rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(4), ANAPC10(1), ANAPC2(2), ANAPC4(5), ANAPC5(4), ANAPC7(3), BTRC(4), CDC16(4), CDC20(3), CDC23(3), CDC27(10), CUL1(5), CUL2(4), CUL3(17), FBXW11(1), FBXW7(5), FZR1(4), ITCH(1), RBX1(1), SKP2(2), SMURF1(1), SMURF2(4), TCEB1(4), TCEB2(1), UBA1(4), UBE2D1(2), UBE2D2(1), UBE2D3(2), UBE2E2(1), VHL(241), WWP1(7), WWP2(4)	48311765	355	309	250	22	15	20	45	104	167	4	4.76e-12	<1.00e-15	<3.08e-13
2	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	ARNT(2), EIF1(2), EIF2B1(1), EIF2B2(1), EIF2B3(1), EIF2B4(1), EIF2B5(3), EIF2S2(2), EIF2S3(2), FLT1(8), FLT4(15), HIF1A(5), HRAS(1), KDR(6), NOS3(3), PIK3CA(16), PIK3R1(5), PLCG1(3), PRKCA(3), PTK2(3), PXN(3), SHC1(4), VHL(241)	40195015	331	284	225	25	21	26	34	87	161	2	7.36e-10	<1.00e-15	<3.08e-13
3	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(2), ASPH(1), COPS5(2), CREB1(1), EP300(16), HIF1A(5), JUN(2), NOS3(3), P4HB(2), VHL(241)	19872252	275	249	173	15	9	11	29	72	152	2	1.70e-09	1.67e-15	3.42e-13
4	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	7	HDAC1(2), MAX(5), MYC(1), SP1(2), SP3(3), TP53(50), WT1(3)	8263058	66	56	57	5	4	7	6	21	24	4	0.000553	4.31e-14	6.63e-12
5	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	15	ARF1(1), ARF3(3), CDK2(2), CDK4(7), CDKN1A(3), CDKN1B(1), CDKN2A(4), CFL1(1), E2F1(1), E2F2(1), NXT1(1), PRB1(6), TP53(50)	9636795	81	65	64	7	4	6	9	20	37	5	0.00144	8.19e-14	1.01e-11
6	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	9	CHUK(2), DNAJC3(2), EIF2S2(2), NFKB1(1), NFKBIA(1), RELA(7), TP53(50)	11781948	65	54	53	3	4	10	5	17	24	5	8.72e-05	6.90e-11	7.08e-09
7	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	19	ABCB1(6), AKT1(1), ATM(23), BAX(1), CDKN1A(3), CPB2(6), CSNK1A1(2), FHL2(1), HIC1(1), HIF1A(5), HSPA1A(1), IGFBP3(1), NFKBIB(2), TP53(50)	24711057	103	87	90	7	7	12	11	30	37	6	2.22e-05	2.43e-08	2.14e-06
8	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	AKT1(1), AKT2(4), AKT3(2), BPNT1(3), GRB2(3), ILK(4), MAPK1(1), MAPK3(3), PDK1(1), PIK3CA(16), PIK3CD(2), PTEN(35), PTK2B(4), RBL2(3), SHC1(4), SOS1(7)	23851936	93	81	85	5	7	18	9	22	33	4	6.87e-06	2.08e-07	1.60e-05
9	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	16	APAF1(4), ATM(23), BAX(1), CCNE1(1), CDK2(2), CDK4(7), CDKN1A(3), E2F1(1), PCNA(3), RB1(4), TIMP3(4), TP53(50)	21482122	103	75	87	9	6	10	11	25	44	7	0.000712	7.01e-06	0.000479
10	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	12	ATM(23), CDC25A(2), CDC25B(1), CDC25C(4), CDK2(2), CDK4(7), CHEK1(1), MYT1(9), RB1(4), TP53(50), WEE1(2)	21017184	105	83	92	12	7	16	13	29	34	6	0.000996	0.000297	0.0183
11	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	16	ABL1(6), CDKN2A(4), E2F1(1), MYC(1), PIK3CA(16), PIK3R1(5), POLR1A(10), POLR1B(4), POLR1C(2), POLR1D(1), RB1(4), TP53(50)	23457521	104	85	89	11	7	21	7	31	32	6	0.000115	0.000339	0.0190
12	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	18	DNAJA3(3), HSPA1A(1), IFNG(2), IFNGR1(3), IFNGR2(2), IKBKB(3), JAK2(7), NFKB1(1), NFKBIA(1), RB1(4), RELA(7), TNF(1), TNFRSF1A(1), TNFRSF1B(2), TP53(50), USH1C(4), WT1(3)	21895962	95	79	83	10	5	10	8	27	38	7	0.00319	0.000487	0.0250
13	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD28(1), CD4(10), HLA-DRA(1), HLA-DRB1(6)	2581011	18	17	12	3	1	3	1	3	9	1	0.617	0.00994	0.471
14	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(3), ACADM(3), ACADS(3), ACAT1(1), ECHS1(3), HADHA(4)	6407869	17	17	16	0	3	3	6	5	0	0	0.00312	0.0139	0.575
15	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(2), ARG1(2), GLS(9), GLUD1(1), OAT(3), PRODH(2)	6632902	19	19	19	0	1	2	9	3	4	0	0.00600	0.0140	0.575
16	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	AKT1(1), BCAR1(5), CDKN1B(1), GRB2(3), ILK(4), ITGB1(6), MAPK1(1), MAPK3(3), PDK2(4), PIK3CA(16), PIK3R1(5), PTEN(35), PTK2(3), SHC1(4), SOS1(7)	22810884	98	84	90	14	7	17	7	23	39	5	0.0361	0.0203	0.781
17	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(2), ASL(4), CPS1(5), GLS(9), GLUD1(1), GOT1(3)	9142446	24	24	24	1	0	4	5	7	8	0	0.0266	0.0218	0.791
18	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(2), AASDH(6), AASDHPPT(3), AASS(9), KARS(1)	8277290	21	21	21	1	0	5	5	7	4	0	0.0264	0.0257	0.875
19	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CCR5(1), CD28(1), CD3E(1), CD3G(2), CD4(10)	3850233	15	15	9	1	1	1	1	3	8	1	0.476	0.0270	0.875
20	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(9), GLS2(4), GLUD1(1), GLUD2(1)	5253148	15	15	15	0	1	2	4	6	2	0	0.0228	0.0303	0.932
21	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	AKT1(1), EIF2B5(3), EIF2S2(2), EIF2S3(2), EIF4E(2), GSK3B(3), IGF1R(4), INPPL1(4), PDK2(4), PIK3CA(16), PIK3R1(5), PPP2CA(1), PTEN(35), RPS6KB1(2)	23477583	84	74	76	10	7	13	6	19	35	4	0.0106	0.0327	0.960
22	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(2), AASDHPPT(3), AASS(9), KARS(1)	5630342	15	15	15	1	0	3	4	5	3	0	0.0923	0.0401	1.000
23	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	AKT1(1), AKT2(4), AKT3(2), CDKN1A(3), ELK1(2), GRB2(3), HRAS(1), MAP2K2(1), NGFR(2), NTRK1(6), PIK3CA(16), PIK3CD(2), SHC1(4), SOS1(7)	18793182	54	52	47	5	4	16	3	22	8	1	0.000711	0.0425	1.000
24	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1	CMBL(3)	605111	3	3	3	0	0	0	0	1	2	0	0.858	0.0540	1.000
25	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(3), GOT1(3), GOT2(3), TAT(3), TYR(5)	5574296	17	17	17	2	3	1	3	4	6	0	0.255	0.0558	1.000
26	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	13	CREBBP(13), DAXX(6), HRAS(1), PAX3(2), PML(3), RARA(4), RB1(4), SIRT1(5), SP100(2), TNF(1), TNFRSF1A(1), TNFRSF1B(2), TP53(50)	21851266	94	80	85	15	9	10	12	28	29	6	0.0124	0.0619	1.000
27	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(2), CSF1R(8), EGF(5), EGFR(10), GRB2(3), MET(28), PDGFRA(6), PRKCA(3), SH3GLB1(3), SH3GLB2(1), SH3KBP1(3), SRC(2)	23003961	74	67	62	9	6	14	13	24	17	0	0.00534	0.0634	1.000
28	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(3), RANBP1(2), RANBP2(26), RANGAP1(1)	9694037	32	29	26	3	2	7	4	9	10	0	0.0261	0.0652	1.000
29	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(3), GOT2(3), TAT(3)	3127345	9	9	9	1	2	1	2	0	4	0	0.339	0.0768	1.000
30	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(1), ECHS1(3), EHHADH(6), HADHA(4)	5764259	14	14	13	1	1	3	5	3	2	0	0.0453	0.102	1.000
31	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GGT1(4), SHMT1(4), SHMT2(6)	4859216	14	14	14	2	2	1	3	4	4	0	0.226	0.104	1.000
32	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(8), PDXK(2), PDXP(2), PSAT1(2)	5648478	14	14	14	1	3	1	1	6	3	0	0.147	0.104	1.000
33	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(4), ACAT1(1), ECHS1(3), EHHADH(6), HADHA(4), HADHB(4)	9971050	22	22	21	1	1	4	6	8	3	0	0.00990	0.110	1.000
34	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD28(1), CD4(10), CD80(1), HLA-DRA(1), HLA-DRB1(6), IL2(1), IL4(1)	4468504	21	20	15	4	2	3	2	4	9	1	0.577	0.122	1.000
35	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	FOS(1), FYN(2), JUN(2), MAPK14(2), THBS1(16)	8481542	23	21	20	2	1	2	5	8	7	0	0.119	0.122	1.000
36	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(2), CD34(2), CD3E(1), CD3G(2), CD4(10), CD58(1), CD8A(1), IL3(1), KITLG(2)	7383119	22	20	16	2	1	2	2	5	11	1	0.382	0.136	1.000
37	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	7	ATM(23), ATR(11), CDC25C(4), CHEK1(1), CHEK2(3), TP53(50)	18985809	92	75	82	13	7	12	10	28	31	4	0.0231	0.153	1.000
38	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ACTR2(2), ACTR3(1), ARPC1B(1), ARPC2(8), CDC42(1), PAK1(4), PDGFRA(6), PIK3CA(16), PIK3R1(5), WASL(9)	15936942	53	51	41	7	4	12	5	17	15	0	0.0357	0.175	1.000
39	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(2), PGLYRP2(5)	2038596	7	7	7	2	1	1	0	4	1	0	0.687	0.211	1.000
40	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	15	AKT1(1), EGFR(10), IGF1R(4), MYC(1), POLR2A(11), PPP2CA(1), PRKCA(3), RB1(4), TEP1(10), TERF1(1), TERT(10), TNKS(5), TP53(50), XRCC5(5)	32958243	116	90	105	17	13	16	12	33	36	6	0.00127	0.215	1.000
41	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(1), ECHS1(3), EHHADH(6), GCDH(5), HADHA(4), SDHB(1)	9237301	20	20	17	1	2	4	5	4	5	0	0.0205	0.222	1.000
42	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(3), CD3E(1), CD3G(2), HLA-A(6), ICAM1(3), ITGAL(6), ITGB2(2), PRF1(1)	9870315	24	23	24	2	0	5	3	10	6	0	0.0538	0.229	1.000
43	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(4), GPD2(2), NDUFA1(1), SDHA(8), SDHB(1), SDHD(2), UQCRC1(2)	7707246	20	18	20	3	4	7	3	5	1	0	0.0813	0.240	1.000
44	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(1), RAB11A(1), RAB1A(2), RAB3A(3), RAB4A(1), RAB5A(1), RAB6A(2)	4994451	11	11	11	1	1	1	1	5	3	0	0.261	0.244	1.000
45	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(3), LIPT1(1)	1808576	4	4	4	1	0	0	0	2	2	0	0.815	0.265	1.000
46	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	B2M(3), HLA-A(6), IL18(1), ITGB1(6), KLRC1(2), KLRC2(3), KLRC3(2), MAPK3(3), PAK1(4), PIK3CA(16), PIK3R1(5), PTK2B(4), PTPN6(3), SYK(2), VAV1(6)	22107815	66	59	59	9	5	16	6	19	19	1	0.0233	0.267	1.000
47	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(4), AMD1(2), BHMT(5), CBS(1), CTH(2), DNMT1(23), DNMT3A(17), DNMT3B(4), MARS(3), MARS2(3), MAT1A(1), MAT2B(1), MTAP(2), MTFMT(1), MTR(1), TAT(3)	24325326	73	66	54	10	6	5	9	16	37	0	0.171	0.307	1.000
48	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(2), EPHX2(2), RDH11(4), RDH12(3), RDH13(1)	5560033	12	12	12	1	1	1	1	8	1	0	0.203	0.315	1.000
49	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(7), EGF(5), EGFR(10), HGS(4), RAB5A(1), TF(1), TFRC(4)	15072760	32	31	30	3	5	1	6	9	11	0	0.0661	0.317	1.000
50	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	AKT1(1), EIF4A1(1), EIF4A2(6), EIF4B(4), EIF4E(2), EIF4G1(9), EIF4G2(4), EIF4G3(7), MKNK1(2), PDK2(4), PIK3CA(16), PIK3R1(5), PPP2CA(1), PTEN(35), RPS6KB1(2), TSC1(5), TSC2(14)	32919216	118	106	110	18	8	19	12	32	40	7	0.0187	0.327	1.000
51	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	A1BG(1), AKT1(1), AKT2(4), AKT3(2), CDKN2A(4), DAPP1(1), GRB2(3), GSK3A(1), GSK3B(3), IARS(4), IGFBP1(1), INPP5D(2), PDK1(1), PIK3CA(16), PPP1R13B(6), PTEN(35), RPS6KA1(7), RPS6KA3(2), RPS6KB1(2), SFN(1), SHC1(4), SOS1(7), SOS2(7), TEC(5), YWHAB(1)	42224854	121	107	109	16	6	21	13	31	45	5	0.00410	0.339	1.000
52	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM2(1), CAMK1(3), CAMK1G(4), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CAMK4(3), CAMKK1(5), CAMKK2(3), CREB1(1), SYT1(1)	13707613	29	29	28	3	3	4	4	9	9	0	0.0645	0.350	1.000
53	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(4), BHMT(5), CBS(1), CTH(2), DNMT1(23), DNMT3A(17), DNMT3B(4), MARS(3), MARS2(3), MAT1A(1), MAT2B(1), MTR(1)	20371255	65	59	46	7	3	4	7	14	37	0	0.135	0.371	1.000
54	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	25	ABL1(6), ATM(23), ATR(11), CCNA1(7), CCNE1(1), CDC25A(2), CDK2(2), CDK4(7), CDK6(1), CDKN1A(3), CDKN1B(1), CDKN2A(4), E2F1(1), GSK3B(3), HDAC1(2), RB1(4), SKP2(2), TGFB2(2), TP53(50)	35461208	132	101	114	21	8	15	15	33	54	7	0.0102	0.374	1.000
55	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3E(1), CD3G(2)	1381597	3	3	3	0	0	0	1	1	1	0	0.585	0.387	1.000
56	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	AKR1A1(1), ECHS1(3), EHHADH(6), HADH(1), HADHA(4), HSD17B4(1), NTAN1(1), SIRT1(5), SIRT5(1), SIRT7(5), VNN2(1)	14034028	29	28	28	3	4	5	7	6	7	0	0.0224	0.424	1.000
57	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	AKR1B10(2), DHRS2(1), DHRSX(5), PON1(1), PON2(2), PON3(5), RDH11(4), RDH12(3), RDH13(1)	10478074	24	23	19	2	2	1	3	10	8	0	0.181	0.431	1.000
58	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	AKT1(1), EIF4A1(1), EIF4A2(6), EIF4E(2), EIF4G1(9), EIF4G2(4), EIF4G3(7), GHR(1), IRS1(6), MAPK1(1), MAPK14(2), MAPK3(3), MKNK1(2), PABPC1(17), PDK2(4), PIK3CA(16), PIK3R1(5), PRKCA(3), PTEN(35), RPS6KB1(2)	33193764	127	108	119	21	13	24	13	34	37	6	0.0170	0.436	1.000
59	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCR3(1), HLA-DRA(1), HLA-DRB1(6), IL3(1)	3309864	9	8	9	2	0	2	2	2	3	0	0.526	0.439	1.000
60	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	CREB1(1), GRB2(3), HRAS(1), PTK2B(4), SHC1(4), SOS1(7), SRC(2)	10246089	22	20	22	2	1	7	1	8	5	0	0.0527	0.457	1.000
61	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD28(1), CD3E(1), CD3G(2), CD80(1), CD86(3), CTLA4(1), GRB2(3), HLA-DRA(1), HLA-DRB1(6), ICOS(3), IL2(1), ITK(2), LCK(1), PIK3CA(16), PIK3R1(5), PTPN11(1)	14919257	48	46	41	7	5	13	3	16	11	0	0.0800	0.495	1.000
62	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(8), CPT1A(3), LEP(1), LEPR(5), PRKAA1(2), PRKAA2(4), PRKAB1(1), PRKAG1(6), PRKAG2(7)	17178441	37	36	34	4	2	5	9	9	12	0	0.0154	0.496	1.000
63	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACAA1(4), ACOX1(2), ACOX3(5), ELOVL2(1), ELOVL5(6), ELOVL6(2), FADS1(1), FADS2(2), FASN(8), HADHA(4), PECR(3)	16829302	38	34	35	4	4	8	4	15	7	0	0.00819	0.501	1.000
64	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(2), IFNG(2), IL18(1), IL2(1)	3598832	6	6	6	1	0	1	0	3	2	0	0.706	0.504	1.000
65	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(10), CS(3), MDH1(1), ME1(1), PC(8), PDHA1(1), SLC25A11(4)	10818832	28	27	28	4	2	3	1	13	9	0	0.155	0.517	1.000
66	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(9), AGT(4), AGTR1(2), AGTR2(1), BDKRB2(1), KNG1(5), NOS3(3), REN(1)	11439822	26	25	24	3	3	3	3	10	7	0	0.0826	0.522	1.000
67	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(1)	855604	1	1	1	0	0	0	1	0	0	0	0.752	0.528	1.000
68	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	AKT1(1), CCNE1(1), CDK2(2), CDK4(7), CDK6(1), CDKN1A(3), CDKN1B(1), E2F1(1), HRAS(1), MAPK1(1), MAPK3(3), NFKB1(1), NFKBIA(1), PAK1(4), PIK3CA(16), PIK3R1(5), RAF1(5), RB1(4), RELA(7)	23847913	65	56	53	8	5	12	7	16	21	4	0.0358	0.557	1.000
69	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(5), BMPR1A(2), BMPR1B(1), BMPR2(6)	7309172	14	12	14	0	0	2	3	6	3	0	0.0140	0.574	1.000
70	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(1), CDK2(2), CDKN1B(1), CUL1(5), E2F1(1), NEDD8(2), RB1(4), RBX1(1), SKP2(2)	10223639	19	19	18	2	1	1	2	4	9	2	0.254	0.610	1.000
71	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(6), ENO2(2), ENO3(2), GOT1(3), GOT2(3), PAH(5), TAT(3), YARS(1)	9835583	25	22	25	4	3	3	5	5	9	0	0.183	0.617	1.000
72	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	ANP32A(3), APEX1(1), CREBBP(13), DFFA(1), DFFB(1), HMGB2(3), PRF1(1)	12367922	23	22	23	3	4	3	7	4	5	0	0.0449	0.618	1.000
73	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNH(1), CDC25A(2), CDC25B(1), CDC25C(4), MNAT1(1), SHH(3), XPO1(7)	10285303	19	19	19	3	2	2	7	6	2	0	0.142	0.638	1.000
74	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ECHS1(3), HADH(1), HADHA(4), HADHB(4), HSD17B4(1), MECR(4), PPT1(1)	10002336	18	17	18	2	2	3	5	7	1	0	0.0854	0.654	1.000
75	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(7), CCNE1(1), CDK2(2), CUL1(5), E2F1(1), RB1(4), SKP2(2)	10290722	22	22	19	3	1	2	2	4	11	2	0.240	0.655	1.000
76	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(2), GNAS(5), GNB1(3), PPP2CA(1), PRKAA1(2), PRKAA2(4), PRKAB1(1), PRKACB(2), PRKACG(3), PRKAG1(6), PRKAG2(7), PRKAR1A(3), PRKAR2B(4)	17918241	43	41	40	5	4	4	5	16	14	0	0.0392	0.677	1.000
77	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(7), FOS(1), GRB2(3), HRAS(1), IL3(1), JAK2(7), MAPK3(3), PTPN6(3), RAF1(5), SHC1(4), SOS1(7), STAT5A(4), STAT5B(4)	20797857	50	47	49	6	6	4	8	19	13	0	0.0376	0.694	1.000
78	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(2), CDC25B(1), CDKN1A(3), CHEK1(1), NEK1(4), WEE1(2)	8729131	13	12	13	1	1	2	0	6	3	1	0.226	0.701	1.000
79	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(1), HMGCL(2), OXCT1(2)	4036194	5	5	5	1	0	1	0	2	2	0	0.588	0.703	1.000
80	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(1), ALDOA(2), ALDOB(5), TPI1(1)	4573571	9	9	8	4	0	0	2	1	6	0	0.979	0.703	1.000
81	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	CBL(2), EGF(5), EGFR(10), GRB2(3), HRAS(1), MAPK1(1), MAPK3(3), PTPRB(7), RAF1(5), RASA1(7), SHC1(4), SOS1(7), SPRY1(2), SPRY2(3), SPRY4(10), SRC(2)	29507404	72	63	63	8	6	15	10	19	22	0	0.00691	0.707	1.000
82	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BAG4(1), BIRC3(6), CASP8(1), RIPK1(2), TNF(1), TNFRSF1A(1), TNFRSF1B(2), TRADD(2), TRAF2(1)	9529683	17	17	17	3	0	4	5	6	2	0	0.270	0.714	1.000
83	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(5), ENO1(6), GPI(3), HK1(7), PFKL(3), PGK1(3), PKLR(1), TPI1(1)	10653480	29	28	26	5	5	3	2	6	13	0	0.212	0.715	1.000
84	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(2), CD28(1), CD3E(1), CD3G(2), CD4(10), ICAM1(3), ITGAL(6), ITGB2(2), PTPRC(7), THY1(1)	13179950	35	32	29	5	1	4	3	12	14	1	0.380	0.720	1.000
85	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(3), ALPL(4), ALPP(4), ALPPL2(5), FPGS(4), GGH(3)	7426369	23	21	23	6	4	5	3	7	4	0	0.269	0.721	1.000
86	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	HLCS(2), SPCS1(2), SPCS3(1)	3645746	5	5	5	1	0	0	1	2	2	0	0.669	0.729	1.000
87	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3E(1), CD3G(2), CD4(10), FYN(2), HLA-DRA(1), HLA-DRB1(6), LCK(1), PTPRC(7), ZAP70(1)	10388157	31	29	25	5	1	4	2	11	12	1	0.499	0.740	1.000
88	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(2), CD28(1), CD3E(1), CD3G(2), CD8A(1), ICAM1(3), ITGAL(6), ITGB2(2), PTPRC(7), THY1(1)	12471261	26	24	26	4	1	4	3	11	7	0	0.255	0.745	1.000
89	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(6), CTH(2), GOT1(3), GOT2(3), LDHB(1), LDHC(3), MPST(2)	7991957	20	20	18	4	1	0	2	6	11	0	0.710	0.745	1.000
90	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(1), CCL2(1), LDLR(4), LPL(6)	6181145	12	12	12	3	1	3	0	4	4	0	0.474	0.749	1.000
91	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(1), TPI1(1)	1923861	2	2	2	1	0	0	1	1	0	0	0.874	0.754	1.000
92	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(7), CCNA2(1), CCNE1(1), CCNE2(4), CDK2(2), CDK4(7), CDKN1B(1), CDKN2A(4), E2F1(1), E2F2(1), PRB1(6)	10411345	35	28	23	7	0	3	4	3	25	0	0.605	0.755	1.000
93	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	22	ATM(23), ATR(11), BRCA1(8), CDC25A(2), CDC25B(1), CDC25C(4), CDKN1A(3), CHEK1(1), CHEK2(3), EP300(16), MYT1(9), PRKDC(10), RPS6KA1(7), TP53(50), WEE1(2)	50594176	150	119	133	22	9	22	16	48	49	6	0.00274	0.755	1.000
94	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(2)	1942941	2	2	2	0	0	0	0	2	0	0	0.702	0.764	1.000
95	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(3), ICAM1(3), ITGAL(6), ITGAM(9), ITGB2(2), SELE(5), SELL(2)	12488509	30	30	30	5	0	9	5	9	7	0	0.0961	0.766	1.000
96	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	FOSB(1), GRIA2(5), PPP1R1B(1)	4332827	7	7	7	2	1	1	1	3	1	0	0.596	0.774	1.000
97	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	HRAS(1), MMP14(1), MMP2(6), MMP9(1), RECK(3), TIMP1(1), TIMP2(1), TIMP3(4)	8871265	18	17	15	3	2	2	1	6	7	0	0.484	0.776	1.000
98	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	CASP8(1), CFL1(1), CFLAR(3)	4537325	5	5	5	1	0	0	3	1	1	0	0.588	0.779	1.000
99	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(2), IFNGR1(3), IFNGR2(2), JAK1(6), JAK2(7), STAT1(6)	9770238	26	26	26	5	3	0	3	11	9	0	0.495	0.785	1.000
100	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCR3(1), CD4(10), HLA-DRA(1), HLA-DRB1(6), IL1B(1), IL4(1), IL5RA(1)	6093775	21	20	15	5	0	4	3	3	10	1	0.800	0.803	1.000
101	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	ALDOA(2), CTSD(2), GREB1(18), HSPB2(3), MTA1(7), MTA3(4), PDZK1(1), TUBA8(1)	12679545	38	35	36	8	1	5	9	15	8	0	0.355	0.803	1.000
102	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(6), CYP2E1(1), NR1I3(1), PTGS1(2), PTGS2(5)	6209152	15	15	15	4	2	2	1	6	3	1	0.585	0.811	1.000
103	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	CASP7(1), DFFA(1), DFFB(1), HMGB1(2), HMGB2(3), TOP2A(5), TOP2B(3)	11885764	16	15	16	1	3	2	2	3	5	1	0.116	0.814	1.000
104	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	NRF1(1), UBE2A(2), UBE2D1(2), UBE2D2(1), UBE2D3(2), UBE2H(2), UBE2I(1), UBE2J1(1), UBE2J2(1), UBE2L3(1), UBE3A(4)	12356359	18	18	18	2	2	2	2	8	4	0	0.159	0.822	1.000
105	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CCNE1(1), CDK2(2), CUL1(5), E2F1(1), FBXW7(5), RB1(4)	9994649	18	18	18	3	1	1	3	3	8	2	0.423	0.831	1.000
106	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(2), HPRT1(1), IMPDH1(1), MTHFD2(2), POLB(2), POLD1(8), POLG(6), PRPS2(4), RRM1(4)	14678780	30	29	28	4	2	5	2	10	11	0	0.118	0.836	1.000
107	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	ASRGL1(4), GBA(2), GGT1(4), SHMT1(4), SHMT2(6)	6529229	20	20	17	5	2	1	3	5	9	0	0.493	0.857	1.000
108	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(1), HGD(2)	2655701	3	3	3	1	0	0	1	0	2	0	0.902	0.866	1.000
109	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(1), CYP2C9(1)	2388047	2	2	2	1	0	0	0	1	1	0	0.774	0.872	1.000
110	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(2), GNAS(5), GNB1(3), PRKACA(1), PRKAR1A(3)	7532310	14	14	14	3	1	1	1	10	1	0	0.646	0.878	1.000
111	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	CSNK2A1(3), ELK1(2), FOS(1), GRB2(3), HRAS(1), INS(1), INSR(4), IRS1(6), JUN(2), MAPK3(3), PIK3CA(16), PIK3R1(5), PTPN11(1), RAF1(5), RASA1(7), SHC1(4), SLC2A4(3), SOS1(7)	29475076	74	69	66	11	10	20	8	24	12	0	0.00801	0.887	1.000
112	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	65	APAF1(4), ATM(23), ATR(11), BAI1(4), BAX(1), BID(2), CASP8(1), CASP9(2), CCNB2(6), CCNB3(4), CCND2(1), CCND3(1), CCNE1(1), CCNE2(4), CCNG2(2), CD82(3), CDK2(2), CDK4(7), CDK6(1), CDKN1A(3), CDKN2A(4), CHEK1(1), CHEK2(3), FAS(2), GADD45B(2), GTSE1(4), IGFBP3(1), PERP(1), PPM1D(2), PTEN(35), RCHY1(3), RFWD2(4), RRM2(1), SERPINB5(4), SESN1(3), SFN(1), STEAP3(2), THBS1(16), TNFRSF10B(1), TP53(50), TP53I3(4), TP73(4), TSC2(14), ZMAT3(1)	76509917	246	185	228	34	21	32	32	58	93	10	2.63e-05	0.889	1.000
113	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(5), SUCLA2(2)	2459780	7	7	7	3	0	2	1	2	2	0	0.875	0.890	1.000
114	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	B3GNT1(2), FUT2(1), GCNT2(5), ST8SIA1(2)	7006778	10	10	10	2	2	1	1	5	1	0	0.352	0.891	1.000
115	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(10), CD8A(1), IL2(1), IL3(1), IL4(1), IL9(1)	7132019	15	15	9	3	0	2	2	2	8	1	0.786	0.894	1.000
116	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GSR(2), GSS(1), NFKB1(1), NOX1(7), RELA(7), TNF(1), XDH(7)	11669608	26	23	21	4	1	2	6	4	12	1	0.490	0.903	1.000
117	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(7), AMT(1), ATIC(3), GART(4), MTHFD1(7), MTHFD1L(4), MTHFD2(2), MTHFR(2), MTR(1), SHMT1(4), SHMT2(6)	21171181	41	40	41	6	4	7	5	16	9	0	0.0473	0.910	1.000
118	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG12(1), ATG3(1), ATG7(7), BECN1(2), IFNA1(1), IFNA14(1), IFNA16(1), IFNA2(2), IFNA21(3), IFNA5(1), IFNA7(3), IFNA8(2), IFNG(2), INS(1), PIK3C3(4), PIK3R4(5), PRKAA1(2), PRKAA2(4), ULK1(2), ULK2(3), ULK3(4)	24987471	52	49	49	7	4	3	4	27	14	0	0.0919	0.912	1.000
119	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP5E(1), ATP6AP1(4), ATP6V0A1(5), ATP6V0A4(3), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(5), ATP6V1B1(4), ATP6V1B2(5), ATP6V1C1(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1G1(1), ATP6V1H(1), FDXR(3), SHMT1(4)	18945268	42	40	42	7	3	3	11	15	9	1	0.153	0.912	1.000
120	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(2), AASDH(6), AASDHPPT(3), AASS(9), ACAT1(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(4), ALDH1B1(3), ALDH2(4), ALDH3A2(3), BBOX1(1), DOT1L(8), ECHS1(3), EHHADH(6), EHMT1(4), EHMT2(8), GCDH(5), HADHA(4), PLOD1(3), PLOD2(7), PLOD3(12), SHMT1(4), SHMT2(6), TMLHE(1)	42557587	109	91	97	16	10	17	16	31	34	1	0.00631	0.912	1.000
121	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(3), ACADM(3), ACADS(3), ACSL1(2), ACSL3(13), ACSL4(1), CPT1A(3), CPT2(2), EHHADH(6), HADHA(4), PECR(3), SCP2(3)	19867739	46	42	34	8	2	9	10	20	5	0	0.0380	0.913	1.000
122	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(2), CSAD(3), GAD1(2), GAD2(3), GGT1(4)	6718975	14	14	14	4	1	1	5	3	4	0	0.506	0.916	1.000
123	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(10), ACO1(5), ACSS1(3), ACSS2(8), FH(2), IDH1(2), IDH2(6), MDH1(1), MDH2(1), SUCLA2(2)	15749565	40	33	36	7	2	6	3	11	17	1	0.229	0.917	1.000
124	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	DCN(3), FMOD(3), KERA(2), LUM(1)	4205580	9	9	9	3	0	1	0	5	3	0	0.674	0.920	1.000
125	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(2), IFNG(2), IFNGR1(3), JAK1(6), JAK2(7), PTPRU(6), STAT1(6)	13450707	32	30	32	6	4	0	3	17	8	0	0.435	0.924	1.000
126	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	MTMR1(2), MTMR2(3), MTMR6(1), NFS1(1), PHPT1(1), THTPA(1), TPK1(1)	7567533	10	10	10	2	1	1	2	6	0	0	0.431	0.929	1.000
127	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(5), FH(2), IDH1(2), IDH2(6), MDH1(1), MDH2(1), SDHB(1), SUCLA2(2)	10577915	20	19	17	4	1	3	1	6	9	0	0.404	0.935	1.000
128	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(6), GABBR1(6), GPRC5A(2), GPRC5B(2), GPRC5C(2), GPRC5D(1), GRM1(5), GRM2(3), GRM3(7), GRM4(5), GRM5(8), GRM7(5), GRM8(3)	23436178	55	48	52	9	7	8	6	23	11	0	0.0741	0.941	1.000
129	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	CYP51A1(2), DHCR7(3), FDFT1(2), FDPS(1), HMGCR(1), HMGCS1(4), IDI1(1), LSS(4), MVK(1), NSDHL(3), PMVK(1)	15535886	23	21	23	2	0	3	3	10	7	0	0.0972	0.941	1.000
130	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(3), GUSB(5), RPE(2), UCHL1(1), UCHL3(1), UGDH(1), UGT1A1(5), UGT1A10(1), UGT1A3(2), UGT1A4(3), UGT1A5(4), UGT1A6(5), UGT1A7(4), UGT1A9(6), UGT2B15(1), UGT2B4(4)	20706338	48	44	48	9	3	7	12	12	14	0	0.176	0.942	1.000
131	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(5), EGFR(10), ERBB3(7), NRG1(4), UBE2D1(2)	12128567	28	28	26	5	4	2	3	9	10	0	0.258	0.942	1.000
132	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(4), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ALDH7A1(1), MIOX(2), UGDH(1)	10015588	18	18	16	4	2	2	3	4	7	0	0.542	0.943	1.000
133	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(1), BDH1(1), BDH2(1), HMGCL(2), HMGCS1(4), HMGCS2(3), OXCT1(2)	8734560	14	14	14	3	0	2	1	6	5	0	0.542	0.943	1.000
134	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	C9orf47(1), CNR1(1), CNR2(3), DNMT1(23), MTNR1B(1), PTAFR(1), PTGDR(1), PTGER2(1), PTGER4(1), PTGFR(5), PTGIR(1), TBXA2R(4)	12598356	43	40	28	9	2	4	6	10	21	0	0.620	0.945	1.000
135	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(1), F2(4), F2R(2), F5(11), F7(1), FGA(4), FGB(3), FGG(6), PROC(3), PROS1(5), TFPI(1)	19277211	41	39	39	7	6	3	3	14	14	1	0.168	0.946	1.000
136	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(6), ABCB11(4), ABCB4(7), ABCC1(11), ABCC3(10)	17163435	38	32	32	6	2	7	7	10	12	0	0.117	0.946	1.000
137	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(5), CS(3), DLD(4), FH(2), IDH1(2), IDH2(6), IDH3B(2), IDH3G(2), MDH1(1), MDH2(1), PC(8), PCK1(9), SDHA(8), SDHB(1), SUCLA2(2), SUCLG1(6), SUCLG2(2)	24274091	64	58	61	12	3	9	9	21	21	1	0.132	0.947	1.000
138	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREB1(1), CREM(1), FOS(1), JUN(2), MAPK3(3), OPRK1(2), POLR2A(11), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4)	14986154	33	32	33	6	8	3	5	10	7	0	0.0967	0.948	1.000
139	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(1), IARS(4), LARS(7), LARS2(2), PDHA1(1), PDHA2(3), PDHB(1)	11899140	19	17	19	3	2	3	3	5	6	0	0.251	0.949	1.000
140	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(2), CHRNA1(2), STX1A(1), VAMP2(1)	3774022	6	5	6	3	0	1	0	2	3	0	0.920	0.954	1.000
141	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5E(1), ATP6AP1(4), ATP6V0A1(5), ATP6V0A4(3), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(5), ATP6V1B1(4), ATP6V1B2(5), ATP6V1C1(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1G1(1), ATP6V1H(1), SHMT1(4)	17916958	39	37	39	7	3	2	11	13	9	1	0.221	0.957	1.000
142	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5E(1), ATP6AP1(4), ATP6V0A1(5), ATP6V0A4(3), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(5), ATP6V1B1(4), ATP6V1B2(5), ATP6V1C1(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1G1(1), ATP6V1H(1), SHMT1(4)	17916958	39	37	39	7	3	2	11	13	9	1	0.221	0.957	1.000
143	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5E(1), ATP6AP1(4), ATP6V0A1(5), ATP6V0A4(3), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(5), ATP6V1B1(4), ATP6V1B2(5), ATP6V1C1(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1G1(1), ATP6V1H(1), SHMT1(4)	17916958	39	37	39	7	3	2	11	13	9	1	0.221	0.957	1.000
144	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(1), B3GALNT1(2), B3GALT5(3), FUT2(1), GBGT1(3), GLA(1), HEXA(5), HEXB(1), ST3GAL1(2), ST8SIA1(2)	12352485	21	20	21	4	3	3	2	10	3	0	0.211	0.958	1.000
145	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	CSNK2A1(3), DPM2(1), ELK1(2), FOS(1), GRB2(3), HRAS(1), JUN(2), MAPK3(3), NGFR(2), PIK3CA(16), PIK3R1(5), PLCG1(3), RAF1(5), SHC1(4), SOS1(7)	22157102	58	55	51	10	7	16	6	21	8	0	0.0527	0.961	1.000
146	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	AOC2(5), AOC3(1), CES1(8), ESD(1)	6899681	15	15	13	4	0	3	2	5	5	0	0.502	0.961	1.000
147	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	AKT1(1), CASP9(2), CHUK(2), GHR(1), NFKB1(1), NFKBIA(1), PIK3CA(16), PIK3R1(5), PPP2CA(1), RELA(7)	16942499	37	36	28	6	2	13	1	10	10	1	0.112	0.961	1.000
148	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDK(2), CBS(1), CTH(2), MUT(2)	5726813	7	7	7	2	1	0	1	1	4	0	0.842	0.961	1.000
149	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(3), ICAM1(3), ITGA4(3), ITGAL(6), ITGAM(9), ITGB1(6), ITGB2(2), SELE(5), SELL(2), SELP(2)	19016965	41	39	41	8	0	11	8	12	10	0	0.138	0.963	1.000
150	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	19	ABL1(6), ATM(23), BRCA1(8), CDKN1A(3), CHEK1(1), CHEK2(3), JUN(2), MRE11A(4), NFKB1(1), NFKBIA(1), RAD50(4), RAD51(2), RBBP8(2), RELA(7), TP53(50), TP73(4)	34843173	121	100	108	21	9	16	12	41	37	6	0.0442	0.965	1.000
151	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(3), EXT2(3), EXTL1(2), EXTL2(7), EXTL3(3), GLCE(5), HS2ST1(2), HS3ST1(1), HS3ST2(2), HS3ST3A1(1), HS3ST5(1), HS6ST1(3), HS6ST2(2), HS6ST3(1), NDST1(3), NDST2(4), NDST4(9)	24147806	52	48	46	7	5	9	4	14	20	0	0.0371	0.966	1.000
152	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(3), ICAM1(3), ITGA4(3), ITGAL(6), ITGB1(6), ITGB2(2), SELE(5), SELL(2)	14368468	30	29	30	6	0	9	6	7	8	0	0.197	0.966	1.000
153	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	20	AKT1(1), APAF1(4), ATM(23), BAX(1), BID(2), CASP6(1), CASP7(1), CASP9(2), PRKCA(3), PTK2(3), PXN(3), STAT1(6), TLN1(12), TP53(50)	32301423	112	91	102	20	9	13	10	35	41	4	0.0384	0.967	1.000
154	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(2), F13B(3), HSD17B1(2), HSD17B2(1), HSD17B4(1), HSD3B1(1)	9508316	10	10	10	2	2	3	2	2	1	0	0.328	0.967	1.000
155	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(2), FDPS(1), IDI1(1), IDI2(2)	5140988	6	6	6	2	1	0	0	2	3	0	0.849	0.968	1.000
156	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(1), ACTR2(2), ACTR3(1), ARPC1B(1), ARPC2(8), CDC42(1), WASF1(1), WASL(9)	9604780	24	24	18	5	1	4	2	8	9	0	0.346	0.970	1.000
157	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALT(3), UGDH(1), UXS1(1)	4707481	5	5	5	2	0	1	3	1	0	0	0.717	0.970	1.000
158	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	CREB1(1), FOS(1), JUN(2), KEAP1(4), MAPK1(1), MAPK14(2), NFE2L2(13), PRKCA(3)	10367017	27	27	24	7	2	3	3	14	5	0	0.473	0.971	1.000
159	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	35	ACTA1(1), DOCK1(2), ELK1(2), FOS(1), GAB1(1), GRB2(3), HGF(2), HRAS(1), ITGA1(8), ITGB1(6), JUN(2), MAP2K2(1), MAP4K1(3), MAPK1(1), MAPK3(3), MET(28), PAK1(4), PIK3CA(16), PIK3R1(5), PTEN(35), PTK2(3), PTK2B(4), PTPN11(1), PXN(3), RAF1(5), RAP1A(1), RASA1(7), SOS1(7), SRC(2), STAT3(4)	52980361	162	130	145	28	10	36	18	45	49	4	0.0114	0.972	1.000
160	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(1), CR1(11), CR2(4), HLA-DRA(1), HLA-DRB1(6), ICAM1(3), ITGAL(6), ITGB2(2), PTPRC(7)	18530781	41	38	41	8	3	6	3	17	12	0	0.352	0.974	1.000
161	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(1), ACP2(2), ACP5(2), ENPP1(2), ENPP3(2), FLAD1(5), TYR(5)	11396461	19	19	19	4	0	4	0	10	5	0	0.539	0.975	1.000
162	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(1), ALDH1A2(1), RDH5(3)	4531700	5	5	5	2	0	0	2	2	1	0	0.810	0.975	1.000
163	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(4), CBS(1), CTH(2), GGT1(4), MARS(3), MARS2(3), MAT1A(1), MAT2B(1), PAPSS1(3), PAPSS2(4), SCLY(3), SEPHS1(1)	14397996	30	29	30	6	3	3	7	8	9	0	0.300	0.976	1.000
164	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(3), ERBB4(11), NRG2(3), NRG3(5), PRKCA(3), PSEN1(1)	10732996	26	26	26	6	2	5	3	11	5	0	0.398	0.976	1.000
165	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(4), LDLR(4), MBTPS1(4), MBTPS2(2), SCAP(3), SREBF1(4), SREBF2(11)	13962967	32	32	32	7	3	4	6	8	11	0	0.336	0.977	1.000
166	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(4), ARHGAP5(5), ARHGDIB(1), CASP1(2), CASP10(3), CASP8(1), CASP9(2), JUN(2), PRF1(1)	14949157	21	20	21	3	0	4	1	7	9	0	0.367	0.977	1.000
167	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CDC25A(2), CDC25B(1), CDC25C(4), CSK(4), GRB2(3), PRKCA(3), PTPRA(5), SRC(2)	10889531	24	22	24	5	1	7	4	8	4	0	0.228	0.977	1.000
168	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALT(3), UGDH(1), UGP2(1), UXS1(1)	5951897	6	6	6	2	0	1	4	1	0	0	0.603	0.978	1.000
169	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(3), FDFT1(2), FDPS(1), HMGCR(1), IDI1(1), LSS(4), MVK(1), NQO2(1), PMVK(1), VKORC1(1)	13028401	16	16	16	2	0	1	3	7	5	0	0.258	0.978	1.000
170	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(6), F13A1(3), F2(4), F2R(2), FGA(4), FGB(3), FGG(6), PLAT(4), PLG(6)	15878389	38	35	33	8	6	2	5	14	11	0	0.275	0.978	1.000
171	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(4), DYRK1B(1), GLI2(4), GLI3(7), GSK3B(3), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4), SHH(3), SMO(5), SUFU(3)	18844457	42	40	40	8	5	6	5	15	11	0	0.154	0.979	1.000
172	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	ATF1(2), BRAF(6), CREB1(1), CREB5(3), DUSP4(1), DUSP6(2), DUSP9(2), EEF2K(2), EIF4E(2), GRB2(3), MAP2K2(1), MAP3K8(1), MAPK1(1), MAPK3(3), MKNK1(2), MKNK2(2), MOS(1), NFKB1(1), RAP1A(1), RPS6KA1(7), RPS6KA3(2), SHC1(4), SOS1(7), SOS2(7), TRAF3(1)	34868707	65	62	60	9	7	10	11	21	14	2	0.0211	0.979	1.000
173	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	CS(3), FH(2), IDH2(6), MDH1(1), OGDH(8), SDHA(8), SUCLA2(2)	11153169	30	27	27	7	1	8	0	11	10	0	0.411	0.980	1.000
174	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	42	APAF1(4), BAX(1), BID(2), BIRC2(3), BIRC3(6), CASP2(1), CASP6(1), CASP7(1), CASP8(1), CASP9(2), FAS(2), FASLG(2), JUN(2), MAP3K1(8), MAPK10(2), MCL1(1), MYC(1), NFKB1(1), NFKBIA(1), PARP1(6), PRF1(1), RELA(7), RIPK1(2), TNF(1), TNFRSF1A(1), TNFRSF1B(2), TNFSF10(9), TP53(50), TRADD(2), TRAF2(1)	43916675	124	101	109	22	5	18	16	40	40	5	0.0251	0.980	1.000
175	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(1), CAT(3), EPX(2), LPO(2), MPO(5), MTHFR(2), PRDX6(2), SHMT1(4), SHMT2(6), TPO(4)	13574663	31	30	31	6	1	3	7	11	9	0	0.297	0.982	1.000
176	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	ADRB2(2), AKT1(1), ANXA1(1), CALM2(1), GNAS(5), GNB1(3), NFKB1(1), NOS3(3), NPPA(1), NR3C1(4), PIK3CA(16), PIK3R1(5), RELA(7), SYT1(1)	20939722	51	48	42	9	5	15	2	16	12	1	0.170	0.982	1.000
177	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(2), DAG1(3), ITPKA(1), ITPKB(3)	6806857	9	8	9	4	1	1	2	0	5	0	0.915	0.983	1.000
178	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CCL3(1), FLT3(7), IL3(1), IL9(1), KITLG(2), TGFB2(2)	9890437	14	14	14	3	0	1	3	5	5	0	0.623	0.984	1.000
179	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(1), CHAT(5), PCYT1A(2), PDHA1(1), PDHA2(3), SLC18A3(2)	7827104	14	14	12	4	2	2	1	3	6	0	0.723	0.984	1.000
180	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(23), CDC25A(2), CDC25B(1), CDC25C(4), CHEK1(1), MYT1(9), WEE1(2)	16378588	42	38	41	9	3	10	5	14	10	0	0.228	0.984	1.000
181	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYA(3), NFYC(3), RB1(4), SP1(2), SP3(3)	7958528	15	15	15	5	0	3	1	4	5	2	0.843	0.984	1.000
182	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(1), ALDH1A2(1), ALDH1A3(4), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ECHS1(3), EHHADH(6), HADHA(4)	14332042	29	29	26	6	3	4	7	8	7	0	0.239	0.985	1.000
183	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP1(1), ACP2(2), ACP5(2), ACP6(1), ALPI(3), ALPL(4), ALPP(4), ALPPL2(5), CMBL(3), CYP3A43(2), CYP3A5(1), CYP3A7(2), DHRS2(1), DHRSX(5), PON1(1), PON2(2), PON3(5)	21016279	44	42	39	8	4	7	3	14	16	0	0.263	0.985	1.000
184	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(7), AMT(1), ATIC(3), FTCD(3), GART(4), MTFMT(1), MTHFD1(7), MTHFD1L(4), MTHFD2(2), MTHFR(2), MTR(1), SHMT1(4), SHMT2(6)	22501622	45	44	45	9	4	7	5	20	9	0	0.180	0.985	1.000
185	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(2), GAD1(2), HDC(1), TH(4), TPH1(3)	6893106	12	12	12	4	2	2	4	2	2	0	0.633	0.985	1.000
186	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	9	BPNT1(3), PAPSS1(3), PAPSS2(4), SULT2A1(1), SUOX(5)	8504618	16	15	16	4	1	1	4	3	7	0	0.601	0.986	1.000
187	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(9), C5(7), C6(3), C7(4), C8A(3), C9(1)	15081835	27	27	27	5	2	5	3	13	4	0	0.219	0.986	1.000
188	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	16	C1QA(1), C1R(4), C1S(16), C2(5), C3(9), C4A(1), C5(7), C6(3), C7(4), C8A(3), C9(1), MASP1(5), MASP2(2), MBL2(2)	32887906	63	54	48	8	6	10	5	26	15	1	0.0136	0.986	1.000
189	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(1), EPHA4(3), EPHB1(3), FYN(2), ITGA1(8), ITGB1(6), L1CAM(5), LYN(3), SELP(2)	18462940	33	31	32	5	4	4	2	13	10	0	0.164	0.987	1.000
190	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(1), GALNS(6), GLB1(5), GNS(3), GUSB(5), HEXA(5), HEXB(1), IDS(2), IDUA(2), LCT(5), NAGLU(3)	16997409	38	33	38	8	4	6	5	11	12	0	0.199	0.987	1.000
191	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(1), CYP11A1(2), CYP11B2(2), CYP17A1(2), HSD11B1(1), HSD11B2(1), HSD3B1(1)	7999811	10	10	10	3	1	0	1	7	1	0	0.614	0.987	1.000
192	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCNA1(7), CCND2(1), CCND3(1), CCNE1(1), CCNH(1), CDC25A(2), CDK2(2), CDK4(7), CDK6(1), CDKN1A(3), CDKN1B(1), CDKN2A(4), CDKN2C(1), E2F1(1), RB1(4)	18790173	37	33	31	9	2	1	4	7	20	3	0.623	0.987	1.000
193	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(5), CYP51A1(2), DHCR24(1), DHCR7(3), FDFT1(2), FDPS(1), GGCX(2), HMGCR(1), IDI1(1), IDI2(2), LSS(4), MVK(1), NSDHL(3), PMVK(1), TM7SF2(3), VKORC1(1)	22729691	33	31	31	3	1	3	2	15	12	0	0.0856	0.988	1.000
194	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(1), LPL(6), NR3C1(4), PPARG(3), RETN(1), RXRA(2), TNF(1)	6617286	18	17	18	6	2	6	1	3	6	0	0.637	0.988	1.000
195	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	NFKB1(1), NFKBIA(1), PLCB1(3), PRKCA(3), RELA(7)	9734433	15	15	12	7	1	3	0	1	9	1	0.978	0.988	1.000
196	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(2), FDPS(1), IDI1(1)	3860292	4	4	4	2	0	0	0	2	2	0	0.955	0.989	1.000
197	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(5), ALOX15B(4), ALOX5(4), DPEP1(2), GGT1(4), LTA4H(4), PLA2G6(5), PTGDS(1), PTGES(1), PTGS1(2), PTGS2(5), TBXAS1(4)	17900650	41	37	39	8	5	5	8	11	11	1	0.200	0.989	1.000
198	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA1(1), NDUFA10(1), NDUFB2(1), NDUFB4(2), NDUFB5(2), NDUFB6(1), NDUFB7(1), NDUFS1(8), NDUFS2(1), NDUFV1(2), NDUFV2(1)	8292640	21	21	21	6	0	1	3	10	7	0	0.720	0.990	1.000
199	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(3), IL4(1), JUNB(2), MAF(1), MAP2K3(3), MAPK14(2), NFATC1(4), NFATC2(6), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4)	13579389	34	32	32	8	6	1	3	13	11	0	0.398	0.991	1.000
200	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(1), CD3E(1), CD3G(2), IFNG(2), IL2(1), IL2RA(2), IL4(1), TGFB2(2), TGFBR1(1), TGFBR2(1), TGFBR3(3), TOB1(4), TOB2(3)	12598947	24	24	24	5	1	2	6	8	7	0	0.352	0.991	1.000
201	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(10), POLR1B(4), POLR1C(2), POLR1D(1), POLR2A(11), POLR2B(6), POLR2C(1), POLR2D(1), POLR2F(4), POLR2I(1), POLR2K(1), POLR3A(7), POLR3B(3), POLR3G(2), POLR3GL(1), POLR3H(2), POLR3K(1)	27630715	58	53	56	9	4	9	5	22	18	0	0.0652	0.992	1.000
202	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	DHRS2(1), DHRSX(5), LCMT1(1), LCMT2(4), METTL2B(1), PRMT2(1), PRMT3(2), PRMT5(5), PRMT6(2), PRMT7(3), PRMT8(3)	17396623	28	25	24	3	1	2	6	8	11	0	0.189	0.992	1.000
203	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	15	C1QA(1), C1R(4), C1S(16), C2(5), C3(9), C4A(1), C5(7), C6(3), C7(4), C8A(3), C8B(2), C9(1), MASP1(5)	32216097	61	52	46	8	7	9	4	25	15	1	0.0201	0.993	1.000
204	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(1), CAT(3), EPX(2), LPO(2), MPO(5), PRDX1(1), PRDX5(2), PRDX6(2), SHMT1(4), SHMT2(6), TPO(4)	13835971	32	31	32	7	1	4	7	11	9	0	0.346	0.993	1.000
205	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	13	C1QA(1), C1R(4), C1S(16), C2(5), C3(9), C4A(1), C5(7), C6(3), C7(4), C8A(3), C9(1)	28320458	54	45	39	7	4	8	4	23	14	1	0.0327	0.993	1.000
206	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	PLCD1(3), PRKCA(3)	5762026	6	6	6	2	0	1	0	1	4	0	0.914	0.994	1.000
207	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA3(2), PSMA4(2), PSMA6(4), PSMA7(1), PSMB1(1), PSMB4(1), PSMB5(2), PSMB6(1), PSMB7(1), PSMC3(1), RPN1(4), RPN2(2), UBE2A(2), UBE3A(4)	15582305	28	28	28	5	1	2	3	14	8	0	0.440	0.994	1.000
208	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA3(2), PSMA4(2), PSMA6(4), PSMA7(1), PSMB1(1), PSMB10(1), PSMB4(1), PSMB5(2), PSMB6(1), PSMB7(1)	10116055	16	16	16	4	0	1	1	9	5	0	0.798	0.994	1.000
209	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	FUT2(1), FUT3(2), FUT5(1), FUT6(4), ST3GAL3(3)	5583180	11	10	9	4	4	2	0	2	3	0	0.708	0.994	1.000
210	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	DPM2(1), EGR1(10), HRAS(1), MAP2K2(1), MAPK1(1), MAPK3(3), NGFR(2), RAF1(5)	9540427	24	24	17	6	4	1	2	8	9	0	0.702	0.994	1.000
211	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNA1(1), IFNAR1(3), IFNB1(2), JAK1(6), STAT1(6), STAT2(7), TYK2(7)	12734329	32	27	31	8	4	5	4	7	12	0	0.328	0.995	1.000
212	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(2), MAPK14(2), NFKB1(1), RELA(7), TNFRSF13B(1), TNFSF13(1), TRAF2(1), TRAF3(1), TRAF5(4), TRAF6(2)	17056100	22	21	19	3	0	5	0	7	9	1	0.368	0.995	1.000
213	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(4), POLR2A(11), POLR2B(6), POLR2C(1), POLR2D(1), POLR2F(4), POLR2I(1), POLR2K(1), POLRMT(5)	15575333	34	33	32	7	2	4	6	9	13	0	0.331	0.996	1.000
214	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(20), MAP2(5), PPP2CA(1), PRKACB(2), PRKACG(3), PRKAG1(6), PRKAR2B(4), PRKCE(4)	21093846	45	41	42	8	5	4	4	16	15	1	0.179	0.996	1.000
215	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	DPM2(1), EGFR(10), ELK1(2), GNAS(5), GNB1(3), GRB2(3), HRAS(1), IGF1R(4), ITGB1(6), MAP2K2(1), MAPK1(1), MAPK3(3), MKNK1(2), MKNK2(2), MYC(1), NGFR(2), PDGFRA(6), PPP2CA(1), PTPRR(6), RAF1(5), RPS6KA1(7), RPS6KA5(3), SHC1(4), SOS1(7), SRC(2), STAT3(4)	38822999	92	79	86	16	10	19	8	31	23	1	0.0447	0.996	1.000
216	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(2), ADH1B(2), ADH4(1), ADH6(3), ADHFE1(3)	6673482	11	11	10	5	1	0	0	7	3	0	0.931	0.996	1.000
217	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(8), CD38(1), ENPP1(2), ENPP3(2), NADSYN1(1), NMNAT2(3), NNMT(1), NNT(9), NT5C(1), NT5M(3), QPRT(1)	17203425	32	32	32	7	3	4	3	17	5	0	0.330	0.996	1.000
218	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(2), CDKN1A(3), EPOR(1), GRIN1(2), HIF1A(5), JAK2(7), NFKB1(1), NFKBIA(1), RELA(7)	14984819	29	27	26	6	0	4	4	8	10	3	0.519	0.996	1.000
219	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(2), LPO(2), MPO(5), PRDX1(1), PRDX5(2), PRDX6(2), TPO(4), TYR(5)	11339263	23	22	23	5	0	3	5	8	7	0	0.439	0.996	1.000
220	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	12	AKT1(1), CAT(3), GHR(1), HRAS(1), IGF1R(4), PIK3CA(16), PIK3R1(5), SHC1(4)	15346092	35	32	29	8	4	10	2	13	6	0	0.277	0.996	1.000
221	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(2), POLD1(8), POLD2(1), POLE(6), POLG(6), POLL(3), POLQ(12)	19491005	38	35	36	5	3	3	2	14	16	0	0.158	0.996	1.000
222	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(5), PARK2(4), SNCAIP(5), UBE2E2(1), UBE2L3(1)	7467277	16	16	16	5	1	4	2	6	3	0	0.588	0.996	1.000
223	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	26	AKT1(1), AKT2(4), AKT3(2), GRB2(3), GSK3A(1), GSK3B(3), IL4R(5), IRS1(6), JAK1(6), JAK3(4), MAP4K1(3), MAPK1(1), MAPK3(3), PDK1(1), PIK3CA(16), PIK3CD(2), PIK3R1(5), PPP1R13B(6), RAF1(5), SHC1(4), SOCS1(1), SOS1(7), SOS2(7), STAT6(4)	41404962	100	88	92	16	13	20	15	34	18	0	0.00391	0.997	1.000
224	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(1), HMOX1(3), IL10RA(3), IL10RB(1), JAK1(6), STAT1(6), STAT3(4), STAT5A(4), TNF(1)	14310346	29	29	28	6	4	1	1	11	12	0	0.686	0.997	1.000
225	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(3), IFNB1(2), JAK1(6), PTPRU(6), STAT1(6), STAT2(7), TYK2(7)	14548500	37	32	36	9	5	4	4	12	12	0	0.317	0.997	1.000
226	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	ADAM17(3), APC(11), AXIN1(5), BTRC(4), CTNNB1(4), DLL1(1), DVL1(1), FZD1(2), GSK3B(3), NOTCH1(9), PSEN1(1), WNT1(2)	24213001	46	44	43	7	4	5	3	22	11	1	0.108	0.997	1.000
227	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(2), B4GALT1(2), B4GALT2(1), B4GALT3(2), B4GALT5(3), ST3GAL1(2), ST3GAL3(3), ST3GAL4(2)	9064046	17	16	16	8	1	0	2	5	9	0	0.984	0.997	1.000
228	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(1), GRB2(3), IL4(1), IL4R(5), IRS1(6), JAK1(6), JAK3(4), RPS6KB1(2), SHC1(4), STAT6(4)	16903039	36	34	36	8	6	3	6	12	9	0	0.306	0.997	1.000
229	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(4), ANKRD1(1), EIF4E(2), IFNG(2), IFRD1(1), IL18(1), IL1R1(3), NR4A3(2), WDR1(1)	12784417	17	17	17	4	1	3	3	5	5	0	0.502	0.997	1.000
230	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	ADCY1(2), AKT1(1), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CREB1(1), GNAS(5), GRB2(3), HRAS(1), MAPK1(1), MAPK14(2), MAPK3(3), PIK3CA(16), PIK3R1(5), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4), PRKCA(3), RPS6KA1(7), RPS6KA5(3), SOS1(7)	34198224	80	75	70	13	9	19	5	30	16	1	0.0290	0.997	1.000
231	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	DAB1(6), FYN(2), LRP8(6), RELN(8), VLDLR(3)	16515271	25	24	20	4	1	5	1	7	11	0	0.525	0.998	1.000
232	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(2), ALDH4A1(2), CAD(13), CPS1(5), EPRS(3), GAD1(2), GAD2(3), GCLC(4), GCLM(1), GFPT1(3), GLS(9), GLS2(4), GLUD1(1), GLUL(2), GMPS(1), GOT1(3), GOT2(3), GPT(4), GPT2(2), GSS(1), NADSYN1(1), PPAT(3), QARS(4)	39226451	76	68	72	10	4	7	15	27	22	1	0.0280	0.998	1.000
233	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	14	BPNT1(3), CHST11(1), CHST12(2), CHST13(1), PAPSS1(3), PAPSS2(4), SULT1A1(2), SULT2A1(1), SUOX(5)	11817656	22	21	21	5	3	2	5	3	9	0	0.523	0.998	1.000
234	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(2), ACAA1(4), ACADM(3), ACADS(3), ACAT1(1), ALDH1A3(4), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ALDH6A1(1), ALDH7A1(1), AOX1(8), BCAT1(1), BCKDHA(2), DBT(1), DLD(4), ECHS1(3), EHHADH(6), HADH(1), HADHA(4), HADHB(4), HIBADH(1), HMGCL(2), HMGCS1(4), HMGCS2(3), HSD17B4(1), IVD(2), MCCC1(3), MCCC2(4), MCEE(1), MUT(2), OXCT1(2), PCCA(2), PCCB(4)	51355767	94	90	90	12	7	9	19	35	23	1	0.00473	0.998	1.000
235	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(2), IL4R(5), JAK1(6), JAK2(7), TYK2(7)	12218455	27	26	26	9	3	0	6	8	10	0	0.829	0.998	1.000
236	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(2), IL4R(5), JAK1(6), JAK2(7), TYK2(7)	12218455	27	26	26	9	3	0	6	8	10	0	0.829	0.998	1.000
237	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(2), B4GALNT1(1), GLB1(5), HEXA(5), HEXB(1), LCT(5), SLC33A1(2), ST3GAL1(2), ST3GAL5(1), ST6GALNAC3(3), ST6GALNAC4(1), ST6GALNAC5(5), ST6GALNAC6(1), ST8SIA1(2), ST8SIA5(3)	19004529	39	36	39	8	3	8	2	16	10	0	0.153	0.998	1.000
238	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(1), COASY(2), DPYD(5), DPYS(3), ENPP1(2), ENPP3(2), PANK1(4), PANK2(5), PANK3(2), PANK4(1), UPB1(2)	16311597	29	28	29	7	3	3	5	9	9	0	0.379	0.999	1.000
239	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT1(1), ACOT11(2), DHRS2(1), DHRSX(5), ECHS1(3), EHHADH(6), ESCO1(4), ESCO2(1), FN3K(1), GCDH(5), HADHA(4), PNPLA3(3), SH3GLB1(3), YOD1(2)	30406528	41	39	34	4	2	7	6	8	18	0	0.0677	0.999	1.000
240	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ3(1), COQ5(2), COQ6(1), COQ7(1), NDUFA13(2)	4897379	7	7	7	4	3	1	0	2	1	0	0.864	0.999	1.000
241	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(4), ACADL(3), ACADM(3), ACADS(3), ACADSB(1), ACAT1(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(4), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ALDH6A1(1), AOX1(8), BCAT1(1), BCKDHA(2), ECHS1(3), EHHADH(6), HADHA(4), HADHB(4), HIBADH(1), HMGCL(2), IVD(2), MCCC1(3), MCCC2(4), MCEE(1), MUT(2), OXCT1(2), PCCA(2), PCCB(4)	42709538	83	80	79	13	6	10	18	30	19	0	0.0236	0.999	1.000
242	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(5), CS(3), GRHPR(2), HAO1(2), HAO2(1), MDH1(1), MDH2(1), MTHFD1(7), MTHFD1L(4), MTHFD2(2)	15129445	28	28	28	7	4	3	3	14	4	0	0.414	0.999	1.000
243	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(2), CALCR(5), CALCRL(3), CD97(7), CRHR1(2), CRHR2(4), ELTD1(4), EMR1(2), EMR2(3), GIPR(2), GLP1R(3), GLP2R(5), GPR64(2), LPHN1(6), LPHN2(4), LPHN3(11), SCTR(1), VIPR1(1), VIPR2(1)	32308051	68	61	66	12	10	8	11	26	12	1	0.0301	0.999	1.000
244	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	LDLR(4), NR1H3(2), NR1H4(2), RXRA(2)	6175692	10	10	10	4	0	4	0	3	3	0	0.724	0.999	1.000
245	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(10), ACO1(5), CLYBL(3), CS(3), DLD(4), FH(2), IDH1(2), IDH2(6), IDH3B(2), IDH3G(2), MDH1(1), MDH2(1), OGDH(8), OGDHL(3), PC(8), PCK1(9), PCK2(2), SDHA(8), SDHB(1), SDHD(2), SUCLA2(2), SUCLG1(6), SUCLG2(2)	35143242	92	79	89	18	6	14	10	32	29	1	0.100	0.999	1.000
246	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(5), CS(3), GRHPR(2), HAO1(2), HAO2(1), MDH1(1), MDH2(1), MTHFD1(7), MTHFD1L(4), MTHFD2(2)	15869680	28	28	28	7	4	3	3	14	4	0	0.414	0.999	1.000
247	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(2), GNB1(3), HTR2C(1), PLCB1(3), TUB(3)	8368268	12	11	12	4	1	2	0	7	2	0	0.696	0.999	1.000
248	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(2), CD3E(1), CD3G(2), CD4(10), CREBBP(13), CSK(4), GNAS(5), GNB1(3), HLA-DRA(1), HLA-DRB1(6), LCK(1), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4), PTPRC(7), ZAP70(1)	26459766	68	60	62	13	5	8	8	27	19	1	0.243	0.999	1.000
249	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(2), CD3E(1), CD3G(2), CD4(10), CREBBP(13), CSK(4), GNAS(5), GNB1(3), HLA-DRA(1), HLA-DRB1(6), LCK(1), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4), PTPRC(7), ZAP70(1)	26459766	68	60	62	13	5	8	8	27	19	1	0.243	0.999	1.000
250	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	ASAH1(2), BFAR(2), BRAF(6), CREB1(1), CREB5(3), MAPK1(1), RAF1(5), SNX13(3), SRC(2), TERF2IP(1)	13595024	26	22	25	6	1	6	4	9	5	1	0.359	0.999	1.000
251	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(2), GNAS(5), GNB1(3), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4), PRKCA(3)	11260408	25	24	25	6	3	3	1	12	6	0	0.567	0.999	1.000
252	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(6), CARS2(3), CTH(2), GOT1(3), GOT2(3), LDHAL6B(1), LDHB(1), LDHC(3), MPST(2), SULT1B1(3), SULT1C4(5), SULT4A1(1)	14776777	33	33	31	9	2	2	5	10	14	0	0.812	0.999	1.000
253	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(1), AOC2(5), AOC3(1), CES1(8), DDHD1(3), ESCO1(4), ESCO2(1), LIPA(1), PLA1A(4), PNPLA3(3), PRDX6(2), SH3GLB1(3)	29648540	36	34	34	3	1	6	3	12	14	0	0.0413	0.999	1.000
254	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(9), CD44(3), IL1B(1), IL6R(2), SELL(2), SPN(1), TGFB2(2), TNF(1), TNFRSF1A(1), TNFRSF1B(2), TNFRSF8(1), TNFSF8(2)	15603561	27	25	25	5	2	7	4	6	8	0	0.257	0.999	1.000
255	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARSA(3), GOT1(3), GOT2(3), PAH(5), TAT(3), YARS(1), YARS2(1)	10272578	19	18	19	5	2	2	3	5	7	0	0.686	0.999	1.000
256	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(4), CHIA(5), CHIT1(5), CMAS(1), CYB5R1(2), CYB5R3(2), GFPT1(3), GFPT2(3), GNE(2), GNPDA1(1), GNPNAT1(2), HEXA(5), HEXB(1), HK1(7), MTMR1(2), MTMR2(3), MTMR6(1), NAGK(3), NANS(3), NPL(6), PHPT1(1), RENBP(5), UAP1(1)	33858755	68	64	65	10	7	7	12	24	17	1	0.0122	0.999	1.000
257	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	52	ACTA1(1), AGT(4), AKT1(1), CALM2(1), CALR(2), CAMK1(3), CAMK1G(4), CAMK4(3), CREBBP(13), CSNK1A1(2), ELSPBP1(2), F2(4), GATA4(2), GSK3B(3), HAND2(1), HRAS(1), LIF(1), MAPK1(1), MAPK14(2), MAPK3(3), MEF2C(1), MYH2(9), NFATC1(4), NFATC2(6), NFATC3(8), NFATC4(3), NKX2-5(1), NPPA(1), PIK3CA(16), PIK3R1(5), PPP3CA(2), PPP3CB(1), PPP3CC(3), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4), RAF1(5), RPS6KB1(2), SYT1(1)	58954663	134	114	123	22	17	19	15	42	41	0	0.00453	0.999	1.000
258	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(1), CAPN1(2), CSNK1A1(2), GSK3B(3), MAPT(5), PPP2CA(1)	11058258	14	14	12	7	0	1	2	2	9	0	0.957	0.999	1.000
259	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(4), ABAT(2), ADSL(2), AGXT(2), AGXT2(1), ASL(4), ASNS(2), ASPA(1), CAD(13), CRAT(2), DARS(4), DDO(1), GAD1(2), GAD2(3), GOT1(3), GOT2(3), GPT(4), GPT2(2), PC(8)	30610344	63	56	59	10	1	8	11	15	27	1	0.127	0.999	1.000
260	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(7), GNA12(1), PRKACB(2), PRKACG(3), PRKAG1(6), PRKAR2B(4)	11829678	23	23	23	6	3	3	5	8	4	0	0.397	0.999	1.000
261	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(4), BIRC2(3), BIRC3(6), CASP10(3), CASP7(1), CASP8(1), CASP9(2), DFFA(1), DFFB(1), PRF1(1), SCAP(3), SREBF1(4), SREBF2(11)	21330582	41	39	41	8	2	7	6	13	13	0	0.189	1.000	1.000
262	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(1), ACP2(2), ACP5(2), ACP6(1), ENPP1(2), ENPP3(2), FLAD1(5), MTMR1(2), MTMR2(3), MTMR6(1), PHPT1(1), TYR(5)	17715684	27	26	27	5	0	5	1	16	5	0	0.378	1.000	1.000
263	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	B3GALT1(1), B3GALT2(2), B3GALT5(3), B3GNT5(1), FUT2(1), FUT3(2), ST3GAL3(3), ST3GAL4(2)	8269899	15	14	13	6	5	0	2	2	6	0	0.846	1.000	1.000
264	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(2), JAK1(6), JAK2(7), JAK3(4), PIAS1(5), PIAS3(3), PTPRU(6), SOAT1(5)	16243447	38	33	36	9	2	2	8	15	11	0	0.427	1.000	1.000
265	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	82	AIFM1(5), AKT1(1), AKT2(4), AKT3(2), APAF1(4), ATM(23), BAX(1), BID(2), BIRC2(3), BIRC3(6), CAPN1(2), CAPN2(3), CASP10(3), CASP6(1), CASP7(1), CASP8(1), CASP9(2), CFLAR(3), CHUK(2), CSF2RB(7), DFFA(1), DFFB(1), FAS(2), FASLG(2), IKBKB(3), IL1B(1), IL1R1(3), IL1RAP(4), IL3(1), IRAK1(3), IRAK3(4), IRAK4(1), NFKB1(1), NFKB2(3), NFKBIA(1), NTRK1(6), PIK3CA(16), PIK3CB(6), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(6), PPP3CA(2), PPP3CB(1), PPP3CC(3), PRKACA(1), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4), RELA(7), RIPK1(2), TNF(1), TNFRSF10B(1), TNFRSF10C(2), TNFRSF10D(1), TNFRSF1A(1), TNFSF10(9), TP53(50), TRADD(2), TRAF2(1)	98950314	252	192	227	32	23	38	31	88	67	5	6.55e-07	1.000	1.000
266	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	AKT1(1), CASP9(2), CDC42(1), CHUK(2), ELK1(2), HRAS(1), MAPK3(3), NFKB1(1), PIK3CA(16), PIK3R1(5), RAF1(5), RALA(3), RALBP1(3), RELA(7)	22631222	52	50	42	10	4	16	3	15	13	1	0.153	1.000	1.000
267	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(7), KHK(5), LCT(5), MPI(2), PGM1(1), PYGL(1), PYGM(4), TPI1(1)	15986360	26	25	26	6	5	2	4	9	6	0	0.308	1.000	1.000
268	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(2), ACADM(3), ALDH1A3(4), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ALDH7A1(1), AOC2(5), AOC3(1), CNDP1(4), DPYD(5), DPYS(3), ECHS1(3), EHHADH(6), GAD1(2), GAD2(3), HADHA(4), MLYCD(3), SMS(2), UPB1(2)	31520225	63	59	60	12	4	7	15	17	19	1	0.0753	1.000	1.000
269	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(1), GPR161(1), GPR171(1), GPR18(2), GPR34(1), GPR39(2), GPR45(3), GPR65(5), GPR75(1)	11457683	17	17	17	5	3	3	0	8	2	1	0.410	1.000	1.000
270	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(3), CHUK(2), IFNG(2), IKBKB(3), IL2(1), IL4(1), JUN(2), MAP3K1(8), MAP3K5(5), MAP4K5(4), MAPK14(2), NFKB1(1), NFKBIA(1), RELA(7), TNFRSF9(1), TNFSF9(1), TRAF2(1)	23191235	45	38	42	8	1	4	1	19	19	1	0.528	1.000	1.000
271	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	33	AKT1(1), AKT2(4), AKT3(2), BCR(2), CD19(1), CDKN2A(4), DAPP1(1), FLOT1(1), FLOT2(1), GAB1(1), ITPR1(11), ITPR2(14), ITPR3(7), LYN(3), PDK1(1), PIK3CA(16), PITX2(2), PLCG2(3), PPP1R13B(6), PREX1(9), PTEN(35), PTPRC(7), RPS6KA1(7), RPS6KA3(2), RPS6KB1(2), SAG(5), SYK(2), TEC(5), VAV1(6)	65169708	161	139	151	27	11	27	18	48	52	5	0.00496	1.000	1.000
272	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(2), PLCG1(3), PRKCA(3), PTK2B(4)	7893439	12	12	11	6	1	3	1	2	5	0	0.932	1.000	1.000
273	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	AKT1(1), CREB1(1), MAP2K2(1), MAP2K3(3), MAP3K1(8), MAPK1(1), MAPK14(2), MAPK3(3), NFKB1(1), PIK3CA(16), PIK3R1(5), RB1(4), RELA(7), SP1(2)	23167264	55	50	46	10	4	13	2	18	15	3	0.207	1.000	1.000
274	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	CSNK2A1(3), ELK1(2), FOS(1), GRB2(3), HRAS(1), IGF1R(4), IRS1(6), JUN(2), MAPK3(3), PIK3CA(16), PIK3R1(5), PTPN11(1), RAF1(5), RASA1(7), SHC1(4), SOS1(7)	28625372	70	65	64	14	10	20	6	23	11	0	0.0528	1.000	1.000
275	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(4), CLOCK(2), CRY1(1), CSNK1E(3), PER1(8)	9954612	18	18	17	5	2	0	3	7	6	0	0.650	1.000	1.000
276	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	48	AKT1(1), AKT2(4), AKT3(2), BRD4(6), CBL(2), CDC42(1), CDKN2A(4), F2RL2(2), FLOT1(1), FLOT2(1), GRB2(3), GSK3A(1), GSK3B(3), IGFBP1(1), INPPL1(4), IRS1(6), IRS4(1), LNPEP(4), MAPK1(1), MAPK3(3), PARD3(7), PDK1(1), PIK3CA(16), PIK3CD(2), PIK3R1(5), PTEN(35), PTPN1(2), RAF1(5), RPS6KA1(7), RPS6KA3(2), RPS6KB1(2), SFN(1), SHC1(4), SLC2A4(3), SORBS1(2), SOS1(7), SOS2(7), YWHAB(1)	67581897	160	138	146	27	15	22	22	44	52	5	0.00973	1.000	1.000
277	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS2(1), DHRSX(5), ESCO1(4), ESCO2(1), PNPLA3(3), SH3GLB1(3)	19334188	17	17	13	1	0	3	2	4	8	0	0.212	1.000	1.000
278	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(2), ADRB2(2), GNAS(5), PLCE1(5), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4), RAP2B(2)	17159196	28	28	28	6	3	4	3	10	8	0	0.398	1.000	1.000
279	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOA(2), ALDOB(5), GOT1(3), GOT2(3), GPT(4), GPT2(2), MDH1(1), MDH2(1), ME1(1), ME2(3), ME3(2), PGK1(3), PKLR(1), RPE(2), RPIA(3), TKT(3), TPI1(1)	21056188	40	37	39	9	2	7	6	7	18	0	0.444	1.000	1.000
280	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(1), ADCY1(2), CDC25C(4), GNAI1(3), GNAS(5), GNB1(3), HRAS(1), MAPK1(1), MAPK3(3), MYT1(9), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4), RPS6KA1(7), SRC(2)	23830780	53	48	49	10	6	11	4	21	10	1	0.119	1.000	1.000
281	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(11), ABCC2(5), ABCG2(1), BCHE(2), CES1(8), CES2(2), CYP3A5(1), UGT1A1(5), UGT1A10(1), UGT1A3(2), UGT1A4(3), UGT1A5(4), UGT1A6(5), UGT1A7(4), UGT1A9(6)	27159877	60	52	55	13	4	7	13	17	19	0	0.327	1.000	1.000
282	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCL3(1), CCR2(2), CCR3(1), CCR5(1), CCR7(1), CD28(1), CD4(10), CXCR4(1), IFNG(2), IFNGR1(3), IFNGR2(2), IL12RB1(3), IL12RB2(3), IL18R1(1), IL2(1), IL4(1), IL4R(5), TGFB2(2)	23613749	41	40	35	8	5	2	5	13	15	1	0.371	1.000	1.000
283	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(1), CYP11A1(2), CYP11B1(4), CYP11B2(2), CYP17A1(2), CYP21A2(1), HSD11B1(1), HSD11B2(1), HSD3B1(1)	10602345	15	15	15	7	1	0	2	7	5	0	0.800	1.000	1.000
284	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(1), CYP11A1(2), CYP11B1(4), CYP11B2(2), CYP17A1(2), CYP21A2(1), HSD11B1(1), HSD11B2(1), HSD3B1(1)	10602345	15	15	15	7	1	0	2	7	5	0	0.800	1.000	1.000
285	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(2), B3GNT2(4), B3GNT7(1), B4GALT1(2), B4GALT2(1), B4GALT3(2), B4GALT4(2), CHST1(2), CHST2(4), CHST4(1), CHST6(1), ST3GAL1(2), ST3GAL3(3), ST3GAL4(2)	13759447	29	26	28	9	2	4	2	6	15	0	0.861	1.000	1.000
286	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(2), GBA(2), LPO(2), MPO(5), PRDX6(2), TPO(4)	9788037	17	16	17	5	0	2	4	5	6	0	0.633	1.000	1.000
287	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(4), AARS2(5), ABAT(2), ACY3(1), ADSL(2), ADSSL1(3), AGXT(2), AGXT2(1), ASL(4), ASNS(2), ASPA(1), ASRGL1(4), ASS1(2), CAD(13), CRAT(2), DARS(4), DARS2(1), DDO(1), DLAT(3), DLD(4), GAD1(2), GAD2(3), GOT1(3), GOT2(3), GPT(4), GPT2(2), NARS2(6), PC(8), PDHA1(1), PDHA2(3), PDHB(1)	44493678	97	79	90	15	5	12	14	27	37	2	0.0377	1.000	1.000
288	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(1), IFNAR1(3), IFNB1(2), NFKB1(1), RELA(7), TNFRSF11A(2), TRAF6(2)	12774581	18	18	15	6	1	5	1	2	8	1	0.836	1.000	1.000
289	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(1), GALNS(6), GLB1(5), GNS(3), GUSB(5), HEXA(5), HEXB(1), HGSNAT(3), HPSE(2), HPSE2(4), HYAL1(2), HYAL2(2), IDS(2), IDUA(2), LCT(5), NAGLU(3), SPAM1(8)	24277195	59	50	59	13	9	9	8	20	13	0	0.105	1.000	1.000
290	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CCL2(1), IL1B(1), MST1R(1), TNF(1)	7202206	4	4	4	2	0	1	0	1	2	0	0.944	1.000	1.000
291	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	AKT1(1), GRB2(3), HRAS(1), IGF1R(4), IRS1(6), MAPK1(1), MAPK3(3), PIK3CA(16), PIK3R1(5), RAF1(5), SHC1(4), SOS1(7)	21871187	56	51	50	12	9	14	4	21	8	0	0.101	1.000	1.000
292	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(3), GABRA2(1), GABRA3(2), GABRA4(1), GABRA5(1), GABRA6(1), PRKCE(4)	8905159	13	13	13	9	1	0	3	6	3	0	0.984	1.000	1.000
293	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CHPT1(2), LCMT1(1), LCMT2(4), METTL2B(1), PCYT1A(2), PRMT2(1), PRMT3(2), PRMT5(5), PRMT6(2), PRMT7(3), PRMT8(3)	16369350	26	23	26	5	2	2	5	9	8	0	0.418	1.000	1.000
294	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(3), EGF(5), EGFR(10), ELK1(2), FOS(1), GRB2(3), HRAS(1), JAK1(6), JUN(2), MAP3K1(8), MAPK3(3), PIK3CA(16), PIK3R1(5), PLCG1(3), PRKCA(3), RAF1(5), RASA1(7), SHC1(4), SOS1(7), STAT1(6), STAT3(4), STAT5A(4)	44133369	108	94	98	19	11	22	11	33	31	0	0.0524	1.000	1.000
295	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A2(1), ALDH1A3(4), ALDH1B1(3), ALDH2(4), ALDH3A2(3)	9366198	16	16	14	5	2	1	3	5	5	0	0.752	1.000	1.000
296	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A2(1), ALDH1A3(4), ALDH1B1(3), ALDH2(4), ALDH3A2(3)	9366198	16	16	14	5	2	1	3	5	5	0	0.752	1.000	1.000
297	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(6), CYP2A13(6), CYP2A6(1), CYP2A7(2), NAT1(1), NAT2(1), XDH(7)	9346798	24	24	24	9	4	2	3	10	5	0	0.849	1.000	1.000
298	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CD4(10), HLA-DRA(1), HLA-DRB1(6), IFNA1(1), IFNB1(2), IFNG(2), IL15(1), IL2(1), IL3(1), IL4(1), LTA(1), TGFB2(2), TNF(1)	15409241	30	28	24	7	0	6	3	8	12	1	0.678	1.000	1.000
299	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	ADAM17(3), DLL1(1), FURIN(3), NOTCH1(9), PSEN1(1)	10180266	17	17	15	5	2	2	0	7	5	1	0.763	1.000	1.000
300	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(3), EIF2AK4(8), EIF2B5(3), EIF2S2(2), EIF2S3(2), EIF5(4), GSK3B(3)	13614975	25	23	23	7	2	2	6	5	10	0	0.618	1.000	1.000
301	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(11), AXIN1(5), BTRC(4), CREBBP(13), CSNK1A1(2), CSNK2A1(3), CTBP1(2), CTNNB1(4), DVL1(1), FZD1(2), GSK3B(3), HDAC1(2), MAP3K7(3), MYC(1), PPARD(1), PPP2CA(1), TLE1(6), WIF1(5), WNT1(2)	34392307	71	63	65	13	6	6	10	26	23	0	0.108	1.000	1.000
302	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(1), CYB5R3(2), GCK(1), GFPT1(3), GNE(2), GNPDA1(1), HEXA(5), HEXB(1), HK1(7), RENBP(5), UAP1(1)	20015585	29	27	29	6	3	2	5	11	8	0	0.292	1.000	1.000
303	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	CSNK2A1(3), FOS(1), GRB2(3), HRAS(1), JAK2(7), JUN(2), MAPK3(3), PIK3CA(16), PIK3R1(5), PLCG1(3), PRKCA(3), RAF1(5), RASA1(7), SHC1(4), SOS1(7), STAT1(6), STAT3(4), STAT5A(4), STAT5B(4), THPO(1)	35283007	89	80	81	17	8	18	11	30	22	0	0.128	1.000	1.000
304	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	21	ATM(23), ATR(11), BRCA1(8), BRCA2(10), CHEK1(1), CHEK2(3), FANCA(6), FANCD2(1), FANCE(2), FANCF(2), FANCG(3), HUS1(2), MRE11A(4), RAD17(2), RAD50(4), RAD51(2), TP53(50), TREX1(3)	52242510	137	112	127	23	10	21	16	49	37	4	0.0188	1.000	1.000
305	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA2A(5), ADORA2B(1), ADORA3(2), P2RY1(3), P2RY2(2)	6565915	13	12	13	6	3	2	2	5	1	0	0.657	1.000	1.000
306	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(3), ELK1(2), EPOR(1), FOS(1), GRB2(3), HRAS(1), JAK2(7), JUN(2), MAPK3(3), PLCG1(3), PTPN6(3), RAF1(5), SHC1(4), SOS1(7), STAT5A(4), STAT5B(4)	25323206	53	49	51	10	4	7	10	18	14	0	0.196	1.000	1.000
307	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	AKT1(1), CHRNB1(4), MUSK(3), PIK3CA(16), PIK3R1(5), PTK2(3), PTK2B(4), SRC(2), TERT(10)	19366274	48	44	42	11	5	18	2	15	8	0	0.106	1.000	1.000
308	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	34	AKT1(1), APC(11), AR(18), ASAH1(2), BRAF(6), DAG1(3), EGFR(10), GNA15(1), GNAI1(3), ITPKA(1), ITPKB(3), ITPR1(11), ITPR2(14), ITPR3(7), KCNJ3(4), MAPK1(1), MAPK10(2), MAPK14(2), PHKA2(5), PIK3CA(16), PIK3CD(2), PIK3R1(5), PITX2(2), RAF1(5), SRC(2)	62779531	137	116	120	23	12	26	20	55	23	1	0.00258	1.000	1.000
309	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(1), APAF1(4), CASP9(2), DAXX(6), FAS(2), FASLG(2), HSPB2(3), MAPKAPK2(2), TNF(1)	12987058	23	21	23	6	2	5	3	7	6	0	0.479	1.000	1.000
310	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(3), CAMK1G(4), HDAC9(3), MEF2A(2), MEF2C(1), MEF2D(1)	9621659	14	14	13	7	2	1	2	5	4	0	0.880	1.000	1.000
311	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNA1(1), IFNB1(2), IFNG(2), IL15(1), IL16(5), IL18(1), IL2(1), IL3(1), IL4(1), IL9(1), LTA(1), TNF(1)	11552356	18	17	18	7	0	4	2	8	4	0	0.834	1.000	1.000
312	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(2), ADH1B(2), ADH4(1), ADH5(1), ADH6(3), ADHFE1(3), ALDH1A3(4), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ALDH7A1(1)	15729931	27	27	24	8	3	1	2	12	9	0	0.765	1.000	1.000
313	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(2), ALDH4A1(2), CAD(13), CPS1(5), EPRS(3), GAD1(2), GAD2(3), GCLC(4), GCLM(1), GFPT1(3), GFPT2(3), GLS(9), GLS2(4), GLUD1(1), GLUD2(1), GLUL(2), GMPS(1), GNPNAT1(2), GOT1(3), GOT2(3), GPT(4), GPT2(2), GSR(2), GSS(1), NADSYN1(1), NAGK(3), PPAT(3), QARS(4)	46608090	87	77	83	14	6	7	20	30	23	1	0.0457	1.000	1.000
314	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(2), ALDH1A3(4), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ALDH7A1(1), CYP2C19(1), CYP2C9(1), DHRS2(1), DHRSX(5), ECHS1(3), EHHADH(6), ESCO1(4), ESCO2(1), HADHA(4), PNPLA3(3), SH3GLB1(3), YOD1(2)	36274605	51	48	44	7	3	7	8	12	21	0	0.0949	1.000	1.000
315	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(2), IFNA1(1), IFNB1(2), IKBKB(3), IL1B(1), IL1R1(3), IL1RAP(4), IL1RN(1), IRAK1(3), IRAK3(4), JUN(2), MAP2K3(3), MAP3K1(8), MAP3K7(3), MAPK14(2), NFKB1(1), NFKBIA(1), RELA(7), TGFB2(2), TNF(1), TRAF6(2)	34819817	56	50	52	9	6	11	1	18	19	1	0.173	1.000	1.000
316	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(2), ST3GAL1(2), ST3GAL4(2), ST3GAL5(1), ST6GALNAC2(3), ST6GALNAC4(1), ST8SIA1(2)	6435518	13	13	13	5	1	3	1	7	1	0	0.581	1.000	1.000
317	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	CS(3), DLAT(3), DLD(4), FH(2), IDH2(6), IDH3B(2), IDH3G(2), MDH1(1), MDH2(1), OGDH(8), PC(8), PDHA1(1), PDHA2(3), PDHB(1), PDHX(1), PDK1(1), PDK2(4), PDK3(2), PDK4(2), PDP2(2), SDHA(8), SDHB(1), SDHD(2), SUCLA2(2), SUCLG1(6), SUCLG2(2)	33507876	78	67	75	17	3	13	10	25	26	1	0.183	1.000	1.000
318	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(2), HS3ST1(1), HS3ST2(2), HS3ST3A1(1), XYLT1(4), XYLT2(2)	7336486	12	12	12	9	4	3	0	4	1	0	0.908	1.000	1.000
319	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(2), HS3ST1(1), HS3ST2(2), HS3ST3A1(1), XYLT1(4), XYLT2(2)	7336486	12	12	12	9	4	3	0	4	1	0	0.908	1.000	1.000
320	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(2), FOS(1), HRAS(1), JUN(2), MAPK1(1), MAPK3(3), MYC(1), NFKB1(1), NFKBIA(1), PLCB1(3), PRKCA(3), RAF1(5), RELA(7), TNF(1)	17910353	32	31	29	9	6	3	2	8	12	1	0.720	1.000	1.000
321	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	44	AKT1(1), AKT2(4), AKT3(2), BRAF(6), CAB39(1), DDIT4(1), EIF4B(4), FIGF(2), HIF1A(5), INS(1), MAPK1(1), MAPK3(3), PGF(2), PIK3CA(16), PIK3CB(6), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(6), PRKAA1(2), PRKAA2(4), RHEB(4), RICTOR(5), RPS6KA1(7), RPS6KA3(2), RPS6KA6(1), RPS6KB1(2), RPS6KB2(3), STK11(2), TSC1(5), TSC2(14), ULK1(2), ULK2(3), ULK3(4), VEGFA(1), VEGFC(2)	62674763	139	126	120	24	15	20	16	47	35	6	0.0117	1.000	1.000
322	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(4), BAX(1), BCL10(2), BCL2L11(1), BID(2), CASP9(2), CES1(8)	13495874	20	20	18	5	0	3	1	8	8	0	0.684	1.000	1.000
323	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(4), CBS(1), CTH(2), GGT1(4), LCMT1(1), LCMT2(4), MARS(3), MARS2(3), MAT1A(1), MAT2B(1), METTL2B(1), PAPSS1(3), PAPSS2(4), PRMT2(1), PRMT3(2), PRMT5(5), PRMT6(2), PRMT7(3), PRMT8(3), SCLY(3), SEPHS1(1), SEPHS2(2)	28969793	54	50	54	10	4	5	14	16	15	0	0.170	1.000	1.000
324	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(3), GUSB(5), RPE(2), UGDH(1), UGP2(1), UGT1A1(5), UGT1A10(1), UGT1A3(2), UGT1A4(3), UGT1A5(4), UGT1A6(5), UGT1A7(4), UGT1A9(6), UGT2A1(5), UGT2A3(2), UGT2B11(2), UGT2B15(1), UGT2B28(4), UGT2B4(4), UGT2B7(6), XYLB(4)	31485702	70	64	70	15	5	9	17	21	18	0	0.203	1.000	1.000
325	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(2), FUCA2(1), GLB1(5), HEXA(5), HEXB(1), LCT(5), MAN2C1(6), MANBA(2), NEU1(1)	19064206	28	27	28	7	2	4	2	13	7	0	0.404	1.000	1.000
326	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(2), CREM(1), FHL5(3), FSHR(2), GNAS(5), XPO1(7)	11072456	20	20	20	6	4	1	4	7	4	0	0.728	1.000	1.000
327	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(3), ELK1(2), FOS(1), GRB2(3), HRAS(1), JAK1(6), JUN(2), MAP3K1(8), MAPK3(3), PDGFRA(6), PIK3CA(16), PIK3R1(5), PLCG1(3), PRKCA(3), RAF1(5), RASA1(7), SHC1(4), SOS1(7), STAT1(6), STAT3(4), STAT5A(4)	41149384	99	88	91	18	10	21	9	32	27	0	0.0669	1.000	1.000
328	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	16	CHUK(2), CREBBP(13), EP300(16), IKBKB(3), NFKB1(1), NFKBIA(1), RELA(7), RIPK1(2), TNF(1), TNFRSF1A(1), TNFRSF1B(2), TRADD(2), TRAF6(2)	26534389	53	48	47	11	2	7	10	10	23	1	0.340	1.000	1.000
329	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD28(1), CD86(3), HLA-DRA(1), HLA-DRB1(6), IFNG(2), IFNGR1(3), IFNGR2(2), IL12RB1(3), IL12RB2(3), IL18(1), IL18R1(1), IL2(1), IL2RA(2), IL4(1), IL4R(5)	14751873	35	33	35	10	5	3	3	11	13	0	0.621	1.000	1.000
330	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(3), ALDH18A1(2), ARG1(2), ARG2(1), ASL(4), CKB(1), CKMT1B(1), CPS1(5), GATM(2), GLUD1(1), NAGS(1), OAT(3), ODC1(3), OTC(1), PYCR1(1), SMS(2)	21038884	33	33	33	8	0	2	6	13	12	0	0.659	1.000	1.000
331	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(1), HK1(7), IMPA1(1), PGM1(1)	12029426	10	9	10	7	2	1	0	3	4	0	0.954	1.000	1.000
332	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(1), FUT2(1), GBGT1(3), GLA(1), HEXA(5), HEXB(1), ST3GAL1(2), ST3GAL4(2), ST8SIA1(2)	11650638	18	18	18	6	1	2	1	10	4	0	0.639	1.000	1.000
333	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(2), ACADL(3), ACADM(3), ACADSB(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(4), ALDH1B1(3), ALDH2(4), ALDH3A2(3), AOC2(5), AOC3(1), CNDP1(4), DPYD(5), DPYS(3), ECHS1(3), EHHADH(6), GAD1(2), GAD2(3), HADHA(4), MLYCD(3), SMS(2), UPB1(2)	33945269	68	64	65	15	4	9	18	18	18	1	0.124	1.000	1.000
334	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(4), ACADL(3), ACADM(3), ACADS(3), ACADSB(1), ACAT1(1), ACOX1(2), ACOX3(5), ACSL1(2), ACSL3(13), ACSL4(1), ACSL5(1), ACSL6(5), ADH1A(2), ADH1B(2), ADH4(1), ADH5(1), ADH6(3), ADHFE1(3), ALDH1A3(4), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ALDH7A1(1), CPT1A(3), CPT1B(1), CPT1C(5), CPT2(2), CYP4A11(6), ECHS1(3), EHHADH(6), GCDH(5), HADH(1), HADHA(4), HADHB(4), HSD17B4(1)	57864343	112	95	93	20	8	15	21	43	25	0	0.0212	1.000	1.000
335	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(2), ADRB2(2), CFTR(6), GNAS(5), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4), SLC9A3R1(1)	15154538	28	28	28	8	3	3	1	14	7	0	0.736	1.000	1.000
336	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(3), ELK1(2), FOS(1), GRB2(3), HRAS(1), IL2(1), IL2RA(2), IL2RB(2), JAK1(6), JAK3(4), JUN(2), LCK(1), MAPK3(3), RAF1(5), SHC1(4), SOS1(7), STAT5A(4), STAT5B(4), SYK(2)	27463900	57	54	56	12	7	8	10	18	14	0	0.185	1.000	1.000
337	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(2), ACOX3(5), FADS2(2), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(5)	12333616	19	19	19	6	3	6	2	6	2	0	0.368	1.000	1.000
338	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	AKT1(1), DPM2(1), GRB2(3), HRAS(1), NTRK1(6), PIK3CA(16), PIK3R1(5), PLCG1(3), PRKCA(3), SHC1(4), SOS1(7)	18221875	50	47	42	12	3	15	3	18	11	0	0.303	1.000	1.000
339	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(2), FUCA2(1), GLB1(5), HEXA(5), HEXB(1), LCT(5), MAN2B1(1), MAN2B2(3), MAN2C1(6), MANBA(2), NEU1(1)	23494409	32	30	32	7	3	4	3	15	7	0	0.251	1.000	1.000
340	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(1), SRP68(2), SRP72(3), SRP9(1), SRPR(1)	8940101	8	7	8	5	1	2	1	3	1	0	0.907	1.000	1.000
341	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	13	CHUK(2), IKBKAP(3), IKBKB(3), MAP3K1(8), NFKB1(1), NFKBIA(1), RELA(7), TNFAIP3(2), TRAF3(1), TRAF6(2)	22031198	30	27	27	6	1	6	0	8	14	1	0.559	1.000	1.000
342	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(9), APOBEC1(2), APOBEC3B(1), APOBEC3G(1), APOBEC4(1)	8647515	14	13	14	9	3	0	5	5	1	0	0.954	1.000	1.000
343	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CCR5(1), CD2(2), CD3E(1), CD3G(2), CD4(10), IFNG(2), IL12RB1(3), IL12RB2(3), JAK2(7), STAT4(2), TYK2(7)	17396389	40	38	33	10	3	1	6	13	16	1	0.836	1.000	1.000
344	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(2), AGT(4), AGTR2(1), EDNRB(3), EGF(5), EGFR(10), FOS(1), HRAS(1), JUN(2), MYC(1), NFKB1(1), PLCG1(3), PRKCA(3), RELA(7)	23987538	44	40	38	10	5	4	5	13	16	1	0.542	1.000	1.000
345	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ALDH1A1(1), ALDH1A2(1), ALDH1A3(4), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ALDH3B1(3), ALDH3B2(2), AOC2(5), AOC3(1), ASPA(1), CNDP1(4), DDC(3), HAL(1), HARS(1), HDC(1), HNMT(1), MAOA(2), MAOB(3), PRPS1(1), PRPS2(4)	28576177	49	47	46	10	5	8	8	16	12	0	0.138	1.000	1.000
346	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	B3GNT1(2), B3GNT2(4), B3GNT3(1), B3GNT5(1), B4GALT1(2), B4GALT2(1), B4GALT3(2), B4GALT4(2), FUT2(1), FUT3(2), FUT4(3), FUT5(1), FUT6(4), GCNT2(5), ST8SIA1(2)	17993869	33	30	32	9	5	6	4	9	9	0	0.532	1.000	1.000
347	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	26	AKT1(1), APC(11), AXIN1(5), CTNNB1(4), DVL1(1), FZD1(2), GNAI1(3), GSK3B(3), IRAK1(3), LBP(1), LEF1(3), LY96(1), NFKB1(1), PIK3CA(16), PIK3R1(5), PPP2CA(1), RELA(7), TLR4(2), WNT1(2)	35721269	72	68	61	14	5	16	5	26	19	1	0.105	1.000	1.000
348	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	ACVR1(1), APC(11), ATF2(3), AXIN1(5), BMP10(1), BMP2(1), BMP4(2), BMP5(1), BMP7(5), BMPR1A(2), BMPR2(6), CHRD(5), CTNNB1(4), DVL1(1), FZD1(2), GATA4(2), GSK3B(3), MAP3K7(3), MEF2C(1), MYL2(1), NKX2-5(1), NOG(1), NPPA(1), NPPB(1), RFC1(4), TGFB2(2), TGFBR1(1), TGFBR2(1), TGFBR3(3), WNT1(2)	42239001	77	66	75	13	9	7	7	33	21	0	0.0471	1.000	1.000
349	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	25	GHR(1), GRB2(3), HRAS(1), INS(1), INSR(4), IRS1(6), JAK2(7), MAPK1(1), MAPK3(3), PIK3CA(16), PIK3R1(5), PLCG1(3), PRKCA(3), PTPN6(3), RAF1(5), RPS6KA1(7), SHC1(4), SLC2A4(3), SOCS1(1), SOS1(7), STAT5A(4), STAT5B(4)	38746384	92	81	78	19	10	16	11	29	25	1	0.175	1.000	1.000
350	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(9), C5(7), C6(3), C7(4), ICAM1(3), ITGA4(3), ITGAL(6), ITGB1(6), ITGB2(2), SELP(2), SELPLG(3), TNF(1), VCAM1(5)	29178988	54	51	54	12	4	8	8	24	10	0	0.234	1.000	1.000
351	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(7), ATP5E(1), ATP6AP1(4), ATP6V0A1(5), ATP6V0A4(3), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(5), ATP6V1B1(4), ATP6V1B2(5), ATP6V1C1(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1G1(1), ATP6V1H(1), ATP7A(6), ATP7B(9), COX10(5), COX5A(1), COX7A1(2), COX7C(1), COX8A(1), NDUFA1(1), NDUFA10(1), NDUFB2(1), NDUFB4(2), NDUFB5(2), NDUFB6(1), NDUFB7(1), NDUFS1(8), NDUFS2(1), NDUFV1(2), NDUFV2(1), PPA2(2), SDHA(8), SDHB(1), SHMT1(4), UQCRC1(2), UQCRFS1(2)	45252283	107	94	106	22	7	15	21	40	23	1	0.0819	1.000	1.000
352	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	ATF2(3), BCR(2), BLNK(1), ELK1(2), FOS(1), GRB2(3), HRAS(1), JUN(2), LYN(3), MAP3K1(8), MAPK1(1), MAPK3(3), MAPK8IP3(1), PAPPA(5), RPS6KA1(7), RPS6KA3(2), SHC1(4), SOS1(7), SYK(2), VAV1(6), VAV2(4), VAV3(2)	37319224	70	63	66	13	8	11	7	30	13	1	0.0764	1.000	1.000
353	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOA(2), ALDOB(5), GOT1(3), GOT2(3), GPT(4), GPT2(2), MDH1(1), MDH2(1), ME1(1), ME3(2), PGK1(3), PGK2(1), PKLR(1), RPE(2), RPIA(3), TKT(3), TKTL1(2), TKTL2(4), TPI1(1)	23560559	44	42	43	10	2	7	6	10	19	0	0.464	1.000	1.000
354	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(1), HK1(7), IMPA1(1), IMPA2(3), PGM1(1)	13618439	13	12	13	9	3	1	0	4	5	0	0.980	1.000	1.000
355	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM2(1), CAMK1(3), CAMK1G(4), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CAMK4(3), HDAC5(3), MEF2A(2), MEF2C(1), MEF2D(1), PPP3CA(2), PPP3CB(1), PPP3CC(3), SLC2A4(3), SYT1(1)	24266643	36	36	35	9	6	3	5	13	9	0	0.350	1.000	1.000
356	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	ARFIP2(1), CFL1(1), CHN1(2), LIMK1(6), MAP3K1(8), MYL2(1), MYLK(5), NCF2(2), PAK1(4), PDGFRA(6), PIK3CA(16), PIK3R1(5), PLD1(3), PPP1R12B(3), RALBP1(3), RPS6KB1(2), TRIO(8), VAV1(6), WASF1(1)	41295663	83	77	75	16	7	14	7	32	23	0	0.153	1.000	1.000
357	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ALDH1A3(4), ALDH3B1(3), ALDH3B2(2), AOC2(5), AOC3(1), DDC(3), EPX(2), GOT1(3), GOT2(3), HPD(1), LPO(2), MAOA(2), MAOB(3), MPO(5), PRDX1(1), PRDX5(2), PRDX6(2), TAT(3), TPO(4)	25647748	51	47	48	12	5	6	11	11	18	0	0.348	1.000	1.000
358	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(4), AGTR2(1), CALM2(1), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), F2(4), FYN(2), GNAI1(3), GNB1(3), GRB2(3), HRAS(1), JAK2(7), MAP2K2(1), MAPK1(1), MAPK14(2), MAPK3(3), MAPT(5), MYLK(5), PLCG1(3), PRKCA(3), PTK2B(4), RAF1(5), SHC1(4), SOS1(7), STAT1(6), STAT3(4), STAT5A(4), SYT1(1)	49429298	95	84	93	17	9	13	11	38	24	0	0.0755	1.000	1.000
359	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARF1(1), ARFGAP1(1), ARFGAP3(2), ARFGEF2(10), CLTA(2), CLTB(2), COPA(7), GBF1(14), GPLD1(2), KDELR3(7)	19261245	48	45	48	12	3	2	6	20	15	2	0.569	1.000	1.000
360	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	AKT1(1), BCR(2), FOS(1), GRB2(3), HRAS(1), JAK2(7), JUN(2), MAP3K1(8), MAPK3(3), MYC(1), PIK3CA(16), PIK3R1(5), RAF1(5), SOS1(7), STAT1(6), STAT5A(4), STAT5B(4)	32620461	76	71	69	16	6	14	8	32	16	0	0.191	1.000	1.000
361	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	19	APAF1(4), BAX(1), BID(2), BIK(2), BIRC2(3), BIRC3(6), CASP6(1), CASP7(1), CASP8(1), CASP9(2), DFFA(1), DFFB(1)	15962158	25	25	25	7	0	3	4	12	6	0	0.582	1.000	1.000
362	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	AKT1(1), CREB1(1), GRB2(3), HRAS(1), MAPK1(1), MAPK3(3), MAPK7(1), MEF2A(2), MEF2C(1), MEF2D(1), NTRK1(6), PIK3CA(16), PIK3R1(5), PLCG1(3), RPS6KA1(7), SHC1(4)	22591278	56	51	44	13	7	11	4	20	13	1	0.265	1.000	1.000
363	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	38	AKT1(1), ATF2(3), CDC42(1), DLD(4), DUSP10(1), DUSP4(1), DUSP8(1), GAB1(1), GCK(1), IL1R1(3), JUN(2), MAP2K5(3), MAP2K7(3), MAP3K1(8), MAP3K10(4), MAP3K11(1), MAP3K12(5), MAP3K13(2), MAP3K2(2), MAP3K3(3), MAP3K4(9), MAP3K5(5), MAP3K7(3), MAP3K9(4), MAPK10(2), MAPK7(1), MAPK9(2), NFATC3(8), NR2C2(1), PAPPA(5), SHC1(4), TP53(50), TRAF6(2), ZAK(5)	58729559	151	124	139	29	11	16	17	57	45	5	0.0508	1.000	1.000
364	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	AGXT(2), AGXT2(1), AKR1B10(2), ALAS1(5), ALAS2(3), AMT(1), AOC2(5), AOC3(1), BHMT(5), CBS(1), CHDH(4), CHKB(2), CTH(2), DAO(1), DLD(4), DMGDH(4), GATM(2), GLDC(4), GNMT(1), MAOA(2), MAOB(3), PHGDH(3), PIPOX(3), PISD(1), PSAT1(2), RDH11(4), RDH12(3), RDH13(1), SARDH(4), SARS(2), SHMT1(4), SHMT2(6), TARS(6), TARS2(5)	50341370	99	91	95	19	11	14	14	31	28	1	0.0437	1.000	1.000
365	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	CAD(13), CANT1(1), DCK(1), DCTD(1), DPYD(5), DPYS(3), DTYMK(1), DUT(1), NT5C(1), NT5M(3), NUDT2(1), POLB(2), POLD1(8), POLD2(1), POLE(6), POLG(6), POLL(3), POLQ(12), POLR1B(4), POLR2A(11), POLR2B(6), POLR2C(1), POLR2D(1), POLR2F(4), POLR2I(1), POLR2K(1), POLRMT(5), RRM1(4), RRM2(1), TK1(1), TK2(2), TXNRD1(1), UCK1(1), UCK2(1), UMPS(3), UNG(2), UPB1(2), UPP1(3)	67454276	124	102	116	20	8	14	17	35	48	2	0.0236	1.000	1.000
366	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	62	AKT1(1), AKT2(4), AKT3(2), CDC42(1), CDK2(2), CDKN1B(1), CDKN2A(4), CREB1(1), CREB5(3), ERBB4(11), F2RL2(2), GAB1(1), GRB2(3), GSK3A(1), GSK3B(3), IGFBP1(1), INPPL1(4), IRS1(6), IRS4(1), MET(28), MYC(1), NOLC1(2), PAK1(4), PAK2(4), PAK3(2), PAK4(5), PAK6(4), PAK7(3), PARD3(7), PDK1(1), PIK3CA(16), PIK3CD(2), PPP1R13B(6), PREX1(9), PTEN(35), PTK2(3), PTPN1(2), RPS6KA1(7), RPS6KA3(2), RPS6KB1(2), SFN(1), SHC1(4), SLC2A4(3), SOS1(7), SOS2(7), TSC1(5), TSC2(14), YWHAB(1)	88587512	239	193	215	38	19	39	30	69	74	8	0.000349	1.000	1.000
367	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	24	ATM(23), BMPR1B(1), CCND2(1), CDK4(7), CDKN1B(1), DAZL(1), DMC1(1), EGR1(10), ESR2(5), FSHR(2), GJA4(1), LHCGR(1), MLH1(5), NCOR1(11), NR5A1(1), NRIP1(6), PGR(4), PRLR(3), PTGER2(1), SMPD1(5), VDR(2), ZP2(5)	40354319	97	85	84	21	11	11	9	33	32	1	0.287	1.000	1.000
368	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(11), AXIN1(5), CREBBP(13), CTNNB1(4), DVL1(1), EP300(16), FZD1(2), GSK3B(3), HDAC1(2), LDB1(2), LEF1(3), PITX2(2), TRRAP(13), WNT1(2)	38598774	79	70	70	17	5	5	12	31	26	0	0.313	1.000	1.000
369	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(4), ACAD8(1), ACAD9(2), ADH1A(2), ADH1B(2), ADH4(1), ADH5(1), ADH6(3), ADHFE1(3), AKR1B10(2), AKR1C4(1), ALDH1A3(4), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ALDH7A1(1), BAAT(2), CEL(2), CYP27A1(2), CYP7A1(1), HADHB(4), LIPA(1), RDH11(4), RDH12(3), RDH13(1), SLC27A5(3), SOAT1(5), SOAT2(2), SRD5A1(1)	37421934	68	65	62	14	6	4	6	32	20	0	0.294	1.000	1.000
370	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	CREBBP(13), EP300(16), FYN(2), IL7R(1), JAK1(6), JAK3(4), LCK(1), PIK3CA(16), PIK3R1(5), PTK2B(4), STAT5A(4), STAT5B(4)	33010067	76	69	66	17	5	14	13	21	23	0	0.219	1.000	1.000
371	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(1), ACTR2(2), ACTR3(1), ARPC1B(1), ARPC2(8), NCK1(1), NCKAP1(2), NTRK1(6), PSMA7(1), WASF1(1), WASF2(2), WASF3(2), WASL(9)	17937292	37	34	30	10	1	5	3	15	13	0	0.529	1.000	1.000
372	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	ABAT(2), ACADS(3), ACAT1(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(4), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ECHS1(3), EHHADH(6), GAD1(2), GAD2(3), HADHA(4), HMGCL(2), L2HGDH(1), OXCT1(2), PDHA1(1), PDHA2(3), PDHB(1), SDHB(1)	30441864	51	50	47	11	7	7	10	14	13	0	0.150	1.000	1.000
373	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(3), POLB(2), POLD1(8), POLD2(1), POLD3(1), POLE(6), POLE2(1), POLG(6), POLG2(5), POLH(4), POLI(4), POLK(5), POLL(3), POLM(6), POLQ(12), PRIM1(2), PRIM2(2), REV1(5), REV3L(15), RFC5(2)	48565324	93	79	87	16	5	10	6	44	28	0	0.146	1.000	1.000
374	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	37	ANPEP(11), G6PD(2), GCLC(4), GCLM(1), GGT1(4), GPX6(1), GSR(2), GSS(1), GSTA1(2), GSTA2(1), GSTA3(1), GSTA4(1), GSTA5(1), GSTK1(2), GSTM1(2), GSTM2(1), GSTM4(1), GSTM5(1), GSTT1(1), IDH1(2), IDH2(6), OPLAH(4), TXNDC12(2)	26240822	54	45	51	12	2	4	16	19	13	0	0.246	1.000	1.000
375	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(11), EIF4E(2), FBL(2), GPT(4), LDHB(1), LDHC(3), MAPK14(2), NCL(7)	10521056	32	29	31	10	0	1	11	11	9	0	0.681	1.000	1.000
376	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(13), EP300(16), LPL(6), NCOA1(5), NCOA2(13), PPARG(3), RXRA(2)	21621825	58	50	49	16	4	8	7	12	27	0	0.556	1.000	1.000
377	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(11), CDH1(3), CREBBP(13), EP300(16), MAP3K7(3), MAPK3(3), SKIL(3), TGFB2(2), TGFBR1(1), TGFBR2(1)	30285983	56	52	53	12	3	4	13	18	18	0	0.247	1.000	1.000
378	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ALDH1A3(4), ALDH3B1(3), ALDH3B2(2), AOC2(5), AOC3(1), DDC(3), EPX(2), ESCO1(4), ESCO2(1), GOT1(3), GOT2(3), HPD(1), LPO(2), MAOA(2), MAOB(3), MPO(5), PNPLA3(3), PRDX6(2), SH3GLB1(3), TAT(3), TPO(4)	39881575	59	55	56	11	5	8	11	14	21	0	0.136	1.000	1.000
379	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	18	CHUK(2), IKBKAP(3), IKBKB(3), LTA(1), MAP3K1(8), NFKB1(1), NFKBIA(1), RELA(7), RIPK1(2), TANK(1), TNFAIP3(2), TNFRSF1B(2), TRAF2(1), TRAF3(1)	26848456	35	31	32	9	2	6	1	11	14	1	0.683	1.000	1.000
380	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	34	AKT1(1), CBL(2), CFLAR(3), E2F1(1), FOS(1), GRB2(3), HRAS(1), IL2RA(2), IL2RB(2), IRS1(6), JAK1(6), JAK3(4), MAPK1(1), MAPK3(3), MYC(1), PIK3CA(16), PIK3R1(5), PPIA(1), PTPN6(3), RAF1(5), RPS6KB1(2), SHC1(4), SOCS1(1), SOCS3(2), SOS1(7), STAT5A(4), STAT5B(4), SYK(2)	41897229	93	85	86	20	11	19	14	26	23	0	0.0753	1.000	1.000
381	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	33	MAP2K7(3), MAPK1(1), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(2), MAPK3(3), MAPK8IP1(4), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIB(2), NFKBIL1(2), PIK3CA(16), PIK3CD(2), PIK3R1(5), SYT1(1), TRAF2(1), TRAF3(1), TRAF5(4), TRAF6(2)	39651490	63	58	57	12	11	14	4	26	8	0	0.0393	1.000	1.000
382	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(2), ALOX12(5), ALOX5(4), CBR1(3), CYP4F2(5), CYP4F3(3), EPX(2), GGT1(4), LPO(2), LTA4H(4), MPO(5), PLA2G4A(2), PLA2G6(5), PRDX1(1), PRDX5(2), PRDX6(2), PTGDS(1), PTGS1(2), PTGS2(5), TBXAS1(4), TPO(4)	32741552	67	62	65	15	6	8	14	22	16	1	0.239	1.000	1.000
383	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(2), ACACA(8), ACADL(3), ACADM(3), ACADSB(1), ACAT1(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(4), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ALDH6A1(1), ECHS1(3), EHHADH(6), HADHA(4), LDHB(1), LDHC(3), MCEE(1), MLYCD(3), MUT(2), PCCA(2), PCCB(4), SUCLA2(2), SUCLG1(6), SUCLG2(2)	39207224	74	69	70	16	5	8	17	24	19	1	0.182	1.000	1.000
384	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(5), DIAPH1(7), FYN(2), GSN(4), HRAS(1), ITGA1(8), ITGB1(6), MAPK1(1), MAPK3(3), MYL2(1), MYLK(5), PFN1(1), PIK3CA(16), PIK3R1(5), PTK2(3), PXN(3), RAF1(5), ROCK1(7), SHC1(4), SRC(2), TLN1(12)	44083344	101	88	94	21	9	18	8	36	30	0	0.140	1.000	1.000
385	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT1(1), AKT2(4), AKT3(2), CISH(2), GRB2(3), IARS(4), IL13RA1(2), IL4(1), IL4R(5), INPP5D(2), JAK1(6), JAK2(7), JAK3(4), PI3(1), PIK3CA(16), PPP1R13B(6), RPS6KB1(2), SHC1(4), SOS1(7), SOS2(7), SRC(2), STAT6(4), TYK2(7)	43084286	99	84	92	21	7	20	17	34	21	0	0.0734	1.000	1.000
386	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(3), ALG5(1), B4GALT1(2), B4GALT2(1), B4GALT3(2), B4GALT5(3), DPAGT1(8), DPM1(1), MAN1A1(2), MAN1B1(2), MGAT4A(3), MGAT4B(2), MGAT5(4), RPN1(4), RPN2(2), ST6GAL1(1)	23022326	41	40	41	10	1	9	1	13	17	0	0.534	1.000	1.000
387	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(1), AKT1(1), BDKRB2(1), CALM2(1), CHRM1(2), CHRNA1(2), FLT1(8), FLT4(15), KDR(6), NOS3(3), PDE2A(1), PDE3A(5), PDE3B(3), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4), PRKG1(5), PRKG2(4), RYR2(16), SLC7A1(3), SYT1(1), TNNI1(2)	48449080	92	83	92	19	16	16	8	32	20	0	0.0507	1.000	1.000
388	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ACY3(1), ALDH1A3(4), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ALDH3B1(3), ALDH3B2(2), ALDH7A1(1), AMDHD1(2), AOC2(5), AOC3(1), ASPA(1), CNDP1(4), DDC(3), FTCD(3), HAL(1), HARS(1), HARS2(1), HDC(1), HNMT(1), LCMT1(1), LCMT2(4), MAOA(2), MAOB(3), METTL2B(1), PRMT2(1), PRMT3(2), PRMT5(5), PRMT6(2), PRMT7(3), PRMT8(3), PRPS1(1), PRPS2(4), UROC1(2)	46326109	79	70	76	15	7	13	13	27	19	0	0.0614	1.000	1.000
389	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA3(2), PSMA4(2), PSMA6(4), PSMA7(1), PSMB1(1), PSMB4(1), PSMB5(2), PSMB6(1), PSMB7(1), PSMC2(3), PSMC3(1), PSMD1(3), PSMD11(3), PSMD12(2), PSMD13(3), PSMD2(8), PSMD6(2)	19030475	40	36	39	10	1	3	5	15	16	0	0.679	1.000	1.000
390	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM2(1), CCL2(1), CCR5(1), CXCR4(1), FOS(1), JUN(2), MAPK14(2), PLCG1(3), PRKCA(3), PTK2B(4), SYT1(1)	16069405	20	19	19	9	2	4	2	7	5	0	0.933	1.000	1.000
391	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(11), CD2(2), CD33(4), CD5(2), CD7(2), IFNA1(1), IFNB1(2), IFNG(2), IL3(1), IL4(1), ITGAX(10), TLR2(3), TLR4(2), TLR7(5), TLR9(1)	21545439	49	45	48	14	5	6	12	12	14	0	0.371	1.000	1.000
392	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	ADCY1(2), ARHGEF1(2), F2(4), F2R(2), F2RL3(1), GNA12(1), GNA13(6), GNAI1(3), GNB1(3), MAP3K7(3), PIK3CA(16), PIK3R1(5), PLCB1(3), PPP1R12B(3), PRKCA(3), PTK2B(4), ROCK1(7)	30188462	68	63	62	16	9	13	4	26	16	0	0.296	1.000	1.000
393	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AADAC(1), ABAT(2), ACADS(3), ACAT1(1), ACSM1(2), AKR1B10(2), ALDH1A3(4), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ALDH7A1(1), BDH1(1), BDH2(1), DDHD1(3), ECHS1(3), EHHADH(6), GAD1(2), GAD2(3), HADH(1), HADHA(4), HMGCL(2), HMGCS1(4), HMGCS2(3), HSD17B4(1), ILVBL(5), L2HGDH(1), OXCT1(2), PDHA1(1), PDHA2(3), PDHB(1), PLA1A(4), PRDX6(2), RDH11(4), RDH12(3), RDH13(1)	48158232	87	80	83	18	9	11	13	30	24	0	0.116	1.000	1.000
394	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), DAG1(3), ITPKA(1), ITPKB(3), ITPR1(11), ITPR2(14), ITPR3(7), NFAT5(9), PDE6A(2), PDE6B(6), PDE6C(2), SLC6A13(7), TF(1)	42372108	74	68	74	16	7	8	17	27	15	0	0.163	1.000	1.000
395	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(2), CREBBP(13), EP300(16), IKBKB(3), IL1B(1), MAP2K3(3), MAP3K7(3), MAPK11(1), MAPK14(2), NFKB1(1), NFKBIA(1), NR3C1(4), RELA(7), TGFBR1(1), TGFBR2(1), TLR2(3), TNF(1)	34785504	63	56	57	14	3	7	8	17	27	1	0.535	1.000	1.000
396	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ADH1A(2), ADH1B(2), ADH4(1), ADH6(3), ADHFE1(3), ALDH1A3(4), ALDH3B1(3), ALDH3B2(2), AOC2(5), AOC3(1), AOX1(8), COMT(1), DBH(2), DCT(5), DDC(3), FAH(1), GOT1(3), GOT2(3), HGD(2), HPD(1), MAOA(2), MAOB(3), TAT(3), TH(4), TPO(4), TYR(5)	37027990	76	69	72	20	10	7	9	26	24	0	0.490	1.000	1.000
397	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	22	ADCY1(2), AKT1(1), BAX(1), CSF2RB(7), IGF1R(4), IL3(1), KITLG(2), PIK3CA(16), PIK3R1(5), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4)	25583271	51	49	45	14	9	11	3	19	9	0	0.248	1.000	1.000
398	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(1), ACAD9(2), ADH1A(2), ADH1B(2), ADH4(1), ADH5(1), ADH6(3), ADHFE1(3), DHRS2(1), DHRSX(5), ESCO1(4), ESCO2(1), PNPLA3(3), SH3GLB1(3)	29324110	32	29	27	7	1	4	2	13	12	0	0.642	1.000	1.000
399	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(1), ALG10(3), ALG10B(8), ALG11(5), ALG12(2), ALG13(4), ALG14(2), ALG2(1), ALG3(3), ALG5(1), ALG6(3), ALG8(1), ALG9(3), B4GALT1(2), B4GALT2(1), B4GALT3(2), DHDDS(1), DOLPP1(3), DPAGT1(8), DPM1(1), MAN1A1(2), MAN1A2(1), MAN1B1(2), MAN1C1(2), MAN2A1(5), MGAT4A(3), MGAT4B(2), MGAT5(4), MGAT5B(4), RPN1(4), RPN2(2), ST6GAL1(1), STT3B(4)	49761174	91	77	90	18	3	17	6	31	34	0	0.196	1.000	1.000
400	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM2(1), DLG4(1), GRIN1(2), GRIN2A(10), GRIN2B(8), GRIN2D(3), NOS1(10), PPP3CA(2), PPP3CB(1), PPP3CC(3), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4), PRKCA(3), SYT1(1)	30018132	57	52	56	15	9	8	6	25	9	0	0.293	1.000	1.000
401	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CREB1(1), CREBBP(13), EP300(16), NCOA3(8), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4), RARA(4), RXRA(2)	24157141	56	54	53	16	3	6	11	17	19	0	0.474	1.000	1.000
402	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(8), CD38(1), ENPP1(2), ENPP3(2), NADK(1), NADSYN1(1), NMNAT2(3), NMNAT3(2), NNMT(1), NNT(9), NT5C(1), NT5C1A(3), NT5C1B(2), NT5C2(1), NT5M(3), NUDT12(2), QPRT(1)	25362589	43	42	43	12	5	5	4	21	8	0	0.560	1.000	1.000
403	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(2), ACTR3(1), ARHGAP1(1), ARHGAP5(5), ARHGAP6(3), ARHGEF1(2), ARHGEF11(6), ARHGEF5(4), ARPC1B(1), ARPC2(8), BAIAP2(3), CFL1(1), DIAPH1(7), GSN(4), LIMK1(6), MYL2(1), MYLK(5), OPHN1(2), PFN1(1), PIP5K1A(2), PPP1R12B(3), ROCK1(7), SRC(2), TLN1(12), VCL(3)	54402062	92	81	83	17	4	9	8	28	43	0	0.228	1.000	1.000
404	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	ACHE(1), CHAT(5), COMT(1), DBH(2), DDC(3), GAD1(2), GAD2(3), HDC(1), MAOA(2), PAH(5), SLC18A3(2), TH(4), TPH1(3)	16415602	34	32	32	11	3	5	8	9	9	0	0.694	1.000	1.000
405	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(2), AGT(4), AGTR1(2), AGTR2(1), CMA1(2), COL4A1(4), COL4A2(4), COL4A3(7), COL4A4(3), COL4A5(8), COL4A6(6), REN(1)	30108508	44	42	44	13	5	15	4	13	7	0	0.388	1.000	1.000
406	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ACY1(3), AGMAT(2), ALDH18A1(2), ALDH1A3(4), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ALDH7A1(1), AMD1(2), AOC2(5), AOC3(1), ARG1(2), ARG2(1), ASL(4), ASS1(2), CPS1(5), GATM(2), MAOA(2), MAOB(3), NAGS(1), ODC1(3), OTC(1), SAT1(1), SAT2(1), SMS(2)	34487137	60	60	58	15	4	6	10	20	20	0	0.459	1.000	1.000
407	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(5), EGFR(10), MAP3K1(8), MAPK14(2), NCOR2(7), RARA(4), RXRA(2), THRA(2)	20230386	40	34	37	11	2	6	7	13	12	0	0.646	1.000	1.000
408	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(1), COASY(2), DPYD(5), DPYS(3), ENPP1(2), ENPP3(2), ILVBL(5), PANK1(4), PANK2(5), PANK3(2), PANK4(1), PPCDC(1), UPB1(2), VNN1(1)	20256946	36	35	36	11	3	4	6	11	12	0	0.670	1.000	1.000
409	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(1), ASNS(2), CA1(1), CA12(1), CA14(4), CA5B(1), CA6(1), CA7(1), CA9(1), CPS1(5), CTH(2), GLS(9), GLS2(4), GLUD1(1), GLUL(2), HAL(1)	22294428	37	36	37	10	1	4	6	20	6	0	0.603	1.000	1.000
410	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	AKT1(1), AKT2(4), AKT3(2), BCR(2), BLNK(1), CD19(1), CSK(4), DAG1(3), EPHB2(3), GRB2(3), ITPKA(1), ITPKB(3), LYN(3), MAP2K2(1), MAPK1(1), NFAT5(9), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIB(2), NFKBIL1(2), PI3(1), PIK3CA(16), PIK3CD(2), PIK3R1(5), PLCG2(3), PPP1R13B(6), RAF1(5), SHC1(4), SOS1(7), SOS2(7), SYK(2), VAV1(6)	61202636	115	102	109	22	13	22	16	44	20	0	0.0146	1.000	1.000
411	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BAX(1), CASP8(1), MAP3K1(8), MAPK1(1), MAPK3(3), NFKB1(1), NSMAF(6), RAF1(5), RELA(7), RIPK1(2), SMPD1(5), TNFRSF1A(1), TRADD(2), TRAF2(1)	23980385	44	38	39	12	6	5	6	12	14	1	0.584	1.000	1.000
412	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(2), ARG1(2), ARG2(1), ASL(4), ASS1(2), CKB(1), CKMT1B(1), CPS1(5), DAO(1), EPRS(3), GATM(2), GLUD1(1), GLUD2(1), GOT1(3), GOT2(3), LAP3(4), NOS1(10), NOS3(3), OAT(3), OTC(1), P4HA1(4), P4HA2(1), P4HA3(2), PARS2(4), PRODH(2), PYCR1(1), PYCR2(3), PYCRL(2), RARS(4), RARS2(2)	42627273	78	69	78	17	7	7	16	25	23	0	0.239	1.000	1.000
413	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	20	CSNK2A1(3), ELK1(2), FOS(1), GRB2(3), HRAS(1), IL6R(2), IL6ST(5), JAK1(6), JAK2(7), JAK3(4), JUN(2), MAPK3(3), PTPN11(1), RAF1(5), SHC1(4), SOS1(7), STAT3(4)	27759968	60	56	60	16	5	8	11	24	12	0	0.486	1.000	1.000
414	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(1), ASNS(2), ASRGL1(4), CA1(1), CA12(1), CA13(2), CA14(4), CA5B(1), CA6(1), CA7(1), CA9(1), CPS1(5), CTH(2), GLS(9), GLS2(4), GLUD1(1), GLUD2(1), GLUL(2), HAL(1)	24874778	44	43	41	12	2	5	6	21	10	0	0.610	1.000	1.000
415	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	CALM2(1), CD3E(1), CD3G(2), ELK1(2), FOS(1), FYN(2), GRB2(3), HRAS(1), JUN(2), LCK(1), MAP3K1(8), MAPK3(3), NFATC1(4), NFATC2(6), NFATC3(8), NFATC4(3), NFKB1(1), NFKBIA(1), PIK3CA(16), PIK3R1(5), PLCG1(3), PPP3CA(2), PPP3CB(1), PPP3CC(3), PRKCA(3), PTPN7(1), RAF1(5), RASA1(7), RELA(7), SHC1(4), SOS1(7), SYT1(1), VAV1(6), ZAP70(1)	55597960	122	108	110	27	12	26	11	36	36	1	0.201	1.000	1.000
416	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	64	ATM(23), CCNA1(7), CCND2(1), CCND3(1), CCNE1(1), CCNE2(4), CCNG2(2), CCNH(1), CDC25A(2), CDK2(2), CDK4(7), CDKN1A(3), CDKN1B(1), CDKN2A(4), CDKN2C(1), CREB3L1(3), CREB3L3(1), CREB3L4(3), E2F1(1), E2F2(1), E2F3(1), E2F5(2), GBA2(6), MCM2(9), MCM3(2), MCM4(1), MCM5(3), MCM6(6), MCM7(5), MNAT1(1), MYC(1), MYT1(9), NACA(11), PCNA(3), POLE(6), POLE2(1), PRIM1(2), RB1(4), RPA1(2), RPA2(2), RPA3(1), TFDP2(5), TNXB(11), TP53(50), WEE1(2)	89390237	215	155	191	38	20	27	22	62	77	7	0.00288	1.000	1.000
417	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	31	ANPEP(11), G6PD(2), GCLC(4), GCLM(1), GGT1(4), GSS(1), GSTA1(2), GSTA2(1), GSTA3(1), GSTA4(1), GSTM1(2), GSTM2(1), GSTM4(1), GSTM5(1), GSTT1(1), IDH1(2), IDH2(6), PGD(1)	21893256	43	37	40	12	2	3	15	12	11	0	0.516	1.000	1.000
418	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(5), ADRBK2(1), ARRB2(1), CALM2(1), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CLCA1(3), CLCA4(2), CNGA3(4), CNGA4(2), CNGB1(8), GUCA1B(1), PDC(1), PDE1C(3), PRKACA(1), PRKACB(2), PRKACG(3), PRKG1(5), PRKG2(4), PRKX(2)	36410808	57	55	54	14	6	11	3	26	11	0	0.332	1.000	1.000
419	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(2), AASDHPPT(3), AASS(9), ACAT1(1), AKR1B10(2), ALDH1A3(4), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ALDH7A1(1), BBOX1(1), DOT1L(8), ECHS1(3), EHHADH(6), EHMT1(4), EHMT2(8), GCDH(5), HADH(1), HADHA(4), HSD17B4(1), NSD1(12), OGDH(8), OGDHL(3), PIPOX(3), PLOD1(3), PLOD2(7), PLOD3(12), RDH11(4), RDH12(3), RDH13(1), SETD1A(9), SETD7(1), SETDB1(8), SHMT1(4), SHMT2(6), SPCS1(2), SPCS3(1), SUV39H1(1), SUV39H2(5), TMLHE(1)	67274737	167	133	154	30	12	26	23	53	51	2	0.0208	1.000	1.000
420	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(2), ALOX12(5), ALOX12B(2), ALOX15B(4), ALOX5(4), CBR1(3), CYP2B6(1), CYP2C18(3), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP2E1(1), CYP2J2(4), CYP2U1(1), CYP4A11(6), CYP4F2(5), CYP4F3(3), DHRS4(4), EPHX2(2), GGT1(4), GPX6(1), LTA4H(4), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(5), PTGDS(1), PTGES(1), PTGS1(2), PTGS2(5), TBXAS1(4)	46092757	85	75	83	19	8	9	17	26	23	2	0.218	1.000	1.000
421	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(2), CD28(1), CSK(4), CTLA4(1), DAG1(3), DTYMK(1), EPHB2(3), FBXW7(5), GRAP2(1), GRB2(3), ITK(2), ITPKA(1), ITPKB(3), LCK(1), LCP2(2), MAPK1(1), NCK1(1), NFAT5(9), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIB(2), NFKBIL1(2), PAK1(4), PAK2(4), PAK3(2), PAK4(5), PAK6(4), PAK7(3), PLCG1(3), PTPRC(7), RAF1(5), RASGRP1(3), RASGRP2(2), RASGRP3(2), RASGRP4(4), SOS1(7), SOS2(7), VAV1(6), ZAP70(1)	65679431	122	105	121	25	14	15	20	43	30	0	0.0770	1.000	1.000
422	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	59	ALG2(1), BAX(1), BFAR(2), CAD(13), CASP10(3), CASP8(1), CD7(2), CSNK1A1(2), DAXX(6), DEDD(2), DFFA(1), EGFR(10), EPHB2(3), FAF1(1), FAIM2(1), MAP2K7(3), MAP3K1(8), MAP3K5(5), MAPK1(1), MAPK10(2), MAPK8IP1(4), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2), MET(28), NFAT5(9), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIB(2), NFKBIL1(2), PFN1(1), PTPN13(10), RALBP1(3), RIPK1(2), ROCK1(7), SMPD1(5), TP53(50), TPX2(2), TRAF2(1)	86134889	203	161	176	35	22	24	26	76	50	5	0.00215	1.000	1.000
423	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(1), ACP2(2), ACP5(2), ALPI(3), ALPL(4), ALPP(4), ALPPL2(5), CYP19A1(2), CYP1A1(1), CYP1A2(6), CYP2A13(6), CYP2A6(1), CYP2A7(2), CYP2B6(1), CYP2C18(3), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP2D6(4), CYP2E1(1), CYP2F1(4), CYP2J2(4), CYP3A5(1), CYP3A7(2), CYP4B1(3), CYP51A1(2), PON1(1)	34004058	68	58	68	18	13	11	2	28	13	1	0.304	1.000	1.000
424	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(2), ACACA(8), ACACB(5), ACADM(3), ACAT1(1), ACSS1(3), ACSS2(8), ALDH1A3(4), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ALDH6A1(1), ALDH7A1(1), ECHS1(3), EHHADH(6), HADHA(4), LDHAL6B(1), LDHB(1), LDHC(3), MCEE(1), MLYCD(3), MUT(2), PCCA(2), PCCB(4), SUCLA2(2), SUCLG1(6), SUCLG2(2)	46974815	86	75	81	20	5	8	19	25	27	2	0.318	1.000	1.000
425	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(4), COL4A2(4), COL4A3(7), COL4A4(3), COL4A5(8), COL4A6(6), F10(1), F11(2), F12(9), F2(4), F2R(2), F5(11), F8(7), F9(3), FGA(4), FGB(3), FGG(6), KLKB1(2), PROC(3), PROS1(5), SERPING1(2)	52653516	96	85	94	25	13	19	8	29	26	1	0.243	1.000	1.000
426	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(2), GPLD1(2), PGAP1(5), PIGB(1), PIGC(1), PIGG(1), PIGK(2), PIGL(2), PIGM(3), PIGN(2), PIGO(5), PIGP(1), PIGQ(3), PIGS(1), PIGT(6), PIGU(2), PIGV(1), PIGZ(3)	28671173	43	40	39	12	3	7	4	15	13	1	0.634	1.000	1.000
427	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(1), IARS(4), IARS2(6), ILVBL(5), LARS(7), LARS2(2), PDHA1(1), PDHA2(3), PDHB(1), VARS(3), VARS2(6)	20868482	39	34	39	11	3	6	7	13	10	0	0.539	1.000	1.000
428	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT1(1), AKT2(4), AKT3(2), ANKRD6(2), APC(11), AXIN1(5), AXIN2(3), CER1(1), CSNK1A1(2), CTNNB1(4), DACT1(2), DVL1(1), FSTL1(2), GSK3A(1), GSK3B(3), LRP1(15), MVP(4), NKD1(4), NKD2(3), PSEN1(1), PTPRA(5), SENP2(2), WIF1(5)	47158166	83	75	79	19	7	12	10	32	22	0	0.176	1.000	1.000
429	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(11), ASAH1(2), CERK(6), CREB1(1), CREB5(3), DAG1(3), EPHB2(3), FOS(1), ITPKA(1), ITPKB(3), JUN(2), MAP2K7(3), MAPK1(1), MAPK10(2), MAPK8IP1(4), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2)	32858438	50	46	47	13	7	4	7	17	15	0	0.531	1.000	1.000
430	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(2), ARSB(1), FUCA2(1), GALNS(6), GBA(2), GLB1(5), GNS(3), GUSB(5), HEXA(5), HEXB(1), HGSNAT(3), HPSE(2), HPSE2(4), HYAL1(2), HYAL2(2), IDS(2), IDUA(2), LCT(5), MAN2B1(1), MAN2B2(3), MAN2C1(6), MANBA(2), NAGLU(3), NEU1(1), SPAM1(8)	40294545	77	66	77	20	11	11	10	28	17	0	0.184	1.000	1.000
431	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	33	GTF2A1(3), GTF2A2(1), GTF2B(2), GTF2E1(1), GTF2E2(3), GTF2F1(2), GTF2F2(1), GTF2H1(2), GTF2H2(1), GTF2H4(2), GTF2I(3), GTF2IRD1(2), STON1(2), TAF1(7), TAF12(1), TAF1L(7), TAF2(7), TAF4(5), TAF4B(7), TAF5(2), TAF5L(3), TAF6(2), TAF7(2), TAF7L(8), TAF9(1), TAF9B(2), TBPL2(1)	43296524	80	73	76	19	7	13	11	25	24	0	0.190	1.000	1.000
432	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	MRPL13(1), MRPS7(1), RPL10A(3), RPL11(3), RPL13(1), RPL18(2), RPL18A(3), RPL19(1), RPL21(1), RPL22L1(1), RPL24(1), RPL26(1), RPL27(1), RPL28(2), RPL3(2), RPL30(3), RPL31(1), RPL32(1), RPL34(1), RPL35(1), RPL36A(1), RPL36AL(1), RPL37A(1), RPL38(1), RPL3L(3), RPL6(1), RPL7(1), RPL8(1), RPS11(1), RPS13(1), RPS16(1), RPS2(2), RPS20(1), RPS21(2), RPS24(1), RPS26(1), RPS27(1), RPS29(1), RPS3(2), RPS3A(1), RPS4Y1(1), RPS8(1), RPS9(1), RPSA(1)	25781109	60	58	60	14	5	5	8	26	15	1	0.452	1.000	1.000
433	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	27	ADRBK1(1), AKT1(1), AKT2(4), AKT3(2), DAG1(3), ITPKA(1), ITPKB(3), ITPR1(11), ITPR2(14), ITPR3(7), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIB(2), NFKBIL1(2), PDK1(1), PHKA2(5), PIK3CB(6), PITX2(2), PLD1(3), PLD2(5), PLD3(4), VN1R1(1)	53066720	83	72	81	18	9	13	17	25	19	0	0.0587	1.000	1.000
434	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ADH1A(2), ADH1B(2), ADH4(1), ADH5(1), ADH6(3), ADHFE1(3), ALDH1A3(4), ALDH3B1(3), ALDH3B2(2), AOC2(5), AOC3(1), AOX1(8), COMT(1), DBH(2), DCT(5), DDC(3), ECH1(3), ESCO1(4), ESCO2(1), FAH(1), GOT1(3), GOT2(3), HGD(2), HPD(1), LCMT1(1), LCMT2(4), MAOA(2), MAOB(3), METTL2B(1), PNPLA3(3), PRMT2(1), PRMT3(2), PRMT5(5), PRMT6(2), PRMT7(3), PRMT8(3), SH3GLB1(3), TAT(3), TH(4), TPO(4), TYR(5), TYRP1(4)	69431386	117	100	113	25	11	13	17	42	34	0	0.152	1.000	1.000
435	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(4), ADH1A(2), ADH1B(2), ADH4(1), ADH6(3), ADHFE1(3), AKR1C4(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(4), ALDH1B1(3), ALDH2(4), ALDH3A2(3), BAAT(2), CEL(2), CYP27A1(2), CYP7A1(1), HADHB(4), SOAT2(2), SRD5A1(1)	27415383	46	45	42	14	4	2	5	22	13	0	0.802	1.000	1.000
436	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(3), AKR1B10(2), ALDOA(2), ALDOB(5), FPGT(1), FUK(2), GMDS(2), GMPPA(2), GMPPB(1), HK1(7), KHK(5), MPI(2), MTMR1(2), MTMR2(3), MTMR6(1), PFKFB3(4), PFKFB4(1), PFKL(3), PFKM(3), PFKP(3), PGM2(2), PHPT1(1), PMM1(1), RDH11(4), RDH12(3), RDH13(1), SORD(10), TPI1(1)	43868505	77	71	69	19	11	8	11	22	25	0	0.437	1.000	1.000
437	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(5), ARHGEF1(2), GNA12(1), GNA13(6), GNB1(3), MYL2(1), MYLK(5), PLCB1(3), PPP1R12B(3), PRKCA(3), ROCK1(7)	24187672	39	39	39	11	3	3	1	19	13	0	0.774	1.000	1.000
438	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AADAT(2), ACAT1(1), ACMSD(2), ALDH1A3(4), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ALDH7A1(1), AOC2(5), AOC3(1), AOX1(8), CAT(3), CYP1A1(1), CYP1A2(6), CYP1B1(2), DDC(3), ECHS1(3), EHHADH(6), GCDH(5), HAAO(2), HADH(1), HADHA(4), HSD17B4(1), INMT(1), KYNU(3), LCMT1(1), LCMT2(4), LNX1(2), MAOA(2), MAOB(3), METTL2B(1), NFX1(4), OGDH(8), OGDHL(3), PRMT2(1), PRMT3(2), PRMT5(5), PRMT6(2), PRMT7(3), PRMT8(3), TDO2(1), TPH1(3), TPH2(2), WARS(1), WARS2(1)	71060684	127	110	122	27	12	20	23	44	28	0	0.0623	1.000	1.000
439	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(4), ARHGDIB(1), BIRC2(3), BIRC3(6), CASP1(2), CASP10(3), CASP2(1), CASP4(3), CASP6(1), CASP7(1), CASP8(1), CASP9(2), DFFA(1), DFFB(1), LMNA(2), LMNB1(4), LMNB2(2), PRF1(1)	22532667	39	37	39	11	0	8	8	13	10	0	0.496	1.000	1.000
440	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(2), CALM2(1), CREB1(1), ELK1(2), FOS(1), GNAI1(3), GNAS(5), GNB1(3), HRAS(1), JUN(2), MAPK3(3), NFATC1(4), NFATC2(6), NFATC3(8), NFATC4(3), PLCG1(3), PPP3CA(2), PPP3CB(1), PPP3CC(3), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4), PRKCA(3), RAF1(5), RPS6KA3(2), SYT1(1)	40166491	77	69	74	20	9	9	8	26	25	0	0.554	1.000	1.000
441	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	30	AKT1(1), CABIN1(11), CALM2(1), CAMK1(3), CAMK1G(4), HDAC5(3), IGF1R(4), INS(1), INSR(4), MAPK14(2), MAPK7(1), MEF2A(2), MEF2C(1), MEF2D(1), NFATC1(4), NFATC2(6), PIK3CA(16), PIK3R1(5), PPP3CA(2), PPP3CB(1), PPP3CC(3), SYT1(1)	40414314	77	70	66	21	11	13	6	25	22	0	0.381	1.000	1.000
442	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM2(1), CHUK(2), EGR2(1), EGR3(2), MAP3K1(8), MYC(1), NFATC1(4), NFATC2(6), NFKB1(1), NFKBIA(1), PLCG1(3), PPP3CA(2), PPP3CB(1), PPP3CC(3), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4), RELA(7), SYT1(1), VIPR2(1)	32205681	57	51	51	16	6	6	3	16	25	1	0.756	1.000	1.000
443	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(1), CAPN1(2), CAPN2(3), EGF(5), EGFR(10), HRAS(1), ITGA1(8), ITGB1(6), MAPK1(1), MAPK3(3), MYL2(1), MYLK(5), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4), PTK2(3), PXN(3), TLN1(12)	38697850	76	68	73	21	10	8	7	27	24	0	0.511	1.000	1.000
444	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(3), IL22RA1(1), IL22RA2(1), JAK1(6), JAK2(7), JAK3(4), SOCS3(2), STAT1(6), STAT3(4), STAT5A(4), STAT5B(4), TYK2(7)	21777380	49	47	47	15	4	1	10	17	17	0	0.895	1.000	1.000
445	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(9), ACE2(2), AGT(4), AGTR1(2), AGTR2(1), ANPEP(11), CMA1(2), CTSA(2), ENPEP(5), LNPEP(4), MAS1(2), MME(6), REN(1), THOP1(1)	24777470	52	45	48	16	3	5	16	18	10	0	0.621	1.000	1.000
446	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	22	CHUK(2), IKBKB(3), IL1R1(3), IRAK1(3), MAP3K1(8), MAP3K7(3), NFKB1(1), NFKBIA(1), RELA(7), RIPK1(2), TLR4(2), TNF(1), TNFAIP3(2), TNFRSF1A(1), TNFRSF1B(2), TRADD(2), TRAF6(2)	28790971	45	39	42	12	4	9	3	11	17	1	0.637	1.000	1.000
447	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CCR5(1), CD3E(1), CD3G(2), ETV5(3), IFNG(2), IL12RB1(3), IL12RB2(3), IL18(1), IL18R1(1), JAK2(7), JUN(2), MAPK14(2), STAT4(2), TYK2(7)	22004144	37	36	36	11	3	1	6	17	10	0	0.816	1.000	1.000
448	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	93	AKT1(1), AKT2(4), AKT3(2), BCL10(2), CARD11(9), CBL(2), CBLB(5), CBLC(2), CD28(1), CD3E(1), CD3G(2), CD4(10), CD8A(1), CDC42(1), CDK4(7), CHUK(2), CTLA4(1), FOS(1), FYN(2), GRAP2(1), GRB2(3), HRAS(1), ICOS(3), IFNG(2), IKBKB(3), IL2(1), IL4(1), ITK(2), JUN(2), KRAS(6), LCK(1), LCP2(2), MALT1(2), MAP3K8(1), NCK1(1), NCK2(1), NFAT5(9), NFATC1(4), NFATC2(6), NFATC3(8), NFATC4(3), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIB(2), NRAS(3), PAK1(4), PAK2(4), PAK3(2), PAK4(5), PAK6(4), PAK7(3), PDK1(1), PIK3CA(16), PIK3CB(6), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(6), PLCG1(3), PPP3CA(2), PPP3CB(1), PPP3CC(3), PRKCQ(4), PTPN6(3), PTPRC(7), RASGRP1(3), SOS1(7), SOS2(7), TEC(5), TNF(1), VAV1(6), VAV2(4), VAV3(2), ZAP70(1)	119166997	254	188	229	40	21	37	32	98	65	1	0.000968	1.000	1.000
449	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(4), BAX(1), BCL2A1(2), CASP1(2), CASP10(3), CASP2(1), CASP4(3), CASP6(1), CASP7(1), CASP8(1), CASP9(2), CD40(1), DAXX(6), DFFA(1), DFFB(1), FAS(2), FASLG(2), IKBKE(3), LTA(1), MCL1(1), NFKB1(1), NFKBIA(1), NGFR(2), NR3C1(4), NTRK1(6), PTPN13(10), RIPK1(2), TFG(2), TNF(1), TNFRSF1A(1), TNFRSF1B(2), TRADD(2), TRAF2(1), TRAF3(1), TRAF6(2)	51089403	77	69	76	17	4	14	12	30	17	0	0.200	1.000	1.000
450	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(2), ALOX5(4), CYP1A2(6), CYP2C18(3), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP2E1(1), CYP2J2(4), CYP3A43(2), CYP3A5(1), CYP3A7(2), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(5), RDH11(4), RDH12(3), RDH13(1)	28365685	46	43	46	13	5	6	4	19	11	1	0.493	1.000	1.000
451	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	192	ACTB(4), ACTG1(3), ACTN1(1), ACTN2(3), ACTN4(4), AKT1(1), AKT2(4), AKT3(2), ARHGAP5(5), BCAR1(5), BIRC2(3), BIRC3(6), BRAF(6), CAPN2(3), CAV2(2), CAV3(1), CCND2(1), CCND3(1), CDC42(1), CHAD(5), COL11A1(11), COL11A2(5), COL1A1(3), COL1A2(11), COL2A1(7), COL3A1(3), COL4A1(4), COL4A2(4), COL4A4(3), COL4A6(6), COL5A1(10), COL5A2(6), COL5A3(15), COL6A1(2), COL6A2(10), COL6A3(18), COL6A6(17), CTNNB1(4), DIAPH1(7), DOCK1(2), EGF(5), EGFR(10), ELK1(2), ERBB2(8), FARP2(3), FIGF(2), FLNA(5), FLNB(7), FLNC(7), FLT1(8), FN1(8), FYN(2), GRB2(3), GSK3B(3), HGF(2), HRAS(1), IBSP(1), IGF1R(4), ILK(4), ITGA1(8), ITGA10(6), ITGA11(6), ITGA2(3), ITGA2B(2), ITGA3(6), ITGA4(3), ITGA5(7), ITGA6(7), ITGA7(6), ITGA8(2), ITGA9(3), ITGAV(2), ITGB1(6), ITGB3(4), ITGB4(7), ITGB5(6), ITGB6(2), ITGB7(4), ITGB8(3), JUN(2), KDR(6), LAMA1(11), LAMA2(7), LAMA3(13), LAMA4(8), LAMA5(7), LAMB1(14), LAMB2(7), LAMB3(2), LAMB4(7), LAMC1(7), LAMC2(6), LAMC3(9), MAPK1(1), MAPK10(2), MAPK3(3), MAPK9(2), MET(28), MYL2(1), MYL7(2), MYL9(1), MYLK(5), MYLK2(1), PAK1(4), PAK2(4), PAK3(2), PAK4(5), PAK6(4), PAK7(3), PARVA(1), PARVB(1), PARVG(2), PDGFC(1), PDGFD(3), PDGFRA(6), PDGFRB(3), PGF(2), PIK3CA(16), PIK3CB(6), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(6), PIP5K1C(3), PPP1CC(2), PPP1R12A(4), PRKCA(3), PRKCG(5), PTEN(35), PTK2(3), PXN(3), RAC2(1), RAC3(1), RAF1(5), RAP1A(1), RAPGEF1(6), RELN(8), ROCK1(7), ROCK2(3), SHC1(4), SHC2(2), SHC3(1), SHC4(1), SOS1(7), SOS2(7), SPP1(3), SRC(2), THBS1(16), THBS2(3), THBS3(5), THBS4(4), TLN1(12), TLN2(12), TNC(11), TNN(3), TNR(9), TNXB(11), VAV1(6), VAV2(4), VAV3(2), VCL(3), VEGFA(1), VEGFC(2), VTN(1), VWF(15), ZYX(1)	435046607	861	460	823	228	88	130	104	287	242	10	0.0651	1.000	1.000
452	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	248	ACVR1B(4), ACVR1C(3), AKT1(1), AKT2(4), AKT3(2), ARRB1(2), ARRB2(1), ATF2(3), ATF4(2), BDNF(2), BRAF(6), CACNA1A(14), CACNA1B(9), CACNA1C(15), CACNA1D(12), CACNA1E(7), CACNA1F(4), CACNA1G(12), CACNA1H(10), CACNA1I(4), CACNA1S(14), CACNA2D1(6), CACNA2D2(1), CACNA2D3(1), CACNA2D4(6), CACNB1(4), CACNB2(1), CACNB4(1), CACNG2(3), CACNG3(2), CACNG5(1), CACNG6(1), CACNG7(2), CACNG8(1), CDC25B(1), CDC42(1), CHUK(2), DAXX(6), DUSP10(1), DUSP16(1), DUSP3(2), DUSP4(1), DUSP5(1), DUSP6(2), DUSP7(1), DUSP8(1), DUSP9(2), ECSIT(5), EGF(5), EGFR(10), ELK1(2), ELK4(2), FAS(2), FASLG(2), FGF1(1), FGF10(1), FGF11(1), FGF12(1), FGF13(1), FGF14(1), FGF19(2), FGF20(1), FGF3(2), FGF4(1), FGF5(1), FGF6(4), FGF7(3), FGFR1(6), FGFR2(4), FGFR3(7), FGFR4(5), FLNA(5), FLNB(7), FLNC(7), FOS(1), GADD45B(2), GNA12(1), GNG12(1), GRB2(3), HRAS(1), IKBKB(3), IL1B(1), IL1R1(3), IL1R2(7), JUN(2), KRAS(6), MAP2K2(1), MAP2K3(3), MAP2K5(3), MAP2K7(3), MAP3K1(8), MAP3K10(4), MAP3K12(5), MAP3K13(2), MAP3K2(2), MAP3K3(3), MAP3K4(9), MAP3K5(5), MAP3K6(5), MAP3K7(3), MAP3K8(1), MAP4K1(3), MAP4K2(2), MAP4K3(4), MAP4K4(2), MAPK1(1), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(2), MAPK3(3), MAPK7(1), MAPK8IP1(4), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2), MAPKAPK2(2), MAPT(5), MAX(5), MEF2C(1), MKNK1(2), MKNK2(2), MOS(1), MRAS(1), MYC(1), NF1(15), NFATC2(6), NFATC4(3), NFKB1(1), NFKB2(3), NR4A1(1), NRAS(3), NTRK1(6), NTRK2(3), PAK1(4), PAK2(4), PDGFRA(6), PDGFRB(3), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(5), PPM1A(1), PPM1B(3), PPP3CA(2), PPP3CB(1), PPP3CC(3), PPP5C(3), PRKACA(1), PRKACB(2), PRKACG(3), PRKCA(3), PRKCG(5), PRKX(2), PTPN5(4), PTPN7(1), PTPRR(6), RAC2(1), RAC3(1), RAF1(5), RAP1A(1), RAPGEF2(7), RASA1(7), RASA2(1), RASGRF1(11), RASGRF2(4), RASGRP1(3), RASGRP2(2), RASGRP3(2), RASGRP4(4), RPS6KA1(7), RPS6KA3(2), RPS6KA4(2), RPS6KA5(3), RPS6KA6(1), RRAS2(8), SOS1(7), SOS2(7), STK3(1), STMN1(1), TAOK2(4), TAOK3(3), TGFB2(2), TGFBR1(1), TGFBR2(1), TNF(1), TNFRSF1A(1), TP53(50), TRAF2(1), TRAF6(2), ZAK(5)	340144446	678	396	642	160	81	91	86	230	183	7	0.00489	1.000	1.000
453	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	203	ABI2(3), ACTN1(1), ACTN2(3), ACTN4(4), APC(11), APC2(5), ARHGEF1(2), ARHGEF12(4), ARHGEF4(2), ARHGEF6(3), ARHGEF7(6), ARPC1B(1), ARPC2(8), ARPC5L(1), BAIAP2(3), BCAR1(5), BDKRB1(1), BDKRB2(1), BRAF(6), CDC42(1), CFL1(1), CFL2(1), CHRM1(2), CHRM2(5), CHRM3(3), CHRM5(2), CSK(4), CYFIP1(7), CYFIP2(6), DIAPH1(7), DIAPH2(3), DIAPH3(7), DOCK1(2), EGF(5), EGFR(10), EZR(2), F2(4), F2R(2), FGD1(2), FGD3(2), FGF1(1), FGF10(1), FGF11(1), FGF12(1), FGF13(1), FGF14(1), FGF19(2), FGF20(1), FGF3(2), FGF4(1), FGF5(1), FGF6(4), FGF7(3), FGFR1(6), FGFR2(4), FGFR3(7), FGFR4(5), FN1(8), GIT1(2), GNA12(1), GNA13(6), GNG12(1), GSN(4), HRAS(1), INS(1), IQGAP1(5), IQGAP2(6), IQGAP3(7), ITGA1(8), ITGA10(6), ITGA11(6), ITGA2(3), ITGA2B(2), ITGA3(6), ITGA4(3), ITGA5(7), ITGA6(7), ITGA7(6), ITGA8(2), ITGA9(3), ITGAD(12), ITGAE(7), ITGAL(6), ITGAM(9), ITGAV(2), ITGAX(10), ITGB1(6), ITGB2(2), ITGB3(4), ITGB4(7), ITGB5(6), ITGB6(2), ITGB7(4), ITGB8(3), KRAS(6), LIMK1(6), LIMK2(3), MAP2K2(1), MAPK1(1), MAPK3(3), MOS(1), MRAS(1), MSN(3), MYH10(6), MYH14(10), MYH9(5), MYL2(1), MYL7(2), MYL9(1), MYLK(5), MYLK2(1), NCKAP1(2), NCKAP1L(6), NRAS(3), PAK1(4), PAK2(4), PAK3(2), PAK4(5), PAK6(4), PAK7(3), PDGFRA(6), PDGFRB(3), PFN1(1), PFN3(1), PFN4(1), PIK3CA(16), PIK3CB(6), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(6), PIP4K2A(3), PIP4K2B(2), PIP4K2C(3), PIP5K1A(2), PIP5K1C(3), PPP1CC(2), PPP1R12A(4), PPP1R12B(3), PTK2(3), PXN(3), RAC2(1), RAC3(1), RAF1(5), RDX(2), ROCK1(7), ROCK2(3), RRAS2(8), SCIN(4), SLC9A1(3), SOS1(7), SOS2(7), SSH1(4), SSH2(13), SSH3(2), TIAM1(9), TIAM2(2), VAV1(6), VAV2(4), VAV3(2), VCL(3), WAS(1), WASF1(1), WASF2(2), WASL(9)	327913212	649	396	608	155	61	79	88	240	177	4	0.0276	1.000	1.000
454	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	168	ADCY1(2), ADCY2(6), ADCY3(5), ADCY4(4), ADCY7(2), ADCY8(12), ADCY9(8), ADORA2A(5), ADORA2B(1), ADRA1A(4), ADRB2(2), AGTR1(2), ATP2A1(7), ATP2A2(7), ATP2A3(5), ATP2B1(3), ATP2B2(1), ATP2B3(4), ATP2B4(4), AVPR1A(1), BDKRB1(1), BDKRB2(1), CACNA1A(14), CACNA1B(9), CACNA1C(15), CACNA1D(12), CACNA1E(7), CACNA1F(4), CACNA1G(12), CACNA1H(10), CACNA1I(4), CACNA1S(14), CALM2(1), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CAMK4(3), CCKAR(4), CCKBR(3), CD38(1), CHRM1(2), CHRM2(5), CHRM3(3), CHRM5(2), CHRNA7(2), CYSLTR1(1), DRD1(1), EDNRB(3), EGFR(10), ERBB2(8), ERBB3(7), ERBB4(11), F2R(2), GNA14(1), GNA15(1), GNAS(5), GRIN1(2), GRIN2A(10), GRIN2D(3), GRM1(5), GRM5(8), GRPR(2), HRH2(1), HTR2A(1), HTR2B(2), HTR2C(1), HTR4(2), HTR6(1), HTR7(2), ITPKA(1), ITPKB(3), ITPR1(11), ITPR2(14), ITPR3(7), LHCGR(1), LTB4R2(2), MYLK(5), MYLK2(1), NOS1(10), NOS3(3), NTSR1(2), OXTR(1), P2RX1(3), P2RX2(4), P2RX3(3), P2RX7(2), PDE1A(1), PDE1B(6), PDE1C(3), PDGFRA(6), PDGFRB(3), PHKA1(10), PHKA2(5), PHKB(4), PHKG1(3), PHKG2(1), PLCB1(3), PLCB2(5), PLCB3(4), PLCB4(5), PLCD1(3), PLCD3(1), PLCD4(3), PLCE1(5), PLCG1(3), PLCG2(3), PLCZ1(4), PPID(2), PPP3CA(2), PPP3CB(1), PPP3CC(3), PRKACA(1), PRKACB(2), PRKACG(3), PRKCA(3), PRKCG(5), PRKX(2), PTAFR(1), PTGER3(7), PTGFR(5), PTK2B(4), RYR1(23), RYR2(16), RYR3(19), SLC25A4(2), SLC25A5(3), SLC25A6(2), SLC8A1(4), SLC8A2(3), SLC8A3(4), SPHK1(1), SPHK2(2), TACR1(1), TACR2(1), TACR3(2), TBXA2R(4), TRHR(2), TRPC1(4), VDAC2(1), VDAC3(3)	319810401	604	386	584	175	94	84	66	209	151	0	0.158	1.000	1.000
455	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	136	ACTB(4), ACTG1(3), CHAD(5), COL11A1(11), COL11A2(5), COL17A1(5), COL1A1(3), COL1A2(11), COL2A1(7), COL3A1(3), COL4A1(4), COL4A2(4), COL4A4(3), COL4A6(6), COL5A1(10), COL5A2(6), COL5A3(15), COL6A1(2), COL6A2(10), COL6A3(18), COL6A6(17), DES(1), DSC2(4), DSC3(2), DSG1(5), DSG2(3), DSG3(3), DSG4(4), FN1(8), GJA10(3), GJA3(2), GJA4(1), GJA5(5), GJA8(1), GJA9(1), GJB1(2), GJB3(4), GJB6(2), GJB7(1), GJC1(3), GJC2(1), GJC3(1), GJD2(1), IBSP(1), ITGA6(7), ITGB4(7), KRT1(2), KRT10(4), KRT12(2), KRT13(6), KRT15(3), KRT16(1), KRT17(4), KRT19(3), KRT2(9), KRT20(1), KRT23(4), KRT24(2), KRT25(2), KRT27(5), KRT28(2), KRT3(7), KRT31(1), KRT32(1), KRT33A(1), KRT33B(3), KRT34(1), KRT36(2), KRT37(1), KRT38(2), KRT39(1), KRT4(5), KRT40(1), KRT5(4), KRT6A(3), KRT6B(2), KRT6C(1), KRT7(1), KRT71(2), KRT72(4), KRT73(3), KRT74(2), KRT75(3), KRT76(4), KRT77(2), KRT78(3), KRT79(4), KRT81(1), KRT82(3), KRT83(2), KRT84(4), KRT85(6), KRT86(3), KRT9(2), LAMA1(11), LAMA2(7), LAMA3(13), LAMA4(8), LAMA5(7), LAMB1(14), LAMB2(7), LAMB3(2), LAMB4(7), LAMC1(7), LAMC2(6), LAMC3(9), LMNA(2), LMNB1(4), LMNB2(2), NES(6), PRPH(2), RELN(8), SPP1(3), THBS1(16), THBS2(3), THBS3(5), THBS4(4), TNC(11), TNN(3), TNR(9), TNXB(11), VIM(2), VTN(1), VWF(15)	289055100	565	361	548	193	69	87	61	179	166	3	0.913	1.000	1.000
456	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(11), CD44(3), CHAD(5), COL11A1(11), COL11A2(5), COL1A1(3), COL1A2(11), COL2A1(7), COL3A1(3), COL4A1(4), COL4A2(4), COL4A4(3), COL4A6(6), COL5A1(10), COL5A2(6), COL5A3(15), COL6A1(2), COL6A2(10), COL6A3(18), COL6A6(17), DAG1(3), FN1(8), FNDC1(2), FNDC3A(3), FNDC5(1), HMMR(1), HSPG2(16), IBSP(1), ITGA1(8), ITGA10(6), ITGA11(6), ITGA2(3), ITGA2B(2), ITGA3(6), ITGA4(3), ITGA5(7), ITGA6(7), ITGA7(6), ITGA8(2), ITGA9(3), ITGAV(2), ITGB1(6), ITGB3(4), ITGB4(7), ITGB5(6), ITGB6(2), ITGB7(4), ITGB8(3), LAMA1(11), LAMA2(7), LAMA3(13), LAMA4(8), LAMA5(7), LAMB1(14), LAMB2(7), LAMB3(2), LAMB4(7), LAMC1(7), LAMC2(6), LAMC3(9), RELN(8), SDC1(1), SDC3(1), SDC4(2), SPP1(3), SV2A(2), SV2B(3), SV2C(3), THBS1(16), THBS2(3), THBS3(5), THBS4(4), TNC(11), TNN(3), TNR(9), TNXB(11), VTN(1), VWF(15)	261428285	481	327	468	143	50	73	54	156	144	4	0.504	1.000	1.000
457	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	236	ADCYAP1R1(2), ADORA2A(5), ADORA2B(1), ADORA3(2), ADRA1A(4), ADRA2A(1), ADRA2B(1), ADRB2(2), AGTR1(2), AGTR2(1), AVPR1A(1), AVPR2(2), BDKRB1(1), BDKRB2(1), BRS3(2), C3AR1(4), C5AR1(2), CALCR(5), CALCRL(3), CCKAR(4), CCKBR(3), CGA(1), CHRM1(2), CHRM2(5), CHRM3(3), CHRM5(2), CNR1(1), CNR2(3), CRHR1(2), CRHR2(4), CYSLTR1(1), DRD1(1), DRD2(2), DRD3(3), DRD5(3), EDNRB(3), F2(4), F2R(2), F2RL1(1), F2RL2(2), F2RL3(1), FPR1(2), FSHR(2), GABBR1(6), GABRA1(3), GABRA2(1), GABRA3(2), GABRA4(1), GABRA5(1), GABRA6(1), GABRB1(2), GABRB2(4), GABRB3(3), GABRD(2), GABRE(4), GABRG1(3), GABRG2(7), GABRG3(3), GABRP(1), GABRQ(9), GABRR1(2), GALR1(1), GH2(1), GHR(1), GIPR(2), GLP1R(3), GLP2R(5), GLRA1(5), GLRA2(1), GLRB(2), GPR156(1), GPR35(3), GPR50(3), GPR63(1), GPR83(2), GRIA1(9), GRIA2(5), GRIA3(2), GRIA4(4), GRID1(4), GRID2(8), GRIK1(2), GRIK2(4), GRIK3(5), GRIK4(1), GRIK5(5), GRIN1(2), GRIN2A(10), GRIN2B(8), GRIN2D(3), GRIN3A(3), GRIN3B(3), GRM1(5), GRM2(3), GRM3(7), GRM4(5), GRM5(8), GRM6(3), GRM7(5), GRM8(3), GRPR(2), HCRTR1(3), HCRTR2(4), HRH2(1), HRH3(1), HRH4(1), HTR1A(3), HTR1B(1), HTR1D(2), HTR1E(3), HTR1F(2), HTR2A(1), HTR2B(2), HTR2C(1), HTR4(2), HTR6(1), HTR7(2), LEP(1), LEPR(5), LHCGR(1), LTB4R2(2), MAS1(2), MC1R(2), MC2R(2), MC3R(2), MC4R(1), MC5R(1), MCHR1(1), MCHR2(2), MLNR(1), MTNR1B(1), NMUR2(4), NPBWR1(1), NPBWR2(2), NPFFR2(2), NPY1R(2), NPY2R(3), NR3C1(4), NTSR1(2), OPRD1(3), OPRK1(2), OPRL1(1), OPRM1(4), OXTR(1), P2RX1(3), P2RX2(4), P2RX3(3), P2RX7(2), P2RY1(3), P2RY10(1), P2RY11(1), P2RY13(1), P2RY14(1), P2RY2(2), P2RY4(2), P2RY8(3), PARD3(7), PRLR(3), PRSS1(6), PRSS3(11), PTAFR(1), PTGDR(1), PTGER2(1), PTGER3(7), PTGER4(1), PTGFR(5), PTGIR(1), RXFP1(3), RXFP2(1), SCTR(1), SSTR1(3), SSTR2(2), SSTR3(1), SSTR4(1), TAAR2(2), TACR1(1), TACR2(1), TACR3(2), TBXA2R(4), THRA(2), TRHR(2), TRPV1(3), TSHR(3), TSPO(1), VIPR1(1), VIPR2(1)	255226311	494	321	478	145	68	68	68	180	109	1	0.162	1.000	1.000
458	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	131	ACTB(4), ACTG1(3), ACTN1(1), ACTN2(3), ACTN4(4), AKT1(1), AKT2(4), AKT3(2), AMOTL1(3), ASH1L(8), CASK(1), CDC42(1), CDK4(7), CGN(3), CLDN10(2), CLDN11(2), CLDN15(1), CLDN16(2), CLDN18(2), CLDN2(1), CLDN23(1), CLDN3(1), CLDN4(2), CLDN6(1), CLDN7(1), CRB3(1), CSNK2A1(3), CSNK2A2(2), CSNK2B(1), CTNNA1(9), CTNNA2(7), CTNNA3(3), CTNNB1(4), EPB41(2), EPB41L1(4), EPB41L2(2), EPB41L3(8), EXOC4(4), F11R(1), GNAI1(3), GNAI2(3), HCLS1(1), HRAS(1), IGSF5(5), INADL(8), JAM3(3), KRAS(6), LLGL1(6), LLGL2(2), MAGI1(5), MAGI2(4), MAGI3(5), MLLT4(12), MPDZ(4), MPP5(1), MRAS(1), MYH1(7), MYH10(6), MYH11(9), MYH13(7), MYH14(10), MYH15(6), MYH2(9), MYH3(7), MYH4(16), MYH6(8), MYH7(15), MYH7B(7), MYH8(8), MYH9(5), MYL2(1), MYL7(2), MYL9(1), NRAS(3), OCLN(3), PARD3(7), PARD6B(11), PPM1J(3), PPP2CA(1), PPP2CB(1), PPP2R1A(3), PPP2R1B(2), PPP2R2A(6), PPP2R2B(3), PPP2R2C(2), PPP2R3A(2), PPP2R3B(1), PPP2R4(1), PRKCA(3), PRKCD(5), PRKCE(4), PRKCG(5), PRKCH(4), PRKCI(5), PRKCQ(4), PRKCZ(1), PTEN(35), RRAS2(8), SPTAN1(11), SRC(2), SYMPK(3), TJAP1(3), TJP1(5), TJP2(5), TJP3(2), YES1(2), ZAK(5)	228342188	467	310	440	133	39	51	62	144	165	6	0.728	1.000	1.000
459	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(2), ADCY2(6), ADCY3(5), ADCY4(4), ADCY5(6), ADCY6(3), ADCY7(2), ADCY8(12), ADCY9(8), ADRA1A(4), ADRB2(2), ANXA6(2), ARRB1(2), ARRB2(1), ATP1A4(5), ATP1B1(7), ATP2A2(7), ATP2A3(5), ATP2B1(3), ATP2B2(1), ATP2B3(4), CACNA1A(14), CACNA1B(9), CACNA1C(15), CACNA1D(12), CACNA1E(7), CACNA1S(14), CACNB1(4), CALM2(1), CALR(2), CAMK1(3), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CAMK4(3), CASQ1(4), CASQ2(2), CHRM1(2), CHRM2(5), CHRM3(3), CHRM5(2), GJA4(1), GJA5(5), GJB1(2), GJB3(4), GJB6(2), GNAI2(3), GNAO1(1), GNAZ(4), GNB1(3), GNB3(2), GNB5(3), GNG12(1), GNG13(1), GNG3(1), GNG7(1), GRK4(1), GRK5(2), GRK6(5), ITPR1(11), ITPR2(14), ITPR3(7), KCNB1(4), KCNJ3(4), MIB1(1), MYCBP(1), NME7(2), PKIA(1), PLCB3(4), PRKACA(1), PRKACB(2), PRKAR1A(3), PRKAR2B(4), PRKCA(3), PRKCD(5), PRKCE(4), PRKCG(5), PRKCH(4), PRKCQ(4), PRKCZ(1), PRKD1(3), RGS1(1), RGS11(1), RGS14(2), RGS16(1), RGS17(2), RGS18(2), RGS2(2), RGS20(1), RGS3(6), RGS6(3), RGS7(2), RGS9(4), RYR1(23), RYR2(16), RYR3(19), SFN(1), SLC8A1(4), SLC8A3(4), USP5(4), YWHAB(1)	223652632	430	302	419	137	73	49	44	147	117	0	0.590	1.000	1.000
460	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	127	ABL1(6), ABLIM1(5), ABLIM2(1), ABLIM3(3), ARHGEF12(4), CDC42(1), CFL1(1), CFL2(1), CXCR4(1), DCC(8), DPYSL2(3), EFNA1(3), EFNA2(1), EFNA3(1), EFNA5(1), EFNB1(1), EFNB3(12), EPHA1(4), EPHA2(1), EPHA3(8), EPHA4(3), EPHA5(8), EPHA6(4), EPHA7(2), EPHA8(3), EPHB1(3), EPHB2(3), EPHB3(1), EPHB4(6), EPHB6(7), FES(4), FYN(2), GNAI1(3), GNAI2(3), GSK3B(3), HRAS(1), ITGB1(6), KRAS(6), L1CAM(5), LIMK1(6), LIMK2(3), LRRC4C(2), MAPK1(1), MAPK3(3), MET(28), NCK1(1), NCK2(1), NFAT5(9), NFATC1(4), NFATC2(6), NFATC3(8), NFATC4(3), NGEF(2), NRAS(3), NRP1(2), NTN1(1), NTN4(2), NTNG1(2), PAK1(4), PAK2(4), PAK3(2), PAK4(5), PAK6(4), PAK7(3), PLXNA1(3), PLXNA2(9), PLXNA3(5), PLXNB1(8), PLXNB2(7), PLXNB3(3), PLXNC1(5), PPP3CA(2), PPP3CB(1), PPP3CC(3), PTK2(3), RAC2(1), RAC3(1), RASA1(7), RGS3(6), RND1(2), ROBO1(5), ROBO2(9), ROBO3(3), ROCK1(7), ROCK2(3), SEMA3A(3), SEMA3C(2), SEMA3D(3), SEMA3E(4), SEMA3F(4), SEMA3G(1), SEMA4A(2), SEMA4B(1), SEMA4C(2), SEMA4D(2), SEMA4F(8), SEMA4G(4), SEMA5A(6), SEMA5B(1), SEMA6A(5), SEMA6B(1), SEMA6C(4), SEMA6D(3), SEMA7A(1), SLIT1(3), SLIT2(10), SLIT3(7), SRGAP1(9), SRGAP2(1), SRGAP3(4), UNC5A(4), UNC5B(5), UNC5C(4), UNC5D(2)	228798870	447	298	404	129	38	53	54	158	142	2	0.763	1.000	1.000
461	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	251	ACVR1(1), ACVR1B(4), ACVR2A(5), ACVR2B(1), AMHR2(9), BMP2(1), BMP7(5), BMPR1A(2), BMPR1B(1), BMPR2(6), CCL2(1), CCL27(3), CCL3(1), CCR2(2), CCR3(1), CCR5(1), CCR6(1), CCR7(1), CCR9(3), CD27(2), CD40(1), CLCF1(1), CNTF(2), CSF1R(8), CSF2RA(3), CSF2RB(7), CSF3R(3), CX3CL1(2), CX3CR1(1), CXCL11(1), CXCL13(1), CXCL5(1), CXCL9(1), CXCR4(1), CXCR6(3), EDA(1), EDA2R(1), EGF(5), EGFR(10), EPOR(1), FAS(2), FASLG(2), FLT1(8), FLT3(7), FLT4(15), GDF5(3), GH2(1), GHR(1), HGF(2), IFNA1(1), IFNA14(1), IFNA16(1), IFNA2(2), IFNA21(3), IFNA5(1), IFNA7(3), IFNA8(2), IFNAR1(3), IFNB1(2), IFNG(2), IFNGR1(3), IFNGR2(2), IFNK(2), IL10RA(3), IL10RB(1), IL11RA(2), IL12RB1(3), IL12RB2(3), IL13RA1(2), IL15(1), IL15RA(2), IL17RA(2), IL17RB(3), IL18(1), IL18R1(1), IL18RAP(4), IL19(2), IL1B(1), IL1R1(3), IL1R2(7), IL1RAP(4), IL2(1), IL20RA(1), IL21(1), IL21R(6), IL22RA1(1), IL22RA2(1), IL23A(1), IL23R(4), IL25(2), IL26(1), IL2RA(2), IL2RB(2), IL3(1), IL4(1), IL4R(5), IL5RA(1), IL6R(2), IL6ST(5), IL7R(1), IL9(1), IL9R(4), INHBA(2), INHBB(2), INHBC(1), INHBE(2), KDR(6), KITLG(2), LEP(1), LEPR(5), LIF(1), LIFR(4), LTA(1), LTB(1), LTBR(3), MET(28), NGFR(2), OSM(1), OSMR(1), PDGFC(1), PDGFRA(6), PDGFRB(3), PF4(1), PLEKHO2(2), PRLR(3), RELT(1), TGFB2(2), TGFBR1(1), TGFBR2(1), TNF(1), TNFRSF10B(1), TNFRSF10C(2), TNFRSF10D(1), TNFRSF11A(2), TNFRSF11B(1), TNFRSF13B(1), TNFRSF14(1), TNFRSF19(1), TNFRSF1A(1), TNFRSF1B(2), TNFRSF21(2), TNFRSF4(1), TNFRSF8(1), TNFRSF9(1), TNFSF10(9), TNFSF13(1), TNFSF14(1), TNFSF15(2), TNFSF8(2), TNFSF9(1), TPO(4), VEGFA(1), VEGFC(2), XCL1(2), XCR1(1)	207849188	392	283	369	75	38	55	51	152	96	0	0.000738	1.000	1.000
462	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	144	APC(11), APC2(5), AXIN1(5), AXIN2(3), BTRC(4), CACYBP(4), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CCND2(1), CCND3(1), CER1(1), CHD8(8), CREBBP(13), CSNK1A1(2), CSNK1E(3), CSNK2A1(3), CSNK2A2(2), CSNK2B(1), CTBP1(2), CTBP2(1), CTNNB1(4), CUL1(5), CXXC4(2), DAAM1(5), DAAM2(3), DVL1(1), DVL2(1), DVL3(1), EP300(16), FBXW11(1), FZD1(2), FZD10(3), FZD2(3), FZD3(1), FZD4(4), FZD5(3), FZD7(3), FZD8(2), GSK3B(3), JUN(2), LEF1(3), LRP5(6), LRP6(10), MAP3K7(3), MAPK10(2), MAPK9(2), MYC(1), NFAT5(9), NFATC1(4), NFATC2(6), NFATC3(8), NFATC4(3), NKD1(4), NKD2(3), PLCB1(3), PLCB2(5), PLCB3(4), PLCB4(5), PORCN(2), PPARD(1), PPP2CA(1), PPP2CB(1), PPP2R1A(3), PPP2R1B(2), PPP2R2A(6), PPP2R2B(3), PPP2R2C(2), PPP3CA(2), PPP3CB(1), PPP3CC(3), PRICKLE1(5), PRICKLE2(2), PRKACA(1), PRKACB(2), PRKACG(3), PRKCA(3), PRKCG(5), PRKX(2), PSEN1(1), RAC2(1), RAC3(1), RBX1(1), ROCK1(7), ROCK2(3), RUVBL1(1), SENP2(2), SFRP2(1), SFRP4(2), SFRP5(1), SMAD2(3), SMAD3(2), SMAD4(4), SOX17(1), TBL1X(4), TBL1XR1(4), TCF7L1(3), TCF7L2(1), TP53(50), VANGL1(3), VANGL2(3), WIF1(5), WNT1(2), WNT10A(3), WNT11(1), WNT2(3), WNT2B(3), WNT3(2), WNT3A(1), WNT5B(2), WNT7A(1), WNT7B(2), WNT8A(2), WNT8B(1), WNT9B(3)	186982200	404	283	385	94	41	45	57	135	122	4	0.0343	1.000	1.000
463	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	130	ACACA(8), ACACB(5), AKT1(1), AKT2(4), AKT3(2), BRAF(6), CALM2(1), CBL(2), CBLB(5), CBLC(2), ELK1(2), EXOC7(8), FASN(8), FLOT1(1), FLOT2(1), FOXO1(3), G6PC(3), GCK(1), GRB2(3), GSK3B(3), GYS1(3), GYS2(2), HRAS(1), IKBKB(3), INPP5D(2), INS(1), INSR(4), IRS1(6), IRS4(1), KRAS(6), LIPE(5), MAP2K2(1), MAPK1(1), MAPK10(2), MAPK3(3), MAPK9(2), MKNK1(2), MKNK2(2), NRAS(3), PCK1(9), PCK2(2), PDE3A(5), PDE3B(3), PFKL(3), PFKM(3), PFKP(3), PHKA1(10), PHKA2(5), PHKB(4), PHKG1(3), PHKG2(1), PIK3CA(16), PIK3CB(6), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(6), PKLR(1), PPARGC1A(3), PPP1CC(2), PPP1R3A(4), PPP1R3B(1), PPP1R3C(1), PPP1R3D(1), PRKAA1(2), PRKAA2(4), PRKAB1(1), PRKACA(1), PRKACB(2), PRKACG(3), PRKAG1(6), PRKAG2(7), PRKAG3(1), PRKAR1A(3), PRKAR2B(4), PRKCI(5), PRKCZ(1), PRKX(2), PTPN1(2), PTPRF(6), PYGB(3), PYGL(1), PYGM(4), RAF1(5), RAPGEF1(6), RHEB(4), RHOQ(2), RPS6KB1(2), RPS6KB2(3), SH2B2(1), SHC1(4), SHC2(2), SHC3(1), SHC4(1), SLC2A4(3), SOCS1(1), SOCS3(2), SOCS4(1), SORBS1(2), SOS1(7), SOS2(7), SREBF1(4), TRIP10(2), TSC1(5), TSC2(14)	186862346	363	268	338	74	37	57	50	133	82	4	0.00102	1.000	1.000
464	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ACTA1(1), ACTA2(1), ADCY1(2), ADCY2(6), ADCY3(5), ADCY4(4), ADCY5(6), ADCY6(3), ADCY7(2), ADCY8(12), ADCY9(8), ARRB1(2), ARRB2(1), ATF1(2), ATF2(3), ATF4(2), ATF5(1), ATP2A2(7), ATP2A3(5), CALCA(1), CALM2(1), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CNN2(3), CORIN(2), CRH(1), CRHR1(2), DGKZ(3), ETS2(1), FOS(1), GABPA(1), GABPB2(2), GBA2(6), GNB1(3), GNB3(2), GNB5(3), GNG12(1), GNG13(1), GNG3(1), GNG7(1), GRK4(1), GRK5(2), GRK6(5), GSTO1(1), GUCA2A(2), GUCA2B(1), GUCY1A3(3), IGFBP1(1), IGFBP2(3), IGFBP3(1), IGFBP4(1), IGFBP6(2), IL1B(1), ITPR1(11), ITPR2(14), ITPR3(7), JUN(2), MIB1(1), MYL2(1), MYL4(1), MYLK2(1), NFKB1(1), NOS1(10), NOS3(3), OXT(1), OXTR(1), PDE4B(1), PDE4D(1), PKIA(1), PLCB3(4), PLCD1(3), PLCG1(3), PLCG2(3), PRKACA(1), PRKACB(2), PRKAR1A(3), PRKAR2B(4), PRKCA(3), PRKCD(5), PRKCE(4), PRKCH(4), PRKCQ(4), PRKCZ(1), PRKD1(3), RAMP1(1), RAMP2(1), RAMP3(1), RGS1(1), RGS11(1), RGS14(2), RGS16(1), RGS17(2), RGS18(2), RGS2(2), RGS20(1), RGS3(6), RGS6(3), RGS7(2), RGS9(4), RLN1(1), RYR1(23), RYR2(16), RYR3(19), SFN(1), SLC8A1(4), SP1(2), TNXB(11), USP5(4), YWHAB(1)	203596345	357	261	350	106	53	51	37	121	95	0	0.524	1.000	1.000
465	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	130	ALCAM(3), CADM1(2), CADM3(2), CD2(2), CD22(4), CD226(1), CD276(2), CD28(1), CD34(2), CD4(10), CD40(1), CD58(1), CD6(4), CD80(1), CD86(3), CD8A(1), CD99(1), CDH1(3), CDH2(7), CDH3(4), CDH4(5), CDH5(4), CLDN10(2), CLDN11(2), CLDN15(1), CLDN16(2), CLDN18(2), CLDN2(1), CLDN23(1), CLDN3(1), CLDN4(2), CLDN6(1), CLDN7(1), CNTN1(8), CNTN2(4), CNTNAP1(7), CNTNAP2(5), CTLA4(1), ESAM(1), F11R(1), GLG1(7), HLA-A(6), HLA-B(9), HLA-C(13), HLA-DOB(1), HLA-DPA1(1), HLA-DPB1(3), HLA-DQA1(3), HLA-DQA2(3), HLA-DQB1(3), HLA-DRA(1), HLA-DRB1(6), HLA-DRB5(8), HLA-E(2), HLA-F(1), ICAM1(3), ICOS(3), ICOSLG(1), ITGA4(3), ITGA6(7), ITGA8(2), ITGA9(3), ITGAL(6), ITGAM(9), ITGAV(2), ITGB1(6), ITGB2(2), ITGB7(4), ITGB8(3), JAM3(3), L1CAM(5), MADCAM1(3), MAG(4), MPZL1(2), NCAM1(2), NCAM2(5), NEGR1(2), NEO1(6), NFASC(8), NLGN1(1), NLGN2(1), NRCAM(3), NRXN1(10), NRXN2(4), NRXN3(4), OCLN(3), PTPRC(7), PTPRF(6), PTPRM(10), PVRL2(5), PVRL3(4), SDC1(1), SDC3(1), SDC4(2), SELE(5), SELL(2), SELP(2), SELPLG(3), SIGLEC1(4), SPN(1), VCAM1(5), VCAN(11)	170313611	363	250	351	112	29	48	46	144	95	1	0.712	1.000	1.000
466	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	152	AKT1(1), AKT2(4), AKT3(2), CBL(2), CBLB(5), CBLC(2), CCND2(1), CCND3(1), CISH(2), CLCF1(1), CNTF(2), CREBBP(13), CSF2RA(3), CSF2RB(7), CSF3R(3), EP300(16), EPOR(1), GH2(1), GHR(1), GRB2(3), IFNA1(1), IFNA14(1), IFNA16(1), IFNA2(2), IFNA21(3), IFNA5(1), IFNA7(3), IFNA8(2), IFNAR1(3), IFNB1(2), IFNG(2), IFNGR1(3), IFNGR2(2), IFNK(2), IL10RA(3), IL10RB(1), IL11RA(2), IL12RB1(3), IL12RB2(3), IL13RA1(2), IL15(1), IL15RA(2), IL19(2), IL2(1), IL20RA(1), IL21(1), IL21R(6), IL22RA1(1), IL22RA2(1), IL23A(1), IL23R(4), IL26(1), IL2RA(2), IL2RB(2), IL3(1), IL4(1), IL4R(5), IL5RA(1), IL6R(2), IL6ST(5), IL7R(1), IL9(1), IL9R(4), IRF9(3), JAK1(6), JAK2(7), JAK3(4), LEP(1), LEPR(5), LIF(1), LIFR(4), MYC(1), OSM(1), OSMR(1), PIAS1(5), PIAS2(4), PIAS3(3), PIAS4(1), PIK3CA(16), PIK3CB(6), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(6), PRLR(3), PTPN11(1), PTPN6(3), SOCS1(1), SOCS3(2), SOCS4(1), SOCS5(2), SOCS7(2), SOS1(7), SOS2(7), SPRED1(6), SPRED2(2), SPRY1(2), SPRY2(3), SPRY4(10), STAM(6), STAT1(6), STAT2(7), STAT3(4), STAT4(2), STAT5A(4), STAT5B(4), STAT6(4), TPO(4), TYK2(7)	170784633	350	249	329	81	28	49	60	115	98	0	0.0601	1.000	1.000
467	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADA(1), ADCY1(2), ADCY2(6), ADCY3(5), ADCY4(4), ADCY5(6), ADCY6(3), ADCY7(2), ADCY8(12), ADCY9(8), ADK(2), ADSL(2), ADSSL1(3), AK2(3), AK5(2), AK7(3), ALLC(3), AMPD1(2), AMPD2(4), AMPD3(4), ATIC(3), CANT1(1), DCK(1), ENPP1(2), ENPP3(2), ENTPD2(1), ENTPD4(2), ENTPD5(3), ENTPD6(2), ENTPD8(1), GART(4), GDA(4), GMPR(3), GMPS(1), GUCY1A2(2), GUCY1A3(3), GUCY1B3(3), GUCY2C(5), GUCY2D(3), GUCY2F(6), HPRT1(1), IMPDH1(1), NME7(2), NPR1(5), NPR2(7), NT5C(1), NT5C1A(3), NT5C1B(2), NT5C2(1), NT5M(3), NUDT2(1), NUDT5(4), NUDT9(1), PAPSS1(3), PAPSS2(4), PDE10A(1), PDE11A(6), PDE1A(1), PDE1C(3), PDE2A(1), PDE3B(3), PDE4A(3), PDE4B(1), PDE4C(7), PDE4D(1), PDE5A(1), PDE7A(1), PDE7B(1), PDE8A(2), PDE8B(3), PDE9A(10), PFAS(4), PKLR(1), PNPT1(4), POLA1(3), POLD1(8), POLD2(1), POLD3(1), POLE(6), POLE2(1), POLR1A(10), POLR1B(4), POLR1C(2), POLR1D(1), POLR2A(11), POLR2B(6), POLR2C(1), POLR2D(1), POLR2F(4), POLR2I(1), POLR2K(1), POLR3A(7), POLR3B(3), POLR3G(2), POLR3GL(1), POLR3H(2), POLR3K(1), PPAT(3), PRIM1(2), PRIM2(2), PRPS1(1), PRPS1L1(2), PRPS2(4), PRUNE(3), RFC5(2), RRM1(4), RRM2(1), XDH(7)	193492226	331	237	318	74	33	48	36	116	98	0	0.0709	1.000	1.000
468	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	75	ACP1(1), ACTB(4), ACTG1(3), ACTN1(1), ACTN2(3), ACTN4(4), ACVR1B(4), ACVR1C(3), BAIAP2(3), CDC42(1), CDH1(3), CREBBP(13), CSNK2A1(3), CSNK2A2(2), CSNK2B(1), CTNNA1(9), CTNNA2(7), CTNNA3(3), CTNNB1(4), CTNND1(5), EGFR(10), EP300(16), ERBB2(8), FARP2(3), FER(2), FGFR1(6), FYN(2), IGF1R(4), INSR(4), IQGAP1(5), LEF1(3), LMO7(15), MAP3K7(3), MAPK1(1), MAPK3(3), MET(28), MLLT4(12), PARD3(7), PTPN1(2), PTPN6(3), PTPRB(7), PTPRF(6), PTPRJ(11), PTPRM(10), PVRL2(5), PVRL3(4), RAC2(1), RAC3(1), SMAD2(3), SMAD3(2), SMAD4(4), SNAI1(1), SNAI2(4), SORBS1(2), SRC(2), SSX2IP(3), TCF7L1(3), TCF7L2(1), TGFBR1(1), TGFBR2(1), TJP1(5), VCL(3), WAS(1), WASF1(1), WASF2(2), WASF3(2), WASL(9), YES1(2)	141360553	311	231	283	77	29	37	59	104	81	1	0.1000	1.000	1.000
469	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	109	ABL1(6), ANAPC1(4), ANAPC10(1), ANAPC2(2), ANAPC4(5), ANAPC5(4), ANAPC7(3), ATM(23), ATR(11), BUB1(1), BUB1B(2), BUB3(1), CCNA1(7), CCNA2(1), CCNB2(6), CCNB3(4), CCND2(1), CCND3(1), CCNE1(1), CCNE2(4), CCNH(1), CDC14A(6), CDC16(4), CDC20(3), CDC23(3), CDC25A(2), CDC25B(1), CDC25C(4), CDC27(10), CDC6(3), CDC7(1), CDK2(2), CDK4(7), CDK6(1), CDKN1A(3), CDKN1B(1), CDKN2A(4), CDKN2C(1), CHEK1(1), CHEK2(3), CREBBP(13), CUL1(5), DBF4(2), E2F1(1), E2F2(1), E2F3(1), EP300(16), ESPL1(11), FZR1(4), GADD45B(2), GSK3B(3), HDAC1(2), MAD1L1(1), MAD2L1(1), MCM2(9), MCM3(2), MCM4(1), MCM5(3), MCM6(6), MCM7(5), PCNA(3), PKMYT1(1), PLK1(1), PRKDC(10), RB1(4), RBL2(3), RBX1(1), SFN(1), SKP2(2), SMAD2(3), SMAD3(2), SMAD4(4), SMC1A(3), SMC1B(4), TGFB2(2), TP53(50), WEE1(2), YWHAB(1)	161530278	335	227	311	73	24	42	48	104	109	8	0.0113	1.000	1.000
470	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(1), AKT3(2), BCAR1(5), CAPN1(2), CAPN10(2), CAPN11(6), CAPN2(3), CAPN3(8), CAPN6(2), CAPN7(4), CAPN9(2), CAV2(2), CAV3(1), CDC42(1), CSK(4), DOCK1(2), FYN(2), GIT2(4), GRB2(3), ILK(4), ITGA10(6), ITGA11(6), ITGA2(3), ITGA2B(2), ITGA3(6), ITGA4(3), ITGA5(7), ITGA6(7), ITGA7(6), ITGA8(2), ITGA9(3), ITGAD(12), ITGAE(7), ITGAL(6), ITGAM(9), ITGAV(2), ITGAX(10), ITGB1(6), ITGB2(2), ITGB3(4), ITGB4(7), ITGB5(6), ITGB6(2), ITGB7(4), ITGB8(3), MAP2K2(1), MAP2K3(3), MAPK10(2), MAPK12(1), MAPK4(2), MAPK6(2), MAPK7(1), MYLK2(1), PAK1(4), PAK2(4), PAK3(2), PAK4(5), PAK6(4), PIK3R2(3), PTK2(3), PXN(3), RAC2(1), RAC3(1), RAPGEF1(6), RHO(1), ROCK1(7), ROCK2(3), SDCCAG8(1), SEPP1(1), SHC1(4), SHC3(1), SORBS1(2), SOS1(7), SRC(2), TLN1(12), TNS1(12), VAV2(4), VAV3(2), VCL(3), ZYX(1)	159277847	303	226	293	93	20	42	38	110	91	2	0.681	1.000	1.000
471	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	92	ADCY1(2), ADCY2(6), ADCY3(5), ADCY4(4), ADCY5(6), ADCY6(3), ADCY7(2), ADCY8(12), ADCY9(8), DRD1(1), DRD2(2), EGF(5), EGFR(10), GJD2(1), GNAI1(3), GNAI2(3), GNAS(5), GRB2(3), GRM1(5), GRM5(8), GUCY1A2(2), GUCY1A3(3), GUCY1B3(3), GUCY2C(5), GUCY2D(3), GUCY2F(6), HRAS(1), HTR2A(1), HTR2B(2), HTR2C(1), ITPR1(11), ITPR2(14), ITPR3(7), KRAS(6), MAP2K2(1), MAP2K5(3), MAP3K2(2), MAPK1(1), MAPK3(3), MAPK7(1), NPR1(5), NPR2(7), NRAS(3), PDGFC(1), PDGFD(3), PDGFRA(6), PDGFRB(3), PLCB1(3), PLCB2(5), PLCB3(4), PLCB4(5), PRKACA(1), PRKACB(2), PRKACG(3), PRKCA(3), PRKCG(5), PRKG1(5), PRKG2(4), PRKX(2), RAF1(5), SOS1(7), SOS2(7), SRC(2), TJP1(5), TUBA1A(2), TUBA3C(1), TUBA3D(3), TUBA4A(5), TUBA8(1), TUBAL3(4), TUBB(3), TUBB1(3), TUBB2B(2), TUBB8(4)	155445603	294	221	286	94	35	48	33	111	67	0	0.748	1.000	1.000
472	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	95	ADCY1(2), ADCY2(6), ADCY3(5), ADCY4(4), ADCY5(6), ADCY6(3), ADCY7(2), ADCY8(12), ADCY9(8), ATF4(2), CACNA1C(15), CACNA1D(12), CACNA1F(4), CACNA1S(14), CALM2(1), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CDC42(1), CGA(1), EGFR(10), ELK1(2), GNAS(5), GRB2(3), HRAS(1), ITPR1(11), ITPR2(14), ITPR3(7), JUN(2), KRAS(6), MAP2K2(1), MAP2K3(3), MAP2K7(3), MAP3K1(8), MAP3K2(2), MAP3K3(3), MAP3K4(9), MAPK1(1), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(2), MAPK3(3), MAPK7(1), MAPK9(2), MMP14(1), MMP2(6), NRAS(3), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(5), PLCB1(3), PLCB2(5), PLCB3(4), PLCB4(5), PLD1(3), PLD2(5), PRKACA(1), PRKACB(2), PRKACG(3), PRKCA(3), PRKCD(5), PRKX(2), PTK2B(4), RAF1(5), SOS1(7), SOS2(7), SRC(2)	151993866	296	219	287	95	38	50	33	108	67	0	0.595	1.000	1.000
473	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADA(1), ADCY1(2), ADCY2(6), ADCY3(5), ADCY4(4), ADCY5(6), ADCY6(3), ADCY7(2), ADCY8(12), ADK(2), ADSL(2), AK2(3), AK5(2), ALLC(3), AMPD1(2), AMPD2(4), AMPD3(4), ATIC(3), ATP1B1(7), ATP5A1(4), ATP5B(3), ATP5C1(2), ATP5F1(1), ATP5G1(1), ATP5G2(3), ATP5G3(1), ATP5H(1), CANT1(1), DCK(1), ENPP1(2), ENPP3(2), ENTPD2(1), GART(4), GDA(4), GMPS(1), GUCY1A2(2), GUCY1A3(3), GUCY1B3(3), GUCY2C(5), GUCY2D(3), GUCY2F(6), HPRT1(1), IMPDH1(1), NPR1(5), NPR2(7), NT5C(1), NT5M(3), NUDT2(1), PAPSS1(3), PAPSS2(4), PDE1A(1), PDE4A(3), PDE4B(1), PDE4C(7), PDE4D(1), PDE5A(1), PDE6B(6), PDE6C(2), PDE7B(1), PDE8A(2), PDE9A(10), PFAS(4), PKLR(1), POLB(2), POLD1(8), POLD2(1), POLE(6), POLG(6), POLL(3), POLQ(12), POLR1B(4), POLR2A(11), POLR2B(6), POLR2C(1), POLR2D(1), POLR2F(4), POLR2I(1), POLR2K(1), POLRMT(5), PPAT(3), PRPS1(1), PRPS1L1(2), PRPS2(4), PRUNE(3), RRM1(4), RRM2(1)	151042938	283	217	272	57	29	36	32	98	88	0	0.0324	1.000	1.000
474	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	73	CALM2(1), CDS2(1), DGKA(4), DGKB(2), DGKD(4), DGKE(5), DGKG(6), DGKH(6), DGKI(1), DGKQ(3), DGKZ(3), FN3K(1), IMPA1(1), IMPA2(3), INPP4A(3), INPP4B(3), INPP5A(1), INPP5B(5), INPP5D(2), INPP5E(2), INPPL1(4), ITPK1(3), ITPKA(1), ITPKB(3), ITPR1(11), ITPR2(14), ITPR3(7), OCRL(3), PI4KA(11), PI4KB(3), PIK3C2A(8), PIK3C2B(5), PIK3C2G(5), PIK3C3(4), PIK3CA(16), PIK3CB(6), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(6), PIP4K2A(3), PIP4K2B(2), PIP4K2C(3), PIP5K1A(2), PIP5K1C(3), PLCB1(3), PLCB2(5), PLCB3(4), PLCB4(5), PLCD1(3), PLCD3(1), PLCD4(3), PLCE1(5), PLCG1(3), PLCG2(3), PLCZ1(4), PRKCA(3), PRKCG(5), PTEN(35), PTPMT1(1), SYNJ1(5), SYNJ2(6)	148201525	289	214	278	79	28	45	30	90	91	5	0.357	1.000	1.000
475	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	126	BID(2), BRAF(6), CD48(1), FAS(2), FASLG(2), FYN(2), GRB2(3), HCST(1), HLA-A(6), HLA-B(9), HLA-C(13), HLA-E(2), HRAS(1), ICAM1(3), IFNA1(1), IFNA14(1), IFNA16(1), IFNA2(2), IFNA21(3), IFNA5(1), IFNA7(3), IFNA8(2), IFNAR1(3), IFNB1(2), IFNG(2), IFNGR1(3), IFNGR2(2), ITGAL(6), ITGB2(2), KIR2DL3(1), KIR3DL1(3), KLRC1(2), KLRC2(3), KLRC3(2), KLRK1(3), KRAS(6), LCK(1), LCP2(2), MAP2K2(1), MAPK1(1), MAPK3(3), MICA(2), MICB(3), NCR1(1), NFAT5(9), NFATC1(4), NFATC2(6), NFATC3(8), NFATC4(3), NRAS(3), PAK1(4), PIK3CA(16), PIK3CB(6), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(6), PLCG1(3), PLCG2(3), PPP3CA(2), PPP3CB(1), PPP3CC(3), PRF1(1), PRKCA(3), PRKCG(5), PTK2B(4), PTPN11(1), PTPN6(3), RAC2(1), RAC3(1), RAF1(5), SH2D1B(1), SH3BP2(3), SHC1(4), SHC2(2), SHC3(1), SHC4(1), SOS1(7), SOS2(7), SYK(2), TNF(1), TNFRSF10B(1), TNFRSF10C(2), TNFRSF10D(1), TNFSF10(9), ULBP1(1), ULBP2(1), VAV1(6), VAV2(4), VAV3(2), ZAP70(1)	132096817	294	214	275	63	26	49	37	110	70	2	0.0282	1.000	1.000
476	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	BRAF(6), CACNA1A(14), CRH(1), CRHR1(2), GNA12(1), GNA13(6), GNAI1(3), GNAI2(3), GNAO1(1), GNAS(5), GNAZ(4), GRIA1(9), GRIA2(5), GRIA3(2), GRID2(8), GRM1(5), GRM5(8), GUCY1A2(2), GUCY1A3(3), GUCY1B3(3), GUCY2C(5), GUCY2D(3), GUCY2F(6), HRAS(1), IGF1R(4), ITPR1(11), ITPR2(14), ITPR3(7), KRAS(6), LYN(3), MAP2K2(1), MAPK1(1), MAPK3(3), NOS1(10), NOS3(3), NPR1(5), NPR2(7), NRAS(3), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(5), PLCB1(3), PLCB2(5), PLCB3(4), PLCB4(5), PPP2CA(1), PPP2CB(1), PPP2R1A(3), PPP2R1B(2), PPP2R2A(6), PPP2R2B(3), PPP2R2C(2), PRKCA(3), PRKCG(5), PRKG1(5), PRKG2(4), RAF1(5), RYR1(23)	130512298	274	214	267	73	43	30	25	106	69	1	0.251	1.000	1.000
477	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	78	ABL1(6), ACTN1(1), ACTR2(2), ACTR3(1), AKT1(1), AKT2(4), AKT3(2), ARHGEF6(3), ARHGEF7(6), BCAR1(5), BRAF(6), CDC42(1), CDKN2A(4), CSE1L(5), DOCK1(2), EPHB2(3), FYN(2), GRB2(3), GRB7(6), ILK(4), ITGA1(8), ITGA10(6), ITGA11(6), ITGA2(3), ITGA3(6), ITGA4(3), ITGA5(7), ITGA6(7), ITGA7(6), ITGA8(2), ITGA9(3), ITGB3BP(1), MAP2K7(3), MAP3K11(1), MAPK1(1), MAPK10(2), MAPK8IP1(4), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2), MRAS(1), MYLK(5), MYLK2(1), P4HB(2), PAK1(4), PAK2(4), PAK3(2), PAK4(5), PAK6(4), PAK7(3), PIK3CA(16), PIK3CB(6), PKLR(1), PLCG1(3), PLCG2(3), PTEN(35), PTK2(3), RAF1(5), RALA(3), RHO(1), ROCK1(7), ROCK2(3), SHC1(4), SOS1(7), SOS2(7), SRC(2), TERF2IP(1), TLN1(12), TLN2(12), WAS(1), ZYX(1)	144169978	304	214	290	73	18	46	36	101	96	7	0.145	1.000	1.000
478	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	57	ASH1L(8), ASH2L(2), CTCFL(7), DOT1L(8), EHMT1(4), EHMT2(8), EZH1(4), EZH2(4), FBXO11(5), HCFC1(10), HSF4(3), JMJD4(1), JMJD6(5), KDM6A(13), MEN1(1), NSD1(12), OGT(6), PAXIP1(4), PPP1CC(2), PRDM2(8), PRDM6(2), PRDM7(3), PRDM9(6), PRMT1(1), PRMT5(5), PRMT6(2), PRMT7(3), PRMT8(3), RBBP5(4), SATB1(3), SETD1A(9), SETD1B(1), SETD2(71), SETD7(1), SETDB1(8), SETDB2(1), SETMAR(3), SMYD3(2), SUV39H1(1), SUV39H2(5), SUV420H1(2), SUZ12(6), WHSC1(5), WHSC1L1(5)	143713348	267	212	263	56	17	28	32	78	106	6	0.0576	1.000	1.000
479	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	110	ACTN1(1), ACTN2(3), ACTN4(4), ARHGAP5(5), BCAR1(5), CD99(1), CDC42(1), CDH5(4), CLDN10(2), CLDN11(2), CLDN15(1), CLDN16(2), CLDN18(2), CLDN2(1), CLDN23(1), CLDN3(1), CLDN4(2), CLDN6(1), CLDN7(1), CTNNA1(9), CTNNA2(7), CTNNA3(3), CTNNB1(4), CTNND1(5), CXCR4(1), ESAM(1), EZR(2), F11R(1), GNAI1(3), GNAI2(3), ICAM1(3), ITGA4(3), ITGAL(6), ITGAM(9), ITGB1(6), ITGB2(2), ITK(2), JAM3(3), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(2), MLLT4(12), MMP2(6), MMP9(1), MSN(3), MYL2(1), MYL7(2), MYL9(1), NCF1(1), NCF2(2), NCF4(1), NOX1(7), NOX3(6), OCLN(3), PIK3CA(16), PIK3CB(6), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(6), PLCG1(3), PLCG2(3), PRKCA(3), PRKCG(5), PTK2(3), PTK2B(4), PTPN11(1), PXN(3), RAC2(1), RAP1A(1), RAPGEF3(2), RAPGEF4(3), ROCK1(7), ROCK2(3), SIPA1(4), THY1(1), VAV1(6), VAV2(4), VAV3(2), VCAM1(5), VCL(3)	146700006	274	204	260	81	32	37	33	97	74	1	0.613	1.000	1.000
480	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	82	ACVR1(1), ACVR1B(4), ACVRL1(1), AKT1(1), BMPR1A(2), BMPR2(6), BUB1(1), CDKL1(1), CDKL2(4), CDS2(1), CLK1(5), CLK2(3), CLK4(8), COL4A3BP(4), CSNK2A1(3), CSNK2A2(2), CSNK2B(1), DGKA(4), DGKB(2), DGKD(4), DGKE(5), DGKG(6), DGKH(6), DGKQ(3), DGKZ(3), IMPA1(1), INPP4A(3), INPP4B(3), INPP5A(1), INPPL1(4), ITPKA(1), ITPKB(3), MAP3K10(4), MOS(1), NEK1(4), NEK3(4), OCRL(3), PAK4(5), PIK3C2A(8), PIK3C2B(5), PIK3C2G(5), PIK3CA(16), PIK3CB(6), PIK3CG(4), PLCB1(3), PLCB2(5), PLCB3(4), PLCB4(5), PLCD1(3), PLCG1(3), PLCG2(3), PLK3(3), PRKACA(1), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4), PRKCA(3), PRKCD(5), PRKCE(4), PRKCG(5), PRKCH(4), PRKCQ(4), PRKCZ(1), PRKD1(3), PRKG1(5), RAF1(5), RPS6KA1(7), RPS6KA3(2), RPS6KA4(2), RPS6KB1(2), STK11(2), TGFBR1(1), VRK1(1)	134166200	260	202	248	56	21	40	29	83	86	1	0.0410	1.000	1.000
481	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(1), ACTA2(1), ACTN2(3), ACTN4(4), DES(1), DMD(16), MYBPC1(5), MYBPC2(3), MYBPC3(3), MYH3(7), MYH6(8), MYH7(15), MYH8(8), MYL1(3), MYL2(1), MYL4(1), MYL9(1), MYOM1(6), NEB(18), TCAP(1), TMOD1(6), TNNI1(2), TNNT1(3), TNNT2(1), TNNT3(1), TPM2(1), TPM3(1), TPM4(1), TTN(125), VIM(2)	164621760	249	202	243	78	20	37	34	101	53	4	0.725	1.000	1.000
482	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	99	ADCY1(2), ADCY2(6), ADCY3(5), ADCY4(4), ADCY5(6), ADCY6(3), ADCY7(2), ADCY8(12), ADCY9(8), ASIP(2), CALM2(1), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CREB1(1), CREB3L1(3), CREB3L2(1), CREB3L3(1), CREB3L4(3), CREBBP(13), CTNNB1(4), DCT(5), DVL1(1), DVL2(1), DVL3(1), EDNRB(3), EP300(16), FZD1(2), FZD10(3), FZD2(3), FZD3(1), FZD4(4), FZD5(3), FZD7(3), FZD8(2), GNAI1(3), GNAI2(3), GNAO1(1), GNAS(5), GSK3B(3), HRAS(1), KITLG(2), KRAS(6), LEF1(3), MAP2K2(1), MAPK1(1), MAPK3(3), MC1R(2), MITF(4), NRAS(3), PLCB1(3), PLCB2(5), PLCB3(4), PLCB4(5), POMC(2), PRKACA(1), PRKACB(2), PRKACG(3), PRKCA(3), PRKCG(5), PRKX(2), RAF1(5), TCF7L1(3), TCF7L2(1), TYR(5), TYRP1(4), WNT1(2), WNT10A(3), WNT11(1), WNT2(3), WNT2B(3), WNT3(2), WNT3A(1), WNT5B(2), WNT7A(1), WNT7B(2), WNT8A(2), WNT8B(1), WNT9B(3)	125714313	253	198	242	72	33	36	27	93	64	0	0.294	1.000	1.000
483	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY1(2), ADCY2(6), ADCY3(5), ADCY4(4), ADCY5(6), ADCY6(3), ADCY7(2), ADCY8(12), ADCY9(8), AKAP1(3), AKAP10(2), AKAP11(3), AKAP12(8), AKAP2(2), AKAP3(3), AKAP4(3), AKAP6(6), AKAP7(1), AKAP8(2), AKAP9(20), ARHGEF1(2), CALM2(1), CHMP1B(3), GNA12(1), GNA13(6), GNA14(1), GNA15(1), GNAI2(3), GNAO1(1), GNAZ(4), GNB1(3), GNB3(2), GNB5(3), GNG10(1), GNG12(1), GNG13(1), GNG3(1), GNG7(1), HRAS(1), IL18BP(1), ITPR1(11), KCNJ3(4), KRAS(6), NRAS(3), PALM2(1), PDE1A(1), PDE1B(6), PDE1C(3), PDE4A(3), PDE4B(1), PDE4C(7), PDE4D(1), PDE7A(1), PDE7B(1), PDE8A(2), PDE8B(3), PLCB3(4), PPP3CA(2), PPP3CC(3), PRKACA(1), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4), PRKCA(3), PRKCD(5), PRKCE(4), PRKCG(5), PRKCH(4), PRKCI(5), PRKCQ(4), PRKCZ(1), PRKD1(3), PRKD3(4), SLC9A1(3), USP5(4)	137815972	260	196	250	75	24	38	17	103	77	1	0.611	1.000	1.000
484	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	85	ABL1(6), ABL2(5), AKT1(1), AKT2(4), AKT3(2), AREG(1), BRAF(6), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CBL(2), CBLB(5), CBLC(2), CDKN1A(3), CDKN1B(1), EGF(5), EGFR(10), ELK1(2), ERBB2(8), ERBB3(7), ERBB4(11), GAB1(1), GRB2(3), GSK3B(3), HRAS(1), JUN(2), KRAS(6), MAP2K2(1), MAP2K7(3), MAPK1(1), MAPK10(2), MAPK3(3), MAPK9(2), MYC(1), NCK1(1), NCK2(1), NRAS(3), NRG1(4), NRG2(3), NRG3(5), PAK1(4), PAK2(4), PAK3(2), PAK4(5), PAK6(4), PAK7(3), PIK3CA(16), PIK3CB(6), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(6), PLCG1(3), PLCG2(3), PRKCA(3), PRKCG(5), PTK2(3), RAF1(5), RPS6KB1(2), RPS6KB2(3), SHC1(4), SHC2(2), SHC3(1), SHC4(1), SOS1(7), SOS2(7), SRC(2), STAT5A(4), STAT5B(4)	120995706	259	195	239	53	23	43	36	94	61	2	0.00887	1.000	1.000
485	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	162	ADORA2A(5), ADORA2B(1), ADORA3(2), ADRA1A(4), ADRA2A(1), ADRB2(2), AGTR1(2), AGTR2(1), AVPR1A(1), AVPR2(2), BDKRB1(1), BDKRB2(1), BRS3(2), C3AR1(4), CCKAR(4), CCKBR(3), CCR10(1), CCR2(2), CCR3(1), CCR5(1), CCR6(1), CCR7(1), CCR9(3), CHML(1), CHRM1(2), CHRM2(5), CHRM3(3), CHRM5(2), CMKLR1(1), CNR1(1), CNR2(3), CX3CR1(1), CXCR4(1), DRD1(1), DRD2(2), DRD3(3), DRD5(3), EDNRB(3), F2R(2), F2RL1(1), F2RL2(2), F2RL3(1), FPR1(2), FSHR(2), GALR1(1), GALT(3), GPR17(2), GPR173(3), GPR174(4), GPR27(1), GPR3(1), GPR35(3), GPR37(5), GPR37L1(2), GPR4(1), GPR50(3), GPR63(1), GPR83(2), GPR85(3), GPR87(4), GRPR(2), HCRTR1(3), HCRTR2(4), HRH2(1), HRH3(1), HTR1A(3), HTR1B(1), HTR1D(2), HTR1E(3), HTR1F(2), HTR2A(1), HTR2B(2), HTR2C(1), HTR4(2), HTR6(1), HTR7(2), LHCGR(1), MAS1(2), MC1R(2), MC3R(2), MC4R(1), MC5R(1), MLNR(1), MTNR1B(1), NMUR2(4), NPY1R(2), NPY2R(3), NTSR1(2), OPN1SW(2), OPRD1(3), OPRK1(2), OPRL1(1), OPRM1(4), OR11A1(1), OR12D3(1), OR1C1(1), OR1F1(1), OR1Q1(1), OR5V1(4), OR7A5(2), OR7C1(2), OR8B8(3), OXTR(1), P2RY1(3), P2RY10(1), P2RY11(1), P2RY12(1), P2RY13(1), P2RY14(1), P2RY2(2), PTAFR(1), PTGDR(1), PTGER2(1), PTGER4(1), PTGFR(5), PTGIR(1), RHO(1), SSTR1(3), SSTR2(2), SSTR3(1), SSTR4(1), TBXA2R(4), TRHR(2)	137312441	243	193	241	84	37	32	33	99	42	0	0.573	1.000	1.000
486	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	83	AGL(7), AMY1A(2), AMY1B(4), AMY1C(2), AMY2A(1), AMY2B(2), ASCC3(7), ATP13A2(8), DDX18(4), DDX23(3), DDX4(6), DDX41(2), DDX47(2), DDX50(8), DDX52(2), DDX54(3), DDX55(4), DDX56(2), DHX58(3), ENPP1(2), ENPP3(2), ENTPD7(3), EP400(14), ERCC2(1), ERCC3(3), G6PC(3), GAA(4), GANC(4), GBA(2), GBE1(1), GCK(1), GPI(3), GUSB(5), GYS1(3), GYS2(2), HK1(7), IFIH1(2), MGAM(8), MOV10L1(8), NUDT5(4), PGM1(1), PYGB(3), PYGL(1), PYGM(4), RAD54B(1), RAD54L(2), RUVBL2(2), SETX(12), SI(9), SKIV2L2(2), SMARCA2(6), SMARCA5(3), UGDH(1), UGP2(1), UGT1A1(5), UGT1A10(1), UGT1A3(2), UGT1A4(3), UGT1A5(4), UGT1A6(5), UGT1A7(4), UGT1A9(6), UGT2A1(5), UGT2A3(2), UGT2B11(2), UGT2B15(1), UGT2B28(4), UGT2B4(4), UGT2B7(6), UXS1(1)	151904382	257	192	250	81	17	32	45	84	78	1	0.832	1.000	1.000
487	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(9), ABCA10(8), ABCA12(13), ABCA13(21), ABCA2(3), ABCA3(4), ABCA4(10), ABCA5(8), ABCA6(4), ABCA7(15), ABCA8(7), ABCA9(3), ABCB1(6), ABCB10(1), ABCB11(4), ABCB4(7), ABCB5(6), ABCB6(4), ABCB7(1), ABCB8(2), ABCB9(1), ABCC1(11), ABCC10(6), ABCC11(6), ABCC12(4), ABCC2(5), ABCC3(10), ABCC4(7), ABCC5(5), ABCC6(10), ABCC8(5), ABCC9(4), ABCD1(3), ABCD2(2), ABCD3(3), ABCD4(4), ABCG1(2), ABCG2(1), ABCG4(8), ABCG5(2), ABCG8(5), CFTR(6), TAP2(1)	139457686	247	187	236	78	16	34	33	96	67	1	0.725	1.000	1.000
488	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	67	ADCY1(2), ADCY8(12), ATF4(2), BRAF(6), CACNA1C(15), CALM2(1), CAMK2A(1), CAMK2B(3), CAMK2D(2), CAMK2G(2), CAMK4(3), CREBBP(13), EP300(16), GRIA1(9), GRIA2(5), GRIN1(2), GRIN2A(10), GRIN2B(8), GRIN2D(3), GRM1(5), GRM5(8), HRAS(1), ITPR1(11), ITPR2(14), ITPR3(7), KRAS(6), MAP2K2(1), MAPK1(1), MAPK3(3), NRAS(3), PLCB1(3), PLCB2(5), PLCB3(4), PLCB4(5), PPP1CC(2), PPP1R12A(4), PPP1R1A(1), PPP3CA(2), PPP3CB(1), PPP3CC(3), PRKACA(1), PRKACB(2), PRKACG(3), PRKCA(3), PRKCG(5), PRKX(2), RAF1(5), RAP1A(1), RAPGEF3(2), RPS6KA1(7), RPS6KA3(2), RPS6KA6(1)	118964286	239	187	223	61	29	32	28	85	63	2	0.165	1.000	1.000
489	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	82	ABL1(6), ATM(23), BUB1(1), BUB1B(2), BUB3(1), CCNA1(7), CCNA2(1), CCNB2(6), CCNB3(4), CCND2(1), CCND3(1), CCNE1(1), CCNE2(4), CCNH(1), CDAN1(7), CDC14A(6), CDC20(3), CDC25A(2), CDC25B(1), CDC25C(4), CDC6(3), CDC7(1), CDH1(3), CDK2(2), CDK4(7), CDKN1A(3), CDKN2A(4), CHEK1(1), CHEK2(3), DTX4(4), E2F1(1), E2F2(1), E2F3(1), E2F5(2), EP300(16), ESPL1(11), GSK3B(3), HDAC1(2), HDAC4(1), HDAC5(3), HDAC6(4), HDAC8(1), MAD1L1(1), MAD2L1(1), MCM2(9), MCM3(2), MCM4(1), MCM5(3), MCM6(6), MCM7(5), MPEG1(1), PCNA(3), PLK1(1), PRKDC(10), PTPRA(5), RB1(4), SKP2(2), SMAD4(4), TBC1D8(1), TP53(50), WEE1(2)	130833512	270	183	248	60	21	33	42	79	87	8	0.0173	1.000	1.000
490	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CD2BP2(1), CDC40(3), CLK2(3), CLK3(2), CLK4(8), COL2A1(7), CPSF1(3), CPSF2(3), CPSF3(5), CPSF4(2), CSTF1(1), CSTF2T(2), CSTF3(4), DDX1(1), DDX20(8), DHX15(3), DHX16(4), DHX38(3), DHX8(6), DHX9(7), DICER1(6), FUS(5), GIPC1(2), METTL3(6), NCBP2(1), NONO(2), NUDT21(2), NXF1(5), PABPN1(1), PAPOLA(3), PHF5A(1), POLR2A(11), PPM1G(3), PRPF18(3), PRPF3(2), PRPF4B(5), PRPF8(15), PSKH1(1), PTBP1(1), PTBP2(2), RBM17(2), RBM5(3), RNGTT(1), RNMT(3), SF3A1(3), SF3A3(2), SF3B1(14), SF3B2(4), SNRPA(1), SNRPA1(1), SNRPB(2), SNRPB2(1), SNRPE(1), SNRPN(2), SNURF(1), SPOP(1), SRPK1(1), SRPK2(3), SRRM1(4), SUPT5H(7), TXNL4A(1), U2AF2(4), XRN2(3)	124661384	218	183	214	49	16	41	25	79	56	1	0.0842	1.000	1.000
491	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	108	A4GNT(3), ALG1(1), ALG10(3), ALG10B(8), ALG11(5), ALG12(2), ALG13(4), ALG14(2), ALG2(1), ALG3(3), ALG6(3), ALG8(1), ALG9(3), B3GNT1(2), B3GNT2(4), B3GNT6(3), B3GNT7(1), B4GALT1(2), B4GALT2(1), B4GALT3(2), B4GALT4(2), B4GALT5(3), CHST1(2), CHST11(1), CHST12(2), CHST13(1), CHST14(1), CHST2(4), CHST3(2), CHST4(1), CHST6(1), CHST7(1), CHSY1(9), DPAGT1(8), EXT1(3), EXT2(3), EXTL1(2), EXTL2(7), EXTL3(3), FUT11(3), GALNT1(1), GALNT10(6), GALNT11(3), GALNT13(3), GALNT14(2), GALNT2(2), GALNT4(4), GALNT5(6), GALNT6(6), GALNT7(9), GALNT8(1), GALNT9(1), GALNTL5(2), GCNT1(2), GCNT3(2), GCNT4(2), HS2ST1(2), HS3ST1(1), HS3ST2(2), HS3ST3A1(1), HS3ST5(1), HS6ST1(3), HS6ST2(2), HS6ST3(1), MAN1A1(2), MAN1A2(1), MAN1B1(2), MAN1C1(2), MAN2A1(5), MGAT4A(3), MGAT4B(2), MGAT5(4), MGAT5B(4), NDST1(3), NDST2(4), NDST4(9), OGT(6), RPN1(4), RPN2(2), ST3GAL1(2), ST3GAL3(3), ST3GAL4(2), ST6GAL1(1), ST6GALNAC1(2), STT3B(4), WBSCR17(4), XYLT1(4), XYLT2(2)	127816532	255	182	238	69	18	39	25	79	94	0	0.581	1.000	1.000
492	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	88	ACVR1(1), ACVR1B(4), ACVR1C(3), ACVR2A(5), ACVR2B(1), ACVRL1(1), AMHR2(9), BMP2(1), BMP4(2), BMP5(1), BMP6(1), BMP7(5), BMP8A(5), BMP8B(1), BMPR1A(2), BMPR1B(1), BMPR2(6), CHRD(5), CREBBP(13), CUL1(5), DCN(3), E2F5(2), EP300(16), GDF5(3), GDF6(2), GDF7(1), IFNG(2), INHBA(2), INHBB(2), INHBC(1), INHBE(2), LEFTY2(1), LTBP1(8), MAPK1(1), MAPK3(3), MYC(1), NODAL(2), NOG(1), PITX2(2), PPP2CA(1), PPP2CB(1), PPP2R1A(3), PPP2R1B(2), PPP2R2A(6), PPP2R2B(3), PPP2R2C(2), RBL2(3), RBX1(1), ROCK1(7), ROCK2(3), RPS6KB1(2), RPS6KB2(3), SMAD1(1), SMAD2(3), SMAD3(2), SMAD4(4), SMAD5(1), SMAD7(1), SMAD9(2), SMURF1(1), SMURF2(4), SP1(2), TGFB2(2), TGFBR1(1), TGFBR2(1), THBS1(16), THBS2(3), THBS3(5), THBS4(4), TNF(1), ZFYVE16(3), ZFYVE9(7)	115326172	228	178	215	50	20	17	38	74	79	0	0.125	1.000	1.000
493	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	69	A2M(10), BDKRB1(1), BDKRB2(1), C1QA(1), C1QC(1), C1R(4), C1S(16), C2(5), C3(9), C3AR1(4), C4A(1), C4BPA(3), C4BPB(3), C5(7), C5AR1(2), C6(3), C7(4), C8A(3), C8B(2), C8G(2), C9(1), CD46(1), CD55(2), CFB(2), CFH(5), CFI(1), CPB2(6), CR1(11), CR2(4), F10(1), F11(2), F12(9), F13A1(3), F13B(3), F2(4), F2R(2), F5(11), F7(1), F8(7), F9(3), FGA(4), FGB(3), FGG(6), KLKB1(2), KNG1(5), MASP1(5), MASP2(2), MBL2(2), PLAT(4), PLAUR(2), PLG(6), PROC(3), PROS1(5), SERPINA1(3), SERPIND1(3), SERPINF2(2), SERPING1(2), TFPI(1), VWF(15)	114736895	236	175	215	49	23	29	25	97	59	3	0.0240	1.000	1.000
494	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	91	ACTB(4), CABIN1(11), CALM2(1), CAMK2B(3), CAMK4(3), CD3E(1), CD3G(2), CDKN1A(3), CNR1(1), CREBBP(13), CSNK2A1(3), CSNK2B(1), CTLA4(1), EGR2(1), EGR3(2), EP300(16), FCER1A(1), FKBP1B(1), FOS(1), GATA3(3), GATA4(2), GSK3A(1), GSK3B(3), HRAS(1), ICOS(3), IFNA1(1), IFNB1(2), IFNG(2), IL1B(1), IL2(1), IL2RA(2), IL3(1), IL4(1), ITK(2), JUNB(2), KPNA5(2), MAP2K7(3), MAPK14(2), MAPK9(2), MEF2A(2), MEF2D(1), NCK2(1), NFAT5(9), NFATC1(4), NFATC2(6), NFATC3(8), NFATC4(3), NFKB2(3), NFKBIB(2), NPPB(1), NUP214(9), OPRD1(3), P2RX7(2), PAK1(4), PPIA(1), PPP3CB(1), PPP3CC(3), PTPRC(7), RELA(7), SFN(1), SLA(1), SP1(2), SP3(3), TNF(1), TRAF2(1), TRPV6(5), VAV1(6), VAV2(4), VAV3(2), XPO5(5)	105905814	214	166	203	53	22	21	34	69	66	2	0.307	1.000	1.000
495	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	ACTR2(2), ACTR3(1), AKT1(1), AKT2(4), AKT3(2), ARHGAP1(1), ARHGEF11(6), CDC42(1), CFL1(1), CFL2(1), GDI2(2), INPPL1(4), ITPR1(11), ITPR2(14), ITPR3(7), LIMK1(6), MYLK(5), MYLK2(1), PAK1(4), PAK2(4), PAK3(2), PAK4(5), PAK6(4), PAK7(3), PDK1(1), PIK3CA(16), PIK3CD(2), PIK3CG(4), PIK3R1(5), PITX2(2), PPP1R13B(6), PTEN(35), RACGAP1(2), RHO(1), ROCK1(7), ROCK2(3), SAG(5), WASF1(1), WASL(9)	82649431	191	160	182	36	15	34	20	57	61	4	0.0100	1.000	1.000
496	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	84	ANPEP(11), CD19(1), CD1A(2), CD1B(1), CD1C(3), CD1D(3), CD1E(2), CD2(2), CD22(4), CD33(4), CD34(2), CD38(1), CD3E(1), CD3G(2), CD4(10), CD44(3), CD5(2), CD55(2), CD7(2), CD8A(1), CD9(1), CR1(11), CR2(4), CSF1R(8), CSF2RA(3), CSF3R(3), DNTT(4), EPOR(1), FCER2(1), FCGR1A(1), FLT3(7), HLA-DRA(1), HLA-DRB1(6), HLA-DRB5(8), IL11RA(2), IL1B(1), IL1R1(3), IL1R2(7), IL2RA(2), IL3(1), IL4(1), IL4R(5), IL5RA(1), IL6R(2), IL7R(1), IL9R(4), ITGA1(8), ITGA2(3), ITGA2B(2), ITGA3(6), ITGA4(3), ITGA5(7), ITGA6(7), ITGAM(9), ITGB3(4), KITLG(2), MME(6), MS4A1(1), TFRC(4), THPO(1), TNF(1), TPO(4)	96959195	216	159	201	47	16	21	30	71	76	2	0.200	1.000	1.000
497	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	99	AKT1(1), AKT2(4), AKT3(2), CASP8(1), CCL3(1), CD40(1), CD80(1), CD86(3), CHUK(2), CXCL11(1), CXCL9(1), FOS(1), IFNA1(1), IFNA14(1), IFNA16(1), IFNA2(2), IFNA21(3), IFNA5(1), IFNA7(3), IFNA8(2), IFNAR1(3), IFNB1(2), IKBKB(3), IKBKE(3), IL1B(1), IRAK1(3), IRAK4(1), IRF5(3), IRF7(2), JUN(2), LBP(1), LY96(1), MAP2K2(1), MAP2K3(3), MAP2K7(3), MAP3K7(3), MAP3K8(1), MAPK1(1), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(2), MAPK3(3), MAPK9(2), NFKB1(1), NFKB2(3), NFKBIA(1), PIK3CA(16), PIK3CB(6), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(6), RELA(7), RIPK1(2), SPP1(3), STAT1(6), TBK1(4), TICAM1(3), TLR1(4), TLR2(3), TLR3(2), TLR4(2), TLR5(5), TLR6(2), TLR7(5), TLR8(5), TLR9(1), TNF(1), TRAF3(1), TRAF6(2)	104704940	188	155	177	38	20	28	23	78	38	1	0.0287	1.000	1.000
498	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	85	ATF2(3), BRAF(6), CEBPA(2), CHUK(2), CREB1(1), DAXX(6), ELK1(2), FOS(1), GRB2(3), HRAS(1), IKBKB(3), JUN(2), MAP2K2(1), MAP2K3(3), MAP2K5(3), MAP2K7(3), MAP3K1(8), MAP3K10(4), MAP3K11(1), MAP3K12(5), MAP3K13(2), MAP3K2(2), MAP3K3(3), MAP3K4(9), MAP3K5(5), MAP3K6(5), MAP3K7(3), MAP3K8(1), MAP3K9(4), MAP4K1(3), MAP4K2(2), MAP4K3(4), MAP4K4(2), MAP4K5(4), MAPK1(1), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(2), MAPK3(3), MAPK4(2), MAPK6(2), MAPK7(1), MAPK9(2), MAPKAPK2(2), MAX(5), MEF2A(2), MEF2C(1), MEF2D(1), MKNK1(2), MKNK2(2), MYC(1), NFKB1(1), NFKBIA(1), PAK1(4), PAK2(4), RAF1(5), RELA(7), RIPK1(2), RPS6KA1(7), RPS6KA3(2), RPS6KA4(2), RPS6KA5(3), RPS6KB1(2), RPS6KB2(3), SHC1(4), SP1(2), STAT1(6), TGFB2(2), TGFBR1(1), TRADD(2), TRAF2(1)	113581029	204	153	194	44	19	19	23	71	69	3	0.203	1.000	1.000
499	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	47	FN3K(1), IMPA1(1), IMPA2(3), INPP4A(3), INPP4B(3), INPP5A(1), INPP5B(5), INPP5E(2), INPPL1(4), IPMK(1), ITPK1(3), ITPKA(1), ITPKB(3), MINPP1(2), MIOX(2), OCRL(3), PI4KA(11), PI4KB(3), PIK3C3(4), PIK3CA(16), PIK3CB(6), PIK3CD(2), PIK3CG(4), PIP4K2A(3), PIP4K2B(2), PIP4K2C(3), PIP5K1A(2), PIP5K1C(3), PLCB1(3), PLCB2(5), PLCB3(4), PLCB4(5), PLCD1(3), PLCD3(1), PLCD4(3), PLCE1(5), PLCG1(3), PLCG2(3), PLCZ1(4), PTEN(35), PTPMT1(1), SYNJ1(5), SYNJ2(6)	87420680	183	149	173	51	13	25	18	56	66	5	0.655	1.000	1.000
500	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	70	ACACB(5), ACSL1(2), ACSL3(13), ACSL4(1), ACSL5(1), ACSL6(5), AKT1(1), AKT2(4), AKT3(2), CAMKK1(5), CAMKK2(3), CHUK(2), CPT1A(3), CPT1B(1), CPT1C(5), CPT2(2), G6PC(3), IKBKB(3), IRS1(6), IRS4(1), JAK1(6), JAK2(7), JAK3(4), LEP(1), LEPR(5), MAPK10(2), MAPK9(2), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIB(2), NPY(1), PCK1(9), PCK2(2), POMC(2), PPARGC1A(3), PRKAA1(2), PRKAA2(4), PRKAB1(1), PRKAG1(6), PRKAG2(7), PRKAG3(1), PRKCQ(4), PTPN11(1), RELA(7), RXRA(2), RXRB(5), RXRG(2), SLC2A1(1), SLC2A4(3), SOCS3(2), STAT3(4), STK11(2), TNF(1), TNFRSF1A(1), TNFRSF1B(2), TRADD(2), TRAF2(1), TYK2(7)	96096586	187	148	168	42	14	24	33	59	56	1	0.155	1.000	1.000
501	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	63	AKT1(1), AKT2(4), AKT3(2), BCL10(2), BLNK(1), CARD11(9), CD19(1), CD22(4), CD72(1), CD81(1), CHUK(2), CR2(4), FOS(1), GSK3B(3), HRAS(1), IFITM1(1), IKBKB(3), INPP5D(2), JUN(2), KRAS(6), LILRB3(4), LYN(3), MALT1(2), NFAT5(9), NFATC1(4), NFATC2(6), NFATC3(8), NFATC4(3), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIB(2), NRAS(3), PIK3CA(16), PIK3CB(6), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(6), PLCG2(3), PPP3CA(2), PPP3CB(1), PPP3CC(3), PTPN6(3), RAC2(1), RAC3(1), RASGRP3(2), SYK(2), VAV1(6), VAV2(4), VAV3(2)	87697055	173	146	155	34	18	28	18	66	43	0	0.0243	1.000	1.000
502	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	69	AKT1(1), AKT2(4), AKT3(2), CASP9(2), CDC42(1), HRAS(1), KDR(6), KRAS(6), MAP2K2(1), MAPK1(1), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(2), MAPK3(3), MAPKAPK2(2), NFAT5(9), NFATC1(4), NFATC2(6), NFATC3(8), NFATC4(3), NOS3(3), NRAS(3), PIK3CA(16), PIK3CB(6), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(6), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(5), PLCG1(3), PLCG2(3), PPP3CA(2), PPP3CB(1), PPP3CC(3), PRKCA(3), PRKCG(5), PTGS2(5), PTK2(3), PXN(3), RAC2(1), RAC3(1), RAF1(5), SH2D2A(3), SHC2(2), SPHK1(1), SPHK2(2), SRC(2), VEGFA(1)	84284599	173	140	159	47	16	30	20	64	43	0	0.321	1.000	1.000
503	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	74	AKT1(1), AKT2(4), AKT3(2), FCER1A(1), FYN(2), GAB2(1), GRB2(3), HRAS(1), IL3(1), IL4(1), INPP5D(2), KRAS(6), LCP2(2), LYN(3), MAP2K2(1), MAP2K3(3), MAP2K7(3), MAPK1(1), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(2), MAPK3(3), MAPK9(2), MS4A2(1), NRAS(3), PDK1(1), PIK3CA(16), PIK3CB(6), PIK3CD(2), PIK3CG(4), PIK3R1(5), PIK3R2(3), PIK3R3(1), PIK3R5(6), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(5), PLCG1(3), PLCG2(3), PRKCA(3), PRKCD(5), PRKCE(4), RAC2(1), RAC3(1), RAF1(5), SOS1(7), SOS2(7), SYK(2), TNF(1), VAV1(6), VAV2(4), VAV3(2)	84854486	162	139	150	39	18	32	22	62	28	0	0.0703	1.000	1.000
504	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	AKT1(1), AKT2(4), AKT3(2), BCR(2), BLNK(1), CD19(1), CD22(4), CD81(1), CR2(4), CSK(4), DAG1(3), FLOT1(1), FLOT2(1), GRB2(3), GSK3A(1), GSK3B(3), INPP5D(2), ITPR1(11), ITPR2(14), ITPR3(7), LYN(3), MAP4K1(3), MAPK1(1), MAPK3(3), NFATC1(4), NFATC2(6), PDK1(1), PIK3CA(16), PIK3CD(2), PIK3R1(5), PLCG2(3), PPP1R13B(6), PPP3CA(2), PPP3CB(1), PPP3CC(3), PTPRC(7), RAF1(5), SHC1(4), SOS1(7), SOS2(7), SYK(2), VAV1(6)	86242412	167	138	155	34	18	29	23	57	40	0	0.0171	1.000	1.000
505	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	66	ADAM10(4), ADAM17(3), ATP6AP1(4), ATP6V0A1(5), ATP6V0A2(3), ATP6V0A4(3), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(5), ATP6V1B1(4), ATP6V1B2(5), ATP6V1C1(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1E2(2), ATP6V1G1(1), ATP6V1H(1), CDC42(1), CHUK(2), CSK(4), EGFR(10), F11R(1), GIT1(2), IGSF5(5), IKBKB(3), JAM3(3), JUN(2), LYN(3), MAPK10(2), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(2), MAPK9(2), MET(28), NFKB1(1), NFKB2(3), NFKBIA(1), NOD1(3), PAK1(4), PLCG1(3), PLCG2(3), PTPN11(1), PTPRZ1(15), RELA(7), SRC(2), TCIRG1(1), TJP1(5)	83753173	168	133	149	38	13	21	28	64	40	2	0.156	1.000	1.000
506	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	ADAM17(3), APH1A(2), CREBBP(13), CTBP1(2), CTBP2(1), DLL1(1), DLL3(1), DLL4(2), DTX1(4), DTX3(1), DTX3L(2), DTX4(4), DVL1(1), DVL2(1), DVL3(1), EP300(16), HDAC1(2), JAG1(10), JAG2(3), MAML1(8), MAML2(5), MAML3(7), NCOR2(7), NCSTN(2), NOTCH1(9), NOTCH2(12), NOTCH3(13), NOTCH4(7), NUMB(3), NUMBL(2), PSEN1(1), PSEN2(2), PSENEN(1), PTCRA(1), RBPJ(4), RBPJL(7), SNW1(4)	78961138	165	132	154	65	16	13	20	48	65	3	0.998	1.000	1.000
507	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(7), ATP4A(6), ATP5A1(4), ATP5B(3), ATP5C1(2), ATP5E(1), ATP5F1(1), ATP5G1(1), ATP5G2(3), ATP5G3(1), ATP5H(1), ATP5L(1), ATP6AP1(4), ATP6V0A1(5), ATP6V0A2(3), ATP6V0A4(3), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(5), ATP6V1B1(4), ATP6V1B2(5), ATP6V1C1(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1E2(2), ATP6V1G1(1), ATP6V1H(1), COX10(5), COX15(4), COX17(1), COX5A(1), COX6B2(1), COX7A1(2), COX7C(1), COX8A(1), CYC1(1), NDUFA1(1), NDUFA10(1), NDUFA13(2), NDUFA3(1), NDUFA6(1), NDUFB10(1), NDUFB2(1), NDUFB4(2), NDUFB5(2), NDUFB6(1), NDUFB7(1), NDUFB9(1), NDUFC1(2), NDUFS1(8), NDUFS2(1), NDUFS3(3), NDUFS5(1), NDUFS6(2), NDUFS7(1), NDUFS8(1), NDUFV1(2), NDUFV2(1), PPA1(2), PPA2(2), SDHA(8), SDHB(1), SDHD(2), TCIRG1(1), UQCRC1(2), UQCRC2(4), UQCRFS1(2)	66091202	148	131	147	36	12	16	27	56	36	1	0.221	1.000	1.000
508	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	AICDA(3), CAD(13), CANT1(1), DCK(1), DCTD(1), DPYD(5), DPYS(3), DTYMK(1), DUT(1), ENTPD4(2), ENTPD5(3), ENTPD6(2), ENTPD8(1), NME7(2), NT5C(1), NT5C1A(3), NT5C1B(2), NT5C2(1), NT5M(3), NUDT2(1), PNPT1(4), POLA1(3), POLD1(8), POLD2(1), POLD3(1), POLE(6), POLE2(1), POLR1A(10), POLR1B(4), POLR1C(2), POLR1D(1), POLR2A(11), POLR2B(6), POLR2C(1), POLR2D(1), POLR2F(4), POLR2I(1), POLR2K(1), POLR3A(7), POLR3B(3), POLR3G(2), POLR3GL(1), POLR3H(2), POLR3K(1), PRIM1(2), PRIM2(2), RFC5(2), RRM1(4), RRM2(1), TK1(1), TK2(2), TXNRD1(1), TXNRD2(1), UCK1(1), UCK2(1), UMPS(3), UPB1(2), UPP1(3), UPP2(3), UPRT(3)	96314045	164	131	156	33	12	25	22	50	53	2	0.0389	1.000	1.000
509	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACAA1(4), ACADL(3), ACADM(3), ACOX1(2), ACOX2(4), ACOX3(5), ACSL1(2), ACSL3(13), ACSL4(1), ACSL5(1), ACSL6(5), ANGPTL4(4), APOA1(1), APOA5(2), AQP7(10), CPT1A(3), CPT1B(1), CPT1C(5), CPT2(2), CYP27A1(2), CYP4A11(6), CYP7A1(1), CYP8B1(3), DBI(1), EHHADH(6), FABP1(3), FABP3(1), FADS2(2), GK(2), GK2(3), HMGCS2(3), ILK(4), LPL(6), ME1(1), MMP1(1), NR1H3(2), PCK1(9), PCK2(2), PLTP(2), PPARD(1), PPARG(3), RXRA(2), RXRB(5), RXRG(2), SCP2(3), SLC27A1(2), SLC27A2(1), SLC27A5(3), SLC27A6(6), SORBS1(2), UBC(6), UCP1(1)	76471982	168	130	150	44	11	25	24	64	44	0	0.388	1.000	1.000
510	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ADCY4(4), ADCY6(3), ADCY8(12), CACNA1A(14), CACNA1B(9), GNAS(5), GNB1(3), GNB3(2), GNG13(1), GNG3(1), GRM4(5), ITPR3(7), KCNB1(4), PDE1A(1), PLCB2(5), PRKACA(1), PRKACB(2), PRKACG(3), PRKX(2), SCNN1A(5), SCNN1B(5), SCNN1G(2), TAS1R1(2), TAS1R2(6), TAS1R3(6), TAS2R10(1), TAS2R13(2), TAS2R3(14), TAS2R38(3), TAS2R39(2), TAS2R4(2), TAS2R41(1), TAS2R42(1), TAS2R43(8), TAS2R46(2), TAS2R50(4), TAS2R60(1), TAS2R8(1), TAS2R9(2), TRPM5(3)	66971776	157	130	146	37	30	18	18	59	32	0	0.0796	1.000	1.000
511	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	50	ACOX1(2), APOA1(1), CITED2(2), CPT1B(1), CREBBP(13), DUT(1), EHHADH(6), EP300(16), FABP1(3), HSD17B4(1), HSPA1A(1), INS(1), JUN(2), LPL(6), MAPK1(1), MAPK3(3), ME1(1), MRPL11(1), MYC(1), NCOA1(5), NCOR1(11), NCOR2(7), NFKBIA(1), NR1H3(2), NR2F1(2), NRIP1(6), PIK3CA(16), PIK3R1(5), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4), PRKCA(3), PTGS2(5), RB1(4), RELA(7), RXRA(2), SP1(2), STAT5A(4), STAT5B(4), TNF(1)	74335634	162	130	146	47	10	28	20	50	51	3	0.643	1.000	1.000
512	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	67	APAF1(4), BAX(1), BCL2L11(1), BID(2), BIRC2(3), BIRC3(6), BIRC5(1), CASP1(2), CASP10(3), CASP2(1), CASP4(3), CASP6(1), CASP7(1), CASP8(1), CASP9(2), CHUK(2), DFFA(1), DFFB(1), FAS(2), FASLG(2), HELLS(2), IKBKB(3), IRF2(2), IRF4(1), IRF5(3), IRF6(6), IRF7(2), JUN(2), LTA(1), MAP3K1(8), MAPK10(2), MYC(1), NFKB1(1), NFKBIA(1), NFKBIB(2), PLEKHG5(1), PRF1(1), RELA(7), RIPK1(2), TNF(1), TNFRSF10B(1), TNFRSF1A(1), TNFRSF1B(2), TNFRSF21(2), TNFSF10(9), TP53(50), TP73(4), TRADD(2), TRAF2(1), TRAF3(1)	67129094	162	125	143	32	10	24	20	50	53	5	0.0299	1.000	1.000
513	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	28	BRAF(6), CPEB1(3), EGFR(10), ERBB2(8), ERBB4(11), ETS1(3), ETS2(1), ETV6(2), FMN2(8), GRB2(3), KRAS(6), MAPK1(1), MAPK3(3), NOTCH1(9), NOTCH2(12), NOTCH3(13), NOTCH4(7), PIWIL1(2), PIWIL2(2), PIWIL3(5), PIWIL4(4), RAF1(5), SOS1(7), SOS2(7), SPIRE1(1), SPIRE2(3)	59823273	142	124	133	31	23	15	20	51	30	3	0.0978	1.000	1.000
514	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP2(1), BMP4(2), BMP5(1), BMP6(1), BMP7(5), BMP8A(5), BMP8B(1), BTRC(4), CSNK1A1(2), CSNK1E(3), CSNK1G2(1), CSNK1G3(1), FBXW11(1), GLI1(8), GLI2(4), GLI3(7), GSK3B(3), HHIP(3), IHH(1), LRP2(29), PRKACA(1), PRKACB(2), PRKACG(3), PRKX(2), PTCH1(10), PTCH2(3), SHH(3), SMO(5), STK36(2), SUFU(3), WNT1(2), WNT10A(3), WNT11(1), WNT2(3), WNT2B(3), WNT3(2), WNT3A(1), WNT5B(2), WNT7A(1), WNT7B(2), WNT8A(2), WNT8B(1), WNT9B(3), ZIC2(2)	69031994	145	121	135	41	19	19	14	52	41	0	0.582	1.000	1.000
515	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(3), ALPL(4), ALPP(4), ALPPL2(5), ASCC3(7), ATP13A2(8), DDX18(4), DDX23(3), DDX4(6), DDX41(2), DDX47(2), DDX50(8), DDX52(2), DDX54(3), DDX55(4), DDX56(2), DHX58(3), ENTPD7(3), EP400(14), ERCC2(1), ERCC3(3), FPGS(4), GGH(3), IFIH1(2), MOV10L1(8), NUDT5(4), PTS(1), QDPR(1), RAD54B(1), RAD54L(2), RUVBL2(2), SETX(12), SKIV2L2(2), SMARCA2(6), SMARCA5(3)	73666171	142	120	138	45	10	26	24	44	37	1	0.539	1.000	1.000
516	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	52	ADORA3(2), ALG6(3), CCKBR(3), CCR2(2), CCR3(1), CCR5(1), CELSR1(16), CELSR2(10), CELSR3(11), CHRM2(5), CHRM3(3), CIDEB(2), EMR2(3), EMR3(9), F2R(2), FSHR(2), GPR116(6), GPR133(7), GPR143(1), GPR17(2), GPR18(2), GPR56(1), GPR61(1), GPR84(3), GRM1(5), GRPR(2), HRH4(1), LGR6(2), LPHN2(4), LPHN3(11), LTB4R2(2), NTSR1(2), OR2M4(1), P2RY11(1), P2RY13(1), PTGFR(5), SMO(5), SSTR2(2), TSHR(3), VN1R1(1)	76067456	146	114	141	41	19	17	23	52	35	0	0.348	1.000	1.000
517	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	94	ANK2(20), B3GALT4(2), CDR1(2), DGKI(1), IL6ST(5), PIGK(2), RPL10(1), RPL11(3), RPL13(1), RPL18(2), RPL18A(3), RPL19(1), RPL21(1), RPL22(3), RPL23(1), RPL24(1), RPL26(1), RPL27(1), RPL28(2), RPL3(2), RPL30(3), RPL31(1), RPL32(1), RPL34(1), RPL35(1), RPL38(1), RPL3L(3), RPL4(2), RPL5(3), RPL6(1), RPL7(1), RPL7A(1), RPL8(1), RPLP0(1), RPS11(1), RPS13(1), RPS14(2), RPS16(1), RPS19(1), RPS2(2), RPS20(1), RPS21(2), RPS24(1), RPS26(1), RPS27(1), RPS27A(1), RPS29(1), RPS3(2), RPS3A(1), RPS4Y1(1), RPS6KA1(7), RPS6KA3(2), RPS6KA6(1), RPS6KB1(2), RPS6KB2(3), RPS8(1), RPS9(1), RPSA(1), SLC36A2(2), TBC1D10C(2), TSPAN9(1), UBA52(1), UBB(1), UBC(6)	61074475	127	114	123	32	8	11	19	51	36	2	0.527	1.000	1.000
518	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	B2M(3), CALR(2), CANX(3), CD4(10), CD74(1), CD8A(1), CIITA(5), CREB1(1), CTSB(4), CTSS(1), HLA-A(6), HLA-B(9), HLA-C(13), HLA-DOB(1), HLA-DPA1(1), HLA-DPB1(3), HLA-DQA1(3), HLA-DQA2(3), HLA-DQB1(3), HLA-DRA(1), HLA-DRB1(6), HLA-DRB5(8), HLA-E(2), HLA-F(1), HSP90AA1(6), HSP90AB1(7), HSPA5(2), IFI30(2), IFNA1(1), IFNA14(1), IFNA16(1), IFNA2(2), IFNA21(3), IFNA5(1), IFNA7(3), IFNA8(2), KIR2DL3(1), KIR3DL1(3), KIR3DL3(3), KLRC1(2), KLRC2(3), KLRC3(2), LTA(1), NFYA(3), NFYC(3), PSME2(2), RFX5(4), RFXAP(1), TAP2(1)	51793597	151	113	142	38	6	22	19	63	39	2	0.565	1.000	1.000
519	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT1(1), AKT2(4), AKT3(2), ASAH1(2), BRAF(6), DAG1(3), DRD2(2), EGFR(10), EPHB2(3), GRB2(3), ITPKA(1), ITPKB(3), ITPR1(11), ITPR2(14), ITPR3(7), KCNJ3(4), MAPK1(1), PI3(1), PIK3CB(6), PITX2(2), PLCB1(3), PLCB2(5), PLCB3(4), PLCB4(5), RAF1(5), RGS20(1), SHC1(4), SOS1(7), SOS2(7), SRC(2), STAT3(4), TERF2IP(1)	68747148	134	113	131	33	14	21	24	42	32	1	0.116	1.000	1.000
520	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	ACTG1(3), APAF1(4), ARHGDIB(1), BAG4(1), BID(2), BIRC2(3), BIRC3(6), CASP2(1), CASP6(1), CASP7(1), CASP8(1), CASP9(2), CFLAR(3), CHUK(2), DAXX(6), DFFA(1), DFFB(1), GSN(4), LMNA(2), LMNB1(4), LMNB2(2), MAP2K7(3), MAP3K1(8), MAP3K5(5), NFKB1(1), NFKBIA(1), NUMA1(5), PAK2(4), PRKCD(5), PRKDC(10), PSEN1(1), PSEN2(2), PTK2(3), RASA1(7), RB1(4), RELA(7), RIPK1(2), SPTAN1(11), TNF(1), TNFRSF1A(1), TNFRSF1B(2), TRADD(2), TRAF2(1)	81693533	137	110	134	40	4	21	22	44	43	3	0.580	1.000	1.000
521	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	42	AKT1(1), ASAH1(2), ATF1(2), BRAF(6), CREB1(1), CREB5(3), CREBBP(13), DAG1(3), EGR1(10), EGR2(1), EGR3(2), EGR4(2), ELK1(2), FRS2(3), JUN(2), MAP1B(12), MAP2K7(3), MAPK1(1), MAPK10(2), MAPK3(3), MAPK8IP1(4), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2), NTRK1(6), PIK3C2G(5), PIK3CA(16), PIK3CD(2), PIK3R1(5), PTPN11(1), RPS6KA3(2), SHC1(4), SRC(2), TERF2IP(1), TH(4)	60111551	130	110	114	31	15	29	13	41	31	1	0.0934	1.000	1.000
522	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(11), AXIN1(5), CCND2(1), CCND3(1), CSNK1E(3), CTNNB1(4), DVL1(1), DVL2(1), DVL3(1), FBXW2(1), FZD1(2), FZD10(3), FZD2(3), FZD3(1), FZD5(3), FZD7(3), FZD8(2), GSK3B(3), JUN(2), LDLR(4), MAPK10(2), MAPK9(2), MYC(1), PAFAH1B1(2), PPP2R5C(3), PPP2R5E(3), PRKCA(3), PRKCD(5), PRKCE(4), PRKCG(5), PRKCH(4), PRKCI(5), PRKCQ(4), PRKCZ(1), PRKD1(3), SFRP4(2), WNT1(2), WNT10A(3), WNT11(1), WNT2(3), WNT2B(3), WNT3(2), WNT5B(2), WNT7A(1), WNT7B(2)	67682022	123	109	120	31	16	18	10	41	38	0	0.246	1.000	1.000
523	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	70	ADH1A(2), ADH1B(2), ADH4(1), ADH5(1), ADH6(3), ADHFE1(3), AKR1C1(2), AKR1C2(1), AKR1C3(2), AKR1C4(1), ALDH1A3(4), ALDH3B1(3), ALDH3B2(2), CYP1A1(1), CYP1A2(6), CYP1B1(2), CYP2B6(1), CYP2C18(3), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP2E1(1), CYP2F1(4), CYP3A43(2), CYP3A5(1), CYP3A7(2), DHDH(4), EPHX1(5), GSTA1(2), GSTA2(1), GSTA3(1), GSTA4(1), GSTA5(1), GSTK1(2), GSTM1(2), GSTM2(1), GSTM4(1), GSTM5(1), GSTT1(1), UGT1A1(5), UGT1A10(1), UGT1A3(2), UGT1A4(3), UGT1A5(4), UGT1A6(5), UGT1A7(4), UGT1A9(6), UGT2A1(5), UGT2A3(2), UGT2B11(2), UGT2B15(1), UGT2B28(4), UGT2B4(4), UGT2B7(6)	67975913	130	107	126	33	12	11	22	50	34	1	0.413	1.000	1.000
524	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	ANKHD1(12), EEF1A2(4), EEF1B2(3), EEF1D(1), EEF1G(3), EEF2(2), EEF2K(2), EIF1AX(1), EIF2AK1(4), EIF2AK2(4), EIF2AK3(3), EIF2B1(1), EIF2B2(1), EIF2B3(1), EIF2B4(1), EIF2B5(3), EIF2S2(2), EIF2S3(2), EIF4A1(1), EIF4A2(6), EIF4E(2), EIF4G1(9), EIF4G3(7), EIF5(4), EIF5A(2), EIF5B(1), ETF1(2), GSPT2(1), PABPC1(17), PABPC3(17), PAIP1(4), SLC35A4(3)	51821999	126	106	120	37	16	23	18	38	28	3	0.471	1.000	1.000
525	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(2), ADH1B(2), ADH4(1), ADH5(1), ADH6(3), ADHFE1(3), AGK(7), AGPAT1(1), AGPAT2(1), AKR1A1(1), AKR1B1(3), ALDH1A3(4), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ALDH7A1(1), CEL(2), DAK(3), DGAT2(1), DGKA(4), DGKB(2), DGKD(4), DGKE(5), DGKG(6), DGKH(6), DGKI(1), DGKQ(3), DGKZ(3), GK(2), GK2(3), GLA(1), GLB1(5), GPAM(5), LCT(5), LIPA(1), LIPC(1), LIPF(1), LPL(6), PNLIP(4), PNPLA3(3), PPAP2B(2), PPAP2C(3)	69487128	122	105	119	31	14	16	15	40	37	0	0.234	1.000	1.000
526	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(3), ACSS2(8), ADH1A(2), ADH1B(2), ADH4(1), ADH5(1), ADH6(3), ADHFE1(3), AKR1A1(1), ALDH1A3(4), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ALDH3B1(3), ALDH3B2(2), ALDH7A1(1), ALDOA(2), ALDOB(5), DLAT(3), DLD(4), ENO1(6), ENO2(2), ENO3(2), G6PC(3), GALM(2), GAPDH(3), GAPDHS(4), GCK(1), GPI(3), HK1(7), LDHAL6B(1), LDHB(1), LDHC(3), PDHA1(1), PDHA2(3), PDHB(1), PFKL(3), PFKM(3), PFKP(3), PGAM2(2), PGAM4(1), PGK1(3), PGK2(1), PGM1(1), PKLR(1), TPI1(1)	68192556	120	101	110	30	12	10	16	33	47	2	0.513	1.000	1.000
527	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	CALM2(1), ELK1(2), FCER1A(1), FOS(1), GRB2(3), HRAS(1), JUN(2), LYN(3), MAP2K7(3), MAP3K1(8), MAPK1(1), MAPK3(3), NFATC1(4), NFATC2(6), NFATC3(8), NFATC4(3), PAK2(4), PIK3CA(16), PIK3R1(5), PLA2G4A(2), PLCG1(3), PPP3CA(2), PPP3CB(1), PPP3CC(3), RAF1(5), SHC1(4), SOS1(7), SYK(2), SYT1(1), VAV1(6)	49920775	111	96	102	30	13	20	11	38	29	0	0.428	1.000	1.000
528	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	44	AGL(7), AMY1A(2), AMY1B(4), AMY1C(2), AMY2A(1), AMY2B(2), ENPP1(2), ENPP3(2), G6PC(3), GAA(4), GBE1(1), GCK(1), GPI(3), GUSB(5), GYS1(3), GYS2(2), HK1(7), MGAM(8), PGM1(1), PYGB(3), PYGL(1), PYGM(4), RNPC3(1), SI(9), UCHL1(1), UCHL3(1), UGDH(1), UGT1A1(5), UGT1A10(1), UGT1A3(2), UGT1A4(3), UGT1A5(4), UGT1A6(5), UGT1A7(4), UGT1A9(6), UGT2B15(1), UGT2B4(4), UXS1(1)	73684147	117	96	114	34	10	11	19	38	39	0	0.747	1.000	1.000
529	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	ACAT1(1), ACMSD(2), ALDH1A1(1), ALDH1A2(1), ALDH1A3(4), ALDH1B1(3), ALDH2(4), ALDH3A2(3), AOC2(5), AOC3(1), AOX1(8), CAT(3), CYP19A1(2), CYP1A1(1), CYP1A2(6), CYP2A13(6), CYP2A6(1), CYP2A7(2), CYP2B6(1), CYP2C18(3), CYP2C19(1), CYP2C8(1), CYP2C9(1), CYP2D6(4), CYP2E1(1), CYP2F1(4), CYP2J2(4), CYP3A5(1), CYP3A7(2), CYP4B1(3), CYP51A1(2), DDC(3), ECHS1(3), EHHADH(6), GCDH(5), HAAO(2), HADHA(4), KYNU(3), MAOA(2), MAOB(3), TDO2(1), TPH1(3), WARS(1), WARS2(1)	64531470	119	95	114	30	18	13	16	45	26	1	0.257	1.000	1.000
530	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAS1(5), ALAS2(3), BLVRA(1), COX10(5), COX15(4), CP(4), CPOX(5), EPRS(3), FECH(2), FTH1(1), FTMT(5), GUSB(5), HCCS(1), HMOX1(3), HMOX2(1), MMAB(1), PPOX(3), UGT1A1(5), UGT1A10(1), UGT1A3(2), UGT1A4(3), UGT1A5(4), UGT1A6(5), UGT1A7(4), UGT1A9(6), UGT2A1(5), UGT2A3(2), UGT2B11(2), UGT2B15(1), UGT2B28(4), UGT2B4(4), UGT2B7(6), UROD(1)	49076782	107	94	101	32	9	9	20	41	28	0	0.765	1.000	1.000
531	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	43	CEBPA(2), CHUK(2), DAXX(6), EGF(5), EGFR(10), ETS1(3), ETS2(1), FOS(1), HOXA7(2), HRAS(1), IKBKB(3), JUN(2), MAP2K3(3), MAP2K7(3), MAP3K1(8), MAP3K5(5), MAPK1(1), MAPK13(1), MAPK14(2), MAPK3(3), NFKB1(1), NFKBIA(1), PPP2CA(1), PRKCA(3), PRKCD(5), PRKCE(4), PRKCG(5), PRKCH(4), PRKCQ(4), RAF1(5), RELA(7), RIPK1(2), SP1(2), TNF(1), TNFRSF1A(1), TNFRSF1B(2), TRAF2(1)	57163113	113	94	107	30	13	8	7	43	41	1	0.735	1.000	1.000
532	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	ACHE(1), AGPAT1(1), AGPAT2(1), CDS2(1), CHAT(5), CHKB(2), CHPT1(2), DGKA(4), DGKB(2), DGKD(4), DGKE(5), DGKG(6), DGKH(6), DGKI(1), DGKQ(3), DGKZ(3), ESCO1(4), ESCO2(1), ETNK1(3), ETNK2(2), GPAM(5), GPD1(2), GPD1L(3), GPD2(2), LCAT(5), LYPLA1(1), PCYT1A(2), PISD(1), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(5), PLD1(3), PLD2(5), PNPLA3(3), PPAP2B(2), PPAP2C(3), PTDSS1(2), PTDSS2(1), SH3GLB1(3)	77494873	110	92	106	28	15	16	12	31	36	0	0.260	1.000	1.000
533	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(6), ACTB(4), ACTG1(3), ARHGEF2(3), ARPC5L(1), CDC42(1), CDH1(3), CTNNB1(4), EZR(2), FYN(2), HCLS1(1), ITGB1(6), LY96(1), NCK1(1), NCK2(1), NCL(7), OCLN(3), PRKCA(3), ROCK1(7), ROCK2(3), TLR4(2), TLR5(5), TUBA1A(2), TUBA3C(1), TUBA3D(3), TUBA4A(5), TUBA8(1), TUBAL3(4), TUBB(3), TUBB1(3), TUBB2B(2), TUBB8(4), WAS(1), WASL(9)	60476650	107	92	106	45	10	21	20	32	24	0	0.963	1.000	1.000
534	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(6), ACTB(4), ACTG1(3), ARHGEF2(3), ARPC5L(1), CDC42(1), CDH1(3), CTNNB1(4), EZR(2), FYN(2), HCLS1(1), ITGB1(6), LY96(1), NCK1(1), NCK2(1), NCL(7), OCLN(3), PRKCA(3), ROCK1(7), ROCK2(3), TLR4(2), TLR5(5), TUBA1A(2), TUBA3C(1), TUBA3D(3), TUBA4A(5), TUBA8(1), TUBAL3(4), TUBB(3), TUBB1(3), TUBB2B(2), TUBB8(4), WAS(1), WASL(9)	60476650	107	92	106	45	10	21	20	32	24	0	0.963	1.000	1.000
535	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(8), AR(18), ESR2(5), HNF4A(3), NPM1(2), NR1D2(2), NR1H3(2), NR1I2(1), NR1I3(1), NR2C2(1), NR2E1(2), NR2F1(2), NR2F2(7), NR2F6(1), NR3C1(4), NR4A1(1), NR4A2(1), NR5A1(1), NR5A2(2), PGR(4), PPARD(1), PPARG(3), RARA(4), RARB(2), RARG(1), ROR1(1), RORA(4), RORC(2), RXRA(2), RXRB(5), RXRG(2), THRA(2), VDR(2)	48283073	99	91	91	29	11	15	18	40	15	0	0.458	1.000	1.000
536	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	ACTR2(2), ACTR3(1), AKT1(1), DAG1(3), DGKA(4), GCA(3), ITGA9(3), ITPKA(1), ITPKB(3), ITPR1(11), ITPR2(14), ITPR3(7), MAPK1(1), MAPK3(3), NR1I3(1), PAK1(4), PDE3A(5), PDE3B(3), PI3(1), PIK3C2G(5), PIK3CA(16), PIK3CD(2), PIK3R1(5), RIPK3(1)	57683634	100	91	94	27	11	21	12	37	19	0	0.219	1.000	1.000
537	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(1), ARSD(1), ARSE(4), CYP11B1(4), CYP11B2(2), CYP19A1(2), HSD11B1(1), HSD11B2(1), HSD17B1(2), HSD17B2(1), HSD17B8(2), HSD3B1(1), LCMT1(1), LCMT2(4), METTL2B(1), PRMT2(1), PRMT3(2), PRMT5(5), PRMT6(2), PRMT7(3), PRMT8(3), SRD5A1(1), SULT2A1(1), UGT1A1(5), UGT1A10(1), UGT1A3(2), UGT1A4(3), UGT1A5(4), UGT1A6(5), UGT1A7(4), UGT1A9(6), UGT2A1(5), UGT2A3(2), UGT2B11(2), UGT2B15(1), UGT2B28(4), UGT2B4(4), UGT2B7(6)	57945032	100	90	100	25	6	8	22	32	32	0	0.378	1.000	1.000
538	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(4), AARS2(5), CARS(6), CARS2(3), DARS(4), DARS2(1), EPRS(3), FARSA(3), HARS(1), HARS2(1), IARS(4), IARS2(6), KARS(1), LARS(7), LARS2(2), MARS(3), MARS2(3), MTFMT(1), NARS2(6), PARS2(4), QARS(4), RARS(4), RARS2(2), SARS(2), TARS(6), TARS2(5), VARS(3), VARS2(6), WARS(1), WARS2(1), YARS(1), YARS2(1)	62976054	104	85	100	29	3	15	14	44	28	0	0.659	1.000	1.000
539	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	A4GALT(1), B3GALNT1(2), B3GALT1(1), B3GALT2(2), B3GALT4(2), B3GALT5(3), B3GNT1(2), B3GNT2(4), B3GNT3(1), B3GNT5(1), B4GALNT1(1), B4GALT1(2), B4GALT2(1), B4GALT3(2), B4GALT4(2), B4GALT6(1), FUT2(1), FUT3(2), FUT4(3), FUT5(1), FUT6(4), GBGT1(3), GCNT2(5), PIGB(1), PIGC(1), PIGG(1), PIGK(2), PIGL(2), PIGM(3), PIGN(2), PIGO(5), PIGP(1), PIGQ(3), PIGS(1), PIGT(6), PIGU(2), PIGV(1), PIGZ(3), ST3GAL1(2), ST3GAL3(3), ST3GAL4(2), ST3GAL5(1), ST6GALNAC3(3), ST6GALNAC4(1), ST6GALNAC5(5), ST6GALNAC6(1), ST8SIA1(2), ST8SIA5(3)	56439467	104	85	98	29	11	17	10	32	33	1	0.569	1.000	1.000
540	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	AGMAT(2), ALDH1A1(1), ALDH1A2(1), ALDH1A3(4), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ALDH4A1(2), AMD1(2), AOC2(5), AOC3(1), ARG1(2), ARG2(1), ASL(4), CKB(1), CKMT1B(1), CPS1(5), DAO(1), GATM(2), GLUD1(1), GOT1(3), GOT2(3), MAOA(2), MAOB(3), NOS1(10), NOS3(3), OAT(3), ODC1(3), OTC(1), P4HA1(4), P4HA2(1), P4HA3(2), P4HB(2), PYCR1(1), RARS(4), SMS(2)	52166213	93	84	91	23	9	6	17	28	33	0	0.446	1.000	1.000
541	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOA(2), ALDOB(5), DLAT(3), DLD(4), ENO1(6), ENO2(2), ENO3(2), G6PC(3), GAPDH(3), GAPDHS(4), GCK(1), GOT1(3), GOT2(3), GPI(3), HK1(7), LDHAL6B(1), LDHB(1), LDHC(3), MDH1(1), MDH2(1), PC(8), PCK1(9), PDHA1(1), PDHA2(3), PDHB(1), PDHX(1), PFKL(3), PFKM(3), PFKP(3), PGAM2(2), PGK1(3), PGK2(1), PKLR(1), TNFAIP1(1), TPI1(1)	49444447	99	84	94	28	7	11	14	22	44	1	0.697	1.000	1.000
542	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(3), CDC7(1), CDK2(2), CDT1(2), DIAPH2(3), MCM10(3), MCM2(9), MCM3(2), MCM4(1), MCM5(3), MCM6(6), MCM7(5), NACA(11), PCNA(3), POLD1(8), POLD2(1), POLD3(1), POLE(6), POLE2(1), PRIM1(2), RFC1(4), RFC2(1), RFC4(2), RFC5(2), RPA1(2), RPA2(2), RPA3(1), RPA4(2), RPS27A(1), UBA52(1), UBB(1), UBC(6)	59813784	98	83	89	26	10	13	11	34	30	0	0.439	1.000	1.000
543	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(2), ADH1B(2), ADH4(1), ADH6(3), ADHFE1(3), AGPAT1(1), AGPAT2(1), AKR1A1(1), AKR1B1(3), ALDH1A1(1), ALDH1A2(1), ALDH1A3(4), ALDH1B1(3), ALDH2(4), ALDH3A2(3), CEL(2), DGKA(4), DGKB(2), DGKD(4), DGKE(5), DGKG(6), DGKH(6), DGKQ(3), DGKZ(3), GK(2), GLA(1), GLB1(5), LCT(5), LIPC(1), LIPF(1), LPL(6), PNLIP(4), PPAP2B(2), PPAP2C(3)	57038692	98	83	95	27	14	13	11	30	30	0	0.355	1.000	1.000
544	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	AGXT(2), AGXT2(1), ALAS1(5), ALAS2(3), AMT(1), AOC2(5), AOC3(1), BHMT(5), CBS(1), CHDH(4), CHKB(2), CPT1B(1), CTH(2), DAO(1), DLD(4), DMGDH(4), GATM(2), GLDC(4), MAOA(2), MAOB(3), PISD(1), PLCB2(5), PLCG1(3), PLCG2(3), SARDH(4), SARS(2), SHMT1(4), SHMT2(6), TARS(6)	49604167	87	83	83	22	9	11	16	23	27	1	0.314	1.000	1.000
545	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(1), ACTN1(1), ACTN2(3), BCAR1(5), BCR(2), CAPN1(2), CSK(4), FYN(2), GRB2(3), HRAS(1), ITGA1(8), ITGB1(6), JUN(2), MAP2K2(1), MAPK1(1), MAPK3(3), PPP1R12B(3), PTK2(3), PXN(3), RAF1(5), RAP1A(1), ROCK1(7), SHC1(4), SOS1(7), SRC(2), TLN1(12), VCL(3), ZYX(1)	55077457	96	83	95	28	8	12	7	42	26	1	0.664	1.000	1.000
546	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	AKT1(1), APC(11), ASAH1(2), CAV3(1), DAG1(3), DLG4(1), EPHB2(3), GNAI1(3), ITPR1(11), ITPR2(14), ITPR3(7), KCNJ3(4), MAPK1(1), PITX2(2), RHO(1), RYR1(23)	53654839	88	83	88	24	14	12	13	32	17	0	0.282	1.000	1.000
547	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(8), ACACB(5), ACAT1(1), ACOT12(1), ACSS1(3), ACSS2(8), AKR1B1(3), ALDH1A3(4), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ALDH7A1(1), DLAT(3), DLD(4), GLO1(1), GRHPR(2), HAGH(2), LDHAL6B(1), LDHB(1), LDHC(3), MDH1(1), MDH2(1), ME1(1), ME2(3), ME3(2), PC(8), PCK1(9), PCK2(2), PDHA1(1), PDHA2(3), PDHB(1), PKLR(1)	54814918	94	82	90	25	6	10	17	22	37	2	0.627	1.000	1.000
548	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG1(3), ACTG2(2), ACTR2(2), ACTR3(1), AKT1(1), CDC42(1), CFL1(1), CFL2(1), FLNA(5), FLNC(7), FSCN1(3), FSCN2(1), FSCN3(2), GDI2(2), LIMK1(6), MYH2(9), MYLK(5), MYLK2(1), PAK1(4), PAK2(4), PAK3(2), PAK4(5), PAK6(4), PAK7(3), PFN1(1), RHO(1), ROCK1(7), ROCK2(3), WASF1(1), WASL(9)	55427232	97	82	95	28	9	17	6	30	35	0	0.528	1.000	1.000
549	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	35	AKT1(1), AKT2(4), AKT3(2), ARHGEF11(6), CDC42(1), DLG4(1), GNA13(6), LPA(9), MAP3K1(8), MAP3K5(5), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIB(2), NFKBIL1(2), PDK1(1), PHKA2(5), PI3(1), PIK3CB(6), PLD1(3), PLD2(5), PLD3(4), PTK2(3), RDX(2), ROCK1(7), ROCK2(3), TBXA2R(4)	58459367	96	82	92	33	9	8	11	40	28	0	0.878	1.000	1.000
550	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(2), ADH1B(2), ADH4(1), ADH6(3), ADHFE1(3), AKR1A1(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(4), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ALDH3B1(3), ALDH3B2(2), ALDOA(2), ALDOB(5), DLAT(3), DLD(4), ENO1(6), ENO2(2), ENO3(2), G6PC(3), GAPDH(3), GCK(1), GPI(3), HK1(7), LDHB(1), LDHC(3), PDHA1(1), PDHA2(3), PDHB(1), PFKM(3), PFKP(3), PGK1(3), PGM1(1), PKLR(1), TPI1(1)	57205631	95	81	86	27	9	7	12	28	38	1	0.763	1.000	1.000
551	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(2), ADH1B(2), ADH4(1), ADH6(3), ADHFE1(3), AKR1A1(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(4), ALDH1B1(3), ALDH2(4), ALDH3A2(3), ALDH3B1(3), ALDH3B2(2), ALDOA(2), ALDOB(5), DLAT(3), DLD(4), ENO1(6), ENO2(2), ENO3(2), G6PC(3), GAPDH(3), GCK(1), GPI(3), HK1(7), LDHB(1), LDHC(3), PDHA1(1), PDHA2(3), PDHB(1), PFKM(3), PFKP(3), PGK1(3), PGM1(1), PKLR(1), TPI1(1)	57205631	95	81	86	27	9	7	12	28	38	1	0.763	1.000	1.000
552	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	IMPA1(1), INPP4A(3), INPP4B(3), INPP5A(1), INPPL1(4), ITPKA(1), ITPKB(3), MIOX(2), OCRL(3), PIK3C2A(8), PIK3C2B(5), PIK3C2G(5), PIK3CA(16), PIK3CB(6), PIK3CG(4), PLCB1(3), PLCB2(5), PLCB3(4), PLCB4(5), PLCD1(3), PLCG1(3), PLCG2(3)	53128384	91	81	84	28	6	15	9	33	28	0	0.758	1.000	1.000
553	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	26	BRCA1(8), CREBBP(13), EP300(16), ERCC3(3), GRIP1(5), GTF2A1(3), GTF2E1(1), GTF2F1(2), HDAC1(2), HDAC4(1), HDAC5(3), HDAC6(4), MEF2C(1), NCOR2(7), NRIP1(6), PELP1(1), POLR2A(11), TBP(2)	54844927	89	80	85	47	6	9	16	30	28	0	0.998	1.000	1.000
554	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(1), AGPAT1(1), AGPAT2(1), AGPS(2), CDS2(1), CHAT(5), CHKB(2), CLC(2), CPT1B(1), DGKA(4), DGKB(2), DGKD(4), DGKE(5), DGKG(6), DGKH(6), DGKQ(3), DGKZ(3), ETNK1(3), GPD1(2), GPD2(2), LCAT(5), LYPLA1(1), PAFAH1B1(2), PAFAH2(1), PCYT1A(2), PISD(1), PLA2G4A(2), PLA2G6(5), PLCB2(5), PLCG1(3), PLCG2(3), PPAP2B(2), PPAP2C(3)	59037628	91	79	88	26	16	15	10	22	28	0	0.335	1.000	1.000
555	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CALM2(1), CAMK1(3), CAMK1G(4), ELK1(2), FPR1(2), GNA15(1), GNB1(3), HRAS(1), MAP2K2(1), MAP2K3(3), MAP3K1(8), MAPK1(1), MAPK14(2), MAPK3(3), NCF1(1), NCF2(2), NFATC1(4), NFATC2(6), NFATC3(8), NFATC4(3), NFKB1(1), NFKBIA(1), PAK1(4), PIK3C2G(5), PLCB1(3), PPP3CA(2), PPP3CB(1), PPP3CC(3), RAF1(5), RELA(7), SYT1(1)	45257365	92	78	86	25	10	10	8	30	33	1	0.707	1.000	1.000
556	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR1(2), AGTR2(1), ATP8A1(3), AVPR1A(1), AVPR2(2), BDKRB1(1), BDKRB2(1), BRS3(2), C3AR1(4), CCKAR(4), CCKBR(3), CCR10(1), CCR2(2), CCR3(1), CCR5(1), CCR6(1), CCR7(1), CX3CR1(1), CXCR4(1), CXCR6(3), EDNRB(3), FPR1(2), FSHR(2), GALR1(1), GALT(3), GRPR(2), LHCGR(1), MC1R(2), MC2R(2), MC3R(2), MC4R(1), MC5R(1), NPY1R(2), NPY2R(3), NTSR1(2), OPRD1(3), OPRK1(2), OPRL1(1), OPRM1(4), OXTR(1), SSTR1(3), SSTR2(2), SSTR3(1), SSTR4(1), TAC4(1), TACR1(1), TACR2(1), TACR3(2), TRHR(2), TSHR(3)	59524154	93	78	93	30	15	12	13	39	14	0	0.483	1.000	1.000
557	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	39	ARNTL(4), BTG1(3), CBX3(1), CLOCK(2), CRY1(1), EIF4G2(4), ETV6(2), HERPUD1(2), HSPA8(9), IDI1(1), KLF9(2), MYF6(5), NCKAP1(2), NCOA4(6), NR1D2(2), PER1(8), PER2(6), PPP1R3C(1), PPP2CB(1), PSMA4(2), SF3A3(2), SUMO3(1), TOB1(4), UGP2(1), ZFR(7)	42750817	79	76	78	31	4	9	14	31	20	1	0.951	1.000	1.000
558	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(1), CALM2(1), ELK1(2), FOS(1), GRB2(3), HRAS(1), JUN(2), LYN(3), MAP3K1(8), MAPK14(2), MAPK3(3), NFATC1(4), NFATC2(6), NFATC3(8), NFATC4(3), PLCG1(3), PPP3CA(2), PPP3CB(1), PPP3CC(3), PRKCA(3), RAF1(5), SHC1(4), SOS1(7), SYK(2), SYT1(1), VAV1(6)	44321389	85	75	82	25	9	11	10	29	26	0	0.702	1.000	1.000
559	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(1), F11(2), F12(9), F13B(3), F2(4), F5(11), F7(1), F8(7), F9(3), FGA(4), FGB(3), FGG(6), LPA(9), PLAT(4), PLG(6), SERPINF2(2), VWF(15)	41598065	90	75	86	34	10	7	15	27	29	2	0.883	1.000	1.000
560	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	ARHGDIB(1), CASP10(3), CASP6(1), CASP7(1), CASP8(1), CFLAR(3), DAXX(6), DFFA(1), DFFB(1), FAF1(1), JUN(2), LMNA(2), LMNB1(4), LMNB2(2), MAP3K1(8), MAP3K7(3), PAK1(4), PAK2(4), PRKDC(10), PTPN13(10), RB1(4), RIPK2(2), SPTAN1(11)	49731360	85	72	85	27	5	6	16	28	28	2	0.790	1.000	1.000
561	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(4), AGTR1(2), ATF2(3), CALM2(1), EGFR(10), ELK1(2), GRB2(3), HRAS(1), JUN(2), MAP2K2(1), MAP3K1(8), MAPK1(1), MAPK3(3), MEF2A(2), MEF2C(1), MEF2D(1), PAK1(4), PRKCA(3), PTK2(3), PTK2B(4), RAF1(5), SHC1(4), SOS1(7), SRC(2), SYT1(1)	39915866	78	70	76	22	8	14	9	28	19	0	0.487	1.000	1.000
562	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	37	CCNH(1), ERCC3(3), GTF2A2(1), GTF2B(2), GTF2E1(1), GTF2E2(3), GTF2F2(1), GTF2H1(2), GTF2H2(1), GTF2H4(2), ILK(4), MNAT1(1), POLR1A(10), POLR1B(4), POLR2A(11), POLR2B(6), POLR2C(1), POLR2F(4), POLR2I(1), POLR2K(1), POLR3B(3), POLR3E(1), POLR3H(2), POLR3K(1), TAF12(1), TAF5(2), TAF6(2), TAF7(2), TAF9(1), TBP(2)	41759952	77	70	73	26	3	9	9	25	31	0	0.833	1.000	1.000
563	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(8), ACAT1(1), ADH5(1), AKR1B1(3), ALDH1A1(1), ALDH1A2(1), ALDH1A3(4), ALDH1B1(3), ALDH2(4), ALDH3A2(3), DLAT(3), DLD(4), GLO1(1), GRHPR(2), HAGH(2), LDHB(1), LDHC(3), MDH1(1), MDH2(1), ME1(1), ME2(3), ME3(2), PC(8), PCK1(9), PDHA1(1), PDHA2(3), PDHB(1), PKLR(1)	43310811	76	69	73	20	5	8	13	21	28	1	0.586	1.000	1.000
564	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B3GNT6(3), B4GALT5(3), GALNT1(1), GALNT10(6), GALNT11(3), GALNT13(3), GALNT14(2), GALNT2(2), GALNT4(4), GALNT5(6), GALNT6(6), GALNT7(9), GALNT8(1), GALNT9(1), GALNTL5(2), GCNT1(2), GCNT3(2), GCNT4(2), OGT(6), ST3GAL1(2), ST6GALNAC1(2), WBSCR17(4)	38238278	72	68	69	26	5	7	12	29	19	0	0.892	1.000	1.000
565	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	ATF2(3), CDC42(1), CREB1(1), DAXX(6), ELK1(2), GRB2(3), HRAS(1), HSPB2(3), MAP3K1(8), MAP3K5(5), MAP3K7(3), MAP3K9(4), MAPK14(2), MAPKAPK2(2), MAX(5), MEF2A(2), MEF2C(1), MEF2D(1), MKNK1(2), MYC(1), PLA2G4A(2), RIPK1(2), RPS6KA5(3), SHC1(4), STAT1(6), TGFB2(2), TGFBR1(1), TRADD(2), TRAF2(1)	43430632	79	67	77	21	8	8	7	35	21	0	0.565	1.000	1.000
566	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	ARHGDIB(1), BAG4(1), CASP2(1), CASP8(1), DFFA(1), DFFB(1), JUN(2), LMNA(2), LMNB1(4), LMNB2(2), MADD(9), MAP3K1(8), MAP3K7(3), PAK1(4), PAK2(4), PRKDC(10), RB1(4), RIPK1(2), SPTAN1(11), TNF(1), TNFRSF1A(1), TRADD(2), TRAF2(1)	46308681	76	66	76	25	3	7	15	24	25	2	0.822	1.000	1.000
567	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(3), ACTG2(2), ADCY3(5), ADCY9(8), ARF1(1), ARF3(3), ARF5(1), ARF6(1), ARL4D(1), ATP6V0A1(5), ATP6V0A2(3), ATP6V0A4(3), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(5), ATP6V1C1(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1E2(2), ATP6V1G1(1), ATP6V1H(1), GNAS(5), PDIA4(2), PLCG1(3), PLCG2(3), PRKCA(3), SEC61B(1), TRIM23(3)	43700456	71	65	70	25	2	8	11	28	22	0	0.941	1.000	1.000
568	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	BCAR1(5), CXCR4(1), GNAI1(3), GNB1(3), HRAS(1), MAPK1(1), MAPK3(3), NFKB1(1), PIK3C2G(5), PIK3CA(16), PIK3R1(5), PLCG1(3), PRKCA(3), PTK2(3), PTK2B(4), PXN(3), RAF1(5), RELA(7)	32937718	72	64	62	27	5	16	5	25	19	2	0.931	1.000	1.000
569	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	ADCY1(2), AKT1(1), ASAH1(2), GNAI1(3), GNB1(3), ITGAV(2), ITGB3(4), MAPK1(1), MAPK3(3), PDGFRA(6), PIK3CA(16), PIK3R1(5), PLCB1(3), PRKCA(3), PTK2(3), SMPD1(5), SMPD2(3), SPHK1(1), SRC(2)	32210770	68	64	60	23	10	17	4	21	16	0	0.686	1.000	1.000
570	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(3), AKR1B10(2), B4GALT1(2), B4GALT2(1), G6PC(3), GAA(4), GALK1(1), GALK2(2), GALT(3), GANC(4), GCK(1), GLA(1), GLB1(5), HK1(7), LALBA(1), LCT(5), MGAM(8), PFKL(3), PFKM(3), PFKP(3), PGM1(1), RDH11(4), RDH12(3), RDH13(1), UGP2(1)	44936912	72	63	71	22	7	10	8	24	23	0	0.703	1.000	1.000
571	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(4), BID(2), BIRC2(3), BIRC3(6), CASP10(3), CASP6(1), CASP7(1), CASP8(1), CASP9(2), CFLAR(3), CHUK(2), DFFA(1), DFFB(1), GAS2(3), LMNA(2), NFKB1(1), NFKBIA(1), RELA(7), RIPK1(2), SPTAN1(11), TNFRSF10B(1), TNFSF10(9), TRADD(2), TRAF2(1)	39279854	70	62	64	18	1	8	13	23	24	1	0.482	1.000	1.000
572	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSA(1), ARSD(1), ARSE(4), ASAH1(2), B4GALT6(1), CERK(6), DEGS1(2), DEGS2(1), ENPP7(2), GAL3ST1(4), GALC(2), GBA(2), GLA(1), GLB1(5), LCT(5), NEU1(1), PPAP2B(2), PPAP2C(3), SGMS1(1), SGPP1(3), SMPD1(5), SMPD2(3), SMPD3(2), SMPD4(2), SPHK1(1), SPHK2(2), SPTLC1(3), SPTLC2(1), UGT8(1)	40831951	69	61	64	25	12	13	6	20	18	0	0.711	1.000	1.000
573	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	BLVRA(1), CP(4), CPOX(5), EPRS(3), FECH(2), GUSB(5), HCCS(1), HMOX1(3), HMOX2(1), PPOX(3), UGT1A1(5), UGT1A10(1), UGT1A3(2), UGT1A4(3), UGT1A5(4), UGT1A6(5), UGT1A7(4), UGT1A9(6), UGT2B15(1), UGT2B4(4), UROD(1)	32302340	64	59	60	21	5	5	14	19	21	0	0.848	1.000	1.000
574	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(5), CALM2(1), GRB2(3), HRAS(1), JUN(2), MAP2K2(1), MAP2K3(3), MAP3K1(8), MAPK1(1), MAPK14(2), MAPK3(3), PAK1(4), PLCG1(3), PRKCA(3), PTK2B(4), RAF1(5), SHC1(4), SOS1(7), SRC(2), SYT1(1)	33410221	63	58	62	21	5	10	5	25	17	1	0.909	1.000	1.000
575	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	DLG4(1), EPHB2(3), F2(4), F2RL1(1), F2RL2(2), F2RL3(1), JUN(2), MAP2K5(3), MAPK1(1), MAPK7(1), PLD1(3), PLD2(5), PLD3(4), PTK2(3), RAF1(5), RASAL1(8), SRC(2), TEC(5), VAV1(6)	32263486	60	57	55	18	9	4	6	25	16	0	0.719	1.000	1.000
576	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(1), ATF1(2), CDC42(1), CREB1(1), CREB5(3), DUSP10(1), EEF2K(2), EIF4E(2), ELK1(2), IL1R1(3), MAP2K3(3), MAP3K10(4), MAP3K4(9), MAP3K5(5), MAP3K7(3), MAPK1(1), MAPK11(1), MAPK12(1), MAPK13(1), MAPK14(2), MAPKAPK2(2), MKNK1(2), MKNK2(2), NFKB1(1), NR2C2(1), TRAF6(2)	39499446	58	55	58	15	5	12	4	25	12	0	0.427	1.000	1.000
577	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(3), GTF2A1(3), GTF2B(2), GTF2E1(1), GTF2F1(2), NCOA1(5), NCOA2(13), NCOA3(8), NCOR2(7), POLR2A(11), RARA(4), RXRA(2), TBP(2)	29423543	63	54	56	30	4	8	8	17	26	0	0.979	1.000	1.000
578	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(11), BAIAP2(3), CASP1(2), CASP7(1), CASP8(1), GAPDH(3), INS(1), INSR(4), ITCH(1), MAGI1(5), MAGI2(4), RERE(10), WWP1(7), WWP2(4)	27823305	57	53	47	23	7	2	7	19	19	3	0.997	1.000	1.000
579	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(4), F2R(2), F2RL3(1), GNAI1(3), GNB1(3), HRAS(1), ITGA1(8), ITGB1(6), MAPK1(1), MAPK3(3), PLA2G4A(2), PLCB1(3), PRKCA(3), PTGS1(2), PTK2(3), RAF1(5), SRC(2), SYK(2), TBXAS1(4)	28684455	58	53	57	21	7	8	7	15	20	1	0.833	1.000	1.000
580	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(1), ACTN1(1), ACTN2(3), CAPN1(2), ITGA1(8), ITGB1(6), ITGB3(4), PTK2(3), PXN(3), SPTAN1(11), SRC(2), TLN1(12)	33627479	56	53	55	23	4	7	4	20	21	0	0.963	1.000	1.000
581	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(1), ARSB(1), ARSD(1), ARSE(4), CYP11B1(4), CYP11B2(2), HSD11B1(1), HSD11B2(1), HSD17B2(1), HSD17B8(2), HSD3B1(1), SRD5A1(1), SULT2A1(1), UGT1A1(5), UGT1A10(1), UGT1A3(2), UGT1A4(3), UGT1A5(4), UGT1A6(5), UGT1A7(4), UGT1A9(6), UGT2B15(1), UGT2B4(4)	31910844	56	52	56	17	3	4	12	15	22	0	0.630	1.000	1.000
582	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	32	CHUK(2), ELK1(2), FOS(1), IKBKB(3), IRAK1(3), JUN(2), LY96(1), MAP2K3(3), MAP3K1(8), MAP3K7(3), MAPK14(2), NFKB1(1), NFKBIA(1), RELA(7), TLR10(3), TLR2(3), TLR3(2), TLR4(2), TLR6(2), TLR7(5), TLR9(1), TRAF6(2)	42857531	59	52	55	16	4	10	3	22	19	1	0.641	1.000	1.000
583	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCR3(1), CFL1(1), GNAS(5), GNB1(3), HRAS(1), LIMK1(6), MAPK1(1), MAPK3(3), MYL2(1), NOX1(7), PIK3C2G(5), PLCB1(3), PPP1R12B(3), PRKCA(3), PTK2(3), RAF1(5), ROCK2(3)	29986422	54	51	50	20	4	4	6	20	20	0	0.971	1.000	1.000
584	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(3), ALDOA(2), ALDOB(5), FPGT(1), GCK(1), GMDS(2), GMPPA(2), GMPPB(1), HK1(7), KHK(5), MPI(2), PFKFB3(4), PFKFB4(1), PFKM(3), PFKP(3), PMM1(1), SORD(10), TPI1(1)	28227694	54	50	46	18	6	5	8	11	24	0	0.918	1.000	1.000
585	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(4), CARS(6), DARS(4), EPRS(3), HARS(1), IARS(4), KARS(1), LARS(7), LARS2(2), MARS(3), MARS2(3), QARS(4), RARS(4), SARS(2), TARS(6), WARS(1), WARS2(1), YARS(1)	37940598	57	49	54	16	1	4	10	24	18	0	0.744	1.000	1.000
586	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(3), B4GALT1(2), B4GALT2(1), G6PC(3), GAA(4), GALK1(1), GALK2(2), GALT(3), GCK(1), GLA(1), GLB1(5), HK1(7), LALBA(1), LCT(5), MGAM(8), PFKM(3), PFKP(3), PGM1(1)	37943653	54	48	53	22	4	8	5	15	22	0	0.968	1.000	1.000
587	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(11), CALM2(1), CAPN2(3), EP300(16), HDAC1(2), MEF2D(1), NFATC1(4), NFATC2(6), PPP3CA(2), PPP3CB(1), PPP3CC(3), PRKCA(3), SYT1(1)	28178328	54	47	49	23	7	4	5	16	22	0	0.985	1.000	1.000
588	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(9), APOA1(1), CYP7A1(1), HMGCR(1), LCAT(5), LDLR(4), LIPC(1), LPL(6), LRP1(15), SCARB1(1), SOAT1(5)	31848173	49	47	47	15	5	8	5	16	15	0	0.576	1.000	1.000
589	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOA(2), ALDOB(5), G6PD(2), GPI(3), H6PD(2), PFKL(3), PFKM(3), PFKP(3), PGD(1), PGM1(1), PRPS1(1), PRPS1L1(2), PRPS2(4), RBKS(1), RPE(2), RPIA(3), TALDO1(1), TKT(3), TKTL1(2), TKTL2(4)	28308157	48	46	45	15	5	10	7	11	15	0	0.681	1.000	1.000
590	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	31	ADRA1A(4), ADRA2A(1), ADRB2(2), CHRM1(2), CHRM2(5), CHRM3(3), CHRM5(2), DRD1(1), DRD2(2), DRD3(3), DRD5(3), HRH2(1), HTR1A(3), HTR1B(1), HTR1D(2), HTR1E(3), HTR1F(2), HTR2A(1), HTR2B(2), HTR2C(1), HTR4(2), HTR6(1), HTR7(2)	29179700	49	45	47	23	8	4	3	21	13	0	0.937	1.000	1.000
591	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	28	BAG4(1), BIRC2(3), BIRC3(6), CASP8(1), CFLAR(3), JUN(2), MAP3K3(3), MAP3K7(3), NFKB1(1), NFKB2(3), NFKBIA(1), NFKBIB(2), NFKBIL1(2), NR2C2(1), RALBP1(3), RIPK1(2), TNF(1), TNFAIP3(2), TNFRSF1A(1), TNFRSF1B(2), TRADD(2), TRAF2(1)	31902512	46	44	46	14	4	8	8	19	7	0	0.463	1.000	1.000
592	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(1), ACTN2(3), BCAR1(5), CSK(4), CTNNA1(9), CTNNA2(7), CTNNB1(4), PTK2(3), PXN(3), SRC(2), VCL(3)	22456638	44	42	44	21	5	5	6	18	9	1	0.973	1.000	1.000
593	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1R(8), DDX20(8), E2F1(1), ETS1(3), ETS2(1), FOS(1), HDAC5(3), HRAS(1), JUN(2), NCOR2(7), RBL2(3), SIN3A(4), SIN3B(4)	30929306	46	42	45	16	7	5	3	19	12	0	0.723	1.000	1.000
594	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSA(1), ARSB(1), ARSD(1), ARSE(4), ASAH1(2), GAL3ST1(4), GALC(2), GBA(2), GLA(1), GLB1(5), LCT(5), NEU1(1), PPAP2B(2), PPAP2C(3), SMPD1(5), SMPD2(3), SPTLC1(3), SPTLC2(1)	27802355	46	42	44	20	8	8	4	14	12	0	0.885	1.000	1.000
595	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(1), AP2A1(4), AP2M1(1), ARF1(1), EEA1(7), GRASP(1), GSK3A(1), GSK3B(3), LYN(3), PFKL(3), PFKM(3), PFKP(3), PLCG1(3), PRKCE(4), PRKCZ(1), RAB5A(1), RPS6KB1(2), VAV2(4)	29563551	46	41	43	17	4	6	7	15	14	0	0.865	1.000	1.000
596	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(4), COL4A2(4), COL4A3(7), COL4A4(3), COL4A5(8), COL4A6(6), P4HB(2), SLC23A1(6), SLC23A2(2), SLC2A1(1), SLC2A3(2)	30108246	45	41	45	16	4	16	2	13	10	0	0.784	1.000	1.000
597	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	CALM2(1), CDKN1A(3), MARCKS(1), NFATC1(4), NFATC2(6), NFATC3(8), NFATC4(3), PLCG1(3), PPP3CA(2), PPP3CB(1), PPP3CC(3), PRKCA(3), SP1(2), SP3(3), SYT1(1)	23924009	44	39	41	16	4	5	5	9	20	1	0.940	1.000	1.000
598	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(1), GALNT10(6), GALNT2(2), GALNT4(4), GALNT6(6), GALNT7(9), GALNT8(1), GALNT9(1), GCNT1(2), ST3GAL1(2), ST3GAL4(2), WBSCR17(4)	17269460	40	39	37	21	2	2	6	15	15	0	0.996	1.000	1.000
599	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(2), ALDOB(5), G6PD(2), GPI(3), H6PD(2), PFKM(3), PFKP(3), PGD(1), PGM1(1), PRPS1(1), PRPS1L1(2), PRPS2(4), RBKS(1), RPE(2), RPIA(3), TAL1(3), TALDO1(1), TKT(3)	23519618	42	39	39	14	3	8	7	10	14	0	0.806	1.000	1.000
600	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	25	ATF1(2), CASP2(1), CHUK(2), IKBKB(3), JUN(2), LTA(1), MAP2K3(3), MAP3K1(8), MAP4K2(2), MAPK14(2), NFKB1(1), NFKBIA(1), RELA(7), RIPK1(2), TANK(1), TNF(1), TNFRSF1A(1), TRADD(2), TRAF2(1)	28736215	43	39	40	12	2	5	4	16	15	1	0.809	1.000	1.000
601	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(4), AP2A1(4), AP2M1(1), BIN1(3), CALM2(1), DNM1(2), EPN1(1), EPS15(1), PICALM(3), PPP3CA(2), PPP3CB(1), PPP3CC(3), SYNJ1(5), SYNJ2(6), SYT1(1)	26162782	38	38	38	13	1	6	7	14	10	0	0.734	1.000	1.000
602	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	28	ANXA1(1), ANXA3(3), ANXA4(3), ANXA6(2), CYP11A1(2), EDNRB(3), HPGD(1), HSD11B1(1), HSD11B2(1), PLA2G4A(2), PTGDR(1), PTGDS(1), PTGER2(1), PTGER4(1), PTGFR(5), PTGIR(1), PTGS1(2), PTGS2(5), TBXAS1(4)	24838875	40	38	40	20	4	5	6	15	9	1	0.961	1.000	1.000
603	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	AKT1(1), PIK3CA(16), PIK3R1(5), PLCB1(3), PLCG1(3), PRKCA(3), VAV1(6)	15232773	37	35	30	12	5	12	3	8	9	0	0.565	1.000	1.000
604	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(1), AGPAT2(1), AGPS(2), CHPT1(2), ENPP2(3), ENPP6(1), PAFAH1B1(2), PAFAH1B2(1), PAFAH2(1), PLA2G10(1), PLA2G12A(1), PLA2G2D(1), PLA2G4A(2), PLA2G6(5), PLD1(3), PLD2(5), PPAP2B(2), PPAP2C(3)	27618832	37	34	35	16	8	4	3	14	8	0	0.887	1.000	1.000
605	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(13), EP300(16), MAPK1(1), MAPK3(3), PELP1(1), SRC(2)	17397310	36	33	33	16	3	4	8	8	13	0	0.929	1.000	1.000
606	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(4), CLOCK(2), CRY1(1), CSNK1E(3), NPAS2(1), PER1(8), PER2(6), PER3(7)	19953118	32	32	30	13	4	1	6	12	9	0	0.896	1.000	1.000
607	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	CISH(2), IL6R(2), JAK1(6), JAK2(7), JAK3(4), PIAS3(3), PTPRU(6), SRC(2), STAT3(4)	17886898	36	32	36	11	2	5	5	14	10	0	0.755	1.000	1.000
608	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(6), JAK2(7), JAK3(4), MAPK1(1), MAPK3(3), STAT3(4), TYK2(7)	13832210	32	32	31	11	3	1	8	11	9	0	0.863	1.000	1.000
609	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(8), ACACB(5), FASN(8), MCAT(2), OLAH(2), OXSM(3)	18489296	28	28	28	11	3	4	4	11	6	0	0.762	1.000	1.000
610	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	16	B3GAT1(3), B3GAT2(1), B3GAT3(2), CHST11(1), CHST12(2), CHST13(1), CHST14(1), CHST3(2), CHST7(1), CHSY1(9), DSE(1), XYLT1(4), XYLT2(2)	15319635	30	28	24	11	5	6	1	7	11	0	0.819	1.000	1.000
611	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	DRD1(1), DRD2(2), GRM1(5), PLCB1(3), PPP1R1B(1), PPP2CA(1), PPP3CA(2), PRKACB(2), PRKACG(3), PRKAR1A(3), PRKAR2B(4)	18749854	27	27	27	14	5	1	2	9	10	0	0.925	1.000	1.000
612	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR2(5), ITPKA(1), PDE1A(1), PDE1B(6), PLCB1(3), PLCB2(5), TRH(8)	12958568	29	27	22	13	6	2	1	6	14	0	0.979	1.000	1.000
613	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	GOSR1(1), SNAP23(1), SNAP29(1), STX10(1), STX11(2), STX16(1), STX17(1), STX18(3), STX19(1), STX2(1), STX4(1), STX7(1), STX8(1), TSNARE1(3), VAMP1(2), VAMP2(1), VTI1A(1), VTI1B(1)	19768357	24	24	24	12	2	6	2	9	5	0	0.867	1.000	1.000
614	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(2), GABRA1(3), GABRA2(1), GABRA3(2), GABRA4(1), GABRA5(1), GABRA6(1), GPHN(5), SRC(2), UBQLN1(3)	14487126	21	21	21	10	2	4	5	7	2	1	0.875	1.000	1.000
615	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAS1(5), ALAS2(3), CPO(1), FECH(2), GATA1(4), HBB(3), UROD(1)	9619204	19	19	17	10	1	1	3	10	4	0	0.962	1.000	1.000
616	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAS1(5), ALAS2(3), CPOX(5), FECH(2), PPOX(3), UROD(1)	9096175	19	19	14	10	0	0	3	6	10	0	0.990	1.000	1.000
