), ATP6V0D1(2), ATP6V0D2(3), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(4), ATP6V1C1(4), ATP6V1C2(3), ATP6V1D(2), ATP6V1E1(2), ATP6V1E2(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(3), ATP6V1H(3), COX10(3), COX15(4), COX17(2), COX4I2(1), COX5A(2), COX5B(1), COX7B2(2), COX8A(1), CYC1(3), LHPP(1), NDUFA1(1), NDUFA12(1), NDUFA13(2), NDUFA2(1), NDUFA3(1), NDUFA5(3), NDUFA7(2), NDUFA9(3), NDUFB10(1), NDUFB2(2), NDUFB3(2), NDUFB4(1), NDUFB6(1), NDUFB8(2), NDUFB9(2), NDUFS1(1), NDUFS2(3), NDUFS3(2), NDUFS4(1), NDUFS5(3), NDUFS7(2), NDUFS8(2), NDUFV1(3), NDUFV3(1), PPA1(1), SDHA(6), SDHB(1), SDHC(1), TCIRG1(7), UQCRC1(1), UQCRC2(1), UQCRFS1(4)	42504142	165	125	164	45	18	35	54	32	26	0	0.119	1.000	1.000
281	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(2), ADH1B(2), ADH4(2), ADH6(1), ADH7(2), ADHFE1(4), AGPAT1(2), AGPAT2(3), AGPAT3(3), AGPAT4(2), AKR1A1(1), AKR1B1(2), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), CEL(2), DGAT1(1), DGKA(4), DGKB(11), DGKD(8), DGKE(5), DGKG(6), DGKH(4), DGKQ(7), DGKZ(7), GK(5), GLA(2), GLB1(5), LCT(17), LIPC(5), LIPF(1), LIPG(4), LPL(4), PNLIP(4), PNLIPRP1(7), PPAP2A(1), PPAP2B(1)	36655248	161	123	161	54	22	31	41	31	36	0	0.335	1.000	1.000
282	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ADH1A(2), ADH1B(2), ADH4(2), ADH5(3), ADH6(1), ADH7(2), ADHFE1(4), ALDH1A3(1), ALDH3A1(1), ALDH3B1(3), ALDH3B2(4), AOC2(6), AOC3(5), AOX1(11), CARM1(5), COMT(1), DBH(8), DCT(3), DDC(7), ECH1(2), ESCO1(4), ESCO2(3), FAH(2), GOT1(1), GOT2(2), GSTZ1(1), HEMK1(1), HGD(4), HPD(3), LCMT1(2), LCMT2(6), MAOA(1), MAOB(1), METTL2B(3), METTL6(2), PNMT(1), PRMT2(2), PRMT3(6), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(6), SH3GLB1(1), TAT(2), TH(3), TPO(12), TYR(8), TYRP1(4)	45290323	162	123	161	52	27	40	46	22	27	0	0.215	1.000	1.000
283	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(10), COL4A2(9), COL4A3(18), COL4A4(14), COL4A5(14), COL4A6(4), F10(3), F11(2), F12(2), F2(3), F2R(4), F5(19), F8(7), F9(8), FGA(12), FGB(4), FGG(6), KLKB1(9), PROC(2), PROS1(10), SERPINC1(4), SERPING1(5)	33810396	169	122	168	54	16	51	47	30	25	0	0.567	1.000	1.000
284	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	ACHE(2), AGPAT1(2), AGPAT2(3), AGPAT3(3), AGPAT4(2), AGPAT6(2), CDIPT(1), CDS1(3), CDS2(3), CHAT(9), CHKB(1), CHPT1(2), CRLS1(1), DGKA(4), DGKB(11), DGKD(8), DGKE(5), DGKG(6), DGKH(4), DGKI(13), DGKQ(7), DGKZ(7), ESCO1(4), ESCO2(3), ETNK1(1), ETNK2(3), GNPAT(5), GPAM(8), GPD1(1), GPD2(5), LCAT(2), LYPLA1(1), LYPLA2(1), PCYT1A(2), PCYT1B(2), PHOSPHO1(1), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PLD1(15), PLD2(1), PPAP2A(1), PPAP2B(1), PTDSS1(7), PTDSS2(2), SH3GLB1(1)	49892679	183	121	183	55	19	39	52	29	44	0	0.212	1.000	1.000
285	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	37	AKT1(2), ATF2(1), CDC42(3), DLD(1), DUSP10(3), DUSP4(1), DUSP8(1), GAB1(5), GADD45A(1), GCK(4), IL1R1(4), JUN(1), MAP2K4(2), MAP2K5(3), MAP2K7(2), MAP3K1(6), MAP3K10(5), MAP3K11(2), MAP3K12(8), MAP3K13(15), MAP3K2(2), MAP3K3(2), MAP3K4(14), MAP3K5(6), MAP3K7(8), MAP3K9(9), MAPK10(4), MAPK7(6), MAPK8(4), MAPK9(4), MYEF2(8), NFATC3(5), NR2C2(1), PAPPA(13), SHC1(2), TRAF6(3), ZAK(5)	37853259	166	121	163	44	23	37	57	25	24	0	0.147	1.000	1.000
286	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT1(2), AKT2(4), AKT3(6), ANKRD6(4), APC(27), AXIN1(12), AXIN2(7), CER1(1), CSNK1A1(1), CTNNB1(6), DACT1(6), DKK1(2), DKK2(5), DKK3(2), DVL1(8), FSTL1(3), GSK3A(2), GSK3B(3), LRP1(33), MVP(4), NKD1(8), NKD2(3), PIN1(1), PTPRA(2), SENP2(3), SFRP1(2), TSHB(2), WIF1(1)	30830754	160	121	159	54	24	38	41	31	25	1	0.400	1.000	1.000
287	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BTK(8), CALM1(1), CALM2(2), CALM3(2), ELK1(2), FCER1A(4), FOS(6), JUN(1), LYN(8), MAP2K1(5), MAP2K4(2), MAP2K7(2), MAP3K1(6), MAPK8(4), NFATC1(7), NFATC2(15), NFATC3(5), NFATC4(3), PAK2(8), PIK3R1(9), PLA2G4A(3), PLCG1(9), PPP3CA(2), PPP3CB(1), RAF1(3), SHC1(2), SOS1(9), SYK(8), SYT1(9), VAV1(7)	30292716	153	120	153	41	26	25	45	29	27	1	0.189	1.000	1.000
288	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	34	CALM1(1), CALM2(2), CALM3(2), CAMK1(2), CAMK1G(2), ELK1(2), FPR1(6), GNA15(4), GNB1(3), MAP2K1(5), MAP2K2(6), MAP2K3(5), MAP2K6(1), MAP3K1(6), MAPK14(2), NCF1(2), NCF2(6), NFATC1(7), NFATC2(15), NFATC3(5), NFATC4(3), NFKB1(5), NFKBIA(1), PAK1(3), PIK3C2G(11), PLCB1(22), PPP3CA(2), PPP3CB(1), RAF1(3), RELA(2), SYT1(9)	27988381	146	119	144	49	30	22	51	22	21	0	0.522	1.000	1.000
289	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	ALOX12(3), ALOX12B(4), ALOX15B(6), ALOX5(5), CBR3(1), CYP2B6(5), CYP2C18(3), CYP2C19(6), CYP2C8(6), CYP2C9(6), CYP2E1(6), CYP2J2(7), CYP4A11(12), CYP4A22(9), CYP4F2(6), CYP4F3(2), DHRS4(2), EPHX2(4), GGT1(4), GPX2(1), GPX5(2), GPX6(3), GPX7(1), LTA4H(2), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PTGDS(2), PTGES2(1), PTGIS(7), PTGS1(7), PTGS2(3), TBXAS1(5)	29663622	148	118	148	55	20	31	46	23	27	1	0.463	1.000	1.000
290	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	21	ADRB1(3), AKT1(2), APC(27), ASAH1(1), DAG1(5), DLG4(3), EPHB2(3), GNAI1(2), ITPR1(15), ITPR2(25), ITPR3(10), KCNJ3(9), KCNJ5(3), KCNJ9(1), PITX2(2), PTX3(4), RHO(3), RYR1(34)	33993612	152	118	151	60	30	34	38	23	27	0	0.525	1.000	1.000
291	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	38	CALM1(1), CALM2(2), CALM3(2), CD3D(1), ELK1(2), FOS(6), FYN(4), JUN(1), LAT(3), LCK(5), MAP2K1(5), MAP2K4(2), MAP3K1(6), MAPK8(4), NFATC1(7), NFATC2(15), NFATC3(5), NFATC4(3), NFKB1(5), NFKBIA(1), PIK3R1(9), PLCG1(9), PPP3CA(2), PPP3CB(1), PRKCA(7), PTPN7(4), RAF1(3), RELA(2), SHC1(2), SOS1(9), SYT1(9), VAV1(7), ZAP70(4)	32599433	148	118	148	41	27	25	44	22	30	0	0.174	1.000	1.000
292	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(2), AGPAT1(2), AGPAT2(3), AGPAT3(3), AGPAT4(2), AGPS(5), CDIPT(1), CDS1(3), CDS2(3), CHAT(9), CHKB(1), CLC(3), CPT1B(4), DGKA(4), DGKB(11), DGKD(8), DGKE(5), DGKG(6), DGKH(4), DGKQ(7), DGKZ(7), ETNK1(1), GNPAT(5), GPD1(1), GPD2(5), LCAT(2), LGALS13(1), LYPLA1(1), LYPLA2(1), PAFAH1B1(2), PAFAH2(1), PCYT1A(2), PCYT1B(2), PLA2G1B(2), PLA2G2A(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PLCB2(6), PLCG1(9), PLCG2(9), PPAP2A(1), PPAP2B(1)	38034000	156	117	156	51	21	26	47	26	36	0	0.335	1.000	1.000
293	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ADH1A(2), ADH1B(2), ADH4(2), ADH6(1), ADH7(2), ADHFE1(4), AKR1A1(1), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH3B1(3), ALDH3B2(4), ALDH9A1(3), ALDOA(1), ALDOB(5), ALDOC(4), DLAT(4), DLD(1), ENO1(2), ENO2(1), ENO3(3), FBP2(1), G6PC(2), GAPDH(2), GCK(4), GPI(3), HK1(4), HK2(6), HK3(8), LDHA(1), LDHB(1), LDHC(4), PDHA1(4), PDHA2(14), PDHB(1), PFKM(6), PFKP(5), PGAM1(2), PGK1(2), PGM1(5), PGM3(1), PKLR(3), TPI1(4)	37207275	150	116	150	56	23	38	37	24	28	0	0.576	1.000	1.000
294	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ADH1A(2), ADH1B(2), ADH4(2), ADH6(1), ADH7(2), ADHFE1(4), AKR1A1(1), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH3B1(3), ALDH3B2(4), ALDH9A1(3), ALDOA(1), ALDOB(5), ALDOC(4), DLAT(4), DLD(1), ENO1(2), ENO2(1), ENO3(3), FBP2(1), G6PC(2), GAPDH(2), GCK(4), GPI(3), HK1(4), HK2(6), HK3(8), LDHA(1), LDHB(1), LDHC(4), PDHA1(4), PDHA2(14), PDHB(1), PFKM(6), PFKP(5), PGAM1(2), PGK1(2), PGM1(5), PGM3(1), PKLR(3), TPI1(4)	37207275	150	116	150	56	23	38	37	24	28	0	0.576	1.000	1.000
295	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(16), ACACB(18), ACAT2(2), ACOT12(3), ACSS1(6), ACSS2(2), ACYP1(1), AKR1B1(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), ALDH9A1(3), DLAT(4), DLD(1), GLO1(2), GRHPR(1), HAGH(1), LDHA(1), LDHAL6A(2), LDHAL6B(6), LDHB(1), LDHC(4), LDHD(1), MDH1(1), MDH2(1), ME1(2), ME2(3), ME3(7), PC(14), PCK1(2), PCK2(4), PDHA1(4), PDHA2(14), PDHB(1), PKLR(3)	35606563	145	115	145	53	31	26	39	27	22	0	0.703	1.000	1.000
296	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	A4GALT(1), B3GALNT1(1), B3GALT1(2), B3GALT2(1), B3GALT4(3), B3GALT5(1), B3GNT1(3), B3GNT2(1), B3GNT3(6), B3GNT5(2), B4GALNT1(3), B4GALT1(1), B4GALT2(5), B4GALT3(1), B4GALT4(2), B4GALT6(2), FUT2(2), FUT3(3), FUT5(4), FUT6(2), FUT7(1), FUT9(11), GBGT1(4), GCNT2(5), PIGA(2), PIGB(3), PIGC(2), PIGG(6), PIGK(6), PIGN(3), PIGO(4), PIGP(1), PIGQ(4), PIGS(3), PIGT(2), PIGU(1), PIGV(1), PIGX(2), PIGZ(2), ST3GAL1(2), ST3GAL2(1), ST3GAL3(4), ST3GAL4(1), ST3GAL5(5), ST3GAL6(4), ST6GALNAC3(8), ST6GALNAC5(4), ST6GALNAC6(4), ST8SIA1(3), ST8SIA5(7), UGCG(1)	37034758	153	115	151	59	30	37	49	18	19	0	0.421	1.000	1.000
297	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	26	ARHGDIB(1), CASP10(2), CASP3(2), CASP6(5), CASP7(3), CFLAR(2), DAXX(6), FADD(3), FAF1(2), JUN(1), LMNA(1), LMNB1(2), LMNB2(8), MAP2K4(2), MAP3K1(6), MAP3K7(8), MAPK8(4), PAK1(3), PAK2(8), PRKDC(28), PTPN13(12), RB1(17), RIPK2(6), SPTAN1(23)	30249903	155	114	154	39	18	34	44	24	35	0	0.171	1.000	1.000
298	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(2), AKT2(4), AKT3(6), ARHGEF11(3), BCL2(1), CDC42(3), DLG4(3), GNA13(2), LPA(17), MAP2K4(2), MAP3K1(6), MAP3K5(6), MAPK8(4), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(1), NFKBIE(1), NFKBIL1(1), PDK1(3), PHKA2(10), PI3(2), PIK3CB(6), PLD1(15), PLD2(1), PLD3(2), PTK2(8), RDX(1), ROCK1(19), ROCK2(11), SERPINA4(7), SRF(1), TBXA2R(1)	37471753	160	114	159	59	12	42	50	26	30	0	0.759	1.000	1.000
299	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA2(1), ACADL(4), ACADM(3), ACADS(2), ACADSB(3), ACADVL(5), ACAT2(2), ACOX1(2), ACOX3(1), ACSL1(3), ACSL3(3), ACSL4(6), ACSL5(5), ACSL6(2), ADH1A(2), ADH1B(2), ADH4(2), ADH5(3), ADH6(1), ADH7(2), ADHFE1(4), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), ALDH9A1(3), CPT1A(6), CPT1B(4), CPT1C(8), CPT2(7), CYP4A11(12), CYP4A22(9), ECHS1(2), EHHADH(5), GCDH(2), HADH(4), HADHA(3), HADHB(4), HSD17B10(1), HSD17B4(5)	37283483	145	112	145	50	16	34	40	31	24	0	0.503	1.000	1.000
300	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(9), AKT1(2), AKT2(4), AKT3(6), DAG1(5), ITPKB(5), ITPR1(15), ITPR2(25), ITPR3(10), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(1), NFKBIE(1), NFKBIL1(1), PDK1(3), PHKA2(10), PIK3CB(6), PITX2(2), PLD1(15), PLD2(1), PLD3(2), VN1R1(2)	34128794	136	112	136	52	15	42	31	24	24	0	0.544	1.000	1.000
301	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	39	ALK(18), AR(6), ESR1(5), ESR2(1), ESRRA(4), HNF4A(6), NPM1(2), NR0B1(5), NR1D1(1), NR1D2(3), NR1H2(3), NR1H3(1), NR1I2(4), NR1I3(1), NR2C2(1), NR2E1(7), NR2F1(3), NR2F2(8), NR2F6(1), NR3C1(6), NR4A1(2), NR4A2(4), NR5A2(4), PGR(3), PPARA(2), PPARD(3), PPARG(1), RARA(5), RARB(6), ROR1(9), RORA(3), RORC(3), RXRA(4), RXRB(3), RXRG(7), THRA(5), THRB(1), VDR(2)	31342395	153	111	151	51	27	26	50	22	27	1	0.426	1.000	1.000
302	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	32	BLNK(4), BTK(8), CALM1(1), CALM2(2), CALM3(2), CD79A(1), ELK1(2), FOS(6), JUN(1), LYN(8), MAP2K1(5), MAP3K1(6), MAPK14(2), MAPK8(4), NFATC1(7), NFATC2(15), NFATC3(5), NFATC4(3), PLCG1(9), PPP3CA(2), PPP3CB(1), PRKCA(7), RAF1(3), SHC1(2), SOS1(9), SYK(8), SYT1(9), VAV1(7)	28496873	139	110	139	36	26	25	40	25	22	1	0.0772	1.000	1.000
303	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	ANKHD1(16), EEF1A2(3), EEF1B2(1), EEF1D(1), EEF1G(2), EEF2(5), EEF2K(5), EIF1AX(1), EIF2AK1(8), EIF2AK2(1), EIF2AK3(7), EIF2B1(1), EIF2B2(3), EIF2B3(4), EIF2B4(5), EIF2B5(6), EIF2S1(2), EIF2S2(6), EIF2S3(1), EIF4A1(3), EIF4A2(2), EIF4E(1), EIF4EBP1(1), EIF4G1(20), EIF4G3(8), EIF5(3), EIF5A(5), EIF5B(6), ETF1(2), GSPT2(6), PABPC1(1), PABPC3(7), PAIP1(5), SLC35A4(1)	33415084	149	110	148	42	17	32	49	27	24	0	0.319	1.000	1.000
304	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	35	AGT(4), AGTR2(2), CALM1(1), CALM2(2), CALM3(2), CAMK2A(2), CAMK2B(3), CAMK2D(3), CAMK2G(2), CDK5(3), F2(3), FYN(4), GNA11(4), GNAI1(2), GNB1(3), JAK2(5), MAP2K1(5), MAP2K2(6), MAPK14(2), MAPK8(4), MAPT(9), MYLK(8), PLCG1(9), PRKCA(7), PTK2B(4), RAF1(3), SHC1(2), SOS1(9), STAT1(8), STAT3(6), STAT5A(3), SYT1(9)	30825197	139	109	139	49	30	32	42	22	13	0	0.352	1.000	1.000
305	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOA(1), ALDOB(5), ALDOC(4), DLAT(4), DLD(1), ENO1(2), ENO2(1), ENO3(3), FBP2(1), G6PC(2), GAPDH(2), GAPDHS(1), GCK(4), GOT1(1), GOT2(2), GPI(3), HK1(4), HK2(6), HK3(8), LDHA(1), LDHAL6B(6), LDHB(1), LDHC(4), MDH1(1), MDH2(1), PC(14), PCK1(2), PDHA1(4), PDHA2(14), PDHB(1), PDHX(4), PFKL(6), PFKM(6), PFKP(5), PGAM1(2), PGAM2(4), PGK1(2), PGK2(5), PKLR(3), TNFAIP1(4), TPI1(4)	32322727	149	109	149	56	25	40	38	23	23	0	0.441	1.000	1.000
306	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	33	ADCY1(21), CALM1(1), CALM2(2), CALM3(2), CREB1(1), ELK1(2), FOS(6), GNAI1(2), GNAS(13), GNB1(3), JUN(1), MAP2K1(5), NFATC1(7), NFATC2(15), NFATC3(5), NFATC4(3), PLCG1(9), PPP3CA(2), PPP3CB(1), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), PRKCA(7), RAF1(3), RPS6KA3(4), SYT1(9)	26301904	140	109	139	37	32	27	41	22	18	0	0.0408	1.000	1.000
307	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(2), AKR1B10(4), B4GALT1(1), B4GALT2(5), G6PC(2), G6PC2(6), GAA(3), GALK1(1), GALK2(2), GALT(2), GANC(6), GCK(4), GLA(2), GLB1(5), HK1(4), HK2(6), HK3(8), HSD3B7(2), LALBA(1), LCT(17), MGAM(29), PFKL(6), PFKM(6), PFKP(5), PGM1(5), PGM3(1), RDH11(2), RDH12(4), UGP2(2)	29369150	143	109	142	34	26	32	42	20	22	1	0.00873	1.000	1.000
308	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	30	ACTA1(4), CRK(2), CRKL(3), DOCK1(15), ELK1(2), FOS(6), GAB1(5), HGF(11), ITGA1(4), ITGB1(15), JUN(1), MAP2K1(5), MAP2K2(6), MAP4K1(5), MAPK8(4), MET(4), PAK1(3), PIK3R1(9), PTK2(8), PTK2B(4), PTPN11(2), PXN(2), RAF1(3), RAP1B(3), SOS1(9), SRC(1), STAT3(6)	28914169	142	109	139	35	23	22	45	30	22	0	0.100	1.000	1.000
309	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	27	ARHGDIB(1), BAG4(7), CASP2(3), CASP3(2), CRADD(2), FADD(3), JUN(1), LMNA(1), LMNB1(2), LMNB2(8), MADD(10), MAP2K4(2), MAP3K1(6), MAP3K7(8), MAPK8(4), PAK1(3), PAK2(8), PRKDC(28), RB1(17), RIPK1(2), SPTAN1(23), TNFRSF1A(2), TRADD(1), TRAF2(2)	28801391	146	109	145	44	20	27	46	24	29	0	0.454	1.000	1.000
310	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	23	ARNT(9), EIF1(2), EIF2B1(1), EIF2B2(3), EIF2B3(4), EIF2B4(5), EIF2B5(6), EIF2S1(2), EIF2S2(6), EIF2S3(1), ELAVL1(5), FLT1(17), FLT4(14), HIF1A(4), KDR(14), NOS3(4), PIK3R1(9), PLCG1(9), PRKCA(7), PTK2(8), PXN(2), SHC1(2)	23880167	134	108	134	31	27	30	34	23	20	0	0.0341	1.000	1.000
311	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(9), GABBR1(4), GPRC5A(2), GPRC5B(2), GPRC5C(3), GPRC5D(1), GRM1(28), GRM2(9), GRM3(28), GRM4(2), GRM5(12), GRM7(20), GRM8(24)	15942015	144	107	142	44	31	29	39	30	15	0	0.0567	1.000	1.000
312	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(2), AARS2(5), CARS(4), CARS2(1), DARS(5), DARS2(3), EARS2(4), EPRS(5), FARS2(5), FARSA(1), FARSB(8), HARS(1), HARS2(2), IARS(11), IARS2(2), KARS(4), LARS(5), LARS2(2), MARS(2), MARS2(5), MTFMT(4), NARS(2), NARS2(2), PARS2(5), QARS(5), RARS(1), RARS2(3), SARS(1), TARS(6), TARS2(4), VARS(5), VARS2(4), WARS(2), WARS2(8), YARS(6), YARS2(4)	41343530	139	107	139	34	16	29	45	28	21	0	0.0631	1.000	1.000
313	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	30	ACTR2(1), AKT1(2), ANGPTL2(3), DAG1(5), DGKA(4), ETFA(3), GCA(1), ITGA9(3), ITPKB(5), ITPR1(15), ITPR2(25), ITPR3(10), MAP2K1(5), NR1I3(1), PAK1(3), PDE3A(19), PDE3B(4), PI3(2), PIK3C2G(11), PIK3CD(8), PIK3R1(9), PSME1(1), RIPK3(1), SGCB(3), VASP(1)	34812406	145	107	144	56	18	32	38	26	31	0	0.842	1.000	1.000
314	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	46	APAF1(12), BAD(1), BCL2(1), BCL2A1(2), BCL2L1(2), BCL2L2(1), BOK(1), CASP1(2), CASP10(2), CASP2(3), CASP3(2), CASP4(2), CASP6(5), CASP7(3), CASP9(1), CD40(7), CD40LG(4), CRADD(2), DAXX(6), FADD(3), FAS(5), FASLG(1), IKBKE(5), LTA(4), MCL1(3), NFKB1(5), NFKBIA(1), NGFR(1), NR3C1(6), NTRK1(3), PTPN13(12), RIPK1(2), TFG(2), TNFRSF1A(2), TNFRSF1B(2), TRADD(1), TRAF2(2), TRAF3(6), TRAF6(3)	32286019	128	106	128	36	19	36	29	21	23	0	0.131	1.000	1.000
315	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAD(2), ALAS2(4), BLVRA(3), COX10(3), COX15(4), CP(7), CPOX(1), EARS2(4), EPRS(5), FECH(1), FTMT(5), GUSB(5), HCCS(2), HMOX1(1), HMOX2(1), MMAB(1), PPOX(1), UGT1A1(5), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A9(1), UGT2A1(6), UGT2A3(6), UGT2B10(11), UGT2B11(9), UGT2B15(4), UGT2B17(4), UGT2B28(6), UGT2B4(13), UGT2B7(7), UROD(1), UROS(3)	32200935	139	106	139	63	17	22	51	35	14	0	0.991	1.000	1.000
316	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	23	CSNK2A1(7), EGF(8), EGFR(19), ELK1(2), FOS(6), JAK1(10), JUN(1), MAP2K1(5), MAP2K4(2), MAP3K1(6), MAPK8(4), PIK3R1(9), PLCG1(9), PRKCA(7), RAF1(3), SHC1(2), SOS1(9), SRF(1), STAT1(8), STAT3(6), STAT5A(3)	24982164	127	105	127	32	16	26	38	22	24	1	0.0812	1.000	1.000
317	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	27	EGFR(19), ELK1(2), GNAS(13), GNB1(3), IGF1R(11), ITGB1(15), KLK2(2), MAP2K1(5), MAP2K2(6), MKNK1(1), MKNK2(2), MYC(6), NGFR(1), PDGFRA(13), PTPRR(5), RAF1(3), RPS6KA1(10), RPS6KA5(5), SHC1(2), SOS1(9), SRC(1), STAT3(6)	24356937	140	105	137	32	35	26	46	18	15	0	0.0163	1.000	1.000
318	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(2), AARS2(5), ABAT(6), ACY3(3), ADSL(4), ADSS(4), ADSSL1(5), AGXT(2), AGXT2(5), ASL(2), ASNS(5), ASPA(4), ASRGL1(1), ASS1(2), CAD(5), CRAT(6), DARS(5), DARS2(3), DDO(2), DLAT(4), DLD(1), GAD1(4), GAD2(6), GOT1(1), GOT2(2), GPT(1), GPT2(4), NARS(2), NARS2(2), PC(14), PDHA1(4), PDHA2(14), PDHB(1)	28819861	131	105	131	43	19	34	40	19	19	0	0.285	1.000	1.000
319	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(1), ARHGAP1(4), ARHGAP4(10), ARHGAP5(10), ARHGAP6(8), ARHGEF1(8), ARHGEF11(3), ARHGEF5(4), ARPC1B(3), ARPC2(2), ARPC3(1), ARPC4(1), BAIAP2(2), CFL1(2), DIAPH1(7), GSN(5), LIMK1(5), MYLK(8), OPHN1(6), PFN1(1), PIP5K1A(3), PIP5K1B(9), PPP1R12B(4), ROCK1(19), SRC(1), TLN1(22), VCL(5)	34531628	154	105	154	63	23	35	47	32	17	0	0.917	1.000	1.000
320	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1A(5), ADRA1B(3), ADRA1D(3), ADRA2C(3), ADRB1(3), ADRB3(2), CHRM2(5), CHRM3(9), CHRM4(2), CHRM5(4), DRD1(2), DRD2(4), DRD3(6), DRD4(1), DRD5(8), HRH1(1), HRH2(3), HTR1A(9), HTR1B(8), HTR1D(2), HTR1E(8), HTR1F(4), HTR2A(5), HTR2B(2), HTR2C(4), HTR4(2), HTR5A(9), HTR6(6), HTR7(8)	19620773	131	104	131	60	35	17	40	21	18	0	0.649	1.000	1.000
321	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	20	ATM(16), ATR(24), BRCA1(12), BRCA2(17), CHEK1(1), CHEK2(4), FANCA(7), FANCC(3), FANCD2(9), FANCF(2), FANCG(2), HUS1(2), MRE11A(3), RAD17(7), RAD50(10), RAD51(1), RAD9A(2), TREX1(4)	32937946	126	103	126	30	8	38	32	27	21	0	0.160	1.000	1.000
322	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	69	CALR(2), CANX(3), CD4(1), CD74(2), CD8A(3), CD8B(2), CIITA(13), CREB1(1), CTSS(4), HLA-C(5), HLA-DMB(1), HLA-DOA(2), HLA-DOB(3), HLA-DPB1(1), HLA-DQA2(2), HLA-DQB1(2), HLA-DRA(1), HLA-DRB1(2), HLA-E(1), HLA-F(4), HLA-G(2), HSP90AA1(6), HSP90AB1(8), HSPA5(4), IFI30(1), IFNA10(1), IFNA14(1), IFNA16(4), IFNA17(3), IFNA2(1), IFNA21(2), IFNA4(3), IFNA6(1), IFNA8(3), KIR2DL3(1), KIR3DL1(3), KIR3DL3(3), KLRC1(1), KLRC2(1), KLRC3(3), KLRC4(1), LGMN(4), LTA(4), NFYC(2), PSME1(1), PSME2(2), RFX5(4), RFXAP(3), TAP1(6), TAP2(3), TAPBP(4)	33706037	141	103	140	53	16	39	39	20	27	0	0.580	1.000	1.000
323	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	33	ACTA1(4), ACTN1(4), ACTN2(10), BCAR1(3), BCR(2), CAPN1(3), CAPNS1(2), CAPNS2(2), CAV1(1), CRKL(3), CSK(1), FYN(4), ITGA1(4), ITGB1(15), JUN(1), MAP2K1(5), MAP2K2(6), MAPK8(4), PPP1R12B(4), PTK2(8), PXN(2), RAF1(3), ROCK1(19), SHC1(2), SOS1(9), SRC(1), TLN1(22), VCL(5), ZYX(2)	35151449	151	103	150	42	26	24	57	26	18	0	0.206	1.000	1.000
324	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(3), F11(2), F12(2), F13B(13), F2(3), F5(19), F7(2), F8(7), F9(8), FGA(12), FGB(4), FGG(6), LPA(17), PLAT(4), PLG(13), SERPINB2(2), SERPINE1(7), VWF(19)	26901816	143	102	142	41	14	38	43	25	23	0	0.204	1.000	1.000
325	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	ARNTL(2), AZIN1(3), BTG1(1), CBX3(1), CEBPB(1), CLOCK(6), CRY1(6), CRY2(3), DAZAP2(2), DNAJA1(3), EIF4G2(8), ETV6(6), G0S2(1), GFRA1(7), GSTM3(1), GSTP1(1), HERPUD1(5), HSPA8(10), IDI1(1), KLF9(1), MYF6(1), NCKAP1(8), NCOA4(7), NR1D2(3), PER1(7), PER2(2), PPP1R3C(1), PPP2CB(3), PSMA4(1), SF3A3(2), SUMO3(1), TUBB3(1), UCP3(5), UGP2(2), VAPA(1), ZFR(4)	27910670	118	102	118	44	16	21	44	22	15	0	0.880	1.000	1.000
326	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2A1(4), GTF2A1L(8), GTF2A2(1), GTF2B(1), GTF2E1(7), GTF2F1(4), GTF2F2(2), GTF2H1(3), GTF2H3(2), GTF2H4(3), GTF2I(4), GTF2IRD1(5), STON1(6), TAF1(12), TAF10(4), TAF13(1), TAF1L(24), TAF2(7), TAF4(5), TAF4B(4), TAF5(7), TAF5L(4), TAF6(5), TAF6L(2), TAF7(2), TAF7L(4), TAF9(3), TBPL1(2), TBPL2(1)	27445100	137	102	136	52	19	31	35	28	24	0	0.857	1.000	1.000
327	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(27), AXIN1(12), BTRC(1), CCND1(3), CREBBP(37), CSNK1A1(1), CSNK1D(1), CSNK2A1(7), CTBP1(2), CTNNB1(6), DVL1(8), FZD1(6), GSK3B(3), HDAC1(1), MAP3K7(8), MYC(6), NLK(1), PPARD(3), TLE1(7), WIF1(1), WNT1(2)	22412539	143	101	138	37	19	33	37	24	28	2	0.0819	1.000	1.000
328	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ACY3(3), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH3B1(3), ALDH3B2(4), ALDH7A1(2), ALDH9A1(3), AMDHD1(2), AOC2(6), AOC3(5), ASPA(4), CARM1(5), CNDP1(9), DDC(7), FTCD(2), HAL(6), HARS(1), HARS2(2), HDC(4), HEMK1(1), HNMT(1), LCMT1(2), LCMT2(6), MAOA(1), MAOB(1), METTL2B(3), METTL6(2), PRMT2(2), PRMT3(6), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(6), PRPS1(3), PRPS2(2), UROC1(3)	30139282	125	100	125	37	23	31	40	17	14	0	0.0783	1.000	1.000
329	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(4), POLA2(2), POLB(1), POLD1(11), POLD2(1), POLD3(4), POLE(11), POLG(8), POLG2(2), POLH(3), POLI(4), POLK(9), POLL(5), POLM(2), POLQ(23), PRIM1(3), PRIM2(1), REV1(3), REV3L(24), RFC5(2)	30859219	123	100	122	34	20	27	31	19	26	0	0.229	1.000	1.000
330	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	30	ACVR1(4), APC(27), ATF2(1), AXIN1(12), BMP10(2), BMP2(5), BMP4(4), BMP5(6), BMP7(3), BMPR2(6), CHRD(11), CTNNB1(6), DVL1(8), FZD1(6), GSK3B(3), MAP3K7(8), NKX2-5(1), NOG(2), NPPA(3), NPPB(2), RFC1(3), TGFB1(1), TGFB2(4), TGFB3(1), TGFBR1(2), TGFBR3(5), WNT1(2)	26272597	138	99	136	35	22	30	35	27	23	1	0.0786	1.000	1.000
331	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	20	ATM(16), ATR(24), BRCA1(12), CCNB1(2), CDC25A(3), CDC25B(4), CDC25C(4), CDC34(4), CDKN2D(1), CHEK1(1), CHEK2(4), GADD45A(1), MDM2(3), MYT1(11), PRKDC(28), RPS6KA1(10), WEE1(2), YWHAH(2), YWHAQ(3)	27584710	135	99	135	30	17	30	39	28	21	0	0.109	1.000	1.000
332	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(2), AKR1B10(4), ALDOA(1), ALDOB(5), ALDOC(4), FBP2(1), FPGT(6), FUK(3), GMDS(4), GMPPA(1), HK1(4), HK2(6), HK3(8), HSD3B7(2), KHK(3), LHPP(1), MPI(4), MTMR1(2), MTMR2(3), MTMR6(3), PFKFB1(3), PFKFB2(5), PFKFB3(2), PFKFB4(1), PFKL(6), PFKM(6), PFKP(5), PGM2(4), PHPT1(1), PMM2(2), RDH11(2), RDH12(4), SORD(2), TPI1(4), TSTA3(2)	28257904	116	99	116	33	23	26	32	21	14	0	0.0668	1.000	1.000
333	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(6), ACAA2(1), ACADM(3), ACADS(2), ACAT2(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH6A1(2), ALDH7A1(2), ALDH9A1(3), AOX1(11), AUH(1), BCAT1(4), BCAT2(4), BCKDHA(3), BCKDHB(4), DBT(7), DLD(1), ECHS1(2), EHHADH(5), HADH(4), HADHA(3), HADHB(4), HIBADH(1), HIBCH(2), HMGCL(1), HMGCS1(3), HMGCS2(2), HSD17B10(1), HSD17B4(5), IVD(6), MCCC1(2), MCCC2(3), MUT(5), OXCT1(1), OXCT2(1), PCCA(9), PCCB(1)	32787097	127	99	126	44	16	34	32	27	18	0	0.596	1.000	1.000
334	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	AGT(4), ATF2(1), CALM1(1), CALM2(2), CALM3(2), EGFR(19), ELK1(2), JUN(1), MAP2K1(5), MAP2K2(6), MAP2K4(2), MAP3K1(6), MAPK8(4), MEF2A(3), MEF2B(5), MEF2D(1), PAK1(3), PRKCA(7), PTK2(8), PTK2B(4), RAF1(3), SHC1(2), SOS1(9), SRC(1), SYT1(9)	23083528	110	98	110	34	17	18	41	23	11	0	0.392	1.000	1.000
335	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(3), ACTG2(5), ADCY3(7), ADCY9(9), AK1(1), ARF1(1), ARF4(1), ARF6(2), ARL4D(1), ATP6V0A1(4), ATP6V0A2(3), ATP6V0A4(6), ATP6V0B(1), ATP6V0C(1), ATP6V0D1(2), ATP6V0D2(3), ATP6V1A(2), ATP6V1C1(4), ATP6V1C2(3), ATP6V1D(2), ATP6V1E1(2), ATP6V1E2(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(3), ATP6V1H(3), ERO1L(3), GNAS(13), PDIA4(1), PLCG1(9), PLCG2(9), PRKCA(7), SEC61A1(4), SEC61A2(4), SEC61B(1), TRIM23(6)	28168025	129	98	129	36	22	28	38	23	18	0	0.0785	1.000	1.000
336	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(4), AADAC(5), ABAT(6), ACADS(2), ACAT2(2), ACSM1(6), AKR1B10(4), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH5A1(1), ALDH7A1(2), ALDH9A1(3), BDH1(1), BDH2(1), DDHD1(4), ECHS1(2), EHHADH(5), GAD1(4), GAD2(6), HADH(4), HADHA(3), HMGCL(1), HMGCS1(3), HMGCS2(2), HSD17B10(1), HSD17B4(5), HSD3B7(2), ILVBL(5), L2HGDH(4), OXCT1(1), OXCT2(1), PDHA1(4), PDHA2(14), PDHB(1), PLA1A(8), PPME1(1), PRDX6(1), RDH11(2), RDH12(4)	30901288	135	97	135	54	18	38	40	24	15	0	0.742	1.000	1.000
337	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	30	A1BG(7), AKT1(2), AKT2(4), AKT3(6), BAD(1), BTK(8), GSK3A(2), GSK3B(3), IARS(11), IGFBP1(3), INPP5D(8), PDK1(3), PPP1R13B(2), RPS6KA1(10), RPS6KA2(6), RPS6KA3(4), RPS6KB1(4), SFN(7), SHC1(2), SOS1(9), SOS2(11), TEC(2), YWHAB(2), YWHAE(2), YWHAG(1), YWHAH(2), YWHAQ(3), YWHAZ(2)	24738025	127	97	127	43	14	29	39	26	18	1	0.599	1.000	1.000
338	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	22	ACTA1(4), CAPN1(3), CAPN2(5), CAPNS1(2), CAPNS2(2), CXCR3(1), EGF(8), EGFR(19), ITGA1(4), ITGB1(15), MYLK(8), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), PTK2(8), PXN(2), TLN1(22)	24081070	119	96	117	43	23	19	36	23	17	1	0.645	1.000	1.000
339	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	ATM(16), BMPR1B(4), CCND2(2), CDK4(5), CDKN1B(2), CEBPB(1), DAZL(3), DMC1(1), EGR1(4), ESR2(1), FSHR(12), GJA4(1), INHA(2), LHCGR(9), MLH1(5), MSH5(3), NCOR1(20), NRIP1(8), PGR(3), PRLR(9), PTGER2(5), VDR(2), ZP2(6)	26702340	124	96	120	37	14	30	38	22	20	0	0.281	1.000	1.000
340	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	14	AKT1(2), BCL2(1), EGFR(19), IGF1R(11), MYC(6), POLR2A(12), PRKCA(7), RB1(17), TEP1(15), TERF1(5), TERT(3), TNKS(7), XRCC5(4)	20921990	109	96	107	38	13	30	27	17	21	1	0.336	1.000	1.000
341	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(6), ACACA(16), ACACB(18), ACADM(3), ACAT2(2), ACSS1(6), ACSS2(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH6A1(2), ALDH7A1(2), ALDH9A1(3), ECHS1(2), EHHADH(5), HADHA(3), HIBCH(2), LDHA(1), LDHAL6A(2), LDHAL6B(6), LDHB(1), LDHC(4), MLYCD(2), MUT(5), PCCA(9), PCCB(1), SUCLA2(2), SUCLG1(1), SUCLG2(3)	30231670	119	95	119	43	24	21	33	23	18	0	0.724	1.000	1.000
342	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(21), CD3D(1), CD4(1), CREBBP(37), CSK(1), GNAS(13), GNB1(3), HLA-DRA(1), HLA-DRB1(2), LCK(5), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), PTPRC(18), ZAP70(4)	17536351	123	94	120	38	21	24	33	20	24	1	0.261	1.000	1.000
343	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(21), CD3D(1), CD4(1), CREBBP(37), CSK(1), GNAS(13), GNB1(3), HLA-DRA(1), HLA-DRB1(2), LCK(5), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), PTPRC(18), ZAP70(4)	17536351	123	94	120	38	21	24	33	20	24	1	0.261	1.000	1.000
344	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(2), CDC7(1), CDT1(1), DIAPH2(10), GMNN(3), MCM10(6), MCM2(5), MCM3(4), MCM4(7), MCM5(2), MCM6(4), MCM7(8), NACA(24), PCNA(1), POLA2(2), POLD1(11), POLD2(1), POLD3(4), POLE(11), PRIM1(3), RFC1(3), RFC2(3), RFC3(2), RFC4(4), RFC5(2), RPA1(5), RPA2(1), RPA4(1), RPS27A(1), UBA52(3), UBB(1), UBC(5)	38615851	141	94	140	50	16	36	47	18	23	1	0.805	1.000	1.000
345	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	25	AKT1(2), APC(27), AXIN1(12), CCND1(3), CD14(1), CTNNB1(6), DVL1(8), FZD1(6), GJA1(2), GNAI1(2), GSK3B(3), IRAK1(3), LBP(7), LEF1(5), LY96(2), NFKB1(5), PDPK1(4), PIK3R1(9), RELA(2), TIRAP(1), TLR4(17), TOLLIP(2), WNT1(2)	21852761	131	94	129	41	20	31	33	19	27	1	0.263	1.000	1.000
346	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(7), ADRBK2(5), ARRB2(1), CALM1(1), CALM2(2), CALM3(2), CALML3(1), CAMK2A(2), CAMK2B(3), CAMK2D(3), CAMK2G(2), CLCA1(6), CLCA2(6), CLCA4(6), CNGA3(9), CNGA4(5), CNGB1(13), GNAL(4), GUCA1C(1), PDC(2), PDE1C(14), PRKACA(4), PRKACB(3), PRKACG(2), PRKG1(7), PRKG2(2), PRKX(1)	23255489	114	93	114	44	16	26	34	23	15	0	0.608	1.000	1.000
347	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	23	CSNK2A1(7), ELK1(2), FOS(6), JAK1(10), JUN(1), MAP2K1(5), MAP2K4(2), MAP3K1(6), MAPK8(4), PDGFRA(13), PIK3R1(9), PLCG1(9), PRKCA(7), RAF1(3), SHC1(2), SOS1(9), SRF(1), STAT1(8), STAT3(6), STAT5A(3)	23029212	113	93	113	27	16	24	35	15	23	0	0.0576	1.000	1.000
348	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	13	APC(27), AXIN1(12), CREBBP(37), CTNNB1(6), DVL1(8), FZD1(6), GSK3B(3), HDAC1(1), LDB1(2), LEF1(5), PITX2(2), TRRAP(22), WNT1(2)	21559222	133	93	131	32	24	29	31	26	21	2	0.0183	1.000	1.000
349	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	25	AKT1(2), AKT2(4), AKT3(6), CISH(1), IARS(11), IL13RA1(2), IL4(1), IL4R(8), INPP5D(8), JAK1(10), JAK2(5), JAK3(6), NR0B2(1), PI3(2), PPP1R13B(2), RPS6KB1(4), SERPINA4(7), SHC1(2), SOS1(9), SOS2(11), SRC(1), STAT6(5), TYK2(8)	26448405	116	93	116	44	16	23	39	24	14	0	0.718	1.000	1.000
350	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	20	CDK5(3), CDK5R1(1), CFL1(2), CHN1(7), LIMK1(5), MAP3K1(6), MYLK(8), NCF2(6), PAK1(3), PDGFRA(13), PIK3R1(9), PLD1(15), PPP1R12B(4), RALBP1(3), RPS6KB1(4), TRIO(20), VAV1(7), WASF1(3)	24623023	119	92	119	55	19	27	38	13	22	0	0.983	1.000	1.000
351	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	19	ARHGAP5(10), DIAPH1(7), FYN(4), GSN(5), ITGA1(4), ITGB1(15), MAP2K1(5), MYLK(8), PFN1(1), PIK3R1(9), PTK2(8), PXN(2), RAF1(3), ROCK1(19), SHC1(2), SRC(1), TLN1(22)	25945350	125	91	124	36	20	19	35	28	23	0	0.416	1.000	1.000
352	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM1(1), CALM2(2), CALM3(2), DLG4(3), GRIN1(4), GRIN2A(21), GRIN2B(22), GRIN2C(7), GRIN2D(6), NOS1(9), PPP3CA(2), PPP3CB(1), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), PRKCA(7), SYT1(9)	19495200	112	91	112	41	21	28	30	19	14	0	0.234	1.000	1.000
353	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(16), ACAT2(2), ACYP1(1), ADH5(3), AKR1B1(2), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), DLAT(4), DLD(1), GLO1(2), GRHPR(1), HAGH(1), LDHA(1), LDHB(1), LDHC(4), LDHD(1), MDH1(1), MDH2(1), ME1(2), ME2(3), ME3(7), PC(14), PCK1(2), PDHA1(4), PDHA2(14), PDHB(1), PKLR(3)	28133165	116	91	116	40	22	24	32	22	16	0	0.587	1.000	1.000
354	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CD14(1), CHUK(6), ELK1(2), FOS(6), IKBKB(11), IRAK1(3), JUN(1), LY96(2), MAP2K3(5), MAP2K4(2), MAP2K6(1), MAP3K1(6), MAP3K7(8), MAPK14(2), MAPK8(4), NFKB1(5), NFKBIA(1), PPARA(2), RELA(2), TIRAP(1), TLR10(5), TLR2(2), TLR3(1), TLR4(17), TLR6(3), TLR7(8), TLR9(4), TOLLIP(2), TRAF6(3)	27836421	116	91	115	48	17	25	40	14	20	0	0.843	1.000	1.000
355	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	AGMAT(2), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), AMD1(4), AOC2(6), AOC3(5), ARG1(1), ARG2(1), ASL(2), CKB(4), CKM(3), CKMT1B(2), CPS1(14), DAO(1), GAMT(2), GATM(4), GLUD1(3), GOT1(1), GOT2(2), MAOA(1), MAOB(1), NOS1(9), NOS3(4), OAT(1), ODC1(3), OTC(2), P4HA1(4), P4HA2(3), P4HA3(1), P4HB(1), PYCR1(1), RARS(1), SMS(3)	33655833	116	90	116	42	23	25	30	22	16	0	0.534	1.000	1.000
356	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	15	C3(15), C5(10), C7(12), ICAM1(6), IL1A(1), IL6(2), ITGA4(14), ITGAL(8), ITGB1(15), ITGB2(3), SELP(16), SELPLG(3), VCAM1(10)	17430493	115	90	114	36	11	31	33	20	20	0	0.222	1.000	1.000
357	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(9), ATP4B(2), ATP6AP1(2), ATP6V0A1(4), ATP6V0A4(6), ATP6V0B(1), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(4), ATP6V1C1(4), ATP6V1C2(3), ATP6V1D(2), ATP6V1E1(2), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(3), ATP6V1H(3), ATP7A(12), ATP7B(8), COX10(3), COX5A(2), COX5B(1), COX8A(1), NDUFA1(1), NDUFA5(3), NDUFB2(2), NDUFB4(1), NDUFB6(1), NDUFS1(1), NDUFS2(3), NDUFV1(3), SDHA(6), SDHB(1), SHMT1(1), UQCRC1(1), UQCRFS1(4)	29048108	110	90	108	29	17	27	32	24	10	0	0.0767	1.000	1.000
358	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	36	ATF2(1), CDC42(3), CREB1(1), DAXX(6), ELK1(2), HSPB2(2), MAP2K4(2), MAP2K6(1), MAP3K1(6), MAP3K5(6), MAP3K7(8), MAP3K9(9), MAPK14(2), MAPKAPK5(2), MAX(1), MEF2A(3), MEF2B(5), MEF2D(1), MKNK1(1), MYC(6), PLA2G4A(3), RIPK1(2), RPS6KA5(5), SHC1(2), STAT1(8), TGFB1(1), TGFB2(4), TGFB3(1), TGFBR1(2), TRADD(1), TRAF2(2)	26553627	99	90	96	35	16	23	29	14	17	0	0.660	1.000	1.000
359	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	19	CCR3(5), CFL1(2), GNAS(13), GNB1(3), LIMK1(5), MAP2K1(5), NOX1(6), PIK3C2G(11), PLCB1(22), PPP1R12B(4), PRKCA(7), PTK2(8), RAF1(3), ROCK2(11)	18339009	105	89	103	32	18	19	40	12	16	0	0.492	1.000	1.000
360	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	28	AKT1(2), AVP(1), CABIN1(14), CALM1(1), CALM2(2), CALM3(2), CAMK1(2), CAMK1G(2), HDAC5(3), IGF1(1), IGF1R(11), INSR(3), MAP2K6(1), MAPK14(2), MAPK7(6), MEF2A(3), MEF2B(5), MEF2D(1), MYOD1(2), NFATC1(7), NFATC2(15), PIK3R1(9), PPP3CA(2), PPP3CB(1), SYT1(9), YWHAH(2)	24217788	109	89	109	41	19	23	26	26	15	0	0.434	1.000	1.000
361	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(6), ALDH5A1(1), CAD(5), CPS1(14), EARS2(4), EPRS(5), GAD1(4), GAD2(6), GCLC(4), GCLM(1), GFPT1(3), GFPT2(5), GLS(1), GLS2(2), GLUD1(3), GLUD2(10), GLUL(3), GMPS(7), GNPNAT1(1), GOT1(1), GOT2(2), GPT(1), GPT2(4), GSS(3), NADSYN1(3), PPAT(3), QARS(5)	30115190	107	89	107	53	18	23	27	20	19	0	0.973	1.000	1.000
362	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	34	AKT1(2), ATF1(3), CDC42(3), CREB1(1), CREB5(7), DUSP1(2), DUSP10(3), EEF2K(5), EIF4E(1), ELK1(2), GADD45A(1), IL1R1(4), MAP2K3(5), MAP2K4(2), MAP2K6(1), MAP3K10(5), MAP3K4(14), MAP3K5(6), MAP3K7(8), MAPK11(3), MAPK12(3), MAPK13(3), MAPK14(2), MAPKAPK5(2), MKNK1(1), MKNK2(2), MYEF2(8), NFKB1(5), NR2C2(1), SRF(1), TRAF6(3)	24904271	109	89	107	35	14	24	32	22	17	0	0.431	1.000	1.000
363	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA2(1), ACADL(4), ACADM(3), ACADS(2), ACADSB(3), ACAT2(2), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH6A1(2), ALDH9A1(3), AOX1(11), BCAT1(4), BCKDHA(3), BCKDHB(4), ECHS1(2), EHHADH(5), HADHA(3), HADHB(4), HIBADH(1), HMGCL(1), IVD(6), MCCC1(2), MCCC2(3), MUT(5), OXCT1(1), PCCA(9), PCCB(1), SDS(1)	27435349	107	89	106	36	11	23	30	25	18	0	0.675	1.000	1.000
364	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(6), CALCR(4), CALCRL(5), CD97(5), CRHR1(3), CRHR2(4), ELTD1(11), EMR1(7), EMR2(2), GHRHR(3), GIPR(2), GLP1R(1), GLP2R(5), GPR64(6), LPHN1(11), LPHN2(10), LPHN3(22), SCTR(2), VIPR1(1), VIPR2(5)	20287718	115	88	115	39	15	15	34	35	16	0	0.468	1.000	1.000
365	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	21	ATF2(1), BCR(2), BLNK(4), ELK1(2), FOS(6), JUN(1), LYN(8), MAP2K1(5), MAP3K1(6), MAPK8IP3(9), PAPPA(13), RPS6KA1(10), RPS6KA3(4), SHC1(2), SOS1(9), SYK(8), VAV1(7), VAV2(4), VAV3(4)	23285378	105	88	105	26	25	14	29	15	22	0	0.108	1.000	1.000
366	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	22	ADCY1(21), AKT1(2), CAMK2A(2), CAMK2B(3), CAMK2D(3), CAMK2G(2), CREB1(1), GNAS(13), MAPK14(2), PIK3R1(9), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), PRKCA(7), RPS6KA1(10), RPS6KA5(5), SOS1(9)	19383426	105	87	104	27	21	23	30	14	17	0	0.1000	1.000	1.000
367	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	19	ADCY1(21), AKT1(2), ASAH1(1), GNAI1(2), GNB1(3), ITGAV(6), ITGB3(6), PDGFRA(13), PIK3R1(9), PLCB1(22), PRKCA(7), PTK2(8), SRC(1)	18404354	101	87	99	31	13	19	35	16	18	0	0.278	1.000	1.000
368	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(1), ACP2(2), ACP5(1), ACPP(2), ACPT(3), ALPI(3), ALPL(4), ALPP(5), ALPPL2(7), CYP19A1(3), CYP1A1(2), CYP1A2(5), CYP2A13(4), CYP2A6(2), CYP2A7(3), CYP2B6(5), CYP2C18(3), CYP2C19(6), CYP2C8(6), CYP2C9(6), CYP2D6(4), CYP2E1(6), CYP2F1(2), CYP2J2(7), CYP3A4(4), CYP3A5(1), CYP3A7(1), CYP4B1(3), CYP51A1(1), PON1(4)	22371140	106	87	106	42	16	17	40	17	15	1	0.777	1.000	1.000
369	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	AGXT(2), AGXT2(5), ALAS2(4), AMT(2), AOC2(6), AOC3(5), ATP6V0C(1), BHMT(1), CHDH(3), CHKB(1), CPT1B(4), CTH(3), DAO(1), DLD(1), DMGDH(6), GAMT(2), GATM(4), GCAT(5), GLDC(10), MAOA(1), MAOB(1), PLCB2(6), PLCG1(9), PLCG2(9), PSPH(2), SARDH(9), SARS(1), SHMT1(1), SHMT2(3), TARS(6)	31926425	114	87	114	48	29	20	36	19	10	0	0.787	1.000	1.000
370	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	31	AKT1(2), BAD(1), BCL2(1), BCL2L1(2), CBL(3), CFLAR(2), CRKL(3), FOS(6), IL2RA(2), IL2RB(3), IRS1(2), JAK1(10), JAK3(6), MYC(6), NMI(6), PIK3R1(9), PTPN6(3), RAF1(3), RPS6KB1(4), SHC1(2), SOCS1(1), SOCS3(1), SOS1(9), STAT5A(3), STAT5B(5), SYK(8)	25040678	103	87	101	30	13	29	28	15	18	0	0.0940	1.000	1.000
371	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(4), CS(3), DLAT(4), DLD(1), DLST(6), FH(3), IDH2(1), IDH3A(1), IDH3B(1), MDH1(1), MDH2(1), OGDH(10), PC(14), PDHA1(4), PDHA2(14), PDHB(1), PDHX(4), PDK1(3), PDK2(1), PDK3(3), PDK4(9), SDHA(6), SDHB(1), SDHC(1), SUCLA2(2), SUCLG1(1), SUCLG2(3)	21604202	103	87	102	29	13	24	35	17	14	0	0.185	1.000	1.000
372	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(3), AASDH(5), AASDHPPT(3), AASS(3), ACAT2(2), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), ATP6V0C(1), BBOX1(2), DLST(6), DOT1L(9), ECHS1(2), EHHADH(5), EHMT1(7), EHMT2(10), GCDH(2), HADHA(3), PLOD1(4), PLOD2(9), PLOD3(4), SDS(1), SHMT1(1), SHMT2(3), TMLHE(2)	28229761	111	87	111	49	20	19	27	23	22	0	0.894	1.000	1.000
373	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(6), ACACA(16), ACADL(4), ACADM(3), ACADSB(3), ACAT2(2), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH6A1(2), ALDH9A1(3), ECHS1(2), EHHADH(5), HADHA(3), LDHA(1), LDHB(1), LDHC(4), MLYCD(2), MUT(5), PCCA(9), PCCB(1), SDS(1), SUCLA2(2), SUCLG1(1), SUCLG2(3)	25226371	100	87	100	32	18	17	31	19	15	0	0.585	1.000	1.000
374	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(6), ACADL(4), ACADM(3), ACADSB(3), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), AOC2(6), AOC3(5), CNDP1(9), DPYD(16), DPYS(7), ECHS1(2), EHHADH(5), GAD1(4), GAD2(6), HADHA(3), MLYCD(2), SDS(1), SMS(3), UPB1(1)	22146251	110	86	110	33	14	30	34	22	10	0	0.248	1.000	1.000
375	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	30	DUSP1(2), MAP2K4(2), MAP2K7(2), MAPK10(4), MAPK11(3), MAPK12(3), MAPK13(3), MAPK14(2), MAPK8(4), MAPK8IP1(4), MAPK8IP2(2), MAPK8IP3(9), MAPK9(4), MAPKAPK5(2), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(1), NFKBIE(1), NFKBIL1(1), PIK3CD(8), PIK3R1(9), SYT1(9), TRAF2(2), TRAF3(6), TRAF5(1), TRAF6(3)	23536043	98	86	98	28	21	18	25	11	23	0	0.103	1.000	1.000
376	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	25	AKT1(2), AKT2(4), AKT3(6), BAD(1), BCL2(1), GSK3A(2), GSK3B(3), IL4R(8), IRS1(2), IRS2(6), JAK1(10), JAK3(6), MAP4K1(5), PDK1(3), PIK3CD(8), PIK3R1(9), PPP1R13B(2), RAF1(3), SHC1(2), SOCS1(1), SOS1(9), SOS2(11), STAT6(5)	25739652	109	86	109	33	18	22	31	23	15	0	0.230	1.000	1.000
377	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ADH1A(2), ADH1B(2), ADH4(2), ADH6(1), ADH7(2), ADHFE1(4), ALDH1A3(1), ALDH3A1(1), ALDH3B1(3), ALDH3B2(4), AOC2(6), AOC3(5), AOX1(11), COMT(1), DBH(8), DCT(3), DDC(7), FAH(2), GOT1(1), GOT2(2), GSTZ1(1), HGD(4), HPD(3), MAOA(1), MAOB(1), PNMT(1), TAT(2), TH(3), TPO(12), TYR(8)	24144687	104	86	103	40	17	25	31	12	19	0	0.541	1.000	1.000
378	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	15	ACTA1(4), ACTN1(4), ACTN2(10), CAPN1(3), CAPNS1(2), CAPNS2(2), ITGA1(4), ITGB1(15), ITGB3(6), PTK2(8), PXN(2), SPTAN1(23), SRC(1), TLN1(22)	21456063	106	85	105	24	17	17	40	19	13	0	0.0507	1.000	1.000
379	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	ERCC3(5), GTF2A2(1), GTF2B(1), GTF2E1(7), GTF2F2(2), GTF2H1(3), GTF2H4(3), ILK(4), MNAT1(1), POLR1A(9), POLR1B(3), POLR2A(12), POLR2B(9), POLR2C(1), POLR2E(1), POLR2F(3), POLR2G(4), POLR2H(1), POLR2I(1), POLR2J(2), POLR3B(4), POLR3D(2), POLR3E(5), POLR3H(1), TAF13(1), TAF5(7), TAF6(5), TAF7(2), TAF9(3), TBP(2)	26709019	105	83	105	37	8	23	26	22	26	0	0.687	1.000	1.000
380	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(2), GUSB(5), RPE(1), UGDH(3), UGP2(2), UGT1A1(5), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A9(1), UGT2A1(6), UGT2A3(6), UGT2B10(11), UGT2B11(9), UGT2B15(4), UGT2B17(4), UGT2B28(6), UGT2B4(13), UGT2B7(7), XYLB(3)	20821203	101	82	101	45	14	15	37	25	10	0	0.974	1.000	1.000
381	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	20	CHUK(6), CREBBP(37), DUSP1(2), IKBKB(11), IL1B(1), MAP2K3(5), MAP2K6(1), MAP3K7(8), MAPK11(3), MAPK14(2), NFKB1(5), NFKBIA(1), NR3C1(6), RELA(2), TGFBR1(2), TLR2(2)	18005239	94	82	92	26	12	16	29	16	20	1	0.273	1.000	1.000
382	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	28	ATF1(3), BAD(1), BRAF(10), CREB1(1), CREB5(7), DUSP4(1), DUSP6(5), DUSP9(1), EEF2K(5), EIF4E(1), MAP2K1(5), MAP2K2(6), MAP3K8(4), MKNK1(1), MKNK2(2), MOS(7), NFKB1(5), RPS6KA1(10), RPS6KA2(6), RPS6KA3(4), SHC1(2), SOS1(9), SOS2(11), TRAF3(6)	21970269	113	82	112	30	24	21	36	20	12	0	0.129	1.000	1.000
383	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	39	APAF1(12), BAK1(1), BCL2(1), BCL2L1(2), BID(3), BIRC2(3), BIRC3(2), CASP2(3), CASP3(2), CASP6(5), CASP7(3), CASP9(1), FADD(3), FAS(5), FASLG(1), GZMB(2), JUN(1), MAP2K4(2), MAP3K1(6), MAPK10(4), MCL1(3), MDM2(3), MYC(6), NFKB1(5), NFKBIA(1), PARP1(5), PRF1(5), RELA(2), RIPK1(2), TNFRSF1A(2), TNFRSF1B(2), TNFSF10(1), TRADD(1), TRAF2(2)	27090128	102	81	100	27	16	27	27	14	18	0	0.0979	1.000	1.000
384	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	AGXT(2), AGXT2(5), AKR1B10(4), ALAS2(4), AMT(2), AOC2(6), AOC3(5), BHMT(1), CHDH(3), CHKB(1), CTH(3), DAO(1), DLD(1), DMGDH(6), GAMT(2), GATM(4), GCAT(5), GLDC(10), HSD3B7(2), MAOA(1), MAOB(1), PHGDH(1), PIPOX(2), PSAT1(1), PSPH(2), RDH11(2), RDH12(4), SARDH(9), SARS(1), SDS(1), SHMT1(1), SHMT2(3), TARS(6), TARS2(4)	32447784	106	81	106	44	27	20	35	15	8	1	0.727	1.000	1.000
385	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(4), ALG10(7), ALG10B(3), ALG11(3), ALG12(5), ALG13(4), ALG2(2), ALG3(1), ALG5(2), ALG6(4), ALG8(1), B4GALT1(1), B4GALT2(5), B4GALT3(1), DDOST(1), DHDDS(2), DOLPP1(2), DPAGT1(1), DPM1(2), FUT8(2), GANAB(4), MAN1A1(2), MAN1A2(1), MAN1B1(4), MAN1C1(3), MAN2A1(5), MGAT1(4), MGAT2(3), MGAT3(4), MGAT4A(2), MGAT4B(3), MGAT5(4), MGAT5B(5), RFT1(1), RPN1(2), RPN2(6), ST6GAL1(4), STT3B(2)	32298969	112	81	112	43	15	24	35	17	21	0	0.766	1.000	1.000
386	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B3GNT6(2), B4GALT5(3), C1GALT1(4), C1GALT1C1(2), GALNT1(1), GALNT10(5), GALNT11(4), GALNT12(4), GALNT13(9), GALNT14(6), GALNT2(7), GALNT3(6), GALNT4(3), GALNT5(4), GALNT6(4), GALNT7(3), GALNT8(6), GALNT9(1), GALNTL5(5), GCNT1(1), GCNT3(1), GCNT4(4), OGT(4), ST3GAL1(2), ST3GAL2(1), ST6GALNAC1(1), WBSCR17(10)	24611456	103	81	103	36	17	28	27	15	15	1	0.519	1.000	1.000
387	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM1(1), CALM2(2), CALM3(2), CHUK(6), EGR2(5), MAP3K1(6), MYC(6), NFATC1(7), NFATC2(15), NFKB1(5), NFKBIA(1), PLCG1(9), PPP3CA(2), PPP3CB(1), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), RELA(2), SYT1(9), VIP(1), VIPR2(5)	21327734	101	81	99	37	21	21	30	16	13	0	0.455	1.000	1.000
388	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	ARSB(2), FUCA2(1), GALNS(1), GBA(2), GLB1(5), GNS(3), GUSB(5), HEXA(4), HGSNAT(2), HPSE(4), HPSE2(3), HYAL1(2), HYAL2(2), IDS(7), IDUA(6), LCT(17), MAN2B1(4), MAN2B2(2), MAN2C1(4), MANBA(4), NAGLU(4), NEU1(2), NEU2(2), NEU3(1), NEU4(2), SPAM1(2)	26245996	93	80	93	42	23	17	18	18	17	0	0.821	1.000	1.000
389	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(2), CAMK2B(3), CAMK2D(3), CAMK2G(2), DAG1(5), ITPKB(5), ITPR1(15), ITPR2(25), ITPR3(10), NFAT5(12), PDE6A(3), PDE6B(2), PDE6C(3), SLC6A13(4), TF(5)	27144403	99	80	99	39	10	35	25	16	13	0	0.560	1.000	1.000
390	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	15	ADAM12(6), AGT(4), AGTR2(2), EDN1(1), EDNRA(2), EDNRB(7), EGF(8), EGFR(19), FOS(6), JUN(1), MYC(6), NFKB1(5), PLCG1(9), PRKCA(7), RELA(2)	15341627	85	79	83	26	12	19	31	14	8	1	0.282	1.000	1.000
391	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(4), ACO1(8), ACO2(4), CLYBL(1), CS(3), DLD(1), DLST(6), FH(3), IDH1(4), IDH2(1), IDH3A(1), IDH3B(1), MDH1(1), MDH2(1), OGDH(10), OGDHL(11), PC(14), PCK1(2), PCK2(4), SDHA(6), SDHB(1), SDHC(1), SUCLA2(2), SUCLG1(1), SUCLG2(3)	22737982	94	79	93	36	19	19	28	15	13	0	0.578	1.000	1.000
392	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(6), ACADM(3), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), ALDH9A1(3), AOC2(6), AOC3(5), CNDP1(9), DPYD(16), DPYS(7), ECHS1(2), EHHADH(5), GAD1(4), GAD2(6), HADHA(3), HIBCH(2), MLYCD(2), SMS(3), UPB1(1)	20581105	95	79	95	30	13	30	27	19	6	0	0.259	1.000	1.000
393	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(15), APOA4(4), APOC1(1), CETP(2), CYP7A1(6), DGAT1(1), HMGCR(5), LCAT(2), LDLR(4), LIPC(5), LPL(4), LRP1(33), SCARB1(1), SOAT1(5)	20899980	88	79	87	25	12	21	26	16	13	0	0.178	1.000	1.000
394	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	19	AKT1(2), APAF1(12), ATM(16), BAD(1), BCL2(1), BCL2L1(2), BID(3), CASP3(2), CASP6(5), CASP7(3), CASP9(1), EIF2S1(2), PRKCA(7), PTK2(8), PXN(2), STAT1(8), TLN1(22)	20255787	97	78	97	26	10	28	22	19	18	0	0.186	1.000	1.000
395	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	22	GH1(4), GHR(9), INSR(3), IRS1(2), JAK2(5), MAP2K1(5), PIK3R1(9), PLCG1(9), PRKCA(7), PTPN6(3), RAF1(3), RPS6KA1(10), SHC1(2), SLC2A4(3), SOCS1(1), SOS1(9), SRF(1), STAT5A(3), STAT5B(5)	22702678	93	78	93	24	14	23	33	11	12	0	0.0743	1.000	1.000
396	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	37	ANAPC1(8), ANAPC4(2), ANAPC5(1), ANAPC7(1), BTRC(1), CDC16(2), CDC20(1), CDC23(4), CDC26(1), CDC27(9), CUL1(11), CUL2(3), FBXW11(3), FZR1(4), ITCH(7), RBX1(3), SKP1(1), SKP2(4), SMURF1(4), SMURF2(6), TCEB1(2), UBA1(3), UBE2D2(1), UBE2D4(1), WWP1(7), WWP2(7)	28084918	97	78	96	36	12	28	21	21	15	0	0.747	1.000	1.000
397	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(6), IKBKB(11), IL1A(1), IL1B(1), IL1R1(4), IL1RAP(6), IL6(2), IRAK1(3), IRAK2(2), IRAK3(9), JUN(1), MAP2K3(5), MAP2K6(1), MAP3K1(6), MAP3K7(8), MAPK14(2), MAPK8(4), NFKB1(5), NFKBIA(1), RELA(2), TGFB1(1), TGFB2(4), TGFB3(1), TOLLIP(2), TRAF6(3)	22681088	91	78	90	29	17	17	26	12	19	0	0.427	1.000	1.000
398	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	31	APAF1(12), BCL2(1), BID(3), BIRC2(3), BIRC3(2), CASP10(2), CASP3(2), CASP6(5), CASP7(3), CASP9(1), CFLAR(2), CHUK(6), FADD(3), GAS2(3), LMNA(1), NFKB1(5), NFKBIA(1), RELA(2), RIPK1(2), SPTAN1(23), TNFRSF10A(3), TNFRSF10B(1), TNFRSF25(2), TNFSF10(1), TRADD(1), TRAF2(2)	24634274	92	77	92	23	17	25	21	11	18	0	0.0453	1.000	1.000
399	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(6), ALDH5A1(1), CAD(5), CPS1(14), EPRS(5), GAD1(4), GAD2(6), GCLC(4), GCLM(1), GFPT1(3), GLS(1), GLS2(2), GLUD1(3), GLUL(3), GMPS(7), GOT1(1), GOT2(2), GPT(1), GPT2(4), GSS(3), NADSYN1(3), PPAT(3), QARS(5)	25303711	87	76	87	43	13	20	22	17	15	0	0.966	1.000	1.000
400	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	14	BCL2(1), CREBBP(37), FYN(4), IL7(2), IL7R(6), JAK1(10), JAK3(6), LCK(5), NMI(6), PIK3R1(9), PTK2B(4), STAT5A(3), STAT5B(5)	15872900	98	76	97	29	9	20	25	21	22	1	0.163	1.000	1.000
401	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(5), GTF2A1(4), GTF2B(1), GTF2E1(7), GTF2F1(4), HDAC3(4), NCOA1(7), NCOA2(9), NCOA3(8), NCOR2(22), POLR2A(12), RARA(5), RXRA(4), TBP(2)	19027728	94	76	94	23	13	22	24	24	11	0	0.0553	1.000	1.000
402	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(3), AKR1D1(3), ARSB(2), ARSD(4), ARSE(3), CYP11B1(6), CYP11B2(4), HSD11B2(3), HSD17B2(2), HSD17B3(2), HSD17B8(3), HSD3B1(4), HSD3B2(4), STS(4), SULT1E1(5), SULT2A1(2), UGT1A1(5), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A9(1), UGT2B15(4), UGT2B4(13)	20807898	90	75	90	36	19	15	27	20	9	0	0.742	1.000	1.000
403	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	21	ADCY1(21), AKT1(2), BAD(1), BCL2(1), BCL2L1(2), CSF2RB(7), IGF1(1), IGF1R(11), IL3(1), IL3RA(5), KIT(12), KITLG(1), PIK3R1(9), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), YWHAH(2)	15051887	92	75	91	28	13	22	23	16	18	0	0.150	1.000	1.000
404	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOA(1), ALDOB(5), ALDOC(4), FBP2(1), G6PD(4), GPI(3), H6PD(2), PFKL(6), PFKM(6), PFKP(5), PGD(2), PGM1(5), PGM3(1), PRPS1(3), PRPS1L1(5), PRPS2(2), RBKS(3), RPE(1), RPIA(3), TALDO1(5), TKT(3), TKTL1(6), TKTL2(9)	18495542	85	75	85	32	14	16	26	18	11	0	0.546	1.000	1.000
405	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ARG1(1), ARG2(1), ASL(2), ASS1(2), CKB(4), CKM(3), CKMT1B(2), CPS1(14), DAO(1), EPRS(5), GAMT(2), GATM(4), GLUD1(3), GLUD2(10), GOT1(1), GOT2(2), LAP3(2), NOS1(9), NOS3(4), OAT(1), OTC(2), P4HA1(4), P4HA2(3), P4HA3(1), PARS2(5), PRODH(1), PYCR1(1), RARS(1), RARS2(3)	27378586	94	75	94	33	19	16	21	24	14	0	0.568	1.000	1.000
406	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSA(1), ARSD(4), ARSE(3), ASAH1(1), B4GALT6(2), CERK(3), DEGS1(1), DEGS2(1), ENPP7(5), GAL3ST1(3), GALC(2), GBA(2), GLA(2), GLB1(5), LCT(17), NEU1(2), NEU2(2), NEU3(1), NEU4(2), PPAP2A(1), PPAP2B(1), SGMS1(2), SGMS2(1), SGPP1(5), SGPP2(2), SMPD3(2), SMPD4(5), SPHK2(3), SPTLC1(5), SPTLC2(3), UGCG(1)	27302689	90	75	90	39	20	21	24	13	12	0	0.589	1.000	1.000
407	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	ALOX12(3), ALOX5(5), CBR3(1), CYP4F2(6), CYP4F3(2), EPX(9), GGT1(4), LTA4H(2), MPO(7), PLA2G1B(2), PLA2G2A(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PRDX2(2), PRDX6(1), PTGDS(2), PTGES2(1), PTGIS(7), PTGS1(7), PTGS2(3), TBXAS1(5), TPO(12)	21298308	92	75	91	51	21	17	26	11	17	0	0.973	1.000	1.000
408	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	21	AKT1(2), AP2A1(4), AP2M1(3), ARF1(1), BAD(1), BTK(8), EEA1(11), GRASP(1), GSK3A(2), GSK3B(3), LYN(8), PDPK1(4), PFKL(6), PFKM(6), PFKP(5), PLCG1(9), PRKCE(3), PRKCZ(3), RAB5A(3), RPS6KB1(4), VAV2(4)	18760404	91	75	90	28	12	17	29	14	18	1	0.329	1.000	1.000
409	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	15	CBL(3), EGF(8), EGFR(19), MAP2K1(5), PTPRB(22), RAF1(3), SHC1(2), SOS1(9), SPRY1(3), SPRY2(4), SPRY3(3), SPRY4(2), SRC(1)	16621013	84	75	84	27	12	12	29	19	11	1	0.565	1.000	1.000
410	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(2), ABAT(6), ADSL(4), ADSS(4), AGXT(2), AGXT2(5), ASL(2), ASNS(5), ASPA(4), CAD(5), CRAT(6), DARS(5), DDO(2), GAD1(4), GAD2(6), GOT1(1), GOT2(2), GPT(1), GPT2(4), NARS(2), PC(14)	19850511	86	74	86	27	15	17	28	14	12	0	0.296	1.000	1.000
411	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	11	CREBBP(37), DAXX(6), PAX3(6), PML(1), RARA(5), RB1(17), SIRT1(3), SP100(8), TNFRSF1A(2), TNFRSF1B(2)	13562238	87	74	86	28	7	19	25	10	25	1	0.517	1.000	1.000
412	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	25	BCAR1(3), CALM1(1), CALM2(2), CALM3(2), CRKL(3), JUN(1), MAP2K1(5), MAP2K2(6), MAP2K3(5), MAP2K4(2), MAP3K1(6), MAPK14(2), MAPK8(4), PAK1(3), PLCG1(9), PRKCA(7), PTK2B(4), RAF1(3), SHC1(2), SOS1(9), SRC(1), SYT1(9)	20558341	89	74	89	30	20	13	32	13	11	0	0.547	1.000	1.000
413	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	21	BTK(8), DLG4(3), EPHB2(3), F2(3), F2RL1(1), F2RL2(2), F2RL3(3), JUN(1), MAP2K5(3), MAPK7(6), MAPK8(4), MYEF2(8), PLD1(15), PLD2(1), PLD3(2), PTK2(8), RAF1(3), RASAL1(5), SRC(1), TEC(2), VAV1(7)	20447514	89	74	89	26	6	19	26	16	21	1	0.282	1.000	1.000
414	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	17	CSF1(2), CSF1R(2), DDX20(4), E2F4(3), ETS1(5), ETS2(7), FOS(6), HDAC2(3), HDAC5(3), JUN(1), NCOR2(22), RBL1(12), RBL2(6), SIN3A(7), SIN3B(11)	19504894	94	73	94	28	16	28	23	14	13	0	0.0990	1.000	1.000
415	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(16), AP2A1(4), AP2M1(3), BIN1(4), CALM1(1), CALM2(2), CALM3(2), DNM1(2), EPN1(6), EPS15(7), NME2(1), PICALM(4), PPP3CA(2), PPP3CB(1), SYNJ1(10), SYNJ2(8), SYT1(9)	16542029	82	73	82	34	10	16	30	14	12	0	0.883	1.000	1.000
416	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA2(1), ACAD8(4), ACAD9(2), ADH1A(2), ADH1B(2), ADH4(2), ADH5(3), ADH6(1), ADH7(2), ADHFE1(4), AKR1B10(4), AKR1C4(3), AKR1D1(3), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), ALDH9A1(3), BAAT(2), CEL(2), CYP27A1(2), CYP7A1(6), HADHB(4), HSD3B7(2), LIPA(3), RDH11(2), RDH12(4), SLC27A5(4), SOAT1(5), SOAT2(2)	24100412	86	72	86	39	18	18	25	17	8	0	0.884	1.000	1.000
417	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	14	ATN1(14), BAIAP2(2), CASP1(2), CASP3(2), CASP7(3), GAPDH(2), INSR(3), ITCH(7), MAGI1(13), MAGI2(20), RERE(7), WWP1(7), WWP2(7)	17394674	89	71	89	37	13	25	22	16	13	0	0.845	1.000	1.000
418	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	CHUK(6), FADD(3), IKBKB(11), IL1A(1), IL1R1(4), IRAK1(3), MAP3K1(6), MAP3K7(8), NFKB1(5), NFKBIA(1), RELA(2), RIPK1(2), TLR4(17), TNFAIP3(6), TNFRSF1A(2), TNFRSF1B(2), TRADD(1), TRAF6(3)	18637126	83	71	82	30	14	17	26	13	13	0	0.583	1.000	1.000
419	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	11	ACE2(4), AGT(4), AGTR2(2), CMA1(5), COL4A1(10), COL4A2(9), COL4A3(18), COL4A4(14), COL4A5(14), COL4A6(4), REN(3)	18638104	87	70	86	37	10	25	28	13	11	0	0.943	1.000	1.000
420	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(4), ABAT(6), ACADS(2), ACAT2(2), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH5A1(1), ALDH9A1(3), ECHS1(2), EHHADH(5), GAD1(4), GAD2(6), HADHA(3), HMGCL(1), L2HGDH(4), OXCT1(1), PDHA1(4), PDHA2(14), PDHB(1), SDHB(1), SDS(1)	19655941	86	70	86	33	11	26	24	11	14	0	0.693	1.000	1.000
421	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(2), ALDOA(1), ALDOB(5), ALDOC(4), FBP2(1), FPGT(6), GCK(4), GMDS(4), GMPPA(1), HK1(4), HK2(6), HK3(8), KHK(3), MPI(4), PFKFB1(3), PFKFB3(2), PFKFB4(1), PFKM(6), PFKP(5), PMM2(2), SORD(2), TPI1(4)	18170948	78	70	78	21	14	21	19	13	11	0	0.0543	1.000	1.000
422	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ACY1(3), AGMAT(2), ALDH18A1(2), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), ALDH9A1(3), AMD1(4), AOC2(6), AOC3(5), ARG1(1), ARG2(1), ASL(2), ASS1(2), CPS1(14), GATM(4), MAOA(1), MAOB(1), NAGS(3), ODC1(3), OTC(2), SAT1(4), SAT2(2), SMS(3)	22414719	80	70	80	27	19	22	20	11	8	0	0.304	1.000	1.000
423	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(2), ASNS(5), ASRGL1(1), CA1(1), CA12(2), CA14(2), CA2(1), CA3(5), CA4(5), CA5A(1), CA5B(1), CA6(3), CA7(1), CA8(5), CA9(1), CPS1(14), CTH(3), GLS(1), GLS2(2), GLUD1(3), GLUD2(10), GLUL(3), HAL(6)	16185960	78	70	78	33	16	14	23	16	9	0	0.873	1.000	1.000
424	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	21	CSNK2A1(7), ELK1(2), FOS(6), IL2(2), IL2RA(2), IL2RB(3), JAK1(10), JAK3(6), JUN(1), LCK(5), MAP2K1(5), MAPK8(4), RAF1(3), SHC1(2), SOS1(9), STAT5A(3), STAT5B(5), SYK(8)	17423023	83	70	83	23	10	18	28	11	16	0	0.102	1.000	1.000
425	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA1(2), ANXA3(2), ANXA4(3), ANXA6(6), CYP11A1(3), EDN1(1), EDNRA(2), EDNRB(7), HPGD(1), HSD11B2(3), PLA2G4A(3), PRL(3), PTGDR(3), PTGDS(2), PTGER2(5), PTGER4(8), PTGFR(2), PTGIR(3), PTGIS(7), PTGS1(7), PTGS2(3), TBXAS1(5)	15721510	81	70	79	23	15	12	17	13	23	1	0.218	1.000	1.000
426	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH3B1(3), ALDH3B2(4), ALDH9A1(3), AOC2(6), AOC3(5), ASPA(4), CNDP1(9), DDC(7), HAL(6), HARS(1), HDC(4), HNMT(1), MAOA(1), MAOB(1), PRPS1(3), PRPS2(2)	18583750	81	69	81	25	13	17	29	12	10	0	0.255	1.000	1.000
427	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(4), ALOX5(5), CYP1A2(5), CYP2C18(3), CYP2C19(6), CYP2C8(6), CYP2C9(6), CYP2E1(6), CYP2J2(7), CYP3A4(4), CYP3A43(3), CYP3A5(1), CYP3A7(1), HSD3B7(2), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), RDH11(2), RDH12(4)	18211464	82	69	82	33	11	15	36	10	9	1	0.706	1.000	1.000
428	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	16	ACE(8), ACE2(4), AGT(4), AGTR2(2), CMA1(5), CPA3(7), CTSA(1), CTSG(1), ENPEP(13), LNPEP(5), MAS1(2), MME(16), NLN(10), REN(3), THOP1(1)	15569629	82	69	82	30	11	13	30	15	13	0	0.633	1.000	1.000
429	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(10), ARHGEF1(8), GNA12(1), GNA13(2), GNB1(3), MYLK(8), PLCB1(22), PPP1R12B(4), PRKCA(7), ROCK1(19)	15753904	84	69	83	29	13	16	29	15	11	0	0.657	1.000	1.000
430	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	20	BCAR1(3), CRK(2), CXCL12(3), CXCR4(2), GNAI1(2), GNB1(3), MAP2K1(5), NFKB1(5), PIK3C2G(11), PIK3R1(9), PLCG1(9), PRKCA(7), PTK2(8), PTK2B(4), PXN(2), RAF1(3), RELA(2)	18588908	80	68	79	29	14	10	24	15	17	0	0.801	1.000	1.000
431	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	19	AKT1(2), EIF4A1(3), EIF4A2(2), EIF4E(1), EIF4EBP1(1), EIF4G1(20), EIF4G2(8), EIF4G3(8), GHR(9), IRS1(2), MAPK14(2), MKNK1(1), PABPC1(1), PDK2(1), PDPK1(4), PIK3R1(9), PRKCA(7), RPS6KB1(4)	18685069	85	68	84	26	4	23	22	12	24	0	0.541	1.000	1.000
432	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	20	AKT1(2), BCL2(1), BCR(2), CRKL(3), FOS(6), JAK2(5), JUN(1), MAP2K1(5), MAP2K4(2), MAP3K1(6), MAPK8(4), MYC(6), PIK3R1(9), RAF1(3), SOS1(9), STAT1(8), STAT5A(3), STAT5B(5)	19458658	80	68	78	26	9	23	25	8	15	0	0.395	1.000	1.000
433	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(3), CHIA(5), CHIT1(4), CTBS(2), CYB5R1(1), CYB5R3(6), GFPT1(3), GFPT2(5), GNE(2), GNPDA1(2), GNPNAT1(1), HEXA(4), HK1(4), HK2(6), HK3(8), LHPP(1), MTMR1(2), MTMR2(3), MTMR6(3), NANS(2), PGM3(1), PHPT1(1), RENBP(5), UAP1(5)	21848261	79	68	79	24	19	17	20	9	14	0	0.203	1.000	1.000
434	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(10), COL4A2(9), COL4A3(18), COL4A4(14), COL4A5(14), COL4A6(4), P4HB(1), SLC23A1(3), SLC23A2(6), SLC2A1(4), SLC2A3(2)	19044130	85	68	84	40	10	26	22	15	12	0	0.966	1.000	1.000
435	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(2), CARS(4), DARS(5), EPRS(5), FARS2(5), HARS(1), IARS(11), KARS(4), LARS(5), LARS2(2), MARS(2), MARS2(5), NARS(2), QARS(5), RARS(1), SARS(1), TARS(6), WARS(2), WARS2(8), YARS(6)	24355967	82	67	82	19	6	15	32	19	10	0	0.150	1.000	1.000
436	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	18	ABL1(8), ATM(16), BRCA1(12), CHEK1(1), CHEK2(4), GADD45A(1), JUN(1), MAPK8(4), MDM2(3), MRE11A(3), NFKB1(5), NFKBIA(1), RAD50(10), RAD51(1), RBBP8(5), RELA(2)	22112705	77	66	76	24	6	19	25	13	14	0	0.709	1.000	1.000
437	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5(3), CDK5R1(1), CSNK1D(1), DRD1(2), DRD2(4), GRM1(28), PLCB1(22), PPP1CA(1), PPP3CA(2), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3)	12164878	80	66	78	29	14	20	21	18	7	0	0.361	1.000	1.000
438	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	19	AKT1(2), EIF4A1(3), EIF4A2(2), EIF4B(7), EIF4E(1), EIF4EBP1(1), EIF4G1(20), EIF4G2(8), EIF4G3(8), MKNK1(1), PDK2(1), PDPK1(4), PIK3R1(9), RPS6KB1(4), TSC1(3), TSC2(7)	18801269	81	65	80	22	7	20	22	9	23	0	0.357	1.000	1.000
439	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	17	CABIN1(14), CALM1(1), CALM2(2), CALM3(2), CAPN2(5), CAPNS1(2), CAPNS2(2), HDAC1(1), HDAC2(3), MEF2D(1), NFATC1(7), NFATC2(15), PPP3CA(2), PPP3CB(1), PRKCA(7), SYT1(9)	14846695	74	64	73	26	11	18	20	17	8	0	0.365	1.000	1.000
440	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(3), ICAM1(6), ITGA4(14), ITGAL(8), ITGAM(8), ITGB1(15), ITGB2(3), SELE(7), SELL(2), SELP(16)	12136275	82	64	81	33	8	19	21	14	20	0	0.738	1.000	1.000
441	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCL3(1), CCL4(1), CCR1(1), CCR2(4), CCR3(5), CCR4(4), CCR7(2), CD28(3), CD4(1), CXCR3(1), CXCR4(2), IFNG(2), IFNGR1(4), IFNGR2(4), IL12A(1), IL12B(3), IL12RB1(3), IL12RB2(10), IL18R1(3), IL2(2), IL4(1), IL4R(8), IL5(2), TGFB1(1), TGFB2(4), TGFB3(1)	15237567	74	63	73	25	11	11	22	14	16	0	0.390	1.000	1.000
442	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5(3), CDK5R1(1), DAB1(9), FYN(4), LRP8(5), RELN(50), VLDLR(5)	10663460	77	63	77	26	13	15	20	15	14	0	0.517	1.000	1.000
443	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	ATF1(3), CASP2(3), CHUK(6), CRADD(2), IKBKB(11), JUN(1), LTA(4), MAP2K3(5), MAP2K4(2), MAP2K6(1), MAP3K1(6), MAP4K2(2), MAPK14(2), MAPK8(4), NFKB1(5), NFKBIA(1), RELA(2), RIPK1(2), TANK(2), TNFRSF1A(2), TRADD(1), TRAF2(2)	18467180	69	63	69	25	13	12	21	9	14	0	0.630	1.000	1.000
444	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	CALM1(1), CALM2(2), CALM3(2), MARCKS(1), NFATC1(7), NFATC2(15), NFATC3(5), NFATC4(3), PLCG1(9), PPP3CA(2), PPP3CB(1), PRKCA(7), SP1(3), SP3(3), SYT1(9)	16014044	70	62	70	26	12	14	22	15	7	0	0.564	1.000	1.000
445	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(4), ACTN2(10), BCAR1(3), CSK(1), CTNNA1(8), CTNNA2(31), CTNNB1(6), PTK2(8), PXN(2), SRC(1), VCL(5)	14654852	79	62	77	36	10	15	30	13	10	1	0.955	1.000	1.000
446	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(2), ASNS(5), CA1(1), CA12(2), CA14(2), CA2(1), CA3(5), CA4(5), CA5A(1), CA5B(1), CA6(3), CA7(1), CA8(5), CA9(1), CPS1(14), CTH(3), GLS(1), GLS2(2), GLUD1(3), GLUL(3), HAL(6)	14478878	67	62	67	28	12	13	20	15	7	0	0.851	1.000	1.000
447	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ALDH1A3(1), ALDH3A1(1), ALDH3B1(3), ALDH3B2(4), AOC2(6), AOC3(5), DDC(7), EPX(9), ESCO1(4), ESCO2(3), GOT1(1), GOT2(2), HPD(3), MAOA(1), MAOB(1), MPO(7), PRDX6(1), SH3GLB1(1), TAT(2), TPO(12)	26072658	74	61	73	37	16	16	24	7	11	0	0.938	1.000	1.000
448	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(1), ALDOB(5), ALDOC(4), FBP2(1), G6PD(4), GPI(3), H6PD(2), PFKM(6), PFKP(5), PGD(2), PGM1(5), PGM3(1), PRPS1(3), PRPS1L1(5), PRPS2(2), RBKS(3), RPE(1), RPIA(3), TAL1(3), TALDO1(5), TKT(3)	15578679	67	61	67	26	11	13	19	15	9	0	0.537	1.000	1.000
449	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(2), BLVRA(3), CP(7), CPOX(1), EPRS(5), FECH(1), GUSB(5), HCCS(2), HMOX1(1), HMOX2(1), PPOX(1), UGT1A1(5), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A9(1), UGT2B15(4), UGT2B4(13), UROD(1), UROS(3)	20909278	69	61	69	40	8	12	24	16	9	0	0.998	1.000	1.000
450	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	17	DNAJA3(3), IFNG(2), IFNGR1(4), IFNGR2(4), IKBKB(11), JAK2(5), LIN7A(4), NFKB1(5), NFKBIA(1), RB1(17), RELA(2), TNFRSF1A(2), TNFRSF1B(2), USH1C(3), WT1(3)	13254616	68	61	67	23	5	11	22	8	22	0	0.572	1.000	1.000
451	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(2), GALNS(1), GLB1(5), GNS(3), GUSB(5), HEXA(4), HGSNAT(2), HPSE(4), HPSE2(3), HYAL1(2), HYAL2(2), IDS(7), IDUA(6), LCT(17), NAGLU(4), SPAM1(2)	15572237	69	60	69	29	13	14	13	17	12	0	0.757	1.000	1.000
452	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(3), B4GALNT1(3), GLB1(5), HEXA(4), LCT(17), SLC33A1(2), ST3GAL1(2), ST3GAL2(1), ST3GAL5(5), ST6GALNAC3(8), ST6GALNAC5(4), ST6GALNAC6(4), ST8SIA1(3), ST8SIA5(7)	12538130	68	60	68	21	15	14	17	12	10	0	0.186	1.000	1.000
453	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(11), BST1(2), CD38(5), ENPP1(10), ENPP3(8), NADK(2), NADSYN1(3), NMNAT1(4), NMNAT2(1), NNMT(3), NNT(5), NT5C1A(2), NT5C1B(7), NT5C2(2), NT5E(1), NUDT12(5), QPRT(1)	16425488	72	60	72	35	9	9	25	18	11	0	0.974	1.000	1.000
454	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	14	AKT1(2), CREB1(1), MAP2K1(5), MAP2K2(6), MAP2K3(5), MAP2K6(1), MAP3K1(6), MAPK14(2), NFKB1(5), PIK3R1(9), RB1(17), RELA(2), SP1(3)	12607665	64	59	64	24	10	6	17	5	26	0	0.926	1.000	1.000
455	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP1(1), ACP2(2), ACP5(1), ACP6(5), ACPP(2), ACPT(3), ALPI(3), ALPL(4), ALPP(5), ALPPL2(7), CMBL(2), CYP3A4(4), CYP3A43(3), CYP3A5(1), CYP3A7(1), DHRS1(2), DHRS2(4), DHRS3(1), DHRS7(1), PON1(4), PON2(2), PON3(8)	13740367	66	59	65	29	12	9	22	9	14	0	0.882	1.000	1.000
456	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(1), CARM1(5), CTH(3), GGT1(4), HEMK1(1), LCMT1(2), LCMT2(6), MARS(2), MARS2(5), MAT1A(1), METTL2B(3), METTL6(2), PAPSS1(6), PAPSS2(6), PRMT2(2), PRMT3(6), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(6), SCLY(1), SEPHS1(2), SEPHS2(3)	18983679	75	59	75	22	18	20	19	11	7	0	0.117	1.000	1.000
457	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(3), EXT2(5), EXTL1(3), EXTL2(3), EXTL3(2), GLCE(1), HS2ST1(5), HS3ST2(2), HS3ST3A1(3), HS3ST3B1(1), HS3ST5(6), HS6ST1(3), HS6ST2(1), HS6ST3(1), NDST1(1), NDST2(2), NDST3(7), NDST4(15)	15843136	64	59	64	30	13	11	24	9	7	0	0.911	1.000	1.000
458	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(21), GNAS(13), PLCE1(22), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), RAP2B(2)	11271304	74	59	73	23	19	14	23	8	10	0	0.301	1.000	1.000
459	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(21), GNAS(13), GNB1(3), PRKAA1(4), PRKAA2(5), PRKAB1(4), PRKAB2(1), PRKACB(3), PRKACG(2), PRKAG2(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3)	11690791	69	58	68	23	19	11	20	10	9	0	0.544	1.000	1.000
460	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(8), IL13(1), IL4(1), IL5(2), JUNB(2), MAF(1), MAP2K3(5), MAPK14(2), NFATC1(7), NFATC2(15), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3)	9272919	60	58	60	26	16	12	13	8	11	0	0.485	1.000	1.000
461	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOA(1), ALDOB(5), ALDOC(4), FBP2(1), GOT1(1), GOT2(2), GPT(1), GPT2(4), MDH1(1), MDH2(1), ME1(2), ME3(7), PGK1(2), PGK2(5), PKLR(3), RPE(1), RPIA(3), TKT(3), TKTL1(6), TKTL2(9), TPI1(4)	15396034	66	58	66	23	10	14	24	11	7	0	0.499	1.000	1.000
462	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ALDH1A3(1), ALDH3A1(1), ALDH3B1(3), ALDH3B2(4), AOC2(6), AOC3(5), DDC(7), EPX(9), GOT1(1), GOT2(2), HPD(3), MAOA(1), MAOB(1), MPO(7), PRDX2(2), PRDX6(1), TAT(2), TPO(12)	16733655	68	58	67	33	16	15	22	7	8	0	0.826	1.000	1.000
463	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(6), DUSP1(2), IKBKAP(6), IKBKB(11), LTA(4), MAP3K1(6), NFKB1(5), NFKBIA(1), RELA(2), RIPK1(2), TANK(2), TNFAIP3(6), TNFRSF1B(2), TRAF2(2), TRAF3(6)	17148266	63	58	63	21	11	14	17	7	14	0	0.396	1.000	1.000
464	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	AANAT(1), ACHE(2), CHAT(9), COMT(1), DBH(8), DDC(7), GAD1(4), GAD2(6), HDC(4), MAOA(1), PAH(7), PNMT(1), SLC18A3(6), TH(3), TPH1(3)	11006571	63	57	63	28	9	13	22	6	13	0	0.768	1.000	1.000
465	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	21	CCNA1(7), CCNB1(2), CCND1(3), CCND2(2), CCNE1(4), CDC25A(3), CDK4(5), CDK6(1), CDKN1B(2), CDKN2C(1), CDKN2D(1), RB1(17), RBL1(12), TFDP1(2)	11774141	62	57	62	18	4	13	12	11	22	0	0.388	1.000	1.000
466	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(21), CFTR(13), GNAS(13), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3), SLC9A3R1(1)	9990067	64	57	63	20	17	13	18	9	7	0	0.323	1.000	1.000
467	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(1), POLD1(11), POLD2(1), POLE(11), POLG(8), POLL(5), POLQ(23)	12757965	60	57	60	19	11	11	15	7	16	0	0.373	1.000	1.000
468	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	18	ABCB1(19), AKT1(2), ATM(16), CPB2(4), CSNK1A1(1), CSNK1D(1), FHL2(1), GADD45A(1), HIC1(1), HIF1A(4), IGFBP3(1), MAPK8(4), MDM2(3), NFKBIB(1), NQO1(3)	15231406	62	57	62	24	9	11	19	10	13	0	0.867	1.000	1.000
469	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(32), MAP2(19), PPP1CA(1), PRKACB(3), PRKACG(2), PRKAR2B(3), PRKCE(3)	13814838	63	56	62	19	3	7	24	12	17	0	0.787	1.000	1.000
470	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(4), F13A1(9), F2(3), F2R(4), FGA(12), FGB(4), FGG(6), PLAT(4), PLG(13), SERPINB2(2), SERPINE1(7)	10199988	68	56	68	22	7	16	20	8	17	0	0.516	1.000	1.000
471	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(2), AGPAT2(3), AGPAT3(3), AGPAT4(2), AGPAT6(2), AGPS(5), CHPT1(2), ENPP2(10), ENPP6(5), PAFAH1B1(2), PAFAH1B3(1), PAFAH2(1), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3), PLD1(15), PLD2(1), PPAP2A(1), PPAP2B(1)	17686935	73	56	73	24	5	20	24	12	12	0	0.410	1.000	1.000
472	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	18	AKT1(2), CCND1(3), CCNE1(4), CDK4(5), CDK6(1), CDKN1B(2), NFKB1(5), NFKBIA(1), PAK1(3), PIK3R1(9), RAF1(3), RB1(17), RELA(2), TFDP1(2)	12592534	59	56	59	19	4	9	12	8	26	0	0.589	1.000	1.000
473	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(8), ACO2(4), CS(3), DLD(1), DLST(6), FH(3), IDH1(4), IDH2(1), IDH3A(1), IDH3B(1), MDH1(1), MDH2(1), PC(14), PCK1(2), SDHA(6), SDHB(1), SUCLA2(2), SUCLG1(1), SUCLG2(3)	15684655	63	55	62	21	11	17	18	10	7	0	0.290	1.000	1.000
474	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(4), BCAT2(4), COASY(2), DPYD(16), DPYS(7), ENPP1(10), ENPP3(8), ILVBL(5), PANK1(2), PANK2(2), PANK3(2), PANK4(1), PPCS(2), UPB1(1), VNN1(4)	13199243	70	55	70	27	9	15	20	16	10	0	0.753	1.000	1.000
475	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(5), IL22(3), IL22RA1(4), IL22RA2(1), JAK1(10), JAK2(5), JAK3(6), SOCS3(1), STAT1(8), STAT3(6), STAT5A(3), STAT5B(5), TYK2(8)	14004048	65	55	65	28	8	19	18	11	9	0	0.648	1.000	1.000
476	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSA(1), ARSB(2), ARSD(4), ARSE(3), ASAH1(1), GAL3ST1(3), GALC(2), GBA(2), GLA(2), GLB1(5), LCT(17), NEU1(2), NEU2(2), NEU3(1), NEU4(2), PPAP2A(1), PPAP2B(1), SPTLC1(5), SPTLC2(3), UGCG(1)	18404200	60	53	60	30	14	15	15	7	9	0	0.828	1.000	1.000
477	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(9), POLR1B(3), POLR1C(2), POLR2A(12), POLR2B(9), POLR2C(1), POLR2D(1), POLR2E(1), POLR2F(3), POLR2G(4), POLR2H(1), POLR2I(1), POLR2J(2), POLR2L(3), POLR3A(8), POLR3B(4), POLR3G(1), POLR3GL(2), POLR3H(1)	17875206	68	53	68	20	6	15	20	13	14	0	0.363	1.000	1.000
478	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA2(1), ADH1A(2), ADH1B(2), ADH4(2), ADH6(1), ADH7(2), ADHFE1(4), AKR1C4(3), AKR1D1(3), ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), BAAT(2), CEL(2), CYP27A1(2), CYP7A1(6), HADHB(4), SOAT2(2)	17706807	62	52	62	28	11	9	17	15	10	0	0.916	1.000	1.000
479	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(4), CR1(10), CR2(7), FCGR2B(1), HLA-DRA(1), HLA-DRB1(2), ICAM1(6), ITGAL(8), ITGB2(3), PTPRC(18)	11579547	60	52	59	30	3	16	16	9	16	0	0.958	1.000	1.000
480	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(11), EGF(8), EGFR(19), HGS(2), RAB5A(3), TF(5), TFRC(8)	9774048	56	52	56	22	5	11	17	12	10	1	0.869	1.000	1.000
481	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(1), AMD1(4), BHMT(1), CTH(3), DNMT1(11), DNMT3A(13), DNMT3B(9), MARS(2), MARS2(5), MAT1A(1), MTAP(2), MTFMT(4), MTR(8), TAT(2)	15797093	66	52	66	25	8	14	16	12	16	0	0.506	1.000	1.000
482	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	36	G6PD(4), GCLC(4), GCLM(1), GGT1(4), GPX2(1), GPX5(2), GPX6(3), GPX7(1), GSS(3), GSTA1(3), GSTA2(1), GSTA3(2), GSTA5(2), GSTK1(2), GSTM1(1), GSTM2(2), GSTM3(1), GSTM4(4), GSTM5(1), GSTP1(1), GSTT1(1), GSTZ1(1), IDH1(4), IDH2(1), MGST1(1), MGST3(2), OPLAH(7)	16875752	60	52	60	29	10	16	15	12	7	0	0.757	1.000	1.000
483	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	B3GNT1(3), B3GNT2(1), B3GNT3(6), B3GNT5(2), B4GALT1(1), B4GALT2(5), B4GALT3(1), B4GALT4(2), FUT2(2), FUT3(3), FUT5(4), FUT6(2), FUT7(1), FUT9(11), GCNT2(5), ST3GAL6(4), ST8SIA1(3)	12381917	56	52	54	17	8	15	23	5	5	0	0.188	1.000	1.000
484	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	BET1(1), BNIP1(1), GOSR1(4), GOSR2(1), SNAP25(3), STX11(6), STX12(1), STX16(1), STX17(4), STX18(4), STX19(3), STX4(7), STX5(4), STX7(3), STX8(2), TSNARE1(5), USE1(1), VAMP1(3), VAMP5(1), VAMP7(1), VTI1A(1), YKT6(1)	12730801	58	52	57	16	11	13	16	4	14	0	0.221	1.000	1.000
485	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(6), ABCC2(9), ABCG2(4), BCHE(6), CES1(6), CES2(8), CYP3A4(4), CYP3A5(1), UGT1A1(5), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A9(1)	17402190	63	52	63	38	13	11	24	7	8	0	0.985	1.000	1.000
486	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(16), CPT1A(6), LEP(1), LEPR(17), PRKAA1(4), PRKAA2(5), PRKAB1(4), PRKAB2(1), PRKAG2(2)	11017466	56	52	56	29	9	8	18	8	13	0	0.989	1.000	1.000
487	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(3), ALDH18A1(2), ARG1(1), ARG2(1), ASL(2), CKB(4), CKM(3), CKMT1B(2), CPS1(14), GAMT(2), GATM(4), GLUD1(3), NAGS(3), OAT(1), ODC1(3), OTC(2), PYCR1(1), SMS(3)	13356772	54	52	54	17	15	14	14	7	4	0	0.225	1.000	1.000
488	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	26	BAG4(7), BIRC2(3), BIRC3(2), CASP3(2), CFLAR(2), FADD(3), JUN(1), MAP2K4(2), MAP3K3(2), MAP3K7(8), NFKB1(5), NFKB2(5), NFKBIA(1), NFKBIB(1), NFKBIE(1), NFKBIL1(1), NR2C2(1), RALBP1(3), RIPK1(2), TNFAIP3(6), TNFRSF1A(2), TNFRSF1B(2), TRADD(1), TRAF2(2)	19975878	65	51	64	24	15	21	13	7	9	0	0.416	1.000	1.000
489	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(1), CHUK(6), IFNG(2), IKBKB(11), IL2(2), IL4(1), JUN(1), MAP3K1(6), MAP3K5(6), MAP4K5(1), MAPK14(2), MAPK8(4), NFKB1(5), NFKBIA(1), RELA(2), TNFRSF9(4), TNFSF9(1), TRAF2(2)	14818860	58	50	58	19	8	8	21	7	14	0	0.607	1.000	1.000
490	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(6), DUSP1(2), IKBKAP(6), IKBKB(11), MAP3K1(6), NFKB1(5), NFKBIA(1), RELA(2), TNFAIP3(6), TRAF3(6), TRAF6(3)	13852038	54	50	54	17	9	12	15	5	13	0	0.411	1.000	1.000
491	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(3), ALOX15B(6), ALOX5(5), DPEP1(4), GGT1(4), LTA4H(2), PLA2G2A(2), PLA2G6(3), PTGDS(2), PTGIS(7), PTGS1(7), PTGS2(3), TBXAS1(5)	11485005	53	50	53	18	10	11	15	4	13	0	0.205	1.000	1.000
492	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(4), BCAT2(4), IARS(11), IARS2(2), ILVBL(5), LARS(5), LARS2(2), PDHA1(4), PDHA2(14), PDHB(1), VARS(5), VARS2(4)	14201185	61	50	61	20	3	24	18	7	9	0	0.408	1.000	1.000
493	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(1), ACP2(2), ACP5(1), ACP6(5), ACPP(2), ACPT(3), ENPP1(10), ENPP3(8), FLAD1(5), LHPP(1), MTMR1(2), MTMR2(3), MTMR6(3), PHPT1(1), TYR(8)	11450654	55	50	55	16	10	6	23	6	10	0	0.560	1.000	1.000
494	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(4), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), ALDH9A1(3), CYP2C19(6), CYP2C9(6), DHRS1(2), DHRS2(4), DHRS3(1), DHRS7(1), ECHS1(2), EHHADH(5), ESCO1(4), ESCO2(3), HADHA(3), SH3GLB1(1), YOD1(4)	23572958	61	50	61	28	4	14	18	15	10	0	0.934	1.000	1.000
495	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(8), AMT(2), ATIC(5), DHFR(2), FTCD(2), GART(5), MTFMT(4), MTHFD1(6), MTHFD1L(6), MTHFD2(3), MTHFR(2), MTHFS(2), MTR(8), SHMT1(1), SHMT2(3), TYMS(1)	14409956	60	49	60	26	9	7	22	9	12	1	0.889	1.000	1.000
496	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	17	AKT1(2), EIF2B5(6), EIF2S1(2), EIF2S2(6), EIF2S3(1), EIF4E(1), EIF4EBP1(1), GSK3B(3), IGF1(1), IGF1R(11), INPPL1(8), PDK2(1), PDPK1(4), PIK3R1(9), RPS6KB1(4)	12744407	60	49	59	17	10	16	10	9	15	0	0.295	1.000	1.000
497	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CD3D(1), CXCR3(1), ETV5(5), IFNG(2), IL12A(1), IL12B(3), IL12RB1(3), IL12RB2(10), IL18(1), IL18R1(3), JAK2(5), JUN(1), MAP2K6(1), MAPK14(2), MAPK8(4), STAT4(6), TYK2(8)	14222687	57	49	57	22	5	12	16	8	16	0	0.779	1.000	1.000
498	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(3), ICAM1(6), ITGA4(14), ITGAL(8), ITGB1(15), ITGB2(3), SELE(7), SELL(2)	9225121	58	49	57	27	6	14	13	10	15	0	0.861	1.000	1.000
499	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CYB5R3(6), GCK(4), GFPT1(3), GNE(2), GNPDA1(2), HEXA(4), HK1(4), HK2(6), HK3(8), PGM3(1), RENBP(5), UAP1(5)	12907461	50	48	50	15	13	13	9	7	8	0	0.250	1.000	1.000
500	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(2), GALNS(1), GLB1(5), GNS(3), GUSB(5), HEXA(4), IDS(7), IDUA(6), LCT(17), NAGLU(4)	10941517	54	48	54	21	11	14	11	11	7	0	0.496	1.000	1.000
501	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	28	BECN1(2), GABARAPL1(1), IFNA10(1), IFNA14(1), IFNA16(4), IFNA17(3), IFNA2(1), IFNA21(2), IFNA4(3), IFNA6(1), IFNA8(3), IFNG(2), PIK3C3(5), PIK3R4(11), PRKAA1(4), PRKAA2(5), ULK1(7)	14555643	56	48	56	23	7	9	26	10	4	0	0.889	1.000	1.000
502	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	14	CSF2RB(7), FOS(6), IL3(1), IL3RA(5), JAK2(5), MAP2K1(5), PTPN6(3), RAF1(3), SHC1(2), SOS1(9), STAT5A(3), STAT5B(5)	13148465	54	48	54	16	8	15	18	7	6	0	0.207	1.000	1.000
503	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(19), ABCB11(8), ABCB4(13), ABCC1(6), ABCC3(4), GSTP1(1)	10909430	51	48	51	26	7	10	18	3	13	0	0.903	1.000	1.000
504	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	13	AKT1(2), AKT2(4), AKT3(6), BPNT1(2), ILK(4), PDK1(3), PIK3CD(8), PTK2B(4), RBL2(6), SHC1(2), SOS1(9)	12780337	50	48	50	16	11	9	14	11	5	0	0.451	1.000	1.000
505	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(16), ACACB(18), FASN(10), MCAT(3), OLAH(3), OXSM(3)	12100482	53	47	53	21	13	10	13	10	7	0	0.646	1.000	1.000
506	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(4), COASY(2), DPYD(16), DPYS(7), ENPP1(10), ENPP3(8), PANK1(2), PANK2(2), PANK3(2), PANK4(1), PPCS(2), UPB1(1)	10634875	57	47	57	20	8	10	17	14	8	0	0.665	1.000	1.000
507	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(2), GABRA1(12), GABRA2(12), GABRA3(6), GABRA4(4), GABRA5(6), GABRA6(6), GPHN(4), NSF(1), SRC(1), UBQLN1(2)	9131544	56	46	55	23	5	11	22	8	10	0	0.885	1.000	1.000
508	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(1), GPLD1(3), PGAP1(5), PIGA(2), PIGB(3), PIGC(2), PIGG(6), PIGK(6), PIGN(3), PIGO(4), PIGP(1), PIGQ(4), PIGS(3), PIGT(2), PIGU(1), PIGV(1), PIGW(2), PIGX(2), PIGZ(2)	18117596	53	46	53	33	9	13	15	6	10	0	0.992	1.000	1.000
509	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(1), GALNT10(5), GALNT2(7), GALNT3(6), GALNT4(3), GALNT6(4), GALNT7(3), GALNT8(6), GALNT9(1), GCNT1(1), ST3GAL1(2), ST3GAL2(1), ST3GAL4(1), WBSCR17(10)	10998633	51	46	51	18	8	16	14	4	8	1	0.434	1.000	1.000
510	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(8), AMT(2), ATIC(5), ATP6V0C(1), DHFR(2), GART(5), MTHFD1(6), MTHFD1L(6), MTHFD2(3), MTHFR(2), MTHFS(2), MTR(8), SHMT1(1), SHMT2(3), TYMS(1)	13614448	55	46	55	27	9	6	22	8	9	1	0.961	1.000	1.000
511	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(2), GUSB(5), RPE(1), UCHL3(1), UGDH(3), UGT1A1(5), UGT1A10(3), UGT1A3(1), UGT1A4(2), UGT1A5(1), UGT1A6(4), UGT1A7(2), UGT1A9(1), UGT2B15(4), UGT2B4(13)	13402585	48	46	48	29	9	5	15	14	5	0	0.993	1.000	1.000
512	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(5), ESR2(1), PDE1A(6), PDE1B(4), PLCB1(22), PLCB2(6), PRL(3), TRH(2), VIP(1)	8480475	50	46	49	22	6	7	23	9	5	0	0.842	1.000	1.000
513	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	CD2(1), CD33(2), CD5(1), IFNG(2), IL12A(1), IL12B(3), IL13(1), IL3(1), IL4(1), IL5(2), ITGAX(8), TLR2(2), TLR4(17), TLR7(8), TLR9(4)	14182806	54	45	54	28	8	13	16	9	8	0	0.887	1.000	1.000
514	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(4), ACADM(3), ACADS(2), ACADVL(5), ACSL1(3), ACSL3(3), ACSL4(6), CPT1A(6), CPT2(7), EHHADH(5), HADHA(3), SCP2(3), SLC25A20(3)	12805588	53	45	53	21	6	13	12	11	11	0	0.776	1.000	1.000
515	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(11), CD38(5), ENPP1(10), ENPP3(8), NADSYN1(3), NMNAT1(4), NMNAT2(1), NNMT(3), NNT(5), NT5E(1), QPRT(1)	11095576	52	44	52	26	4	7	20	13	8	0	0.970	1.000	1.000
516	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	13	AKT1(2), AKT2(4), AKT3(6), ELK1(2), MAP2K1(5), MAP2K2(6), NGFR(1), NTRK1(3), PIK3CD(8), SHC1(2), SOS1(9)	10319331	48	44	48	18	14	6	13	11	4	0	0.650	1.000	1.000
517	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOA(1), ALDOB(5), ALDOC(4), FBP2(1), GOT1(1), GOT2(2), GPT(1), GPT2(4), MDH1(1), MDH2(1), ME1(2), ME2(3), ME3(7), PGK1(2), PKLR(3), RPE(1), RPIA(3), TKT(3), TPI1(4)	13774293	49	43	49	18	9	10	16	9	5	0	0.565	1.000	1.000
518	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(8), ACO2(4), CS(3), GRHPR(1), HAO1(12), HAO2(1), HYI(2), MDH1(1), MDH2(1), MTHFD1(6), MTHFD1L(6), MTHFD2(3)	9733106	48	43	48	16	7	11	17	7	5	1	0.565	1.000	1.000
519	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(5), CYP51A1(1), DHCR24(2), DHCR7(1), EBP(1), FDFT1(4), FDPS(2), GGCX(7), GGPS1(1), HMGCR(5), HSD17B7(1), IDI1(1), IDI2(1), LSS(4), MVD(2), NQO1(3), NSDHL(2), PMVK(4), TM7SF2(2)	14704322	49	43	49	18	11	12	9	6	11	0	0.510	1.000	1.000
520	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	FUCA2(1), GLB1(5), HEXA(4), LCT(17), MAN2B1(4), MAN2B2(2), MAN2C1(4), MANBA(4), NEU1(2), NEU2(2), NEU3(1), NEU4(2)	15519546	48	43	48	24	15	7	10	7	9	0	0.815	1.000	1.000
521	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(1), BHMT(1), CTH(3), DNMT1(11), DNMT3A(13), DNMT3B(9), MARS(2), MARS2(5), MAT1A(1), MTR(8)	13240828	54	43	54	24	8	12	13	10	11	0	0.718	1.000	1.000
522	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(1), ALG5(2), B4GALT1(1), B4GALT2(5), B4GALT3(1), B4GALT5(3), DDOST(1), DPAGT1(1), DPM1(2), FUT8(2), MAN1A1(2), MAN1B1(4), MGAT1(4), MGAT2(3), MGAT3(4), MGAT4A(2), MGAT4B(3), MGAT5(4), RPN1(2), RPN2(6), ST6GAL1(4)	15270764	57	43	57	22	10	9	15	9	14	0	0.714	1.000	1.000
523	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	12	AKT1(2), BAD(1), CHRNB1(1), CHRNG(8), MUSK(8), PIK3R1(9), PTK2(8), PTK2B(4), SRC(1), TERT(3), YWHAH(2)	10826331	47	42	47	21	6	8	14	8	11	0	0.790	1.000	1.000
524	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(12), GABRA2(12), GABRA3(6), GABRA4(4), GABRA5(6), GABRA6(6), PRKCE(3), SOD1(1)	5995337	50	42	49	18	4	8	20	7	11	0	0.759	1.000	1.000
525	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	30	G6PD(4), GCLC(4), GCLM(1), GGT1(4), GPX2(1), GPX5(2), GSS(3), GSTA1(3), GSTA2(1), GSTA3(2), GSTM1(1), GSTM2(2), GSTM3(1), GSTM4(4), GSTM5(1), GSTP1(1), GSTT1(1), GSTZ1(1), IDH1(4), IDH2(1), MGST1(1), MGST3(2), PGD(2)	13775877	47	42	47	20	10	12	10	9	6	0	0.591	1.000	1.000
526	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(1), CD28(3), CD3D(1), CD8A(3), ICAM1(6), ITGAL(8), ITGB2(3), PTPRC(18), THY1(2)	8190989	45	42	45	23	3	7	10	9	16	0	0.890	1.000	1.000
527	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREB1(1), CREM(1), FOS(6), JUN(1), OPRK1(6), POLR2A(12), PRKACB(3), PRKACG(2), PRKAR1A(4), PRKAR1B(4), PRKAR2B(3)	9827059	43	41	43	16	8	13	10	6	6	0	0.470	1.000	1.000
528	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(8), EGFR(19), ERBB3(17), NRG1(1)	7846179	45	41	45	16	6	9	12	12	5	1	0.710	1.000	1.000
529	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(3), B3GNT2(1), B3GNT7(3), B4GALT1(1), B4GALT2(5), B4GALT3(1), B4GALT4(2), CHST1(4), CHST2(6), CHST4(4), CHST6(8), FUT8(2), ST3GAL1(2), ST3GAL2(1), ST3GAL3(4), ST3GAL4(1)	9606047	48	41	48	25	20	8	14	2	4	0	0.883	1.000	1.000
530	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(5), AOC2(6), AOC3(5), CES1(6), DDHD1(4), ESCO1(4), ESCO2(3), LIPA(3), PLA1A(8), PPME1(1), PRDX6(1), SH3GLB1(1)	19334932	47	41	47	12	5	12	16	8	6	0	0.290	1.000	1.000
531	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(4), ADSS(4), DHFR(2), HPRT1(2), IMPDH1(3), MTHFD2(3), NME2(1), OAZ1(2), POLB(1), POLD1(11), POLG(8), PRPS2(2), RRM1(2)	9551451	45	41	45	17	12	5	17	2	9	0	0.653	1.000	1.000
532	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	8	CISH(1), JAK1(10), JAK2(5), JAK3(6), PIAS1(1), PIAS3(4), PTPRU(10), SOAT1(5)	10163525	42	41	42	13	11	7	10	7	7	0	0.362	1.000	1.000
533	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	17	ACTA1(4), ACTR2(1), ARPC1B(3), ARPC2(2), ARPC3(1), ARPC4(1), NCK1(5), NCKAP1(8), NTRK1(3), PIR(1), WASF1(3), WASF2(5), WASF3(6), WASL(2)	11288049	45	40	45	20	11	10	11	9	4	0	0.884	1.000	1.000
534	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARF1(1), ARFGAP1(3), ARFGAP3(4), ARFGEF2(14), CLTA(1), CLTB(1), COPA(6), GBF1(12), GPLD1(3), KDELR1(1)	12355779	46	40	46	17	5	15	12	6	8	0	0.505	1.000	1.000
535	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	19	BAD(1), BCL2(1), FADD(3), MAP2K1(5), MAP2K4(2), MAP3K1(6), MAPK8(4), NFKB1(5), NSMAF(6), RAF1(3), RELA(2), RIPK1(2), TNFRSF1A(2), TRADD(1), TRAF2(2)	14290201	45	40	45	22	10	5	16	6	8	0	0.952	1.000	1.000
536	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(8), CD44(3), CSF1(2), FCGR3A(7), IL1B(1), IL6R(6), SELL(2), SPN(3), TGFB1(1), TGFB2(4), TNFRSF1A(2), TNFRSF1B(2), TNFRSF8(2), TNFSF8(2)	10061449	45	40	45	19	7	12	11	10	5	0	0.620	1.000	1.000
537	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(1), CD28(3), CD3D(1), CD4(1), ICAM1(6), ITGAL(8), ITGB2(3), PTPRC(18), THY1(2)	8595033	43	40	43	23	2	7	10	10	14	0	0.921	1.000	1.000
538	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	ALDOA(1), CTSD(5), ESR1(5), GREB1(20), HSPB2(2), MTA1(7), MTA3(2), TUBA8(2)	8366204	44	39	44	20	12	4	15	7	6	0	0.768	1.000	1.000
539	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT2(2), ACOT11(4), ACYP1(1), DHRS1(2), DHRS2(4), DHRS3(1), DHRS7(1), ECHS1(2), EHHADH(5), ESCO1(4), ESCO2(3), FN3K(3), GCDH(2), HADHA(3), SH3GLB1(1), YOD1(4)	19815473	42	38	42	16	2	11	10	11	8	0	0.717	1.000	1.000
540	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(3), CAT(4), EPX(9), MPO(7), MTHFR(2), PRDX6(1), SHMT1(1), SHMT2(3), TPO(12)	8848244	42	38	41	23	15	6	14	4	3	0	0.940	1.000	1.000
541	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(4), PSMA2(1), PSMA3(2), PSMA4(1), PSMA5(1), PSMA6(2), PSMB1(1), PSMB2(1), PSMB3(1), PSMB4(2), PSMB5(3), PSMB6(1), PSMB7(1), PSMC2(6), PSMC3(2), PSMD1(6), PSMD11(1), PSMD12(1), PSMD13(2), PSMD2(5)	12173900	44	38	44	14	3	8	16	11	6	0	0.605	1.000	1.000
542	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(3), ATP6V0C(1), CAT(4), EPX(9), MPO(7), PRDX2(2), PRDX6(1), SHMT1(1), SHMT2(3), TPO(12)	8997307	43	38	42	23	14	6	14	6	3	0	0.938	1.000	1.000
543	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	FUCA2(1), GLB1(5), HEXA(4), LCT(17), MAN2C1(4), MANBA(4), NEU1(2), NEU2(2), NEU3(1), NEU4(2)	12593698	42	38	42	20	12	6	10	7	7	0	0.783	1.000	1.000
544	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(3), LDLR(4), MBTPS1(11), MBTPS2(4), SCAP(8), SREBF1(5), SREBF2(5)	9071949	40	38	39	14	6	7	13	9	5	0	0.640	1.000	1.000
545	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	C9orf47(1), CNR1(3), DNMT1(11), MTNR1A(3), MTNR1B(3), PTGDR(3), PTGER2(5), PTGER4(8), PTGFR(2), PTGIR(3), TBXA2R(1)	8535020	43	38	42	25	8	8	16	5	6	0	0.876	1.000	1.000
546	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(6), MAPK14(2), MAPK8(4), NFKB1(5), RELA(2), TNFRSF13B(1), TNFRSF13C(2), TNFSF13(1), TNFSF13B(3), TRAF2(2), TRAF3(6), TRAF5(1), TRAF6(3)	11119036	38	38	37	13	4	9	12	2	11	0	0.571	1.000	1.000
547	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(2), CLOCK(6), CRY1(6), CRY2(3), CSNK1D(1), CSNK1E(6), NPAS2(2), NR1D1(1), PER1(7), PER2(2), PER3(6)	13012064	42	37	42	17	11	9	10	9	3	0	0.638	1.000	1.000
548	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(2), IL4(1), IL4R(8), IRS1(2), JAK1(10), JAK3(6), RPS6KB1(4), SHC1(2), STAT6(5)	11249390	40	37	40	13	6	10	11	7	6	0	0.326	1.000	1.000
549	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6AP1(2), ATP6V0A1(4), ATP6V0A4(6), ATP6V0B(1), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(4), ATP6V1C1(4), ATP6V1C2(3), ATP6V1D(2), ATP6V1E1(2), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(3), ATP6V1H(3), FDXR(3), SHMT1(1)	12176994	48	37	48	15	7	9	16	9	7	0	0.479	1.000	1.000
550	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(1), ACP2(2), ACP5(1), ACPP(2), ACPT(3), ENPP1(10), ENPP3(8), FLAD1(5), TYR(8)	7402625	40	37	40	13	5	5	19	4	7	0	0.673	1.000	1.000
551	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	12	ACTR2(1), ARPC1B(3), ARPC2(2), ARPC3(1), ARPC4(1), CDC42(3), PAK1(3), PDGFRA(13), PIK3R1(9), WASL(2)	8196067	38	36	38	14	4	6	13	6	9	0	0.871	1.000	1.000
552	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	MRPS7(1), RPL10A(1), RPL10L(6), RPL12(1), RPL13A(2), RPL18A(1), RPL26(1), RPL27(1), RPL3(5), RPL31(2), RPL32(1), RPL37(2), RPL37A(1), RPL39(1), RPL3L(1), RPL6(2), RPL8(1), RPS10(2), RPS13(2), RPS15A(1), RPS20(1), RPS23(1), RPS25(2), RPS28(1), RPS3(2), RPS5(1)	17304999	43	36	43	24	4	10	17	4	8	0	0.954	1.000	1.000
553	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(3), HMOX1(1), IL10RA(5), IL10RB(1), IL1A(1), IL6(2), JAK1(10), STAT1(8), STAT3(6), STAT5A(3)	9275295	40	36	40	19	3	15	10	6	6	0	0.600	1.000	1.000
554	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	7	IFNAR1(2), JAK1(10), PTPRU(10), STAT1(8), STAT2(4), TYK2(8)	9259532	42	36	42	20	10	10	8	4	10	0	0.793	1.000	1.000
555	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(2), ATP6V0A1(4), ATP6V0A4(6), ATP6V0B(1), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(4), ATP6V1C1(4), ATP6V1C2(3), ATP6V1D(2), ATP6V1E1(2), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(3), ATP6V1H(3), SHMT1(1)	11439698	45	35	45	13	6	9	14	9	7	0	0.369	1.000	1.000
556	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(7), EIF2AK4(7), EIF2B5(6), EIF2S1(2), EIF2S2(6), EIF2S3(1), EIF5(3), GSK3B(3), PPP1CA(1)	8820515	36	35	36	14	4	9	10	6	7	0	0.836	1.000	1.000
557	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(2), ATP6V0A1(4), ATP6V0A4(6), ATP6V0B(1), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(4), ATP6V1C1(4), ATP6V1C2(3), ATP6V1D(2), ATP6V1E1(2), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(3), ATP6V1H(3), SHMT1(1)	11439698	45	35	45	13	6	9	14	9	7	0	0.369	1.000	1.000
558	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	12	ARNT(9), ASPH(10), COPS5(2), CREB1(1), EDN1(1), EPO(2), HIF1A(4), JUN(1), LDHA(1), NOS3(4), P4HB(1)	9188341	36	35	36	13	7	11	7	8	3	0	0.539	1.000	1.000
559	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CD2(1), CD3D(1), CD4(1), CXCR3(1), IFNG(2), IL12A(1), IL12B(3), IL12RB1(3), IL12RB2(10), JAK2(5), STAT4(6), TYK2(8)	11195854	42	35	42	19	4	9	12	7	10	0	0.848	1.000	1.000
560	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	NFKB1(5), NFKBIA(1), PLCB1(22), PRKCA(7), RELA(2)	6288248	37	35	36	12	5	6	15	6	5	0	0.492	1.000	1.000
561	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(2), ATP6V0A1(4), ATP6V0A4(6), ATP6V0B(1), ATP6V0C(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(4), ATP6V1C1(4), ATP6V1C2(3), ATP6V1D(2), ATP6V1E1(2), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(3), ATP6V1H(3), SHMT1(1)	11439698	45	35	45	13	6	9	14	9	7	0	0.369	1.000	1.000
562	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(4), IARS(11), LARS(5), LARS2(2), PDHA1(4), PDHA2(14), PDHB(1)	7619969	41	35	41	12	0	16	13	6	6	0	0.513	1.000	1.000
563	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(2), CYSLTR2(6), GPR161(4), GPR171(2), GPR18(1), GPR34(1), GPR39(7), GPR45(5), GPR65(2), GPR68(2), GPR75(5)	7498683	37	34	37	17	11	7	7	7	5	0	0.746	1.000	1.000
564	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(4), CARS2(1), CDO1(2), CTH(3), GOT1(1), GOT2(2), LDHA(1), LDHAL6A(2), LDHAL6B(6), LDHB(1), LDHC(4), MPST(2), SDS(1), SULT1B1(3), SULT1C2(3), SULT1C4(2), SULT4A1(1)	9547972	39	34	39	14	8	5	14	7	5	0	0.617	1.000	1.000
565	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(9), MPO(7), PRDX2(2), PRDX6(1), TPO(12), TYR(8)	7358360	39	34	38	19	11	4	16	5	3	0	0.892	1.000	1.000
566	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(2), CHAT(9), PCYT1A(2), PDHA1(4), PDHA2(14), SLC18A3(6)	5344444	37	33	37	19	4	10	14	4	5	0	0.874	1.000	1.000
567	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(4), ACAD9(2), ADH1A(2), ADH1B(2), ADH4(2), ADH5(3), ADH6(1), ADH7(2), ADHFE1(4), DHRS1(2), DHRS2(4), DHRS3(1), DHRS7(1), ESCO1(4), ESCO2(3), SH3GLB1(1)	19028846	38	33	38	16	3	11	6	8	10	0	0.808	1.000	1.000
568	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(3), ICAM1(6), ITGAL(8), ITGAM(8), ITGB2(3), SELE(7), SELL(2)	7905087	37	33	37	24	3	9	7	5	13	0	0.963	1.000	1.000
569	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(1), IL13RA1(2), IL13RA2(4), IL4R(8), JAK1(10), JAK2(5), TYK2(8)	7987723	38	33	38	15	8	8	9	7	6	0	0.674	1.000	1.000
570	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(1), IL13RA1(2), IL13RA2(4), IL4R(8), JAK1(10), JAK2(5), TYK2(8)	7987723	38	33	38	15	8	8	9	7	6	0	0.674	1.000	1.000
571	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(4), ACO1(8), ACO2(4), ACSS1(6), ACSS2(2), FH(3), IDH1(4), IDH2(1), MDH1(1), MDH2(1), SUCLA2(2)	10126876	36	32	36	14	5	11	12	2	6	0	0.569	1.000	1.000
572	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CD4(1), CSF1(2), HLA-DRA(1), HLA-DRB1(2), IFNG(2), IL12A(1), IL12B(3), IL13(1), IL1A(1), IL2(2), IL3(1), IL4(1), IL5(2), IL6(2), IL7(2), LTA(4), TGFB1(1), TGFB2(4), TGFB3(1)	10139640	34	32	33	16	5	7	8	8	6	0	0.868	1.000	1.000
573	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3), ECHS1(2), EHHADH(5), HADHA(3), SDS(1)	9263996	35	32	35	15	5	5	10	9	6	0	0.855	1.000	1.000
574	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3D(1), CD4(1), FYN(4), HLA-DRA(1), HLA-DRB1(2), LCK(5), PTPRC(18), ZAP70(4)	6887652	36	32	35	17	3	6	9	7	11	0	0.900	1.000	1.000
575	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(5), ENO1(2), GPI(3), HK1(4), PFKL(6), PGAM1(2), PGK1(2), PKLR(3), TPI1(4)	7067770	31	30	31	11	7	8	5	4	7	0	0.449	1.000	1.000
576	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	AKR1B10(4), DHRS1(2), DHRS2(4), DHRS3(1), DHRS7(1), HSD3B7(2), PON1(4), PON2(2), PON3(8), RDH11(2), RDH12(4)	6856410	34	30	33	17	3	7	10	9	5	0	0.876	1.000	1.000
577	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNAR1(2), IFNAR2(2), JAK1(10), STAT1(8), STAT2(4), TYK2(8)	8272766	34	30	34	16	5	9	7	4	9	0	0.799	1.000	1.000
578	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	6	JAK1(10), JAK2(5), JAK3(6), STAT3(6), TYK2(8)	8406722	35	30	35	13	5	6	10	9	5	0	0.572	1.000	1.000
579	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(3), AKR1D1(3), CYP11A1(3), CYP11B1(6), CYP11B2(4), CYP17A1(1), HSD11B2(3), HSD3B1(4), HSD3B2(4)	7026894	31	29	31	13	10	3	8	5	4	1	0.693	1.000	1.000
580	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(3), AKR1D1(3), CYP11A1(3), CYP11B1(6), CYP11B2(4), CYP17A1(1), HSD11B2(3), HSD3B1(4), HSD3B2(4)	7026894	31	29	31	13	10	3	8	5	4	1	0.693	1.000	1.000
581	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(2), ADH1B(2), ADH4(2), ADH5(3), ADH6(1), ADH7(2), ADHFE1(4), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), ALDH9A1(3)	10077353	31	29	31	15	5	7	6	7	6	0	0.876	1.000	1.000
582	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(4), CS(3), FH(3), IDH2(1), MDH1(1), OGDH(10), SDHA(6), SUCLA2(2)	7163508	30	29	29	10	5	4	12	5	4	0	0.630	1.000	1.000
583	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(1), CTH(3), GGT1(4), MARS(2), MARS2(5), MAT1A(1), PAPSS1(6), PAPSS2(6), SCLY(1), SEPHS1(2)	9427406	31	29	31	12	8	9	7	5	2	0	0.521	1.000	1.000
584	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(2), CLOCK(6), CRY1(6), CRY2(3), CSNK1E(6), PER1(7)	6503926	30	28	30	11	6	6	8	9	1	0	0.632	1.000	1.000
585	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(9), GBA(2), MPO(7), PRDX6(1), TPO(12)	6384044	31	28	30	17	11	4	11	3	2	0	0.914	1.000	1.000
586	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	7	ACE(8), AGT(4), AGTR2(2), BDKRB2(3), KNG1(4), NOS3(4), REN(3)	6965932	28	27	28	15	5	7	8	3	5	0	0.815	1.000	1.000
587	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	CYP51A1(1), DHCR7(1), FDFT1(4), FDPS(2), HMGCR(5), HMGCS1(3), IDI1(1), LSS(4), MVD(2), NSDHL(2), PMVK(4)	10055090	29	26	29	12	9	9	3	4	4	0	0.512	1.000	1.000
588	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	15	CD28(3), CD3D(1), IFNG(2), IL2(2), IL2RA(2), IL4(1), TGFB1(1), TGFB2(4), TGFB3(1), TGFBR1(2), TGFBR3(5), TOB2(3)	7172045	27	26	27	10	2	5	8	8	4	0	0.769	1.000	1.000
589	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	AKR1A1(1), ECHS1(2), EHHADH(5), HADH(4), HADHA(3), HSD17B10(1), HSD17B4(5), NTAN1(1), SIRT1(3), SIRT2(1), SIRT5(2), SIRT7(1), VNN2(2)	9027467	31	25	31	12	0	11	10	5	5	0	0.769	1.000	1.000
590	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(2), ENO2(1), ENO3(3), FARS2(5), GOT1(1), GOT2(2), PAH(7), TAT(2), YARS(6)	6320693	29	25	29	11	0	9	11	3	6	0	0.603	1.000	1.000
591	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYC(2), RB1(17), SP1(3), SP3(3)	5062287	25	25	25	10	0	2	5	4	14	0	0.918	1.000	1.000
592	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	8	CD3D(1), GZMB(2), ICAM1(6), ITGAL(8), ITGB2(3), PRF1(5)	5911191	25	24	25	14	4	5	5	2	9	0	0.754	1.000	1.000
593	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	13	ARF1(1), CCND1(3), CDK4(5), CDKN1B(2), CFL1(2), E2F2(3), MDM2(3), PRB1(7)	5376969	26	24	26	11	1	6	10	6	3	0	0.824	1.000	1.000
594	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3)	6087277	24	23	24	12	5	2	7	6	4	0	0.912	1.000	1.000
595	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A2(10), ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH9A1(3)	6087277	24	23	24	12	5	2	7	6	4	0	0.912	1.000	1.000
596	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(1), FDFT1(4), FDPS(2), HMGCR(5), IDI1(1), LSS(4), MVD(2), NQO1(3), PMVK(4)	8439908	26	23	26	10	10	8	2	2	4	0	0.386	1.000	1.000
597	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(3), ALPL(4), ALPP(5), ALPPL2(7), DHFR(2), FPGS(1), GCH1(1), GGH(2)	4994142	25	23	25	12	5	2	12	3	3	0	0.819	1.000	1.000
598	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACOX1(2), ACOX3(1), ELOVL2(1), ELOVL5(1), ELOVL6(1), FADS1(1), FADS2(4), FASN(10), HADHA(3), SCD(1)	10947614	25	23	25	17	5	8	6	2	4	0	0.939	1.000	1.000
599	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(3), PLCG1(9), PRKCA(7), PTK2B(4)	5113158	23	23	23	10	5	4	9	4	1	0	0.633	1.000	1.000
600	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	10	CDK5(3), CDK5R1(1), EGR1(4), KLK2(2), MAP2K1(5), MAP2K2(6), NGFR(1), RAF1(3)	5391156	25	22	25	12	8	4	8	2	3	0	0.628	1.000	1.000
601	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GSS(3), NFKB1(5), NOX1(6), RELA(2), SOD1(1), XDH(6)	7546546	23	22	23	13	4	5	6	4	4	0	0.883	1.000	1.000
602	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(1), ALDH1B1(4), ALDH2(2), ALDH3A1(1), ALDH3A2(2), ALDH7A1(2), ALDH9A1(3), MIOX(4), UGDH(3)	6483880	22	22	22	10	5	3	4	7	3	0	0.765	1.000	1.000
603	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	8	MMP14(4), MMP2(5), MMP9(1), RECK(10), TIMP1(1), TIMP2(1), TIMP4(1)	5397957	23	22	23	18	2	8	5	6	2	0	0.989	1.000	1.000
604	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(1), ASL(2), CPS1(14), GLS(1), GLUD1(3), GOT1(1)	5941839	22	22	22	10	4	4	6	5	3	0	0.822	1.000	1.000
605	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(5), CYP11A1(3), CYP11B2(4), CYP17A1(1), HSD11B2(3), HSD3B1(4), HSD3B2(4)	5262994	24	21	24	15	7	3	7	2	4	1	0.901	1.000	1.000
606	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(2), ACOX3(1), FADS2(4), PLA2G12A(1), PLA2G12B(1), PLA2G1B(2), PLA2G2A(2), PLA2G2D(2), PLA2G3(2), PLA2G4A(3), PLA2G5(1), PLA2G6(3)	7724314	24	21	24	14	3	6	9	1	5	0	0.904	1.000	1.000
607	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(3), ADORA2A(3), ADORA2B(1), ADORA3(3), LTB4R(3), P2RY1(5), P2RY2(3), P2RY6(1)	4552714	22	20	21	10	3	7	8	2	2	0	0.515	1.000	1.000
608	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	11	ACTA1(4), ACTR2(1), ARPC1B(3), ARPC2(2), ARPC3(1), ARPC4(1), CDC42(3), WASF1(3), WASL(2)	5857986	20	20	20	13	4	5	5	4	2	0	0.973	1.000	1.000
609	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(5), CYP2A13(4), CYP2A6(2), CYP2A7(3), NAT1(2), XDH(6)	6080283	22	19	22	10	3	5	9	3	2	0	0.757	1.000	1.000
610	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAD(2), ALAS2(4), CPO(4), FECH(1), GATA1(1), HBA2(2), UROD(1), UROS(3)	5951609	18	18	18	11	2	3	6	6	1	0	0.949	1.000	1.000
611	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	9	BAG4(7), BIRC3(2), FADD(3), RIPK1(2), TNFRSF1A(2), TNFRSF1B(2), TRADD(1), TRAF2(2)	5535900	21	18	21	11	5	6	5	3	2	0	0.779	1.000	1.000
612	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(2), ALDOA(1), ALDOB(5), ALDOC(4), TPI1(4)	2985343	16	16	16	7	1	6	4	5	0	0	0.692	1.000	1.000
613	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	CKM(3), EIF4E(1), GPT(1), LDHA(1), LDHB(1), LDHC(4), MAPK14(2), NCL(4)	6849192	17	16	17	11	3	2	4	4	4	0	0.969	1.000	1.000
614	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(4), EPHX2(4), HSD3B7(2), RDH11(2), RDH12(4)	3653050	16	15	16	7	3	3	7	3	0	0	0.695	1.000	1.000
615	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS1(2), DHRS2(4), DHRS3(1), DHRS7(1), ESCO1(4), ESCO2(3), SH3GLB1(1)	12644033	16	15	16	9	0	4	3	4	5	0	0.944	1.000	1.000
616	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	5	BCL2(1), CASP3(2), CFL1(2), CFLAR(2)	2064270	7	7	7	5	2	5	0	0	0	0	0.743	1.000	1.000
